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Search of human proteins with 16751843
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16751843 toll-like receptor 5 [Homo sapiens]
(858 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16751843 toll-like receptor 5 [Homo sapiens] 1731 0.0
gi|4507531 toll-like receptor 3 [Homo sapiens] 201 2e-51
gi|7706093 toll-like receptor 7 [Homo sapiens] 192 1e-48
gi|20302168 toll-like receptor 8 [Homo sapiens] 179 7e-45
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 167 3e-41
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 152 1e-36
gi|62865621 toll-like receptor 10 precursor [Homo sapiens] 140 7e-33
gi|62865618 toll-like receptor 10 precursor [Homo sapiens] 140 7e-33
gi|19718734 toll-like receptor 2 [Homo sapiens] 132 2e-30
gi|20143971 toll-like receptor 6 [Homo sapiens] 130 7e-30
gi|41350337 toll-like receptor 1 [Homo sapiens] 125 2e-28
gi|225579152 insulin-like growth factor binding protein, acid la... 110 4e-24
gi|4826772 insulin-like growth factor binding protein, acid labi... 110 4e-24
gi|11321571 slit homolog 3 [Homo sapiens] 108 3e-23
gi|188528675 slit homolog 1 [Homo sapiens] 107 4e-23
gi|198041768 synleurin [Homo sapiens] 104 4e-22
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 100 1e-20
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 99 2e-20
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 98 4e-20
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 97 8e-20
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 96 1e-19
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 96 2e-19
gi|167555127 CD180 molecule [Homo sapiens] 93 1e-18
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 92 3e-18
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 92 3e-18
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 91 3e-18
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 91 3e-18
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 91 5e-18
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 87 7e-17
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 86 1e-16
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 1731 bits (4482), Expect = 0.0
Identities = 858/858 (100%), Positives = 858/858 (100%)
Query: 1 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 60
MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
Sbjct: 1 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 60
Query: 61 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 120
VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
Sbjct: 61 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 120
Query: 121 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 180
LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
Sbjct: 121 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 180
Query: 181 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 240
QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
Sbjct: 181 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 240
Query: 241 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 300
DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
Sbjct: 241 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 300
Query: 301 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 360
FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
Sbjct: 301 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 360
Query: 361 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 420
KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
Sbjct: 361 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 420
Query: 421 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 480
INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
Sbjct: 421 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 480
Query: 481 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 540
GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
Sbjct: 481 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 540
Query: 541 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 600
LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
Sbjct: 541 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 600
Query: 601 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 660
IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
Sbjct: 601 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 660
Query: 661 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 720
TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
Sbjct: 661 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 720
Query: 721 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 780
DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
Sbjct: 721 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 780
Query: 781 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 840
SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
Sbjct: 781 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 840
Query: 841 KEKKKDNNIPLQTVATIS 858
KEKKKDNNIPLQTVATIS
Sbjct: 841 KEKKKDNNIPLQTVATIS 858
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 201 bits (512), Expect = 2e-51
Identities = 232/889 (26%), Positives = 387/889 (43%), Gaps = 103/889 (11%)
Query: 24 CSFDGRIAFYRFCNLTQVPQVLNTTERLL-LSFNYIRTVTASSFPFLEQLQLLELGSQYT 82
C+ +A LTQVP L T +L L+ N +R + A++F QL L++G T
Sbjct: 28 CTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFN-T 86
Query: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV--LKDGY 140
++ E + LP L++L+L +++ L F +L EL L +S+++ +K+
Sbjct: 87 ISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHL----MSNSIQKIKNNP 142
Query: 141 FRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLS- 199
F K L LDLS N + S L +L +L+ + S+N+I + EL+ +L
Sbjct: 143 FVKQKNLITLDLSHNGLSSTKLGTQV-QLENLQELLLSNNKIQALKSEELDIFANSSLKK 201
Query: 200 ---------------------FFSLAANSLYSRVSVDWGKCMN----PFRNMVLEILDVS 234
F L N++ S+ C+ RN+ L +S
Sbjct: 202 LELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLS 261
Query: 235 --------GNGWT----VDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTF 282
G WT +D++ N N + L + ++NI+ ++
Sbjct: 262 TTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFF---LEYNNIQHLFSHSL 318
Query: 283 AGLARSSVRHLDLSHGFVFS---------LNSRVFETLKDLKVLNLAYNKINKIADEAFY 333
GL +VR+L+L F ++ F+ LK L+ LN+ N I I F
Sbjct: 319 HGLF--NVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFT 376
Query: 334 GLDNLQVLNLS--YNLLGELYSSNFYGLPK--VAYIDLQKNHIAIIQDQTFKFLEKLQTL 389
GL NL+ L+LS + L L + F L + ++L KN I+ I+ F +L L+ L
Sbjct: 377 GLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVL 436
Query: 390 DLRDNAL------TTIHFIPSIPDIFLSGNKLVTLPKIN--LTANLIHLSENR--LENLD 439
DL N + + +I +I+LS NK + L + + L +L L R L+N+D
Sbjct: 437 DLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVD 496
Query: 440 ILYFLLR-VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWD-- 496
+ + +L IL L+ N ++ + D LE L L N L W+
Sbjct: 497 SSPSPFQPLRNLTILDLSNNNIANINDDMLEGLE-KLEILDLQHNNLARLWKHANPGGPI 555
Query: 497 -VFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHN--DLPANLEIL 553
+GLSHL +L L N + +P VF L L+ + L N L L + + +L+ L
Sbjct: 556 YFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSL 615
Query: 554 DISRNQLLAPNPDVFV----SLSVLDITHNKFICECE-LSTFINWLNHTNVTIAGPPADI 608
++ +N + + VF +L+ LD+ N F C CE ++ F+NW+N T+ I +
Sbjct: 616 NLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHY 675
Query: 609 YCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCF 668
C P + G + T C + S F LF + ++ L + I+ + F G+
Sbjct: 676 LCNTPPHYHGFPVRLFDTSSCKD-----SAPFELFFMINTSILLIFIFIVLLIHFEGWRI 730
Query: 669 ICY---KTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRF 725
Y + L FK+ + TE ++Y AY+ + KD WV +H + +
Sbjct: 731 SFYWNVSVHRVLGFKEIDRQTE--QFEYAAYIIHAYKDKDWVW----EHFSSMEKEDQSL 784
Query: 726 NLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLE-AFSYAQGRCLSDLN 784
C EERDF G + I ++I SRKI+ +++ H L+D C +A + +
Sbjct: 785 KFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNL 844
Query: 785 SALIMVVVGSLSQYQLMKHQSI-RGFVQKQQYLRWPEDLQDVGWFLHKL 832
++I+V + + Y+L + RG + L WP + +G F HKL
Sbjct: 845 DSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKL 893
Score = 76.3 bits (186), Expect = 1e-13
Identities = 81/306 (26%), Positives = 137/306 (44%), Gaps = 33/306 (10%)
Query: 282 FAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLK----VLNLAYNKINKIADEAFYGLDN 337
F L SS +SH + ++ + DL VLNL +N++ ++ F
Sbjct: 17 FGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQ 76
Query: 338 LQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALT 397
L L++ +N + +L LP + ++LQ N ++ + D+TF F L L L N++
Sbjct: 77 LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQ 136
Query: 398 TIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQ 457
I P F+ L+TL LS N L + L +++ +LQ L+L+
Sbjct: 137 KIKNNP-----FVKQKNLITL----------DLSHNGLSSTK-LGTQVQLENLQELLLSN 180
Query: 458 NRFSSCSGDQTP-SENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLN- 515
N+ + ++ N SL++L L N ++ E F + L L+LN+ L
Sbjct: 181 NKIQALKSEELDIFANSSLKKLELSSNQIK-----EFSPGCFHAIGRLFGLFLNNVQLGP 235
Query: 516 SLPPGVFSHL--TALRGLSLNSNRLTVLSHNDLP----ANLEILDISRNQLLAPNPDVFV 569
SL + L T++R LSL++++L+ S+ NL +LD+S N L D F
Sbjct: 236 SLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFA 295
Query: 570 SLSVLD 575
L L+
Sbjct: 296 WLPQLE 301
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 192 bits (487), Expect = 1e-48
Identities = 214/859 (24%), Positives = 367/859 (42%), Gaps = 115/859 (13%)
Query: 37 NLTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQY-------------- 81
N+T VP VL +T L L N I + F L QLQ+L+L
Sbjct: 215 NVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCK 274
Query: 82 --TPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDG 139
+PL I AF L L++L L S+ + + P F+ + L EL L L+ +
Sbjct: 275 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAK 334
Query: 140 YFRNLKALTRLDLSKNQIRSLY-----LHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQ 194
+ L +L +LDLS N +Y L +F L SLK + + L PL
Sbjct: 335 FLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLH 394
Query: 195 G-KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKS 253
+ L L N + ++ K + + L + +S +G + ++ G SNA +
Sbjct: 395 NLQNLEVLDLGTNFI-KIANLSMFKQFKRLKVIDLSVNKISPSGDSSEV-GFCSNARTSV 452
Query: 254 QAFS---LILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRH---LDLSHGFVFSLNSRV 307
+++ L H+ + + +F + S ++ LDLS +F + S
Sbjct: 453 ESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSD 512
Query: 308 FETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDL 367
F+ L LK LNL+ N I+ Q LN S F L ++ Y+D
Sbjct: 513 FQHLSFLKCLNLSGNLIS-------------QTLN----------GSEFQPLAELRYLDF 549
Query: 368 QKNHIAIIQDQTFKFLEKLQTLDLRDNA-----------LTTIHFIPSIPDIFLSGNKLV 416
N + ++ F+ L KL+ LD+ N+ L + + + ++ N +
Sbjct: 550 SNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDIS 609
Query: 417 TLPKINLTANLIHLSENRLENLDILY---------FLLRVPHLQILILNQNRFSSCSGDQ 467
+ + + + E R +LD+L+ + L+ L +++N S
Sbjct: 610 SSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGV 669
Query: 468 TPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527
P+L+ L L +N L+ W + L +L+ L L+HN L ++P + + +
Sbjct: 670 FDGMPPNLKNLSLAKNGLK-----SFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRS 724
Query: 528 LRGLSLNSNRLTVLSHNDLPA--NLEILDISRNQLLAPNP-----DVFVSLSVLDITHNK 580
L+ L L +N++ L+ L L LD+S N++ +V +L +L + HN+
Sbjct: 725 LKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNR 784
Query: 581 FICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKF 640
F+C C+ F+ W+NHT VTI D+ CV P + G S+ SL C E ++ + F
Sbjct: 785 FLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTC-ELDLTNLILF 843
Query: 641 SLFIVCTVTLTLFLMTILT--------VTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYK 692
SL +++++LFLM ++T V FC K QRL+ PD
Sbjct: 844 SL----SISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLI--------SPDCC- 890
Query: 693 YDAYLCFSSKD---FTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIW 749
YDA++ + +KD WV L+ L+ + FNLC EERD++PG+ + N+ +I
Sbjct: 891 YDAFIVYDTKDPAVTEWVLAELVAKLED--PREKHFNLCLEERDWLPGQPVLENLSQSIQ 948
Query: 750 NSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGF 809
S+K V +++ + + AF + R + + +I++ + +Q K +R
Sbjct: 949 LSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLE--KPFQKSKFLQLRKR 1006
Query: 810 VQKQQYLRWPEDLQDVGWF 828
+ L WP + Q +F
Sbjct: 1007 LCGSSVLEWPTNPQAHPYF 1025
Score = 53.1 bits (126), Expect = 1e-06
Identities = 78/335 (23%), Positives = 128/335 (38%), Gaps = 42/335 (12%)
Query: 23 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 82
SC F + A + N + L LS N I V +S F L L+ L L
Sbjct: 474 SCRFKNKEASFMSVN----ESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLI 529
Query: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 142
T++ F+ L LR LD ++++ LH AF+ L L L D YF+
Sbjct: 530 SQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVL--------DISSNSHYFQ 581
Query: 143 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS 202
+ L+ +KN L L+ + + N I +E +TL F
Sbjct: 582 SEGITHMLNFTKN-------------LKVLQKLMMNDNDISSSTSRTMESESLRTLEFRG 628
Query: 203 LAANSLYSRVSVDWGKCMNPFRNMV-LEILDVSGNGWTVDITGNFSNAISKSQAFSLILA 261
+ L+ + + F+N++ LE LD+S N + +G F + SL
Sbjct: 629 NHLDVLWREGD---NRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAK- 684
Query: 262 HHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAY 321
+ +K L ++ LDLSH + ++ R+ + LK L L
Sbjct: 685 ----------NGLKSFSWKKLQCL--KNLETLDLSHNQLTTVPERLSNCSRSLKNLILKN 732
Query: 322 NKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNF 356
N+I + L+ L+LS N + + ++F
Sbjct: 733 NQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSF 767
Score = 49.7 bits (117), Expect = 1e-05
Identities = 78/307 (25%), Positives = 121/307 (39%), Gaps = 38/307 (12%)
Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
S++ L L +FS+ L ++++L L N + Y ++ LNL+ +
Sbjct: 149 SLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKV 208
Query: 349 GELYSSNFYGLPKV-----AYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHF-I 402
L +N +P V + L N IA IQ+ F L +LQ LDL N +
Sbjct: 209 LSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPF 268
Query: 403 PSIPDIFLSGNKLVTLPKINLTA----NLIHLSENRLENLDILYFLLRVPHLQILILNQN 458
P P N + +P A ++ L N L+++ +F + LQ L L+QN
Sbjct: 269 PCAP---CKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFK-NINKLQELDLSQN 324
Query: 459 RFSSCSGDQTPSEN-PSLEQLFLGENM-LQLAWETELCWDVFEGLSHLQVLYLNHNYLNS 516
+ GD PSL QL L N LQ+ + F L L++L +
Sbjct: 325 FLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKE 384
Query: 517 LPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVS---LSV 573
L S L L+ NLE+LD+ N + N +F L V
Sbjct: 385 LKSFNLSPLHNLQ-------------------NLEVLDLGTNFIKIANLSMFKQFKRLKV 425
Query: 574 LDITHNK 580
+D++ NK
Sbjct: 426 IDLSVNK 432
Score = 40.0 bits (92), Expect = 0.009
Identities = 57/210 (27%), Positives = 93/210 (44%), Gaps = 21/210 (10%)
Query: 358 GLP-KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLV 416
G+P + L NHI I +F L+ L +D R N + IP + +L
Sbjct: 62 GIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVP----IPLGSKNNMCIKRLQ 117
Query: 417 TLPKINLTANLIHLSENRLENLDILYFLLRV-PHLQILILNQNRFSSCSGDQTPSENPSL 475
P+ + L +L L+ +L + P LQ+L L N S + +E ++
Sbjct: 118 IKPR--SFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENL-TELANI 174
Query: 476 EQLFLGENM-----LQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRG 530
E L+LG+N +++ E D F L+ L+VL L N + ++P + S LT
Sbjct: 175 EILYLGQNCYYRNPCYVSYSIEK--DAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTE--- 229
Query: 531 LSLNSNRLTVLSHNDLP--ANLEILDISRN 558
L L +N + + +D L+ILD+S N
Sbjct: 230 LYLYNNMIAKIQEDDFNNLNQLQILDLSGN 259
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 179 bits (455), Expect = 7e-45
Identities = 226/865 (26%), Positives = 368/865 (42%), Gaps = 101/865 (11%)
Query: 35 FCNLTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQY------------ 81
F +L+ VP L ++ +L LS I+ ++ F L L LL+L
Sbjct: 210 FNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVP 269
Query: 82 ----TPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLK 137
+ ID+ AF+NL LR L+L S+ + ++ F+ + HL L L F L +
Sbjct: 270 CDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIAS 329
Query: 138 DGYFRNLKALTRLDLSKNQIRSLY-----LHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192
+ L L LDLS N I+ Y + +F KL SL+++ + E + +P
Sbjct: 330 GAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQP 389
Query: 193 L-QGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAIS 251
L Q LS +L N + +D+ K F N LEI+ +S N + + + + +
Sbjct: 390 LMQLPNLSTINLGINFI---KQIDF-KLFQNFSN--LEIIYLSENRIS-PLVKDTRQSYA 442
Query: 252 KSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETL 311
S +F + F F DP N F R ++ ++G
Sbjct: 443 NSSSFQRHIRKR-RSTDFEF----DPHSN-FYHFTRPLIKPQCAAYG------------- 483
Query: 312 KDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYS-SNFYGLPKVAYIDLQKN 370
K L+L+ N I I F L ++ LNLS N ++ S + F +P V Y+DL N
Sbjct: 484 ---KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN 540
Query: 371 HIAIIQDQTFKFLEKLQTLDLRDNA-----------LTTIHFIPSIPDIFLSGNKLVTL- 418
+ L L+ LDL N+ L I ++ + LS N + TL
Sbjct: 541 RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT 600
Query: 419 PKINL-TANLIHL--SENRLENL----DILYFLL--RVPHLQILILNQNRFSSCSGDQTP 469
K NL + +L+ L S NRL+ L D Y + + +L L L+ NR +
Sbjct: 601 DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL 660
Query: 470 SENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALR 529
+ SL +L + +NML+ W + + L++L L N L L + ++LR
Sbjct: 661 NLPASLTELHINDNMLKF-----FNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLR 715
Query: 530 GLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVF-----VSLSVLDITHNKFI 582
L L+ NR++ L L ++L+ LD+S N L N LS+L++ N F
Sbjct: 716 TLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFE 775
Query: 583 CECELSTFINWLN-HTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFS 641
C C++ F W++ H NV I D+ C P G S+ SL C + L F
Sbjct: 776 CTCDIGDFRRWMDEHLNVKIP-RLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFF 834
Query: 642 LFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSS 701
F + T+ ++ L F + Y V T YDAY+ + +
Sbjct: 835 TFFI----TTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTF--YDAYISYDT 888
Query: 702 KDFT---WVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLV 758
KD + WV N L HL+ + D+N LC EERD+ PG I N+ +I S+K V ++
Sbjct: 889 KDASVTDWVINELRYHLE-ESRDKNVL-LCLEERDWDPGLAIIDNLMQSINQSKKTVFVL 946
Query: 759 SRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRW 818
++ + + AF A R + + +I +++ + Q+ ++ +R + K L+W
Sbjct: 947 TKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHS--QYLRLRQRICKSSILQW 1004
Query: 819 PEDLQDVGWFLHKLSQQILKKEKEK 843
P++ + G F L +L + +
Sbjct: 1005 PDNPKAEGLFWQTLRNVVLTENDSR 1029
Score = 70.9 bits (172), Expect = 5e-12
Identities = 136/538 (25%), Positives = 219/538 (40%), Gaps = 99/538 (18%)
Query: 100 LDLGSSKIYFLHPDAFQGLFHLFELRLYFC----------GLSDAVLK--DGYFRNLKAL 147
LDL + I + ++FQGL +L ++ L G+ L DG F NLK L
Sbjct: 68 LDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNL 127
Query: 148 TRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANS 207
L L NQ+ + PS G SL + N I+ + + + L L LA N
Sbjct: 128 RELLLEDNQLPQI---PS-GLPESLTELSLIQNNIYNITKEGISRL--INLKNLYLAWNC 181
Query: 208 LYSRVSVDWGKCMNPFRNMV-LEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMG 266
+++V F + LE+L +S N + + +++ K L L++
Sbjct: 182 YFNKVCEKTNIEDGVFETLTNLELLSLSFNSLS-HVPPKLPSSLRK-----LFLSN---- 231
Query: 267 AGFGFHNIKDPDQNTFAGLARSSVRHLDLS-----------------HGFVFSLNSRVFE 309
IK + F GL ++ LDLS G +++ F+
Sbjct: 232 -----TQIKYISEEDFKGLINLTL--LDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQ 284
Query: 310 TLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYN-LLGELYSSNFYG-LPKVAYIDL 367
L L+ LNL+ + KI F + +L+VL+L +N L+GE+ S F LP++ +DL
Sbjct: 285 NLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDL 344
Query: 368 QKNHIA------IIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKI 421
N+I I + F L L+ L LR + D F +L L I
Sbjct: 345 SFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELR-----EDDFQPLMQLPNLSTI 399
Query: 422 NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPS-ENPSLEQLFL 480
NL N I + +D F +L+I+ L++NR S D S N S Q +
Sbjct: 400 NLGINFI-------KQIDFKLF-QNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHI 451
Query: 481 GENMLQLAWETELCWDVFEGLSHL-------------QVLYLNHNYLNSLPPGVFSHLTA 527
+ T+ +D H + L L+ N + + P F +L
Sbjct: 452 RKRR-----STDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPD 506
Query: 528 LRGLSLNSN-RLTVLSHNDLPA--NLEILDISRNQLLAPNPDVFVSLS---VLDITHN 579
+ L+L++N VLS + A +++ LD++ N+L N LS VLD+++N
Sbjct: 507 IACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 564
Score = 48.1 bits (113), Expect = 3e-05
Identities = 78/371 (21%), Positives = 134/371 (36%), Gaps = 61/371 (16%)
Query: 26 FDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLT 85
FD FY F PQ + L LS N I + + F L + L L +
Sbjct: 461 FDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQV 520
Query: 86 IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLK 145
+ F +P+++ LDL ++++ F + A L L L L + YFR
Sbjct: 521 LSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSY--------NSHYFRIAG 572
Query: 146 ALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAA 205
L+ +N +LK ++ S N I+ + + L+ K+L +
Sbjct: 573 VTHHLEFIQN-------------FTNLKVLNLSHNNIYTLTDK--YNLESKSLVELVFSG 617
Query: 206 NSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIM 265
N R+ + W N N + I N +D++ N
Sbjct: 618 N----RLDILW----NDDDNRYISIFKGLKNLTRLDLSLN-------------------- 649
Query: 266 GAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKIN 325
+K F L +S+ L ++ + N + + L++L+L NK+
Sbjct: 650 -------RLKHIPNEAFLNLP-ASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLL 701
Query: 326 KIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTF--KFL 383
+ D +L+ L LS+N + L S + + ++DL N + I K
Sbjct: 702 FLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTT 761
Query: 384 EKLQTLDLRDN 394
KL L+L N
Sbjct: 762 TKLSMLELHGN 772
Score = 45.1 bits (105), Expect = 3e-04
Identities = 87/329 (26%), Positives = 130/329 (39%), Gaps = 92/329 (27%)
Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN------------KIN--KIADEAFYGL 335
V LDLS F+ + + F+ L++L +NL +N + N I D AF L
Sbjct: 65 VTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNL 124
Query: 336 DNLQVLNLSYNLLGE-------------LYSSNFYGLPKVA---YIDLQKNHIA------ 373
NL+ L L N L + L +N Y + K I+L+ ++A
Sbjct: 125 KNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFN 184
Query: 374 ------IIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD----IFLSGNKLVTLPK--- 420
I+D F+ L L+ L L N+L+ H P +P +FLS ++ + +
Sbjct: 185 KVCEKTNIEDGVFETLTNLELLSLSFNSLS--HVPPKLPSSLRKLFLSNTQIKYISEEDF 242
Query: 421 ---INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQ 477
INLT L+ LS N + + VP +N +RF+ + Q N S
Sbjct: 243 KGLINLT--LLDLSGNCPRCFNAPFPC--VPCDGGASINIDRFAFQNLTQLRYLNLSSTS 298
Query: 478 LFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYL-NSLPPGVFSHLTALRGLSLNSN 536
L + AW F+ + HL+VL L NYL + G F
Sbjct: 299 L----RKINAAW--------FKNMPHLKVLDLEFNYLVGEIASGAF-------------- 332
Query: 537 RLTVLSHNDLPANLEILDISRNQLLAPNP 565
LT+L LEILD+S N + P
Sbjct: 333 -LTML------PRLEILDLSFNYIKGSYP 354
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 167 bits (424), Expect = 3e-41
Identities = 202/831 (24%), Positives = 358/831 (43%), Gaps = 88/831 (10%)
Query: 37 NLTQVPQVLN-TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLP 95
N ++P L +T+ L LSFN +R + + SF +LQ+L+L S+ TI+ A+++L
Sbjct: 44 NFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDL-SRCEIQTIEDGAYQSLS 102
Query: 96 NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN 155
+L L L + I L AF GL L +L L A L++ +LK L L+++ N
Sbjct: 103 HLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNL--ASLENFPIGHLKTLKELNVAHN 160
Query: 156 QIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVD 215
I+S L F L +L+ +D SSN+I + +L L L SL SL +
Sbjct: 161 LIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDL-SLNPMNFIQ 219
Query: 216 WGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIK 275
G F+ + L L + N ++++ ++ + L+L G N++
Sbjct: 220 PGA----FKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVL-----GEFRNEGNLE 270
Query: 276 DPDQNTFAGLARSSVRHLDLSH-GFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAF-Y 333
D++ GL ++ L++ + +F L ++ +L I ++ D ++ +
Sbjct: 271 KFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNF 330
Query: 334 GLDNLQVLNLSYNLLGEL---------YSSNFYG-------LPKVAYIDLQKNHIAI--I 375
G +L+++N + L ++SN G LP + ++DL +N ++
Sbjct: 331 GWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGC 390
Query: 376 QDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENR- 434
Q+ L+ LDL N + T+ FL +L L + +NL +SE
Sbjct: 391 CSQSDFGTTSLKYLDLSFNGVITMS------SNFLGLEQLEHLDFQH--SNLKQMSEFSV 442
Query: 435 -LENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETEL 493
L +++Y L + H + F+ S SLE L + N Q
Sbjct: 443 FLSLRNLIY--LDISHTHTRVAFNGIFNGLS---------SLEVLKMAGNSFQ----ENF 487
Query: 494 CWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLE 551
D+F L +L L L+ L L P F+ L++L+ L+++ N L +L+
Sbjct: 488 LPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQ 547
Query: 552 ILDISRNQLLAPNPDVFV----SLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPAD 607
+LD S N ++ SL+ L++T N F C CE +F+ W+ +
Sbjct: 548 VLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVER- 606
Query: 608 IYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFC 667
+ C P G+ + SL+ I C + T+ +++L+V
Sbjct: 607 MECATPSDKQGMPVLSLN------------------ITCQMNKTIIGVSVLSVLVVSVVA 648
Query: 668 FICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNL 727
+ YK L+ YDA++ +SS+D WV+N L+K+L+ F L
Sbjct: 649 VLVYKFYFHLMLLAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPP---FQL 705
Query: 728 CFEERDFVPGENRIANI-QDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSA 786
C RDF+PG ANI + SRK++ +VS+HF++ WC+ + AQ +
Sbjct: 706 CLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAG 765
Query: 787 LIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQIL 837
+I +V+ + + L + + + + YL W + + F +L + +L
Sbjct: 766 IIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALL 816
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 152 bits (385), Expect = 1e-36
Identities = 199/829 (24%), Positives = 339/829 (40%), Gaps = 82/829 (9%)
Query: 34 RFCNLTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQ-----YTPLT-- 85
++ NLT VP+ L ++ E LLLS+N I + L L++L++G + P
Sbjct: 207 KYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCM 266
Query: 86 --------IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLK 137
+ + F +L L L L S + +L+ F+GL +L L L L + K
Sbjct: 267 ECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITK 326
Query: 138 DGYFRNLKALTRLDLSKN-----QIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192
F+ L L +L+LS N L L PSFG L +LK +D + E L P
Sbjct: 327 TKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRP 386
Query: 193 LQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISK 252
L + + ++ + + R + L +SG ++T A
Sbjct: 387 LARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGAS---ELTATMGEADGG 443
Query: 253 SQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLK 312
+ + + + P F + LDLS + ++ +F L
Sbjct: 444 EKVW-------LQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLS 496
Query: 313 DLKVLNLAYNKINKIADEA-FYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNH 371
L+ L L++N I++ + + F L LQVL+LS+N L + +F LP++ +DL N
Sbjct: 497 HLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNS 556
Query: 372 IAIIQD---QTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLI 428
F F+ L+TL A IH V+ + + +
Sbjct: 557 QPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIH-------------SQVSQQLCSTSLRAL 603
Query: 429 HLSENRLENL----DI-LYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGEN 483
S N L ++ D+ L+F + L L L+QNR + + SL+ L L +N
Sbjct: 604 DFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDN 663
Query: 484 MLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSH 543
L W L L+VL L N L +L G T LR L ++ N ++ ++
Sbjct: 664 YLAF-----FKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAP 718
Query: 544 NDLPANLEI--LDISRNQLLAPNPDVF----VSLSVLDITHNKFICECELSTFINWLNHT 597
E+ L++S N L + F +L +LD++ N C C + F+++L
Sbjct: 719 GFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACG-AAFMDFLLEV 777
Query: 598 NVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTI 657
+ G P+ + C P G+S+F+ C +E +L + F + + + L L
Sbjct: 778 QAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDE----ALSWDCFALSLLAVALGLGVP 833
Query: 658 LTVTKFRGFCFICYKTAQR-LVFKDHPQGTEPDMYKYDAYLCFSSKDFT---WVQNALLK 713
+ + C+ L ++ G + D YDA++ F WV N L
Sbjct: 834 MLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRG 893
Query: 714 HLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFS 773
L+ + + LC EERD++PG+ N+ +++ SRK + +++ G +F
Sbjct: 894 QLE-ECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFL 952
Query: 774 YAQGRCLSDLNSALIMVVV---GSLSQYQLMKHQSIRGFVQKQQYLRWP 819
AQ R L D +++V++ G S+Y ++ + R Q L WP
Sbjct: 953 LAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCR-----QSVLLWP 996
Score = 43.9 bits (102), Expect = 6e-04
Identities = 68/279 (24%), Positives = 108/279 (38%), Gaps = 79/279 (28%)
Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNA----LTTIHF-------------IPS 404
V + L N I + D F L L+ L+L+ N L+ +HF +P+
Sbjct: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPT 124
Query: 405 IPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCS 464
+ ++ LS N ++T+P L +LI LS + H IL+L+ +
Sbjct: 125 LEELNLSYNNIMTVPA--LPKSLISLS---------------LSHTNILMLDSASLAGLH 167
Query: 465 GDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSH 524
+L LF+ N + C E + PG
Sbjct: 168 ---------ALRFLFMDGN----CYYKNPCRQALE-----------------VAPGALLG 197
Query: 525 LTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLS---VLDITHNKF 581
L L LSL N LTV+ N LP++LE L +S N+++ P+ +L+ VLD+ N
Sbjct: 198 LGNLTHLSLKYNNLTVVPRN-LPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCR 256
Query: 582 ICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVS 620
C+ H P ++PD+FS +S
Sbjct: 257 RCD-----------HAPNPCMECPRHFPQLHPDTFSHLS 284
Score = 40.4 bits (93), Expect = 0.007
Identities = 81/312 (25%), Positives = 121/312 (38%), Gaps = 42/312 (13%)
Query: 245 NFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV---- 300
+FS A + SL L+ + + H++ D D FA L S+RHL+L
Sbjct: 55 HFSMAAPRGNVTSLSLSSNRI------HHLHDSD---FAHLP--SLRHLNLKWNCPPVGL 103
Query: 301 --------FSLNSRVFETLKDLKVLNLAYNKINKIA----DEAFYGLDNLQVLNLSYNLL 348
++ F + L+ LNL+YN I + L + +L L L
Sbjct: 104 SPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASL 163
Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI--HFIPSIP 406
L++ F + Y + L L L L+ N LT + + S+
Sbjct: 164 AGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLE 223
Query: 407 DIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGD 466
+ LS N++V L +L ANL L LD+ R H + R
Sbjct: 224 YLLLSYNRIVKLAPEDL-ANL-----TALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHP 277
Query: 467 QTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNS--LPPGVFSH 524
T S LE L L ++ L+W W F GL +L+VL L+ N+L F
Sbjct: 278 DTFSHLSRLEGLVLKDS--SLSW-LNASW--FRGLGNLRVLDLSENFLYKCITKTKAFQG 332
Query: 525 LTALRGLSLNSN 536
LT LR L+L+ N
Sbjct: 333 LTQLRKLNLSFN 344
>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 140 bits (352), Expect = 7e-33
Identities = 172/750 (22%), Positives = 302/750 (40%), Gaps = 108/750 (14%)
Query: 165 SFGKLNSLKSIDF---SSNQIFLVCEHELEPLQGKTLSF------FSLAANSLYSRVSVD 215
S+ L L+S DF S ++ ++C + ++ L KT F L+ N L S V
Sbjct: 56 SYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKS---VT 112
Query: 216 W---------GKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMG 266
W N F M I + +GN ++I G I KS F I H+
Sbjct: 113 WYLLAGLRYLDLSFNDFDTM--PICEEAGNMSHLEILGLSGAKIQKSD-FQKIAHLHLNT 169
Query: 267 AGFGFHNIKD------------------PDQNTFAGLARSSVR--------HLDLSHGFV 300
GF + P F L R ++ ++D FV
Sbjct: 170 VFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFV 229
Query: 301 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFY--------GLDNLQVLNLSYNLLGELY 352
S + +L++ K L NK++ + D+ F +++ Q+ N+++ L
Sbjct: 230 -SYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLD 288
Query: 353 SSNF-YGLPKVAYIDLQKNHIAII---QDQTFKFLEKLQTLDLR-DNALTTIHFIPSIPD 407
++F Y + I L+ H + QD+ + L K+ +L NA P+ P
Sbjct: 289 HNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPT 348
Query: 408 IFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ 467
F ++ + N L + ++ +++PHL+ LILN N+ + S
Sbjct: 349 KF----------------QYLNFANNILTD-ELFKRTIQLPHLKTLILNGNKLETLSLVS 391
Query: 468 TPSENPSLEQLFLGENMLQLAWETELCW----------------DVFEGL-SHLQVLYLN 510
+ N LE L L +N+LQ + W VF L +Q+L LN
Sbjct: 392 CFANNTPLEHLDLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLN 451
Query: 511 HNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVS 570
+N + ++P HL ALR L++ N LT L + L +L+I N +L+P+ D S
Sbjct: 452 NNQIQTVPKETI-HLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQS 510
Query: 571 ---LSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTE 627
+ L+ N F C CEL FI ++ V + G C YP + G L +
Sbjct: 511 CQEVKTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLH 570
Query: 628 GCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTE 687
L + + ++ F + + C +T R+ + Q
Sbjct: 571 ELSCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRV--RKTTQEQL 628
Query: 688 PDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDA 747
++ A++ +S D WV+N L+ +L+ + +C E F PG++ NI
Sbjct: 629 KRNVRFHAFISYSEHDSLWVKNELIPNLE---KEDGSILICLYESYFDPGKSISENIVSF 685
Query: 748 IWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQL-MKHQSI 806
I S K + ++S +F+++ WC F +A + + +I++++ + Y + ++ +
Sbjct: 686 IEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKL 745
Query: 807 RGFVQKQQYLRWPEDLQDVGWFLHKLSQQI 836
+ ++K+ YL WP+D + G F L I
Sbjct: 746 KALLEKKAYLEWPKDRRKCGLFWANLRAAI 775
Score = 52.8 bits (125), Expect = 1e-06
Identities = 32/92 (34%), Positives = 54/92 (58%), Gaps = 2/92 (2%)
Query: 341 LNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI- 399
L+LSYNLL +L SS+F+ + K+ + L N I + +TF+F ++L+ LDL +N L ++
Sbjct: 53 LDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVT 112
Query: 400 -HFIPSIPDIFLSGNKLVTLPKINLTANLIHL 430
+ + + + LS N T+P N+ HL
Sbjct: 113 WYLLAGLRYLDLSFNDFDTMPICEEAGNMSHL 144
Score = 43.1 bits (100), Expect = 0.001
Identities = 28/78 (35%), Positives = 43/78 (55%), Gaps = 3/78 (3%)
Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352
LDLS+ +F L S F ++ L+VL L +N+I ++ + F L+ L+LS N L
Sbjct: 53 LDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNN---RLK 109
Query: 353 SSNFYGLPKVAYIDLQKN 370
S +Y L + Y+DL N
Sbjct: 110 SVTWYLLAGLRYLDLSFN 127
>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 140 bits (352), Expect = 7e-33
Identities = 172/750 (22%), Positives = 302/750 (40%), Gaps = 108/750 (14%)
Query: 165 SFGKLNSLKSIDF---SSNQIFLVCEHELEPLQGKTLSF------FSLAANSLYSRVSVD 215
S+ L L+S DF S ++ ++C + ++ L KT F L+ N L S V
Sbjct: 56 SYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKS---VT 112
Query: 216 W---------GKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMG 266
W N F M I + +GN ++I G I KS F I H+
Sbjct: 113 WYLLAGLRYLDLSFNDFDTM--PICEEAGNMSHLEILGLSGAKIQKSD-FQKIAHLHLNT 169
Query: 267 AGFGFHNIKD------------------PDQNTFAGLARSSVR--------HLDLSHGFV 300
GF + P F L R ++ ++D FV
Sbjct: 170 VFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFV 229
Query: 301 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFY--------GLDNLQVLNLSYNLLGELY 352
S + +L++ K L NK++ + D+ F +++ Q+ N+++ L
Sbjct: 230 -SYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLD 288
Query: 353 SSNF-YGLPKVAYIDLQKNHIAII---QDQTFKFLEKLQTLDLR-DNALTTIHFIPSIPD 407
++F Y + I L+ H + QD+ + L K+ +L NA P+ P
Sbjct: 289 HNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPT 348
Query: 408 IFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ 467
F ++ + N L + ++ +++PHL+ LILN N+ + S
Sbjct: 349 KF----------------QYLNFANNILTD-ELFKRTIQLPHLKTLILNGNKLETLSLVS 391
Query: 468 TPSENPSLEQLFLGENMLQLAWETELCW----------------DVFEGL-SHLQVLYLN 510
+ N LE L L +N+LQ + W VF L +Q+L LN
Sbjct: 392 CFANNTPLEHLDLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLN 451
Query: 511 HNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVS 570
+N + ++P HL ALR L++ N LT L + L +L+I N +L+P+ D S
Sbjct: 452 NNQIQTVPKETI-HLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQS 510
Query: 571 ---LSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTE 627
+ L+ N F C CEL FI ++ V + G C YP + G L +
Sbjct: 511 CQEVKTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLH 570
Query: 628 GCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTE 687
L + + ++ F + + C +T R+ + Q
Sbjct: 571 ELSCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRV--RKTTQEQL 628
Query: 688 PDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDA 747
++ A++ +S D WV+N L+ +L+ + +C E F PG++ NI
Sbjct: 629 KRNVRFHAFISYSEHDSLWVKNELIPNLE---KEDGSILICLYESYFDPGKSISENIVSF 685
Query: 748 IWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQL-MKHQSI 806
I S K + ++S +F+++ WC F +A + + +I++++ + Y + ++ +
Sbjct: 686 IEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKL 745
Query: 807 RGFVQKQQYLRWPEDLQDVGWFLHKLSQQI 836
+ ++K+ YL WP+D + G F L I
Sbjct: 746 KALLEKKAYLEWPKDRRKCGLFWANLRAAI 775
Score = 52.8 bits (125), Expect = 1e-06
Identities = 32/92 (34%), Positives = 54/92 (58%), Gaps = 2/92 (2%)
Query: 341 LNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI- 399
L+LSYNLL +L SS+F+ + K+ + L N I + +TF+F ++L+ LDL +N L ++
Sbjct: 53 LDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVT 112
Query: 400 -HFIPSIPDIFLSGNKLVTLPKINLTANLIHL 430
+ + + + LS N T+P N+ HL
Sbjct: 113 WYLLAGLRYLDLSFNDFDTMPICEEAGNMSHL 144
Score = 43.1 bits (100), Expect = 0.001
Identities = 28/78 (35%), Positives = 43/78 (55%), Gaps = 3/78 (3%)
Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352
LDLS+ +F L S F ++ L+VL L +N+I ++ + F L+ L+LS N L
Sbjct: 53 LDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNN---RLK 109
Query: 353 SSNFYGLPKVAYIDLQKN 370
S +Y L + Y+DL N
Sbjct: 110 SVTWYLLAGLRYLDLSFN 127
>gi|19718734 toll-like receptor 2 [Homo sapiens]
Length = 784
Score = 132 bits (331), Expect = 2e-30
Identities = 188/767 (24%), Positives = 312/767 (40%), Gaps = 117/767 (15%)
Query: 96 NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN 155
NL+ L L S+ I + D+F L L L L + LS+ L +F+ L +LT L+L N
Sbjct: 77 NLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSN--LSSSWFKPLSSLTFLNLLGN 134
Query: 156 QIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHE-------LEPLQGKTLSFFSLAANSL 208
++L F L L+ + + F + + LE L+ S SL
Sbjct: 135 PYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSL 194
Query: 209 YSRVSVDWGKCMNPFRNMVLEI-LDVSGNGWTVDI------TGNFSNAISKSQAFSLILA 261
S +V ++LEI +DV+ + +++ T +FS +S + SLI
Sbjct: 195 KSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSE-LSTGETNSLIKK 253
Query: 262 HHIMGAGFGFHNIKDPDQNTF---------AGLARSSVRHLDLSH--GFVFSLNSRVFET 310
F F N+K D++ F +GL L+ F S N RV +
Sbjct: 254 -------FTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDP 306
Query: 311 LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370
K V L +++ FY L L L +V I ++ +
Sbjct: 307 GK---VETLTIRRLHIPRFYLFYDLSTLYSLT-----------------ERVKRITVENS 346
Query: 371 HIAIIQDQTFKFLEKLQTLDLRDNALTTIHFI--------PSIPDIFLSGNKLVTLPKIN 422
+ ++ + L+ L+ LDL +N + + PS+ + L N L +L K
Sbjct: 347 KVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTG 406
Query: 423 LTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGE 482
T L+ L N+DI ++N F S E E
Sbjct: 407 ETL----LTLKNLTNIDI---------------SKNSFHSMP-----------ETCQWPE 436
Query: 483 NMLQLAWETELCWDVFEGLSH-LQVLYLNHNYLNSLPPGVFS-HLTALRGLSLNSNRLTV 540
M L + V + L++L +++N LN +FS +L L+ L ++ N+L
Sbjct: 437 KMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLN-----LFSLNLPQLKELYISRNKLMT 491
Query: 541 LSHNDLPANLEILDISRNQLLAPNP---DVFVSLSVLDITHNKFICECELSTFINWLNHT 597
L L L +L ISRN + + D F +L L+ N FIC CE +F
Sbjct: 492 LPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQAL 551
Query: 598 NVTIAGPPADIYCVYPDSFSG--VSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLM 655
+ PA+ C P G V LS C ++ + +LF+ L L+
Sbjct: 552 AKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL-------LILL 604
Query: 656 TILTVTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHL 715
T + +F G ++ A L K P+ YDA++ +S +D WV+N +++ L
Sbjct: 605 TGVLCHRFHGLWYMKMMWAW-LQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQEL 663
Query: 716 DTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYA 775
+ + F LC +RDF+PG+ I NI D+I S K V ++S +F++ WC ++
Sbjct: 664 E---NFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS 720
Query: 776 QGRCLSDLNSALIMVVVGSLSQYQL-MKHQSIRGFVQKQQYLRWPED 821
R + N A I++++ + + + + +R + + YL WP D
Sbjct: 721 HFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMD 767
Score = 46.6 bits (109), Expect = 1e-04
Identities = 46/189 (24%), Positives = 85/189 (44%), Gaps = 31/189 (16%)
Query: 239 TVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHG 298
++D++ N IS S + ++ G + I ++++F+ L S+ HLDLS+
Sbjct: 56 SLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTI---EEDSFSSLG--SLEHLDLSYN 110
Query: 299 FVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYG-LDNLQVLNL-SYNLLGELYSSNF 356
++ +L+S F+ L L LNL N + + + + L LQ+L + + + ++ +F
Sbjct: 111 YLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDF 170
Query: 357 YGLP-----KVAYIDLQK------------NHIAIIQDQTFKFLE-------KLQTLDLR 392
GL ++ DLQ +H+ + Q LE ++ L+LR
Sbjct: 171 AGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELR 230
Query: 393 DNALTTIHF 401
D L T HF
Sbjct: 231 DTDLDTFHF 239
Score = 43.9 bits (102), Expect = 6e-04
Identities = 29/98 (29%), Positives = 49/98 (50%)
Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPK 361
SLNS + +K L+L+ N+I I++ NLQ L L+ N + + +F L
Sbjct: 42 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 101
Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI 399
+ ++DL N+++ + FK L L L+L N T+
Sbjct: 102 LEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTL 139
Score = 37.7 bits (86), Expect = 0.046
Identities = 30/97 (30%), Positives = 52/97 (53%), Gaps = 9/97 (9%)
Query: 514 LNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVFVSL 571
LNS+P G+ A++ L L++NR+T +S++DL NL+ L ++ N + D F SL
Sbjct: 43 LNSIPSGLTE---AVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSL 99
Query: 572 SV---LDITHNKFICECELSTFINWLNHTNVTIAGPP 605
LD+++N ++ S F + T + + G P
Sbjct: 100 GSLEHLDLSYN-YLSNLSSSWFKPLSSLTFLNLLGNP 135
>gi|20143971 toll-like receptor 6 [Homo sapiens]
Length = 796
Score = 130 bits (326), Expect = 7e-30
Identities = 190/818 (23%), Positives = 350/818 (42%), Gaps = 114/818 (13%)
Query: 38 LTQVPQVLNTTERLL-LSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPN 96
L VP+ L ++L +S NYI + S FL +L +L L L +D F+ +
Sbjct: 43 LIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQL-LDLSVFKFNQD 101
Query: 97 LRILDLGSSKIYFL--HPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSK 154
L LDL +++ + HP + + LDLS
Sbjct: 102 LEYLDLSHNQLQKISCHP-------------------------------IVSFRHLDLSF 130
Query: 155 NQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSV 214
N ++L + FG L+ L + S+ ++ + +L P+ LS+ L + Y + +
Sbjct: 131 NDFKALPICKEFGNLSQLNFLGLSAMKLQKL---DLLPIAHLHLSYILLDLRNYYIKEN- 186
Query: 215 DWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNI 274
L+IL+ T F A + ++ + +G NI
Sbjct: 187 ---------ETESLQILNAKTLHLVFHPTSLF--------AIQVNISVNTLGC-LQLTNI 228
Query: 275 KDPDQNT------FAGLAR-SSVRHLDLSH-GFVFSLNSRVFETL--KDLKVLNLAYNK- 323
K D N + L R S++ + L+H + RVF+ L K ++ LN+ YN
Sbjct: 229 KLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNI-YNLT 287
Query: 324 -INKIADEAF-YGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFK 381
I I +E F Y L+ L + + + + F Y + +I ++
Sbjct: 288 IIESIREEDFTYSKTTLKALTIEH-----ITNQVFLFSQTALYTVFSEMNIMMLTISDTP 342
Query: 382 FLEKLQTLDLRDNALTTIHFIPSIPDIFLSG--NKLVTLPKINLTANLIHLSENRLENLD 439
F+ L +A +T F+ ++F K TL K+ + L +N L++L
Sbjct: 343 FIHMLCP-----HAPSTFKFLNFTQNVFTDSIFEKCSTLVKLET----LILQKNGLKDLF 393
Query: 440 ILYFLLR-VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVF 498
+ + + +P L+IL ++ N S + + S+ L L NML + VF
Sbjct: 394 KVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDS--------VF 445
Query: 499 EGLS-HLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISR 557
L ++VL L+ N + S+P V L AL+ L++ N LT L ++L +L I
Sbjct: 446 RCLPPRIKVLDLHSNKIKSVPKQVVK-LEALQELNVAFNSLTDLPGCGSFSSLSVLIIDH 504
Query: 558 NQLLAPNPDVFVS---LSVLDITHNKFICECELSTFINWLNH-TNVTIAGPPADIYCVYP 613
N + P+ D F S + + N F C CEL F+ ++ ++ + G P C YP
Sbjct: 505 NSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYKCDYP 564
Query: 614 DSFSGVSL--FSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICY 671
+S+ G L F +S C+ ++ ++ ++ +V VT+T + + R +C
Sbjct: 565 ESYRGSPLKDFHMSELSCNITLLIVTIGATM-LVLAVTVTSLCIYLDLPWYLR---MVCQ 620
Query: 672 KTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEE 731
T R ++ P ++ A++ +S D WV++ L+ +L+ + +C E
Sbjct: 621 WTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKE-----DIQICLHE 675
Query: 732 RDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVV 791
R+FVPG++ + NI + I S K + ++S +F++ WC +A + ++ LI+++
Sbjct: 676 RNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILIL 735
Query: 792 VGSLSQYQL-MKHQSIRGFVQKQQYLRWPEDLQDVGWF 828
+ + Q + K+ ++ + ++ YL+WP++ G F
Sbjct: 736 LEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLF 773
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 125 bits (314), Expect = 2e-28
Identities = 118/476 (24%), Positives = 216/476 (45%), Gaps = 51/476 (10%)
Query: 404 SIPDIFLSGNKLVTLPKINLTANLIHLS-ENRLENLDILYFLLRVPHLQILILNQNRFSS 462
+I + +SG ++V + + + +HL N L + + L+ LIL N+
Sbjct: 327 NIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKE 386
Query: 463 CSG-DQTPSENPSLEQLFLGEN----------------MLQLAWETELCWD-VFEGLS-H 503
S + ++ SL+QL + +N +L L + + D +F L
Sbjct: 387 LSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPR 446
Query: 504 LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAP 563
++VL L+ N + S+P V L AL+ L++ N LT L ++L +L I N + P
Sbjct: 447 IKVLDLHSNKIKSIPKQVVK-LEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHP 505
Query: 564 NPDVFVS---LSVLDITHNKFICECELSTFINWLNH-TNVTIAGPPADIYCVYPDSFSGV 619
+ D F S + + N F C CEL F+ ++ ++ + G P C YP+S+ G
Sbjct: 506 SADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGT 565
Query: 620 SL--FSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFC-------FIC 670
L F +S C+ +L IV T+ T+ ++ + TVT + +C
Sbjct: 566 LLKDFHMSELSCN---------ITLLIV-TIVATMLVLAV-TVTSLCSYLDLPWYLRMVC 614
Query: 671 YKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFE 730
T R ++ P ++ A++ +S D WV+N LL +L+ + +C
Sbjct: 615 QWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKE-----GMQICLH 669
Query: 731 ERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMV 790
ER+FVPG++ + NI I S K + ++S +F++ WC +A + +++LI++
Sbjct: 670 ERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILI 729
Query: 791 VVGSLSQYQL-MKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKEKEKKK 845
++ + QY + + ++ + ++ YL WP++ G F L I K E+ K
Sbjct: 730 LLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAK 785
Score = 47.8 bits (112), Expect = 4e-05
Identities = 36/120 (30%), Positives = 56/120 (46%), Gaps = 11/120 (9%)
Query: 340 VLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI 399
+LN+S N + EL++S+ L K+ + + N I + FKF ++L+ LDL N L I
Sbjct: 49 ILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI 108
Query: 400 HFIPSI--PDIFLSGNKLVTLPKINLTANL-----IHLSENRLENLDILYFLLRVPHLQI 452
P++ + LS N LP N+ + LS LE + L + HL I
Sbjct: 109 SCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSV----LPIAHLNI 164
Score = 38.1 bits (87), Expect = 0.035
Identities = 33/108 (30%), Positives = 55/108 (50%), Gaps = 11/108 (10%)
Query: 485 LQLAWETELCWDVFE-GLSHLQ--------VLYLNHNYLNSLPPGVFSHLTALRGLSLNS 535
+QL+ E+E D + GL H+ +L ++ NY++ L L+ LR L ++
Sbjct: 19 IQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISH 78
Query: 536 NRLTVLSHNDLPAN--LEILDISRNQLLAPNPDVFVSLSVLDITHNKF 581
NR+ L + N LE LD+S N+L+ + V+L LD++ N F
Sbjct: 79 NRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAF 126
Score = 37.7 bits (86), Expect = 0.046
Identities = 26/89 (29%), Positives = 50/89 (56%), Gaps = 4/89 (4%)
Query: 285 LARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLS 344
L+ S +R L +SH + L+ VF+ ++L+ L+L++NK+ KI + + NL+ L+LS
Sbjct: 66 LSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI---SCHPTVNLKHLDLS 122
Query: 345 YNLLGEL-YSSNFYGLPKVAYIDLQKNHI 372
+N L F + ++ ++ L H+
Sbjct: 123 FNAFDALPICKEFGNMSQLKFLGLSTTHL 151
Score = 35.0 bits (79), Expect = 0.30
Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 6/81 (7%)
Query: 478 LFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNR 537
L + +N + W +++ LS L++L ++HN + L VF L L L+ N+
Sbjct: 50 LNISQNYISELWTSDIL-----SLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNK 104
Query: 538 LTVLSHNDLPANLEILDISRN 558
L +S + NL+ LD+S N
Sbjct: 105 LVKISCHP-TVNLKHLDLSFN 124
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 110 bits (276), Expect = 4e-24
Identities = 143/495 (28%), Positives = 213/495 (43%), Gaps = 67/495 (13%)
Query: 85 TIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNL 144
++ AF+NL +L L+L ++ L P A GL +L L L L L G F +
Sbjct: 126 SVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLAL--GTFAHT 183
Query: 145 KALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLA 204
AL L LS N++ L F L SL ++ N + ++ + L +L LA
Sbjct: 184 PALASLGLSNNRLSRLE-DGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLG--SLRELVLA 240
Query: 205 ANSL-YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSL---IL 260
N L Y + ++ G L LD+S N I N + + Q L ++
Sbjct: 241 GNRLAYLQPALFSGLAE-------LRELDLSRNALRA-IKANVFVQLPRLQKLYLDRNLI 292
Query: 261 AHHIMGAGFGFHNIK--DPDQNTFAGLARSS------VRHLDLSHGFVFSLNSRVFETLK 312
A GA G ++ D N AGL + +R L LSH + SL R F+ L
Sbjct: 293 AAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLH 352
Query: 313 DLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 372
L+ L L +N+I ++A+ +F GL L+VL L +N L E+ + F GL VA ++L N +
Sbjct: 353 FLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412
Query: 373 AIIQDQTFKFLEKLQTLDLRDNAL-----TTIHFIPSIPDIFLSGNKLVTLPKINL--TA 425
+ +Q F+ L KL +L L + L T + + +FL N LV + + +L A
Sbjct: 413 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 472
Query: 426 NLIH--LSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGEN 483
L+ L+ N+L +L PH L + LE L L N
Sbjct: 473 ELLELDLTSNQLTHL---------PHRLFQGLGK-----------------LEYLLLSRN 506
Query: 484 MLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSH 543
L EL D L L ++HN L +LP + + L LR LSL +N L +
Sbjct: 507 RL-----AELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 561
Query: 544 NDLPANLEILDISRN 558
P LE L + N
Sbjct: 562 Q--PPGLERLWLEGN 574
Score = 90.1 bits (222), Expect = 8e-18
Identities = 96/324 (29%), Positives = 146/324 (45%), Gaps = 25/324 (7%)
Query: 267 AGFGFHNIKDPDQNTF---AGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNK 323
+ GF N++ + A L ++ HL L + SL F L L L+ N+
Sbjct: 136 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 195
Query: 324 INKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFL 383
++++ D F GL +L LNL +N L L + F GL + + L N +A +Q F L
Sbjct: 196 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 255
Query: 384 EKLQTLDLRDNALTTIHF-----IPSIPDIFLSGNKLVTLPK---INLTA-NLIHLSENR 434
+L+ LDL NAL I +P + ++L N + + + L A + LS NR
Sbjct: 256 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 315
Query: 435 LENL--DILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETE 492
+ L D LL L++L L+ N +S +T + LE+L LG N ++ +
Sbjct: 316 VAGLLEDTFPGLLG---LRVLRLSHNAIASLR-PRTFKDLHFLEELQLGHNRIR-----Q 366
Query: 493 LCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP--ANL 550
L FEGL L+VL L+HN L + G F LT + ++L+ N L L L
Sbjct: 367 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 426
Query: 551 EILDISRNQLLAPNPDVFVSLSVL 574
L + + L P F LS L
Sbjct: 427 HSLHLEGSCLGRIRPHTFTGLSGL 450
Score = 89.0 bits (219), Expect = 2e-17
Identities = 81/282 (28%), Positives = 127/282 (45%), Gaps = 18/282 (6%)
Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPK 361
S+ F+ L L LNL ++ + +A GL+NL L+L N L L F P
Sbjct: 126 SVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPA 185
Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI-----HFIPSIPDIFLSGNKLV 416
+A + L N ++ ++D F+ L L L+L N+L + + S+ ++ L+GN+L
Sbjct: 186 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 245
Query: 417 TLPKINLTA----NLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSEN 472
L + + LS N L + F+ ++P LQ L L++N ++ +
Sbjct: 246 YLQPALFSGLAELRELDLSRNALRAIKANVFV-QLPRLQKLYLDRNLIAAVAPGAFLGLK 304
Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 532
+L L L N + L D F GL L+VL L+HN + SL P F L L L
Sbjct: 305 -ALRWLDLSHNRV-----AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQ 358
Query: 533 LNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVFVSLS 572
L NR+ L+ LE+L + NQL F+ L+
Sbjct: 359 LGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400
Score = 70.9 bits (172), Expect = 5e-12
Identities = 90/351 (25%), Positives = 153/351 (43%), Gaps = 10/351 (2%)
Query: 53 LSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHP 112
LS N + + F L L L LG + D AFR L +LR L L +++ +L P
Sbjct: 191 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA-AFRGLGSLRELVLAGNRLAYLQP 249
Query: 113 DAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSL 172
F GL L EL L L +K F L L +L L +N I ++ G L +L
Sbjct: 250 ALFSGLAELRELDLSRNALR--AIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLG-LKAL 306
Query: 173 KSIDFSSNQIFLVCEHELEPLQG-KTLSFFSLAANSLYSRVSVD--WGKCMNPFRNMVLE 229
+ +D S N++ + E L G + L A SL R D + + + N + +
Sbjct: 307 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 366
Query: 230 ILDVSGNGW-TVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARS 288
+ + S G +++ N + + +A + + ++ + +++ + F GL +
Sbjct: 367 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 426
Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
HL+ S + + F L L+ L L N + I +++ +GL L L+L+ N L
Sbjct: 427 HSLHLEGS--CLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 484
Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI 399
L F GL K+ Y+ L +N +A + L++ LD+ N L +
Sbjct: 485 THLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEAL 535
Score = 67.8 bits (164), Expect = 4e-11
Identities = 87/326 (26%), Positives = 139/326 (42%), Gaps = 26/326 (7%)
Query: 53 LSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHP 112
LS N +R + A+ F L +LQ L L + AF L LR LDL +++ L
Sbjct: 263 LSRNALRAIKANVFVQLPRLQKLYLDRNLIA-AVAPGAFLGLKALRWLDLSHNRVAGLLE 321
Query: 113 DAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSL 172
D F GL L LRL + A L+ F++L L L L N+IR L SF L L
Sbjct: 322 DTFPGLLGLRVLRLSHNAI--ASLRPRTFKDLHFLEELQLGHNRIRQL-AERSFEGLGQL 378
Query: 173 KSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILD 232
+ + NQ+ E G L ++A +L G C+ RN+ ++
Sbjct: 379 EVLTLDHNQL-------QEVKAGAFLGLTNVAVMNLS-------GNCL---RNLPEQVFR 421
Query: 233 VSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRH 292
G ++ + G+ I L + G I ++ + GLA +
Sbjct: 422 GLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI---EEQSLWGLAE--LLE 476
Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352
LDL+ + L R+F+ L L+ L L+ N++ ++ +A L L++S+N L L
Sbjct: 477 LDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALP 536
Query: 353 SSNFYGLPKVAYIDLQKNHIAIIQDQ 378
+S L ++ Y+ L+ N + Q
Sbjct: 537 NSLLAPLGRLRYLSLRNNSLRTFTPQ 562
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 110 bits (276), Expect = 4e-24
Identities = 143/495 (28%), Positives = 213/495 (43%), Gaps = 67/495 (13%)
Query: 85 TIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNL 144
++ AF+NL +L L+L ++ L P A GL +L L L L L G F +
Sbjct: 88 SVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLAL--GTFAHT 145
Query: 145 KALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLA 204
AL L LS N++ L F L SL ++ N + ++ + L +L LA
Sbjct: 146 PALASLGLSNNRLSRLE-DGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLG--SLRELVLA 202
Query: 205 ANSL-YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSL---IL 260
N L Y + ++ G L LD+S N I N + + Q L ++
Sbjct: 203 GNRLAYLQPALFSGLAE-------LRELDLSRNALRA-IKANVFVQLPRLQKLYLDRNLI 254
Query: 261 AHHIMGAGFGFHNIK--DPDQNTFAGLARSS------VRHLDLSHGFVFSLNSRVFETLK 312
A GA G ++ D N AGL + +R L LSH + SL R F+ L
Sbjct: 255 AAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLH 314
Query: 313 DLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 372
L+ L L +N+I ++A+ +F GL L+VL L +N L E+ + F GL VA ++L N +
Sbjct: 315 FLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
Query: 373 AIIQDQTFKFLEKLQTLDLRDNAL-----TTIHFIPSIPDIFLSGNKLVTLPKINL--TA 425
+ +Q F+ L KL +L L + L T + + +FL N LV + + +L A
Sbjct: 375 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 434
Query: 426 NLIH--LSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGEN 483
L+ L+ N+L +L PH L + LE L L N
Sbjct: 435 ELLELDLTSNQLTHL---------PHRLFQGLGK-----------------LEYLLLSRN 468
Query: 484 MLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSH 543
L EL D L L ++HN L +LP + + L LR LSL +N L +
Sbjct: 469 RL-----AELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523
Query: 544 NDLPANLEILDISRN 558
P LE L + N
Sbjct: 524 Q--PPGLERLWLEGN 536
Score = 90.1 bits (222), Expect = 8e-18
Identities = 96/324 (29%), Positives = 146/324 (45%), Gaps = 25/324 (7%)
Query: 267 AGFGFHNIKDPDQNTF---AGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNK 323
+ GF N++ + A L ++ HL L + SL F L L L+ N+
Sbjct: 98 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 157
Query: 324 INKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFL 383
++++ D F GL +L LNL +N L L + F GL + + L N +A +Q F L
Sbjct: 158 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 217
Query: 384 EKLQTLDLRDNALTTIHF-----IPSIPDIFLSGNKLVTLPK---INLTA-NLIHLSENR 434
+L+ LDL NAL I +P + ++L N + + + L A + LS NR
Sbjct: 218 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 277
Query: 435 LENL--DILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETE 492
+ L D LL L++L L+ N +S +T + LE+L LG N ++ +
Sbjct: 278 VAGLLEDTFPGLLG---LRVLRLSHNAIASLR-PRTFKDLHFLEELQLGHNRIR-----Q 328
Query: 493 LCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP--ANL 550
L FEGL L+VL L+HN L + G F LT + ++L+ N L L L
Sbjct: 329 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 388
Query: 551 EILDISRNQLLAPNPDVFVSLSVL 574
L + + L P F LS L
Sbjct: 389 HSLHLEGSCLGRIRPHTFTGLSGL 412
Score = 89.0 bits (219), Expect = 2e-17
Identities = 81/282 (28%), Positives = 127/282 (45%), Gaps = 18/282 (6%)
Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPK 361
S+ F+ L L LNL ++ + +A GL+NL L+L N L L F P
Sbjct: 88 SVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPA 147
Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI-----HFIPSIPDIFLSGNKLV 416
+A + L N ++ ++D F+ L L L+L N+L + + S+ ++ L+GN+L
Sbjct: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 207
Query: 417 TLPKINLTA----NLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSEN 472
L + + LS N L + F+ ++P LQ L L++N ++ +
Sbjct: 208 YLQPALFSGLAELRELDLSRNALRAIKANVFV-QLPRLQKLYLDRNLIAAVAPGAFLGLK 266
Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 532
+L L L N + L D F GL L+VL L+HN + SL P F L L L
Sbjct: 267 -ALRWLDLSHNRV-----AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQ 320
Query: 533 LNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVFVSLS 572
L NR+ L+ LE+L + NQL F+ L+
Sbjct: 321 LGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362
Score = 70.9 bits (172), Expect = 5e-12
Identities = 90/351 (25%), Positives = 153/351 (43%), Gaps = 10/351 (2%)
Query: 53 LSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHP 112
LS N + + F L L L LG + D AFR L +LR L L +++ +L P
Sbjct: 153 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA-AFRGLGSLRELVLAGNRLAYLQP 211
Query: 113 DAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSL 172
F GL L EL L L +K F L L +L L +N I ++ G L +L
Sbjct: 212 ALFSGLAELRELDLSRNALR--AIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLG-LKAL 268
Query: 173 KSIDFSSNQIFLVCEHELEPLQG-KTLSFFSLAANSLYSRVSVD--WGKCMNPFRNMVLE 229
+ +D S N++ + E L G + L A SL R D + + + N + +
Sbjct: 269 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 328
Query: 230 ILDVSGNGW-TVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARS 288
+ + S G +++ N + + +A + + ++ + +++ + F GL +
Sbjct: 329 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 388
Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
HL+ S + + F L L+ L L N + I +++ +GL L L+L+ N L
Sbjct: 389 HSLHLEGS--CLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 446
Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI 399
L F GL K+ Y+ L +N +A + L++ LD+ N L +
Sbjct: 447 THLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEAL 497
Score = 67.8 bits (164), Expect = 4e-11
Identities = 87/326 (26%), Positives = 139/326 (42%), Gaps = 26/326 (7%)
Query: 53 LSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHP 112
LS N +R + A+ F L +LQ L L + AF L LR LDL +++ L
Sbjct: 225 LSRNALRAIKANVFVQLPRLQKLYLDRNLIA-AVAPGAFLGLKALRWLDLSHNRVAGLLE 283
Query: 113 DAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSL 172
D F GL L LRL + A L+ F++L L L L N+IR L SF L L
Sbjct: 284 DTFPGLLGLRVLRLSHNAI--ASLRPRTFKDLHFLEELQLGHNRIRQL-AERSFEGLGQL 340
Query: 173 KSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILD 232
+ + NQ+ E G L ++A +L G C+ RN+ ++
Sbjct: 341 EVLTLDHNQL-------QEVKAGAFLGLTNVAVMNLS-------GNCL---RNLPEQVFR 383
Query: 233 VSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRH 292
G ++ + G+ I L + G I ++ + GLA +
Sbjct: 384 GLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI---EEQSLWGLAE--LLE 438
Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352
LDL+ + L R+F+ L L+ L L+ N++ ++ +A L L++S+N L L
Sbjct: 439 LDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALP 498
Query: 353 SSNFYGLPKVAYIDLQKNHIAIIQDQ 378
+S L ++ Y+ L+ N + Q
Sbjct: 499 NSLLAPLGRLRYLSLRNNSLRTFTPQ 524
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 108 bits (269), Expect = 3e-23
Identities = 164/689 (23%), Positives = 268/689 (38%), Gaps = 107/689 (15%)
Query: 5 LDLLLGVVLMAGPVFGIPS-CSFDGRIAFYRFCNLTQVPQ-VLNTTERLLLSFNYIRTVT 62
L L L VL P P+ C+ L VP+ + ERL L N I +T
Sbjct: 18 LALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRIT 77
Query: 63 ASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLF 122
F L+ L++L L + I++ AF++L L L L +K+ L FQ L
Sbjct: 78 KMDFAGLKNLRVLHLEDNQVSV-IERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLT 136
Query: 123 EL-----------RLYFCGLSD-----------AVLKDGYFRNLKALTRLDLSKNQIRSL 160
L R F G++D + ++DG FR L+ L L L+ N I S
Sbjct: 137 RLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNI-SR 195
Query: 161 YLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPL-----QGKTLSFFSLAANSLYSR---- 211
L SF + ++++ SN ++ C+ L L Q +T+ F+L ++ R
Sbjct: 196 ILVTSFNHMPKIRTLRLHSNHLY--CDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNV 253
Query: 212 --VSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLI-----LAHHI 264
V C P E + N + SN I + L+ L I
Sbjct: 254 ADVQKKEYVCPAPHS----EPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGI 309
Query: 265 MGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKI 324
+ ++IK F + ++ +D+S + + F+ LK L L L NKI
Sbjct: 310 VEIRLEQNSIKAIPAGAFTQYKK--LKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI 367
Query: 325 NKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLE 384
+IA F GL +LQ+L L+ N + L + F L + + L N + I F L+
Sbjct: 368 TEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQ 427
Query: 385 KLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYF- 443
+QTL L N + + D +L N + T ++ L+ R+ + F
Sbjct: 428 SIQTLHLAQNPFVCDCHLKWLAD-YLQDNPIETSGA--RCSSPRRLANKRISQIKSKKFR 484
Query: 444 --------------------------------------LLRVP-----HLQILILNQNRF 460
L+R+P ++ L LN N
Sbjct: 485 CSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEV 544
Query: 461 SSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPG 520
S + P+L ++ L N ++ E+ F+G + +Q L L N L ++
Sbjct: 545 SVLEATGIFKKLPNLRKINLSNNKIK-----EVREGAFDGAASVQELMLTGNQLETVHGR 599
Query: 521 VFSHLTALRGLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVF---VSLSVLD 575
VF L+ L+ L L SN + +S++ +++ +L + N++ P F VSLS ++
Sbjct: 600 VFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTIN 659
Query: 576 ITHNKFICECELSTFINWLNHTNVTIAGP 604
+ N F C C L+ WL + P
Sbjct: 660 LLSNPFNCNCHLAWLGKWLRKRRIVSGNP 688
Score = 101 bits (251), Expect = 3e-21
Identities = 139/565 (24%), Positives = 229/565 (40%), Gaps = 78/565 (13%)
Query: 90 AFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTR 149
AF L+ +D+ ++I + PDAFQGL L L LY G + G F L +L
Sbjct: 326 AFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLY--GNKITEIAKGLFDGLVSLQL 383
Query: 150 LDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLY 209
L L+ N+I L ++ +F L +L + N++ + + PLQ ++ LA N
Sbjct: 384 LLLNANKINCLRVN-TFQDLQNLNLLSLYDNKLQTISKGLFAPLQ--SIQTLHLAQNPFV 440
Query: 210 SRVSVDW--------------GKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQA 255
+ W +C +P R I + + + ++ + S
Sbjct: 441 CDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECF 500
Query: 256 FSLILAHHIMGAGFGFHNIKDPDQNTFAGLAR---SSVRHLDLSHGFVFSLNSR-VFETL 311
L+ G I D + V L L+ V L + +F+ L
Sbjct: 501 MDLVCPEKCRCEG----TIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKL 556
Query: 312 KDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNH 371
+L+ +NL+ NKI ++ + AF G ++Q L L+ N L ++ F GL + + L+ N
Sbjct: 557 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNL 616
Query: 372 IAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIH-- 429
I + + TF L ++ L L DN +TTI P F + LV+L INL +N +
Sbjct: 617 IGCVSNDTFAGLSSVRLLSLYDNRITTI-----TPGAFTT---LVSLSTINLLSNPFNCN 668
Query: 430 ---------LSENRL----ENLDILYFLLRVP----HLQILILNQNRFSSCS-GDQTPSE 471
L + R+ +FL +P +Q + N SSC + P +
Sbjct: 669 CHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQ 728
Query: 472 NPSLEQLFLGENMLQLAWETELCWDVFE----------------GLSHLQVLYLNHNYLN 515
+E + N A + DV E L HL ++ L++N ++
Sbjct: 729 CTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSIS 788
Query: 516 SLPPGVFSHLTALRGLSLNSNRL---TVLSHNDLPANLEILDISRNQLLAPNPDVF---V 569
L FS+++ L L L+ NRL V + N L +L +L + N + + F
Sbjct: 789 MLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGL-RSLRVLTLHGNDISSVPEGSFNDLT 847
Query: 570 SLSVLDITHNKFICECELSTFINWL 594
SLS L + N C+C L W+
Sbjct: 848 SLSHLALGTNPLHCDCSLRWLSEWV 872
Score = 30.4 bits (67), Expect = 7.3
Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 4/107 (3%)
Query: 51 LLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFL 110
L L N++ T L L L++L + + + F N+ +L L L +++ +
Sbjct: 757 LYLEGNHL-TAVPRELSALRHLTLIDLSNNSISM-LTNYTFSNMSHLSTLILSYNRLRCI 814
Query: 111 HPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQI 157
AF GL L L L+ G + + +G F +L +L+ L L N +
Sbjct: 815 PVHAFNGLRSLRVLTLH--GNDISSVPEGSFNDLTSLSHLALGTNPL 859
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 107 bits (268), Expect = 4e-23
Identities = 164/695 (23%), Positives = 258/695 (37%), Gaps = 120/695 (17%)
Query: 24 CSFDGRIAFYRFCNLTQVPQ-VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 82
C+ G L +P+ + TERL L+ N I + + F L+QL++L+L
Sbjct: 38 CTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQI 97
Query: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 142
+++ AF ++ L L L ++++ L FQ L L L + K FR
Sbjct: 98 G-AVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKA--FR 154
Query: 143 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS 202
L L L KNQI S +F L L+ + ++N I + + L F
Sbjct: 155 GATDLKNLQLDKNQI-SCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMP--KLRTFR 211
Query: 203 LAANSLYSRVSVDW--------------GKCMNPFRNMVLEILDVSGNGWTVDITGNF-- 246
L +N L+ + W +C P L + +V + ++ G
Sbjct: 212 LHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGR 271
Query: 247 -----------------SNAISKSQAFSLI-----LAHHIMGAGFGFHNIKDPDQNTFAG 284
SN I + L L + + IK F+
Sbjct: 272 VPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSP 331
Query: 285 LARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLS 344
+ +R +DLS+ + + F+ L+ L L L NKI + F GL LQ+L L+
Sbjct: 332 YRK--LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLN 389
Query: 345 YNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDL------------- 391
N + + F L ++ + L N I + TF L +QTL L
Sbjct: 390 ANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKW 449
Query: 392 -----RDNALTTI------------------------------HFIPSIPDIFLSG--NK 414
R N + T +FIP D L+ N
Sbjct: 450 LADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNS 509
Query: 415 LVTLP-KINLTANLIHLSENRLENLDILYFLLRVPHLQI-LILNQNRFSSCSGDQTPSEN 472
V P K AN++ S +L + R+P L LN N S +
Sbjct: 510 DVVCPHKCRCEANVVECSSLKLTKIPE-----RIPQSTAELRLNNNEISILEATGMFKKL 564
Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 532
L+++ L N + +E+ FEG + + L+L N L S+ G+F L LR L
Sbjct: 565 THLKKINLSNNKV-----SEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLM 619
Query: 533 LNSNRLTVLSHNDL---PANLEILDISRNQLLAPNP---DVFVSLSVLDITHNKFICECE 586
L +NR++ + HND N+ +L + NQ+ +P D SLS L++ N F C C+
Sbjct: 620 LRNNRISCI-HNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQ 678
Query: 587 LSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSL 621
L+ WL + P C PD + L
Sbjct: 679 LAWLGGWLRKRKIVTGNP----RCQNPDFLRQIPL 709
Score = 68.2 bits (165), Expect = 3e-11
Identities = 77/321 (23%), Positives = 135/321 (42%), Gaps = 28/321 (8%)
Query: 91 FRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRL 150
F+ L +L+ ++L ++K+ + AF+G + EL L L ++ G FR L L L
Sbjct: 561 FKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLES--IRSGMFRGLDGLRTL 618
Query: 151 DLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYS 210
L N+I ++ + SF L +++ + NQI V + LQ +LS +L AN
Sbjct: 619 MLRNNRISCIH-NDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQ--SLSTLNLLANPFNC 675
Query: 211 RVSVDW--------------GKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAF 256
+ W +C NP + + DV+ + + + + Q
Sbjct: 676 NCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCP 735
Query: 257 SLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVR-HLDLSHGFVFSLNSRVFETLKDLK 315
+ H P G+ ++ +LD G F+L T K L+
Sbjct: 736 QECACLDTVVRCSNKHLRALPK-----GIPKNVTELYLD---GNQFTLVPGQLSTFKYLQ 787
Query: 316 VLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAII 375
+++L+ NKI+ +++ +F + L L LSYN L + F GL + + L N I+ +
Sbjct: 788 LVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTL 847
Query: 376 QDQTFKFLEKLQTLDLRDNAL 396
Q+ F + L L + N L
Sbjct: 848 QEGIFADVTSLSHLAIGANPL 868
Score = 56.6 bits (135), Expect = 1e-07
Identities = 141/615 (22%), Positives = 224/615 (36%), Gaps = 96/615 (15%)
Query: 43 QVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDL 102
Q L + L+L N I + F L LQLL L + I +AF++L NL +L L
Sbjct: 354 QGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC-IRPDAFQDLQNLSLLSL 412
Query: 103 GSSKIYFLHPDAFQGLFHLFELRL----YFCGLSDAVLKDGYFRNLKALTRLDLSKNQIR 158
+KI L F L + L L + C + L D F + R
Sbjct: 413 YDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLAD--FLRTNPIETSGARCASPR 470
Query: 159 SLYLHPSFGKLNSLKSIDFSSNQIFL----------------VCEHELEPLQGKTLSFFS 202
L + G++ S K + Q F+ VC H+ + + S
Sbjct: 471 RL-ANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCR-CEANVVECSS 528
Query: 203 LAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAH 262
L + R+ + N + IL+ TG F
Sbjct: 529 LKLTKIPERIPQSTAELR--LNNNEISILEA---------TGMFKKLT------------ 565
Query: 263 HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 322
H+ + + + + F G A SV L L+ + S+ S +F L L+ L L N
Sbjct: 566 HLKKINLSNNKVSEIEDGAFEGAA--SVSELHLTANQLESIRSGMFRGLDGLRTLMLRNN 623
Query: 323 KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN------HIAIIQ 376
+I+ I +++F GL N+++L+L N + + F L ++ ++L N +A +
Sbjct: 624 RISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLG 683
Query: 377 DQTFKFLEKLQTLDLRDNALTTIHFIP----SIPDIFLSGNKLV--TLPKINLTANLIHL 430
K K+ T + R + IP + PD + LP+ L
Sbjct: 684 GWLRK--RKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACL 741
Query: 431 SEN-RLENLDILYFLLRVP-HLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLA 488
R N + +P ++ L L+ N+F+ G + + L+ + L N +
Sbjct: 742 DTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKY--LQLVDLSNNKI--- 796
Query: 489 WETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA 548
+ L F +S L L L++N L +PP F L +LR LSL+ N ++ L
Sbjct: 797 --SSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIF-- 852
Query: 549 NLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADI 608
DV SLS L I N C+C L WL+ T P
Sbjct: 853 ----------------ADV-TSLSHLAIGANPLYCDCHL----RWLSSWVKTGYKEPGIA 891
Query: 609 YCVYPDSFSGVSLFS 623
C P G L +
Sbjct: 892 RCAGPQDMEGKLLLT 906
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 104 bits (259), Expect = 4e-22
Identities = 107/394 (27%), Positives = 175/394 (44%), Gaps = 62/394 (15%)
Query: 242 ITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVF 301
+TGN + I++S+ L H ++ NI F L + L L++ F+
Sbjct: 67 LTGNNISYINESELTGL---HSLVALYLDNSNILYVYPKAFVQLRH--LYFLFLNNNFIK 121
Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPK 361
L+ +F+ L +L+ L L YN+++ + F L ++Q LNL N L L S F G+
Sbjct: 122 RLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVA 181
Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKI 421
+ +DL N+I I + F+ LE L L L N LT +PS N L +
Sbjct: 182 LRILDLSNNNILRISESGFQHLENLACLYLGSNNLTK---VPS--------NAFEVLKSL 230
Query: 422 NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLG 481
+ LS N +E + F + +L+ L+L +R + + D
Sbjct: 231 ----RRLSLSHNPIEAIQPFAF-KGLANLEYLLLKNSRIRNVTRDG-------------- 271
Query: 482 ENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL 541
F G+++L+ L L+HN L +L FS L L L L+ NR+ +
Sbjct: 272 ----------------FSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISI 315
Query: 542 SHN---DLPANLEILDISRNQLLAPNPDVFVSLSV---LDITHNKFICECELSTFINWLN 595
++ ++ A+L+IL++S N L A +P V LS L N + C C+L +WL
Sbjct: 316 DNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLA 375
Query: 596 HTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGC 629
+ +T+ +IYC P S G +L ++ C
Sbjct: 376 SSAITL-----NIYCQNPPSMRGRALRYINITNC 404
Score = 74.3 bits (181), Expect = 4e-13
Identities = 89/345 (25%), Positives = 159/345 (46%), Gaps = 28/345 (8%)
Query: 28 GRIAFYRFCNLTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTI 86
GR R L+ +P+ +T L L+ N I + S L L L L + L +
Sbjct: 41 GRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNI-LYV 99
Query: 87 DKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKA 146
+AF L +L L L ++ I L P F+GL +L L L + +S + G F +L +
Sbjct: 100 YPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVS--FVPRGVFNDLVS 157
Query: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAAN 206
+ L+L +N++ L +F + +L+ +D S+N I + E + L+ L+ L +N
Sbjct: 158 VQYLNLQRNRLTVLG-SGTFVGMVALRILDLSNNNILRISESGFQHLE--NLACLYLGSN 214
Query: 207 SLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMG 266
+L ++V + + + R + L N I Q F+ ++
Sbjct: 215 NL-TKVPSNAFEVLKSLRRLSLS-----------------HNPIEAIQPFAFKGLANLEY 256
Query: 267 AGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINK 326
I++ ++ F+G+ ++++HL LSH + +LNS F LK+L L L N+I
Sbjct: 257 LLLKNSRIRNVTRDGFSGI--NNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIIS 314
Query: 327 IADEAFYGLD-NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370
I ++ F + +L++LNLS+N L L+ L + ++ N
Sbjct: 315 IDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 99.8 bits (247), Expect = 1e-20
Identities = 116/498 (23%), Positives = 197/498 (39%), Gaps = 91/498 (18%)
Query: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAAN 206
+ RLDLS N++ S S L SL+ + ++N++ + L P+ ++ SLA N
Sbjct: 76 VARLDLSHNRL-SFIKASSMSHLQSLREVKLNNNELETI--PNLGPVSAN-ITLLSLAGN 131
Query: 207 SLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITG-----------NFSNAISKSQA 255
+ + + + F++ LE LD+S N + T N + S
Sbjct: 132 RIVEILP----EHLKEFQS--LETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPG 185
Query: 256 FSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLK 315
+ LA+ ++ + I F ++HL+L+ + +++ F+ L LK
Sbjct: 186 YFDNLANTLLVLKLNRNRISAIPPKMFK---LPQLQHLELNRNKIKNVDGLTFQGLGALK 242
Query: 316 VLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAII 375
L + N + K+ D AF+GL N+++L L +N L E+ YGL + + L +N I I
Sbjct: 243 SLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRI 302
Query: 376 QDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRL 435
++F +KL LDL T + + + D G L+ N +H+ NR+
Sbjct: 303 SPDAWEFCQKLSELDL------TFNHLSRLDDSSFLGLSLL---------NTLHIGNNRV 347
Query: 436 ENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCW 495
S D SL+ L L N +++W E
Sbjct: 348 --------------------------SYIADCAFRGLSSLKTLDLKNN--EISWTIEDMN 379
Query: 496 DVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDI 555
F GL L+ L L N + S+ F+ L AL L L+ N + L N
Sbjct: 380 GAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF--------- 430
Query: 556 SRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDS 615
L L + + +C+C+L W+ N + C +P
Sbjct: 431 ----------SQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSF---VNASCAHPQL 477
Query: 616 FSGVSLFSLSTEG--CDE 631
G S+F++S +G CD+
Sbjct: 478 LKGRSIFAVSPDGFVCDD 495
Score = 51.2 bits (121), Expect = 4e-06
Identities = 56/192 (29%), Positives = 87/192 (45%), Gaps = 18/192 (9%)
Query: 53 LSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHP 112
L+FN++ + SSF L L L +G+ D AFR L +L+ LDL +++I +
Sbjct: 318 LTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC-AFRGLSSLKTLDLKNNEISWTIE 376
Query: 113 D---AFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKL 169
D AF GL L RL G + F L AL LDLS N I SL + +F ++
Sbjct: 377 DMNGAFSGLDKL--RRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN-AFSQM 433
Query: 170 NSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLE 229
L+ + +++ + C+ + P +A N+ S V+ C +P
Sbjct: 434 KKLQQLHLNTSSLLCDCQLKWLPQW--------VAENNFQSFVN---ASCAHPQLLKGRS 482
Query: 230 ILDVSGNGWTVD 241
I VS +G+ D
Sbjct: 483 IFAVSPDGFVCD 494
Score = 47.8 bits (112), Expect = 4e-05
Identities = 74/294 (25%), Positives = 117/294 (39%), Gaps = 56/294 (19%)
Query: 94 LPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLS 153
LP L+ L+L +KI + FQGL L L++ G++ L DG F L + L L
Sbjct: 214 LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK--LMDGAFWGLSNMEILQLD 271
Query: 154 KNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVS 213
N + + +G L L+ + S N I +R+S
Sbjct: 272 HNNLTEITKGWLYGLL-MLQELHLSQNAI---------------------------NRIS 303
Query: 214 VD-WGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFH 272
D W C +D+T N + + S L L + + G +
Sbjct: 304 PDAWEFCQKLSE---------------LDLTFNHLSRLDDSSFLGLSLLNTL---HIGNN 345
Query: 273 NIKDPDQNTFAGLARSSVRHLDLSH---GFVFSLNSRVFETLKDLKVLNLAYNKINKIAD 329
+ F GL SS++ LDL + + + F L L+ L L N+I I
Sbjct: 346 RVSYIADCAFRGL--SSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITK 403
Query: 330 EAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFL 383
+AF GLD L+ L+LS N + L + F + K+ + L N +++ D K+L
Sbjct: 404 KAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHL--NTSSLLCDCQLKWL 455
Score = 35.8 bits (81), Expect = 0.17
Identities = 44/163 (26%), Positives = 75/163 (46%), Gaps = 16/163 (9%)
Query: 65 SFPFLEQLQLLEL-GSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFE 123
+F L++L+ L L G++ +T K+AF L L LDL + I L +AF + L +
Sbjct: 381 AFSGLDKLRRLILQGNRIRSIT--KKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 438
Query: 124 LRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSI-------- 175
L L + ++L D + L + ++ + + HP K S+ ++
Sbjct: 439 LHLN----TSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCD 494
Query: 176 DFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGK 218
DF QI + E + ++G LSF AA+S S ++ W K
Sbjct: 495 DFPKPQITVQPETQ-SAIKGSNLSFICSAASSSDSPMTFAWKK 536
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 99.0 bits (245), Expect = 2e-20
Identities = 116/517 (22%), Positives = 205/517 (39%), Gaps = 97/517 (18%)
Query: 118 LFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNS-LKSID 176
LFH+ L LS +K +L++L + L+ N++ ++ P+ G +++ + +
Sbjct: 13 LFHISRPDLSHNRLS--FIKASSMSHLQSLREVKLNNNELETI---PNLGPVSANITLLS 67
Query: 177 FSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGN 236
+ N+I + L+ Q +L L++N++ + F + L+ L ++ N
Sbjct: 68 LAGNRIVEILPEHLKEFQ--SLETLDLSSNNI--------SELQTAFPALQLKYLYLNSN 117
Query: 237 GWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLS 296
T G F N LA+ ++ + I F ++HL+L+
Sbjct: 118 RVTSMEPGYFDN-----------LANTLLVLKLNRNRISAIPPKMFK---LPQLQHLELN 163
Query: 297 HGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNF 356
+ +++ F+ L LK L + N + K+ D AF+GL N+++L L +N L E+
Sbjct: 164 RNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWL 223
Query: 357 YGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLV 416
YGL + + L +N I I ++F +KL LDL T + + + D G L+
Sbjct: 224 YGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL------TFNHLSRLDDSSFLGLSLL 277
Query: 417 TLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLE 476
N +H+ NR+ S D SL+
Sbjct: 278 ---------NTLHIGNNRV--------------------------SYIADCAFRGLSSLK 302
Query: 477 QLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN 536
L L N +++W E F GL L+ L L N + S+ F+ L AL L L+ N
Sbjct: 303 TLDLKNN--EISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN 360
Query: 537 RLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNH 596
+ L N L L + + +C+C+L W+
Sbjct: 361 AIMSLQGNAF-------------------SQMKKLQQLHLNTSSLLCDCQLKWLPQWVAE 401
Query: 597 TNVTIAGPPADIYCVYPDSFSGVSLFSLSTEG--CDE 631
N + C +P G S+F++S +G CD+
Sbjct: 402 NNFQSF---VNASCAHPQLLKGRSIFAVSPDGFVCDD 435
Score = 51.2 bits (121), Expect = 4e-06
Identities = 56/192 (29%), Positives = 87/192 (45%), Gaps = 18/192 (9%)
Query: 53 LSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHP 112
L+FN++ + SSF L L L +G+ D AFR L +L+ LDL +++I +
Sbjct: 258 LTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC-AFRGLSSLKTLDLKNNEISWTIE 316
Query: 113 D---AFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKL 169
D AF GL L RL G + F L AL LDLS N I SL + +F ++
Sbjct: 317 DMNGAFSGLDKL--RRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN-AFSQM 373
Query: 170 NSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLE 229
L+ + +++ + C+ + P +A N+ S V+ C +P
Sbjct: 374 KKLQQLHLNTSSLLCDCQLKWLPQW--------VAENNFQSFVN---ASCAHPQLLKGRS 422
Query: 230 ILDVSGNGWTVD 241
I VS +G+ D
Sbjct: 423 IFAVSPDGFVCD 434
Score = 47.8 bits (112), Expect = 4e-05
Identities = 74/294 (25%), Positives = 117/294 (39%), Gaps = 56/294 (19%)
Query: 94 LPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLS 153
LP L+ L+L +KI + FQGL L L++ G++ L DG F L + L L
Sbjct: 154 LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK--LMDGAFWGLSNMEILQLD 211
Query: 154 KNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVS 213
N + + +G L L+ + S N I +R+S
Sbjct: 212 HNNLTEITKGWLYGLL-MLQELHLSQNAI---------------------------NRIS 243
Query: 214 VD-WGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFH 272
D W C +D+T N + + S L L + + G +
Sbjct: 244 PDAWEFCQKLSE---------------LDLTFNHLSRLDDSSFLGLSLLNTL---HIGNN 285
Query: 273 NIKDPDQNTFAGLARSSVRHLDLSH---GFVFSLNSRVFETLKDLKVLNLAYNKINKIAD 329
+ F GL SS++ LDL + + + F L L+ L L N+I I
Sbjct: 286 RVSYIADCAFRGL--SSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITK 343
Query: 330 EAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFL 383
+AF GLD L+ L+LS N + L + F + K+ + L N +++ D K+L
Sbjct: 344 KAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHL--NTSSLLCDCQLKWL 395
Score = 35.8 bits (81), Expect = 0.17
Identities = 44/163 (26%), Positives = 75/163 (46%), Gaps = 16/163 (9%)
Query: 65 SFPFLEQLQLLEL-GSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFE 123
+F L++L+ L L G++ +T K+AF L L LDL + I L +AF + L +
Sbjct: 321 AFSGLDKLRRLILQGNRIRSIT--KKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 378
Query: 124 LRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSI-------- 175
L L + ++L D + L + ++ + + HP K S+ ++
Sbjct: 379 LHLN----TSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCD 434
Query: 176 DFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGK 218
DF QI + E + ++G LSF AA+S S ++ W K
Sbjct: 435 DFPKPQITVQPETQ-SAIKGSNLSFICSAASSSDSPMTFAWKK 476
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 97.8 bits (242), Expect = 4e-20
Identities = 101/363 (27%), Positives = 170/363 (46%), Gaps = 31/363 (8%)
Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLD-NLQVLNLSYNL 347
S+ LDLS + + + F +K LNLA N+I + AF GL +L L LS N
Sbjct: 140 SLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNR 199
Query: 348 LGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI-----HFI 402
+ +L + LP++ +DL +N I +I+ TF+ L L+ L L+ N ++ + +
Sbjct: 200 ITQL-PVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGL 258
Query: 403 PSIPDIFLSGNKLVTLPK---INLTA-NLIHLSENRLENLDILYFLLRVPHLQILILNQN 458
+ + L N LV + LTA + +HLS N + + + L L+L+ N
Sbjct: 259 SKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSF-CQKLHELVLSFN 317
Query: 459 RFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSL- 517
+ +++ +E SL L L N + + + F+GL L+VL L+HN ++
Sbjct: 318 NLTRLD-EESLAELSSLSVLRLSHNSI-----SHIAEGAFKGLRSLRVLDLDHNEISGTI 371
Query: 518 --PPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLEILDISRNQLLAPNPDVFV---S 570
G FS L +L L+L N++ ++ LE L++ N + + D FV +
Sbjct: 372 EDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKN 431
Query: 571 LSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEG-- 628
L L I+ + F+C+C+L WL + C +P+S G S+FS+ E
Sbjct: 432 LKELHISSDSFLCDCQLKWLPPWLIGRMLQAF---VTATCAHPESLKGQSIFSVPPESFV 488
Query: 629 CDE 631
CD+
Sbjct: 489 CDD 491
Score = 84.0 bits (206), Expect = 6e-16
Identities = 91/303 (30%), Positives = 137/303 (45%), Gaps = 48/303 (15%)
Query: 317 LNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQ 376
LNL+YNK+++I F L NLQ + L+ N L + S V + LQ N I ++
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLG-AASSHVVSLFLQHNKIRSVE 131
Query: 377 DQTFKFLEKLQTLDLRDNALTTIHFI-----PSIPDIFLSGNKLVTL-----PKINLTAN 426
K L+ LDL N +T + P I ++ L+GN++ TL ++ +
Sbjct: 132 GSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLL 191
Query: 427 LIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQ 486
+ LS+NR+ L + F ++P L L LN+NR G N SLE L L N +
Sbjct: 192 TLRLSKNRITQLPVRAF--KLPRLTQLDLNRNRIRLIEGLTFQGLN-SLEVLKLQRNNI- 247
Query: 487 LAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT------- 539
++L F GLS + VL+L +N L + G LTAL L L++N +
Sbjct: 248 ----SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGW 303
Query: 540 ---------VLSHNDLP----------ANLEILDISRNQLLAPNPDVFV---SLSVLDIT 577
VLS N+L ++L +L +S N + F SL VLD+
Sbjct: 304 SFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLD 363
Query: 578 HNK 580
HN+
Sbjct: 364 HNE 366
Score = 57.0 bits (136), Expect = 7e-08
Identities = 89/359 (24%), Positives = 154/359 (42%), Gaps = 42/359 (11%)
Query: 77 LGSQYTPLT-IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV 135
L Y L+ ID F +LPNL+ + L ++++ + P H+ L L +
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRS-- 129
Query: 136 LKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQG 195
++ + +L LDLS N I + + F +K ++ + N+I + EL G
Sbjct: 130 VEGSQLKAYLSLEVLDLSLNNITEV-RNTCFPHGPPIKELNLAGNRIGTL---ELGAFDG 185
Query: 196 KTLSFFSL-AANSLYSRVSVDWGKC-------MNPFRNMVLEILDVSGNGWTVDITGNFS 247
+ S +L + + +++ V K +N R ++E L G ++++
Sbjct: 186 LSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLN-SLEVLKLQR 244
Query: 248 NAISK--SQAFSLILAHHIM------------GAGFGFHNIKD--PDQNTFAGLARSSVR 291
N ISK AF + H++ G+ +G + N+ A + R
Sbjct: 245 NNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWS 304
Query: 292 HLDLSHGFVFSLNS------RVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSY 345
H V S N+ L L VL L++N I+ IA+ AF GL +L+VL+L +
Sbjct: 305 FCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDH 364
Query: 346 NLLG---ELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHF 401
N + E S F GL ++ + L N I + + F LE L+ L+L NA+ ++ F
Sbjct: 365 NEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQF 423
Score = 53.5 bits (127), Expect = 8e-07
Identities = 83/323 (25%), Positives = 128/323 (39%), Gaps = 62/323 (19%)
Query: 37 NLTQVPQVLNTT-------ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKE 89
+L + +V NT + L L+ N I T+ +F L + L S+ +
Sbjct: 147 SLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVR 206
Query: 90 AFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTR 149
AF+ LP L LDL ++I + FQGL L L+L +S L DG F L +
Sbjct: 207 AFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISK--LTDGAFWGLSKMHV 263
Query: 150 LDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIF-LVCEHELEPLQGKTLSFFSLAANSL 208
L L N + ++ +S ++ L H+L L+ NS+
Sbjct: 264 LHLEYNSL-----------------VEVNSGSLYGLTALHQLH-----------LSNNSI 295
Query: 209 YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAG 268
W C L L +S N ++T ++++ + S++ H
Sbjct: 296 ARIHRKGWSFCQK------LHELVLSFN----NLTRLDEESLAELSSLSVLRLSH----- 340
Query: 269 FGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSL---NSRVFETLKDLKVLNLAYNKIN 325
++I + F GL S+R LDL H + S F L L L L NKI
Sbjct: 341 ---NSISHIAEGAFKGL--RSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIK 395
Query: 326 KIADEAFYGLDNLQVLNLSYNLL 348
+A AF GL+ L+ LNL N +
Sbjct: 396 SVAKRAFSGLEGLEHLNLGGNAI 418
Score = 37.0 bits (84), Expect = 0.078
Identities = 58/236 (24%), Positives = 91/236 (38%), Gaps = 49/236 (20%)
Query: 35 FCNLTQVPQV----LNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTID--- 87
F NLT++ + L++ L LS N I + +F L L++L+L TI+
Sbjct: 316 FNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTS 375
Query: 88 -----------------------KEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFEL 124
K AF L L L+LG + I + DAF + +L EL
Sbjct: 376 GAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKEL 435
Query: 125 RLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFL 184
+ SD+ L D + L + + + + HP K S+ S+ S
Sbjct: 436 HI----SSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPES----F 487
Query: 185 VCEHELEP-----------LQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLE 229
VC+ L+P + GK + F AA+S S ++ W K N +E
Sbjct: 488 VCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADME 543
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 96.7 bits (239), Expect = 8e-20
Identities = 101/353 (28%), Positives = 162/353 (45%), Gaps = 29/353 (8%)
Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLG 349
+ L L H + ++ +F+ L +L+ L L N+++ + F L+NL++L+LS N L
Sbjct: 124 LEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLT 183
Query: 350 ELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI-----HFIPS 404
L K+ + L N + + L L L N + +I +P+
Sbjct: 184 HLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPN 243
Query: 405 IPDIFLSGNKLVTLPKI------NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQN 458
+ + LS N L LP NLT L+ L EN L L + F + LQ L LN+
Sbjct: 244 LSSLTLSRNHLAFLPSALFLHSHNLT--LLTLFENPLAELPGVLFG-EMGGLQELWLNRT 300
Query: 459 RFSSCSGDQTPSENPSLEQL-FLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSL 517
+ + + +L +L +LG + + L F+GL LQVL L+ N L +L
Sbjct: 301 QLRTLPA----AAFRNLSRLRYLGVTLSPRL--SALPQGAFQGLGELQVLALHSNGLTAL 354
Query: 518 PPGVFSHLTALRGLSLNSNRLTVLSH---NDLPANLEILDISRNQLLAPNPDVFVSLSVL 574
P G+ L LR +SL NRL L +L ++LE + + NQL DVF +L L
Sbjct: 355 PDGLLRGLGKLRQVSLRRNRLRALPRALFRNL-SSLESVQLDHNQLETLPGDVFGALPRL 413
Query: 575 D---ITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSL 624
+ HN + C+C L F+ WL ++ + G C P + +G+ L++L
Sbjct: 414 TEVLLGHNSWRCDCGLGPFLGWLRQ-HLGLVGGEEPPRCAGPGAHAGLPLWAL 465
Score = 57.0 bits (136), Expect = 7e-08
Identities = 66/241 (27%), Positives = 107/241 (44%), Gaps = 35/241 (14%)
Query: 342 NLSYNLL-----GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL 396
NL++ LL G L S +F G+ + + + +HI+ + TF L KL+TL L N +
Sbjct: 51 NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKI 110
Query: 397 T-----TIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSE-----NRLENLDILYFLLR 446
T + + + +FL N L + + N+ L++L E N+L+ L F
Sbjct: 111 THLPGALLDKMVLLEQLFLDHNALRGIDQ-NMFQKLVNLQELALNQNQLDFLPASLF-TN 168
Query: 447 VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQV 506
+ +L++L L+ N + ++ LE+L L N L L + L L
Sbjct: 169 LENLKLLDLSGNNLTHLPKGLLGAQ-AKLERLLLHSNRL-----VSLDSGLLNSLGALTE 222
Query: 507 LYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL-------SHNDLPANLEILDISRNQ 559
L + N++ S+ PG F L L L+L+ N L L SH NL +L + N
Sbjct: 223 LQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSH-----NLTLLTLFENP 277
Query: 560 L 560
L
Sbjct: 278 L 278
Score = 43.1 bits (100), Expect = 0.001
Identities = 82/371 (22%), Positives = 139/371 (37%), Gaps = 67/371 (18%)
Query: 45 LNTTERLLLSFNYIRTVTASSFPFLEQLQLLELG-SQYTPLT------------------ 85
+ +RL++S ++I V +F L +L+ L L ++ T L
Sbjct: 73 MTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHN 132
Query: 86 ----IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSD-------- 133
ID+ F+ L NL+ L L +++ FL F L +L L L L+
Sbjct: 133 ALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGA 192
Query: 134 --------------AVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSS 179
L G +L ALT L +N IRS+ +F +L +L S+ S
Sbjct: 193 QAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSI-APGAFDRLPNLSSLTLSR 251
Query: 180 NQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWT 239
N + + L L+ +L N L V +G+ L+ L ++
Sbjct: 252 NHLAFLPSALF--LHSHNLTLLTLFENPLAELPGVLFGEMGG------LQELWLNRTQLR 303
Query: 240 VDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGF 299
F N +S+ + + L+ + Q F GL V L L
Sbjct: 304 TLPAAAFRN-LSRLRYLGVTLSPRLSAL----------PQGAFQGLGELQV--LALHSNG 350
Query: 300 VFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGL 359
+ +L + L L+ ++L N++ + F L +L+ + L +N L L F L
Sbjct: 351 LTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGAL 410
Query: 360 PKVAYIDLQKN 370
P++ + L N
Sbjct: 411 PRLTEVLLGHN 421
Score = 39.3 bits (90), Expect = 0.016
Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 6/127 (4%)
Query: 38 LTQVPQVL----NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRN 93
L ++P VL + L L+ +RT+ A++F L +L+ L + + + AF+
Sbjct: 278 LAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQG 337
Query: 94 LPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLS 153
L L++L L S+ + L +GL L ++ L L L FRNL +L + L
Sbjct: 338 LGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRL--RALPRALFRNLSSLESVQLD 395
Query: 154 KNQIRSL 160
NQ+ +L
Sbjct: 396 HNQLETL 402
Score = 38.1 bits (87), Expect = 0.035
Identities = 27/88 (30%), Positives = 49/88 (55%), Gaps = 5/88 (5%)
Query: 498 FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL--SHNDLPANLEILDI 555
F G++ LQ L ++ ++++++ PG FS L L+ L L+ N++T L + D LE L +
Sbjct: 70 FSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFL 129
Query: 556 SRNQLLAPNPDVF---VSLSVLDITHNK 580
N L + ++F V+L L + N+
Sbjct: 130 DHNALRGIDQNMFQKLVNLQELALNQNQ 157
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 96.3 bits (238), Expect = 1e-19
Identities = 110/397 (27%), Positives = 166/397 (41%), Gaps = 69/397 (17%)
Query: 228 LEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLAR 287
LE L+V+G+ + T FSN S + F+ ++ + F LA
Sbjct: 99 LEDLEVTGSSFLNLSTNIFSNLTSLGKLT------------LNFNMLEALPEGLFQHLA- 145
Query: 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347
++ L L + +L R+F+ L LK LNLA N + ++ +E F+ L +LQ L LS N
Sbjct: 146 -ALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNA 204
Query: 348 LGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD 407
L L F L + + L N+I+ + Q F L L+ L L+ NA+T +
Sbjct: 205 LSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHL-------- 256
Query: 408 IFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ 467
+++ A+L L L + + +LRV +
Sbjct: 257 ------------PLSIFASL-----GNLTFLSLQWNMLRVLPAGLF-------------- 285
Query: 468 TPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527
+ P L L L N L+ E F LS+L+ L L++N + LP G+F L
Sbjct: 286 --AHTPCLVGLSLTHNQLETVAE-----GTFAHLSNLRSLMLSYNAITHLPAGIFRDLEE 338
Query: 528 LRGLSLNSNRLTVLSHNDLPAN---LEILDISRNQLLAPNPDVF---VSLSVLDITHNKF 581
L L L SN LT L H L N LE+L +S+NQL +F +L L + N +
Sbjct: 339 LVKLYLGSNNLTAL-HPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPW 397
Query: 582 ICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSG 618
C+C L+ NWL + YC P G
Sbjct: 398 QCDCHLAYLFNWLQQYTDRLLN--IQTYCAGPAYLKG 432
Score = 74.7 bits (182), Expect = 3e-13
Identities = 95/375 (25%), Positives = 160/375 (42%), Gaps = 53/375 (14%)
Query: 49 ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIY 108
+ + S + TV P+ + + +E + +T T++ AF + PNL + ++++
Sbjct: 31 QEVFCSDEELATVPLDIPPYTKNIIFVE--TSFT--TLETRAFGSNPNLTKVVFLNTQLC 86
Query: 109 FLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGK 168
PDAF GL L +L + G S L F NL +L +L L+ N + +L F
Sbjct: 87 QFRPDAFGGLPRLEDLEV--TGSSFLNLSTNIFSNLTSLGKLTLNFNMLEAL-PEGLFQH 143
Query: 169 LNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVL 228
L +L+S+ NQ+ + +PL L +LA N L + +P + L
Sbjct: 144 LAALESLHLQGNQLQALPRRLFQPL--THLKTLNLAQNLLAQLPE----ELFHPLTS--L 195
Query: 229 EILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFA----- 283
+ L +S N + G F S + F +NI + F+
Sbjct: 196 QTLKLSNNALSGLPQGVFGKLGSLQELF------------LDSNNISELPPQVFSQLFCL 243
Query: 284 ---GLARSSVRHLDLSHGFVFSLNSRVFETLK----------------DLKVLNLAYNKI 324
L R+++ HL LS SL + F +L+ L L+L +N++
Sbjct: 244 ERLWLQRNAITHLPLS--IFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQL 301
Query: 325 NKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLE 384
+A+ F L NL+ L LSYN + L + F L ++ + L N++ + F+ L
Sbjct: 302 ETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLS 361
Query: 385 KLQTLDLRDNALTTI 399
KL+ L L N LTT+
Sbjct: 362 KLELLSLSKNQLTTL 376
Score = 39.3 bits (90), Expect = 0.016
Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Query: 45 LNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGS 104
L+ L+LS+N I + A F LE+L L LGS + F+NL L +L L
Sbjct: 312 LSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSN-NLTALHPALFQNLSKLELLSLSK 370
Query: 105 SKIYFLHPDAFQGLFHLFELRLY 127
+++ L F ++LF L L+
Sbjct: 371 NQLTTLPEGIFDTNYNLFNLALH 393
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 95.5 bits (236), Expect = 2e-19
Identities = 86/279 (30%), Positives = 139/279 (49%), Gaps = 30/279 (10%)
Query: 270 GFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIAD 329
GFH++ + GL+ L H + L F + L L+L +N+I+ + +
Sbjct: 51 GFHSVPNATDKGSLGLS--------LRHNHITELERDQFASFSQLTWLHLDHNQISTVKE 102
Query: 330 EAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTL 389
+AF GL L+ L LS N + L ++ F L + +DL N ++ + + F L KLQTL
Sbjct: 103 DAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTL 162
Query: 390 DLRDNALTTIHF-----IPSIPDIFLSGNKLVTLPKINLTANLI-----HLSENRLENLD 439
LR N+L TI S+ + LS N+L +L + N A LI HL N+L ++
Sbjct: 163 HLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLAR-NGFAGLIKLRELHLEHNQLTKIN 221
Query: 440 ILYFLLRVPHLQILILNQNRFS--SCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDV 497
+F LR+ L L L N+ S +C + T +LE+L L N ++ T V
Sbjct: 222 FAHF-LRLSSLHTLFLQWNKISNLTCGMEWTWG---TLEKLDLTGNEIKAIDLT-----V 272
Query: 498 FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN 536
FE + +L++L +++N LNSL + + L +L + L+ N
Sbjct: 273 FETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
Score = 69.7 bits (169), Expect = 1e-11
Identities = 72/262 (27%), Positives = 111/262 (42%), Gaps = 48/262 (18%)
Query: 317 LNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQ 376
L+L +N I ++ + F L L+L +N + + F GL K+ + L N I +
Sbjct: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
Query: 377 DQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLE 436
+ TF L LQ LDL N L+++H P++F KL TL HL N L
Sbjct: 126 NTTFTQLINLQNLDLSFNQLSSLH-----PELFYGLRKLQTL----------HLRSNSLR 170
Query: 437 NLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWD 496
+ + F + SLE L L N L+ L +
Sbjct: 171 TIPVRLFW--------------------------DCRSLEFLDLSTNRLR-----SLARN 199
Query: 497 VFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLS--HNDLPANLEILD 554
F GL L+ L+L HN L + F L++L L L N+++ L+ LE LD
Sbjct: 200 GFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLD 259
Query: 555 ISRNQLLAPNPDVFVSLSVLDI 576
++ N++ A + VF ++ L I
Sbjct: 260 LTGNEIKAIDLTVFETMPNLKI 281
Score = 65.5 bits (158), Expect = 2e-10
Identities = 87/346 (25%), Positives = 148/346 (42%), Gaps = 60/346 (17%)
Query: 9 LGVVLMAGPVFGI---PSCSFDGRIAFYRFCNLTQVPQVLNTTER----LLLSFNYIRTV 61
+ +VL P G+ P C + ++ FY C+ V N T++ L L N+I +
Sbjct: 20 MSMVLKMLPALGMACPPKCRCE-KLLFY--CDSQGFHSVPNATDKGSLGLSLRHNHITEL 76
Query: 62 TASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHL 121
F QL L L T+ ++AF+ L L+ L L S+KI++L F L +L
Sbjct: 77 ERDQFASFSQLTWLHLDHNQIS-TVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINL 135
Query: 122 FELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQ 181
L L F LS L F L+ L L L N +R++ + F SL+ +D S+N+
Sbjct: 136 QNLDLSFNQLSS--LHPELFYGLRKLQTLHLRSNSLRTIPVR-LFWDCRSLEFLDLSTNR 192
Query: 182 IFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVD 241
+ SLA N + + + ++ N + +I
Sbjct: 193 LR------------------SLARNGFAGLIKL---RELHLEHNQLTKI----------- 220
Query: 242 ITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVF 301
NF++ + S +L L + + N+ + T+ L + LDL+ +
Sbjct: 221 ---NFAHFLRLSSLHTLFLQWNKIS------NLTCGMEWTWGTLEK-----LDLTGNEIK 266
Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347
+++ VFET+ +LK+L + NK+N + + L +L + LS NL
Sbjct: 267 AIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNL 312
Score = 51.2 bits (121), Expect = 4e-06
Identities = 32/90 (35%), Positives = 49/90 (54%), Gaps = 2/90 (2%)
Query: 491 TELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP--A 548
TEL D F S L L+L+HN ++++ F L L+ L L+SN++ L +
Sbjct: 74 TELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLI 133
Query: 549 NLEILDISRNQLLAPNPDVFVSLSVLDITH 578
NL+ LD+S NQL + +P++F L L H
Sbjct: 134 NLQNLDLSFNQLSSLHPELFYGLRKLQTLH 163
>gi|167555127 CD180 molecule [Homo sapiens]
Length = 661
Score = 92.8 bits (229), Expect = 1e-18
Identities = 155/612 (25%), Positives = 254/612 (41%), Gaps = 65/612 (10%)
Query: 38 LTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPN 96
L+++P L NTTE L SFN++ T+ +F L L L+L ++ I ++ F++
Sbjct: 44 LSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDL-TRCQINWIHEDTFQSHHQ 102
Query: 97 LRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQ 156
L L L + + F+ + G L L L G+S+ L+ NL+ L L L N
Sbjct: 103 LSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISN--LEFIPVHNLENLESLYLGSNH 160
Query: 157 IRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDW 216
I S+ F N LK +DF +N I + ++ L+ +L+ N + V
Sbjct: 161 ISSIKFPKDFPARN-LKVLDFQNNAIHYISREDMRSLE----QAINLSLNFNGNNVK--- 212
Query: 217 GKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKD 276
G + F + + + L+ G T +++ F N + S SL L F +I D
Sbjct: 213 GIELGAFDSTIFQSLNFGG---TPNLSVIF-NGLQNSTTQSLWLG--------TFEDIDD 260
Query: 277 PDQNT--FAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYG 334
D ++ GL SV L+L ++S F+ L+ L+L + K G
Sbjct: 261 EDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHL-KGLPSGMKG 319
Query: 335 LDNLQVLNLSYNLLGELYSSNFYGLPKVAYI----DLQKNHIAIIQDQTFKFLEKLQTLD 390
L+ L+ L LS N +L + P + ++ +++K H+ + + L LQTLD
Sbjct: 320 LNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGV---GCLEKLGNLQTLD 376
Query: 391 LRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTAN-LIHLSEN------RLENLDILYF 443
L N I + L L L +NL+ N + L +LE LD+ +
Sbjct: 377 LSHND------IEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFT 430
Query: 444 LLRV----------PHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETEL 493
L + LQ+L L F S + P L L L N Q T+
Sbjct: 431 RLHINAPQSPFQNLHFLQVLNLTY-CFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKT 489
Query: 494 CWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEI- 552
++ + + L+VL L+ L S+ F L + + L+ N LT S + L I
Sbjct: 490 --NLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIY 547
Query: 553 LDISRNQLLAPNPDVFVSL---SVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIY 609
L+++ N + +P + L S ++++HN C C F+ W + G +
Sbjct: 548 LNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEG-SEETT 606
Query: 610 CVYPDSFSGVSL 621
C P S GV L
Sbjct: 607 CANPPSLRGVKL 618
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 91.7 bits (226), Expect = 3e-18
Identities = 82/291 (28%), Positives = 133/291 (45%), Gaps = 48/291 (16%)
Query: 266 GAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKIN 325
G F++I+ N FAGL + +LD H ++ S++ F+ ++ LK L L+ NKI
Sbjct: 65 GLSLRFNSIQKLKSNQFAGLNQLIWLYLD--HNYISSVDEDAFQGIRRLKELILSSNKIT 122
Query: 326 KIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEK 385
+ ++ F+ + NL+ L+LSYN L L S F GL K+ + L+ N + + + F+
Sbjct: 123 YLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRN 182
Query: 386 LQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLL 445
L LDL N L + LS N L K+ +HL N+ ++ +F
Sbjct: 183 LDFLDLGYNRLRS-----------LSRNAFAGLLKLKE----LHLEHNQFSKINFAHFP- 226
Query: 446 RVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQ 505
R+ +L+ + L NR S S L W W S L
Sbjct: 227 RLFNLRSIYLQWNRIRSISQG--------------------LTWT----W------SSLH 256
Query: 506 VLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDIS 556
L L+ N + + PG F L L+ L+L+SN+LT +S + A + ++ I+
Sbjct: 257 NLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISIT 307
Score = 61.6 bits (148), Expect = 3e-09
Identities = 82/340 (24%), Positives = 142/340 (41%), Gaps = 54/340 (15%)
Query: 11 VVLMAGPVFGIP-SCSFDGRIAFYRFCNLTQVPQ-VLNTTERLLLSFNYIRTVTASSFPF 68
+V++ G P +C DG+I + +P+ + ++ L L FN I+ + ++ F
Sbjct: 24 LVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAG 83
Query: 69 LEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYF 128
L QL L L Y ++D++AF+ + L+ L L S+KI +LH F + +L L L +
Sbjct: 84 LNQLIWLYLDHNYIS-SVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSY 142
Query: 129 CGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEH 188
L L+ F+ L+ L L L + NSLK++ ++F C
Sbjct: 143 NKLQ--TLQSEQFKGLRKLIILHL---------------RSNSLKTVPI---RVFQDC-- 180
Query: 189 ELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMV-LEILDVSGNGWTVDITGNFS 247
+ L F L N L S N F ++ L+ L + N ++ +F
Sbjct: 181 -------RNLDFLDLGYNRLRSL-------SRNAFAGLLKLKELHLEHNQFSKINFAHFP 226
Query: 248 NAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRV 307
+ + ++ I+ Q SS+ +LDLS + +
Sbjct: 227 RLFNLRSIY------------LQWNRIRSISQGLT--WTWSSLHNLDLSGNDIQGIEPGT 272
Query: 308 FETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347
F+ L +L+ LNL NK+ I+ E +L + LS N+
Sbjct: 273 FKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNM 312
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/84 (39%), Positives = 46/84 (54%), Gaps = 4/84 (4%)
Query: 498 FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDL---PANLEILD 554
F GL+ L LYL+HNY++S+ F + L+ L L+SN++T L HN NL LD
Sbjct: 81 FAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYL-HNKTFHPVPNLRNLD 139
Query: 555 ISRNQLLAPNPDVFVSLSVLDITH 578
+S N+L + F L L I H
Sbjct: 140 LSYNKLQTLQSEQFKGLRKLIILH 163
Score = 43.1 bits (100), Expect = 0.001
Identities = 41/134 (30%), Positives = 63/134 (47%), Gaps = 9/134 (6%)
Query: 428 IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQL 487
++L N + ++D F + L+ LIL+ N+ + ++T P+L L L N LQ
Sbjct: 90 LYLDHNYISSVDEDAFQ-GIRRLKELILSSNKITYLH-NKTFHPVPNLRNLDLSYNKLQT 147
Query: 488 AWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP 547
+ F+GL L +L+L N L ++P VF L L L NRL LS N
Sbjct: 148 LQSEQ-----FKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFA 202
Query: 548 ANLEI--LDISRNQ 559
L++ L + NQ
Sbjct: 203 GLLKLKELHLEHNQ 216
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 91.7 bits (226), Expect = 3e-18
Identities = 82/291 (28%), Positives = 133/291 (45%), Gaps = 48/291 (16%)
Query: 266 GAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKIN 325
G F++I+ N FAGL + +LD H ++ S++ F+ ++ LK L L+ NKI
Sbjct: 65 GLSLRFNSIQKLKSNQFAGLNQLIWLYLD--HNYISSVDEDAFQGIRRLKELILSSNKIT 122
Query: 326 KIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEK 385
+ ++ F+ + NL+ L+LSYN L L S F GL K+ + L+ N + + + F+
Sbjct: 123 YLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRN 182
Query: 386 LQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLL 445
L LDL N L + LS N L K+ +HL N+ ++ +F
Sbjct: 183 LDFLDLGYNRLRS-----------LSRNAFAGLLKLKE----LHLEHNQFSKINFAHFP- 226
Query: 446 RVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQ 505
R+ +L+ + L NR S S L W W S L
Sbjct: 227 RLFNLRSIYLQWNRIRSISQG--------------------LTWT----W------SSLH 256
Query: 506 VLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDIS 556
L L+ N + + PG F L L+ L+L+SN+LT +S + A + ++ I+
Sbjct: 257 NLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISIT 307
Score = 61.6 bits (148), Expect = 3e-09
Identities = 82/340 (24%), Positives = 142/340 (41%), Gaps = 54/340 (15%)
Query: 11 VVLMAGPVFGIP-SCSFDGRIAFYRFCNLTQVPQ-VLNTTERLLLSFNYIRTVTASSFPF 68
+V++ G P +C DG+I + +P+ + ++ L L FN I+ + ++ F
Sbjct: 24 LVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAG 83
Query: 69 LEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYF 128
L QL L L Y ++D++AF+ + L+ L L S+KI +LH F + +L L L +
Sbjct: 84 LNQLIWLYLDHNYIS-SVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSY 142
Query: 129 CGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEH 188
L L+ F+ L+ L L L + NSLK++ ++F C
Sbjct: 143 NKLQ--TLQSEQFKGLRKLIILHL---------------RSNSLKTVPI---RVFQDC-- 180
Query: 189 ELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMV-LEILDVSGNGWTVDITGNFS 247
+ L F L N L S N F ++ L+ L + N ++ +F
Sbjct: 181 -------RNLDFLDLGYNRLRSL-------SRNAFAGLLKLKELHLEHNQFSKINFAHFP 226
Query: 248 NAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRV 307
+ + ++ I+ Q SS+ +LDLS + +
Sbjct: 227 RLFNLRSIY------------LQWNRIRSISQGLT--WTWSSLHNLDLSGNDIQGIEPGT 272
Query: 308 FETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347
F+ L +L+ LNL NK+ I+ E +L + LS N+
Sbjct: 273 FKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNM 312
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/84 (39%), Positives = 46/84 (54%), Gaps = 4/84 (4%)
Query: 498 FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDL---PANLEILD 554
F GL+ L LYL+HNY++S+ F + L+ L L+SN++T L HN NL LD
Sbjct: 81 FAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYL-HNKTFHPVPNLRNLD 139
Query: 555 ISRNQLLAPNPDVFVSLSVLDITH 578
+S N+L + F L L I H
Sbjct: 140 LSYNKLQTLQSEQFKGLRKLIILH 163
Score = 43.1 bits (100), Expect = 0.001
Identities = 41/134 (30%), Positives = 63/134 (47%), Gaps = 9/134 (6%)
Query: 428 IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQL 487
++L N + ++D F + L+ LIL+ N+ + ++T P+L L L N LQ
Sbjct: 90 LYLDHNYISSVDEDAFQ-GIRRLKELILSSNKITYLH-NKTFHPVPNLRNLDLSYNKLQT 147
Query: 488 AWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP 547
+ F+GL L +L+L N L ++P VF L L L NRL LS N
Sbjct: 148 LQSEQ-----FKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFA 202
Query: 548 ANLEI--LDISRNQ 559
L++ L + NQ
Sbjct: 203 GLLKLKELHLEHNQ 216
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 91.3 bits (225), Expect = 3e-18
Identities = 89/303 (29%), Positives = 141/303 (46%), Gaps = 44/303 (14%)
Query: 308 FETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDL 367
F L L+ L+LA NK+ + F GLD+L+ L LS N L ++ ++F + + L
Sbjct: 103 FRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQL 162
Query: 368 QKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI-----HFIPSIPDIFLSGNKLVTLPKIN 422
NH+ I D F L L L+L N+LT I + ++ + L N+L +P +
Sbjct: 163 HGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIP-MG 221
Query: 423 LTANLIHLSENRLE----------------NLDILY------------FLLRVPHLQILI 454
L++L E L+ NL LY +++P L L
Sbjct: 222 TFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLT 281
Query: 455 LNQNRFSSCS-GDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNY 513
L N S G P P+L +L+L +N + + L +VF L LQVL L+ N
Sbjct: 282 LFGNSLKELSLGIFGPM--PNLRELWLYDNHI-----SSLPDNVFSNLRQLQVLILSRNQ 334
Query: 514 LNSLPPGVFSHLTALRGLSLNSNRLTVLSHN--DLPANLEILDISRNQLLAPNPDVFVSL 571
++ + PG F+ LT LR LSL++N L L N + ANL+ + + N+L ++F ++
Sbjct: 335 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 394
Query: 572 SVL 574
+ L
Sbjct: 395 NGL 397
Score = 88.2 bits (217), Expect = 3e-17
Identities = 100/344 (29%), Positives = 146/344 (42%), Gaps = 30/344 (8%)
Query: 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347
S+++ L L + + F+ L L LNL N + I+ F L NLQVL L N
Sbjct: 155 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 214
Query: 348 LGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD 407
L ++ F GL + + LQ+N I ++ F LQ L L +N H P
Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN-----HISQLPPS 269
Query: 408 IFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ 467
IF+ LP++ N + L N L+ L + F +P+L+ L L N SS D
Sbjct: 270 IFMQ------LPQL----NRLTLFGNSLKELSLGIF-GPMPNLRELWLYDNHISSLP-DN 317
Query: 468 TPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527
S L+ L L N + + F GL+ L+ L L+ N L L VF L
Sbjct: 318 VFSNLRQLQVLILSRNQISF-----ISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 372
Query: 528 LRGLSLNSNRLTVLSHNDLPAN---LEILDISRNQLLAPNPDVF---VSLSVLDITHNKF 581
L+ +SL +NRL L N + AN L + + NQL +F L L + N +
Sbjct: 373 LQNISLQNNRLRQLPGN-IFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPW 431
Query: 582 ICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLS 625
C+ ++ NWL N G C P + G SL ++
Sbjct: 432 RCDSDILPLRNWL-LLNQPRLGTDTVPVCFSPANVRGQSLIIIN 474
Score = 76.3 bits (186), Expect = 1e-13
Identities = 102/392 (26%), Positives = 162/392 (41%), Gaps = 69/392 (17%)
Query: 67 PFLEQLQLLELGSQYTPLT-IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELR 125
PFL L+ L + L+ I AFRNL +LR L L ++K+
Sbjct: 78 PFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL------------------ 119
Query: 126 LYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPS-FGKLNSLKSIDFSSNQIFL 184
VL G F+ L +L L LS NQ+ L + P+ F + ++LK + N +
Sbjct: 120 --------QVLPIGLFQGLDSLESLLLSSNQL--LQIQPAHFSQCSNLKELQLHGNHLEY 169
Query: 185 VCEHELEPLQGKTLSFFSLAANSL---YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVD 241
+ + + L G L+ +L NSL RV G L++L + N T
Sbjct: 170 IPDGAFDHLVG--LTKLNLGKNSLTHISPRVFQHLGN---------LQVLRLYENRLTDI 218
Query: 242 ITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVF 301
G F ++ + ++ G FHN +++ L LS+ +
Sbjct: 219 PMGTFDGLVNLQELALQQNQIGLLSPGL-FHN-------------NHNLQRLYLSNNHIS 264
Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPK 361
L +F L L L L N + +++ F + NL+ L L N + L + F L +
Sbjct: 265 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 324
Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL-----TTIHFIPSIPDIFLSGNKLV 416
+ + L +N I+ I F L +L+ L L NAL + ++ +I L N+L
Sbjct: 325 LQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLR 384
Query: 417 TLPKINLTANL-----IHLSENRLENLDILYF 443
LP N+ AN+ I L N+LENL + F
Sbjct: 385 QLPG-NIFANVNGLMAIQLQNNQLENLPLGIF 415
Score = 65.9 bits (159), Expect = 2e-10
Identities = 95/355 (26%), Positives = 144/355 (40%), Gaps = 56/355 (15%)
Query: 43 QVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDL 102
Q L++ E LLLS N + + + F L+ L+L + D AF +L L L+L
Sbjct: 128 QGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDG-AFDHLVGLTKLNL 186
Query: 103 GSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYL 162
G + + + P FQ L +L LRLY L+D + G F L L L L +NQI L
Sbjct: 187 GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPM--GTFDGLVNLQELALQQNQI-GLLS 243
Query: 163 HPSFGKLNSLKSIDFSSNQIFLVCEHELEP---LQGKTLSFFSLAANSLYSRVSVDWGKC 219
F ++L+ + S+N I +L P +Q L+ +L NSL +S+
Sbjct: 244 PGLFHNNHNLQRLYLSNNHI-----SQLPPSIFMQLPQLNRLTLFGNSL-KELSLGIFGP 297
Query: 220 MNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQ 279
M R + W D ++I
Sbjct: 298 MPNLREL-----------WLYD------------------------------NHISSLPD 316
Query: 280 NTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQ 339
N F+ L + V L LS + ++ F L +L+ L+L N + + F L NLQ
Sbjct: 317 NVFSNLRQLQV--LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQ 374
Query: 340 VLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDN 394
++L N L +L + F + + I LQ N + + F L KL L L DN
Sbjct: 375 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 55.1 bits (131), Expect = 3e-07
Identities = 45/143 (31%), Positives = 70/143 (48%), Gaps = 8/143 (5%)
Query: 40 QVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRI 99
Q+PQ+ RL L N ++ ++ F + L+ L L + ++ F NL L++
Sbjct: 273 QLPQL----NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS-SLPDNVFSNLRQLQV 327
Query: 100 LDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRS 159
L L ++I F+ P AF GL L EL L+ L D L FR L L + L N++R
Sbjct: 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQD--LDGNVFRMLANLQNISLQNNRLRQ 385
Query: 160 LYLHPSFGKLNSLKSIDFSSNQI 182
L + F +N L +I +NQ+
Sbjct: 386 LPGN-IFANVNGLMAIQLQNNQL 407
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 491 TELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA-- 548
TEL F +S L L + N L+ + PG F +L +LR LSL +N+L VL
Sbjct: 72 TELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 131
Query: 549 NLEILDISRNQLLAPNPDVFVSLSVL 574
+LE L +S NQLL P F S L
Sbjct: 132 SLESLLLSSNQLLQIQPAHFSQCSNL 157
Score = 36.2 bits (82), Expect = 0.13
Identities = 45/146 (30%), Positives = 60/146 (41%), Gaps = 4/146 (2%)
Query: 40 QVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRI 99
+V Q L + L L N + + +F L LQ L L L + F N NL+
Sbjct: 197 RVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGL-LSPGLFHNNHNLQR 255
Query: 100 LDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRS 159
L L ++ I L P F L L L L+ L + L G F + L L L N I S
Sbjct: 256 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSL--GIFGPMPNLRELWLYDNHISS 313
Query: 160 LYLHPSFGKLNSLKSIDFSSNQIFLV 185
L F L L+ + S NQI +
Sbjct: 314 L-PDNVFSNLRQLQVLILSRNQISFI 338
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 91.3 bits (225), Expect = 3e-18
Identities = 89/303 (29%), Positives = 141/303 (46%), Gaps = 44/303 (14%)
Query: 308 FETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDL 367
F L L+ L+LA NK+ + F GLD+L+ L LS N L ++ ++F + + L
Sbjct: 97 FRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQL 156
Query: 368 QKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI-----HFIPSIPDIFLSGNKLVTLPKIN 422
NH+ I D F L L L+L N+LT I + ++ + L N+L +P +
Sbjct: 157 HGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIP-MG 215
Query: 423 LTANLIHLSENRLE----------------NLDILY------------FLLRVPHLQILI 454
L++L E L+ NL LY +++P L L
Sbjct: 216 TFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLT 275
Query: 455 LNQNRFSSCS-GDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNY 513
L N S G P P+L +L+L +N + + L +VF L LQVL L+ N
Sbjct: 276 LFGNSLKELSLGIFGPM--PNLRELWLYDNHI-----SSLPDNVFSNLRQLQVLILSRNQ 328
Query: 514 LNSLPPGVFSHLTALRGLSLNSNRLTVLSHN--DLPANLEILDISRNQLLAPNPDVFVSL 571
++ + PG F+ LT LR LSL++N L L N + ANL+ + + N+L ++F ++
Sbjct: 329 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 388
Query: 572 SVL 574
+ L
Sbjct: 389 NGL 391
Score = 88.2 bits (217), Expect = 3e-17
Identities = 100/344 (29%), Positives = 146/344 (42%), Gaps = 30/344 (8%)
Query: 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347
S+++ L L + + F+ L L LNL N + I+ F L NLQVL L N
Sbjct: 149 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 208
Query: 348 LGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD 407
L ++ F GL + + LQ+N I ++ F LQ L L +N H P
Sbjct: 209 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN-----HISQLPPS 263
Query: 408 IFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ 467
IF+ LP++ N + L N L+ L + F +P+L+ L L N SS D
Sbjct: 264 IFMQ------LPQL----NRLTLFGNSLKELSLGIF-GPMPNLRELWLYDNHISSLP-DN 311
Query: 468 TPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527
S L+ L L N + + F GL+ L+ L L+ N L L VF L
Sbjct: 312 VFSNLRQLQVLILSRNQISF-----ISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 366
Query: 528 LRGLSLNSNRLTVLSHNDLPAN---LEILDISRNQLLAPNPDVF---VSLSVLDITHNKF 581
L+ +SL +NRL L N + AN L + + NQL +F L L + N +
Sbjct: 367 LQNISLQNNRLRQLPGN-IFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPW 425
Query: 582 ICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLS 625
C+ ++ NWL N G C P + G SL ++
Sbjct: 426 RCDSDILPLRNWL-LLNQPRLGTDTVPVCFSPANVRGQSLIIIN 468
Score = 76.3 bits (186), Expect = 1e-13
Identities = 102/392 (26%), Positives = 162/392 (41%), Gaps = 69/392 (17%)
Query: 67 PFLEQLQLLELGSQYTPLT-IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELR 125
PFL L+ L + L+ I AFRNL +LR L L ++K+
Sbjct: 72 PFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL------------------ 113
Query: 126 LYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPS-FGKLNSLKSIDFSSNQIFL 184
VL G F+ L +L L LS NQ+ L + P+ F + ++LK + N +
Sbjct: 114 --------QVLPIGLFQGLDSLESLLLSSNQL--LQIQPAHFSQCSNLKELQLHGNHLEY 163
Query: 185 VCEHELEPLQGKTLSFFSLAANSL---YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVD 241
+ + + L G L+ +L NSL RV G L++L + N T
Sbjct: 164 IPDGAFDHLVG--LTKLNLGKNSLTHISPRVFQHLGN---------LQVLRLYENRLTDI 212
Query: 242 ITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVF 301
G F ++ + ++ G FHN +++ L LS+ +
Sbjct: 213 PMGTFDGLVNLQELALQQNQIGLLSPGL-FHN-------------NHNLQRLYLSNNHIS 258
Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPK 361
L +F L L L L N + +++ F + NL+ L L N + L + F L +
Sbjct: 259 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 318
Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL-----TTIHFIPSIPDIFLSGNKLV 416
+ + L +N I+ I F L +L+ L L NAL + ++ +I L N+L
Sbjct: 319 LQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLR 378
Query: 417 TLPKINLTANL-----IHLSENRLENLDILYF 443
LP N+ AN+ I L N+LENL + F
Sbjct: 379 QLPG-NIFANVNGLMAIQLQNNQLENLPLGIF 409
Score = 65.9 bits (159), Expect = 2e-10
Identities = 95/355 (26%), Positives = 144/355 (40%), Gaps = 56/355 (15%)
Query: 43 QVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDL 102
Q L++ E LLLS N + + + F L+ L+L + D AF +L L L+L
Sbjct: 122 QGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDG-AFDHLVGLTKLNL 180
Query: 103 GSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYL 162
G + + + P FQ L +L LRLY L+D + G F L L L L +NQI L
Sbjct: 181 GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPM--GTFDGLVNLQELALQQNQI-GLLS 237
Query: 163 HPSFGKLNSLKSIDFSSNQIFLVCEHELEP---LQGKTLSFFSLAANSLYSRVSVDWGKC 219
F ++L+ + S+N I +L P +Q L+ +L NSL +S+
Sbjct: 238 PGLFHNNHNLQRLYLSNNHI-----SQLPPSIFMQLPQLNRLTLFGNSL-KELSLGIFGP 291
Query: 220 MNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQ 279
M R + W D ++I
Sbjct: 292 MPNLREL-----------WLYD------------------------------NHISSLPD 310
Query: 280 NTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQ 339
N F+ L + V L LS + ++ F L +L+ L+L N + + F L NLQ
Sbjct: 311 NVFSNLRQLQV--LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQ 368
Query: 340 VLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDN 394
++L N L +L + F + + I LQ N + + F L KL L L DN
Sbjct: 369 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 55.1 bits (131), Expect = 3e-07
Identities = 45/143 (31%), Positives = 70/143 (48%), Gaps = 8/143 (5%)
Query: 40 QVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRI 99
Q+PQ+ RL L N ++ ++ F + L+ L L + ++ F NL L++
Sbjct: 267 QLPQL----NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS-SLPDNVFSNLRQLQV 321
Query: 100 LDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRS 159
L L ++I F+ P AF GL L EL L+ L D L FR L L + L N++R
Sbjct: 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQD--LDGNVFRMLANLQNISLQNNRLRQ 379
Query: 160 LYLHPSFGKLNSLKSIDFSSNQI 182
L + F +N L +I +NQ+
Sbjct: 380 LPGN-IFANVNGLMAIQLQNNQL 401
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 491 TELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA-- 548
TEL F +S L L + N L+ + PG F +L +LR LSL +N+L VL
Sbjct: 66 TELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 125
Query: 549 NLEILDISRNQLLAPNPDVFVSLSVL 574
+LE L +S NQLL P F S L
Sbjct: 126 SLESLLLSSNQLLQIQPAHFSQCSNL 151
Score = 36.2 bits (82), Expect = 0.13
Identities = 45/146 (30%), Positives = 60/146 (41%), Gaps = 4/146 (2%)
Query: 40 QVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRI 99
+V Q L + L L N + + +F L LQ L L L + F N NL+
Sbjct: 191 RVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGL-LSPGLFHNNHNLQR 249
Query: 100 LDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRS 159
L L ++ I L P F L L L L+ L + L G F + L L L N I S
Sbjct: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSL--GIFGPMPNLRELWLYDNHISS 307
Query: 160 LYLHPSFGKLNSLKSIDFSSNQIFLV 185
L F L L+ + S NQI +
Sbjct: 308 L-PDNVFSNLRQLQVLILSRNQISFI 332
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 90.9 bits (224), Expect = 5e-18
Identities = 100/380 (26%), Positives = 163/380 (42%), Gaps = 44/380 (11%)
Query: 239 TVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHG 298
T + GNF I+ AF + ++ I+ TF L+R + L L +
Sbjct: 63 TYSLGGNF---ITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSR--LEELYLGNN 117
Query: 299 FVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYG 358
+ +L L+ L++L N+I++++ +F GL++L L L N LG L + F
Sbjct: 118 LLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAP 177
Query: 359 LPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTL 418
L + Y+ L+ N I + F L KL+ L+L N L PS+ T
Sbjct: 178 LGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ-----PSL-------RHAATF 225
Query: 419 PKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQL 478
+ ++LI LS N L++L F +P L +L L N+ + + + +L +L
Sbjct: 226 APLRSLSSLI-LSANNLQHLGPRIF-QHLPRLGLLSLRGNQLTHLAPEAFWGLE-ALREL 282
Query: 479 FLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRL 538
L N L ++L + E L L+ L L+ N L++L P F HL LR LSL +N L
Sbjct: 283 RLEGNRL-----SQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNAL 337
Query: 539 TVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTN 598
+ LS + A +P +L LD+ N + C+C L W+ +
Sbjct: 338 SALS---------------GDIFAASP----ALYRLDLDGNGWTCDCRLRGLKRWMGDWH 378
Query: 599 VTIAGPPADIYCVYPDSFSG 618
+ C +P + G
Sbjct: 379 SQGRLLTVFVQCRHPPALRG 398
Score = 61.6 bits (148), Expect = 3e-09
Identities = 85/329 (25%), Positives = 137/329 (41%), Gaps = 54/329 (16%)
Query: 45 LNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGS 104
L RL L +N IR++ +F L +L+ L LG+ + L LRIL
Sbjct: 82 LGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQ-ALAPGTLAPLRKLRILYANG 140
Query: 105 SKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHP 164
++I L +F+GL L +LRL G + L D F L L L L N+IR L +
Sbjct: 141 NEISRLSRGSFEGLESLVKLRLD--GNALGALPDAVFAPLGNLLYLHLESNRIRFLGKN- 197
Query: 165 SFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNP-- 222
+F +L L+ ++ S+N++ H ++LS L+AN+L + + P
Sbjct: 198 AFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNL---------QHLGPRI 248
Query: 223 FRNMV-LEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNT 281
F+++ L +L + GN T H+
Sbjct: 249 FQHLPRLGLLSLRGNQLT-----------------------HLA-------------PEA 272
Query: 282 FAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVL 341
F GL ++R L L + L + + E L L+ L+L+ N+++ + F L L+ L
Sbjct: 273 FWGL--EALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLREL 330
Query: 342 NLSYNLLGELYSSNFYGLPKVAYIDLQKN 370
+L N L L F P + +DL N
Sbjct: 331 SLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 56.2 bits (134), Expect = 1e-07
Identities = 92/372 (24%), Positives = 143/372 (38%), Gaps = 69/372 (18%)
Query: 49 ERLLLSFNYIRTVT-ASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKI 107
+ LL + +R V SS P + LG + I F L LR LDL ++I
Sbjct: 37 QHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFIT-NITAFDFHRLGQLRRLDLQYNQI 95
Query: 108 YFLHPDAFQGLFHLFELR----------------------LYFCGLSDAVLKDGYFRNLK 145
LHP F+ L L EL LY G + L G F L+
Sbjct: 96 RSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLE 155
Query: 146 ALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAA 205
+L +L L N + +L F L +L + SN+I + ++ L GK L F +L+A
Sbjct: 156 SLVKLRLDGNALGAL-PDAVFAPLGNLLYLHLESNRIRFLGKNAFAQL-GK-LRFLNLSA 212
Query: 206 NSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIM 265
N L + S+ P R++ SLIL+
Sbjct: 213 NEL--QPSLRHAATFAPLRSL-----------------------------SSLILS---- 237
Query: 266 GAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKIN 325
+N++ F L R + L L + L F L+ L+ L L N+++
Sbjct: 238 -----ANNLQHLGPRIFQHLPRLGL--LSLRGNQLTHLAPEAFWGLEALRELRLEGNRLS 290
Query: 326 KIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEK 385
++ L +L+ L+LS N L L+ + F L ++ + L+ N ++ + F
Sbjct: 291 QLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPA 350
Query: 386 LQTLDLRDNALT 397
L LDL N T
Sbjct: 351 LYRLDLDGNGWT 362
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/152 (32%), Positives = 68/152 (44%), Gaps = 37/152 (24%)
Query: 91 FRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRL 150
F++LP L +L L +++ L P+AF GL L ELRL LS L L +L L
Sbjct: 249 FQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQ--LPTALLEPLHSLEAL 306
Query: 151 DLSKNQIRSLYLHP-SFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLY 209
DLS N++ + LHP +FG L L+ + +N L L G + A+ +LY
Sbjct: 307 DLSGNELSA--LHPATFGHLGRLRELSLRNN--------ALSALSGDIFA----ASPALY 352
Query: 210 SRVSVDWGKCMNPFRNMVLEILDVSGNGWTVD 241
LD+ GNGWT D
Sbjct: 353 R--------------------LDLDGNGWTCD 364
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 87.0 bits (214), Expect = 7e-17
Identities = 90/340 (26%), Positives = 154/340 (45%), Gaps = 53/340 (15%)
Query: 292 HLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGEL 351
+LDLS + L +F L+ L+ L L+ N ++ I +AF GL +L++L L N LG +
Sbjct: 70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGI 129
Query: 352 YSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI-----HFIPSIP 406
+ + LP + + L N I+++ +++F+ L L+ L L DNALT I + +P++
Sbjct: 130 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQ 189
Query: 407 DIFLSGNKLVTLPKI---NLTANLI-HLSENR--------------LENLDILYFLLR-- 446
+ L+ N++ +P NLT+ ++ HL NR LE LD+ Y L+
Sbjct: 190 AMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF 249
Query: 447 ------VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETEL------- 493
+ LQ L + N + ++ NP L+ + +N +Q +
Sbjct: 250 PVAIRTLGRLQELGFHNNNIKAIP-EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLH 308
Query: 494 ------CWDVFE-----GLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLS 542
D+ E G + L++L L + LP G+ L LR L L+ N++ L
Sbjct: 309 TLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 368
Query: 543 HNDLPANLEILDISRNQLLAPNPDVF---VSLSVLDITHN 579
LE + + N++ D F SL LD++ N
Sbjct: 369 SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 408
Score = 83.6 bits (205), Expect = 7e-16
Identities = 95/339 (28%), Positives = 150/339 (44%), Gaps = 47/339 (13%)
Query: 279 QNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNL 338
+ +F GL SS+RHL L + + R L L+ + LA N+I+ I D AF L +L
Sbjct: 155 ERSFEGL--SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSL 212
Query: 339 QVLNLSYNLLGELYSSNFYGLPKVAYIDL-----------------------QKNHIAII 375
VL+L N + L + +F GL + +DL N+I I
Sbjct: 213 VVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAI 272
Query: 376 QDQTFKFLEKLQTLDLRDNAL-----TTIHFIPSIPDIFLSG-NKLVTLPKINLTANLIH 429
++ F LQT+ DN + + ++P + + L+G + P + T +L
Sbjct: 273 PEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEI 332
Query: 430 LSENRLE-NLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSEN--PSLEQLFLGENMLQ 486
L+ R L ++P L++L L+ N+ ++ PS + LE++ L N +
Sbjct: 333 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI-----EELPSLHRCQKLEEIGLQHNRI- 386
Query: 487 LAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDL 546
W E+ D F LS LQ L L+ N + S+ P FS L +L L L N+LT L L
Sbjct: 387 --W--EIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGL 442
Query: 547 PANLEILDISRNQLL--APNPDVFVSLSVLDITHNKFIC 583
L L + N L A + D F L +L++ + C
Sbjct: 443 -GGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 480
Score = 73.2 bits (178), Expect = 1e-12
Identities = 112/416 (26%), Positives = 168/416 (40%), Gaps = 86/416 (20%)
Query: 45 LNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGS 104
L E L LS N++ + +F L L++L L + I EA LP+L+ L L +
Sbjct: 89 LRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG-GIPAEALWELPSLQSLRLDA 147
Query: 105 SKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHP 164
+ I + +F+GL L L L L++ ++ NL AL + L+ N+I + +
Sbjct: 148 NLISLVPERSFEGLSSLRHLWLDDNALTEIPVR--ALNNLPALQAMTLALNRISHIPDY- 204
Query: 165 SFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFR 224
+F L SL + +N+I + H E L
Sbjct: 205 AFQNLTSLVVLHLHNNRIQHLGTHSFEGLHN----------------------------- 235
Query: 225 NMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLIL--AHHIMGAGFGFHNIKDPDQNTF 282
LE LD++ N K Q F + + + GF +NIK + F
Sbjct: 236 ---LETLDLNYN---------------KLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF 277
Query: 283 AG----------------LARSSVRHLDLSHGFVFSLNSRV----FETLK---DLKVLNL 319
G + RS+ ++L H SLN + F LK L++L L
Sbjct: 278 MGNPLLQTIHFYDNPIQFVGRSAFQYLPKLH--TLSLNGAMDIQEFPDLKGTTSLEILTL 335
Query: 320 AYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQT 379
I + L L+VL LS+N + EL S + K+ I LQ N I I T
Sbjct: 336 TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADT 393
Query: 380 FKFLEKLQTLDLRDNALTTIH-----FIPSIPDIFLSGNKLVTLPKINLTANLIHL 430
F L LQ LDL NA+ +IH + S+ + L+ N+L TLP L L+HL
Sbjct: 394 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGL-GGLMHL 448
Score = 70.5 bits (171), Expect = 6e-12
Identities = 80/309 (25%), Positives = 131/309 (42%), Gaps = 31/309 (10%)
Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
S++ L L + + R FE L L+ L L N + +I A L LQ + L+ N +
Sbjct: 139 SLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRI 198
Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL----TTIHFIPS 404
+ F L + + L N I + +F+ L L+TLDL N L I +
Sbjct: 199 SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGR 258
Query: 405 IPDIFLSGNKLVTLPKINLTAN----LIHLSENRLENLDILYFLLRVPHLQILILNQ--- 457
+ ++ N + +P+ N IH +N ++ + F +P L L LN
Sbjct: 259 LQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQY-LPKLHTLSLNGAMD 317
Query: 458 -NRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNS 516
F G SLE L L ++L + +C + L L+VL L+HN +
Sbjct: 318 IQEFPDLKG------TTSLEILTLTRAGIRLL-PSGMC----QQLPRLRVLELSHNQIEE 366
Query: 517 LPPGVFSHLTALRGLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVFV---SL 571
LP L + L NR+ + + ++L+ LD+S N + + +P+ F SL
Sbjct: 367 LPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSL 424
Query: 572 SVLDITHNK 580
LD+T N+
Sbjct: 425 VKLDLTDNQ 433
Score = 55.5 bits (132), Expect = 2e-07
Identities = 61/203 (30%), Positives = 93/203 (45%), Gaps = 24/203 (11%)
Query: 360 PKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLP 419
P AY+DL N++ +Q F L L+ L L N L+ IP SG L +L
Sbjct: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS------HIPGQAFSG--LYSL- 116
Query: 420 KINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLF 479
++ L N+L + L +P LQ L L+ N S +++ SL L+
Sbjct: 117 ------KILMLQNNQLGGIP-AEALWELPSLQSLRLDANLISLVP-ERSFEGLSSLRHLW 168
Query: 480 LGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT 539
L +N L TE+ L LQ + L N ++ +P F +LT+L L L++NR+
Sbjct: 169 LDDNAL-----TEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQ 223
Query: 540 VLSHNDLPA--NLEILDISRNQL 560
L + NLE LD++ N+L
Sbjct: 224 HLGTHSFEGLHNLETLDLNYNKL 246
Score = 35.8 bits (81), Expect = 0.17
Identities = 40/126 (31%), Positives = 56/126 (44%), Gaps = 13/126 (10%)
Query: 51 LLLSFNYIRTVTASSFPFLEQLQLLE-LGSQYTPL-TIDKEAFRNLPNLRILDLGSSKIY 108
L LS N I + P L + Q LE +G Q+ + I + F L +L+ LDL + I
Sbjct: 357 LELSHNQIEEL-----PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 411
Query: 109 FLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN-QIRSLYLHPSFG 167
+HP+AF L L +L L+D L L L L L N + + SF
Sbjct: 412 SIHPEAFSTLHSLVKL-----DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFP 466
Query: 168 KLNSLK 173
KL L+
Sbjct: 467 KLRILE 472
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 86.3 bits (212), Expect = 1e-16
Identities = 103/358 (28%), Positives = 158/358 (44%), Gaps = 47/358 (13%)
Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352
LDLS ++ L + L L+ L+L+YN+++ + AF+GL +L L L N L +
Sbjct: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124
Query: 353 SSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSG 412
F GL + +DL+ N I + D F L LQ L++ DN H + P F
Sbjct: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDN-----HLVFVAPGAFAGL 179
Query: 413 NKL--VTLPKINLT-------ANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSC 463
KL +TL + NL+ A L L RL LDI R+P + L Q +
Sbjct: 180 AKLSTLTLERCNLSTVPGLALARLPALVALRLRELDI----GRLPAGALRGLGQLK---- 231
Query: 464 SGDQTPSENPSLEQL----FLGENMLQLAWE----TELCWDVFEGLSHLQVLYLNHNYLN 515
+ PSLE L +G N+ LA + + + LS L+VL L+ N ++
Sbjct: 232 --ELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPIS 289
Query: 516 SLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLA------PNPDV 567
++P S L L+ L L+ LT ++ + +LD++ N L P+PD
Sbjct: 290 AIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDK 349
Query: 568 FVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLS 625
V+L ++ N C+C L + H + ++ PPA C P G SL S
Sbjct: 350 LVTLR---LSGNPLTCDCRLLWLLRLRRHLDFGMS-PPA---CAGPHHVQGKSLKEFS 400
Score = 69.7 bits (169), Expect = 1e-11
Identities = 83/301 (27%), Positives = 130/301 (43%), Gaps = 25/301 (8%)
Query: 97 LRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQ 156
L+ LDL +++ L P AF GL L LRL G ++ G F L ALT LDL NQ
Sbjct: 86 LQELDLSYNQLSTLEPGAFHGLQSLLTLRLQ--GNRLRIMGPGVFSGLSALTLLDLRLNQ 143
Query: 157 IRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDW 216
I L+L +FG+L SL+ ++ N + V L LS +L +L + +
Sbjct: 144 I-VLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGL--AKLSTLTLERCNLSTVPGLAL 200
Query: 217 GKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKD 276
+ + + L LD+ G + L H+ + +++
Sbjct: 201 AR-LPALVALRLRELDI----------GRLPAGALRGLGQLKELEIHL------WPSLEA 243
Query: 277 PDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLD 336
D + GL SS L ++ + S+ + L L+VL+L+ N I+ I L
Sbjct: 244 LDPGSLVGLNLSS---LAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV 300
Query: 337 NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL 396
LQ L LS L + + F+GL +D+ N + +++ F +KL TL L N L
Sbjct: 301 RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
Query: 397 T 397
T
Sbjct: 361 T 361
Score = 40.4 bits (93), Expect = 0.007
Identities = 30/82 (36%), Positives = 41/82 (50%), Gaps = 1/82 (1%)
Query: 51 LLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFL 110
L L N +R + F L L LL+L L +D AF L +L+ L++G + + F+
Sbjct: 113 LRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDG-AFGELGSLQKLEVGDNHLVFV 171
Query: 111 HPDAFQGLFHLFELRLYFCGLS 132
P AF GL L L L C LS
Sbjct: 172 APGAFAGLAKLSTLTLERCNLS 193
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,976,450
Number of Sequences: 37866
Number of extensions: 1338746
Number of successful extensions: 6975
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 3836
Number of HSP's gapped (non-prelim): 1463
length of query: 858
length of database: 18,247,518
effective HSP length: 111
effective length of query: 747
effective length of database: 14,044,392
effective search space: 10491160824
effective search space used: 10491160824
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.