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Search of human proteins with 166064027
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
sapiens]
(592 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo sapi... 1197 0.0
gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo sapi... 922 0.0
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens] 401 e-112
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens] 312 6e-85
gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens] 303 2e-82
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 259 6e-69
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 259 6e-69
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 199 6e-51
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 198 1e-50
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 196 4e-50
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 190 3e-48
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 188 1e-47
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 186 4e-47
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 186 4e-47
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 184 2e-46
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 183 4e-46
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 182 6e-46
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 182 6e-46
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 182 8e-46
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 177 3e-44
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 176 4e-44
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 176 4e-44
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 176 4e-44
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 174 2e-43
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 174 2e-43
gi|27477122 intestinal cell kinase [Homo sapiens] 174 2e-43
gi|7662388 intestinal cell kinase [Homo sapiens] 174 2e-43
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 171 1e-42
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens] 171 1e-42
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 171 2e-42
>gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
sapiens]
Length = 592
Score = 1197 bits (3098), Expect = 0.0
Identities = 592/592 (100%), Positives = 592/592 (100%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
Query: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN
Sbjct: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
Query: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK
Sbjct: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
Query: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP
Sbjct: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
Query: 241 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK 300
QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK
Sbjct: 241 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK 300
Query: 301 AKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRV 360
AKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRV
Sbjct: 301 AKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRV 360
Query: 361 IKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKE 420
IKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKE
Sbjct: 361 IKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKE 420
Query: 421 NPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQE 480
NPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQE
Sbjct: 421 NPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQE 480
Query: 481 DPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGME 540
DPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGME
Sbjct: 481 DPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGME 540
Query: 541 VKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW 592
VKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW
Sbjct: 541 VKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW 592
>gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo
sapiens]
Length = 455
Score = 922 bits (2382), Expect = 0.0
Identities = 455/455 (100%), Positives = 455/455 (100%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
Query: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN
Sbjct: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
Query: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK
Sbjct: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
Query: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP
Sbjct: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
Query: 241 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK 300
QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK
Sbjct: 241 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK 300
Query: 301 AKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRV 360
AKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRV
Sbjct: 301 AKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRV 360
Query: 361 IKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKE 420
IKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKE
Sbjct: 361 IKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKE 420
Query: 421 NPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVR 455
NPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVR
Sbjct: 421 NPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVR 455
>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
Length = 493
Score = 401 bits (1031), Expect = e-112
Identities = 215/480 (44%), Positives = 305/480 (63%), Gaps = 27/480 (5%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQS-VNKIAMREIKFLKQFHH 59
ME YE LG VGEGSYG VMKC++K+TG+IVAIK F E + V KIAMREIK LKQ H
Sbjct: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
ENLVNL+EV ++KK+ +LVFEF+DHT+LD+L+ + +GL+ + ++KYLFQI+ I + HS+
Sbjct: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
Query: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYG 179
NIIHRDIKPENILVSQSG+ KLCDFGFARTLAAPG++YTDYVATRWYRAPEL++ D YG
Sbjct: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
Query: 180 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 239
K VD+WA+GC++ EM G P P SD+D L+ I++ +GNL P Q +F+K+P+FAGV L
Sbjct: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
Query: 240 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPEL 299
P+++ + ++YPKL+ ++ D+ CL IDP R ++LLHH++F DGF E+F EL
Sbjct: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL 300
Query: 300 KAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVR 359
+ K+ ++A+ SL K K +++ E KD+ TL+ + PK +
Sbjct: 301 QLKVQKDARNVSLSK-KSQNRKKEKEKDDSLVEERKTLVVQ-------DTNADPKIKDYK 352
Query: 360 VIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPST---NCN 416
+ K+KG + D + +K + H N I PST +C+
Sbjct: 353 LFKIKGSKIDGEKAEKGNRASNASCLHDSRTSH--------------NKIVPSTSLKDCS 398
Query: 417 GLKENPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPN 476
+ + SV +PP+ N + +A +++S + ++ + +T SI V PN
Sbjct: 399 NVSVDHTRNPSVAIPPLT-HNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPN 457
>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
Length = 358
Score = 312 bits (799), Expect = 6e-85
Identities = 147/299 (49%), Positives = 202/299 (67%), Gaps = 1/299 (0%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSV-NKIAMREIKFLKQFHH 59
ME YE +GK+GEGSYG V KC++++TGQIVAIK F E + V KIA+REI+ LKQ H
Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
NLVNL+EVFR+K+++HLVFE+ DHTVL EL Y G+ ++ +Q L+A+++ H +
Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKH 121
Query: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYG 179
N IHRD+KPENIL+++ + KLCDFGFAR L P D YTDYVATRWYR+PEL++ DT YG
Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYG 181
Query: 180 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 239
PVD+WA+GC+ E+ +G P P SD+D L+ I +G+L P Q +FS + F+GV +
Sbjct: 182 PPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKI 241
Query: 240 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPE 298
P + + K+P ++ ++ CL +DP R++ LLHH YF IE E
Sbjct: 242 PDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKE 300
>gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]
Length = 315
Score = 303 bits (777), Expect = 2e-82
Identities = 150/309 (48%), Positives = 211/309 (68%), Gaps = 7/309 (2%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSV-NKIAMREIKFLKQFHH 59
ME YE L K GEGSYG V KC++K +GQ+VA+K F E + V KIA+REI+ LKQ H
Sbjct: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
NLVNLIEVFR+K+K+HLVFE+ DHT+L+EL+ +G+ ++ L+Q L+A+++ H +
Sbjct: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
Query: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYG 179
N IHRDIKPENIL+++ GI K+CDFGFA+ L PGD YTDYVATRWYRAPEL++ DT YG
Sbjct: 121 NCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQYG 179
Query: 180 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 239
VDIWA+GC+ E+ TG P P SD+D L+ I+ +G L P Q+IF + F G+ +
Sbjct: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISI 239
Query: 240 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPEL 299
P+ + + +K+ ++ + + + CL+++P DR++ S LL YF D F E ++
Sbjct: 240 PEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF--DSFQE---AQI 294
Query: 300 KAKLLQEAK 308
K K E +
Sbjct: 295 KRKARNEGR 303
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 259 bits (661), Expect = 6e-69
Identities = 128/332 (38%), Positives = 207/332 (62%), Gaps = 4/332 (1%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE-QSVNKIAMREIKFLKQFHH 59
M +E LG VGEG+YG V+KC+HK T +IVAIK F + E + V + +RE+K L+
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
EN+V L E FR++ K++LVFE+++ +L+ L+ +G+ ++++ Y++Q+++AI + H N
Sbjct: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
Query: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDI-YTDYVATRWYRAPELVLKDTSY 178
+I+HRDIKPEN+L+S + + KLCDFGFAR L+ + YT+YVATRWYR+PEL+L Y
Sbjct: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
Query: 179 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV 238
GK VD+W++GC++ E++ G P P S++D L I +G L +F +P F G+
Sbjct: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
Query: 239 LPQVQHPKNARKKY-PKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMP 297
P V HP++ ++Y LN +L D++ L++DPADR + L+H F +++
Sbjct: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
Query: 298 ELKAKLLQEAKVNSLIKPKESSKENELRKDER 329
+ + ++L ++ K L+ R
Sbjct: 309 RSAKRKPYHVESSTLSNRNQAGKSTALQSHHR 340
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 259 bits (661), Expect = 6e-69
Identities = 128/332 (38%), Positives = 207/332 (62%), Gaps = 4/332 (1%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE-QSVNKIAMREIKFLKQFHH 59
M +E LG VGEG+YG V+KC+HK T +IVAIK F + E + V + +RE+K L+
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
EN+V L E FR++ K++LVFE+++ +L+ L+ +G+ ++++ Y++Q+++AI + H N
Sbjct: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
Query: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDI-YTDYVATRWYRAPELVLKDTSY 178
+I+HRDIKPEN+L+S + + KLCDFGFAR L+ + YT+YVATRWYR+PEL+L Y
Sbjct: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
Query: 179 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV 238
GK VD+W++GC++ E++ G P P S++D L I +G L +F +P F G+
Sbjct: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
Query: 239 LPQVQHPKNARKKY-PKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMP 297
P V HP++ ++Y LN +L D++ L++DPADR + L+H F +++
Sbjct: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
Query: 298 ELKAKLLQEAKVNSLIKPKESSKENELRKDER 329
+ + ++L ++ K L+ R
Sbjct: 309 RSAKRKPYHVESSTLSNRNQAGKSTALQSHHR 340
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 199 bits (506), Expect = 6e-51
Identities = 110/297 (37%), Positives = 165/297 (55%), Gaps = 20/297 (6%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 59
M+M++ + K+GEG+YG V K K++ TGQ+VA+K I + + V A+REI LK+ H
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRL-----RKYLFQILRAID 114
N+V L++V ++K++LVFEF+ +L+ Y L + YLFQ+L+ +
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQ----DLKKYMDSTPGSELPLHLIKSYLFQLLQGVS 116
Query: 115 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLK 174
+ HS+ +IHRD+KP+N+L+++ G KL DFG AR P YT V T WYRAPE++L
Sbjct: 117 FCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLG 176
Query: 175 DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIF 234
Y VDIW++GC+ EM T P S++D L +I +G S ++ P +
Sbjct: 177 SKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDY 236
Query: 235 AGVVLPQVQHPKNARKK----YPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 287
G PK RK P L D++ LQ DP+ RI++ L H YF+
Sbjct: 237 KG------SFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFS 287
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 198 bits (504), Expect = 1e-50
Identities = 113/303 (37%), Positives = 168/303 (55%), Gaps = 33/303 (10%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 59
ME Y + K+GEG+YG V K +HK TGQ+VA+K I E E+ V A+REI LK+ H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHG--LESKRLRKYLFQILRAIDYLH 117
N+V+L +V Q +++L+FEF+ + L G ++S ++ YL+QIL+ I + H
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 118 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTS 177
S ++HRD+KP+N+L+ G KL DFG AR P +YT V T WYR+PE++L
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180
Query: 178 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 237
Y PVDIW++G + E+AT P S++D L +I +G +P+ +
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG--TPNNE------------ 226
Query: 238 VLPQVQHPKNARKKYPKL--------------NGLLADIVHACLQIDPADRISSSDLLHH 283
V P+V+ ++ + +PK NGL D++ L DPA RIS L+H
Sbjct: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGL--DLLSKMLIYDPAKRISGKMALNH 284
Query: 284 EYF 286
YF
Sbjct: 285 PYF 287
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 196 bits (499), Expect = 4e-50
Identities = 112/303 (36%), Positives = 167/303 (55%), Gaps = 33/303 (10%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 59
ME Y + K+GEG+YG V K +HK TGQ+VA+K I E E+ V A+REI LK+ H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHG--LESKRLRKYLFQILRAIDYLH 117
N+V+L +V Q +++L+FEF+ + L G ++S ++ YL+QIL+ I + H
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 118 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTS 177
S ++HRD+KP+N+L+ G KL DFG AR P +YT T WYR+PE++L
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSAR 180
Query: 178 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 237
Y PVDIW++G + E+AT P S++D L +I +G +P+ +
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG--TPNNE------------ 226
Query: 238 VLPQVQHPKNARKKYPKL--------------NGLLADIVHACLQIDPADRISSSDLLHH 283
V P+V+ ++ + +PK NGL D++ L DPA RIS L+H
Sbjct: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGL--DLLSKMLIYDPAKRISGKMALNH 284
Query: 284 EYF 286
YF
Sbjct: 285 PYF 287
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 190 bits (483), Expect = 3e-48
Identities = 105/292 (35%), Positives = 165/292 (56%), Gaps = 10/292 (3%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 59
M+ YE L K+GEG+YGTV K K++ T +IVA+K + + ++ V A+REI LK+ H
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHG-LESKRLRKYLFQILRAIDYLHS 118
+N+V L +V KK+ LVFEF D L + C+G L+ + ++ +LFQ+L+ + + HS
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119
Query: 119 NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSY 178
N++HRD+KP+N+L++++G KL DFG AR P Y+ V T WYR P+++ Y
Sbjct: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179
Query: 179 GKPVDIWALGCMIIEMA-TGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 237
+D+W+ GC+ E+A G P P + D L +I +G + +K P +
Sbjct: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK-- 237
Query: 238 VLPQVQHPKNAR--KKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 287
P +P PKLN D++ L+ +P RIS+ + L H YF+
Sbjct: 238 --PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 188 bits (477), Expect = 1e-47
Identities = 104/305 (34%), Positives = 169/305 (55%), Gaps = 24/305 (7%)
Query: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHHENL 62
YE L K+G+G++G V K +H+ TGQ VA+K + E ++ A+REIK L+ HEN+
Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78
Query: 63 VNLIEVFRQKKK--------IHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAID 114
VNLIE+ R K I+LVF+F +H + L + +++ + +L +
Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138
Query: 115 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLA----APGDIYTDYVATRWYRAPE 170
Y+H N I+HRD+K N+L+++ G+ KL DFG AR + + + YT+ V T WYR PE
Sbjct: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198
Query: 171 LVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHL------ 224
L+L + YG P+D+W GC++ EM T +P + +++ L I G+++P +
Sbjct: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258
Query: 225 QNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHE 284
++ K + G Q + K+ K Y + + D++ L +DPA RI S D L+H+
Sbjct: 259 YELYEKLELVKG----QKRKVKDRLKAYVR-DPYALDLIDKLLVLDPAQRIDSDDALNHD 313
Query: 285 YFTRD 289
+F D
Sbjct: 314 FFWSD 318
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 186 bits (473), Expect = 4e-47
Identities = 105/296 (35%), Positives = 164/296 (55%), Gaps = 20/296 (6%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 59
ME ++ + K+GEG+YG V K ++K TG++VA+K I + + V A+REI LK+ +H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYC-HGLESKRLRKYLFQILRAIDYLHS 118
N+V L++V + K++LVFEF+ + + G+ ++ YLFQ+L+ + + HS
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 119 NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSY 178
+ ++HRD+KP+N+L++ G KL DFG AR P YT V T WYRAPE++L Y
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
Query: 179 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGN----LSPHLQNIFSKSPIF 234
VDIW+LGC+ EM T P S++D L +I +G + P + ++ P F
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
Query: 235 AGVVLPQVQHPKNARKKYPKLNGLLAD----IVHACLQIDPADRISSSDLLHHEYF 286
PK AR+ + K+ L + ++ L DP RIS+ L H +F
Sbjct: 241 ----------PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 186 bits (473), Expect = 4e-47
Identities = 102/289 (35%), Positives = 158/289 (54%), Gaps = 4/289 (1%)
Query: 2 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHEN 61
+ YE L K+GEGSY TV K K K G++VA+K+ + E+ A+RE LK H N
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHAN 174
Query: 62 LVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNI 121
+V L ++ K+ + LVFE++ + + + GL ++ +LFQ+LR + Y+H I
Sbjct: 175 IVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYI 234
Query: 122 IHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKP 181
+HRD+KP+N+L+S +G KL DFG AR + P Y++ V T WYR P+++L T Y
Sbjct: 235 LHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTC 294
Query: 182 VDIWALGCMIIEMATGNPYLPSSSDL-DLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
+D+W +GC+ +EM G P D+ D L +I L +G + P F
Sbjct: 295 LDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERF- 353
Query: 241 QVQHPKNARKKYPKLNGL--LADIVHACLQIDPADRISSSDLLHHEYFT 287
+ KN R+ + KL+ + D+ LQ P +R+S+ L HEYF+
Sbjct: 354 TLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFS 402
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 184 bits (467), Expect = 2e-46
Identities = 100/294 (34%), Positives = 161/294 (54%), Gaps = 19/294 (6%)
Query: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFY----ERPEQSVNKIAMREIKFLKQFHH 59
YE L +GEG + TV K + KNT QIVAIK + +N+ A+REIK L++ H
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
N++ L++ F K I LVF+F++ + ++ L ++ Y+ L+ ++YLH +
Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131
Query: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYG 179
I+HRD+KP N+L+ ++G+ KL DFG A++ +P YT V TRWYRAPEL+ YG
Sbjct: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191
Query: 180 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLS----PHLQNI--FSKSPI 233
VD+WA+GC++ E+ P+LP SDLD L +I +G + P + ++ +
Sbjct: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251
Query: 234 FAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 287
F G+ L + + L D++ +P RI+++ L +YF+
Sbjct: 252 FPGIPLHHI---------FSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 183 bits (464), Expect = 4e-46
Identities = 109/338 (32%), Positives = 174/338 (51%), Gaps = 17/338 (5%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
ME Y L K+GEG+Y TV K + K T +VA+K E+ A+RE+ LK H
Sbjct: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 248
Query: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
N+V L ++ K + LVFE++D + + + + ++ +L+QILR + Y H
Sbjct: 249 NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRK 308
Query: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
++HRD+KP+N+L+++ G KL DFG AR + P Y++ V T WYR P+++L + Y
Sbjct: 309 VLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYST 368
Query: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
+D+W +GC+ EMA+G P P S+ D LH I +G S S + F P
Sbjct: 369 QIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFP 428
Query: 241 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK 300
+ + P+ P+L+ +++ LQ + R+S+ + + H YF G P +
Sbjct: 429 KYK-PQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLG------PRIH 481
Query: 301 AKLLQEAKVNSLIKPKESSKENELRKDE--RKTVYTNT 336
A L + + SL KE +L+KD R + Y T
Sbjct: 482 A-LPESVSIFSL-------KEIQLQKDPGFRNSSYPET 511
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 182 bits (463), Expect = 6e-46
Identities = 97/286 (33%), Positives = 155/286 (54%), Gaps = 1/286 (0%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
+E Y L K+GEG+Y TV K K K T +VA+K E+ A+RE+ LK H
Sbjct: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 227
Query: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
N+V L ++ +K + LVFE++D + L + + ++ +LFQ+LR + Y H
Sbjct: 228 NIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQK 287
Query: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
++HRD+KP+N+L+++ G KL DFG AR + P Y++ V T WYR P+++L T Y
Sbjct: 288 VLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYST 347
Query: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
+D+W +GC+ EMATG P P S+ + LH I +G + + F P
Sbjct: 348 QIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYP 407
Query: 241 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 286
+ + + P+L+ AD++ LQ + +RIS+ D + H +F
Sbjct: 408 KYR-AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 182 bits (463), Expect = 6e-46
Identities = 97/286 (33%), Positives = 155/286 (54%), Gaps = 1/286 (0%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
+E Y L K+GEG+Y TV K K K T +VA+K E+ A+RE+ LK H
Sbjct: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 221
Query: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
N+V L ++ +K + LVFE++D + L + + ++ +LFQ+LR + Y H
Sbjct: 222 NIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQK 281
Query: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
++HRD+KP+N+L+++ G KL DFG AR + P Y++ V T WYR P+++L T Y
Sbjct: 282 VLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYST 341
Query: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
+D+W +GC+ EMATG P P S+ + LH I +G + + F P
Sbjct: 342 QIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYP 401
Query: 241 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 286
+ + + P+L+ AD++ LQ + +RIS+ D + H +F
Sbjct: 402 KYR-AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 446
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 182 bits (462), Expect = 8e-46
Identities = 101/289 (34%), Positives = 165/289 (57%), Gaps = 4/289 (1%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFH- 58
M+ Y LG++GEG++G V K KH TG+IVA+K + R E A+REIK L++
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 59 HENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHS 118
++ +V L VF L FEF+ + + ++H L +++ YL +L+ + + H+
Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120
Query: 119 NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGD-IYTDYVATRWYRAPELVLKDTS 177
NNI+HRD+KP N+L+S SG K+ DFG AR + G +YT VATRWYRAPEL+
Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ 180
Query: 178 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 237
Y + VD+W++GC++ E+ G+P P +D++ L ++ +G +P + ++ P + +
Sbjct: 181 YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 240
Query: 238 VLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 286
+ Q P + P ++ D++ L P RI++S L H+YF
Sbjct: 241 SFKE-QVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 288
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 177 bits (448), Expect = 3e-44
Identities = 100/287 (34%), Positives = 154/287 (53%), Gaps = 4/287 (1%)
Query: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLV 63
Y L K+GEGSY TV K + GQ+VA+K+ E+ V A+RE LK H N+V
Sbjct: 52 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIV 111
Query: 64 NLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIH 123
L ++ K+ + VFE++ + + + GL +R ++FQ+LR + Y+H +++H
Sbjct: 112 LLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLH 171
Query: 124 RDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVD 183
RD+KP+N+L+S G KL DFG AR + P Y+ V T WYR P+ +L T Y +D
Sbjct: 172 RDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELD 231
Query: 184 IWALGCMIIEMATGNPYLPSSSD-LDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQV 242
IW GC+ IEM G P P S+ L+ L KI +G + SK P + P +
Sbjct: 232 IWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFP-L 290
Query: 243 QHPKNARKKYPKLNGL--LADIVHACLQIDPADRISSSDLLHHEYFT 287
P++ + +L + D+ L+ P DR+S+ + L H+YF+
Sbjct: 291 PTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFS 337
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 176 bits (447), Expect = 4e-44
Identities = 105/327 (32%), Positives = 167/327 (51%), Gaps = 15/327 (4%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
+E Y L K+GEG+Y TV K + K T +VA+K E+ A+RE+ LK H
Sbjct: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHA 230
Query: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
N+V L ++ + + LVFE++D + L H + + ++ ++FQ+LR + Y H
Sbjct: 231 NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRK 290
Query: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
I+HRD+KP+N+L+++ G KL DFG AR + P Y++ V T WYR P+++L T Y
Sbjct: 291 ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST 350
Query: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
P+D+W +GC+ EMATG P P S+ + LH I +G + + F P
Sbjct: 351 PIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFP 410
Query: 241 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK 300
P+ P+L+ ++ + L + R+S+ L H YF + + E
Sbjct: 411 -CYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF-------RSLGERV 462
Query: 301 AKLLQEAKVNSLIKPKESSKENELRKD 327
+L A + SL KE +L+KD
Sbjct: 463 HQLEDTASIFSL-------KEIQLQKD 482
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 176 bits (447), Expect = 4e-44
Identities = 105/327 (32%), Positives = 167/327 (51%), Gaps = 15/327 (4%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
+E Y L K+GEG+Y TV K + K T +VA+K E+ A+RE+ LK H
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHA 200
Query: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
N+V L ++ + + LVFE++D + L H + + ++ ++FQ+LR + Y H
Sbjct: 201 NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRK 260
Query: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
I+HRD+KP+N+L+++ G KL DFG AR + P Y++ V T WYR P+++L T Y
Sbjct: 261 ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST 320
Query: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
P+D+W +GC+ EMATG P P S+ + LH I +G + + F P
Sbjct: 321 PIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFP 380
Query: 241 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK 300
P+ P+L+ ++ + L + R+S+ L H YF + + E
Sbjct: 381 -CYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF-------RSLGERV 432
Query: 301 AKLLQEAKVNSLIKPKESSKENELRKD 327
+L A + SL KE +L+KD
Sbjct: 433 HQLEDTASIFSL-------KEIQLQKD 452
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 176 bits (447), Expect = 4e-44
Identities = 105/327 (32%), Positives = 167/327 (51%), Gaps = 15/327 (4%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
+E Y L K+GEG+Y TV K + K T +VA+K E+ A+RE+ LK H
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHA 200
Query: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
N+V L ++ + + LVFE++D + L H + + ++ ++FQ+LR + Y H
Sbjct: 201 NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRK 260
Query: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
I+HRD+KP+N+L+++ G KL DFG AR + P Y++ V T WYR P+++L T Y
Sbjct: 261 ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST 320
Query: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
P+D+W +GC+ EMATG P P S+ + LH I +G + + F P
Sbjct: 321 PIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFP 380
Query: 241 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK 300
P+ P+L+ ++ + L + R+S+ L H YF + + E
Sbjct: 381 -CYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF-------RSLGERV 432
Query: 301 AKLLQEAKVNSLIKPKESSKENELRKD 327
+L A + SL KE +L+KD
Sbjct: 433 HQLEDTASIFSL-------KEIQLQKD 452
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 174 bits (442), Expect = 2e-43
Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 11/293 (3%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 59
+E ++ L ++ EG+YG V + K K T +IVA+K + E+ ++ ++REI + + H
Sbjct: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
Query: 60 ENLVNLIEVF--RQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLH 117
N+V + E+ KI++V +++H + ++ ++ + Q+LR + +LH
Sbjct: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 529
Query: 118 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTS 177
N I+HRD+K N+L+S +GI K+ DFG AR +P YT V T+WYRAPEL+L
Sbjct: 530 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKE 589
Query: 178 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 237
Y VD+W++GC+ E+ T P P +S++D ++K+ ++G S + +S+ P+ +
Sbjct: 590 YSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKM 649
Query: 238 VLPQVQHPKNARKKYPKLNGLLA----DIVHACLQIDPADRISSSDLLHHEYF 286
+HP N +K + LL+ D+++ L P RIS+ D L HEYF
Sbjct: 650 TFS--EHPYNNLRK--RFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 698
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 174 bits (442), Expect = 2e-43
Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 11/293 (3%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 59
+E ++ L ++ EG+YG V + K K T +IVA+K + E+ ++ ++REI + + H
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479
Query: 60 ENLVNLIEVF--RQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLH 117
N+V + E+ KI++V +++H + ++ ++ + Q+LR + +LH
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539
Query: 118 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTS 177
N I+HRD+K N+L+S +GI K+ DFG AR +P YT V T+WYRAPEL+L
Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKE 599
Query: 178 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 237
Y VD+W++GC+ E+ T P P +S++D ++K+ ++G S + +S+ P+ +
Sbjct: 600 YSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKM 659
Query: 238 VLPQVQHPKNARKKYPKLNGLLA----DIVHACLQIDPADRISSSDLLHHEYF 286
+HP N +K + LL+ D+++ L P RIS+ D L HEYF
Sbjct: 660 TFS--EHPYNNLRK--RFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 708
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 174 bits (442), Expect = 2e-43
Identities = 91/293 (31%), Positives = 158/293 (53%), Gaps = 16/293 (5%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
M Y T+ ++G+G+YG+V+ + +G+++AIK + + +RE+K LK+ +H
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA 60
Query: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
N+V L EV R+ ++ +FE++ + ++ +R ++QIL+ + ++H +
Sbjct: 61 NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120
Query: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
HRD+KPEN+L + K+ DFG AR + + YTDYV+TRWYRAPE++L+ T+Y
Sbjct: 121 FFHRDLKPENLLCMGPELVKIADFGLAREIRSKPP-YTDYVSTRWYRAPEVLLRSTNYSS 179
Query: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
P+D+WA+GC++ E+ T P P +S++D + KI +G K+ G L
Sbjct: 180 PIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTP--------KKTDWPEGYQLS 231
Query: 241 QVQH-------PKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 286
+ P N + P + ++ LQ DP R ++S L + YF
Sbjct: 232 SAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF 284
>gi|7662388 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 174 bits (442), Expect = 2e-43
Identities = 91/293 (31%), Positives = 158/293 (53%), Gaps = 16/293 (5%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
M Y T+ ++G+G+YG+V+ + +G+++AIK + + +RE+K LK+ +H
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA 60
Query: 61 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 120
N+V L EV R+ ++ +FE++ + ++ +R ++QIL+ + ++H +
Sbjct: 61 NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120
Query: 121 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK 180
HRD+KPEN+L + K+ DFG AR + + YTDYV+TRWYRAPE++L+ T+Y
Sbjct: 121 FFHRDLKPENLLCMGPELVKIADFGLAREIRSKPP-YTDYVSTRWYRAPEVLLRSTNYSS 179
Query: 181 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 240
P+D+WA+GC++ E+ T P P +S++D + KI +G K+ G L
Sbjct: 180 PIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTP--------KKTDWPEGYQLS 231
Query: 241 QVQH-------PKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 286
+ P N + P + ++ LQ DP R ++S L + YF
Sbjct: 232 SAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF 284
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 171 bits (434), Expect = 1e-42
Identities = 111/302 (36%), Positives = 173/302 (57%), Gaps = 29/302 (9%)
Query: 2 EMYETLGKVGEGSYGTVMKCKH-KNTGQIVAIK-IFYERPEQSVNKIAMREI---KFLKQ 56
+ YE + ++GEG+YG V K + KN G+ VA+K + + E+ + +RE+ + L+
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 57 FHHENLVNLIEVFR-----QKKKIHLVFEFIDH---TVLDELQHYCHGLESKRLRKYLFQ 108
F H N+V L +V ++ K+ LVFE +D T LD++ G+ ++ ++ +FQ
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE--PGVPTETIKDMMFQ 128
Query: 109 ILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRA 168
+LR +D+LHS+ ++HRD+KP+NILV+ SG KL DFG AR + + T V T WYRA
Sbjct: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRA 187
Query: 169 PELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIF 228
PE++L+ +SY PVD+W++GC+ EM P SSD+D L KI+ +G +
Sbjct: 188 PEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--------LP 238
Query: 229 SKSPIFAGVVLP-QVQHPKNAR---KKYPKLNGLLADIVHACLQIDPADRISSSDLLHHE 284
+ V LP Q H K+A+ K ++ L D++ CL +PA RIS+ L H
Sbjct: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298
Query: 285 YF 286
YF
Sbjct: 299 YF 300
>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 171 bits (434), Expect = 1e-42
Identities = 111/302 (36%), Positives = 173/302 (57%), Gaps = 29/302 (9%)
Query: 2 EMYETLGKVGEGSYGTVMKCKH-KNTGQIVAIK-IFYERPEQSVNKIAMREI---KFLKQ 56
+ YE + ++GEG+YG V K + KN G+ VA+K + + E+ + +RE+ + L+
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 57 FHHENLVNLIEVFR-----QKKKIHLVFEFIDH---TVLDELQHYCHGLESKRLRKYLFQ 108
F H N+V L +V ++ K+ LVFE +D T LD++ G+ ++ ++ +FQ
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE--PGVPTETIKDMMFQ 128
Query: 109 ILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRA 168
+LR +D+LHS+ ++HRD+KP+NILV+ SG KL DFG AR + + T V T WYRA
Sbjct: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRA 187
Query: 169 PELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIF 228
PE++L+ +SY PVD+W++GC+ EM P SSD+D L KI+ +G +
Sbjct: 188 PEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--------LP 238
Query: 229 SKSPIFAGVVLP-QVQHPKNAR---KKYPKLNGLLADIVHACLQIDPADRISSSDLLHHE 284
+ V LP Q H K+A+ K ++ L D++ CL +PA RIS+ L H
Sbjct: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298
Query: 285 YF 286
YF
Sbjct: 299 YF 300
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 171 bits (432), Expect = 2e-42
Identities = 96/293 (32%), Positives = 161/293 (54%), Gaps = 11/293 (3%)
Query: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 59
+E ++ L ++ EG+YG V + K K T +IVA+K + E+ ++ ++REI + + H
Sbjct: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
Query: 60 ENLVNLIEVF--RQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLH 117
N+V + E+ KI++V +++H + ++ ++ + Q+LR + +LH
Sbjct: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 530
Query: 118 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTS 177
N I+HRD+K N+L+S +GI K+ DFG AR +P YT V T WYRAPEL+L
Sbjct: 531 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 590
Query: 178 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 237
Y VD+W++GC+ E+ T P P S++D ++K+ +G S + +S+ P +
Sbjct: 591 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 650
Query: 238 VLPQVQHPKNARKKYPKLNGLLA----DIVHACLQIDPADRISSSDLLHHEYF 286
+HP N +K + LL+ D+++ L P RIS+ D L HEYF
Sbjct: 651 TFS--EHPYNNLRK--RFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 699
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,764,480
Number of Sequences: 37866
Number of extensions: 1047649
Number of successful extensions: 5893
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 746
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 3433
Number of HSP's gapped (non-prelim): 1177
length of query: 592
length of database: 18,247,518
effective HSP length: 108
effective length of query: 484
effective length of database: 14,157,990
effective search space: 6852467160
effective search space used: 6852467160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.