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Search of human proteins with 157426829
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157426829 leucine rich repeat and Ig domain containing 3
[Homo sapiens]
(592 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 1178 0.0
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 661 0.0
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 625 e-179
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 444 e-124
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 185 9e-47
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 185 9e-47
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 164 2e-40
gi|51317373 netrin-G1 ligand [Homo sapiens] 160 4e-39
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 159 7e-39
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 159 9e-39
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 157 2e-38
gi|188528675 slit homolog 1 [Homo sapiens] 156 4e-38
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 155 1e-37
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 154 3e-37
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 154 3e-37
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 154 3e-37
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 153 4e-37
gi|13375646 leucine rich repeat and fibronectin type III domain ... 150 2e-36
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 149 9e-36
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 149 9e-36
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 145 1e-34
gi|225579152 insulin-like growth factor binding protein, acid la... 145 1e-34
gi|4826772 insulin-like growth factor binding protein, acid labi... 145 1e-34
gi|149773484 leucine rich repeat and fibronectin type III domain... 145 1e-34
gi|4759146 slit homolog 2 [Homo sapiens] 144 3e-34
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 144 3e-34
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 144 3e-34
gi|12007646 nyctalopin precursor [Homo sapiens] 143 4e-34
gi|31542244 leucine rich repeat and fibronectin type III domain ... 142 9e-34
gi|55741571 leucine rich repeat and fibronectin type III domain ... 139 7e-33
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 1178 bits (3047), Expect = 0.0
Identities = 592/592 (100%), Positives = 592/592 (100%)
Query: 1 MTCWLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLE 60
MTCWLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLE
Sbjct: 1 MTCWLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLE 60
Query: 61 LSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPG 120
LSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPG
Sbjct: 61 LSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPG 120
Query: 121 VFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELT 180
VFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELT
Sbjct: 121 VFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELT 180
Query: 181 LERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAA 240
LERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAA
Sbjct: 181 LERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAA 240
Query: 241 GSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELH 300
GSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELH
Sbjct: 241 GSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELH 300
Query: 301 LAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL 360
LAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL
Sbjct: 301 LAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL 360
Query: 361 LWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTAT 420
LWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTAT
Sbjct: 361 LWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTAT 420
Query: 421 AGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTC 480
AGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTC
Sbjct: 421 AGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTC 480
Query: 481 VASNAGGNDTYFATLTVRPEPAANRTPGEAHNETLAALRAPLDLTTILVSTAMGCITFLG 540
VASNAGGNDTYFATLTVRPEPAANRTPGEAHNETLAALRAPLDLTTILVSTAMGCITFLG
Sbjct: 481 VASNAGGNDTYFATLTVRPEPAANRTPGEAHNETLAALRAPLDLTTILVSTAMGCITFLG 540
Query: 541 VVLFCFVLLFVWSRGRGQHKNNFSVEYSFRKVDGPAAAAGQGGARKFNMKMI 592
VVLFCFVLLFVWSRGRGQHKNNFSVEYSFRKVDGPAAAAGQGGARKFNMKMI
Sbjct: 541 VVLFCFVLLFVWSRGRGQHKNNFSVEYSFRKVDGPAAAAGQGGARKFNMKMI 592
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 661 bits (1705), Expect = 0.0
Identities = 339/603 (56%), Positives = 439/603 (72%), Gaps = 13/603 (2%)
Query: 1 MTCWLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLE 60
++CW L L ++L+ GCPARCEC+ Q ++V+C RRRL A+P+GIP ET++L+
Sbjct: 6 ISCWQPFLGLAVVLIFMGSTI--GCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILD 63
Query: 61 LSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPG 120
LS+NR++ +NP + + P LEE+DLS+N IA+VEPGAF NL LR LRL+GN+LKL+P G
Sbjct: 64 LSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLG 123
Query: 121 VFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELT 180
VFT L NLT LD+SENK+VILLDY FQDLH+L+ LEVGDNDLV++S RAF+GLL+LE+LT
Sbjct: 124 VFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLT 183
Query: 181 LERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAA 240
LE+CNLTA+ E+L HLRSL +L L+HL I ++ F+RL L HLEID WPLL+ + A
Sbjct: 184 LEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPA 243
Query: 241 GSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELH 300
SL GLNLTSLSVT+TN++ VP A +H +LT LNLS+NPIST+ G F DL+RL+ELH
Sbjct: 244 NSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELH 303
Query: 301 LAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL 360
+ GA L +EP +F GLR +R+LN+S NLL TLEE+ F S LE L ++ NPLACDCRL
Sbjct: 304 IVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRL 363
Query: 361 LWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTAT 420
LWI+QR+ TL F G+ P CA P +R + ++ + L YF C+KPKIRE++LQ +
Sbjct: 364 LWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVD 423
Query: 421 AGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTC 480
G+ V+ C A+G+P P ++WVTP+ R +T S GRA VL GTLEI+ A+ QDSG Y C
Sbjct: 424 EGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVC 483
Query: 481 VASNAGGNDTYFATLTVRPEPA-----ANRTP--GEAHNETLA----ALRAPLDLTTILV 529
+ASNA GNDT+ A+LTV+ + ANRTP N+T++ A LDL TILV
Sbjct: 484 IASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKTILV 543
Query: 530 STAMGCITFLGVVLFCFVLLFVWSRGRGQHKNNFSVEYSFRKVDGPAAAAGQGGARKFNM 589
STAMGC TFLGVVLFCF+LLFVWSRG+G+HKN+ +EY RK +G G R+FNM
Sbjct: 544 STAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNM 603
Query: 590 KMI 592
KMI
Sbjct: 604 KMI 606
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 625 bits (1612), Expect = e-179
Identities = 326/605 (53%), Positives = 420/605 (69%), Gaps = 17/605 (2%)
Query: 1 MTCWLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLE 60
+ CW +L L +L A GCP RCEC+ Q RAV C R+R AVP+GIP ETRLL+
Sbjct: 20 LACWQPILLL--VLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLD 77
Query: 61 LSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPG 120
L +NRI+ LN + A+ P LEEL+L+EN ++ VEPGAF NL LR L LR N+LKLIP G
Sbjct: 78 LGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLG 137
Query: 121 VFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELT 180
VFT L NLT LD+SENK+VILLDY FQDL++L+ LEVGDNDLV++S RAF+GL +LE+LT
Sbjct: 138 VFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLT 197
Query: 181 LERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAA 240
LE+CNLT++ E+L HL L LRLRHL I ++ D +F+RL L LEI +WP L+ +
Sbjct: 198 LEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTP 257
Query: 241 GSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELH 300
L GLNLTSLS+TH N+TAVP A+RH +L LNLS+NPIST+ +L+RL+E+
Sbjct: 258 NCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQ 317
Query: 301 LAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL 360
L G LAVVEP AF GL +R+LN+S N L+TLEES FHSV LETL +D NPLACDCRL
Sbjct: 318 LVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRL 377
Query: 361 LWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTAT 420
LW+ +RR LNF+ + P CATP V+G ++ PD +L YF CR+ +IR+R+ Q+V
Sbjct: 378 LWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVD 437
Query: 421 AGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTC 480
G V+F+CRA+G+P P + W++P+ V+A S GR V P GTLE++ A+ QD+GTY C
Sbjct: 438 EGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLC 497
Query: 481 VASNAGGNDTYFATLTVRP-----EPAANRT-------PGEAH-NETLAALRAPLDLTTI 527
+A+NAGGND+ A L VR N+T PGE N T A + P D+ T+
Sbjct: 498 IAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTL 557
Query: 528 LVSTAMGCITFLGVVLFCFVLLFVWSRGRGQHKNNFSVEYSFRKVDGPAAAAGQGGARKF 587
+++T MG I+FLGVVLFC VLLF+WSRG+G K+N +EY RK D A + RKF
Sbjct: 558 IIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSD--AGISSADAPRKF 615
Query: 588 NMKMI 592
NMKMI
Sbjct: 616 NMKMI 620
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 444 bits (1141), Expect = e-124
Identities = 258/576 (44%), Positives = 348/576 (60%), Gaps = 12/576 (2%)
Query: 11 PLLLLPAAPPPAGG-CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCL 69
PLL L P +GG CPA C+CT Q +AV C R+L AVP G+P +T LL+LS NR+ L
Sbjct: 16 PLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGL 75
Query: 70 NPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLT 129
G L+ L L+ELDLS N ++ +EPGAF L L LRL+GN+L+++ PGVF+ L LT
Sbjct: 76 QQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALT 135
Query: 130 LLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTAL 189
LLDL N++V+ LD F +L SL++LEVGDN LVFV+ AFAGL L LTLERCNL+ +
Sbjct: 136 LLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTV 195
Query: 190 SGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLT 249
G +L L +L ALRLR L I L R L L LEI WP LE + GSL GLNL+
Sbjct: 196 PGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLS 255
Query: 250 SLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVV 309
SL++T N+++VP AL H + L L+LS NPIS +P LVRL+EL L+GA L +
Sbjct: 256 SLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSI 315
Query: 310 EPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKT 369
AF GL LL++++N L TLEE+ F S + L TLR+ GNPL CDCRLLW+++ R+
Sbjct: 316 AAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRH 375
Query: 370 LNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLC 429
L+F PACA P V+G +L+ D + +F C+ IR+ + V A G F C
Sbjct: 376 LDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSC 435
Query: 430 RAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGND 489
+G+PAPTV+W+ P AGR RVL GTLEI+ + +D G Y CV SN GND
Sbjct: 436 SGDGDPAPTVSWMRP--HGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGND 493
Query: 490 ---TYFATLTVRPEPAANRTPGEAHNETLAALRAP--LDLTTILVSTAMGCITFLGVVLF 544
T+ + V P P N T+ + P LD + + A+G + FL V
Sbjct: 494 SLRTWLEVIQVEPPNGTLSDP----NITVPGIPGPFFLDSRGVAMVLAVGFLPFLTSVTL 549
Query: 545 CFVLLFVWSRGRGQHKNNFSVEYSFRKVDGPAAAAG 580
CF L+ +WS+G+G+ K++ + ++ + G + G
Sbjct: 550 CFGLIALWSKGKGRVKHHMTFDFVAPRPSGDKNSGG 585
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 185 bits (470), Expect = 9e-47
Identities = 151/513 (29%), Positives = 230/513 (44%), Gaps = 67/513 (13%)
Query: 25 CPARCECTV-----------QTRAVACTRRRLTAVPDGIPAETRLL-------------- 59
CP +C C + + V C LTAVP +PA T+ L
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 60 ----------ELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRL 109
+LS+N D ALP L L L EN + +E +FA L L+ L L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 110 RGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRA 169
NQL I P F+ L NL L L+ N L + F+ L +L L +G N + +
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 170 FAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI 229
F L L L L NL +S +L L+SL +L +A + + ++PGL L++
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
Query: 230 DNWPLLEEVAAGSLRG-LNLTSLSVTH-TNITAVPAAALRHQAHLTCLNLSHNPISTVPR 287
+ P L+ V G L+L L + + + ++ AL + LT L++++NP
Sbjct: 269 NKNP-LQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP------ 321
Query: 288 GSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETL 347
L+ + P+AF L Q+ L L+NN LS L + T S+ L+ +
Sbjct: 322 -----------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
Query: 348 RVDGNPLACDCRLLWIVQRRKTLNF-DGRLPACATPAEVRGDALRNLPDSVLFEYFVCRK 406
+ GNP+ CDC + W + F + + CA P +++ +R +P + ++ +
Sbjct: 365 GLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCL--- 421
Query: 407 PKIRERRL-QRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRA-RVLPGGT 464
P I R + +GE + CRA EP P + WVTP +T AGR RV P GT
Sbjct: 422 PLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGT 481
Query: 465 LEIQDARPQDSGTYTCVASNAGGNDTYFATLTV 497
LE++ +++G YTCVA N G DT ++ V
Sbjct: 482 LELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 185 bits (470), Expect = 9e-47
Identities = 151/513 (29%), Positives = 230/513 (44%), Gaps = 67/513 (13%)
Query: 25 CPARCECTV-----------QTRAVACTRRRLTAVPDGIPAETRLL-------------- 59
CP +C C + + V C LTAVP +PA T+ L
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 60 ----------ELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRL 109
+LS+N D ALP L L L EN + +E +FA L L+ L L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 110 RGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRA 169
NQL I P F+ L NL L L+ N L + F+ L +L L +G N + +
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 170 FAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI 229
F L L L L NL +S +L L+SL +L +A + + ++PGL L++
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
Query: 230 DNWPLLEEVAAGSLRG-LNLTSLSVTH-TNITAVPAAALRHQAHLTCLNLSHNPISTVPR 287
+ P L+ V G L+L L + + + ++ AL + LT L++++NP
Sbjct: 269 NKNP-LQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP------ 321
Query: 288 GSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETL 347
L+ + P+AF L Q+ L L+NN LS L + T S+ L+ +
Sbjct: 322 -----------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
Query: 348 RVDGNPLACDCRLLWIVQRRKTLNF-DGRLPACATPAEVRGDALRNLPDSVLFEYFVCRK 406
+ GNP+ CDC + W + F + + CA P +++ +R +P + ++ +
Sbjct: 365 GLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCL--- 421
Query: 407 PKIRERRL-QRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRA-RVLPGGT 464
P I R + +GE + CRA EP P + WVTP +T AGR RV P GT
Sbjct: 422 PLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGT 481
Query: 465 LEIQDARPQDSGTYTCVASNAGGNDTYFATLTV 497
LE++ +++G YTCVA N G DT ++ V
Sbjct: 482 LELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 164 bits (415), Expect = 2e-40
Identities = 142/530 (26%), Positives = 220/530 (41%), Gaps = 66/530 (12%)
Query: 7 VLSLPLLLLPAAPPPAGGCPARCECTV-----------QTRAVACTRRRLTAVPDGIPAE 55
VL L + L + CP C C + + V C RLT +P + ++
Sbjct: 14 VLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSD 73
Query: 56 TRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQL- 114
T++L L N I +L L L ELD S+N +++ ANL +L L L NQ+
Sbjct: 74 TQVLLLQSNNI-AKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQIT 132
Query: 115 -----------------------KLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHS 151
I F L NL L L+ NKL ++ F +
Sbjct: 133 EMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPN 192
Query: 152 LRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIA 211
L L +G+N ++ + F L L L L LT + G +L L SL +L +
Sbjct: 193 LEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLV 252
Query: 212 SLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRG-LNLTSLSVTHT-NITAVPAAALRHQ 269
+ +++P L L+++ P + ++ G + L L L + + + +V AL +
Sbjct: 253 KVPQLALQKVPNLKFLDLNKNP-IHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNL 311
Query: 270 AHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNL 329
LT L ++NP L+ + AF + + L L+NN
Sbjct: 312 PELTKLEATNNP-----------------------KLSYIHRLAFRSVPALESLMLNNNA 348
Query: 330 LSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPA-CATPAEVRGD 388
L+ + + T S+ L + + NPL CDC + WI + + F L CA P E +G
Sbjct: 349 LNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGH 408
Query: 389 ALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRP 448
++ + E C + R+ G V CRA EP P + WVTP
Sbjct: 409 QVKEVLIQDSSEQ--CLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNK 466
Query: 449 VTA-TSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTV 497
+T T + + ++ GTLEI + + +DSG YTCVA N G DT AT+ V
Sbjct: 467 ITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKV 516
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 160 bits (404), Expect = 4e-39
Identities = 128/407 (31%), Positives = 198/407 (48%), Gaps = 19/407 (4%)
Query: 105 RVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVF 164
+V+ +R N L+ +P G+ T N LL+L EN++ I+ +F+ L L L++ N +
Sbjct: 59 KVICVRKN-LREVPDGIST---NTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRT 114
Query: 165 VSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGL 224
+ AF GL L L L LT + + +L L L LR+ I S+ F R+P L
Sbjct: 115 IEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSL 174
Query: 225 LHLEIDNWPLLEEVAAGSLRGL-NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPIS 283
L++ L ++ G+ GL NL L++ N+ +P L L L+LS N +S
Sbjct: 175 RRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLS 232
Query: 284 TVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNT 343
+ GSF+ L+ L++L + + + V+E AF L+ + +NL++N L+ L F ++
Sbjct: 233 AIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHH 292
Query: 344 LETLRVDGNPLACDCRLLWIVQRRKTL--NFDGRLPACATPAEVRGDALRNLPDSVLFEY 401
LE + + NP C+C +LW+ K + + C TP ++G + L + Y
Sbjct: 293 LERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQN----Y 348
Query: 402 FVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVT-ATSAGRARVL 460
F C P I E + T G CRA +V+W+TP +T R VL
Sbjct: 349 FTCYAPVIVEPPAD-LNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVL 406
Query: 461 PGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTP 507
GTL + QD+G YTC+ SN+ GN T ATL V AA TP
Sbjct: 407 SDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNV---TAATTTP 450
Score = 132 bits (333), Expect = 7e-31
Identities = 99/283 (34%), Positives = 138/283 (48%), Gaps = 13/283 (4%)
Query: 5 LCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRN 64
L VL LL+ A A CP+ C C+ Q V C R+ L VPDGI TRLL L N
Sbjct: 27 LVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHEN 86
Query: 65 RIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTR 124
+I+ + L LE L LS N I +E GAF L L L L N+L IP G F
Sbjct: 87 QIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVY 146
Query: 125 LDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGD-NDLVFVSRRAFAGLLALEELTLER 183
L L L L N + + Y F + SLRRL++G+ L ++S AF GL L L L
Sbjct: 147 LSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAM 206
Query: 184 CNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLE-----IDNWPLLEEV 238
CNL + +L L L L L ++++ +F+ GL+HL+ ++E
Sbjct: 207 CNLREI--PNLTPLIKLDELDLSGNHLSAIRPGSFQ---GLMHLQKLWMIQSQIQVIERN 261
Query: 239 AAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNP 281
A +L+ +L +++ H N+T +P HL ++L HNP
Sbjct: 262 AFDNLQ--SLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNP 302
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 159 bits (402), Expect = 7e-39
Identities = 145/483 (30%), Positives = 211/483 (43%), Gaps = 86/483 (17%)
Query: 20 PPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPA 79
PPA CP C C+ Q V CTRR DLA +PA
Sbjct: 52 PPATSCPVACSCSNQASRVICTRR-----------------------------DLAEVPA 82
Query: 80 LEELDLSENAIAHVEPGAFANLP-RLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKL 138
++P R L L+ N +++I F L +L +L LS+N +
Sbjct: 83 --------------------SIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLV 122
Query: 139 VILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLR 198
R++EVG AF GL +L L L LT + ++ +L
Sbjct: 123 --------------RKIEVG----------AFNGLPSLNTLELFDNRLTTVPTQAFEYLS 158
Query: 199 SLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGL-NLTSLSVTHTN 257
L L LR+ I S+ F R+P L L++ LE ++ + GL NL L++ N
Sbjct: 159 KLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCN 218
Query: 258 ITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGL 317
+ +P L L L LS N + + GSF+ L LR+L L A +A +E AF L
Sbjct: 219 LKDIPN--LTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDL 276
Query: 318 RQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIV-QRRKTLNFDGRL 376
+ + LNLS+N L +L F ++ LE + ++ NP C+C +LW+ ++T+ +
Sbjct: 277 KSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTC 336
Query: 377 PA-CATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEP 435
A C PA ++G + L S +F C P I E + T G CR G
Sbjct: 337 CARCHAPAGLKGRYIGELDQS----HFTCYAPVIVEPPTD-LNVTEGMAAELKCRT-GTS 390
Query: 436 APTVAWVTPQHRPVTATS-AGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFAT 494
+V W+TP +T S R VL GTL + QD+G YTC+ +N+ GN T AT
Sbjct: 391 MTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASAT 450
Query: 495 LTV 497
L V
Sbjct: 451 LNV 453
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 159 bits (401), Expect = 9e-39
Identities = 139/449 (30%), Positives = 197/449 (43%), Gaps = 65/449 (14%)
Query: 4 WLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPA--------- 54
WL SL LL PA P CP C+C VQ V C+ L VP IP
Sbjct: 6 WLLWTSLLLLARPAQP-----CPMGCDCFVQE--VFCSDEELATVPLDIPPYTKNIIFVE 58
Query: 55 ------ETRLLELSRNRIRCL---------NPGDLAALPALEELD--------------- 84
ETR + N + + P LP LE+L+
Sbjct: 59 TSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFS 118
Query: 85 ---------LSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSE 135
L+ N + + G F +L L L L+GNQL+ +P +F L +L L+L++
Sbjct: 119 NLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQ 178
Query: 136 NKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLG 195
N L L + F L SL+ L++ +N L + + F L +L+EL L+ N++ L +
Sbjct: 179 NLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFS 238
Query: 196 HLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-LTSLSVT 254
L L L L+ AI L F L L L + W +L + AG L LS+T
Sbjct: 239 QLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQ-WNMLRVLPAGLFAHTPCLVGLSLT 297
Query: 255 HTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAF 314
H + V H ++L L LS+N I+ +P G FRDL L +L+L L + P F
Sbjct: 298 HNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALF 357
Query: 315 LGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLL----WIVQ-RRKT 369
L ++ LL+LS N L+TL E F + L L + GNP CDC L W+ Q +
Sbjct: 358 QNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRL 417
Query: 370 LNFDGRLPACATPAEVRGDALRNLPDSVL 398
LN CA PA ++G + L + L
Sbjct: 418 LNIQ---TYCAGPAYLKGQVVPALNEKQL 443
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 157 bits (398), Expect = 2e-38
Identities = 144/490 (29%), Positives = 196/490 (40%), Gaps = 93/490 (18%)
Query: 17 AAPPPAG--GCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDL 74
AA AG CP+ C C+ Q V CTRR L+ VP GIP+ TR L L N I+ +
Sbjct: 36 AAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTF 95
Query: 75 AALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLS 134
L LE L L N+I +E GAF L L L L N L +IP G F L L L L
Sbjct: 96 RHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLR 155
Query: 135 ENKLVILLDYTFQDLHSLRRLEVGD-NDLVFVSRRAFAGLLALEELTLERCNLTALSGES 193
N + + Y F + SL RL++G+ L ++S AF GL L+ L L CN+ +
Sbjct: 156 NNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDM---- 211
Query: 194 LGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI--DNWPLLEEVAAGSLRGL-NLTS 250
N L GL LE+ +++P E+ GS GL +L
Sbjct: 212 ----------------------PNLTPLVGLEELEMSGNHFP---EIRPGSFHGLSSLKK 246
Query: 251 LSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVE 310
L V ++ ++ + A A L LNL+HN +S++P F L L ELHL
Sbjct: 247 LWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHL--------- 297
Query: 311 PQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIV--QRRK 368
NP CDC +LW+ R
Sbjct: 298 ---------------------------------------HHNPWNCDCDILWLAWWLREY 318
Query: 369 TLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFL 428
C P +RG L + + F C P I + + + + G
Sbjct: 319 IPTNSTCCGRCHAPMHMRGRYLVEVDQA----SFQCSAPFIMDAP-RDLNISEGRMAELK 373
Query: 429 CRAEGEPAPTVAWVTPQHRPVT-ATSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGG 487
CR P +V W+ P ++ A+ R VL GTL D+G YTC+ +N G
Sbjct: 374 CRT--PPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAG 431
Query: 488 NDTYFATLTV 497
N A L V
Sbjct: 432 NSNASAYLNV 441
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 156 bits (395), Expect = 4e-38
Identities = 131/412 (31%), Positives = 190/412 (46%), Gaps = 36/412 (8%)
Query: 25 CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNP-GDLAALPALEEL 83
CP +C C + V C+ +LT +P+ IP T L L+ N I L G L L+++
Sbjct: 513 CPHKCRC--EANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKI 570
Query: 84 DLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLD 143
+LS N ++ +E GAF + L L NQL+ I G+F LD L L L N++ + +
Sbjct: 571 NLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN 630
Query: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLE------RCNLTALSGES---- 193
+F L ++R L + DN + VS AF L +L L L C L L G
Sbjct: 631 DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRK 690
Query: 194 --LGHLRSLGALRLRHLAIASLEDQNFRRLPGLLH---LEIDNWP----LLEEVAAGS-- 242
G+ R LR + + + +FR G L P L+ V S
Sbjct: 691 IVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNK 750
Query: 243 -LRGL------NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVR 295
LR L N+T L + T VP L +L ++LS+N IS++ SF ++ +
Sbjct: 751 HLRALPKGIPKNVTELYLDGNQFTLVPGQ-LSTFKYLQLVDLSNNKISSLSNSSFTNMSQ 809
Query: 296 LRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA 355
L L L+ L + P AF GLR +RLL+L N +STL+E F V +L L + NPL
Sbjct: 810 LTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLY 869
Query: 356 CDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKP 407
CDC L W+ KT + + CA P ++ G L P + F C+ P
Sbjct: 870 CDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTP----AKKFECQGP 917
Score = 150 bits (379), Expect = 3e-36
Identities = 125/461 (27%), Positives = 203/461 (44%), Gaps = 80/461 (17%)
Query: 15 LPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDL 74
+P +G CPA C C+ V C + LTA+P +P + L N I+ + PG
Sbjct: 272 VPTCTLSSGSCPAMCTCS--NGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAF 329
Query: 75 AALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLS 134
+ L +DLS N IA + P AF L L L L GN++ +P GVF L L LL L+
Sbjct: 330 SPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLN 389
Query: 135 ENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLER------CNLTA 188
NK+ + FQDL +L L + DN + +++ F L A++ L L + CNL
Sbjct: 390 ANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKW 449
Query: 189 LSG-------ESLGHLRSLGALRLRHLAIASLEDQNFR---------------------- 219
L+ E+ G R RL + I ++ + FR
Sbjct: 450 LADFLRTNPIETSG-ARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECN 508
Query: 220 ----------------------------RLP-GLLHLEIDNWPLLEEVAAGSLRGL-NLT 249
R+P L ++N + A G + L +L
Sbjct: 509 SDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLK 568
Query: 250 SLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVV 309
+++++ ++ + A A ++ L+L+ N + ++ G FR L LR L L ++ +
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 628
Query: 310 EPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWI---VQR 366
+F GLR +RLL+L +N ++T+ F ++ +L TL + NP C+C+L W+ +++
Sbjct: 629 HNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRK 688
Query: 367 RKTLNFDGRLPACATPAEVRGDALRNLP-DSVLFEYFVCRK 406
RK + + P C P D LR +P V F F C +
Sbjct: 689 RKIVTGN---PRCQNP-----DFLRQIPLQDVAFPDFRCEE 721
Score = 147 bits (371), Expect = 3e-35
Identities = 124/442 (28%), Positives = 180/442 (40%), Gaps = 84/442 (19%)
Query: 22 AGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALE 81
A CPA C CT T V C L A+P IP T LEL+ N I ++ D A L L
Sbjct: 31 ASACPALCTCTGTT--VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLR 88
Query: 82 ELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVIL 141
L L EN I VE GAF ++ L LRL NQL ++P +F L+ LDLSEN + +
Sbjct: 89 VLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAI 148
Query: 142 LDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSL- 200
F+ L+ L++ N + + AF L LE LTL N+T + S H+ L
Sbjct: 149 PRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLR 208
Query: 201 -----------------------------------GALRLRHLAIASLEDQNFR------ 219
G LR L +A ++ F
Sbjct: 209 TFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGE 268
Query: 220 --RLPGLLHLEIDNWPLLEEVAAG--SLRGLNLTS-----------LSVTHTNITAVPAA 264
R+P L + P + + G RG LT+ + + I ++P
Sbjct: 269 AGRVP-TCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPG 327
Query: 265 ALRHQAHLTCLNLSHNPISTV------------------------PRGSFRDLVRLRELH 300
A L ++LS+N I+ + PRG F L L+ L
Sbjct: 328 AFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLL 387
Query: 301 LAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL 360
L + + P AF L+ + LL+L +N + +L + TF S+ ++TL + NP CDC L
Sbjct: 388 LNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNL 447
Query: 361 LWIVQRRKTLNFDGRLPACATP 382
W+ +T + CA+P
Sbjct: 448 KWLADFLRTNPIETSGARCASP 469
Score = 83.2 bits (204), Expect = 6e-16
Identities = 59/211 (27%), Positives = 93/211 (44%), Gaps = 24/211 (11%)
Query: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
E L L N+T + L+ L L+L I ++E F D+ LE
Sbjct: 64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAF-----------DDMKELE 112
Query: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296
L + + +P ++ L+ L+LS N I +PR +FR L
Sbjct: 113 R-------------LRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDL 159
Query: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLAC 356
+ L L ++ +E AF LR + +L L+NN ++T+ S+F+ + L T R+ N L C
Sbjct: 160 KNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFC 219
Query: 357 DCRLLWIVQRRKTLNFDGRLPACATPAEVRG 387
DC L W+ Q + G C+ PA +RG
Sbjct: 220 DCHLAWLSQWLRQRPTIGLFTQCSGPASLRG 250
Score = 81.3 bits (199), Expect = 2e-15
Identities = 52/142 (36%), Positives = 70/142 (49%), Gaps = 3/142 (2%)
Query: 21 PAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPAL 80
P CP C C V C+ + L A+P GIP L L N+ L PG L+ L
Sbjct: 730 PRPQCPQECACL--DTVVRCSNKHLRALPKGIPKNVTELYLDGNQFT-LVPGQLSTFKYL 786
Query: 81 EELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVI 140
+ +DLS N I+ + +F N+ +L L L N L+ IPP F L +L LL L N +
Sbjct: 787 QLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIST 846
Query: 141 LLDYTFQDLHSLRRLEVGDNDL 162
L + F D+ SL L +G N L
Sbjct: 847 LQEGIFADVTSLSHLAIGANPL 868
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 155 bits (392), Expect = 1e-37
Identities = 172/610 (28%), Positives = 263/610 (43%), Gaps = 109/610 (17%)
Query: 5 LCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTA-----VPDGIPAETRLL 59
L + LLLLPAA AG CPA C C + + C+RR+L A + +P +T +L
Sbjct: 25 LFIAQTALLLLPAAG--AGLCPAPCSCRIPL--LDCSRRKLPAPSWRALSGLLPPDTAIL 80
Query: 60 ELSRNRIRC---------------------------------------------LNPGDL 74
+ S NR+ +N L
Sbjct: 81 DFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQAL 140
Query: 75 AALPALEELDLSENAIAHV-----------------------EPGAFANLPR-LRVLRLR 110
PALE LDLS N I+ + E G F NL L V++L
Sbjct: 141 QFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLN 200
Query: 111 GNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAF 170
N++ +IPP +F +L +L L+L N++ I+ TFQ L SLR L++ N + + AF
Sbjct: 201 RNRMSMIPPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAF 259
Query: 171 AGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEID 230
GL +EEL LE NLT ++ L LR L L + AI + + L L++
Sbjct: 260 FGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDL- 318
Query: 231 NWPLLEEVAAGSLRGLNLTS-LSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGS 289
++ L + + GL+L L++ +T + R ++L L+L +N IS +
Sbjct: 319 SYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDA 378
Query: 290 ---FRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLET 346
F L L +L L G + + +AF+GL + L+L+NN + +++E+ F S L+
Sbjct: 379 SEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF-SQTHLKE 437
Query: 347 LRVDGNPLACDCRLLWIVQRRKTLNFDGRL-PACATPAEVRGDALRNLPDSVLFEYFVC- 404
L ++ + L CDC L W++Q NF + +CA P + G ++ N V + FVC
Sbjct: 438 LILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILN----VDLKDFVCD 493
Query: 405 --RKPKIRERRLQRVTATAGEDVRFLCRA---EGEPAPTVAW---------VTPQHRPVT 450
KP+IR + + A G +V C A P TV W V ++
Sbjct: 494 DFLKPQIRTHP-ETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSEILYDVDTENFVRY 551
Query: 451 ATSAGRARVLPGGTLEIQDARPQDSGTYTCVASN-AGGNDTYFATLTVRPEPAANRTPGE 509
AG A L + + D G Y C+ +N G N + A LTV P+ +TP +
Sbjct: 552 WQQAGEALEYT-SILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMD 610
Query: 510 AHNETLAALR 519
T A R
Sbjct: 611 LTIRTGAMAR 620
Score = 48.5 bits (114), Expect = 2e-05
Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 417 VTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLP-GGTLEIQDARPQDS 475
+T G R C AEG PAP ++W A R V+P I + + +D
Sbjct: 611 LTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDM 670
Query: 476 GTYTCVASNAGGNDTYFATLTVRPEPA 502
G Y+C+A N G + A+LTV P+
Sbjct: 671 GIYSCMAQNTAGGLSANASLTVLETPS 697
Score = 43.5 bits (101), Expect = 5e-04
Identities = 32/102 (31%), Positives = 42/102 (41%), Gaps = 2/102 (1%)
Query: 412 RRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDAR 471
R L+ T T GE C A G PAP + W T P+ T L I DA
Sbjct: 700 RPLEDKTVTRGETAVLQCIAGGSPAPRLNW-TKDDGPLLVTER-HFFAAANQLLIIVDAG 757
Query: 472 PQDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTPGEAHNE 513
+D+G YTC+ SN G + L V P + + +E
Sbjct: 758 LEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHE 799
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 154 bits (388), Expect = 3e-37
Identities = 130/545 (23%), Positives = 211/545 (38%), Gaps = 112/545 (20%)
Query: 7 VLSLPLLLLPAAPPPAGGCPARCECTV-----------QTRAVACTRRRLTAVPDGIPAE 55
+L L + L A CP C C + + V C L P +PA
Sbjct: 11 LLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPAN 70
Query: 56 TRLL-----------------------ELSRNRIRCLNPGDLAALPALEELDLSENAIAH 92
T++L +LS+N + + ++ +P L + L EN +
Sbjct: 71 TQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
Query: 93 VEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSL 152
+ + L L+ L + N L I PG F L NL L L+ N+L ++ F L +L
Sbjct: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNL 190
Query: 153 RRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIAS 212
L +G+N ++ + F L+ L L + NLT + +L L +L ++
Sbjct: 191 EILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESI--------- 241
Query: 213 LEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHL 272
S + VP AL+ +L
Sbjct: 242 ---------------------------------------SFYDNRLIKVPHVALQKVVNL 262
Query: 273 TCLNLSHNPISTVPRGSFRDLVRLRELHL--------------------------AGALL 306
L+L+ NPI+ + RG F +++ L+EL + L
Sbjct: 263 KFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRL 322
Query: 307 AVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQR 366
+ + P AF L ++ L L++N LS L T S+ L+ + + NP+ CDC + W+
Sbjct: 323 SYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMN 382
Query: 367 RKTLNF-DGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDV 425
+ + F + C P E +G +R + + E +C E + AG V
Sbjct: 383 KTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMME--ICLPLIAPESFPSNLNVEAGSYV 440
Query: 426 RFLCRAEGEPAPTVAWVTPQ-HRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTCVASN 484
F CRA EP P + W+TP + + T + V GTL+I P++ G YTC+A+N
Sbjct: 441 SFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATN 500
Query: 485 AGGND 489
G D
Sbjct: 501 LVGAD 505
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 154 bits (388), Expect = 3e-37
Identities = 130/545 (23%), Positives = 211/545 (38%), Gaps = 112/545 (20%)
Query: 7 VLSLPLLLLPAAPPPAGGCPARCECTV-----------QTRAVACTRRRLTAVPDGIPAE 55
+L L + L A CP C C + + V C L P +PA
Sbjct: 11 LLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPAN 70
Query: 56 TRLL-----------------------ELSRNRIRCLNPGDLAALPALEELDLSENAIAH 92
T++L +LS+N + + ++ +P L + L EN +
Sbjct: 71 TQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
Query: 93 VEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSL 152
+ + L L+ L + N L I PG F L NL L L+ N+L ++ F L +L
Sbjct: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNL 190
Query: 153 RRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIAS 212
L +G+N ++ + F L+ L L + NLT + +L L +L ++
Sbjct: 191 EILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESI--------- 241
Query: 213 LEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHL 272
S + VP AL+ +L
Sbjct: 242 ---------------------------------------SFYDNRLIKVPHVALQKVVNL 262
Query: 273 TCLNLSHNPISTVPRGSFRDLVRLRELHL--------------------------AGALL 306
L+L+ NPI+ + RG F +++ L+EL + L
Sbjct: 263 KFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRL 322
Query: 307 AVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQR 366
+ + P AF L ++ L L++N LS L T S+ L+ + + NP+ CDC + W+
Sbjct: 323 SYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMN 382
Query: 367 RKTLNF-DGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDV 425
+ + F + C P E +G +R + + E +C E + AG V
Sbjct: 383 KTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMME--ICLPLIAPESFPSNLNVEAGSYV 440
Query: 426 RFLCRAEGEPAPTVAWVTPQ-HRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTCVASN 484
F CRA EP P + W+TP + + T + V GTL+I P++ G YTC+A+N
Sbjct: 441 SFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATN 500
Query: 485 AGGND 489
G D
Sbjct: 501 LVGAD 505
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 154 bits (388), Expect = 3e-37
Identities = 130/545 (23%), Positives = 211/545 (38%), Gaps = 112/545 (20%)
Query: 7 VLSLPLLLLPAAPPPAGGCPARCECTV-----------QTRAVACTRRRLTAVPDGIPAE 55
+L L + L A CP C C + + V C L P +PA
Sbjct: 11 LLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPAN 70
Query: 56 TRLL-----------------------ELSRNRIRCLNPGDLAALPALEELDLSENAIAH 92
T++L +LS+N + + ++ +P L + L EN +
Sbjct: 71 TQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
Query: 93 VEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSL 152
+ + L L+ L + N L I PG F L NL L L+ N+L ++ F L +L
Sbjct: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNL 190
Query: 153 RRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIAS 212
L +G+N ++ + F L+ L L + NLT + +L L +L ++
Sbjct: 191 EILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESI--------- 241
Query: 213 LEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHL 272
S + VP AL+ +L
Sbjct: 242 ---------------------------------------SFYDNRLIKVPHVALQKVVNL 262
Query: 273 TCLNLSHNPISTVPRGSFRDLVRLRELHL--------------------------AGALL 306
L+L+ NPI+ + RG F +++ L+EL + L
Sbjct: 263 KFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRL 322
Query: 307 AVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQR 366
+ + P AF L ++ L L++N LS L T S+ L+ + + NP+ CDC + W+
Sbjct: 323 SYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMN 382
Query: 367 RKTLNF-DGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDV 425
+ + F + C P E +G +R + + E +C E + AG V
Sbjct: 383 KTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMME--ICLPLIAPESFPSNLNVEAGSYV 440
Query: 426 RFLCRAEGEPAPTVAWVTPQ-HRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTCVASN 484
F CRA EP P + W+TP + + T + V GTL+I P++ G YTC+A+N
Sbjct: 441 SFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATN 500
Query: 485 AGGND 489
G D
Sbjct: 501 LVGAD 505
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 153 bits (387), Expect = 4e-37
Identities = 164/610 (26%), Positives = 251/610 (41%), Gaps = 105/610 (17%)
Query: 6 CVLSLPLLLL-----PAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLE 60
C+L L LLLL AA P C A C C ++ C R L A+P +P+ TR L
Sbjct: 17 CLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGD--SLDCGGRGLAALPGDLPSWTRSLN 74
Query: 61 LSRNRIRCLNPGDLAALPALEE-------------------------------------- 82
LS N++ ++P LP L+E
Sbjct: 75 LSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQ 134
Query: 83 ---------LDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFT---------- 123
LDLS N I V F + P ++ L L GN++ + G F
Sbjct: 135 LKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLR 194
Query: 124 --------------RLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRA 169
+L LT LDL+ N++ ++ TFQ L+SL L++ N++ ++ A
Sbjct: 195 LSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGA 254
Query: 170 FAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGL--LHL 227
F GL + L LE +L ++ SL L +L L L + +IA + + + L L L
Sbjct: 255 FWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVL 314
Query: 228 EIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTV-- 285
+N L+E + L L++ LS H +I+ + A + L L+L HN IS
Sbjct: 315 SFNNLTRLDEESLAELSSLSVLRLS--HNSISHIAEGAFKGLRSLRVLDLDHNEISGTIE 372
Query: 286 -PRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTL 344
G+F L L +L L G + V +AF GL + LNL N + +++ F + L
Sbjct: 373 DTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNL 432
Query: 345 ETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPA-CATPAEVRGDALRNLPDSVLFEYFV 403
+ L + + CDC+L W+ + A CA P ++G ++ ++P E FV
Sbjct: 433 KELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPP----ESFV 488
Query: 404 C---RKPKIRERRLQRVTATAGEDVRFLCRAEGEPAP--TVAWVTPQHRPVTA------- 451
C KP+I + + A G+D+RF C A + T AW A
Sbjct: 489 CDDFLKPQIITQP-ETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVH 547
Query: 452 TSAGRARVLPGGT-LEIQDARPQDSGTYTCVASN-AGGNDTYFATLTVRPEPAANRTPGE 509
A V+ T L ++ G Y CV +N G ++ A LTV P+ +TP +
Sbjct: 548 VHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHD 607
Query: 510 AHNETLAALR 519
T R
Sbjct: 608 ITIRTTTMAR 617
Score = 47.4 bits (111), Expect = 4e-05
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 426 RFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLE-IQDARPQDSGTYTCVASN 484
R C A G P P +AW A R V+P + I D + D+G Y+C A N
Sbjct: 617 RLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQN 676
Query: 485 AGGNDTYFATLTVRPEPA 502
+ G+ + ATLTV P+
Sbjct: 677 SAGSISANATLTVLETPS 694
Score = 46.6 bits (109), Expect = 6e-05
Identities = 34/126 (26%), Positives = 54/126 (42%), Gaps = 9/126 (7%)
Query: 414 LQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTL-EIQDARP 472
L+ + GE V C+A G P P + W RP++ T R + P L +Q+
Sbjct: 699 LEDRVVSVGETVALQCKATGNPPPRITWFKGD-RPLSLTE--RHHLTPDNQLLVVQNVVA 755
Query: 473 QDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTPGEAHNETLAALRAPLDLTTILVSTA 532
+D+G YTC SN G + + L+V P + T+A + + +L S
Sbjct: 756 EDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVS-----SIVLTSLV 810
Query: 533 MGCITF 538
CI +
Sbjct: 811 WVCIIY 816
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 150 bits (380), Expect = 2e-36
Identities = 113/349 (32%), Positives = 161/349 (46%), Gaps = 27/349 (7%)
Query: 155 LEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLE 214
L + DN + V RR A + L L+L R + ++ + LR+L AL L + SL
Sbjct: 64 LRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLG 123
Query: 215 DQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGL--NLTSLSVTHTNITAVPAAALRHQAHL 272
+ R L L HL + N L +AAG+L L L +++ N+ +P AL ++
Sbjct: 124 EGQLRGLVNLRHLILSN-NQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNV 182
Query: 273 TCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLST 332
L L HN +++VP G+F L +L L + L + P R L + S
Sbjct: 183 NTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFS-RLPLLARPRGSPASA 241
Query: 333 LEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRN 392
L L GNPL C+C L+W+ + L + L ACA+P + G
Sbjct: 242 L------------VLAFGGNPLHCNCELVWL----RRLAREDDLEACASPPALGGRYFWA 285
Query: 393 LPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTAT 452
+ + E FVC P + R + AG CRA G+P P V WV+PQ R + +
Sbjct: 286 VGE----EEFVCEPPVVTHRS-PPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNS 340
Query: 453 SAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEP 501
S RAR P GTLE+ P D G +TC+A+NA G T LTV P P
Sbjct: 341 S--RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPP 387
Score = 95.1 bits (235), Expect = 2e-19
Identities = 80/234 (34%), Positives = 100/234 (42%), Gaps = 32/234 (13%)
Query: 5 LCVLSLPLLLLPAAP---PPAGG----CPARCECTVQTR--AVACTRRRLTAVPDGIPAE 55
+ +L L L LLP AP PP CP RC C Q+ +V C L VP +
Sbjct: 1 MAILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRR 60
Query: 56 TRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLK 115
L L+ N I + DLA + L L LS N I HV GAFA+L LR L L GN+L
Sbjct: 61 AAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLT 120
Query: 116 LIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLA 175
+ G L NL L LS N+L L D
Sbjct: 121 SLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAE-----------------------T 157
Query: 176 LEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI 229
LE+L L NL L E+LG L ++ L L H +AS+ F RL L L++
Sbjct: 158 LEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDM 211
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 149 bits (375), Expect = 9e-36
Identities = 148/514 (28%), Positives = 234/514 (45%), Gaps = 47/514 (9%)
Query: 36 RAVACTRRRLTAVPD--GIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHV 93
R V L +P+ + A LL L+ NRI + P L +LE LDLS N I+ +
Sbjct: 101 REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 160
Query: 94 ----------------------EPGAFANLPR-LRVLRLRGNQLKLIPPGVFTRLDNLTL 130
EPG F NL L VL+L N++ IPP +F +L L
Sbjct: 161 QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQH 219
Query: 131 LDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALS 190
L+L+ NK+ + TFQ L +L+ L++ N + + AF GL +E L L+ NLT ++
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
Query: 191 GESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNL-T 249
L L L L L AI + + L L++ + L + S GL+L
Sbjct: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLN 338
Query: 250 SLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTV---PRGSFRDLVRLRELHLAGALL 306
+L + + ++ + A R + L L+L +N IS G+F L +LR L L G +
Sbjct: 339 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 398
Query: 307 AVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQR 366
+ +AF GL + L+LS+N + +L+ + F + L+ L ++ + L CDC+L W+ Q
Sbjct: 399 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 458
Query: 367 RKTLNFDGRLPA-CATPAEVRGDALRNL-PDSVLFEYFVCRKPKIRERRLQRVTATAGED 424
NF + A CA P ++G ++ + PD + + F KP+I + + +A G +
Sbjct: 459 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDF--PKPQITVQP-ETQSAIKGSN 515
Query: 425 VRFLCRA--EGEPAPTVAWVTPQHRPVTATSAGRARVLPGG--------TLEIQDARPQD 474
+ F+C A + T AW A A + G L +++
Sbjct: 516 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 575
Query: 475 SGTYTCVASN-AGGNDTYFATLTVRPEPAANRTP 507
G Y CV SN G + + A LTV P+ +TP
Sbjct: 576 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP 609
Score = 52.4 bits (124), Expect = 1e-06
Identities = 31/87 (35%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 417 VTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLP-GGTLEIQDARPQDS 475
+T AG R C A G PAP +AW A R V+P I D + +D
Sbjct: 612 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 671
Query: 476 GTYTCVASNAGGNDTYFATLTVRPEPA 502
G Y+C A N+ G+ + ATLTV P+
Sbjct: 672 GVYSCTAQNSAGSISANATLTVLETPS 698
Score = 40.0 bits (92), Expect = 0.006
Identities = 30/88 (34%), Positives = 37/88 (42%), Gaps = 4/88 (4%)
Query: 418 TATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEI-QDARPQDSG 476
T T GE C A G P P + W T P+ T R G L I D+ D+G
Sbjct: 707 TVTKGETAVLQCIAGGSPPPKLNW-TKDDSPLVVTE--RHFFAAGNQLLIIVDSDVSDAG 763
Query: 477 TYTCVASNAGGNDTYFATLTVRPEPAAN 504
YTC SN G + L+V P P +
Sbjct: 764 KYTCEMSNTLGTERGNVRLSVIPTPTCD 791
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 149 bits (375), Expect = 9e-36
Identities = 148/514 (28%), Positives = 234/514 (45%), Gaps = 47/514 (9%)
Query: 36 RAVACTRRRLTAVPD--GIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHV 93
R V L +P+ + A LL L+ NRI + P L +LE LDLS N I+ +
Sbjct: 41 REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 100
Query: 94 ----------------------EPGAFANLPR-LRVLRLRGNQLKLIPPGVFTRLDNLTL 130
EPG F NL L VL+L N++ IPP +F +L L
Sbjct: 101 QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQH 159
Query: 131 LDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALS 190
L+L+ NK+ + TFQ L +L+ L++ N + + AF GL +E L L+ NLT ++
Sbjct: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
Query: 191 GESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNL-T 249
L L L L L AI + + L L++ + L + S GL+L
Sbjct: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLN 278
Query: 250 SLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTV---PRGSFRDLVRLRELHLAGALL 306
+L + + ++ + A R + L L+L +N IS G+F L +LR L L G +
Sbjct: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338
Query: 307 AVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQR 366
+ +AF GL + L+LS+N + +L+ + F + L+ L ++ + L CDC+L W+ Q
Sbjct: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398
Query: 367 RKTLNFDGRLPA-CATPAEVRGDALRNL-PDSVLFEYFVCRKPKIRERRLQRVTATAGED 424
NF + A CA P ++G ++ + PD + + F KP+I + + +A G +
Sbjct: 399 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDF--PKPQITVQP-ETQSAIKGSN 455
Query: 425 VRFLCRA--EGEPAPTVAWVTPQHRPVTATSAGRARVLPGG--------TLEIQDARPQD 474
+ F+C A + T AW A A + G L +++
Sbjct: 456 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515
Query: 475 SGTYTCVASN-AGGNDTYFATLTVRPEPAANRTP 507
G Y CV SN G + + A LTV P+ +TP
Sbjct: 516 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP 549
Score = 98.6 bits (244), Expect = 1e-20
Identities = 79/279 (28%), Positives = 150/279 (53%), Gaps = 9/279 (3%)
Query: 84 DLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLD 143
DLS N ++ ++ + ++L LR ++L N+L+ I P + N+TLL L+ N++V +L
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILP 78
Query: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHL-RSLGA 202
++ SL L++ N++ + + AF L L+ L L +T++ +L +L
Sbjct: 79 EHLKEFQSLETLDLSSNNISEL-QTAFPA-LQLKYLYLNSNRVTSMEPGYFDNLANTLLV 136
Query: 203 LRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-LTSLSVTHTNITAV 261
L+L I+++ + F +LP L HLE+ N ++ V + +GL L SL + +T +
Sbjct: 137 LKLNRNRISAIPPKMF-KLPQLQHLEL-NRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 194
Query: 262 PAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIR 321
A +++ L L HN ++ + +G L+ L+ELHL+ + + P A+ +++
Sbjct: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLS 254
Query: 322 LLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA--CDC 358
L+L+ N LS L++S+F ++ L TL + N ++ DC
Sbjct: 255 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC 293
Score = 52.4 bits (124), Expect = 1e-06
Identities = 31/87 (35%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 417 VTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLP-GGTLEIQDARPQDS 475
+T AG R C A G PAP +AW A R V+P I D + +D
Sbjct: 552 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611
Query: 476 GTYTCVASNAGGNDTYFATLTVRPEPA 502
G Y+C A N+ G+ + ATLTV P+
Sbjct: 612 GVYSCTAQNSAGSISANATLTVLETPS 638
Score = 40.0 bits (92), Expect = 0.006
Identities = 30/88 (34%), Positives = 37/88 (42%), Gaps = 4/88 (4%)
Query: 418 TATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEI-QDARPQDSG 476
T T GE C A G P P + W T P+ T R G L I D+ D+G
Sbjct: 647 TVTKGETAVLQCIAGGSPPPKLNW-TKDDSPLVVTE--RHFFAAGNQLLIIVDSDVSDAG 703
Query: 477 TYTCVASNAGGNDTYFATLTVRPEPAAN 504
YTC SN G + L+V P P +
Sbjct: 704 KYTCEMSNTLGTERGNVRLSVIPTPTCD 731
Score = 32.3 bits (72), Expect = 1.3
Identities = 24/85 (28%), Positives = 39/85 (45%), Gaps = 1/85 (1%)
Query: 271 HLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLL 330
H++ +LSHN +S + S L LRE+ L L + P I LL+L+ N +
Sbjct: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRI 73
Query: 331 STLEESTFHSVNTLETLRVDGNPLA 355
+ +LETL + N ++
Sbjct: 74 VEILPEHLKEFQSLETLDLSSNNIS 98
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 145 bits (366), Expect = 1e-34
Identities = 117/358 (32%), Positives = 170/358 (47%), Gaps = 12/358 (3%)
Query: 7 VLSLPLLLLPA---APPPAG----GCPARCECTVQTRA---VACTRRRLTAVPDGIPAET 56
+LSLP+LL A + P +G GCP C C R V C+ L+ +P + T
Sbjct: 9 LLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFT 68
Query: 57 RLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKL 116
L+LS N I L P L +L LEEL L+ NA+ ++ GAF L L+VL L+ NQL+
Sbjct: 69 SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRH 128
Query: 117 IPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLAL 176
+P L +L L L N + + F LHSLR L + DN L + +AF L AL
Sbjct: 129 VPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSAL 188
Query: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
+ +TL + + + G+L SL L L + I SL + F L L L++ N+ L+
Sbjct: 189 QAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDL-NYNNLD 247
Query: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296
E NL L NI ++P A L ++ NPI V R +F+ L L
Sbjct: 248 EFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPEL 307
Query: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPL 354
R L L GA + E G + L L+ +S+L ++ + + L+ L + N L
Sbjct: 308 RTLTLNGA-SQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 364
Score = 47.0 bits (110), Expect = 5e-05
Identities = 28/81 (34%), Positives = 43/81 (53%)
Query: 275 LNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLE 334
L+LS N IS + L L EL LAG L + AF GL +++L L NN L +
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 335 ESTFHSVNTLETLRVDGNPLA 355
++ +L++LR+D N ++
Sbjct: 131 TEALQNLRSLQSLRLDANHIS 151
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 145 bits (365), Expect = 1e-34
Identities = 112/346 (32%), Positives = 160/346 (46%), Gaps = 8/346 (2%)
Query: 16 PAAPPPAGG--CPARCECTVQTRA----VACTRRRLTAVPDGIPAETRLLELSRNRIRCL 69
P P A G CPA C C+ A V C+ R LT +PDG+P T+ L L N + +
Sbjct: 68 PGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 127
Query: 70 NPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLT 129
P L +L L+L + +EP A L L L L NQL+ + G F L
Sbjct: 128 PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 187
Query: 130 LLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTAL 189
L LS N+L L D F+ L SL L +G N L + AF GL +L EL L L L
Sbjct: 188 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 247
Query: 190 SGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-L 248
L L L L A+ +++ F +LP L L +D L+ VA G+ GL L
Sbjct: 248 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR-NLIAAVAPGAFLGLKAL 306
Query: 249 TSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAV 308
L ++H + + L L LSHN I+++ +F+DL L EL L +
Sbjct: 307 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 366
Query: 309 VEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPL 354
+ ++F GL Q+ +L L +N L ++ F + + + + GN L
Sbjct: 367 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412
Score = 120 bits (302), Expect = 3e-27
Identities = 118/386 (30%), Positives = 177/386 (45%), Gaps = 46/386 (11%)
Query: 54 AETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQ 113
AE R L+LSRN +R + LP L++L L N IA V PGAF L LR L L N+
Sbjct: 256 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 315
Query: 114 LKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGL 173
+ + F L L +L LS N + L TF+DLH L L++G N + ++ R+F GL
Sbjct: 316 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 375
Query: 174 LALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGL--LHLEIDN 231
LE LTL+ L + + L ++ + L + +L +Q FR L L LHLE
Sbjct: 376 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLE--- 432
Query: 232 WPLLEEVAAGSLRGLN-LTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSF 290
L + + GL+ L L + + + +L A L L+L+ N ++ +P F
Sbjct: 433 GSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLF 492
Query: 291 RDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTF------------ 338
+ L +L L L+ LA + A L++ L++S+N L L S
Sbjct: 493 QGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLR 552
Query: 339 -HSVNT-------LETLRVDGNPLACDCRLL----WIVQRRKTL---------NFDGRLP 377
+S+ T LE L ++GNP C C L + +Q + D + P
Sbjct: 553 NNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPP 612
Query: 378 A-------CATPAEVRGDALRNLPDS 396
A CA+P EV G LR+L ++
Sbjct: 613 AYTYNNITCASPPEVVGLDLRDLSEA 638
Score = 80.1 bits (196), Expect = 5e-15
Identities = 56/179 (31%), Positives = 89/179 (49%)
Query: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
+ L L+ NL+++ + +L SLG L L+ + SLE Q L L HL ++ L
Sbjct: 115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 174
Query: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296
L SL +++ ++ + L LNL N ++ +P +FR L L
Sbjct: 175 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 234
Query: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA 355
REL LAG LA ++P F GL ++R L+LS N L ++ + F + L+ L +D N +A
Sbjct: 235 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 293
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 145 bits (365), Expect = 1e-34
Identities = 112/346 (32%), Positives = 160/346 (46%), Gaps = 8/346 (2%)
Query: 16 PAAPPPAGG--CPARCECTVQTRA----VACTRRRLTAVPDGIPAETRLLELSRNRIRCL 69
P P A G CPA C C+ A V C+ R LT +PDG+P T+ L L N + +
Sbjct: 30 PGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 89
Query: 70 NPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLT 129
P L +L L+L + +EP A L L L L NQL+ + G F L
Sbjct: 90 PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 149
Query: 130 LLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTAL 189
L LS N+L L D F+ L SL L +G N L + AF GL +L EL L L L
Sbjct: 150 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 209
Query: 190 SGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-L 248
L L L L A+ +++ F +LP L L +D L+ VA G+ GL L
Sbjct: 210 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR-NLIAAVAPGAFLGLKAL 268
Query: 249 TSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAV 308
L ++H + + L L LSHN I+++ +F+DL L EL L +
Sbjct: 269 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 328
Query: 309 VEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPL 354
+ ++F GL Q+ +L L +N L ++ F + + + + GN L
Sbjct: 329 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
Score = 120 bits (302), Expect = 3e-27
Identities = 118/386 (30%), Positives = 177/386 (45%), Gaps = 46/386 (11%)
Query: 54 AETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQ 113
AE R L+LSRN +R + LP L++L L N IA V PGAF L LR L L N+
Sbjct: 218 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 277
Query: 114 LKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGL 173
+ + F L L +L LS N + L TF+DLH L L++G N + ++ R+F GL
Sbjct: 278 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 337
Query: 174 LALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGL--LHLEIDN 231
LE LTL+ L + + L ++ + L + +L +Q FR L L LHLE
Sbjct: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLE--- 394
Query: 232 WPLLEEVAAGSLRGLN-LTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSF 290
L + + GL+ L L + + + +L A L L+L+ N ++ +P F
Sbjct: 395 GSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLF 454
Query: 291 RDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTF------------ 338
+ L +L L L+ LA + A L++ L++S+N L L S
Sbjct: 455 QGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLR 514
Query: 339 -HSVNT-------LETLRVDGNPLACDCRLL----WIVQRRKTL---------NFDGRLP 377
+S+ T LE L ++GNP C C L + +Q + D + P
Sbjct: 515 NNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPP 574
Query: 378 A-------CATPAEVRGDALRNLPDS 396
A CA+P EV G LR+L ++
Sbjct: 575 AYTYNNITCASPPEVVGLDLRDLSEA 600
Score = 80.1 bits (196), Expect = 5e-15
Identities = 56/179 (31%), Positives = 89/179 (49%)
Query: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
+ L L+ NL+++ + +L SLG L L+ + SLE Q L L HL ++ L
Sbjct: 77 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 136
Query: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296
L SL +++ ++ + L LNL N ++ +P +FR L L
Sbjct: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196
Query: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA 355
REL LAG LA ++P F GL ++R L+LS N L ++ + F + L+ L +D N +A
Sbjct: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 255
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 145 bits (365), Expect = 1e-34
Identities = 111/348 (31%), Positives = 157/348 (45%), Gaps = 27/348 (7%)
Query: 155 LEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLE 214
L + DN + V RR FA + +L LTL R + ++ + LR+L AL L +A +
Sbjct: 70 LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVR 129
Query: 215 DQNFRRLPGLLHLEIDNWPLLE-EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLT 273
R L L HL + N + E AA + L +++ N+ A+P A+ +L
Sbjct: 130 GDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLN 189
Query: 274 CLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTL 333
L L HN I + G+F L +L L + L + P L
Sbjct: 190 TLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDG----------------LFLR 233
Query: 334 EESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRNL 393
+ T T T+ GNPL C+C LLW+ RR T D L CATP + ++
Sbjct: 234 SQGTGPKPPTPLTVSFGGNPLHCNCELLWL--RRLTREDD--LETCATPEHLTDRYFWSI 289
Query: 394 PDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATS 453
P+ E F+C P I + R G+ V CRA G+P P V WV P R + +S
Sbjct: 290 PE----EEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSS 345
Query: 454 AGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEP 501
R RV GTL++ +DSGT+TC+ASNA G T + V P P
Sbjct: 346 --RTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLP 391
Score = 81.6 bits (200), Expect = 2e-15
Identities = 74/225 (32%), Positives = 101/225 (44%), Gaps = 28/225 (12%)
Query: 9 SLPLLLLPAAPPPAGG-CPARCEC--TVQTRAVACTRRRLTAVPDGIPAETRLLELSRNR 65
+LP LLL A G CP RC C T + C + L VP I L L+ N
Sbjct: 17 ALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNF 76
Query: 66 IRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRL 125
I + D A + +L L LS N I V GAFA+L LR L L N+L + R
Sbjct: 77 IAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEV------RG 130
Query: 126 DNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAF-AGLLALEELTLERC 184
D L + L +LR L +G+N + V AF A L +E+L L
Sbjct: 131 DQL------------------RGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYN 172
Query: 185 NLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI 229
NL AL E++G + +L L L H I + + F +L L+ L++
Sbjct: 173 NLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDM 217
Score = 38.9 bits (89), Expect = 0.013
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 1/83 (1%)
Query: 57 RLLELSRNRIRCLNPGDLAA-LPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLK 115
R L L N+IR + A L +E+LDLS N + + A + L L L N +
Sbjct: 140 RHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLID 199
Query: 116 LIPPGVFTRLDNLTLLDLSENKL 138
I G F +L L LD++ N+L
Sbjct: 200 HIAEGTFVQLHKLVRLDMTSNRL 222
Score = 38.5 bits (88), Expect = 0.018
Identities = 27/84 (32%), Positives = 39/84 (46%), Gaps = 1/84 (1%)
Query: 42 RRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANL 101
RR +A D + L+LS N + L + + L L L N I H+ G F L
Sbjct: 150 RRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQL 209
Query: 102 PRLRVLRLRGNQLKLIPP-GVFTR 124
+L L + N+L +PP G+F R
Sbjct: 210 HKLVRLDMTSNRLHKLPPDGLFLR 233
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 144 bits (362), Expect = 3e-34
Identities = 124/416 (29%), Positives = 191/416 (45%), Gaps = 44/416 (10%)
Query: 25 CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNP-GDLAALPALEEL 83
CP +C C T V C+ ++L +P+ IP T L L+ N L G LP L ++
Sbjct: 506 CPEKCRCEGTT--VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKI 563
Query: 84 DLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLD 143
+ S N I +E GAF + + L N+L+ + +F L++L L L N++ + +
Sbjct: 564 NFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGN 623
Query: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLE----RCNL-TALSGESL---- 194
+F L S+R L + DN + V+ AF L +L L L CN A GE L
Sbjct: 624 DSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKR 683
Query: 195 ---GHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNW--PL---------LEEVAA 240
G+ R L+ + I + Q+F G DN PL L+ V
Sbjct: 684 IVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG----NDDNSCSPLSRCPTECTCLDTVVR 739
Query: 241 GSLRGL---------NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFR 291
S +GL ++T L + T VP L + HLT ++LS+N IST+ SF
Sbjct: 740 CSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE-LSNYKHLTLIDLSNNRISTLSNQSFS 798
Query: 292 DLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDG 351
++ +L L L+ L + P+ F GL+ +RLL+L N +S + E F+ ++ L L +
Sbjct: 799 NMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGA 858
Query: 352 NPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKP 407
NPL CDC + W+ K+ + + CA P E+ L P + F C+ P
Sbjct: 859 NPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPS----KKFTCQGP 910
Score = 137 bits (344), Expect = 4e-32
Identities = 117/378 (30%), Positives = 167/378 (44%), Gaps = 33/378 (8%)
Query: 8 LSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIR 67
L L L +L P A CPA+C C+ T V C L +VP IP T L+L+ N I
Sbjct: 13 LGLVLAILNKVAPQA--CPAQCSCSGST--VDCHGLALRSVPRNIPRNTERLDLNGNNIT 68
Query: 68 CLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDN 127
+ D A L L L L EN I+ +E GAF +L L LRL N L+L P +F
Sbjct: 69 RITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAK 128
Query: 128 LTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLT 187
L LDLSEN++ + F+ ++ L++ N + + AF L LE LTL N+T
Sbjct: 129 LYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNIT 188
Query: 188 ALSGESLGHLRSLGALRLR--------HLAIAS--LEDQN----FRRLPGLLHLEIDNWP 233
LS S H+ L RL HLA S L + + + G HL N
Sbjct: 189 RLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVA 248
Query: 234 LLE--EVAAGSLRGLNLTSLSVTH--------TNITAVPAAALRH-----QAHLTCLNLS 278
++ E + S SV H NI L +T + L
Sbjct: 249 EVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLE 308
Query: 279 HNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTF 338
N I +P G+F +LR + L+ ++ + P AF GLR + L L N ++ L +S F
Sbjct: 309 QNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLF 368
Query: 339 HSVNTLETLRVDGNPLAC 356
+ +L+ L ++ N + C
Sbjct: 369 EGLFSLQLLLLNANKINC 386
Score = 123 bits (309), Expect = 4e-28
Identities = 106/425 (24%), Positives = 179/425 (42%), Gaps = 70/425 (16%)
Query: 25 CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELD 84
CPA C C+ V C + LT +P +P + L +N I+ + PG + L +D
Sbjct: 273 CPAACTCS--NNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRID 330
Query: 85 LSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDY 144
LS N I+ + P AF L L L L GN++ +P +F L +L LL L+ NK+ L
Sbjct: 331 LSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 390
Query: 145 TFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLER------CNLTALSG------- 191
FQDLH+L L + DN L +++ F+ L A++ + L + C+L L+
Sbjct: 391 AFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPI 450
Query: 192 ESLGHLRSLGALRLRHLAIASLEDQNFR-------RLPGLLHLEID-NWPLLEEVAAGSL 243
E+ G R RL + I ++ + FR +PG + ++A
Sbjct: 451 ETSG-ARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEK 509
Query: 244 RGLNLTSLSVTHTNITAVPAAALRHQAHLTC----------------------LNLSHNP 281
T++ ++ + +P ++ A L +N S+N
Sbjct: 510 CRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNK 569
Query: 282 ISTVPRGS------------------------FRDLVRLRELHLAGALLAVVEPQAFLGL 317
I+ + G+ F+ L L+ L L + V +F+GL
Sbjct: 570 ITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGL 629
Query: 318 RQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLP 377
+RLL+L +N ++T+ F ++++L TL + NP C+C L W+ + + P
Sbjct: 630 SSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNP 689
Query: 378 ACATP 382
C P
Sbjct: 690 RCQKP 694
Score = 79.3 bits (194), Expect = 9e-15
Identities = 57/211 (27%), Positives = 91/211 (43%), Gaps = 24/211 (11%)
Query: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
E L L N+T ++ LR L L+L I+++E F+ L L L ++
Sbjct: 58 ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNR----- 112
Query: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296
++ P A L L+LS N I +PR +FR V +
Sbjct: 113 -------------------NHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDI 153
Query: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLAC 356
+ L L ++ +E AF LR + +L L+NN ++ L ++F+ + L T R+ N L C
Sbjct: 154 KNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYC 213
Query: 357 DCRLLWIVQRRKTLNFDGRLPACATPAEVRG 387
DC L W+ + G C P+ +RG
Sbjct: 214 DCHLAWLSDWLRQRPRVGLYTQCMGPSHLRG 244
Score = 79.0 bits (193), Expect = 1e-14
Identities = 49/142 (34%), Positives = 72/142 (50%), Gaps = 3/142 (2%)
Query: 21 PAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPAL 80
P CP C C V C+ + L +P GIP + L L N+ L P +L+ L
Sbjct: 723 PLSRCPTECTCL--DTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT-LVPKELSNYKHL 779
Query: 81 EELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVI 140
+DLS N I+ + +F+N+ +L L L N+L+ IPP F L +L LL L N + +
Sbjct: 780 TLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISV 839
Query: 141 LLDYTFQDLHSLRRLEVGDNDL 162
+ + F DL +L L +G N L
Sbjct: 840 VPEGAFNDLSALSHLAIGANPL 861
Score = 43.5 bits (101), Expect = 5e-04
Identities = 33/104 (31%), Positives = 50/104 (48%), Gaps = 6/104 (5%)
Query: 260 AVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQ 319
A PA + + C L+ + +VPR R+ RL L G + + F GLR
Sbjct: 27 ACPAQCSCSGSTVDCHGLA---LRSVPRNIPRNTERL---DLNGNNITRITKTDFAGLRH 80
Query: 320 IRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWI 363
+R+L L N +ST+E F + LE LR++ N L LL++
Sbjct: 81 LRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFL 124
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 144 bits (362), Expect = 3e-34
Identities = 127/443 (28%), Positives = 190/443 (42%), Gaps = 78/443 (17%)
Query: 24 GCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEEL 83
GCP+ C C+ + V CT R+ AVP +P L++ I LN + AL L
Sbjct: 30 GCPSECTCS-RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIAL 88
Query: 84 DLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLD 143
+ +N ++ + PGAF NL LR L L N+L+++P G+F LD+L L LS N+L+ +
Sbjct: 89 RIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 148
Query: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGAL 203
F +L+ L++ N L ++ AF L+ L +L L + +LT +S HL +L L
Sbjct: 149 AHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVL 208
Query: 204 RLRHLAIASLEDQNFRRL-----------------PGLLH-------LEIDN-------- 231
RL + + F L PGL H L + N
Sbjct: 209 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 268
Query: 232 -----WPLLEEVA--AGSLRGL---------NLTSLSVTHTNITAVPAAALRHQAHLTCL 275
P L + SL+ L NL L + +I+++P + L L
Sbjct: 269 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 328
Query: 276 NLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEE 335
LS N IS + G+F L LREL L L ++ F L ++ ++L NN L L
Sbjct: 329 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 388
Query: 336 STFHSVNTLET------------------------LRVDGNPLACDCRLL----WIVQRR 367
+ F +VN L LR+ NP CD +L W++ +
Sbjct: 389 NIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 448
Query: 368 KTLNFDGRLPACATPAEVRGDAL 390
L D +P C +PA VRG +L
Sbjct: 449 PRLGTD-TVPVCFSPANVRGQSL 470
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 144 bits (362), Expect = 3e-34
Identities = 127/443 (28%), Positives = 190/443 (42%), Gaps = 78/443 (17%)
Query: 24 GCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEEL 83
GCP+ C C+ + V CT R+ AVP +P L++ I LN + AL L
Sbjct: 24 GCPSECTCS-RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIAL 82
Query: 84 DLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLD 143
+ +N ++ + PGAF NL LR L L N+L+++P G+F LD+L L LS N+L+ +
Sbjct: 83 RIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 142
Query: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGAL 203
F +L+ L++ N L ++ AF L+ L +L L + +LT +S HL +L L
Sbjct: 143 AHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVL 202
Query: 204 RLRHLAIASLEDQNFRRL-----------------PGLLH-------LEIDN-------- 231
RL + + F L PGL H L + N
Sbjct: 203 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 262
Query: 232 -----WPLLEEVA--AGSLRGL---------NLTSLSVTHTNITAVPAAALRHQAHLTCL 275
P L + SL+ L NL L + +I+++P + L L
Sbjct: 263 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 322
Query: 276 NLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEE 335
LS N IS + G+F L LREL L L ++ F L ++ ++L NN L L
Sbjct: 323 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 382
Query: 336 STFHSVNTLET------------------------LRVDGNPLACDCRLL----WIVQRR 367
+ F +VN L LR+ NP CD +L W++ +
Sbjct: 383 NIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 442
Query: 368 KTLNFDGRLPACATPAEVRGDAL 390
L D +P C +PA VRG +L
Sbjct: 443 PRLGTD-TVPVCFSPANVRGQSL 464
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 143 bits (361), Expect = 4e-34
Identities = 124/374 (33%), Positives = 166/374 (44%), Gaps = 39/374 (10%)
Query: 22 AGGCPARCECTVQTR--AVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPA 79
A CPA C C+ R +V C R L VP +P E ++L RN +R L LP+
Sbjct: 28 ARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPS 87
Query: 80 LEELDLSENAIAHVEPGAFANLPRLRVLRLRGN-QLKLIPPGVFTRLDNLTLLDLSENKL 138
L L L N ++ + PGAF LPRL LRL N L+ + F L L LDL+ +L
Sbjct: 88 LRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRL 147
Query: 139 VILLDYTFQDLHSLRRLEVGDNDLVFVSRR---AFAGLLALEELTLERCNLTALSGESLG 195
+ + +L +LR L DN + RR A GL L LER + A++ SL
Sbjct: 148 FSVPERLLAELPALRELAAFDN----LFRRVPGALRGLANLTHAHLERGRIEAVASSSLQ 203
Query: 196 HLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTH 255
LR L +L L+ + ++ F L HL + N LL E+ A + RGL
Sbjct: 204 GLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLL-NDNLLAELPADAFRGLR-------- 254
Query: 256 TNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFL 315
L LNL N + V R F DL L L+L +A VE AF
Sbjct: 255 ---------------RLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQ 299
Query: 316 GLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGR 375
L + L+L+ N L+ L F L L + NP CDCRL W+ R + GR
Sbjct: 300 NLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWL---RDWMEGSGR 356
Query: 376 LP--ACATPAEVRG 387
+ CA+P V G
Sbjct: 357 VTDVPCASPGSVAG 370
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 142 bits (358), Expect = 9e-34
Identities = 96/357 (26%), Positives = 163/357 (45%), Gaps = 24/357 (6%)
Query: 155 LEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLE 214
L + DN + + R+ FA + +L +LTL R ++ ++ + LR+L AL L + +
Sbjct: 56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
Query: 215 DQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTC 274
+ F L L HL ++N L + L L +++ N+ +P A+ L
Sbjct: 116 NDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHT 175
Query: 275 LNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLE 334
L+L HN I +P+G+F L ++ L + L + P Q+ + +
Sbjct: 176 LSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATS------GIIS 229
Query: 335 ESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRNLP 394
STF L GNPL C+C LLW+ + L+ + L CA+P + G ++P
Sbjct: 230 PSTF-------ALSFGGNPLHCNCELLWL----RRLSREDDLETCASPPLLTGRYFWSIP 278
Query: 395 DSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSA 454
+ E F+C P I R + G+ C+A G+P P + W++P+ + + ++A
Sbjct: 279 E----EEFLCEPPLI-TRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLI--SNA 331
Query: 455 GRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTPGEAH 511
R+ V GTL+I +D+G +TC+ASN G T L + P + H
Sbjct: 332 TRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTNHIH 388
Score = 89.7 bits (221), Expect = 7e-18
Identities = 56/181 (30%), Positives = 92/181 (50%), Gaps = 2/181 (1%)
Query: 25 CPARCECTVQTRAVA--CTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEE 82
CP RC C + + +A C ++ L VP I T L L+ N + + D A + +L +
Sbjct: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
Query: 83 LDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILL 142
L LS N I+ + P AFA+L LR L L N+L I +F+ L NL L L+ N+L ++
Sbjct: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
Query: 143 DYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGA 202
F D+ +L L++ N+L + A +++L L+L+ + + + HL +
Sbjct: 140 STAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTR 199
Query: 203 L 203
L
Sbjct: 200 L 200
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 139 bits (350), Expect = 7e-33
Identities = 103/346 (29%), Positives = 160/346 (46%), Gaps = 29/346 (8%)
Query: 155 LEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLE 214
L +G N ++ +SR+ FA + L +LTL R ++ + S L SL +L L + SL
Sbjct: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLG 116
Query: 215 DQNFRRLPGLLHLEIDNWPL---LEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAH 271
+ R L L HL ++N L +E L L L L +++ N+ +P ++R +
Sbjct: 117 EDTLRGLVNLQHLIVNNNQLGGIADEAFEDFL--LTLEDLDLSYNNLHGLPWDSVRRMVN 174
Query: 272 LTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLS 331
L L+L HN + + G+F DL +L L L L + P Q S
Sbjct: 175 LHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQ----------AS 224
Query: 332 TLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALR 391
L + F + GNPL C+C LLW+ + L D L C +P ++G
Sbjct: 225 ALTATPFAPPLSFS---FGGNPLHCNCELLWL----RRLERDDDLETCGSPGGLKGRYFW 277
Query: 392 NLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTA 451
++ + E FVC P I + ++ G+ C+A G+P+P + WV P R V
Sbjct: 278 HVRE----EEFVCEPPLITQ-HTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGN 332
Query: 452 TSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTV 497
+S R V GTL+I QDSG +TC+A+NA G T +++
Sbjct: 333 SS--RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSI 376
Score = 71.2 bits (173), Expect = 2e-12
Identities = 59/207 (28%), Positives = 89/207 (42%), Gaps = 25/207 (12%)
Query: 25 CPARCECTVQTRAVA--CTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEE 82
CP C C + ++ C + L VP I T L L N I ++ D A + L +
Sbjct: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
Query: 83 LDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILL 142
L LS N I+H++P +F +L LR L L N+L + L NL L ++ N+L +
Sbjct: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
Query: 143 DYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGA 202
D F+D LL LE+L L NL L +S+ + +L
Sbjct: 141 DEAFEDF-----------------------LLTLEDLDLSYNNLHGLPWDSVRRMVNLHQ 177
Query: 203 LRLRHLAIASLEDQNFRRLPGLLHLEI 229
L L H + + + F L L L++
Sbjct: 178 LSLDHNLLDHIAEGTFADLQKLARLDL 204
Score = 40.4 bits (93), Expect = 0.005
Identities = 23/67 (34%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 59 LELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIP 118
L+LS N + L + + L +L L N + H+ G FA+L +L L L N+L+ +P
Sbjct: 154 LDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLP 213
Query: 119 PG-VFTR 124
P +F R
Sbjct: 214 PDPIFAR 220
Score = 34.7 bits (78), Expect = 0.25
Identities = 23/62 (37%), Positives = 30/62 (48%)
Query: 77 LPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSEN 136
L LE+LDLS N + + + + L L L N L I G F L L LDL+ N
Sbjct: 148 LLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSN 207
Query: 137 KL 138
+L
Sbjct: 208 RL 209
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,915,035
Number of Sequences: 37866
Number of extensions: 1121663
Number of successful extensions: 8426
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 343
Number of HSP's successfully gapped in prelim test: 198
Number of HSP's that attempted gapping in prelim test: 3315
Number of HSP's gapped (non-prelim): 2736
length of query: 592
length of database: 18,247,518
effective HSP length: 108
effective length of query: 484
effective length of database: 14,157,990
effective search space: 6852467160
effective search space used: 6852467160
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.