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Search of human proteins with 16306492
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16306492 cell division cycle 2 isoform 2 [Homo sapiens]
(240 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16306492 cell division cycle 2 isoform 2 [Homo sapiens] 484 e-137
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 427 e-120
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 426 e-120
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 271 5e-73
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 264 6e-71
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens] 232 2e-61
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 206 2e-53
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 198 3e-51
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 198 3e-51
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 196 2e-50
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 196 2e-50
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 196 2e-50
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 190 1e-48
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 178 4e-45
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens] 178 4e-45
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 161 5e-40
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 160 7e-40
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 157 1e-38
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 153 1e-37
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 149 2e-36
gi|4502735 cyclin-dependent kinase 4 [Homo sapiens] 144 5e-35
gi|11496279 male germ cell-associated kinase [Homo sapiens] 142 3e-34
gi|27477122 intestinal cell kinase [Homo sapiens] 141 6e-34
gi|7662388 intestinal cell kinase [Homo sapiens] 141 6e-34
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 134 7e-32
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 133 1e-31
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 133 1e-31
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 133 1e-31
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 133 1e-31
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 133 1e-31
>gi|16306492 cell division cycle 2 isoform 2 [Homo sapiens]
Length = 240
Score = 484 bits (1246), Expect = e-137
Identities = 240/240 (100%), Positives = 240/240 (100%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKVVTLWYRSPEVLLG 120
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKVVTLWYRSPEVLLG
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKVVTLWYRSPEVLLG 120
Query: 121 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 180
SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY
Sbjct: 121 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 180
Query: 181 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 240
KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
Sbjct: 181 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 240
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 427 bits (1099), Expect = e-120
Identities = 229/297 (77%), Positives = 232/297 (78%), Gaps = 57/297 (19%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKK---------YLDSIPPGQYM----------- 100
PNIVSLQDVLMQDSRLYLIFEFLSMDLKK Y+DS Y+
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 101 -----------------DSSLVK--------------------VVTLWYRSPEVLLGSAR 123
D +K VVTLWYRSPEVLLGSAR
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180
Query: 124 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 183
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240
Query: 184 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 240
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
Sbjct: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 426 bits (1095), Expect = e-120
Identities = 227/297 (76%), Positives = 232/297 (78%), Gaps = 57/297 (19%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKK---------YLDSIPPGQYM----------- 100
PNIVSLQDVLMQDSRLYLIFEFLSMDLKK Y+DS Y+
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 101 -----------------DSSLVKV--------------------VTLWYRSPEVLLGSAR 123
D +K+ +TLWYRSPEVLLGSAR
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSAR 180
Query: 124 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 183
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240
Query: 184 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 240
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
Sbjct: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 271 bits (692), Expect = 5e-73
Identities = 150/293 (51%), Positives = 181/293 (61%), Gaps = 56/293 (19%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDL-----------------KKYLDSIPPG------ 97
PNIV L DV+ +++LYL+FEFL DL K YL + G
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 98 ---------------------QYMDSSLVK------------VVTLWYRSPEVLLGSARY 124
+ D L + VVTLWYR+PE+LLG Y
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
Query: 125 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 184
ST VDIWS+G IFAE+ T++ LF GDSEIDQLFRIFR LGTP+ VWP V S+ DYK +F
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
Query: 185 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 237
PKW + V LDE+G LLS+ML YDP KRIS K AL HP+F D+ +
Sbjct: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 264 bits (674), Expect = 6e-71
Identities = 146/287 (50%), Positives = 178/287 (62%), Gaps = 56/287 (19%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
M+ + K+EKIGEGTYGVVYK +++ TGQ+VA+KKIRL+ E EGVPSTAIREISLLKEL+H
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDL-----------------KKYLDSIPPG------ 97
PNIV L DV+ + +LYL+FEFLS DL K YL + G
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120
Query: 98 ---------------------QYMDSSLVK------------VVTLWYRSPEVLLGSARY 124
+ D L + VVTLWYR+PE+LLGS Y
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180
Query: 125 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 184
+T VDIWSIG IFAE+ T+K LF GDSEIDQLFRIFR LGTP+ + WP V L DYK +F
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSF 240
Query: 185 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 231
PKW L V NL+ G DLL ++L YDP++RI+ K AL HPYF+
Sbjct: 241 PKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFS 287
>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
Length = 264
Score = 232 bits (591), Expect = 2e-61
Identities = 130/259 (50%), Positives = 169/259 (65%), Gaps = 22/259 (8%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKVV-------- 108
PNIV L DV+ +++LYL+FEFL DLKK++D+ P + S L +++
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 109 -TLWYR--SPEVLLGSARYSTPVDIWSIGTIF-------AELATKKPLFHGDSEIDQLFR 158
+ +R P+ LL + + + + + F T++ LF GDSEIDQLFR
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFR 180
Query: 159 IFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKR 218
IFR LGTP+ VWP V S+ DYK +FPKW + V LDE+G LLS+ML YDP KR
Sbjct: 181 IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 240
Query: 219 ISGKMALNHPYFNDLDNQI 237
IS K AL HP+F D+ +
Sbjct: 241 ISAKAALAHPFFQDVTKPV 259
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 206 bits (523), Expect = 2e-53
Identities = 122/297 (41%), Positives = 166/297 (55%), Gaps = 65/297 (21%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
ME Y K+EK+GEGTY VYKGR K T +VA+K+IRLE EEG P TAIRE+SLLK+L+H
Sbjct: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 247
Query: 61 PNIVSLQDVL-----------------------------MQDSRLYLIF----------- 80
NIV+L D++ M + +L+L
Sbjct: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRR 307
Query: 81 EFLSMDLK------------KYLD-------SIPPGQYMDSSLVKVVTLWYRSPEVLLGS 121
+ L DLK K D S+P Y + +VVTLWYR P+VLLGS
Sbjct: 308 KVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSN----EVVTLWYRPPDVLLGS 363
Query: 122 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 181
+ YST +D+W +G IF E+A+ +PLF G + D+L IFR LGTP+ E WP + S +++K
Sbjct: 364 SEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFK 423
Query: 182 N-TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 237
N FPK+KP L +H LD G++L++K L Y+ KR+S + A+ H YF L +I
Sbjct: 424 NYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 198 bits (504), Expect = 3e-51
Identities = 122/300 (40%), Positives = 167/300 (55%), Gaps = 65/300 (21%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
+E Y K++K+GEGTY VYKG+ K T +VA+K+IRLE EEG P TAIRE+SLLK+L+H
Sbjct: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 226
Query: 61 PNIVSLQDV-------------LMQDSRLYL-------------IFEF------------ 82
NIV+L D+ L +D + YL +F F
Sbjct: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 286
Query: 83 --LSMDLK------------KYLD-------SIPPGQYMDSSLVKVVTLWYRSPEVLLGS 121
L DLK K D SIP Y + +VVTLWYR P++LLGS
Sbjct: 287 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSN----EVVTLWYRPPDILLGS 342
Query: 122 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 181
YST +D+W +G IF E+AT +PLF G + +QL IFR LGTP E WP + S +++K
Sbjct: 343 TDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFK 402
Query: 182 N-TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 240
+PK++ +L SH LD +G DLL+K+L ++ RIS + A+ HP+F L +I K+
Sbjct: 403 TYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKL 462
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 198 bits (504), Expect = 3e-51
Identities = 122/300 (40%), Positives = 167/300 (55%), Gaps = 65/300 (21%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
+E Y K++K+GEGTY VYKG+ K T +VA+K+IRLE EEG P TAIRE+SLLK+L+H
Sbjct: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 220
Query: 61 PNIVSLQDV-------------LMQDSRLYL-------------IFEF------------ 82
NIV+L D+ L +D + YL +F F
Sbjct: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 280
Query: 83 --LSMDLK------------KYLD-------SIPPGQYMDSSLVKVVTLWYRSPEVLLGS 121
L DLK K D SIP Y + +VVTLWYR P++LLGS
Sbjct: 281 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSN----EVVTLWYRPPDILLGS 336
Query: 122 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 181
YST +D+W +G IF E+AT +PLF G + +QL IFR LGTP E WP + S +++K
Sbjct: 337 TDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFK 396
Query: 182 N-TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 240
+PK++ +L SH LD +G DLL+K+L ++ RIS + A+ HP+F L +I K+
Sbjct: 397 TYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKL 456
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 196 bits (498), Expect = 2e-50
Identities = 118/300 (39%), Positives = 162/300 (54%), Gaps = 65/300 (21%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
+E Y K++K+GEGTY V+KGR K T +VA+K+IRLE EEG P TAIRE+SLLK L+H
Sbjct: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKNLKH 229
Query: 61 PNIVSLQDVLMQDSRLYL--------------------------IFEF------------ 82
NIV+L D++ D L L IF F
Sbjct: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 289
Query: 83 --LSMDLK------------KYLD-------SIPPGQYMDSSLVKVVTLWYRSPEVLLGS 121
L DLK K D S+P Y + +VVTLWYR P+VLLGS
Sbjct: 290 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSN----EVVTLWYRPPDVLLGS 345
Query: 122 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 181
YSTP+D+W +G I E+AT +PLF G + ++L IFR LGTP E WP V + +++
Sbjct: 346 TEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFR 405
Query: 182 N-TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 240
+FP + P L +H LD +G+ LLS +L+Y+ R+S + AL+H YF L ++ ++
Sbjct: 406 TYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 465
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 196 bits (498), Expect = 2e-50
Identities = 118/300 (39%), Positives = 162/300 (54%), Gaps = 65/300 (21%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
+E Y K++K+GEGTY V+KGR K T +VA+K+IRLE EEG P TAIRE+SLLK L+H
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKNLKH 199
Query: 61 PNIVSLQDVLMQDSRLYL--------------------------IFEF------------ 82
NIV+L D++ D L L IF F
Sbjct: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 259
Query: 83 --LSMDLK------------KYLD-------SIPPGQYMDSSLVKVVTLWYRSPEVLLGS 121
L DLK K D S+P Y + +VVTLWYR P+VLLGS
Sbjct: 260 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSN----EVVTLWYRPPDVLLGS 315
Query: 122 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 181
YSTP+D+W +G I E+AT +PLF G + ++L IFR LGTP E WP V + +++
Sbjct: 316 TEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFR 375
Query: 182 N-TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 240
+FP + P L +H LD +G+ LLS +L+Y+ R+S + AL+H YF L ++ ++
Sbjct: 376 TYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 435
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 196 bits (498), Expect = 2e-50
Identities = 118/300 (39%), Positives = 162/300 (54%), Gaps = 65/300 (21%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
+E Y K++K+GEGTY V+KGR K T +VA+K+IRLE EEG P TAIRE+SLLK L+H
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKNLKH 199
Query: 61 PNIVSLQDVLMQDSRLYL--------------------------IFEF------------ 82
NIV+L D++ D L L IF F
Sbjct: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 259
Query: 83 --LSMDLK------------KYLD-------SIPPGQYMDSSLVKVVTLWYRSPEVLLGS 121
L DLK K D S+P Y + +VVTLWYR P+VLLGS
Sbjct: 260 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSN----EVVTLWYRPPDVLLGS 315
Query: 122 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 181
YSTP+D+W +G I E+AT +PLF G + ++L IFR LGTP E WP V + +++
Sbjct: 316 TEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFR 375
Query: 182 N-TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 240
+FP + P L +H LD +G+ LLS +L+Y+ R+S + AL+H YF L ++ ++
Sbjct: 376 TYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 435
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 190 bits (482), Expect = 1e-48
Identities = 119/289 (41%), Positives = 158/289 (54%), Gaps = 58/289 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
M+ Y K+EKIGEGTYG V+K +++ T ++VA+K++RL+ ++EGVPS+A+REI LLKEL+H
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 61 PNIVSLQDVLMQ-----------DSRLYLIFEFLSMDL-----KKYLDSIPPG------- 97
NIV L DVL D L F+ + DL K +L + G
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120
Query: 98 --------------------QYMDSSLVK------------VVTLWYRSPEVLLGSARYS 125
+ D L + VVTLWYR P+VL G+ YS
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
Query: 126 TPVDIWSIGTIFAELATK-KPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 184
T +D+WS G IFAELA +PLF G+ DQL RIFR LGTP E WP + L DYK +
Sbjct: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK-PY 239
Query: 185 PKW-KPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 232
P + SL + V L+ G DLL +L +P +RIS + AL HPYF+D
Sbjct: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 178 bits (451), Expect = 4e-45
Identities = 110/297 (37%), Positives = 158/297 (53%), Gaps = 67/297 (22%)
Query: 2 EDYTKIEKIGEGTYGVVYKGRH-KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-- 58
+ Y + +IGEG YG V+K R K G+ VA+K++R+++ EEG+P + IRE+++L+ L
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 59 -RHPNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIP-PG-------------- 97
HPN+V L DV ++++L L+FE + DL YLD +P PG
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 98 -----------------------------QYMDSSLVKV-----------VTLWYRSPEV 117
+ D L ++ VTLWYR+PEV
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190
Query: 118 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 177
LL S+ Y+TPVD+WS+G IFAE+ +KPLF G S++DQL +I +G P E WP +L
Sbjct: 191 LLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249
Query: 178 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 234
+ F + V ++DE G DLL K L ++PAKRIS AL+HPYF DL+
Sbjct: 250 P--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304
>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 178 bits (451), Expect = 4e-45
Identities = 110/297 (37%), Positives = 158/297 (53%), Gaps = 67/297 (22%)
Query: 2 EDYTKIEKIGEGTYGVVYKGRH-KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-- 58
+ Y + +IGEG YG V+K R K G+ VA+K++R+++ EEG+P + IRE+++L+ L
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 59 -RHPNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIP-PG-------------- 97
HPN+V L DV ++++L L+FE + DL YLD +P PG
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 98 -----------------------------QYMDSSLVKV-----------VTLWYRSPEV 117
+ D L ++ VTLWYR+PEV
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190
Query: 118 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 177
LL S+ Y+TPVD+WS+G IFAE+ +KPLF G S++DQL +I +G P E WP +L
Sbjct: 191 LLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249
Query: 178 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 234
+ F + V ++DE G DLL K L ++PAKRIS AL+HPYF DL+
Sbjct: 250 P--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 161 bits (407), Expect = 5e-40
Identities = 102/288 (35%), Positives = 145/288 (50%), Gaps = 61/288 (21%)
Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE---GVPSTAIREISLLKELRH 60
Y K++ +GEG + VYK R K T Q+VA+KKI+L E G+ TA+REI LL+EL H
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLK--------------------------KYL--- 91
PNI+ L D S + L+F+F+ DL+ +YL
Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131
Query: 92 -----DSIPPGQYMDSSLV---------------------KVVTLWYRSPEVLLGSARYS 125
D P +D + V +VVT WYR+PE+L G+ Y
Sbjct: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191
Query: 126 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 185
VD+W++G I AEL + P GDS++DQL RIF LGTP E WP++ SL DY TF
Sbjct: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV-TFK 250
Query: 186 KWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 232
+ PG H+ ++ LDL+ + +++P RI+ AL YF++
Sbjct: 251 SF-PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 160 bits (406), Expect = 7e-40
Identities = 93/290 (32%), Positives = 149/290 (51%), Gaps = 58/290 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
++++ K+ +IGEGTYG+VY+ R T ++VA+KK+R++ E++G+P +++REI+LL LRH
Sbjct: 36 VKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRH 95
Query: 61 PNIVSLQDVLMQD--SRLYLIFEFLSMDLKKYLDSIPPG-----------------QYMD 101
PNIV L++V++ + ++L+ + DL L+++P QY+
Sbjct: 96 PNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLH 155
Query: 102 SSLV--------------------------------------KVVTLWYRSPEVLLGSAR 123
+ + KVVTLWYR+PE+LLG+
Sbjct: 156 RNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTT 215
Query: 124 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 183
+T +D+W++G I AEL +PL G SEI Q+ I + LGTP+ +WP L
Sbjct: 216 QTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQY 275
Query: 184 FPKWKP-GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 232
+ +P +L L E GL LL + +YDP KR + L YF +
Sbjct: 276 SLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKE 325
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 157 bits (396), Expect = 1e-38
Identities = 97/288 (33%), Positives = 141/288 (48%), Gaps = 58/288 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR- 59
M+ Y + +IGEG +G+V+K +H TG++VA+KK+ L E+G P+ A+REI L+E+
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDL----------------KKYLDSIPPG------ 97
+ +V L+ V L FEF+ DL K YL + G
Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120
Query: 98 ---------------------QYMDSSLVKV-------------VTLWYRSPEVLLGSAR 123
+ D L +V T WYR+PE+L G+ +
Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ 180
Query: 124 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY-KN 182
Y VD+WS+G I EL PLF G ++I+QL + R LGTPN +VWPE+ L DY K
Sbjct: 181 YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 240
Query: 183 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 230
+F + P L + ++ LDLL + L+Y P +RI+ AL H YF
Sbjct: 241 SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 288
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 153 bits (386), Expect = 1e-37
Identities = 97/297 (32%), Positives = 146/297 (49%), Gaps = 70/297 (23%)
Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63
Y K+ KIG+GT+G V+K RH+ TGQ VA+KK+ +E+E+EG P TA+REI +L+ L+H N+
Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78
Query: 64 VSLQDVLMQDSR--------LYLIFE----------------FLSMDLKKYLDSIPPGQY 99
V+L ++ + +YL+F+ F ++K+ + + G Y
Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138
Query: 100 M---------------------------DSSLVK----------------VVTLWYRSPE 116
D L + VVTLWYR PE
Sbjct: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198
Query: 117 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 176
+LLG Y P+D+W G I AE+ T+ P+ G++E QL I + G+ EVWP V++
Sbjct: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258
Query: 177 LQDY-KNTFPKWKPGSLASHVKNL--DENGLDLLSKMLIYDPAKRISGKMALNHPYF 230
+ Y K K + + +K D LDL+ K+L+ DPA+RI ALNH +F
Sbjct: 259 YELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 149 bits (377), Expect = 2e-36
Identities = 110/302 (36%), Positives = 143/302 (47%), Gaps = 82/302 (27%)
Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-- 59
+ Y K+EK+GEG+Y VYKG+ K G++VA+K IRL+ EEEG P TAIRE SLLK L+
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
Query: 60 ----------------------HPNIVSLQDV----LMQDSRLYLIFEFLS--------- 84
H ++ D L D+ +F+ L
Sbjct: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRY 233
Query: 85 ---MDLK------------KYLD-------SIPPGQYMDSSLVKVVTLWYRSPEVLLGSA 122
DLK K D S+P Y + +VVTLWYR P+VLLGS
Sbjct: 234 ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSN----EVVTLWYRPPDVLLGST 289
Query: 123 RYSTPVDIWSIGTIFAELATKKPLFHGDSEI-DQLFRIFRALGTPNNEVWPEVESLQDY- 180
YST +D+W +G IF E+ F G +I DQL RIF LGTPN + WP V SL +
Sbjct: 290 EYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFK 349
Query: 181 ---------KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 231
KN W S +H + DL SK+L P R+S + AL+H YF+
Sbjct: 350 PERFTLYSSKNLRQAWNKLSYVNHAE-------DLASKLLQCSPKNRLSAQAALSHEYFS 402
Query: 232 DL 233
DL
Sbjct: 403 DL 404
>gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
Length = 303
Score = 144 bits (364), Expect = 5e-35
Identities = 102/294 (34%), Positives = 139/294 (47%), Gaps = 69/294 (23%)
Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG---VPSTAIREISLLKELR- 59
Y + +IG G YG VYK R +G VA+K +R+ + G +P + +RE++LL+ L
Sbjct: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
Query: 60 --HPNIVSLQDVLM------------------QDSRLYLI-------------------- 79
HPN+V L DV QD R YL
Sbjct: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125
Query: 80 --FEFLSMDLKKYLDSIPPG--------------------QYMDSSLVKVVTLWYRSPEV 117
+FL + + D P Y + VVTLWYR+PEV
Sbjct: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185
Query: 118 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 177
LL S Y+TPVD+WS+G IFAE+ +KPLF G+SE DQL +IF +G P + WP SL
Sbjct: 186 LLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244
Query: 178 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 231
+ FP P + S V ++E+G LL +ML ++P KRIS AL H Y +
Sbjct: 245 P--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296
>gi|11496279 male germ cell-associated kinase [Homo sapiens]
Length = 623
Score = 142 bits (358), Expect = 3e-34
Identities = 94/287 (32%), Positives = 146/287 (50%), Gaps = 60/287 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAIREISLLKEL 58
M YT + ++G+GTYG V G+ +G++VA+K+++ + S +E + +RE+ LK+L
Sbjct: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMN---LREVKSLKKL 57
Query: 59 RHPNIVSLQDV--------------------LMQDSR-----------LYLIFEFLSMDL 87
H N++ L++V LM+D +Y I + L+
Sbjct: 58 NHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
Query: 88 KK---YLDSIPPGQY-MDSSLVKVV-------------------TLWYRSPEVLLGSARY 124
K + D P M LVK+ T WYR+PEVLL S+ Y
Sbjct: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVY 177
Query: 125 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN-T 183
S+P+D+W++G+I AEL +PLF G SE+D++F+I + LGTP WPE L N
Sbjct: 178 SSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFR 237
Query: 184 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 230
FP+ P +L + + N + L+++ML +DP KR + AL HPYF
Sbjct: 238 FPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF 284
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 141 bits (355), Expect = 6e-34
Identities = 95/287 (33%), Positives = 141/287 (49%), Gaps = 60/287 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAIREISLLKEL 58
M YT I ++G+GTYG V GR +G+++A+KK++ + S EE + +RE+ LK+L
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMN---LREVKSLKKL 57
Query: 59 RHPNIVSLQDVLMQDSR-------------------------------LYLIFEFLSMDL 87
H N+V L++V+ ++ +Y I + L+
Sbjct: 58 NHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIH 117
Query: 88 KK---YLDSIPPGQY-MDSSLVKVV-------------------TLWYRSPEVLLGSARY 124
K + D P M LVK+ T WYR+PEVLL S Y
Sbjct: 118 KHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNY 177
Query: 125 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN-T 183
S+P+D+W++G I AE+ T +PLF G SEID +F+I + LGTP WPE L N
Sbjct: 178 SSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFR 237
Query: 184 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 230
+P+ P +L + + N + LL ML +DP KR + AL +PYF
Sbjct: 238 WPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF 284
>gi|7662388 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 141 bits (355), Expect = 6e-34
Identities = 95/287 (33%), Positives = 141/287 (49%), Gaps = 60/287 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAIREISLLKEL 58
M YT I ++G+GTYG V GR +G+++A+KK++ + S EE + +RE+ LK+L
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMN---LREVKSLKKL 57
Query: 59 RHPNIVSLQDVLMQDSR-------------------------------LYLIFEFLSMDL 87
H N+V L++V+ ++ +Y I + L+
Sbjct: 58 NHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIH 117
Query: 88 KK---YLDSIPPGQY-MDSSLVKVV-------------------TLWYRSPEVLLGSARY 124
K + D P M LVK+ T WYR+PEVLL S Y
Sbjct: 118 KHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNY 177
Query: 125 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN-T 183
S+P+D+W++G I AE+ T +PLF G SEID +F+I + LGTP WPE L N
Sbjct: 178 SSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFR 237
Query: 184 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 230
+P+ P +L + + N + LL ML +DP KR + AL +PYF
Sbjct: 238 WPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF 284
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 134 bits (337), Expect = 7e-32
Identities = 91/288 (31%), Positives = 128/288 (44%), Gaps = 58/288 (20%)
Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63
Y ++ +G G YG V TG VA+KK+ + E A RE+ LLK +RH N+
Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86
Query: 64 VSLQDVLMQDSRL------YLIFEFLSMDLKKYLD------------------------- 92
+ L DV D L YL+ F+ DL K +
Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146
Query: 93 ------SIPPG----------QYMDSSLVK---------VVTLWYRSPEVLLGSARYSTP 127
+ PG + +D L + VVT WYR+PEV+L RY+
Sbjct: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQT 206
Query: 128 VDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES--LQDYKNTFP 185
VDIWS+G I AE+ T K LF G +DQL I + GTP E ++S ++Y P
Sbjct: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266
Query: 186 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 233
+ + AS + N ++LL KML+ D +R++ AL HPYF L
Sbjct: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 133 bits (335), Expect = 1e-31
Identities = 94/291 (32%), Positives = 142/291 (48%), Gaps = 59/291 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK--KIRLESEEEGVPS------------ 46
+E++ + +I EGTYGVVY+ + K T ++VA+K K+ E E + S
Sbjct: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
Query: 47 ---TAIREI---------------------SLLKELRHP----NIVSLQDVLMQDSRLYL 78
+REI SL++ ++ P + +L L++ +
Sbjct: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 530
Query: 79 IFEFLSMDLK------KYLDSIPPGQY---------MDSSLVKVVTLWYRSPEVLLGSAR 123
L DLK + + G + + + VVTLWYR+PE+LLG+
Sbjct: 531 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 590
Query: 124 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 182
YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP L K
Sbjct: 591 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 650
Query: 183 TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 232
TF + +L L + G DL++K L Y P +RIS + L H YF +
Sbjct: 651 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 701
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 133 bits (335), Expect = 1e-31
Identities = 94/291 (32%), Positives = 142/291 (48%), Gaps = 59/291 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK--KIRLESEEEGVPS------------ 46
+E++ + +I EGTYGVVY+ + K T ++VA+K K+ E E + S
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479
Query: 47 ---TAIREI---------------------SLLKELRHP----NIVSLQDVLMQDSRLYL 78
+REI SL++ ++ P + +L L++ +
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539
Query: 79 IFEFLSMDLK------KYLDSIPPGQY---------MDSSLVKVVTLWYRSPEVLLGSAR 123
L DLK + + G + + + VVTLWYR+PE+LLG+
Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 599
Query: 124 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 182
YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP L K
Sbjct: 600 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 659
Query: 183 TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 232
TF + +L L + G DL++K L Y P +RIS + L H YF +
Sbjct: 660 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 710
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 133 bits (335), Expect = 1e-31
Identities = 94/291 (32%), Positives = 142/291 (48%), Gaps = 59/291 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK--KIRLESEEEGVPS------------ 46
+E++ + +I EGTYGVVY+ + K T ++VA+K K+ E E + S
Sbjct: 388 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 447
Query: 47 ---TAIREI---------------------SLLKELRHP----NIVSLQDVLMQDSRLYL 78
+REI SL++ ++ P + +L L++ +
Sbjct: 448 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 507
Query: 79 IFEFLSMDLK------KYLDSIPPGQY---------MDSSLVKVVTLWYRSPEVLLGSAR 123
L DLK + + G + + + VVTLWYR+PE+LLG+
Sbjct: 508 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 567
Query: 124 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 182
YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP L K
Sbjct: 568 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 627
Query: 183 TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 232
TF + +L L + G DL++K L Y P +RIS + L H YF +
Sbjct: 628 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 678
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 133 bits (335), Expect = 1e-31
Identities = 94/291 (32%), Positives = 142/291 (48%), Gaps = 59/291 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK--KIRLESEEEGVPS------------ 46
+E++ + +I EGTYGVVY+ + K T ++VA+K K+ E E + S
Sbjct: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
Query: 47 ---TAIREI---------------------SLLKELRHP----NIVSLQDVLMQDSRLYL 78
+REI SL++ ++ P + +L L++ +
Sbjct: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 496
Query: 79 IFEFLSMDLK------KYLDSIPPGQY---------MDSSLVKVVTLWYRSPEVLLGSAR 123
L DLK + + G + + + VVTLWYR+PE+LLG+
Sbjct: 497 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 556
Query: 124 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 182
YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP L K
Sbjct: 557 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 616
Query: 183 TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 232
TF + +L L + G DL++K L Y P +RIS + L H YF +
Sbjct: 617 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 667
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 133 bits (335), Expect = 1e-31
Identities = 94/291 (32%), Positives = 142/291 (48%), Gaps = 59/291 (20%)
Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK--KIRLESEEEGVPS------------ 46
+E++ + +I EGTYGVVY+ + K T ++VA+K K+ E E + S
Sbjct: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225
Query: 47 ---TAIREI---------------------SLLKELRHP----NIVSLQDVLMQDSRLYL 78
+REI SL++ ++ P + +L L++ +
Sbjct: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 285
Query: 79 IFEFLSMDLK------KYLDSIPPGQY---------MDSSLVKVVTLWYRSPEVLLGSAR 123
L DLK + + G + + + VVTLWYR+PE+LLG+
Sbjct: 286 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 345
Query: 124 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 182
YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP L K
Sbjct: 346 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 405
Query: 183 TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 232
TF + +L L + G DL++K L Y P +RIS + L H YF +
Sbjct: 406 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 456
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,007,365
Number of Sequences: 37866
Number of extensions: 375313
Number of successful extensions: 2567
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 492
Number of HSP's successfully gapped in prelim test: 191
Number of HSP's that attempted gapping in prelim test: 1046
Number of HSP's gapped (non-prelim): 1221
length of query: 240
length of database: 18,247,518
effective HSP length: 99
effective length of query: 141
effective length of database: 14,498,784
effective search space: 2044328544
effective search space used: 2044328544
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.