Search of human proteins with 166362724

Search of human proteins with 166362724

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|166362724 cytochrome P450, family 8, subfamily B,
polypeptide 1 [Homo sapiens]
         (501 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|166362724 cytochrome P450, family 8, subfamily B, polypeptide...  1038   0.0  
gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo sapiens]   376   e-104
gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide...   302   4e-82
gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1...   275   7e-74
gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide...   135   9e-32
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...    70   3e-12
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ...    69   1e-11
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...    67   4e-11
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...    67   5e-11
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...    67   5e-11
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...    65   2e-10
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...    62   2e-09
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ...    61   3e-09
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...    61   3e-09
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                   60   4e-09
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...    59   8e-09
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...    59   8e-09
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...    59   1e-08
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...    59   1e-08
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...    57   5e-08
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...    55   1e-07
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...    55   1e-07
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...    55   1e-07
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...    55   1e-07
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...    55   2e-07
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...    55   2e-07
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...    54   4e-07
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...    53   7e-07
gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide...    52   1e-06
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...    51   3e-06

>gi|166362724 cytochrome P450, family 8, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score = 1038 bits (2684), Expect = 0.0
 Identities = 501/501 (100%), Positives = 501/501 (100%)

Query: 1   MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRM 60
           MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRM
Sbjct: 1   MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRM 60

Query: 61  RTKHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH 120
           RTKHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH
Sbjct: 61  RTKHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH 120

Query: 121 EMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTA 180
           EMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTA
Sbjct: 121 EMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTA 180

Query: 181 GYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHKML 240
           GYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHKML
Sbjct: 181 GYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHKML 240

Query: 241 SVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLK 300
           SVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLK
Sbjct: 241 SVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLK 300

Query: 301 HPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLV 360
           HPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLV
Sbjct: 301 HPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLV 360

Query: 361 HEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFF 420
           HEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFF
Sbjct: 361 HEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFF 420

Query: 421 KTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRW 480
           KTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRW
Sbjct: 421 KTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRW 480

Query: 481 GFGTMQPSHDVRFRYRLHPTE 501
           GFGTMQPSHDVRFRYRLHPTE
Sbjct: 481 GFGTMQPSHDVRFRYRLHPTE 501


>gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo sapiens]
          Length = 500

 Score =  376 bits (965), Expect = e-104
 Identities = 204/503 (40%), Positives = 295/503 (58%), Gaps = 12/503 (2%)

Query: 4   WGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRMRTK 63
           W  +LG L  ++   L L    R RRP EPPLD G++PWLG+A+ F K+   FL RM+ K
Sbjct: 3   WAALLGLLAALLL--LLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK 60

Query: 64  HGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDHEMI 123
           HGD+FT+ +GG+Y T ++DP S+ +++ + + +LDF  YA  L+ ++F  +         
Sbjct: 61  HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE 120

Query: 124 HSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDA-SCWHEDSLFRFCYYILFTAGY 182
            +     L    L+ L E M  +L  V+L   G + +A S WHE  L  F Y  L  AGY
Sbjct: 121 KARMKLTLLHRELQALTEAMYTNLHAVLL---GDATEAGSGWHEMGLLDFSYSFLLRAGY 177

Query: 183 LSLFGYT------KDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLF 236
           L+L+G        + + QD + + ++F  FR+ D L P+     L   +   +  ++   
Sbjct: 178 LTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRL 237

Query: 237 HKMLSVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALL 296
            K+LS +    +   S WL + L  L E GV   MQ +   + LWA+QGN GP +FW LL
Sbjct: 238 WKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLL 297

Query: 297 YLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTL 356
           +LLK+PEA+ AVR E   +L +A     Q+       L  TPVLDSV+ E+LRL AAP +
Sbjct: 298 FLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFI 357

Query: 357 LRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRK 416
            R V  D  + M+ G+E+  R GD L LFP+LS   DP+I+ +P VFKY+RFLNP+GS K
Sbjct: 358 TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEK 417

Query: 417 VDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVD 476
            DF+K GK++ +Y MPWG+G + C GR +A++ +K F+ L++ H DLEL++ D  +P  D
Sbjct: 418 KDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFD 477

Query: 477 PQRWGFGTMQPSHDVRFRYRLHP 499
             R+GFG MQP HDV  RYR+ P
Sbjct: 478 LSRYGFGLMQPEHDVPVRYRIRP 500


>gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  302 bits (774), Expect = 4e-82
 Identities = 180/511 (35%), Positives = 285/511 (55%), Gaps = 32/511 (6%)

Query: 2   VLWGPVLGALLVVIAGYLCLPGML--RQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKR 59
           ++WG       + IA   CL  +L  R+R+  EPPL+ G +P+LG A+ F  N  EFL+ 
Sbjct: 6   LIWG-------IAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRA 58

Query: 60  MRTKHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQ-- 117
            + KHG VFT +L G+Y  F+ +PLS+  +L    +  D+ ++      K FG+RS+   
Sbjct: 59  NQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHG-KYFDWKKFHFATSAKAFGHRSIDPM 117

Query: 118 --GDHEMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYY 175
                E I+    K L+G  L  L E+M+++L  +M      +   + W  + ++ FCY 
Sbjct: 118 DGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYR 177

Query: 176 ILFTAGYLSLFGYTKDKEQDLLQAGEL--FMEFRKFDLLFPRFVYSLLWPREWLEVGRLQ 233
           ++F AGYL++FG    + +D  +A  L     F++FD +FP  V  L  P          
Sbjct: 178 VMFEAGYLTIFGRDLTR-RDTQKAHILNNLDNFKQFDKVFPALVAGL--PIHMFRTAHNA 234

Query: 234 R-LFHKMLSVSHSQEKEGISNWLGNMLQFLREQGVPSAMQD----KFNFMMLWASQGNTG 288
           R    + L   + Q++E IS  + ++  FL +    S   D    K + ++LWASQ NT 
Sbjct: 235 REKLAESLRHENLQKRESISELI-SLRMFLND--TLSTFDDLEKAKTHLVVLWASQANTI 291

Query: 289 PTSFWALLYLLKHPEAIRAVREEATQVLGEARLETK---QSFAFKLGALQHTPVLDSVVE 345
           P +FW+L  ++++PEA++A  EE  + L  A  +              L   PVLDS+++
Sbjct: 292 PATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIK 351

Query: 346 ETLRLRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKY 405
           E+LRL +A   +R   ED+TL +  G  Y  R  DI+AL+P L +H+DP+I+P+P  FKY
Sbjct: 352 ESLRLSSASLNIRTAKEDFTLHLEDGS-YNIRKDDIIALYPQL-MHLDPEIYPDPLTFKY 409

Query: 406 DRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLEL 465
           DR+L+ NG  K  F+  G K+ +Y MP+GSG +ICPGR FA+ E+K F++LM+++F+LEL
Sbjct: 410 DRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELEL 469

Query: 466 VDPDTPLPHVDPQRWGFGTMQPSHDVRFRYR 496
           ++     P +D  R G G + P +D+ F+Y+
Sbjct: 470 IEGQAKCPPLDQSRAGLGILPPLNDIEFKYK 500


>gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 506

 Score =  275 bits (703), Expect = 7e-74
 Identities = 181/502 (36%), Positives = 280/502 (55%), Gaps = 27/502 (5%)

Query: 5   GPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRMRTKH 64
           G  L A L+++A  LCL  + R RRP EPPL KG +P+LG  +  RK+   F+K ++ +H
Sbjct: 21  GLALAAALLLLA--LCLL-VRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQH 77

Query: 65  GDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDHEM-- 122
           GD FTV LGG+Y TF++DP  +  ++K+  ++L F  ++ KL+ K F    +Q +H+M  
Sbjct: 78  GDTFTVLLGGKYITFILDPFQYQLVIKN-HKQLSFRVFSNKLLEKAFSISQLQKNHDMND 136

Query: 123 -IHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTAG 181
            +H    + L+G  L  L E+M+ +L  V    +   L  + W    L+ FC  I+F   
Sbjct: 137 ELH-LCYQFLQGKSLDILLESMMQNLKQVF---EPQLLKTTSWDTAELYPFCSSIIFEIT 192

Query: 182 YLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHKMLS 241
           + +++G     + +     EL  +F KFD  F   V ++  P E L  G ++ +  K++ 
Sbjct: 193 FTTIYGKVIVCDNNKF-ISELRDDFLKFDDKFAYLVSNI--PIELL--GNVKSIREKIIK 247

Query: 242 VSHSQEKEGISNW---LGNMLQFLREQGVPSAMQ-DKFNFMMLWASQGNTGPTSFWALLY 297
              S++   +  W     +    L +  V   ++    +   LWAS  NT PT FWA+ Y
Sbjct: 248 CFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYY 307

Query: 298 LLKHPEAIRAVREEATQVLGEARLETKQSFAFKL--GALQHTPVLDSVVEETLRLRAAPT 355
           LL+HPEA+ AVR+E  ++L     +    F   L    L     L+S + E LRL +  T
Sbjct: 308 LLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSYST 367

Query: 356 LLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSR 415
            +R V ED TL   +G +Y  R GD++A+FP + +H DP+I   P  F+YDRF+  +G +
Sbjct: 368 TIRFVEEDLTLSSETG-DYCVRKGDLVAIFPPV-LHGDPEIFEAPEEFRYDRFIE-DGKK 424

Query: 416 KVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHV 475
           K  FFK GKK+  Y MP+G+G S CPGRFFAL E+K  +++++T+FDLE++D D P+  +
Sbjct: 425 KTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIID-DKPI-GL 482

Query: 476 DPQRWGFGTMQPSHDVRFRYRL 497
           +  R  FG   P  DV FRY++
Sbjct: 483 NYSRLLFGIQYPDSDVLFRYKV 504


>gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 469

 Score =  135 bits (340), Expect = 9e-32
 Identities = 127/498 (25%), Positives = 216/498 (43%), Gaps = 42/498 (8%)

Query: 7   VLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRMRTKHGD 66
           ++   +++I G L L  +L+++    PP  KG +PW+G    F K   EF+++ R K+G 
Sbjct: 3   LISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGP 62

Query: 67  VFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRS--VQGDHEMIH 124
           +FTV   G   TFV +       LK   +K+DF    + +V +            HE ++
Sbjct: 63  IFTVFAMGNRMTFVTEEEGINVFLKS--KKVDFELAVQNIVYRTASIPKNVFLALHEKLY 120

Query: 125 SASTKHLRGDGLKDLNETMLDSLSFVM--LTSKGWSLDASCWHEDSLFRFCYYILFTAGY 182
                 +    L      + + L   +  L + G ++D +      L+     +LF    
Sbjct: 121 IMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHG-TMDLNNLVRHLLYPVTVNMLFNK-- 177

Query: 183 LSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGR-LQRLFHKML- 240
            SLF   K K ++  Q  +++ E  ++    P  +      R W +  +    LF K + 
Sbjct: 178 -SLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLL-----RNWSKSKKWFLELFEKNIP 231

Query: 241 SVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLK 300
            +   +  +  S  L      + E          +  ++LWAS  N  P +FW L Y+L 
Sbjct: 232 DIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLS 291

Query: 301 HPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLV 360
           HP+  +A+ E  + V G+A    K         L++  ++   V ET+RL+A   + R V
Sbjct: 292 HPDIHKAIMEGISSVFGKA---GKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKV 348

Query: 361 HEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRK--VD 418
                +K      Y+   GD+L L P+  +H +P   PEP +FK +R+   N  +   +D
Sbjct: 349 -----VKPVEILNYIIPSGDLLMLSPFW-LHRNPKYFPEPELFKPERWKKANLEKHSFLD 402

Query: 419 FFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQ 478
            F          M +GSG   CP R+FAL EV++ I+L++  +D  L+DP     ++   
Sbjct: 403 CF----------MAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHL- 451

Query: 479 RWGFGTMQPSHDVRFRYR 496
               G  QP    R  Y+
Sbjct: 452 ---VGVPQPEGQCRIEYK 466


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 29/215 (13%)

Query: 279 MLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTP 338
           + +A    T  T  + LL L+K+PE    + EE  +V+G +R+         +   Q  P
Sbjct: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA-------IKDRQEMP 348

Query: 339 VLDSVVEETLR-LRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYL-SVHMDPDI 396
            +D+VV E  R +   P+   L HE     +  G  YL   G ++   P L SV  D   
Sbjct: 349 YMDAVVHEIQRFITLVPS--NLPHEATRDTIFRG--YLIPKGTVVV--PTLDSVLYDNQE 402

Query: 397 HPEPTVFKYDRFLNPNGSRKV-DFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFIL 455
            P+P  FK + FLN NG  K  D+FK          P+ +G  +C G   A  E+ L + 
Sbjct: 403 FPDPEKFKPEHFLNENGKFKYSDYFK----------PFSTGKRVCAGEGLARMELFLLLC 452

Query: 456 LMVTHFDLE-LVDPDTPLPHVDPQRWGFGTMQPSH 489
            ++ HF+L+ LVDP      + P   GFG + P +
Sbjct: 453 AILQHFNLKPLVDPKD--IDLSPIHIGFGCIPPRY 485



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 2/66 (3%)

Query: 12 LVVIAGYLCLPGMLRQ-RRPWEPPLDKGTVPWLGHAMAFR-KNMFEFLKRMRTKHGDVFT 69
          L+V A +L L  M RQ    W  P     +P +G+      KN+ +   R+  + G VFT
Sbjct: 10 LLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFT 69

Query: 70 VQLGGQ 75
          + +G Q
Sbjct: 70 LYVGSQ 75


>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 1 [Homo sapiens]
          Length = 509

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 103/464 (22%), Positives = 190/464 (40%), Gaps = 37/464 (7%)

Query: 11  LLVVIAGYLC-LPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRMRTKHGDVFT 69
           L+ + AG+L  LP  ++      PP     +P+LGHA+AF K+  EFL+    K+G VF+
Sbjct: 49  LIRLAAGHLVQLPAGVKS-----PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFS 103

Query: 70  VQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDHEMIHSASTK 129
             + G+ FT+++   +   +       L+      +L   VFG + V  D         K
Sbjct: 104 FTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG-KGVAYDVPNPVFLEQK 162

Query: 130 HLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTAGYLSLFGYT 189
            +   GL   +      +S +   +K +        E ++F     ++       L G  
Sbjct: 163 KMLKSGLNIAH--FKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHG-K 219

Query: 190 KDKEQDLLQAGELFME----FRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHKMLSVSHS 245
           + + Q   +  +L+ +    F     L P ++    + R       ++ +F+K +     
Sbjct: 220 EIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQ-KRR 278

Query: 246 QEKEGISNWLGNMLQFLREQGVPSAMQDKFNFM--MLWASQGNTGPTSFWALLYLLKHPE 303
           Q +E I + L  +L    + G P    +    +  +L A Q  +  TS W   +L +   
Sbjct: 279 QSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKT 338

Query: 304 AIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLVHED 363
             +    E   V GE               L+   +LD  ++ETLRLR  P ++ ++   
Sbjct: 339 LQKKCYLEQKTVCGE------NLPPLTYDQLKDLNLLDRCIKETLRLR--PPIMIMMRMA 390

Query: 364 YTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFFKTG 423
            T +  +G  Y    G  + + P ++  +  D   E   F  DR+L  N +       +G
Sbjct: 391 RTPQTVAG--YTIPPGHQVCVSPTVNQRL-KDSWVERLDFNPDRYLQDNPA-------SG 440

Query: 424 KKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVD 467
           +K  +  +P+G+G   C G  FA  ++K     M+  ++ +L+D
Sbjct: 441 EKFAY--VPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLID 482


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 69/215 (32%), Positives = 93/215 (43%), Gaps = 27/215 (12%)

Query: 282 ASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLD 341
           A    T  T  +ALL LLKHPE    V+EE  +V+G  R    Q          H P  D
Sbjct: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQD-------RSHMPYTD 349

Query: 342 SVVEETLR-LRAAPTLL-RLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPE 399
           +VV E  R +   PT L   V  D   +      YL   G  + L    SV  D    P 
Sbjct: 350 AVVHEVQRYIDLLPTSLPHAVTCDIKFR-----NYLIPKGTTI-LISLTSVLHDNKEFPN 403

Query: 400 PTVFKYDRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVT 459
           P +F    FL+  G+     FK  K    Y MP+ +G  IC G   A  E+ LF+  ++ 
Sbjct: 404 PEMFDPHHFLDEGGN-----FKKSK----YFMPFSAGKRICVGEALAGMELFLFLTSILQ 454

Query: 460 HFDLE-LVDPDTPLPHVDPQRWGFGTMQPSHDVRF 493
           +F+L+ LVDP        P   GF ++ P + + F
Sbjct: 455 NFNLKSLVDPKN--LDTTPVVNGFASVPPFYQLCF 487


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 68/222 (30%), Positives = 97/222 (43%), Gaps = 35/222 (15%)

Query: 279 MLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTP 338
           +L A    T  T  +ALL LLKHPE    V+EE  +V+G  R    Q          H P
Sbjct: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRG-------HMP 346

Query: 339 VLDSVVEETLR-LRAAPTLL-RLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDI 396
             D+VV E  R +   PT L   V  D   +      YL   G  + L    SV  D   
Sbjct: 347 YTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR-----NYLIPKGTTI-LTSLTSVLHDNKE 400

Query: 397 HPEPTVFKYDRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILL 456
            P P +F    FL+  G+ K           +Y MP+ +G  IC G   A  E+ LF+  
Sbjct: 401 FPNPEMFDPRHFLDEGGNFKKS---------NYFMPFSAGKRICVGEGLARMELFLFLTF 451

Query: 457 MVTHFDLE-LVDP----DTPLPHVDPQRWGFGTMQPSHDVRF 493
           ++ +F+L+ L+DP     TP+ +      GF ++ P + + F
Sbjct: 452 ILQNFNLKSLIDPKDLDTTPVVN------GFASVPPFYQLCF 487


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 63/215 (29%), Positives = 92/215 (42%), Gaps = 27/215 (12%)

Query: 282 ASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLD 341
           A    T  T  + LL LLKHPE    V+EE   V+G  R    Q  +       H P  D
Sbjct: 297 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRS-------HMPYTD 349

Query: 342 SVVEETLRLR-AAPT-LLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPE 399
           +VV E  R     PT +   V  D   +      YL   G  +       +H D +  P 
Sbjct: 350 AVVHEIQRYSDLVPTGVPHAVTTDTKFR-----NYLIPKGTTIMALLTSVLHDDKEF-PN 403

Query: 400 PTVFKYDRFLNPNGS-RKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMV 458
           P +F    FL+ NG+ +K D+F          MP+ +G  IC G   A  E+ LF+  ++
Sbjct: 404 PNIFDPGHFLDKNGNFKKSDYF----------MPFSAGKRICAGEGLARMELFLFLTTIL 453

Query: 459 THFDLELVDPDTPLPHVDPQRWGFGTMQPSHDVRF 493
            +F+L+ VD D    +      G  ++ PS+ + F
Sbjct: 454 QNFNLKSVD-DLKNLNTTAVTKGIVSLPPSYQICF 487


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 53/187 (28%), Positives = 85/187 (45%), Gaps = 22/187 (11%)

Query: 279 MLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTP 338
           ML A    T  T  W +  L +HPE  + V  E  + LGE  + T          +   P
Sbjct: 177 MLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAAD-------VPKVP 229

Query: 339 VLDSVVEETLRL-RAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIH 397
           ++ ++++ETLRL    P   R+  ED  +       YL   G  LAL  Y + + D +  
Sbjct: 230 LVRALLKETLRLFPVLPGNGRVTQEDLVIG-----GYLIPKGTQLALCHYATSYQDENF- 283

Query: 398 PEPTVFKYDRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLM 457
           P    F+ +R+L      +VD F +        +P+G GV  C GR  A  E+ L ++ +
Sbjct: 284 PRAKEFRPERWLRKGDLDRVDNFGS--------IPFGHGVRSCIGRRIAELEIHLVVIQL 335

Query: 458 VTHFDLE 464
           + HF+++
Sbjct: 336 LQHFEIK 342


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 120/529 (22%), Positives = 203/529 (38%), Gaps = 96/529 (18%)

Query: 12  LVVIAGYLCLPGMLRQRRPWEP---PLDKGTVPWLGHAMAF-RKNMFEFLKRMRTKHGDV 67
           L ++ G L L   L QR P      P     +P LG+ +   R+ + +   R R K+GDV
Sbjct: 9   LALLTGLLLL---LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDV 65

Query: 68  FTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLV---LKVFGYRSVQGDHEMI- 123
           FTV LG +    +    +    L D       G+    +V    + +G     G+   + 
Sbjct: 66  FTVHLGPRPVVMLCGVEAIREALVDKAEAFS-GRGKIAMVDPFFRGYGVIFANGNRWKVL 124

Query: 124 --HSASTKHLRGDGLKDLNETMLDSLSFV---MLTSKGWSLDASCWHEDSLFRFCYYILF 178
              S +T    G G + + E + +    +   +  SKG  +D +   +         I+F
Sbjct: 125 RRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVF 184

Query: 179 TAGYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHK 238
                  F Y   ++Q+ L+   LF  ++ F L+   F             G+L  LF  
Sbjct: 185 G----KRFHY---QDQEFLKMLNLF--YQTFSLISSVF-------------GQLFELFSG 222

Query: 239 MLSV---SHSQ---EKEGISNWLGNMLQFLREQGVPSAMQDKFNFMML------------ 280
            L     +H Q     + I+ ++G+ ++  RE   PSA +D  +  +L            
Sbjct: 223 FLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSE 282

Query: 281 --------------WASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQS 326
                         +A    T  T  +  L +LK+P     V  E  QV+G  R      
Sbjct: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP---- 338

Query: 327 FAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFP 386
              +L      P  ++V+ E  R      LL +       + +S + Y+      + L  
Sbjct: 339 ---ELHDRAKMPYTEAVIYEIQRF---SDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL 392

Query: 387 YLSVHMDPDIHPEPTVFKYDRFLNPNGS-RKVDFFKTGKKIHHYTMPWGSGVSICPGRFF 445
             ++H DP    +P  F  D FL+ NG+ +K + F          +P+  G  IC G   
Sbjct: 393 STALH-DPHYFEKPDAFNPDHFLDANGALKKTEAF----------IPFSLGKRICLGEGI 441

Query: 446 ALSEVKLFILLMVTHFDLELVDPDTPLP-HVDPQRWGFGTMQPSHDVRF 493
           A +E+ LF   ++ +F   +  P  P    + PQ  G G + P++ +RF
Sbjct: 442 ARAELFLFFTTILQNF--SMASPVAPEDIDLTPQECGVGKIPPTYQIRF 488


>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
           precursor [Homo sapiens]
          Length = 531

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 55/194 (28%), Positives = 89/194 (45%), Gaps = 22/194 (11%)

Query: 279 MLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTP 338
           +L A    T  T  WAL +L K PE   A+ EE   V+   ++   + FA       H P
Sbjct: 332 LLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFA-------HMP 384

Query: 339 VLDSVVEETLRL-RAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIH 397
           +L +V++ETLRL    PT  R++ ++  +       +LF          Y+ V  DP   
Sbjct: 385 LLKAVLKETLRLYPVVPTNSRIIEKEIEV-----DGFLFPKNTQFVFCHYV-VSRDPTAF 438

Query: 398 PEPTVFKYDRFLNPNGSRKVDFFKTGKKIHHY-TMPWGSGVSICPGRFFALSEVKLFILL 456
            EP  F+  R+L  +         T +  H + ++P+G GV  C GR  A  E++L +  
Sbjct: 439 SEPESFQPHRWLRNSQP------ATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLAR 492

Query: 457 MVTHFDLELVDPDT 470
           ++  + + L  P+T
Sbjct: 493 LIQKYKVVLA-PET 505


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 71/258 (27%), Positives = 106/258 (41%), Gaps = 48/258 (18%)

Query: 258 MLQFLREQGVPSAMQDKFNFMM-----LWASQGNTGPTSFWALLYLLKHPEAIRAVREEA 312
           +L+  +E+  P       N +M     L+A       T  + LL L+K+P   + VREE 
Sbjct: 273 LLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREEL 332

Query: 313 TQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRA------APTLLRLVH-EDYT 365
            + LG  +       A  LG     P  D+V+ E  RL A        TL+R      YT
Sbjct: 333 NRELGAGQ-------APSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYT 385

Query: 366 LKMSSGQEYLFRHGDILALFPYL-SVHMDPDIHPEPTVFKYDRFLNPNGS-RKVDFFKTG 423
           L   +             +FP L S+  DP+I   P  F  DRFL+ +G  RK       
Sbjct: 386 LPQGT------------EVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRK------- 426

Query: 424 KKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRWGFG 483
              H   +P+  G  +C G   A +E+ LF   ++  F LE   P   L  + P   G  
Sbjct: 427 ---HEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTL-SLKPTVSGLF 482

Query: 484 TMQPSHDVRFRYRLHPTE 501
            + P+    F+ ++ PT+
Sbjct: 483 NIPPA----FQLQVRPTD 496


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 112/505 (22%), Positives = 203/505 (40%), Gaps = 67/505 (13%)

Query: 8   LGALLVVIAGYLC-----LPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRMRT 62
           L ALL++   YL       PG    +     PL  G++P+L        N F+  K    
Sbjct: 4   LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPL-VGSLPFLPRHGHMHNNFFKLQK---- 58

Query: 63  KHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYR------SV 116
           K+G +++V++G +    V        +L   ++  DF    +   L +          + 
Sbjct: 59  KYGPIYSVRMGTKTTVIVGHHQLAKEVL--IKKGKDFSGRPQMATLDIASNNRKGIAFAD 116

Query: 117 QGDHEMIH---SASTKHLRGDGLKDLNETMLDSLSFV---MLTSKGWSLDASCWHEDSLF 170
            G H  +H   + +T  L  DG + L + +   +S +   + T  G S+D S     ++ 
Sbjct: 117 SGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVT 176

Query: 171 RFCYYILFTAGYLSLFGYTKDKEQDLLQA-GELFMEFRKFDLLFPRFVYSLLWPREWLE- 228
                I F   Y +      D E +++Q   E  ++    D L     +  ++P + LE 
Sbjct: 177 NVISLICFNTSYKN-----GDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEK 231

Query: 229 ----VGRLQRLFHKML-SVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMM---- 279
               V     L +K+L +       + I+N L  ++Q        +A  D+ + ++    
Sbjct: 232 LKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNH 291

Query: 280 --------LWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKL 331
                     A    T     W L +LL +P+  + + EE  Q +G +R  T       +
Sbjct: 292 ILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPT-------I 344

Query: 332 GALQHTPVLDSVVEETLRLRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVH 391
                  +L++ + E LRLR  P    L+     +  S G E+    G  + +  +   H
Sbjct: 345 SDRNRLLLLEATIREVLRLR--PVAPMLIPHKANVDSSIG-EFAVDKGTEVIINLWALHH 401

Query: 392 MDPDIHPEPTVFKYDRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVK 451
            + + H +P  F  +RFLNP G++ +        + +  +P+G+G   C G   A  E+ 
Sbjct: 402 NEKEWH-QPDQFMPERFLNPAGTQLIS-----PSVSY--LPFGAGPRSCIGEILARQELF 453

Query: 452 LFILLMVTHFDLELVDPDTPLPHVD 476
           L +  ++  FDLE+ D D  LP ++
Sbjct: 454 LIMAWLLQRFDLEVPD-DGQLPSLE 477


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 64/219 (29%), Positives = 93/219 (42%), Gaps = 29/219 (13%)

Query: 279 MLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTP 338
           M  A    T  T  + LL LLK+PE    V+EE   V+G  R    Q          H P
Sbjct: 235 MFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQD-------RSHMP 287

Query: 339 VLDSVVEETLR-LRAAPT-LLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDI 396
             D+VV E  R +   PT L   V  D   K      YL   G  +       +H D + 
Sbjct: 288 YTDAVVHEIQRYIDLLPTNLPHAVTCDVKFK-----NYLIPKGTTIITSLTSVLHNDKEF 342

Query: 397 HPEPTVFKYDRFLNPNGS-RKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFIL 455
            P P +F    FL+ +G+ +K D+F          MP+ +G  +C G   A  E+ LF+ 
Sbjct: 343 -PNPEMFDPGHFLDKSGNFKKSDYF----------MPFSAGKRMCMGEGLARMELFLFLT 391

Query: 456 LMVTHFDLE-LVDPDTPLPHVDPQRWGFGTMQPSHDVRF 493
            ++ +F+L+  VDP      + P    FG + P + + F
Sbjct: 392 TILQNFNLKSQVDPKD--IDITPIANAFGRVPPLYQLCF 428


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 64/219 (29%), Positives = 93/219 (42%), Gaps = 29/219 (13%)

Query: 279 MLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTP 338
           M  A    T  T  + LL LLK+PE    V+EE   V+G  R    Q          H P
Sbjct: 294 MFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQD-------RSHMP 346

Query: 339 VLDSVVEETLR-LRAAPT-LLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDI 396
             D+VV E  R +   PT L   V  D   K      YL   G  +       +H D + 
Sbjct: 347 YTDAVVHEIQRYIDLLPTNLPHAVTCDVKFK-----NYLIPKGTTIITSLTSVLHNDKEF 401

Query: 397 HPEPTVFKYDRFLNPNGS-RKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFIL 455
            P P +F    FL+ +G+ +K D+F          MP+ +G  +C G   A  E+ LF+ 
Sbjct: 402 -PNPEMFDPGHFLDKSGNFKKSDYF----------MPFSAGKRMCMGEGLARMELFLFLT 450

Query: 456 LMVTHFDLE-LVDPDTPLPHVDPQRWGFGTMQPSHDVRF 493
            ++ +F+L+  VDP      + P    FG + P + + F
Sbjct: 451 TILQNFNLKSQVDPKD--IDITPIANAFGRVPPLYQLCF 487


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 48/189 (25%), Positives = 84/189 (44%), Gaps = 29/189 (15%)

Query: 293 WALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRA 352
           W L +L KHPE     R+E  ++L +     ++    +   L   P L   ++E+LRL  
Sbjct: 339 WVLYHLAKHPEYQEQCRQEVQELLKD-----REPIEIEWDDLAQLPFLTMCIKESLRLHP 393

Query: 353 -APTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNP 411
             P + R   +D+ L        +   G I+ L   + +H +P + P+P V+   RF   
Sbjct: 394 PVPVISRCCTQDFVLPDGR----VIPKG-IVCLINIIGIHYNPTVWPDPEVYDPFRFDQE 448

Query: 412 NGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTP 471
           N   +              +P+ +G   C G+ FA++E+K+ + L + HF +        
Sbjct: 449 NIKERSPLA---------FIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI-------- 491

Query: 472 LP-HVDPQR 479
           LP H +P+R
Sbjct: 492 LPTHTEPRR 500


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 48/189 (25%), Positives = 84/189 (44%), Gaps = 29/189 (15%)

Query: 293 WALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRA 352
           W L +L KHPE     R+E  ++L +     ++    +   L   P L   ++E+LRL  
Sbjct: 339 WVLYHLAKHPEYQEQCRQEVQELLKD-----REPIEIEWDDLAQLPFLTMCIKESLRLHP 393

Query: 353 -APTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNP 411
             P + R   +D+ L        +   G I+ L   + +H +P + P+P V+   RF   
Sbjct: 394 PVPVISRCCTQDFVLPDGR----VIPKG-IVCLINIIGIHYNPTVWPDPEVYDPFRFDQE 448

Query: 412 NGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTP 471
           N   +              +P+ +G   C G+ FA++E+K+ + L + HF +        
Sbjct: 449 NIKERSPLA---------FIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI-------- 491

Query: 472 LP-HVDPQR 479
           LP H +P+R
Sbjct: 492 LPTHTEPRR 500


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 53/188 (28%), Positives = 86/188 (45%), Gaps = 27/188 (14%)

Query: 293 WALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRA 352
           W L  L +HPE     R+E  ++L +     +     +   L   P L   V+E+LRL  
Sbjct: 339 WVLYNLARHPEYQERCRQEVQELLKD-----RDPKEIEWDDLAQLPFLTMCVKESLRLHP 393

Query: 353 -APTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNP 411
            AP + R   +D  L        +   G I  L   + VH +P + P+P V+   RF +P
Sbjct: 394 PAPFISRCCTQDIVLPDGR----VIPKG-ITCLIDIIGVHHNPTVWPDPEVYDPFRF-DP 447

Query: 412 NGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTP 471
             S+       G+    + +P+ +G   C G+ FA++E+K+ + LM+ HF      PD  
Sbjct: 448 ENSK-------GRSPLAF-IPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFL---PD-- 494

Query: 472 LPHVDPQR 479
             H +P+R
Sbjct: 495 --HTEPRR 500


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 51/192 (26%), Positives = 82/192 (42%), Gaps = 25/192 (13%)

Query: 287 TGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEE 346
           T  T  WA+++LL HPE  + ++EE    LG     ++  +  +       P+L++ + E
Sbjct: 267 TANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR----ARLPLLNATIAE 322

Query: 347 TLRLRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYL-SVHMDPDIHPEPTVFKY 405
            LRLR     L L H   T + SS   Y    G +  + P L   H+D  +   P  F  
Sbjct: 323 VLRLRPV-VPLALPHR--TTRPSSISGYDIPEGTV--IIPNLQGAHLDETVWERPHEFWP 377

Query: 406 DRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLEL 465
           DRFL P  + +              + +G G  +C G    L+ ++LF++L        L
Sbjct: 378 DRFLEPGKNSR-------------ALAFGCGARVCLGE--PLARLELFVVLTRLLQAFTL 422

Query: 466 VDPDTPLPHVDP 477
           +     LP + P
Sbjct: 423 LPSGDALPSLQP 434


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 51/192 (26%), Positives = 82/192 (42%), Gaps = 25/192 (13%)

Query: 287 TGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEE 346
           T  T  WA+++LL HPE  + ++EE    LG     ++  +  +       P+L++ + E
Sbjct: 297 TANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDR----ARLPLLNATIAE 352

Query: 347 TLRLRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYL-SVHMDPDIHPEPTVFKY 405
            LRLR     L L H   T + SS   Y    G +  + P L   H+D  +   P  F  
Sbjct: 353 VLRLRPV-VPLALPHR--TTRPSSISGYDIPEGTV--IIPNLQGAHLDETVWERPHEFWP 407

Query: 406 DRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLEL 465
           DRFL P  + +              + +G G  +C G    L+ ++LF++L        L
Sbjct: 408 DRFLEPGKNSR-------------ALAFGCGARVCLGE--PLARLELFVVLTRLLQAFTL 452

Query: 466 VDPDTPLPHVDP 477
           +     LP + P
Sbjct: 453 LPSGDALPSLQP 464


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 52/188 (27%), Positives = 81/188 (43%), Gaps = 24/188 (12%)

Query: 279 MLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTP 338
           +L A       T  WAL  L +HPE   A+  E T     A L    S       L   P
Sbjct: 314 LLLAGVDTVSNTLSWALYELSRHPEVQTALHSEIT-----AALSPGSSAYPSATVLSQLP 368

Query: 339 VLDSVVEETLRLR-AAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIH 397
           +L +VV+E LRL    P   R+  +D  +      +Y+     ++ L  Y +   DP   
Sbjct: 369 LLKAVVKEVLRLYPVVPGNSRVPDKDIHVG-----DYIIPKNTLVTLCHY-ATSRDPAQF 422

Query: 398 PEPTVFKYDRFLNPNGSRKVDFFKTGKKIHHY-TMPWGSGVSICPGRFFALSEVKLFILL 456
           PEP  F+  R+L             G   H + ++P+G G   C GR  A  E+++ +  
Sbjct: 423 PEPNSFRPARWLGE-----------GPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQ 471

Query: 457 MVTHFDLE 464
           ++THF+++
Sbjct: 472 ILTHFEVQ 479


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 50/175 (28%), Positives = 77/175 (44%), Gaps = 26/175 (14%)

Query: 293 WALLYLLKHPEAIRAVREEATQVLGEA-RLETKQSFAFKLGALQHTPVLDSVVEETLRL- 350
           W+L  L  +PE  + V  E   V G++ R  T +        L+    L+ V++ETLRL 
Sbjct: 340 WSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVED-------LKKLRYLECVIKETLRLF 392

Query: 351 RAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLN 410
            + P   R V ED  +       Y    G    + PY ++H DP   P P  F+ +RF  
Sbjct: 393 PSVPLFARSVSEDCEVA-----GYRVLKGTEAVIIPY-ALHRDPRYFPNPEEFQPERFFP 446

Query: 411 PNGSRKVDFFKTGKKIHHYT-MPWGSGVSICPGRFFALSEVKLFILLMVTHFDLE 464
            N   +          H Y  +P+ +G   C G+ FA+ E K  +  ++ HF +E
Sbjct: 447 ENAQGR----------HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIE 491


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 115/521 (22%), Positives = 209/521 (40%), Gaps = 58/521 (11%)

Query: 1   MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFR-KNMFEFLKR 59
           M+  G +L ALLV +   + +    +++   + P     +P++G+ +    + M+  L +
Sbjct: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 60  MRTKHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDF-GQYAK-KLVLKVFGYRSVQ 117
           +  ++G VFT+ LG +    +    +    L D   +    G+ A    V K +G     
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN 120

Query: 118 GDH-EMIHSASTKHLR--GDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCY 174
           G+  + +   S   LR  G G + + E + +   F++   +G    A+      L R   
Sbjct: 121 GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTG-GANIDPTFFLSRTVS 179

Query: 175 YILFTAGYLSLFGYTKDKE-QDLLQ------------AGELFMEFRKFDLLFPRFVYSLL 221
            ++ +  +   F Y KDKE   LL+             G+L+  F       P       
Sbjct: 180 NVISSIVFGDRFDY-KDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF 238

Query: 222 WPREWLEVGRLQRLFHKMLSVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMM-- 279
              + LE    +++ H   ++  +  ++ I ++L  M +   E+  P+      N +M  
Sbjct: 239 QLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQE---EEKNPNTEFYLKNLVMTT 295

Query: 280 --LWASQGNTGPTSF-WALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQH 336
             L+     T  T+  +  L L+KHPE    V EE  +V+G+ R    +  A        
Sbjct: 296 LNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRA-------K 348

Query: 337 TPVLDSVVEETLRLR--AAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYL-SVHMD 393
            P +++V+ E  R       +L R V +D     +  +++    G    ++P L SV  D
Sbjct: 349 MPYMEAVIHEIQRFGDVIPMSLARRVKKD-----TKFRDFFLPKG--TEVYPMLGSVLRD 401

Query: 394 PDIHPEPTVFKYDRFLNPNGS-RKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKL 452
           P     P  F    FLN  G  +K D F          +P+  G   C G   A  E+ L
Sbjct: 402 PSFFSNPQDFNPQHFLNEKGQFKKSDAF----------VPFSIGKRNCFGEGLARMELFL 451

Query: 453 FILLMVTHFDLELVDPDTPLPHVDPQRWGFGTMQPSHDVRF 493
           F   ++ +F L+       +  V P+  GF T+  ++ + F
Sbjct: 452 FFTTVMQNFRLKSSQSPKDI-DVSPKHVGFATIPRNYTMSF 491


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 50/188 (26%), Positives = 82/188 (43%), Gaps = 27/188 (14%)

Query: 293 WALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLR- 351
           W L +L KHPE     R+E  ++     L+ ++    +   L H P L   ++E+LRL  
Sbjct: 339 WVLYHLAKHPEYQERCRQEVQEL-----LKDREPKEIEWDDLAHLPFLTMCMKESLRLHP 393

Query: 352 AAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNP 411
             P + R V +D  L        +   G I+ L      H +P + P+P V+   RF   
Sbjct: 394 PVPVISRHVTQDIVLP----DGRVIPKG-IICLISVFGTHHNPAVWPDPEVYDPFRFDPE 448

Query: 412 NGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTP 471
           N   +              +P+ +G   C G+ FA++E+K+ + L +  F    V PD  
Sbjct: 449 NIKERSPL---------AFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF---RVLPD-- 494

Query: 472 LPHVDPQR 479
             H +P+R
Sbjct: 495 --HTEPRR 500


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 79/307 (25%), Positives = 128/307 (41%), Gaps = 47/307 (15%)

Query: 205 EFRKFDLLFPRFVYSLLWPR-----EWLEVGRLQRLFHKMLSVS-HSQEKEGISNWLGNM 258
           +F KF  L P F+  +L+P      E L V    +     LS S +  +K  +++   + 
Sbjct: 209 KFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHR 268

Query: 259 LQFL---------REQGVPSAMQD----KFNFMMLWASQGNTGPTSFWALLYLLKHPEAI 305
           L FL         +E     A+ D      + + ++A    T     + L  L  HP+  
Sbjct: 269 LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQ 328

Query: 306 RAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLVHEDYT 365
           + +++E   VL      T         A+     LD VV ETLRL   P  +RL   + T
Sbjct: 329 QKLQKEIDAVLPNKAPPTYD-------AVVQMEYLDMVVNETLRL--FPVAIRL---ERT 376

Query: 366 LKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFFKTGKK 425
            K       +F     + + P  ++H DP    EP  F+ +RF     S+K D       
Sbjct: 377 CKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-----SKKKDSIDP--- 428

Query: 426 IHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLP-HVDPQRWGFGT 484
            + YT P+G+G   C G  FAL  +KL ++ ++ +F  +    +T +P  +D Q    G 
Sbjct: 429 -YIYT-PFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPC-KETQIPLKLDTQ----GL 481

Query: 485 MQPSHDV 491
           +QP   +
Sbjct: 482 LQPEKPI 488


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 49/189 (25%), Positives = 81/189 (42%), Gaps = 21/189 (11%)

Query: 276 NFMMLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQ 335
           + ++++A+   T  T  + +  L  HP+  + ++EE   VL      T         AL 
Sbjct: 299 SIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYD-------ALV 351

Query: 336 HTPVLDSVVEETLRLRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPD 395
               LD VV ETLRL   P + R+       K       +F    +  + P  ++H DP 
Sbjct: 352 QMEYLDMVVNETLRL--FPVVSRVTR---VCKKDIEINGVFIPKGLAVMVPIYALHHDPK 406

Query: 396 IHPEPTVFKYDRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFIL 455
              EP  F  +RF   N        K    ++ Y +P+G+G   C G  FAL+ +KL ++
Sbjct: 407 YWTEPEKFCPERFSKKN--------KDSIDLYRY-IPFGAGPRNCIGMRFALTNIKLAVI 457

Query: 456 LMVTHFDLE 464
             + +F  +
Sbjct: 458 RALQNFSFK 466


>gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide 1
           isoform 1 [Homo sapiens]
          Length = 497

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 99/459 (21%), Positives = 177/459 (38%), Gaps = 57/459 (12%)

Query: 34  PLDKGTV--PWLGHAMAFRKNMFEFLKRMRTKHGDVFTVQLGGQYFTFVMDPLSFGSILK 91
           PL  GT+  P+ G  +       +FL+  R K+G ++   L G+    VM          
Sbjct: 43  PLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGA-------- 94

Query: 92  DTQRKLDFGQYAKKLVLKVFGYRSVQGDHEM--IHSASTKHLRGDGLKDLNETMLDSLSF 149
           D  R++  G++    V      R++ G   +  +H +S K  +   ++  +   L+    
Sbjct: 95  DNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVP 154

Query: 150 VMLTSKGWSLDA--SCWHEDSL---------FRFCYYILFTAGYLSLFGYTKDKEQDLLQ 198
           V+    G SL+   SC     L         FR    IL   G         D EQ L++
Sbjct: 155 VITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILL--GCEPQLAGDGDSEQQLVE 212

Query: 199 AGELFMEFRKFDLLFPRFV-----YSLLWPREWLEVGRLQRLFHKMLSVSHSQEKEGISN 253
           A   F E  +     P  V     Y  +  R  +     Q +  K+  +  S+  +G  +
Sbjct: 213 A---FEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKD 269

Query: 254 WLGNMLQFLREQGVPSAMQ--DKFNFMMLWASQGNTGPTSFWALLYLLKHPEAIRAVREE 311
            L  +++   E+G    MQ   + +  +L+     T   +   + YL  +P  ++ VREE
Sbjct: 270 ALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREE 329

Query: 312 ATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRA-APTLLRLVHEDYTLKMSS 370
                     ++ Q     +  L+    +  V++ETLRL    P   R+  + + L    
Sbjct: 330 LKSK--GLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELN--- 384

Query: 371 GQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFL--NPNGSRKVDFFKTGKKIHH 428
              Y    G  + ++     H   +I      F  DRF+  +P  + +  F         
Sbjct: 385 --GYQIPKGWNV-IYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSF--------- 432

Query: 429 YTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVD 467
             +P+G G+  C G+ FA   +K+F + +  H D +L++
Sbjct: 433 --IPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLN 469


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 47/189 (24%), Positives = 77/189 (40%), Gaps = 21/189 (11%)

Query: 276 NFMMLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQ 335
           + + ++A    T     + +  L  HP+  + ++EE   VL      T  +       + 
Sbjct: 299 SIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT-------VL 351

Query: 336 HTPVLDSVVEETLRLRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPD 395
               LD VV ETLRL   P  +RL   +   K       +F    ++ + P  ++H DP 
Sbjct: 352 QMEYLDMVVNETLRL--FPIAMRL---ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPK 406

Query: 396 IHPEPTVFKYDRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFIL 455
              EP  F  +RF   N      +  T         P+GSG   C G  FAL  +KL ++
Sbjct: 407 YWTEPEKFLPERFSKKNKDNIDPYIYT---------PFGSGPRNCIGMRFALMNMKLALI 457

Query: 456 LMVTHFDLE 464
            ++ +F  +
Sbjct: 458 RVLQNFSFK 466


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.141    0.448 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,561,640
Number of Sequences: 37866
Number of extensions: 877208
Number of successful extensions: 2464
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 2331
Number of HSP's gapped (non-prelim): 89
length of query: 501
length of database: 18,247,518
effective HSP length: 106
effective length of query: 395
effective length of database: 14,233,722
effective search space: 5622320190
effective search space used: 5622320190
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.