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Search of human proteins with 110611914
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110611914 progesterone receptor [Homo sapiens]
(933 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110611914 progesterone receptor [Homo sapiens] 1878 0.0
gi|21322252 androgen receptor isoform 1 [Homo sapiens] 449 e-126
gi|158508572 nuclear receptor subfamily 3, group C, member 2 [Ho... 443 e-124
gi|58535455 androgen receptor isoform 2 [Homo sapiens] 441 e-123
gi|66528611 nuclear receptor subfamily 3, group C, member 1 isof... 430 e-120
gi|66528586 nuclear receptor subfamily 3, group C, member 1 isof... 430 e-120
gi|66528563 nuclear receptor subfamily 3, group C, member 1 isof... 430 e-120
gi|66528530 nuclear receptor subfamily 3, group C, member 1 isof... 430 e-120
gi|4504133 nuclear receptor subfamily 3, group C, member 1 isofo... 430 e-120
gi|66528677 nuclear receptor subfamily 3, group C, member 1 isof... 425 e-119
gi|66528642 nuclear receptor subfamily 3, group C, member 1 isof... 382 e-106
gi|238550159 estrogen-related receptor beta [Homo sapiens] 178 2e-44
gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens] 178 2e-44
gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens] 178 2e-44
gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens] 178 2e-44
gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens] 178 2e-44
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 176 9e-44
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 176 9e-44
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 176 9e-44
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 176 9e-44
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 171 2e-42
gi|94538328 estrogen receptor beta isoform 2 [Homo sapiens] 169 1e-41
gi|94538325 estrogen receptor beta isoform 2 [Homo sapiens] 169 1e-41
gi|10835013 estrogen receptor beta isoform 1 [Homo sapiens] 169 1e-41
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 120 6e-27
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 120 8e-27
gi|11415052 retinoid X receptor, beta [Homo sapiens] 120 8e-27
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 118 2e-26
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 115 2e-25
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof... 111 3e-24
>gi|110611914 progesterone receptor [Homo sapiens]
Length = 933
Score = 1878 bits (4866), Expect = 0.0
Identities = 933/933 (100%), Positives = 933/933 (100%)
Query: 1 MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF 60
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
Sbjct: 1 MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF 60
Query: 61 PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA 120
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
Sbjct: 61 PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA 120
Query: 121 PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA 180
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
Sbjct: 121 PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA 180
Query: 181 AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK 240
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
Sbjct: 181 AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK 240
Query: 241 PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV 300
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
Sbjct: 241 PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV 300
Query: 301 MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD 360
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
Sbjct: 301 MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD 360
Query: 361 CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG 420
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
Sbjct: 361 CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG 420
Query: 421 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC 480
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
Sbjct: 421 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC 480
Query: 481 KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP 540
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
Sbjct: 481 KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP 540
Query: 541 YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN 600
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
Sbjct: 541 YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN 600
Query: 601 YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV 660
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
Sbjct: 601 YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV 660
Query: 661 GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ 720
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
Sbjct: 661 GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ 720
Query: 721 LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP 780
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
Sbjct: 721 LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP 780
Query: 781 DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ 840
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
Sbjct: 781 DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ 840
Query: 841 FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA 900
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
Sbjct: 841 FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA 900
Query: 901 LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
Sbjct: 901 LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
>gi|21322252 androgen receptor isoform 1 [Homo sapiens]
Length = 920
Score = 449 bits (1155), Expect = e-126
Identities = 335/951 (35%), Positives = 458/951 (48%), Gaps = 146/951 (15%)
Query: 49 SAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDS 108
SA P LL + Q Q ++ Q QQ E + + + +G GS + +
Sbjct: 46 SAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPT 105
Query: 109 GLLDSVLDTLLAPSGPGQSQ---------PSPPACEVTSSWCLFGPELP----EDPPAAP 155
G L VLD PS P + P P A S +LP ED AAP
Sbjct: 106 GYL--VLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKG--LPQQLPAPPDEDDSAAP 161
Query: 156 ATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQ 215
+T +L P G SS +A +L + QLL Q
Sbjct: 162 STLSLLGPTFP------GLSSCSADLKDILSE--ASTMQLL---------------QQQQ 198
Query: 216 AAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRF 275
AV G E S P K LGG + A A + + L
Sbjct: 199 QEAVSEGSSSGRAREASGAPT-SSKDNYLGGTSTISDNAKELCKAVSVSMGLG------- 250
Query: 276 SAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDES--YDGGA 333
VE ++PG D ++ P+L + A+ L E + D A
Sbjct: 251 -------VEALEHLSPGEQLRG----DCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSA 299
Query: 334 GAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEG 393
G ++ S T G+ C+ A P L + +
Sbjct: 300 GKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLE------LPSTLSLYKSGAL 353
Query: 394 AEASARSPRSYLVAGANPAAFPDFPL---GPPPPLPP---------------------RA 429
EA+A R Y +FPL GPPPP PP A
Sbjct: 354 DEAAAYQSRDYY----------NFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAA 403
Query: 430 TPSRPGEAAV-----TAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPG 484
R G+ A A P S S S+A+SS L+ AE +G P C G
Sbjct: 404 AQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHT---LFTAE-----EGQLYGP-CGGGG 454
Query: 485 ASGCLLPRDGLPSTSASAAAAGA-APALY--PALGLNG------LPQLGYQAAVLKEGLP 535
G G AGA AP Y P GL G P + Y ++ +P
Sbjct: 455 GGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSR-VP 513
Query: 536 QVYP--------PYLNY-------LRPDSEASQSPQYSFESLPQKICLICGDEASGCHYG 580
P P+++ +R ++ + PQK CLICGDEASGCHYG
Sbjct: 514 YPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYG 573
Query: 581 VLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFK 640
LTCGSCKVFFKRA EG+ YLCA RNDC +DK RRKNCP+CRLRKC +AGM LG RK K
Sbjct: 574 ALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLK 633
Query: 641 KFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIY 700
K +++ +A + P ++ +Q+ T S + + P +N+L +IEP V+
Sbjct: 634 KLGNLKLQEEGEASSTTSP------TEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVC 687
Query: 701 AGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMV 760
AGHDN +PD+ ++LL+SLN+LGERQL+ VVKW+K+LPGFRNLH+DDQ+ +IQYSWM LMV
Sbjct: 688 AGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMV 747
Query: 761 FGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLC 820
F +GWRS+ +V+ +MLYFAPDL+ NE RM +S YS C+ M + QEF LQ++ +EFLC
Sbjct: 748 FAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLC 807
Query: 821 MKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNL 880
MK LLL + IP++GL++Q F+E+R +YI+EL + I ++K S S+RFYQLTKLLD++
Sbjct: 808 MKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSV 867
Query: 881 HDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFH 931
+ ++LH + + I+S +SV+FPEMM+E+I+ Q+PKIL+G VKP+ FH
Sbjct: 868 QPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH 918
>gi|158508572 nuclear receptor subfamily 3, group C, member 2 [Homo
sapiens]
Length = 984
Score = 443 bits (1139), Expect = e-124
Identities = 223/411 (54%), Positives = 289/411 (70%), Gaps = 18/411 (4%)
Query: 540 PYLNYLRPDSEASQSPQYSF-ESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQ 598
P L Y+ + +S S S P KICL+CGDEASGCHYGV+TCGSCKVFFKRA+EGQ
Sbjct: 575 PVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQ 634
Query: 599 HNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQ 658
HNYLCAGRNDCI+DKIRRKNCPACRL+KC QAGM LG RK KK K++ + + Q
Sbjct: 635 HNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHE-EQPQQQQ 693
Query: 659 PVGVPNESQALSQRFTF-----SPGQDIQLIPPL-----------INLLMSIEPDVIYAG 702
P P Q+ + T+ P + L+P L + +L +IEP+++YAG
Sbjct: 694 PPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAG 753
Query: 703 HDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFG 762
+D++KPDT+ +LL++LN+L +Q++ VVKW+K LPGF+NL ++DQITLIQYSWM L F
Sbjct: 754 YDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFA 813
Query: 763 LGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMK 822
L WRSYKH + Q LYFAPDL+ NE++M +S+ Y LC M QI +FV+LQ++ EE+ MK
Sbjct: 814 LSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMK 873
Query: 823 VLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHD 882
VLLLL+TIP +GL+SQ FEEMR++YI+EL K + S QRFYQLTKLLD++HD
Sbjct: 874 VLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHD 933
Query: 883 LVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
LV L +C TF +S AL VEFP M+ E+I+ QLPK+ +G KPL FH+K
Sbjct: 934 LVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK 984
>gi|58535455 androgen receptor isoform 2 [Homo sapiens]
Length = 388
Score = 441 bits (1133), Expect = e-123
Identities = 205/369 (55%), Positives = 277/369 (75%), Gaps = 6/369 (1%)
Query: 563 PQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPAC 622
PQK CLICGDEASGCHYG LTCGSCKVFFKRA EG+ YLCA RNDC +DK RRKNCP+C
Sbjct: 24 PQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSC 83
Query: 623 RLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQ 682
RLRKC +AGM LG RK KK +++ +A + P ++ +Q+ T S + +
Sbjct: 84 RLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSP------TEETTQKLTVSHIEGYE 137
Query: 683 LIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNL 742
P +N+L +IEP V+ AGHDN +PD+ ++LL+SLN+LGERQL+ VVKW+K+LPGFRNL
Sbjct: 138 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNL 197
Query: 743 HIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMW 802
H+DDQ+ +IQYSWM LMVF +GWRS+ +V+ +MLYFAPDL+ NE RM +S YS C+ M
Sbjct: 198 HVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMR 257
Query: 803 QIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKG 862
+ QEF LQ++ +EFLCMK LLL + IP++GL++Q F+E+R +YI+EL + I ++K
Sbjct: 258 HLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKN 317
Query: 863 VVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILA 922
S S+RFYQLTKLLD++ + ++LH + + I+S +SV+FPEMM+E+I+ Q+PKIL+
Sbjct: 318 PTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILS 377
Query: 923 GMVKPLLFH 931
G VKP+ FH
Sbjct: 378 GKVKPIYFH 386
>gi|66528611 nuclear receptor subfamily 3, group C, member 1 isoform
alpha [Homo sapiens]
Length = 777
Score = 430 bits (1105), Expect = e-120
Identities = 214/390 (54%), Positives = 278/390 (71%), Gaps = 11/390 (2%)
Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
+RPD S S + P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457
Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
AGRNDCI+DKIRRKNCPACR RKC QAGM L RK KK K++ ++ GV
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508
Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
E+ T P QL P L++LL IEP+V+YAG+D++ PD++ ++T+LN LG
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568
Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+ S +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628
Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
+NEQRM Y C M + E +LQVS EE+LCMK LLLL+++P +GL+SQ F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688
Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV 903
+R +YI+EL KAI R+ + QRFYQLTKLLD++H++V+ L YC TF+ + +S+
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMSI 747
Query: 904 EFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
EFPEM++E+I Q+PK G +K LLFH+K
Sbjct: 748 EFPEMLAEIITNQIPKYSNGNIKKLLFHQK 777
>gi|66528586 nuclear receptor subfamily 3, group C, member 1 isoform
alpha [Homo sapiens]
Length = 777
Score = 430 bits (1105), Expect = e-120
Identities = 214/390 (54%), Positives = 278/390 (71%), Gaps = 11/390 (2%)
Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
+RPD S S + P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457
Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
AGRNDCI+DKIRRKNCPACR RKC QAGM L RK KK K++ ++ GV
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508
Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
E+ T P QL P L++LL IEP+V+YAG+D++ PD++ ++T+LN LG
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568
Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+ S +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628
Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
+NEQRM Y C M + E +LQVS EE+LCMK LLLL+++P +GL+SQ F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688
Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV 903
+R +YI+EL KAI R+ + QRFYQLTKLLD++H++V+ L YC TF+ + +S+
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMSI 747
Query: 904 EFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
EFPEM++E+I Q+PK G +K LLFH+K
Sbjct: 748 EFPEMLAEIITNQIPKYSNGNIKKLLFHQK 777
>gi|66528563 nuclear receptor subfamily 3, group C, member 1 isoform
alpha [Homo sapiens]
Length = 777
Score = 430 bits (1105), Expect = e-120
Identities = 214/390 (54%), Positives = 278/390 (71%), Gaps = 11/390 (2%)
Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
+RPD S S + P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457
Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
AGRNDCI+DKIRRKNCPACR RKC QAGM L RK KK K++ ++ GV
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508
Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
E+ T P QL P L++LL IEP+V+YAG+D++ PD++ ++T+LN LG
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568
Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+ S +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628
Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
+NEQRM Y C M + E +LQVS EE+LCMK LLLL+++P +GL+SQ F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688
Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV 903
+R +YI+EL KAI R+ + QRFYQLTKLLD++H++V+ L YC TF+ + +S+
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMSI 747
Query: 904 EFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
EFPEM++E+I Q+PK G +K LLFH+K
Sbjct: 748 EFPEMLAEIITNQIPKYSNGNIKKLLFHQK 777
>gi|66528530 nuclear receptor subfamily 3, group C, member 1 isoform
alpha [Homo sapiens]
Length = 777
Score = 430 bits (1105), Expect = e-120
Identities = 214/390 (54%), Positives = 278/390 (71%), Gaps = 11/390 (2%)
Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
+RPD S S + P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457
Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
AGRNDCI+DKIRRKNCPACR RKC QAGM L RK KK K++ ++ GV
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508
Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
E+ T P QL P L++LL IEP+V+YAG+D++ PD++ ++T+LN LG
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568
Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+ S +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628
Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
+NEQRM Y C M + E +LQVS EE+LCMK LLLL+++P +GL+SQ F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688
Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV 903
+R +YI+EL KAI R+ + QRFYQLTKLLD++H++V+ L YC TF+ + +S+
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMSI 747
Query: 904 EFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
EFPEM++E+I Q+PK G +K LLFH+K
Sbjct: 748 EFPEMLAEIITNQIPKYSNGNIKKLLFHQK 777
>gi|4504133 nuclear receptor subfamily 3, group C, member 1 isoform
alpha [Homo sapiens]
Length = 777
Score = 430 bits (1105), Expect = e-120
Identities = 214/390 (54%), Positives = 278/390 (71%), Gaps = 11/390 (2%)
Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
+RPD S S + P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457
Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
AGRNDCI+DKIRRKNCPACR RKC QAGM L RK KK K++ ++ GV
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508
Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
E+ T P QL P L++LL IEP+V+YAG+D++ PD++ ++T+LN LG
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568
Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+ S +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628
Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
+NEQRM Y C M + E +LQVS EE+LCMK LLLL+++P +GL+SQ F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688
Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV 903
+R +YI+EL KAI R+ + QRFYQLTKLLD++H++V+ L YC TF+ + +S+
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMSI 747
Query: 904 EFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
EFPEM++E+I Q+PK G +K LLFH+K
Sbjct: 748 EFPEMLAEIITNQIPKYSNGNIKKLLFHQK 777
>gi|66528677 nuclear receptor subfamily 3, group C, member 1 isoform
gamma [Homo sapiens]
Length = 778
Score = 425 bits (1093), Expect = e-119
Identities = 214/391 (54%), Positives = 278/391 (71%), Gaps = 12/391 (3%)
Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEG-QHNYL 602
+RPD S S + P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EG QHNYL
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYL 457
Query: 603 CAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGV 662
CAGRNDCI+DKIRRKNCPACR RKC QAGM L RK KK K++ ++ GV
Sbjct: 458 CAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GV 508
Query: 663 PNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLG 722
E+ T P QL P L++LL IEP+V+YAG+D++ PD++ ++T+LN LG
Sbjct: 509 SQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLG 568
Query: 723 ERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDL 782
RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+ S +L FAPDL
Sbjct: 569 GRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDL 628
Query: 783 ILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFE 842
I+NEQRM Y C M + E +LQVS EE+LCMK LLLL+++P +GL+SQ F+
Sbjct: 629 IINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFD 688
Query: 843 EMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALS 902
E+R +YI+EL KAI R+ + QRFYQLTKLLD++H++V+ L YC TF+ + +S
Sbjct: 689 EIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMS 747
Query: 903 VEFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
+EFPEM++E+I Q+PK G +K LLFH+K
Sbjct: 748 IEFPEMLAEIITNQIPKYSNGNIKKLLFHQK 778
>gi|66528642 nuclear receptor subfamily 3, group C, member 1 isoform
beta [Homo sapiens]
Length = 742
Score = 382 bits (981), Expect = e-106
Identities = 192/344 (55%), Positives = 244/344 (70%), Gaps = 10/344 (2%)
Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
+RPD S S + P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457
Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
AGRNDCI+DKIRRKNCPACR RKC QAGM L RK KK K++ ++ GV
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508
Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
E+ T P QL P L++LL IEP+V+YAG+D++ PD++ ++T+LN LG
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568
Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+ S +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628
Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
+NEQRM Y C M + E +LQVS EE+LCMK LLLL+++P +GL+SQ F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688
Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQL 887
+R +YI+EL KAI R+ + QRFYQLTKLLD++H+ V L
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHENVMWL 732
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 178 bits (452), Expect = 2e-44
Identities = 92/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)
Query: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
+Y ++P+++CL+CGD ASG HYGV +C +CK FFKR ++G Y C N+C + K R
Sbjct: 92 EYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 151
Query: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
RK+C ACR KC + GM+ G + + + + R LD+ +
Sbjct: 152 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSES------------------ 193
Query: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
SP +Q+ PP +++ L+ EPD +YA P+ LT+L L +R+L
Sbjct: 194 --SPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADREL 251
Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
+ ++ W+K +PGF +L + DQ++L+Q +WM +++ G+ +RS + L +A D I++E
Sbjct: 252 VVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPY--DDKLVYAEDYIMDE 309
Query: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
+ + + L + Q+ + + KL+V +EEF+ +K L L N+
Sbjct: 310 EHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANS 352
>gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens]
Length = 595
Score = 178 bits (452), Expect = 2e-44
Identities = 137/456 (30%), Positives = 223/456 (48%), Gaps = 72/456 (15%)
Query: 482 APGASGCLLPRDGLPSTSASAAAA------GAAPALY-----PALGLNGLPQL------- 523
A A+ + + GLP S AAA G P L P + L+ PQL
Sbjct: 65 AAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPH 124
Query: 524 GYQAAVLKEGLPQVY------PPYLNYLRPDSE------------ASQSPQYSFESLPQ- 564
G Q E P Y PP + RP+S+ + + ES +
Sbjct: 125 GQQVPYYLENEPSGYTVREAGPPA--FYRPNSDNRRQGGRERLASTNDKGSMAMESAKET 182
Query: 565 KICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRL 624
+ C +C D ASG HYGV +C CK FFKR+++G ++Y+C N C +DK RRK+C ACRL
Sbjct: 183 RYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRL 242
Query: 625 RKCCQAGMVLGG-RKFKKFNKV--------------RVVRALDAVAL---PQPVGVPNES 666
RKC + GM+ GG RK ++ ++ V A D A P P+ + S
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMI-KRS 301
Query: 667 QALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
+ S + + Q +++ L+ EP ++Y+ +D T+P + +S++ L L +R+L
Sbjct: 302 KKNSLALSLTADQ-------MVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354
Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
+ ++ W+K +PGF +L + DQ+ L++ +W+ +++ GL WRS +H G++L FAP+L+L+
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEH-PGKLL-FAPNLLLDR 412
Query: 787 QRMK-ESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMR 845
+ K + + F + + EEF+C+K ++LLN+ L S + E +
Sbjct: 413 NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEK 472
Query: 846 SSYIRELIK----AIGLRQKGVVSSSQRFYQLTKLL 877
R L K I L K ++ Q+ +L +LL
Sbjct: 473 DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL 508
>gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens]
Length = 595
Score = 178 bits (452), Expect = 2e-44
Identities = 137/456 (30%), Positives = 223/456 (48%), Gaps = 72/456 (15%)
Query: 482 APGASGCLLPRDGLPSTSASAAAA------GAAPALY-----PALGLNGLPQL------- 523
A A+ + + GLP S AAA G P L P + L+ PQL
Sbjct: 65 AAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPH 124
Query: 524 GYQAAVLKEGLPQVY------PPYLNYLRPDSE------------ASQSPQYSFESLPQ- 564
G Q E P Y PP + RP+S+ + + ES +
Sbjct: 125 GQQVPYYLENEPSGYTVREAGPPA--FYRPNSDNRRQGGRERLASTNDKGSMAMESAKET 182
Query: 565 KICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRL 624
+ C +C D ASG HYGV +C CK FFKR+++G ++Y+C N C +DK RRK+C ACRL
Sbjct: 183 RYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRL 242
Query: 625 RKCCQAGMVLGG-RKFKKFNKV--------------RVVRALDAVAL---PQPVGVPNES 666
RKC + GM+ GG RK ++ ++ V A D A P P+ + S
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMI-KRS 301
Query: 667 QALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
+ S + + Q +++ L+ EP ++Y+ +D T+P + +S++ L L +R+L
Sbjct: 302 KKNSLALSLTADQ-------MVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354
Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
+ ++ W+K +PGF +L + DQ+ L++ +W+ +++ GL WRS +H G++L FAP+L+L+
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEH-PGKLL-FAPNLLLDR 412
Query: 787 QRMK-ESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMR 845
+ K + + F + + EEF+C+K ++LLN+ L S + E +
Sbjct: 413 NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEK 472
Query: 846 SSYIRELIK----AIGLRQKGVVSSSQRFYQLTKLL 877
R L K I L K ++ Q+ +L +LL
Sbjct: 473 DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL 508
>gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens]
Length = 595
Score = 178 bits (452), Expect = 2e-44
Identities = 137/456 (30%), Positives = 223/456 (48%), Gaps = 72/456 (15%)
Query: 482 APGASGCLLPRDGLPSTSASAAAA------GAAPALY-----PALGLNGLPQL------- 523
A A+ + + GLP S AAA G P L P + L+ PQL
Sbjct: 65 AAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPH 124
Query: 524 GYQAAVLKEGLPQVY------PPYLNYLRPDSE------------ASQSPQYSFESLPQ- 564
G Q E P Y PP + RP+S+ + + ES +
Sbjct: 125 GQQVPYYLENEPSGYTVREAGPPA--FYRPNSDNRRQGGRERLASTNDKGSMAMESAKET 182
Query: 565 KICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRL 624
+ C +C D ASG HYGV +C CK FFKR+++G ++Y+C N C +DK RRK+C ACRL
Sbjct: 183 RYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRL 242
Query: 625 RKCCQAGMVLGG-RKFKKFNKV--------------RVVRALDAVAL---PQPVGVPNES 666
RKC + GM+ GG RK ++ ++ V A D A P P+ + S
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMI-KRS 301
Query: 667 QALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
+ S + + Q +++ L+ EP ++Y+ +D T+P + +S++ L L +R+L
Sbjct: 302 KKNSLALSLTADQ-------MVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354
Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
+ ++ W+K +PGF +L + DQ+ L++ +W+ +++ GL WRS +H G++L FAP+L+L+
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEH-PGKLL-FAPNLLLDR 412
Query: 787 QRMK-ESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMR 845
+ K + + F + + EEF+C+K ++LLN+ L S + E +
Sbjct: 413 NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEK 472
Query: 846 SSYIRELIK----AIGLRQKGVVSSSQRFYQLTKLL 877
R L K I L K ++ Q+ +L +LL
Sbjct: 473 DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL 508
>gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens]
Length = 595
Score = 178 bits (452), Expect = 2e-44
Identities = 137/456 (30%), Positives = 223/456 (48%), Gaps = 72/456 (15%)
Query: 482 APGASGCLLPRDGLPSTSASAAAA------GAAPALY-----PALGLNGLPQL------- 523
A A+ + + GLP S AAA G P L P + L+ PQL
Sbjct: 65 AAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPH 124
Query: 524 GYQAAVLKEGLPQVY------PPYLNYLRPDSE------------ASQSPQYSFESLPQ- 564
G Q E P Y PP + RP+S+ + + ES +
Sbjct: 125 GQQVPYYLENEPSGYTVREAGPPA--FYRPNSDNRRQGGRERLASTNDKGSMAMESAKET 182
Query: 565 KICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRL 624
+ C +C D ASG HYGV +C CK FFKR+++G ++Y+C N C +DK RRK+C ACRL
Sbjct: 183 RYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRL 242
Query: 625 RKCCQAGMVLGG-RKFKKFNKV--------------RVVRALDAVAL---PQPVGVPNES 666
RKC + GM+ GG RK ++ ++ V A D A P P+ + S
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMI-KRS 301
Query: 667 QALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
+ S + + Q +++ L+ EP ++Y+ +D T+P + +S++ L L +R+L
Sbjct: 302 KKNSLALSLTADQ-------MVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354
Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
+ ++ W+K +PGF +L + DQ+ L++ +W+ +++ GL WRS +H G++L FAP+L+L+
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEH-PGKLL-FAPNLLLDR 412
Query: 787 QRMK-ESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMR 845
+ K + + F + + EEF+C+K ++LLN+ L S + E +
Sbjct: 413 NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEK 472
Query: 846 SSYIRELIK----AIGLRQKGVVSSSQRFYQLTKLL 877
R L K I L K ++ Q+ +L +LL
Sbjct: 473 DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL 508
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 176 bits (446), Expect = 9e-44
Identities = 93/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)
Query: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
+Y S+P+++CL+CGD ASG HYGV +C +CK FFKR ++G Y C N+C + K R
Sbjct: 94 EYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 153
Query: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
RK+C ACR KC + GM+ G + + + + R +DA
Sbjct: 154 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDA-------------------- 193
Query: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
SP + QL+ P +++ L+ EP+ IYA D T PD+ LT+L L +R+L
Sbjct: 194 ENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADREL 253
Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
+ ++ W+K +PGF L + DQ++L+Q +WM +++ G+ +RS L +A D I++E
Sbjct: 254 VVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSF--EDELVYADDYIMDE 311
Query: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
+ K + L + Q+ +++ +++ +EEF+ +K + L N+
Sbjct: 312 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANS 354
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 176 bits (446), Expect = 9e-44
Identities = 93/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)
Query: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
+Y S+P+++CL+CGD ASG HYGV +C +CK FFKR ++G Y C N+C + K R
Sbjct: 94 EYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 153
Query: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
RK+C ACR KC + GM+ G + + + + R +DA
Sbjct: 154 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDA-------------------- 193
Query: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
SP + QL+ P +++ L+ EP+ IYA D T PD+ LT+L L +R+L
Sbjct: 194 ENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADREL 253
Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
+ ++ W+K +PGF L + DQ++L+Q +WM +++ G+ +RS L +A D I++E
Sbjct: 254 VVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSF--EDELVYADDYIMDE 311
Query: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
+ K + L + Q+ +++ +++ +EEF+ +K + L N+
Sbjct: 312 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANS 354
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 176 bits (446), Expect = 9e-44
Identities = 93/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)
Query: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
+Y S+P+++CL+CGD ASG HYGV +C +CK FFKR ++G Y C N+C + K R
Sbjct: 117 EYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 176
Query: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
RK+C ACR KC + GM+ G + + + + R +DA
Sbjct: 177 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDA-------------------- 216
Query: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
SP + QL+ P +++ L+ EP+ IYA D T PD+ LT+L L +R+L
Sbjct: 217 ENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADREL 276
Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
+ ++ W+K +PGF L + DQ++L+Q +WM +++ G+ +RS L +A D I++E
Sbjct: 277 VVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSF--EDELVYADDYIMDE 334
Query: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
+ K + L + Q+ +++ +++ +EEF+ +K + L N+
Sbjct: 335 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANS 377
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 176 bits (446), Expect = 9e-44
Identities = 93/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)
Query: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
+Y S+P+++CL+CGD ASG HYGV +C +CK FFKR ++G Y C N+C + K R
Sbjct: 94 EYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 153
Query: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
RK+C ACR KC + GM+ G + + + + R +DA
Sbjct: 154 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDA-------------------- 193
Query: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
SP + QL+ P +++ L+ EP+ IYA D T PD+ LT+L L +R+L
Sbjct: 194 ENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADREL 253
Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
+ ++ W+K +PGF L + DQ++L+Q +WM +++ G+ +RS L +A D I++E
Sbjct: 254 VVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSF--EDELVYADDYIMDE 311
Query: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
+ K + L + Q+ +++ +++ +EEF+ +K + L N+
Sbjct: 312 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANS 354
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 171 bits (434), Expect = 2e-42
Identities = 95/289 (32%), Positives = 157/289 (54%), Gaps = 14/289 (4%)
Query: 561 SLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCP 620
SLP+++CL+CGD ASG HYGV +C +CK FFKR ++G Y C N+C + K RRK C
Sbjct: 73 SLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQ 132
Query: 621 ACRLRKCCQAGMVLGGRKFKKF----NKVRVVRALDAVALPQPVGVPNESQALSQRFTFS 676
ACR KC + GM+ G + + K + +D + P P + A R T +
Sbjct: 133 ACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAA 192
Query: 677 PGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSL 736
P + L++ L+ +EP+ +YA D PD + +L L +R+++ + W+KS+
Sbjct: 193 P------VNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSI 246
Query: 737 PGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYS 796
PGF +L + DQ++++Q WM ++V G+ RS L FA DL+L+E+ + +
Sbjct: 247 PGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLP--LQDELAFAEDLVLDEEGARAAGLGE 304
Query: 797 LCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLN--TIPLEGLRSQTQFEE 843
L + Q+ + L++ +EE++ +K L L N ++ +E + Q E
Sbjct: 305 LGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLRE 353
>gi|94538328 estrogen receptor beta isoform 2 [Homo sapiens]
Length = 495
Score = 169 bits (428), Expect = 1e-41
Identities = 106/323 (32%), Positives = 167/323 (51%), Gaps = 24/323 (7%)
Query: 567 CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK 626
C +C D ASG HYGV +C CK FFKR+++G ++Y+C N C +DK RRK+C ACRLRK
Sbjct: 149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRK 208
Query: 627 CCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRF------TFSPGQD 680
C + GMV G + ++ V R A G S + R SP Q
Sbjct: 209 CYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQ- 267
Query: 681 IQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFR 740
L+ L+ EP + + P T +S++ SL +L +++L+ ++ W+K +PGF
Sbjct: 268 ------LVLTLLEAEPPHVLISRPSA-PFTEASMMMSLTKLADKELVHMISWAKKIPGFV 320
Query: 741 NLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK-ESSFYSLCL 799
L + DQ+ L++ WM +++ GL WRS H L FAPDL+L+ K +
Sbjct: 321 ELSLFDQVRLLESCWMEVLMMGLMWRSIDHPG--KLIFAPDLVLDRDEGKCVEGILEIFD 378
Query: 800 TMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKA---- 855
+ F +L++ +E+LC+K ++LLN+ + L + TQ + S + L+ A
Sbjct: 379 MLLATTSRFRELKLQHKEYLCVKAMILLNS-SMYPLVTATQ-DADSSRKLAHLLNAVTDA 436
Query: 856 -IGLRQKGVVSSSQRFYQLTKLL 877
+ + K +SS Q+ +L LL
Sbjct: 437 LVWVIAKSGISSQQQSMRLANLL 459
>gi|94538325 estrogen receptor beta isoform 2 [Homo sapiens]
Length = 495
Score = 169 bits (428), Expect = 1e-41
Identities = 106/323 (32%), Positives = 167/323 (51%), Gaps = 24/323 (7%)
Query: 567 CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK 626
C +C D ASG HYGV +C CK FFKR+++G ++Y+C N C +DK RRK+C ACRLRK
Sbjct: 149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRK 208
Query: 627 CCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRF------TFSPGQD 680
C + GMV G + ++ V R A G S + R SP Q
Sbjct: 209 CYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQ- 267
Query: 681 IQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFR 740
L+ L+ EP + + P T +S++ SL +L +++L+ ++ W+K +PGF
Sbjct: 268 ------LVLTLLEAEPPHVLISRPSA-PFTEASMMMSLTKLADKELVHMISWAKKIPGFV 320
Query: 741 NLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK-ESSFYSLCL 799
L + DQ+ L++ WM +++ GL WRS H L FAPDL+L+ K +
Sbjct: 321 ELSLFDQVRLLESCWMEVLMMGLMWRSIDHPG--KLIFAPDLVLDRDEGKCVEGILEIFD 378
Query: 800 TMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKA---- 855
+ F +L++ +E+LC+K ++LLN+ + L + TQ + S + L+ A
Sbjct: 379 MLLATTSRFRELKLQHKEYLCVKAMILLNS-SMYPLVTATQ-DADSSRKLAHLLNAVTDA 436
Query: 856 -IGLRQKGVVSSSQRFYQLTKLL 877
+ + K +SS Q+ +L LL
Sbjct: 437 LVWVIAKSGISSQQQSMRLANLL 459
>gi|10835013 estrogen receptor beta isoform 1 [Homo sapiens]
Length = 530
Score = 169 bits (428), Expect = 1e-41
Identities = 106/323 (32%), Positives = 167/323 (51%), Gaps = 24/323 (7%)
Query: 567 CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK 626
C +C D ASG HYGV +C CK FFKR+++G ++Y+C N C +DK RRK+C ACRLRK
Sbjct: 149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRK 208
Query: 627 CCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRF------TFSPGQD 680
C + GMV G + ++ V R A G S + R SP Q
Sbjct: 209 CYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQ- 267
Query: 681 IQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFR 740
L+ L+ EP + + P T +S++ SL +L +++L+ ++ W+K +PGF
Sbjct: 268 ------LVLTLLEAEPPHVLISRPSA-PFTEASMMMSLTKLADKELVHMISWAKKIPGFV 320
Query: 741 NLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK-ESSFYSLCL 799
L + DQ+ L++ WM +++ GL WRS H L FAPDL+L+ K +
Sbjct: 321 ELSLFDQVRLLESCWMEVLMMGLMWRSIDHPG--KLIFAPDLVLDRDEGKCVEGILEIFD 378
Query: 800 TMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKA---- 855
+ F +L++ +E+LC+K ++LLN+ + L + TQ + S + L+ A
Sbjct: 379 MLLATTSRFRELKLQHKEYLCVKAMILLNS-SMYPLVTATQ-DADSSRKLAHLLNAVTDA 436
Query: 856 -IGLRQKGVVSSSQRFYQLTKLL 877
+ + K +SS Q+ +L LL
Sbjct: 437 LVWVIAKSGISSQQQSMRLANLL 459
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 120 bits (301), Expect = 6e-27
Identities = 104/419 (24%), Positives = 179/419 (42%), Gaps = 52/419 (12%)
Query: 443 PASASVSSASSSGSTLECILYKAEGAPPQQGP-FAPPPCKAP---GASGCLLPRDGLPST 498
PA S + +++ + G P P + P AP A G L G P
Sbjct: 12 PAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYR 71
Query: 499 SASAAAAGAAPALYPALGLNGLPQLGYQAAVLKE-----------GLPQVYPPYLNYLRP 547
++A + AL G+N + Q V+ GLP + +NY
Sbjct: 72 VITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGI--GNMNY--- 126
Query: 548 DSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRN 607
P S SL + IC ICGD +SG HYGV +C CK FFKR + Y C
Sbjct: 127 -------PSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNK 179
Query: 608 DCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQ 667
DC++DK +R C CR +KC GM K V+ R + +
Sbjct: 180 DCLIDKRQRNRCQYCRYQKCLVMGM--------KREAVQEERQ------------RSRER 219
Query: 668 ALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLL 727
A S+ + G + + ++ +++EP G N + T+ +T++ ++QL
Sbjct: 220 AESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDP-VTNICHAADKQLF 278
Query: 728 SVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQ 787
++V+W+K +P F +L ++DQ+ L++ W L++ RS G +L A L ++
Sbjct: 279 TLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILL--ATGLHVHRS 336
Query: 788 RMKESSFYSLC-LTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMR 845
+ S+ + ++ + +Q+ + E C++ ++L N +GL + ++ E +R
Sbjct: 337 SAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP-DAKGLSNPSEVETLR 394
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 120 bits (300), Expect = 8e-27
Identities = 93/362 (25%), Positives = 155/362 (42%), Gaps = 54/362 (14%)
Query: 494 GLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQ 553
G P S+ ++ + P LGLNG VLK
Sbjct: 90 GSPQLSSPMNPVSSSEDIKPPLGLNG---------VLK-------------------VPA 121
Query: 554 SPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDK 613
P + S + IC ICGD +SG HYGV +C CK FFKR + Y C DC++DK
Sbjct: 122 HPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDK 181
Query: 614 IRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRF 673
+R C CR +KC GM K V+ R Q NE++ S
Sbjct: 182 RQRNRCQYCRYQKCLAMGM--------KREAVQEER--------QRGKDRNENEVES--- 222
Query: 674 TFSPGQDIQLIPPLINLLMSIEP--DVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVK 731
T S +D+ + ++ +++EP + + P + + +T++ Q ++QL ++V+
Sbjct: 223 TSSANEDMP-VERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVE 281
Query: 732 WSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK- 790
W+K +P F L +DDQ+ L++ W L++ RS G +L + N
Sbjct: 282 WAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAG 341
Query: 791 ESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIR 850
+ + LT ++ + +Q+ + E C++ ++L N +GL + + E +R
Sbjct: 342 VGAIFDRVLT--ELVSKMRDMQMDKTELGCLRAIVLFNP-DSKGLSNPAEVEALREKVYA 398
Query: 851 EL 852
L
Sbjct: 399 SL 400
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 120 bits (300), Expect = 8e-27
Identities = 115/467 (24%), Positives = 180/467 (38%), Gaps = 72/467 (15%)
Query: 392 EGAEASARSPRSYLVAGANPAAFPDFPLGPP-PPLPPRATPSRPGEAAVTAAPASASVSS 450
+G S R RS + NP P PP PPLPP PS G
Sbjct: 71 DGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGS-------------- 116
Query: 451 ASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPA 510
GAPP P PPP +P P S+S + G P
Sbjct: 117 ----------------GAPPPP-PMPPPPLGSP-----------FPVISSSMGSPGLPPP 148
Query: 511 LYPAL-GLNGLPQLGYQAAVLKEGL---PQVYPPYLNYLRPDSEASQSPQYSFESLPQKI 566
P G PQ+ ++ G V PP L P +++
Sbjct: 149 APPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGV----RGLHCPPPPGGPGAGKRL 204
Query: 567 CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK 626
C ICGD +SG HYGV +C CK FFKR + Y C DC VDK +R C CR +K
Sbjct: 205 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQK 264
Query: 627 CCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPP 686
C GM K + + R R D + G E + +++
Sbjct: 265 CLATGM-----KREAVQEER-QRGKDKDGDGEGAGGAPEEMPVD-----------RILEA 307
Query: 687 LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDD 746
+ + + V G + + +T++ Q ++QL ++V+W+K +P F +L +DD
Sbjct: 308 ELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDD 367
Query: 747 QITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK-ESSFYSLCLTMWQIP 805
Q+ L++ W L++ RS G +L + N + + LT ++
Sbjct: 368 QVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLT--ELV 425
Query: 806 QEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIREL 852
+ +++ + E C++ ++L N +GL + ++ E +R L
Sbjct: 426 SKMRDMRMDKTELGCLRAIILFNP-DAKGLSNPSEVEVLREKVYASL 471
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 118 bits (296), Expect = 2e-26
Identities = 92/349 (26%), Positives = 151/349 (43%), Gaps = 40/349 (11%)
Query: 544 YLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
Y DS A ++ + ++ +C ICGD A+G HYG +C CK FF+R++ H Y C
Sbjct: 26 YNSSDSSAPETSMNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSC 85
Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
C+VDK +R C CRLRKC +AGM + V
Sbjct: 86 RFSRQCVVDKDKRNQCRYCRLRKCFRAGM-------------------------KKEAVQ 120
Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIE--PDVIYAGHDNTKPDTSSSLLTSLNQL 721
NE +S R + G +I P IN L E I + D + + S+ +
Sbjct: 121 NERDRISTRRSTFDGSNI----PSINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDV 176
Query: 722 GE---RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYF 778
E +QLL +V+W+K +P F L +DDQ+ L++ ++ G RS + +L
Sbjct: 177 CESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLL 234
Query: 779 APDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQ 838
+ +++ + + ++ + F ++Q+ E+ C+K ++ + +GL
Sbjct: 235 GNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDP-DAKGLSDP 293
Query: 839 TQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQL 887
+ + MR L I RQ S RF +L LL L + Q+
Sbjct: 294 VKIKNMRFQVQIGLEDYINDRQ---YDSRGRFGELLLLLPTLQSITWQM 339
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 115 bits (287), Expect = 2e-25
Identities = 77/265 (29%), Positives = 118/265 (44%), Gaps = 15/265 (5%)
Query: 567 CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK 626
C++CGD++SG HYGV TC CK FFKR++ +Y C DC +D+ R C CRL+K
Sbjct: 56 CVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKK 115
Query: 627 CCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDI---QL 683
C + GM K V R +LP V + S S + G D+ Q
Sbjct: 116 CFRVGM----------RKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQP 165
Query: 684 IPPLINLLMSIEPDVIYAGHDNTKPDTSSSLL--TSLNQLGERQLLSVVKWSKSLPGFRN 741
+ LI L+ EP AG + ++L ++ +L R L S V+W++ P F
Sbjct: 166 VSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPE 225
Query: 742 LHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTM 801
L + DQ+ L++ SW L V + + +L A + +F
Sbjct: 226 LPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAF 285
Query: 802 WQIPQEFVKLQVSQEEFLCMKVLLL 826
+ + +LQV E+ C+K + L
Sbjct: 286 QEQVDKLGRLQVDSAEYGCLKAIAL 310
>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
b [Homo sapiens]
Length = 637
Score = 111 bits (278), Expect = 3e-24
Identities = 102/380 (26%), Positives = 154/380 (40%), Gaps = 35/380 (9%)
Query: 401 PRSYLVAGANPAAFPDFPLGPPPP--LPPRATPSRPGEAAVTAAPASASVSSASSSGSTL 458
P + + +P + P P PP L A PS PG + P A + +
Sbjct: 140 PSTSMYFKQSPPSTPTTPAFPPQAGALWDEALPSAPG--CIAPGPLLDPPMKAVPTVAGA 197
Query: 459 ECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLN 518
L+ + +PP PP +P A G L D + + S AA A A L
Sbjct: 198 RFPLFHFKPSPPH------PPAPSP-AGGHHLGYDPTAAAALSLPLGAAAAAGSQAAALE 250
Query: 519 GLPQLGYQAAVLKEGLPQVYPPY-------LNYLRPDSEASQSPQYSFESLPQKICLICG 571
P Y + K P +PP + L +S + SP S + C +CG
Sbjct: 251 SHP---YGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCG 307
Query: 572 DEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAG 631
D A+ HYGV TC CK FFKR ++ Y+C +C VDK RR C CR +KC G
Sbjct: 308 DNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVG 367
Query: 632 MVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLL 691
MV ++ + + ++ R LP P + + P I ++ L+ L
Sbjct: 368 MV---KEVVRTDSLKGRRG----RLPSKPKSPLQQEPSQPS---PPSPPICMMNALVRAL 417
Query: 692 MSIEP-DVIYAGH---DNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQ 747
P D+ Y+ + D T + + L + W++ +PGF +L +DQ
Sbjct: 418 TDSTPRDLDYSRYCPTDQAAAGTDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQ 477
Query: 748 ITLIQYSWMSLMVFGLGWRS 767
LI+ +++ L V L RS
Sbjct: 478 TLLIESAFLELFVLRLSIRS 497
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,852,323
Number of Sequences: 37866
Number of extensions: 2545180
Number of successful extensions: 25843
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 232
Number of HSP's successfully gapped in prelim test: 1134
Number of HSP's that attempted gapping in prelim test: 17939
Number of HSP's gapped (non-prelim): 6678
length of query: 933
length of database: 18,247,518
effective HSP length: 112
effective length of query: 821
effective length of database: 14,006,526
effective search space: 11499357846
effective search space used: 11499357846
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.