Search of human proteins with 160948610

Search of human proteins with 160948610

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|160948610 E3 ubiquitin-protein ligase UBR3 [Homo sapiens]
         (1888 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|160948610 E3 ubiquitin-protein ligase UBR3 [Homo sapiens]         3841   0.0  
gi|27597061 ubiquitin protein ligase E3 component n-recognin 2 [...   153   2e-36
gi|28372497 ubiquitin protein ligase E3 component n-recognin 1 [...   129   3e-29
gi|55749544 SH3 multiple domains 1 [Homo sapiens]                      43   0.003
gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3 c...    42   0.004
gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3 c...    42   0.004
gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [...    42   0.006
gi|64276486 serologically defined colon cancer antigen 10 [Homo ...    40   0.016
gi|28875784 armadillo repeat containing 5 isoform b [Homo sapiens]     40   0.016
gi|157426856 armadillo repeat containing 5 isoform a [Homo sapiens]    40   0.016
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    39   0.037
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    39   0.037
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    39   0.037
gi|239787919 low density lipoprotein receptor-related protein 11...    37   0.14 
gi|122937319 even-skipped homeobox 2 [Homo sapiens]                    37   0.24 
gi|4504713 insulinoma-associated 1 [Homo sapiens]                      37   0.24 
gi|33457336 chromosome 14 open reading frame 4 [Homo sapiens]          37   0.24 
gi|55749531 splicing factor 3B subunit 2 [Homo sapiens]                36   0.31 
gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens]              36   0.41 
gi|24497554 homeobox A13 [Homo sapiens]                                35   0.53 
gi|27262632 neural stem cell-derived dendrite regulator [Homo sa...    35   0.53 
gi|153791670 keratin 76 [Homo sapiens]                                 35   0.69 
gi|40288197 GATA binding protein 6 [Homo sapiens]                      35   0.69 
gi|4758392 forkhead box D1 [Homo sapiens]                              35   0.69 
gi|239757043 PREDICTED: functional smad suppressing element 18 [...    35   0.91 
gi|239751555 PREDICTED: functional smad suppressing element 18 [...    35   0.91 
gi|239746067 PREDICTED: functional smad suppressing element 18 [...    35   0.91 
gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens]             34   1.2  
gi|91208420 bassoon protein [Homo sapiens]                             34   1.5  
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s...    33   2.0  

>gi|160948610 E3 ubiquitin-protein ligase UBR3 [Homo sapiens]
          Length = 1888

 Score = 3841 bits (9962), Expect = 0.0
 Identities = 1888/1888 (100%), Positives = 1888/1888 (100%)

Query: 1    MAAAAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLS 60
            MAAAAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLS
Sbjct: 1    MAAAAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLS 60

Query: 61   AERPLAAAAGGEDAAAAGGGGGPGAAEEEALEWCKCLLAGGGGYDEFCAAVRAYDPAALC 120
            AERPLAAAAGGEDAAAAGGGGGPGAAEEEALEWCKCLLAGGGGYDEFCAAVRAYDPAALC
Sbjct: 61   AERPLAAAAGGEDAAAAGGGGGPGAAEEEALEWCKCLLAGGGGYDEFCAAVRAYDPAALC 120

Query: 121  GLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMRE 180
            GLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMRE
Sbjct: 121  GLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMRE 180

Query: 181  SGFCKRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYLREGYNEPAADGPSEKDLNK 240
            SGFCKRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYLREGYNEPAADGPSEKDLNK
Sbjct: 181  SGFCKRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYLREGYNEPAADGPSEKDLNK 240

Query: 241  VLQLLEPQISFLEDLTKMGGAMRSVLTQVLTNQQNYKDLTSGLGENACVKKSHEKYLIAL 300
            VLQLLEPQISFLEDLTKMGGAMRSVLTQVLTNQQNYKDLTSGLGENACVKKSHEKYLIAL
Sbjct: 241  VLQLLEPQISFLEDLTKMGGAMRSVLTQVLTNQQNYKDLTSGLGENACVKKSHEKYLIAL 300

Query: 301  KSSGLTYPEDKLVYGVQEPSAGTSSLAVQGFIGATGTLGQVDSSDEDDQDGSQGLGKRKR 360
            KSSGLTYPEDKLVYGVQEPSAGTSSLAVQGFIGATGTLGQVDSSDEDDQDGSQGLGKRKR
Sbjct: 301  KSSGLTYPEDKLVYGVQEPSAGTSSLAVQGFIGATGTLGQVDSSDEDDQDGSQGLGKRKR 360

Query: 361  VKLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFPQKMVTFLLNMLPDQEYKVAFTKTFV 420
            VKLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFPQKMVTFLLNMLPDQEYKVAFTKTFV
Sbjct: 361  VKLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFPQKMVTFLLNMLPDQEYKVAFTKTFV 420

Query: 421  QHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMES 480
            QHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMES
Sbjct: 421  QHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMES 480

Query: 481  CLIKSELQDEENSLHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHGLLVTW 540
            CLIKSELQDEENSLHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHGLLVTW
Sbjct: 481  CLIKSELQDEENSLHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHGLLVTW 540

Query: 541  MNFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLSHCKVRETQEYTR 600
            MNFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLSHCKVRETQEYTR
Sbjct: 541  MNFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLSHCKVRETQEYTR 600

Query: 601  NVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPLHRYYAMFLSKAVKCQELDLDSVLPDQ 660
            NVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPLHRYYAMFLSKAVKCQELDLDSVLPDQ
Sbjct: 601  NVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPLHRYYAMFLSKAVKCQELDLDSVLPDQ 660

Query: 661  EMLMKLMIHPLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCA 720
            EMLMKLMIHPLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCA
Sbjct: 661  EMLMKLMIHPLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCA 720

Query: 721  SRLDPDYFISSVFERFKVVDLLTMASQHQNTVLDAEHERSMLEGALTFLVILLSLRLHLG 780
            SRLDPDYFISSVFERFKVVDLLTMASQHQNTVLDAEHERSMLEGALTFLVILLSLRLHLG
Sbjct: 721  SRLDPDYFISSVFERFKVVDLLTMASQHQNTVLDAEHERSMLEGALTFLVILLSLRLHLG 780

Query: 781  MSDDEILRAEMVAQLCMNDRTHSSLLDLIPENPNPKSGIIPGSYSFESVLSAVADFKAPV 840
            MSDDEILRAEMVAQLCMNDRTHSSLLDLIPENPNPKSGIIPGSYSFESVLSAVADFKAPV
Sbjct: 781  MSDDEILRAEMVAQLCMNDRTHSSLLDLIPENPNPKSGIIPGSYSFESVLSAVADFKAPV 840

Query: 841  FEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSAMDRYTAFLKQSGKFPGNPW 900
            FEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSAMDRYTAFLKQSGKFPGNPW
Sbjct: 841  FEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSAMDRYTAFLKQSGKFPGNPW 900

Query: 901  PPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQNLSEHVLCMVLYLIELGLE 960
            PPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQNLSEHVLCMVLYLIELGLE
Sbjct: 901  PPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQNLSEHVLCMVLYLIELGLE 960

Query: 961  NSAEEESDEEASVGGPERCHDSWFPGSNLVSNMRHFINYVRVRVPETAPEVKRDSPASTS 1020
            NSAEEESDEEASVGGPERCHDSWFPGSNLVSNMRHFINYVRVRVPETAPEVKRDSPASTS
Sbjct: 961  NSAEEESDEEASVGGPERCHDSWFPGSNLVSNMRHFINYVRVRVPETAPEVKRDSPASTS 1020

Query: 1021 SDNLGSLQNSGTAQVFSLVAERRKKFQEIINRSSSEANQVVRPKTSSKWSAPGSAPQLTT 1080
            SDNLGSLQNSGTAQVFSLVAERRKKFQEIINRSSSEANQVVRPKTSSKWSAPGSAPQLTT
Sbjct: 1021 SDNLGSLQNSGTAQVFSLVAERRKKFQEIINRSSSEANQVVRPKTSSKWSAPGSAPQLTT 1080

Query: 1081 AILEIKESILSLLIKLHHKLSGKQNSYYPPWLDDIEILIQPEIPKYSHGDGITAVERILL 1140
            AILEIKESILSLLIKLHHKLSGKQNSYYPPWLDDIEILIQPEIPKYSHGDGITAVERILL
Sbjct: 1081 AILEIKESILSLLIKLHHKLSGKQNSYYPPWLDDIEILIQPEIPKYSHGDGITAVERILL 1140

Query: 1141 KAASQSRMNKRIIEEICRKVTPPVPPKKVTAAEKKTLDKEERRQKARERQQKLLAEFASR 1200
            KAASQSRMNKRIIEEICRKVTPPVPPKKVTAAEKKTLDKEERRQKARERQQKLLAEFASR
Sbjct: 1141 KAASQSRMNKRIIEEICRKVTPPVPPKKVTAAEKKTLDKEERRQKARERQQKLLAEFASR 1200

Query: 1201 QKSFMETAMDVDSPENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVVLLQAS 1260
            QKSFMETAMDVDSPENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVVLLQAS
Sbjct: 1201 QKSFMETAMDVDSPENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVVLLQAS 1260

Query: 1261 SVLGQCRDNVEPKKLPISEEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGWEGG 1320
            SVLGQCRDNVEPKKLPISEEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGWEGG
Sbjct: 1261 SVLGQCRDNVEPKKLPISEEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGWEGG 1320

Query: 1321 VYVQTCGHTLHIDCHKSYMESLRNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSNVE 1380
            VYVQTCGHTLHIDCHKSYMESLRNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSNVE
Sbjct: 1321 VYVQTCGHTLHIDCHKSYMESLRNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSNVE 1380

Query: 1381 NNPWQRPSNKSIQDLIKEVEELQGRPGAFPSETNLSKEMESVMKDIKNTTQKKYRDYSKT 1440
            NNPWQRPSNKSIQDLIKEVEELQGRPGAFPSETNLSKEMESVMKDIKNTTQKKYRDYSKT
Sbjct: 1381 NNPWQRPSNKSIQDLIKEVEELQGRPGAFPSETNLSKEMESVMKDIKNTTQKKYRDYSKT 1440

Query: 1441 PGSPDNDFLFMYSVARTNLELELIHRGGNLCSGGASTAGKRSCLNQLFHVLALHMRLYSI 1500
            PGSPDNDFLFMYSVARTNLELELIHRGGNLCSGGASTAGKRSCLNQLFHVLALHMRLYSI
Sbjct: 1441 PGSPDNDFLFMYSVARTNLELELIHRGGNLCSGGASTAGKRSCLNQLFHVLALHMRLYSI 1500

Query: 1501 DSEYNPWRKLTQLEEMNPQLGYEEQQPEVPILYHDVTSLLLIQILMMPQPLRKDHFTCIV 1560
            DSEYNPWRKLTQLEEMNPQLGYEEQQPEVPILYHDVTSLLLIQILMMPQPLRKDHFTCIV
Sbjct: 1501 DSEYNPWRKLTQLEEMNPQLGYEEQQPEVPILYHDVTSLLLIQILMMPQPLRKDHFTCIV 1560

Query: 1561 KVLFTLLYTQALAALSVKCSEEDRSAWKHAGALKKSTCDAEKSYEVLLSFVISELFKGKL 1620
            KVLFTLLYTQALAALSVKCSEEDRSAWKHAGALKKSTCDAEKSYEVLLSFVISELFKGKL
Sbjct: 1561 KVLFTLLYTQALAALSVKCSEEDRSAWKHAGALKKSTCDAEKSYEVLLSFVISELFKGKL 1620

Query: 1621 YHEEGTQECAMVNPIAWSPESMEKCLQDFCLPFLRITSLLQHHLFGEDLPSCQEEEEFSV 1680
            YHEEGTQECAMVNPIAWSPESMEKCLQDFCLPFLRITSLLQHHLFGEDLPSCQEEEEFSV
Sbjct: 1621 YHEEGTQECAMVNPIAWSPESMEKCLQDFCLPFLRITSLLQHHLFGEDLPSCQEEEEFSV 1680

Query: 1681 LASCLGLLPTFYQTEHPFISASCLDWPVPAFDIITQWCFEIKSFTERHAEQGKALLIQES 1740
            LASCLGLLPTFYQTEHPFISASCLDWPVPAFDIITQWCFEIKSFTERHAEQGKALLIQES
Sbjct: 1681 LASCLGLLPTFYQTEHPFISASCLDWPVPAFDIITQWCFEIKSFTERHAEQGKALLIQES 1740

Query: 1741 KWKLPHLLQLPENYNTIFQYYHRKTCSVCTKVPKDPAVCLVCGTFVCLKGLCCKQQSYCE 1800
            KWKLPHLLQLPENYNTIFQYYHRKTCSVCTKVPKDPAVCLVCGTFVCLKGLCCKQQSYCE
Sbjct: 1741 KWKLPHLLQLPENYNTIFQYYHRKTCSVCTKVPKDPAVCLVCGTFVCLKGLCCKQQSYCE 1800

Query: 1801 CVLHSQNCGAGTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICKE 1860
            CVLHSQNCGAGTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICKE
Sbjct: 1801 CVLHSQNCGAGTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICKE 1860

Query: 1861 RYKVLEQQWISHTFDHINKRWGPHYNGL 1888
            RYKVLEQQWISHTFDHINKRWGPHYNGL
Sbjct: 1861 RYKVLEQQWISHTFDHINKRWGPHYNGL 1888


>gi|27597061 ubiquitin protein ligase E3 component n-recognin 2 [Homo
            sapiens]
          Length = 1755

 Score =  153 bits (386), Expect = 2e-36
 Identities = 193/800 (24%), Positives = 322/800 (40%), Gaps = 162/800 (20%)

Query: 1161 TPPVPPKKVTAAEKKTLDKE--ERRQKA---RERQQKLLAEFASRQKSFMET-------A 1208
            T PV   + T  E+ + DK+  ER++KA   R R++K++A+ +  Q+ F++         
Sbjct: 1008 TSPVAETEGTIMEESSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQT 1067

Query: 1209 MDVDSPENDI--------PMEITT---AEPQVSEA--VYDCVICGQSGPSS-EDRPTGLV 1254
            +++D+  + +         M +T    A+ QV E      C++C +      E R   L 
Sbjct: 1068 LELDASTSAVLDHSPVASDMTLTALGPAQTQVPEQRQFVTCILCQEEQEVKVESRAMVLA 1127

Query: 1255 VLLQASSVLGQCRDNVEPKKLPISEEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVS 1314
              +Q S+VL + R         I + E+  P      +H            D SC     
Sbjct: 1128 AFVQRSTVLSKNRSKF------IQDPEKYDP----LFMHP-----------DLSC----- 1161

Query: 1315 IGWEGGVYVQTCGHTLHIDCHKSYMESL-----RNDQVLQ---GFSVDKGEFTCPLCRQF 1366
                 G +  +CGH +H  C + Y +S+     R  Q L+    + V+ GEF CPLC   
Sbjct: 1162 -----GTHTSSCGHIMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVENGEFLCPLCECL 1216

Query: 1367 ANSVLPCY-PGSNVENN-----------PWQRPSN---KSIQDLIKE------------- 1398
            +N+V+P   P  N+ NN            W R  +   K++Q L KE             
Sbjct: 1217 SNTVIPLLLPPRNIFNNRLNFSDQPNLTQWIRTISQQIKALQFLRKEESTPNNASTKNSE 1276

Query: 1399 -VEELQGRPGAFPS---ETNLSKEMESVMKDIKNTTQKKYRDYSKTPGSPDNDFLFMYSV 1454
             V+ELQ   G  P    +   S+ ++ ++      T K           P    +   S 
Sbjct: 1277 NVDELQLPEGFRPDFRPKIPYSESIKEMLTTFGTATYKVGLKVHPNEEDPRVPIMCWGSC 1336

Query: 1455 ARTNLELELIHRGGNLCSGGASTAGKRSCLNQLFHVLALHMRLYSIDSEYNPWRKLTQLE 1514
            A T   +E I    +    G        CL  L    A H  + S+      + KL    
Sbjct: 1337 AYTIQSIERILSDEDKPLFGPLPCRLDDCLRSLTRFAAAHWTVASVSVVQGHFCKL--FA 1394

Query: 1515 EMNPQLGYEEQQPEVP-ILYHDVTSLLLIQILMMPQPLRKDHFTCI------VKVLFTLL 1567
             + P   +EE    +P IL  D+  LL+  +L  P  L+   F+ I      + +   + 
Sbjct: 1395 SLVPNDSHEE----LPCILDIDMFHLLVGLVLAFPA-LQCQDFSGISLGTGDLHIFHLVT 1449

Query: 1568 YTQALAALSVKCSEEDRSAWKHAGALKKSTCDAEKSYEVLLSFVISELFKGKLYHEEGTQ 1627
                +  L   C+EE+         + +     E+   VL  +     + G    E    
Sbjct: 1450 MAHIIQILLTSCTEEN--------GMDQENPPCEEESAVLALYKTLHQYTGSALKEI--- 1498

Query: 1628 ECAMVNPIAWSPESMEKCLQDFCLPFLRITSLLQHHLFGEDLP---SCQEEEEFSVLASC 1684
                  P  W    + + ++   +PFL+ ++L  H+L G   P          F  L S 
Sbjct: 1499 ------PSGWH---LWRSVRAGIMPFLKCSALFFHYLNGVPSPPDIQVPGTSHFEHLCSY 1549

Query: 1685 LGL---LPTFYQTEHPFISASCLDWPVPAFDIITQWC--FEIKSFTERHAEQGKALLIQE 1739
            L L   L   +Q     +++           +I  WC   E+K + E   E+      +E
Sbjct: 1550 LSLPNNLICLFQENSEIMNS-----------LIESWCRNSEVKRYLE--GERDAIRYPRE 1596

Query: 1740 SKWKLPHLLQLPENYNTIFQYYHRKTCSVCT-KVPKDPAVCLVCGTFVCLKGLCCKQQSY 1798
            S      L+ LPE+Y+++       +C        + P +CLVCG+ +C +  CC+ +  
Sbjct: 1597 SN----KLINLPEDYSSLINQASNFSCPKSGGDKSRAPTLCLVCGSLLCSQSYCCQTELE 1652

Query: 1799 CE----CVLHSQNCGAGTGIFLLINASVIIIIRGH-RFCLWGSVYLDAHGEEDRDLRRGK 1853
             E    C  H+ +CG+G GIFL +    ++ + G  + C +   YLD +GE D+ LRRG 
Sbjct: 1653 GEDVGACTAHTYSCGSGVGIFLRVRECQVLFLAGKTKGCFYSPPYLDDYGETDQGLRRGN 1712

Query: 1854 PLYICKERYKVLEQQWISHT 1873
            PL++CKER+K +++ W  H+
Sbjct: 1713 PLHLCKERFKKIQKLWHQHS 1732



 Score =  124 bits (312), Expect = 7e-28
 Identities = 134/607 (22%), Positives = 255/607 (42%), Gaps = 86/607 (14%)

Query: 401 FLLNMLPDQEYKVAFTKTFVQHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQV 460
           F+ ++L D +YK  F   F ++Y  + +   +      +S  +  +SVQ F+   LAR +
Sbjct: 374 FMSSLLMDLKYKKLFAVRFAKNYQQLQRDFMEDDHERAVS--VTALSVQFFTAPTLARML 431

Query: 461 TEECQLLDIMVTVLLYMMESCLIKSELQDEENSL----------HVVVNCGEALLKNNTY 510
             E  L+ I++   +  +     +   Q E  +            ++++    L+   T 
Sbjct: 432 ITEENLMSIIIKTFMDHLRHRDAQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKPTE 491

Query: 511 WPLVSDFINILSHQSVAKRFLEDHGLLVTWMNFVSFFQGMNLNKRELNEHVEFESQTYYA 570
           W              + ++FLE       ++  +   QGM+   R++ +H+E E + + A
Sbjct: 492 WS-----------DELRQKFLEGFD---AFLELLKCMQGMDPITRQVGQHIEMEPE-WEA 536

Query: 571 AFAAELEACAQPMWGLLSHCKVRETQEYTRNVVRYCLEALQDWFDAINFVDEP------- 623
           AF  +++     +  +   C   E  +      + CL  L          ++P       
Sbjct: 537 AFTLQMKL-THVISMMQDWCASDE--KVLIEAYKKCLAVLMQCHGGYTDGEQPITLSICG 593

Query: 624 ----------APNQVTFHLPLHRYYA---MFLSKAVKCQELDLDSVLPDQEMLMKLMI-H 669
                     +  +V+ HLP+ R  A   + LSK+    +     +LP  E+   ++I H
Sbjct: 594 HSVETIRYCVSQEKVSIHLPVSRLLAGLHVLLSKSEVAYKFP--ELLPLSELSPPMLIEH 651

Query: 670 PLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFI 729
           PL+     A++H+ MW RNG  +  Q   Y        M D D+ +LQ   S +DP++F+
Sbjct: 652 PLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDVVMLQTGVSMMDPNHFL 711

Query: 730 SSVFERFKVVDLLTMASQHQNTVLDAEHE------RSMLEGALTFLVILLSLRLHLGM-- 781
             +  RF++  + +     +    +  H+       +++E  L  +++L+  R   G+  
Sbjct: 712 MIMLSRFELYQIFSTPDYGKRFSSEITHKDVVQQNNTLIEEMLYLIIMLVGERFSPGVGQ 771

Query: 782 --SDDEILRAEMVAQLCMNDRTHSSLLDLIPENPNPKSGIIPGSYSFESVLSAVADFKAP 839
             + DEI R E++ QL +    HS L+  +PE+ N ++G+       ESV+ AVA FK P
Sbjct: 772 VNATDEIKR-EIIHQLSIKPMAHSELVKSLPEDENKETGM-------ESVIEAVAHFKKP 823

Query: 840 VFEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSAMDRYTAFLKQSGKFPGNP 899
                G   +GMY  K E   +EF+          +   + A  +     ++    P   
Sbjct: 824 -----GLTGRGMYELKPEC-AKEFNLYFYHFSRAEQSKAEEAQRKLKRQNREDTALPPPV 877

Query: 900 WPPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQNL--SEHVLCMVLYLIEL 957
            PP+       P +  L+ +L    +  ++ T+L +  ++H     SE +L  VL+LI +
Sbjct: 878 LPPF------CPLFASLVNILQSDVMLCIMGTIL-QWAVEHNGYAWSESMLQRVLHLIGM 930

Query: 958 GLENSAE 964
            L+   +
Sbjct: 931 ALQEEKQ 937



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 41/122 (33%), Positives = 61/122 (50%), Gaps = 4/122 (3%)

Query: 91  LEWCKCLLAGGGGYDEFCAAVRAYDPAALCGLVWTANFVAYRCRTCGISPCMSLCAECFH 150
           +EW  C      G+ +     +A  P+ LCG V+      Y CR C + P   LC ECF 
Sbjct: 73  MEWYLCGEDPAFGFPKL---EQANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFL 129

Query: 151 QGDHTGHDFNMFRSQAGGACDCGDSNVMRESGFCKRHQIKSSSNIPCVPKDLLMMSEFVL 210
              H  H + M  S  GG CDCGD+   +E  +C++H++ ++S I      L+ +SE V+
Sbjct: 130 GSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHEL-NTSEIEEEEDPLVHLSEDVI 188

Query: 211 PR 212
            R
Sbjct: 189 AR 190


>gi|28372497 ubiquitin protein ligase E3 component n-recognin 1
           [Homo sapiens]
          Length = 1749

 Score =  129 bits (324), Expect = 3e-29
 Identities = 143/632 (22%), Positives = 288/632 (45%), Gaps = 91/632 (14%)

Query: 382 LEELLFWTIK-YEFPQKMVTFLL--NMLPDQEYKVAFTKTFVQHYAFIMKTLKKSHESDT 438
           +  L+ W  K Y+  +K++  L+  +   + EYK  F   FV++Y    K L+K + SD 
Sbjct: 352 ISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYY----KQLQKEYISDD 407

Query: 439 --MSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMESCLIKSEL-------QD 489
              S  I  +SVQ+F+   LAR + EE  ++ ++   LL ++   L ++         QD
Sbjct: 408 HDRSISITALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQD 467

Query: 490 EENSLHVVV-NCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHGLLVTWMNFVSFFQ 548
           +   ++ V+ +    L+   T W            + +  +FLE      +++  ++  Q
Sbjct: 468 KLGRVYAVICDLKYILISKPTIWT-----------ERLRMQFLEGFR---SFLKILTCMQ 513

Query: 549 GMNLNKRELNEHVEFESQTYYAAFAAELE------------ACAQPMWGLLSHCKVRETQ 596
           GM   +R++ +H+E +   + AA A +++            AC + +  L+++ +  +  
Sbjct: 514 GMEEIRRQVGQHIEVDPD-WEAAIAIQMQLKNILLMFQEWCACDEELL-LVAYKECHKAV 571

Query: 597 --------EYTRNVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPLHRYYAMFLSKAVKC 648
                     ++ VV+ C  +L+     ++       + V+ HLPL R  A    +  + 
Sbjct: 572 MRCSTSFISSSKTVVQSCGHSLETKSYRVS------EDLVSIHLPLSRTLAGLHVRLSRL 625

Query: 649 QELD-LDSVLPDQEMLMKLMI-HPLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCN 706
             +  L   +  ++  +++++ +PL+    +A++ + MW RNGL +  Q   Y       
Sbjct: 626 GAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCRE 685

Query: 707 SMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLL--TMASQHQNTVLDAEHERSMLEG 764
            M D DI +LQ+ AS +DP+ F+  V +R+++ +    T++++ Q+ +   +   +++E 
Sbjct: 686 EMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEAFNKTISTKDQDLI---KQYNTLIEE 742

Query: 765 ALTFLVILLSLRLHLGMSD---DEILRAEMVAQLCMNDRTHSSLLDLIPENPNPKSGIIP 821
            L  L+ ++  R   G+ +   +E+   E++  LC+    HS++   +PEN N ++G+  
Sbjct: 743 MLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENNETGL-- 800

Query: 822 GSYSFESVLSAVADFKAPVFEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSA 881
                E+V++ VA FK P     G    G+Y    E+ D+      +      +     A
Sbjct: 801 -----ENVINKVATFKKP-----GVSGHGVY----ELKDESLKDFNMYFYHYSKTQHSKA 846

Query: 882 MDRYTAFLKQSGKFPGNPWPPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQ 941
                   KQ  K    P PP        P++  ++ LL+C  +  +L T+  + +    
Sbjct: 847 EHMQKKRRKQENKDEALPPPP---PPEFCPAFSKVINLLNCDIMMYILRTVFERAIDTDS 903

Query: 942 NL-SEHVLCMVLYLIELGL--ENSAEEESDEE 970
           NL +E +L M  +++ LGL  E    +++ EE
Sbjct: 904 NLWTEGMLQMAFHILALGLLEEKQQLQKAPEE 935



 Score =  107 bits (267), Expect = 1e-22
 Identities = 73/245 (29%), Positives = 118/245 (48%), Gaps = 38/245 (15%)

Query: 1646 LQDFCLPFLRITSLLQHHLFG----EDLPSCQEEEEFSVLASCLGLLPT--------FYQ 1693
            L++   P+LR  +L  H+L G    E+L +   E E+S L S L L PT        ++ 
Sbjct: 1501 LKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSL-PTNLFLLFQEYWD 1559

Query: 1694 TEHPFISASCLDWPVPAFDIITQWCFEIKSFTERHAEQGKALLIQESKWKLPHLLQLPEN 1753
            T  P +   C D   PA       C + K+   R+  +  +L+            +LP++
Sbjct: 1560 TVRPLLQRWCAD---PAL----LNCLKQKNTVVRYPRKRNSLI------------ELPDD 1600

Query: 1754 YNTIF-QYYHRKTCSVCTKVPKDPAVCLVCGTFVCLKGLCCKQ----QSYCECVLHSQNC 1808
            Y+ +  Q  H +         K P +CL CG  +C + +CC++    +    C+ H+ +C
Sbjct: 1601 YSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHC 1660

Query: 1809 GAGTGIFLLINASVIIIIRGH-RFCLWGSVYLDAHGEEDRDLRRGKPLYICKERYKVLEQ 1867
            GAG  IFL I    ++++ G  R C + + YLD +GE D  L+RG PL++ +ERY+ L  
Sbjct: 1661 GAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHL 1720

Query: 1868 QWISH 1872
             W  H
Sbjct: 1721 VWQQH 1725



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 34/107 (31%), Positives = 53/107 (49%), Gaps = 7/107 (6%)

Query: 119 LCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVM 178
           LCG V+ +    Y CR C I P   LC +CF    H  H + M  S  GG CDCGD+   
Sbjct: 98  LCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAW 157

Query: 179 RESGFCKRHQ------IKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQ 219
           +   FC  H+      IK +S  P + +++++ +  + P  I  +++
Sbjct: 158 KTGPFCVNHEPGRAGTIKENSRCP-LNEEVIVQARKIFPSVIKYVVE 203



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 57/240 (23%), Positives = 105/240 (43%), Gaps = 27/240 (11%)

Query: 1150 KRIIEEICRKVTPPVPPKKVTAAE----KKTLDKEERRQKARERQQKLLAEFASRQKSFM 1205
            KR+ E+ C  V      + +   E    K+  +++ + + AR  +QK++A+ ++ QK+F+
Sbjct: 986  KRLREKSCLIVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFI 1045

Query: 1206 ETAMDVDSPENDIP-MEITTAEPQVSEAVYD---CVICGQSGPSSEDRPTGLVVLLQASS 1261
            ET   +    +++P  E +  E + + AV D     +  + GPS  ++     +L Q   
Sbjct: 1046 ETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQ 1105

Query: 1262 VLGQCRDNVEPKKLPISEEEQIYPWDTCAAVHDVRLS--LLQRYFKDSSCLLAVSIGWEG 1319
             +      +E   + +S   Q     T      + LS   L   F D             
Sbjct: 1106 EV-----KIENNAMVLSACVQKSTALTQHRGKPIELSGEALDPLFMDPDLAY-------- 1152

Query: 1320 GVYVQTCGHTLHIDCHKSYMESLRNDQV----LQGFSVDKGEFTCPLCRQFANSVLPCYP 1375
            G Y  +CGH +H  C + Y E+++        +  F ++ GE+ CPLC+   N+V+P  P
Sbjct: 1153 GTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIP 1212


>gi|55749544 SH3 multiple domains 1 [Homo sapiens]
          Length = 1105

 Score = 42.7 bits (99), Expect = 0.003
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 22/135 (16%)

Query: 1159 KVTPPVPPKKVTAAEKKTLDKEERRQKARERQQKLLAEFASRQKSFMETAMDVDSPENDI 1218
            KV PP PP K   AE+      E +   R+                    +  + PE DI
Sbjct: 493  KVPPPAPPSKPKEAEEGPTGASESQDSPRK--------------------LKYEEPEYDI 532

Query: 1219 PMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVVLLQASSVLGQCRDNVEPKKLPIS 1278
            P     +EP++SE   +    G+  P+   RP+    L +A   +G+  ++V  ++  I 
Sbjct: 533  PAFGFDSEPELSEEPVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIY 592

Query: 1279 EEEQIYPW--DTCAA 1291
            E E   P+  DT +A
Sbjct: 593  ENEGFRPYAEDTLSA 607


>gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3
           component n-recognin 5 isoform 2 [Homo sapiens]
          Length = 2277

 Score = 42.4 bits (98), Expect = 0.004
 Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 5/57 (8%)

Query: 120 CGLVWTA----NFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDC 172
           C   WT     N   + CRTCG+   +  C EC     H GHD+ + R+     CDC
Sbjct: 658 CSFTWTGAEHINQDIFECRTCGLLESLCCCTECAGV-CHKGHDWKLKRTSPTAYCDC 713


>gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3
            component n-recognin 5 isoform 1 [Homo sapiens]
          Length = 2796

 Score = 42.4 bits (98), Expect = 0.004
 Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 5/57 (8%)

Query: 120  CGLVWTA----NFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDC 172
            C   WT     N   + CRTCG+   +  C EC     H GHD+ + R+     CDC
Sbjct: 1177 CSFTWTGAEHINQDIFECRTCGLLESLCCCTECAGV-CHKGHDWKLKRTSPTAYCDC 1232


>gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [Homo
            sapiens]
          Length = 2799

 Score = 42.0 bits (97), Expect = 0.006
 Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 5/57 (8%)

Query: 120  CGLVWTA----NFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDC 172
            C   WT     N   + CRTCG+   +  C EC  +  H GHD  + R+     CDC
Sbjct: 1179 CSFTWTGAEHINQDIFECRTCGLLESLCCCTEC-ARVCHKGHDCKLKRTSPTAYCDC 1234


>gi|64276486 serologically defined colon cancer antigen 10 [Homo
            sapiens]
          Length = 472

 Score = 40.4 bits (93), Expect = 0.016
 Identities = 53/227 (23%), Positives = 96/227 (42%), Gaps = 22/227 (9%)

Query: 1095 KLHHKLSGKQNSYYPPWLDDIEILIQPEIPK--------YSHGDGITAVERILLKAASQS 1146
            ++   + GK  S +    DD  +   P +             G+  +A     +    ++
Sbjct: 220  RVSQSMKGKSKSSHDLLKDDPHLSSVPVVESEKGDAPDLVDDGEDESAEHDEYIDGDEKN 279

Query: 1147 RMNKRIIEEICRKVTPPVPPKKVTAAEKKTLDK-EERRQKARERQQKLLAEFASRQKSFM 1205
             M +RI +++ +  +  V        EKK++ + EE R++AR+ +++LL   A++QK   
Sbjct: 280  LMRERIAKKLKKDTSANVKSAGEGEVEKKSVSRSEELRKEARQLKRELL---AAKQKKVE 336

Query: 1206 ETAMDVD--SPENDIPMEITTAEPQVSEAVYDCVICGQS--GPSSEDRPTGLVVLLQASS 1261
              A   +  S E + P +   AE +  +  Y+ +   QS  G S ED+   L +L Q  S
Sbjct: 337  NAAKQAEKRSEEEEAPPDGAVAEYRREKQKYEALRKQQSKKGTSREDQT--LALLNQFKS 394

Query: 1262 VLGQCRDNVEPKKLPISEEEQIYPWDTCAAVHDVRLSLLQRYFKDSS 1308
             L Q         +P +E E    W +    H ++     R  KD+S
Sbjct: 395  KLTQAIAETPENDIPETEVEDDEGWMS----HVLQFEDKSRKVKDAS 437


>gi|28875784 armadillo repeat containing 5 isoform b [Homo sapiens]
          Length = 725

 Score = 40.4 bits (93), Expect = 0.016
 Identities = 34/94 (36%), Positives = 44/94 (46%), Gaps = 6/94 (6%)

Query: 1   MAAAAAAAVGGQQ-PSQPELPAPGLALDKAATAAHLKAA--LSRPDNRAGAEELQALLER 57
           +AAAA  A+GG++ P+  E P     L  A    H+KAA  + R   R G   L ALL R
Sbjct: 19  LAAAAGEALGGEKDPATNETPLSRALL--ALRTRHIKAAGGIERFRARGGLRPLLALLRR 76

Query: 58  VLSA-ERPLAAAAGGEDAAAAGGGGGPGAAEEEA 90
             +A   P  A  G   ++AA G   P  A   A
Sbjct: 77  AAAAGSAPSQAGPGSAPSSAASGASSPAPASGPA 110


>gi|157426856 armadillo repeat containing 5 isoform a [Homo sapiens]
          Length = 935

 Score = 40.4 bits (93), Expect = 0.016
 Identities = 34/94 (36%), Positives = 44/94 (46%), Gaps = 6/94 (6%)

Query: 1   MAAAAAAAVGGQQ-PSQPELPAPGLALDKAATAAHLKAA--LSRPDNRAGAEELQALLER 57
           +AAAA  A+GG++ P+  E P     L  A    H+KAA  + R   R G   L ALL R
Sbjct: 19  LAAAAGEALGGEKDPATNETPLSRALL--ALRTRHIKAAGGIERFRARGGLRPLLALLRR 76

Query: 58  VLSA-ERPLAAAAGGEDAAAAGGGGGPGAAEEEA 90
             +A   P  A  G   ++AA G   P  A   A
Sbjct: 77  AAAAGSAPSQAGPGSAPSSAASGASSPAPASGPA 110


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 39.3 bits (90), Expect = 0.037
 Identities = 35/89 (39%), Positives = 42/89 (47%), Gaps = 13/89 (14%)

Query: 4   AAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDN-RAGAEELQAL----LERV 58
           +A  A G   P     P+PG +  KAA  A   A+   P   R G   L AL    ++ +
Sbjct: 714 SATPAPGALDPG----PSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHL 769

Query: 59  LSAERPLAAAAGGEDAAAAGGGGGPGAAE 87
           LS    LAAA G    AA G GGGPG AE
Sbjct: 770 LSRTLLLAAAEG----AAGGSGGGPGGAE 794


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 39.3 bits (90), Expect = 0.037
 Identities = 35/89 (39%), Positives = 42/89 (47%), Gaps = 13/89 (14%)

Query: 4    AAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDN-RAGAEELQAL----LERV 58
            +A  A G   P     P+PG +  KAA  A   A+   P   R G   L AL    ++ +
Sbjct: 983  SATPAPGALDPG----PSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHL 1038

Query: 59   LSAERPLAAAAGGEDAAAAGGGGGPGAAE 87
            LS    LAAA G    AA G GGGPG AE
Sbjct: 1039 LSRTLLLAAAEG----AAGGSGGGPGGAE 1063


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 39.3 bits (90), Expect = 0.037
 Identities = 35/89 (39%), Positives = 42/89 (47%), Gaps = 13/89 (14%)

Query: 4   AAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDN-RAGAEELQAL----LERV 58
           +A  A G   P     P+PG +  KAA  A   A+   P   R G   L AL    ++ +
Sbjct: 675 SATPAPGALDPG----PSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHL 730

Query: 59  LSAERPLAAAAGGEDAAAAGGGGGPGAAE 87
           LS    LAAA G    AA G GGGPG AE
Sbjct: 731 LSRTLLLAAAEG----AAGGSGGGPGGAE 755


>gi|239787919 low density lipoprotein receptor-related protein 11
           [Homo sapiens]
          Length = 500

 Score = 37.4 bits (85), Expect = 0.14
 Identities = 40/133 (30%), Positives = 51/133 (38%), Gaps = 25/133 (18%)

Query: 1   MAAAAAAAVGGQQPSQPE-------------LPAPGLALDKAATAAHLKAALSRPDNRAG 47
           MA+ A  + G Q+   P              LP+   AL  AA  + L A LS      G
Sbjct: 1   MASVAQESAGSQRRLPPRHGALRGLLLLCLWLPSGRAALPPAAPLSELHAQLS------G 54

Query: 48  AEELQALLERVLSAERPLAA------AAGGEDAAAAGGGGGPGAAEEEALEWCKCLLAGG 101
            E+L     R L  ERP         A GG      G G G  +A  +A+   K  LA G
Sbjct: 55  VEQLLEEFRRQLQQERPQEELELELRAGGGPQEDCPGPGSGGYSAMPDAIIRTKDSLAAG 114

Query: 102 GGYDEFCAAVRAY 114
             +    AAVR +
Sbjct: 115 ASFLRAPAAVRGW 127


>gi|122937319 even-skipped homeobox 2 [Homo sapiens]
          Length = 476

 Score = 36.6 bits (83), Expect = 0.24
 Identities = 30/109 (27%), Positives = 38/109 (34%), Gaps = 13/109 (11%)

Query: 2   AAAAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLSA 61
           A AAAA +     +     A   A   AA A    +  S P +       Q+      +A
Sbjct: 346 APAAAAGLNSAASAAAAAAAAAAAASSAAAAGAPPSGGSAPCSCLSCHSSQSAAAAAAAA 405

Query: 62  ERPLAAAAGGEDAAAAGGGGGPGAAEEEALEWCKCLLAGGGGYDEFCAA 110
              L +  GG      GGGGG GA               GGG D  C+A
Sbjct: 406 AAALGSRGGGGGGGGGGGGGGGGA-------------GAGGGSDFGCSA 441


>gi|4504713 insulinoma-associated 1 [Homo sapiens]
          Length = 510

 Score = 36.6 bits (83), Expect = 0.24
 Identities = 37/104 (35%), Positives = 43/104 (41%), Gaps = 17/104 (16%)

Query: 1   MAAAAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAE-ELQALLERVL 59
           +AAA A A G Q P Q     P  A      AAH  A L  P      E E     ER  
Sbjct: 66  LAAALACAPGPQPPPQ----GPRAAHFGNPEAAH-PAPLYSPTRPVSREHEKHKYFERSF 120

Query: 60  SAERPLAAAAGGEDAAAAGGGGGPGAAEEEALEWCKCLLAGGGG 103
           +   P++A +    AA  GGGGG GA+            AGGGG
Sbjct: 121 NLGSPVSAESFPTPAALLGGGGGGGASG-----------AGGGG 153


>gi|33457336 chromosome 14 open reading frame 4 [Homo sapiens]
          Length = 796

 Score = 36.6 bits (83), Expect = 0.24
 Identities = 30/93 (32%), Positives = 39/93 (41%), Gaps = 11/93 (11%)

Query: 2   AAAAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALS------RPDNRAGAEELQALL 55
           AAAAAAA   +Q S+ E P P ++L  ++  A L   L       +P    G  EL    
Sbjct: 156 AAAAAAAAAVEQRSRFEYPPPPVSLGSSSHTARLPNGLGGPNGFPKPTPEEGPPELNRQS 215

Query: 56  ERVLSAERPLAAAAGGEDAAAA-----GGGGGP 83
               SA   +A+  G            GGGGGP
Sbjct: 216 PNSSSAAASVASRRGTHGGLVTGLPNPGGGGGP 248


>gi|55749531 splicing factor 3B subunit 2 [Homo sapiens]
          Length = 895

 Score = 36.2 bits (82), Expect = 0.31
 Identities = 32/124 (25%), Positives = 58/124 (46%), Gaps = 19/124 (15%)

Query: 1119 IQPEIPKYSHGDGITAVERIL-LKAASQSRMNKRIIEEICRKVTPPVPPKKVTAAEKKTL 1177
            + P+IP+        A+E+IL LK + Q  MN +  EE           +  +  E+ T+
Sbjct: 265  VGPKIPQ--------ALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTV 316

Query: 1178 D--KEERRQKARERQQK--------LLAEFASRQKSFMETAMDVDSPENDIPMEITTAEP 1227
               K+E+ +K R R++K        + +E +  ++     +   DSP  D+ +E  T EP
Sbjct: 317  SVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEP 376

Query: 1228 QVSE 1231
            ++ E
Sbjct: 377  EIYE 380


>gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens]
          Length = 739

 Score = 35.8 bits (81), Expect = 0.41
 Identities = 27/69 (39%), Positives = 35/69 (50%), Gaps = 7/69 (10%)

Query: 17 PELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLSAERPLAAAAGGEDAAA 76
          P  P+ G A    A AA   AA +  +     EE + LL+ + +AE   AAAAG    AA
Sbjct: 5  PAEPSAGPAAGGEAVAA---AAATEEEE----EEARQLLQTLQAAEGEAAAAAGAGAGAA 57

Query: 77 AGGGGGPGA 85
          A G  GPG+
Sbjct: 58 AAGAEGPGS 66


>gi|24497554 homeobox A13 [Homo sapiens]
          Length = 388

 Score = 35.4 bits (80), Expect = 0.53
 Identities = 45/147 (30%), Positives = 59/147 (40%), Gaps = 27/147 (18%)

Query: 2   AAAAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLSA 61
           AAAAAAA   Q  +    PAP   L   A +A+  A    P + A A    A        
Sbjct: 76  AAAAAAAAANQCRNLMAHPAP---LAPGAASAYSSAPGEAPPSAAAAAAAAA-------- 124

Query: 62  ERPLAAAAGGEDAAAAGGGGGPGAAEEEALEWCKCLLAGGGGYDEFCAAVRAYDPAALCG 121
               AAAA    A+++GG G  G A  EA + C    A         AA  +  PAAL  
Sbjct: 125 ----AAAAAAAAASSSGGPGPAGPAGAEAAKQCSPCSA---------AAQSSSGPAALPY 171

Query: 122 LVWTANFVAYRCRTCGISP-CMSLCAE 147
             + + +  Y C   G  P  +  CA+
Sbjct: 172 GYFGSGY--YPCARMGPHPNAIKSCAQ 196


>gi|27262632 neural stem cell-derived dendrite regulator [Homo
           sapiens]
          Length = 1042

 Score = 35.4 bits (80), Expect = 0.53
 Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 4/76 (5%)

Query: 17  PELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQALL-ERVLSAERPLAAAAGGEDAA 75
           P +P    +L   ++   L AA S   +    + L+A L    ++ ERP +AAA  E+  
Sbjct: 825 PAIPEENPSL---SSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEE 881

Query: 76  AAGGGGGPGAAEEEAL 91
             GGGGGP +  E AL
Sbjct: 882 VGGGGGGPASRGELAL 897


>gi|153791670 keratin 76 [Homo sapiens]
          Length = 638

 Score = 35.0 bits (79), Expect = 0.69
 Identities = 51/251 (20%), Positives = 105/251 (41%), Gaps = 34/251 (13%)

Query: 843  PGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSAMDRYTAF------LKQSGKFP 896
            PGG  +  +     +  + E DP +  ++   R  +++  +++ +F      L+Q  K  
Sbjct: 152  PGGIQEVIVNQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVL 211

Query: 897  GNPWPPYKKRT------SLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQNLSEHVLCM 950
               W   +++T      SL P ++  +  L CK L          +L +  NL   +  M
Sbjct: 212  ETKWELLQQQTTGSGPSSLEPCFESYISFL-CKQLD--------SLLGERGNLEGELKSM 262

Query: 951  --VLYLIELGLENSAEEESDEEASVGGPERCHDSWFPGS----NLVSNMRHFINYVRVRV 1004
              ++   +   E+   + +  E    G ++  D+ F         V ++   ++++R   
Sbjct: 263  QDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLR--- 319

Query: 1005 PETAPEVKRDSPASTSSDN--LGSLQNSGTAQVFSLVAERRKKFQEIINRSSSEANQVVR 1062
              T  E++     S +SD   + S+ N+    + S++AE R +++EI  RS SEA  + +
Sbjct: 320  --TLYEMELSQMQSHASDTSVVLSMDNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQ 377

Query: 1063 PKTSSKWSAPG 1073
             K     +  G
Sbjct: 378  TKLGELQTTAG 388


>gi|40288197 GATA binding protein 6 [Homo sapiens]
          Length = 595

 Score = 35.0 bits (79), Expect = 0.69
 Identities = 29/89 (32%), Positives = 37/89 (41%), Gaps = 4/89 (4%)

Query: 2   AAAAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLSA 61
           +AAAAAA      S   +P   +         HL+ + S P N AG         +  SA
Sbjct: 172 SAAAAAAAAAAASSPVYVPTTRVGSMLPGLPYHLQGSGSGPANHAGGAGAHPGWPQA-SA 230

Query: 62  ERPLAAAAGGEDAAAAGGGGGPGAAEEEA 90
           + P   + GG   AA GG  GPG A   A
Sbjct: 231 DSPPYGSGGG---AAGGGAAGPGGAGSAA 256


>gi|4758392 forkhead box D1 [Homo sapiens]
          Length = 465

 Score = 35.0 bits (79), Expect = 0.69
 Identities = 44/136 (32%), Positives = 49/136 (36%), Gaps = 28/136 (20%)

Query: 2   AAAAAAAVGGQQPSQPELPAP--GLALDKAATA---------AHLKAALSRPDNRAGAEE 50
           AAAAAAA     P  P  P P  G A + A TA         A L   L     +AG   
Sbjct: 294 AAAAAAAAAAFHPHSPPPPPPPHGAAAELARTAFGYRPHPLGAALPGPLPASAAKAGGPG 353

Query: 51  LQALLERVLSAERPL--------AAAAGGEDAAAAGGGGGPGAAEEEALEWCKCLLAGGG 102
             AL     S E  +        AAAA  + AAAA     P               + GG
Sbjct: 354 ASALARSPFSIESIIGGSLGPAAAAAAAAQAAAAAQASPSPSPVAAPPAPG-----SSGG 408

Query: 103 GYDEFCAAVRAYDPAA 118
           G    CAA  A  PAA
Sbjct: 409 G----CAAQAAVGPAA 420


>gi|239757043 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 996

 Score = 34.7 bits (78), Expect = 0.91
 Identities = 30/92 (32%), Positives = 36/92 (39%), Gaps = 8/92 (8%)

Query: 1   MAAAAAAAVGGQ--------QPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQ 52
           +AAAAA A GG          P  P  P P LA    A  AH K      D+ +  E   
Sbjct: 264 VAAAAAVAGGGGLLGPHLLGAPPPPPPPPPPLAELAGAPHAHHKRPRFDDDDDSLQEAAV 323

Query: 53  ALLERVLSAERPLAAAAGGEDAAAAGGGGGPG 84
                + +A   L+ AA    A   GGG G G
Sbjct: 324 VAAASLSAAAASLSVAAASGGAGTGGGGAGGG 355


>gi|239751555 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 1252

 Score = 34.7 bits (78), Expect = 0.91
 Identities = 30/92 (32%), Positives = 36/92 (39%), Gaps = 8/92 (8%)

Query: 1   MAAAAAAAVGGQ--------QPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQ 52
           +AAAAA A GG          P  P  P P LA    A  AH K      D+ +  E   
Sbjct: 264 VAAAAAVAGGGGLLGPHLLGAPPPPPPPPPPLAELAGAPHAHHKRPRFDDDDDSLQEAAV 323

Query: 53  ALLERVLSAERPLAAAAGGEDAAAAGGGGGPG 84
                + +A   L+ AA    A   GGG G G
Sbjct: 324 VAAASLSAAAASLSVAAASGGAGTGGGGAGGG 355


>gi|239746067 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 1252

 Score = 34.7 bits (78), Expect = 0.91
 Identities = 30/92 (32%), Positives = 36/92 (39%), Gaps = 8/92 (8%)

Query: 1   MAAAAAAAVGGQ--------QPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQ 52
           +AAAAA A GG          P  P  P P LA    A  AH K      D+ +  E   
Sbjct: 264 VAAAAAVAGGGGLLGPHLLGAPPPPPPPPPPLAELAGAPHAHHKRPRFDDDDDSLQEAAV 323

Query: 53  ALLERVLSAERPLAAAAGGEDAAAAGGGGGPG 84
                + +A   L+ AA    A   GGG G G
Sbjct: 324 VAAASLSAAAASLSVAAASGGAGTGGGGAGGG 355


>gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens]
          Length = 843

 Score = 34.3 bits (77), Expect = 1.2
 Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 2/43 (4%)

Query: 131 YRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCG 173
           YRC TC  +   ++C  C  +  H GHD    R      CDCG
Sbjct: 767 YRCHTCNTTDRNAICVNCIKK-CHQGHDVEFIRHDR-FFCDCG 807


>gi|91208420 bassoon protein [Homo sapiens]
          Length = 3926

 Score = 33.9 bits (76), Expect = 1.5
 Identities = 32/93 (34%), Positives = 38/93 (40%), Gaps = 25/93 (26%)

Query: 4    AAAAAVGGQQPSQPELPAPGLALDK---AATAAHLKAALSRPDNRAGAEELQALLERVLS 60
            AAA A G   PS+PE+P  G A ++     T A +K A   P                  
Sbjct: 2286 AAAKAPGAGGPSRPEMPV-GAAREEPLPTTTPAAIKEAAGAP------------------ 2326

Query: 61   AERPLAAAAGGEDAAAAGGGGG---PGAAEEEA 90
            A  PLA      DAA  GG G    PG  +EEA
Sbjct: 2327 APAPLAGQKPPADAAPGGGSGALSRPGFEKEEA 2359


>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
            sapiens]
          Length = 816

 Score = 33.5 bits (75), Expect = 2.0
 Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 6/88 (6%)

Query: 1110 PWLDDIEILIQPEIPKYSHG----DG-ITAVERILLKAASQSRMNKRIIEEICRKVTPPV 1164
            P  D I++ +QP  P         DG I+   +  LKAA    +  R+ +     +  P 
Sbjct: 444  PAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPE 503

Query: 1165 PPKKVTAAEKKTLDKEERRQKARERQQK 1192
            P K VTA E++  ++EE+R++ +ER ++
Sbjct: 504  PRKPVTAQERQR-EREEKRRRRQERAKE 530


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,664,046
Number of Sequences: 37866
Number of extensions: 3579488
Number of successful extensions: 14177
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 13849
Number of HSP's gapped (non-prelim): 306
length of query: 1888
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1771
effective length of database: 13,817,196
effective search space: 24470254116
effective search space used: 24470254116
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.