Guide to the Human Genome
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Search of human proteins with 110611914

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110611914 progesterone receptor [Homo sapiens]
         (933 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110611914 progesterone receptor [Homo sapiens]                    1878   0.0  
gi|21322252 androgen receptor isoform 1 [Homo sapiens]                449   e-126
gi|158508572 nuclear receptor subfamily 3, group C, member 2 [Ho...   443   e-124
gi|58535455 androgen receptor isoform 2 [Homo sapiens]                441   e-123
gi|66528611 nuclear receptor subfamily 3, group C, member 1 isof...   430   e-120
gi|66528586 nuclear receptor subfamily 3, group C, member 1 isof...   430   e-120
gi|66528563 nuclear receptor subfamily 3, group C, member 1 isof...   430   e-120
gi|66528530 nuclear receptor subfamily 3, group C, member 1 isof...   430   e-120
gi|4504133 nuclear receptor subfamily 3, group C, member 1 isofo...   430   e-120
gi|66528677 nuclear receptor subfamily 3, group C, member 1 isof...   425   e-119
gi|66528642 nuclear receptor subfamily 3, group C, member 1 isof...   382   e-106
gi|238550159 estrogen-related receptor beta [Homo sapiens]            178   2e-44
gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens]         178   2e-44
gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens]         178   2e-44
gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens]         178   2e-44
gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens]          178   2e-44
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi...   176   9e-44
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi...   176   9e-44
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi...   176   9e-44
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap...   176   9e-44
gi|18860920 estrogen-related receptor alpha [Homo sapiens]            171   2e-42
gi|94538328 estrogen receptor beta isoform 2 [Homo sapiens]           169   1e-41
gi|94538325 estrogen receptor beta isoform 2 [Homo sapiens]           169   1e-41
gi|10835013 estrogen receptor beta isoform 1 [Homo sapiens]           169   1e-41
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]        120   6e-27
gi|4506755 retinoid X receptor, alpha [Homo sapiens]                  120   8e-27
gi|11415052 retinoid X receptor, beta [Homo sapiens]                  120   8e-27
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]        118   2e-26
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom...   115   2e-25
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof...   111   3e-24

>gi|110611914 progesterone receptor [Homo sapiens]
          Length = 933

 Score = 1878 bits (4866), Expect = 0.0
 Identities = 933/933 (100%), Positives = 933/933 (100%)

Query: 1   MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF 60
           MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
Sbjct: 1   MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF 60

Query: 61  PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA 120
           PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
Sbjct: 61  PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA 120

Query: 121 PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA 180
           PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
Sbjct: 121 PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA 180

Query: 181 AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK 240
           AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
Sbjct: 181 AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK 240

Query: 241 PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV 300
           PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
Sbjct: 241 PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV 300

Query: 301 MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD 360
           MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
Sbjct: 301 MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD 360

Query: 361 CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG 420
           CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
Sbjct: 361 CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG 420

Query: 421 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC 480
           PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
Sbjct: 421 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC 480

Query: 481 KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP 540
           KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
Sbjct: 481 KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP 540

Query: 541 YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN 600
           YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
Sbjct: 541 YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN 600

Query: 601 YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV 660
           YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
Sbjct: 601 YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV 660

Query: 661 GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ 720
           GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
Sbjct: 661 GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ 720

Query: 721 LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP 780
           LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
Sbjct: 721 LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP 780

Query: 781 DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ 840
           DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
Sbjct: 781 DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ 840

Query: 841 FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA 900
           FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
Sbjct: 841 FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA 900

Query: 901 LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
           LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
Sbjct: 901 LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933


>gi|21322252 androgen receptor isoform 1 [Homo sapiens]
          Length = 920

 Score =  449 bits (1155), Expect = e-126
 Identities = 335/951 (35%), Positives = 458/951 (48%), Gaps = 146/951 (15%)

Query: 49  SAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDS 108
           SA P     LL  +  Q Q    ++ Q QQ     E +  + +  +G  GS  +     +
Sbjct: 46  SAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPT 105

Query: 109 GLLDSVLDTLLAPSGPGQSQ---------PSPPACEVTSSWCLFGPELP----EDPPAAP 155
           G L  VLD    PS P  +          P P A    S       +LP    ED  AAP
Sbjct: 106 GYL--VLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKG--LPQQLPAPPDEDDSAAP 161

Query: 156 ATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQ 215
           +T  +L P         G SS +A    +L    +   QLL                  Q
Sbjct: 162 STLSLLGPTFP------GLSSCSADLKDILSE--ASTMQLL---------------QQQQ 198

Query: 216 AAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRF 275
             AV      G   E S  P    K   LGG +     A     A +  + L        
Sbjct: 199 QEAVSEGSSSGRAREASGAPT-SSKDNYLGGTSTISDNAKELCKAVSVSMGLG------- 250

Query: 276 SAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDES--YDGGA 333
                  VE    ++PG         D ++ P+L +  A+       L E +    D  A
Sbjct: 251 -------VEALEHLSPGEQLRG----DCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSA 299

Query: 334 GAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEG 393
           G ++      S      T    G+   C+    A              P  L + +    
Sbjct: 300 GKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLE------LPSTLSLYKSGAL 353

Query: 394 AEASARSPRSYLVAGANPAAFPDFPL---GPPPPLPP---------------------RA 429
            EA+A   R Y           +FPL   GPPPP PP                      A
Sbjct: 354 DEAAAYQSRDYY----------NFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAA 403

Query: 430 TPSRPGEAAV-----TAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPG 484
              R G+ A       A P S S S+A+SS       L+ AE     +G    P C   G
Sbjct: 404 AQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHT---LFTAE-----EGQLYGP-CGGGG 454

Query: 485 ASGCLLPRDGLPSTSASAAAAGA-APALY--PALGLNG------LPQLGYQAAVLKEGLP 535
             G      G          AGA AP  Y  P  GL G       P + Y   ++   +P
Sbjct: 455 GGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSR-VP 513

Query: 536 QVYP--------PYLNY-------LRPDSEASQSPQYSFESLPQKICLICGDEASGCHYG 580
              P        P+++        +R ++         +   PQK CLICGDEASGCHYG
Sbjct: 514 YPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYG 573

Query: 581 VLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFK 640
            LTCGSCKVFFKRA EG+  YLCA RNDC +DK RRKNCP+CRLRKC +AGM LG RK K
Sbjct: 574 ALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLK 633

Query: 641 KFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIY 700
           K   +++    +A +   P      ++  +Q+ T S  +  +  P  +N+L +IEP V+ 
Sbjct: 634 KLGNLKLQEEGEASSTTSP------TEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVC 687

Query: 701 AGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMV 760
           AGHDN +PD+ ++LL+SLN+LGERQL+ VVKW+K+LPGFRNLH+DDQ+ +IQYSWM LMV
Sbjct: 688 AGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMV 747

Query: 761 FGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLC 820
           F +GWRS+ +V+ +MLYFAPDL+ NE RM +S  YS C+ M  + QEF  LQ++ +EFLC
Sbjct: 748 FAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLC 807

Query: 821 MKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNL 880
           MK LLL + IP++GL++Q  F+E+R +YI+EL + I  ++K   S S+RFYQLTKLLD++
Sbjct: 808 MKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSV 867

Query: 881 HDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFH 931
             + ++LH +  +  I+S  +SV+FPEMM+E+I+ Q+PKIL+G VKP+ FH
Sbjct: 868 QPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH 918


>gi|158508572 nuclear receptor subfamily 3, group C, member 2 [Homo
           sapiens]
          Length = 984

 Score =  443 bits (1139), Expect = e-124
 Identities = 223/411 (54%), Positives = 289/411 (70%), Gaps = 18/411 (4%)

Query: 540 PYLNYLRPDSEASQSPQYSF-ESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQ 598
           P L Y+  +  +S     S   S P KICL+CGDEASGCHYGV+TCGSCKVFFKRA+EGQ
Sbjct: 575 PVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQ 634

Query: 599 HNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQ 658
           HNYLCAGRNDCI+DKIRRKNCPACRL+KC QAGM LG RK KK  K++ +   +     Q
Sbjct: 635 HNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHE-EQPQQQQ 693

Query: 659 PVGVPNESQALSQRFTF-----SPGQDIQLIPPL-----------INLLMSIEPDVIYAG 702
           P   P   Q+  +  T+      P  +  L+P L           + +L +IEP+++YAG
Sbjct: 694 PPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAG 753

Query: 703 HDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFG 762
           +D++KPDT+ +LL++LN+L  +Q++ VVKW+K LPGF+NL ++DQITLIQYSWM L  F 
Sbjct: 754 YDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFA 813

Query: 763 LGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMK 822
           L WRSYKH + Q LYFAPDL+ NE++M +S+ Y LC  M QI  +FV+LQ++ EE+  MK
Sbjct: 814 LSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMK 873

Query: 823 VLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHD 882
           VLLLL+TIP +GL+SQ  FEEMR++YI+EL K +         S QRFYQLTKLLD++HD
Sbjct: 874 VLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHD 933

Query: 883 LVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
           LV  L  +C  TF +S AL VEFP M+ E+I+ QLPK+ +G  KPL FH+K
Sbjct: 934 LVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK 984


>gi|58535455 androgen receptor isoform 2 [Homo sapiens]
          Length = 388

 Score =  441 bits (1133), Expect = e-123
 Identities = 205/369 (55%), Positives = 277/369 (75%), Gaps = 6/369 (1%)

Query: 563 PQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPAC 622
           PQK CLICGDEASGCHYG LTCGSCKVFFKRA EG+  YLCA RNDC +DK RRKNCP+C
Sbjct: 24  PQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSC 83

Query: 623 RLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQ 682
           RLRKC +AGM LG RK KK   +++    +A +   P      ++  +Q+ T S  +  +
Sbjct: 84  RLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSP------TEETTQKLTVSHIEGYE 137

Query: 683 LIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNL 742
             P  +N+L +IEP V+ AGHDN +PD+ ++LL+SLN+LGERQL+ VVKW+K+LPGFRNL
Sbjct: 138 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNL 197

Query: 743 HIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMW 802
           H+DDQ+ +IQYSWM LMVF +GWRS+ +V+ +MLYFAPDL+ NE RM +S  YS C+ M 
Sbjct: 198 HVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMR 257

Query: 803 QIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKG 862
            + QEF  LQ++ +EFLCMK LLL + IP++GL++Q  F+E+R +YI+EL + I  ++K 
Sbjct: 258 HLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKN 317

Query: 863 VVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILA 922
             S S+RFYQLTKLLD++  + ++LH +  +  I+S  +SV+FPEMM+E+I+ Q+PKIL+
Sbjct: 318 PTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILS 377

Query: 923 GMVKPLLFH 931
           G VKP+ FH
Sbjct: 378 GKVKPIYFH 386


>gi|66528611 nuclear receptor subfamily 3, group C, member 1 isoform
           alpha [Homo sapiens]
          Length = 777

 Score =  430 bits (1105), Expect = e-120
 Identities = 214/390 (54%), Positives = 278/390 (71%), Gaps = 11/390 (2%)

Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
           +RPD S    S   +    P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457

Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
           AGRNDCI+DKIRRKNCPACR RKC QAGM L  RK KK  K++ ++           GV 
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508

Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
            E+       T  P    QL P L++LL  IEP+V+YAG+D++ PD++  ++T+LN LG 
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568

Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
           RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+  S  +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628

Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
           +NEQRM     Y  C  M  +  E  +LQVS EE+LCMK LLLL+++P +GL+SQ  F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688

Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV 903
           +R +YI+EL KAI  R+     + QRFYQLTKLLD++H++V+ L  YC  TF+  + +S+
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMSI 747

Query: 904 EFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
           EFPEM++E+I  Q+PK   G +K LLFH+K
Sbjct: 748 EFPEMLAEIITNQIPKYSNGNIKKLLFHQK 777


>gi|66528586 nuclear receptor subfamily 3, group C, member 1 isoform
           alpha [Homo sapiens]
          Length = 777

 Score =  430 bits (1105), Expect = e-120
 Identities = 214/390 (54%), Positives = 278/390 (71%), Gaps = 11/390 (2%)

Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
           +RPD S    S   +    P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457

Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
           AGRNDCI+DKIRRKNCPACR RKC QAGM L  RK KK  K++ ++           GV 
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508

Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
            E+       T  P    QL P L++LL  IEP+V+YAG+D++ PD++  ++T+LN LG 
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568

Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
           RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+  S  +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628

Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
           +NEQRM     Y  C  M  +  E  +LQVS EE+LCMK LLLL+++P +GL+SQ  F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688

Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV 903
           +R +YI+EL KAI  R+     + QRFYQLTKLLD++H++V+ L  YC  TF+  + +S+
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMSI 747

Query: 904 EFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
           EFPEM++E+I  Q+PK   G +K LLFH+K
Sbjct: 748 EFPEMLAEIITNQIPKYSNGNIKKLLFHQK 777


>gi|66528563 nuclear receptor subfamily 3, group C, member 1 isoform
           alpha [Homo sapiens]
          Length = 777

 Score =  430 bits (1105), Expect = e-120
 Identities = 214/390 (54%), Positives = 278/390 (71%), Gaps = 11/390 (2%)

Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
           +RPD S    S   +    P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457

Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
           AGRNDCI+DKIRRKNCPACR RKC QAGM L  RK KK  K++ ++           GV 
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508

Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
            E+       T  P    QL P L++LL  IEP+V+YAG+D++ PD++  ++T+LN LG 
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568

Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
           RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+  S  +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628

Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
           +NEQRM     Y  C  M  +  E  +LQVS EE+LCMK LLLL+++P +GL+SQ  F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688

Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV 903
           +R +YI+EL KAI  R+     + QRFYQLTKLLD++H++V+ L  YC  TF+  + +S+
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMSI 747

Query: 904 EFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
           EFPEM++E+I  Q+PK   G +K LLFH+K
Sbjct: 748 EFPEMLAEIITNQIPKYSNGNIKKLLFHQK 777


>gi|66528530 nuclear receptor subfamily 3, group C, member 1 isoform
           alpha [Homo sapiens]
          Length = 777

 Score =  430 bits (1105), Expect = e-120
 Identities = 214/390 (54%), Positives = 278/390 (71%), Gaps = 11/390 (2%)

Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
           +RPD S    S   +    P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457

Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
           AGRNDCI+DKIRRKNCPACR RKC QAGM L  RK KK  K++ ++           GV 
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508

Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
            E+       T  P    QL P L++LL  IEP+V+YAG+D++ PD++  ++T+LN LG 
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568

Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
           RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+  S  +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628

Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
           +NEQRM     Y  C  M  +  E  +LQVS EE+LCMK LLLL+++P +GL+SQ  F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688

Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV 903
           +R +YI+EL KAI  R+     + QRFYQLTKLLD++H++V+ L  YC  TF+  + +S+
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMSI 747

Query: 904 EFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
           EFPEM++E+I  Q+PK   G +K LLFH+K
Sbjct: 748 EFPEMLAEIITNQIPKYSNGNIKKLLFHQK 777


>gi|4504133 nuclear receptor subfamily 3, group C, member 1 isoform
           alpha [Homo sapiens]
          Length = 777

 Score =  430 bits (1105), Expect = e-120
 Identities = 214/390 (54%), Positives = 278/390 (71%), Gaps = 11/390 (2%)

Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
           +RPD S    S   +    P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457

Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
           AGRNDCI+DKIRRKNCPACR RKC QAGM L  RK KK  K++ ++           GV 
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508

Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
            E+       T  P    QL P L++LL  IEP+V+YAG+D++ PD++  ++T+LN LG 
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568

Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
           RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+  S  +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628

Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
           +NEQRM     Y  C  M  +  E  +LQVS EE+LCMK LLLL+++P +GL+SQ  F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688

Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV 903
           +R +YI+EL KAI  R+     + QRFYQLTKLLD++H++V+ L  YC  TF+  + +S+
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMSI 747

Query: 904 EFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
           EFPEM++E+I  Q+PK   G +K LLFH+K
Sbjct: 748 EFPEMLAEIITNQIPKYSNGNIKKLLFHQK 777


>gi|66528677 nuclear receptor subfamily 3, group C, member 1 isoform
           gamma [Homo sapiens]
          Length = 778

 Score =  425 bits (1093), Expect = e-119
 Identities = 214/391 (54%), Positives = 278/391 (71%), Gaps = 12/391 (3%)

Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEG-QHNYL 602
           +RPD S    S   +    P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EG QHNYL
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYL 457

Query: 603 CAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGV 662
           CAGRNDCI+DKIRRKNCPACR RKC QAGM L  RK KK  K++ ++           GV
Sbjct: 458 CAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GV 508

Query: 663 PNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLG 722
             E+       T  P    QL P L++LL  IEP+V+YAG+D++ PD++  ++T+LN LG
Sbjct: 509 SQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLG 568

Query: 723 ERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDL 782
            RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+  S  +L FAPDL
Sbjct: 569 GRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDL 628

Query: 783 ILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFE 842
           I+NEQRM     Y  C  M  +  E  +LQVS EE+LCMK LLLL+++P +GL+SQ  F+
Sbjct: 629 IINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFD 688

Query: 843 EMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALS 902
           E+R +YI+EL KAI  R+     + QRFYQLTKLLD++H++V+ L  YC  TF+  + +S
Sbjct: 689 EIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFL-DKTMS 747

Query: 903 VEFPEMMSEVIAAQLPKILAGMVKPLLFHKK 933
           +EFPEM++E+I  Q+PK   G +K LLFH+K
Sbjct: 748 IEFPEMLAEIITNQIPKYSNGNIKKLLFHQK 778


>gi|66528642 nuclear receptor subfamily 3, group C, member 1 isoform
           beta [Homo sapiens]
          Length = 742

 Score =  382 bits (981), Expect = e-106
 Identities = 192/344 (55%), Positives = 244/344 (70%), Gaps = 10/344 (2%)

Query: 545 LRPD-SEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
           +RPD S    S   +    P K+CL+C DEASGCHYGVLTCGSCKVFFKRA+EGQHNYLC
Sbjct: 398 MRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLC 457

Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
           AGRNDCI+DKIRRKNCPACR RKC QAGM L  RK KK  K++ ++           GV 
Sbjct: 458 AGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKK--KIKGIQQATT-------GVS 508

Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE 723
            E+       T  P    QL P L++LL  IEP+V+YAG+D++ PD++  ++T+LN LG 
Sbjct: 509 QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGG 568

Query: 724 RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI 783
           RQ+++ VKW+K++PGFRNLH+DDQ+TL+QYSWM LM F LGWRSY+  S  +L FAPDLI
Sbjct: 569 RQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI 628

Query: 784 LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEE 843
           +NEQRM     Y  C  M  +  E  +LQVS EE+LCMK LLLL+++P +GL+SQ  F+E
Sbjct: 629 INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDE 688

Query: 844 MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQL 887
           +R +YI+EL KAI  R+     + QRFYQLTKLLD++H+ V  L
Sbjct: 689 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHENVMWL 732


>gi|238550159 estrogen-related receptor beta [Homo sapiens]
          Length = 508

 Score =  178 bits (452), Expect = 2e-44
 Identities = 92/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)

Query: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
           +Y   ++P+++CL+CGD ASG HYGV +C +CK FFKR ++G   Y C   N+C + K R
Sbjct: 92  EYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 151

Query: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
           RK+C ACR  KC + GM+  G +  +    + +  R LD+ +                  
Sbjct: 152 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSES------------------ 193

Query: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
             SP   +Q+ PP       +++ L+  EPD +YA      P+     LT+L  L +R+L
Sbjct: 194 --SPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADREL 251

Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
           + ++ W+K +PGF +L + DQ++L+Q +WM +++ G+ +RS  +     L +A D I++E
Sbjct: 252 VVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPY--DDKLVYAEDYIMDE 309

Query: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
           +  + +    L   + Q+ + + KL+V +EEF+ +K L L N+
Sbjct: 310 EHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANS 352


>gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens]
          Length = 595

 Score =  178 bits (452), Expect = 2e-44
 Identities = 137/456 (30%), Positives = 223/456 (48%), Gaps = 72/456 (15%)

Query: 482 APGASGCLLPRDGLPSTSASAAAA------GAAPALY-----PALGLNGLPQL------- 523
           A  A+  +  + GLP    S AAA      G  P L      P + L+  PQL       
Sbjct: 65  AAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPH 124

Query: 524 GYQAAVLKEGLPQVY------PPYLNYLRPDSE------------ASQSPQYSFESLPQ- 564
           G Q     E  P  Y      PP   + RP+S+             +     + ES  + 
Sbjct: 125 GQQVPYYLENEPSGYTVREAGPPA--FYRPNSDNRRQGGRERLASTNDKGSMAMESAKET 182

Query: 565 KICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRL 624
           + C +C D ASG HYGV +C  CK FFKR+++G ++Y+C   N C +DK RRK+C ACRL
Sbjct: 183 RYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRL 242

Query: 625 RKCCQAGMVLGG-RKFKKFNKV--------------RVVRALDAVAL---PQPVGVPNES 666
           RKC + GM+ GG RK ++  ++               V  A D  A    P P+ +   S
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMI-KRS 301

Query: 667 QALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
           +  S   + +  Q       +++ L+  EP ++Y+ +D T+P + +S++  L  L +R+L
Sbjct: 302 KKNSLALSLTADQ-------MVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354

Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
           + ++ W+K +PGF +L + DQ+ L++ +W+ +++ GL WRS +H  G++L FAP+L+L+ 
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEH-PGKLL-FAPNLLLDR 412

Query: 787 QRMK-ESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMR 845
            + K       +   +      F  + +  EEF+C+K ++LLN+     L S  +  E +
Sbjct: 413 NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEK 472

Query: 846 SSYIRELIK----AIGLRQKGVVSSSQRFYQLTKLL 877
               R L K     I L  K  ++  Q+  +L +LL
Sbjct: 473 DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL 508


>gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens]
          Length = 595

 Score =  178 bits (452), Expect = 2e-44
 Identities = 137/456 (30%), Positives = 223/456 (48%), Gaps = 72/456 (15%)

Query: 482 APGASGCLLPRDGLPSTSASAAAA------GAAPALY-----PALGLNGLPQL------- 523
           A  A+  +  + GLP    S AAA      G  P L      P + L+  PQL       
Sbjct: 65  AAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPH 124

Query: 524 GYQAAVLKEGLPQVY------PPYLNYLRPDSE------------ASQSPQYSFESLPQ- 564
           G Q     E  P  Y      PP   + RP+S+             +     + ES  + 
Sbjct: 125 GQQVPYYLENEPSGYTVREAGPPA--FYRPNSDNRRQGGRERLASTNDKGSMAMESAKET 182

Query: 565 KICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRL 624
           + C +C D ASG HYGV +C  CK FFKR+++G ++Y+C   N C +DK RRK+C ACRL
Sbjct: 183 RYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRL 242

Query: 625 RKCCQAGMVLGG-RKFKKFNKV--------------RVVRALDAVAL---PQPVGVPNES 666
           RKC + GM+ GG RK ++  ++               V  A D  A    P P+ +   S
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMI-KRS 301

Query: 667 QALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
           +  S   + +  Q       +++ L+  EP ++Y+ +D T+P + +S++  L  L +R+L
Sbjct: 302 KKNSLALSLTADQ-------MVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354

Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
           + ++ W+K +PGF +L + DQ+ L++ +W+ +++ GL WRS +H  G++L FAP+L+L+ 
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEH-PGKLL-FAPNLLLDR 412

Query: 787 QRMK-ESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMR 845
            + K       +   +      F  + +  EEF+C+K ++LLN+     L S  +  E +
Sbjct: 413 NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEK 472

Query: 846 SSYIRELIK----AIGLRQKGVVSSSQRFYQLTKLL 877
               R L K     I L  K  ++  Q+  +L +LL
Sbjct: 473 DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL 508


>gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens]
          Length = 595

 Score =  178 bits (452), Expect = 2e-44
 Identities = 137/456 (30%), Positives = 223/456 (48%), Gaps = 72/456 (15%)

Query: 482 APGASGCLLPRDGLPSTSASAAAA------GAAPALY-----PALGLNGLPQL------- 523
           A  A+  +  + GLP    S AAA      G  P L      P + L+  PQL       
Sbjct: 65  AAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPH 124

Query: 524 GYQAAVLKEGLPQVY------PPYLNYLRPDSE------------ASQSPQYSFESLPQ- 564
           G Q     E  P  Y      PP   + RP+S+             +     + ES  + 
Sbjct: 125 GQQVPYYLENEPSGYTVREAGPPA--FYRPNSDNRRQGGRERLASTNDKGSMAMESAKET 182

Query: 565 KICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRL 624
           + C +C D ASG HYGV +C  CK FFKR+++G ++Y+C   N C +DK RRK+C ACRL
Sbjct: 183 RYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRL 242

Query: 625 RKCCQAGMVLGG-RKFKKFNKV--------------RVVRALDAVAL---PQPVGVPNES 666
           RKC + GM+ GG RK ++  ++               V  A D  A    P P+ +   S
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMI-KRS 301

Query: 667 QALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
           +  S   + +  Q       +++ L+  EP ++Y+ +D T+P + +S++  L  L +R+L
Sbjct: 302 KKNSLALSLTADQ-------MVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354

Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
           + ++ W+K +PGF +L + DQ+ L++ +W+ +++ GL WRS +H  G++L FAP+L+L+ 
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEH-PGKLL-FAPNLLLDR 412

Query: 787 QRMK-ESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMR 845
            + K       +   +      F  + +  EEF+C+K ++LLN+     L S  +  E +
Sbjct: 413 NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEK 472

Query: 846 SSYIRELIK----AIGLRQKGVVSSSQRFYQLTKLL 877
               R L K     I L  K  ++  Q+  +L +LL
Sbjct: 473 DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL 508


>gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens]
          Length = 595

 Score =  178 bits (452), Expect = 2e-44
 Identities = 137/456 (30%), Positives = 223/456 (48%), Gaps = 72/456 (15%)

Query: 482 APGASGCLLPRDGLPSTSASAAAA------GAAPALY-----PALGLNGLPQL------- 523
           A  A+  +  + GLP    S AAA      G  P L      P + L+  PQL       
Sbjct: 65  AAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPH 124

Query: 524 GYQAAVLKEGLPQVY------PPYLNYLRPDSE------------ASQSPQYSFESLPQ- 564
           G Q     E  P  Y      PP   + RP+S+             +     + ES  + 
Sbjct: 125 GQQVPYYLENEPSGYTVREAGPPA--FYRPNSDNRRQGGRERLASTNDKGSMAMESAKET 182

Query: 565 KICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRL 624
           + C +C D ASG HYGV +C  CK FFKR+++G ++Y+C   N C +DK RRK+C ACRL
Sbjct: 183 RYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRL 242

Query: 625 RKCCQAGMVLGG-RKFKKFNKV--------------RVVRALDAVAL---PQPVGVPNES 666
           RKC + GM+ GG RK ++  ++               V  A D  A    P P+ +   S
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMI-KRS 301

Query: 667 QALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
           +  S   + +  Q       +++ L+  EP ++Y+ +D T+P + +S++  L  L +R+L
Sbjct: 302 KKNSLALSLTADQ-------MVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354

Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
           + ++ W+K +PGF +L + DQ+ L++ +W+ +++ GL WRS +H  G++L FAP+L+L+ 
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEH-PGKLL-FAPNLLLDR 412

Query: 787 QRMK-ESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMR 845
            + K       +   +      F  + +  EEF+C+K ++LLN+     L S  +  E +
Sbjct: 413 NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEK 472

Query: 846 SSYIRELIK----AIGLRQKGVVSSSQRFYQLTKLL 877
               R L K     I L  K  ++  Q+  +L +LL
Sbjct: 473 DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL 508


>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  176 bits (446), Expect = 9e-44
 Identities = 93/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)

Query: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
           +Y   S+P+++CL+CGD ASG HYGV +C +CK FFKR ++G   Y C   N+C + K R
Sbjct: 94  EYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 153

Query: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
           RK+C ACR  KC + GM+  G +  +    + +  R +DA                    
Sbjct: 154 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDA-------------------- 193

Query: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
             SP  + QL+ P       +++ L+  EP+ IYA  D T PD+    LT+L  L +R+L
Sbjct: 194 ENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADREL 253

Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
           + ++ W+K +PGF  L + DQ++L+Q +WM +++ G+ +RS        L +A D I++E
Sbjct: 254 VVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSF--EDELVYADDYIMDE 311

Query: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
            + K +    L   + Q+ +++  +++ +EEF+ +K + L N+
Sbjct: 312 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANS 354


>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  176 bits (446), Expect = 9e-44
 Identities = 93/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)

Query: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
           +Y   S+P+++CL+CGD ASG HYGV +C +CK FFKR ++G   Y C   N+C + K R
Sbjct: 94  EYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 153

Query: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
           RK+C ACR  KC + GM+  G +  +    + +  R +DA                    
Sbjct: 154 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDA-------------------- 193

Query: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
             SP  + QL+ P       +++ L+  EP+ IYA  D T PD+    LT+L  L +R+L
Sbjct: 194 ENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADREL 253

Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
           + ++ W+K +PGF  L + DQ++L+Q +WM +++ G+ +RS        L +A D I++E
Sbjct: 254 VVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSF--EDELVYADDYIMDE 311

Query: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
            + K +    L   + Q+ +++  +++ +EEF+ +K + L N+
Sbjct: 312 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANS 354


>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
           sapiens]
          Length = 458

 Score =  176 bits (446), Expect = 9e-44
 Identities = 93/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)

Query: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
           +Y   S+P+++CL+CGD ASG HYGV +C +CK FFKR ++G   Y C   N+C + K R
Sbjct: 117 EYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 176

Query: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
           RK+C ACR  KC + GM+  G +  +    + +  R +DA                    
Sbjct: 177 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDA-------------------- 216

Query: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
             SP  + QL+ P       +++ L+  EP+ IYA  D T PD+    LT+L  L +R+L
Sbjct: 217 ENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADREL 276

Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
           + ++ W+K +PGF  L + DQ++L+Q +WM +++ G+ +RS        L +A D I++E
Sbjct: 277 VVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSF--EDELVYADDYIMDE 334

Query: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
            + K +    L   + Q+ +++  +++ +EEF+ +K + L N+
Sbjct: 335 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANS 377


>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  176 bits (446), Expect = 9e-44
 Identities = 93/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)

Query: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
           +Y   S+P+++CL+CGD ASG HYGV +C +CK FFKR ++G   Y C   N+C + K R
Sbjct: 94  EYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 153

Query: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
           RK+C ACR  KC + GM+  G +  +    + +  R +DA                    
Sbjct: 154 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDA-------------------- 193

Query: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
             SP  + QL+ P       +++ L+  EP+ IYA  D T PD+    LT+L  L +R+L
Sbjct: 194 ENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADREL 253

Query: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
           + ++ W+K +PGF  L + DQ++L+Q +WM +++ G+ +RS        L +A D I++E
Sbjct: 254 VVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSF--EDELVYADDYIMDE 311

Query: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
            + K +    L   + Q+ +++  +++ +EEF+ +K + L N+
Sbjct: 312 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANS 354


>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
          Length = 423

 Score =  171 bits (434), Expect = 2e-42
 Identities = 95/289 (32%), Positives = 157/289 (54%), Gaps = 14/289 (4%)

Query: 561 SLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCP 620
           SLP+++CL+CGD ASG HYGV +C +CK FFKR ++G   Y C   N+C + K RRK C 
Sbjct: 73  SLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQ 132

Query: 621 ACRLRKCCQAGMVLGGRKFKKF----NKVRVVRALDAVALPQPVGVPNESQALSQRFTFS 676
           ACR  KC + GM+  G +  +      K +    +D +  P P      + A   R T +
Sbjct: 133 ACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAA 192

Query: 677 PGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSL 736
           P      +  L++ L+ +EP+ +YA  D   PD     + +L  L +R+++  + W+KS+
Sbjct: 193 P------VNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSI 246

Query: 737 PGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYS 796
           PGF +L + DQ++++Q  WM ++V G+  RS        L FA DL+L+E+  + +    
Sbjct: 247 PGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLP--LQDELAFAEDLVLDEEGARAAGLGE 304

Query: 797 LCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLN--TIPLEGLRSQTQFEE 843
           L   + Q+ +    L++ +EE++ +K L L N  ++ +E   +  Q  E
Sbjct: 305 LGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLRE 353


>gi|94538328 estrogen receptor beta isoform 2 [Homo sapiens]
          Length = 495

 Score =  169 bits (428), Expect = 1e-41
 Identities = 106/323 (32%), Positives = 167/323 (51%), Gaps = 24/323 (7%)

Query: 567 CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK 626
           C +C D ASG HYGV +C  CK FFKR+++G ++Y+C   N C +DK RRK+C ACRLRK
Sbjct: 149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRK 208

Query: 627 CCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRF------TFSPGQD 680
           C + GMV  G + ++     V R   A       G    S   + R         SP Q 
Sbjct: 209 CYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQ- 267

Query: 681 IQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFR 740
                 L+  L+  EP  +     +  P T +S++ SL +L +++L+ ++ W+K +PGF 
Sbjct: 268 ------LVLTLLEAEPPHVLISRPSA-PFTEASMMMSLTKLADKELVHMISWAKKIPGFV 320

Query: 741 NLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK-ESSFYSLCL 799
            L + DQ+ L++  WM +++ GL WRS  H     L FAPDL+L+    K       +  
Sbjct: 321 ELSLFDQVRLLESCWMEVLMMGLMWRSIDHPG--KLIFAPDLVLDRDEGKCVEGILEIFD 378

Query: 800 TMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKA---- 855
            +      F +L++  +E+LC+K ++LLN+  +  L + TQ +   S  +  L+ A    
Sbjct: 379 MLLATTSRFRELKLQHKEYLCVKAMILLNS-SMYPLVTATQ-DADSSRKLAHLLNAVTDA 436

Query: 856 -IGLRQKGVVSSSQRFYQLTKLL 877
            + +  K  +SS Q+  +L  LL
Sbjct: 437 LVWVIAKSGISSQQQSMRLANLL 459


>gi|94538325 estrogen receptor beta isoform 2 [Homo sapiens]
          Length = 495

 Score =  169 bits (428), Expect = 1e-41
 Identities = 106/323 (32%), Positives = 167/323 (51%), Gaps = 24/323 (7%)

Query: 567 CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK 626
           C +C D ASG HYGV +C  CK FFKR+++G ++Y+C   N C +DK RRK+C ACRLRK
Sbjct: 149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRK 208

Query: 627 CCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRF------TFSPGQD 680
           C + GMV  G + ++     V R   A       G    S   + R         SP Q 
Sbjct: 209 CYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQ- 267

Query: 681 IQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFR 740
                 L+  L+  EP  +     +  P T +S++ SL +L +++L+ ++ W+K +PGF 
Sbjct: 268 ------LVLTLLEAEPPHVLISRPSA-PFTEASMMMSLTKLADKELVHMISWAKKIPGFV 320

Query: 741 NLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK-ESSFYSLCL 799
            L + DQ+ L++  WM +++ GL WRS  H     L FAPDL+L+    K       +  
Sbjct: 321 ELSLFDQVRLLESCWMEVLMMGLMWRSIDHPG--KLIFAPDLVLDRDEGKCVEGILEIFD 378

Query: 800 TMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKA---- 855
            +      F +L++  +E+LC+K ++LLN+  +  L + TQ +   S  +  L+ A    
Sbjct: 379 MLLATTSRFRELKLQHKEYLCVKAMILLNS-SMYPLVTATQ-DADSSRKLAHLLNAVTDA 436

Query: 856 -IGLRQKGVVSSSQRFYQLTKLL 877
            + +  K  +SS Q+  +L  LL
Sbjct: 437 LVWVIAKSGISSQQQSMRLANLL 459


>gi|10835013 estrogen receptor beta isoform 1 [Homo sapiens]
          Length = 530

 Score =  169 bits (428), Expect = 1e-41
 Identities = 106/323 (32%), Positives = 167/323 (51%), Gaps = 24/323 (7%)

Query: 567 CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK 626
           C +C D ASG HYGV +C  CK FFKR+++G ++Y+C   N C +DK RRK+C ACRLRK
Sbjct: 149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRK 208

Query: 627 CCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRF------TFSPGQD 680
           C + GMV  G + ++     V R   A       G    S   + R         SP Q 
Sbjct: 209 CYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQ- 267

Query: 681 IQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFR 740
                 L+  L+  EP  +     +  P T +S++ SL +L +++L+ ++ W+K +PGF 
Sbjct: 268 ------LVLTLLEAEPPHVLISRPSA-PFTEASMMMSLTKLADKELVHMISWAKKIPGFV 320

Query: 741 NLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK-ESSFYSLCL 799
            L + DQ+ L++  WM +++ GL WRS  H     L FAPDL+L+    K       +  
Sbjct: 321 ELSLFDQVRLLESCWMEVLMMGLMWRSIDHPG--KLIFAPDLVLDRDEGKCVEGILEIFD 378

Query: 800 TMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKA---- 855
            +      F +L++  +E+LC+K ++LLN+  +  L + TQ +   S  +  L+ A    
Sbjct: 379 MLLATTSRFRELKLQHKEYLCVKAMILLNS-SMYPLVTATQ-DADSSRKLAHLLNAVTDA 436

Query: 856 -IGLRQKGVVSSSQRFYQLTKLL 877
            + +  K  +SS Q+  +L  LL
Sbjct: 437 LVWVIAKSGISSQQQSMRLANLL 459


>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
          Length = 463

 Score =  120 bits (301), Expect = 6e-27
 Identities = 104/419 (24%), Positives = 179/419 (42%), Gaps = 52/419 (12%)

Query: 443 PASASVSSASSSGSTLECILYKAEGAPPQQGP-FAPPPCKAP---GASGCLLPRDGLPST 498
           PA    S   +  +++      + G P    P +   P  AP    A G  L   G P  
Sbjct: 12  PAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYR 71

Query: 499 SASAAAAGAAPALYPALGLNGLPQLGYQAAVLKE-----------GLPQVYPPYLNYLRP 547
             ++A    + AL    G+N +     Q  V+             GLP +    +NY   
Sbjct: 72  VITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGI--GNMNY--- 126

Query: 548 DSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRN 607
                  P  S  SL + IC ICGD +SG HYGV +C  CK FFKR +     Y C    
Sbjct: 127 -------PSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNK 179

Query: 608 DCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQ 667
           DC++DK +R  C  CR +KC   GM        K   V+  R              +  +
Sbjct: 180 DCLIDKRQRNRCQYCRYQKCLVMGM--------KREAVQEERQ------------RSRER 219

Query: 668 ALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLL 727
           A S+    + G +   +  ++   +++EP     G  N +  T+   +T++    ++QL 
Sbjct: 220 AESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDP-VTNICHAADKQLF 278

Query: 728 SVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQ 787
           ++V+W+K +P F +L ++DQ+ L++  W  L++     RS     G +L  A  L ++  
Sbjct: 279 TLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILL--ATGLHVHRS 336

Query: 788 RMKESSFYSLC-LTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMR 845
               +   S+    + ++  +   +Q+ + E  C++ ++L N    +GL + ++ E +R
Sbjct: 337 SAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP-DAKGLSNPSEVETLR 394


>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
          Length = 462

 Score =  120 bits (300), Expect = 8e-27
 Identities = 93/362 (25%), Positives = 155/362 (42%), Gaps = 54/362 (14%)

Query: 494 GLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQ 553
           G P  S+      ++  + P LGLNG         VLK                      
Sbjct: 90  GSPQLSSPMNPVSSSEDIKPPLGLNG---------VLK-------------------VPA 121

Query: 554 SPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDK 613
            P  +  S  + IC ICGD +SG HYGV +C  CK FFKR +     Y C    DC++DK
Sbjct: 122 HPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDK 181

Query: 614 IRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRF 673
            +R  C  CR +KC   GM        K   V+  R        Q     NE++  S   
Sbjct: 182 RQRNRCQYCRYQKCLAMGM--------KREAVQEER--------QRGKDRNENEVES--- 222

Query: 674 TFSPGQDIQLIPPLINLLMSIEP--DVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVK 731
           T S  +D+  +  ++   +++EP  +     +    P + +  +T++ Q  ++QL ++V+
Sbjct: 223 TSSANEDMP-VERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVE 281

Query: 732 WSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK- 790
           W+K +P F  L +DDQ+ L++  W  L++     RS     G +L     +  N      
Sbjct: 282 WAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAG 341

Query: 791 ESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIR 850
             + +   LT  ++  +   +Q+ + E  C++ ++L N    +GL +  + E +R     
Sbjct: 342 VGAIFDRVLT--ELVSKMRDMQMDKTELGCLRAIVLFNP-DSKGLSNPAEVEALREKVYA 398

Query: 851 EL 852
            L
Sbjct: 399 SL 400


>gi|11415052 retinoid X receptor, beta [Homo sapiens]
          Length = 533

 Score =  120 bits (300), Expect = 8e-27
 Identities = 115/467 (24%), Positives = 180/467 (38%), Gaps = 72/467 (15%)

Query: 392 EGAEASARSPRSYLVAGANPAAFPDFPLGPP-PPLPPRATPSRPGEAAVTAAPASASVSS 450
           +G   S R  RS   +  NP      P  PP PPLPP   PS  G               
Sbjct: 71  DGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGS-------------- 116

Query: 451 ASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPA 510
                           GAPP   P  PPP  +P            P  S+S  + G  P 
Sbjct: 117 ----------------GAPPPP-PMPPPPLGSP-----------FPVISSSMGSPGLPPP 148

Query: 511 LYPAL-GLNGLPQLGYQAAVLKEGL---PQVYPPYLNYLRPDSEASQSPQYSFESLPQKI 566
             P   G    PQ+    ++   G      V PP L            P        +++
Sbjct: 149 APPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGV----RGLHCPPPPGGPGAGKRL 204

Query: 567 CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK 626
           C ICGD +SG HYGV +C  CK FFKR +     Y C    DC VDK +R  C  CR +K
Sbjct: 205 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQK 264

Query: 627 CCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPP 686
           C   GM     K +   + R  R  D     +  G   E   +            +++  
Sbjct: 265 CLATGM-----KREAVQEER-QRGKDKDGDGEGAGGAPEEMPVD-----------RILEA 307

Query: 687 LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDD 746
            + +    +  V   G       + +  +T++ Q  ++QL ++V+W+K +P F +L +DD
Sbjct: 308 ELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDD 367

Query: 747 QITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK-ESSFYSLCLTMWQIP 805
           Q+ L++  W  L++     RS     G +L     +  N        + +   LT  ++ 
Sbjct: 368 QVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLT--ELV 425

Query: 806 QEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIREL 852
            +   +++ + E  C++ ++L N    +GL + ++ E +R      L
Sbjct: 426 SKMRDMRMDKTELGCLRAIILFNP-DAKGLSNPSEVEVLREKVYASL 471


>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
          Length = 445

 Score =  118 bits (296), Expect = 2e-26
 Identities = 92/349 (26%), Positives = 151/349 (43%), Gaps = 40/349 (11%)

Query: 544 YLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLC 603
           Y   DS A ++   + ++    +C ICGD A+G HYG  +C  CK FF+R++   H Y C
Sbjct: 26  YNSSDSSAPETSMNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSC 85

Query: 604 AGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVP 663
                C+VDK +R  C  CRLRKC +AGM                         +   V 
Sbjct: 86  RFSRQCVVDKDKRNQCRYCRLRKCFRAGM-------------------------KKEAVQ 120

Query: 664 NESQALSQRFTFSPGQDIQLIPPLINLLMSIE--PDVIYAGHDNTKPDTSSSLLTSLNQL 721
           NE   +S R +   G +I    P IN L   E     I      +  D +   + S+  +
Sbjct: 121 NERDRISTRRSTFDGSNI----PSINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDV 176

Query: 722 GE---RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYF 778
            E   +QLL +V+W+K +P F  L +DDQ+ L++      ++ G   RS  +    +L  
Sbjct: 177 CESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLL 234

Query: 779 APDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQ 838
             + +++    +          + ++ + F ++Q+   E+ C+K ++  +    +GL   
Sbjct: 235 GNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDP-DAKGLSDP 293

Query: 839 TQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQL 887
            + + MR      L   I  RQ     S  RF +L  LL  L  +  Q+
Sbjct: 294 VKIKNMRFQVQIGLEDYINDRQ---YDSRGRFGELLLLLPTLQSITWQM 339


>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
           sapiens]
          Length = 404

 Score =  115 bits (287), Expect = 2e-25
 Identities = 77/265 (29%), Positives = 118/265 (44%), Gaps = 15/265 (5%)

Query: 567 CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK 626
           C++CGD++SG HYGV TC  CK FFKR++    +Y C    DC +D+  R  C  CRL+K
Sbjct: 56  CVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKK 115

Query: 627 CCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDI---QL 683
           C + GM           K  V R     +LP  V   + S   S     + G D+   Q 
Sbjct: 116 CFRVGM----------RKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQP 165

Query: 684 IPPLINLLMSIEPDVIYAGHDNTKPDTSSSLL--TSLNQLGERQLLSVVKWSKSLPGFRN 741
           +  LI  L+  EP    AG        + ++L   ++ +L  R L S V+W++  P F  
Sbjct: 166 VSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPE 225

Query: 742 LHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTM 801
           L + DQ+ L++ SW  L V      +    +  +L  A          +  +F       
Sbjct: 226 LPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAF 285

Query: 802 WQIPQEFVKLQVSQEEFLCMKVLLL 826
            +   +  +LQV   E+ C+K + L
Sbjct: 286 QEQVDKLGRLQVDSAEYGCLKAIAL 310


>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
           b [Homo sapiens]
          Length = 637

 Score =  111 bits (278), Expect = 3e-24
 Identities = 102/380 (26%), Positives = 154/380 (40%), Gaps = 35/380 (9%)

Query: 401 PRSYLVAGANPAAFPDFPLGPPPP--LPPRATPSRPGEAAVTAAPASASVSSASSSGSTL 458
           P + +    +P + P  P  PP    L   A PS PG   +   P       A  + +  
Sbjct: 140 PSTSMYFKQSPPSTPTTPAFPPQAGALWDEALPSAPG--CIAPGPLLDPPMKAVPTVAGA 197

Query: 459 ECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLN 518
              L+  + +PP       PP  +P A G  L  D   + + S     AA A   A  L 
Sbjct: 198 RFPLFHFKPSPPH------PPAPSP-AGGHHLGYDPTAAAALSLPLGAAAAAGSQAAALE 250

Query: 519 GLPQLGYQAAVLKEGLPQVYPPY-------LNYLRPDSEASQSPQYSFESLPQKICLICG 571
             P   Y   + K   P  +PP         + L  +S +  SP     S  +  C +CG
Sbjct: 251 SHP---YGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCG 307

Query: 572 DEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAG 631
           D A+  HYGV TC  CK FFKR ++    Y+C    +C VDK RR  C  CR +KC   G
Sbjct: 308 DNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVG 367

Query: 632 MVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLL 691
           MV   ++  + + ++  R      LP     P + +         P   I ++  L+  L
Sbjct: 368 MV---KEVVRTDSLKGRRG----RLPSKPKSPLQQEPSQPS---PPSPPICMMNALVRAL 417

Query: 692 MSIEP-DVIYAGH---DNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQ 747
               P D+ Y+ +   D     T +  +     L    +     W++ +PGF +L  +DQ
Sbjct: 418 TDSTPRDLDYSRYCPTDQAAAGTDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQ 477

Query: 748 ITLIQYSWMSLMVFGLGWRS 767
             LI+ +++ L V  L  RS
Sbjct: 478 TLLIESAFLELFVLRLSIRS 497


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,852,323
Number of Sequences: 37866
Number of extensions: 2545180
Number of successful extensions: 25843
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 232
Number of HSP's successfully gapped in prelim test: 1134
Number of HSP's that attempted gapping in prelim test: 17939
Number of HSP's gapped (non-prelim): 6678
length of query: 933
length of database: 18,247,518
effective HSP length: 112
effective length of query: 821
effective length of database: 14,006,526
effective search space: 11499357846
effective search space used: 11499357846
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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