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Search of human proteins with 157653329
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157653329 procollagen C-endopeptidase enhancer [Homo
sapiens]
(449 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens] 929 0.0
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens] 384 e-106
gi|22547221 tolloid-like 1 [Homo sapiens] 169 4e-42
gi|6912724 tolloid-like 2 [Homo sapiens] 169 6e-42
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 165 7e-41
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 165 9e-41
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 164 2e-40
gi|72384339 CUB domain containing protein 2 [Homo sapiens] 154 1e-37
gi|66864913 neuropilin 1 isoform c [Homo sapiens] 151 1e-36
gi|66912178 neuropilin 1 isoform b [Homo sapiens] 151 1e-36
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 151 1e-36
gi|126091152 cubilin [Homo sapiens] 148 9e-36
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 140 2e-33
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 140 2e-33
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 140 2e-33
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens] 140 2e-33
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 140 2e-33
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 140 2e-33
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 134 2e-31
gi|13899255 membrane frizzled-related protein [Homo sapiens] 130 2e-30
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 119 7e-27
gi|30520377 CUB and zona pellucida-like domains 1 [Homo sapiens] 108 8e-24
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 102 9e-22
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 102 9e-22
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 102 9e-22
gi|148231605 ovochymase 2 [Homo sapiens] 94 3e-19
gi|11415040 matriptase [Homo sapiens] 92 7e-19
gi|110815798 ovochymase 1 [Homo sapiens] 88 1e-17
gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [H... 85 1e-16
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr... 85 1e-16
>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
Length = 449
Score = 929 bits (2400), Expect = 0.0
Identities = 449/449 (100%), Positives = 449/449 (100%)
Query: 1 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPN 60
MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPN
Sbjct: 1 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPN 60
Query: 61 KECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPL 120
KECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPL
Sbjct: 61 KECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPL 120
Query: 121 VAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDY 180
VAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDY
Sbjct: 121 VAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDY 180
Query: 181 PPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAV 240
PPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAV
Sbjct: 181 PPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAV 240
Query: 241 PGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKS 300
PGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKS
Sbjct: 241 PGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKS 300
Query: 301 QPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAVTVSL 360
QPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAVTVSL
Sbjct: 301 QPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAVTVSL 360
Query: 361 IGAYKTGGLDLPSPPTGASLKFYVPCKQCPPMKKGVSYLLMGQVEENRGPVLPPESFVVL 420
IGAYKTGGLDLPSPPTGASLKFYVPCKQCPPMKKGVSYLLMGQVEENRGPVLPPESFVVL
Sbjct: 361 IGAYKTGGLDLPSPPTGASLKFYVPCKQCPPMKKGVSYLLMGQVEENRGPVLPPESFVVL 420
Query: 421 HRPNQDQILTNLSKRKCPSQPVRAAASQD 449
HRPNQDQILTNLSKRKCPSQPVRAAASQD
Sbjct: 421 HRPNQDQILTNLSKRKCPSQPVRAAASQD 449
>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
Length = 415
Score = 384 bits (985), Expect = e-106
Identities = 194/436 (44%), Positives = 272/436 (62%), Gaps = 29/436 (6%)
Query: 7 ASLLGPL-LTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIW 65
A+ PL L A ++ Q+P RPVF CGG + GESG++ SEGFP +YPPN +C W
Sbjct: 4 ANAWAPLCLLLAAATQLSRQQSPE--RPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTW 61
Query: 66 TITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGN 125
ITVPEG+ V L+FR DLE CRYD ++V+ G +GQR+GRFCGTFRP LV+ GN
Sbjct: 62 KITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGN 120
Query: 126 QVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGIS 185
++ ++M +D T G GF+ +S + Q+CGG L++ G+ TPNWP+ DYP G++
Sbjct: 121 KMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVT 180
Query: 186 CSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSIS 245
C WHI+AP +Q+I L FEKFD+E D YCRYD V+VFNG +D+RR+GK+CGD+ P I
Sbjct: 181 CVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIV 240
Query: 246 SEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKSQPPEK 305
SE NELL+QF+SDLS+TADGF Y P+ KLP ++ P
Sbjct: 241 SERNELLIQFLSDLSLTADGFIGHYIFRPK-------------------KLPTTTEQPVT 281
Query: 306 TEESPSAPDAPT---CPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAVTVSLIG 362
T + PT C ++CRRTGTL+ N+C+S V+ TV + + G L TVS+I
Sbjct: 282 TTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSDFVLAGTVITTITRDG-SLHATVSIIN 340
Query: 363 AYKTGGLDLPSPPTGASLKFYVPCKQCPPMKKGVSYLLMGQV-EENRGPVLPPESFVVLH 421
YK G L + S + V CKQCP +++G++Y++MGQV E+ RG ++ P SF+++
Sbjct: 341 IYKEGNLAIQQAGKNMSARLTVVCKQCPLLRRGLNYIIMGQVGEDGRGKIM-PNSFIMMF 399
Query: 422 RPNQDQILTNLSKRKC 437
+ ++L L ++C
Sbjct: 400 KTKNQKLLDALKNKQC 415
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 169 bits (429), Expect = 4e-42
Identities = 92/269 (34%), Positives = 139/269 (51%), Gaps = 36/269 (13%)
Query: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
+CGG+++ G + S +P+ Y P KEC+W ITV E V L+F+ F++E H C YD L
Sbjct: 461 ICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYL 520
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF------------- 142
EV G+ + +GRFCG +P + + N + ++ +D GF
Sbjct: 521 EVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK 580
Query: 143 -------------LLWYSGRATSGTE--------HQFCGGRLEKAQGTLTTPNWPESDYP 181
L Y G E CGG L K GT+TTP WP+ +YP
Sbjct: 581 PDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPK-EYP 639
Query: 182 PGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVP 241
P +C W ++AP I++ FE F+LE + C+YD V +++G +S +S+ GKFCG VP
Sbjct: 640 PNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSG-LSSESKLHGKFCGAEVP 698
Query: 242 GSISSEGNELLVQFVSDLSVTADGFSASY 270
I+S+ N + ++F SD +V+ GF A +
Sbjct: 699 EVITSQFNNMRIEFKSDNTVSKKGFKAHF 727
Score = 155 bits (391), Expect = 9e-38
Identities = 82/282 (29%), Positives = 134/282 (47%), Gaps = 36/282 (12%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG + +G + + G+P YPPNK C+W + P +S+ F F+LE + C+YD +E
Sbjct: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY------SGRA 150
+++G + + G+FCG P + + N + + +D +GF + +
Sbjct: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKD 737
Query: 151 TSGTEHQF----------------------------CGGRLEKAQGTLTTPNWPESDYPP 182
G +H+ C ++ G +T+PNWP+ YP
Sbjct: 738 NGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDK-YPS 796
Query: 183 GISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242
C+W I A P I L F +F++E C YD + VF+G ++ S LG+ CG+ +P
Sbjct: 797 RKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGE-TEKSPILGRLCGNKIPD 855
Query: 243 SISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGP 284
+ + GN++ V+FVSD SV GF A++ T G K P
Sbjct: 856 PLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKP 897
Score = 154 bits (390), Expect = 1e-37
Identities = 82/240 (34%), Positives = 127/240 (52%), Gaps = 13/240 (5%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
C + SG + S +P+ YP KEC W I+ G + L+F F++E H C YD LE
Sbjct: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
VF G LGR CG P PLVA GN++ +R +D +GF +AT TE
Sbjct: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGF------QATHSTE- 886
Query: 157 QFCGGRLE---KAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYC 213
CGGRL+ K + + + +++YP + C W +++ + L+F+ F++E + C
Sbjct: 887 --CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADC 944
Query: 214 RYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTL 273
YD V +F+G + + LG+FCG P I S G+ +L+ F +D ++ GF YK++
Sbjct: 945 GYDYVELFDG-LDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003
Score = 147 bits (370), Expect = 2e-35
Identities = 83/247 (33%), Positives = 124/247 (50%), Gaps = 11/247 (4%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CG ++ +G ++S GFPN YP CIW ++V G+ + L+F DL C YD +E
Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
V G LGRFCG P L + +++ + + G+GF Y
Sbjct: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA-------- 460
Query: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
CGG + K +G + +PN+P+ DY P C W I + LTF+ F++E C YD
Sbjct: 461 -ICGGEIRKNEGQIQSPNYPD-DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
Query: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276
+ V +G S++S +G+FCG P I S N L ++FVSD +V GF+A++
Sbjct: 519 YLEVRDG-TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDE 577
Query: 277 TAKEGQG 283
AK +G
Sbjct: 578 CAKPDRG 584
Score = 73.9 bits (180), Expect = 3e-13
Identities = 40/124 (32%), Positives = 61/124 (49%), Gaps = 4/124 (3%)
Query: 37 CGGDVKGESG----YVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRY 92
CGG +K ES Y ++ N YP +C W + G + LSF+ F++E C Y
Sbjct: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
Query: 93 DALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATS 152
D +E+F G ++ LGRFCG+ P + + G+ V + TD+ +GF + Y
Sbjct: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYP 1006
Query: 153 GTEH 156
T H
Sbjct: 1007 DTTH 1010
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 169 bits (427), Expect = 6e-42
Identities = 94/281 (33%), Positives = 144/281 (51%), Gaps = 36/281 (12%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGGD+ ++G + S +P+ Y P+KEC+W ITV EG V L+F+ F++E H +C YD LE
Sbjct: 464 CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLE 523
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY-------SGR 149
V G +G FCG +P + + N++ ++ +D GF + S
Sbjct: 524 VRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWP 583
Query: 150 ATSGTEHQF---------------------------CGGRLEKAQGTLTTPNWPESDYPP 182
G EH+ CGG + K GT+T+P WP+ +YP
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPK-EYPT 642
Query: 183 GISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242
+C W ++AP I+L FE F+LE + C+YD V V +G +S D++ G+FCG P
Sbjct: 643 NKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSG-LSPDAKLHGRFCGSETPE 701
Query: 243 SISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQG 283
I+S+ N + V+F SD +V+ GF A + + AK+ G
Sbjct: 702 VITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGG 742
Score = 147 bits (370), Expect = 2e-35
Identities = 81/277 (29%), Positives = 128/277 (46%), Gaps = 36/277 (12%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG + +G + S G+P YP NK C+W + P +SL F VF+LE + C+YD +E
Sbjct: 620 CGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVE 679
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY------SGRA 150
V +G + GRFCG+ P + + N + + +D RGF + +
Sbjct: 680 VRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKD 739
Query: 151 TSGTEHQF----------------------------CGGRLEKAQGTLTTPNWPESDYPP 182
G +H+ C ++ +GTL +PNWP+ YP
Sbjct: 740 NGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDK-YPS 798
Query: 183 GISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242
C+W+I + + LTF +F++E C YD + +++G S + LG+FCG P
Sbjct: 799 RRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSL-APILGRFCGSKKPD 857
Query: 243 SISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAK 279
+ G+ + ++F SD SV GF A + T G K
Sbjct: 858 PTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLK 894
Score = 146 bits (369), Expect = 3e-35
Identities = 79/237 (33%), Positives = 123/237 (51%), Gaps = 13/237 (5%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
C + G +AS +P+ YP +EC W I+ G V L+F F++E H C YD LE
Sbjct: 776 CAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLE 835
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
++ G + LGRFCG+ +P P VA G+ + LR +D +GF +A TE
Sbjct: 836 MYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGF------QAVHSTE- 888
Query: 157 QFCGGRLE---KAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYC 213
CGGRL+ + + + + +++YP C W I+A + LTF F++E + C
Sbjct: 889 --CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADC 946
Query: 214 RYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
YD + ++G + RLG+FCG I S G+ L+++F +D ++ GF A Y
Sbjct: 947 GYDYMEAYDG-YDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002
Score = 145 bits (366), Expect = 7e-35
Identities = 79/234 (33%), Positives = 119/234 (50%), Gaps = 11/234 (4%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CG ++ +G ++ GFPN YP C+W I+V G+ + L+F DL C YD +E
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
V G LGRFCG P PLV+ +++ + + G+GF Y
Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEAT------- 463
Query: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
CGG + K G + +PN+P+ DY P C W I + LTF+ F++E C YD
Sbjct: 464 --CGGDMNKDAGQIQSPNYPD-DYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYD 520
Query: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
+ V +G +++S +G FCG P + S N L ++FVSD S+ GF+A++
Sbjct: 521 YLEVRDGP-TEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF 573
Score = 73.9 bits (180), Expect = 3e-13
Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 4/115 (3%)
Query: 37 CGGDVKGESG----YVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRY 92
CGG +K E Y ++ N YP C W I +G V L+FR F++E C Y
Sbjct: 889 CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGY 948
Query: 93 DALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS 147
D +E + G +S RLGRFCG+ + + G+ + +R TD+ +GF Y+
Sbjct: 949 DYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYT 1003
Score = 70.5 bits (171), Expect = 3e-12
Identities = 41/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CG L+ G + P +P YP C W I P + I L F DL C YD V
Sbjct: 351 CGETLQDTTGNFSAPGFPNG-YPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYV 409
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278
V +G + LG+FCGD +P + S + L V+F S ++ GF A+Y+ G
Sbjct: 410 EVRDGYWRK-APLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDM 468
Query: 279 KEGQG 283
+ G
Sbjct: 469 NKDAG 473
>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
sapiens]
Length = 730
Score = 165 bits (418), Expect = 7e-41
Identities = 97/303 (32%), Positives = 156/303 (51%), Gaps = 40/303 (13%)
Query: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
+CGGDVK + G++ S +P+ Y P+K CIW I V EG V L+F+ F++E H +C YD L
Sbjct: 434 ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY-------SG 148
EV G S +GR+CG +P + + +++ L+ +D GF + + S
Sbjct: 494 EVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
Query: 149 RATSGTEHQF---------------------------CGGRLEKAQGTLTTPNWPESDYP 181
G E + CGG L K G++T+P WP+ +YP
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK-EYP 612
Query: 182 PGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVP 241
P +C W ++AP I+L F+ F+ E + C+YD V V +G ++ DS+ GKFCG P
Sbjct: 613 PNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG-LTADSKLHGKFCGSEKP 671
Query: 242 GSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKSQ 301
I+S+ N + V+F SD +V+ GF A + + R + +G R + K ++ +++
Sbjct: 672 EVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG----RPHQLKFRVQKRNR 727
Query: 302 PPE 304
P+
Sbjct: 728 TPQ 730
Score = 134 bits (338), Expect = 1e-31
Identities = 74/234 (31%), Positives = 118/234 (50%), Gaps = 11/234 (4%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CG ++ +G +S +PN Y + C+W I+V G+ + L+F DL C YD +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
V G GRFCG+ P P+V+ +++ + + G+GF Y
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-------- 433
Query: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
CGG ++K G + +PN+P+ DY P C W I + LTF+ F++E C YD
Sbjct: 434 -ICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
Query: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
+ V +G S+ S +G++CG P I S + L ++FVSD S+ GF+ ++
Sbjct: 492 YLEVRDGH-SESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
Score = 82.0 bits (201), Expect = 1e-15
Identities = 38/115 (33%), Positives = 60/115 (52%)
Query: 28 PNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELH 87
P+ R CGG + +G + S G+P YPPNK CIW + P +SL F F+ E +
Sbjct: 582 PDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN 641
Query: 88 PACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF 142
C+YD +EV +G + G+FCG+ +P + + N + + +D +GF
Sbjct: 642 DVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
Score = 67.4 bits (163), Expect = 3e-11
Identities = 41/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CG L+ + G ++P +P Y + C W I P + I L F DL C YD V
Sbjct: 322 CGETLQDSTGNFSSPEYPNG-YSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278
V +G R G+FCG +P I S + L V+F S + GF A Y+ + G
Sbjct: 381 EVRDGFWRKAPLR-GRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV 439
Query: 279 KEGQG 283
K+ G
Sbjct: 440 KKDYG 444
>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
sapiens]
Length = 823
Score = 165 bits (417), Expect = 9e-41
Identities = 93/275 (33%), Positives = 144/275 (52%), Gaps = 36/275 (13%)
Query: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
+CGGDVK + G++ S +P+ Y P+K CIW I V EG V L+F+ F++E H +C YD L
Sbjct: 434 ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY-------SG 148
EV G S +GR+CG +P + + +++ L+ +D GF + + S
Sbjct: 494 EVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
Query: 149 RATSGTEHQF---------------------------CGGRLEKAQGTLTTPNWPESDYP 181
G E + CGG L K G++T+P WP+ +YP
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK-EYP 612
Query: 182 PGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVP 241
P +C W ++AP I+L F+ F+ E + C+YD V V +G ++ DS+ GKFCG P
Sbjct: 613 PNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG-LTADSKLHGKFCGSEKP 671
Query: 242 GSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276
I+S+ N + V+F SD +V+ GF A + ++ G
Sbjct: 672 EVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEG 706
Score = 134 bits (338), Expect = 1e-31
Identities = 74/234 (31%), Positives = 118/234 (50%), Gaps = 11/234 (4%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CG ++ +G +S +PN Y + C+W I+V G+ + L+F DL C YD +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
V G GRFCG+ P P+V+ +++ + + G+GF Y
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-------- 433
Query: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
CGG ++K G + +PN+P+ DY P C W I + LTF+ F++E C YD
Sbjct: 434 -ICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
Query: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
+ V +G S+ S +G++CG P I S + L ++FVSD S+ GF+ ++
Sbjct: 492 YLEVRDGH-SESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
Score = 83.2 bits (204), Expect = 4e-16
Identities = 42/135 (31%), Positives = 67/135 (49%), Gaps = 1/135 (0%)
Query: 28 PNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELH 87
P+ R CGG + +G + S G+P YPPNK CIW + P +SL F F+ E +
Sbjct: 582 PDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN 641
Query: 88 PACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLL-WY 146
C+YD +EV +G + G+FCG+ +P + + N + + +D +GF ++
Sbjct: 642 DVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701
Query: 147 SGRATSGTEHQFCGG 161
S +G H G
Sbjct: 702 SVLEGAGDRHSHLSG 716
Score = 67.4 bits (163), Expect = 3e-11
Identities = 41/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CG L+ + G ++P +P Y + C W I P + I L F DL C YD V
Sbjct: 322 CGETLQDSTGNFSSPEYPNG-YSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278
V +G R G+FCG +P I S + L V+F S + GF A Y+ + G
Sbjct: 381 EVRDGFWRKAPLR-GRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV 439
Query: 279 KEGQG 283
K+ G
Sbjct: 440 KKDYG 444
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 164 bits (415), Expect = 2e-40
Identities = 92/269 (34%), Positives = 141/269 (52%), Gaps = 36/269 (13%)
Query: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
+CGGDVK + G++ S +P+ Y P+K CIW I V EG V L+F+ F++E H +C YD L
Sbjct: 434 ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY-------SG 148
EV G S +GR+CG +P + + +++ L+ +D GF + + S
Sbjct: 494 EVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
Query: 149 RATSGTEHQF---------------------------CGGRLEKAQGTLTTPNWPESDYP 181
G E + CGG L K G++T+P WP+ +YP
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK-EYP 612
Query: 182 PGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVP 241
P +C W ++AP I+L F+ F+ E + C+YD V V +G ++ DS+ GKFCG P
Sbjct: 613 PNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG-LTADSKLHGKFCGSEKP 671
Query: 242 GSISSEGNELLVQFVSDLSVTADGFSASY 270
I+S+ N + V+F SD +V+ GF A +
Sbjct: 672 EVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 160 bits (404), Expect = 3e-39
Identities = 84/237 (35%), Positives = 128/237 (54%), Gaps = 13/237 (5%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
C V SG + S +P+ YP KEC W I+ G V L+F D+E P C YD LE
Sbjct: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
VF G LGRFCG+ +P P++A G+++ LR +D +GF +A+ TE
Sbjct: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGF------QASHATE- 859
Query: 157 QFCGGRLE---KAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYC 213
CGG++ K + + + +++YP G+ C W I+A + L F+ F++E +T C
Sbjct: 860 --CGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDC 917
Query: 214 RYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
YD + +F+G + RLG++CG P + S G+ +LV+F SD ++T GF Y
Sbjct: 918 GYDYMELFDG-YDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
Score = 145 bits (366), Expect = 7e-35
Identities = 83/279 (29%), Positives = 129/279 (46%), Gaps = 36/279 (12%)
Query: 28 PNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELH 87
P+ R CGG + +G + S G+P YPPNK CIW + P +SL F F+ E +
Sbjct: 582 PDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN 641
Query: 88 PACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY- 146
C+YD +EV +G + G+FCG+ +P + + N + + +D +GF +
Sbjct: 642 DVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701
Query: 147 -----------------------------SGRATSGTEHQF----CGGRLEKAQGTLTTP 173
SG +H C ++ GT+T+P
Sbjct: 702 SDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSP 761
Query: 174 NWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLG 233
NWP+ YP C+W I + P + LTF + D+E C YD + VF+G + + LG
Sbjct: 762 NWPDK-YPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAK-APVLG 819
Query: 234 KFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKT 272
+FCG P + + G+ + ++F SD SV GF AS+ T
Sbjct: 820 RFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHAT 858
Score = 134 bits (338), Expect = 1e-31
Identities = 74/234 (31%), Positives = 118/234 (50%), Gaps = 11/234 (4%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CG ++ +G +S +PN Y + C+W I+V G+ + L+F DL C YD +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
V G GRFCG+ P P+V+ +++ + + G+GF Y
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-------- 433
Query: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
CGG ++K G + +PN+P+ DY P C W I + LTF+ F++E C YD
Sbjct: 434 -ICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
Query: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
+ V +G S+ S +G++CG P I S + L ++FVSD S+ GF+ ++
Sbjct: 492 YLEVRDGH-SESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
Score = 77.8 bits (190), Expect = 2e-14
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 37 CGG----DVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRY 92
CGG DVK + Y ++ N YP +C W I EG V L F+ F++E C Y
Sbjct: 860 CGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGY 919
Query: 93 DALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATS 152
D +E+F G ++ RLGR+CG+ P + + G+ V ++ +D+ +GF L Y+
Sbjct: 920 DYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQ 979
Query: 153 GTEH 156
T H
Sbjct: 980 DTLH 983
Score = 67.4 bits (163), Expect = 3e-11
Identities = 41/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CG L+ + G ++P +P Y + C W I P + I L F DL C YD V
Sbjct: 322 CGETLQDSTGNFSSPEYPNG-YSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278
V +G R G+FCG +P I S + L V+F S + GF A Y+ + G
Sbjct: 381 EVRDGFWRKAPLR-GRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV 439
Query: 279 KEGQG 283
K+ G
Sbjct: 440 KKDYG 444
>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
Length = 449
Score = 154 bits (390), Expect = 1e-37
Identities = 96/260 (36%), Positives = 129/260 (49%), Gaps = 18/260 (6%)
Query: 13 LLTACALL-PFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPE 71
LL A ALL P Q Q + CGG + SG +S FP LYP N EC W I V E
Sbjct: 9 LLLAVALLGPGLQAQAMEGVK----CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAE 64
Query: 72 GQTVSLSFRVFDLELHPACRYDALEVFAG-SGTSGQRLGRFCGTFRPAPLVAPGNQVTLR 130
G +V L+F FDLE H C +D LE++ G S G LGRFCG P P + + +++
Sbjct: 65 GSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVI 124
Query: 131 MTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHI 190
+D+ GF ++G + CGG L G LT+P +P ++YP + C W I
Sbjct: 125 FHSDKHVASHGF--------SAGYQKDVCGGVLTGLSGVLTSPEYP-NNYPNSMECHWVI 175
Query: 191 IAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNE 250
A + L F F +E + C YD V+V G R +CG P ++ S G+E
Sbjct: 176 RAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHE 232
Query: 251 LLVQFVSDLSVTADGFSASY 270
L V F SD ++ GF A Y
Sbjct: 233 LQVVFKSDFNIGGRGFKAYY 252
Score = 135 bits (339), Expect = 1e-31
Identities = 94/286 (32%), Positives = 139/286 (48%), Gaps = 21/286 (7%)
Query: 23 AQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVF 82
+ G + Y + V CGG + G SG + S +PN YP + EC W I V L F F
Sbjct: 133 SHGFSAGYQKDV--CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDF 190
Query: 83 DLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF 142
+E + C YD + V G G + R +CG+ RP LV+ G+++ + +D GGRGF
Sbjct: 191 QVEGNEECTYDYVAVLGGPGPT--RGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGF 248
Query: 143 LLWY-SGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALT 201
+Y SG C +G ++P +P S YP I C W I PP + +
Sbjct: 249 KAYYFSGE---------CQEVYMAMRGNFSSPQYPSS-YPNNIRCHWTIRLPPGYQVKVF 298
Query: 202 FEKFDLE-PDTY---CRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVS 257
F DLE P++ C +D ++ F+GA S+++ LG +CG +P ++S N+LL+ +
Sbjct: 299 FLDLDLEEPNSLTKTCDFDHLAAFDGA-SEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHT 357
Query: 258 DLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKSQPP 303
D S T GFS +Y G G G +P+ P S PP
Sbjct: 358 DRSTTRRGFSVAYIGGQLGCG-SGSTEGEGEALQPQSLQSPSSIPP 402
Score = 87.4 bits (215), Expect = 2e-17
Identities = 44/113 (38%), Positives = 59/113 (52%), Gaps = 1/113 (0%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG L G ++PN+P YP CSW I+ + LTF FDLE C +D +
Sbjct: 30 CGGVLSAPSGNFSSPNFPRL-YPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
++NGA D LG+FCG P +S + + V F SD V + GFSA Y+
Sbjct: 89 EIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
Length = 609
Score = 151 bits (382), Expect = 1e-36
Identities = 88/253 (34%), Positives = 135/253 (53%), Gaps = 16/253 (6%)
Query: 37 CGGDVKGES-GYVASEGFPNLYPPNKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYD 93
CG +K ES GY+ S G+P+ Y P+++C W I P+ Q + ++F FDLE C+YD
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
Query: 94 ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSG 153
+EVF G +G G+FCG P P+V+ G + ++ +D T G GF + Y G
Sbjct: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE-IFKRG 144
Query: 154 TEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT-- 211
E C G + +P +PE YP + C++ + AP I L FE FDLEPD+
Sbjct: 145 PE---CSQNYTTPSGVIKSPGFPEK-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
Query: 212 ----YCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFS 267
+CRYD + +++G D +G++CG PG I S L + F +D ++ +GFS
Sbjct: 201 PGGMFCRYDRLEIWDG-FPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFS 259
Query: 268 ASYKTLPRGTAKE 280
A+Y L +++
Sbjct: 260 ANYSVLQSSVSED 272
Score = 70.5 bits (171), Expect = 3e-12
Identities = 49/172 (28%), Positives = 74/172 (43%), Gaps = 25/172 (14%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLE--LHPA----C 90
C + SG + S GFP YP + EC + + P+ + L F FDLE +P C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
Query: 91 RYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA 150
RYD LE++ G G +GR+CG P + + +++ TD GF YS
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
Query: 151 TSGTEHQFC-------GGRLEKAQGTLTTP------------NWPESDYPPG 183
+S +E C G + Q T ++ N+PE+ + PG
Sbjct: 267 SSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPG 318
>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
Length = 644
Score = 151 bits (382), Expect = 1e-36
Identities = 88/253 (34%), Positives = 135/253 (53%), Gaps = 16/253 (6%)
Query: 37 CGGDVKGES-GYVASEGFPNLYPPNKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYD 93
CG +K ES GY+ S G+P+ Y P+++C W I P+ Q + ++F FDLE C+YD
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
Query: 94 ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSG 153
+EVF G +G G+FCG P P+V+ G + ++ +D T G GF + Y G
Sbjct: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE-IFKRG 144
Query: 154 TEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT-- 211
E C G + +P +PE YP + C++ + AP I L FE FDLEPD+
Sbjct: 145 PE---CSQNYTTPSGVIKSPGFPEK-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
Query: 212 ----YCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFS 267
+CRYD + +++G D +G++CG PG I S L + F +D ++ +GFS
Sbjct: 201 PGGMFCRYDRLEIWDG-FPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFS 259
Query: 268 ASYKTLPRGTAKE 280
A+Y L +++
Sbjct: 260 ANYSVLQSSVSED 272
Score = 70.5 bits (171), Expect = 3e-12
Identities = 49/172 (28%), Positives = 74/172 (43%), Gaps = 25/172 (14%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLE--LHPA----C 90
C + SG + S GFP YP + EC + + P+ + L F FDLE +P C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
Query: 91 RYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA 150
RYD LE++ G G +GR+CG P + + +++ TD GF YS
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
Query: 151 TSGTEHQFC-------GGRLEKAQGTLTTP------------NWPESDYPPG 183
+S +E C G + Q T ++ N+PE+ + PG
Sbjct: 267 SSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPG 318
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 151 bits (382), Expect = 1e-36
Identities = 88/253 (34%), Positives = 135/253 (53%), Gaps = 16/253 (6%)
Query: 37 CGGDVKGES-GYVASEGFPNLYPPNKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYD 93
CG +K ES GY+ S G+P+ Y P+++C W I P+ Q + ++F FDLE C+YD
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
Query: 94 ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSG 153
+EVF G +G G+FCG P P+V+ G + ++ +D T G GF + Y G
Sbjct: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE-IFKRG 144
Query: 154 TEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT-- 211
E C G + +P +PE YP + C++ + AP I L FE FDLEPD+
Sbjct: 145 PE---CSQNYTTPSGVIKSPGFPEK-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
Query: 212 ----YCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFS 267
+CRYD + +++G D +G++CG PG I S L + F +D ++ +GFS
Sbjct: 201 PGGMFCRYDRLEIWDG-FPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFS 259
Query: 268 ASYKTLPRGTAKE 280
A+Y L +++
Sbjct: 260 ANYSVLQSSVSED 272
Score = 70.5 bits (171), Expect = 3e-12
Identities = 49/172 (28%), Positives = 74/172 (43%), Gaps = 25/172 (14%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLE--LHPA----C 90
C + SG + S GFP YP + EC + + P+ + L F FDLE +P C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
Query: 91 RYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA 150
RYD LE++ G G +GR+CG P + + +++ TD GF YS
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
Query: 151 TSGTEHQFC-------GGRLEKAQGTLTTP------------NWPESDYPPG 183
+S +E C G + Q T ++ N+PE+ + PG
Sbjct: 267 SSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPG 318
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 148 bits (374), Expect = 9e-36
Identities = 80/242 (33%), Positives = 130/242 (53%), Gaps = 11/242 (4%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CG ++ GE G + S FPN+YP + C WTI P+ Q + L+F VF++ C D +E
Sbjct: 817 CGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVE 875
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
+ + S ++CGT P+ + + N + + T GF+ +S E
Sbjct: 876 IGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFS------AED 929
Query: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
CG L ++ GT+ +P P + YP GI+C+WHI+ P+ +I L FE F LE C D
Sbjct: 930 LACGEILTESTGTIQSPGHP-NVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTND 988
Query: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276
+ V++ +D LG++CG ++P S++S GN L++ FV+D + +GF +Y+ +
Sbjct: 989 YLEVYD---TDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAA 1045
Query: 277 TA 278
TA
Sbjct: 1046 TA 1047
Score = 147 bits (370), Expect = 2e-35
Identities = 87/242 (35%), Positives = 132/242 (54%), Gaps = 9/242 (3%)
Query: 34 VFLCGGDVKGESGYVASEGFPNL-YPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRY 92
+ CGG SG + S + YP + C++TITV + + + L F FD+ +C +
Sbjct: 3034 IISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSH 3093
Query: 93 DALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATS 152
D L ++ G+ TS LG+FCG+ RP + + N + L TD +G+ + S R T
Sbjct: 3094 DYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKM--SFRQTL 3151
Query: 153 GTEHQFCGGRLEKAQGTLTTPNWPESD-YPPGISCSWHIIAPPDQVIALTFEKFDLEPDT 211
G + Q CGG L + T +P+ + Y ++C W IIAP ++VI LTF F LE +
Sbjct: 3152 GPQ-QGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAS 3210
Query: 212 ---YCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSA 268
C YD V +++G S+++ G FCG VP S GN L VQF+SDL++ +GF+A
Sbjct: 3211 TRQRCLYDYVKLYDGD-SENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNA 3269
Query: 269 SY 270
+Y
Sbjct: 3270 TY 3271
Score = 146 bits (369), Expect = 3e-35
Identities = 85/242 (35%), Positives = 123/242 (50%), Gaps = 16/242 (6%)
Query: 34 VFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYD 93
V+ CGG++ G +G +S GFPN YPPNKECIW I G ++ L+ FD+E H C +D
Sbjct: 1388 VYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFD 1447
Query: 94 ALEVFAGSGTSGQRLGRFC---GTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA 150
LE++ G R+ + C P + + GN++ +R TD GRGF S +A
Sbjct: 1448 VLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNA--SWQA 1505
Query: 151 TSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPD 210
+G CGG + G + +PN+P S Y CSW I + + L F FDLEP
Sbjct: 1506 VTGG----CGGIFQAPSGEIHSPNYP-SPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQ 1560
Query: 211 TYCRYDSVSVFNGAVSDDSRRLGKFCG-DAVPGSISSEGNELLVQFVSDLSVTADGFSAS 269
C + ++G +S RL + CG + + I S GN L ++F S S GF A
Sbjct: 1561 DSC----IMAYDG-LSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQ 1615
Query: 270 YK 271
++
Sbjct: 1616 FR 1617
Score = 136 bits (343), Expect = 3e-32
Identities = 82/246 (33%), Positives = 123/246 (50%), Gaps = 24/246 (9%)
Query: 46 GYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSG 105
G + S G+PN Y N+ C WTI G TV+ +F FDLE H C D LE++ G
Sbjct: 1289 GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP---- 1344
Query: 106 QRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQF----CGG 161
+++GR+CG P P +++ + + TD GR G + Q+ CGG
Sbjct: 1345 RQMGRYCGVDLPPPGSTTSSKLQVLLLTDG-----------VGRREKGFQMQWFVYGCGG 1393
Query: 162 RLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF 221
L A G+ ++P +P YPP C W+I P I LT FD+E + C +D + ++
Sbjct: 1394 ELSGATGSFSSPGFPNR-YPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIY 1452
Query: 222 NGAVSDDSRRLGKFCGDAVPGS---ISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278
G S R+ + C P + +SS GNEL ++F +DLS+ GF+AS++ + G
Sbjct: 1453 GGP-DFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCG 1511
Query: 279 KEGQGP 284
Q P
Sbjct: 1512 GIFQAP 1517
Score = 135 bits (339), Expect = 1e-31
Identities = 79/254 (31%), Positives = 122/254 (48%), Gaps = 15/254 (5%)
Query: 24 QGQTPNYTRPVFLCGGDV----KGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSF 79
QG Y CGG+V +GYV S P+ YPP+ +CIW + P + L F
Sbjct: 2204 QGFKIKYEAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQF 2263
Query: 80 RV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTG 138
FD+E+ P C + LE+ G + L +FCGT P+ + G + LR +D
Sbjct: 2264 EDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPT 2323
Query: 139 GRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVI 198
GF YS CGGR+ G + + P Y + C WH+ +
Sbjct: 2324 HVGFKAKYSIAQ--------CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYL 2375
Query: 199 ALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSD 258
++FE F+L+ + C D V +++ S + LG++CG+ +P SI + N +V+FV+D
Sbjct: 2376 TISFEDFNLQNSSGCEKDFVEIWDNHTSGNI--LGRYCGNTIPDSIDTSSNTAVVRFVTD 2433
Query: 259 LSVTADGFSASYKT 272
SVTA GF +++
Sbjct: 2434 GSVTASGFRLRFES 2447
Score = 133 bits (335), Expect = 3e-31
Identities = 93/259 (35%), Positives = 130/259 (50%), Gaps = 18/259 (6%)
Query: 25 GQTPNYTRPV-FLCGGDVKGE-SGYVASEGFPNL--YPPNKECIWTITVPE--GQTVSLS 78
G T +YT +CGG + G S G+ + Y N C WT++ P ++S+
Sbjct: 2557 GFTASYTSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIH 2616
Query: 79 FRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPA-PLVAPGNQVTLRMTTDEGT 137
F F LE H C++D LE G G + R CG +P PLV P +QV + T+E
Sbjct: 2617 FEDFYLESHQDCQFDVLEFRVGDA-DGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERV 2675
Query: 138 GGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQV 197
GF YS CGG G +T+PN+P + Y CS + AP
Sbjct: 2676 EHIGFHAKYS--------FTDCGGIQIGDSGVITSPNYPNA-YDSLTHCSSLLEAPQGHT 2726
Query: 198 IALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVS 257
I LTF FD+EP T C +DSV+V NG S +S +G++CG++ P +I S N+L+V F S
Sbjct: 2727 ITLTFSDFDIEPHTTCAWDSVTVRNGG-SPESPIIGQYCGNSNPRTIQSGSNQLVVTFNS 2785
Query: 258 DLSVTADGFSASYKTLPRG 276
D S+ GF A++ T G
Sbjct: 2786 DHSLQGGGFYATWNTQTLG 2804
Score = 130 bits (326), Expect = 3e-30
Identities = 73/236 (30%), Positives = 111/236 (47%), Gaps = 10/236 (4%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG G+SG + S +PN Y C + P+G T++L+F FD+E H C +D++
Sbjct: 2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVT 2748
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
V G +G++CG P + + NQ+ + +D G GF AT T+
Sbjct: 2749 VRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFY------ATWNTQT 2802
Query: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEP--DTYCR 214
CGG GT+ +P+WP+ ++P CSW I + + ++F+ L P D C+
Sbjct: 2803 LGCGGIFHSDNGTIRSPHWPQ-NFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQ 2861
Query: 215 YDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
V V+ G D L CG+ PG + + N F S A GFSAS+
Sbjct: 2862 NSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASF 2916
Score = 129 bits (325), Expect = 4e-30
Identities = 78/237 (32%), Positives = 116/237 (48%), Gaps = 12/237 (5%)
Query: 37 CGGDVKGES-GYVASEGFPNLYPPNKECIWTITV-PEGQTVSLSFRVFDLELHPACRYDA 94
CGG + S V+S FP YP N+ C W I P ++LSF F+LE C D
Sbjct: 1620 CGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDF 1679
Query: 95 LEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGT 154
+E+ G GR+CGT P P+ + + +TLR +D GF T
Sbjct: 1680 VEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGF------HTTVTA 1733
Query: 155 EHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCR 214
CGG A+G +P +P+ YPP + C W+I++ P + L+F F LE C
Sbjct: 1734 SVSACGGTFYMAEGIFNSPGYPDI-YPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCS 1792
Query: 215 YDSVSVFNGAVSDDSRRLGKFCGDAVPGSISS-EGNELLVQFVSDLSVTADGFSASY 270
D V + G + +G++CG++ P + SS G+ L V+F+SD S + GF A++
Sbjct: 1793 RDFVEIREGNAT--GHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATF 1847
Score = 125 bits (315), Expect = 6e-29
Identities = 78/238 (32%), Positives = 116/238 (48%), Gaps = 11/238 (4%)
Query: 40 DVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFA 99
++ G G VAS +P YP N WT+ V V D+E C YD L ++
Sbjct: 1855 NIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYD 1914
Query: 100 GSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLL-WYSGRATSGTEHQF 158
G + +G +CGT + + GN +T +D G+GFLL W++ A G
Sbjct: 1915 GPSIHARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTI 1973
Query: 159 ----CGG--RLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTY 212
CGG R A L +P WP+S Y + C+W +I PD + L D+E
Sbjct: 1974 APGACGGFLRTGDAPVFLFSPGWPDS-YSNRVDCTW-LIQAPDSTVELNILSLDIESHRT 2031
Query: 213 CRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
C YDS+ + +G ++ +++L CG +PG I S G + ++F SD SVT GF+AS+
Sbjct: 2032 CAYDSLVIRDGD-NNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASF 2088
Score = 124 bits (311), Expect = 2e-28
Identities = 82/253 (32%), Positives = 119/253 (47%), Gaps = 17/253 (6%)
Query: 23 AQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVF 82
AQG + ++ V CG + G SGY+ S +P Y N C + I V L+F F
Sbjct: 2909 AQGFSASF---VSRCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSF 2965
Query: 83 DLELHPA----CRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTG 138
LE A C D + + G CG PAPL G V L ++E
Sbjct: 2966 HLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAG-PVLLNFYSNEQIT 3024
Query: 139 GRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVI 198
GF +S R S CGG + G +T+P + +DYP + C + I D+VI
Sbjct: 3025 DFGFK--FSYRIIS------CGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVI 3076
Query: 199 ALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSD 258
L F FD+ P T C +D +++++GA + D LGKFCG P ++ S N +L+ F +D
Sbjct: 3077 ELKFSDFDVVPSTSCSHDYLAIYDGANTSDP-LLGKFCGSKRPPNVKSSNNSMLLVFKTD 3135
Query: 259 LSVTADGFSASYK 271
TA G+ S++
Sbjct: 3136 SFQTAKGWKMSFR 3148
Score = 122 bits (305), Expect = 9e-28
Identities = 78/276 (28%), Positives = 125/276 (45%), Gaps = 12/276 (4%)
Query: 33 PVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRY 92
P +CG + G +G + Y + C W I G+ + ++F F LE C +
Sbjct: 470 PQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPH 529
Query: 93 DALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATS 152
+ L+V+ G +S +LGRFCG+ P L++ N + + ++ GRGF + +
Sbjct: 530 EFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWE----- 584
Query: 153 GTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTY 212
T+ CGG L G++ +P +P +YPPG C W ++ PD ++ TF LE
Sbjct: 585 -TQQPECGGILTGPYGSIKSPGYP-GNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDD 642
Query: 213 CRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKT 272
C D + + +G + D LGKFC + + G + F SD ++ GF +Y T
Sbjct: 643 CNKDYLEIRDGPLYQDP-LLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLT 701
Query: 273 LPRGTAKEGQGPGPKRGTEPKVKLPPKSQPPEKTEE 308
P G P E ++ LP S P T +
Sbjct: 702 SPSDLRCGGNYTDP----EGELFLPELSGPFTHTRQ 733
Score = 121 bits (304), Expect = 1e-27
Identities = 74/245 (30%), Positives = 115/245 (46%), Gaps = 21/245 (8%)
Query: 37 CGGDVKGESG--YVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDA 94
CGG ++ ++ S G+P+ Y +C W I P+ TV L+ D+E H C YD+
Sbjct: 1978 CGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDS-TVELNILSLDIESHRTCAYDS 2036
Query: 95 LEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGT 154
L + G Q+L CG P P+ + G + +R T+D GF + +
Sbjct: 2037 LVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGF---------NAS 2087
Query: 155 EHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEK-FDL-EPDTY 212
H+ CGG L +G +T+P +PE+ YP ++CSWH++ IA+ FE+ F + D+
Sbjct: 2088 FHKSCGGYLHADRGIITSPKYPET-YPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSS 2146
Query: 213 CRYDSVSVFNGAVSDDSRRL------GKFCGDAVPGSISSEGNELLVQFVSDLSVTADGF 266
C V S L G FCG ++ + N++ VQF+SD S GF
Sbjct: 2147 CNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGF 2206
Query: 267 SASYK 271
Y+
Sbjct: 2207 KIKYE 2211
Score = 120 bits (301), Expect = 3e-27
Identities = 70/244 (28%), Positives = 124/244 (50%), Gaps = 11/244 (4%)
Query: 29 NYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHP 88
++T + C D G + S G+P+ Y +K+C T+T P+ T+SL F +E
Sbjct: 3387 SFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSV 3446
Query: 89 ACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF-LLWYS 147
CR D LEV GS ++ LG++CGT P P+ + N++ LR +D T RG+ ++W S
Sbjct: 3447 ECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTS 3506
Query: 148 GRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDL 207
+ SG CGG L +G+ T+P +P YP C W ++AP +++ + F +
Sbjct: 3507 --SPSG-----CGGTLYGDRGSFTSPGYP-GTYPNNTYCEWVLVAPAGRLVTINFYFISI 3558
Query: 208 EPDTYCRYDSVSVFNGAVSDDSRRLGKFC-GDAVPGSISSEGNELLVQFVSDLSVTADGF 266
+ C + +++++G + S G +C GD + N++ ++F +D + F
Sbjct: 3559 DDPGDCVQNYLTLYDGP-NASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAF 3617
Query: 267 SASY 270
++
Sbjct: 3618 RLTW 3621
Score = 117 bits (292), Expect = 3e-26
Identities = 81/260 (31%), Positives = 123/260 (47%), Gaps = 22/260 (8%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSF-RVFDLEL-HPACRY-D 93
CGG + + G + S +P YP N C W + V G T+++ F + F + +C D
Sbjct: 2092 CGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGD 2151
Query: 94 ALEVFAGSGTSGQRLG------RFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS 147
L + G LG FCG+ + L NQ+ ++ +D G+GF + Y
Sbjct: 2152 YLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYE 2211
Query: 148 GRATSGTEHQFCGGRL----EKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFE 203
++ + CGG + + G +T+PN P + YPP C W + APP+ I L FE
Sbjct: 2212 AKSLA------CGGNVYIHDADSAGYVTSPNHPHN-YPPHADCIWILAAPPETRIQLQFE 2264
Query: 204 -KFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVT 262
+FD+E C + + + +G V D+ L KFCG ++P S S G + ++F SD S T
Sbjct: 2265 DRFDIEVTPNCTSNYLELRDG-VDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPT 2323
Query: 263 ADGFSASYKTLPRGTAKEGQ 282
GF A Y G GQ
Sbjct: 2324 HVGFKAKYSIAQCGGRVPGQ 2343
Score = 116 bits (291), Expect = 4e-26
Identities = 75/236 (31%), Positives = 111/236 (47%), Gaps = 9/236 (3%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRY-DAL 95
C D + G S FPN YP N ECI+ ITV GQ +++ F F LE Y D L
Sbjct: 1048 CLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFL 1107
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTE 155
E+ G LG F G+ P +++ N++ L+ +D+ GF ++ G +T
Sbjct: 1108 EIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTG--- 1164
Query: 156 HQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRY 215
CGG L + GT +PN+P Y C W + + L F+ F LE C
Sbjct: 1165 ---CGGNLTTSSGTFISPNYP-MPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTL 1220
Query: 216 DSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
D ++V++G S +S L + CGD P I S G+ + ++ +D GF A Y+
Sbjct: 1221 DYLAVYDGP-SSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYR 1275
Score = 114 bits (286), Expect = 1e-25
Identities = 76/245 (31%), Positives = 110/245 (44%), Gaps = 13/245 (5%)
Query: 23 AQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVF 82
A G T V CGG G S G+P++YPPN EC+W I G + LSF F
Sbjct: 1724 AGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISF 1783
Query: 83 DLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVA-PGNQVTLRMTTDEGTGGRG 141
LE C D +E+ G+ T G +GR+CG P + G+ + +R +D G G
Sbjct: 1784 QLEDSQDCSRDFVEIREGNAT-GHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTG 1842
Query: 142 FLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALT 201
F + F + G + +P WPE +YP + W + V+
Sbjct: 1843 FQATFM--------KIFGNDNIVGTHGKVASPFWPE-NYPHNSNYQWTVNVNASHVVHGR 1893
Query: 202 FEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSV 261
+ D+E C YD + +++G S +R +G +CG S SS GN L F SD S+
Sbjct: 1894 ILEMDIEEIQNCYYDKLRIYDGP-SIHARLIGAYCGTQTE-SFSSTGNSLTFHFYSDSSI 1951
Query: 262 TADGF 266
+ GF
Sbjct: 1952 SGKGF 1956
Score = 107 bits (266), Expect = 3e-23
Identities = 66/224 (29%), Positives = 105/224 (46%), Gaps = 17/224 (7%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG++ SG S +P Y + EC W + G L F+ F LE HP C D L
Sbjct: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
V+ G ++ L + CG +P + + G+ + +++ TDEG GRGF Y
Sbjct: 1225 VYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY---------R 1275
Query: 157 QFCGG--RLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCR 214
Q C + + G L + +P + Y C+W I A + TF FDLE C
Sbjct: 1276 QTCENVVIVNQTYGILESIGYP-NPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCS 1334
Query: 215 YDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSD 258
D + +++G R++G++CG +P S+ ++L V ++D
Sbjct: 1335 TDYLELYDG-----PRQMGRYCGVDLPPPGSTTSSKLQVLLLTD 1373
Score = 102 bits (253), Expect = 9e-22
Identities = 69/235 (29%), Positives = 102/235 (43%), Gaps = 10/235 (4%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG + G G + S G+P YPP ++C+W + V+ +F LE H C D LE
Sbjct: 590 CGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLE 649
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
+ G LG+FC TF PL G + +D +GF + Y TS ++
Sbjct: 650 IRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITY---LTSPSDL 706
Query: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
+ CGG +G L P + C + + P + I + F +L+ C+ D
Sbjct: 707 R-CGGNYTDPEGELFLPEL-SGPFTHTRQCVYMMKQPQGEQIQINFTHVELQ----CQSD 760
Query: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
S + V D LGK CG+ I S N + ++F D SV F A Y+
Sbjct: 761 SSQNYI-EVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQ 814
Score = 97.8 bits (242), Expect = 2e-20
Identities = 69/241 (28%), Positives = 113/241 (46%), Gaps = 15/241 (6%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGGD++G G S +PN P + C W IT PEG+ ++L F L HP+C + +
Sbjct: 2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVI 2511
Query: 97 VFAGSGTSGQRLGRFCGTFRPA-PLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTE 155
VF G ++ +L + C + + + + GN + + TD GF Y + +E
Sbjct: 2512 VFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY-----TSSE 2566
Query: 156 HQFCGGRLEKA-QGTLTTPNWP-ESDYPPGISCSWHIIAP--PDQVIALTFEKFDLEPDT 211
CGG L +G T+P + +Y ++C W + P + I++ FE F LE
Sbjct: 2567 DAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQ 2626
Query: 212 YCRYDSVSVFNGAVSD-DSRRLGKFCGDAVPG-SISSEGNELLVQFVSDLSVTADGFSAS 269
C++D V V D D + + CG + P + +++ + FV++ V GF A
Sbjct: 2627 DCQFD---VLEFRVGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAK 2683
Query: 270 Y 270
Y
Sbjct: 2684 Y 2684
Score = 88.2 bits (217), Expect = 1e-17
Identities = 69/249 (27%), Positives = 111/249 (44%), Gaps = 24/249 (9%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPA----CRY 92
CGG ++G + S +P +P N C WT + + + +SF + L P+ C+
Sbjct: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFD--NNFLIPSGDGQCQN 2862
Query: 93 DALEVFAGSGTSGQRL-GRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRAT 151
++V+AG+ + L CG P P++ P N T + E +GF + R
Sbjct: 2863 SFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPA-QGFSASFVSR-- 2919
Query: 152 SGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT 211
CG G + +PN+P+ Y ++C++ I A P V+ LTF F LE +
Sbjct: 2920 -------CGSNFTGPSGYIISPNYPKQ-YDNNMNCTYVIEANPLSVVLLTFVSFHLEARS 2971
Query: 212 Y----CRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFS 267
C D V + G S S CGD +P ++ G +L+ F S+ +T GF
Sbjct: 2972 AVTGSCVNDGVHIIRG-YSVMSTPFATVCGDEMPAPLTIAG-PVLLNFYSNEQITDFGFK 3029
Query: 268 ASYKTLPRG 276
SY+ + G
Sbjct: 3030 FSYRIISCG 3038
Score = 83.6 bits (205), Expect = 3e-16
Identities = 73/262 (27%), Positives = 109/262 (41%), Gaps = 25/262 (9%)
Query: 24 QGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKE--------CIWTITVPEGQTV 75
+G YT CGG Y A+ N+ PN C W I P Q V
Sbjct: 3265 EGFNATYTIMDMPCGGT------YNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQV 3318
Query: 76 SLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDE 135
++ L C + L++ G +FCG A V + T +
Sbjct: 3319 KITVWALQLTSQD-CTQNYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKS 3377
Query: 136 GTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPD 195
G R + ++ + C KA G L +P WP++ Y C+ + AP +
Sbjct: 3378 GVVNRNSRMSFTYQIAD------CNRDYHKAFGNLRSPGWPDN-YDNDKDCTVTLTAPQN 3430
Query: 196 QVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQF 255
I+L F +E CR D + V NG+ S+ S LGK+CG +P + S+ NEL ++F
Sbjct: 3431 HTISLFFHSLGIENSVECRNDFLEVRNGSNSN-SPLLGKYCGTLLPNPVFSQNNELYLRF 3489
Query: 256 VSDLSVTAD-GFSASYKTLPRG 276
SD SVT+D G+ + + P G
Sbjct: 3490 KSD-SVTSDRGYEIIWTSSPSG 3510
Score = 83.2 bits (204), Expect = 4e-16
Identities = 62/227 (27%), Positives = 99/227 (43%), Gaps = 19/227 (8%)
Query: 37 CGGDVKGESGYVASEGFPN--LYPPNKECIWTITVPEGQTVSLSFRVFDLEL---HPACR 91
CGG + G + AS + +Y N C+W I P + + L+F F LE C
Sbjct: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCL 3216
Query: 92 YDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRAT 151
YD ++++ G + G FCG+ PAP ++ GN +T++ +D GF AT
Sbjct: 3217 YDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGF------NAT 3270
Query: 152 SGTEHQFCGGRLEK--AQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEP 209
CGG +++PN + D P I C+W I +PP Q + +T L
Sbjct: 3271 YTIMDMPCGGTYNATWTPQNISSPNSSDPDVPFSI-CTWVIDSPPHQQVKITVWALQLTS 3329
Query: 210 DTYCRYDSVSVFNGAVSDDSRRLGKFCG---DAVPGSISSEGNELLV 253
C + + + + + R +FCG AVP SS +++
Sbjct: 3330 QD-CTQNYLQLQDSPQGHGNSRF-QFCGRNASAVPVFYSSMSTAMVI 3374
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 140 bits (354), Expect = 2e-33
Identities = 86/268 (32%), Positives = 133/268 (49%), Gaps = 17/268 (6%)
Query: 12 PLLTACALLPFAQGQTPNYTRPVFLCGGDVKG-ESGYVASEGFPNLYPPNKECIWTITVP 70
PL L F++ Q P CGG + ++GY+ S G+P YP ++ C W + P
Sbjct: 5 PLTWVFLALYFSRHQVRGQPDPP--CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAP 62
Query: 71 E-GQTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVT 128
E Q + L+F F++E H C+YD +E+ G S LG+ CG P +++ G+ +
Sbjct: 63 EPNQKIVLNFNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLY 121
Query: 129 LRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSW 188
++ T+D G GF L Y T + C GT+ +P +PE YP + C++
Sbjct: 122 IKFTSDYARQGAGFSLRYEIFKTGSED---CSKNFTSPNGTIESPGFPEK-YPHNLDCTF 177
Query: 189 HIIAPPDQVIALTFEKFDLEPDTY------CRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242
I+A P I L F FDLE D C+YD + +++G + +GK+CG P
Sbjct: 178 TILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDG-IPHVGPLIGKYCGTKTPS 236
Query: 243 SISSEGNELLVQFVSDLSVTADGFSASY 270
+ S L + F +D++V DGFSA Y
Sbjct: 237 ELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 82.0 bits (201), Expect = 1e-15
Identities = 54/159 (33%), Positives = 80/159 (50%), Gaps = 6/159 (3%)
Query: 144 LWYSGRATSGTEHQFCGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALT 201
L++S G CGGRL K G +T+P +P+ DYP +C W + AP P+Q I L
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 202 FEK-FDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLS 260
F F++E C+YD + + +G S+ + LGK CG+ P +I S G+ L ++F SD +
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGD-SESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYA 129
Query: 261 VTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPK 299
GFS Y+ G+ + GT P K
Sbjct: 130 RQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEK 168
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 140 bits (354), Expect = 2e-33
Identities = 86/268 (32%), Positives = 133/268 (49%), Gaps = 17/268 (6%)
Query: 12 PLLTACALLPFAQGQTPNYTRPVFLCGGDVKG-ESGYVASEGFPNLYPPNKECIWTITVP 70
PL L F++ Q P CGG + ++GY+ S G+P YP ++ C W + P
Sbjct: 5 PLTWVFLALYFSRHQVRGQPDPP--CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAP 62
Query: 71 E-GQTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVT 128
E Q + L+F F++E H C+YD +E+ G S LG+ CG P +++ G+ +
Sbjct: 63 EPNQKIVLNFNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLY 121
Query: 129 LRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSW 188
++ T+D G GF L Y T + C GT+ +P +PE YP + C++
Sbjct: 122 IKFTSDYARQGAGFSLRYEIFKTGSED---CSKNFTSPNGTIESPGFPEK-YPHNLDCTF 177
Query: 189 HIIAPPDQVIALTFEKFDLEPDTY------CRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242
I+A P I L F FDLE D C+YD + +++G + +GK+CG P
Sbjct: 178 TILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDG-IPHVGPLIGKYCGTKTPS 236
Query: 243 SISSEGNELLVQFVSDLSVTADGFSASY 270
+ S L + F +D++V DGFSA Y
Sbjct: 237 ELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 82.0 bits (201), Expect = 1e-15
Identities = 54/159 (33%), Positives = 80/159 (50%), Gaps = 6/159 (3%)
Query: 144 LWYSGRATSGTEHQFCGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALT 201
L++S G CGGRL K G +T+P +P+ DYP +C W + AP P+Q I L
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 202 FEK-FDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLS 260
F F++E C+YD + + +G S+ + LGK CG+ P +I S G+ L ++F SD +
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGD-SESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYA 129
Query: 261 VTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPK 299
GFS Y+ G+ + GT P K
Sbjct: 130 RQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEK 168
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 140 bits (354), Expect = 2e-33
Identities = 86/268 (32%), Positives = 133/268 (49%), Gaps = 17/268 (6%)
Query: 12 PLLTACALLPFAQGQTPNYTRPVFLCGGDVKG-ESGYVASEGFPNLYPPNKECIWTITVP 70
PL L F++ Q P CGG + ++GY+ S G+P YP ++ C W + P
Sbjct: 5 PLTWVFLALYFSRHQVRGQPDPP--CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAP 62
Query: 71 E-GQTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVT 128
E Q + L+F F++E H C+YD +E+ G S LG+ CG P +++ G+ +
Sbjct: 63 EPNQKIVLNFNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLY 121
Query: 129 LRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSW 188
++ T+D G GF L Y T + C GT+ +P +PE YP + C++
Sbjct: 122 IKFTSDYARQGAGFSLRYEIFKTGSED---CSKNFTSPNGTIESPGFPEK-YPHNLDCTF 177
Query: 189 HIIAPPDQVIALTFEKFDLEPDTY------CRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242
I+A P I L F FDLE D C+YD + +++G + +GK+CG P
Sbjct: 178 TILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDG-IPHVGPLIGKYCGTKTPS 236
Query: 243 SISSEGNELLVQFVSDLSVTADGFSASY 270
+ S L + F +D++V DGFSA Y
Sbjct: 237 ELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 82.0 bits (201), Expect = 1e-15
Identities = 54/159 (33%), Positives = 80/159 (50%), Gaps = 6/159 (3%)
Query: 144 LWYSGRATSGTEHQFCGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALT 201
L++S G CGGRL K G +T+P +P+ DYP +C W + AP P+Q I L
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 202 FEK-FDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLS 260
F F++E C+YD + + +G S+ + LGK CG+ P +I S G+ L ++F SD +
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGD-SESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYA 129
Query: 261 VTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPK 299
GFS Y+ G+ + GT P K
Sbjct: 130 RQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEK 168
>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
Length = 555
Score = 140 bits (354), Expect = 2e-33
Identities = 86/268 (32%), Positives = 133/268 (49%), Gaps = 17/268 (6%)
Query: 12 PLLTACALLPFAQGQTPNYTRPVFLCGGDVKG-ESGYVASEGFPNLYPPNKECIWTITVP 70
PL L F++ Q P CGG + ++GY+ S G+P YP ++ C W + P
Sbjct: 5 PLTWVFLALYFSRHQVRGQPDPP--CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAP 62
Query: 71 E-GQTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVT 128
E Q + L+F F++E H C+YD +E+ G S LG+ CG P +++ G+ +
Sbjct: 63 EPNQKIVLNFNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLY 121
Query: 129 LRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSW 188
++ T+D G GF L Y T + C GT+ +P +PE YP + C++
Sbjct: 122 IKFTSDYARQGAGFSLRYEIFKTGSED---CSKNFTSPNGTIESPGFPEK-YPHNLDCTF 177
Query: 189 HIIAPPDQVIALTFEKFDLEPDTY------CRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242
I+A P I L F FDLE D C+YD + +++G + +GK+CG P
Sbjct: 178 TILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDG-IPHVGPLIGKYCGTKTPS 236
Query: 243 SISSEGNELLVQFVSDLSVTADGFSASY 270
+ S L + F +D++V DGFSA Y
Sbjct: 237 ELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 82.0 bits (201), Expect = 1e-15
Identities = 54/159 (33%), Positives = 80/159 (50%), Gaps = 6/159 (3%)
Query: 144 LWYSGRATSGTEHQFCGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALT 201
L++S G CGGRL K G +T+P +P+ DYP +C W + AP P+Q I L
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 202 FEK-FDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLS 260
F F++E C+YD + + +G S+ + LGK CG+ P +I S G+ L ++F SD +
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGD-SESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYA 129
Query: 261 VTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPK 299
GFS Y+ G+ + GT P K
Sbjct: 130 RQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEK 168
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 140 bits (354), Expect = 2e-33
Identities = 86/268 (32%), Positives = 133/268 (49%), Gaps = 17/268 (6%)
Query: 12 PLLTACALLPFAQGQTPNYTRPVFLCGGDVKG-ESGYVASEGFPNLYPPNKECIWTITVP 70
PL L F++ Q P CGG + ++GY+ S G+P YP ++ C W + P
Sbjct: 5 PLTWVFLALYFSRHQVRGQPDPP--CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAP 62
Query: 71 E-GQTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVT 128
E Q + L+F F++E H C+YD +E+ G S LG+ CG P +++ G+ +
Sbjct: 63 EPNQKIVLNFNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLY 121
Query: 129 LRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSW 188
++ T+D G GF L Y T + C GT+ +P +PE YP + C++
Sbjct: 122 IKFTSDYARQGAGFSLRYEIFKTGSED---CSKNFTSPNGTIESPGFPEK-YPHNLDCTF 177
Query: 189 HIIAPPDQVIALTFEKFDLEPDTY------CRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242
I+A P I L F FDLE D C+YD + +++G + +GK+CG P
Sbjct: 178 TILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDG-IPHVGPLIGKYCGTKTPS 236
Query: 243 SISSEGNELLVQFVSDLSVTADGFSASY 270
+ S L + F +D++V DGFSA Y
Sbjct: 237 ELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 82.0 bits (201), Expect = 1e-15
Identities = 54/159 (33%), Positives = 80/159 (50%), Gaps = 6/159 (3%)
Query: 144 LWYSGRATSGTEHQFCGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALT 201
L++S G CGGRL K G +T+P +P+ DYP +C W + AP P+Q I L
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 202 FEK-FDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLS 260
F F++E C+YD + + +G S+ + LGK CG+ P +I S G+ L ++F SD +
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGD-SESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYA 129
Query: 261 VTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPK 299
GFS Y+ G+ + GT P K
Sbjct: 130 RQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEK 168
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 140 bits (354), Expect = 2e-33
Identities = 86/268 (32%), Positives = 133/268 (49%), Gaps = 17/268 (6%)
Query: 12 PLLTACALLPFAQGQTPNYTRPVFLCGGDVKG-ESGYVASEGFPNLYPPNKECIWTITVP 70
PL L F++ Q P CGG + ++GY+ S G+P YP ++ C W + P
Sbjct: 5 PLTWVFLALYFSRHQVRGQPDPP--CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAP 62
Query: 71 E-GQTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVT 128
E Q + L+F F++E H C+YD +E+ G S LG+ CG P +++ G+ +
Sbjct: 63 EPNQKIVLNFNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLY 121
Query: 129 LRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSW 188
++ T+D G GF L Y T + C GT+ +P +PE YP + C++
Sbjct: 122 IKFTSDYARQGAGFSLRYEIFKTGSED---CSKNFTSPNGTIESPGFPEK-YPHNLDCTF 177
Query: 189 HIIAPPDQVIALTFEKFDLEPDTY------CRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242
I+A P I L F FDLE D C+YD + +++G + +GK+CG P
Sbjct: 178 TILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDG-IPHVGPLIGKYCGTKTPS 236
Query: 243 SISSEGNELLVQFVSDLSVTADGFSASY 270
+ S L + F +D++V DGFSA Y
Sbjct: 237 ELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 82.0 bits (201), Expect = 1e-15
Identities = 54/159 (33%), Positives = 80/159 (50%), Gaps = 6/159 (3%)
Query: 144 LWYSGRATSGTEHQFCGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALT 201
L++S G CGGRL K G +T+P +P+ DYP +C W + AP P+Q I L
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 202 FEK-FDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLS 260
F F++E C+YD + + +G S+ + LGK CG+ P +I S G+ L ++F SD +
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGD-SESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYA 129
Query: 261 VTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPK 299
GFS Y+ G+ + GT P K
Sbjct: 130 RQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEK 168
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 134 bits (336), Expect = 2e-31
Identities = 108/327 (33%), Positives = 139/327 (42%), Gaps = 76/327 (23%)
Query: 25 GQTPNYTRP----VFLCGGDVKGE-SGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSF 79
G+ + RP V CGG V+GE SG V S G+P Y N CIWTI G T+ L F
Sbjct: 1255 GERRTWDRPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHF 1314
Query: 80 RVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGG 139
VFD E +D L ++ G SG L G P L + N V L+ +TD T
Sbjct: 1315 LVFDTEEV----HDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSK 1370
Query: 140 RGFLLWYS-----------------------------------GRATSGT--------EH 156
+GF + +S G A G+ E+
Sbjct: 1371 QGFAIQFSVSTATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIEN 1430
Query: 157 QF------------CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEK 204
+F CGG L G + +PN+PE YPPG C W + PD VIAL F
Sbjct: 1431 RFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPEP-YPPGKECDWKVTVSPDYVIALVFNI 1489
Query: 205 FDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTAD 264
F+LEP YD + +++G S S +G F G +PG I S N L + F SD SV+
Sbjct: 1490 FNLEPG----YDFLHIYDGRDS-LSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNA 1544
Query: 265 GFSASYKTLPR------GTAKEGQGPG 285
GF Y PR G+ K G G
Sbjct: 1545 GFVIDYTENPRESCFDPGSIKNGTRVG 1571
Score = 112 bits (280), Expect = 7e-25
Identities = 90/313 (28%), Positives = 127/313 (40%), Gaps = 67/313 (21%)
Query: 17 CALLPFAQGQTPNYTRP--VFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQT 74
C +P A Q N + P V CGG++ G + S GFP Y + C+W I VPEG
Sbjct: 1775 CLPVPGALAQW-NVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAG 1833
Query: 75 VSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTD 134
+ + F E + +D+LEVF G+ + LG F GT PA L + NQ+ L +D
Sbjct: 1834 IQIQVVSFVTEQN----WDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSD 1889
Query: 135 EGTGGRGFLLWYS-----------------------------------GRATSGTEH--- 156
GF L Y G A G H
Sbjct: 1890 ISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISC 1949
Query: 157 ----------------QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIAL 200
CGG +E+ +G + +P +P +YP + CSW I P +
Sbjct: 1950 MPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFP-GNYPSNMDCSWKIALPVGFGAHI 2008
Query: 201 TFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLS 260
F F EP+ +D + + NG + SR +G+F G +P S+ S +E V F SD S
Sbjct: 2009 QFLNFSTEPN----HDYIEIRNGPY-ETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHS 2063
Query: 261 VTADGFSASYKTL 273
GF Y+ L
Sbjct: 2064 QNRPGFKLEYQDL 2076
Score = 94.0 bits (232), Expect = 3e-19
Identities = 83/326 (25%), Positives = 127/326 (38%), Gaps = 72/326 (22%)
Query: 22 FAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRV 81
F Q P P CGGD+ G SG + S +P YPP KEC W +TV ++L F +
Sbjct: 1433 FWQPSPPTCIAP---CGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNI 1489
Query: 82 FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRG 141
F+LE P YD L ++ G + +G F G+ P + + N + L +D G
Sbjct: 1490 FNLE--PG--YDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAG 1545
Query: 142 FLLWYS-----------------------------------GRATSGTEHQFC------- 159
F++ Y+ G GT C
Sbjct: 1546 FVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGK 1605
Query: 160 --------------GGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKF 205
GG+ + G + +PN+P+ +Y G C + + P D V+ F F
Sbjct: 1606 PVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQ-NYTSGQICLYFVTVPKDYVVFGQFAFF 1664
Query: 206 DLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSIS-SEGNELLVQFVSDLSVTAD 264
+ D V V +G S SR L G S+ + N++L++F + A
Sbjct: 1665 HTALN-----DVVEVHDGH-SQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPAR 1718
Query: 265 GFSASYKTLPRGTAKE-GQGPGPKRG 289
GF Y+ +PR +A + P P+ G
Sbjct: 1719 GFHFVYQAVPRTSATQCSSVPEPRYG 1744
Score = 88.2 bits (217), Expect = 1e-17
Identities = 77/292 (26%), Positives = 116/292 (39%), Gaps = 65/292 (22%)
Query: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTIT-VPEGQTVSLSFRVFDLELHPACRYDA 94
+C ++G SG + S FP Y N C+W IT + + + L+F FDLE YD
Sbjct: 404 MCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLER----GYDT 459
Query: 95 LEVFAGSGTSGQR--LGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS----- 147
L V G Q+ L GT P +V+ +Q+ L TD GF Y
Sbjct: 460 LTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQG 519
Query: 148 ----------GRATSGTEHQ-------------------------------------FCG 160
GR H C
Sbjct: 520 SCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCF 579
Query: 161 GRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSV 220
G + +PN+PE DY + C W I+A P+ I L F D+EP ++D + +
Sbjct: 580 FNFTSPSGVVLSPNYPE-DYGNHLHCVWLILARPESRIHLAFNDIDVEP----QFDFLVI 634
Query: 221 FNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKT 272
+GA + ++ LG F G+ +P SI+S G+ ++F +D S GF+ ++ T
Sbjct: 635 KDGATA-EAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTT 685
Score = 87.0 bits (214), Expect = 3e-17
Identities = 88/320 (27%), Positives = 129/320 (40%), Gaps = 65/320 (20%)
Query: 29 NYTRPVFL--CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFD--- 83
N RPV CGG G G V S +P Y + C++ +TVP+ V F F
Sbjct: 1609 NNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTAL 1668
Query: 84 ---LELHPACRYDA--LEVFAGS--------GTSGQRLGRFCG-----------TFRPAP 119
+E+H + L +GS TS Q L +F ++ P
Sbjct: 1669 NDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVP 1728
Query: 120 LVA-------PGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH-----------QF--- 158
+ P + R+ +D G SG A G+ Q+
Sbjct: 1729 RTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVS 1788
Query: 159 -------CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT 211
CGG L + +GT+ +P +PE Y ++C W I+ P I + F E +
Sbjct: 1789 APTCVVPCGGNLTERRGTILSPGFPEP-YLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN- 1846
Query: 212 YCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
+DS+ VF+GA + LG F G VP ++S N+L + F SD+SV+A GF YK
Sbjct: 1847 ---WDSLEVFDGA-DNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYK 1902
Query: 272 TLPRGTAKEGQGP--GPKRG 289
T+ + E P G K G
Sbjct: 1903 TVGLSSCPEPAVPSNGVKTG 1922
Score = 84.7 bits (208), Expect = 2e-16
Identities = 76/306 (24%), Positives = 122/306 (39%), Gaps = 70/306 (22%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG + SG + S G+P Y C W I G + ++F F E++ YD LE
Sbjct: 752 CGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVN----YDTLE 807
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS--------- 147
V G S +G + GT P L++ N + L +TD+ GF L Y
Sbjct: 808 VRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQSDHC 867
Query: 148 ---GRATSGTEH------------------------------------------QFCGGR 162
G +G H CGG
Sbjct: 868 LDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALCGGF 927
Query: 163 LEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF- 221
++ + GT+ +P +P+ YP ++C+W I + + TF F LE +D + +
Sbjct: 928 IQGSSGTILSPGFPDF-YPNNLNCTWIIETSHGKGVFFTFHTFHLESG----HDYLLITE 982
Query: 222 NGAVSDDSRRLGKFCGDAVPGSISS--EGN-ELLVQFVSDLSVTADGFSASYKTLPRGTA 278
NG+ + R+L G +P IS+ GN V+F+SD S++ +GF+ ++
Sbjct: 983 NGSFTQPLRQL---TGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPC 1039
Query: 279 KEGQGP 284
+E + P
Sbjct: 1040 EEPEVP 1045
Score = 74.7 bits (182), Expect = 2e-13
Identities = 75/299 (25%), Positives = 112/299 (37%), Gaps = 72/299 (24%)
Query: 34 VFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYD 93
VF C + SG V S +P Y + C+W I + L+F D+++ P ++D
Sbjct: 575 VFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFN--DIDVEP--QFD 630
Query: 94 ALEVFAGSGTSGQRLGRFCG----------------------------------TFRPAP 119
L + G+ LG F G TFR
Sbjct: 631 FLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNE 690
Query: 120 LVAPGNQV-------------TLRMTTDEGTGG------------RGFLLWYSGRATSGT 154
PG V ++ DEG G G ++W S
Sbjct: 691 CPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCEA 750
Query: 155 EHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCR 214
CGG L GT+ +P WP Y +SC+W I A P I +TF++F E
Sbjct: 751 P---CGGHLTSPSGTILSPGWP-GFYKDALSCAWVIEAQPGYPIKITFDRFKTE----VN 802
Query: 215 YDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTL 273
YD++ V +G + + +G + G VP + S N L + F +D S + GF Y+T+
Sbjct: 803 YDTLEVRDGR-TYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETI 860
Score = 74.7 bits (182), Expect = 2e-13
Identities = 77/295 (26%), Positives = 118/295 (40%), Gaps = 70/295 (23%)
Query: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
LCGG ++G SG + S GFP+ YP N C W I G+ V +F F LE +D L
Sbjct: 923 LCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLE----SGHDYL 978
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAP--GN-QVTLRMTTDEGTGGRGFLLWYS----- 147
+ +G+ Q L + G+ PAP+ A GN +R +D GF + +S
Sbjct: 979 -LITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLE 1037
Query: 148 ------------------------------GRATSGTEHQFC-GGR-------------- 162
G GT C GGR
Sbjct: 1038 PCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAE 1097
Query: 163 ----LEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
+ QGTL +PN+P +Y C + I P + I L F+L D +
Sbjct: 1098 CGNSVTGTQGTLLSPNFP-VNYNNNHECIYSIQTQPGKGIQLKARAFELSEG-----DVL 1151
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPG-SISSEGNELLVQFVSDLSVTADGFSASYKT 272
V++G ++ +R LG F + G +++S + L + F++D T+ GF + +
Sbjct: 1152 KVYDGN-NNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSS 1205
Score = 72.4 bits (176), Expect = 8e-13
Identities = 44/110 (40%), Positives = 59/110 (53%), Gaps = 8/110 (7%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG ++G+SG ++S FP+ Y N +C WTI G T++L F F LE YD LE
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLE----DGYDFLE 257
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
V +GT G L F G PAP+++ N + L T+D RGF Y
Sbjct: 258 V---TGTEGSSLW-FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQY 303
Score = 71.6 bits (174), Expect = 1e-12
Identities = 77/317 (24%), Positives = 120/317 (37%), Gaps = 72/317 (22%)
Query: 32 RPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACR 91
R V CG V G G + S FP Y N ECI++I G+ + L R F+L
Sbjct: 1093 RCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELS-----E 1147
Query: 92 YDALEVFAGSGTSGQRLGRFC-GTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS--- 147
D L+V+ G+ S + LG F L + + + L TD +GF L +S
Sbjct: 1148 GDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFE 1207
Query: 148 ---------------------------------GRATSGTEHQF---------------- 158
G + G+E
Sbjct: 1208 LIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTC 1267
Query: 159 ---CGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCR 214
CGG + + G + +P +P + Y ++C W I A I L F FD E
Sbjct: 1268 VAECGGTVRGEVSGQVLSPGYP-APYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE----V 1322
Query: 215 YDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLP 274
+D + +++G V + L + G A+P + S N +++QF +D + GF+ +
Sbjct: 1323 HDVLRIWDGPV-ESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSV-- 1379
Query: 275 RGTAKEGQGPG-PKRGT 290
TA PG P+ G+
Sbjct: 1380 -STATSCNDPGIPQNGS 1395
Score = 70.5 bits (171), Expect = 3e-12
Identities = 45/148 (30%), Positives = 70/148 (47%), Gaps = 7/148 (4%)
Query: 29 NYTRPVFL--CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLEL 86
NY P+ + CGG V+ G + S GFP YP N +C W I +P G + F F E
Sbjct: 1958 NYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEP 2017
Query: 87 HPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
+ +D +E+ G + + +GRF G+ P+ L++ ++ T+ +D GF L Y
Sbjct: 2018 N----HDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEY 2073
Query: 147 SGRATSGTEHQFCGG-RLEKAQGTLTTP 173
S F G L + + T +TP
Sbjct: 2074 QDLTYSHQISSFLRGFDLSELERTNSTP 2101
Score = 70.1 bits (170), Expect = 4e-12
Identities = 92/331 (27%), Positives = 132/331 (39%), Gaps = 72/331 (21%)
Query: 9 LLGPLLTACALLPFAQGQTPNYTRPV----FLCGGDVKGESGYVASEGFPNLYPPNKECI 64
L G LT +L G N+ P+ CGG++ +G V S GFP+ Y +++C+
Sbjct: 2150 LPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSPYSSSQDCV 2209
Query: 65 WTITVPEGQTVSLSFRVFDLELH---------PACRYDALEVFAGS-------GTSGQRL 108
W ITVP G V L+ + E P L VF S +S Q L
Sbjct: 2210 WLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVL 2269
Query: 109 GRFC------GTFR-----------PAPLVAPGNQVTLRMTTDEGTGGR--------GFL 143
+F G F P P + P +V +E G GF
Sbjct: 2270 LKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTE--NEEFNIGDIVRYRCLPGFT 2327
Query: 144 LWYSGRATS--GTEHQFCGGR------------LEKAQGTLTTPNWPESDYPPGISCSWH 189
L + T GT QF G L + G + + ++P S YP +CSW
Sbjct: 2328 LVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGS-YPQFQTCSWL 2386
Query: 190 IIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGD-AVPGSISSEG 248
+ PD I+LT E F E +YD +F+G S S L G+ + P ++S
Sbjct: 2387 VRVEPDYNISLTVEYFLSEK----QYDEFEIFDGP-SGQSPLLKALSGNYSAPLIVTSSS 2441
Query: 249 NELLVQFVSDLSVTADGF----SASYKTLPR 275
N + +++ SD + GF SA Y +LPR
Sbjct: 2442 NSVYLRWSSDHAYNRKGFKIRYSAPYCSLPR 2472
Score = 68.6 bits (166), Expect = 1e-11
Identities = 42/121 (34%), Positives = 64/121 (52%), Gaps = 6/121 (4%)
Query: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
Q C +L GT+ +P +P YP +C+W I A I L F+ F LE D +D
Sbjct: 24 QNCTFQLHGPNGTVESPGFPYG-YPNYANCTWTITAEEQHRIQLVFQSFALEED----FD 78
Query: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276
+SVF+G ++ R + G +P +I S L ++ +SD +V+A GF A+Y+ LP
Sbjct: 79 VLSVFDGPPQPENLRT-RLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSH 137
Query: 277 T 277
T
Sbjct: 138 T 138
Score = 62.4 bits (150), Expect = 8e-10
Identities = 87/327 (26%), Positives = 115/327 (35%), Gaps = 81/327 (24%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
C + G +G V S GFP YP C WTIT E + L F+ F LE +D L
Sbjct: 26 CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEED----FDVLS 81
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS--------- 147
VF G R G PA +V+ ++LR+ +D +GF Y
Sbjct: 82 VFDGPPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGN 141
Query: 148 -GRATSGTE-----------HQFCG-GRLEKAQGTLT----TPNWPESDYP--------- 181
GR +G + C G + LT + N D+P
Sbjct: 142 PGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDA 201
Query: 182 --------PGISCSWH--------------IIAPPDQVIALTFEKFDLEPDTYCRYDSVS 219
GI S H I+A IAL F F LE YD +
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFLE 257
Query: 220 VFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAK 279
V + L F G ++P + S N L + F SD + GFSA Y+ + K
Sbjct: 258 V----TGTEGSSLW-FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELK 312
Query: 280 EGQGPGPKRGTEPKVKLPPKSQPPEKT 306
RG VKL P +KT
Sbjct: 313 -------SRG----VKLMPSKDNSQKT 328
Score = 62.4 bits (150), Expect = 8e-10
Identities = 42/123 (34%), Positives = 65/123 (52%), Gaps = 7/123 (5%)
Query: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIA-PPDQVIALTFEKFDLEPDTYCRY 215
+ C L G +T+PN+P Y C W I A P +VI L FE+FDLE Y
Sbjct: 403 RMCDAHLRGPSGIITSPNFP-IQYDNNAHCVWIITALNPSKVIKLAFEEFDLERG----Y 457
Query: 216 DSVSVFNGAVSDDSRR-LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLP 274
D+++V +G D + L G +VP I S +++ + F +D S ++ GF ASY+ +
Sbjct: 458 DTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIE 517
Query: 275 RGT 277
+G+
Sbjct: 518 QGS 520
Score = 51.6 bits (122), Expect = 1e-06
Identities = 39/143 (27%), Positives = 63/143 (44%), Gaps = 8/143 (5%)
Query: 8 SLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGES-GYVASEGFPNLYPPNKECIWT 66
+L+G + C L + Q + P V ++ +S G + S+ +P YP + C W
Sbjct: 2327 TLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWL 2386
Query: 67 ITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLV--APG 124
+ V +SL+ F E +YD E+F G L G + APL+ +
Sbjct: 2387 VRVEPDYNISLTVEYFLSEK----QYDEFEIFDGPSGQSPLLKALSGNY-SAPLIVTSSS 2441
Query: 125 NQVTLRMTTDEGTGGRGFLLWYS 147
N V LR ++D +GF + YS
Sbjct: 2442 NSVYLRWSSDHAYNRKGFKIRYS 2464
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 130 bits (328), Expect = 2e-30
Identities = 89/311 (28%), Positives = 127/311 (40%), Gaps = 46/311 (14%)
Query: 2 LPAA--TASLLGPLLTA--CALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLY 57
LPA T + P +T A P Q ++ P CGG + G G+ +S +P+ Y
Sbjct: 105 LPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPY 164
Query: 58 PPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP 117
PPN C+W I V + L +E +C +D LE+ S L R CG P
Sbjct: 165 PPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL---SPEPEGPLLRVCGRVPP 221
Query: 118 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATS------------------------- 152
L + + + +D G GF WY A
Sbjct: 222 PTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDG 281
Query: 153 -------------GTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIA 199
+ CGG L QGT +TP++ + YP + C+WHI P I
Sbjct: 282 FANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ-YPHQLLCTWHISVPAGHSIE 340
Query: 200 LTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDL 259
L F F LE C++D V V+ + S LG+FCG P + S +EL V F +D
Sbjct: 341 LQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDH 400
Query: 260 SVTADGFSASY 270
+++ GFSA+Y
Sbjct: 401 GISSGGFSATY 411
Score = 76.3 bits (186), Expect = 5e-14
Identities = 43/125 (34%), Positives = 63/125 (50%), Gaps = 4/125 (3%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG++ G G ++ + YP C W I+VP G ++ L F F LE C++D +E
Sbjct: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
Query: 97 VFAGSGTSG-QRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTE 155
V+ S + LGRFCG P LV+ +++ + TD G GF Y A + TE
Sbjct: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY--LAFNATE 418
Query: 156 HQFCG 160
+ CG
Sbjct: 419 NP-CG 422
Score = 73.9 bits (180), Expect = 3e-13
Identities = 48/159 (30%), Positives = 69/159 (43%), Gaps = 5/159 (3%)
Query: 118 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE 177
+PL A G T T + G S + CGG L +G ++PN+P+
Sbjct: 103 SPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPD 162
Query: 178 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCG 237
YPP C WHI D I L E +E C +D + + + L + CG
Sbjct: 163 P-YPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELS----PEPEGPLLRVCG 217
Query: 238 DAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276
P ++++ + LLV FVSD SV GF A Y+ + G
Sbjct: 218 RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 119 bits (297), Expect = 7e-27
Identities = 87/295 (29%), Positives = 124/295 (42%), Gaps = 66/295 (22%)
Query: 37 CGGDVKGE-SGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
CGG + SG + S G+P Y N C W I G+T+SL F VFD E+ +D L
Sbjct: 1278 CGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEM----AHDIL 1333
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS-------- 147
+V+ G S L + G+ P + + N +TL+ +D GF + +S
Sbjct: 1334 KVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCN 1393
Query: 148 --GRATSGTEH---------------------------------------------QFCG 160
G +GT + CG
Sbjct: 1394 DPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACG 1453
Query: 161 GRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSV 220
G L G + +PN+P+ YPPG C W + PD VIAL F+ F++EP YD + +
Sbjct: 1454 GNLTGPAGVILSPNYPQP-YPPGKECDWRVKVNPDFVIALIFKSFNMEPS----YDFLHI 1508
Query: 221 FNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPR 275
+ G S +S +G + G P I S GN L + F SD SV GF+ +K PR
Sbjct: 1509 YEGEDS-NSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPR 1562
Score = 98.6 bits (244), Expect = 1e-20
Identities = 80/291 (27%), Positives = 129/291 (44%), Gaps = 65/291 (22%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPE-GQTVSLSFRVFDLELHPACRYDAL 95
CG +++G SG + S +P Y N C+W IT + + + L+F F+LE YD L
Sbjct: 412 CGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERG----YDTL 467
Query: 96 EVF-AGS-GTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS------ 147
V AG G + L G+ P +V+ NQ+ L + +D+ G GF Y
Sbjct: 468 TVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGG 527
Query: 148 ---------GRATSGT---------------------------EHQFCGGR--------- 162
G+ T + +Q+ G +
Sbjct: 528 CGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFF 587
Query: 163 -LEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF 221
+ G + +PN+PE +Y ++C W II+ P I L F FD+EP ++D ++V
Sbjct: 588 NFTASSGIILSPNYPE-EYGNNMNCVWLIISEPGSRIHLIFNDFDVEP----QFDFLAVK 642
Query: 222 NGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKT 272
+ +SD + LG F G+ VP ++S G+ + ++F SD S T GF+ +Y T
Sbjct: 643 DDGISDITV-LGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTT 692
Score = 97.4 bits (241), Expect = 2e-20
Identities = 86/319 (26%), Positives = 118/319 (36%), Gaps = 67/319 (21%)
Query: 9 LLGPLLTACALLPFAQGQTPNYTRP--VFLCGGDVKGESGYVASEGFPNLYPPNKECIWT 66
L G C +P A Q N T P V C G+ G + S G+P Y N CIW
Sbjct: 1774 LQGSTALHCQSVPNALAQW-NDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWK 1832
Query: 67 ITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQ 126
I V EG + + F E + +D+LE+ G + RLG F GT PA L + NQ
Sbjct: 1833 IIVTEGSGIQIQVISFATEQN----WDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQ 1888
Query: 127 VTLRMTTDEGTGGRGFLLWYS-----------------------------------GRAT 151
+ L +D GF L Y G
Sbjct: 1889 LYLHFQSDISVAAAGFHLEYKTVGLAACQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTL 1948
Query: 152 SGTEH-------------------QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIA 192
G H CGG L G + +P +P S YP + C+W I
Sbjct: 1949 QGRSHISCMPGTVRRWNYPSPLCIATCGGTLSTLGGVILSPGFPGS-YPNNLDCTWRISL 2007
Query: 193 PPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELL 252
P + F F E +D + + NG S +G+F G +P ++ S +E L
Sbjct: 2008 PIGYGAHIQFLNFSTE----ANHDFLEIQNGPY-HTSPMIGQFSGTDLPAALLSTTHETL 2062
Query: 253 VQFVSDLSVTADGFSASYK 271
+ F SD S GF +Y+
Sbjct: 2063 IHFYSDHSQNRQGFKLAYQ 2081
Score = 95.1 bits (235), Expect = 1e-19
Identities = 87/321 (27%), Positives = 120/321 (37%), Gaps = 81/321 (25%)
Query: 9 LLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTIT 68
LLG L+ LL A+GQ CGG V+G +G + S GFP+ YP C W I
Sbjct: 13 LLGLLVLCARLLTAAKGQN---------CGGLVQGPNGTIESPGFPHGYPNYANCTWIII 63
Query: 69 VPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVT 128
E + LSF F LE +D L V+ G G R G P+ +V+ G+ +T
Sbjct: 64 TGERNRIQLSFHTFALEED----FDILSVYDGQPQQGNLKVRLSGFQLPSSIVSTGSILT 119
Query: 129 LRMTTDEGTGGRGFLLWYS----------GRATSGTEH---------------------- 156
L TTD +GF Y G G H
Sbjct: 120 LWFTTDFAVSAQGFKALYEVLPSHTCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEG 179
Query: 157 --------------------QFC------GGRLEKAQGTLTTPNWPESDYPPGISCSWHI 190
FC GG L ++++P++P S+Y C+W I
Sbjct: 180 HAILTCIVSPGNGASWDFPAPFCRAEGACGGTLRGTSSSISSPHFP-SEYENNADCTWTI 238
Query: 191 IAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNE 250
+A P IAL F F LE YD + +S G +P + S N
Sbjct: 239 LAEPGDTIALVFTDFQLEEG----YDFLE-----ISGTEAPSIWLTGMNLPSPVISSKNW 289
Query: 251 LLVQFVSDLSVTADGFSASYK 271
L + F SD + GF+A ++
Sbjct: 290 LRLHFTSDSNHRRKGFNAQFQ 310
Score = 89.4 bits (220), Expect = 6e-18
Identities = 72/292 (24%), Positives = 120/292 (41%), Gaps = 70/292 (23%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG + SG + G+P Y + C W I G ++ ++F F E++ YD LE
Sbjct: 759 CGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVN----YDTLE 814
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS--------- 147
V G +S +G + GT P L++ GN + L TTD GFL+ Y
Sbjct: 815 VRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSC 874
Query: 148 ---GRATSGTEH------------------------------------------QFCGGR 162
G +G H CGG
Sbjct: 875 LDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGY 934
Query: 163 LEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF- 221
++ GT+ +P +P+ YP ++C+W I + + + F F LE +D + +
Sbjct: 935 IQGKSGTVLSPGFPDF-YPNSLNCTWTIEVSHGKGVQMIFHTFHLESS----HDYLLITE 989
Query: 222 NGAVSDDSRRLGKFCGDAVPGSISSE--GN-ELLVQFVSDLSVTADGFSASY 270
+G+ S+ RL G +P +I + GN ++F+SD S++ +GF+ ++
Sbjct: 990 DGSFSEPVARL---TGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITF 1038
Score = 83.6 bits (205), Expect = 3e-16
Identities = 88/321 (27%), Positives = 126/321 (39%), Gaps = 80/321 (24%)
Query: 32 RPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACR 91
R V CG VKG G + S FP+ Y N ECI+ I G+ + L R F L
Sbjct: 1100 RCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQL-----FE 1154
Query: 92 YDALEVFAGSGTSGQRLGRFCGTFRPAPLV-----APGNQVTLRMTT------------- 133
D L+V+ G +S + L GTF L+ + N + L T
Sbjct: 1155 GDTLKVYDGKDSSSRPL----GTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTY 1210
Query: 134 ---------DEGTGGRGFLLWYSGRAT-----------------------SGTEHQF--- 158
D G G+ + G T SG +
Sbjct: 1211 TSFDLVKCEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKP 1270
Query: 159 -------CGGRLEKA-QGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPD 210
CGG++ A G + +P +P + Y + C+W I A P + I+L F FD E
Sbjct: 1271 LPSCIAECGGQIHAATSGRILSPGYP-APYDNNLHCTWIIEADPGKTISLHFIVFDTE-- 1327
Query: 211 TYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
+D + V++G V D L ++ G A+P I S N L +QF SD ++ GFS +
Sbjct: 1328 --MAHDILKVWDGPVDSDIL-LKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQF 1384
Query: 271 KTLPRGTAKEGQGPG-PKRGT 290
T T + PG P+ GT
Sbjct: 1385 STSIAATCND---PGMPQNGT 1402
Score = 83.2 bits (204), Expect = 4e-16
Identities = 79/304 (25%), Positives = 116/304 (38%), Gaps = 71/304 (23%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG G G V S +P+ Y + C+++ITVP+ V F F L+ D E
Sbjct: 1626 CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALN-----DLAE 1680
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPL-VAPGNQVTLRMTTDEGTGGRGFLLWYSG-RATSGT 154
+F G+ + L G+ L +A NQ+ LR + G RGF Y TS T
Sbjct: 1681 LFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDT 1740
Query: 155 E--------------HQFCGGRLEK------------------------AQGTLTTPN-- 174
+ +F G + + AQ T P+
Sbjct: 1741 QCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCV 1800
Query: 175 ------------------WPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
+PE Y ++C W II I + F E + +D
Sbjct: 1801 VPCSGNFTQRRGTILSPGYPE-PYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WD 1855
Query: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276
S+ + +G + RLG F G VP ++S N+L + F SD+SV A GF YKT+
Sbjct: 1856 SLEIHDGG-DVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLA 1914
Query: 277 TAKE 280
+E
Sbjct: 1915 ACQE 1918
Score = 81.3 bits (199), Expect = 2e-15
Identities = 84/325 (25%), Positives = 121/325 (37%), Gaps = 69/325 (21%)
Query: 5 ATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECI 64
A L+G + C G P+ VF C + SG + S +P Y N C+
Sbjct: 556 AAFELVGERVITCQQNNQWSGNKPSC---VFSCFFNFTASSGIILSPNYPEEYGNNMNCV 612
Query: 65 WTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPG 124
W I G + L F FD+E ++D L V + LG F G P+ L + G
Sbjct: 613 WLIISEPGSRIHLIFNDFDVEP----QFDFLAVKDDGISDITVLGTFSGNEVPSQLASSG 668
Query: 125 NQVTLRM-----TTDEGTG-----------------------GRGFLLWYSGR------- 149
+ V L TT G G FLL S
Sbjct: 669 HIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGF 728
Query: 150 -ATSGTE--------------------HQFCGGRLEKAQGTLTTPNWPESDYPPGISCSW 188
T G+E CGG L + G + P WP Y + C W
Sbjct: 729 VKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWP-GYYKDSLHCEW 787
Query: 189 HIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEG 248
I A P I +TF++F E YD++ V +G S S +G++ G P + S G
Sbjct: 788 IIEAKPGHSIKITFDRFQTE----VNYDTLEVRDGPAS-SSPLIGEYHGTQAPQFLISTG 842
Query: 249 NELLVQFVSDLSVTADGFSASYKTL 273
N + + F +D S ++ GF Y+++
Sbjct: 843 NFMYLLFTTDNSRSSIGFLIHYESV 867
Score = 75.5 bits (184), Expect = 9e-14
Identities = 83/293 (28%), Positives = 118/293 (40%), Gaps = 70/293 (23%)
Query: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
LCGG ++G+SG V S GFP+ YP + C WTI V G+ V + F F LE +D L
Sbjct: 930 LCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLE----SSHDYL 985
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAP--GN-QVTLRMTTDEGTGGRGFLLWYS----- 147
+ G+ + + R G+ P + A GN LR +D GF + +S
Sbjct: 986 -LITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLE 1044
Query: 148 ------------------GRATSGTEHQFCGGRLEKA----------------------- 166
G S T F G RLE A
Sbjct: 1045 PCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAE 1104
Query: 167 --------QGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
+GTL +PN+P S+Y C + I + I L F L D++
Sbjct: 1105 CGASVKGNEGTLLSPNFP-SNYDNNHECIYKIETEAGKGIHLRTRSFQL-----FEGDTL 1158
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSI-SSEGNELLVQFVSDLSVTADGFSASY 270
V++G S SR LG F + + G I +S N L ++F ++ S T GF +Y
Sbjct: 1159 KVYDGKDS-SSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTY 1210
Score = 74.7 bits (182), Expect = 2e-13
Identities = 46/135 (34%), Positives = 71/135 (52%), Gaps = 6/135 (4%)
Query: 143 LLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTF 202
LL R + + Q CGG ++ GT+ +P +P YP +C+W II I L+F
Sbjct: 16 LLVLCARLLTAAKGQNCGGLVQGPNGTIESPGFPHG-YPNYANCTWIIITGERNRIQLSF 74
Query: 203 EKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVT 262
F LE D +D +SV++G + ++ + G +P SI S G+ L + F +D +V+
Sbjct: 75 HTFALEED----FDILSVYDGQPQQGNLKV-RLSGFQLPSSIVSTGSILTLWFTTDFAVS 129
Query: 263 ADGFSASYKTLPRGT 277
A GF A Y+ LP T
Sbjct: 130 AQGFKALYEVLPSHT 144
Score = 73.6 bits (179), Expect = 4e-13
Identities = 70/287 (24%), Positives = 106/287 (36%), Gaps = 64/287 (22%)
Query: 29 NYTRPVFL--CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLEL 86
NY P+ + CGG + G + S GFP YP N +C W I++P G + F F E
Sbjct: 1965 NYPSPLCIATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTE- 2023
Query: 87 HPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
+D LE+ G + +G+F GT PA L++ ++ + +D +GF L Y
Sbjct: 2024 ---ANHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAY 2080
Query: 147 SG----------------------RATSGTEHQFCGGRLEKAQGTLT-----TPNW---- 175
+ G + LT NW
Sbjct: 2081 QAYELQNCPDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPF 2140
Query: 176 PESD--------------YPPGI--------SCSWHIIAPPDQVIALTFEKFDLEPDTYC 213
P D Y PG C W I PP + + F E
Sbjct: 2141 PRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN-- 2198
Query: 214 RYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLS 260
D ++V++G +S +LG F G+ + S N++L++F SD S
Sbjct: 2199 --DYIAVWDGP-DQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFS 2242
Score = 67.0 bits (162), Expect = 3e-11
Identities = 43/120 (35%), Positives = 62/120 (51%), Gaps = 7/120 (5%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALTFEKFDLEPDTYCRYDS 217
CG L G +T+PN+P Y C W I PD+VI L FE+F+LE YD+
Sbjct: 412 CGSNLRGPSGVITSPNYPVQ-YEDNAHCVWVITTTDPDKVIKLAFEEFELERG----YDT 466
Query: 218 VSVFN-GAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276
++V + G V D L G +VP I S N++ + SD S+ + GF A Y+ + +G
Sbjct: 467 LTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKG 526
Score = 65.5 bits (158), Expect = 1e-10
Identities = 75/309 (24%), Positives = 122/309 (39%), Gaps = 65/309 (21%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLE-----LHPACR 91
CGG++ G +G + S +P YPP KEC W + V ++L F+ F++E LH
Sbjct: 1452 CGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEG 1511
Query: 92 YDALEVFAGSGTSGQR----------------------LGRFCGTFRPAPLVA---PGNQ 126
D+ GS Q L F F+ P A PGN
Sbjct: 1512 EDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNI 1571
Query: 127 VT-LRMTTDEGTGGR-------GFLLWYSGRATS--GTE------------HQFCGGRLE 164
+ R+ TD G G+ + T G + + CGG+
Sbjct: 1572 MNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNAPCGGQYT 1631
Query: 165 KAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGA 224
++G + +PN+P +Y G C + I P + V+ F F + D +F+G
Sbjct: 1632 GSEGVVLSPNYPH-NYTAGQICLYSITVPKEFVVFGQFAYFQTALN-----DLAELFDGT 1685
Query: 225 VSDD---SRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKE- 280
+ S G G+ +P + S N++L++F + +A GF Y+ +PR + +
Sbjct: 1686 HAQARLLSSLSGSHSGETLPLATS---NQILLRFSAKSGASARGFHFVYQAVPRTSDTQC 1742
Query: 281 GQGPGPKRG 289
P P+ G
Sbjct: 1743 SSVPEPRYG 1751
Score = 63.2 bits (152), Expect = 5e-10
Identities = 36/103 (34%), Positives = 52/103 (50%), Gaps = 4/103 (3%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CG +V ++G + S GFP+ YP K+CIW ITVP G V ++F + E D +
Sbjct: 2147 CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTE----AVNDYIA 2202
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGG 139
V+ G + +LG F G + NQV L+ +D GG
Sbjct: 2203 VWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGG 2245
Score = 57.4 bits (137), Expect = 3e-08
Identities = 39/129 (30%), Positives = 58/129 (44%), Gaps = 5/129 (3%)
Query: 43 GESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSG 102
G SG + S G+P Y ++ C W+I V +++ F E ++DALEVF GS
Sbjct: 2328 GSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEK----QFDALEVFDGSS 2383
Query: 103 TSGQRLGRFCGTF-RPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGG 161
L G + + NQ+ LR +TD T +GF + Y+ S T GG
Sbjct: 2384 GQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLKNGG 2443
Query: 162 RLEKAQGTL 170
L + G +
Sbjct: 2444 ILNRTAGAV 2452
>gi|30520377 CUB and zona pellucida-like domains 1 [Homo sapiens]
Length = 607
Score = 108 bits (271), Expect = 8e-24
Identities = 64/216 (29%), Positives = 113/216 (52%), Gaps = 5/216 (2%)
Query: 59 PNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPA 118
P++ C WTI PE +++ + F L+ +C + ++VF G+ ++G LG+ C
Sbjct: 54 PSENCTWTIERPENKSIRIIFSYVQLDPDGSCESENIKVFDGTSSNGPLLGQVCSKNDYV 113
Query: 119 PLV-APGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE 177
P+ + + +T ++ TD R ++Y + CGG L+ +G+ T+PN+P+
Sbjct: 114 PVFESSSSTLTFQIVTDSARIQRTVFVFYY-FFSPNISIPNCGGYLDTLEGSFTSPNYPK 172
Query: 178 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCG 237
+P C WHI D I L F++ LE D C++D +++++G S +S +G+ CG
Sbjct: 173 -PHPELAYCVWHIQVEKDYKIKLNFKEIFLEIDKQCKFDFLAIYDGP-STNSGLIGQVCG 230
Query: 238 DAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTL 273
P + S N L V +D + + GFSASY ++
Sbjct: 231 RVTP-TFESSSNSLTVVLSTDYANSYRGFSASYTSI 265
Score = 65.1 bits (157), Expect = 1e-10
Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 3/121 (2%)
Query: 27 TPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLEL 86
+PN + P CGG + G S +P +P C+W I V + + L+F+ LE+
Sbjct: 146 SPNISIPN--CGGYLDTLEGSFTSPNYPKPHPELAYCVWHIQVEKDYKIKLNFKEIFLEI 203
Query: 87 HPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
C++D L ++ G T+ +G+ CG P + N +T+ ++TD RGF Y
Sbjct: 204 DKQCKFDFLAIYDGPSTNSGLIGQVCGRVTPT-FESSSNSLTVVLSTDYANSYRGFSASY 262
Query: 147 S 147
+
Sbjct: 263 T 263
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo
sapiens]
Length = 3667
Score = 102 bits (253), Expect = 9e-22
Identities = 83/291 (28%), Positives = 125/291 (42%), Gaps = 65/291 (22%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTIT-VPEGQTVSLSFRVFDLELHPACRYDAL 95
CG +++G SG S FP Y N +C+W IT V + + ++F FDLE+ YD L
Sbjct: 508 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEI----GYDTL 563
Query: 96 EVFAGSGTSGQR--LGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY------- 146
+ G R L G+F P +V+ +Q+ L + TDE G GF + Y
Sbjct: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623
Query: 147 -----------------SGRATSGTEHQF----------------------------CGG 161
S R E QF C
Sbjct: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683
Query: 162 RLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF 221
GT+ +P++PE Y ++C W II+ P I L+F FDLE ++D ++V
Sbjct: 684 NFTAPMGTVLSPDYPEG-YGNNLNCIWTIISDPGSRIHLSFNDFDLE----SQFDFLAVK 738
Query: 222 NGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKT 272
+G S +S LG F G VP ++S + L ++F +D S++ GF+ +Y T
Sbjct: 739 DGD-SPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT 788
Score = 99.4 bits (246), Expect = 6e-21
Identities = 84/291 (28%), Positives = 114/291 (39%), Gaps = 66/291 (22%)
Query: 37 CGGDVKGES-GYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
CGG KGES G + S G+P Y N C+W I V G VSL F FD E +D L
Sbjct: 1374 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHDIL 1429
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS-------- 147
V+ G + L G+ P + + N VT++ TD GF + +S
Sbjct: 1430 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1489
Query: 148 ---------------------------GRATSGTEHQFC--------------------G 160
G G E C G
Sbjct: 1490 DPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCG 1549
Query: 161 GRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSV 220
G L + G + +PN+P YP C W I D VI+L F F +EP+ YD + +
Sbjct: 1550 GNLTGSSGFILSPNFPH-PYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLYI 1604
Query: 221 FNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
++G S +S +G F +P I S N + + F SD SV+ GF YK
Sbjct: 1605 YDGPDS-NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYK 1654
Score = 97.4 bits (241), Expect = 2e-20
Identities = 79/313 (25%), Positives = 130/313 (41%), Gaps = 73/313 (23%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG++ G SG++ S FP+ YP +++C WTITV +SL+F F +E + YD L
Sbjct: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS--------- 147
++ G ++ +G F + P + + N + L +D GF L Y
Sbjct: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1663
Query: 148 -GRATSGTE----------------------------------------------HQFCG 160
G +GT H CG
Sbjct: 1664 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCG 1723
Query: 161 GRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSV 220
R ++GT+ +PN+P+ +Y G +C + I P + V+ F F +D V V
Sbjct: 1724 SRSTGSEGTVLSPNYPK-NYSVGHNCVYSIAVPKEFVVFGQFVFFQTS-----LHDVVEV 1777
Query: 221 FNGAVSDD---SRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGT 277
++G S G G+++P S GN++ ++F S +TA GF Y+ +PR +
Sbjct: 1778 YDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1834
Query: 278 AKE-GQGPGPKRG 289
+ + P P+ G
Sbjct: 1835 STQCSSVPEPRFG 1847
Score = 92.8 bits (229), Expect = 6e-19
Identities = 80/300 (26%), Positives = 111/300 (37%), Gaps = 66/300 (22%)
Query: 34 VFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYD 93
+F C + G V S +P Y N CIWTI G + LSF FDLE ++D
Sbjct: 678 IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE----SQFD 733
Query: 94 ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA--- 150
L V G LG F G P+ L + + + L D GRGF + Y+
Sbjct: 734 FLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNE 793
Query: 151 ---------------------------------TSGTEHQFC------------------ 159
T GTE C
Sbjct: 794 CPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA 853
Query: 160 --GGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDS 217
GG G + +P WP Y ++C W I A P I +TFE+F E YD
Sbjct: 854 PCGGHFSAPSGVILSPGWP-GYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDV 908
Query: 218 VSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGT 277
+ V +G + S LG + G VP + S N + + F +D S + +GF Y+++ T
Sbjct: 909 LEVHDGP-NLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 967
Score = 92.4 bits (228), Expect = 7e-19
Identities = 80/319 (25%), Positives = 123/319 (38%), Gaps = 67/319 (21%)
Query: 9 LLGPLLTACALLPFAQGQTPNYTRPVFL--CGGDVKGESGYVASEGFPNLYPPNKECIWT 66
L G + C +P + Q N + P + CGG + G + S G+P Y N C+W
Sbjct: 1870 LHGSIAIRCETVPNSLAQW-NDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWK 1928
Query: 67 ITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQ 126
ITVPEG + + F E + +D+L+ + G + RLG + GT P L + N
Sbjct: 1929 ITVPEGAGIQVQVVSFATEHN----WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNN 1984
Query: 127 VTLRMTTDEGTGGRGFLLWYS-----------------------------------GRAT 151
+ L +D GF L Y+ G +
Sbjct: 1985 LYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSL 2044
Query: 152 SGTEH-------------------QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIA 192
G H CGG + G + +P +P +YP + C+W I
Sbjct: 2045 QGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFP-GNYPSSLDCTWTINL 2103
Query: 193 PPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELL 252
P + L F F E +D + V +G+ S+ S +G+ G +P S+ S +E
Sbjct: 2104 PIGFGVHLQFVNFSTE----TIHDYLEVRSGS-SETSTVIGRLSGPQIPSSLFSTTHETS 2158
Query: 253 VQFVSDLSVTADGFSASYK 271
+ F SD S GF Y+
Sbjct: 2159 LYFHSDYSQNKQGFHIVYQ 2177
Score = 83.6 bits (205), Expect = 3e-16
Identities = 72/292 (24%), Positives = 114/292 (39%), Gaps = 70/292 (23%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG SG + S G+P Y + C W I G ++ ++F F EL+ YD LE
Sbjct: 855 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLE 910
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY---------- 146
V G LG + GT P L + N + L TTD GF + Y
Sbjct: 911 VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 970
Query: 147 ---------------------------SGRATSGTEHQFC-----------------GGR 162
SG S E C GG
Sbjct: 971 LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGD 1030
Query: 163 LEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF- 221
+ GT+ +P +PE YP ++C+W + + + F F LE +D + +
Sbjct: 1031 VRGPSGTILSPGYPEF-YPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLLITE 1085
Query: 222 NGAVSDDSRRLGKFCGDAVPGSISS--EGN-ELLVQFVSDLSVTADGFSASY 270
NG+ ++ L + G +P +I++ GN ++F+SD S++ +GF+ ++
Sbjct: 1086 NGSF---TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1134
Score = 78.2 bits (191), Expect = 1e-14
Identities = 78/293 (26%), Positives = 117/293 (39%), Gaps = 70/293 (23%)
Query: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
LCGGDV+G SG + S G+P YP + C WT+ V G+ V +F F LE H +D L
Sbjct: 1026 LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYL 1081
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAP--GN-QVTLRMTTDEGTGGRGFLLWY------ 146
+ +G+ Q L R G+ P + A GN + LR +D GF + +
Sbjct: 1082 -LITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLE 1140
Query: 147 -----------------------------SGRATSGTEHQFC--GGR------------- 162
SG GT C GGR
Sbjct: 1141 PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAE 1200
Query: 163 ----LEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
+G L +PN+P +Y C + I + I ++ F L + D +
Sbjct: 1201 CGASATNNEGILLSPNYP-LNYENNHECIYSIQVQAGKGINISARTFHL-----AQGDVL 1254
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPG-SISSEGNELLVQFVSDLSVTADGFSASY 270
+++G + LG F G ++ G ++SS N+L ++F SD T +GF Y
Sbjct: 1255 KIYDGK-DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1306
Score = 72.8 bits (177), Expect = 6e-13
Identities = 47/135 (34%), Positives = 64/135 (47%), Gaps = 10/135 (7%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG ++G SG ++S FPN Y N +C WTI G T+SL F F +E +YD LE
Sbjct: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLE 256
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
+ G+ + G P P+++ N + L TD RGF Y G +T H
Sbjct: 257 I---EGSEPPTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSST--LTH 310
Query: 157 QFCGGRLEKAQGTLT 171
G LE+ T T
Sbjct: 311 TTSTGELEEHNRTTT 325
Score = 72.0 bits (175), Expect = 1e-12
Identities = 41/126 (32%), Positives = 65/126 (51%), Gaps = 6/126 (4%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG L K +GT+ +P +PE Y ++C W I P I + F E + +DS+
Sbjct: 1899 CGGILTKRKGTILSPGYPEP-YDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSL 1953
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278
++G +++ RLG + G +P ++S N L + F SD+SV+A GF Y + +
Sbjct: 1954 DFYDGG-DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSC 2012
Query: 279 KEGQGP 284
E Q P
Sbjct: 2013 PEPQTP 2018
Score = 65.5 bits (158), Expect = 1e-10
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 34 VFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYD 93
++ CGG +KG +G + S GFP YP C W I E + + F+ F LE YD
Sbjct: 22 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYD 77
Query: 94 ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
L ++ G R G P P+ + + +LR+T+D GF ++Y
Sbjct: 78 YLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 130
Score = 65.1 bits (157), Expect = 1e-10
Identities = 37/133 (27%), Positives = 66/133 (49%), Gaps = 8/133 (6%)
Query: 11 GPLLTACALLPFAQGQTPNYTRPV----FLCGGDVKGESGYVASEGFPNLYPPNKECIWT 66
G L + L G + N+ P+ LCGG++ +G + S G+P+ YP ++C W
Sbjct: 2213 GYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL 2272
Query: 67 ITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQ 126
+ VP G + ++F V L+ P YD + V+ G + ++G+F G + + NQ
Sbjct: 2273 VRVPPGNGIYINFTV--LQTEPI--YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQ 2328
Query: 127 VTLRMTTDEGTGG 139
+ ++ +D T G
Sbjct: 2329 ILIKFHSDFTTSG 2341
Score = 63.5 bits (153), Expect = 4e-10
Identities = 42/135 (31%), Positives = 67/135 (49%), Gaps = 9/135 (6%)
Query: 142 FLLWYSGRATSGTEHQF---CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVI 198
FL W + T F CGG L+ GT+ +P +P YP G +C+W IIA I
Sbjct: 5 FLCWKPVQLDRQTASGFIYTCGGTLKGLNGTIESPGFPYG-YPNGANCTWVIIAEERNRI 63
Query: 199 ALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSD 258
+ F+ F LE + YD +S+++G + R + G +P ++S + ++ SD
Sbjct: 64 QIVFQSFALEEE----YDYLSLYDGHPHPTNFRT-RLTGFHLPPPVTSTKSVFSLRLTSD 118
Query: 259 LSVTADGFSASYKTL 273
+V+A GF Y+ L
Sbjct: 119 FAVSAHGFKVYYEEL 133
Score = 62.0 bits (149), Expect = 1e-09
Identities = 36/112 (32%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG + GT+ +P +P+ +YP C W + PP I + F EP YD +
Sbjct: 2243 CGGNITAMNGTIYSPGYPD-EYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFI 2297
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
+V++G +S ++G+F G+ S+ S N++L++F SD + T+ F SY
Sbjct: 2298 TVWDGP-DQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFT-TSGFFVLSY 2347
Score = 60.8 bits (146), Expect = 2e-09
Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 7/119 (5%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALTFEKFDLEPDTYCRYDS 217
CG L+ GT T+PN+P Y C W I A ++VI + FE+FDLE YD+
Sbjct: 508 CGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 562
Query: 218 VSVFNGAVSDDSRR-LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPR 275
+++ +G D R L G VP I S +++ + +D SV + GF +YK + +
Sbjct: 563 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 621
Score = 55.5 bits (132), Expect = 1e-07
Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 32 RPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACR 91
R V CG G + S +P Y N ECI++I V G+ +++S R F L +
Sbjct: 1196 RCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQ 1250
Query: 92 YDALEVFAGSGTSGQRLGRFCG-TFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA 150
D L+++ G + LG F G + R L + NQ+ L +D GF L Y+
Sbjct: 1251 GDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFE 1310
Query: 151 TSGTE 155
S E
Sbjct: 1311 LSHCE 1315
Score = 54.7 bits (130), Expect = 2e-07
Identities = 38/134 (28%), Positives = 64/134 (47%), Gaps = 11/134 (8%)
Query: 159 CGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDS 217
CGGR + ++ G + +P +P Y + C W I P +++L F FD E +D
Sbjct: 1374 CGGRFKGESSGRILSPGYP-FPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHDI 1428
Query: 218 VSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGT 277
+ V++G +D L + G +P I S N + +QF +D ++ GF+ + +
Sbjct: 1429 LRVWDGPPEND-MLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSS---SV 1484
Query: 278 AKEGQGPG-PKRGT 290
A + PG P GT
Sbjct: 1485 ATACRDPGVPMNGT 1498
Score = 52.0 bits (123), Expect = 1e-06
Identities = 33/113 (29%), Positives = 54/113 (47%), Gaps = 10/113 (8%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG + + G +++P++P ++Y C+W I+A P I+L F F +E +YD +
Sbjct: 201 CGGTMRGSSGIISSPSFP-NEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 255
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
+ G +P I S N L + FV+D + GFSA Y+
Sbjct: 256 E-----IEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303
Score = 51.6 bits (122), Expect = 1e-06
Identities = 28/103 (27%), Positives = 51/103 (49%), Gaps = 5/103 (4%)
Query: 45 SGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTS 104
+G + S G+P+ YP + C W+I+V +G +++ F E +D L+V+ G
Sbjct: 2426 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQ 2481
Query: 105 GQRLGRFCGTFRPA-PLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
L G + A + + G++V L+ + D G +GF + Y
Sbjct: 2482 SPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRY 2524
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 102 bits (253), Expect = 9e-22
Identities = 83/291 (28%), Positives = 125/291 (42%), Gaps = 65/291 (22%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTIT-VPEGQTVSLSFRVFDLELHPACRYDAL 95
CG +++G SG S FP Y N +C+W IT V + + ++F FDLE+ YD L
Sbjct: 444 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEI----GYDTL 499
Query: 96 EVFAGSGTSGQR--LGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY------- 146
+ G R L G+F P +V+ +Q+ L + TDE G GF + Y
Sbjct: 500 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 559
Query: 147 -----------------SGRATSGTEHQF----------------------------CGG 161
S R E QF C
Sbjct: 560 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 619
Query: 162 RLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF 221
GT+ +P++PE Y ++C W II+ P I L+F FDLE ++D ++V
Sbjct: 620 NFTAPMGTVLSPDYPEG-YGNNLNCIWTIISDPGSRIHLSFNDFDLE----SQFDFLAVK 674
Query: 222 NGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKT 272
+G S +S LG F G VP ++S + L ++F +D S++ GF+ +Y T
Sbjct: 675 DGD-SPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT 724
Score = 99.4 bits (246), Expect = 6e-21
Identities = 84/291 (28%), Positives = 114/291 (39%), Gaps = 66/291 (22%)
Query: 37 CGGDVKGES-GYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
CGG KGES G + S G+P Y N C+W I V G VSL F FD E +D L
Sbjct: 1310 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHDIL 1365
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS-------- 147
V+ G + L G+ P + + N VT++ TD GF + +S
Sbjct: 1366 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1425
Query: 148 ---------------------------GRATSGTEHQFC--------------------G 160
G G E C G
Sbjct: 1426 DPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCG 1485
Query: 161 GRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSV 220
G L + G + +PN+P YP C W I D VI+L F F +EP+ YD + +
Sbjct: 1486 GNLTGSSGFILSPNFPH-PYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLYI 1540
Query: 221 FNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
++G S +S +G F +P I S N + + F SD SV+ GF YK
Sbjct: 1541 YDGPDS-NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYK 1590
Score = 97.4 bits (241), Expect = 2e-20
Identities = 79/313 (25%), Positives = 130/313 (41%), Gaps = 73/313 (23%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG++ G SG++ S FP+ YP +++C WTITV +SL+F F +E + YD L
Sbjct: 1484 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1539
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS--------- 147
++ G ++ +G F + P + + N + L +D GF L Y
Sbjct: 1540 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1599
Query: 148 -GRATSGTE----------------------------------------------HQFCG 160
G +GT H CG
Sbjct: 1600 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCG 1659
Query: 161 GRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSV 220
R ++GT+ +PN+P+ +Y G +C + I P + V+ F F +D V V
Sbjct: 1660 SRSTGSEGTVLSPNYPK-NYSVGHNCVYSIAVPKEFVVFGQFVFFQTS-----LHDVVEV 1713
Query: 221 FNGAVSDD---SRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGT 277
++G S G G+++P S GN++ ++F S +TA GF Y+ +PR +
Sbjct: 1714 YDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1770
Query: 278 AKE-GQGPGPKRG 289
+ + P P+ G
Sbjct: 1771 STQCSSVPEPRFG 1783
Score = 92.8 bits (229), Expect = 6e-19
Identities = 80/300 (26%), Positives = 111/300 (37%), Gaps = 66/300 (22%)
Query: 34 VFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYD 93
+F C + G V S +P Y N CIWTI G + LSF FDLE ++D
Sbjct: 614 IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE----SQFD 669
Query: 94 ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA--- 150
L V G LG F G P+ L + + + L D GRGF + Y+
Sbjct: 670 FLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNE 729
Query: 151 ---------------------------------TSGTEHQFC------------------ 159
T GTE C
Sbjct: 730 CPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA 789
Query: 160 --GGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDS 217
GG G + +P WP Y ++C W I A P I +TFE+F E YD
Sbjct: 790 PCGGHFSAPSGVILSPGWP-GYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDV 844
Query: 218 VSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGT 277
+ V +G + S LG + G VP + S N + + F +D S + +GF Y+++ T
Sbjct: 845 LEVHDGP-NLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 903
Score = 92.4 bits (228), Expect = 7e-19
Identities = 80/319 (25%), Positives = 123/319 (38%), Gaps = 67/319 (21%)
Query: 9 LLGPLLTACALLPFAQGQTPNYTRPVFL--CGGDVKGESGYVASEGFPNLYPPNKECIWT 66
L G + C +P + Q N + P + CGG + G + S G+P Y N C+W
Sbjct: 1806 LHGSIAIRCETVPNSLAQW-NDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWK 1864
Query: 67 ITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQ 126
ITVPEG + + F E + +D+L+ + G + RLG + GT P L + N
Sbjct: 1865 ITVPEGAGIQVQVVSFATEHN----WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNN 1920
Query: 127 VTLRMTTDEGTGGRGFLLWYS-----------------------------------GRAT 151
+ L +D GF L Y+ G +
Sbjct: 1921 LYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSL 1980
Query: 152 SGTEH-------------------QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIA 192
G H CGG + G + +P +P +YP + C+W I
Sbjct: 1981 QGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFP-GNYPSSLDCTWTINL 2039
Query: 193 PPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELL 252
P + L F F E +D + V +G+ S+ S +G+ G +P S+ S +E
Sbjct: 2040 PIGFGVHLQFVNFSTE----TIHDYLEVRSGS-SETSTVIGRLSGPQIPSSLFSTTHETS 2094
Query: 253 VQFVSDLSVTADGFSASYK 271
+ F SD S GF Y+
Sbjct: 2095 LYFHSDYSQNKQGFHIVYQ 2113
Score = 83.6 bits (205), Expect = 3e-16
Identities = 72/292 (24%), Positives = 114/292 (39%), Gaps = 70/292 (23%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG SG + S G+P Y + C W I G ++ ++F F EL+ YD LE
Sbjct: 791 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLE 846
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY---------- 146
V G LG + GT P L + N + L TTD GF + Y
Sbjct: 847 VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 906
Query: 147 ---------------------------SGRATSGTEHQFC-----------------GGR 162
SG S E C GG
Sbjct: 907 LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGD 966
Query: 163 LEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF- 221
+ GT+ +P +PE YP ++C+W + + + F F LE +D + +
Sbjct: 967 VRGPSGTILSPGYPEF-YPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLLITE 1021
Query: 222 NGAVSDDSRRLGKFCGDAVPGSISS--EGN-ELLVQFVSDLSVTADGFSASY 270
NG+ ++ L + G +P +I++ GN ++F+SD S++ +GF+ ++
Sbjct: 1022 NGSF---TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1070
Score = 78.2 bits (191), Expect = 1e-14
Identities = 78/293 (26%), Positives = 117/293 (39%), Gaps = 70/293 (23%)
Query: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
LCGGDV+G SG + S G+P YP + C WT+ V G+ V +F F LE H +D L
Sbjct: 962 LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYL 1017
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAP--GN-QVTLRMTTDEGTGGRGFLLWY------ 146
+ +G+ Q L R G+ P + A GN + LR +D GF + +
Sbjct: 1018 -LITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLE 1076
Query: 147 -----------------------------SGRATSGTEHQFC--GGR------------- 162
SG GT C GGR
Sbjct: 1077 PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAE 1136
Query: 163 ----LEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
+G L +PN+P +Y C + I + I ++ F L + D +
Sbjct: 1137 CGASATNNEGILLSPNYP-LNYENNHECIYSIQVQAGKGINISARTFHL-----AQGDVL 1190
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPG-SISSEGNELLVQFVSDLSVTADGFSASY 270
+++G + LG F G ++ G ++SS N+L ++F SD T +GF Y
Sbjct: 1191 KIYDGK-DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1242
Score = 72.0 bits (175), Expect = 1e-12
Identities = 41/126 (32%), Positives = 65/126 (51%), Gaps = 6/126 (4%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG L K +GT+ +P +PE Y ++C W I P I + F E + +DS+
Sbjct: 1835 CGGILTKRKGTILSPGYPEP-YDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSL 1889
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278
++G +++ RLG + G +P ++S N L + F SD+SV+A GF Y + +
Sbjct: 1890 DFYDGG-DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSC 1948
Query: 279 KEGQGP 284
E Q P
Sbjct: 1949 PEPQTP 1954
Score = 65.5 bits (158), Expect = 1e-10
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 34 VFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYD 93
++ CGG +KG +G + S GFP YP C W I E + + F+ F LE YD
Sbjct: 62 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYD 117
Query: 94 ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
L ++ G R G P P+ + + +LR+T+D GF ++Y
Sbjct: 118 YLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Score = 65.5 bits (158), Expect = 1e-10
Identities = 38/106 (35%), Positives = 53/106 (50%), Gaps = 8/106 (7%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG ++G SG ++S FPN Y N +C WTI G T+SL F F +E +YD LE
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLE 296
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF 142
+ G+ + G P P+++ N + L TD RGF
Sbjct: 297 I---EGSEPPTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGF 338
Score = 65.1 bits (157), Expect = 1e-10
Identities = 37/133 (27%), Positives = 66/133 (49%), Gaps = 8/133 (6%)
Query: 11 GPLLTACALLPFAQGQTPNYTRPV----FLCGGDVKGESGYVASEGFPNLYPPNKECIWT 66
G L + L G + N+ P+ LCGG++ +G + S G+P+ YP ++C W
Sbjct: 2149 GYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL 2208
Query: 67 ITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQ 126
+ VP G + ++F V L+ P YD + V+ G + ++G+F G + + NQ
Sbjct: 2209 VRVPPGNGIYINFTV--LQTEPI--YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQ 2264
Query: 127 VTLRMTTDEGTGG 139
+ ++ +D T G
Sbjct: 2265 ILIKFHSDFTTSG 2277
Score = 62.4 bits (150), Expect = 8e-10
Identities = 37/115 (32%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG L+ GT+ +P +P YP G +C+W IIA I + F+ F LE + YD +
Sbjct: 65 CGGTLKGLNGTIESPGFPYG-YPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYL 119
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTL 273
S+++G + R + G +P ++S + ++ SD +V+A GF Y+ L
Sbjct: 120 SLYDGHPHPTNFRT-RLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEEL 173
Score = 62.0 bits (149), Expect = 1e-09
Identities = 36/112 (32%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG + GT+ +P +P+ +YP C W + PP I + F EP YD +
Sbjct: 2179 CGGNITAMNGTIYSPGYPD-EYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFI 2233
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
+V++G +S ++G+F G+ S+ S N++L++F SD + T+ F SY
Sbjct: 2234 TVWDGP-DQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFT-TSGFFVLSY 2283
Score = 60.8 bits (146), Expect = 2e-09
Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 7/119 (5%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALTFEKFDLEPDTYCRYDS 217
CG L+ GT T+PN+P Y C W I A ++VI + FE+FDLE YD+
Sbjct: 444 CGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 498
Query: 218 VSVFNGAVSDDSRR-LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPR 275
+++ +G D R L G VP I S +++ + +D SV + GF +YK + +
Sbjct: 499 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 557
Score = 55.5 bits (132), Expect = 1e-07
Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 32 RPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACR 91
R V CG G + S +P Y N ECI++I V G+ +++S R F L +
Sbjct: 1132 RCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQ 1186
Query: 92 YDALEVFAGSGTSGQRLGRFCG-TFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA 150
D L+++ G + LG F G + R L + NQ+ L +D GF L Y+
Sbjct: 1187 GDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFE 1246
Query: 151 TSGTE 155
S E
Sbjct: 1247 LSHCE 1251
Score = 54.7 bits (130), Expect = 2e-07
Identities = 38/134 (28%), Positives = 64/134 (47%), Gaps = 11/134 (8%)
Query: 159 CGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDS 217
CGGR + ++ G + +P +P Y + C W I P +++L F FD E +D
Sbjct: 1310 CGGRFKGESSGRILSPGYP-FPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHDI 1364
Query: 218 VSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGT 277
+ V++G +D L + G +P I S N + +QF +D ++ GF+ + +
Sbjct: 1365 LRVWDGPPEND-MLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSS---SV 1420
Query: 278 AKEGQGPG-PKRGT 290
A + PG P GT
Sbjct: 1421 ATACRDPGVPMNGT 1434
Score = 52.0 bits (123), Expect = 1e-06
Identities = 33/113 (29%), Positives = 54/113 (47%), Gaps = 10/113 (8%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG + + G +++P++P ++Y C+W I+A P I+L F F +E +YD +
Sbjct: 241 CGGTMRGSSGIISSPSFP-NEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 295
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
+ G +P I S N L + FV+D + GFSA Y+
Sbjct: 296 E-----IEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Score = 51.6 bits (122), Expect = 1e-06
Identities = 28/103 (27%), Positives = 51/103 (49%), Gaps = 5/103 (4%)
Query: 45 SGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTS 104
+G + S G+P+ YP + C W+I+V +G +++ F E +D L+V+ G
Sbjct: 2362 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQ 2417
Query: 105 GQRLGRFCGTFRPA-PLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
L G + A + + G++V L+ + D G +GF + Y
Sbjct: 2418 SPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRY 2460
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo
sapiens]
Length = 3707
Score = 102 bits (253), Expect = 9e-22
Identities = 83/291 (28%), Positives = 125/291 (42%), Gaps = 65/291 (22%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTIT-VPEGQTVSLSFRVFDLELHPACRYDAL 95
CG +++G SG S FP Y N +C+W IT V + + ++F FDLE+ YD L
Sbjct: 548 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEI----GYDTL 603
Query: 96 EVFAGSGTSGQR--LGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY------- 146
+ G R L G+F P +V+ +Q+ L + TDE G GF + Y
Sbjct: 604 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 663
Query: 147 -----------------SGRATSGTEHQF----------------------------CGG 161
S R E QF C
Sbjct: 664 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 723
Query: 162 RLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF 221
GT+ +P++PE Y ++C W II+ P I L+F FDLE ++D ++V
Sbjct: 724 NFTAPMGTVLSPDYPEG-YGNNLNCIWTIISDPGSRIHLSFNDFDLE----SQFDFLAVK 778
Query: 222 NGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKT 272
+G S +S LG F G VP ++S + L ++F +D S++ GF+ +Y T
Sbjct: 779 DGD-SPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT 828
Score = 99.4 bits (246), Expect = 6e-21
Identities = 84/291 (28%), Positives = 114/291 (39%), Gaps = 66/291 (22%)
Query: 37 CGGDVKGES-GYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
CGG KGES G + S G+P Y N C+W I V G VSL F FD E +D L
Sbjct: 1414 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHDIL 1469
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS-------- 147
V+ G + L G+ P + + N VT++ TD GF + +S
Sbjct: 1470 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1529
Query: 148 ---------------------------GRATSGTEHQFC--------------------G 160
G G E C G
Sbjct: 1530 DPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCG 1589
Query: 161 GRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSV 220
G L + G + +PN+P YP C W I D VI+L F F +EP+ YD + +
Sbjct: 1590 GNLTGSSGFILSPNFPH-PYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLYI 1644
Query: 221 FNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
++G S +S +G F +P I S N + + F SD SV+ GF YK
Sbjct: 1645 YDGPDS-NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYK 1694
Score = 97.4 bits (241), Expect = 2e-20
Identities = 79/313 (25%), Positives = 130/313 (41%), Gaps = 73/313 (23%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG++ G SG++ S FP+ YP +++C WTITV +SL+F F +E + YD L
Sbjct: 1588 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1643
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS--------- 147
++ G ++ +G F + P + + N + L +D GF L Y
Sbjct: 1644 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1703
Query: 148 -GRATSGTE----------------------------------------------HQFCG 160
G +GT H CG
Sbjct: 1704 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCG 1763
Query: 161 GRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSV 220
R ++GT+ +PN+P+ +Y G +C + I P + V+ F F +D V V
Sbjct: 1764 SRSTGSEGTVLSPNYPK-NYSVGHNCVYSIAVPKEFVVFGQFVFFQTS-----LHDVVEV 1817
Query: 221 FNGAVSDD---SRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGT 277
++G S G G+++P S GN++ ++F S +TA GF Y+ +PR +
Sbjct: 1818 YDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1874
Query: 278 AKE-GQGPGPKRG 289
+ + P P+ G
Sbjct: 1875 STQCSSVPEPRFG 1887
Score = 92.8 bits (229), Expect = 6e-19
Identities = 80/300 (26%), Positives = 111/300 (37%), Gaps = 66/300 (22%)
Query: 34 VFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYD 93
+F C + G V S +P Y N CIWTI G + LSF FDLE ++D
Sbjct: 718 IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE----SQFD 773
Query: 94 ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA--- 150
L V G LG F G P+ L + + + L D GRGF + Y+
Sbjct: 774 FLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNE 833
Query: 151 ---------------------------------TSGTEHQFC------------------ 159
T GTE C
Sbjct: 834 CPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA 893
Query: 160 --GGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDS 217
GG G + +P WP Y ++C W I A P I +TFE+F E YD
Sbjct: 894 PCGGHFSAPSGVILSPGWP-GYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDV 948
Query: 218 VSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGT 277
+ V +G + S LG + G VP + S N + + F +D S + +GF Y+++ T
Sbjct: 949 LEVHDGP-NLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 1007
Score = 92.4 bits (228), Expect = 7e-19
Identities = 80/319 (25%), Positives = 123/319 (38%), Gaps = 67/319 (21%)
Query: 9 LLGPLLTACALLPFAQGQTPNYTRPVFL--CGGDVKGESGYVASEGFPNLYPPNKECIWT 66
L G + C +P + Q N + P + CGG + G + S G+P Y N C+W
Sbjct: 1910 LHGSIAIRCETVPNSLAQW-NDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWK 1968
Query: 67 ITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQ 126
ITVPEG + + F E + +D+L+ + G + RLG + GT P L + N
Sbjct: 1969 ITVPEGAGIQVQVVSFATEHN----WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNN 2024
Query: 127 VTLRMTTDEGTGGRGFLLWYS-----------------------------------GRAT 151
+ L +D GF L Y+ G +
Sbjct: 2025 LYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSL 2084
Query: 152 SGTEH-------------------QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIA 192
G H CGG + G + +P +P +YP + C+W I
Sbjct: 2085 QGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFP-GNYPSSLDCTWTINL 2143
Query: 193 PPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELL 252
P + L F F E +D + V +G+ S+ S +G+ G +P S+ S +E
Sbjct: 2144 PIGFGVHLQFVNFSTE----TIHDYLEVRSGS-SETSTVIGRLSGPQIPSSLFSTTHETS 2198
Query: 253 VQFVSDLSVTADGFSASYK 271
+ F SD S GF Y+
Sbjct: 2199 LYFHSDYSQNKQGFHIVYQ 2217
Score = 83.6 bits (205), Expect = 3e-16
Identities = 72/292 (24%), Positives = 114/292 (39%), Gaps = 70/292 (23%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG SG + S G+P Y + C W I G ++ ++F F EL+ YD LE
Sbjct: 895 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLE 950
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY---------- 146
V G LG + GT P L + N + L TTD GF + Y
Sbjct: 951 VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 1010
Query: 147 ---------------------------SGRATSGTEHQFC-----------------GGR 162
SG S E C GG
Sbjct: 1011 LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGD 1070
Query: 163 LEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF- 221
+ GT+ +P +PE YP ++C+W + + + F F LE +D + +
Sbjct: 1071 VRGPSGTILSPGYPEF-YPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLLITE 1125
Query: 222 NGAVSDDSRRLGKFCGDAVPGSISS--EGN-ELLVQFVSDLSVTADGFSASY 270
NG+ ++ L + G +P +I++ GN ++F+SD S++ +GF+ ++
Sbjct: 1126 NGSF---TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1174
Score = 78.2 bits (191), Expect = 1e-14
Identities = 78/293 (26%), Positives = 117/293 (39%), Gaps = 70/293 (23%)
Query: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
LCGGDV+G SG + S G+P YP + C WT+ V G+ V +F F LE H +D L
Sbjct: 1066 LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYL 1121
Query: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAP--GN-QVTLRMTTDEGTGGRGFLLWY------ 146
+ +G+ Q L R G+ P + A GN + LR +D GF + +
Sbjct: 1122 -LITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLE 1180
Query: 147 -----------------------------SGRATSGTEHQFC--GGR------------- 162
SG GT C GGR
Sbjct: 1181 PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAE 1240
Query: 163 ----LEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
+G L +PN+P +Y C + I + I ++ F L + D +
Sbjct: 1241 CGASATNNEGILLSPNYP-LNYENNHECIYSIQVQAGKGINISARTFHL-----AQGDVL 1294
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPG-SISSEGNELLVQFVSDLSVTADGFSASY 270
+++G + LG F G ++ G ++SS N+L ++F SD T +GF Y
Sbjct: 1295 KIYDGK-DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1346
Score = 72.8 bits (177), Expect = 6e-13
Identities = 47/135 (34%), Positives = 64/135 (47%), Gaps = 10/135 (7%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
CGG ++G SG ++S FPN Y N +C WTI G T+SL F F +E +YD LE
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLE 296
Query: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
+ G+ + G P P+++ N + L TD RGF Y G +T H
Sbjct: 297 I---EGSEPPTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSST--LTH 350
Query: 157 QFCGGRLEKAQGTLT 171
G LE+ T T
Sbjct: 351 TTSTGELEEHNRTTT 365
Score = 72.0 bits (175), Expect = 1e-12
Identities = 41/126 (32%), Positives = 65/126 (51%), Gaps = 6/126 (4%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG L K +GT+ +P +PE Y ++C W I P I + F E + +DS+
Sbjct: 1939 CGGILTKRKGTILSPGYPEP-YDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSL 1993
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278
++G +++ RLG + G +P ++S N L + F SD+SV+A GF Y + +
Sbjct: 1994 DFYDGG-DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSC 2052
Query: 279 KEGQGP 284
E Q P
Sbjct: 2053 PEPQTP 2058
Score = 65.5 bits (158), Expect = 1e-10
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 34 VFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYD 93
++ CGG +KG +G + S GFP YP C W I E + + F+ F LE YD
Sbjct: 62 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYD 117
Query: 94 ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
L ++ G R G P P+ + + +LR+T+D GF ++Y
Sbjct: 118 YLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Score = 65.1 bits (157), Expect = 1e-10
Identities = 37/133 (27%), Positives = 66/133 (49%), Gaps = 8/133 (6%)
Query: 11 GPLLTACALLPFAQGQTPNYTRPV----FLCGGDVKGESGYVASEGFPNLYPPNKECIWT 66
G L + L G + N+ P+ LCGG++ +G + S G+P+ YP ++C W
Sbjct: 2253 GYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL 2312
Query: 67 ITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQ 126
+ VP G + ++F V L+ P YD + V+ G + ++G+F G + + NQ
Sbjct: 2313 VRVPPGNGIYINFTV--LQTEPI--YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQ 2368
Query: 127 VTLRMTTDEGTGG 139
+ ++ +D T G
Sbjct: 2369 ILIKFHSDFTTSG 2381
Score = 62.4 bits (150), Expect = 8e-10
Identities = 37/115 (32%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG L+ GT+ +P +P YP G +C+W IIA I + F+ F LE + YD +
Sbjct: 65 CGGTLKGLNGTIESPGFPYG-YPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYL 119
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTL 273
S+++G + R + G +P ++S + ++ SD +V+A GF Y+ L
Sbjct: 120 SLYDGHPHPTNFRT-RLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEEL 173
Score = 62.0 bits (149), Expect = 1e-09
Identities = 36/112 (32%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG + GT+ +P +P+ +YP C W + PP I + F EP YD +
Sbjct: 2283 CGGNITAMNGTIYSPGYPD-EYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFI 2337
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
+V++G +S ++G+F G+ S+ S N++L++F SD + T+ F SY
Sbjct: 2338 TVWDGP-DQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFT-TSGFFVLSY 2387
Score = 60.8 bits (146), Expect = 2e-09
Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 7/119 (5%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALTFEKFDLEPDTYCRYDS 217
CG L+ GT T+PN+P Y C W I A ++VI + FE+FDLE YD+
Sbjct: 548 CGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 602
Query: 218 VSVFNGAVSDDSRR-LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPR 275
+++ +G D R L G VP I S +++ + +D SV + GF +YK + +
Sbjct: 603 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 661
Score = 55.5 bits (132), Expect = 1e-07
Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 32 RPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACR 91
R V CG G + S +P Y N ECI++I V G+ +++S R F L +
Sbjct: 1236 RCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQ 1290
Query: 92 YDALEVFAGSGTSGQRLGRFCG-TFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA 150
D L+++ G + LG F G + R L + NQ+ L +D GF L Y+
Sbjct: 1291 GDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFE 1350
Query: 151 TSGTE 155
S E
Sbjct: 1351 LSHCE 1355
Score = 54.7 bits (130), Expect = 2e-07
Identities = 38/134 (28%), Positives = 64/134 (47%), Gaps = 11/134 (8%)
Query: 159 CGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDS 217
CGGR + ++ G + +P +P Y + C W I P +++L F FD E +D
Sbjct: 1414 CGGRFKGESSGRILSPGYP-FPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHDI 1468
Query: 218 VSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGT 277
+ V++G +D L + G +P I S N + +QF +D ++ GF+ + +
Sbjct: 1469 LRVWDGPPEND-MLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSS---SV 1524
Query: 278 AKEGQGPG-PKRGT 290
A + PG P GT
Sbjct: 1525 ATACRDPGVPMNGT 1538
Score = 52.0 bits (123), Expect = 1e-06
Identities = 33/113 (29%), Positives = 54/113 (47%), Gaps = 10/113 (8%)
Query: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
CGG + + G +++P++P ++Y C+W I+A P I+L F F +E +YD +
Sbjct: 241 CGGTMRGSSGIISSPSFP-NEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 295
Query: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
+ G +P I S N L + FV+D + GFSA Y+
Sbjct: 296 E-----IEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Score = 51.6 bits (122), Expect = 1e-06
Identities = 28/103 (27%), Positives = 51/103 (49%), Gaps = 5/103 (4%)
Query: 45 SGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTS 104
+G + S G+P+ YP + C W+I+V +G +++ F E +D L+V+ G
Sbjct: 2466 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQ 2521
Query: 105 GQRLGRFCGTFRPA-PLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
L G + A + + G++V L+ + D G +GF + Y
Sbjct: 2522 SPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRY 2564
>gi|148231605 ovochymase 2 [Homo sapiens]
Length = 564
Score = 93.6 bits (231), Expect = 3e-19
Identities = 59/224 (26%), Positives = 104/224 (46%), Gaps = 10/224 (4%)
Query: 57 YPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFR 116
Y + C+WT+ VPE V LSF D+E +C + L +++ + +G+FCG
Sbjct: 335 YESKQRCVWTLLVPEEMHVLLSFSHLDVE---SCHHSYLSMYS---LEDRPIGKFCGESL 388
Query: 117 PAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGG-RLEKAQGTLTTPNW 175
P+ ++ N + L+ +D GF L Y + C + +G + + N+
Sbjct: 389 PSSILIGSNSLRLKFVSDATDNAAGFNLTYKALKPNYIPDSGCSYLTVLFEEGLIQSLNY 448
Query: 176 PESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKF 235
PE+ Y +C W A +I L+F+ ++E C D V+V + + + + +
Sbjct: 449 PEN-YSDKANCDWIFQASKHHLIKLSFQSLEIEESGDCTSDYVTVHSDV--ERKKEIARL 505
Query: 236 CGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAK 279
CG VP + S + +L+ F SD + T GF A+ +P+ K
Sbjct: 506 CGYDVPTPVLSPSSIMLISFQSDENGTCRGFQATVSFIPKAGKK 549
Score = 63.5 bits (153), Expect = 4e-10
Identities = 36/108 (33%), Positives = 57/108 (52%), Gaps = 7/108 (6%)
Query: 166 AQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAV 225
A+G L P Y C W ++ P + + L+F D+E C + +S++
Sbjct: 321 AEGKLHFPESLHLYYESKQRCVWTLLVPEEMHVLLSFSHLDVES---CHHSYLSMY---- 373
Query: 226 SDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTL 273
S + R +GKFCG+++P SI N L ++FVSD + A GF+ +YK L
Sbjct: 374 SLEDRPIGKFCGESLPSSILIGSNSLRLKFVSDATDNAAGFNLTYKAL 421
Score = 46.2 bits (108), Expect = 6e-05
Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 1/99 (1%)
Query: 44 ESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGT 103
E G + S +P Y C W + + LSF+ ++E C D + V +
Sbjct: 439 EEGLIQSLNYPENYSDKANCDWIFQASKHHLIKLSFQSLEIEESGDCTSDYVTVHSDVER 498
Query: 104 SGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF 142
+ + R CG P P+++P + + + +DE RGF
Sbjct: 499 K-KEIARLCGYDVPTPVLSPSSIMLISFQSDENGTCRGF 536
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 92.4 bits (228), Expect = 7e-19
Identities = 77/242 (31%), Positives = 109/242 (45%), Gaps = 28/242 (11%)
Query: 52 GFPNL-YPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAG-SGTSGQRLG 109
GFP+ YP + C W + +SL+FR FDL D + V+ S L
Sbjct: 232 GFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALV 291
Query: 110 RFCGTFRPA-PLVAPGNQ----VTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLE 164
+ CGT+ P+ L +Q +TL T+ G + R +S CGGRL
Sbjct: 292 QLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSS------CGGRLR 345
Query: 165 KAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDL----EPDTYCRYDSVSV 220
KAQGT +P +P YPP I C+W+I P +Q + + F+ F L P C D V +
Sbjct: 346 KAQGTFNSPYYP-GHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEI 404
Query: 221 FNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKE 280
NG K+CG+ ++S N++ V+F SD S T GF A Y +
Sbjct: 405 -NGE---------KYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCP 454
Query: 281 GQ 282
GQ
Sbjct: 455 GQ 456
Score = 61.6 bits (148), Expect = 1e-09
Identities = 38/121 (31%), Positives = 56/121 (46%), Gaps = 8/121 (6%)
Query: 171 TTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSR 230
TTP +P+S YP C W + D V++LTF FDL D V+V+N +
Sbjct: 229 TTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPH 288
Query: 231 RLGKFCGDAVPG---SISSEGNELLVQFVSDLSVTADGFSASYKTLPR-----GTAKEGQ 282
L + CG P + S N LL+ +++ GF A++ LPR G ++ Q
Sbjct: 289 ALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQ 348
Query: 283 G 283
G
Sbjct: 349 G 349
Score = 57.8 bits (138), Expect = 2e-08
Identities = 45/162 (27%), Positives = 71/162 (43%), Gaps = 25/162 (15%)
Query: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHP-----ACR 91
CGG ++ G S +P YPPN +C W I VP Q V + F+ F L L P C
Sbjct: 340 CGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYL-LEPGVPAGTCP 398
Query: 92 YDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRAT 151
D +E+ +G+ ++CG + + N++T+R +D+ GFL Y +
Sbjct: 399 KDYVEI------NGE---KYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDS 449
Query: 152 SGTEHQFCGGRLEKAQG-----TLTTPNWPE-SDYPPGISCS 187
S C G+ G L W + +D+ ++CS
Sbjct: 450 SDP----CPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS 487
>gi|110815798 ovochymase 1 [Homo sapiens]
Length = 1134
Score = 88.2 bits (217), Expect = 1e-17
Identities = 68/237 (28%), Positives = 104/237 (43%), Gaps = 34/237 (14%)
Query: 81 VFDLELHPACRYDALEVFAGSGT----------SGQRLGRFCGTFRPAPLVAPGNQVTLR 130
+ D+E C +D + + + SG G++ R CG P+PL+A ++ +
Sbjct: 332 ILDMEKQVGCDHDYVSLRSSSGVLFNQRSLMEDDGKQNKRVCGKILPSPLLAETSEAMVP 391
Query: 131 MTTDEGTGGRGFLLWYSG----RATSGTEHQFCGG-RLEKAQGTLTTPNWPESDYPPGIS 185
+D G GF L + A SG CG + +GT + +P+ YP
Sbjct: 392 FVSDTEDSGSGFELTVTAVQKSEAGSG-----CGSLAILVEEGTNHSAKYPDL-YPSNTR 445
Query: 186 CSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSIS 245
C W I AP +I LTFE F ++ C YD+V ++ S++ +L K CG SI
Sbjct: 446 CHWFICAPEKHIIKLTFEDFAVKFSPNCIYDAVVIYGD--SEEKHKLAKLCGMLTITSIF 503
Query: 246 SEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKSQP 302
S N ++ F SD GF A + LP + + EP KLPP++ P
Sbjct: 504 SSSNMTVIYFKSDGKNRLQGFKARFTILPSESLNK---------FEP--KLPPQNNP 549
Score = 57.8 bits (138), Expect = 2e-08
Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 1/99 (1%)
Query: 44 ESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGT 103
E G S +P+LYP N C W I PE + L+F F ++ P C YDA+ ++ G
Sbjct: 427 EEGTNHSAKYPDLYPSNTRCHWFICAPEKHIIKLTFEDFAVKFSPNCIYDAVVIY-GDSE 485
Query: 104 SGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF 142
+L + CG + + N + +D +GF
Sbjct: 486 EKHKLAKLCGMLTITSIFSSSNMTVIYFKSDGKNRLQGF 524
Score = 39.3 bits (90), Expect = 0.007
Identities = 43/187 (22%), Positives = 68/187 (36%), Gaps = 29/187 (15%)
Query: 57 YPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVF--------AGSGTSGQRL 108
Y EC W + V + L P C+ L ++ G G+RL
Sbjct: 867 YRGRLECSWVLRVSASSMAKFTIEYLSLLGSPVCQDSVLIIYEERHSKRKTAGGLHGRRL 926
Query: 109 GRFCGTFR-PAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSG---------RATSGTEHQF 158
+ TF P PLV +VT G +L G +S EH
Sbjct: 927 --YSMTFMSPGPLV----RVTFHALVRGAFGISYIVLKVLGPKDSKITRLSQSSNREHLV 980
Query: 159 -CGG-RLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
C L K +G + P + + + C W ++AP + +I L F ++P T+ +
Sbjct: 981 PCEDVLLTKPEGIMQIPR---NSHRTTMGCQWRLVAPLNHIIQLNIINFPMKPTTFVCHG 1037
Query: 217 SVSVFNG 223
+ V+ G
Sbjct: 1038 HLRVYEG 1044
>gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [Homo
sapiens]
Length = 380
Score = 85.1 bits (209), Expect = 1e-16
Identities = 76/277 (27%), Positives = 118/277 (42%), Gaps = 61/277 (22%)
Query: 46 GYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSG 105
G + S G+P+ YP + E W ITVP+G + L F F+LE C YD ++V T
Sbjct: 29 GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETED 84
Query: 106 QRLGRFCG--------TFRPAPLVAPGNQVTLRMTTDEGTGGR--GFLLWYSGRATSGTE 155
Q L FCG T +++PG+ +++ +D R GF Y +
Sbjct: 85 QVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
Query: 156 -------------HQFCGG------------------RLE-------KAQGTLTTPNWPE 177
H + GG R+E + G +T+P++P
Sbjct: 145 EREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP- 203
Query: 178 SDYPPGISCSWHIIAPPDQVIALTFEK-FDLE--PDTYCRYDSVSVFNGAVSDDSRRLGK 234
+ YP C + I ++ L FE FD+E P+ C YD + + G + LG
Sbjct: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG-----PKVLGP 258
Query: 235 FCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
FCG+ P IS++ + +L+ F SD S G+ SY+
Sbjct: 259 FCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR 295
Score = 68.6 bits (166), Expect = 1e-11
Identities = 43/127 (33%), Positives = 64/127 (50%), Gaps = 8/127 (6%)
Query: 45 SGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFR-VFDLELHP--ACRYDALEVFAGS 101
+G + S FPN YP + EC++TI + EG V+L F +FD+E HP C YD +++ G
Sbjct: 194 TGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGP 253
Query: 102 GTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQ-FCG 160
+ LG FCG P P+ + V + +D RG+ L Y E Q
Sbjct: 254 ----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVH 309
Query: 161 GRLEKAQ 167
G++E +Q
Sbjct: 310 GKIEPSQ 316
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/123 (30%), Positives = 53/123 (43%), Gaps = 16/123 (13%)
Query: 168 GTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSD 227
G + +P +P+S YP +W+I P I L F F+LE C YD V V
Sbjct: 29 GQIQSPGYPDS-YPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVK-----VET 82
Query: 228 DSRRLGKFCG------DAVPGS--ISSEGNELLVQFVSDLS--VTADGFSASYKTLPRGT 277
+ + L FCG + PG + S G+ + + F SD S GF A Y +
Sbjct: 83 EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDE 142
Query: 278 AKE 280
KE
Sbjct: 143 CKE 145
>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
precursor [Homo sapiens]
Length = 728
Score = 85.1 bits (209), Expect = 1e-16
Identities = 76/277 (27%), Positives = 118/277 (42%), Gaps = 61/277 (22%)
Query: 46 GYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSG 105
G + S G+P+ YP + E W ITVP+G + L F F+LE C YD ++V T
Sbjct: 29 GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETED 84
Query: 106 QRLGRFCG--------TFRPAPLVAPGNQVTLRMTTDEGTGGR--GFLLWYSGRATSGTE 155
Q L FCG T +++PG+ +++ +D R GF Y +
Sbjct: 85 QVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
Query: 156 -------------HQFCGG------------------RLE-------KAQGTLTTPNWPE 177
H + GG R+E + G +T+P++P
Sbjct: 145 EREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP- 203
Query: 178 SDYPPGISCSWHIIAPPDQVIALTFEK-FDLE--PDTYCRYDSVSVFNGAVSDDSRRLGK 234
+ YP C + I ++ L FE FD+E P+ C YD + + G + LG
Sbjct: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG-----PKVLGP 258
Query: 235 FCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
FCG+ P IS++ + +L+ F SD S G+ SY+
Sbjct: 259 FCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR 295
Score = 68.6 bits (166), Expect = 1e-11
Identities = 43/127 (33%), Positives = 64/127 (50%), Gaps = 8/127 (6%)
Query: 45 SGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFR-VFDLELHP--ACRYDALEVFAGS 101
+G + S FPN YP + EC++TI + EG V+L F +FD+E HP C YD +++ G
Sbjct: 194 TGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGP 253
Query: 102 GTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQ-FCG 160
+ LG FCG P P+ + V + +D RG+ L Y E Q
Sbjct: 254 ----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVH 309
Query: 161 GRLEKAQ 167
G++E +Q
Sbjct: 310 GKIEPSQ 316
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/123 (30%), Positives = 53/123 (43%), Gaps = 16/123 (13%)
Query: 168 GTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSD 227
G + +P +P+S YP +W+I P I L F F+LE C YD V V
Sbjct: 29 GQIQSPGYPDS-YPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVK-----VET 82
Query: 228 DSRRLGKFCG------DAVPGS--ISSEGNELLVQFVSDLS--VTADGFSASYKTLPRGT 277
+ + L FCG + PG + S G+ + + F SD S GF A Y +
Sbjct: 83 EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDE 142
Query: 278 AKE 280
KE
Sbjct: 143 CKE 145
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,659,184
Number of Sequences: 37866
Number of extensions: 1183143
Number of successful extensions: 6768
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 109
Number of HSP's that attempted gapping in prelim test: 5433
Number of HSP's gapped (non-prelim): 979
length of query: 449
length of database: 18,247,518
effective HSP length: 106
effective length of query: 343
effective length of database: 14,233,722
effective search space: 4882166646
effective search space used: 4882166646
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.