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Search of human proteins with 157743290
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
(301 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 606 e-174
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 120 1e-27
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 114 1e-25
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 113 2e-25
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 106 3e-23
gi|63003903 leucine rich repeat containing 10 [Homo sapiens] 105 4e-23
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 105 6e-23
gi|45827729 scribble isoform b [Homo sapiens] 102 3e-22
gi|45827731 scribble isoform a [Homo sapiens] 102 3e-22
gi|190014581 leucine rich repeat containing 2 [Homo sapiens] 102 5e-22
gi|27545328 leucine rich repeat containing 2 [Homo sapiens] 102 5e-22
gi|238908508 leucine-rich repeat and death domain-containing pro... 101 9e-22
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 100 2e-21
gi|61742786 leucine rich repeat and death domain containing prot... 99 4e-21
gi|61742784 leucine rich repeat and death domain containing prot... 99 4e-21
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 98 8e-21
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 94 2e-19
gi|223005922 leucine rich repeat containing 10-like [Homo sapiens] 92 4e-19
gi|4503743 flightless I homolog [Homo sapiens] 92 6e-19
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 92 6e-19
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 92 6e-19
gi|62241040 leucine rich repeat containing 8 family, member A [H... 92 7e-19
gi|187829877 leucine rich repeat containing 8 family, member A [... 92 7e-19
gi|187829871 leucine rich repeat containing 8 family, member A [... 92 7e-19
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 87 2e-17
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 87 2e-17
gi|61742782 leucine rich repeat and death domain containing prot... 87 2e-17
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 86 3e-17
gi|40217803 leucine rich repeat containing 8 family, member E [H... 86 4e-17
gi|197333692 leucine rich repeat containing 8 family, member B [... 83 3e-16
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 606 bits (1562), Expect = e-174
Identities = 301/301 (100%), Positives = 301/301 (100%)
Query: 1 MGARQSRASSKDKGPKRMLFTGRRQKFSPWDDALLSGRDPRSLLKRGMHHVSFSLVTRGM 60
MGARQSRASSKDKGPKRMLFTGRRQKFSPWDDALLSGRDPRSLLKRGMHHVSFSLVTRGM
Sbjct: 1 MGARQSRASSKDKGPKRMLFTGRRQKFSPWDDALLSGRDPRSLLKRGMHHVSFSLVTRGM 60
Query: 61 TDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLK 120
TDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLK
Sbjct: 61 TDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLK 120
Query: 121 VLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPM 180
VLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPM
Sbjct: 121 VLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPM 180
Query: 181 CVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLN 240
CVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLN
Sbjct: 181 CVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLN 240
Query: 241 NNDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFGYLKDKKH 300
NNDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFGYLKDKKH
Sbjct: 241 NNDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFGYLKDKKH 300
Query: 301 T 301
T
Sbjct: 301 T 301
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 120 bits (301), Expect = 1e-27
Identities = 81/243 (33%), Positives = 122/243 (50%), Gaps = 11/243 (4%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
+ +PD L LS ++ L++ HNQL P ++ +L + L++ NRL+ LP ++S L+ L
Sbjct: 170 LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRAL 229
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
K+L+++ L +PA LE L L +N L LPA F+ L RL+ LNLS+N F P
Sbjct: 230 KILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFP 289
Query: 180 MCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNL 239
+ L L L++ N+L ++ I L L + N I P S+ +T LE L L
Sbjct: 290 AALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVL 349
Query: 240 NNNDIQTLPSELHLLCRLVRIAWNPMDKGL-HISHNPLSKPLPELVEGGLEMLFGYLKDK 298
N I LP L R+ GL I NPL +P E+ G+ + Y K+
Sbjct: 350 QGNQIAVLPDHFGQLSRV----------GLWKIKDNPLIQPPYEVCMKGIPYIAAYQKEL 399
Query: 299 KHT 301
H+
Sbjct: 400 AHS 402
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 114 bits (284), Expect = 1e-25
Identities = 63/213 (29%), Positives = 114/213 (53%), Gaps = 1/213 (0%)
Query: 46 RGMHHVSF-SLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGN 104
+ +HH+ L + +P + ++++++ L NQ V P E+ L + +++L N
Sbjct: 139 KNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDEN 198
Query: 105 RLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSR 164
++ ++P E+ L L+ ++ N L +PA L C +L VL LSHN L +P FA+L +
Sbjct: 199 KIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRK 258
Query: 165 LRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSF 224
+ ++ LS N +P + L L++G+ L + S + L +L+ N++H
Sbjct: 259 MTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHC 318
Query: 225 PRSLCLVTSLELLNLNNNDIQTLPSELHLLCRL 257
P +C + +LE+L L++N I LPSEL L +L
Sbjct: 319 PLQICALKNLEVLGLDDNKIGQLPSELGSLSKL 351
Score = 102 bits (254), Expect = 4e-22
Identities = 80/288 (27%), Positives = 134/288 (46%), Gaps = 40/288 (13%)
Query: 53 FSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPRE 112
F + + + +P L S++ L+LSHN L +P +L ++ + L GNRL+ +PR
Sbjct: 216 FYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRL 275
Query: 113 VSLLQCLKVLF-----------------------VNMNCLTEVPAELSLCRKLEVLSLSH 149
+ L +L+ ++ N L P ++ + LEVL L
Sbjct: 276 ICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDD 335
Query: 150 NCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSN---RLENIAESIQ 206
N + QLP+ LS+L+ L L+ N F P V SL L L++G + +L + E I+
Sbjct: 336 NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIR 395
Query: 207 HLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLP---------SELHLLCRL 257
L SL+ E N++ P SL + +LE+L+ +N ++ LP EL L L
Sbjct: 396 KLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNL 455
Query: 258 VRIAWNPMD-----KGLHISHNPLSKPLPELVEGGLEMLFGYLKDKKH 300
+ +D K L + NP+ +P E+ G E ++ YLK+ ++
Sbjct: 456 LTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRN 503
Score = 86.7 bits (213), Expect = 2e-17
Identities = 64/228 (28%), Positives = 109/228 (47%), Gaps = 25/228 (10%)
Query: 58 RGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQ 117
+ +T IP ++ +E+++++L +NQ+ +P E+ +L I VL L N L+SL + LL
Sbjct: 35 QSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLS 94
Query: 118 CLKVLFVNMNC------------------------LTEVPAEL-SLCRKLEVLSLSHNCL 152
L+ L ++ N L E+P + LE+L L+ N L
Sbjct: 95 SLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHL 154
Query: 153 SQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQ 212
LP + ++LR++ L N F P + L L + + N++ I E I HL LQ
Sbjct: 155 KCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQ 214
Query: 213 IFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
F NN+ P SLC + L +L+L++N + ++P L ++ I
Sbjct: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEI 262
Score = 80.9 bits (198), Expect = 1e-15
Identities = 50/178 (28%), Positives = 94/178 (52%), Gaps = 2/178 (1%)
Query: 76 LNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAE 135
++ S+ L +P E+ T + ++L N+++ +P+E+ L+ ++VL+++ N L +
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 136 LSLCRKLEVLSLSHN-CLSQLPACFADLSRLRKLNLSNNFFAHIPMCVF-SLKELIFLHV 193
L L LE L LS+N S + L LR+L L IP+ +F +L L L +
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 194 GSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL 251
N L+ + + I + L+ + N FP+ LC++ +LE+++L+ N I +P E+
Sbjct: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEI 207
Score = 30.8 bits (68), Expect = 1.5
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 206 QHLASLQIFI-AEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLL 254
QH+ FI A ++ + P + T LE ++L NN I+ +P E+ L
Sbjct: 21 QHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRL 70
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 113 bits (282), Expect = 2e-25
Identities = 85/265 (32%), Positives = 129/265 (48%), Gaps = 39/265 (14%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
+T +P + L +QKLN+SHN+L++LP E+ L + L L N L + L L
Sbjct: 117 LTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNL 176
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
+ L ++ N LT VPA S L L+LS N L LPA + RL+ L+ ++N IP
Sbjct: 177 EDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIP 236
Query: 180 MCVFSLK--ELIFL--------------------HVGSNRLENI-AESIQHLASLQIFIA 216
+ ++ EL++L HVG N++E + AE ++HL S+ +
Sbjct: 237 PELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDL 296
Query: 217 EGNNIHSFPRSLCLVTSLELLNLNNNDIQTLP---SELHLLCRLVRIAWNPMDKGLHISH 273
N + S P + L+ SLE L+L+NNDI +LP LHL K L +
Sbjct: 297 RDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHL-------------KFLALEG 343
Query: 274 NPLSKPLPELVEGGLEMLFGYLKDK 298
NPL E++ G + + YL+ K
Sbjct: 344 NPLRTIRREIISKGTQEVLKYLRSK 368
Score = 101 bits (252), Expect = 7e-22
Identities = 82/291 (28%), Positives = 135/291 (46%), Gaps = 38/291 (13%)
Query: 37 GRD-----PRSLLKRGMHHVSFSLVTRGMTDIPDFLWGLS-------------------- 71
GRD P+ LLK +L R ++++P +W ++
Sbjct: 20 GRDCGTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWW 79
Query: 72 ---EVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNC 128
++ KL +S+N+L+ L ++ L + VL++ N+L SLP + L+ L+ L V+ N
Sbjct: 80 EQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNK 139
Query: 129 LTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKEL 188
L +P E++ R L+ L L HN L+ + F LS L L+LSNN +P SL L
Sbjct: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSL 199
Query: 189 IFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLP 248
+ L++ SN L+++ I + L+ N + + P L + SLELL L N ++ LP
Sbjct: 200 VRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
Query: 249 SELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFGYLKDKK 299
C L+ K LH+ N + E ++ +L L+D K
Sbjct: 260 E--FPSCSLL--------KELHVGENQIEMLEAEHLKHLNSILVLDLRDNK 300
Score = 65.1 bits (157), Expect = 7e-11
Identities = 55/227 (24%), Positives = 102/227 (44%), Gaps = 35/227 (15%)
Query: 76 LNLSHNQLRVLPPEVGKLTR---IVVLNLCGNRLKSLP-REVSLLQCLKVLFVNMNCLTE 131
L+ S Q ++P EV + + +N N+L +P R V L + + + ++ N L+
Sbjct: 404 LDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSF 463
Query: 132 VPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFL 191
+ EL + +KL L L +N L+ LP L RL+ +NLS N F +P ++ + L +
Sbjct: 464 ISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETI 523
Query: 192 HVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL 251
+ +N++ ++ P+ + ++ +L L+L NND+ +P EL
Sbjct: 524 LISNNQVGSVD----------------------PQKMKMMENLTTLDLQNNDLLQIPPEL 561
Query: 252 HLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFGYLKDK 298
L + L + NP P ++ G + YL+D+
Sbjct: 562 GNCVNL---------RTLLLDGNPFRVPRAAILMKGTAAILEYLRDR 599
Score = 45.8 bits (107), Expect = 5e-05
Identities = 36/122 (29%), Positives = 60/122 (49%), Gaps = 2/122 (1%)
Query: 60 MTDIPDFLWGLSE-VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQC 118
+ +IP + L E V ++LS N+L + E+ L ++ L+L N L SLP E+ L
Sbjct: 437 LCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVR 496
Query: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQL-PACFADLSRLRKLNLSNNFFAH 177
L+ + ++ N +P L LE + +S+N + + P + L L+L NN
Sbjct: 497 LQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQ 556
Query: 178 IP 179
IP
Sbjct: 557 IP 558
Score = 28.5 bits (62), Expect = 7.6
Identities = 15/48 (31%), Positives = 26/48 (54%), Gaps = 1/48 (2%)
Query: 70 LSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQ 117
+ + L+L +N L +PPE+G + L L GN + +PR L++
Sbjct: 541 MENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFR-VPRAAILMK 587
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 106 bits (264), Expect = 3e-23
Identities = 65/180 (36%), Positives = 99/180 (55%), Gaps = 1/180 (0%)
Query: 73 VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEV 132
+ KLN+ NQL LP + G T +V LNL N+L +P +VS L L+VL ++ N L ++
Sbjct: 381 LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL 440
Query: 133 PAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLH 192
P L RKL L L N L LP A L L+KL L+NN +P + L L L
Sbjct: 441 PHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLG 500
Query: 193 VGSNRLENIAESIQHLASL-QIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL 251
+G N L ++ E I L +L ++++ + N+HS P L L + L ++++ N + LP ++
Sbjct: 501 LGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560
Score = 102 bits (254), Expect = 4e-22
Identities = 65/206 (31%), Positives = 110/206 (53%), Gaps = 2/206 (0%)
Query: 55 LVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVS 114
L + + +P + L + L LS N L LP + L ++ +L+L N+L+ +P V
Sbjct: 130 LYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVY 189
Query: 115 LLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNF 174
L L L++ N +T V ++ KL +LS+ N + QLPA +L L L++++N
Sbjct: 190 RLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQ 249
Query: 175 FAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSL 234
H+P + + ++ L + N L ++ ++I +L+SL N + + PRSL ++L
Sbjct: 250 LEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSAL 309
Query: 235 ELLNLNNNDIQTLPSELHLLCRLVRI 260
E LNL NN+I TLP LL LV++
Sbjct: 310 EELNLENNNISTLPES--LLSSLVKL 333
Score = 93.2 bits (230), Expect = 3e-19
Identities = 59/199 (29%), Positives = 102/199 (51%), Gaps = 1/199 (0%)
Query: 51 VSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLP 110
++ +L +T +PD L L +++ L+L HN+LR +P V +L + L L NR+ ++
Sbjct: 149 MTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVE 208
Query: 111 REVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNL 170
+++ L L +L + N + ++PAE+ L L ++HN L LP + +++ L+L
Sbjct: 209 KDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDL 268
Query: 171 SNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRS-LC 229
+N +P + +L L L + NRL I S+ ++L+ E NNI + P S L
Sbjct: 269 QHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLS 328
Query: 230 LVTSLELLNLNNNDIQTLP 248
+ L L L N Q P
Sbjct: 329 SLVKLNSLTLARNCFQLYP 347
Score = 84.3 bits (207), Expect = 1e-16
Identities = 75/301 (24%), Positives = 124/301 (41%), Gaps = 64/301 (21%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREV-SLLQC 118
+ D+PD + LS + +L L +N+L +P + K + + LNL N + +LP + S L
Sbjct: 273 LLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVK 332
Query: 119 LKVLFVNMNC------------------------------------------------LT 130
L L + NC LT
Sbjct: 333 LNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLT 392
Query: 131 EVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIF 190
+P + + L+L+ N L+++P + L L L LSNN +P + +L++L
Sbjct: 393 SLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRE 452
Query: 191 LHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSE 250
L + N+LE++ I +L LQ + N + + PR + +T+L L L N + LP E
Sbjct: 453 LDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEE 512
Query: 251 LHLLCRLVRIAWN--------PMDKGL-------HISHNPLSKPLPELVEGGLEMLFGYL 295
+ L L + N P + L I + PLS P++V GG + +L
Sbjct: 513 IGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFL 572
Query: 296 K 296
K
Sbjct: 573 K 573
Score = 31.2 bits (69), Expect = 1.2
Identities = 16/42 (38%), Positives = 26/42 (61%)
Query: 220 NIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIA 261
+IH P S+ +T L L L +N +Q+LP+E+ L L+ +A
Sbjct: 111 SIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLA 152
>gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
Length = 277
Score = 105 bits (263), Expect = 4e-23
Identities = 71/211 (33%), Positives = 115/211 (54%), Gaps = 5/211 (2%)
Query: 38 RDPRSLLKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIV 97
RD R + M +S S + R P + E+ KL LS N L LPPE+G+L +
Sbjct: 23 RDLREMPLDKMVDLSGSQLRR----FPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQ 78
Query: 98 VLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPA 157
+L L N K+LP+ V L+ L +L++ N L ++P+ELSL + L L + NCL+QLP
Sbjct: 79 ILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPD 138
Query: 158 CFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAE 217
+LS L+ L+ +N +P + L+EL + + NRL + + H+ L++ +
Sbjct: 139 VVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVD 198
Query: 218 GNNIHSFPRSLCLVTSLELLNLNNNDIQTLP 248
N+I FP SL ++SL+L+ ++N + P
Sbjct: 199 WNSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
Score = 65.9 bits (159), Expect = 4e-11
Identities = 48/174 (27%), Positives = 89/174 (51%), Gaps = 2/174 (1%)
Query: 90 VGKLTRIVVLNLCGNRLKS-LPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLS 148
+G R +V + +R ++ + R++ + K++ ++ + L P + R+L L LS
Sbjct: 1 MGNTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLS 60
Query: 149 HNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHL 208
N L+ LP L L+ L L N F +P V +LK+L L++G+N+L ++ + L
Sbjct: 61 DNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLL 120
Query: 209 ASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAW 262
+L+ E N + P +C ++ L+ L+ +N ++ LP +L L L R W
Sbjct: 121 QNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQEL-RTIW 173
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 105 bits (261), Expect = 6e-23
Identities = 68/240 (28%), Positives = 126/240 (52%), Gaps = 3/240 (1%)
Query: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVL 122
+P L L+++Q+ L L +P +G+ ++VL+L N + +P + LL L+ L
Sbjct: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
Query: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNC-LSQLPACFADLSRLRKLNLSNNFFAHIPMC 181
++ N + VP ELS C LE L L+ N + LP ++L +L L+LS N F IP+
Sbjct: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLA 194
Query: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNN 241
V ++ L +L +GSN+LE + ++I+ + +L + N I P+++ + +L L L+N
Sbjct: 195 VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSN 254
Query: 242 NDIQTLPSELHLLC--RLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFGYLKDKK 299
N +Q +P + + R V NP+ + + + + E GL+ + Y+++ +
Sbjct: 255 NKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQESR 314
Score = 64.3 bits (155), Expect = 1e-10
Identities = 36/118 (30%), Positives = 63/118 (53%)
Query: 56 VTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSL 115
V R + D+P L L ++ L+LS N +P V + + L++ N+L+ LP +
Sbjct: 161 VNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIER 220
Query: 116 LQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNN 173
+Q L L++ N +T +P +S + L L LS+N L +P C +++ LR +N +N
Sbjct: 221 MQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDN 278
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 102 bits (255), Expect = 3e-22
Identities = 64/202 (31%), Positives = 102/202 (50%), Gaps = 1/202 (0%)
Query: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVL 122
+PD L L +++L L NQL LPPE+G L R+V L++ NRL+ LP E+ L L L
Sbjct: 189 LPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDL 248
Query: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCV 182
++ N L +P + ++L +L + N L ++ D L +L L+ N +P +
Sbjct: 249 LLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSL 308
Query: 183 FSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNN 242
L +L L+V N LE + I +L + N + P L T L +L++ N
Sbjct: 309 GKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGN 368
Query: 243 DIQTLPSEL-HLLCRLVRIAWN 263
+Q+LP L HL + + +A N
Sbjct: 369 RLQSLPFALTHLNLKALWLAEN 390
Score = 101 bits (251), Expect = 9e-22
Identities = 68/206 (33%), Positives = 108/206 (52%), Gaps = 2/206 (0%)
Query: 46 RGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNR 105
R + H++ + V+ + +P + L+ + L L N L+ LP + L ++ L+L GN
Sbjct: 128 RSLAHLALNDVS--LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGND 185
Query: 106 LKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRL 165
L+ LP + L L+ L+++ N L+ +P EL R+L L +S N L +LPA L L
Sbjct: 186 LEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLL 245
Query: 166 RKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFP 225
L LS N +P + LK+L L V NRL + E+I +L I N + + P
Sbjct: 246 TDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALP 305
Query: 226 RSLCLVTSLELLNLNNNDIQTLPSEL 251
RSL +T L LN++ N ++ LP E+
Sbjct: 306 RSLGKLTKLTNLNVDRNHLEALPPEI 331
Score = 95.5 bits (236), Expect = 5e-20
Identities = 74/230 (32%), Positives = 114/230 (49%), Gaps = 12/230 (5%)
Query: 63 IPDFLWGLSE-VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKV 121
+P+ ++ S +++L L NQLR LP +L + L L N ++ LP EV+ L
Sbjct: 27 VPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVE 86
Query: 122 LFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMC 181
L V+ N + E+P + C+ LE+ S N LS+LP F L L L L++ +P
Sbjct: 87 LDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGD 146
Query: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNN 241
V +L L+ L + N L+++ S+ L L+ GN++ P +L + +L L L+
Sbjct: 147 VGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDR 206
Query: 242 NDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEML 291
N + LP EL L RLV L +S N L + EL GGL +L
Sbjct: 207 NQLSALPPELGNLRRLV---------CLDVSENRLEELPAEL--GGLVLL 245
Score = 82.0 bits (201), Expect = 6e-16
Identities = 57/188 (30%), Positives = 88/188 (46%), Gaps = 1/188 (0%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
++ +P L L + L++S N+L LP E+G L + L L N L+ LP + L+ L
Sbjct: 209 LSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQL 268
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
+L V+ N L EV + C L L L+ N L LP L++L LN+ N +P
Sbjct: 269 SILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALP 328
Query: 180 MCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNL 239
+ L L + NRL + + H L + GN + S P +L + +L+ L L
Sbjct: 329 PEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWL 387
Query: 240 NNNDIQTL 247
N Q +
Sbjct: 388 AENQAQPM 395
Score = 72.8 bits (177), Expect = 4e-13
Identities = 56/195 (28%), Positives = 87/195 (44%)
Query: 48 MHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLK 107
M V + + +IP+ + ++ + S N L LP +L + L L L+
Sbjct: 82 MQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQ 141
Query: 108 SLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRK 167
+LP +V L L L + N L +PA LS KLE L L N L LP L LR+
Sbjct: 142 ALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRE 201
Query: 168 LNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRS 227
L L N + +P + +L+ L+ L V NRLE + + L L + N + P
Sbjct: 202 LWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDG 261
Query: 228 LCLVTSLELLNLNNN 242
+ + L +L ++ N
Sbjct: 262 IGQLKQLSILKVDQN 276
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 102 bits (255), Expect = 3e-22
Identities = 64/202 (31%), Positives = 102/202 (50%), Gaps = 1/202 (0%)
Query: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVL 122
+PD L L +++L L NQL LPPE+G L R+V L++ NRL+ LP E+ L L L
Sbjct: 189 LPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDL 248
Query: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCV 182
++ N L +P + ++L +L + N L ++ D L +L L+ N +P +
Sbjct: 249 LLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSL 308
Query: 183 FSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNN 242
L +L L+V N LE + I +L + N + P L T L +L++ N
Sbjct: 309 GKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGN 368
Query: 243 DIQTLPSEL-HLLCRLVRIAWN 263
+Q+LP L HL + + +A N
Sbjct: 369 RLQSLPFALTHLNLKALWLAEN 390
Score = 101 bits (251), Expect = 9e-22
Identities = 68/206 (33%), Positives = 108/206 (52%), Gaps = 2/206 (0%)
Query: 46 RGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNR 105
R + H++ + V+ + +P + L+ + L L N L+ LP + L ++ L+L GN
Sbjct: 128 RSLAHLALNDVS--LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGND 185
Query: 106 LKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRL 165
L+ LP + L L+ L+++ N L+ +P EL R+L L +S N L +LPA L L
Sbjct: 186 LEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLL 245
Query: 166 RKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFP 225
L LS N +P + LK+L L V NRL + E+I +L I N + + P
Sbjct: 246 TDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALP 305
Query: 226 RSLCLVTSLELLNLNNNDIQTLPSEL 251
RSL +T L LN++ N ++ LP E+
Sbjct: 306 RSLGKLTKLTNLNVDRNHLEALPPEI 331
Score = 95.5 bits (236), Expect = 5e-20
Identities = 74/230 (32%), Positives = 114/230 (49%), Gaps = 12/230 (5%)
Query: 63 IPDFLWGLSE-VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKV 121
+P+ ++ S +++L L NQLR LP +L + L L N ++ LP EV+ L
Sbjct: 27 VPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVE 86
Query: 122 LFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMC 181
L V+ N + E+P + C+ LE+ S N LS+LP F L L L L++ +P
Sbjct: 87 LDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGD 146
Query: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNN 241
V +L L+ L + N L+++ S+ L L+ GN++ P +L + +L L L+
Sbjct: 147 VGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDR 206
Query: 242 NDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEML 291
N + LP EL L RLV L +S N L + EL GGL +L
Sbjct: 207 NQLSALPPELGNLRRLV---------CLDVSENRLEELPAEL--GGLVLL 245
Score = 82.0 bits (201), Expect = 6e-16
Identities = 57/188 (30%), Positives = 88/188 (46%), Gaps = 1/188 (0%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
++ +P L L + L++S N+L LP E+G L + L L N L+ LP + L+ L
Sbjct: 209 LSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQL 268
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
+L V+ N L EV + C L L L+ N L LP L++L LN+ N +P
Sbjct: 269 SILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALP 328
Query: 180 MCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNL 239
+ L L + NRL + + H L + GN + S P +L + +L+ L L
Sbjct: 329 PEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWL 387
Query: 240 NNNDIQTL 247
N Q +
Sbjct: 388 AENQAQPM 395
Score = 72.8 bits (177), Expect = 4e-13
Identities = 56/195 (28%), Positives = 87/195 (44%)
Query: 48 MHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLK 107
M V + + +IP+ + ++ + S N L LP +L + L L L+
Sbjct: 82 MQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQ 141
Query: 108 SLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRK 167
+LP +V L L L + N L +PA LS KLE L L N L LP L LR+
Sbjct: 142 ALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRE 201
Query: 168 LNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRS 227
L L N + +P + +L+ L+ L V NRLE + + L L + N + P
Sbjct: 202 LWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDG 261
Query: 228 LCLVTSLELLNLNNN 242
+ + L +L ++ N
Sbjct: 262 IGQLKQLSILKVDQN 276
>gi|190014581 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 102 bits (253), Expect = 5e-22
Identities = 72/264 (27%), Positives = 130/264 (49%), Gaps = 5/264 (1%)
Query: 40 PRSLLKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVL 99
P+ KR V F L T++PD L + +++ +S+ ++++P + + +L
Sbjct: 91 PKDRGKRSSAFV-FELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
Query: 100 NLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNC-LSQLPAC 158
+L N++ LP E+ L+ LK L V N L +P EL C LE L S N L +LP
Sbjct: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
Query: 159 FADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEG 218
++L ++ +++S N F+ +P+CV + L +L + SN L ++ + I L LQ F+
Sbjct: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
Query: 219 NNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL---HLLCRLVRIAWNPMDKGLHISHNP 275
N + P S+ + L LL ++ + + LP+ L + V + NP+D N
Sbjct: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGNE 329
Query: 276 LSKPLPELVEGGLEMLFGYLKDKK 299
+ + + E++ Y++D K
Sbjct: 330 IMESERDRQHFDKEVMKAYIEDLK 353
Score = 30.0 bits (66), Expect = 2.6
Identities = 26/120 (21%), Positives = 51/120 (42%), Gaps = 2/120 (1%)
Query: 132 VPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFL 191
+ + L K+E +L+ S LP S LS + +P + L
Sbjct: 69 IDTSVRLLDKIERNTLTRQ--SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREW 126
Query: 192 HVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL 251
++ + ++ I IQ +++I N I P + + +L+ LN+ N ++++P EL
Sbjct: 127 YISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPEL 186
>gi|27545328 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 102 bits (253), Expect = 5e-22
Identities = 72/264 (27%), Positives = 130/264 (49%), Gaps = 5/264 (1%)
Query: 40 PRSLLKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVL 99
P+ KR V F L T++PD L + +++ +S+ ++++P + + +L
Sbjct: 91 PKDRGKRSSAFV-FELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
Query: 100 NLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNC-LSQLPAC 158
+L N++ LP E+ L+ LK L V N L +P EL C LE L S N L +LP
Sbjct: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
Query: 159 FADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEG 218
++L ++ +++S N F+ +P+CV + L +L + SN L ++ + I L LQ F+
Sbjct: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
Query: 219 NNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL---HLLCRLVRIAWNPMDKGLHISHNP 275
N + P S+ + L LL ++ + + LP+ L + V + NP+D N
Sbjct: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGNE 329
Query: 276 LSKPLPELVEGGLEMLFGYLKDKK 299
+ + + E++ Y++D K
Sbjct: 330 IMESERDRQHFDKEVMKAYIEDLK 353
Score = 30.0 bits (66), Expect = 2.6
Identities = 26/120 (21%), Positives = 51/120 (42%), Gaps = 2/120 (1%)
Query: 132 VPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFL 191
+ + L K+E +L+ S LP S LS + +P + L
Sbjct: 69 IDTSVRLLDKIERNTLTRQ--SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREW 126
Query: 192 HVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL 251
++ + ++ I IQ +++I N I P + + +L+ LN+ N ++++P EL
Sbjct: 127 YISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPEL 186
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 101 bits (251), Expect = 9e-22
Identities = 59/210 (28%), Positives = 107/210 (50%)
Query: 51 VSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLP 110
+S L ++ +P + L ++ L + HN+L L E+ +L +I L L N+L+ +
Sbjct: 306 ISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365
Query: 111 REVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNL 170
++ + L++L ++ N L +P ++S C LE LSLS N L++LP L+ LRKL++
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425
Query: 171 SNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCL 230
+ N I C+ L + L N + ++ I++ + N I FP LC
Sbjct: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA 485
Query: 231 VTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
+ SL L++N N I +P ++ +L+ +
Sbjct: 486 LDSLYYLSVNGNYISEIPVDISFSKQLLHL 515
Score = 95.9 bits (237), Expect = 4e-20
Identities = 67/248 (27%), Positives = 116/248 (46%), Gaps = 32/248 (12%)
Query: 54 SLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRI----------------- 96
SL G++ +P + L ++ LN+SHN + +P E+ +L I
Sbjct: 194 SLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDL 253
Query: 97 ------VVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHN 150
+L+L N+L+ +P + L+ L+VL + N LT P L KL L L+ N
Sbjct: 254 ECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGN 313
Query: 151 CLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLAS 210
+S LP +L L L + +N + + +F L ++ L + N+LE I+ I++
Sbjct: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373
Query: 211 LQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAWNPMDKGLH 270
L+I I + N + + P + LE L+L++N + LP +H L L + LH
Sbjct: 374 LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL---------RKLH 424
Query: 271 ISHNPLSK 278
++ N + K
Sbjct: 425 VNRNNMVK 432
Score = 94.0 bits (232), Expect = 1e-19
Identities = 55/183 (30%), Positives = 100/183 (54%), Gaps = 1/183 (0%)
Query: 76 LNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLP-REVSLLQCLKVLFVNMNCLTEVPA 134
+NL L+ P ++ K+ + L L N++K+ + L L++L + N L+ +P+
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
Query: 135 ELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVG 194
E+ L L +L++SHN +S +P + L +R+L NN+ + P + L L L +G
Sbjct: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLG 265
Query: 195 SNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLL 254
N+L +I +++ L +L++ E N + +FP++LC + L L+L N I +LP E+ L
Sbjct: 266 KNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIREL 325
Query: 255 CRL 257
L
Sbjct: 326 KNL 328
Score = 90.1 bits (222), Expect = 2e-18
Identities = 56/215 (26%), Positives = 110/215 (51%), Gaps = 23/215 (10%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
+ +IP+ + + ++ L+LS N+L LP + KL + L++ N + + +S L +
Sbjct: 384 LKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNI 443
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
L + N +T+VP E+ C+K+ + LS+N + P L L L+++ N+ + IP
Sbjct: 444 CSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503
Query: 180 MCVFSLKELI-----------------------FLHVGSNRLENIAESIQHLASLQIFIA 216
+ + K+L+ +L +G N+++ I SI ++ SL + I
Sbjct: 504 VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLIL 563
Query: 217 EGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL 251
N +FPR LC + +L++L+L+ N +Q + S++
Sbjct: 564 CCNKFETFPRELCTLENLQVLDLSENQLQKISSDI 598
Score = 90.1 bits (222), Expect = 2e-18
Identities = 59/220 (26%), Positives = 110/220 (50%), Gaps = 12/220 (5%)
Query: 70 LSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCL 129
L ++ L+L NQ++ +P + + + VL LC N+ ++ PRE+ L+ L+VL ++ N L
Sbjct: 532 LINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQL 591
Query: 130 TEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSN---NFFAHIPMCVFSLK 186
++ +++ + ++ L+ S N P L L +LN+S +P + ++
Sbjct: 592 QKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMT 651
Query: 187 ELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQT 246
+L L + +N + I +I L +L A N I P SL + L+ LNL+ N++
Sbjct: 652 QLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTA 711
Query: 247 LPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEG 286
LPS ++ + L K ++ NPL +P E+ +G
Sbjct: 712 LPSAIYNIFSL---------KEINFDDNPLLRPPVEICKG 742
Score = 76.6 bits (187), Expect = 2e-14
Identities = 59/220 (26%), Positives = 103/220 (46%), Gaps = 12/220 (5%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
+TD+P + ++ K+ LS+N++ P + L + L++ GN + +P ++S + L
Sbjct: 453 ITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQL 512
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
L ++ N L L+ L L N + ++PA +++ L L L N F P
Sbjct: 513 LHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFP 572
Query: 180 MCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNL 239
+ +L+ L L + N+L+ I+ I +L +Q N FP LC + SLE LN+
Sbjct: 573 RELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNI 632
Query: 240 N---NNDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPL 276
+ + LP EL + +L K L IS+N +
Sbjct: 633 SQIKGRKLTRLPGELSNMTQL---------KELDISNNAI 663
Score = 74.3 bits (181), Expect = 1e-13
Identities = 50/169 (29%), Positives = 86/169 (50%), Gaps = 3/169 (1%)
Query: 64 PDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLF 123
P L L +Q L+LS NQL+ + ++ L I LN N+ P E+ LQ L+ L
Sbjct: 572 PRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLN 631
Query: 124 VNM---NCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPM 180
++ LT +P ELS +L+ L +S+N + ++P +L L L+ NN +++P
Sbjct: 632 ISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPP 691
Query: 181 CVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLC 229
+ SL +L L++ N L + +I ++ SL+ + N + P +C
Sbjct: 692 SLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC 740
Score = 58.5 bits (140), Expect = 7e-09
Identities = 44/167 (26%), Positives = 82/167 (49%), Gaps = 9/167 (5%)
Query: 46 RGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSH---NQLRVLPPEVGKLTRIVVLNLC 102
+G+ ++FS + P L L +++LN+S +L LP E+ +T++ L++
Sbjct: 602 KGIQKLNFS--SNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDIS 659
Query: 103 GNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADL 162
N ++ +PR + L+ L L N ++ +P L L+ L+LS N L+ LP+ ++
Sbjct: 660 NNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNI 719
Query: 163 SRLRKLNLSNNFFAHIPMCVFSLKELI----FLHVGSNRLENIAESI 205
L+++N +N P+ + K+L +L R E I E I
Sbjct: 720 FSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKI 766
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 100 bits (249), Expect = 2e-21
Identities = 59/193 (30%), Positives = 98/193 (50%)
Query: 62 DIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKV 121
++P+ + L ++ L L NQL LP E+G L ++ L++ NRL+ LP E+S L L
Sbjct: 188 NLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTD 247
Query: 122 LFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMC 181
L ++ N L +P + +KL +L + N L+QLP + L +L L+ N +P
Sbjct: 248 LVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKS 307
Query: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNN 241
+ LK+L L+ N+L ++ + I SL +F N + P + T L +L++
Sbjct: 308 IGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAG 367
Query: 242 NDIQTLPSELHLL 254
N + LP L L
Sbjct: 368 NRLLHLPLSLTAL 380
Score = 99.0 bits (245), Expect = 5e-21
Identities = 56/198 (28%), Positives = 104/198 (52%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
+ ++P+ + L +++KL LS N+++ LPPE+ ++V L++ N + +P +S + L
Sbjct: 48 LRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKAL 107
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
+V + N LT +P + L LS++ L LP +L L L L N ++P
Sbjct: 108 QVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLP 167
Query: 180 MCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNL 239
+ L+ L L +G+N + N+ ESI L L+ +GN + P+ + + +L L++
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227
Query: 240 NNNDIQTLPSELHLLCRL 257
+ N ++ LP E+ L L
Sbjct: 228 SENRLERLPEEISGLTSL 245
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/198 (30%), Positives = 100/198 (50%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
+ +P+ + L + L L N L LP + +L R+ L+L N + +LP + L L
Sbjct: 140 LQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHL 199
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
K L+++ N L+E+P E+ + L L +S N L +LP + L+ L L +S N IP
Sbjct: 200 KDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIP 259
Query: 180 MCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNL 239
+ LK+L L V NRL + E++ SL + N + + P+S+ + L LN
Sbjct: 260 DGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNA 319
Query: 240 NNNDIQTLPSELHLLCRL 257
+ N + +LP E+ C L
Sbjct: 320 DRNKLVSLPKEIGGCCSL 337
Score = 91.7 bits (226), Expect = 7e-19
Identities = 65/218 (29%), Positives = 109/218 (50%), Gaps = 18/218 (8%)
Query: 73 VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEV 132
+++L L NQLR LP + +L ++ L L N ++ LP E++ L L V+ N + E+
Sbjct: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEI 97
Query: 133 PAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLH 192
P +S C+ L+V S N L++LP F +L L L++++ +P + +L L L
Sbjct: 98 PESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLE 157
Query: 193 VGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL- 251
+ N L + +S+ L L+ N I++ P S+ + L+ L L+ N + LP E+
Sbjct: 158 LRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG 217
Query: 252 ---HLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEG 286
+LLC L +S N L + LPE + G
Sbjct: 218 NLKNLLC-------------LDVSENRLER-LPEEISG 241
Score = 87.4 bits (215), Expect = 1e-17
Identities = 59/201 (29%), Positives = 94/201 (46%)
Query: 48 MHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLK 107
M V + + +IP+ + +Q + S N L LP +L + L++ L+
Sbjct: 82 MQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQ 141
Query: 108 SLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRK 167
SLP + L L L + N LT +P L+ R+LE L L +N + LP L L+
Sbjct: 142 SLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKD 201
Query: 168 LNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRS 227
L L N + +P + +LK L+ L V NRLE + E I L SL + N + + P
Sbjct: 202 LWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDG 261
Query: 228 LCLVTSLELLNLNNNDIQTLP 248
+ + L +L ++ N + LP
Sbjct: 262 IGKLKKLSILKVDQNRLTQLP 282
Score = 68.2 bits (165), Expect = 9e-12
Identities = 45/133 (33%), Positives = 67/133 (50%), Gaps = 1/133 (0%)
Query: 129 LTEVPAEL-SLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKE 187
L VP E+ R LE L L N L +LP F L +LRKL LS+N +P + + +
Sbjct: 24 LVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQ 83
Query: 188 LIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTL 247
L+ L V N + I ESI +LQ+ GN + P S + +L L++N+ +Q+L
Sbjct: 84 LVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSL 143
Query: 248 PSELHLLCRLVRI 260
P + L L +
Sbjct: 144 PENIGNLYNLASL 156
Score = 65.9 bits (159), Expect = 4e-11
Identities = 44/158 (27%), Positives = 73/158 (46%)
Query: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVL 122
+P+ + GL+ + L +S N L +P +GKL ++ +L + NRL LP V + L L
Sbjct: 235 LPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTEL 294
Query: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCV 182
+ N L +P + +KL L+ N L LP L + +N IP V
Sbjct: 295 VLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEV 354
Query: 183 FSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNN 220
EL L V NRL ++ S+ L +++++ +
Sbjct: 355 SQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQS 392
Score = 45.4 bits (106), Expect = 6e-05
Identities = 33/96 (34%), Positives = 46/96 (47%), Gaps = 1/96 (1%)
Query: 55 LVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVS 114
L + +P + L ++ LN N+L LP E+G + V + NRL +P EVS
Sbjct: 296 LTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVS 355
Query: 115 LLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHN 150
L VL V N L +P L+ KL+ L LS N
Sbjct: 356 QATELHVLDVAGNRLLHLPLSLT-ALKLKALWLSDN 390
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 99.4 bits (246), Expect = 4e-21
Identities = 64/199 (32%), Positives = 107/199 (53%), Gaps = 2/199 (1%)
Query: 86 LPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVL 145
LP + L + L+L N L++LP V ++ L L ++ NCL+E+P L L L
Sbjct: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
Query: 146 SLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESI 205
+++HN L LP LS L++L+LS N +P + L L+ L++ SNRL+++ S+
Sbjct: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASL 236
Query: 206 QHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAWNPM 265
L SL++ + N + S P L + L L+L +N ++ LP EL L VR+ NP+
Sbjct: 237 AGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL-LDAPFVRLQGNPL 295
Query: 266 -DKGLHISHNPLSKPLPEL 283
+ +P++ +PE+
Sbjct: 296 GEASPDAPSSPVAALIPEM 314
Score = 74.3 bits (181), Expect = 1e-13
Identities = 46/117 (39%), Positives = 67/117 (57%), Gaps = 1/117 (0%)
Query: 51 VSFSLVTRG-MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSL 109
++F VT + +P L LS +Q+L+LS N L LPPE+G L ++ LNL NRL+SL
Sbjct: 173 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSL 232
Query: 110 PREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLR 166
P ++ L+ L++L ++ N L VPA+L+ L L L N L LP D +R
Sbjct: 233 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR 289
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 99.4 bits (246), Expect = 4e-21
Identities = 64/199 (32%), Positives = 107/199 (53%), Gaps = 2/199 (1%)
Query: 86 LPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVL 145
LP + L + L+L N L++LP V ++ L L ++ NCL+E+P L L L
Sbjct: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
Query: 146 SLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESI 205
+++HN L LP LS L++L+LS N +P + L L+ L++ SNRL+++ S+
Sbjct: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASL 236
Query: 206 QHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAWNPM 265
L SL++ + N + S P L + L L+L +N ++ LP EL L VR+ NP+
Sbjct: 237 AGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL-LDAPFVRLQGNPL 295
Query: 266 -DKGLHISHNPLSKPLPEL 283
+ +P++ +PE+
Sbjct: 296 GEASPDAPSSPVAALIPEM 314
Score = 74.3 bits (181), Expect = 1e-13
Identities = 46/117 (39%), Positives = 67/117 (57%), Gaps = 1/117 (0%)
Query: 51 VSFSLVTRG-MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSL 109
++F VT + +P L LS +Q+L+LS N L LPPE+G L ++ LNL NRL+SL
Sbjct: 173 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSL 232
Query: 110 PREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLR 166
P ++ L+ L++L ++ N L VPA+L+ L L L N L LP D +R
Sbjct: 233 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR 289
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 98.2 bits (243), Expect = 8e-21
Identities = 73/247 (29%), Positives = 120/247 (48%), Gaps = 33/247 (13%)
Query: 58 RGMTDIPDF--LWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSL 115
RG++++ D L+ LS + +L LSHN+L ++PP + +L + VLN N+++ LP ++S
Sbjct: 25 RGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISS 84
Query: 116 LQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQ--LPACFADLSRLRKLNLSNN 173
LQ LK L + MN L +P LEVL L++N LS+ LP F L+ LR L LS+N
Sbjct: 85 LQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDN 144
Query: 174 FFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTS 233
F +P I L LQI N++ S P+ + +T
Sbjct: 145 DFEILP-----------------------PDIGKLTKLQILSLRDNDLISLPKEIGELTQ 181
Query: 234 LELLNLNNNDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFG 293
L+ L++ N + LP EL + + +NP P+ + + G+ +F
Sbjct: 182 LKELHIQGNRLTVLPPELG------NLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFE 235
Query: 294 YLKDKKH 300
Y++ + +
Sbjct: 236 YIRSETY 242
Score = 75.5 bits (184), Expect = 5e-14
Identities = 55/176 (31%), Positives = 84/176 (47%), Gaps = 5/176 (2%)
Query: 49 HHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKS 108
H L +T +P + L ++ LN +NQ+ LP ++ L ++ LNL NRL +
Sbjct: 41 HITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 100
Query: 109 LPREVSLLQCLKVLFVNMNCLTE--VPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLR 166
LPR L L+VL + N L+E +P L L LS N LP L++L+
Sbjct: 101 LPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQ 160
Query: 167 KLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHL---ASLQIFIAEGN 219
L+L +N +P + L +L LH+ NRL + + +L Q+F AE N
Sbjct: 161 ILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENN 216
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 93.6 bits (231), Expect = 2e-19
Identities = 65/194 (33%), Positives = 103/194 (53%), Gaps = 7/194 (3%)
Query: 75 KLNLSHNQLRVLPPEVGK-LTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCL---T 130
+L L HN+L LP +G + +L++ GN L +L E+ L+ L+ L N L +
Sbjct: 48 RLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPS 107
Query: 131 EVP---AELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKE 187
+P A+ LCR L+VL+LS NC ++PA +L L+ L+L N IP + +L+
Sbjct: 108 ALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQS 167
Query: 188 LIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTL 247
L L++G N ++ I + +L SL + N I S P L + SL L+L+NN + L
Sbjct: 168 LECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYL 227
Query: 248 PSELHLLCRLVRIA 261
P E+ L L ++
Sbjct: 228 PREILNLIHLEELS 241
Score = 82.4 bits (202), Expect = 4e-16
Identities = 69/226 (30%), Positives = 105/226 (46%), Gaps = 23/226 (10%)
Query: 69 GLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRL---KSLPREVS---LLQCLKVL 122
G +Q L++S N L L PE+ L + L NRL +LP+ ++ L + L+VL
Sbjct: 66 GFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVL 125
Query: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCV 182
++ NC EVPA L R L+ LSL N L +PA +L L L L NF IP +
Sbjct: 126 NLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPEL 185
Query: 183 FSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNN 242
+L L +L + N++++I + L SL+ N + PR + + LE L+L N
Sbjct: 186 GNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGN 245
Query: 243 DIQTL---------PSELHLLCRLVRIAWNPMDKGLHISHNPLSKP 279
+ P+ L L R ++I +IS+ P P
Sbjct: 246 PLVVRFVRDLTYDPPTLLELAARTIKIR--------NISYTPYDLP 283
Score = 75.1 bits (183), Expect = 7e-14
Identities = 52/165 (31%), Positives = 83/165 (50%), Gaps = 4/165 (2%)
Query: 34 LLSGRDPRSLLKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKL 93
LL+ R R+LL + S + +G+ P +Q LNLS N + +P + +L
Sbjct: 87 LLALRGLRTLLAKNNRLGGPSALPKGLAQSPL----CRSLQVLNLSGNCFQEVPASLLEL 142
Query: 94 TRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLS 153
+ L+L GN+L+S+P E+ LQ L+ L++ N + E+P EL L L L N +
Sbjct: 143 RALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQ 202
Query: 154 QLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRL 198
+P + L LR L+L NN ++P + +L L L + N L
Sbjct: 203 SIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
>gi|223005922 leucine rich repeat containing 10-like [Homo sapiens]
Length = 292
Score = 92.4 bits (228), Expect = 4e-19
Identities = 68/206 (33%), Positives = 100/206 (48%), Gaps = 10/206 (4%)
Query: 74 QKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVP 133
Q+L LS +LR LP V L+R+ L + G L+ LP E+ L+ L++L ++ N L +P
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Query: 134 AELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHV 193
L +L L L N L LPA FA L LR L + NF P + L L L +
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 194 GSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHL 253
G NRL + + + L+ GN FP +L + L +L+L+ N + P +LH
Sbjct: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DLHP 202
Query: 254 LCRLVRIAWNPMDKGLHISHNPLSKP 279
L R +R+ HNP++ P
Sbjct: 203 L-RALRV--------FSYDHNPVTGP 219
Score = 75.1 bits (183), Expect = 7e-14
Identities = 53/168 (31%), Positives = 84/168 (50%), Gaps = 1/168 (0%)
Query: 59 GMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQC 118
G+ ++P+ + L E++ L L N+L LP + +L R+ L L GNRL +LP + + LQ
Sbjct: 55 GLRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQS 114
Query: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHI 178
L+ L++ N L P L L+ L + N L LPA ++ LR L L N F
Sbjct: 115 LRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEF 174
Query: 179 PMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPR 226
P + + L L + NRL + + L +L++F + N + PR
Sbjct: 175 PPALLRMGRLHILDLDRNRLGGFPD-LHPLRALRVFSYDHNPVTGPPR 221
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 92.0 bits (227), Expect = 6e-19
Identities = 70/243 (28%), Positives = 111/243 (45%), Gaps = 29/243 (11%)
Query: 44 LKRGMHHVSFSLVTRGMTDIPDFLW-GLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLC 102
L+ + + +L + IP+ L+ L+++ L+LS N+L LPP++ +L + L L
Sbjct: 123 LENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLN 182
Query: 103 GNRL--------------------------KSLPREVSLLQCLKVLFVNMNCLTEVPAEL 136
GN L +LP + L L + ++ N LT VP L
Sbjct: 183 GNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECL 242
Query: 137 SLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSN 196
L L+LS N +++L C + LNLS N +P + L +L L++ SN
Sbjct: 243 YTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSN 302
Query: 197 RLE--NIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLL 254
+L+ + I L +L+ F+A NN+ P SLC L L LN N + TLP +H L
Sbjct: 303 KLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFL 362
Query: 255 CRL 257
+
Sbjct: 363 TEI 365
Score = 84.7 bits (208), Expect = 9e-17
Identities = 62/204 (30%), Positives = 102/204 (50%), Gaps = 6/204 (2%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVG-KLTRIVVLNLCGNRLKSLPREVSLLQC 118
+T+ P L + LNLSHN + +P ++ LT ++ L+L NRL+SLP ++ L
Sbjct: 116 LTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVH 175
Query: 119 LKVLFVNMNCLTEVPA-ELSLCRKLEVLSL--SHNCLSQLPACFADLSRLRKLNLSNNFF 175
L+ L +N N L +L L+ L L + S LP LS L ++LS N
Sbjct: 176 LQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDL 235
Query: 176 AHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLE 235
+P C+++L L L++ SN++ ++ I ++ N + S P ++C ++ L+
Sbjct: 236 TRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLK 295
Query: 236 LLNLNNN--DIQTLPSELHLLCRL 257
L LN+N D LPS + L L
Sbjct: 296 KLYLNSNKLDFDGLPSGIGKLTNL 319
Score = 79.3 bits (194), Expect = 4e-15
Identities = 60/207 (28%), Positives = 101/207 (48%), Gaps = 27/207 (13%)
Query: 59 GMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKS--LPREVSLL 116
G+ +P+ L L +++ L++SHN L L E+ L + + N LK+ +P ++ L
Sbjct: 44 GLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKL 103
Query: 117 QCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFA 176
L VL ++ N LTE P EL + + VL+LSHN + +P N F
Sbjct: 104 DDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIP---------------NQLF- 147
Query: 177 HIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNN-IHSFPRSLCLVTSLE 235
+L +L++L + NRLE++ ++ L LQ + GN +H+ R L +T+L+
Sbjct: 148 ------INLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQ 201
Query: 236 LLNLNNND--IQTLPSELHLLCRLVRI 260
L+L + LP+ L L L +
Sbjct: 202 TLHLRSTQRTQSNLPTSLEGLSNLADV 228
Score = 67.8 bits (164), Expect = 1e-11
Identities = 50/178 (28%), Positives = 87/178 (48%), Gaps = 5/178 (2%)
Query: 91 GKLTRIVVLNLCGNRLKS--LPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLS 148
G L + ++L GN K P V + L+ L +N L +P EL+ +KLE LS+S
Sbjct: 5 GVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVS 64
Query: 149 HNCLSQLPACFADLSRLRKLNLSNNFFAH--IPMCVFSLKELIFLHVGSNRLENIAESIQ 206
HN L+ L + L LR + N + +P +F L +L L + N+L ++
Sbjct: 65 HNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELE 124
Query: 207 HLASLQIFIAEGNNIHSFPRSLCL-VTSLELLNLNNNDIQTLPSELHLLCRLVRIAWN 263
+ ++ + N+I + P L + +T L L+L+ N +++LP ++ L L + N
Sbjct: 125 NAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLN 182
Score = 57.8 bits (138), Expect = 1e-08
Identities = 45/170 (26%), Positives = 76/170 (44%), Gaps = 26/170 (15%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
+T +P+ L+ L +++LNLS NQ+ L + + + LNL N+L SLP + L L
Sbjct: 235 LTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKL 294
Query: 120 KVLFVNMNCLT--EVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAH 177
K L++N N L +P+ + LE ++N L +P +LRKL L+ N
Sbjct: 295 KKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVT 354
Query: 178 IPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIF-IAEGNNIHSFPR 226
+P E+I L +++ + E N+ P+
Sbjct: 355 LP-----------------------EAIHFLTEIEVLDVRENPNLVMPPK 381
Score = 49.7 bits (117), Expect = 3e-06
Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 48 MHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRV--LPPEVGKLTRIVVLNLCGNR 105
+H + +L +T +P + LS+++KL L+ N+L LP +GKLT + N
Sbjct: 269 VHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNN 328
Query: 106 LKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFAD 161
L+ +P + L+ L +N N L +P + ++EVL + N +P AD
Sbjct: 329 LELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 92.0 bits (227), Expect = 6e-19
Identities = 55/209 (26%), Positives = 105/209 (50%), Gaps = 4/209 (1%)
Query: 44 LKRGMHHVS----FSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVL 99
L + MH ++ L ++P+ L + +++L + +N L+VLP +GKL +V L
Sbjct: 176 LPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYL 235
Query: 100 NLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACF 159
++ NR++++ ++S + L+ L ++ N L ++P + L +KL L + N L+ LP
Sbjct: 236 DMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 295
Query: 160 ADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGN 219
+LS L + + S N +P + L L L V N L + I ++ + N
Sbjct: 296 GNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSN 355
Query: 220 NIHSFPRSLCLVTSLELLNLNNNDIQTLP 248
+ P + + L +LNL++N ++ LP
Sbjct: 356 KLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
Score = 84.3 bits (207), Expect = 1e-16
Identities = 47/138 (34%), Positives = 74/138 (53%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
+ +PD + L ++ L + NQL +LP +G L+ + + N L+SLP + L L
Sbjct: 265 LQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSL 324
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
+ L V+ N L E+P E+ C+ + V+SL N L LP + +LR LNLS+N ++P
Sbjct: 325 RTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
Query: 180 MCVFSLKELIFLHVGSNR 197
LKEL L + N+
Sbjct: 385 FSFTKLKELAALWLSDNQ 402
Score = 84.0 bits (206), Expect = 2e-16
Identities = 52/195 (26%), Positives = 100/195 (51%)
Query: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVL 122
+P + L+++++L+L +N+ LP + ++ + L + N L+ LP + L+ L L
Sbjct: 176 LPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYL 235
Query: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCV 182
++ N + V ++S C LE L LS N L QLP L +L L + +N +P +
Sbjct: 236 DMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 295
Query: 183 FSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNN 242
+L L N LE++ +I +L SL+ + N + PR + ++ +++L +N
Sbjct: 296 GNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSN 355
Query: 243 DIQTLPSELHLLCRL 257
++ LP E+ + +L
Sbjct: 356 KLEFLPEEIGQMQKL 370
Score = 82.4 bits (202), Expect = 4e-16
Identities = 54/186 (29%), Positives = 92/186 (49%)
Query: 73 VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEV 132
+++L L NQ+ LP ++ + L++ N L +LP ++ L LK L ++ N + E
Sbjct: 48 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107
Query: 133 PAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLH 192
P + C+ L ++ S N +S+LP F L L +L L++ F +P L +L L
Sbjct: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILE 167
Query: 193 VGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELH 252
+ N L+ + +S+ LA L+ N P L + +L L ++NN +Q LP +
Sbjct: 168 LRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIG 227
Query: 253 LLCRLV 258
L LV
Sbjct: 228 KLKMLV 233
Score = 79.7 bits (195), Expect = 3e-15
Identities = 51/182 (28%), Positives = 90/182 (49%)
Query: 70 LSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCL 129
L +++ L L N L+ LP + KL ++ L+L N LP + +Q L+ L+++ N L
Sbjct: 160 LVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNAL 219
Query: 130 TEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELI 189
+P + + L L +S N + + + L L LS+N +P + LK+L
Sbjct: 220 QVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLT 279
Query: 190 FLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPS 249
L V N+L + +I +L+ L+ F N + S P ++ + SL L ++ N + LP
Sbjct: 280 TLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPR 339
Query: 250 EL 251
E+
Sbjct: 340 EI 341
Score = 79.3 bits (194), Expect = 4e-15
Identities = 56/202 (27%), Positives = 98/202 (48%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
++ +PD L + +L L+ L LP G+L ++ +L L N LK+LP+ + L L
Sbjct: 127 ISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQL 186
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
+ L + N E+P L + L L + +N L LP L L L++S N +
Sbjct: 187 ERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVD 246
Query: 180 MCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNL 239
M + + L L + SN L+ + +SI L L + N + P ++ ++ LE +
Sbjct: 247 MDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDC 306
Query: 240 NNNDIQTLPSELHLLCRLVRIA 261
+ N++++LPS + L L +A
Sbjct: 307 SCNELESLPSTIGYLHSLRTLA 328
Score = 78.6 bits (192), Expect = 6e-15
Identities = 46/190 (24%), Positives = 93/190 (48%)
Query: 62 DIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKV 121
++P L+ ++KL++ N L LP + L + L++ N ++ P + +CL +
Sbjct: 60 ELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI 119
Query: 122 LFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMC 181
+ ++N ++++P + L L L+ L LPA F L +LR L L N +P
Sbjct: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS 179
Query: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNN 241
+ L +L L +G+N + E + + +L+ + N + P S+ + L L+++
Sbjct: 180 MHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSK 239
Query: 242 NDIQTLPSEL 251
N I+T+ ++
Sbjct: 240 NRIETVDMDI 249
Score = 72.8 bits (177), Expect = 4e-13
Identities = 46/166 (27%), Positives = 80/166 (48%), Gaps = 1/166 (0%)
Query: 96 IVVLNLCGNRLKSLPREV-SLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQ 154
I VL+ L+ +P+EV + + L+ L+++ N + E+P +L C+ L LS+ N LS
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
Query: 155 LPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIF 214
LP A L L++L++S N P + K L + N + + + L +L
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
Query: 215 IAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
+ P + + L +L L N ++TLP +H L +L R+
Sbjct: 144 YLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERL 189
Score = 47.0 bits (110), Expect = 2e-05
Identities = 33/123 (26%), Positives = 54/123 (43%), Gaps = 1/123 (0%)
Query: 142 LEVLSLSHNCLSQLPACFADLSR-LRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLEN 200
+ VL SH L Q+P + R L +L L N +P +F+ + L L + N L N
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
Query: 201 IAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
+ +I L +L+ N + FP ++ L ++ + N I LP L L ++
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
Query: 261 AWN 263
N
Sbjct: 144 YLN 146
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 92.0 bits (227), Expect = 6e-19
Identities = 66/207 (31%), Positives = 106/207 (51%), Gaps = 1/207 (0%)
Query: 44 LKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCG 103
L G + +L + MT +P L L ++ L L +N + + PE+ LT++ LNL
Sbjct: 10 LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69
Query: 104 NRLKSLPREVSLLQCLKVLFVNMNCLTE-VPAELSLCRKLEVLSLSHNCLSQLPACFADL 162
N L+ +P E+ L LK L ++ N + P + L +L+L++N L+QLP + L
Sbjct: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRL 129
Query: 163 SRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIH 222
L ++++ N A IP + L+ L+ L + N+L I E I+ L LQ + NNI
Sbjct: 130 KSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIG 189
Query: 223 SFPRSLCLVTSLELLNLNNNDIQTLPS 249
P LC + L +L++ N IQ PS
Sbjct: 190 VLPEELCDLKKLRILDIAGNIIQIFPS 216
Score = 84.0 bits (206), Expect = 2e-16
Identities = 53/171 (30%), Positives = 86/171 (50%), Gaps = 3/171 (1%)
Query: 91 GKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHN 150
GK T+I+ LN G ++ +P + L LK L + N + +V EL +L L+L +N
Sbjct: 13 GKNTKIITLN--GKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNN 70
Query: 151 CLSQLPACFADLSRLRKLNLSNNFFAHI-PMCVFSLKELIFLHVGSNRLENIAESIQHLA 209
L ++P L+ L+ L+LS N P L+ LI L++ +N L + + + L
Sbjct: 71 LLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK 130
Query: 210 SLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
SL N + S PR LC + +L L LN N + +P E+ L +L ++
Sbjct: 131 SLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKL 181
Score = 78.6 bits (192), Expect = 6e-15
Identities = 52/161 (32%), Positives = 84/161 (52%), Gaps = 2/161 (1%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQL-RVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQC 118
+ ++P+ + L+ ++ L+LS N++ R P L +++LNL N L LP+EVS L+
Sbjct: 72 LEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKS 131
Query: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHI 178
L + +N N L +P EL L L L++N L +P L +L+KL L+ N +
Sbjct: 132 LTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVL 191
Query: 179 PMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGN 219
P + LK+L L + N ++ Q L L+ F EGN
Sbjct: 192 PEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGN 231
Score = 62.8 bits (151), Expect = 4e-10
Identities = 40/129 (31%), Positives = 70/129 (54%), Gaps = 1/129 (0%)
Query: 136 LSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGS 195
LS + ++++L+ ++++P+ L L+ L L NN + + +L +L L++G+
Sbjct: 10 LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69
Query: 196 NRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCL-VTSLELLNLNNNDIQTLPSELHLL 254
N LE + E +++L SL+ GN I F C + +L LLNLNNN + LP E+ L
Sbjct: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRL 129
Query: 255 CRLVRIAWN 263
L ++ N
Sbjct: 130 KSLTYMSIN 138
Score = 61.2 bits (147), Expect = 1e-09
Identities = 47/178 (26%), Positives = 89/178 (50%), Gaps = 11/178 (6%)
Query: 51 VSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLP 110
+ +L +T +P + L + +++++NQL +P E+ L +V L L N+L +P
Sbjct: 110 ILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIP 169
Query: 111 REVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNL 170
E+ L+ L+ L + N + +P EL +KL +L ++ N + P+ F DL +LR+
Sbjct: 170 EEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYC 228
Query: 171 SNN-FFAHIPMC------VFSLKELIFLHVGSNRLEN---IAESIQHLASLQIFIAEG 218
N F P+ V+SL+E+ V + EN + + I+ ++ I++G
Sbjct: 229 EGNPLFLQQPVISTQQENVWSLQEITSRFVMNQLAENNPFLMDDIERYPQVRSMISQG 286
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 91.7 bits (226), Expect = 7e-19
Identities = 60/212 (28%), Positives = 105/212 (49%), Gaps = 4/212 (1%)
Query: 44 LKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVG--KLTRIVVLNL 101
LK+ + L+ + IP ++ L +Q+++L N L+ + + L R+ L L
Sbjct: 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646
Query: 102 CGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFAD 161
N + +P ++ L L+ L++N N + ++P +L CRKL L LSHN L+ LPA
Sbjct: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 162 LSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNI 221
L L+ L ++ N +P +F ++L LH+G+N L+++ + L +L GN +
Sbjct: 707 LQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766
Query: 222 HSFPRSL--CLVTSLELLNLNNNDIQTLPSEL 251
P L C + L + + TLP E+
Sbjct: 767 ECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 66.6 bits (161), Expect = 3e-11
Identities = 57/233 (24%), Positives = 108/233 (46%), Gaps = 7/233 (3%)
Query: 35 LSGRDPRSLLKRGMHHVSFSLVTR---GMTDIPDFLWGLS-EVQKLNLSHNQLRVLP-PE 89
LS + R ++ G+ + V R ++ +P + + +QKL++++ +++
Sbjct: 527 LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNS 586
Query: 90 VGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSL--CRKLEVLSL 147
+ K+ + L L L+ +P + L L+ + + N L + +S +L L L
Sbjct: 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646
Query: 148 SHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQH 207
+N ++ +P +L+ L +L L+ N IP +F ++L +L + N L + I
Sbjct: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 208 LASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
L +LQ N I + P L L L+L NN +Q+LPS + L L +I
Sbjct: 707 LQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759
Score = 58.9 bits (141), Expect = 5e-09
Identities = 70/273 (25%), Positives = 109/273 (39%), Gaps = 64/273 (23%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLK-SLPREVSLLQC 118
++ IPD ++ L E++ L L +PP + +LT + L L K P L +
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494
Query: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNC--------------------------- 151
L+ L + + E+P + + LE L L+ N
Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554
Query: 152 LSQLPACFADLS-RLRKLNLSNN------------------------FFAHIPMCVFSLK 186
LS+LP D+ L+KL+++N IP +FSL
Sbjct: 555 LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLH 614
Query: 187 ELIFLHVGSNRLENIAE--SIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDI 244
L + + N L+ I E S QHL L N+I P + +T+LE L LN N I
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 245 QTLPSELHLLCRLVRIAWNPMDKGLHISHNPLS 277
+ +P++L CR +R L +SHN L+
Sbjct: 675 EKIPTQL-FYCRKLRY--------LDLSHNNLT 698
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 91.7 bits (226), Expect = 7e-19
Identities = 60/212 (28%), Positives = 105/212 (49%), Gaps = 4/212 (1%)
Query: 44 LKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVG--KLTRIVVLNL 101
LK+ + L+ + IP ++ L +Q+++L N L+ + + L R+ L L
Sbjct: 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646
Query: 102 CGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFAD 161
N + +P ++ L L+ L++N N + ++P +L CRKL L LSHN L+ LPA
Sbjct: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 162 LSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNI 221
L L+ L ++ N +P +F ++L LH+G+N L+++ + L +L GN +
Sbjct: 707 LQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766
Query: 222 HSFPRSL--CLVTSLELLNLNNNDIQTLPSEL 251
P L C + L + + TLP E+
Sbjct: 767 ECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 66.6 bits (161), Expect = 3e-11
Identities = 57/233 (24%), Positives = 108/233 (46%), Gaps = 7/233 (3%)
Query: 35 LSGRDPRSLLKRGMHHVSFSLVTR---GMTDIPDFLWGLS-EVQKLNLSHNQLRVLP-PE 89
LS + R ++ G+ + V R ++ +P + + +QKL++++ +++
Sbjct: 527 LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNS 586
Query: 90 VGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSL--CRKLEVLSL 147
+ K+ + L L L+ +P + L L+ + + N L + +S +L L L
Sbjct: 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646
Query: 148 SHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQH 207
+N ++ +P +L+ L +L L+ N IP +F ++L +L + N L + I
Sbjct: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 208 LASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
L +LQ N I + P L L L+L NN +Q+LPS + L L +I
Sbjct: 707 LQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759
Score = 58.9 bits (141), Expect = 5e-09
Identities = 70/273 (25%), Positives = 109/273 (39%), Gaps = 64/273 (23%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLK-SLPREVSLLQC 118
++ IPD ++ L E++ L L +PP + +LT + L L K P L +
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494
Query: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNC--------------------------- 151
L+ L + + E+P + + LE L L+ N
Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554
Query: 152 LSQLPACFADLS-RLRKLNLSNN------------------------FFAHIPMCVFSLK 186
LS+LP D+ L+KL+++N IP +FSL
Sbjct: 555 LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLH 614
Query: 187 ELIFLHVGSNRLENIAE--SIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDI 244
L + + N L+ I E S QHL L N+I P + +T+LE L LN N I
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 245 QTLPSELHLLCRLVRIAWNPMDKGLHISHNPLS 277
+ +P++L CR +R L +SHN L+
Sbjct: 675 EKIPTQL-FYCRKLRY--------LDLSHNNLT 698
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 91.7 bits (226), Expect = 7e-19
Identities = 60/212 (28%), Positives = 105/212 (49%), Gaps = 4/212 (1%)
Query: 44 LKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVG--KLTRIVVLNL 101
LK+ + L+ + IP ++ L +Q+++L N L+ + + L R+ L L
Sbjct: 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646
Query: 102 CGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFAD 161
N + +P ++ L L+ L++N N + ++P +L CRKL L LSHN L+ LPA
Sbjct: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 162 LSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNI 221
L L+ L ++ N +P +F ++L LH+G+N L+++ + L +L GN +
Sbjct: 707 LQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766
Query: 222 HSFPRSL--CLVTSLELLNLNNNDIQTLPSEL 251
P L C + L + + TLP E+
Sbjct: 767 ECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 66.6 bits (161), Expect = 3e-11
Identities = 57/233 (24%), Positives = 108/233 (46%), Gaps = 7/233 (3%)
Query: 35 LSGRDPRSLLKRGMHHVSFSLVTR---GMTDIPDFLWGLS-EVQKLNLSHNQLRVLP-PE 89
LS + R ++ G+ + V R ++ +P + + +QKL++++ +++
Sbjct: 527 LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNS 586
Query: 90 VGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSL--CRKLEVLSL 147
+ K+ + L L L+ +P + L L+ + + N L + +S +L L L
Sbjct: 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646
Query: 148 SHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQH 207
+N ++ +P +L+ L +L L+ N IP +F ++L +L + N L + I
Sbjct: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 208 LASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
L +LQ N I + P L L L+L NN +Q+LPS + L L +I
Sbjct: 707 LQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759
Score = 58.9 bits (141), Expect = 5e-09
Identities = 70/273 (25%), Positives = 109/273 (39%), Gaps = 64/273 (23%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLK-SLPREVSLLQC 118
++ IPD ++ L E++ L L +PP + +LT + L L K P L +
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494
Query: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNC--------------------------- 151
L+ L + + E+P + + LE L L+ N
Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554
Query: 152 LSQLPACFADLS-RLRKLNLSNN------------------------FFAHIPMCVFSLK 186
LS+LP D+ L+KL+++N IP +FSL
Sbjct: 555 LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLH 614
Query: 187 ELIFLHVGSNRLENIAE--SIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDI 244
L + + N L+ I E S QHL L N+I P + +T+LE L LN N I
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 245 QTLPSELHLLCRLVRIAWNPMDKGLHISHNPLS 277
+ +P++L CR +R L +SHN L+
Sbjct: 675 EKIPTQL-FYCRKLRY--------LDLSHNNLT 698
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 87.0 bits (214), Expect = 2e-17
Identities = 52/182 (28%), Positives = 95/182 (52%)
Query: 70 LSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCL 129
L+++Q L L NQL++LP + +LT++ L+L N +P + L LK +++ N L
Sbjct: 160 LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRL 219
Query: 130 TEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELI 189
T +P + ++L L +S N + + + L+ L LS+N +P + SLK +
Sbjct: 220 TFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
Query: 190 FLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPS 249
L + N+L + +SI L S++ N + + P S+ +T+L ++N +Q LP
Sbjct: 280 TLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPP 339
Query: 250 EL 251
E+
Sbjct: 340 EI 341
Score = 81.6 bits (200), Expect = 8e-16
Identities = 62/224 (27%), Positives = 108/224 (48%), Gaps = 9/224 (4%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
++ +PD L + +L L+ L LP G+LT++ +L L N+LK LP+ ++ L L
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
+ L + N TEVP L L+ + N L+ +P L +L L++S N +
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
Query: 180 MCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNL 239
+ + + L L + SN L+ + E+I L ++ + N + P S+ + S+E L+
Sbjct: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDC 306
Query: 240 NNNDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPEL 283
+ N+++ LPS + L L A HN L + PE+
Sbjct: 307 SFNEVEALPSSIGQLTNLRTFA---------ADHNYLQQLPPEI 341
Score = 77.4 bits (189), Expect = 1e-14
Identities = 54/198 (27%), Positives = 90/198 (45%)
Query: 54 SLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREV 113
SL +T +P + L +++L++S N ++ P + + ++ N + LP
Sbjct: 75 SLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGF 134
Query: 114 SLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNN 173
S L L L++N L +PA KL++L L N L LP L++L +L+L +N
Sbjct: 135 SQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSN 194
Query: 174 FFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTS 233
F +P + L L + +NRL I I L L NNI + +
Sbjct: 195 EFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCEN 254
Query: 234 LELLNLNNNDIQTLPSEL 251
L+ L L++N +Q LP +
Sbjct: 255 LQDLLLSSNSLQQLPETI 272
Score = 76.3 bits (186), Expect = 3e-14
Identities = 47/184 (25%), Positives = 90/184 (48%)
Query: 62 DIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKV 121
++P L+ + KL+L N L LP + L + L++ N ++ P + + L +
Sbjct: 60 ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119
Query: 122 LFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMC 181
+ ++N ++++P S L L L+ L LPA F L++L+ L L N +P
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNN 241
+ L +L L +GSN + E ++ L+ L+ F + N + P + + L L+++
Sbjct: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
Query: 242 NDIQ 245
N+I+
Sbjct: 240 NNIE 243
Score = 73.6 bits (179), Expect = 2e-13
Identities = 45/171 (26%), Positives = 84/171 (49%), Gaps = 1/171 (0%)
Query: 91 GKLTRIVVLNLCGNRLKSLPREVSLLQ-CLKVLFVNMNCLTEVPAELSLCRKLEVLSLSH 149
G+ + L+ L+ +P+E+ + L+ L+++ N + E+P +L C+ L LSL
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 150 NCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLA 209
N L+ LPA A+L LR+L++S N P + + K L + N + + + L
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLL 138
Query: 210 SLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
+L + P + +T L++L L N ++ LP ++ L +L R+
Sbjct: 139 NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERL 189
Score = 73.6 bits (179), Expect = 2e-13
Identities = 40/111 (36%), Positives = 65/111 (58%)
Query: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVL 122
+PD + GL V++L+ S N++ LP +G+LT + N L+ LP E+ + + VL
Sbjct: 291 LPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVL 350
Query: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNN 173
F++ N L +P E+ +KL+V++LS N L LP F L +L + LS+N
Sbjct: 351 FLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN 401
Score = 72.0 bits (175), Expect = 6e-13
Identities = 38/143 (26%), Positives = 71/143 (49%)
Query: 55 LVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVS 114
L + + +P+ + L + L + NQL LP +G L + L+ N +++LP +
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG 319
Query: 115 LLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNF 174
L L+ + N L ++P E+ + + VL L N L LP D+ +L+ +NLS+N
Sbjct: 320 QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
Query: 175 FAHIPMCVFSLKELIFLHVGSNR 197
++P L++L + + N+
Sbjct: 380 LKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 68.2 bits (165), Expect = 9e-12
Identities = 48/185 (25%), Positives = 91/185 (49%)
Query: 73 VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEV 132
+++L L NQ+ LP ++ + L+L N L +LP ++ L L+ L V+ N + E
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 133 PAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLH 192
P + C+ L ++ S N +S+LP F+ L L +L L++ F +P L +L L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 193 VGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELH 252
+ N+L+ + +++ L L+ N P L ++ L+ ++ N + +P +
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG 227
Query: 253 LLCRL 257
L +L
Sbjct: 228 SLKQL 232
Score = 60.1 bits (144), Expect = 2e-09
Identities = 39/139 (28%), Positives = 65/139 (46%)
Query: 73 VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEV 132
+Q L LS N L+ LP +G L I L + N+L LP + L ++ L + N + +
Sbjct: 255 LQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEAL 314
Query: 133 PAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLH 192
P+ + L + HN L QLP + L L +N +P + +++L ++
Sbjct: 315 PSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVIN 374
Query: 193 VGSNRLENIAESIQHLASL 211
+ NRL+N+ S L L
Sbjct: 375 LSDNRLKNLPFSFTKLQQL 393
Score = 42.4 bits (98), Expect = 5e-04
Identities = 33/120 (27%), Positives = 51/120 (42%), Gaps = 1/120 (0%)
Query: 145 LSLSHNCLSQLPA-CFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAE 203
L SH L Q+P F L +L L N +P +F+ + L L + N L +
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
Query: 204 SIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAWN 263
SI +L +L+ N I FP ++ L ++ + N I LP L L ++ N
Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
Score = 28.9 bits (63), Expect = 5.8
Identities = 14/47 (29%), Positives = 28/47 (59%)
Query: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSL 109
+P+ + + +++ +NLS N+L+ LP KL ++ + L N+ K L
Sbjct: 360 LPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 87.0 bits (214), Expect = 2e-17
Identities = 52/182 (28%), Positives = 95/182 (52%)
Query: 70 LSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCL 129
L+++Q L L NQL++LP + +LT++ L+L N +P + L LK +++ N L
Sbjct: 160 LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRL 219
Query: 130 TEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELI 189
T +P + ++L L +S N + + + L+ L LS+N +P + SLK +
Sbjct: 220 TFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
Query: 190 FLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPS 249
L + N+L + +SI L S++ N + + P S+ +T+L ++N +Q LP
Sbjct: 280 TLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPP 339
Query: 250 EL 251
E+
Sbjct: 340 EI 341
Score = 81.6 bits (200), Expect = 8e-16
Identities = 62/224 (27%), Positives = 108/224 (48%), Gaps = 9/224 (4%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
++ +PD L + +L L+ L LP G+LT++ +L L N+LK LP+ ++ L L
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
+ L + N TEVP L L+ + N L+ +P L +L L++S N +
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
Query: 180 MCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNL 239
+ + + L L + SN L+ + E+I L ++ + N + P S+ + S+E L+
Sbjct: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDC 306
Query: 240 NNNDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPEL 283
+ N+++ LPS + L L A HN L + PE+
Sbjct: 307 SFNEVEALPSSIGQLTNLRTFA---------ADHNYLQQLPPEI 341
Score = 77.4 bits (189), Expect = 1e-14
Identities = 54/198 (27%), Positives = 90/198 (45%)
Query: 54 SLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREV 113
SL +T +P + L +++L++S N ++ P + + ++ N + LP
Sbjct: 75 SLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGF 134
Query: 114 SLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNN 173
S L L L++N L +PA KL++L L N L LP L++L +L+L +N
Sbjct: 135 SQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSN 194
Query: 174 FFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTS 233
F +P + L L + +NRL I I L L NNI + +
Sbjct: 195 EFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCEN 254
Query: 234 LELLNLNNNDIQTLPSEL 251
L+ L L++N +Q LP +
Sbjct: 255 LQDLLLSSNSLQQLPETI 272
Score = 76.3 bits (186), Expect = 3e-14
Identities = 47/184 (25%), Positives = 90/184 (48%)
Query: 62 DIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKV 121
++P L+ + KL+L N L LP + L + L++ N ++ P + + L +
Sbjct: 60 ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119
Query: 122 LFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMC 181
+ ++N ++++P S L L L+ L LPA F L++L+ L L N +P
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNN 241
+ L +L L +GSN + E ++ L+ L+ F + N + P + + L L+++
Sbjct: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
Query: 242 NDIQ 245
N+I+
Sbjct: 240 NNIE 243
Score = 73.6 bits (179), Expect = 2e-13
Identities = 45/171 (26%), Positives = 84/171 (49%), Gaps = 1/171 (0%)
Query: 91 GKLTRIVVLNLCGNRLKSLPREVSLLQ-CLKVLFVNMNCLTEVPAELSLCRKLEVLSLSH 149
G+ + L+ L+ +P+E+ + L+ L+++ N + E+P +L C+ L LSL
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 150 NCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLA 209
N L+ LPA A+L LR+L++S N P + + K L + N + + + L
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLL 138
Query: 210 SLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
+L + P + +T L++L L N ++ LP ++ L +L R+
Sbjct: 139 NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERL 189
Score = 73.6 bits (179), Expect = 2e-13
Identities = 40/111 (36%), Positives = 65/111 (58%)
Query: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVL 122
+PD + GL V++L+ S N++ LP +G+LT + N L+ LP E+ + + VL
Sbjct: 291 LPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVL 350
Query: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNN 173
F++ N L +P E+ +KL+V++LS N L LP F L +L + LS+N
Sbjct: 351 FLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN 401
Score = 72.0 bits (175), Expect = 6e-13
Identities = 38/143 (26%), Positives = 71/143 (49%)
Query: 55 LVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVS 114
L + + +P+ + L + L + NQL LP +G L + L+ N +++LP +
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG 319
Query: 115 LLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNF 174
L L+ + N L ++P E+ + + VL L N L LP D+ +L+ +NLS+N
Sbjct: 320 QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
Query: 175 FAHIPMCVFSLKELIFLHVGSNR 197
++P L++L + + N+
Sbjct: 380 LKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 68.2 bits (165), Expect = 9e-12
Identities = 48/185 (25%), Positives = 91/185 (49%)
Query: 73 VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEV 132
+++L L NQ+ LP ++ + L+L N L +LP ++ L L+ L V+ N + E
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 133 PAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLH 192
P + C+ L ++ S N +S+LP F+ L L +L L++ F +P L +L L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 193 VGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELH 252
+ N+L+ + +++ L L+ N P L ++ L+ ++ N + +P +
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG 227
Query: 253 LLCRL 257
L +L
Sbjct: 228 SLKQL 232
Score = 60.1 bits (144), Expect = 2e-09
Identities = 39/139 (28%), Positives = 65/139 (46%)
Query: 73 VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEV 132
+Q L LS N L+ LP +G L I L + N+L LP + L ++ L + N + +
Sbjct: 255 LQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEAL 314
Query: 133 PAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLH 192
P+ + L + HN L QLP + L L +N +P + +++L ++
Sbjct: 315 PSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVIN 374
Query: 193 VGSNRLENIAESIQHLASL 211
+ NRL+N+ S L L
Sbjct: 375 LSDNRLKNLPFSFTKLQQL 393
Score = 42.4 bits (98), Expect = 5e-04
Identities = 33/120 (27%), Positives = 51/120 (42%), Gaps = 1/120 (0%)
Query: 145 LSLSHNCLSQLPA-CFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAE 203
L SH L Q+P F L +L L N +P +F+ + L L + N L +
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
Query: 204 SIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAWN 263
SI +L +L+ N I FP ++ L ++ + N I LP L L ++ N
Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
Score = 28.9 bits (63), Expect = 5.8
Identities = 14/47 (29%), Positives = 28/47 (59%)
Query: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSL 109
+P+ + + +++ +NLS N+L+ LP KL ++ + L N+ K L
Sbjct: 360 LPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 87.0 bits (214), Expect = 2e-17
Identities = 54/166 (32%), Positives = 90/166 (54%), Gaps = 2/166 (1%)
Query: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHI 178
L L ++ NCL+E+P L L L+++HN L LP LS L++L+LS N +
Sbjct: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
Query: 179 PMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLN 238
P + L L+ L++ SNRL+++ S+ L SL++ + N + S P L + L L+
Sbjct: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
Query: 239 LNNNDIQTLPSELHLLCRLVRIAWNPM-DKGLHISHNPLSKPLPEL 283
L +N ++ LP EL L VR+ NP+ + +P++ +PE+
Sbjct: 124 LRDNQLRDLPPEL-LDAPFVRLQGNPLGEASPDAPSSPVAALIPEM 168
Score = 74.3 bits (181), Expect = 1e-13
Identities = 46/117 (39%), Positives = 67/117 (57%), Gaps = 1/117 (0%)
Query: 51 VSFSLVTRG-MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSL 109
++F VT + +P L LS +Q+L+LS N L LPPE+G L ++ LNL NRL+SL
Sbjct: 27 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSL 86
Query: 110 PREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLR 166
P ++ L+ L++L ++ N L VPA+L+ L L L N L LP D +R
Sbjct: 87 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR 143
Score = 70.1 bits (170), Expect = 2e-12
Identities = 42/120 (35%), Positives = 68/120 (56%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
++++P+ L L + L ++HN+L+ LPP +G L+ + L+L N L +LP E+ L L
Sbjct: 14 LSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSL 73
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
L + N L +PA L+ R L +L L N L+ +PA A L L +L+L +N +P
Sbjct: 74 LELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 133
Score = 67.4 bits (163), Expect = 1e-11
Identities = 45/126 (35%), Positives = 65/126 (51%)
Query: 76 LNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAE 135
L LSHN L LP +G L + L + NRL++LP + L L+ L ++ N L +P E
Sbjct: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
Query: 136 LSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGS 195
+ L L+L+ N L LPA A L LR L L +N A +P + L L L +
Sbjct: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
Query: 196 NRLENI 201
N+L ++
Sbjct: 127 NQLRDL 132
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 86.3 bits (212), Expect = 3e-17
Identities = 59/175 (33%), Positives = 88/175 (50%), Gaps = 2/175 (1%)
Query: 62 DIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKV 121
++P+ L ++ L+L HN LR L P +G LT + LNL N+L LP + L L+V
Sbjct: 82 EVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRV 140
Query: 122 LFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMC 181
L V+ N L +P ++ L L +S N L LP+ LS LR LN+ N + +P
Sbjct: 141 LIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEE 200
Query: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLEL 236
+ L L+ L NR+ I S L LQ+ + + N + S P +CL L +
Sbjct: 201 LGDL-PLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHI 254
Score = 78.2 bits (191), Expect = 8e-15
Identities = 70/216 (32%), Positives = 99/216 (45%), Gaps = 23/216 (10%)
Query: 99 LNLCGNRLKSLPREVSL---LQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQL 155
LNL RLK PR + L + ++ N EVP LE LSL HNCL L
Sbjct: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
Query: 156 PACFADLSRLRKLNLSNNFFAHIP--MCVFSLKELIFLHVGSNRLENIAESIQHLASLQI 213
+L+ L LNLS N + +P +C L+ LI V +N+L + I L SL+
Sbjct: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLI---VSNNKLGALPPDIGTLGSLRQ 163
Query: 214 FIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAWN-------PMD 266
N + S P LC ++SL LN+ N + TLP EL L LVR+ ++ P+
Sbjct: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPVS 222
Query: 267 -------KGLHISHNPLSKPLPELVEGGLEMLFGYL 295
+ + + NPL P ++ G +F YL
Sbjct: 223 FCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYL 258
Score = 52.8 bits (125), Expect = 4e-07
Identities = 35/112 (31%), Positives = 56/112 (50%), Gaps = 1/112 (0%)
Query: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
+ +P L GLS ++ LN+ NQL LP E+G L +V L+ NR+ +P L+ L
Sbjct: 171 LQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSFCRLRHL 229
Query: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLS 171
+V+ ++ N L PA++ L KL + Q + DL+ R + S
Sbjct: 230 QVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFS 281
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 85.9 bits (211), Expect = 4e-17
Identities = 61/201 (30%), Positives = 101/201 (50%), Gaps = 4/201 (1%)
Query: 55 LVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVG--KLTRIVVLNLCGNRLKSLPRE 112
LV G+ IP ++ L +Q+L+L N LR + + ++V L L N++ +P
Sbjct: 589 LVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEH 648
Query: 113 VSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSN 172
V L+ L+ L+++ N L +P++L LC L +L +SHN L LP L L+ L LS
Sbjct: 649 VRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSY 708
Query: 173 NFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVT 232
N +P +F ++L L +G N+L ++ + L +L +GN + + P L
Sbjct: 709 NALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCG 768
Query: 233 SLELLNLNNND--IQTLPSEL 251
L+ L D Q LP+E+
Sbjct: 769 GLKKAGLLVEDTLYQGLPAEV 789
Score = 59.3 bits (142), Expect = 4e-09
Identities = 80/277 (28%), Positives = 111/277 (40%), Gaps = 66/277 (23%)
Query: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLK-SLPREVSLLQCLKV 121
+PD ++ LSEV+ L L PP + +L + L+L + + +V L LKV
Sbjct: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488
Query: 122 LFVNMNCLTEVP---------AELSL-------------------CRKLEVLSLSHNCLS 153
+ V L EVP EL L ++L+VLSL N
Sbjct: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA-G 547
Query: 154 QLPACFAD-------------------------LSRLRKLNLSNNFFAHIPMCVFSLKEL 188
++PA D L+ LR+L L IP VFSL L
Sbjct: 548 KVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGAL 607
Query: 189 IFLHVGSNRLENIAE--SIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQT 246
L + N L +I E S QH L N I P + + SLE L L+ N ++T
Sbjct: 608 QELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLET 667
Query: 247 LPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPEL 283
LPS+L LC +R+ L +SHN L PE+
Sbjct: 668 LPSQLG-LCSGLRL--------LDVSHNGLHSLPPEV 695
Score = 58.5 bits (140), Expect = 7e-09
Identities = 52/190 (27%), Positives = 87/190 (45%), Gaps = 27/190 (14%)
Query: 73 VQKLNLSHNQLRVLP-PEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTE 131
+Q+L+L ++ R++ + KL + L L L+ +P V L L+ L + N L
Sbjct: 560 LQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRS 619
Query: 132 VPAELSL--CRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELI 189
+ LS CRKL L L HN + A++P V L+ L
Sbjct: 620 IEEILSFQHCRKLVTLRLWHNQI-----------------------AYVPEHVRKLRSLE 656
Query: 190 FLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPS 249
L++ N+LE + + + L++ N +HS P + L+ +L+ L L+ N ++ LP
Sbjct: 657 QLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPE 716
Query: 250 ELHLLCRLVR 259
EL CR +R
Sbjct: 717 EL-FFCRKLR 725
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 82.8 bits (203), Expect = 3e-16
Identities = 58/209 (27%), Positives = 103/209 (49%), Gaps = 4/209 (1%)
Query: 44 LKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVG--KLTRIVVLNL 101
LK+ ++ S L++ + IP ++ L+ + +L+L N L+ + + L + L L
Sbjct: 581 LKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKL 640
Query: 102 CGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFAD 161
N + +P ++ L L+ L ++ N + +P +L LC KL L LS+N L+ +P
Sbjct: 641 WHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQY 700
Query: 162 LSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNI 221
LS L+ ++NN +P +F K+L L +G N L N++ + L++L GN +
Sbjct: 701 LSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYL 760
Query: 222 HSFPRSL--CLVTSLELLNLNNNDIQTLP 248
+ P L C L + N + TLP
Sbjct: 761 ETLPPELEGCQSLKRNCLIVEENLLNTLP 789
Score = 77.4 bits (189), Expect = 1e-14
Identities = 61/212 (28%), Positives = 99/212 (46%), Gaps = 9/212 (4%)
Query: 52 SFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLR-VLPPEVGKLTRIVVLNLCGNRLKSLP 110
S S + + +TD+ L +QKL+L + + V+ + K+ + L L L+ +P
Sbjct: 548 SLSRIPQVVTDL------LPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIP 601
Query: 111 REVSLLQCLKVLFVNMNCLTEVPAELSL--CRKLEVLSLSHNCLSQLPACFADLSRLRKL 168
+ L L L + N L V +S + L L L HN ++ +PA LS L +L
Sbjct: 602 HSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQL 661
Query: 169 NLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSL 228
+L +N ++P+ +F +L +L + N L I E IQ+L++LQ F NNI P L
Sbjct: 662 SLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGL 721
Query: 229 CLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
L+ L L N + L + L L +
Sbjct: 722 FQCKKLQCLLLGKNSLMNLSPHVGELSNLTHL 753
Score = 68.2 bits (165), Expect = 9e-12
Identities = 51/181 (28%), Positives = 86/181 (47%), Gaps = 2/181 (1%)
Query: 73 VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSL--LQCLKVLFVNMNCLT 130
++ L L L +P + L + L+L N LK++ +S LQ L L + N +
Sbjct: 587 LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIA 646
Query: 131 EVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIF 190
+PA++ LE LSL HN + LP ++L L+LS N IP + L L +
Sbjct: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
Query: 191 LHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSE 250
V +N +E + + + LQ + N++ + + +++L L L N ++TLP E
Sbjct: 707 FAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPE 766
Query: 251 L 251
L
Sbjct: 767 L 767
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,210,856
Number of Sequences: 37866
Number of extensions: 468493
Number of successful extensions: 2514
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 133
Number of HSP's that attempted gapping in prelim test: 1090
Number of HSP's gapped (non-prelim): 808
length of query: 301
length of database: 18,247,518
effective HSP length: 102
effective length of query: 199
effective length of database: 14,385,186
effective search space: 2862652014
effective search space used: 2862652014
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.