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Search of human proteins with 157671951
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157671951 solute carrier family 4, anion exchanger, member 3
isoform 1 [Homo sapiens]
(1232 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157671951 solute carrier family 4, anion exchanger, member 3 ... 2467 0.0
gi|157671953 solute carrier family 4, anion exchanger, member 3 ... 2452 0.0
gi|156071474 solute carrier family 4, anion exchanger, member 2 ... 1359 0.0
gi|4507021 solute carrier family 4, anion exchanger, member 1 [H... 954 0.0
gi|155722998 solute carrier family 4, sodium bicarbonate transpo... 657 0.0
gi|197927160 solute carrier family 4, sodium bicarbonate cotrans... 647 0.0
gi|4507025 solute carrier family 4, sodium bicarbonate cotranspo... 647 0.0
gi|148596928 solute carrier family 4, sodium bicarbonate cotrans... 647 0.0
gi|90403614 solute carrier family 4, sodium bicarbonate cotransp... 643 0.0
gi|90568034 solute carrier family 4, sodium bicarbonate cotransp... 643 0.0
gi|19743827 sodium bicarbonate transporter 4 isoform c [Homo sap... 606 e-173
gi|125987596 sodium bicarbonate transporter 4 isoform a [Homo sa... 598 e-170
gi|134288865 solute carrier family 4, sodium bicarbonate cotrans... 561 e-159
gi|151101449 solute carrier family 4, sodium bicarbonate cotrans... 557 e-158
gi|14042960 solute carrier family 4 member 11 [Homo sapiens] 253 1e-66
gi|239755981 PREDICTED: hypothetical protein XP_002344766 [Homo ... 55 3e-07
gi|239750506 PREDICTED: hypothetical protein XP_002347417 [Homo ... 55 3e-07
gi|239744803 PREDICTED: hypothetical protein XP_002343287 [Homo ... 55 3e-07
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 55 3e-07
gi|239757043 PREDICTED: functional smad suppressing element 18 [... 52 3e-06
gi|239751555 PREDICTED: functional smad suppressing element 18 [... 51 6e-06
gi|239746067 PREDICTED: functional smad suppressing element 18 [... 51 6e-06
gi|156104891 general transcription factor IIF, polypeptide 1, 74... 49 4e-05
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 47 1e-04
gi|182507165 thymus expressed gene 3-like [Homo sapiens] 47 1e-04
gi|4504733 insulin receptor substrate 4 [Homo sapiens] 46 2e-04
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 46 2e-04
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 46 2e-04
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap... 45 3e-04
gi|151101459 SAPS domain family, member 1 [Homo sapiens] 45 3e-04
>gi|157671951 solute carrier family 4, anion exchanger, member 3
isoform 1 [Homo sapiens]
Length = 1232
Score = 2467 bits (6393), Expect = 0.0
Identities = 1232/1232 (100%), Positives = 1232/1232 (100%)
Query: 1 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE 60
MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
Sbjct: 1 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE 60
Query: 61 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS 120
KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
Sbjct: 61 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS 120
Query: 121 EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG 180
EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG
Sbjct: 121 EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG 180
Query: 181 RAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSA 240
RAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSA
Sbjct: 181 RAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSA 240
Query: 241 LGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSG 300
LGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSG
Sbjct: 241 LGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSG 300
Query: 301 LAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGK 360
LAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGK
Sbjct: 301 LAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGK 360
Query: 361 PHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRT 420
PHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRT
Sbjct: 361 PHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRT 420
Query: 421 LLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWP 480
LLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWP
Sbjct: 421 LLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWP 480
Query: 481 HDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAV 540
HDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAV
Sbjct: 481 HDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAV 540
Query: 541 LLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSA 600
LLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSA
Sbjct: 541 LLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSA 600
Query: 601 ISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELS 660
ISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELS
Sbjct: 601 ISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELS 660
Query: 661 LELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAAL 720
LELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAAL
Sbjct: 661 LELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAAL 720
Query: 721 SPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFK 780
SPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFK
Sbjct: 721 SPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFK 780
Query: 781 FCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETF 840
FCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETF
Sbjct: 781 FCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETF 840
Query: 841 YKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPSPRNQPNTALLSLILM 900
YKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPSPRNQPNTALLSLILM
Sbjct: 841 YKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPSPRNQPNTALLSLILM 900
Query: 901 LGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGL 960
LGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGL
Sbjct: 901 LGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGL 960
Query: 961 SVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLK 1020
SVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLK
Sbjct: 961 SVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLK 1020
Query: 1021 GSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVRE 1080
GSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVRE
Sbjct: 1021 GSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVRE 1080
Query: 1081 QRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKH 1140
QRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKH
Sbjct: 1081 QRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKH 1140
Query: 1141 HPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLF 1200
HPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLF
Sbjct: 1141 HPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLF 1200
Query: 1201 QDRELQALDSEDAEPNFDEDGQDEYNELHMPV 1232
QDRELQALDSEDAEPNFDEDGQDEYNELHMPV
Sbjct: 1201 QDRELQALDSEDAEPNFDEDGQDEYNELHMPV 1232
>gi|157671953 solute carrier family 4, anion exchanger, member 3
isoform 2 [Homo sapiens]
Length = 1259
Score = 2452 bits (6355), Expect = 0.0
Identities = 1232/1259 (97%), Positives = 1232/1259 (97%), Gaps = 27/1259 (2%)
Query: 1 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE 60
MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
Sbjct: 1 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE 60
Query: 61 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS 120
KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
Sbjct: 61 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS 120
Query: 121 EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG 180
EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG
Sbjct: 121 EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG 180
Query: 181 RAAVTKPLPSVGPHTDKSPQHSS---------------------------SSPSPRARAS 213
RAAVTKPLPSVGPHTDKSPQHSS SSPSPRARAS
Sbjct: 181 RAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSPRARAS 240
Query: 214 RLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHR 273
RLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHR
Sbjct: 241 RLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHR 300
Query: 274 LEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRS 333
LEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRS
Sbjct: 301 LEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRS 360
Query: 334 QEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLP 393
QEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLP
Sbjct: 361 QEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLP 420
Query: 394 GIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNH 453
GIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNH
Sbjct: 421 GIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNH 480
Query: 454 HPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDA 513
HPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDA
Sbjct: 481 HPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDA 540
Query: 514 EATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGR 573
EATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGR
Sbjct: 541 EATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGR 600
Query: 574 SIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL 633
SIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL
Sbjct: 601 SIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL 660
Query: 634 RKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRY 693
RKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRY
Sbjct: 661 RKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRY 720
Query: 694 PHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVL 753
PHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVL
Sbjct: 721 PHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVL 780
Query: 754 FSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGS 813
FSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGS
Sbjct: 781 FSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGS 840
Query: 814 FLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPN 873
FLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPN
Sbjct: 841 FLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPN 900
Query: 874 GSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP 933
GSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP
Sbjct: 901 GSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP 960
Query: 934 ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPA 993
ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPA
Sbjct: 961 ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPA 1020
Query: 994 LLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRS 1053
LLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRS
Sbjct: 1021 LLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRS 1080
Query: 1054 VTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGI 1113
VTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGI
Sbjct: 1081 VTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGI 1140
Query: 1114 FLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVK 1173
FLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVK
Sbjct: 1141 FLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVK 1200
Query: 1174 STAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV 1232
STAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV
Sbjct: 1201 STAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV 1259
>gi|156071474 solute carrier family 4, anion exchanger, member 2
(erythrocyte membrane protein band 3-like 1) [Homo
sapiens]
Length = 1241
Score = 1359 bits (3517), Expect = 0.0
Identities = 738/1239 (59%), Positives = 891/1239 (71%), Gaps = 67/1239 (5%)
Query: 32 EEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPP 91
E+E+D+L +TL V RF +++ + + E+P RSY E DFE+HR +SHH HHPLS LPP
Sbjct: 32 EQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPP 91
Query: 92 PHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAE 151
+ R+ P R RR+ A P+ TP I+E EE+E+E E E
Sbjct: 92 DARRRKTPQGPGRKPRRR-----PGASPTGETPTIEEG-------EEDEDEASEAEGARA 139
Query: 152 PVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPS---- 207
+P P TP +F + D D + R + + P P PH + +P+ S + +
Sbjct: 140 LTQPSPVSTPSSVQFFLQED-DSADRKAERTSPSSPAPL--PHQEATPRASKGAQAGTQV 196
Query: 208 PRARASRLA-----------GEKSRPWSPSA----SYDLRERLCPGSALGNPGGPEQQVP 252
A A +A G RP + SY+L+ER GS G +VP
Sbjct: 197 EEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVP 256
Query: 253 TDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKK 309
TDE EAQ L +ADLD MKSHR ED PGVRRHLV+K ++ TQ GR G G P +
Sbjct: 257 TDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTP-----R 311
Query: 310 KKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFR 369
+ + +PHEVFVELNEL+LD++QEP WRETARWIKFEEDVEEETERWGKPHVASLSFR
Sbjct: 312 ARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFR 371
Query: 370 SLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPN 429
SLLELRRT+AHGA LLDL+Q TLPG+AH VVE M++SDQI+ EDRA+VLR LLLKHSHP+
Sbjct: 372 SLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPS 431
Query: 430 DDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEK 488
D+KD F PRN S+ S+ S+LG+HH + P P M G P + + +
Sbjct: 432 DEKDFSF-PRNISAGSLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLEVERERELP 487
Query: 489 PLHMPGGDGHRGKS---LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESV 545
P P G R KS LKLLEKIPE+AEATVVLVGCV FL +P AFVRL EAV L++V
Sbjct: 488 PPAPPAGIT-RSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAV 546
Query: 546 LEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFL 605
LEVPVPVRFLF++LGPS + DYHE+GRSI+TLMSDK FHEAAY AD+R+DLL+AI+ FL
Sbjct: 547 LEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFL 606
Query: 606 DGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGG 665
D S+V+PPSEV+G +LLRSVA FQR++L+KR E+ + +A K L L++
Sbjct: 607 DCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL-LQMVE 665
Query: 666 SEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAIT 725
+ EDDPL RTG FGGL+RDVRRRYPHY SD RDAL QC+AAV+FIYFAALSPAIT
Sbjct: 666 AAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAIT 725
Query: 726 FGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQ 785
FGGLLGEKT+ L+GVSELI+STA+ GV+F LLGAQPLLV+GFSGPLLVFEEAFF FC +
Sbjct: 726 FGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSN 785
Query: 786 DLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYK 845
LEYL GRVW+G WLV L +VA EGSFLVR++S FTQEIFAFLISLIFIYETFYKL K
Sbjct: 786 HLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVK 845
Query: 846 VFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPS-----------PRNQPNTAL 894
+F EHPL + + +D G + PT GP + PR QPNTAL
Sbjct: 846 IFQEHPL---HGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTAL 902
Query: 895 LSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKL 954
LSL+LM GTFFIAFFLRKF+NSRF G+ RR+IGDFG+PI+IL+MVLVDYSI DTYTQKL
Sbjct: 903 LSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKL 962
Query: 955 TVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQK 1014
+VP+G SVT+P+KR W I PLG PFP WMMVA+ +PA+LV ILIFMETQIT LI+S+K
Sbjct: 963 SVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKK 1022
Query: 1015 ARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQ 1074
R L KGSGFHLDLLLI ++GG+C LFGLPWL AATVRSVTH NALTVM A+APGDKP+
Sbjct: 1023 ERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPK 1082
Query: 1075 IQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLI 1134
IQEV+EQRVTG+L+A LVGLSIV+G +LR+IPLAVLFGIFLYMGVTSL+GIQ +RL L+
Sbjct: 1083 IQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLL 1142
Query: 1135 LMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHC 1194
LMP KHHP+ YV KV+T RMHLFT +QL C+ALLW V STAASLAFPF+L+LTVPLR
Sbjct: 1143 LMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMV 1202
Query: 1195 LLPRLFQDRELQALDSEDAEPNFDE-DGQDEYNELHMPV 1232
+L R+F DRE++ LD+ +AEP FDE +G DEYNE+ MPV
Sbjct: 1203 VLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1241
>gi|4507021 solute carrier family 4, anion exchanger, member 1 [Homo
sapiens]
Length = 911
Score = 954 bits (2466), Expect = 0.0
Identities = 512/918 (55%), Positives = 642/918 (69%), Gaps = 65/918 (7%)
Query: 319 HEVFVELNELMLD-RSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 377
H+V+VEL EL++D ++QE W E ARW++ EE++ E WG+PH++ L+F SLLELRR
Sbjct: 55 HKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGA-WGRPHLSHLTFWSLLELRRV 113
Query: 378 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFF 437
G LLDL++T+L G+A+ +++ I DQIRP+DR +LR LLLKHSH + + G
Sbjct: 114 FTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALG-- 171
Query: 438 PRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPA-PLWPHDPDAKEKPLHMPGGD 496
G P + G+P+ PL P + + G
Sbjct: 172 -------------------------GVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDG 206
Query: 497 GHRGKSLK-LLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFL 555
G G S +LEKIP D+EAT+VLVG FLEQP FVRL EA LE+V E+PVP+RFL
Sbjct: 207 GTEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAV-ELPVPIRFL 265
Query: 556 FVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSE 615
FV+LGP DY +LGR+ ATLMS+++F AY A R +LL ++ FLD S+V+PP++
Sbjct: 266 FVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTD 325
Query: 616 VEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPL 675
L S+ QRELLR+R + K + + G L+L G DDPL
Sbjct: 326 APSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKG---------LDLNGGP----DDPL 372
Query: 676 LRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTE 735
+TG +FGGLVRD+RRRYP+Y SD+ DA Q +AAV+FIYFAALSPAITFGGLLGEKT
Sbjct: 373 QQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTR 432
Query: 736 GLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVW 795
MGVSEL++STAV G+LF+LLGAQPLLVVGFSGPLLVFEEAFF FC LEY+ GRVW
Sbjct: 433 NQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVW 492
Query: 796 VGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPF 855
+G WL++ V+ +VA EGSFLVR+IS +TQEIF+FLISLIFIYETF KL K+F +HPL
Sbjct: 493 IGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKT 552
Query: 856 YPPEGALEGSLDAGLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRN 915
Y N +P +GP PNTALLSL+LM GTFF A LRKF+N
Sbjct: 553 Y--------------NYNVLMVPKPQGP-----LPNTALLSLVLMAGTFFFAMMLRKFKN 593
Query: 916 SRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPL 975
S + GK RR+IGDFG+PISIL+MVLVD+ I DTYTQKL+VP G V++ R W I PL
Sbjct: 594 SSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPL 653
Query: 976 GSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLG 1035
G FP WMM A+A+PALLV ILIF+E+QIT LIVS+ R+++KGSGFHLDLLL+ +G
Sbjct: 654 GLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMG 713
Query: 1036 GLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLS 1095
G+ LFG+PWL+A TVRSVTH NALTVM A PG QIQEV+EQR++G+L+A LVGLS
Sbjct: 714 GVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLS 773
Query: 1096 IVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRM 1155
I+M +L RIPLAVLFGIFLYMGVTSLSGIQL R+LL+ P K+HP+ PYV +VKTWRM
Sbjct: 774 ILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRM 833
Query: 1156 HLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEP 1215
HLFT IQ+ C+A+LWVVKST ASLA PF+L+LTVPLR LLP +F++ ELQ LD++DA+
Sbjct: 834 HLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKA 893
Query: 1216 NFD-EDGQDEYNELHMPV 1232
FD E+G+DEY+E+ MPV
Sbjct: 894 TFDEEEGRDEYDEVAMPV 911
>gi|155722998 solute carrier family 4, sodium bicarbonate
transporter-like, member 10 [Homo sapiens]
Length = 1088
Score = 657 bits (1696), Expect = 0.0
Identities = 396/984 (40%), Positives = 562/984 (57%), Gaps = 73/984 (7%)
Query: 266 LDDMKSHRLEDNPGVRRHLVKKPSRTQG---GRGSPSGLAPILRRK----KKKKKLDRRP 318
L KSHR + G +H + R G GR SPS P R + + + P
Sbjct: 56 LGGRKSHRRHRHRG-HKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHIP 114
Query: 319 HEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTI 378
H++F EL+E+ ++ WRETARW+KFEEDVE+ ERW KP+VA+LS SL ELR I
Sbjct: 115 HDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCI 174
Query: 379 AHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFP 438
+G LLD+ TL IA +V++ + S Q+ + R V L+ +H H N K + P
Sbjct: 175 LNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIP 234
Query: 439 RNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGH 498
S + +G P+ A ++ +D + + D H
Sbjct: 235 IVRSFAD----IGKKQSEPNSMDKNAGQVVSPQSAPACVENKNDVSRENSTVDFSKVDLH 290
Query: 499 RGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVM 558
++KIP AEA+ +LVG + FL++ AFVRL+ AVLL+ + EVP+P RFLF++
Sbjct: 291 ------FMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFIL 344
Query: 559 LGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEG 618
LGP YHE+GRSIATLM+D++FH+ AY+A DR DL+S I EFLD V+PP E +
Sbjct: 345 LGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWD- 403
Query: 619 RDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRT 678
+ + E + +E+ K+ G TA E E G + PE L RT
Sbjct: 404 -------PSIRIEPPKNVPSQEKRKIPAVPNG--TAAHGEA--EPHGGHSGPE---LQRT 449
Query: 679 GSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLM 738
G +FGGL+ D++R+ P++ SD RDA QC+A+ LF+Y A +SP ITFGGLLGE TEG +
Sbjct: 450 GRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRI 509
Query: 739 GVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGL 798
E + ++ G+ +SL G QPL ++G +GP+LVFE+ FKFC+ L YL+ R +GL
Sbjct: 510 SAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGL 569
Query: 799 WLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHP------- 851
W + LVA + S LV YI+ FT+E FA LI +IFIYE KL+++ +P
Sbjct: 570 WTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDL 629
Query: 852 -LLPFY-----PPEGALEGSLDAGLEPNGSA-------LPPTE-------------GPPS 885
LL Y P G+L E N SA L +E G
Sbjct: 630 ELLTQYSCNCVEPHNPSNGTLKEWRESNISASDIIWENLTVSECKSLHGEYVGRACGHDH 689
Query: 886 PRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYS 945
P P+ S+IL T ++ L++F+ SR+ K R I+ DF + ++IL MVL+DY+
Sbjct: 690 P-YVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYA 748
Query: 946 ITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQ 1005
I + KL VP+ T D R WF+ PLG P P W ++AA +PALL ILIFM+ Q
Sbjct: 749 I-GIPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQ 803
Query: 1006 ITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRT 1065
ITA+I+++K +L KG G+HLDLL++ + G+C + GLPW AATV S+THVN+L +
Sbjct: 804 ITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESE 863
Query: 1066 AIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGI 1125
APG++P+ +REQRVTG++I L+G S+ M ++L+ IP+ VL+G+FLYMG +SL GI
Sbjct: 864 CSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGI 923
Query: 1126 QLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLL 1185
Q R+ L MPAKH P+ Y+ V ++HLFT IQ+ C+ LLW++K + A++ FP ++
Sbjct: 924 QFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPMMV 983
Query: 1186 LLTVPLRHCLLPRLFQDRELQALD 1209
L V +R L+ LF REL LD
Sbjct: 984 LALVFVRK-LMDLLFTKRELSWLD 1006
>gi|197927160 solute carrier family 4, sodium bicarbonate
cotransporter, member 4 isoform 3 [Homo sapiens]
Length = 1094
Score = 647 bits (1669), Expect = 0.0
Identities = 385/953 (40%), Positives = 547/953 (57%), Gaps = 87/953 (9%)
Query: 318 PHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 377
P ++F EL+EL+ QE W+ETARWIKFEE VE+ ERW KPHVA+LS SL ELR
Sbjct: 105 PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 164
Query: 378 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKD-SGF 436
+ G+ +LD E ++LP + ++V+ I + ++PE + V TLL KH H +
Sbjct: 165 MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSL 224
Query: 437 FPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGD 496
+ SS + + N PD P M + L D +KP +
Sbjct: 225 ADIGKTVSSASRMFTN--------PDNGSPAMTHRNLTSSSL----NDISDKP------E 266
Query: 497 GHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLF 556
+ K+ K ++K+P DAEA+ VLVG V FL+ P AFVRL +AV+L ++ EVPVP RFLF
Sbjct: 267 KDQLKN-KFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLF 325
Query: 557 VMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEV 616
++LGP + YHE+GR+IATLMSD++FH+ AY+A DR DL++ I EFLD IV+PP E
Sbjct: 326 ILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEW 385
Query: 617 EGRDLLRSVAAFQRELLRKRR----EREQTKVEMTTRGGYTAPGKELSLELGGSEATPED 672
+ + + RK E Q + GG+ GG E+
Sbjct: 386 DPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHG----------GGGHGDCEE 435
Query: 673 DPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGE 732
L RTG GGL++D++R+ P + SD DAL+ Q ++A+LFIY A ++ AITFGGLLG+
Sbjct: 436 --LQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGD 493
Query: 733 KTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTG 792
T+ + GV E + TAV G +F L QPL ++ +GP+LVFE F F + + +YL
Sbjct: 494 ATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEF 553
Query: 793 RVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL 852
R+W+GLW L LVA + SFLV+Y + FT+E F+ LIS IFIY+ F K+ K+ +P+
Sbjct: 554 RLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPI 613
Query: 853 LPFY-------------PPEGA-LEGSLDAGLEPNGSALPPTEGPPSPRNQ--------- 889
+ PP+ A + S D L P LP N
Sbjct: 614 NSNFKVGYNTLFSCTCVPPDPANISISNDTTLAP--EYLPTMSSTDMYHNTTFDWAFLSK 671
Query: 890 ------------------PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFG 931
P+ L+S IL LGT+ + L+KF+ S + AR++I DF
Sbjct: 672 KECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFA 731
Query: 932 IPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAV 991
I +SIL+ ++D ++ T KL VP+ TSP+ R WF+PP G P W+ +AAA+
Sbjct: 732 IILSILIFCVID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAI 786
Query: 992 PALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATV 1051
PALLV ILIFM+ QITA+IV++K +L KG+G+HLDL + L +C L LPW AATV
Sbjct: 787 PALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATV 846
Query: 1052 RSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLF 1111
S+ H+++L + APG++P+ VREQRVTG L+ L GLS+ M +L+ IP+ VL+
Sbjct: 847 ISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLY 906
Query: 1112 GIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWV 1171
G+FLYMGV SL+G+Q RL L+LMP KH P+ Y+ V R+HLFT +Q+ C+ALLW+
Sbjct: 907 GVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWI 966
Query: 1172 VKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDE 1224
+KST A++ FP ++L V +R + LF +L LD D P D+ +++
Sbjct: 967 LKSTVAAIIFPVMILALVAVRKG-MDYLFSQHDLSFLD--DVIPEKDKKKKED 1016
>gi|4507025 solute carrier family 4, sodium bicarbonate cotransporter,
member 4 isoform 2 [Homo sapiens]
Length = 1035
Score = 647 bits (1669), Expect = 0.0
Identities = 385/953 (40%), Positives = 547/953 (57%), Gaps = 87/953 (9%)
Query: 318 PHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 377
P ++F EL+EL+ QE W+ETARWIKFEE VE+ ERW KPHVA+LS SL ELR
Sbjct: 61 PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 120
Query: 378 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKD-SGF 436
+ G+ +LD E ++LP + ++V+ I + ++PE + V TLL KH H +
Sbjct: 121 MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSL 180
Query: 437 FPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGD 496
+ SS + + N PD P M + L D +KP +
Sbjct: 181 ADIGKTVSSASRMFTN--------PDNGSPAMTHRNLTSSSL----NDISDKP------E 222
Query: 497 GHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLF 556
+ K+ K ++K+P DAEA+ VLVG V FL+ P AFVRL +AV+L ++ EVPVP RFLF
Sbjct: 223 KDQLKN-KFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLF 281
Query: 557 VMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEV 616
++LGP + YHE+GR+IATLMSD++FH+ AY+A DR DL++ I EFLD IV+PP E
Sbjct: 282 ILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEW 341
Query: 617 EGRDLLRSVAAFQRELLRKRR----EREQTKVEMTTRGGYTAPGKELSLELGGSEATPED 672
+ + + RK E Q + GG+ GG E+
Sbjct: 342 DPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHG----------GGGHGDCEE 391
Query: 673 DPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGE 732
L RTG GGL++D++R+ P + SD DAL+ Q ++A+LFIY A ++ AITFGGLLG+
Sbjct: 392 --LQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGD 449
Query: 733 KTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTG 792
T+ + GV E + TAV G +F L QPL ++ +GP+LVFE F F + + +YL
Sbjct: 450 ATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEF 509
Query: 793 RVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL 852
R+W+GLW L LVA + SFLV+Y + FT+E F+ LIS IFIY+ F K+ K+ +P+
Sbjct: 510 RLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPI 569
Query: 853 LPFY-------------PPEGA-LEGSLDAGLEPNGSALPPTEGPPSPRNQ--------- 889
+ PP+ A + S D L P LP N
Sbjct: 570 NSNFKVGYNTLFSCTCVPPDPANISISNDTTLAP--EYLPTMSSTDMYHNTTFDWAFLSK 627
Query: 890 ------------------PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFG 931
P+ L+S IL LGT+ + L+KF+ S + AR++I DF
Sbjct: 628 KECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFA 687
Query: 932 IPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAV 991
I +SIL+ ++D ++ T KL VP+ TSP+ R WF+PP G P W+ +AAA+
Sbjct: 688 IILSILIFCVID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAI 742
Query: 992 PALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATV 1051
PALLV ILIFM+ QITA+IV++K +L KG+G+HLDL + L +C L LPW AATV
Sbjct: 743 PALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATV 802
Query: 1052 RSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLF 1111
S+ H+++L + APG++P+ VREQRVTG L+ L GLS+ M +L+ IP+ VL+
Sbjct: 803 ISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLY 862
Query: 1112 GIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWV 1171
G+FLYMGV SL+G+Q RL L+LMP KH P+ Y+ V R+HLFT +Q+ C+ALLW+
Sbjct: 863 GVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWI 922
Query: 1172 VKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDE 1224
+KST A++ FP ++L V +R + LF +L LD D P D+ +++
Sbjct: 923 LKSTVAAIIFPVMILALVAVRKG-MDYLFSQHDLSFLD--DVIPEKDKKKKED 972
>gi|148596928 solute carrier family 4, sodium bicarbonate
cotransporter, member 4 isoform 1 [Homo sapiens]
Length = 1079
Score = 647 bits (1669), Expect = 0.0
Identities = 385/953 (40%), Positives = 547/953 (57%), Gaps = 87/953 (9%)
Query: 318 PHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 377
P ++F EL+EL+ QE W+ETARWIKFEE VE+ ERW KPHVA+LS SL ELR
Sbjct: 105 PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 164
Query: 378 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKD-SGF 436
+ G+ +LD E ++LP + ++V+ I + ++PE + V TLL KH H +
Sbjct: 165 MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSL 224
Query: 437 FPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGD 496
+ SS + + N PD P M + L D +KP +
Sbjct: 225 ADIGKTVSSASRMFTN--------PDNGSPAMTHRNLTSSSL----NDISDKP------E 266
Query: 497 GHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLF 556
+ K+ K ++K+P DAEA+ VLVG V FL+ P AFVRL +AV+L ++ EVPVP RFLF
Sbjct: 267 KDQLKN-KFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLF 325
Query: 557 VMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEV 616
++LGP + YHE+GR+IATLMSD++FH+ AY+A DR DL++ I EFLD IV+PP E
Sbjct: 326 ILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEW 385
Query: 617 EGRDLLRSVAAFQRELLRKRR----EREQTKVEMTTRGGYTAPGKELSLELGGSEATPED 672
+ + + RK E Q + GG+ GG E+
Sbjct: 386 DPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHG----------GGGHGDCEE 435
Query: 673 DPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGE 732
L RTG GGL++D++R+ P + SD DAL+ Q ++A+LFIY A ++ AITFGGLLG+
Sbjct: 436 --LQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGD 493
Query: 733 KTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTG 792
T+ + GV E + TAV G +F L QPL ++ +GP+LVFE F F + + +YL
Sbjct: 494 ATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEF 553
Query: 793 RVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL 852
R+W+GLW L LVA + SFLV+Y + FT+E F+ LIS IFIY+ F K+ K+ +P+
Sbjct: 554 RLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPI 613
Query: 853 LPFY-------------PPEGA-LEGSLDAGLEPNGSALPPTEGPPSPRNQ--------- 889
+ PP+ A + S D L P LP N
Sbjct: 614 NSNFKVGYNTLFSCTCVPPDPANISISNDTTLAP--EYLPTMSSTDMYHNTTFDWAFLSK 671
Query: 890 ------------------PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFG 931
P+ L+S IL LGT+ + L+KF+ S + AR++I DF
Sbjct: 672 KECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFA 731
Query: 932 IPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAV 991
I +SIL+ ++D ++ T KL VP+ TSP+ R WF+PP G P W+ +AAA+
Sbjct: 732 IILSILIFCVID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAI 786
Query: 992 PALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATV 1051
PALLV ILIFM+ QITA+IV++K +L KG+G+HLDL + L +C L LPW AATV
Sbjct: 787 PALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATV 846
Query: 1052 RSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLF 1111
S+ H+++L + APG++P+ VREQRVTG L+ L GLS+ M +L+ IP+ VL+
Sbjct: 847 ISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLY 906
Query: 1112 GIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWV 1171
G+FLYMGV SL+G+Q RL L+LMP KH P+ Y+ V R+HLFT +Q+ C+ALLW+
Sbjct: 907 GVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWI 966
Query: 1172 VKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDE 1224
+KST A++ FP ++L V +R + LF +L LD D P D+ +++
Sbjct: 967 LKSTVAAIIFPVMILALVAVRKG-MDYLFSQHDLSFLD--DVIPEKDKKKKED 1016
>gi|90403614 solute carrier family 4, sodium bicarbonate
cotransporter, member 8 isoform a [Homo sapiens]
Length = 1093
Score = 643 bits (1658), Expect = 0.0
Identities = 370/928 (39%), Positives = 534/928 (57%), Gaps = 71/928 (7%)
Query: 318 PHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 377
PHE+F EL+E+ + ++ W+ETARW+KFEEDVE+ ERW KP+VA+LS SL ELR
Sbjct: 113 PHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSC 172
Query: 378 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFF 437
+ +G LLD+ ++ I+ L+++ +S + R V LL KH H N+ K +
Sbjct: 173 LINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLI 232
Query: 438 PRNPSSSSMNSVLGNHHPTPSHGPD---GAVPTMADDLGEPAPLWPHDPDAKEKPLHMPG 494
P S + + + H HG +VPT ++ + + + P+ +
Sbjct: 233 PIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEV-------KNGVNCEHSPVDLSK 285
Query: 495 GDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRF 554
D H ++KIP AEA+ VLVG V L++P AFVRL+ AVLL + EVP+P RF
Sbjct: 286 VDLH------FMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRF 339
Query: 555 LFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPS 614
LF++LGP YHE+GRS+AT+M+D++FH+ AY+A +R DLL+ I EFLD V+PP
Sbjct: 340 LFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPG 399
Query: 615 EVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDP 674
E + + + E + +E+ K+ G + E G + PE
Sbjct: 400 EWD--------PSIRIEPPKNVPSQEKRKMPGVPNGNVC----HIEQEPHGGHSGPE--- 444
Query: 675 LLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKT 734
L RTG +FGGLV D++R+ P Y SD RDAL QC+A+ LF+Y A +SP ITFGGLLGE T
Sbjct: 445 LQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEAT 504
Query: 735 EGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRV 794
EG + E + ++ G+ +SL Q L ++G +GP+LVFE+ FKFC+ L YL+ R
Sbjct: 505 EGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRA 564
Query: 795 WVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL-- 852
+GLW + LVA + S LV YI+ FT+E FA LI +IFIYE KL + +P+
Sbjct: 565 CIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHM 624
Query: 853 ---------------LPFYPPEGALEGSLDAGL----------------EPNGSALPPTE 881
LP P L+ D + E +G +
Sbjct: 625 HSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSAC 684
Query: 882 GPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVL 941
G P P+ S IL TF ++ L+ F+ SR+ + R ++ DF + ++I MV+
Sbjct: 685 GHHGPYT-PDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVI 743
Query: 942 VDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIF 1001
+D+ I + KL VP+ T D R W I P+G P P W ++AA +PALL ILIF
Sbjct: 744 IDFLI-GVPSPKLQVPSVFKPTR-DDRGWIINPIG---PNPWWTVIAAIIPALLCTILIF 798
Query: 1002 METQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALT 1061
M+ QITA+I+++K +L KG G+HLDLL++ + G+C + GLPW AATV S+THVN+L
Sbjct: 799 MDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLK 858
Query: 1062 VMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTS 1121
+ APG++P+ +REQRVTG++I L+G S+ M A+L+ IP+ VL+G+FLYMGV+S
Sbjct: 859 LESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSS 918
Query: 1122 LSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAF 1181
L GIQ RL L MPAKH P+ Y+ V ++HLFT IQL C+ LLWV+K++ A++ F
Sbjct: 919 LQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVF 978
Query: 1182 PFLLLLTVPLRHCLLPRLFQDRELQALD 1209
P ++L V +R ++ F REL LD
Sbjct: 979 PMMVLALVFVRK-VMDLCFSKRELSWLD 1005
>gi|90568034 solute carrier family 4, sodium bicarbonate
cotransporter, member 8 isoform b [Homo sapiens]
Length = 1044
Score = 643 bits (1658), Expect = 0.0
Identities = 370/928 (39%), Positives = 534/928 (57%), Gaps = 71/928 (7%)
Query: 318 PHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 377
PHE+F EL+E+ + ++ W+ETARW+KFEEDVE+ ERW KP+VA+LS SL ELR
Sbjct: 113 PHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSC 172
Query: 378 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFF 437
+ +G LLD+ ++ I+ L+++ +S + R V LL KH H N+ K +
Sbjct: 173 LINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLI 232
Query: 438 PRNPSSSSMNSVLGNHHPTPSHGPD---GAVPTMADDLGEPAPLWPHDPDAKEKPLHMPG 494
P S + + + H HG +VPT ++ + + + P+ +
Sbjct: 233 PIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEV-------KNGVNCEHSPVDLSK 285
Query: 495 GDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRF 554
D H ++KIP AEA+ VLVG V L++P AFVRL+ AVLL + EVP+P RF
Sbjct: 286 VDLH------FMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRF 339
Query: 555 LFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPS 614
LF++LGP YHE+GRS+AT+M+D++FH+ AY+A +R DLL+ I EFLD V+PP
Sbjct: 340 LFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPG 399
Query: 615 EVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDP 674
E + + + E + +E+ K+ G + E G + PE
Sbjct: 400 EWD--------PSIRIEPPKNVPSQEKRKMPGVPNGNVC----HIEQEPHGGHSGPE--- 444
Query: 675 LLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKT 734
L RTG +FGGLV D++R+ P Y SD RDAL QC+A+ LF+Y A +SP ITFGGLLGE T
Sbjct: 445 LQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEAT 504
Query: 735 EGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRV 794
EG + E + ++ G+ +SL Q L ++G +GP+LVFE+ FKFC+ L YL+ R
Sbjct: 505 EGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRA 564
Query: 795 WVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL-- 852
+GLW + LVA + S LV YI+ FT+E FA LI +IFIYE KL + +P+
Sbjct: 565 CIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHM 624
Query: 853 ---------------LPFYPPEGALEGSLDAGL----------------EPNGSALPPTE 881
LP P L+ D + E +G +
Sbjct: 625 HSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSAC 684
Query: 882 GPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVL 941
G P P+ S IL TF ++ L+ F+ SR+ + R ++ DF + ++I MV+
Sbjct: 685 GHHGPYT-PDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVI 743
Query: 942 VDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIF 1001
+D+ I + KL VP+ T D R W I P+G P P W ++AA +PALL ILIF
Sbjct: 744 IDFLI-GVPSPKLQVPSVFKPTR-DDRGWIINPIG---PNPWWTVIAAIIPALLCTILIF 798
Query: 1002 METQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALT 1061
M+ QITA+I+++K +L KG G+HLDLL++ + G+C + GLPW AATV S+THVN+L
Sbjct: 799 MDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLK 858
Query: 1062 VMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTS 1121
+ APG++P+ +REQRVTG++I L+G S+ M A+L+ IP+ VL+G+FLYMGV+S
Sbjct: 859 LESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSS 918
Query: 1122 LSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAF 1181
L GIQ RL L MPAKH P+ Y+ V ++HLFT IQL C+ LLWV+K++ A++ F
Sbjct: 919 LQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVF 978
Query: 1182 PFLLLLTVPLRHCLLPRLFQDRELQALD 1209
P ++L V +R ++ F REL LD
Sbjct: 979 PMMVLALVFVRK-VMDLCFSKRELSWLD 1005
>gi|19743827 sodium bicarbonate transporter 4 isoform c [Homo sapiens]
Length = 1121
Score = 606 bits (1563), Expect = e-173
Identities = 369/960 (38%), Positives = 535/960 (55%), Gaps = 87/960 (9%)
Query: 321 VFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAH 380
+F E++ L D Q W+E+ARWIKFEE VEE ERW KPHV++LS SL ELR +
Sbjct: 113 LFTEMDTLQHDGDQM-EWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQT 171
Query: 381 GAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRN 440
G LLDL+ +LP I V+E I +RPE R V LL +H H P +
Sbjct: 172 GTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKK------PIH 225
Query: 441 PSSSSMNSVLGNHHPTPSHGPDGAVPTM---ADDLG-EPAPLWPHDPDAKEKPLH----M 492
S + + + + +P+ P GA P++ +DL + + A+ + ++
Sbjct: 226 RSLADIGKSVSTTNRSPARSP-GAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLT 284
Query: 493 PGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPV 552
P D + K +K KIP+D+EA+ VLVG V FL+QP AFVRL ++ +L V EVPVP
Sbjct: 285 PNTDQRKNKFMK---KIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPT 341
Query: 553 RFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIP 612
RFLF++LGPS + Y+E+GR+IATLM D LF + AY+A +R+DL++ I EFLD IV+P
Sbjct: 342 RFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLP 401
Query: 613 PSEVEGRDLLRSVAAFQRELLRKR--REREQTKVEMTTRGGYTAPG----------KELS 660
P E + + RK E ++ + GG APG
Sbjct: 402 PGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGG 461
Query: 661 LELGGSEATPEDDP------------LLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQC 708
GG+ T D L+ TG FGGL D++R+ P +PSD D H Q
Sbjct: 462 AGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQS 521
Query: 709 VAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFS 768
++A+LFIY ++ AITFGGLLG+ T+ GV E + TA+ G LF L QPL+++ +
Sbjct: 522 ISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSST 581
Query: 769 GPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFA 828
GP+L+FE+ F F + L+Y+ R+W+GL V L LVA + SF+++YI+ FT+E F+
Sbjct: 582 GPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFS 641
Query: 829 FLISLIFIYETFYKLYKVFTEHPL--------LPFYPPEGALEGSLDAGLEPNGSALPPT 880
LIS IFIY+ K+ F +P+ + Y E +++ + + L P
Sbjct: 642 TLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPD 701
Query: 881 EGPP------------------------------SPRNQPNTALLSLILMLGTFFIAFFL 910
S + P+ AL+S IL GT+ + L
Sbjct: 702 TNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTL 761
Query: 911 RKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSW 970
+KF+ SR+ K R ++ DF I SIL+ +D + T KL VP+ + T PD R W
Sbjct: 762 KKFKFSRYFPTKVRALVADFSIVFSILMFCGID-ACFGLETPKLHVPSVIKPTRPD-RGW 819
Query: 971 FIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLL 1030
F+ P G P W+ A+ +PALLV ILIFM+ QITA+IV++K +L K +G+HLDL
Sbjct: 820 FVAPFGKN---PWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFW 876
Query: 1031 IGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIAS 1090
+G L LC GLPW AATV S+ H+++L + APG++PQ VREQRVTG+++
Sbjct: 877 VGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFI 936
Query: 1091 LVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKV 1150
L G+S+ + +L+ IPL VL+G+FLYMGV SL+GIQ +R L LMPAKH P+ ++ V
Sbjct: 937 LTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQFWERCKLFLMPAKHQPDHAFLRHV 996
Query: 1151 KTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDS 1210
R+HLFT +Q+ C+A+LW++KST A++ FP ++L + +R LL +F +L +D+
Sbjct: 997 PLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRR-LLDFIFSQHDLAWIDN 1055
>gi|125987596 sodium bicarbonate transporter 4 isoform a [Homo
sapiens]
Length = 1137
Score = 598 bits (1541), Expect = e-170
Identities = 369/976 (37%), Positives = 536/976 (54%), Gaps = 103/976 (10%)
Query: 321 VFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAH 380
+F E++ L D Q W+E+ARWIKFEE VEE ERW KPHV++LS SL ELR +
Sbjct: 113 LFTEMDTLQHDGDQM-EWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQT 171
Query: 381 GAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRN 440
G LLDL+ +LP I V+E I +RPE R V LL +H H P +
Sbjct: 172 GTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKK------PIH 225
Query: 441 PSSSSMNSVLGNHHPTPSHGPDGAVPTM---ADDLG-EPAPLWPHDPDAKEKPLH----M 492
S + + + + +P+ P GA P++ +DL + + A+ + ++
Sbjct: 226 RSLADIGKSVSTTNRSPARSP-GAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLT 284
Query: 493 PGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPV 552
P D + K +K KIP+D+EA+ VLVG V FL+QP AFVRL ++ +L V EVPVP
Sbjct: 285 PNTDQRKNKFMK---KIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPT 341
Query: 553 RFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIP 612
RFLF++LGPS + Y+E+GR+IATLM D LF + AY+A +R+DL++ I EFLD IV+P
Sbjct: 342 RFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLP 401
Query: 613 PSEVEGRDLLRSVAAFQRELLRKR--REREQTKVEMTTRGGYTAPG----------KELS 660
P E + + RK E ++ + GG APG
Sbjct: 402 PGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGG 461
Query: 661 LELGGSEATPEDDP------------LLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQC 708
GG+ T D L+ TG FGGL D++R+ P +PSD D H Q
Sbjct: 462 AGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQS 521
Query: 709 VAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFS 768
++A+LFIY ++ AITFGGLLG+ T+ GV E + TA+ G LF L QPL+++ +
Sbjct: 522 ISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSST 581
Query: 769 GPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFA 828
GP+L+FE+ F F + L+Y+ R+W+GL V L LVA + SF+++YI+ FT+E F+
Sbjct: 582 GPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFS 641
Query: 829 FLISLIFIYETFYKLYKVFTEHPL--------LPFYPPEGALEGSLDAGLEPNGSALPPT 880
LIS IFIY+ K+ F +P+ + Y E +++ + + L P
Sbjct: 642 TLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPD 701
Query: 881 EGPP------------------------------SPRNQPNTALLSLILMLGTFFIAFFL 910
S + P+ AL+S IL GT+ + L
Sbjct: 702 TNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTL 761
Query: 911 RKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSW 970
+KF+ SR+ K R ++ DF I SIL+ +D + T KL VP+ + T PD R W
Sbjct: 762 KKFKFSRYFPTKVRALVADFSIVFSILMFCGID-ACFGLETPKLHVPSVIKPTRPD-RGW 819
Query: 971 FIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLL 1030
F+ P G P W+ A+ +PALLV ILIFM+ QITA+IV++K +L K +G+HLDL
Sbjct: 820 FVAPFGKN---PWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFW 876
Query: 1031 IGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIAS 1090
+G L LC GLPW AATV S+ H+++L + APG++PQ VREQRVTG+++
Sbjct: 877 VGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFI 936
Query: 1091 LVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLS----------------QRLLLI 1134
L G+S+ + +L+ IPL VL+G+FLYMGV SL+GIQ+ +R L
Sbjct: 937 LTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLF 996
Query: 1135 LMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHC 1194
LMPAKH P+ ++ V R+HLFT +Q+ C+A+LW++KST A++ FP ++L + +R
Sbjct: 997 LMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRR- 1055
Query: 1195 LLPRLFQDRELQALDS 1210
LL +F +L +D+
Sbjct: 1056 LLDFIFSQHDLAWIDN 1071
>gi|134288865 solute carrier family 4, sodium bicarbonate
cotransporter, member 7 [Homo sapiens]
Length = 1214
Score = 561 bits (1445), Expect = e-159
Identities = 321/755 (42%), Positives = 455/755 (60%), Gaps = 55/755 (7%)
Query: 503 LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPS 562
+ + KIP AEA+ VLVG V FLE+P AFVRL AVLL + EVPVP RFLF++LGP+
Sbjct: 416 MNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPA 475
Query: 563 HTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLL 622
+ YHE+GRSIATLM+D++FH+ AY+A DR DLLS I EFLD V+PP E +
Sbjct: 476 GKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWD----- 530
Query: 623 RSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVF 682
+ + E + +E+ K+ + G G+ + + A PE L RTG +F
Sbjct: 531 ---PSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGE--TPKEAAHHAGPE---LQRTGRLF 582
Query: 683 GGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSE 742
GGL+ D++R+ P + SD +DAL QC+A++LF+Y A +SP ITFGGLLGE TEG + E
Sbjct: 583 GGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIE 642
Query: 743 LIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVV 802
+ ++ G+ +SL QPL ++G +GP+LVFE+ +KFCR L YL+ R +GLW
Sbjct: 643 SLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSF 702
Query: 803 FVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKV--------------FT 848
+ LVA + S LV YI+ FT+E FA LI +IFIYE KL+ + T
Sbjct: 703 LCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLT 762
Query: 849 EHPLLPFYPPEGALEG-------------------SLDAGLEPNGSALPPTEGPPSPRNQ 889
+ + PP + E ++ + G L G P
Sbjct: 763 SYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGP-YI 821
Query: 890 PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDT 949
P+ +IL TFF++ FL++F+ R+ K R I DF + ++I++MV +DY +
Sbjct: 822 PDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDY-LVGV 880
Query: 950 YTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITAL 1009
+ KL VP T P+ R W I PLG P W ++ AA+PALL ILIFM+ QITA+
Sbjct: 881 PSPKLHVPEKFEPTHPE-RGWIISPLGDN---PWWTLLIAAIPALLCTILIFMDQQITAV 936
Query: 1010 IVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAP 1069
I+++K +L KG+G+HLDLL++G + G+C + GLPW AATV S++HVN+L V AP
Sbjct: 937 IINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAP 996
Query: 1070 GDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQ 1129
G++P+ +REQRVTG++I L+GLS+ M +VL+ IP+ VL+G+FLYMGV+SL GIQL
Sbjct: 997 GEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFD 1056
Query: 1130 RLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTV 1189
R+ L MPAKH P+ Y+ V W++H+FT IQL C+ LLWV+K +AA++ FP ++L V
Sbjct: 1057 RIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALV 1116
Query: 1190 PLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDE 1224
+R L+ F REL LD D P + +D+
Sbjct: 1117 FVRK-LMDLCFTKRELSWLD--DLMPESKKKKEDD 1148
Score = 120 bits (301), Expect = 8e-27
Identities = 72/195 (36%), Positives = 103/195 (52%), Gaps = 8/195 (4%)
Query: 267 DDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRK----KKKKKLDRRPHEVF 322
+ + HR + R K S + GR SPS P R + + + PH++F
Sbjct: 54 ESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLF 113
Query: 323 VELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGA 382
E++EL +E W+ETARW+KFEEDVE+ +RW KP+VA+LS SL ELR I +G
Sbjct: 114 TEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGT 173
Query: 383 ALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPS 442
+LD+ +TL IA +V++ MI S Q+ R +V LL +H H N+ + F R P
Sbjct: 174 VMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKR---FTSRIPL 230
Query: 443 SSSMNSVLGNHHPTP 457
S + G H P
Sbjct: 231 VRSFADI-GKKHSDP 244
>gi|151101449 solute carrier family 4, sodium bicarbonate
cotransporter, member 9 [Homo sapiens]
Length = 959
Score = 557 bits (1436), Expect = e-158
Identities = 362/924 (39%), Positives = 494/924 (53%), Gaps = 100/924 (10%)
Query: 321 VFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAH 380
+F++LNEL L Q WRET RW+ FEE +E RW PHV +L+ SL +LR +A
Sbjct: 56 LFIQLNEL-LGWPQALEWRETGRWVLFEEKLEVAAGRWSAPHVPTLALPSLQKLRSLLAE 114
Query: 381 GAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRN 440
G LLD +L + VE + + + PE R + LL + H N
Sbjct: 115 GLVLLDCPAQSLLEL----VEQVTRVESLSPELRGQLQALLLQRPQHYNQ---------- 160
Query: 441 PSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRG 500
++ G+ HP + E APL + + PL
Sbjct: 161 --TTGTRPCWGSTHPRKASD------------NEEAPL----REQCQNPLR--------- 193
Query: 501 KSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLG 560
+K+P AEA VL G + FL QP AFVRL V+L S+ EV +P RF ++LG
Sbjct: 194 ------QKLPPGAEAGTVLAGELGFLAQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLG 247
Query: 561 PSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRD 620
P YHE+GR+ A L+SD F + +A + DLL+A+ FL+ V+PP +
Sbjct: 248 PCMLGKGYHEMGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLEEVTVLPPGRWDPTA 307
Query: 621 LL---RSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLR 677
+ + + + + L ++RE V T E G +PE L R
Sbjct: 308 RIPPPKCLPSQHKRLPSQQREIRGPAVPRLTSA-------EDRHRHGPHAHSPE---LQR 357
Query: 678 TGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGL 737
TG +FGGL++DVRR+ P YPSD DALH QC +AVL+IY A ++ AITFGGLLG+ T+G
Sbjct: 358 TGRLFGGLIQDVRRKVPWYPSDFLDALHLQCFSAVLYIYLATVTNAITFGGLLGDATDGA 417
Query: 738 MGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVG 797
GV E + TAV G F L+ QPL ++ +GP+LVFE F F R L+YL R+WVG
Sbjct: 418 QGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVG 477
Query: 798 LWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL----- 852
+W+ F L LVA E S LVRY + FT+E F LISLIFIY+ K+ + +P+
Sbjct: 478 IWVATFCLVLVATEASVLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGS 537
Query: 853 -----LPFYPPEGALEG--------------SLDAGLEPNGSALPPTEGP--------PS 885
L YP G E S+D GL N S LPP E P
Sbjct: 538 SAYGCLCQYPGPGGNESQWIRTRPKDRDDIVSMDLGLI-NASLLPPPECTRQGGHPRGPG 596
Query: 886 PRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYS 945
P+ A SL+L L +FF A L+ + SRF R+ + DF ++IL+ +D +
Sbjct: 597 CHTVPDIAFFSLLLFLTSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLD-A 655
Query: 946 ITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQ 1005
T KL VP T P R W + P G+ P W VAAA+PALL+ ILIFM+ Q
Sbjct: 656 FLGLATPKLMVPREFKPTLPG-RGWLVSPFGAN---PWWWSVAAALPALLLSILIFMDQQ 711
Query: 1006 ITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRT 1065
ITA+I+++ RL KG+GFHLDL + L L GLPW +ATV S+ H+++L
Sbjct: 712 ITAVILNRMEYRLQKGAGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESR 771
Query: 1066 AIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGI 1125
A APG++P +REQR+TG+++ L G SI + VL+ IP+ VL+GIFLYMGV +LS I
Sbjct: 772 ACAPGERPNFLGIREQRLTGLVVFILTGASIFLAPVLKFIPMPVLYGIFLYMGVAALSSI 831
Query: 1126 QLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLL 1185
Q + R+ L+LMPAKH P+ + V R+HLFT IQL C+ LLW++KST A++ FP +L
Sbjct: 832 QFTNRVKLLLMPAKHQPDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTPAAIIFPLML 891
Query: 1186 LLTVPLRHCLLPRLFQDRELQALD 1209
L V +R L R+F +EL LD
Sbjct: 892 LGLVGVRKA-LERVFSPQELLWLD 914
>gi|14042960 solute carrier family 4 member 11 [Homo sapiens]
Length = 891
Score = 253 bits (645), Expect = 1e-66
Identities = 200/690 (28%), Positives = 328/690 (47%), Gaps = 78/690 (11%)
Query: 552 VRFLFVMLGPSH--TSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSI 609
VRF+ ++L P ++ E+ R+ AT+ SD F RQ LL +E
Sbjct: 247 VRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAF---------RQKLLETRTE------ 291
Query: 610 VIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEAT 669
+ + QR+LL M + G KE S +
Sbjct: 292 ----------EEFKEALVHQRQLLT-----------MVSHGPVAPRTKERSTVSLPAHRH 330
Query: 670 PEDDPLLRTGSVFG-GLVRDVRRRYPHYPSDLRDALHSQ------CVAAVLFIYFAALSP 722
PE P + FG G+ D+ RR+P YP D D + + + LF+YFA L P
Sbjct: 331 PEP-PKCKDFVPFGKGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLP 389
Query: 723 AITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFC 782
I FG L E T+G + V + I ++ G+L++L QPL+++ + PL ++ + C
Sbjct: 390 TIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVIC 449
Query: 783 RAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYK 842
DL++ + W GLW F+ S ++ T+EI A IS+ F+ +
Sbjct: 450 DDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKG 509
Query: 843 LYKVFTE----HPLLPFYPPE-------GALEGSLDAGLEP--NGSAL-PPTEGPPSPRN 888
K+F + H L ++ L SL+A L N S L PTE P + +
Sbjct: 510 TVKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTALNASFLASPTELPSATHS 569
Query: 889 QPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLV-DYSIT 947
TA+LSL++MLGT ++ + L +F+ S +L R I+ D +PI++L L+ +
Sbjct: 570 GQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSHGFR 629
Query: 948 DTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVP-ALLVLILIFMETQI 1006
+ K +P + + + + S V+ A+ L+ +L F+E +
Sbjct: 630 EIEMSKFRY-------NPSESPFAMAQIQSL----SLRAVSGAMGLGFLLSMLFFIEQNL 678
Query: 1007 TALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTA 1066
A +V+ RL+KG+ +H DLLL+ + LFGLPW+ AA S HV AL ++
Sbjct: 679 VAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEER 738
Query: 1067 IAPGD-KPQIQEVREQRVTGVLIASLVGLSIVMGAV-LRRIPLAVLFGIFLYMGVTSLSG 1124
+ G I V+E R+T + + LVGLS+++ V L+ IP VL+G+FLY+ +TSL G
Sbjct: 739 VENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDG 798
Query: 1125 IQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTA---ASLAF 1181
QL QR+ L+L +P Y+ +V ++H FT +Q+ + LL ++ + F
Sbjct: 799 NQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIF 858
Query: 1182 PFLLLLTVPLRHCLLPRLFQDRELQALDSE 1211
P +++ +P+R+ LLPR+ + + L +D+E
Sbjct: 859 PLIMIAMIPIRYILLPRIIEAKYLDVMDAE 888
>gi|239755981 PREDICTED: hypothetical protein XP_002344766 [Homo
sapiens]
Length = 307
Score = 55.5 bits (132), Expect = 3e-07
Identities = 70/266 (26%), Positives = 98/266 (36%), Gaps = 47/266 (17%)
Query: 59 PEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAP 118
P P+ ++ R HT H T HP S+ PP H LPPT
Sbjct: 15 PANPAPFHTPRKRHPLSHTPHATAHPPSSP-PPLHITPVLPPTFP--------------- 58
Query: 119 PSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPP---PSGTPQKAKFSIGSDEDDS 175
GT P + A E ++EE ++ P+ PP G +GS
Sbjct: 59 ---GTQPPRALRLAEGSGEGKQEEGRRAQARPRPLRPPWEVRGGARGPCSAPVGSRASSG 115
Query: 176 PGLPGRAAV--TKPLPSVGPHTDKSPQHSSSS---PSPRARASRLAGEKSRPWSPSASYD 230
PGLP AA + + P + +SP +SS+ PR RL G RP SP+
Sbjct: 116 PGLPSAAAARPARKTLTCQPRSIESPATASSAGCGSGPRVPQVRLLGPGGRPSSPARDGS 175
Query: 231 LRER-------------LCPGSALGNPGGP--EQQVPTDEAEAQMLGSADLDDMKSHRLE 275
R+ A G+PGG Q++ EA ++ S ++ H
Sbjct: 176 RRKAGHGCTSQSQGDAVAMEAEARGSPGGRVLMQELTLLPVEASLILSVVAAVLQLHSYR 235
Query: 276 ----DNPGVRR-HLVKKPSRTQGGRG 296
D P RR H + + GGRG
Sbjct: 236 RPAGDTPDPRRGHHRHRRRQRGGGRG 261
>gi|239750506 PREDICTED: hypothetical protein XP_002347417 [Homo
sapiens]
Length = 325
Score = 55.5 bits (132), Expect = 3e-07
Identities = 70/266 (26%), Positives = 98/266 (36%), Gaps = 47/266 (17%)
Query: 59 PEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAP 118
P P+ ++ R HT H T HP S+ PP H LPPT
Sbjct: 33 PANPAPFHTPRKRHPLSHTPHATAHPPSSP-PPLHITPVLPPTFP--------------- 76
Query: 119 PSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPP---PSGTPQKAKFSIGSDEDDS 175
GT P + A E ++EE ++ P+ PP G +GS
Sbjct: 77 ---GTQPPRALRLAEGSGEGKQEEGRRAQARPRPLRPPWEVRGGARGPCSAPVGSRASSG 133
Query: 176 PGLPGRAAV--TKPLPSVGPHTDKSPQHSSSS---PSPRARASRLAGEKSRPWSPSASYD 230
PGLP AA + + P + +SP +SS+ PR RL G RP SP+
Sbjct: 134 PGLPSAAAARPARKTLTCQPRSIESPATASSAGCGSGPRVPQVRLLGPGGRPSSPARDGS 193
Query: 231 LRER-------------LCPGSALGNPGGP--EQQVPTDEAEAQMLGSADLDDMKSHRLE 275
R+ A G+PGG Q++ EA ++ S ++ H
Sbjct: 194 RRKAGHGCTSQSQGDAVAMEAEARGSPGGRVLMQELTLLPVEASLILSVVAAVLQLHSYR 253
Query: 276 ----DNPGVRR-HLVKKPSRTQGGRG 296
D P RR H + + GGRG
Sbjct: 254 RPAGDTPDPRRGHHRHRRRQRGGGRG 279
>gi|239744803 PREDICTED: hypothetical protein XP_002343287 [Homo
sapiens]
Length = 325
Score = 55.5 bits (132), Expect = 3e-07
Identities = 70/266 (26%), Positives = 98/266 (36%), Gaps = 47/266 (17%)
Query: 59 PEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAP 118
P P+ ++ R HT H T HP S+ PP H LPPT
Sbjct: 33 PANPAPFHTPRKRHPLSHTPHATAHPPSSP-PPLHITPVLPPTFP--------------- 76
Query: 119 PSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPP---PSGTPQKAKFSIGSDEDDS 175
GT P + A E ++EE ++ P+ PP G +GS
Sbjct: 77 ---GTQPPRALRLAEGSGEGKQEEGRRAQARPRPLRPPWEVRGGARGPCSAPVGSRASSG 133
Query: 176 PGLPGRAAV--TKPLPSVGPHTDKSPQHSSSS---PSPRARASRLAGEKSRPWSPSASYD 230
PGLP AA + + P + +SP +SS+ PR RL G RP SP+
Sbjct: 134 PGLPSAAAARPARKTLTCQPRSIESPATASSAGCGSGPRVPQVRLLGPGGRPSSPARDGS 193
Query: 231 LRER-------------LCPGSALGNPGGP--EQQVPTDEAEAQMLGSADLDDMKSHRLE 275
R+ A G+PGG Q++ EA ++ S ++ H
Sbjct: 194 RRKAGHGCTSQSQGDAVAMEAEARGSPGGRVLMQELTLLPVEASLILSVVAAVLQLHSYR 253
Query: 276 ----DNPGVRR-HLVKKPSRTQGGRG 296
D P RR H + + GGRG
Sbjct: 254 RPAGDTPDPRRGHHRHRRRQRGGGRG 279
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 55.5 bits (132), Expect = 3e-07
Identities = 69/269 (25%), Positives = 92/269 (34%), Gaps = 59/269 (21%)
Query: 16 PQVRVPL-EEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFH 74
PQ+ PL EE PL P EE +S PP P P
Sbjct: 428 PQLEAPLNEEMPLLPPPEESP---------------LSPPPEESPTSPP----------- 461
Query: 75 RHTSHHTHHPLSARL-PPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEG--TPPIQEEGG 131
P ++RL PPP +L P A H R ++ S PP E +PP +
Sbjct: 462 ---------PEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPF 512
Query: 132 AGVDEEEEEEEEEEGESEA--EPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLP 189
+ ++E EE S A P+ PPP +P F ++SP P + P
Sbjct: 513 SPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPF------EESPLSPPPEELPTSPP 566
Query: 190 SVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQ 249
P+ S SP P E SR + P S L P PE+
Sbjct: 567 PEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEE----------SPLSPP--PEE 614
Query: 250 QVPTDEAEAQMLGSADLDDMKSHRLEDNP 278
+ EA L D S E++P
Sbjct: 615 SPLSPPPEASRLSPPPEDSPMSPPPEESP 643
Score = 53.9 bits (128), Expect = 9e-07
Identities = 66/248 (26%), Positives = 84/248 (33%), Gaps = 37/248 (14%)
Query: 6 IPPPGGASPLPQVRVPLEEPPLSPDVEE---EDDDLGKTLAVSRFGDLISKPPAWDPEKP 62
+ PP ASPL P EE PLSP EE L+ +S PP P P
Sbjct: 536 LSPPPEASPLSP---PFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSP 592
Query: 63 SRSYSER--DFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPP- 119
S FE + PLS PPP R PP ++ S PP
Sbjct: 593 PPEASRLFPPFEESPLSPPPEESPLS---PPPEASRLSPPPEDSPMSPPPEESPMSPPPE 649
Query: 120 ----------SEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIG 169
S +PP +E + EE E + P E P+ P + +
Sbjct: 650 VSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASP 709
Query: 170 SDEDDSPGLPGRAAVTKPLP--------SVGPHTDKSPQHSSSSP-------SPRARASR 214
ED LP + PLP S GPH P+ SP SP+A
Sbjct: 710 PPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPH 769
Query: 215 LAGEKSRP 222
L+ + P
Sbjct: 770 LSPQPEEP 777
Score = 32.0 bits (71), Expect = 3.7
Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 3/73 (4%)
Query: 109 KRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPV--EPPPSGTPQKAKF 166
+RK+ TS +G P I +E G++ + + E+G +A PV +P GTP +
Sbjct: 1813 ERKELPTSQKGDDG-PDIADEESRGLEGKADTPGPEDGGVKASPVPSDPEKPGTPGEGML 1871
Query: 167 SIGSDEDDSPGLP 179
S D + LP
Sbjct: 1872 SSDLDRISTEELP 1884
Score = 30.8 bits (68), Expect = 8.3
Identities = 62/247 (25%), Positives = 82/247 (33%), Gaps = 46/247 (18%)
Query: 16 PQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHR 75
P + EEP LSP EE L + + P P+ S + E H
Sbjct: 759 PHLSPQAEEPHLSPQPEEP------CLCA------VPEEPHLSPQAEGPHLSPQPEELHL 806
Query: 76 HTSHHTHH----PLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTP------- 124
H P L P + L P S R +E +P E P
Sbjct: 807 SPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEK 866
Query: 125 PIQEEGGAGVDEE--------EEEEEEEEGESE-AEPVEPPPSGTPQKAKFSIGSDEDDS 175
P +E G EE E GE +EP EPP S P++ S + S
Sbjct: 867 PPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLS 926
Query: 176 PGLPGRAAVTKPLPSVGPHTDKSPQHSSSSP---SPRARASRLAGEK--SRPWSPSASYD 230
P L + PL SP ++++P SP G K S P SP A+
Sbjct: 927 PQLMPPDPLPPPL---------SPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPI 977
Query: 231 LRERLCP 237
L + P
Sbjct: 978 LETPISP 984
>gi|239757043 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 996
Score = 52.0 bits (123), Expect = 3e-06
Identities = 75/337 (22%), Positives = 117/337 (34%), Gaps = 47/337 (13%)
Query: 62 PSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSE 121
P + + H H HH HHP PP L LPP + PP
Sbjct: 647 PHSAQTHPHHHHHPHHHHHHHHPPQ----PPSPLLLLPPQPDEPGSERHHPAPPPPPPPP 702
Query: 122 GTPPIQEE---------GGAGVD-EEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSD 171
PP+ + GG E+ E+E+ E E + V+ P+ + G D
Sbjct: 703 PPPPLAQHPHHRGLLSPGGTSCSYPSEDSSEDEDDEEEEQEVDVEGHKPPEGEEEEEGRD 762
Query: 172 EDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDL 231
DD V P VG + S S R RA +AG + P ++S L
Sbjct: 763 PDDDEEEDEETEVLLGDPLVGGGRFLQGRGPSEKGSSRDRAPAVAG--AFPLGLNSSRLL 820
Query: 232 RERLCPGSALGNPGG---PEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRH---LV 285
+E LG+PG P P +A GS+ +PG H L
Sbjct: 821 QE----DGKLGDPGSDLPPPPPPPLAPQKASGGGSS------------SPGSPVHHPSLE 864
Query: 286 KKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETA--- 342
++PS + + + + + H F+ + D S WRE +
Sbjct: 865 EQPSYKDSQKTKENNQVIVSTKDDNSFSDKNKEHSFFITDS----DASGGDFWRERSGEH 920
Query: 343 -RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTI 378
+ ++++ E GK + + F ++LRR +
Sbjct: 921 TQETNSPHSLKKDVENMGKEELQKVLFEQ-IDLRRRL 956
>gi|239751555 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 1252
Score = 51.2 bits (121), Expect = 6e-06
Identities = 74/337 (21%), Positives = 117/337 (34%), Gaps = 47/337 (13%)
Query: 62 PSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSE 121
P + + H H HH HHP PP L LPP + PP
Sbjct: 647 PHSAQTHPHHHHHPHHHHHHHHPPQ----PPSPLLLLPPQPDEPGSERHHPAPPPPPPPP 702
Query: 122 GTPPIQEE----------GGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSD 171
PP+ + G + E+ E+E+ E E + V+ P+ + G D
Sbjct: 703 PPPPLAQHPHHRGLLSPGGTSCCYPSEDSSEDEDDEEEEQEVDVEGHKPPEGEEEEEGRD 762
Query: 172 EDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDL 231
DD V P VG + S S R RA +AG + P ++S L
Sbjct: 763 PDDDEEEDEETEVLLGDPLVGGGRFLQGRGPSEKGSSRDRAPAVAG--AFPLGLNSSRLL 820
Query: 232 RERLCPGSALGNPGG---PEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRH---LV 285
+E LG+PG P P +A GS+ +PG H L
Sbjct: 821 QE----DGKLGDPGSDLPPPPPPPLAPQKASGGGSS------------SPGSPVHHPSLE 864
Query: 286 KKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETA--- 342
++PS + + + + + H F+ + D S WRE +
Sbjct: 865 EQPSYKDSQKTKENNQVIVSTKDDNSFSDKNKEHSFFITDS----DASGGDFWRERSGEH 920
Query: 343 -RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTI 378
+ ++++ E GK + + F ++LRR +
Sbjct: 921 TQETNSPHSLKKDVENMGKEELQKVLFEQ-IDLRRRL 956
>gi|239746067 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 1252
Score = 51.2 bits (121), Expect = 6e-06
Identities = 74/337 (21%), Positives = 117/337 (34%), Gaps = 47/337 (13%)
Query: 62 PSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSE 121
P + + H H HH HHP PP L LPP + PP
Sbjct: 647 PHSAQTHPHHHHHPHHHHHHHHPPQ----PPSPLLLLPPQPDEPGSERHHPAPPPPPPPP 702
Query: 122 GTPPIQEE----------GGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSD 171
PP+ + G + E+ E+E+ E E + V+ P+ + G D
Sbjct: 703 PPPPLAQHPHHRGLLSPGGTSCCYPSEDSSEDEDDEEEEQEVDVEGHKPPEGEEEEEGRD 762
Query: 172 EDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDL 231
DD V P VG + S S R RA +AG + P ++S L
Sbjct: 763 PDDDEEEDEETEVLLGDPLVGGGRFLQGRGPSEKGSSRDRAPAVAG--AFPLGLNSSRLL 820
Query: 232 RERLCPGSALGNPGG---PEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRH---LV 285
+E LG+PG P P +A GS+ +PG H L
Sbjct: 821 QE----DGKLGDPGSDLPPPPPPPLAPQKASGGGSS------------SPGSPVHHPSLE 864
Query: 286 KKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETA--- 342
++PS + + + + + H F+ + D S WRE +
Sbjct: 865 EQPSYKDSQKTKENNQVIVSTKDDNSFSDKNKEHSFFITDS----DASGGDFWRERSGEH 920
Query: 343 -RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTI 378
+ ++++ E GK + + F ++LRR +
Sbjct: 921 TQETNSPHSLKKDVENMGKEELQKVLFEQ-IDLRRRL 956
>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
[Homo sapiens]
Length = 517
Score = 48.5 bits (114), Expect = 4e-05
Identities = 63/230 (27%), Positives = 90/230 (39%), Gaps = 41/230 (17%)
Query: 118 PPSEGTPPIQEEGGAGVDEE----EEEEEEEEGESEAEPVEPPPSGTPQKAK----FSIG 169
P S+ P QEEG GVDE+ EE EEE+ E + E E + TPQ+ K S
Sbjct: 285 PESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEE 344
Query: 170 SDEDDSPGLPGRA--AVTKPLPSVGPHTDKSPQHSSS----------------SPSPRAR 211
SD + + A A+ P ++ P SS S + RA
Sbjct: 345 SDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAA 404
Query: 212 ASRLAGEKSRPWSPSASYDLRERLCPG----SALGNPGGPEQQVPTDEAEAQMLGSADLD 267
AS+L K P+A R RL G S P P + + + Q+ +
Sbjct: 405 ASKLEQGKRVSEMPAAK---RLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQV-----TE 456
Query: 268 DMKSHRLEDNPGVRRHLVKKPSRTQGGRGSP---SGLAPILRRKKKKKKL 314
D L P + L+KK + G S + LA IL+R ++K+
Sbjct: 457 DAVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERKM 506
Score = 33.9 bits (76), Expect = 0.98
Identities = 46/209 (22%), Positives = 84/209 (40%), Gaps = 24/209 (11%)
Query: 103 ARHTRRKRKKEKTSAPPSEGTPPIQEEGGAG---VDEEEEEEEEEEGESEAEPVEPPPSG 159
A+ R+K+KK+ + E + EG D +EE E +++A E P G
Sbjct: 241 AKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKG 300
Query: 160 TPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEK 219
+++ S S+E+ P K P+ +K + SS S + S + E
Sbjct: 301 VDEQSDSSEESEEEKPPEEDKEEEEEKKAPT---PQEKKRRKDSSEESDSSEESDIDSEA 357
Query: 220 SRPWSPSASYDLRERLCP--------GSALGN--PGGPEQQVPTDEAEAQMLGSADLDDM 269
S SA + +++ P GS+ GN PG P + + + L +A
Sbjct: 358 S-----SALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAE---GGSTSSTLRAAASKLE 409
Query: 270 KSHRLEDNPGVRRHLVKKPSRTQGGRGSP 298
+ R+ + P +R + ++ G+ +P
Sbjct: 410 QGKRVSEMPAAKRLRLDTGPQSLSGKSTP 438
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 47.0 bits (110), Expect = 1e-04
Identities = 41/117 (35%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 86 SARLP--PPHKLRRLPPTSARHTRRKRKKEKT---SAPPSEGTPPIQEEGGAGVDEEEEE 140
+A++P PP K PP ++ KT S P E T GGA +EEEEE
Sbjct: 970 AAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEE 1029
Query: 141 -EEEEEGESEAEPVEPPPSGTPQKAKF---SIGSDEDDSPGLPGRAAVTKPLPSVGP 193
EEEEE E E +P + T A S GS DS G A+ LP++ P
Sbjct: 1030 EEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLPTLPP 1086
Score = 38.9 bits (89), Expect = 0.031
Identities = 33/110 (30%), Positives = 46/110 (41%), Gaps = 11/110 (10%)
Query: 100 PTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSG 159
PT ++ ++K G+ P G +EEEEEEEEEE E E E E S
Sbjct: 233 PTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQ 292
Query: 160 TPQKAKFSIGSDEDD---SPGLPG------RAAVTKPLPSVG--PHTDKS 198
+ + ++ DD S PG A T+P P+ G P D +
Sbjct: 293 SISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDST 342
>gi|182507165 thymus expressed gene 3-like [Homo sapiens]
Length = 629
Score = 47.0 bits (110), Expect = 1e-04
Identities = 47/160 (29%), Positives = 65/160 (40%), Gaps = 7/160 (4%)
Query: 100 PTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSG 159
P SAR R + P S P A E E E + P + P G
Sbjct: 296 PGSARPAREPSLERVGGHPTS---PAALSRAWASSWESEAAPEPAAPPAAPSPPDSPAEG 352
Query: 160 TPQKAKFSIGSDEDDSPGLPGRAAVTKPLP-SVGPHTDKS-PQHSSSSPSPRARASRLAG 217
KA++ G+ + + GLPGRAA KP P + G ++S P+ + R R + +G
Sbjct: 353 RLVKAQYIPGA-QAATRGLPGRAARRKPPPLTRGRSVEQSPPRERPRAAGRRGRMAEASG 411
Query: 218 EKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAE 257
+ P + AS E G A P GP + PT E E
Sbjct: 412 RRGSPRARKASRSQSETSLLGRASAVPSGP-PKYPTAERE 450
Score = 34.7 bits (78), Expect = 0.58
Identities = 80/345 (23%), Positives = 113/345 (32%), Gaps = 43/345 (12%)
Query: 3 NGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLA-VSRFGDLISKPPAWDPEK 61
N V P ASP P P EP L + A S + + PA P
Sbjct: 283 NSVRQRPPDASPSPGSARPAREPSLERVGGHPTSPAALSRAWASSWESEAAPEPAAPPAA 342
Query: 62 PSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPP--TSARHTRRKRKKEKTSAPP 119
PS S + + + + R P RR PP T R + +E+ A
Sbjct: 343 PSPPDSPAEGRLVK-AQYIPGAQAATRGLPGRAARRKPPPLTRGRSVEQSPPRERPRAAG 401
Query: 120 SEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLP 179
G + G G + + S PSG P K+ E+ P P
Sbjct: 402 RRGR-MAEASGRRGSPRARKASRSQSETSLLGRASAVPSGPP---KYPTAEREEPRPPRP 457
Query: 180 GRAAVTKPLPSVGPHTDKSPQHSSSSPS----------PRARASRLAGEKSRPWSP---- 225
R P P++ S + S+ PRA A+R+ G P +P
Sbjct: 458 RRG----PAPTLAAQAAGSCRRWRSTAEIDAADGRRVRPRAPAARVPGPGPSPSAPQRRL 513
Query: 226 ------SASYDLRERLCPGSALGNPGG-----PEQQVPTDEAEAQMLGSADLDDMKSHRL 274
S S RL P G GG E + E E+ SA D S L
Sbjct: 514 LYGCAGSDSECSAGRLGPLGRRGPAGGVGGGYGESESSASEGESPAFSSASSDSDGSGGL 573
Query: 275 EDNPGVRRHLVKKPSRTQG--GRGSPSGLAPILRRKKKKKKLDRR 317
+ LV + + G G G+P+G A + + K L ++
Sbjct: 574 V----WPQQLVAATAASGGGAGAGAPAGPAKVFVKIKASHALKKK 614
>gi|4504733 insulin receptor substrate 4 [Homo sapiens]
Length = 1257
Score = 46.2 bits (108), Expect = 2e-04
Identities = 52/206 (25%), Positives = 80/206 (38%), Gaps = 33/206 (16%)
Query: 106 TRRKRKKEKTSAPPSEGTPPIQEEGGAG-----------VDEEEEEEEEEEGESEAEPVE 154
T+ K+++ PP PP GG G VD +E +E E + +
Sbjct: 620 TQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVDRGATKECKEAKEVKDAEIP 679
Query: 155 PPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASR 214
+ P +A+ + DEDD P +P R V PL S + +PQ+ S+S +R+
Sbjct: 680 EGAARGPHRAR-AFDEDEDD-PYVPMRPGVATPLVSSSDYMPMAPQNVSASKKRHSRS-- 735
Query: 215 LAGEKSRPWSPSASYDLR-ERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHR 273
P+ S Y + R+ P A P P+ D + +D +S
Sbjct: 736 -------PFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKD---------NDSESDY 779
Query: 274 LEDNPGVRRHLVKKPSRTQGGRGSPS 299
+ PG + K P QGG S S
Sbjct: 780 MFMAPGAGA-IPKNPRNPQGGSSSKS 804
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 46.2 bits (108), Expect = 2e-04
Identities = 58/266 (21%), Positives = 96/266 (36%), Gaps = 28/266 (10%)
Query: 60 EKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPP 119
+K + S D E P + + P K LPP A + E +S+
Sbjct: 76 KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA----AKASESSSSEE 131
Query: 120 SEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLP 179
S D++EE+++++ + +P P+KAK S + S P
Sbjct: 132 SSD------------DDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP 179
Query: 180 GRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGS 239
+ K P K+P + + +P+ + A S S S+S D E +
Sbjct: 180 PKNQKPKITPVTVKAQTKAPPKPARA-APKIANGKAASSSSSSSSSSSSDDSEEEKAAAT 238
Query: 240 ALGNPGGPEQQVPTDEAEAQM-LGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSP 298
P++ VP + A+ + +A KS ED+ KKP + + G P
Sbjct: 239 -------PKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPG---P 288
Query: 299 SGLAPILRRKKKKKKLDRRPHEVFVE 324
P KK L +P + VE
Sbjct: 289 YSSVPPPSAPPPKKSLGTQPPKKAVE 314
Score = 33.5 bits (75), Expect = 1.3
Identities = 29/125 (23%), Positives = 52/125 (41%), Gaps = 14/125 (11%)
Query: 109 KRKKEKTSAPPSEGTPPIQEEGGA-------GVDEEEEEEEEEEGESEAEPVEPPPSG-- 159
K+K +K + + P ++G A D EEEEE+ +G+ P P +G
Sbjct: 491 KKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTS 550
Query: 160 --TPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAG 217
T Q K + S+E++ V+K S K + + + +P+A+ +L
Sbjct: 551 ALTAQNGKAAKNSEEEEEEKKKAAVVVSK---SGSLKKRKQNEAAKEAETPQAKKIKLQT 607
Query: 218 EKSRP 222
+ P
Sbjct: 608 PNTFP 612
Score = 31.6 bits (70), Expect = 4.9
Identities = 66/325 (20%), Positives = 101/325 (31%), Gaps = 54/325 (16%)
Query: 28 SPDVEEEDDDL----GKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHH 83
S D EE++++ K AV + PP K S S S +
Sbjct: 87 SEDSSEEEEEVQGPPAKKAAVP--AKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQ 144
Query: 84 PLSARLPPPHKLRRLPPTSARHT--------------RRKRK------KEKTSAP--PSE 121
P+ + P K + PP A+ + +K K K +T AP P+
Sbjct: 145 PVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPAR 204
Query: 122 GTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQK---AKFSI---------- 168
P I A + E + P P+K AK +
Sbjct: 205 AAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKS 264
Query: 169 ------GSDEDDSPGLPGRAAVTKPLP--SVGPHTDKSPQHS-SSSPSPRARASRLAGEK 219
SDE++ P + KP P SV P + P+ S + P +A + E
Sbjct: 265 SSSEDSSSDEEEEQKKPMK---NKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVES 321
Query: 220 SRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNP- 278
S S + E P + + P +A S+D D + P
Sbjct: 322 SEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPA 381
Query: 279 GVRRHLVKKPSRTQGGRGSPSGLAP 303
G ++ KP+ T AP
Sbjct: 382 GTTKNSSNKPAVTTKSPAVKPAAAP 406
Score = 31.6 bits (70), Expect = 4.9
Identities = 26/102 (25%), Positives = 44/102 (43%), Gaps = 8/102 (7%)
Query: 114 KTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDED 173
+ AP + GT + + G EEEEEE++ + V SG+ +K K + + E
Sbjct: 540 RPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAA----VVVSKSGSLKKRKQNEAAKEA 595
Query: 174 DSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRL 215
++ P + P+ P K + +SSP R R +
Sbjct: 596 ET---PQAKKIKLQTPNTFPKRKKG-EKRASSPFRRVREEEI 633
Score = 31.2 bits (69), Expect = 6.4
Identities = 53/245 (21%), Positives = 91/245 (37%), Gaps = 33/245 (13%)
Query: 106 TRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAK 165
T+ K + + P++ P + + D EEEEE+ A +P QK
Sbjct: 445 TKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKP------QK-- 496
Query: 166 FSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKS-RPWS 224
+ G AA +KP S +S SSS S +L G+ S RP +
Sbjct: 497 ------------VAGGAAPSKP-ASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQA 543
Query: 225 PSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSH---RLEDNPGVR 281
P A+ G A N E++ +A + S L K + + + P +
Sbjct: 544 PKANGTSALTAQNGKAAKN--SEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAK 601
Query: 282 RHLVKKPSR-TQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRE 340
+ ++ P+ + +G +P R ++++ ++D R V N R W E
Sbjct: 602 KIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSR-----VADNSFDAKRGAAGDWGE 656
Query: 341 TARWI 345
A +
Sbjct: 657 RANQV 661
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 46.2 bits (108), Expect = 2e-04
Identities = 57/242 (23%), Positives = 83/242 (34%), Gaps = 29/242 (11%)
Query: 8 PPGGASPLPQVRVPLEEPPLSPDV-------EEEDDDLGKTLAVSRFGDLISKPPAWDPE 60
P G SP P R P P + E+E L + ++ + L + P A
Sbjct: 394 PNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSA 453
Query: 61 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPP-------TSARHTRRKRKKE 113
+ S + S H P S P P LPP T+A R R+KE
Sbjct: 454 STASELSPKSKARPSSPSTSWHRPASP-CPSPGPGHTLPPKPPSPRGTTASPKGRVRRKE 512
Query: 114 KTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESE-AEPVEPPPSGTPQKAKFSIGSDE 172
+ PS AG +++ + + E E A P P PS P ++
Sbjct: 513 EAKESPS----------AAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQ 562
Query: 173 DDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDLR 232
+ A +T P P T P + + R A+RL EK R + +
Sbjct: 563 PPAETPTDAAVLTSPPAPAPPVTPSKPM---AGTTDREEATRLLAEKRRQAREQREREEQ 619
Query: 233 ER 234
ER
Sbjct: 620 ER 621
Score = 37.0 bits (84), Expect = 0.12
Identities = 61/292 (20%), Positives = 104/292 (35%), Gaps = 47/292 (16%)
Query: 95 LRRLPPTSARHTRRKRKKEKTSAPPSEGTP-PIQEEGGAG-VDEEEEEEEEEEGESEAEP 152
+ R P R RRK P + G+P P++ A V ++E++++E E E E
Sbjct: 379 VHRCAPAGERGERRK--------PNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSA 430
Query: 153 VEPPPS-------GTPQKAKFSIGSDEDDSPGLPGRAAV--------TKPLPSVGP-HT- 195
+ S +A+ S + + SP R + P PS GP HT
Sbjct: 431 LARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTL 490
Query: 196 ---DKSPQHSSSSPSPRAR-------ASRLAGEKSRPWSPSASYDLRERLCPGSALGNPG 245
SP+ +++SP R R + AG + + S + + +E P S +P
Sbjct: 491 PPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPA 550
Query: 246 GPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPIL 305
P + + D + S P PS+ G +L
Sbjct: 551 PSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPP-------VTPSKPMAGTTDREEATRLL 603
Query: 306 RRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETER 357
K+++ + R E + L +R + + AR + + E E R
Sbjct: 604 AEKRRQAREQREREE---QERRLQAERDKRMREEQLAREAEARAEREAEARR 652
>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
sapiens]
Length = 2462
Score = 45.4 bits (106), Expect = 3e-04
Identities = 53/193 (27%), Positives = 78/193 (40%), Gaps = 18/193 (9%)
Query: 93 HKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEE-----GGAGVDEEEEEEEEEEGE 147
HKL+ R+ RRK+KK +A PP+ E+ G +EEE EE E
Sbjct: 669 HKLKM---EKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATV 725
Query: 148 SEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPS 207
+ + E PS + AK G + P G P+ P +P + P+
Sbjct: 726 NNSSDTESIPSPHTEAAK-DTGQNGPKPPATLGADGPPPGPPTPPPEDIPAP----TEPT 780
Query: 208 PRARASRLAGEKSRPWSPSASYDL--RERLCPGSALGNP--GGPEQQVPTDEAEAQMLGS 263
P + A+ P SPSA + +E +A P G EQ+ P E A G
Sbjct: 781 PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 840
Query: 264 ADLDDMKSHRLED 276
A+ + +KS E+
Sbjct: 841 AE-EPVKSECTEE 852
Score = 35.0 bits (79), Expect = 0.44
Identities = 57/243 (23%), Positives = 82/243 (33%), Gaps = 38/243 (15%)
Query: 82 HHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQ----EEGGAGVDEE 137
HHP P P L P S +R PP + P + EGG E
Sbjct: 2141 HHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEP 2200
Query: 138 EEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTD- 196
+ GE EPV PP T PG R+AV L G T+
Sbjct: 2201 NKTSVLGGGEDGIEPVSPPEGMT--------------EPG-HSRSAVYPLLYRDGEQTEP 2245
Query: 197 -----KSPQHSSSSPS--PRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQ 249
KSP ++S P+ + S A KS+ + + R P + PG
Sbjct: 2246 SRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPG---- 2301
Query: 250 QVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHL---VKKPSRTQGGRGSPSGLAPILR 306
T+ + L +S ++++ L ++K GG+ SG P R
Sbjct: 2302 ---TEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKALMGGGGKAKVSG-RPSSR 2357
Query: 307 RKK 309
+ K
Sbjct: 2358 KAK 2360
Score = 33.1 bits (74), Expect = 1.7
Identities = 55/237 (23%), Positives = 81/237 (34%), Gaps = 28/237 (11%)
Query: 85 LSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEE- 143
L A PPP P T E T AP PP V +EE+EEE
Sbjct: 756 LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETA 815
Query: 144 -----EEGESEAEP------VEPPPSGTPQKAKFSIGSDEDDSPGLPGRAA------VTK 186
EEGE + P V+ + P K++ + ++E + G AA K
Sbjct: 816 AAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALK 875
Query: 187 PLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGG 246
G + SS +P ++ + ++ + D L P +L P G
Sbjct: 876 AEKKEGGSGRATTAKSSGAPQDSDSSATCSADEV---DEAEGGDKNRLLSPRPSLLTPTG 932
Query: 247 PEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAP 303
+ A A DL +K R P ++ V +P R P+ AP
Sbjct: 933 DPR------ANASPQKPLDLKQLK-QRAAAIPPIQVTKVHEPPREDAAPTKPAPPAP 982
Score = 30.8 bits (68), Expect = 8.3
Identities = 21/91 (23%), Positives = 32/91 (35%), Gaps = 4/91 (4%)
Query: 128 EEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKP 187
++ A + + + E +A P +P P P SD PG R P
Sbjct: 950 KQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSP 1009
Query: 188 LPSVGPHTDKSPQHSSSSPSPRARASRLAGE 218
P DK + P+ A A +L G+
Sbjct: 1010 ----APPADKEAEKPVFFPAFAAEAQKLPGD 1036
>gi|151101459 SAPS domain family, member 1 [Homo sapiens]
Length = 881
Score = 45.4 bits (106), Expect = 3e-04
Identities = 57/199 (28%), Positives = 74/199 (37%), Gaps = 24/199 (12%)
Query: 122 GTPPIQEEGGAGVDEEEEEEEEEEGESE----------AEPVE-----PPPSGTPQKAKF 166
G PP GG+ E+EEEE+EEE E E A P+ P P G A F
Sbjct: 657 GQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATF 716
Query: 167 S-IGSDEDDSPGLPGRAAV-TKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWS 224
+ +D SP + G + T P GP + + S SP AR L P
Sbjct: 717 DPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPAR-DALQLRSQDPTP 775
Query: 225 PSASYDLRERLCPGSALGNPGGPEQQ-VPTDEAEAQMLGSADLDDMKSHRLED-NPGVRR 282
PSA + E GS + P P Q V + +A G D + V
Sbjct: 776 PSAPQEATE----GSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPA 831
Query: 283 HLVKKPSRTQGGRGSPSGL 301
+P +T G SP L
Sbjct: 832 SGAHQPPQTTEGEKSPEPL 850
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.137 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,972,904
Number of Sequences: 37866
Number of extensions: 3066508
Number of successful extensions: 31153
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 259
Number of HSP's successfully gapped in prelim test: 828
Number of HSP's that attempted gapping in prelim test: 21008
Number of HSP's gapped (non-prelim): 6662
length of query: 1232
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1118
effective length of database: 13,930,794
effective search space: 15574627692
effective search space used: 15574627692
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.