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Search of human proteins with 158321897
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo
sapiens]
(1200 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 2431 0.0
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 709 0.0
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 494 e-139
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 490 e-138
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 471 e-132
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 463 e-130
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 463 e-130
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 452 e-127
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 443 e-124
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 421 e-117
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 417 e-116
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 414 e-115
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 409 e-114
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 397 e-110
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 396 e-110
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 370 e-102
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 363 e-100
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 322 1e-87
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 322 1e-87
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 322 1e-87
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 322 2e-87
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 322 2e-87
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 238 3e-62
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 237 6e-62
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 237 6e-62
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 237 6e-62
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 237 6e-62
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 237 6e-62
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 237 6e-62
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 237 6e-62
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 2431 bits (6300), Expect = 0.0
Identities = 1200/1200 (100%), Positives = 1200/1200 (100%)
Query: 1 MKVAGGLELGAAALLSASPRALVTLSTGPTCSILPKNPLFPQNLSSQPCIKMEGDKSLTF 60
MKVAGGLELGAAALLSASPRALVTLSTGPTCSILPKNPLFPQNLSSQPCIKMEGDKSLTF
Sbjct: 1 MKVAGGLELGAAALLSASPRALVTLSTGPTCSILPKNPLFPQNLSSQPCIKMEGDKSLTF 60
Query: 61 SSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGAS 120
SSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGAS
Sbjct: 61 SSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGAS 120
Query: 121 LAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSA 180
LAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSA
Sbjct: 121 LAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSA 180
Query: 181 TAAETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVM 240
TAAETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVM
Sbjct: 181 TAAETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVM 240
Query: 241 TKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIV 300
TKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIV
Sbjct: 241 TKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIV 300
Query: 301 LCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFI 360
LCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFI
Sbjct: 301 LCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFI 360
Query: 361 IDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSE 420
IDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSE
Sbjct: 361 IDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSE 420
Query: 421 VVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVA 480
VVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVA
Sbjct: 421 VVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVA 480
Query: 481 LQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW 540
LQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW
Sbjct: 481 LQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW 540
Query: 541 NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEG 600
NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEG
Sbjct: 541 NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEG 600
Query: 601 LEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLG 660
LEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLG
Sbjct: 601 LEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLG 660
Query: 661 VKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDL 720
VKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDL
Sbjct: 661 VKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDL 720
Query: 721 IASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTH 780
IASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTH
Sbjct: 721 IASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTH 780
Query: 781 PHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLR 840
PHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLR
Sbjct: 781 PHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLR 840
Query: 841 SLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLS 900
SLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLS
Sbjct: 841 SLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLS 900
Query: 901 LAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSN 960
LAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSN
Sbjct: 901 LAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSN 960
Query: 961 NSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPV 1020
NSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPV
Sbjct: 961 NSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPV 1020
Query: 1021 EDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDG 1080
EDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDG
Sbjct: 1021 EDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDG 1080
Query: 1081 GVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMM 1140
GVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMM
Sbjct: 1081 GVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMM 1140
Query: 1141 KLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHSFDEDDRYWWKN 1200
KLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHSFDEDDRYWWKN
Sbjct: 1141 KLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHSFDEDDRYWWKN 1200
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 709 bits (1830), Expect = 0.0
Identities = 429/1149 (37%), Positives = 636/1149 (55%), Gaps = 64/1149 (5%)
Query: 53 EGDKSLTFSSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALL 112
+ S F +GL L EL+KEE TFK L K++ E P E++ A E LA L
Sbjct: 3 DSSSSSFFPDFGLLLYLEELNKEELNTFK-LFLKETMEPEHGLTPWNEVKKARREDLANL 61
Query: 113 LHEYYGASLAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGIS 172
+ +YY AW+ S+ IF MNL+ L E+A KE++ +
Sbjct: 62 MKKYYPGEKAWSVSLKIFGKMNLKDLCERA----------------------KEEINWSA 99
Query: 173 QAVQQDSATAAETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDT 232
Q + D A A ET+E +QE TE + ++++ T
Sbjct: 100 QTIGPDDAKAGETQE-------DQEAVLGDGTEYR---NRIKEKFCI------------T 137
Query: 233 WDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSD-RWGFRPRTVVLHGKSGIG 291
WD KS + ED F + A+ + + L FD D + G +P+ VVL G +G+G
Sbjct: 138 WDKKSLA----GKPED----FHHGIAE-KDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVG 188
Query: 292 KSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIM 351
K+ L R+ +L WA+G LYQ F YVF+L RE+ + KE S + IS++WP ++ P+ EIM
Sbjct: 189 KTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIM 248
Query: 352 SRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVR 410
+P LLFIID FD+L + LC+DW ++ P L+ SLLRKV+LPE+ L+VT R
Sbjct: 249 YQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTR 308
Query: 411 DVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQV 470
+++LK + + Y+ + G+S + R + + + + ++ +N L CQV
Sbjct: 309 LTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQV 368
Query: 471 PAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKR 530
P V C L+ Q G V QT T L ++ TP V +L + L+R
Sbjct: 369 PLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTP--VDGGSPSLPNQAQLRR 426
Query: 531 FCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDF 590
C++A +G+W VF ++L GL +S++ + NI+ D+ E Y F HL +Q+F
Sbjct: 427 LCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEF 486
Query: 591 CAALYYVLEG-LEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPL 649
AA++Y+L+G E C + + +S+ + H MK FLFGL++ED + L
Sbjct: 487 FAAMFYMLKGSWEAGNPSCQPF--EDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQL 544
Query: 650 EVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQE 709
E C + L +K KLL + +LG + + L+ FHCL+ETQDK F+ A+ F +
Sbjct: 545 ERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPK 604
Query: 710 VWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQ 769
V + I + + L+ SSFCL+HC LR IR+ V +F + + P W D+ I
Sbjct: 605 VAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLP-TNTWDGDR--ITHC 661
Query: 770 WEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHL 829
W+D CS+L T+ HLR+LDL S L + AM L +LRHP CK+Q L+ + G Q +
Sbjct: 662 WQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDI 721
Query: 830 WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQI 889
++ N+NL L+L G+ + + V+ CEALKHP+C L++LRL+ C LT C L IS
Sbjct: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
Query: 890 LTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVS 949
L S SL L+L+ N + D GV L +ALR +C L++L LE CG+T GC+ L+ AL+S
Sbjct: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
Query: 950 NRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSW 1009
N+ LTHLCL++N LG+ GV L+ +++ C+L+ L+L +CH + +L+ +L+ N
Sbjct: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
Query: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069
LTHL L N ++DNGVKLLC+V R PSC+LQDLEL+ C LT ACC L+ VI + +L+S
Sbjct: 902 LTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRS 961
Query: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129
LDL +N L D GV LC+ L+ N + RLGL+ CGLTS CC+ LS AL CN+ L +NL
Sbjct: 962 LDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNL 1021
Query: 1130 VQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHS 1189
QN +G++KL P LQ++GL K + + +KLLE V + P ++I +
Sbjct: 1022 TQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCNY 1081
Query: 1190 FDEDDRYWW 1198
+E+D WW
Sbjct: 1082 HNEEDVSWW 1090
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 494 bits (1273), Expect = e-139
Identities = 344/1053 (32%), Positives = 522/1053 (49%), Gaps = 55/1053 (5%)
Query: 69 LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128
L EL+ E + FK L ++E IP +E A +A LL ++G AW ++S
Sbjct: 17 LEELEAVELKKFK-LYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALS 75
Query: 129 IFENMNLRTLSEKA-RDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKE 187
FE +N + L E+ R+D+ R +P +++ +Q +V ++ ++D
Sbjct: 76 TFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTP--RKDPQETYRDYV 133
Query: 188 QEISQAMEQEGATAAET---EEQEISQAMEQEGATAAETEEQ------GHGGDTWDYKSH 238
+ + ME A E + + +E + + ++Q GH S
Sbjct: 134 RRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASP 193
Query: 239 VMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARR 298
+ + E D R PE PRTVV+ G +GIGKS LA +
Sbjct: 194 IKIETLFEPDEER---------PEP---------------PRTVVMQGAAGIGKSMLAHK 229
Query: 299 IVLCWAQGGLYQGMFSYVFFLPVREM-QRKKESSVTEFISREWPDSQAPVTEIMSRPERL 357
++L WA G L+QG F Y+F++ REM Q E S+ + I WP+ AP+ E++ PERL
Sbjct: 230 VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL 289
Query: 358 LFIIDGFDDLGSVLNNDT-KLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEK 416
LFIIDGFD+L ++ C W EK+P L+ SL+RK LLPE L++T R EK
Sbjct: 290 LFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEK 349
Query: 417 LKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSL 476
L + PR++ + G S +R + Q Q + +N L C VP V +
Sbjct: 350 LHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWV 409
Query: 477 ICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAV 536
+C LQ Q G + ++T T ++ ++ + P+ R L+ + C +A
Sbjct: 410 VCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPR---LQPPPNQRGLCSLAA 466
Query: 537 EGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYY 596
+G+WN+K +F+ DL GL ++ A +MNI D +CE YY+F HLS Q+F AA+YY
Sbjct: 467 DGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYY 526
Query: 597 VLEGLEIEPALCP-LYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGC 655
+L+ E E P V + + F RFLFGL++E+ R LE L
Sbjct: 527 ILD--EGEGGAGPDQDVTRLLTEYAFSERSF---LALTSRFLFGLLNEETRSHLEKSLCW 581
Query: 656 PVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLP-I 714
V +K LL W+ Q +T +L+ F CL+E Q++EF++ AL+ FQ + + I
Sbjct: 582 KVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNI 641
Query: 715 NQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACP----VVPLWMRDKT-LIEEQ 769
++ + SSFCL+ C + + + E C + + + ++T L++
Sbjct: 642 ASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAY 701
Query: 770 WEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGV-QH 828
E + L T+P+L +L L + L R +K LC LRHP CK+Q L + +I+ +
Sbjct: 702 SEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACED 761
Query: 829 LWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQ 888
L ++AN+NL ++L G + + + CE L+HP+C L+ ++L C L +++
Sbjct: 762 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 821
Query: 889 ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948
+L T+P L L L GN + D G+ L LR C L+ L L+ C +TA C LAS L
Sbjct: 822 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 881
Query: 949 SNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNS 1008
N+SL L LS N LG+ GV LLC +R P C LQ L L C L +A C L++ L N
Sbjct: 882 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANH 941
Query: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068
L L LS N + D G+ LL E ++ P+C LQ L L C LTA CE+L + ++ L
Sbjct: 942 NLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLT 1001
Query: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGL 1101
L LT+NALGD GV LC+ L L L L
Sbjct: 1002 DLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 1034
Score = 78.6 bits (192), Expect = 3e-14
Identities = 47/114 (41%), Positives = 60/114 (52%)
Query: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
L A E L+ + + +L L L NALG GV LC+GL+ N L L LK C ++S
Sbjct: 697 LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
Query: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQ 1162
CE LS AL N++LT ++L N GMM LC P LQ+I L K Q
Sbjct: 757 SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQ 810
Score = 55.5 bits (132), Expect = 3e-07
Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 1/127 (0%)
Query: 771 EDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITP-GVQHL 829
E +L + +LR+LDL + L + + L L+HP C++Q L + +T ++L
Sbjct: 931 EGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENL 990
Query: 830 WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQI 889
+ + N+ L L L L + VR+ C+ L HP C L L L L + +++ +
Sbjct: 991 YFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAAL 1050
Query: 890 LTTSPSL 896
T P L
Sbjct: 1051 RVTKPYL 1057
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 490 bits (1261), Expect = e-138
Identities = 344/1065 (32%), Positives = 535/1065 (50%), Gaps = 59/1065 (5%)
Query: 61 SSYGLQWCLYELDKEEFQTFKELLKKK-------SSESTTCSIPQFEIENANVECLALLL 113
++ GL L LD+ + + FK L+ + + + IP + A+ L+ LL
Sbjct: 13 TNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLL 72
Query: 114 HEYYGASLAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQ 173
E++ AW + IF+ MNL +L EK R +MK + T Q P++E + +
Sbjct: 73 DEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQ-----TQELQDPTQEDLEMLEA 127
Query: 174 AVQQDSATAAETKEQEISQAMEQEG----ATAAETEEQEISQAMEQEGATAAETEE-QGH 228
A + QE +E+E A + QE + +E+ E +
Sbjct: 128 AAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAE 187
Query: 229 GGDTWDY----KSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVL 284
+TWD K HV + NT+ D E + L D +R + +T+VL
Sbjct: 188 LLETWDNISWPKDHVYIR------------NTSKD--EHEELQRLLDPNRTRAQAQTIVL 233
Query: 285 HGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQ 344
G++G+GK+ LA + +L WA G L+Q FSYVF+L +++ KE++ E IS +WPD
Sbjct: 234 VGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFD 293
Query: 345 APVTEIMSRPERLLFIIDGFDDL-----GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVL 399
AP+ E MS+PE+LLFIIDGF+++ S +D C DW ++ P ++ SLL+K L
Sbjct: 294 APIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKEL 353
Query: 400 LPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIM 459
+P + L++T++ LK+ +V+P ++ + G +G+ + + + L+ +
Sbjct: 354 VPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLR 413
Query: 460 NNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRC 519
N L C P V +C L+ V + QT T L+A F + + V
Sbjct: 414 KNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLAD 473
Query: 520 LNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEY 579
+ + + C +A+EG+W+ F+ +D ++GL + +L+ NIL + C
Sbjct: 474 DSWPGQ--WRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGC 531
Query: 580 YTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKR-SMELKQAGFHIHSLW--MKRF 636
TF HLS Q+F AA+ +VLE EP P + K + M L+ + W + F
Sbjct: 532 TTFTHLSFQEFFAAMSFVLE----EPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLF 587
Query: 637 LFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQD 696
FGL+++++ R LE L C + V ++LL W LG+ +A+ L FHCL E+Q+
Sbjct: 588 FFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQE 647
Query: 697 KEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKG-IFPRDESAEACPV 755
++F + L EV L I ++ +L ASSFCL+HC L K+R+ V I RD +
Sbjct: 648 EDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERD-----LEI 702
Query: 756 VPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTL 815
+ D + W CS L T+ +L +LDL +S L ++K LC L++P CK+Q L
Sbjct: 703 LETSKFDSRM--HAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKL 760
Query: 816 MFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDC 875
++ +Q L + N L LN L V + +AL+H C L+ L L+
Sbjct: 761 TCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKL-GMTVPLILKALRHSACNLKYLCLEK 819
Query: 876 CGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGI 935
C L+ A ++ LT+ + L L N++ D G+ L AL +CAL++L L C +
Sbjct: 820 CNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQL 879
Query: 936 TATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTA 995
A C+ L+ AL+ NRSLTHL LS NSL +EGV LC ++ P +LQ L L+ C
Sbjct: 880 AAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
Query: 996 GCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCE 1055
GCG LA AL N + L L N ++D+GVKLLCE ++ P L L L KC+LT ACC+
Sbjct: 940 GCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQ 998
Query: 1056 SLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLG 1100
L V+S S+ L +L+L N L GV LC+ LK+ L +LG
Sbjct: 999 HLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
Score = 129 bits (324), Expect = 2e-29
Identities = 82/217 (37%), Positives = 117/217 (53%), Gaps = 2/217 (0%)
Query: 942 SLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLA 1001
S+ S LV+N +L L LSN+ L V LC +++ P C +Q+L + L
Sbjct: 717 SICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWV-LQDLI 775
Query: 1002 LALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVI 1061
+AL GNS LTHL+ S N + V L+ + +R +C+L+ L L KC+L+AA C+ L+ +
Sbjct: 776 IALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFL 834
Query: 1062 SRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCN 1121
+ +H+ L L N L D G+ LC L L RL L C L + C+ LS AL N
Sbjct: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894
Query: 1122 RHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
R LT LNL +N+ +G+ LC A P NLQ + L
Sbjct: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
Score = 60.5 bits (145), Expect = 1e-08
Identities = 49/173 (28%), Positives = 77/173 (44%), Gaps = 2/173 (1%)
Query: 1004 LMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISR 1063
L+ N L L LS + + + VK LC ++ P C +Q L K + L +
Sbjct: 722 LVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTC-KSVTPEWVLQDLIIALQG 780
Query: 1064 SRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRH 1123
+ L L+ + N LG V + + L+ L L L+ C L++ C+ L+L L+ +H
Sbjct: 781 NSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQH 839
Query: 1124 LTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQL 1176
+T L L N G+ LC+A P L+ + LW Q K L + L
Sbjct: 840 VTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 471 bits (1212), Expect = e-132
Identities = 291/907 (32%), Positives = 473/907 (52%), Gaps = 30/907 (3%)
Query: 230 GDTWDYKSHVMTKFAE------EEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVV 283
G T Y++H KF+ ++ FE E L F G +PRTV+
Sbjct: 94 GYTKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQ-EECDHLDRLFAPKEAGKQPRTVI 152
Query: 284 LHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDS 343
+ G GIGK+ L ++++ W+ +++ F Y F+ RE++ +S+ + ISREWPD
Sbjct: 153 IQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDP 212
Query: 344 QAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRKVLLPE 402
AP+TEI+S+PERLLF+ID F++L LN D+ LC D EK+P L+ SLLRK +LPE
Sbjct: 213 AAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPE 272
Query: 403 SFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNR 462
+ L++ ++ V ++L+ +V RG + R+ + + + +
Sbjct: 273 ASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESE 332
Query: 463 ELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNL 522
+L CQ+P + ++C +L+ + G+ +A Q+ T ++++FVF+ TP G
Sbjct: 333 QLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQT 392
Query: 523 EERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTF 582
+ + LK C +A EG+W F DDL G+ ++++ AL ILL E Y F
Sbjct: 393 QHQ--LKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVF 450
Query: 583 FHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGF----HIHSLWMKRFLF 638
H+ +Q+FCAAL+Y+L+ P V+ EL A F H +++ FL
Sbjct: 451 LHVCIQEFCAALFYLLKSHLDHPHPAVRCVQ------ELLVANFEKARRAHWIFLGCFLT 504
Query: 639 GLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKE 698
GL+++ + L+ G + +KQ++ + LG++ N D+L F+CLFE QD
Sbjct: 505 GLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPA 564
Query: 699 FVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPL 758
FV+ A+N QE I N+DL+ S++CL++C LRK+ V+ +F +++ +
Sbjct: 565 FVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSS------ 618
Query: 759 WMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFR 818
D +LI W CS+L T HLR+L + S L+E T C +LRHP+C++Q L
Sbjct: 619 -TSDYSLI--CWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGIN 675
Query: 819 NAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGL 878
N + L+ ++ +L+ L+ T L +D+R C+AL +P ++ L L C L
Sbjct: 676 NVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHL 735
Query: 879 THACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITAT 938
+ ++ +LT + L L+++ N++ D GV L +AL L L+L C ++
Sbjct: 736 SPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQ 794
Query: 939 GCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCG 998
C+ ++ L+ N+S+ +L LS N L +EG+ LC +++ P C L L L +C + AGC
Sbjct: 795 CCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCE 854
Query: 999 FLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLS 1058
LA AL+ N L L + N + D GV+LLC + C L+ L L +C LT+ CC+ L+
Sbjct: 855 DLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLA 914
Query: 1059 CVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLAL 1118
V++ S+ L+ L+LT N L GV LCE L+ L LGL+ + L+
Sbjct: 915 SVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEE 974
Query: 1119 SCNRHLT 1125
N +LT
Sbjct: 975 ERNPNLT 981
Score = 62.8 bits (151), Expect = 2e-09
Identities = 39/108 (36%), Positives = 58/108 (53%), Gaps = 7/108 (6%)
Query: 60 FSSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGA 119
FS +GL W L EL KEEF+ FKE LK+ + + IP E++ A+ E LA LL ++Y
Sbjct: 6 FSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEE 65
Query: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEK 167
AW ++ IF+ M+ + L K + + T T Q +K+K
Sbjct: 66 QQAWNITLRIFQKMDRKDLCMKVMRERTGY-------TKTYQAHAKQK 106
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 463 bits (1192), Expect = e-130
Identities = 314/1045 (30%), Positives = 519/1045 (49%), Gaps = 65/1045 (6%)
Query: 69 LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128
L +L+ + + FK L+ + +P+ + E A+ LA L+ ++ G AWA ++
Sbjct: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
Query: 129 IFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQ 188
IF +N R L EKA+ D +P+ + S V +++++ E +
Sbjct: 74 IFAAINRRDLYEKAKRD-------EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSR 126
Query: 189 EISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDY-KSHVMTKFAEEE 247
M+++ + Q +E A E+ K H + E+E
Sbjct: 127 ISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQE 186
Query: 248 DVRRSFENTAADWPEMQTLAGAFDSDRWGFRP-RTVVLHGKSGIGKSALARRIVLCWAQG 306
+ T + FD D P TVV G +GIGK+ LAR+++L WA G
Sbjct: 187 LLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASG 246
Query: 307 GLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDD 366
LYQ F Y+F++ RE+ + S+ + I PD P+ +I+ +P R+LF++DGFD+
Sbjct: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
Query: 367 L-GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPR 425
L G+ + LC DW + + L+ SL+RK LLPE+ L++T R V EKL+ + PR
Sbjct: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 426 YLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQD 485
++ + G S +R + E Q I N L C +P V ++C L+ Q
Sbjct: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
Query: 486 VVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRR---CLNLEERVVLKRFCRMAVEGVWNR 542
G+S+A ++T T ++ F+ L PRG + C +L C +A +G+WN+
Sbjct: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWG------LCSLAADGIWNQ 480
Query: 543 KSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLE 602
K +F+ DL GL ++++ A MN+ + CE++Y+F H++ Q+F AA+YY+LE +
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
Query: 603 IEPALCP---LYVEKTKRSMELKQAGFHI--HSLWMKRFLFGLVSEDVRRPLEVLLGCPV 657
P L + ++ L+ G + +++ RFLFGLV+++ LE L C +
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
Query: 658 PLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQN 717
++ +LL W+ + + L+ F+CL+E Q+++FV+ A++ F ++ + ++
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
Query: 718 LDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSML 777
+D + SSFC+++C + + + P++E EE+ E
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEE-----------------EEEKEG----- 698
Query: 778 GTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGV-QHLWRIVMAN 836
R LD+ +L + H C + N+ +T + L+ ++ +
Sbjct: 699 ------RHLDMVQCVLPSSS---------HAACSHGLV---NSHLTSSFCRGLFSVLSTS 740
Query: 837 RNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSL 896
++L L+L L + +R+ CE L+HP C + L L CGL+H C IS +L+++ L
Sbjct: 741 QSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL 800
Query: 897 KSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHL 956
L L+ N + D G+ L L+ C L+KL L C +T+ CQ LAS L ++ SLT L
Sbjct: 801 VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRL 860
Query: 957 CLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLS 1016
+ N+LG+ GV +LC + P C+LQ+L L L + C L+ L N LTHL L
Sbjct: 861 YVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLR 920
Query: 1017 MNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNA 1076
N + D G+KLLCE + P C LQ LEL C+LT+ CC LS +++ S+ L+ L L +N
Sbjct: 921 GNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNND 980
Query: 1077 LGDGGVAALCEGLKQKNSVLARLGL 1101
LGD GV CE LKQ++ +L LGL
Sbjct: 981 LGDLGVMMFCEVLKQQSCLLQNLGL 1005
Score = 196 bits (497), Expect = 1e-49
Identities = 127/361 (35%), Positives = 189/361 (52%), Gaps = 12/361 (3%)
Query: 839 LRSLNLGGTH---LKEEDVRMACEALKHPKCLLESLRLDCCG-------LTHACYLKISQ 888
+ SL+LG H +EE+ L +C+L S C LT + +
Sbjct: 676 VESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFS 735
Query: 889 ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948
+L+TS SL L L+ N + D G+ L + L+ C +++L L CG++ C ++ L
Sbjct: 736 VLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLS 795
Query: 949 SNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNS 1008
SN+ L L LS+N+LG+ G+ LLC ++ C+L++L L C L +A C LA L +
Sbjct: 796 SNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSH 855
Query: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068
LT L + N + D+GV +LCE + P C+LQ L LV LT+ CC +LS V+S +++L
Sbjct: 856 SLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLT 915
Query: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLN 1128
L L N LGD G+ LCEGL + L L L C LTS CC LS L+ ++ L L+
Sbjct: 916 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 975
Query: 1129 LVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPR--VVIDGS 1186
L N+ G+M C + LQ +GL + + + + LE +Q KP VV + S
Sbjct: 976 LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPS 1035
Query: 1187 W 1187
W
Sbjct: 1036 W 1036
Score = 129 bits (325), Expect = 1e-29
Identities = 77/242 (31%), Positives = 127/242 (52%), Gaps = 1/242 (0%)
Query: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
C + LW+ L E D +L ++ L +LDL + L + ++ LC L+H C +
Sbjct: 770 CNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNL 829
Query: 813 QTLMFRNAQITPGV-QHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
+ L + +T Q L ++ + +L L +G L + V + CE K+P+C L+ L
Sbjct: 830 KKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKL 889
Query: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
L GLT C +S +L+T+ +L L L GN + D+G+ L + L C LQ L L+
Sbjct: 890 GLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELD 949
Query: 932 DCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCH 991
+C +T+ C L++ L S++SL L L NN LG+ GV + C ++ C LQ L L++ +
Sbjct: 950 NCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMY 1009
Query: 992 LD 993
+
Sbjct: 1010 FN 1011
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 463 bits (1192), Expect = e-130
Identities = 314/1045 (30%), Positives = 519/1045 (49%), Gaps = 65/1045 (6%)
Query: 69 LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128
L +L+ + + FK L+ + +P+ + E A+ LA L+ ++ G AWA ++
Sbjct: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
Query: 129 IFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQ 188
IF +N R L EKA+ D +P+ + S V +++++ E +
Sbjct: 74 IFAAINRRDLYEKAKRD-------EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSR 126
Query: 189 EISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDY-KSHVMTKFAEEE 247
M+++ + Q +E A E+ K H + E+E
Sbjct: 127 ISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQE 186
Query: 248 DVRRSFENTAADWPEMQTLAGAFDSDRWGFRP-RTVVLHGKSGIGKSALARRIVLCWAQG 306
+ T + FD D P TVV G +GIGK+ LAR+++L WA G
Sbjct: 187 LLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASG 246
Query: 307 GLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDD 366
LYQ F Y+F++ RE+ + S+ + I PD P+ +I+ +P R+LF++DGFD+
Sbjct: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
Query: 367 L-GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPR 425
L G+ + LC DW + + L+ SL+RK LLPE+ L++T R V EKL+ + PR
Sbjct: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 426 YLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQD 485
++ + G S +R + E Q I N L C +P V ++C L+ Q
Sbjct: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
Query: 486 VVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRR---CLNLEERVVLKRFCRMAVEGVWNR 542
G+S+A ++T T ++ F+ L PRG + C +L C +A +G+WN+
Sbjct: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWG------LCSLAADGIWNQ 480
Query: 543 KSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLE 602
K +F+ DL GL ++++ A MN+ + CE++Y+F H++ Q+F AA+YY+LE +
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
Query: 603 IEPALCP---LYVEKTKRSMELKQAGFHI--HSLWMKRFLFGLVSEDVRRPLEVLLGCPV 657
P L + ++ L+ G + +++ RFLFGLV+++ LE L C +
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
Query: 658 PLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQN 717
++ +LL W+ + + L+ F+CL+E Q+++FV+ A++ F ++ + ++
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
Query: 718 LDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSML 777
+D + SSFC+++C + + + P++E EE+ E
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEE-----------------EEEKEG----- 698
Query: 778 GTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGV-QHLWRIVMAN 836
R LD+ +L + H C + N+ +T + L+ ++ +
Sbjct: 699 ------RHLDMVQCVLPSSS---------HAACSHGLV---NSHLTSSFCRGLFSVLSTS 740
Query: 837 RNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSL 896
++L L+L L + +R+ CE L+HP C + L L CGL+H C IS +L+++ L
Sbjct: 741 QSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL 800
Query: 897 KSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHL 956
L L+ N + D G+ L L+ C L+KL L C +T+ CQ LAS L ++ SLT L
Sbjct: 801 VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRL 860
Query: 957 CLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLS 1016
+ N+LG+ GV +LC + P C+LQ+L L L + C L+ L N LTHL L
Sbjct: 861 YVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLR 920
Query: 1017 MNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNA 1076
N + D G+KLLCE + P C LQ LEL C+LT+ CC LS +++ S+ L+ L L +N
Sbjct: 921 GNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNND 980
Query: 1077 LGDGGVAALCEGLKQKNSVLARLGL 1101
LGD GV CE LKQ++ +L LGL
Sbjct: 981 LGDLGVMMFCEVLKQQSCLLQNLGL 1005
Score = 196 bits (497), Expect = 1e-49
Identities = 127/361 (35%), Positives = 189/361 (52%), Gaps = 12/361 (3%)
Query: 839 LRSLNLGGTH---LKEEDVRMACEALKHPKCLLESLRLDCCG-------LTHACYLKISQ 888
+ SL+LG H +EE+ L +C+L S C LT + +
Sbjct: 676 VESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFS 735
Query: 889 ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948
+L+TS SL L L+ N + D G+ L + L+ C +++L L CG++ C ++ L
Sbjct: 736 VLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLS 795
Query: 949 SNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNS 1008
SN+ L L LS+N+LG+ G+ LLC ++ C+L++L L C L +A C LA L +
Sbjct: 796 SNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSH 855
Query: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068
LT L + N + D+GV +LCE + P C+LQ L LV LT+ CC +LS V+S +++L
Sbjct: 856 SLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLT 915
Query: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLN 1128
L L N LGD G+ LCEGL + L L L C LTS CC LS L+ ++ L L+
Sbjct: 916 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 975
Query: 1129 LVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPR--VVIDGS 1186
L N+ G+M C + LQ +GL + + + + LE +Q KP VV + S
Sbjct: 976 LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPS 1035
Query: 1187 W 1187
W
Sbjct: 1036 W 1036
Score = 129 bits (325), Expect = 1e-29
Identities = 77/242 (31%), Positives = 127/242 (52%), Gaps = 1/242 (0%)
Query: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
C + LW+ L E D +L ++ L +LDL + L + ++ LC L+H C +
Sbjct: 770 CNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNL 829
Query: 813 QTLMFRNAQITPGV-QHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
+ L + +T Q L ++ + +L L +G L + V + CE K+P+C L+ L
Sbjct: 830 KKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKL 889
Query: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
L GLT C +S +L+T+ +L L L GN + D+G+ L + L C LQ L L+
Sbjct: 890 GLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELD 949
Query: 932 DCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCH 991
+C +T+ C L++ L S++SL L L NN LG+ GV + C ++ C LQ L L++ +
Sbjct: 950 NCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMY 1009
Query: 992 LD 993
+
Sbjct: 1010 FN 1011
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 452 bits (1164), Expect = e-127
Identities = 332/1068 (31%), Positives = 522/1068 (48%), Gaps = 85/1068 (7%)
Query: 63 YGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLA 122
+ LQ L +L ++E FK L+ S IP E++ A+ + L +L + +
Sbjct: 9 FNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWV 68
Query: 123 WATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATA 182
S+ +FE M+ LSE+A+D+++ EA + K GI T
Sbjct: 69 EMASLQVFEKMHRMDLSERAKDEVR-------EAALKSFNKRKPLSLGI---------TR 112
Query: 183 AETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEE--QGHGGDTWDYKSHVM 240
E ++ + +E+ +TE Q + E +G +E +G D + +++
Sbjct: 113 KERPPLDVDEMLER-----FKTEAQAFT---ETKGNVICLGKEVFKGKKPDKDNRCRYIL 164
Query: 241 -TKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPR--------TVVLHGKSGIG 291
TKF R +++ D E+Q +A + PR TVVL+G +G+G
Sbjct: 165 KTKF------REMWKSWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLG 218
Query: 292 KSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIM 351
K+ LA++++L WA+ L F Y F+L RE+ R S E + R+WP+ Q + I+
Sbjct: 219 KTTLAQKLMLDWAEDNLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHIL 277
Query: 352 SRPERLLFIIDGFDDLGSV---LNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVT 408
++ ++LF+IDGFD+LG+ L D +C DW +K+P L+ SLL +V+LP++ L+VT
Sbjct: 278 AQARKILFVIDGFDELGAAPGALIED--ICGDWEKKKPVPVLLGSLLNRVMLPKAALLVT 335
Query: 409 VRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQC 468
R L+ P Y+ V G E R L E Q + + +N L
Sbjct: 336 TRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 395
Query: 469 QVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVL 528
PAV ++C L+LQ GE P T TGL F+ + P+G + R L
Sbjct: 396 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-------QLRGAL 447
Query: 529 KRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQ 588
+ +A +G+W + SV +DL G+ ES+LR +IL D + Y+F HLS Q
Sbjct: 448 RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507
Query: 589 DFCAALYYVLEGLEIEPALCPLY-----------VEKTKRSMELKQAGFHIHSLWMKRFL 637
F AL+Y LE E E + VE+ R+ +L QAG+ +
Sbjct: 508 QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERL-RNPDLIQAGY---------YS 557
Query: 638 FGLVSEDVRRPLEVLLGCPVPLGVKQKLLHW-VSLLGQQPNATTPGDTLDAFHCLFETQD 696
FGL +E + LE GC + +KQ+LL +S G T D + CL+E+Q+
Sbjct: 558 FGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHSTVT---DLQELLGCLYESQE 614
Query: 697 KEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDV-KGIFPRDESAEACPV 755
+E V+ + F+E+ L +N +D++ SSFC++HC L+K+ + V K P + +A
Sbjct: 615 EELVKEVMAQFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDA 673
Query: 756 VPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTL 815
+D + W D CS+ G++ L L + S L+ ++ LC ++ TC +Q +
Sbjct: 674 EVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRV 733
Query: 816 MFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMA-CEALKHPKCLLESLRLD 874
+F+N ++L + ++ + L L G ++D+ A CE L+HP+C L L L
Sbjct: 734 VFKNISPADAHRNLCLALRGHKTVTYLTLQGND--QDDMFPALCEVLRHPECNLRYLGLV 791
Query: 875 CCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCG 934
C T + +S L + SL ++L+ N++ D+G L LR +C LQ+L LE+C
Sbjct: 792 SCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCH 851
Query: 935 ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994
+T C+ LA+ LV +R LTHLCL+ N +GN GV LC +R P C LQ L+L C + +
Sbjct: 852 LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911
Query: 995 AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054
GC L L S L L L +N + G+K LCE +R+P C+L+ L L C + C
Sbjct: 912 DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971
Query: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLK 1102
E L +S ++ L +LDL N LG GV L E L + L L LK
Sbjct: 972 EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLK 1019
Score = 187 bits (474), Expect = 7e-47
Identities = 125/360 (34%), Positives = 180/360 (50%), Gaps = 2/360 (0%)
Query: 829 LWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQ 888
L I +N++L L + + L VR+ CE + C L+ + A + +
Sbjct: 691 LCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADA-HRNLCL 749
Query: 889 ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948
L ++ L+L GN D L + LR +C L+ L L C T L+ AL
Sbjct: 750 ALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
Query: 949 SNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNS 1008
N+SLT + LS+N L +EG LL ++R P C LQRL L CHL A C LA L+ +
Sbjct: 809 VNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSR 868
Query: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068
LTHL L+ NP+ + GVK LCE +R P C LQ L L C +T+ C L+ ++ L
Sbjct: 869 ELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLL 928
Query: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLN 1128
LDL N +G G+ LCE L++ L L L C + CE L ALSCN+ L +L+
Sbjct: 929 CLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLD 988
Query: 1129 LVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWH 1188
L QN G+ L C + L+ + L + ++ KLLEE++ P+++ID H
Sbjct: 989 LGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLIIDTEKH 1048
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 443 bits (1139), Expect = e-124
Identities = 283/861 (32%), Positives = 440/861 (51%), Gaps = 44/861 (5%)
Query: 278 RPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFIS 337
R TVVL G GIGK+ L R+++L WA+G L++ F++VFFL V EM E+S+ E +S
Sbjct: 144 RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLS 203
Query: 338 REWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRK 397
R+WP+S + +I S+PER+LFI+DGF+ L L L DW ++QP ++ SLL+K
Sbjct: 204 RDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQLKADLSDDWRQRQPMPIILSSLLQK 263
Query: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKT-QGLR 456
+LPES L++ + + +K + P+ + + G S E GE K +
Sbjct: 264 KMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFS-ESEKKSYFSYFFGEKSKALKVFN 322
Query: 457 AIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVF------HQL 510
+ +N L C P L+C ++ + GE + +Q T L+A+F+ Q
Sbjct: 323 FVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQS 382
Query: 511 TPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNIL 570
P V R LK C +A EG+W VF DL GL ESE M +L
Sbjct: 383 FPPKV--------NRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLL 434
Query: 571 LPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSME------LKQA 624
C + F HL +Q+FCAA++Y+L+ + +P + + R+ L Q
Sbjct: 435 QRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQV 491
Query: 625 GFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDT 684
G F+FG+ +E++ LE G P+ +KQ++ + L Q
Sbjct: 492 GI---------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAF 542
Query: 685 LDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIF 744
+ F LFETQ+KEFV +N F+EV++ I L+ +SFCL+HC +L +R+ V+ IF
Sbjct: 543 QELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIF 602
Query: 745 PRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAK 804
P D + D W + CSM T+ + + LD+ ++ L + ++ LC
Sbjct: 603 PDDSGC---------ISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKA 653
Query: 805 LRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHP 864
L P CK++ L+F + L++ V+ N +L+ L+L GT L + D+R CE LKHP
Sbjct: 654 LAQPVCKLRKLIFTSVYFGHD-SELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHP 712
Query: 865 KCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCA 924
C +E L L C ++ I+ +L + LK LSL N + D+G+ L +AL+ S CA
Sbjct: 713 MCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCA 772
Query: 925 LQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQR 984
L++L+L C +T+ C S++ L+ ++SL+ L L +N+L + GV LC +++ P CS++
Sbjct: 773 LERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRE 832
Query: 985 LMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
L L C L + C +A L+ N L L L N + D GV+ LC ++ P C L+ L L
Sbjct: 833 LWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGL 892
Query: 1045 VKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKAC 1104
C +T ACC+ ++ + + L+SL+L AL V LCE L + L LGL
Sbjct: 893 QTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKS 952
Query: 1105 GLTSDCCEALSLALSCNRHLT 1125
G + + L HLT
Sbjct: 953 GFDEETQKILMSVEEKIPHLT 973
Score = 210 bits (535), Expect = 6e-54
Identities = 119/362 (32%), Positives = 194/362 (53%), Gaps = 3/362 (0%)
Query: 827 QHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKI 886
+ L + + N+N + L++ T L + + + C+AL P C L L H ++
Sbjct: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDS--EL 677
Query: 887 SQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASA 946
+ + +P LK LSL G ++ + L + L+ C +++LIL C I++ C+ +AS
Sbjct: 678 FKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASV 737
Query: 947 LVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMG 1006
L N L HL L N L +EG+ LLC +++ HC+L+RLML C L + C ++ L+
Sbjct: 738 LACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC 797
Query: 1007 NSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRH 1066
+ L+ L L N +EDNGV LC ++ P C +++L L+ C LT+ C+ ++ V+ +
Sbjct: 798 SKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGK 857
Query: 1067 LKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTS 1126
LK+L L N +GD GV LC L+ + L LGL+ C +T CC+ ++ AL + L S
Sbjct: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917
Query: 1127 LNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVID-G 1185
LNL ++ LC A + P LQ++GL K + + +K+L V+ P + I G
Sbjct: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTISHG 977
Query: 1186 SW 1187
W
Sbjct: 978 PW 979
Score = 67.4 bits (163), Expect = 8e-11
Identities = 35/88 (39%), Positives = 54/88 (61%)
Query: 60 FSSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGA 119
FS +GL W L EL KEEF FKELLK+ + IP E++ A+ E +A LL ++Y
Sbjct: 6 FSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPG 65
Query: 120 SLAWATSISIFENMNLRTLSEKARDDMK 147
AW ++++F +N + L KA+++M+
Sbjct: 66 KQAWEVTLNLFLQINRKDLWTKAQEEMR 93
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 421 bits (1083), Expect = e-117
Identities = 315/1065 (29%), Positives = 507/1065 (47%), Gaps = 105/1065 (9%)
Query: 65 LQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWA 124
LQ L +L+++E ++FK LL E P E+E A+ + LA +L +
Sbjct: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
Query: 125 TSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAE 184
+++I E MNL L + A+ +M ED + D P + A ++DS
Sbjct: 70 ATVNILEEMNLTELCKMAKAEMM----EDGQVQEIDN-------PELGDA-EEDS----- 112
Query: 185 TKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFA 244
E+++ E+EG +ME++ T QG + D + +F
Sbjct: 113 ----ELAKPGEKEGWR----------NSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFI 158
Query: 245 EEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWA 304
+ R + T P TVVLHG +G+GK+ LA++ +L W
Sbjct: 159 PFLNPRTPRKLT----------------------PYTVVLHGPAGVGKTTLAKKCMLDWT 196
Query: 305 QGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGF 364
L + Y F+L +E+ R S E IS++WP+ Q + I+++ +R+LF++DG
Sbjct: 197 DCNLSPTL-RYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGL 255
Query: 365 DDL----GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSE 420
D+L G+++ + +C DW +K+P L+ SLL++ +LP + L+VT R L+
Sbjct: 256 DELKVPPGALIQD---ICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLL 312
Query: 421 VVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVA 480
P Y+ V G E R L E Q + + +N L PAV ++C
Sbjct: 313 AQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTT 372
Query: 481 LQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW 540
L+LQ GE P T TGL F+ + P+G + R L+ +A +G+W
Sbjct: 373 LKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-------QLRGALRTLSLLAAQGLW 424
Query: 541 NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEG 600
+ SVF +DL G+ ES+LR +IL D + Y+F HLS Q F AL+Y LE
Sbjct: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
Query: 601 LE----------IEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLE 650
E I L E+ ++ +L Q G FLFGL +E + LE
Sbjct: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVG---------HFLFGLANEKRAKELE 535
Query: 651 VLLGCPVPLGVKQKLLHWVSLL-GQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQE 709
GC + +KQ+LL + L +P + T D + CL+E+Q++E ++ + F+E
Sbjct: 536 ATFGCRMSPDIKQELLQCKAHLHANKPLSVT--DLKEVLGCLYESQEEELAKVVVAPFKE 593
Query: 710 VWLPINQNLDLIASSFCLQHCPYLRKIRVDV-KGIFPR-------DESAEACP--VVPLW 759
+ + + +++ SF L+HC L+K+ + V KG+F D E C +P W
Sbjct: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNW 653
Query: 760 MRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRN 819
R W DFCS+ ++ +L+ L++ S L++ +++ LC + TC +Q + +N
Sbjct: 654 ARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKN 713
Query: 820 AQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMA--CEALKHPKCLLESLRLDCCG 877
+ + + L L L G H++ E M C+ L++ KC L+ LRL
Sbjct: 714 VTPDTAYRDFCLAFIGKKTLTHLTLAG-HIEWERTMMLMLCDLLRNHKCNLQYLRLGGHC 772
Query: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
T + + +L + SLK L L+ N + D+G M L + + LQ L LE+C +T
Sbjct: 773 ATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTE 832
Query: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
C+ LA+ LV ++ LTHLCL+ N +G+ GV LC + P C LQ L+L QC + GC
Sbjct: 833 ASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGC 892
Query: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESL 1057
+L+ AL LT+L LS+N + G+ +LC+ + P+C+L+ L L C L C+ L
Sbjct: 893 RYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHL 951
Query: 1058 SCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLK 1102
+ ++ L++LDL N L G+ L L+Q+ L L LK
Sbjct: 952 GSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLK 996
Score = 124 bits (312), Expect = 4e-28
Identities = 101/296 (34%), Positives = 141/296 (47%), Gaps = 18/296 (6%)
Query: 868 LESLRL--DCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCAL 925
L SLRL D C L +++ +LK L + + ++D V L D + S C L
Sbjct: 658 LRSLRLWTDFCSL-----------FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHL 706
Query: 926 QKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNL-LCRSMRLPHCSLQR 984
QK+ +++ T + A + ++LTHL L+ + + L LC +R C+LQ
Sbjct: 707 QKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQY 765
Query: 985 LMLN-QCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLE 1043
L L C F + L N L HL LS N + D G LL + M P LQ L
Sbjct: 766 LRLGGHCATPEQWAEFFYV-LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLS 824
Query: 1044 LVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKA 1103
L C LT A C+ L+ V+ S+ L L L N +GD GV LCEGL + L L L+
Sbjct: 825 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 884
Query: 1104 CGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLW 1159
C +T C LS AL LT+L+L N + +G+ LC A P NL+ + LW
Sbjct: 885 CSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLW 939
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 417 bits (1072), Expect = e-116
Identities = 279/908 (30%), Positives = 453/908 (49%), Gaps = 39/908 (4%)
Query: 205 EEQEISQAMEQEGATAAETE---EQGHGGDTWDYKSHVMTKFAEEEDV------RRSFEN 255
E I +E E ET+ E+G G YKS+VM KF D+ +R F
Sbjct: 120 EINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFPIWDITTWPGNQRDFFY 179
Query: 256 TAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSY 315
E G +P+TV + G GIGK+ LA++++ WA+ Y
Sbjct: 180 QGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWC 239
Query: 316 VFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDT 375
F+ +E+ + + S +E I ++WP SQ V++IMS+P++LL ++DGF++L S L +
Sbjct: 240 AFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRL 299
Query: 376 K-LCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISG 434
+ L +DW +K P L+ SLL K +LPE+ L++ +R + K + P + + G +
Sbjct: 300 EDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNT 359
Query: 435 EQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPF 494
++I + Q L M N L C+VP V ++C L+ Q G
Sbjct: 360 MEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGN----- 414
Query: 495 NQTLTGLHAAFVFHQLTPRGVVRRCLNLEERV---VLKRFCRMAVEGVWNRKSVFDGDDL 551
N T + +A VF + R N ++ L+ C +A + +W+RK V +DL
Sbjct: 415 NLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDL 474
Query: 552 MVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVL---EGLEIEPALC 608
L ++ + A M+IL + E++Y F ++ Q+F AAL+YVL + L+ L
Sbjct: 475 EEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLS 534
Query: 609 PLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHW 668
+ +++ S G + M FLFG ++E +E C V G K+KLL
Sbjct: 535 HVNIQRLIASPR----GSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKV 590
Query: 669 VSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQ 728
+ LL + + F+CL E +++ FV ALN + +V L I N ++ S+FCL+
Sbjct: 591 IPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLK 650
Query: 729 HCPYLRKIRVDVK----GIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLR 784
C YL ++ + V ++ S+ P + + W+D CS+ T+ L
Sbjct: 651 RCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAP----ESNGLHRWWQDLCSVFATNDKLE 706
Query: 785 QLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNL 844
L + +S+L +K L A LRHP CK+Q L+ R T Q L ++ N++LR L +
Sbjct: 707 VLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEI 766
Query: 845 GGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGN 904
++ + V++ C L+ P+C L+ LRL+ C T + + L + LK+L L N
Sbjct: 767 QHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKN 826
Query: 905 KVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLG 964
+ + G LS A L++L +E+C +T C+SLAS L ++ LTHL L+ N+L
Sbjct: 827 SLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALK 880
Query: 965 NEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNG 1024
+EG + ++ C LQRL+L +C L C + AL N L L LS N ++D+G
Sbjct: 881 DEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDG 940
Query: 1025 VKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAA 1084
V LLCE ++ P C LQ LEL C T+ CC++++ ++ +++HL+ LDL+ NA+G G+
Sbjct: 941 VILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILT 1000
Query: 1085 LCEGLKQK 1092
LCE +
Sbjct: 1001 LCEAFSSQ 1008
Score = 167 bits (422), Expect = 7e-41
Identities = 114/330 (34%), Positives = 161/330 (48%), Gaps = 7/330 (2%)
Query: 827 QHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKI 886
Q L + N L L + + L ++ AL+HP+C L+ L L T I
Sbjct: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752
Query: 887 SQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASA 946
+LT + L+ L + +V + V L LR +C LQ L LEDC T L +
Sbjct: 753 G-VLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
Query: 947 LVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMG 1006
L N L L L NSL N C + L L+RL + C+L C LA L
Sbjct: 812 LQGNGHLKTLILRKNSLEN------CGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQ 865
Query: 1007 NSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRH 1066
+ LTHLSL+ N ++D G K + + C LQ L L KC LT CC+ + + +++
Sbjct: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925
Query: 1067 LKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTS 1126
LKSLDL+ N+L D GV LCE LK + L L L+ C TS CC+A++ L N+HL
Sbjct: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRH 985
Query: 1127 LNLVQNNFSPKGMMKLCSAFACPTSNLQII 1156
L+L +N G++ LC AF+ ++I
Sbjct: 986 LDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015
Score = 131 bits (329), Expect = 4e-30
Identities = 91/279 (32%), Positives = 132/279 (47%), Gaps = 7/279 (2%)
Query: 880 HACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATG 939
H + + + T+ L+ L++ + + + L+ ALR QC LQKL+L T
Sbjct: 689 HRWWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN 748
Query: 940 CQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGF 999
Q L L N+ L +L + + + ++ V LLCR +R P C LQ L L C
Sbjct: 749 -QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTD 807
Query: 1000 LALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSC 1059
L L GN L L L N +E+ G L L+ L + C+LT CESL+
Sbjct: 808 LGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQ------LERLSIENCNLTQLTCESLAS 861
Query: 1060 VISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALS 1119
+ +S+ L L L +NAL D G + L L RL L+ C LT +CC+ + AL
Sbjct: 862 CLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALC 921
Query: 1120 CNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
N+ L SL+L N+ G++ LC A P LQI+ L
Sbjct: 922 KNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 414 bits (1063), Expect = e-115
Identities = 285/988 (28%), Positives = 487/988 (49%), Gaps = 65/988 (6%)
Query: 69 LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128
L +L+ + + FK L+ + +P+ + E A+ LA L+ ++ G AWA ++
Sbjct: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
Query: 129 IFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQ 188
IF +N R L EKA+ D +P+ + S V +++++ E +
Sbjct: 74 IFAAINRRDLYEKAKRD-------EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSR 126
Query: 189 EISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDY-KSHVMTKFAEEE 247
M+++ + Q +E A E+ K H + E+E
Sbjct: 127 ISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQE 186
Query: 248 DVRRSFENTAADWPEMQTLAGAFDSDRWGFRP-RTVVLHGKSGIGKSALARRIVLCWAQG 306
+ T + FD D P TVV G +GIGK+ LAR+++L WA G
Sbjct: 187 LLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASG 246
Query: 307 GLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDD 366
LYQ F Y+F++ RE+ + S+ + I PD P+ +I+ +P R+LF++DGFD+
Sbjct: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
Query: 367 L-GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPR 425
L G+ + LC DW + + L+ SL+RK LLPE+ L++T R V EKL+ + PR
Sbjct: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 426 YLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQD 485
++ + G S +R + E Q I N L C +P V ++C L+ Q
Sbjct: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
Query: 486 VVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRR---CLNLEERVVLKRFCRMAVEGVWNR 542
G+S+A ++T T ++ F+ L PRG + C +L C +A +G+WN+
Sbjct: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWG------LCSLAADGIWNQ 480
Query: 543 KSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLE 602
K +F+ DL GL ++++ A MN+ + CE++Y+F H++ Q+F AA+YY+LE +
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
Query: 603 IEPALCP---LYVEKTKRSMELKQAGFHI--HSLWMKRFLFGLVSEDVRRPLEVLLGCPV 657
P L + ++ L+ G + +++ RFLFGLV+++ LE L C +
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
Query: 658 PLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQN 717
++ +LL W+ + + L+ F+CL+E Q+++FV+ A++ F ++ + ++
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
Query: 718 LDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSML 777
+D + SSFC+++C + + + P++E EE+ E
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEE-----------------EEEKEG----- 698
Query: 778 GTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGV-QHLWRIVMAN 836
R LD+ +L + H C + N+ +T + L+ ++ +
Sbjct: 699 ------RHLDMVQCVLPSSS---------HAACSHGLV---NSHLTSSFCRGLFSVLSTS 740
Query: 837 RNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSL 896
++L L+L L + +R+ CE L+HP C + L L CGL+H C IS +L+++ L
Sbjct: 741 QSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL 800
Query: 897 KSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHL 956
L L+ N + D G+ L L+ C L+KL L + G+T+ C +L+S L +N++LTHL
Sbjct: 801 VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHL 860
Query: 957 CLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLS 1016
L N+LG++G+ LLC + P C LQ L L+ C+L + C L+ L + L LSL
Sbjct: 861 YLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLG 920
Query: 1017 MNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
N + D GV + CEV+++ SC LQ+L L
Sbjct: 921 NNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
Score = 169 bits (428), Expect = 1e-41
Identities = 97/255 (38%), Positives = 146/255 (57%), Gaps = 2/255 (0%)
Query: 935 ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994
+T++ C+ L S L +++SLT L LS+NSLG+ G+ +LC +++ P C+++RL L +C L
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 995 AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054
C ++L L N L L LS N + D G++LLC ++ C+L+ L LV LT+ CC
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCC 844
Query: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEAL 1114
+LS V+S +++L L L N LGD G+ LCEGL + L L L C LTS CC L
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 904
Query: 1115 SLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEV 1174
S L+ ++ L L+L N+ G+M C + LQ +GL + + + + LE +
Sbjct: 905 STLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETL 964
Query: 1175 QLLKPR--VVIDGSW 1187
Q KP VV + SW
Sbjct: 965 QEEKPELTVVFEPSW 979
Score = 161 bits (407), Expect = 4e-39
Identities = 101/273 (36%), Positives = 149/273 (54%), Gaps = 10/273 (3%)
Query: 839 LRSLNLGGTH---LKEEDVRMACEALKHPKCLLESLRLDCCG-------LTHACYLKISQ 888
+ SL+LG H +EE+ L +C+L S C LT + +
Sbjct: 676 VESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFS 735
Query: 889 ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948
+L+TS SL L L+ N + D G+ L + L+ C +++L L CG++ C ++ L
Sbjct: 736 VLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLS 795
Query: 949 SNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNS 1008
SN+ L L LS+N+LG+ G+ LLC ++ C+L++L L L + C L+ L N
Sbjct: 796 SNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQ 855
Query: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068
LTHL L N + D G+KLLCE + P C LQ LEL C+LT+ CC LS +++ S+ L+
Sbjct: 856 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 915
Query: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGL 1101
L L +N LGD GV CE LKQ++ +L LGL
Sbjct: 916 KLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
Score = 127 bits (320), Expect = 5e-29
Identities = 73/180 (40%), Positives = 102/180 (56%), Gaps = 1/180 (0%)
Query: 979 HCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCH 1038
H + ++N HL ++ C L L + LT L LS N + D G+++LCE ++ P C+
Sbjct: 713 HAACSHGLVNS-HLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCN 771
Query: 1039 LQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLAR 1098
++ L L +C L+ CC +S V+S ++ L LDL+DNALGD G+ LC GLK L +
Sbjct: 772 IRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKK 831
Query: 1099 LGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
L L GLTS CC ALS LS N++LT L L N KG+ LC P LQ++ L
Sbjct: 832 LWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 891
Score = 105 bits (263), Expect = 2e-22
Identities = 62/181 (34%), Positives = 94/181 (51%), Gaps = 1/181 (0%)
Query: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
C + LW+ L E D +L ++ L +LDL + L + ++ LC L+H C +
Sbjct: 770 CNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNL 829
Query: 813 QTLMFRNAQITP-GVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
+ L N+ +T L ++ N+NL L L G L ++ +++ CE L HP C L+ L
Sbjct: 830 KKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVL 889
Query: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
LD C LT C +S +LT+S SL+ LSL N + D GVM + L+ C LQ L L
Sbjct: 890 ELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLS 949
Query: 932 D 932
+
Sbjct: 950 E 950
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 409 bits (1051), Expect = e-114
Identities = 289/987 (29%), Positives = 482/987 (48%), Gaps = 63/987 (6%)
Query: 69 LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128
L +L+ + + FK L+ + +P+ + E A+ LA L+ ++ G AWA ++
Sbjct: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
Query: 129 IFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQ 188
IF +N R L EKA+ D +P+ + S V +++++ E +
Sbjct: 74 IFAAINRRDLYEKAKRD-------EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSR 126
Query: 189 EISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDY-KSHVMTKFAEEE 247
M+++ + Q +E A E+ K H + E+E
Sbjct: 127 ISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQE 186
Query: 248 DVRRSFENTAADWPEMQTLAGAFDSDRWGFRP-RTVVLHGKSGIGKSALARRIVLCWAQG 306
+ T + FD D P TVV G +GIGK+ LAR+++L WA G
Sbjct: 187 LLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASG 246
Query: 307 GLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDD 366
LYQ F Y+F++ RE+ + S+ + I PD P+ +I+ +P R+LF++DGFD+
Sbjct: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
Query: 367 L-GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPR 425
L G+ + LC DW + + L+ SL+RK LLPE+ L++T R V EKL+ + PR
Sbjct: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 426 YLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQD 485
++ + G S +R + E Q I N L C +P V ++C L+ Q
Sbjct: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
Query: 486 VVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRR---CLNLEERVVLKRFCRMAVEGVWNR 542
G+S+A ++T T ++ F+ L PRG + C +L C +A +G+WN+
Sbjct: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWG------LCSLAADGIWNQ 480
Query: 543 KSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLE 602
K +F+ DL GL ++++ A MN+ + CE++Y+F H++ Q+F AA+YY+LE +
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
Query: 603 IEPALCP---LYVEKTKRSMELKQAGFHI--HSLWMKRFLFGLVSEDVRRPLEVLLGCPV 657
P L + ++ L+ G + +++ RFLFGLV+++ LE L C +
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
Query: 658 PLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQN 717
++ +LL W+ + + L+ F+CL+E Q+++FV+ A++ F ++ + ++
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
Query: 718 LDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSML 777
+D + SSFC+++C + + + P++E EE+ E
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEE-----------------EEEKE------ 697
Query: 778 GTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANR 837
G H + Q L SS + L H C +L ++ +N+
Sbjct: 698 GRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL----------------VLSSNQ 741
Query: 838 NLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLK 897
L L+L L + +R+ C LKH C L+ L L C LT AC ++ +L+TS SL
Sbjct: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801
Query: 898 SLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLC 957
L + N + D GV L + + QC LQKL L + G+T+ C +L+S L +N++LTHL
Sbjct: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
Query: 958 LSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSM 1017
L N+LG++G+ LLC + P C LQ L L+ C+L + C L+ L + L LSL
Sbjct: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 921
Query: 1018 NPVEDNGVKLLCEVMREPSCHLQDLEL 1044
N + D GV + CEV+++ SC LQ+L L
Sbjct: 922 NDLGDLGVMMFCEVLKQQSCLLQNLGL 948
Score = 179 bits (455), Expect = 1e-44
Identities = 109/273 (39%), Positives = 152/273 (55%), Gaps = 10/273 (3%)
Query: 839 LRSLNLGGTH---LKEEDVRMACEALKHPKCLLESLR-------LDCCGLTHACYLKISQ 888
+ SL+LG H +EE+ L +C+L S L CGL+H C IS
Sbjct: 676 VESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL 735
Query: 889 ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948
+L+++ L L L+ N + D G+ L L+ C L+KL L C +T+ CQ LAS L
Sbjct: 736 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 795
Query: 949 SNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNS 1008
++ SLT L + N+LG+ GV +LC + P C+LQ+L L L + C L+ L N
Sbjct: 796 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 855
Query: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068
LTHL L N + D G+KLLCE + P C LQ LEL C+LT+ CC LS +++ S+ L+
Sbjct: 856 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 915
Query: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGL 1101
L L +N LGD GV CE LKQ++ +L LGL
Sbjct: 916 KLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
Score = 167 bits (422), Expect = 7e-41
Identities = 98/257 (38%), Positives = 142/257 (55%), Gaps = 2/257 (0%)
Query: 933 CGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHL 992
CG++ C ++ L SN+ L L LS+N+LG+ G+ LLC ++ C+L++L L C L
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
Query: 993 DTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAA 1052
+A C LA L + LT L + N + D+GV +LCE + P C+LQ L LV LT+
Sbjct: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
Query: 1053 CCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCE 1112
CC +LS V+S +++L L L N LGD G+ LCEGL + L L L C LTS CC
Sbjct: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902
Query: 1113 ALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLE 1172
LS L+ ++ L L+L N+ G+M C + LQ +GL + + + + LE
Sbjct: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALE 962
Query: 1173 EVQLLKPR--VVIDGSW 1187
+Q KP VV + SW
Sbjct: 963 TLQEEKPELTVVFEPSW 979
Score = 132 bits (331), Expect = 3e-30
Identities = 75/172 (43%), Positives = 97/172 (56%)
Query: 987 LNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVK 1046
L +C L C ++L L N L L LS N + D G++LLC ++ C+L+ L LV
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
Query: 1047 CHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGL 1106
C LT+ACC+ L+ V+S S L L + +NALGD GVA LCE K L +LGL GL
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
Query: 1107 TSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
TS CC ALS LS N++LT L L N KG+ LC P LQ++ L
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 891
Score = 109 bits (273), Expect = 1e-23
Identities = 63/181 (34%), Positives = 94/181 (51%), Gaps = 1/181 (0%)
Query: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
C + LW+ L +D S+L T L +L +G + L + + LC K ++P C +
Sbjct: 770 CNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNL 829
Query: 813 QTLMFRNAQITP-GVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
Q L N+ +T L ++ N+NL L L G L ++ +++ CE L HP C L+ L
Sbjct: 830 QKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVL 889
Query: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
LD C LT C +S +LT+S SL+ LSL N + D GVM + L+ C LQ L L
Sbjct: 890 ELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLS 949
Query: 932 D 932
+
Sbjct: 950 E 950
Score = 40.4 bits (93), Expect = 0.010
Identities = 22/59 (37%), Positives = 30/59 (50%)
Query: 1100 GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
GL CGL+ +CC +SL LS N+ L L+L N G+ LC NL+ + L
Sbjct: 719 GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 777
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform 1
[Homo sapiens]
Length = 1009
Score = 397 bits (1019), Expect = e-110
Identities = 307/1056 (29%), Positives = 501/1056 (47%), Gaps = 115/1056 (10%)
Query: 65 LQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWA 124
LQ L +L+++E ++FK LL E P E+E A+ + LA +L +
Sbjct: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
Query: 125 TSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAE 184
+++I E MNL L + A+ +M ED + D P + A ++DS
Sbjct: 70 ATVNILEEMNLTELCKMAKAEMM----EDGQVQEIDN-------PELGDA-EEDS----- 112
Query: 185 TKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFA 244
E+++ E+EG +ME++ T QG + D + +F
Sbjct: 113 ----ELAKPGEKEGWR----------NSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFI 158
Query: 245 EEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWA 304
+ R + T P TVVLHG +G+GK+ LA++ +L W
Sbjct: 159 PFLNPRTPRKLT----------------------PYTVVLHGPAGVGKTTLAKKCMLDWT 196
Query: 305 QGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGF 364
L + Y F+L +E+ R S E IS++WP+ Q + I+++ +R+LF++DG
Sbjct: 197 DCNLSPTL-RYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGL 255
Query: 365 DDL----GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSE 420
D+L G+++ + +C DW +K+P L+ SLL++ +LP + L+VT R L+
Sbjct: 256 DELKVPPGALIQD---ICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLL 312
Query: 421 VVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVA 480
P Y+ V G E R L E Q + + +N L PAV ++C
Sbjct: 313 AQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTT 372
Query: 481 LQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW 540
L+LQ GE P T TGL F+ + P+G + R L+ +A +G+W
Sbjct: 373 LKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-------QLRGALRTLSLLAAQGLW 424
Query: 541 NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEG 600
+ SVF +DL G+ ES+LR +IL D + Y+F HLS Q F AL+Y LE
Sbjct: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
Query: 601 LE----------IEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLE 650
E I L E+ ++ +L Q G FLFGL +E + LE
Sbjct: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVG---------HFLFGLANEKRAKELE 535
Query: 651 VLLGCPVPLGVKQKLLHWVSLL-GQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQE 709
GC + +KQ+LL + L +P + T D + CL+E+Q++E ++ + F+E
Sbjct: 536 ATFGCRMSPDIKQELLQCKAHLHANKPLSVT--DLKEVLGCLYESQEEELAKVVVAPFKE 593
Query: 710 VWLPINQNLDLIASSFCLQHCPYLRKIRVDV-KGIFPRDESAEACPVVPLWMRDKTLIEE 768
+ + + +++ SF L+HC L+K+ + V KG+F + +M + IE
Sbjct: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLEN-----------YMDFELDIEF 642
Query: 769 QWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQH 828
+ ++ +L+ L++ S L++ +++ LC + TC +Q + +N +
Sbjct: 643 E--------SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRD 694
Query: 829 LWRIVMANRNLRSLNLGGTHLKEEDVRMA--CEALKHPKCLLESLRLDCCGLTHACYLKI 886
+ + L L L G H++ E M C+ L++ KC L+ LRL T + +
Sbjct: 695 FCLAFIGKKTLTHLTLAG-HIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEF 753
Query: 887 SQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASA 946
+L + SLK L L+ N + D+G M L + + LQ L LE+C +T C+ LA+
Sbjct: 754 FYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAV 813
Query: 947 LVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMG 1006
LV ++ LTHLCL+ N +G+ GV LC + P C LQ L+L QC + GC +L+ AL
Sbjct: 814 LVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQE 873
Query: 1007 NSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRH 1066
LT+L LS+N + G+ +LC+ + P+C+L+ L L C L C+ L + ++
Sbjct: 874 ACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 932
Query: 1067 LKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLK 1102
L++LDL N L G+ L L+Q+ L L LK
Sbjct: 933 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLK 968
Score = 173 bits (438), Expect = 1e-42
Identities = 121/351 (34%), Positives = 178/351 (50%), Gaps = 3/351 (0%)
Query: 835 ANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSP 894
+N NL+ L + + L + VR+ C+ + C L+ + + Y
Sbjct: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGKK 703
Query: 895 SLKSLSLAGNKVTDQGVM-PLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSL 953
+L L+LAG+ ++ +M L D LR +C LQ L L T L +N+SL
Sbjct: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
Query: 954 THLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHL 1013
HL LS N L +EG LL ++M P LQ L L C L A C LA L+ + LTHL
Sbjct: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHL 823
Query: 1014 SLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLT 1073
L+ NP+ D GVK LCE + P C LQ L L +C +T C LS + + L +LDL+
Sbjct: 824 CLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS 883
Query: 1074 DNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNN 1133
N + G + LC+ L+ N L L L +C L C+ L AL N+ L +L+L QN+
Sbjct: 884 INQIARG-LWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNH 942
Query: 1134 FSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVID 1184
G++KL T +L+I+ L ++ ++I+KLLEEV+ P++ ID
Sbjct: 943 LWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTID 993
Score = 123 bits (309), Expect = 9e-28
Identities = 93/271 (34%), Positives = 133/271 (49%), Gaps = 5/271 (1%)
Query: 891 TTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSN 950
+++ +LK L + + ++D V L D + S C LQK+ +++ T + A +
Sbjct: 644 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGK 702
Query: 951 RSLTHLCLSNNSLGNEGVNL-LCRSMRLPHCSLQRLMLN-QCHLDTAGCGFLALALMGNS 1008
++LTHL L+ + + L LC +R C+LQ L L C F + L N
Sbjct: 703 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV-LKANQ 761
Query: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068
L HL LS N + D G LL + M P LQ L L C LT A C+ L+ V+ S+ L
Sbjct: 762 SLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLT 821
Query: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLN 1128
L L N +GD GV LCEGL + L L L+ C +T C LS AL LT+L+
Sbjct: 822 HLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLD 881
Query: 1129 LVQNNFSPKGMMKLCSAFACPTSNLQIIGLW 1159
L N + +G+ LC A P NL+ + LW
Sbjct: 882 LSINQIA-RGLWILCQALENPNCNLKHLRLW 911
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform 2
[Homo sapiens]
Length = 980
Score = 396 bits (1018), Expect = e-110
Identities = 297/1007 (29%), Positives = 480/1007 (47%), Gaps = 105/1007 (10%)
Query: 65 LQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWA 124
LQ L +L+++E ++FK LL E P E+E A+ + LA +L +
Sbjct: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
Query: 125 TSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAE 184
+++I E MNL L + A+ +M ED + D P + A ++DS
Sbjct: 70 ATVNILEEMNLTELCKMAKAEMM----EDGQVQEIDN-------PELGDA-EEDS----- 112
Query: 185 TKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFA 244
E+++ E+EG +ME++ T QG + D + +F
Sbjct: 113 ----ELAKPGEKEGWR----------NSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFI 158
Query: 245 EEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWA 304
+ R + T P TVVLHG +G+GK+ LA++ +L W
Sbjct: 159 PFLNPRTPRKLT----------------------PYTVVLHGPAGVGKTTLAKKCMLDWT 196
Query: 305 QGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGF 364
L + Y F+L +E+ R S E IS++WP+ Q + I+++ +R+LF++DG
Sbjct: 197 DCNLSPTL-RYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGL 255
Query: 365 DDL----GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSE 420
D+L G+++ + +C DW +K+P L+ SLL++ +LP + L+VT R L+
Sbjct: 256 DELKVPPGALIQD---ICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLL 312
Query: 421 VVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVA 480
P Y+ V G E R L E Q + + +N L PAV ++C
Sbjct: 313 AQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTT 372
Query: 481 LQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW 540
L+LQ GE P T TGL F+ + P+G + R L+ +A +G+W
Sbjct: 373 LKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-------QLRGALRTLSLLAAQGLW 424
Query: 541 NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEG 600
+ SVF +DL G+ ES+LR +IL D + Y+F HLS Q F AL+Y LE
Sbjct: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
Query: 601 LE----------IEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLE 650
E I L E+ ++ +L Q G FLFGL +E + LE
Sbjct: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVG---------HFLFGLANEKRAKELE 535
Query: 651 VLLGCPVPLGVKQKLLHWVSLL-GQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQE 709
GC + +KQ+LL + L +P + T D + CL+E+Q++E ++ + F+E
Sbjct: 536 ATFGCRMSPDIKQELLQCKAHLHANKPLSVT--DLKEVLGCLYESQEEELAKVVVAPFKE 593
Query: 710 VWLPINQNLDLIASSFCLQHCPYLRKIRVDV-KGIFPR-------DESAEACP--VVPLW 759
+ + + +++ SF L+HC L+K+ + V KG+F D E C +P W
Sbjct: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNW 653
Query: 760 MRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRN 819
R W DFCS+ ++ +L+ L++ S L++ +++ LC + TC +Q + +N
Sbjct: 654 ARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKN 713
Query: 820 AQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMA--CEALKHPKCLLESLRLDCCG 877
+ + + L L L G H++ E M C+ L++ KC L+ LRL
Sbjct: 714 VTPDTAYRDFCLAFIGKKTLTHLTLAG-HIEWERTMMLMLCDLLRNHKCNLQYLRLGGHC 772
Query: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
T + + +L + SLK L L+ N + D+G M L + + LQ L LE+C +T
Sbjct: 773 ATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTE 832
Query: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
C+ LA+ LV ++ LTHLCL+ N +G+ GV LC + P C LQ L+L QC + GC
Sbjct: 833 ASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGC 892
Query: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
+L+ AL LT+L LS+N + G+ +LC+ + P+C+L+ L L
Sbjct: 893 RYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
Score = 139 bits (349), Expect = 2e-32
Identities = 110/321 (34%), Positives = 158/321 (49%), Gaps = 18/321 (5%)
Query: 868 LESLRL--DCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCAL 925
L SLRL D C L +++ +LK L + + ++D V L D + S C L
Sbjct: 658 LRSLRLWTDFCSL-----------FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHL 706
Query: 926 QKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNL-LCRSMRLPHCSLQR 984
QK+ +++ T + A + ++LTHL L+ + + L LC +R C+LQ
Sbjct: 707 QKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQY 765
Query: 985 LMLN-QCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLE 1043
L L C F + L N L HL LS N + D G LL + M P LQ L
Sbjct: 766 LRLGGHCATPEQWAEFFYV-LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLS 824
Query: 1044 LVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKA 1103
L C LT A C+ L+ V+ S+ L L L N +GD GV LCEGL + L L L+
Sbjct: 825 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 884
Query: 1104 CGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQY 1163
C +T C LS AL LT+L+L N + +G+ LC A P NL+ + L ++
Sbjct: 885 CSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYET 943
Query: 1164 PVQIRKLLEEVQLLKPRVVID 1184
++I+KLLEEV+ P++ ID
Sbjct: 944 NLEIKKLLEEVKEKNPKLTID 964
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 370 bits (949), Expect = e-102
Identities = 245/838 (29%), Positives = 424/838 (50%), Gaps = 25/838 (2%)
Query: 282 VVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWP 341
V L G+ GK+ + VL W +G ++Q M SYV L E+ + SS+ E I+++WP
Sbjct: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208
Query: 342 DSQAPVTEIMSRPERLLFIIDGFDDLGSVLN-NDTKLCKDWAEKQPPFTLIRSLLRKVLL 400
D QAP+ +I+S P++LLFI++ D++ LN N++ LC + +K P L+ SLL++ +
Sbjct: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268
Query: 401 PESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMN 460
P + +++ R +K+ + +S +R + + Q+ +++
Sbjct: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKR-EIYFNSFFKDRQRASAALQLVH 327
Query: 461 NRELL-DQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRC 519
E+L C+V + + C L+ Q G QT T LHA F+ LT +
Sbjct: 328 EDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTA- 386
Query: 520 LNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEY 579
N +LKR C +A G++ F G+DL G E+++ L NILLP + ++
Sbjct: 387 -NQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDR 445
Query: 580 YTFFHLSLQDFCAALYYVLEGLE-IEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLF 638
Y F HL++Q+FC A+ +++ + P+ Y EK ++ + Q + F+F
Sbjct: 446 YKFIHLNVQEFCTAIAFLMAVPNYLIPSGSREYKEKREQYSDFNQ---------VFTFIF 496
Query: 639 GLVSEDVRRPLEVLLGCPVPL--GVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQD 696
GL++ + R+ LE G +P+ K + ++ L + P T + F+CL+E ++
Sbjct: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLT--HHMPLFYCLYENRE 554
Query: 697 KEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVV 756
+EFV+ +++ EV + + + D++ S +CL +C +LR +++ V+ IF E +
Sbjct: 555 EEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPL----IR 610
Query: 757 PLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLM 816
P + K+L+ W + CS+ T LR+L + + L + + L L H +CK++TL
Sbjct: 611 PTASQMKSLV--YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLK 668
Query: 817 FRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCC 876
G + L + + NR+L L++ T + + + L P C + L L C
Sbjct: 669 LSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKC 728
Query: 877 GLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGIT 936
L + +I+ +L + SL+ L+L+ N + G+ L DAL C L L+L C +T
Sbjct: 729 DLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLT 788
Query: 937 ATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAG 996
C +L L+ + +L L L N L N GV + + P C L+ L L+ C +
Sbjct: 789 ENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDI 848
Query: 997 CGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCES 1056
C ++A+ + N L L + N +ED G++LLC +R P+C L ++ L +C LT+ACC S
Sbjct: 849 CQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRS 908
Query: 1057 LSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEAL 1114
L+ V++ ++ L+ L+L N LG+ GVA L E L + VL +GL GL + + L
Sbjct: 909 LASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLL 966
Score = 39.3 bits (90), Expect = 0.023
Identities = 26/81 (32%), Positives = 36/81 (44%), Gaps = 3/81 (3%)
Query: 61 SSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGAS 120
+ + L W L L +EFQ+FK+ L +K + +PQF + E LA +L Y
Sbjct: 7 TDFDLLWYLENLSDKEFQSFKKYLARKILD---FKLPQFPLIQMTKEELANVLPISYEGQ 63
Query: 121 LAWATSISIFENMNLRTLSEK 141
W SIF M L K
Sbjct: 64 YIWNMLFSIFSMMRKEDLCRK 84
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 363 bits (932), Expect = e-100
Identities = 253/893 (28%), Positives = 434/893 (48%), Gaps = 42/893 (4%)
Query: 69 LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128
L +L+ + + FK L+ + +P+ + E A+ LA L+ ++ G AWA ++
Sbjct: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
Query: 129 IFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQ 188
IF +N R L EKA+ D +P+ + S V +++++ E +
Sbjct: 74 IFAAINRRDLYEKAKRD-------EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSR 126
Query: 189 EISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDY-KSHVMTKFAEEE 247
M+++ + Q +E A E+ K H + E+E
Sbjct: 127 ISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQE 186
Query: 248 DVRRSFENTAADWPEMQTLAGAFDSDRWGFRP-RTVVLHGKSGIGKSALARRIVLCWAQG 306
+ T + FD D P TVV G +GIGK+ LAR+++L WA G
Sbjct: 187 LLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASG 246
Query: 307 GLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDD 366
LYQ F Y+F++ RE+ + S+ + I PD P+ +I+ +P R+LF++DGFD+
Sbjct: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
Query: 367 L-GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPR 425
L G+ + LC DW + + L+ SL+RK LLPE+ L++T R V EKL+ + PR
Sbjct: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 426 YLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQD 485
++ + G S +R + E Q I N L C +P V ++C L+ Q
Sbjct: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
Query: 486 VVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRR---CLNLEERVVLKRFCRMAVEGVWNR 542
G+S+A ++T T ++ F+ L PRG + C + L C +A +G+WN+
Sbjct: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAH------LWGLCSLAADGIWNQ 480
Query: 543 KSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLE 602
K +F+ DL GL ++++ A MN+ + CE++Y+F H++ Q+F AA+YY+LE +
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
Query: 603 IEPALCP---LYVEKTKRSMELKQAGFHI--HSLWMKRFLFGLVSEDVRRPLEVLLGCPV 657
P L + ++ L+ G + +++ RFLFGLV+++ LE L C +
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
Query: 658 PLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQN 717
++ +LL W+ + + L+ F+CL+E Q+++FV+ A++ F ++ + ++
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
Query: 718 LDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEA-----CPVVPLWMRDKT-------- 764
+D + SSFC+++C + + + P++E E +V + +
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
Query: 765 ----LIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNA 820
L E D +L ++ L +LDL + L + ++ LC L+H C ++ L N+
Sbjct: 721 GRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNS 780
Query: 821 QITP-GVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLT 879
+T L ++ N+NL L L G L ++ +++ CE L HP C L+ L LD C LT
Sbjct: 781 GLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLT 840
Query: 880 HACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILED 932
C +S +LT+S SL+ LSL N + D GVM + L+ C LQ L L +
Sbjct: 841 SHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 893
Score = 132 bits (332), Expect = 2e-30
Identities = 72/169 (42%), Positives = 102/169 (60%)
Query: 933 CGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHL 992
CG++ C ++ L SN+ L L LS+N+LG+ G+ LLC ++ C+L++L L L
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 782
Query: 993 DTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAA 1052
+ C L+ L N LTHL L N + D G+KLLCE + P C LQ LEL C+LT+
Sbjct: 783 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 842
Query: 1053 CCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGL 1101
CC LS +++ S+ L+ L L +N LGD GV CE LKQ++ +L LGL
Sbjct: 843 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
Score = 130 bits (326), Expect = 1e-29
Identities = 80/216 (37%), Positives = 120/216 (55%), Gaps = 10/216 (4%)
Query: 839 LRSLNLGGTH---LKEEDVRMACEALKHPKCLLESLR-------LDCCGLTHACYLKISQ 888
+ SL+LG H +EE+ L +C+L S L CGL+H C IS
Sbjct: 676 VESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL 735
Query: 889 ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948
+L+++ L L L+ N + D G+ L L+ C L+KL L + G+T+ C +L+S L
Sbjct: 736 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLS 795
Query: 949 SNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNS 1008
+N++LTHL L N+LG++G+ LLC + P C LQ L L+ C+L + C L+ L +
Sbjct: 796 TNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQ 855
Query: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
L LSL N + D GV + CEV+++ SC LQ+L L
Sbjct: 856 SLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
Score = 124 bits (310), Expect = 7e-28
Identities = 75/203 (36%), Positives = 107/203 (52%), Gaps = 2/203 (0%)
Query: 987 LNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVK 1046
L +C L C ++L L N L L LS N + D G++LLC ++ C+L+ L LV
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 1047 CHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGL 1106
LT+ CC +LS V+S +++L L L N LGD G+ LCEGL + L L L C L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 1107 TSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQ 1166
TS CC LS L+ ++ L L+L N+ G+M C + LQ +GL + + +
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYE 899
Query: 1167 IRKLLEEVQLLKPR--VVIDGSW 1187
+ LE +Q KP VV + SW
Sbjct: 900 TKSALETLQEEKPELTVVFEPSW 922
Score = 40.4 bits (93), Expect = 0.010
Identities = 22/59 (37%), Positives = 30/59 (50%)
Query: 1100 GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
GL CGL+ +CC +SL LS N+ L L+L N G+ LC NL+ + L
Sbjct: 719 GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 777
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 322 bits (826), Expect = 1e-87
Identities = 210/660 (31%), Positives = 341/660 (51%), Gaps = 34/660 (5%)
Query: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISR 338
PR V+L G +GIGKS LAR++ W +G LY F +VF+ RE+ + K S+ E I +
Sbjct: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGK 386
Query: 339 EWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRK 397
+ + AP+ +I+SRPERLLFI+DG D+ G VL ++LC W++ QP L+ SLL K
Sbjct: 387 DGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGK 446
Query: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRA 457
+LPE+ ++T R + L + R++ V G S R E Q + R
Sbjct: 447 TILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRL 506
Query: 458 IMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVR 517
+ +N+EL C VP V L C L Q E + ++T T L ++ L + +
Sbjct: 507 VKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGP 566
Query: 518 RCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCE 577
+ L+ C +A EG+W +K++F DDL GL + + M I L +
Sbjct: 567 Q---------LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI-LQEHPIP 616
Query: 578 EYYTFFHLSLQDFCAALYYVLEGLE--IEPALCPLYVEKTKRSMELKQAGFH-IHSLWMK 634
Y+F HL Q+F AA+ YVLE + + + C + +EKT L+ G H +
Sbjct: 617 LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKT-----LEAYGIHGLFGASTT 671
Query: 635 RFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLG--QQPNATTPGDTLDAFHCLF 692
RFL GL+S++ R +E + C + G + L+ WV L QP+ +L++ HCL+
Sbjct: 672 RFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPH------SLESLHCLY 723
Query: 693 ETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEA 752
ET++K F+ + F+E+ + + +++L+ +FC++ +++K+++ I R +
Sbjct: 724 ETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL----IEGRQHRSTW 779
Query: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
P + + R + + W+ S+L +L++LDL + L+ A+K+LC LR P C +
Sbjct: 780 SPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLL 839
Query: 813 QTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
+TL +T + L + AN+ L L+L L + + C+ L+ P C L+ L
Sbjct: 840 ETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRL 899
Query: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
+L CGLT C ++ +L+ SPSLK L L N + D GV L + LR C L +L L+
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLD 959
Score = 139 bits (351), Expect = 1e-32
Identities = 80/180 (44%), Positives = 100/180 (55%)
Query: 935 ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994
+T Q L S L R+L L LS NSL + V LC+++R P C L+ L L C L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 995 AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054
C LA L N LT L LS N + D G K LC+ +R+PSC LQ L+LV C LT+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEAL 1114
+ L+ V+S S LK LDL N L D GV LCEGL+ L RLGL L+ + + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 116 bits (290), Expect = 1e-25
Identities = 66/174 (37%), Positives = 96/174 (55%)
Query: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069
L L LS N + + VK LC+ +R P C L+ L L C LTA C+ L+ + ++ L
Sbjct: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
Query: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129
LDL+ N L D G LC+ L+Q + L RL L +CGLTSDCC+ L+ LS + L L+L
Sbjct: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Query: 1130 VQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVI 1183
QNN G+ LC P L +GL + ++R+ L ++ KP+++I
Sbjct: 930 QQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
Score = 115 bits (289), Expect = 2e-25
Identities = 67/167 (40%), Positives = 93/167 (55%)
Query: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
+T A + + +L + +LK L L+GN ++ V L LR +C L+ L L CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
C+ LA L +N++LT L LS N L + G LC+ +R P C LQRL L C L + C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
LA L + L L L N ++D GV+LLCE +R P+C L L L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 68.2 bits (165), Expect = 5e-11
Identities = 39/110 (35%), Positives = 60/110 (54%)
Query: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
+T A + L V+ +R+LK LDL+ N+L V +LC+ L++ +L L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
+ C+ L+ L N+ LT L+L N + G LC P+ LQ + L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Score = 39.3 bits (90), Expect = 0.023
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 62 SYGLQWCLYE-LDKEEFQTFKELLKKKS-SESTTCSIPQFEIENANVECLALLLHEYYGA 119
++G C E L KEE + F+ LL K+ S S++ P + + +E + L+ + YG
Sbjct: 5 AWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ-YGE 63
Query: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDP 154
AW ++ +E M LR+L +A++ HSP P
Sbjct: 64 QRAWDLALHTWEQMGLRSLCAQAQEG-AGHSPSFP 97
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 322 bits (826), Expect = 1e-87
Identities = 210/660 (31%), Positives = 341/660 (51%), Gaps = 34/660 (5%)
Query: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISR 338
PR V+L G +GIGKS LAR++ W +G LY F +VF+ RE+ + K S+ E I +
Sbjct: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGK 386
Query: 339 EWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRK 397
+ + AP+ +I+SRPERLLFI+DG D+ G VL ++LC W++ QP L+ SLL K
Sbjct: 387 DGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGK 446
Query: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRA 457
+LPE+ ++T R + L + R++ V G S R E Q + R
Sbjct: 447 TILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRL 506
Query: 458 IMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVR 517
+ +N+EL C VP V L C L Q E + ++T T L ++ L + +
Sbjct: 507 VKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGP 566
Query: 518 RCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCE 577
+ L+ C +A EG+W +K++F DDL GL + + M I L +
Sbjct: 567 Q---------LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI-LQEHPIP 616
Query: 578 EYYTFFHLSLQDFCAALYYVLEGLE--IEPALCPLYVEKTKRSMELKQAGFH-IHSLWMK 634
Y+F HL Q+F AA+ YVLE + + + C + +EKT L+ G H +
Sbjct: 617 LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKT-----LEAYGIHGLFGASTT 671
Query: 635 RFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLG--QQPNATTPGDTLDAFHCLF 692
RFL GL+S++ R +E + C + G + L+ WV L QP+ +L++ HCL+
Sbjct: 672 RFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPH------SLESLHCLY 723
Query: 693 ETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEA 752
ET++K F+ + F+E+ + + +++L+ +FC++ +++K+++ I R +
Sbjct: 724 ETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL----IEGRQHRSTW 779
Query: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
P + + R + + W+ S+L +L++LDL + L+ A+K+LC LR P C +
Sbjct: 780 SPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLL 839
Query: 813 QTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
+TL +T + L + AN+ L L+L L + + C+ L+ P C L+ L
Sbjct: 840 ETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRL 899
Query: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
+L CGLT C ++ +L+ SPSLK L L N + D GV L + LR C L +L L+
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLD 959
Score = 139 bits (351), Expect = 1e-32
Identities = 80/180 (44%), Positives = 100/180 (55%)
Query: 935 ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994
+T Q L S L R+L L LS NSL + V LC+++R P C L+ L L C L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 995 AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054
C LA L N LT L LS N + D G K LC+ +R+PSC LQ L+LV C LT+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEAL 1114
+ L+ V+S S LK LDL N L D GV LCEGL+ L RLGL L+ + + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 116 bits (290), Expect = 1e-25
Identities = 66/174 (37%), Positives = 96/174 (55%)
Query: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069
L L LS N + + VK LC+ +R P C L+ L L C LTA C+ L+ + ++ L
Sbjct: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
Query: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129
LDL+ N L D G LC+ L+Q + L RL L +CGLTSDCC+ L+ LS + L L+L
Sbjct: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Query: 1130 VQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVI 1183
QNN G+ LC P L +GL + ++R+ L ++ KP+++I
Sbjct: 930 QQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
Score = 115 bits (289), Expect = 2e-25
Identities = 67/167 (40%), Positives = 93/167 (55%)
Query: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
+T A + + +L + +LK L L+GN ++ V L LR +C L+ L L CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
C+ LA L +N++LT L LS N L + G LC+ +R P C LQRL L C L + C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
LA L + L L L N ++D GV+LLCE +R P+C L L L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 68.2 bits (165), Expect = 5e-11
Identities = 39/110 (35%), Positives = 60/110 (54%)
Query: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
+T A + L V+ +R+LK LDL+ N+L V +LC+ L++ +L L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
+ C+ L+ L N+ LT L+L N + G LC P+ LQ + L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Score = 39.3 bits (90), Expect = 0.023
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 62 SYGLQWCLYE-LDKEEFQTFKELLKKKS-SESTTCSIPQFEIENANVECLALLLHEYYGA 119
++G C E L KEE + F+ LL K+ S S++ P + + +E + L+ + YG
Sbjct: 5 AWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ-YGE 63
Query: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDP 154
AW ++ +E M LR+L +A++ HSP P
Sbjct: 64 QRAWDLALHTWEQMGLRSLCAQAQEG-AGHSPSFP 97
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 322 bits (826), Expect = 1e-87
Identities = 210/660 (31%), Positives = 341/660 (51%), Gaps = 34/660 (5%)
Query: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISR 338
PR V+L G +GIGKS LAR++ W +G LY F +VF+ RE+ + K S+ E I +
Sbjct: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGK 386
Query: 339 EWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRK 397
+ + AP+ +I+SRPERLLFI+DG D+ G VL ++LC W++ QP L+ SLL K
Sbjct: 387 DGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGK 446
Query: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRA 457
+LPE+ ++T R + L + R++ V G S R E Q + R
Sbjct: 447 TILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRL 506
Query: 458 IMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVR 517
+ +N+EL C VP V L C L Q E + ++T T L ++ L + +
Sbjct: 507 VKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGP 566
Query: 518 RCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCE 577
+ L+ C +A EG+W +K++F DDL GL + + M I L +
Sbjct: 567 Q---------LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI-LQEHPIP 616
Query: 578 EYYTFFHLSLQDFCAALYYVLEGLE--IEPALCPLYVEKTKRSMELKQAGFH-IHSLWMK 634
Y+F HL Q+F AA+ YVLE + + + C + +EKT L+ G H +
Sbjct: 617 LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKT-----LEAYGIHGLFGASTT 671
Query: 635 RFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLG--QQPNATTPGDTLDAFHCLF 692
RFL GL+S++ R +E + C + G + L+ WV L QP+ +L++ HCL+
Sbjct: 672 RFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPH------SLESLHCLY 723
Query: 693 ETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEA 752
ET++K F+ + F+E+ + + +++L+ +FC++ +++K+++ I R +
Sbjct: 724 ETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL----IEGRQHRSTW 779
Query: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
P + + R + + W+ S+L +L++LDL + L+ A+K+LC LR P C +
Sbjct: 780 SPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLL 839
Query: 813 QTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
+TL +T + L + AN+ L L+L L + + C+ L+ P C L+ L
Sbjct: 840 ETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRL 899
Query: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
+L CGLT C ++ +L+ SPSLK L L N + D GV L + LR C L +L L+
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLD 959
Score = 139 bits (351), Expect = 1e-32
Identities = 80/180 (44%), Positives = 100/180 (55%)
Query: 935 ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994
+T Q L S L R+L L LS NSL + V LC+++R P C L+ L L C L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 995 AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054
C LA L N LT L LS N + D G K LC+ +R+PSC LQ L+LV C LT+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEAL 1114
+ L+ V+S S LK LDL N L D GV LCEGL+ L RLGL L+ + + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 116 bits (290), Expect = 1e-25
Identities = 66/174 (37%), Positives = 96/174 (55%)
Query: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069
L L LS N + + VK LC+ +R P C L+ L L C LTA C+ L+ + ++ L
Sbjct: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
Query: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129
LDL+ N L D G LC+ L+Q + L RL L +CGLTSDCC+ L+ LS + L L+L
Sbjct: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Query: 1130 VQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVI 1183
QNN G+ LC P L +GL + ++R+ L ++ KP+++I
Sbjct: 930 QQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
Score = 115 bits (289), Expect = 2e-25
Identities = 67/167 (40%), Positives = 93/167 (55%)
Query: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
+T A + + +L + +LK L L+GN ++ V L LR +C L+ L L CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
C+ LA L +N++LT L LS N L + G LC+ +R P C LQRL L C L + C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
LA L + L L L N ++D GV+LLCE +R P+C L L L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 68.2 bits (165), Expect = 5e-11
Identities = 39/110 (35%), Positives = 60/110 (54%)
Query: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
+T A + L V+ +R+LK LDL+ N+L V +LC+ L++ +L L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
+ C+ L+ L N+ LT L+L N + G LC P+ LQ + L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Score = 39.3 bits (90), Expect = 0.023
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 62 SYGLQWCLYE-LDKEEFQTFKELLKKKS-SESTTCSIPQFEIENANVECLALLLHEYYGA 119
++G C E L KEE + F+ LL K+ S S++ P + + +E + L+ + YG
Sbjct: 5 AWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ-YGE 63
Query: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDP 154
AW ++ +E M LR+L +A++ HSP P
Sbjct: 64 QRAWDLALHTWEQMGLRSLCAQAQEG-AGHSPSFP 97
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 322 bits (824), Expect = 2e-87
Identities = 209/657 (31%), Positives = 339/657 (51%), Gaps = 34/657 (5%)
Query: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISR 338
PR V+L G +GIGKS LAR++ W +G LY F +VF+ RE+ + K S+ E I +
Sbjct: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGK 386
Query: 339 EWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRK 397
+ + AP+ +I+SRPERLLFI+DG D+ G VL ++LC W++ QP L+ SLL K
Sbjct: 387 DGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGK 446
Query: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRA 457
+LPE+ ++T R + L + R++ V G S R E Q + R
Sbjct: 447 TILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRL 506
Query: 458 IMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVR 517
+ +N+EL C VP V L C L Q E + ++T T L ++ L + +
Sbjct: 507 VKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGP 566
Query: 518 RCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCE 577
+ L+ C +A EG+W +K++F DDL GL + + M I L +
Sbjct: 567 Q---------LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI-LQEHPIP 616
Query: 578 EYYTFFHLSLQDFCAALYYVLEGLE--IEPALCPLYVEKTKRSMELKQAGFH-IHSLWMK 634
Y+F HL Q+F AA+ YVLE + + + C + +EKT L+ G H +
Sbjct: 617 LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKT-----LEAYGIHGLFGASTT 671
Query: 635 RFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLG--QQPNATTPGDTLDAFHCLF 692
RFL GL+S++ R +E + C + G + L+ WV L QP+ +L++ HCL+
Sbjct: 672 RFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPH------SLESLHCLY 723
Query: 693 ETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEA 752
ET++K F+ + F+E+ + + +++L+ +FC++ +++K+++ I R +
Sbjct: 724 ETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL----IEGRQHRSTW 779
Query: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
P + + R + + W+ S+L +L++LDL + L+ A+K+LC LR P C +
Sbjct: 780 SPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLL 839
Query: 813 QTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
+TL +T + L + AN+ L L+L L + + C+ L+ P C L+ L
Sbjct: 840 ETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRL 899
Query: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKL 928
+L CGLT C ++ +L+ SPSLK L L N + D GV L + LR C L +L
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 137 bits (344), Expect = 8e-32
Identities = 77/166 (46%), Positives = 94/166 (56%)
Query: 935 ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994
+T Q L S L R+L L LS NSL + V LC+++R P C L+ L L C L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 995 AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054
C LA L N LT L LS N + D G K LC+ +R+PSC LQ L+LV C LT+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLG 1100
+ L+ V+S S LK LDL N L D GV LCEGL+ L RLG
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 115 bits (288), Expect = 2e-25
Identities = 65/162 (40%), Positives = 91/162 (56%)
Query: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
+T A + + +L + +LK L L+GN ++ V L LR +C L+ L L CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
C+ LA L +N++LT L LS N L + G LC+ +R P C LQRL L C L + C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHL 1039
LA L + L L L N ++D GV+LLCE +R P+C L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 108 bits (271), Expect = 2e-23
Identities = 60/148 (40%), Positives = 81/148 (54%)
Query: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069
L L LS N + + VK LC+ +R P C L+ L L C LTA C+ L+ + ++ L
Sbjct: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
Query: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129
LDL+ N L D G LC+ L+Q + L RL L +CGLTSDCC+ L+ LS + L L+L
Sbjct: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Query: 1130 VQNNFSPKGMMKLCSAFACPTSNLQIIG 1157
QNN G+ LC P L +G
Sbjct: 930 QQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 68.2 bits (165), Expect = 5e-11
Identities = 39/110 (35%), Positives = 60/110 (54%)
Query: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
+T A + L V+ +R+LK LDL+ N+L V +LC+ L++ +L L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
+ C+ L+ L N+ LT L+L N + G LC P+ LQ + L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Score = 39.3 bits (90), Expect = 0.023
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 62 SYGLQWCLYE-LDKEEFQTFKELLKKKS-SESTTCSIPQFEIENANVECLALLLHEYYGA 119
++G C E L KEE + F+ LL K+ S S++ P + + +E + L+ + YG
Sbjct: 5 AWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ-YGE 63
Query: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDP 154
AW ++ +E M LR+L +A++ HSP P
Sbjct: 64 QRAWDLALHTWEQMGLRSLCAQAQEG-AGHSPSFP 97
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 322 bits (824), Expect = 2e-87
Identities = 209/657 (31%), Positives = 339/657 (51%), Gaps = 34/657 (5%)
Query: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISR 338
PR V+L G +GIGKS LAR++ W +G LY F +VF+ RE+ + K S+ E I +
Sbjct: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGK 386
Query: 339 EWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRK 397
+ + AP+ +I+SRPERLLFI+DG D+ G VL ++LC W++ QP L+ SLL K
Sbjct: 387 DGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGK 446
Query: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRA 457
+LPE+ ++T R + L + R++ V G S R E Q + R
Sbjct: 447 TILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRL 506
Query: 458 IMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVR 517
+ +N+EL C VP V L C L Q E + ++T T L ++ L + +
Sbjct: 507 VKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGP 566
Query: 518 RCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCE 577
+ L+ C +A EG+W +K++F DDL GL + + M I L +
Sbjct: 567 Q---------LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI-LQEHPIP 616
Query: 578 EYYTFFHLSLQDFCAALYYVLEGLE--IEPALCPLYVEKTKRSMELKQAGFH-IHSLWMK 634
Y+F HL Q+F AA+ YVLE + + + C + +EKT L+ G H +
Sbjct: 617 LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKT-----LEAYGIHGLFGASTT 671
Query: 635 RFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLG--QQPNATTPGDTLDAFHCLF 692
RFL GL+S++ R +E + C + G + L+ WV L QP+ +L++ HCL+
Sbjct: 672 RFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPH------SLESLHCLY 723
Query: 693 ETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEA 752
ET++K F+ + F+E+ + + +++L+ +FC++ +++K+++ I R +
Sbjct: 724 ETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL----IEGRQHRSTW 779
Query: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
P + + R + + W+ S+L +L++LDL + L+ A+K+LC LR P C +
Sbjct: 780 SPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLL 839
Query: 813 QTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
+TL +T + L + AN+ L L+L L + + C+ L+ P C L+ L
Sbjct: 840 ETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRL 899
Query: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKL 928
+L CGLT C ++ +L+ SPSLK L L N + D GV L + LR C L +L
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 137 bits (344), Expect = 8e-32
Identities = 77/166 (46%), Positives = 94/166 (56%)
Query: 935 ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994
+T Q L S L R+L L LS NSL + V LC+++R P C L+ L L C L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 995 AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054
C LA L N LT L LS N + D G K LC+ +R+PSC LQ L+LV C LT+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLG 1100
+ L+ V+S S LK LDL N L D GV LCEGL+ L RLG
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 115 bits (288), Expect = 2e-25
Identities = 65/162 (40%), Positives = 91/162 (56%)
Query: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
+T A + + +L + +LK L L+GN ++ V L LR +C L+ L L CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
C+ LA L +N++LT L LS N L + G LC+ +R P C LQRL L C L + C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHL 1039
LA L + L L L N ++D GV+LLCE +R P+C L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 108 bits (271), Expect = 2e-23
Identities = 60/148 (40%), Positives = 81/148 (54%)
Query: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069
L L LS N + + VK LC+ +R P C L+ L L C LTA C+ L+ + ++ L
Sbjct: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
Query: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129
LDL+ N L D G LC+ L+Q + L RL L +CGLTSDCC+ L+ LS + L L+L
Sbjct: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Query: 1130 VQNNFSPKGMMKLCSAFACPTSNLQIIG 1157
QNN G+ LC P L +G
Sbjct: 930 QQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 68.2 bits (165), Expect = 5e-11
Identities = 39/110 (35%), Positives = 60/110 (54%)
Query: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
+T A + L V+ +R+LK LDL+ N+L V +LC+ L++ +L L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
+ C+ L+ L N+ LT L+L N + G LC P+ LQ + L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Score = 39.3 bits (90), Expect = 0.023
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 62 SYGLQWCLYE-LDKEEFQTFKELLKKKS-SESTTCSIPQFEIENANVECLALLLHEYYGA 119
++G C E L KEE + F+ LL K+ S S++ P + + +E + L+ + YG
Sbjct: 5 AWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ-YGE 63
Query: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDP 154
AW ++ +E M LR+L +A++ HSP P
Sbjct: 64 QRAWDLALHTWEQMGLRSLCAQAQEG-AGHSPSFP 97
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 238 bits (607), Expect = 3e-62
Identities = 236/912 (25%), Positives = 384/912 (42%), Gaps = 113/912 (12%)
Query: 69 LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128
L EL +E+ + F+ L+ + SIP +E A+ LA L ++YG A
Sbjct: 26 LEELSQEQLKRFRHKLRDVGPDGR--SIPWGRLERADAVDLAEQLAQFYGPEPAL----- 78
Query: 129 IFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQ 188
E AR +KR D A + ++ + + + +
Sbjct: 79 -----------EVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKKKYREHVL 127
Query: 189 EISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEED 248
++ +++ A + + ++ + E +AA E G AEE +
Sbjct: 128 QLHARVKERNARSVKITKRFTKLLIAPE--SAAPEEALGP---------------AEEPE 170
Query: 249 VRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGL 308
R+ + + T F D G RP TVVL G +GIGK+ A++I+ WA G L
Sbjct: 171 PGRARRS------DTHTFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKL 224
Query: 309 YQGMFSYVFFLPVREM-QRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDL 367
YQG + FF+P E+ +R S+ + I + PD APV +++++P+RLLFI+DG D+L
Sbjct: 225 YQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADEL 284
Query: 368 GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYL 427
++ + C D E ++ LL K LLP + L+VT R +L+ + SP+
Sbjct: 285 PALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCA 344
Query: 428 LVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVV 487
VRG S + + + E + + R + N L C VP V ++C L+ Q +
Sbjct: 345 EVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLEL 404
Query: 488 GESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFD 547
G ++ ++T T ++ F+ L+ V + L+ CR+A EGV R++ F
Sbjct: 405 GRDLSRTSKTTTSVYLLFITSVLSSAPVAD---GPRLQGDLRNLCRLAREGVLGRRAQFA 461
Query: 548 GDDLMVQGLGESELRALFHMNILLPD-SHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPA 606
+L L S+++ LF LP E Y F S Q+F AAL Y+LE +
Sbjct: 462 EKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGV--- 518
Query: 607 LCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLL 666
P ++ A H H + RFLFGL+S + R +E GC V VKQ+ L
Sbjct: 519 --PRTAAGGVGTLLRGDAQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEAL 576
Query: 667 HWVSLLGQ------------------------QPNATTPGDTLDAFHCLFETQDKEFVRL 702
WV GQ + P L+ +CL+ETQ+ FVR
Sbjct: 577 RWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQ 636
Query: 703 ALNSFQEVWLPINQ--NLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWM 760
AL F E+ L + +D+ S+C++ CP + +R+ +C +V
Sbjct: 637 ALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRL------------ISCRLVAAQE 684
Query: 761 RDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRH--------PTCKI 812
+ K + ++ Q LG ++ K L A L H P C +
Sbjct: 685 KKKKSLGKR--------------LQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHL 730
Query: 813 QTLMFRNAQITPGV-QHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
+L + ++ V + L + A L L L L E +RM E L P+C ++++
Sbjct: 731 SSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTV 790
Query: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
R+ + +L SP+L +L L+G ++ V L L+ C LQ L L
Sbjct: 791 RVQLPDPQRGLQYLVG-MLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLA 849
Query: 932 DCGITATGCQSL 943
++ Q L
Sbjct: 850 SVELSEQSLQEL 861
Score = 59.7 bits (143), Expect = 2e-08
Identities = 44/148 (29%), Positives = 64/148 (43%), Gaps = 1/148 (0%)
Query: 913 PLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLC 972
PL A+ C L L L C + C+ L+ AL + +LT L L +N L G+ +L
Sbjct: 718 PLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLS 777
Query: 973 RSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVM 1032
+ P C +Q + + Q G +L L + LT L LS + V LC V+
Sbjct: 778 EGLAWPQCRVQTVRV-QLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVL 836
Query: 1033 REPSCHLQDLELVKCHLTAACCESLSCV 1060
+ C LQ L L L+ + L V
Sbjct: 837 QHQGCGLQTLSLASVELSEQSLQELQAV 864
Score = 58.9 bits (141), Expect = 3e-08
Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 1/134 (0%)
Query: 859 EALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDAL 918
+A+ P C L SL L C L A +S+ L +P+L L L N++++ G+ LS+ L
Sbjct: 721 QAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGL 780
Query: 919 RVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLP 978
QC +Q + ++ G Q L L + +LT L LS L V LC ++
Sbjct: 781 AWPQCRVQTVRVQ-LPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQ 839
Query: 979 HCSLQRLMLNQCHL 992
C LQ L L L
Sbjct: 840 GCGLQTLSLASVEL 853
Score = 49.7 bits (117), Expect = 2e-05
Identities = 42/144 (29%), Positives = 66/144 (45%), Gaps = 1/144 (0%)
Query: 971 LCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCE 1030
L ++M P C L L L+ C L A C L+ AL LT L L N + + G+++L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 1031 VMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLK 1090
+ P C +Q + V+ + L ++ +S L +LDL+ L V LC L+
Sbjct: 779 GLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 1091 QKNSVLARLGLKACGLTSDCCEAL 1114
+ L L L + L+ + L
Sbjct: 838 HQGCGLQTLSLASVELSEQSLQEL 861
Score = 48.1 bits (113), Expect = 5e-05
Identities = 46/160 (28%), Positives = 67/160 (41%), Gaps = 9/160 (5%)
Query: 1028 LCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCE 1087
L + M +P CHL L L C L A C LS + + L L L N L + G+ L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 1088 GLK----QKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLC 1143
GL + +V +L GL + L L + LT+L+L + LC
Sbjct: 779 GLAWPQCRVQTVRVQLPDPQRGL-----QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833
Query: 1144 SAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVI 1183
+ LQ + L + Q + L+ V+ KP +VI
Sbjct: 834 AVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 237 bits (604), Expect = 6e-62
Identities = 142/430 (33%), Positives = 221/430 (51%), Gaps = 3/430 (0%)
Query: 751 EACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC 810
+ C VV L D L E + +D S L +P L +L+L S+ L + + + L+ P+C
Sbjct: 28 QQCQVVRL--DDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 811 KIQTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE 869
KIQ L +N +T G L + L+ L+L L + +++ CE L P+C LE
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 870 SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLI 929
L+L+ C L+ A ++ +L P K L+++ N + + GV L L+ S C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 930 LEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQ 989
LE CG+T+ C+ L + S SL L L +N LG+ G+ LC + P L+ L + +
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 990 CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHL 1049
C + GCG L L L LSL+ N + D G +LLCE + EP C L+ L + C
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 1050 TAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSD 1109
TAACC S V++++R L L +++N L D GV LC+GL Q SVL L L C ++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 1110 CCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRK 1169
C +L+ L N L L+L N G+++L + P L+ + L+ + ++
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 1170 LLEEVQLLKP 1179
L+ ++ KP
Sbjct: 446 RLQALEKDKP 455
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 237 bits (604), Expect = 6e-62
Identities = 142/430 (33%), Positives = 221/430 (51%), Gaps = 3/430 (0%)
Query: 751 EACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC 810
+ C VV L D L E + +D S L +P L +L+L S+ L + + + L+ P+C
Sbjct: 28 QQCQVVRL--DDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 811 KIQTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE 869
KIQ L +N +T G L + L+ L+L L + +++ CE L P+C LE
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 870 SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLI 929
L+L+ C L+ A ++ +L P K L+++ N + + GV L L+ S C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 930 LEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQ 989
LE CG+T+ C+ L + S SL L L +N LG+ G+ LC + P L+ L + +
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 990 CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHL 1049
C + GCG L L L LSL+ N + D G +LLCE + EP C L+ L + C
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 1050 TAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSD 1109
TAACC S V++++R L L +++N L D GV LC+GL Q SVL L L C ++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 1110 CCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRK 1169
C +L+ L N L L+L N G+++L + P L+ + L+ + ++
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 1170 LLEEVQLLKP 1179
L+ ++ KP
Sbjct: 446 RLQALEKDKP 455
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 237 bits (604), Expect = 6e-62
Identities = 142/430 (33%), Positives = 221/430 (51%), Gaps = 3/430 (0%)
Query: 751 EACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC 810
+ C VV L D L E + +D S L +P L +L+L S+ L + + + L+ P+C
Sbjct: 28 QQCQVVRL--DDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 811 KIQTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE 869
KIQ L +N +T G L + L+ L+L L + +++ CE L P+C LE
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 870 SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLI 929
L+L+ C L+ A ++ +L P K L+++ N + + GV L L+ S C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 930 LEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQ 989
LE CG+T+ C+ L + S SL L L +N LG+ G+ LC + P L+ L + +
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 990 CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHL 1049
C + GCG L L L LSL+ N + D G +LLCE + EP C L+ L + C
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 1050 TAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSD 1109
TAACC S V++++R L L +++N L D GV LC+GL Q SVL L L C ++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 1110 CCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRK 1169
C +L+ L N L L+L N G+++L + P L+ + L+ + ++
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 1170 LLEEVQLLKP 1179
L+ ++ KP
Sbjct: 446 RLQALEKDKP 455
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 237 bits (604), Expect = 6e-62
Identities = 142/430 (33%), Positives = 221/430 (51%), Gaps = 3/430 (0%)
Query: 751 EACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC 810
+ C VV L D L E + +D S L +P L +L+L S+ L + + + L+ P+C
Sbjct: 28 QQCQVVRL--DDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 811 KIQTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE 869
KIQ L +N +T G L + L+ L+L L + +++ CE L P+C LE
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 870 SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLI 929
L+L+ C L+ A ++ +L P K L+++ N + + GV L L+ S C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 930 LEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQ 989
LE CG+T+ C+ L + S SL L L +N LG+ G+ LC + P L+ L + +
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 990 CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHL 1049
C + GCG L L L LSL+ N + D G +LLCE + EP C L+ L + C
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 1050 TAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSD 1109
TAACC S V++++R L L +++N L D GV LC+GL Q SVL L L C ++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 1110 CCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRK 1169
C +L+ L N L L+L N G+++L + P L+ + L+ + ++
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 1170 LLEEVQLLKP 1179
L+ ++ KP
Sbjct: 446 RLQALEKDKP 455
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 237 bits (604), Expect = 6e-62
Identities = 142/430 (33%), Positives = 221/430 (51%), Gaps = 3/430 (0%)
Query: 751 EACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC 810
+ C VV L D L E + +D S L +P L +L+L S+ L + + + L+ P+C
Sbjct: 28 QQCQVVRL--DDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 811 KIQTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE 869
KIQ L +N +T G L + L+ L+L L + +++ CE L P+C LE
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 870 SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLI 929
L+L+ C L+ A ++ +L P K L+++ N + + GV L L+ S C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 930 LEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQ 989
LE CG+T+ C+ L + S SL L L +N LG+ G+ LC + P L+ L + +
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 990 CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHL 1049
C + GCG L L L LSL+ N + D G +LLCE + EP C L+ L + C
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 1050 TAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSD 1109
TAACC S V++++R L L +++N L D GV LC+GL Q SVL L L C ++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 1110 CCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRK 1169
C +L+ L N L L+L N G+++L + P L+ + L+ + ++
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 1170 LLEEVQLLKP 1179
L+ ++ KP
Sbjct: 446 RLQALEKDKP 455
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 237 bits (604), Expect = 6e-62
Identities = 142/430 (33%), Positives = 221/430 (51%), Gaps = 3/430 (0%)
Query: 751 EACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC 810
+ C VV L D L E + +D S L +P L +L+L S+ L + + + L+ P+C
Sbjct: 28 QQCQVVRL--DDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 811 KIQTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE 869
KIQ L +N +T G L + L+ L+L L + +++ CE L P+C LE
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 870 SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLI 929
L+L+ C L+ A ++ +L P K L+++ N + + GV L L+ S C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 930 LEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQ 989
LE CG+T+ C+ L + S SL L L +N LG+ G+ LC + P L+ L + +
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 990 CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHL 1049
C + GCG L L L LSL+ N + D G +LLCE + EP C L+ L + C
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 1050 TAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSD 1109
TAACC S V++++R L L +++N L D GV LC+GL Q SVL L L C ++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 1110 CCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRK 1169
C +L+ L N L L+L N G+++L + P L+ + L+ + ++
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 1170 LLEEVQLLKP 1179
L+ ++ KP
Sbjct: 446 RLQALEKDKP 455
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 237 bits (604), Expect = 6e-62
Identities = 142/430 (33%), Positives = 221/430 (51%), Gaps = 3/430 (0%)
Query: 751 EACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC 810
+ C VV L D L E + +D S L +P L +L+L S+ L + + + L+ P+C
Sbjct: 28 QQCQVVRL--DDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 811 KIQTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE 869
KIQ L +N +T G L + L+ L+L L + +++ CE L P+C LE
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 870 SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLI 929
L+L+ C L+ A ++ +L P K L+++ N + + GV L L+ S C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 930 LEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQ 989
LE CG+T+ C+ L + S SL L L +N LG+ G+ LC + P L+ L + +
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 990 CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHL 1049
C + GCG L L L LSL+ N + D G +LLCE + EP C L+ L + C
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 1050 TAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSD 1109
TAACC S V++++R L L +++N L D GV LC+GL Q SVL L L C ++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 1110 CCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRK 1169
C +L+ L N L L+L N G+++L + P L+ + L+ + ++
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 1170 LLEEVQLLKP 1179
L+ ++ KP
Sbjct: 446 RLQALEKDKP 455
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,035,535
Number of Sequences: 37866
Number of extensions: 2058326
Number of successful extensions: 8722
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 110
Number of HSP's successfully gapped in prelim test: 128
Number of HSP's that attempted gapping in prelim test: 6920
Number of HSP's gapped (non-prelim): 908
length of query: 1200
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1086
effective length of database: 13,930,794
effective search space: 15128842284
effective search space used: 15128842284
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.