Guide to the Human Genome
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Search of human proteins with 167466175

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
         (824 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi...  1658   0.0  
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi...  1652   0.0  
gi|239758107 PREDICTED: similar to Cell division cycle 27 homolo...   130   5e-30
gi|239750229 PREDICTED: similar to Cell division cycle 27 homolo...   130   5e-30
gi|118402596 cell division cycle protein 23 [Homo sapiens]            123   6e-28
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    82   2e-15
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    82   2e-15
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom...    82   2e-15
gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens]      80   6e-15
gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens]      80   6e-15
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]       77   7e-14
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]       77   7e-14
gi|212549736 anaphase-promoting complex subunit 7 isoform a [Hom...    68   3e-11
gi|83415184 transmembrane and tetratricopeptide repeat containin...    63   1e-09
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]                     58   4e-08
gi|118766328 transmembrane and tetratricopeptide repeat containi...    58   4e-08
gi|118766330 transmembrane and tetratricopeptide repeat containi...    58   4e-08
gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo sap...    55   2e-07
gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo sap...    55   2e-07
gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo sap...    55   2e-07
gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo sap...    55   2e-07
gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo sapi...    55   2e-07
gi|224809432 transmembrane and tetratricopeptide repeat containi...    55   2e-07
gi|212549738 anaphase-promoting complex subunit 7 isoform b [Hom...    55   3e-07
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ...    54   5e-07
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ...    54   8e-07
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa...    52   2e-06
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa...    52   2e-06
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa...    52   2e-06
gi|54607135 translocase of outer mitochondrial membrane 70 homol...    52   2e-06

>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 1658 bits (4294), Expect = 0.0
 Identities = 824/824 (100%), Positives = 824/824 (100%)

Query: 1   MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL 60
           MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
Sbjct: 1   MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL 60

Query: 61  LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL 120
           LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
Sbjct: 61  LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL 120

Query: 121 LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL 180
           LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
Sbjct: 121 LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL 180

Query: 181 PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI 240
           PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI
Sbjct: 181 PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI 240

Query: 241 SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN 300
           SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN
Sbjct: 241 SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN 300

Query: 301 YTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTP 360
           YTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTP
Sbjct: 301 YTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTP 360

Query: 361 QVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQ 420
           QVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQ
Sbjct: 361 QVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQ 420

Query: 421 PNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN 480
           PNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN
Sbjct: 421 PNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN 480

Query: 481 CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS 540
           CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
Sbjct: 481 CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS 540

Query: 541 TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY 600
           TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
Sbjct: 541 TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY 600

Query: 601 AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK 660
           AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
Sbjct: 601 AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK 660

Query: 661 ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK 720
           ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
Sbjct: 661 ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK 720

Query: 721 SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID 780
           SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
Sbjct: 721 SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID 780

Query: 781 KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF 824
           KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Sbjct: 781 KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF 824


>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
           sapiens]
          Length = 830

 Score = 1652 bits (4277), Expect = 0.0
 Identities = 824/830 (99%), Positives = 824/830 (99%), Gaps = 6/830 (0%)

Query: 1   MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL 60
           MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
Sbjct: 1   MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL 60

Query: 61  LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL 120
           LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
Sbjct: 61  LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL 120

Query: 121 LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL 180
           LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
Sbjct: 121 LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL 180

Query: 181 PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI 240
           PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI
Sbjct: 181 PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI 240

Query: 241 SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN 300
           SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN
Sbjct: 241 SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN 300

Query: 301 YTNTPPVIDVPSTGAPSKK------SVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGP 354
           YTNTPPVIDVPSTGAPSKK      SVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGP
Sbjct: 301 YTNTPPVIDVPSTGAPSKKTFRVLQSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGP 360

Query: 355 QTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTN 414
           QTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTN
Sbjct: 361 QTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTN 420

Query: 415 KGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYL 474
           KGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYL
Sbjct: 421 KGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYL 480

Query: 475 ALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVE 534
           ALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVE
Sbjct: 481 ALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVE 540

Query: 535 GMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAI 594
           GMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAI
Sbjct: 541 GMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAI 600

Query: 595 QVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLA 654
           QVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLA
Sbjct: 601 QVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLA 660

Query: 655 EMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLF 714
           EMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLF
Sbjct: 661 EMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLF 720

Query: 715 ANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQ 774
           ANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQ
Sbjct: 721 ANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQ 780

Query: 775 IKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF 824
           IKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Sbjct: 781 IKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF 830


>gi|239758107 PREDICTED: similar to Cell division cycle 27 homolog
          (S. cerevisiae) [Homo sapiens]
          Length = 70

 Score =  130 bits (327), Expect = 5e-30
 Identities = 62/70 (88%), Positives = 64/70 (91%)

Query: 1  MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL 60
          M VLQEPVQAAIWQALNHYAYRD VFLAE L+AEVHSEEA+FLLATC YR GKAYKAYRL
Sbjct: 1  MMVLQEPVQAAIWQALNHYAYRDGVFLAEHLHAEVHSEEAMFLLATCSYRPGKAYKAYRL 60

Query: 61 LKGHSCTTPQ 70
          LKGHSC TPQ
Sbjct: 61 LKGHSCPTPQ 70


>gi|239750229 PREDICTED: similar to Cell division cycle 27 homolog
          (S. cerevisiae) [Homo sapiens]
          Length = 70

 Score =  130 bits (327), Expect = 5e-30
 Identities = 62/70 (88%), Positives = 64/70 (91%)

Query: 1  MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL 60
          M VLQEPVQAAIWQALNHYAYRD VFLAE L+AEVHSEEA+FLLATC YR GKAYKAYRL
Sbjct: 1  MMVLQEPVQAAIWQALNHYAYRDGVFLAEHLHAEVHSEEAMFLLATCSYRPGKAYKAYRL 60

Query: 61 LKGHSCTTPQ 70
          LKGHSC TPQ
Sbjct: 61 LKGHSCPTPQ 70


>gi|118402596 cell division cycle protein 23 [Homo sapiens]
          Length = 597

 Score =  123 bits (309), Expect = 6e-28
 Identities = 63/191 (32%), Positives = 109/191 (57%)

Query: 498 TGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSK 557
           + +++ QI  AY  + +  +A  IF+E+R+ + YR+E M+ +S  L+       LS L+ 
Sbjct: 262 SSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAH 321

Query: 558 DLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEEL 617
           +L ++DK   E  C  GN +SL+ +H+ A  +FQRA++++P Y  A+TL+GHE++  +  
Sbjct: 322 NLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNT 381

Query: 618 DKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGV 677
             A+  +R+AI VN R Y AWYGLG  Y   +       ++++A  + P  S +L  +G 
Sbjct: 382 SAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGE 441

Query: 678 VQHALKKSEKA 688
               L +  +A
Sbjct: 442 CYEKLNQLVEA 452



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 66/292 (22%), Positives = 107/292 (36%), Gaps = 44/292 (15%)

Query: 505 IGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDK 564
           + +AYF++ EY +A          + Y    + +YS  L   +K        KD   +D 
Sbjct: 89  LAKAYFDVKEYDRAAHFLHGCNSKKAYF---LYMYSRYLSGEKK--------KDDETVDS 137

Query: 565 NSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACF 624
             P       N     RE  + +    +A ++D    Y Y ++  +  L +E   A+  F
Sbjct: 138 LGPLEKGQVKN--EALRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVKE---AIDVF 192

Query: 625 RNAIRVNPRHYNAW-------------------------YGLGMIYYKQEKFSLAEMHFQ 659
             A  V P H+ AW                         + L  IY + +    A   +Q
Sbjct: 193 VEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQ 252

Query: 660 KALDIN-PQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEK 718
             +D+   +SS ++  I V  H ++  +KAL   N+    DP   +      S L     
Sbjct: 253 NLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYR-IENMDTFSNLLYVRS 311

Query: 719 YKSALQEL-EELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPK 769
            KS L  L   L +I         +IG  Y    Q   A + F  A+ L+P+
Sbjct: 312 MKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPR 363



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 33/177 (18%), Positives = 66/177 (37%), Gaps = 16/177 (9%)

Query: 503 CQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDM 562
           C IG  Y   S++ +A   F    ++    +    +       ++   A     +   ++
Sbjct: 335 CVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEV 394

Query: 563 DKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALA 622
           +K    AW   G  + + +     + +++RA Q+ PN +     LG  +    +L +A  
Sbjct: 395 NKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKK 454

Query: 623 CFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQ 679
           C+  A           Y +G +  K     LA++H Q    +        C+I  +Q
Sbjct: 455 CYWRA-----------YAVGDV-EKMALVKLAKLHEQ----LTESEQAAQCYIKYIQ 495


>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 52/194 (26%), Positives = 99/194 (51%), Gaps = 8/194 (4%)

Query: 574  GNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPR 633
            GN F+  ++ + A+K    A +   N    +  +GH+         A+  +++AI +NP+
Sbjct: 1423 GNNFAAMQDINAAMKISTTA-EFLTNRGVIHEFMGHK-------QNAMKDYQDAITLNPK 1474

Query: 634  HYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLN 693
            +  A++  G IY+   +FS A  +F KAL  +P++  +L +  +    LKK E+A +   
Sbjct: 1475 YSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFA 1534

Query: 694  KAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQT 753
              I   P      F+RA   +  ++Y+ A ++L +   + P ++LVY    KV  K+G  
Sbjct: 1535 NVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLI 1594

Query: 754  HLALMNFSWAMDLD 767
              A+ +++ A+DL+
Sbjct: 1595 EEAMADYNQALDLE 1608



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 58/221 (26%), Positives = 93/221 (42%), Gaps = 4/221 (1%)

Query: 572  AAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGH---EFVLTEELDKALACFRNAI 628
            A   C     E + A+ FF  A++++P +  AY   G+   E+   E   +A   F  A+
Sbjct: 1309 ATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKAL 1368

Query: 629  RVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKA 688
             +NP +  A    G     Q KF  A  HF  A+D +P++ +      VV   +  +  A
Sbjct: 1369 HINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAA 1428

Query: 689  LDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYK 748
            +  +N A+ I               F   K ++A+++ ++   + PK SL YF  G +Y 
Sbjct: 1429 MQDINAAMKISTTAEFLTNRGVIHEFMGHK-QNAMKDYQDAITLNPKYSLAYFNAGNIYF 1487

Query: 749  KLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEE 789
               Q   A   FS A+  DP+     +  AI    L   EE
Sbjct: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEE 1528



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 71/315 (22%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 497  NTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLS 556
            N G +  ++G+  F L ++ QA  I          R  G   ++T + H + +     ++
Sbjct: 1275 NRGLIYVELGQYGFALEDFKQAALIS---------RTNGSLCHATAMCHHRINEFEEAVN 1325

Query: 557  KDLTDMDKNSP---EAWCAAGNCFSLQREHDIAIKF----FQRAIQVDPNYAYAYTLLGH 609
               T   K +P   +A+   GN + ++  HD A K     F +A+ ++P Y  A    G+
Sbjct: 1326 F-FTWALKINPCFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383

Query: 610  EFVLTEELDKALACFRNAIRVNPRHYNAWYGL---------------------------- 641
                  +  KA   F  AI  +P++Y A+ G                             
Sbjct: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAE 1443

Query: 642  -----GMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 696
                 G+I+        A   +Q A+ +NP+ S+   + G +    ++  +A D  +KA+
Sbjct: 1444 FLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKAL 1503

Query: 697  VIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLA 756
              DP+N     +RA      +KY+ A ++   + +  P  + VYF     Y  L Q  LA
Sbjct: 1504 KFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA 1563

Query: 757  LMNFSWAMDLDPKGA 771
              + + A+ L P  A
Sbjct: 1564 EEDLNKALSLKPNDA 1578



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 43/199 (21%), Positives = 86/199 (43%), Gaps = 4/199 (2%)

Query: 552  LSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEF 611
            + +L++++ D  K    A+C  G  +    +   A+   QR I ++P +  AY      +
Sbjct: 902  VKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIY 961

Query: 612  VLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVL 671
            +  +++++AL       + N  +  A+     IY  ++  +LA +++ +A+   P  + +
Sbjct: 962  LFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADI 1021

Query: 672  LCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQ 731
                G +     K   A+D  +K I  DPK       R      NE + +A+++   L  
Sbjct: 1022 YFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080

Query: 732  IVPKESLV---YFLIGKVY 747
            I  + S     Y L+ K Y
Sbjct: 1081 IDHQNSQARGQYLLMMKYY 1099



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 38/152 (25%), Positives = 67/152 (44%), Gaps = 10/152 (6%)

Query: 557  KDLTDMDKNSPE---AWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613
            KD  D    +P+   A+  AGN +   R+   A  +F +A++ DP   Y          +
Sbjct: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTI 1522

Query: 614  TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLL- 672
             ++ ++A   F N I   P     ++     YY  +++ LAE    KAL + P  +++  
Sbjct: 1523 LKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582

Query: 673  ------CHIGVVQHALKKSEKALDTLNKAIVI 698
                    IG+++ A+    +ALD  + A VI
Sbjct: 1583 FRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/128 (21%), Positives = 55/128 (42%), Gaps = 4/128 (3%)

Query: 645  YYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL 704
            YY+ E   L E    +  D     +   C  G +   L K + A++ L + I+++P    
Sbjct: 897  YYESEVKILTE----EINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLN 952

Query: 705  CKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAM 764
              +HR  +    +K   AL +L  + +     +  Y    ++Y+      LA++N++ A+
Sbjct: 953  AYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAI 1012

Query: 765  DLDPKGAN 772
               P  A+
Sbjct: 1013 KSTPTDAD 1020



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 21/194 (10%)

Query: 483  EAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTT 542
            E IN  +  P+  Y      C+ G  Y +L +   A      V  +E        ++   
Sbjct: 907  EEINDKTKYPAFAY------CRRGAIYRKLGKLQSAMNDLQRVILLE-------PLFLNA 953

Query: 543  LWHLQKDVALS-VLSKDLTDMD------KNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQ 595
             WH          +++ L D++      KN+ EA+ +    +  +++  +AI  + +AI+
Sbjct: 954  YWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIK 1013

Query: 596  VDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAE 655
              P  A  Y   G  + +T ++  A+  F   I  +P+  +A    G+ Y + E +  A 
Sbjct: 1014 STPTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAI 1072

Query: 656  MHFQKALDINPQSS 669
              F   L+I+ Q+S
Sbjct: 1073 EDFTALLNIDHQNS 1086


>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 52/194 (26%), Positives = 99/194 (51%), Gaps = 8/194 (4%)

Query: 574  GNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPR 633
            GN F+  ++ + A+K    A +   N    +  +GH+         A+  +++AI +NP+
Sbjct: 1423 GNNFAAMQDINAAMKISTTA-EFLTNRGVIHEFMGHK-------QNAMKDYQDAITLNPK 1474

Query: 634  HYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLN 693
            +  A++  G IY+   +FS A  +F KAL  +P++  +L +  +    LKK E+A +   
Sbjct: 1475 YSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFA 1534

Query: 694  KAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQT 753
              I   P      F+RA   +  ++Y+ A ++L +   + P ++LVY    KV  K+G  
Sbjct: 1535 NVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLI 1594

Query: 754  HLALMNFSWAMDLD 767
              A+ +++ A+DL+
Sbjct: 1595 EEAMADYNQALDLE 1608



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 58/221 (26%), Positives = 93/221 (42%), Gaps = 4/221 (1%)

Query: 572  AAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGH---EFVLTEELDKALACFRNAI 628
            A   C     E + A+ FF  A++++P +  AY   G+   E+   E   +A   F  A+
Sbjct: 1309 ATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKAL 1368

Query: 629  RVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKA 688
             +NP +  A    G     Q KF  A  HF  A+D +P++ +      VV   +  +  A
Sbjct: 1369 HINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAA 1428

Query: 689  LDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYK 748
            +  +N A+ I               F   K ++A+++ ++   + PK SL YF  G +Y 
Sbjct: 1429 MQDINAAMKISTTAEFLTNRGVIHEFMGHK-QNAMKDYQDAITLNPKYSLAYFNAGNIYF 1487

Query: 749  KLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEE 789
               Q   A   FS A+  DP+     +  AI    L   EE
Sbjct: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEE 1528



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 71/315 (22%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 497  NTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLS 556
            N G +  ++G+  F L ++ QA  I          R  G   ++T + H + +     ++
Sbjct: 1275 NRGLIYVELGQYGFALEDFKQAALIS---------RTNGSLCHATAMCHHRINEFEEAVN 1325

Query: 557  KDLTDMDKNSP---EAWCAAGNCFSLQREHDIAIKF----FQRAIQVDPNYAYAYTLLGH 609
               T   K +P   +A+   GN + ++  HD A K     F +A+ ++P Y  A    G+
Sbjct: 1326 F-FTWALKINPCFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383

Query: 610  EFVLTEELDKALACFRNAIRVNPRHYNAWYGL---------------------------- 641
                  +  KA   F  AI  +P++Y A+ G                             
Sbjct: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAE 1443

Query: 642  -----GMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 696
                 G+I+        A   +Q A+ +NP+ S+   + G +    ++  +A D  +KA+
Sbjct: 1444 FLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKAL 1503

Query: 697  VIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLA 756
              DP+N     +RA      +KY+ A ++   + +  P  + VYF     Y  L Q  LA
Sbjct: 1504 KFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA 1563

Query: 757  LMNFSWAMDLDPKGA 771
              + + A+ L P  A
Sbjct: 1564 EEDLNKALSLKPNDA 1578



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 43/199 (21%), Positives = 86/199 (43%), Gaps = 4/199 (2%)

Query: 552  LSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEF 611
            + +L++++ D  K    A+C  G  +    +   A+   QR I ++P +  AY      +
Sbjct: 902  VKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIY 961

Query: 612  VLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVL 671
            +  +++++AL       + N  +  A+     IY  ++  +LA +++ +A+   P  + +
Sbjct: 962  LFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADI 1021

Query: 672  LCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQ 731
                G +     K   A+D  +K I  DPK       R      NE + +A+++   L  
Sbjct: 1022 YFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080

Query: 732  IVPKESLV---YFLIGKVY 747
            I  + S     Y L+ K Y
Sbjct: 1081 IDHQNSQARGQYLLMMKYY 1099



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 38/152 (25%), Positives = 67/152 (44%), Gaps = 10/152 (6%)

Query: 557  KDLTDMDKNSPE---AWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613
            KD  D    +P+   A+  AGN +   R+   A  +F +A++ DP   Y          +
Sbjct: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTI 1522

Query: 614  TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLL- 672
             ++ ++A   F N I   P     ++     YY  +++ LAE    KAL + P  +++  
Sbjct: 1523 LKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582

Query: 673  ------CHIGVVQHALKKSEKALDTLNKAIVI 698
                    IG+++ A+    +ALD  + A VI
Sbjct: 1583 FRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/128 (21%), Positives = 55/128 (42%), Gaps = 4/128 (3%)

Query: 645  YYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL 704
            YY+ E   L E    +  D     +   C  G +   L K + A++ L + I+++P    
Sbjct: 897  YYESEVKILTE----EINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLN 952

Query: 705  CKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAM 764
              +HR  +    +K   AL +L  + +     +  Y    ++Y+      LA++N++ A+
Sbjct: 953  AYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAI 1012

Query: 765  DLDPKGAN 772
               P  A+
Sbjct: 1013 KSTPTDAD 1020



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 21/194 (10%)

Query: 483  EAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTT 542
            E IN  +  P+  Y      C+ G  Y +L +   A      V  +E        ++   
Sbjct: 907  EEINDKTKYPAFAY------CRRGAIYRKLGKLQSAMNDLQRVILLE-------PLFLNA 953

Query: 543  LWHLQKDVALS-VLSKDLTDMD------KNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQ 595
             WH          +++ L D++      KN+ EA+ +    +  +++  +AI  + +AI+
Sbjct: 954  YWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIK 1013

Query: 596  VDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAE 655
              P  A  Y   G  + +T ++  A+  F   I  +P+  +A    G+ Y + E +  A 
Sbjct: 1014 STPTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAI 1072

Query: 656  MHFQKALDINPQSS 669
              F   L+I+ Q+S
Sbjct: 1073 EDFTALLNIDHQNS 1086


>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
            sapiens]
          Length = 1614

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 52/194 (26%), Positives = 99/194 (51%), Gaps = 8/194 (4%)

Query: 574  GNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPR 633
            GN F+  ++ + A+K    A +   N    +  +GH+         A+  +++AI +NP+
Sbjct: 1423 GNNFAAMQDINAAMKISTTA-EFLTNRGVIHEFMGHK-------QNAMKDYQDAITLNPK 1474

Query: 634  HYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLN 693
            +  A++  G IY+   +FS A  +F KAL  +P++  +L +  +    LKK E+A +   
Sbjct: 1475 YSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFA 1534

Query: 694  KAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQT 753
              I   P      F+RA   +  ++Y+ A ++L +   + P ++LVY    KV  K+G  
Sbjct: 1535 NVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLI 1594

Query: 754  HLALMNFSWAMDLD 767
              A+ +++ A+DL+
Sbjct: 1595 EEAMADYNQALDLE 1608



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 58/221 (26%), Positives = 93/221 (42%), Gaps = 4/221 (1%)

Query: 572  AAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGH---EFVLTEELDKALACFRNAI 628
            A   C     E + A+ FF  A++++P +  AY   G+   E+   E   +A   F  A+
Sbjct: 1309 ATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKAL 1368

Query: 629  RVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKA 688
             +NP +  A    G     Q KF  A  HF  A+D +P++ +      VV   +  +  A
Sbjct: 1369 HINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAA 1428

Query: 689  LDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYK 748
            +  +N A+ I               F   K ++A+++ ++   + PK SL YF  G +Y 
Sbjct: 1429 MQDINAAMKISTTAEFLTNRGVIHEFMGHK-QNAMKDYQDAITLNPKYSLAYFNAGNIYF 1487

Query: 749  KLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEE 789
               Q   A   FS A+  DP+     +  AI    L   EE
Sbjct: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEE 1528



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 71/315 (22%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 497  NTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLS 556
            N G +  ++G+  F L ++ QA  I          R  G   ++T + H + +     ++
Sbjct: 1275 NRGLIYVELGQYGFALEDFKQAALIS---------RTNGSLCHATAMCHHRINEFEEAVN 1325

Query: 557  KDLTDMDKNSP---EAWCAAGNCFSLQREHDIAIKF----FQRAIQVDPNYAYAYTLLGH 609
               T   K +P   +A+   GN + ++  HD A K     F +A+ ++P Y  A    G+
Sbjct: 1326 F-FTWALKINPCFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383

Query: 610  EFVLTEELDKALACFRNAIRVNPRHYNAWYGL---------------------------- 641
                  +  KA   F  AI  +P++Y A+ G                             
Sbjct: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAE 1443

Query: 642  -----GMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 696
                 G+I+        A   +Q A+ +NP+ S+   + G +    ++  +A D  +KA+
Sbjct: 1444 FLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKAL 1503

Query: 697  VIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLA 756
              DP+N     +RA      +KY+ A ++   + +  P  + VYF     Y  L Q  LA
Sbjct: 1504 KFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA 1563

Query: 757  LMNFSWAMDLDPKGA 771
              + + A+ L P  A
Sbjct: 1564 EEDLNKALSLKPNDA 1578



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 43/199 (21%), Positives = 86/199 (43%), Gaps = 4/199 (2%)

Query: 552  LSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEF 611
            + +L++++ D  K    A+C  G  +    +   A+   QR I ++P +  AY      +
Sbjct: 902  VKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIY 961

Query: 612  VLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVL 671
            +  +++++AL       + N  +  A+     IY  ++  +LA +++ +A+   P  + +
Sbjct: 962  LFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADI 1021

Query: 672  LCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQ 731
                G +     K   A+D  +K I  DPK       R      NE + +A+++   L  
Sbjct: 1022 YFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080

Query: 732  IVPKESLV---YFLIGKVY 747
            I  + S     Y L+ K Y
Sbjct: 1081 IDHQNSQARGQYLLMMKYY 1099



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 38/152 (25%), Positives = 67/152 (44%), Gaps = 10/152 (6%)

Query: 557  KDLTDMDKNSPE---AWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613
            KD  D    +P+   A+  AGN +   R+   A  +F +A++ DP   Y          +
Sbjct: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTI 1522

Query: 614  TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLL- 672
             ++ ++A   F N I   P     ++     YY  +++ LAE    KAL + P  +++  
Sbjct: 1523 LKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582

Query: 673  ------CHIGVVQHALKKSEKALDTLNKAIVI 698
                    IG+++ A+    +ALD  + A VI
Sbjct: 1583 FRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/128 (21%), Positives = 55/128 (42%), Gaps = 4/128 (3%)

Query: 645  YYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL 704
            YY+ E   L E    +  D     +   C  G +   L K + A++ L + I+++P    
Sbjct: 897  YYESEVKILTE----EINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLN 952

Query: 705  CKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAM 764
              +HR  +    +K   AL +L  + +     +  Y    ++Y+      LA++N++ A+
Sbjct: 953  AYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAI 1012

Query: 765  DLDPKGAN 772
               P  A+
Sbjct: 1013 KSTPTDAD 1020



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 21/194 (10%)

Query: 483  EAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTT 542
            E IN  +  P+  Y      C+ G  Y +L +   A      V  +E        ++   
Sbjct: 907  EEINDKTKYPAFAY------CRRGAIYRKLGKLQSAMNDLQRVILLE-------PLFLNA 953

Query: 543  LWHLQKDVALS-VLSKDLTDMD------KNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQ 595
             WH          +++ L D++      KN+ EA+ +    +  +++  +AI  + +AI+
Sbjct: 954  YWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIK 1013

Query: 596  VDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAE 655
              P  A  Y   G  + +T ++  A+  F   I  +P+  +A    G+ Y + E +  A 
Sbjct: 1014 STPTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAI 1072

Query: 656  MHFQKALDINPQSS 669
              F   L+I+ Q+S
Sbjct: 1073 EDFTALLNIDHQNS 1086


>gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens]
          Length = 620

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 68/278 (24%), Positives = 122/278 (43%), Gaps = 14/278 (5%)

Query: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT 560
           V+  +   ++   ++    ++ S V   + +    + ++  TL  L K   L  LS  L 
Sbjct: 233 VVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLV 292

Query: 561 DMDKNSPEAWCAAGNCFSLQREH--DIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD 618
           D+  ++P +W A G C+ L   H  + A ++  +A  ++  Y  A+   GH F +  E D
Sbjct: 293 DLYPSNPVSWFAVG-CYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHD 351

Query: 619 KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVV 678
           +A+A +  A ++    +     +G+ Y       LAE  F +AL I P+   ++  +GVV
Sbjct: 352 QAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVV 411

Query: 679 ---QHALKKSEK-ALDTLNK------AIVIDPKNPLCKFHRASVLFANEKYKSALQELEE 728
                  K +EK  LD L K       + +D   PL   +   V    +KY  AL    +
Sbjct: 412 AFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLN-NLGHVCRKLKKYAEALDYHRQ 470

Query: 729 LKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDL 766
              ++P+ +  Y  IG ++  +G    A+  F  A+ L
Sbjct: 471 ALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL 508


>gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens]
          Length = 620

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 68/278 (24%), Positives = 122/278 (43%), Gaps = 14/278 (5%)

Query: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT 560
           V+  +   ++   ++    ++ S V   + +    + ++  TL  L K   L  LS  L 
Sbjct: 233 VVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLV 292

Query: 561 DMDKNSPEAWCAAGNCFSLQREH--DIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD 618
           D+  ++P +W A G C+ L   H  + A ++  +A  ++  Y  A+   GH F +  E D
Sbjct: 293 DLYPSNPVSWFAVG-CYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHD 351

Query: 619 KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVV 678
           +A+A +  A ++    +     +G+ Y       LAE  F +AL I P+   ++  +GVV
Sbjct: 352 QAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVV 411

Query: 679 ---QHALKKSEK-ALDTLNK------AIVIDPKNPLCKFHRASVLFANEKYKSALQELEE 728
                  K +EK  LD L K       + +D   PL   +   V    +KY  AL    +
Sbjct: 412 AFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLN-NLGHVCRKLKKYAEALDYHRQ 470

Query: 729 LKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDL 766
              ++P+ +  Y  IG ++  +G    A+  F  A+ L
Sbjct: 471 ALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL 508


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 53/222 (23%), Positives = 103/222 (46%), Gaps = 6/222 (2%)

Query: 565 NSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACF 624
           N   AW   G  F+ Q E  +AI  F++A+ +DPN+  AY  LG+        D+A+A +
Sbjct: 179 NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY 238

Query: 625 RNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKK 684
             A+ ++P H      L  +YY+Q    LA   +++A+++ P      C++         
Sbjct: 239 LRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGS 298

Query: 685 SEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIG 744
             +A D  N A+ + P +     + A++       + A++   +  ++ P+ +  +  + 
Sbjct: 299 VAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLA 358

Query: 745 KVYKKLGQTHLALMNFSWAMDLDPKGAN------NQIKEAID 780
            V ++ G+   ALM++  A+ + P  A+      N +KE  D
Sbjct: 359 SVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 400



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 51/211 (24%), Positives = 96/211 (45%)

Query: 562 MDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKAL 621
           +D N  +A+   GN     R  D A+  + RA+ + PN+A  +  L   +     +D A+
Sbjct: 210 LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAI 269

Query: 622 ACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHA 681
             +R AI + P   +A+  L     ++   + AE  +  AL + P  +  L ++  ++  
Sbjct: 270 DTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKRE 329

Query: 682 LKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYF 741
               E+A+    KA+ + P+      + ASVL    K + AL   +E  +I P  +  Y 
Sbjct: 330 QGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYS 389

Query: 742 LIGKVYKKLGQTHLALMNFSWAMDLDPKGAN 772
            +G   K++     AL  ++ A+ ++P  A+
Sbjct: 390 NMGNTLKEMQDVQGALQCYTRAIQINPAFAD 420



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 44/201 (21%), Positives = 92/201 (45%)

Query: 568 EAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA 627
           EA+   GN +  + +   AI+ ++ A+++ P++   Y  L    V   +++ A+  + +A
Sbjct: 80  EAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA 139

Query: 628 IRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 687
           ++ NP  Y     LG +     +   A+  + KA++  P  +V   ++G V +A  +   
Sbjct: 140 LQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWL 199

Query: 688 ALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVY 747
           A+    KA+ +DP       +  +VL     +  A+        + P  ++V+  +  VY
Sbjct: 200 AIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY 259

Query: 748 KKLGQTHLALMNFSWAMDLDP 768
            + G   LA+  +  A++L P
Sbjct: 260 YEQGLIDLAIDTYRRAIELQP 280



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 7/237 (2%)

Query: 555 LSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLT 614
           L  D  D   N   A  AAG+        + A++ +  A+Q +P+     + LG+     
Sbjct: 108 LKPDFIDGYINLAAALVAAGDM-------EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160

Query: 615 EELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCH 674
             L++A AC+  AI   P    AW  LG ++  Q +  LA  HF+KA+ ++P       +
Sbjct: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220

Query: 675 IGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVP 734
           +G V    +  ++A+    +A+ + P + +   + A V +       A+       ++ P
Sbjct: 221 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280

Query: 735 KESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPI 791
                Y  +    K+ G    A   ++ A+ L P  A++    A  KR   + EE +
Sbjct: 281 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAV 337



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 45/185 (24%), Positives = 85/185 (45%)

Query: 584 DIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGM 643
           D+AI  ++RAI++ P++  AY  L +       + +A  C+  A+R+ P H ++   L  
Sbjct: 266 DLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLAN 325

Query: 644 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNP 703
           I  +Q     A   ++KAL++ P+ +    ++  V     K ++AL    +AI I P   
Sbjct: 326 IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 385

Query: 704 LCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWA 763
               +  + L   +  + ALQ      QI P  +  +  +  ++K  G    A+ ++  A
Sbjct: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445

Query: 764 MDLDP 768
           + L P
Sbjct: 446 LKLKP 450



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 46/191 (24%), Positives = 78/191 (40%)

Query: 581 REHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYG 640
           R  D +  F   AI+ +P  A AY+ LG+ +    +L +A+  +R+A+R+ P   + +  
Sbjct: 59  RRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYIN 118

Query: 641 LGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDP 700
           L            A   +  AL  NP    +   +G +  AL + E+A     KAI   P
Sbjct: 119 LAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQP 178

Query: 701 KNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNF 760
              +   +   V  A  +   A+   E+   + P     Y  +G V K+      A+  +
Sbjct: 179 NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY 238

Query: 761 SWAMDLDPKGA 771
             A+ L P  A
Sbjct: 239 LRALSLSPNHA 249



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 49/216 (22%), Positives = 93/216 (43%), Gaps = 25/216 (11%)

Query: 468 EMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRR 527
           E G   LA+ +Y  + AI +  H P  +       C +  A  E     +AE  ++   R
Sbjct: 261 EQGLIDLAIDTY--RRAIELQPHFPDAY-------CNLANALKEKGSVAEAEDCYNTALR 311

Query: 528 IENYRVEGMEIYSTTLWHLQKDV-----ALSVLSKDLTDMDKNSPEAWCAAGNCFS-LQR 581
           +     + +      L +++++      A+ +  K L       PE   A  N  S LQ+
Sbjct: 312 LCPTHADSLN----NLANIKREQGNIEEAVRLYRKALEVF----PEFAAAHSNLASVLQQ 363

Query: 582 EHDI--AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWY 639
           +  +  A+  ++ AI++ P +A AY+ +G+     +++  AL C+  AI++NP   +A  
Sbjct: 364 QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHS 423

Query: 640 GLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675
            L  I+        A   ++ AL + P      C++
Sbjct: 424 NLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 459



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 41/188 (21%), Positives = 76/188 (40%), Gaps = 6/188 (3%)

Query: 597 DPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEM 656
           +P+      LL         LD++      AI+ NP    A+  LG +Y ++ +   A  
Sbjct: 41  EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIE 100

Query: 657 HFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFAN 716
           H++ AL + P       ++     A    E A+     A+  +P     +    ++L A 
Sbjct: 101 HYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160

Query: 717 EKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPK------G 770
            + + A     +  +  P  ++ +  +G V+   G+  LA+ +F  A+ LDP        
Sbjct: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220

Query: 771 ANNQIKEA 778
             N +KEA
Sbjct: 221 LGNVLKEA 228


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 53/222 (23%), Positives = 103/222 (46%), Gaps = 6/222 (2%)

Query: 565 NSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACF 624
           N   AW   G  F+ Q E  +AI  F++A+ +DPN+  AY  LG+        D+A+A +
Sbjct: 189 NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY 248

Query: 625 RNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKK 684
             A+ ++P H      L  +YY+Q    LA   +++A+++ P      C++         
Sbjct: 249 LRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGS 308

Query: 685 SEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIG 744
             +A D  N A+ + P +     + A++       + A++   +  ++ P+ +  +  + 
Sbjct: 309 VAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLA 368

Query: 745 KVYKKLGQTHLALMNFSWAMDLDPKGAN------NQIKEAID 780
            V ++ G+   ALM++  A+ + P  A+      N +KE  D
Sbjct: 369 SVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 410



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 51/211 (24%), Positives = 96/211 (45%)

Query: 562 MDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKAL 621
           +D N  +A+   GN     R  D A+  + RA+ + PN+A  +  L   +     +D A+
Sbjct: 220 LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAI 279

Query: 622 ACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHA 681
             +R AI + P   +A+  L     ++   + AE  +  AL + P  +  L ++  ++  
Sbjct: 280 DTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKRE 339

Query: 682 LKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYF 741
               E+A+    KA+ + P+      + ASVL    K + AL   +E  +I P  +  Y 
Sbjct: 340 QGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYS 399

Query: 742 LIGKVYKKLGQTHLALMNFSWAMDLDPKGAN 772
            +G   K++     AL  ++ A+ ++P  A+
Sbjct: 400 NMGNTLKEMQDVQGALQCYTRAIQINPAFAD 430



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 44/201 (21%), Positives = 92/201 (45%)

Query: 568 EAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA 627
           EA+   GN +  + +   AI+ ++ A+++ P++   Y  L    V   +++ A+  + +A
Sbjct: 90  EAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA 149

Query: 628 IRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 687
           ++ NP  Y     LG +     +   A+  + KA++  P  +V   ++G V +A  +   
Sbjct: 150 LQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWL 209

Query: 688 ALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVY 747
           A+    KA+ +DP       +  +VL     +  A+        + P  ++V+  +  VY
Sbjct: 210 AIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY 269

Query: 748 KKLGQTHLALMNFSWAMDLDP 768
            + G   LA+  +  A++L P
Sbjct: 270 YEQGLIDLAIDTYRRAIELQP 290



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 7/237 (2%)

Query: 555 LSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLT 614
           L  D  D   N   A  AAG+        + A++ +  A+Q +P+     + LG+     
Sbjct: 118 LKPDFIDGYINLAAALVAAGDM-------EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 170

Query: 615 EELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCH 674
             L++A AC+  AI   P    AW  LG ++  Q +  LA  HF+KA+ ++P       +
Sbjct: 171 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 230

Query: 675 IGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVP 734
           +G V    +  ++A+    +A+ + P + +   + A V +       A+       ++ P
Sbjct: 231 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 290

Query: 735 KESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPI 791
                Y  +    K+ G    A   ++ A+ L P  A++    A  KR   + EE +
Sbjct: 291 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAV 347



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 45/185 (24%), Positives = 85/185 (45%)

Query: 584 DIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGM 643
           D+AI  ++RAI++ P++  AY  L +       + +A  C+  A+R+ P H ++   L  
Sbjct: 276 DLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLAN 335

Query: 644 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNP 703
           I  +Q     A   ++KAL++ P+ +    ++  V     K ++AL    +AI I P   
Sbjct: 336 IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 395

Query: 704 LCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWA 763
               +  + L   +  + ALQ      QI P  +  +  +  ++K  G    A+ ++  A
Sbjct: 396 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 455

Query: 764 MDLDP 768
           + L P
Sbjct: 456 LKLKP 460



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 46/191 (24%), Positives = 78/191 (40%)

Query: 581 REHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYG 640
           R  D +  F   AI+ +P  A AY+ LG+ +    +L +A+  +R+A+R+ P   + +  
Sbjct: 69  RRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYIN 128

Query: 641 LGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDP 700
           L            A   +  AL  NP    +   +G +  AL + E+A     KAI   P
Sbjct: 129 LAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQP 188

Query: 701 KNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNF 760
              +   +   V  A  +   A+   E+   + P     Y  +G V K+      A+  +
Sbjct: 189 NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY 248

Query: 761 SWAMDLDPKGA 771
             A+ L P  A
Sbjct: 249 LRALSLSPNHA 259



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 49/216 (22%), Positives = 93/216 (43%), Gaps = 25/216 (11%)

Query: 468 EMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRR 527
           E G   LA+ +Y  + AI +  H P  +       C +  A  E     +AE  ++   R
Sbjct: 271 EQGLIDLAIDTY--RRAIELQPHFPDAY-------CNLANALKEKGSVAEAEDCYNTALR 321

Query: 528 IENYRVEGMEIYSTTLWHLQKDV-----ALSVLSKDLTDMDKNSPEAWCAAGNCFS-LQR 581
           +     + +      L +++++      A+ +  K L       PE   A  N  S LQ+
Sbjct: 322 LCPTHADSLN----NLANIKREQGNIEEAVRLYRKALEVF----PEFAAAHSNLASVLQQ 373

Query: 582 EHDI--AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWY 639
           +  +  A+  ++ AI++ P +A AY+ +G+     +++  AL C+  AI++NP   +A  
Sbjct: 374 QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHS 433

Query: 640 GLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675
            L  I+        A   ++ AL + P      C++
Sbjct: 434 NLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 469



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 41/188 (21%), Positives = 76/188 (40%), Gaps = 6/188 (3%)

Query: 597 DPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEM 656
           +P+      LL         LD++      AI+ NP    A+  LG +Y ++ +   A  
Sbjct: 51  EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIE 110

Query: 657 HFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFAN 716
           H++ AL + P       ++     A    E A+     A+  +P     +    ++L A 
Sbjct: 111 HYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 170

Query: 717 EKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPK------G 770
            + + A     +  +  P  ++ +  +G V+   G+  LA+ +F  A+ LDP        
Sbjct: 171 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 230

Query: 771 ANNQIKEA 778
             N +KEA
Sbjct: 231 LGNVLKEA 238


>gi|212549736 anaphase-promoting complex subunit 7 isoform a [Homo
           sapiens]
          Length = 599

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 67/318 (21%), Positives = 129/318 (40%), Gaps = 8/318 (2%)

Query: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT 560
           +L  +   YF   +   +   F + + ++ Y ++GM++Y   L    +   +  L   L 
Sbjct: 273 LLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLF 332

Query: 561 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKA 620
           ++     E W  +G      + +  A+    +AIQ++ N   A  L G        + +A
Sbjct: 333 NISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEA 392

Query: 621 LACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEM---HFQKALDINPQSSVLLCHIGV 677
           +  FR AIR+ P   + + GL   Y        A +   +  K L  N Q+  LL  + +
Sbjct: 393 IIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCL 452

Query: 678 VQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKES 737
                +  EKA   L+KA+   P        +A +L   +KY+  +  L         + 
Sbjct: 453 EDPVTQ--EKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRN-ALANQSDC 509

Query: 738 LVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQI 797
           +++ ++G     + +   A+  +S A+ LDP   + +  E + K    +     TQEE +
Sbjct: 510 VLHRILGDFLVAVNEYQEAMDQYSIALSLDPN--DQKSLEGMQKMEKEESPTDATQEEDV 567

Query: 798 MGTDESQESSMTDADDTQ 815
              + S E    +  D++
Sbjct: 568 DDMEGSGEEGDLEGSDSE 585


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
           [Homo sapiens]
          Length = 774

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 54/209 (25%), Positives = 92/209 (44%), Gaps = 15/209 (7%)

Query: 567 PEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRN 626
           P    A  N  +L R+   A  ++QRA+Q+ P +  A   LG+     E+ ++A+   ++
Sbjct: 406 PRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKD 465

Query: 627 AIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSE 686
           +I+  P   +A+  L  +  +QE+F  AE  +Q  +   P SS L  + GV        E
Sbjct: 466 SIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPE 525

Query: 687 KALDTLNKAIVIDPKNPLCKFHRASVL-------FANEKYKSALQELEELKQIVPKESLV 739
           KA+    +AI + P + +   +   +         A E YK ALQ   + + + P     
Sbjct: 526 KAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSP----- 580

Query: 740 YFLIGKVYKKLGQTHLALMNFSWAMDLDP 768
              +G +Y   G+   AL  +  A  L P
Sbjct: 581 ---LGALYYNTGRYEEALQIYQEAAALQP 606



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 39/175 (22%), Positives = 78/175 (44%), Gaps = 4/175 (2%)

Query: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT 560
           +L  +G  Y+    Y +A +I+ E   ++  + E     +  L  + +      ++  + 
Sbjct: 577 ILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIV 636

Query: 561 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLL----GHEFVLTEE 616
             +    E +      +S Q  HD A+    +A+Q+ P      + L    G++      
Sbjct: 637 SEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNL 696

Query: 617 LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVL 671
           LDKA   +R A+++NP    AW  +G I + + K+  A  ++++AL + P S +L
Sbjct: 697 LDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLL 751



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 54/227 (23%), Positives = 103/227 (45%), Gaps = 10/227 (4%)

Query: 547 QKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTL 606
           +K+ A+++L KD         +A+ +  +  + Q     A + +Q  I+  P+ +  +  
Sbjct: 455 KKEEAITLL-KDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNN 513

Query: 607 LGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP 666
            G   V T   +KA+A ++ AI+++P H+ A   LG +Y    + S+AE  +++AL +  
Sbjct: 514 YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH 573

Query: 667 QSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQEL 726
           ++ + L  +G + +   + E+AL    +A  + P     +   A VL    + K    E 
Sbjct: 574 KAEI-LSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTK----EA 628

Query: 727 EELKQIVPKESL----VYFLIGKVYKKLGQTHLALMNFSWAMDLDPK 769
           E++   +  E       Y L+  +Y K      AL     A+ L PK
Sbjct: 629 EKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPK 675



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 47/244 (19%), Positives = 94/244 (38%), Gaps = 13/244 (5%)

Query: 492 PSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVA 551
           PSHH      +  +GR Y  L E   AE  +    ++  ++ E +       ++  +   
Sbjct: 539 PSHHV----AMVNLGRLYRSLGENSMAEEWYKRALQVA-HKAEILSPLGALYYNTGRYEE 593

Query: 552 LSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEF 611
              + ++   +  +  E   A     ++  +   A K     +  +      Y LL   +
Sbjct: 594 ALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIY 653

Query: 612 VLTEELDKALACFRNAIRVNPRHYNA----WYGLGMIYYKQEKFSLAEMHFQKALDINPQ 667
              E  DKAL     A+++ P+        ++  G    +Q     A   ++ A+ +NP 
Sbjct: 654 SKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPD 713

Query: 668 SSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELE 727
            +    ++G +QH   K   A     +A+ + P + L K + A +    ++ +  LQE+ 
Sbjct: 714 QAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKL----DRLEKRLQEVR 769

Query: 728 ELKQ 731
           E  Q
Sbjct: 770 EKDQ 773



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 46/214 (21%), Positives = 89/214 (41%), Gaps = 12/214 (5%)

Query: 564 KNSPEAWCAAGNCFSLQR---EHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKA 620
           K SP    A  N   L R   E+ +A ++++RA+QV  + A   + LG  +  T   ++A
Sbjct: 536 KLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQV-AHKAEILSPLGALYYNTGRYEEA 594

Query: 621 LACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCH--IGVV 678
           L  ++ A  + P        L  +     +   AE        ++ ++  L C+  +  +
Sbjct: 595 LQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHI--VSEETGCLECYRLLSAI 652

Query: 679 QHALKKSEKALDTLNKAIVIDPKNPL----CKFHRASVLFANEKYKSALQELEELKQIVP 734
               +  +KALD ++KA+ + PK+P       F + + L        A +      Q+ P
Sbjct: 653 YSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNP 712

Query: 735 KESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDP 768
            ++  +  +G +    G+   A   +  A+ L P
Sbjct: 713 DQAQAWMNMGGIQHIKGKYVSARAYYERALQLVP 746



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 23/117 (19%), Positives = 55/117 (47%), Gaps = 3/117 (2%)

Query: 624 FRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALK 683
           FR+ ++  P +    Y        Q +   A  H++ AL + P+ +  L ++G +    +
Sbjct: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TR 420

Query: 684 KSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVY 740
            + +A     +A+ + P++    F+  ++L + EK + A+  L++  +  P+ +  Y
Sbjct: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAY 477


>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
          Length = 519

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 71/337 (21%), Positives = 140/337 (41%), Gaps = 41/337 (12%)

Query: 422 NINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNC 481
           NI +SLE+ +           + ++PQ  A NL++ A    +     +GK   A+  YN 
Sbjct: 82  NIQESLELFQT---------CAVLSPQ-SADNLKQVARSLFL-----LGKHKAAIEVYNE 126

Query: 482 KEAINILSHLPSHHYNTGWV-LCQIGRAYFELSEYMQAER------IFSEVRRIENYRVE 534
              +N      SH+    ++ L Q  +A  +L   +   R      +  ++  +E    +
Sbjct: 127 AAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDK 186

Query: 535 GMEIYSTT---------------LWHLQKDV---ALSVLSKDLTDMDKNSPEAWCAAGNC 576
            +E+Y                  L +LQ  +   A   L   LT  D  + +A  AAG+ 
Sbjct: 187 AIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALT-YDPTNYKAILAAGSM 245

Query: 577 FSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYN 636
                + D+A+  ++      P     +  +G  F   ++   A++C + A  + P  + 
Sbjct: 246 MQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK 305

Query: 637 AWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 696
             Y LG+++   ++++ A      A++  P+   L   + V    L+  E A     +A+
Sbjct: 306 ILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAV 365

Query: 697 VIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIV 733
            +D  NPL   + A +L+   + K+AL + +E+++ V
Sbjct: 366 HLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKV 402



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 60/274 (21%), Positives = 109/274 (39%), Gaps = 17/274 (6%)

Query: 502 LCQIGRAYFELSEYMQAERIFSEVRRIE------NYRVEGMEIYSTTLWHLQKDV--ALS 553
           L Q+ R+ F L ++  A  +++E  ++       ++ +    IY       Q  +  AL+
Sbjct: 104 LKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALN 163

Query: 554 VLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613
           +   DLT         +   G    L+ + D AI+ +++A++  P      T LG  ++ 
Sbjct: 164 LNRHDLT---------YIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQ 214

Query: 614 TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLC 673
                KA     NA+  +P +Y A    G +      F +A   ++      P+S  L  
Sbjct: 215 LGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWN 274

Query: 674 HIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIV 733
           +IG+     KK   A+  L +A  + P +    ++   V    ++Y SA   L       
Sbjct: 275 NIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQ 334

Query: 734 PKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLD 767
           PK   +Y L+      L     A   ++ A+ LD
Sbjct: 335 PKMGELYMLLAVALTNLEDIENAKRAYAEAVHLD 368



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 46/236 (19%), Positives = 99/236 (41%), Gaps = 1/236 (0%)

Query: 534 EGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRA 593
           + ++  + +L+ L K  A   +  +   +++   E     G C+   ++ + A      A
Sbjct: 102 DNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNA 161

Query: 594 IQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSL 653
           + ++  +   Y +LG   +L  +LDKA+  ++ A+  +P +      LG++Y +   +  
Sbjct: 162 LNLN-RHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQK 220

Query: 654 AEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVL 713
           A  H   AL  +P +   +   G +       + AL          P++P    +     
Sbjct: 221 AFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCF 280

Query: 714 FANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPK 769
           F  +KY +A+  L+    + P +  + + +G V+  + Q   A    S A++  PK
Sbjct: 281 FGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPK 336


>gi|118766328 transmembrane and tetratricopeptide repeat containing
           4 isoform 2 [Homo sapiens]
          Length = 741

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 38/153 (24%), Positives = 70/153 (45%)

Query: 588 KFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYK 647
           + F+ A+ V P  A  +  +G           A+  +R A+R+NP++ +A   LG I  +
Sbjct: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528

Query: 648 QEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKF 707
           + +   AE     A+ I P  +    ++G+VQ++LK+ E A  +   AI    K P C +
Sbjct: 529 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYY 588

Query: 708 HRASVLFANEKYKSALQELEELKQIVPKESLVY 740
           +   +     ++  AL        + P+ SL +
Sbjct: 589 NLGRLYADLNRHVDALNAWRNATVLKPEHSLAW 621



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 46/233 (19%), Positives = 95/233 (40%), Gaps = 34/233 (14%)

Query: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 645
           AI++++ A++++P Y +A   LG+      EL +A      A+++ P    AW  LG++ 
Sbjct: 501 AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQ 560

Query: 646 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLC 705
              ++F  AE  ++ A+    +      ++G +   L +   AL+    A V+ P++ L 
Sbjct: 561 NSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLA 620

Query: 706 ----------------------------------KFHRASVLFANEKYKSALQELEELKQ 731
                                              F  A+VL  ++KYK +     +  +
Sbjct: 621 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIK 680

Query: 732 IVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYL 784
             P  +  +  +  +Y + G   LA  ++  ++ LDP  +  +    + +R L
Sbjct: 681 ANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKL 733



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 50/255 (19%), Positives = 100/255 (39%), Gaps = 28/255 (10%)

Query: 468 EMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFEL----SEYMQAERIFS 523
           ++ +  L++C  N K   NI  +L      T  +     R Y E      +Y+ A     
Sbjct: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAI-----RYYREAVRLNPKYVHAMNNLG 523

Query: 524 EVRRIENYRVEGMEIYSTTLWHLQKDVA-----LSVLSKDLTDMD-------------KN 565
            + +  N   E  E+ S  +  +Q D A     L ++   L   +             + 
Sbjct: 524 NILKERNELQEAEELLSLAV-QIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRK 582

Query: 566 SPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFR 625
            P+ +   G  ++    H  A+  ++ A  + P ++ A+  +      T  L +A A  R
Sbjct: 583 YPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGR 642

Query: 626 NAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 685
            A+ + P  ++  + L  +  K +K+  +E  F KA+  NP ++    ++ V+ H     
Sbjct: 643 EALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHL 702

Query: 686 EKALDTLNKAIVIDP 700
           + A      ++ +DP
Sbjct: 703 DLAKKHYEISLQLDP 717



 Score = 36.6 bits (83), Expect = 0.097
 Identities = 21/97 (21%), Positives = 50/97 (51%)

Query: 591 QRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEK 650
           + A+++ PN       L +    +++  ++ A F  AI+ NP   +    L ++Y++   
Sbjct: 642 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 701

Query: 651 FSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 687
             LA+ H++ +L ++P +S    + G+++  L+  +K
Sbjct: 702 LDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 738


>gi|118766330 transmembrane and tetratricopeptide repeat containing
           4 isoform 1 [Homo sapiens]
          Length = 760

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 38/153 (24%), Positives = 70/153 (45%)

Query: 588 KFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYK 647
           + F+ A+ V P  A  +  +G           A+  +R A+R+NP++ +A   LG I  +
Sbjct: 488 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 547

Query: 648 QEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKF 707
           + +   AE     A+ I P  +    ++G+VQ++LK+ E A  +   AI    K P C +
Sbjct: 548 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYY 607

Query: 708 HRASVLFANEKYKSALQELEELKQIVPKESLVY 740
           +   +     ++  AL        + P+ SL +
Sbjct: 608 NLGRLYADLNRHVDALNAWRNATVLKPEHSLAW 640



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 46/233 (19%), Positives = 95/233 (40%), Gaps = 34/233 (14%)

Query: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 645
           AI++++ A++++P Y +A   LG+      EL +A      A+++ P    AW  LG++ 
Sbjct: 520 AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQ 579

Query: 646 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLC 705
              ++F  AE  ++ A+    +      ++G +   L +   AL+    A V+ P++ L 
Sbjct: 580 NSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLA 639

Query: 706 ----------------------------------KFHRASVLFANEKYKSALQELEELKQ 731
                                              F  A+VL  ++KYK +     +  +
Sbjct: 640 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIK 699

Query: 732 IVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYL 784
             P  +  +  +  +Y + G   LA  ++  ++ LDP  +  +    + +R L
Sbjct: 700 ANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKL 752



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 50/255 (19%), Positives = 100/255 (39%), Gaps = 28/255 (10%)

Query: 468 EMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFEL----SEYMQAERIFS 523
           ++ +  L++C  N K   NI  +L      T  +     R Y E      +Y+ A     
Sbjct: 488 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAI-----RYYREAVRLNPKYVHAMNNLG 542

Query: 524 EVRRIENYRVEGMEIYSTTLWHLQKDVA-----LSVLSKDLTDMD-------------KN 565
            + +  N   E  E+ S  +  +Q D A     L ++   L   +             + 
Sbjct: 543 NILKERNELQEAEELLSLAV-QIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRK 601

Query: 566 SPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFR 625
            P+ +   G  ++    H  A+  ++ A  + P ++ A+  +      T  L +A A  R
Sbjct: 602 YPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGR 661

Query: 626 NAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 685
            A+ + P  ++  + L  +  K +K+  +E  F KA+  NP ++    ++ V+ H     
Sbjct: 662 EALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHL 721

Query: 686 EKALDTLNKAIVIDP 700
           + A      ++ +DP
Sbjct: 722 DLAKKHYEISLQLDP 736



 Score = 36.6 bits (83), Expect = 0.097
 Identities = 21/97 (21%), Positives = 50/97 (51%)

Query: 591 QRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEK 650
           + A+++ PN       L +    +++  ++ A F  AI+ NP   +    L ++Y++   
Sbjct: 661 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 720

Query: 651 FSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 687
             LA+ H++ +L ++P +S    + G+++  L+  +K
Sbjct: 721 LDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 757


>gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo
           sapiens]
          Length = 639

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 36/131 (27%), Positives = 64/131 (48%), Gaps = 3/131 (2%)

Query: 538 IYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVD 597
           + S +L+   K++ L+ +  D T +D   P+  C  G  F+L  E+D A+  F  A+ V 
Sbjct: 462 LLSDSLFLEVKELFLAAVRLDPTSID---PDVQCGLGVLFNLSGEYDKAVDCFTAALSVR 518

Query: 598 PNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMH 657
           PN    +  LG       + ++A+A +R A+ + P +  + Y LG+          A  H
Sbjct: 519 PNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEH 578

Query: 658 FQKALDINPQS 668
           F +AL++  +S
Sbjct: 579 FLEALNMQRKS 589



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 20/77 (25%), Positives = 36/77 (46%)

Query: 616 ELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675
           +L  A+  F  A++ +P+H  AW  LG    + E+  LA    ++ L++ P +   L  +
Sbjct: 350 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 409

Query: 676 GVVQHALKKSEKALDTL 692
            V         +A +TL
Sbjct: 410 AVSFTNESLQRQACETL 426



 Score = 30.4 bits (67), Expect = 7.0
 Identities = 48/249 (19%), Positives = 94/249 (37%), Gaps = 24/249 (9%)

Query: 554 VLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613
           +L +     D    EAW   G   +   +  +AI   +R +++ P+   A   L   F  
Sbjct: 356 LLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTN 415

Query: 614 TEELDKALACFRNAIRVNPRHYN-----------AWYG-----LGMIYYKQEKFSLAEMH 657
                +A    R+ +R  P + +           A  G     LG +        + E+ 
Sbjct: 416 ESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKEL- 474

Query: 658 FQKALDINPQS--SVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFA 715
           F  A+ ++P S    + C +GV+ +   + +KA+D    A+ + P + L      + L  
Sbjct: 475 FLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLAN 534

Query: 716 NEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLD-----PKG 770
             + + A+       ++ P      + +G     LG    A+ +F  A+++      P+G
Sbjct: 535 GNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRG 594

Query: 771 ANNQIKEAI 779
               + E I
Sbjct: 595 EGGAMSENI 603


>gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo
           sapiens]
          Length = 639

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 36/131 (27%), Positives = 64/131 (48%), Gaps = 3/131 (2%)

Query: 538 IYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVD 597
           + S +L+   K++ L+ +  D T +D   P+  C  G  F+L  E+D A+  F  A+ V 
Sbjct: 462 LLSDSLFLEVKELFLAAVRLDPTSID---PDVQCGLGVLFNLSGEYDKAVDCFTAALSVR 518

Query: 598 PNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMH 657
           PN    +  LG       + ++A+A +R A+ + P +  + Y LG+          A  H
Sbjct: 519 PNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEH 578

Query: 658 FQKALDINPQS 668
           F +AL++  +S
Sbjct: 579 FLEALNMQRKS 589



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 20/77 (25%), Positives = 36/77 (46%)

Query: 616 ELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675
           +L  A+  F  A++ +P+H  AW  LG    + E+  LA    ++ L++ P +   L  +
Sbjct: 350 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 409

Query: 676 GVVQHALKKSEKALDTL 692
            V         +A +TL
Sbjct: 410 AVSFTNESLQRQACETL 426



 Score = 30.4 bits (67), Expect = 7.0
 Identities = 48/249 (19%), Positives = 94/249 (37%), Gaps = 24/249 (9%)

Query: 554 VLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613
           +L +     D    EAW   G   +   +  +AI   +R +++ P+   A   L   F  
Sbjct: 356 LLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTN 415

Query: 614 TEELDKALACFRNAIRVNPRHYN-----------AWYG-----LGMIYYKQEKFSLAEMH 657
                +A    R+ +R  P + +           A  G     LG +        + E+ 
Sbjct: 416 ESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKEL- 474

Query: 658 FQKALDINPQS--SVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFA 715
           F  A+ ++P S    + C +GV+ +   + +KA+D    A+ + P + L      + L  
Sbjct: 475 FLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLAN 534

Query: 716 NEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLD-----PKG 770
             + + A+       ++ P      + +G     LG    A+ +F  A+++      P+G
Sbjct: 535 GNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRG 594

Query: 771 ANNQIKEAI 779
               + E I
Sbjct: 595 EGGAMSENI 603


>gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo
           sapiens]
          Length = 602

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 36/131 (27%), Positives = 64/131 (48%), Gaps = 3/131 (2%)

Query: 538 IYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVD 597
           + S +L+   K++ L+ +  D T +D   P+  C  G  F+L  E+D A+  F  A+ V 
Sbjct: 425 LLSDSLFLEVKELFLAAVRLDPTSID---PDVQCGLGVLFNLSGEYDKAVDCFTAALSVR 481

Query: 598 PNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMH 657
           PN    +  LG       + ++A+A +R A+ + P +  + Y LG+          A  H
Sbjct: 482 PNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEH 541

Query: 658 FQKALDINPQS 668
           F +AL++  +S
Sbjct: 542 FLEALNMQRKS 552



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 20/77 (25%), Positives = 36/77 (46%)

Query: 616 ELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675
           +L  A+  F  A++ +P+H  AW  LG    + E+  LA    ++ L++ P +   L  +
Sbjct: 313 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 372

Query: 676 GVVQHALKKSEKALDTL 692
            V         +A +TL
Sbjct: 373 AVSFTNESLQRQACETL 389



 Score = 30.4 bits (67), Expect = 7.0
 Identities = 48/249 (19%), Positives = 94/249 (37%), Gaps = 24/249 (9%)

Query: 554 VLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613
           +L +     D    EAW   G   +   +  +AI   +R +++ P+   A   L   F  
Sbjct: 319 LLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTN 378

Query: 614 TEELDKALACFRNAIRVNPRHYN-----------AWYG-----LGMIYYKQEKFSLAEMH 657
                +A    R+ +R  P + +           A  G     LG +        + E+ 
Sbjct: 379 ESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKEL- 437

Query: 658 FQKALDINPQS--SVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFA 715
           F  A+ ++P S    + C +GV+ +   + +KA+D    A+ + P + L      + L  
Sbjct: 438 FLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLAN 497

Query: 716 NEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLD-----PKG 770
             + + A+       ++ P      + +G     LG    A+ +F  A+++      P+G
Sbjct: 498 GNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRG 557

Query: 771 ANNQIKEAI 779
               + E I
Sbjct: 558 EGGAMSENI 566


>gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo
           sapiens]
          Length = 654

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 36/131 (27%), Positives = 64/131 (48%), Gaps = 3/131 (2%)

Query: 538 IYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVD 597
           + S +L+   K++ L+ +  D T +D   P+  C  G  F+L  E+D A+  F  A+ V 
Sbjct: 477 LLSDSLFLEVKELFLAAVRLDPTSID---PDVQCGLGVLFNLSGEYDKAVDCFTAALSVR 533

Query: 598 PNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMH 657
           PN    +  LG       + ++A+A +R A+ + P +  + Y LG+          A  H
Sbjct: 534 PNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEH 593

Query: 658 FQKALDINPQS 668
           F +AL++  +S
Sbjct: 594 FLEALNMQRKS 604



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 20/77 (25%), Positives = 36/77 (46%)

Query: 616 ELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675
           +L  A+  F  A++ +P+H  AW  LG    + E+  LA    ++ L++ P +   L  +
Sbjct: 365 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 424

Query: 676 GVVQHALKKSEKALDTL 692
            V         +A +TL
Sbjct: 425 AVSFTNESLQRQACETL 441



 Score = 30.4 bits (67), Expect = 7.0
 Identities = 48/249 (19%), Positives = 94/249 (37%), Gaps = 24/249 (9%)

Query: 554 VLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613
           +L +     D    EAW   G   +   +  +AI   +R +++ P+   A   L   F  
Sbjct: 371 LLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTN 430

Query: 614 TEELDKALACFRNAIRVNPRHYN-----------AWYG-----LGMIYYKQEKFSLAEMH 657
                +A    R+ +R  P + +           A  G     LG +        + E+ 
Sbjct: 431 ESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKEL- 489

Query: 658 FQKALDINPQS--SVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFA 715
           F  A+ ++P S    + C +GV+ +   + +KA+D    A+ + P + L      + L  
Sbjct: 490 FLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLAN 549

Query: 716 NEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLD-----PKG 770
             + + A+       ++ P      + +G     LG    A+ +F  A+++      P+G
Sbjct: 550 GNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRG 609

Query: 771 ANNQIKEAI 779
               + E I
Sbjct: 610 EGGAMSENI 618


>gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo
           sapiens]
          Length = 631

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 36/131 (27%), Positives = 64/131 (48%), Gaps = 3/131 (2%)

Query: 538 IYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVD 597
           + S +L+   K++ L+ +  D T +D   P+  C  G  F+L  E+D A+  F  A+ V 
Sbjct: 454 LLSDSLFLEVKELFLAAVRLDPTSID---PDVQCGLGVLFNLSGEYDKAVDCFTAALSVR 510

Query: 598 PNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMH 657
           PN    +  LG       + ++A+A +R A+ + P +  + Y LG+          A  H
Sbjct: 511 PNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEH 570

Query: 658 FQKALDINPQS 668
           F +AL++  +S
Sbjct: 571 FLEALNMQRKS 581



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 20/77 (25%), Positives = 36/77 (46%)

Query: 616 ELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675
           +L  A+  F  A++ +P+H  AW  LG    + E+  LA    ++ L++ P +   L  +
Sbjct: 342 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 401

Query: 676 GVVQHALKKSEKALDTL 692
            V         +A +TL
Sbjct: 402 AVSFTNESLQRQACETL 418



 Score = 30.4 bits (67), Expect = 7.0
 Identities = 48/249 (19%), Positives = 94/249 (37%), Gaps = 24/249 (9%)

Query: 554 VLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613
           +L +     D    EAW   G   +   +  +AI   +R +++ P+   A   L   F  
Sbjct: 348 LLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTN 407

Query: 614 TEELDKALACFRNAIRVNPRHYN-----------AWYG-----LGMIYYKQEKFSLAEMH 657
                +A    R+ +R  P + +           A  G     LG +        + E+ 
Sbjct: 408 ESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKEL- 466

Query: 658 FQKALDINPQS--SVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFA 715
           F  A+ ++P S    + C +GV+ +   + +KA+D    A+ + P + L      + L  
Sbjct: 467 FLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLAN 526

Query: 716 NEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLD-----PKG 770
             + + A+       ++ P      + +G     LG    A+ +F  A+++      P+G
Sbjct: 527 GNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRG 586

Query: 771 ANNQIKEAI 779
               + E I
Sbjct: 587 EGGAMSENI 595


>gi|224809432 transmembrane and tetratricopeptide repeat containing
           3 [Homo sapiens]
          Length = 914

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 41/156 (26%), Positives = 77/156 (49%), Gaps = 4/156 (2%)

Query: 593 AIQVDPNYAYAYTLLGHEFVLTEE-LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKF 651
           A ++ PN+   Y  L +     E  L++A   +R AI + P    A+   G +  K  K 
Sbjct: 520 AARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKP 579

Query: 652 SLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRAS 711
             A+  + KAL+++  ++ L  ++ +V   LK+  +AL   N+A+ ++PK+ L  F+ A 
Sbjct: 580 LKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639

Query: 712 VLFANEKYKSALQELEELKQIVPKESL---VYFLIG 744
           V+  + + K   +  + L   + +E L    YF +G
Sbjct: 640 VMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLG 675



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 57/275 (20%), Positives = 115/275 (41%), Gaps = 28/275 (10%)

Query: 544 WHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYA 603
           W  +  + +S L      ++KN+ + W   G+    ++  + A+K+F +A  V P+   A
Sbjct: 428 WESEYTLFMSALK-----VNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGA 482

Query: 604 YTLLGHEFV---LTEELDKALACFRN-----------AIRVNPRHYNAWYGL-GMIYYKQ 648
           +  +G  +     T+E +++    ++           A R+ P H N +  L  +I   +
Sbjct: 483 HMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE 542

Query: 649 EKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFH 708
            +   A+  +++A+ + P         G +   + K  KA +   KA+ +D  N    ++
Sbjct: 543 SRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYN 602

Query: 709 RASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHL------ALMNFSW 762
            A V    ++   AL+      ++ PK  L  F    V ++ G+  L       L+++  
Sbjct: 603 LAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYIN 662

Query: 763 AMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQI 797
              LD  G  N    A+D +   D+E  I  ++ I
Sbjct: 663 EEPLDANGYFNLGMLAMDDK--KDNEAEIWMKKAI 695



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 32/141 (22%), Positives = 64/141 (45%), Gaps = 7/141 (4%)

Query: 561 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD-- 618
           ++D+N+ + W          +E + A+K F RA++++P +  A  L     V+ E  +  
Sbjct: 591 ELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLA--LFNSAIVMQESGEVK 648

Query: 619 ---KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675
              +A     + I   P   N ++ LGM+    +K + AE+  +KA+ +       L ++
Sbjct: 649 LRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708

Query: 676 GVVQHALKKSEKALDTLNKAI 696
            ++     K  KAL  L + +
Sbjct: 709 ALLYSQTAKELKALPILEELL 729



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 44/227 (19%), Positives = 86/227 (37%), Gaps = 38/227 (16%)

Query: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 645
           A + +++AI + P++  AY   G   +   +  KA   +  A+ ++  + + WY L +++
Sbjct: 548 ADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVH 607

Query: 646 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHAL----------------------- 682
            + ++ + A  +F +AL++NP+  + L +  +V                           
Sbjct: 608 IELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLD 667

Query: 683 --------------KKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEE 728
                         KK  +A   + KAI +        F+ A +     K   AL  LEE
Sbjct: 668 ANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEE 727

Query: 729 LKQIVPKESLVYFLIGKVYKKLGQTHL-ALMNFSWAMDLDPKGANNQ 774
           L +  P       L G +     +  L A   F   +++DP     +
Sbjct: 728 LLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGK 774



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 18/102 (17%), Positives = 47/102 (46%), Gaps = 3/102 (2%)

Query: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD--KALACFRNAIRVNPRHYNAWYGLGM 643
           A+   +  ++  P++     L G + ++ ++ D   A  CF   + ++P +    + L +
Sbjct: 721 ALPILEELLRYYPDHIKGLILKG-DILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCV 779

Query: 644 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 685
           +Y++++    AE    + L + P    +  H+ +V+  +  S
Sbjct: 780 VYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSS 821


>gi|212549738 anaphase-promoting complex subunit 7 isoform b [Homo
           sapiens]
          Length = 537

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 50/226 (22%), Positives = 92/226 (40%), Gaps = 5/226 (2%)

Query: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT 560
           +L  +   YF   +   +   F + + ++ Y ++GM++Y   L    +   +  L   L 
Sbjct: 273 LLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLF 332

Query: 561 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKA 620
           ++     E W  +G      + +  A+    +AIQ++ N   A  L G        + +A
Sbjct: 333 NISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEA 392

Query: 621 LACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEM---HFQKALDINPQSSVLLCHIGV 677
           +  FR AIR+ P   + + GL   Y        A +   +  K L  N Q+  LL  + +
Sbjct: 393 IIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCL 452

Query: 678 VQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSAL 723
                +  EKA   L+KA+   P        +A +L   +KY+  +
Sbjct: 453 EDPVTQ--EKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGI 496


>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
           sapiens]
          Length = 860

 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 57/251 (22%), Positives = 104/251 (41%), Gaps = 18/251 (7%)

Query: 468 EMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFE--LSEYMQAERIFSEV 525
           E+   Y+ + S    EAI   S +     +    +   G AY +  L +   AE    E+
Sbjct: 146 ELAIAYVLIGSGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFEL 205

Query: 526 RRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEA--WCAAGNCFSLQREH 583
            R+     +  E++      L     ++    DLT   +  P A  +   G  + +  ++
Sbjct: 206 SRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDY 265

Query: 584 DIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGM 643
             A + FQ++++++ N   A    G  F     L +A+  F+ A++      +A+  LG 
Sbjct: 266 ATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQ 325

Query: 644 IYYKQEKFSLAEMHFQKALDINPQ-------SSVLLCHIGVVQHALKKSEKALDTLNKAI 696
            Y +   F  A   FQKAL +N           ++L H G +Q ALK  ++ L       
Sbjct: 326 AYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQ------ 379

Query: 697 VIDPKNPLCKF 707
            ++P N +C++
Sbjct: 380 -LEPYNEVCQY 389



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 47/236 (19%), Positives = 99/236 (41%), Gaps = 2/236 (0%)

Query: 549 DVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLG 608
           ++AL  LS+ +T ++ + PE +       S     + A+    +AIQ+ P+ A  Y   G
Sbjct: 199 ELALFELSRVIT-LEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRG 256

Query: 609 HEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQS 668
             + ++E+   A   F+ ++ +N     A    G+ ++ +     A   F++AL      
Sbjct: 257 TLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDF 316

Query: 669 SVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEE 728
                 +G     L   E A ++  KA++++  +      R  +L+ +   + AL+  + 
Sbjct: 317 IDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKR 376

Query: 729 LKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYL 784
             Q+ P   +  ++ G  +  +GQ +  +   +  M  DP        E +  +YL
Sbjct: 377 CLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYL 432


>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
           sapiens]
          Length = 807

 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 45/183 (24%), Positives = 81/183 (44%), Gaps = 16/183 (8%)

Query: 534 EGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEA--WCAAGNCFSLQREHDIAIKFFQ 591
           E +  +ST L  L     ++    DLT   +  P A  +   G  + +  ++  A + FQ
Sbjct: 161 EAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQ 220

Query: 592 RAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKF 651
           ++++++ N   A    G  F     L +A+  F+ A++      +A+  LG  Y +   F
Sbjct: 221 QSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNF 280

Query: 652 SLAEMHFQKALDINPQ-------SSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL 704
             A   FQKAL +N           ++L H G +Q ALK  ++ L        ++P N +
Sbjct: 281 EAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQ-------LEPYNEV 333

Query: 705 CKF 707
           C++
Sbjct: 334 CQY 336



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 39/199 (19%), Positives = 82/199 (41%), Gaps = 1/199 (0%)

Query: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 645
           A+    +AIQ+ P+ A  Y   G  + ++E+   A   F+ ++ +N     A    G+ +
Sbjct: 182 AVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTF 240

Query: 646 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLC 705
           + +     A   F++AL            +G     L   E A ++  KA++++  +   
Sbjct: 241 FHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQT 300

Query: 706 KFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMD 765
              R  +L+ +   + AL+  +   Q+ P   +  ++ G  +  +GQ +  +   +  M 
Sbjct: 301 LQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVML 360

Query: 766 LDPKGANNQIKEAIDKRYL 784
            DP        E +  +YL
Sbjct: 361 NDPLPGQKASPEYLKVKYL 379


>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
           sapiens]
          Length = 515

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 5/170 (2%)

Query: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGME-IYSTTLWHLQKDVALSVLSKDL 559
           +LC I R Y E++    A   + EV + +N  VE +  I S   +  Q ++AL    + L
Sbjct: 294 LLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRR-L 352

Query: 560 TDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTL---LGHEFVLTEE 616
             M   + + +   G C    +++D+ +  F+RA+ +  N   A  +   LGH  V   +
Sbjct: 353 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 412

Query: 617 LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP 666
            + A  CFR A+  N  H  A+  L ++  ++     A    Q A  + P
Sbjct: 413 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 462



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 33/184 (17%), Positives = 74/184 (40%), Gaps = 2/184 (1%)

Query: 482 KEAINILSHLPSH-HYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS 540
           K A+++ +    H  Y   W   QIG+ Y+ L  Y +AE+ F    + +   V+     +
Sbjct: 207 KTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLA 265

Query: 541 TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY 600
                L + V    L K   D         C     +        A ++++  ++ D  +
Sbjct: 266 KVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTH 325

Query: 601 AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK 660
             A   +G     +++ + AL  +R  +++   +   +  LG+  +  +++ +    F++
Sbjct: 326 VEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFER 385

Query: 661 ALDI 664
           AL +
Sbjct: 386 ALSL 389


>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
           sapiens]
          Length = 475

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 5/170 (2%)

Query: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGME-IYSTTLWHLQKDVALSVLSKDL 559
           +LC I R Y E++    A   + EV + +N  VE +  I S   +  Q ++AL    + L
Sbjct: 254 LLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRR-L 312

Query: 560 TDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTL---LGHEFVLTEE 616
             M   + + +   G C    +++D+ +  F+RA+ +  N   A  +   LGH  V   +
Sbjct: 313 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 372

Query: 617 LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP 666
            + A  CFR A+  N  H  A+  L ++  ++     A    Q A  + P
Sbjct: 373 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 422



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 33/184 (17%), Positives = 74/184 (40%), Gaps = 2/184 (1%)

Query: 482 KEAINILSHLPSH-HYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS 540
           K A+++ +    H  Y   W   QIG+ Y+ L  Y +AE+ F    + +   V+     +
Sbjct: 167 KTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLA 225

Query: 541 TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY 600
                L + V    L K   D         C     +        A ++++  ++ D  +
Sbjct: 226 KVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTH 285

Query: 601 AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK 660
             A   +G     +++ + AL  +R  +++   +   +  LG+  +  +++ +    F++
Sbjct: 286 VEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFER 345

Query: 661 ALDI 664
           AL +
Sbjct: 346 ALSL 349


>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
           sapiens]
          Length = 505

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 5/170 (2%)

Query: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGME-IYSTTLWHLQKDVALSVLSKDL 559
           +LC I R Y E++    A   + EV + +N  VE +  I S   +  Q ++AL    + L
Sbjct: 284 LLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRR-L 342

Query: 560 TDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTL---LGHEFVLTEE 616
             M   + + +   G C    +++D+ +  F+RA+ +  N   A  +   LGH  V   +
Sbjct: 343 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 402

Query: 617 LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP 666
            + A  CFR A+  N  H  A+  L ++  ++     A    Q A  + P
Sbjct: 403 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 452



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 33/184 (17%), Positives = 74/184 (40%), Gaps = 2/184 (1%)

Query: 482 KEAINILSHLPSH-HYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS 540
           K A+++ +    H  Y   W   QIG+ Y+ L  Y +AE+ F    + +   V+     +
Sbjct: 197 KTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLA 255

Query: 541 TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY 600
                L + V    L K   D         C     +        A ++++  ++ D  +
Sbjct: 256 KVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTH 315

Query: 601 AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK 660
             A   +G     +++ + AL  +R  +++   +   +  LG+  +  +++ +    F++
Sbjct: 316 VEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFER 375

Query: 661 ALDI 664
           AL +
Sbjct: 376 ALSL 379


>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
           A [Homo sapiens]
          Length = 608

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 56/254 (22%), Positives = 113/254 (44%), Gaps = 27/254 (10%)

Query: 581 REHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYG 640
           +E D   K+   A+ +   +   Y L+G+      +LDK ++     +++     NA   
Sbjct: 319 KEIDAEGKYMAEALLLRATF---YLLIGNANAAKPDLDKVISLKEANVKLRA---NALIK 372

Query: 641 LGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDP 700
            G +Y +Q++  L+   F  A DI+PQ++ +  H G ++  L + E+A+   ++ I + P
Sbjct: 373 RGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRP 432

Query: 701 KNPLCKFHRASVLFA-------NEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQT 753
           ++ L +  +   L+        + + ++A++  EE+ +  P+ +  Y L  +      Q 
Sbjct: 433 ESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQF 492

Query: 754 HLALMNFSWAMDLDPKGANNQIKEAI----DKRYLPDDEEPITQEEQI----------MG 799
             A   +   +DL+P  A   + + +     K+ L    E I++  +I          MG
Sbjct: 493 GKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMG 552

Query: 800 TDESQESSMTDADD 813
           T E Q  +M  A D
Sbjct: 553 TIEVQRGNMEKAID 566



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 39/165 (23%), Positives = 67/165 (40%), Gaps = 16/165 (9%)

Query: 547 QKDVALSVLSKDLTDMDK----NSPEAWCAAGNCFSLQREH---------DIAIKFFQRA 593
           Q  + L  + + + D D+        A   A  CF+L R+            A+K F+  
Sbjct: 409 QLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEV 468

Query: 594 IQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWY--GLGMIYYKQEKF 651
           I+  P  A  Y L        ++  KA   +   I + P +   +   GL  + +KQ+  
Sbjct: 469 IKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLD 528

Query: 652 SLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 696
              E+   KA++I+ +       +G ++      EKA+D  NKAI
Sbjct: 529 RGLEL-ISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAI 572



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 27/120 (22%), Positives = 52/120 (43%), Gaps = 3/120 (2%)

Query: 513 SEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCA 572
           S+   A + F EV +      EG  +Y+  L   Q+      +     D++ ++   +  
Sbjct: 456 SQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVH 515

Query: 573 AGNCFSLQREHDI--AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRV 630
            G    LQ + D+   ++   +AI++D    +AY  +G   V    ++KA+  F  AI +
Sbjct: 516 KG-LLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINL 574


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,917,031
Number of Sequences: 37866
Number of extensions: 1521477
Number of successful extensions: 7049
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 88
Number of HSP's successfully gapped in prelim test: 198
Number of HSP's that attempted gapping in prelim test: 5691
Number of HSP's gapped (non-prelim): 1048
length of query: 824
length of database: 18,247,518
effective HSP length: 111
effective length of query: 713
effective length of database: 14,044,392
effective search space: 10013651496
effective search space used: 10013651496
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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