BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] (1162 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] 2401 0.0 gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [... 1116 0.0 gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 823 0.0 gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi... 294 3e-79 gi|32698700 PHD finger protein 8 [Homo sapiens] 283 5e-76 gi|90093355 jumonji C domain containing histone demethylase 1 ho... 265 1e-70 gi|117190342 PHD finger protein 2 [Homo sapiens] 237 4e-62 gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 65 4e-10 gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 65 4e-10 gi|156142182 CXXC finger 1 (PHD domain) isoform 1 [Homo sapiens] 60 1e-08 gi|156142180 CXXC finger 1 (PHD domain) isoform 2 [Homo sapiens] 60 1e-08 gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Ho... 60 2e-08 gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo... 60 2e-08 gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 57 1e-07 gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 55 5e-07 gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 54 9e-07 gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 54 9e-07 gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ... 54 9e-07 gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 54 9e-07 gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ... 53 1e-06 gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ... 52 3e-06 gi|21464119 methyl-CpG binding domain protein 1 isoform PCM1 [Ho... 52 3e-06 gi|21464117 methyl-CpG binding domain protein 1 isoform 1 [Homo ... 52 3e-06 gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] 52 4e-06 gi|21464115 methyl-CpG binding domain protein 1 isoform 2 [Homo ... 51 6e-06 gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] 45 3e-04 gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] 45 3e-04 gi|116268091 PHD finger protein 23 [Homo sapiens] 43 0.002 gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 42 0.004 gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 42 0.004 >gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] Length = 1162 Score = 2401 bits (6223), Expect = 0.0 Identities = 1162/1162 (100%), Positives = 1162/1162 (100%) Query: 1 MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK 60 MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK Sbjct: 1 MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK 60 Query: 61 DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE 120 DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE Sbjct: 61 DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE 120 Query: 121 MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES 180 MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES Sbjct: 121 MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES 180 Query: 181 QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN 240 QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN Sbjct: 181 QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN 240 Query: 241 LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL 300 LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL Sbjct: 241 LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL 300 Query: 301 HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS 360 HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS Sbjct: 301 HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS 360 Query: 361 MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT 420 MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT Sbjct: 361 MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT 420 Query: 421 LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT 480 LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT Sbjct: 421 LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT 480 Query: 481 GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP 540 GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP Sbjct: 481 GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP 540 Query: 541 HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM 600 HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM Sbjct: 541 HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM 600 Query: 601 KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG 660 KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG Sbjct: 601 KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG 660 Query: 661 LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT 720 LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT Sbjct: 661 LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT 720 Query: 721 SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP 780 SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP Sbjct: 721 SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP 780 Query: 781 SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC 840 SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC Sbjct: 781 SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC 840 Query: 841 PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS 900 PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS Sbjct: 841 PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS 900 Query: 901 VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS 960 VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS Sbjct: 901 VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS 960 Query: 961 WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR 1020 WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR Sbjct: 961 WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR 1020 Query: 1021 DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ 1080 DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ Sbjct: 1021 DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ 1080 Query: 1081 SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF 1140 SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF Sbjct: 1081 SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF 1140 Query: 1141 ISDLSINSLYCLSDEKLIQKIS 1162 ISDLSINSLYCLSDEKLIQKIS Sbjct: 1141 ISDLSINSLYCLSDEKLIQKIS 1162 >gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo sapiens] Length = 1265 Score = 1116 bits (2886), Expect = 0.0 Identities = 633/1288 (49%), Positives = 804/1288 (62%), Gaps = 181/1288 (14%) Query: 1 MEPEEERIRYSQRLRGTMRRRY-EDDGISD-DEIEGKRTFDLEEKLHTNKYNANFVTFME 58 ME E++ R RLR R+RY E++ +SD +EI R F LEEKL + Y +FV ME Sbjct: 1 MEAEKDSGR---RLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAME 57 Query: 59 GKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKG 118 GKDFN EY+QR LR PLIF+ DGLGIKMPDPDFTV DVK+ VGSRR+VDVMDVNTQKG Sbjct: 58 GKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKG 117 Query: 119 IEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLK 178 EM+M+Q+ RYYETPE +R+KLYNVISLEFSHT+LE++V+RP+ VD +DWVDNMWP+HLK Sbjct: 118 TEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLK 177 Query: 179 ESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTA 238 E QTE+TNAI EM+YPKV+KYCLMSV+GC+TDFH+DFGGTSVWYH+ +GGK+FWLIPPT Sbjct: 178 EKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTL 237 Query: 239 HNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGN 298 HNL LYE W+LSGKQ DIFLGDRV CQRIELKQGYTF IPSGWIHAVYTP D+LVFGGN Sbjct: 238 HNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGN 297 Query: 299 FLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKES 358 LHSFN+PMQL+IY IEDRTRV KFRYPFYYEMCWYVLERYVYC+T RSHLT+E+Q+ES Sbjct: 298 ILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRES 357 Query: 359 LSMDL----ELNGLESGNG---DEEAVDREPRRLSSR------RSVLTSPVANGVNL--- 402 + +D ++G S + +EEA D++P+ + R P +G Sbjct: 358 MLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTS 417 Query: 403 ----DYDGLGKTCRS--LPSLKKTLAGDSSSDC-SRGSHNGQVWDPQCAPRKD---RQVH 452 D + LGK ++ L LK+TL+ +S S P +P + + H Sbjct: 418 TPSEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTH 477 Query: 453 LTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVP 512 LT FEL+GL+ LV+KLESLP +KKCVP GIED AL+ VK +L+E A+ DP LA+TGVP Sbjct: 478 LTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVP 537 Query: 513 IVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCR 572 +V WPK+ PK R P K + PA + AA+ +GARRRR RCR Sbjct: 538 VVTWPKKT-------PKNRAVGRPKGK---LGPASAVK----LAANRTTAGARRRRTRCR 583 Query: 573 KCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVT------------- 619 KC+AC++ ECG CH+C+DMKKFGGPGRMKQSC++RQC+AP LPH+ Sbjct: 584 KCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTV 643 Query: 620 -------------CSLCGEVDQ------NEETQDFEKKLMECCICNEIVHPGCL--QMDG 658 CS+C E+ E +L C C + H G Q G Sbjct: 644 EEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRG 703 Query: 659 EG----------LLNEELPN---------------CWECPKCYQEDSSEKA--------- 684 G LL E+ N C E P+ ++ S+K Sbjct: 704 PGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRK 763 Query: 685 ------QKRKMEESDEEAVQAKVLRP--------------------LRSCDEPLTPPPHS 718 +K++ E +E K L+P + ++PL Sbjct: 764 SDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQE 823 Query: 719 PTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFK----------RRQLLR---- 764 P L SSP AGPS + +E+ K ++L R Sbjct: 824 PEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSK 883 Query: 765 -----LQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKL 819 +Q TE ++ E + + E SE E+ K R + R +K L+GT + Sbjct: 884 ELNHEIQRTENSLANENQQPIKSEPE-SEGEEPK-RPPGICERPHRFSKGLNGTPRELRH 941 Query: 820 QAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLN 879 Q +LR PRV+ + P+ +P + + E + + L+ Sbjct: 942 QL----GPSLRSPPRVISRPPPSVSPPKCIQM--------ERHVIRPPPISPPPDSLPLD 989 Query: 880 GRGSWAQDGDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCK 939 DG M REVWM+VF YLS ++LC CMRVC+TW +WCCDKRLWT+IDL+ CK Sbjct: 990 -------DGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCK 1042 Query: 940 AIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSS 999 +I P LSGII+RQPVSLDLSWTNISKKQL+WL+NRLPGL+DL+L+GCSW AVSAL +SS Sbjct: 1043 SITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSS 1102 Query: 1000 CPLLRTLDLRWAVGIKDPQIRDLLTPPAD-KPGQ-DNRSKLRNMTDFRLAGLDITDATLR 1057 CPLLRTLD++W G+KD Q+RDLL+PP D +PGQ DNRSKLRN+ + RLAGLDITDA+LR Sbjct: 1103 CPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLR 1162 Query: 1058 LIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRR 1117 LIIRHMPLLS+L LS+C+H+TDQS NLLTAVG++TR SLTE+N++ CNK+TDQ L + +R Sbjct: 1163 LIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKR 1222 Query: 1118 IANVTLIDLRGCKQITRKACEHFISDLS 1145 N+ IDLR CKQ+T++ CE FI+++S Sbjct: 1223 CGNICHIDLRYCKQVTKEGCEQFIAEMS 1250 >gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo sapiens] Length = 1336 Score = 823 bits (2125), Expect = 0.0 Identities = 415/702 (59%), Positives = 513/702 (73%), Gaps = 48/702 (6%) Query: 19 RRRY-EDDGISD-DEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPL 76 R+RY E++ +SD +EI R F LEEKL + Y +FV MEGKDFN EY+QR LR PL Sbjct: 47 RQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPL 106 Query: 77 IFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEE 136 IF+ DGLGIKMPDPDFTV DVK+ VGSRR+VDVMDVNTQKG EM+M+Q+ RYYETPE + Sbjct: 107 IFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQ 166 Query: 137 REKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKV 196 R+KLYNVISLEFSHT+LE++V+RP+ VD +DWVDNMWP+HLKE QTE+TNAI EM+YPKV Sbjct: 167 RDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKV 226 Query: 197 QKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDI 256 +KYCLMSV+GC+TDFH+DFGGTSVWYH+ +GGK+FWLIPPT HNL LYE W+LSGKQ DI Sbjct: 227 KKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDI 286 Query: 257 FLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIED 316 FLGDRV CQRIELKQGYTF IPSGWIHAVYTP D+LVFGGN LHSFN+PMQL+IY IED Sbjct: 287 FLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIED 346 Query: 317 RTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDL----ELNGLESGN 372 RTRV KFRYPFYYEMCWYVLERYVYC+T RSHLT+E+Q+ES+ +D ++G S + Sbjct: 347 RTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDS 406 Query: 373 G---DEEAVDREPRRLSSR------RSVLTSPVANG-------VNLDYDGLGKTCR--SL 414 +EEA D++P+ + R P +G + D + LGK + +L Sbjct: 407 WLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPAL 466 Query: 415 PSLKKTLAGDSSSDC-SRGSHNGQVWDPQCAPRKD---RQVHLTHFELEGLRCLVDKLES 470 LK+TL+ +S S P +P + + HLT FEL+GL+ LV+KLES Sbjct: 467 RFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLES 526 Query: 471 LPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKV 530 LP +KKCVP GIED AL+ VK +L+E A+ DP LA+TGVP+V WPK+ PK Sbjct: 527 LPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKK-------TPKN 579 Query: 531 RVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRD 590 R P K + PA + AA+ +GARRRR RCRKC+AC++ ECG CH+C+D Sbjct: 580 RAVGRPKGK---LGPASAV----KLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKD 632 Query: 591 MKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKK----LMECCICN 646 MKKFGGPGRMKQSC++RQC+AP LPH+ C +CGE + + ++ E K LMEC ICN Sbjct: 633 MKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICN 692 Query: 647 EIVHPGCLQM-DGEGLLNEELPNCWECPKCYQEDSSEKAQKR 687 EI+HPGCL++ + EG++N+ELPNCWECPKC + K QKR Sbjct: 693 EIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGK-QKR 733 Score = 405 bits (1041), Expect = e-112 Identities = 235/508 (46%), Positives = 320/508 (62%), Gaps = 53/508 (10%) Query: 677 QEDSSEKAQKRKMEESDEEAVQAKVLRPLRSC-DEPLTPPPHSPTSMLQLIHDPVSPRGM 735 +ED + ++R + +++ A +PLR EP P +P + H Sbjct: 860 KEDKLFRKKRRSWKNAEDRMALAN--KPLRRFKQEPEDELPEAPPKTRESDHS------- 910 Query: 736 VTRSSPGAGPSDHHSASRDERFK----------RRQLLR---------LQATERTMVREK 776 SSP AGPS + +E+ K ++L R +Q TE ++ E Sbjct: 911 -RSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANEN 969 Query: 777 ENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVL 836 + + E SE E+ K R + R +K L+GT + Q +LR PRV+ Sbjct: 970 QQPIKSEPE-SEGEEPK-RPPGICERPHRFSKGLNGTPRELRHQL----GPSLRSPPRVI 1023 Query: 837 VQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQRE 896 + P+ +P + + E + + L+ DG M RE Sbjct: 1024 SRPPPSVSPPKCIQM--------ERHVIRPPPISPPPDSLPLD-------DGAAHVMHRE 1068 Query: 897 VWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVS 956 VWM+VF YLS ++LC CMRVC+TW +WCCDKRLWT+IDL+ CK+I P LSGII+RQPVS Sbjct: 1069 VWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVS 1128 Query: 957 LDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKD 1016 LDLSWTNISKKQL+WL+NRLPGL+DL+L+GCSW AVSAL +SSCPLLRTLD++W G+KD Sbjct: 1129 LDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKD 1188 Query: 1017 PQIRDLLTPPAD-KPGQ-DNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHC 1074 Q+RDLL+PP D +PGQ DNRSKLRN+ + RLAGLDITDA+LRLIIRHMPLLS+L LS+C Sbjct: 1189 AQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYC 1248 Query: 1075 SHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITR 1134 +H+TDQS NLLTAVG++TR SLTE+N++ CNK+TDQ L + +R N+ IDLR CKQ+T+ Sbjct: 1249 NHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTK 1308 Query: 1135 KACEHFISDLSINSLYCLSDEKLIQKIS 1162 + CE FI+++S++ + +EKL+QK+S Sbjct: 1309 EGCEQFIAEMSVSVQFGQVEEKLLQKLS 1336 >gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapiens] Length = 694 Score = 294 bits (753), Expect = 3e-79 Identities = 143/277 (51%), Positives = 197/277 (71%), Gaps = 3/277 (1%) Query: 888 GDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALS 947 G + + R W+ VF++L RELC CMRVC+TW +WC DKRLW ++DLSR K++ P LS Sbjct: 419 GSDHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLS 478 Query: 948 GIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLD 1007 G+++RQP +LDLSWT +SKKQL WL+NRL GL++L+L+GCSW +VSAL ++ P LR LD Sbjct: 479 GVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLD 538 Query: 1008 LRWAVGIKDPQIRDLLTPPAD-KPGQ-DNRSKLRNMTDFRLAGLDITDATLRLIIRHMPL 1065 LRW +KD Q+R+LL PP D KPGQ ++R +L+ + + RLAGL++TDA+LRL++RH P Sbjct: 539 LRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQ 598 Query: 1066 LSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLID 1125 LS LDLSHC+H+ D S +LLTA S R +L LN+AGC++LTD L RR + +D Sbjct: 599 LSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLD 658 Query: 1126 LRGCKQITRKACEHFISDLSINSLYCLSDEKLIQKIS 1162 LR C+Q++ +AC + C +EKL+ K S Sbjct: 659 LRSCRQLSPEACARLAAAGPPGPFRC-PEEKLLLKDS 694 Score = 198 bits (504), Expect = 2e-50 Identities = 96/182 (52%), Positives = 123/182 (67%), Gaps = 13/182 (7%) Query: 545 PAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSC 604 P+ LTP +++ +GARRRR RCR+C+ACV+ ECG CH+CRDMKKFGGPGRMKQSC Sbjct: 13 PSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSC 72 Query: 605 VLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKK----LMECCICNEIVHPGCLQM-DGE 659 +LRQC AP LPH+ C LCGE + + + E+K LMEC ICNEIVHPGCL+M E Sbjct: 73 LLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAE 132 Query: 660 GLLNEELPNCWECPKCYQE-----DSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTP 714 G++N E+PNCWECP+C QE DS E +R+ + +E A + + +EP P Sbjct: 133 GVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEE---GASLGSGWKLTEEPPLP 189 Query: 715 PP 716 PP Sbjct: 190 PP 191 >gi|32698700 PHD finger protein 8 [Homo sapiens] Length = 1024 Score = 283 bits (725), Expect = 5e-76 Identities = 140/303 (46%), Positives = 183/303 (60%), Gaps = 14/303 (4%) Query: 34 GKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDF 93 G TF E + T + + G VE+++ P++ DGLG+ +P P F Sbjct: 83 GSPTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSF 142 Query: 94 TVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRL 153 TV DV+ VGS + +DV+DV Q +M + + +YY + + REK+ NVISLEFS TRL Sbjct: 143 TVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYYSGK--REKVLNVISLEFSDTRL 200 Query: 154 ENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHV 213 N+V+ P V + WV+N+WP + P VQKYCLMSVR YTDFH+ Sbjct: 201 SNLVETPKIVRKLSWVENLWPEECV------------FERPNVQKYCLMSVRDSYTDFHI 248 Query: 214 DFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQG 273 DFGGTSVWYH+ +G K+F+LI PT NL L+E W S Q ++F GD+V C + +KQG Sbjct: 249 DFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKCYKCSVKQG 308 Query: 274 YTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMC 333 T IP+GWIHAV TP D L FGGNFLHS NI MQLK Y IE R + FR+P + +C Sbjct: 309 QTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETIC 368 Query: 334 WYV 336 WYV Sbjct: 369 WYV 371 >gi|90093355 jumonji C domain containing histone demethylase 1 homolog D [Homo sapiens] Length = 941 Score = 265 bits (678), Expect = 1e-70 Identities = 131/315 (41%), Positives = 186/315 (59%), Gaps = 19/315 (6%) Query: 24 DDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDG 83 DDG S G RTF E + + M G Y+++ G P++ D Sbjct: 109 DDG-SKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDD 167 Query: 84 LGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNV 143 LG+++P P F+V DV+ VG +++DV+DV Q +MT+ + +Y+ P R K+ NV Sbjct: 168 LGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPN--RPKVLNV 225 Query: 144 ISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPK--VQKYCL 201 ISLEFS T++ +V+ P + WV+N WP + +PK VQKYCL Sbjct: 226 ISLEFSDTKMSELVEVPDIAKKLSWVENYWPD--------------DSVFPKPFVQKYCL 271 Query: 202 MSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDR 261 M V+ YTDFH+DFGGTSVWYH+ G K+F+LI PT NL YE+W S Q ++F GD+ Sbjct: 272 MGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEVFFGDK 331 Query: 262 VSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVP 321 V C + +KQG+T +P+GWIHAV T D + FGGNFLH+ NI MQL+ Y +E R + P Sbjct: 332 VDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTP 391 Query: 322 NKFRYPFYYEMCWYV 336 + F++PF+ +CW+V Sbjct: 392 DLFKFPFFEAICWFV 406 >gi|117190342 PHD finger protein 2 [Homo sapiens] Length = 1096 Score = 237 bits (605), Expect = 4e-62 Identities = 116/303 (38%), Positives = 174/303 (57%), Gaps = 14/303 (4%) Query: 34 GKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDF 93 G + F E + T + V + G + Y++ G +P++ DGLG+ +P P F Sbjct: 85 GSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTF 144 Query: 94 TVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRL 153 V+DV+ VG R VDV DV QK +M + ++ YY + R+++ NV +LEFS TR+ Sbjct: 145 YVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTN--RKRVLNVTNLEFSDTRM 202 Query: 154 ENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHV 213 + V+ P V + WV+N WP +A+L PKV KYCL+ V+ YTDFH+ Sbjct: 203 SSFVEPPDIVKKLSWVENYWP----------DDALLAK--PKVTKYCLICVKDSYTDFHI 250 Query: 214 DFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQG 273 D GG S WYH+ +G K F+LI P + N+ LYE W + ++F D+V C + +KQG Sbjct: 251 DSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQG 310 Query: 274 YTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMC 333 T IPSGWI+A TP D L F G+FLHS ++ MQ++ Y +E R ++ + ++P + C Sbjct: 311 QTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETAC 370 Query: 334 WYV 336 WY+ Sbjct: 371 WYM 373 >gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] Length = 436 Score = 65.1 bits (157), Expect = 4e-10 Identities = 70/264 (26%), Positives = 110/264 (41%), Gaps = 50/264 (18%) Query: 917 CKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPV--SLDLSWTN-ISKKQLTWLV 973 C + K+C R +DL+ C +I +L + + P+ L++SW + ++K + LV Sbjct: 135 CTSLSKFCSKLR---HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV 191 Query: 974 NRLPGLKDLLLAGCSWSAVSALST--SSCPLLRTLDLRWAVGIKD--------------- 1016 GLK L L GC+ AL + CP L TL+L+ + I D Sbjct: 192 RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQS 251 Query: 1017 ---------------------PQIRDLLTPPADKPGQDNRSKL-RNMTDFRLAGLD---- 1050 P++R L + + L RN + L+ Sbjct: 252 LCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQ 311 Query: 1051 ITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQ 1110 ITD+TL + H P L L LSHC +TD L G+ L + + C +TD Sbjct: 312 ITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHL-GNGACAHDQLEVIELDNCPLITDA 370 Query: 1111 TLIYLRRIANVTLIDLRGCKQITR 1134 +L +L+ ++ I+L C+QITR Sbjct: 371 SLEHLKSCHSLERIELYDCQQITR 394 Score = 53.1 bits (126), Expect = 1e-06 Identities = 68/298 (22%), Positives = 121/298 (40%), Gaps = 37/298 (12%) Query: 893 MQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDL-SRCKAIVPQALSGIIK 951 + +E+ + +F +L LC C +V + W D W +IDL + I + + I K Sbjct: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISK 87 Query: 952 R-----QPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSS--CPLLR 1004 R + +SL + L ++ L L GC+ + + ++ S C LR Sbjct: 88 RCGGFLRKLSL-RGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLR 146 Query: 1005 TLDLRWAVGIKD----------PQIRDLLTPPADKPGQDN-RSKLRNMTDFRLAGL---- 1049 LDL I + P + L D+ +D ++ +R + L Sbjct: 147 HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCT 206 Query: 1050 DITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTD 1109 + D L+ I H P L L+L C +TD+ L+T + L L +GC+ +TD Sbjct: 207 QLEDEALKYIGAHCPELVTLNLQTCLQITDE--GLITICRGC--HKLQSLCASGCSNITD 262 Query: 1110 QTLIYL-RRIANVTLIDLRGCKQIT-------RKACEHFISDLSINSLYCLSDEKLIQ 1159 L L + + ++++ C Q+T + C H + + + ++D LIQ Sbjct: 263 AILNALGQNCPRLRILEVARCSQLTDVGFTTLARNC-HELEKMDLEECVQITDSTLIQ 319 >gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] Length = 491 Score = 65.1 bits (157), Expect = 4e-10 Identities = 69/278 (24%), Positives = 114/278 (41%), Gaps = 41/278 (14%) Query: 899 MSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKR-----Q 953 + +F +L +LC C RVC+ WY D RLW I L+ V +AL + +R Sbjct: 123 VQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTP 182 Query: 954 PVSLDLSWTNIS------KKQLTWLVNRLPGLKDLLLAGCSWSAVSAL--STSSCPLLRT 1005 V L L +S + L + P L+ L ++GC + A+ S CP L Sbjct: 183 NVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEH 242 Query: 1006 LDLRWAVGIKDPQI-RDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMP 1064 LD+ + + R+ + G+ + +MTD + + D L I H Sbjct: 243 LDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFV----LEDEGLHTIAAHCT 298 Query: 1065 LLSRLDLSHCSHLTDQSSNLLTAVGSSTR------------YSLTE----------LNMA 1102 L+ L L C LTD+ L +S + + L E L++A Sbjct: 299 QLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIA 358 Query: 1103 GCNKLTDQTLIYLRR-IANVTLIDLRGCKQITRKACEH 1139 C ++TD + Y+ + + + ++ RGC+ IT E+ Sbjct: 359 HCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEY 396 >gi|156142182 CXXC finger 1 (PHD domain) isoform 1 [Homo sapiens] Length = 660 Score = 60.1 bits (144), Expect = 1e-08 Identities = 31/72 (43%), Positives = 41/72 (56%), Gaps = 4/72 (5%) Query: 540 PHTMKPAPRLTPVRPAAASPIVSGARRRRVR-CRKCKACVQGE-CGVCHYCRDMKKFGGP 597 PH P P + P+ +R R C +C+AC + E CG C +CRDMKKFGGP Sbjct: 139 PHKSSPQPLVAT--PSQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGP 196 Query: 598 GRMKQSCVLRQC 609 +++Q C LRQC Sbjct: 197 NKIRQKCRLRQC 208 >gi|156142180 CXXC finger 1 (PHD domain) isoform 2 [Homo sapiens] Length = 656 Score = 60.1 bits (144), Expect = 1e-08 Identities = 31/72 (43%), Positives = 41/72 (56%), Gaps = 4/72 (5%) Query: 540 PHTMKPAPRLTPVRPAAASPIVSGARRRRVR-CRKCKACVQGE-CGVCHYCRDMKKFGGP 597 PH P P + P+ +R R C +C+AC + E CG C +CRDMKKFGGP Sbjct: 139 PHKSSPQPLVAT--PSQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGP 196 Query: 598 GRMKQSCVLRQC 609 +++Q C LRQC Sbjct: 197 NKIRQKCRLRQC 208 >gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Homo sapiens] Length = 1632 Score = 59.7 bits (143), Expect = 2e-08 Identities = 30/68 (44%), Positives = 37/68 (54%), Gaps = 9/68 (13%) Query: 567 RRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEV 626 +R RC C+ C Q ECG C C+DM KFGG GR KQ+C R+C P + E Sbjct: 665 KRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRC--PNMAMK-------EA 715 Query: 627 DQNEETQD 634 D +EE D Sbjct: 716 DDDEEVDD 723 >gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo sapiens] Length = 1616 Score = 59.7 bits (143), Expect = 2e-08 Identities = 30/68 (44%), Positives = 37/68 (54%), Gaps = 9/68 (13%) Query: 567 RRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEV 626 +R RC C+ C Q ECG C C+DM KFGG GR KQ+C R+C P + E Sbjct: 649 KRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRC--PNMAMK-------EA 699 Query: 627 DQNEETQD 634 D +EE D Sbjct: 700 DDDEEVDD 707 >gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] Length = 423 Score = 57.0 bits (136), Expect = 1e-07 Identities = 68/261 (26%), Positives = 103/261 (39%), Gaps = 53/261 (20%) Query: 933 IDLSRCKAIVPQALSGIIK--RQPVSLDLSWTN-ISKKQLTWLVNRLPGLKDLLLAGCSW 989 +DL+ C +I +L GI + R L+LSW + I+K + LV GLK LLL GC+ Sbjct: 135 LDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQ 194 Query: 990 ---------------------------------------SAVSALSTSSCPLLRTLDLRW 1010 + AL S C L L Sbjct: 195 LEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDASLT- 253 Query: 1011 AVGIKDPQIRDLLTPPADKPGQDNRSKL-RNMTDFRLAGLD----ITDATLRLIIRHMPL 1065 A+G+ P+++ L + L RN + L+ ITD+TL + H P Sbjct: 254 ALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPK 313 Query: 1066 LSRLDLSHCSHLTDQSSNLLTAVGSST--RYSLTELNMAGCNKLTDQTLIYLRRIANVTL 1123 L L LSHC +TD + + +ST L L + C +TD L +L + Sbjct: 314 LQALSLSHCELITDDG---ILHLSNSTCGHERLRVLELDNCLLITDVALEHLENCRGLER 370 Query: 1124 IDLRGCKQITRKACEHFISDL 1144 ++L C+Q+TR + + L Sbjct: 371 LELYDCQQVTRAGIKRMRAQL 391 Score = 55.5 bits (132), Expect = 3e-07 Identities = 63/275 (22%), Positives = 105/275 (38%), Gaps = 69/275 (25%) Query: 893 MQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKR 952 + +E+ + +F +L LC C ++ K W D W +IDL + V + Sbjct: 15 LPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRVV----- 69 Query: 953 QPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAV 1012 NISK+ C LR L LR + Sbjct: 70 ---------ENISKR-------------------CG------------GFLRKLSLRGCI 89 Query: 1013 GIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAG-LDITDATLRLIIRHMPLLSRLDL 1071 G+ D ++ RN+ L G ITD+T + R L LDL Sbjct: 90 GVGDSSLKTF------------AQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDL 137 Query: 1072 SHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLT-DQTLIYLRRIANVTLIDLRGCK 1130 + C +T+ S L + R +L LN++ C+++T D +R + + LRGC Sbjct: 138 TSCVSITNSS---LKGISEGCR-NLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCT 193 Query: 1131 QITRKACEHF------ISDLSINSLYCLSDEKLIQ 1159 Q+ +A +H + L++ S ++DE ++Q Sbjct: 194 QLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQ 228 >gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo sapiens] Length = 3969 Score = 54.7 bits (130), Expect = 5e-07 Identities = 62/258 (24%), Positives = 98/258 (37%), Gaps = 30/258 (11%) Query: 546 APRLTPVRP-----AAASPIVSGARRRRVRCRKCKAC-VQGECGVCHYCRDMKKFGGPGR 599 AP + P++P A P V RR R RC +C C V +CGVC C D KFGG Sbjct: 1126 APPIKPIKPVTRNKAPQEPPVKKGRRSR-RCGQCPGCQVPEDCGVCTNCLDKPKFGGRNI 1184 Query: 600 MKQSCVLRQC----LAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQ 655 KQ C +R+C P + + + + + +K E + +V Sbjct: 1185 KKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSS--- 1241 Query: 656 MDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPP 715 + P+ E P ++ SSE ++ +EE EE + + P + Sbjct: 1242 -------QKPTPSAREDP-APKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRK 1293 Query: 716 PHSPTSMLQLIHDPVSP-RGMVTRSSPGAGPSDHHS------ASRDERFKRRQLL-RLQA 767 S L+ P P G + P PS+ S E+ K++++ R Sbjct: 1294 SSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSI 1353 Query: 768 TERTMVREKENNPSGKKE 785 + +EKE P K+ Sbjct: 1354 PVKQKPKEKEKPPPVNKQ 1371 Score = 33.1 bits (74), Expect = 1.6 Identities = 34/146 (23%), Positives = 51/146 (34%), Gaps = 32/146 (21%) Query: 564 ARRRRVRCRKCKACVQGEC---------------GVCHYCRDMKKFGG--PGR-----MK 601 A ++ + C KC+ EC +C C K G PG+ Sbjct: 1491 ATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWS 1550 Query: 602 QSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGL 661 L A C LC D+ + D+E K+M+C C+ VH C + E Sbjct: 1551 HDFSLCHDCAKLFAKGNFCPLC---DKCYDDDDYESKMMQCGKCDRWVHSKCENLSDE-- 1605 Query: 662 LNEELPN-----CWECPKCYQEDSSE 682 + E L N + C C + +E Sbjct: 1606 MYEILSNLPESVAYTCVNCTERHPAE 1631 >gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] Length = 418 Score = 53.9 bits (128), Expect = 9e-07 Identities = 64/268 (23%), Positives = 109/268 (40%), Gaps = 34/268 (12%) Query: 896 EVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLW----TKIDLSRCKAIVPQALS--GI 949 E+ +F YL R+ +VC W K +W K+ L R + +L GI Sbjct: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70 Query: 950 IKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGC---SWSAVSALSTSSCPLLRTL 1006 + Q +SL ++ L++++ + ++ L L+GC + + + LR L Sbjct: 71 RRVQILSL--------RRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRAL 122 Query: 1007 DLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGL-DITDATLRLIIRHMPL 1065 +L I D + + L+ + L G +IT+ L LI + Sbjct: 123 NLSLCKQITDSSLGRI------------AQYLKGLEVLELGGCSNITNTGLLLIAWGLQR 170 Query: 1066 LSRLDLSHCSHLTDQSSNLLTAVGSSTR---YSLTELNMAGCNKLTDQTLIYLRR-IANV 1121 L L+L C HL+D L + S L +L + C KLTD +L ++ R + + Sbjct: 171 LKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGL 230 Query: 1122 TLIDLRGCKQITRKACEHFISDLSINSL 1149 L++L C I+ H S+ SL Sbjct: 231 RLLNLSFCGGISDAGLLHLSHMGSLRSL 258 Score = 51.2 bits (121), Expect = 6e-06 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 39/199 (19%) Query: 962 TNISKKQLTWLVNRLPGLKDLLLAGCSW-SAVSALSTSSCPLLRTLDLRWAVGIKDPQIR 1020 T++S K ++ L GL+ L L+ C S L S LR+L+LR I D I Sbjct: 216 TDLSLKHIS---RGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIM 272 Query: 1021 DLLTPPADKPGQDNRSKLRNMTDFRLAGLDIT------DATLRLIIRHMPLLSRLDLSHC 1074 L M RL+GLD++ D +L I + + L L L C Sbjct: 273 HLA-----------------MGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSC 315 Query: 1075 SHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTL-IYLRRIANVTLIDLRGCKQIT 1133 H++D N + + L LN+ C ++TD+ L + ++ +T IDL GC +IT Sbjct: 316 -HISDDGINRMVR----QMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRIT 370 Query: 1134 RKACEHFISDLSINSLYCL 1152 ++ E I L CL Sbjct: 371 KRGLER------ITQLPCL 383 >gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 [Homo sapiens] Length = 690 Score = 53.9 bits (128), Expect = 9e-07 Identities = 71/284 (25%), Positives = 106/284 (37%), Gaps = 71/284 (25%) Query: 889 DESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSG 948 D S + + +F YLS +++ C +V W LW ID S K ++P Sbjct: 154 DISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKY-- 211 Query: 949 IIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDL 1008 I W +N L L GC + S S C L+ L++ Sbjct: 212 ---------------IVSTLQRWRLNVL----RLNFRGCLLRPKTFRSVSHCRNLQELNV 252 Query: 1009 RWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSR 1068 D +R + PG + L+ IT+ T+RL+ RH L Sbjct: 253 SDCPTFTDESMRHI---SEGCPG---------VLCLNLSNTTITNRTMRLLPRHFHNLQN 300 Query: 1069 LDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMA-GCNKLTDQTLIYLRRIANVTLIDLR 1127 L L++C TD+ L LN+ GC+K LIYL DL Sbjct: 301 LSLAYCRRFTDK--------------GLQYLNLGNGCHK-----LIYL---------DLS 332 Query: 1128 GCKQITRKACEHF------ISDLSINSLYCLSD---EKLIQKIS 1162 GC QI+ + + I L+IN + L+D + L++K S Sbjct: 333 GCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCS 376 Score = 46.2 bits (108), Expect = 2e-04 Identities = 54/224 (24%), Positives = 94/224 (41%), Gaps = 44/224 (19%) Query: 955 VSLDLSW-TNISKKQLTWLVNRLPGLKDLLLAGCSW---SAVSALSTSSCPLLRTLDLRW 1010 + LDLS T IS + ++ N G+ L + + V AL C + +L Sbjct: 327 IYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKAL-VEKCSRITSLVFTG 385 Query: 1011 AVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLD-ITDATLRLIIRHMPLLSRL 1069 A I D R L + KLR + R G +TDA+ + I ++ P LS + Sbjct: 386 APHISDCTFRAL-----------SACKLRKI---RFEGNKRVTDASFKFIDKNYPNLSHI 431 Query: 1070 DLSHCSHLTDQSSNLLTAVGSSTRYSLT-----------------------ELNMAGCNK 1106 ++ C +TD S L+ + T +L ELN++ C + Sbjct: 432 YMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVR 491 Query: 1107 LTDQTLIYL-RRIANVTLIDLRGCKQITRKACEHFISDLSINSL 1149 L+D +++ L R N+ + LR C+ +T + + ++ S+ S+ Sbjct: 492 LSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSI 535 Score = 42.0 bits (97), Expect = 0.003 Identities = 48/195 (24%), Positives = 86/195 (44%), Gaps = 29/195 (14%) Query: 977 PGLKDLLLAGCSWSAVSAL-STSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNR 1035 P L + +A C S+L S S L L+L V I D ++ L PA R Sbjct: 426 PNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASM-----R 480 Query: 1036 SKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYS 1095 + N+++ + ++DA++ + P L+ L L +C HLT Q + + +S Sbjct: 481 IRELNLSNC----VRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNI-----FS 531 Query: 1096 LTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCK-------QITRKACE------HFIS 1142 L ++++G + ++++ L L R + + + C QIT A E H++ Sbjct: 532 LVSIDLSGTD-ISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLH 590 Query: 1143 DLSINSLYCLSDEKL 1157 L I+ L+D+ L Sbjct: 591 ILDISGCVLLTDQIL 605 >gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 [Homo sapiens] Length = 735 Score = 53.9 bits (128), Expect = 9e-07 Identities = 71/284 (25%), Positives = 106/284 (37%), Gaps = 71/284 (25%) Query: 889 DESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSG 948 D S + + +F YLS +++ C +V W LW ID S K ++P Sbjct: 154 DISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKY-- 211 Query: 949 IIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDL 1008 I W +N L L GC + S S C L+ L++ Sbjct: 212 ---------------IVSTLQRWRLNVL----RLNFRGCLLRPKTFRSVSHCRNLQELNV 252 Query: 1009 RWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSR 1068 D +R + PG + L+ IT+ T+RL+ RH L Sbjct: 253 SDCPTFTDESMRHI---SEGCPG---------VLCLNLSNTTITNRTMRLLPRHFHNLQN 300 Query: 1069 LDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMA-GCNKLTDQTLIYLRRIANVTLIDLR 1127 L L++C TD+ L LN+ GC+K LIYL DL Sbjct: 301 LSLAYCRRFTDK--------------GLQYLNLGNGCHK-----LIYL---------DLS 332 Query: 1128 GCKQITRKACEHF------ISDLSINSLYCLSD---EKLIQKIS 1162 GC QI+ + + I L+IN + L+D + L++K S Sbjct: 333 GCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCS 376 Score = 46.2 bits (108), Expect = 2e-04 Identities = 54/224 (24%), Positives = 94/224 (41%), Gaps = 44/224 (19%) Query: 955 VSLDLSW-TNISKKQLTWLVNRLPGLKDLLLAGCSW---SAVSALSTSSCPLLRTLDLRW 1010 + LDLS T IS + ++ N G+ L + + V AL C + +L Sbjct: 327 IYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKAL-VEKCSRITSLVFTG 385 Query: 1011 AVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLD-ITDATLRLIIRHMPLLSRL 1069 A I D R L + KLR + R G +TDA+ + I ++ P LS + Sbjct: 386 APHISDCTFRAL-----------SACKLRKI---RFEGNKRVTDASFKFIDKNYPNLSHI 431 Query: 1070 DLSHCSHLTDQSSNLLTAVGSSTRYSLT-----------------------ELNMAGCNK 1106 ++ C +TD S L+ + T +L ELN++ C + Sbjct: 432 YMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVR 491 Query: 1107 LTDQTLIYL-RRIANVTLIDLRGCKQITRKACEHFISDLSINSL 1149 L+D +++ L R N+ + LR C+ +T + + ++ S+ S+ Sbjct: 492 LSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSI 535 Score = 46.2 bits (108), Expect = 2e-04 Identities = 57/249 (22%), Positives = 102/249 (40%), Gaps = 28/249 (11%) Query: 905 LSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAI----VPQALSGIIKRQPVSLDLS 960 LS + +C + + + + T ++L+ C I + Q L G + L+LS Sbjct: 428 LSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLS 487 Query: 961 -WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQI 1019 +S + L R P L + LS +C L + + V I Sbjct: 488 NCVRLSDASVMKLSERCPNL-------------NYLSLRNCEHLTAQGIGYIVNIFSLVS 534 Query: 1020 RDLLTPPADKPGQDNRSKLRNMTDFRLAGL-DITDATLRLIIRHMPLLSRLDLSHCSHLT 1078 DL G + S+ + + + ++ ITD ++ + +L LD+S+CS L+ Sbjct: 535 IDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLS 594 Query: 1079 DQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYL-RRIANVTLIDLRGCKQITRKAC 1137 D L +LT L++AGC K+TD + L + + ++D+ GC +T Sbjct: 595 DMIIKALAIYC----INLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLT---- 646 Query: 1138 EHFISDLSI 1146 + + DL I Sbjct: 647 DQILEDLQI 655 Score = 42.4 bits (98), Expect = 0.003 Identities = 53/234 (22%), Positives = 92/234 (39%), Gaps = 62/234 (26%) Query: 977 PGLKDLLLAGCSWSAVSAL-STSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNR 1035 P L + +A C S+L S S L L+L V I D ++ L PA R Sbjct: 426 PNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASM-----R 480 Query: 1036 SKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGS----- 1090 + N+++ + ++DA++ + P L+ L L +C HLT Q + + S Sbjct: 481 IRELNLSNC----VRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSID 536 Query: 1091 --------------STRYSLTELNMAGCNKLTDQTL-----------------------I 1113 S L EL+++ C ++TD + + Sbjct: 537 LSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDM 596 Query: 1114 YLRRIA----NVTLIDLRGCKQITRKACE------HFISDLSINSLYCLSDEKL 1157 ++ +A N+T + + GC +IT A E H++ L I+ L+D+ L Sbjct: 597 IIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQIL 650 >gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sapiens] Length = 2715 Score = 53.9 bits (128), Expect = 9e-07 Identities = 24/57 (42%), Positives = 31/57 (54%), Gaps = 1/57 (1%) Query: 554 PAAASPIVSGARRRRVRCRKCKACVQ-GECGVCHYCRDMKKFGGPGRMKQSCVLRQC 609 P + P G + R RC C+ C++ +CG C C D KFGGP KQ CV R+C Sbjct: 949 PRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKC 1005 Score = 35.8 bits (81), Expect = 0.24 Identities = 39/167 (23%), Positives = 64/167 (38%), Gaps = 19/167 (11%) Query: 554 PAAASPIVSGARRRRVRCRKCKACVQGE-CGVCHYCRDMKKFGGPGRMKQSCVLRQCLAP 612 PA P R+ R C ACV+ + CG ++ G + C L Sbjct: 1277 PACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTQ---LYE 1333 Query: 613 RLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGE------GLLNEEL 666 + + C+ C E D+E K+M+C C+ VH C + E GL + L Sbjct: 1334 KGNYCPICTRC------YEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVL 1387 Query: 667 PNCWECPKCYQ---EDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDE 710 C C Q ++ A + + + + + +KV+ PL C + Sbjct: 1388 YTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCTQ 1434 >gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo sapiens] Length = 424 Score = 53.1 bits (126), Expect = 1e-06 Identities = 64/292 (21%), Positives = 117/292 (40%), Gaps = 55/292 (18%) Query: 891 SW--MQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSG 948 SW + E+ + +F L EL + VCK WY+ D+ LW +DL+ K + P Sbjct: 96 SWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTG-KNLHPDVTGR 154 Query: 949 IIKR-------------QPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSAL 995 ++ + QP++ S + L+ V + L +L Sbjct: 155 LLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGIL------------ 202 Query: 996 STSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLD-ITDA 1054 S C L+ L L + + DP + L +K N+ L+G ++ Sbjct: 203 --SQCSKLQNLSLE-GLRLSDPIVNTL-------------AKNSNLVRLNLSGCSGFSEF 246 Query: 1055 TLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLI- 1113 L+ ++ L L+LS C T++ + A S T +T+LN++G K ++ + Sbjct: 247 ALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSET---ITQLNLSGYRKNLQKSDLS 303 Query: 1114 -YLRRIANVTLIDLRGCKQITRKACEHF-----ISDLSINSLYCLSDEKLIQ 1159 +RR N+ +DL + + F + LS++ Y + E L++ Sbjct: 304 TLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLE 355 >gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo sapiens] Length = 410 Score = 52.4 bits (124), Expect = 3e-06 Identities = 64/291 (21%), Positives = 116/291 (39%), Gaps = 55/291 (18%) Query: 891 SW--MQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSG 948 SW + E+ + +F L EL + VCK WY+ D+ LW +DL+ K + P Sbjct: 96 SWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTG-KNLHPDVTGR 154 Query: 949 IIKR-------------QPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSAL 995 ++ + QP++ S + L+ V + L +L Sbjct: 155 LLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGIL------------ 202 Query: 996 STSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLD-ITDA 1054 S C L+ L L + + DP + L +K N+ L+G ++ Sbjct: 203 --SQCSKLQNLSLE-GLRLSDPIVNTL-------------AKNSNLVRLNLSGCSGFSEF 246 Query: 1055 TLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLI- 1113 L+ ++ L L+LS C T++ + A S T +T+LN++G K ++ + Sbjct: 247 ALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSET---ITQLNLSGYRKNLQKSDLS 303 Query: 1114 -YLRRIANVTLIDLRGCKQITRKACEHF-----ISDLSINSLYCLSDEKLI 1158 +RR N+ +DL + + F + LS++ Y + E L+ Sbjct: 304 TLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLL 354 >gi|21464119 methyl-CpG binding domain protein 1 isoform PCM1 [Homo sapiens] Length = 556 Score = 52.0 bits (123), Expect = 3e-06 Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 14/90 (15%) Query: 533 PTIPITKPHTMKPAPR-LTPVRPAA----------ASPIVSGARRRRVRCRKCKACVQG- 580 P P P +P PR L P PA P + RR+ +C C AC++ Sbjct: 242 PPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTN--RRQNRKCGACAACLRRM 299 Query: 581 ECGVCHYCRDMKKFGGPGRMKQSCVLRQCL 610 +CG C +C D KFGG + +Q C RQCL Sbjct: 300 DCGRCDFCCDKPKFGGSNQKRQKCRWRQCL 329 >gi|21464117 methyl-CpG binding domain protein 1 isoform 1 [Homo sapiens] Length = 605 Score = 52.0 bits (123), Expect = 3e-06 Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 14/90 (15%) Query: 533 PTIPITKPHTMKPAPR-LTPVRPAA----------ASPIVSGARRRRVRCRKCKACVQG- 580 P P P +P PR L P PA P + RR+ +C C AC++ Sbjct: 291 PPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTN--RRQNRKCGACAACLRRM 348 Query: 581 ECGVCHYCRDMKKFGGPGRMKQSCVLRQCL 610 +CG C +C D KFGG + +Q C RQCL Sbjct: 349 DCGRCDFCCDKPKFGGSNQKRQKCRWRQCL 378 >gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] Length = 479 Score = 51.6 bits (122), Expect = 4e-06 Identities = 79/335 (23%), Positives = 125/335 (37%), Gaps = 93/335 (27%) Query: 901 VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKI--------------------------- 933 +F Y S E C +VCK W + + W + Sbjct: 105 LFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFA 164 Query: 934 -------------DLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLK 980 DL C+ I ALS K+ ++ L + I+ L ++ ++ G+ Sbjct: 165 ARGFEGFCLVGVSDLDICEFIDNYALS---KKGVKAMSLKRSTITDAGLEVMLEQMQGVV 221 Query: 981 DLLLAGCS-------WSAVSA----LSTSSC---------------PLLRTLDLRWAVGI 1014 L L+GC+ WS++SA LS S C P L L L+ A + Sbjct: 222 RLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQ-AYHV 280 Query: 1015 KDPQI--------------RDLLTPPADKPGQDNR-SKLRNMTDFRLAGLD-ITDATLRL 1058 D + R L G N L N+T L+G +TD + L Sbjct: 281 TDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVEL 340 Query: 1059 IIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRI 1118 + ++ L LDLS C +TD + + + L EL + C ++TD L YL + Sbjct: 341 VAENLRKLRSLDLSWCPRITDMALEYVAC----DLHRLEELVLDRCVRITDTGLSYLSTM 396 Query: 1119 ANVTLIDLRGCKQITRKACEHFISDLSINSLYCLS 1153 +++ + LR C Q+ +H L++ SL LS Sbjct: 397 SSLRSLYLRWCCQVQDFGLKHL---LALGSLRLLS 428 >gi|21464115 methyl-CpG binding domain protein 1 isoform 2 [Homo sapiens] Length = 586 Score = 51.2 bits (121), Expect = 6e-06 Identities = 26/67 (38%), Positives = 36/67 (53%), Gaps = 4/67 (5%) Query: 545 PAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQG-ECGVCHYCRDMKKFGGPGRMKQS 603 P P +P P P + RR+ +C C AC++ +CG C +C D KFGG + +Q Sbjct: 292 PPPSQSP-EPTEPQPYTN--RRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQK 348 Query: 604 CVLRQCL 610 C RQCL Sbjct: 349 CRWRQCL 355 >gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] Length = 223 Score = 45.4 bits (106), Expect = 3e-04 Identities = 30/96 (31%), Positives = 49/96 (51%), Gaps = 5/96 (5%) Query: 1050 DITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTD 1109 ++TD L + R P L L LSHCS L+D+ A +S+ L LN++ C++L + Sbjct: 112 ELTDNGLVAVARGCPSLEHLALSHCSRLSDKG----WAQAASSWPRLQHLNLSSCSQLIE 167 Query: 1110 QTLIYL-RRIANVTLIDLRGCKQITRKACEHFISDL 1144 QTL + + + ++D+ C I A F + L Sbjct: 168 QTLDAIGQACRQLRVLDVATCPGINMAAVRRFQAQL 203 Score = 31.6 bits (70), Expect = 4.6 Identities = 28/101 (27%), Positives = 43/101 (42%), Gaps = 27/101 (26%) Query: 1066 LSRLDLSHCSHLTDQSSNLLTAVGSS------------TRYSLTELNMAGCNKLTDQTL- 1112 L+ L L+HCS L + A G+ T +L EL++ C+KLTD +L Sbjct: 35 LASLSLAHCSSLKSRPELEHQASGTKDACPEPQGPSLLTLRALQELDLTACSKLTDASLA 94 Query: 1113 -----IYLRRIANVTLIDL---------RGCKQITRKACEH 1139 + LR+++ L +L RGC + A H Sbjct: 95 KVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135 >gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] Length = 223 Score = 45.4 bits (106), Expect = 3e-04 Identities = 30/96 (31%), Positives = 49/96 (51%), Gaps = 5/96 (5%) Query: 1050 DITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTD 1109 ++TD L + R P L L LSHCS L+D+ A +S+ L LN++ C++L + Sbjct: 112 ELTDNGLVAVARGCPSLEHLALSHCSRLSDKG----WAQAASSWPRLQHLNLSSCSQLIE 167 Query: 1110 QTLIYL-RRIANVTLIDLRGCKQITRKACEHFISDL 1144 QTL + + + ++D+ C I A F + L Sbjct: 168 QTLDAIGQACRQLRVLDVATCPGINMAAVRRFQAQL 203 Score = 31.6 bits (70), Expect = 4.6 Identities = 28/101 (27%), Positives = 43/101 (42%), Gaps = 27/101 (26%) Query: 1066 LSRLDLSHCSHLTDQSSNLLTAVGSS------------TRYSLTELNMAGCNKLTDQTL- 1112 L+ L L+HCS L + A G+ T +L EL++ C+KLTD +L Sbjct: 35 LASLSLAHCSSLKSRPELEHQASGTKDACPEPQGPSLLTLRALQELDLTACSKLTDASLA 94 Query: 1113 -----IYLRRIANVTLIDL---------RGCKQITRKACEH 1139 + LR+++ L +L RGC + A H Sbjct: 95 KVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135 >gi|116268091 PHD finger protein 23 [Homo sapiens] Length = 403 Score = 42.7 bits (99), Expect = 0.002 Identities = 65/291 (22%), Positives = 104/291 (35%), Gaps = 46/291 (15%) Query: 679 DSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHS-----PTSMLQLIHDPVSPR 733 DS+ +K K+++S + KV PL T P + P S L H P Sbjct: 123 DSATLLEKMKLKDSLFDLDGPKVASPLSPTSLTHTSRPPAALTPVPLSQGDLSHPPRKKD 182 Query: 734 GMVTRSSPGAG------------PSDHHSASRDERFKRRQLLRLQATERTMVREKENNP- 780 + PGAG P D SR ++ K+R+L + + +R P Sbjct: 183 RKNRKLGPGAGAGFGVLRRPRPTPGDGEKRSRIKKSKKRKLKKAERGDRLPPPGPPQAPP 242 Query: 781 --SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQ 838 + +E E E+ + TV + G + VP L +PR Sbjct: 243 SDTDSEEEEEEEEEEEEEEMATV--------VGGEAPVPVLPTPP-------EAPRPPAT 287 Query: 839 HCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVW 898 P P E +E E ++ D++ G R+ + GD+SW + Sbjct: 288 VHPEGVPPADSES----KEVGSTETSQDGDASSSEGEMRVMDEDIMVESGDDSWDLITCY 343 Query: 899 MSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKID----LSRCKAIVPQA 945 + + R + EC +C TW C K T + +CK + P+A Sbjct: 344 CR--KPFAGRPMIEC-SLCGTWIHLSCAKIKKTNVPDFFYCQKCKELRPEA 391 >gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3 [Homo sapiens] Length = 2004 Score = 41.6 bits (96), Expect = 0.004 Identities = 38/131 (29%), Positives = 49/131 (37%), Gaps = 23/131 (17%) Query: 601 KQSCVLRQCLAP--RLPHSVT---------CSLC-GEVDQNEETQDFEKKLMECCICNEI 648 K+SC CL P LPH CS C G +QN E + E L+ C C Sbjct: 179 KESCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEE--LISCADCGNS 236 Query: 649 VHPGCLQMDGEGLLNEELP--NCWECPKCYQ-EDSSEKAQKRKMEESDEEAVQAKVLRPL 705 HP CL+ E + + C EC C D + A +S + + Sbjct: 237 GHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFH------M 290 Query: 706 RSCDEPLTPPP 716 CD PLT P Sbjct: 291 ECCDPPLTRMP 301 Score = 30.8 bits (68), Expect = 7.8 Identities = 47/209 (22%), Positives = 85/209 (40%), Gaps = 25/209 (11%) Query: 671 ECPKCYQED---SSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIH 727 E P+C + + S K+ + +E D +V+++ +P E + P + S L H Sbjct: 800 EEPQCQERELEISVGKSVSHENKEQDSYSVESEK-KP-----EVMAPVSSTRLSKQVLPH 853 Query: 728 DPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELS 787 D + +R G + ERF + +L E + +++ G+K + Sbjct: 854 DSLPANSQPSRR----GRWGRKNRKTQERFGDKDS-KLLLEETSSAPQEQYGECGEKSEA 908 Query: 788 EVEKAKIRGSYLTVTLQRPTKELHGTSIVPKL---QAITASSANLRHSPRVL---VQHCP 841 E+ L + ++P+++ G +PK + + L+ SP L + Sbjct: 909 TQEQYTESEEQLVASEEQPSQD--GKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGS 966 Query: 842 ARTPQR---GDEEGLGGEEEEEEEEEEED 867 R P+R GD L G E EEEEE + Sbjct: 967 ERLPRRYSEGDRAVLRGFSESSEEEEEPE 995 >gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3 [Homo sapiens] Length = 2004 Score = 41.6 bits (96), Expect = 0.004 Identities = 38/131 (29%), Positives = 49/131 (37%), Gaps = 23/131 (17%) Query: 601 KQSCVLRQCLAP--RLPHSVT---------CSLC-GEVDQNEETQDFEKKLMECCICNEI 648 K+SC CL P LPH CS C G +QN E + E L+ C C Sbjct: 179 KESCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEE--LISCADCGNS 236 Query: 649 VHPGCLQMDGEGLLNEELP--NCWECPKCYQ-EDSSEKAQKRKMEESDEEAVQAKVLRPL 705 HP CL+ E + + C EC C D + A +S + + Sbjct: 237 GHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFH------M 290 Query: 706 RSCDEPLTPPP 716 CD PLT P Sbjct: 291 ECCDPPLTRMP 301 Score = 30.8 bits (68), Expect = 7.8 Identities = 47/209 (22%), Positives = 85/209 (40%), Gaps = 25/209 (11%) Query: 671 ECPKCYQED---SSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIH 727 E P+C + + S K+ + +E D +V+++ +P E + P + S L H Sbjct: 800 EEPQCQERELEISVGKSVSHENKEQDSYSVESEK-KP-----EVMAPVSSTRLSKQVLPH 853 Query: 728 DPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELS 787 D + +R G + ERF + +L E + +++ G+K + Sbjct: 854 DSLPANSQPSRR----GRWGRKNRKTQERFGDKDS-KLLLEETSSAPQEQYGECGEKSEA 908 Query: 788 EVEKAKIRGSYLTVTLQRPTKELHGTSIVPKL---QAITASSANLRHSPRVL---VQHCP 841 E+ L + ++P+++ G +PK + + L+ SP L + Sbjct: 909 TQEQYTESEEQLVASEEQPSQD--GKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGS 966 Query: 842 ARTPQR---GDEEGLGGEEEEEEEEEEED 867 R P+R GD L G E EEEEE + Sbjct: 967 ERLPRRYSEGDRAVLRGFSESSEEEEEPE 995 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.135 0.418 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 49,821,031 Number of Sequences: 37866 Number of extensions: 2533335 Number of successful extensions: 23891 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 258 Number of HSP's successfully gapped in prelim test: 187 Number of HSP's that attempted gapping in prelim test: 17203 Number of HSP's gapped (non-prelim): 3826 length of query: 1162 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1049 effective length of database: 13,968,660 effective search space: 14653124340 effective search space used: 14653124340 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.