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Search of human proteins with 157042792
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157042792 coiled-coil domain containing 64B [Homo sapiens]
(508 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157042792 coiled-coil domain containing 64B [Homo sapiens] 966 0.0
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 255 8e-68
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 93 7e-19
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 93 7e-19
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 93 7e-19
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 91 2e-18
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 90 4e-18
gi|31982906 cingulin-like 1 [Homo sapiens] 88 2e-17
gi|21735548 centrosomal protein 2 [Homo sapiens] 83 5e-16
gi|148746195 trichohyalin [Homo sapiens] 82 9e-16
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 82 9e-16
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 82 9e-16
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 82 9e-16
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 82 9e-16
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 82 9e-16
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 82 9e-16
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 82 9e-16
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 82 9e-16
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 81 3e-15
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 80 3e-15
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 80 6e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 80 6e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 80 6e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 80 6e-15
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 79 7e-15
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 79 1e-14
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 78 2e-14
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 78 2e-14
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 77 3e-14
gi|16262452 cingulin [Homo sapiens] 77 5e-14
>gi|157042792 coiled-coil domain containing 64B [Homo sapiens]
Length = 508
Score = 966 bits (2498), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MSSPDGPSFPSGPLSGGASPSGDEGFFPFVLERRDSFLGGGPGPEEPEDLALQLQQKEKD 60
MSSPDGPSFPSGPLSGGASPSGDEGFFPFVLERRDSFLGGGPGPEEPEDLALQLQQKEKD
Sbjct: 1 MSSPDGPSFPSGPLSGGASPSGDEGFFPFVLERRDSFLGGGPGPEEPEDLALQLQQKEKD 60
Query: 61 LLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVE 120
LLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVE
Sbjct: 61 LLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVE 120
Query: 121 LEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDA 180
LEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDA
Sbjct: 121 LEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDA 180
Query: 181 LRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEE 240
LRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEE
Sbjct: 181 LRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEE 240
Query: 241 LLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELA 300
LLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELA
Sbjct: 241 LLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELA 300
Query: 301 HSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKE 360
HSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKE
Sbjct: 301 HSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKE 360
Query: 361 VEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQ 420
VEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQ
Sbjct: 361 VEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQ 420
Query: 421 LNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSST 480
LNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSST
Sbjct: 421 LNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSST 480
Query: 481 PRRAAPRFSLRLGPGPAGGFLSNLFRRT 508
PRRAAPRFSLRLGPGPAGGFLSNLFRRT
Sbjct: 481 PRRAAPRFSLRLGPGPAGGFLSNLFRRT 508
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 255 bits (651), Expect = 8e-68
Identities = 172/504 (34%), Positives = 276/504 (54%), Gaps = 42/504 (8%)
Query: 14 LSGGASPSGDEGFFPFVLERRDSFLGGGPGPEEPE----DLALQLQQKEKDLLLAAELGK 69
L+ G PS D G P + L G GP+ P +L ++QKEKDL+LAA LGK
Sbjct: 63 LAAGERPS-DPGEHP---QAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGK 118
Query: 70 MLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALR 129
LLERN+++ RQ E + + ++ E L+QE HELRR R EWE R ELE DV+ L+
Sbjct: 119 ALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQ 178
Query: 130 AQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQA 189
+L Q+ +++ RE++RA+ ELSEQN RL QL++AS+ E++L ++ ALR + +
Sbjct: 179 DELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKN 238
Query: 190 LAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERR 249
+ + RLESLQ E +ML R+++LE ++ EE + +G ++ + +L+L R+
Sbjct: 239 SSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGH 298
Query: 250 EHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQG 309
+ L+L +++ E E + R+LQ +V EL EE LQ + ++ SL SE+ S++ +
Sbjct: 299 DKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELE 358
Query: 310 Q------------------------GADAPGDTPTTRSP--KTRKASSPQPSPPEEILEP 343
Q G D+ +T S ++ + SS + P +
Sbjct: 359 QEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSL--- 415
Query: 344 PKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSA 403
RT+L+ + L + V+ ++ ++L E+ +L+EE R + ++P E L A
Sbjct: 416 ---RTALNELKRLIQSIVD--GMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKA 470
Query: 404 LSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQ 463
+ DRDEA+ K + L+L + ++ SL+ +LL AI+QK+ L+Q+LEAWQDDM VI +Q
Sbjct: 471 IRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQ 530
Query: 464 LRSQRQKELSASASSSTPRRAAPR 487
L KE S A++ +A R
Sbjct: 531 LMDTHLKERSQPAAALCRGHSAGR 554
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 92.8 bits (229), Expect = 7e-19
Identities = 128/496 (25%), Positives = 210/496 (42%), Gaps = 65/496 (13%)
Query: 48 EDLALQLQQ-----KEKDLL--LAAELGKMLLERNEE------LRRQLETLSAQ---HLE 91
EDL L Q KE+ LL AE E E+ LR + E A L
Sbjct: 1010 EDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLR 1069
Query: 92 REERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQ-------DSGR 144
+EE+ +QE +L+R L +E + + VE + E LRAQLG + E Q D G
Sbjct: 1070 KEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGG 1129
Query: 145 ERARALSELSEQNLRLSQ-----QLAQASQTEQELQR-----ELDALRGQCQ---AQALA 191
RA+ L L E L++ + + ++T+ E QR EL+ALRG+ + A
Sbjct: 1130 ARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA 1189
Query: 192 GAELRTRLESLQGE-NQMLQSRRQDLEAQIRGLR--------------EEVEKGEGRLQT 236
ELR++ E E + L+ + EA ++ LR E+ +G+G +
Sbjct: 1190 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEK 1249
Query: 237 THEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQ 296
T L L E E EL ++ E RRL+ ++ E+ + R D + + A
Sbjct: 1250 TR---LALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEV--QGRAGDGERARAEAA 1304
Query: 297 SELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEIL 356
+L + + + GA ++ T R K ++ Q +E+L+ + R L+ +
Sbjct: 1305 EKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ-EETRAKLALGSRV 1363
Query: 357 EEKEVEVAKLQDEISLQQAELQSLREELQ-RQKEL----RAQEDPGEALHSALSDRDEAV 411
E E A L++++ + A + ELQ Q +L R QE+ AL + R A
Sbjct: 1364 RAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAA 1423
Query: 412 NKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKE 471
+A L+ +L + D L R R ++ T +LE Q+V + + ++ +
Sbjct: 1424 REAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE---QQRQLVSTLEKKQRKFDQ 1480
Query: 472 LSASASSSTPRRAAPR 487
L A ++ R R
Sbjct: 1481 LLAEEKAAVLRAVEER 1496
Score = 75.1 bits (183), Expect = 1e-13
Identities = 127/499 (25%), Positives = 206/499 (41%), Gaps = 89/499 (17%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
E EDL + + K +LG+ L EL L++ +AQ R +R +QE EL+
Sbjct: 1147 EAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR-EQEVTELK 1205
Query: 105 RGL-------------------------------AARG-AEWEARAVELEGDVEALRAQL 132
+ L A RG WE + LE +V LRA+L
Sbjct: 1206 KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1265
Query: 133 GEQRSEQQDSGRERARALSELSEQNLRL---SQQLAQASQTEQELQRELDALRG---QCQ 186
++ +Q+ + R R +L E R + A+A++ Q Q EL+ + G + +
Sbjct: 1266 SSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1325
Query: 187 AQAL--------AGAELRTRLESLQGENQ---MLQSRRQDLEAQIRGLREEV-------E 228
++ + A+L E LQ E + L SR + +EA+ GLRE++ E
Sbjct: 1326 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE 1385
Query: 229 KGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDA 288
+ LQT +L RR + E + LE A L +R++E E +
Sbjct: 1386 RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE--TVDRL 1443
Query: 289 DVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRT 348
+ LQ EL + D +Q + +T K RK +L ++R
Sbjct: 1444 ERGRRRLQQELDDATMDLEQQR------QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERE 1497
Query: 349 SLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQ-KELRAQEDPGEALHSALSDR 407
E +E E L +L+ E Q REEL+RQ + LRA+ L + LS +
Sbjct: 1498 RAE----AEGREREARALSLTRALE--EEQEAREELERQNRALRAE------LEALLSSK 1545
Query: 408 DEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQD---DMQVVIGQQL 464
D+ V K++ +L R + + + LRA Q L EL A +D ++V + Q L
Sbjct: 1546 DD-VGKSVH---ELERACRVAEQAAND-LRA--QVTELEDELTAAEDAKLRLEVTV-QAL 1597
Query: 465 RSQRQKELSASASSSTPRR 483
++Q +++L + RR
Sbjct: 1598 KTQHERDLQGRDEAGEERR 1616
Score = 72.0 bits (175), Expect = 1e-12
Identities = 99/418 (23%), Positives = 177/418 (42%), Gaps = 43/418 (10%)
Query: 55 QQKEKDLLLAAELGKMLLERNEELRRQL---ETLSAQHLER-EERLQQE------NHELR 104
Q++E L A E + R E Q +T + LER RLQQE + E +
Sbjct: 1405 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1464
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRER-ARALSELSEQNLRLSQQ 163
R L + + + + +L + +A + E+R + GRER ARALS L++
Sbjct: 1465 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALS--------LTRA 1516
Query: 164 LAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGL 223
L + + +EL+R+ ALR + +A + ++ + L+ ++ + DL AQ+ L
Sbjct: 1517 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1576
Query: 224 REEVEKGEG---RLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELE 280
+E+ E RL+ T + L + +H +L+ R EAGE Q R +E+E
Sbjct: 1577 EDELTAAEDAKLRLEVTVQAL------KTQHERDLQ-GRDEAGEERRRQLAKQLRDAEVE 1629
Query: 281 EESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEI 340
+ + ++ A+ + +L L++ + G + + RK + E+
Sbjct: 1630 RDEERKQRTLAVAA-RKKLEGELEELKAQMASAGQGKEEAVK--QLRKMQAQMKELWREV 1686
Query: 341 LEPPKKRTSLSPAEILEEK-----EVEVAKLQDEISLQQAELQSLREELQRQKELRAQED 395
E R + EK E EV +LQ+E+ A R + Q+ ++ A E
Sbjct: 1687 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL----AASDRARRQAQQDRDEMADEV 1742
Query: 396 PGEALHSA--LSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEA 451
L A L ++ + + +L +L + L+ + + Q +LT EL A
Sbjct: 1743 ANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSA 1800
Score = 70.9 bits (172), Expect = 3e-12
Identities = 122/492 (24%), Positives = 198/492 (40%), Gaps = 92/492 (18%)
Query: 54 LQQKEKDLLLAAELGKMLLERNEELRRQLETLS------AQHLEREERLQQENHELRRGL 107
LQ + ++L EL + EL+ ++ L A+ L E L E E R L
Sbjct: 879 LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 938
Query: 108 AARGAEWEARAVELEGDV------------EALRAQLGEQRSEQQDSGRERARA------ 149
AAR E E ELE V E R Q Q E E AR
Sbjct: 939 AARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 998
Query: 150 -------------LSELSEQNLRLSQQ-------LAQASQ---TEQELQRELDALRGQCQ 186
L L +QN +LS++ LA+ S E+E + L+ LR + +
Sbjct: 999 VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1058
Query: 187 AQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRR 246
A A++ RL + Q L+ ++ L+ + L+E++ + + R + + L R
Sbjct: 1059 ATI---ADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ---LGR 1112
Query: 247 ERREHSLELERARSEAG---EALSALRRLQRRVSELEE------------ESRLQDADVS 291
+ E L RA E G + L +LR Q ++E +E E + +D
Sbjct: 1113 KEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEE 1172
Query: 292 AASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLS 351
+L+ EL +LD + Q + + T KT + + + L +
Sbjct: 1173 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1232
Query: 352 PAEILEEK-------EVEVAKLQDEISLQQAELQSLR------EELQRQKELRAQEDPGE 398
AE LE+ E L+ E+S +AEL SL+ E+ +R+ EL+ QE G
Sbjct: 1233 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR 1292
Query: 399 ALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQEL---EAWQDD 455
A D + A +A E +L R E +++S L A + + L++EL EA D
Sbjct: 1293 A-----GDGERARAEAAE---KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1344
Query: 456 MQVVIGQQLRSQ 467
Q ++ ++ R++
Sbjct: 1345 AQELLQEETRAK 1356
Score = 68.9 bits (167), Expect = 1e-11
Identities = 86/367 (23%), Positives = 162/367 (44%), Gaps = 44/367 (11%)
Query: 43 GPEEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHE 102
G E LA QL+ E + + + + ++L +LE L AQ + ++ +
Sbjct: 1612 GEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1671
Query: 103 LRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
LR+ +A+ EL +VE R R E RE + L L + LRL +
Sbjct: 1672 LRK--------MQAQMKELWREVEETRT----SREEIFSQNRESEKRLKGLEAEVLRLQE 1719
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+LA + + ++ Q++ D + A +A L + +L+ +RQ LE ++
Sbjct: 1720 ELAASDRARRQAQQDRDEM-----ADEVANGNL--------SKAAILEEKRQ-LEGRLGQ 1765
Query: 223 LREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEE 282
L EE+E+ + + ++ L + + EL RS + +A S ++L+R++ EL
Sbjct: 1766 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGR 1825
Query: 283 SRLQDADVSA------ASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSP 336
+DA A A+L+S+LA + + +Q R+ K K
Sbjct: 1826 LGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK-------- 1877
Query: 337 PEEILE-PPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQED 395
E +L+ ++R + + LE+ + V +L+ + L++AE ++ R + R++ R ED
Sbjct: 1878 -EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQ--LEEAEEEASRAQAGRRRLQRELED 1934
Query: 396 PGEALHS 402
E+ S
Sbjct: 1935 VTESAES 1941
Score = 68.6 bits (166), Expect = 1e-11
Identities = 96/452 (21%), Positives = 184/452 (40%), Gaps = 45/452 (9%)
Query: 48 EDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGL 107
+D+ + + E+ +A + L + EL +L L E +Q + R L
Sbjct: 1546 DDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDL 1605
Query: 108 AARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQA 167
R E R +L + + E+R ++ + R + EL E L Q+A A
Sbjct: 1606 QGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE----LKAQMASA 1661
Query: 168 SQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEV 227
Q ++E ++L ++ Q + E RT E + +N+ + R + LEA++ L+EE+
Sbjct: 1662 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1721
Query: 228 EKGE-GRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQ 286
+ R Q +++R E + E+ L R+L+ R+ +LEEE
Sbjct: 1722 AASDRARRQA--------QQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEE---- 1769
Query: 287 DADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEI---LEP 343
L+ E ++S D+ + ++ TT R S+ S +++ ++
Sbjct: 1770 --------LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQE 1821
Query: 344 PKKRTSLSPAEILEEKEVEVAKLQDEISLQQAEL-QSLREELQRQKELRAQEDPGEALHS 402
+ R A ++ +A L+ +++ + +L Q RE + K +R E + L
Sbjct: 1822 LRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAE---KRLKE 1878
Query: 403 ALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQ 462
+ +E A +L QL + +L L R+L EA ++ + G+
Sbjct: 1879 VVLQVEEERRVADQLRDQLEKGNLRVKQLKRQL-------------EEAEEEASRAQAGR 1925
Query: 463 QLRSQRQKELSASASSSTPRRAAPRFSLRLGP 494
+ + ++++ SA S R LR GP
Sbjct: 1926 RRLQRELEDVTESAESMNREVTTLRNRLRRGP 1957
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/373 (23%), Positives = 166/373 (44%), Gaps = 64/373 (17%)
Query: 115 EARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQEL 174
+ARA EL+ V+ L+ Q + E Q GR +++L E+ RL++QL + E EL
Sbjct: 880 QARAQELQ-KVQELQQQSAREVGELQ--GR-----VAQLEEERARLAEQL----RAEAEL 927
Query: 175 QRELDALRGQCQAQ----ALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKG 230
E + RG+ A+ L +EL R+ + ++ +Q+ ++ L+ I+ L +E
Sbjct: 928 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 987
Query: 231 EGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADV 290
EG Q L+LE+ +EA ++ + EE+ L +
Sbjct: 988 EGARQ----------------KLQLEKVTTEA------------KMKKFEEDLLLLEDQN 1019
Query: 291 SAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSL 350
S S + +L Q A+ + + K + + + + K R L
Sbjct: 1020 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL-KYEATIADMEDRLRKEEKGRQEL 1078
Query: 351 SPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKE-----LRAQEDPGEALHSALS 405
++ + E ++LQ+++ QQ + LR +L R++E L ED G A L
Sbjct: 1079 E--KLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLK 1136
Query: 406 DRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIG---- 461
EA + +L + LE + ++R +A +Q+ L +ELEA + +++ +
Sbjct: 1137 SLREA-----QAALAEAQEDLESERVAR--TKAEKQRRDLGEELEALRGELEDTLDSTNA 1189
Query: 462 -QQLRSQRQKELS 473
Q+LRS+R++E++
Sbjct: 1190 QQELRSKREQEVT 1202
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 92.8 bits (229), Expect = 7e-19
Identities = 128/496 (25%), Positives = 210/496 (42%), Gaps = 65/496 (13%)
Query: 48 EDLALQLQQ-----KEKDLL--LAAELGKMLLERNEE------LRRQLETLSAQ---HLE 91
EDL L Q KE+ LL AE E E+ LR + E A L
Sbjct: 1002 EDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLR 1061
Query: 92 REERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQ-------DSGR 144
+EE+ +QE +L+R L +E + + VE + E LRAQLG + E Q D G
Sbjct: 1062 KEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGG 1121
Query: 145 ERARALSELSEQNLRLSQ-----QLAQASQTEQELQR-----ELDALRGQCQ---AQALA 191
RA+ L L E L++ + + ++T+ E QR EL+ALRG+ + A
Sbjct: 1122 ARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA 1181
Query: 192 GAELRTRLESLQGE-NQMLQSRRQDLEAQIRGLR--------------EEVEKGEGRLQT 236
ELR++ E E + L+ + EA ++ LR E+ +G+G +
Sbjct: 1182 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEK 1241
Query: 237 THEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQ 296
T L L E E EL ++ E RRL+ ++ E+ + R D + + A
Sbjct: 1242 TR---LALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEV--QGRAGDGERARAEAA 1296
Query: 297 SELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEIL 356
+L + + + GA ++ T R K ++ Q +E+L+ + R L+ +
Sbjct: 1297 EKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ-EETRAKLALGSRV 1355
Query: 357 EEKEVEVAKLQDEISLQQAELQSLREELQ-RQKEL----RAQEDPGEALHSALSDRDEAV 411
E E A L++++ + A + ELQ Q +L R QE+ AL + R A
Sbjct: 1356 RAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAA 1415
Query: 412 NKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKE 471
+A L+ +L + D L R R ++ T +LE Q+V + + ++ +
Sbjct: 1416 REAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE---QQRQLVSTLEKKQRKFDQ 1472
Query: 472 LSASASSSTPRRAAPR 487
L A ++ R R
Sbjct: 1473 LLAEEKAAVLRAVEER 1488
Score = 75.1 bits (183), Expect = 1e-13
Identities = 127/499 (25%), Positives = 206/499 (41%), Gaps = 89/499 (17%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
E EDL + + K +LG+ L EL L++ +AQ R +R +QE EL+
Sbjct: 1139 EAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR-EQEVTELK 1197
Query: 105 RGL-------------------------------AARG-AEWEARAVELEGDVEALRAQL 132
+ L A RG WE + LE +V LRA+L
Sbjct: 1198 KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1257
Query: 133 GEQRSEQQDSGRERARALSELSEQNLRL---SQQLAQASQTEQELQRELDALRG---QCQ 186
++ +Q+ + R R +L E R + A+A++ Q Q EL+ + G + +
Sbjct: 1258 SSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1317
Query: 187 AQAL--------AGAELRTRLESLQGENQ---MLQSRRQDLEAQIRGLREEV-------E 228
++ + A+L E LQ E + L SR + +EA+ GLRE++ E
Sbjct: 1318 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE 1377
Query: 229 KGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDA 288
+ LQT +L RR + E + LE A L +R++E E +
Sbjct: 1378 RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE--TVDRL 1435
Query: 289 DVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRT 348
+ LQ EL + D +Q + +T K RK +L ++R
Sbjct: 1436 ERGRRRLQQELDDATMDLEQQR------QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERE 1489
Query: 349 SLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQ-KELRAQEDPGEALHSALSDR 407
E +E E L +L+ E Q REEL+RQ + LRA+ L + LS +
Sbjct: 1490 RAE----AEGREREARALSLTRALE--EEQEAREELERQNRALRAE------LEALLSSK 1537
Query: 408 DEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQD---DMQVVIGQQL 464
D+ V K++ +L R + + + LRA Q L EL A +D ++V + Q L
Sbjct: 1538 DD-VGKSVH---ELERACRVAEQAAND-LRA--QVTELEDELTAAEDAKLRLEVTV-QAL 1589
Query: 465 RSQRQKELSASASSSTPRR 483
++Q +++L + RR
Sbjct: 1590 KTQHERDLQGRDEAGEERR 1608
Score = 72.0 bits (175), Expect = 1e-12
Identities = 99/418 (23%), Positives = 177/418 (42%), Gaps = 43/418 (10%)
Query: 55 QQKEKDLLLAAELGKMLLERNEELRRQL---ETLSAQHLER-EERLQQE------NHELR 104
Q++E L A E + R E Q +T + LER RLQQE + E +
Sbjct: 1397 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1456
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRER-ARALSELSEQNLRLSQQ 163
R L + + + + +L + +A + E+R + GRER ARALS L++
Sbjct: 1457 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALS--------LTRA 1508
Query: 164 LAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGL 223
L + + +EL+R+ ALR + +A + ++ + L+ ++ + DL AQ+ L
Sbjct: 1509 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1568
Query: 224 REEVEKGEG---RLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELE 280
+E+ E RL+ T + L + +H +L+ R EAGE Q R +E+E
Sbjct: 1569 EDELTAAEDAKLRLEVTVQAL------KTQHERDLQ-GRDEAGEERRRQLAKQLRDAEVE 1621
Query: 281 EESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEI 340
+ + ++ A+ + +L L++ + G + + RK + E+
Sbjct: 1622 RDEERKQRTLAVAA-RKKLEGELEELKAQMASAGQGKEEAVK--QLRKMQAQMKELWREV 1678
Query: 341 LEPPKKRTSLSPAEILEEK-----EVEVAKLQDEISLQQAELQSLREELQRQKELRAQED 395
E R + EK E EV +LQ+E+ A R + Q+ ++ A E
Sbjct: 1679 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL----AASDRARRQAQQDRDEMADEV 1734
Query: 396 PGEALHSA--LSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEA 451
L A L ++ + + +L +L + L+ + + Q +LT EL A
Sbjct: 1735 ANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSA 1792
Score = 70.9 bits (172), Expect = 3e-12
Identities = 122/492 (24%), Positives = 198/492 (40%), Gaps = 92/492 (18%)
Query: 54 LQQKEKDLLLAAELGKMLLERNEELRRQLETLS------AQHLEREERLQQENHELRRGL 107
LQ + ++L EL + EL+ ++ L A+ L E L E E R L
Sbjct: 871 LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 930
Query: 108 AARGAEWEARAVELEGDV------------EALRAQLGEQRSEQQDSGRERARA------ 149
AAR E E ELE V E R Q Q E E AR
Sbjct: 931 AARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 990
Query: 150 -------------LSELSEQNLRLSQQ-------LAQASQ---TEQELQRELDALRGQCQ 186
L L +QN +LS++ LA+ S E+E + L+ LR + +
Sbjct: 991 VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1050
Query: 187 AQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRR 246
A A++ RL + Q L+ ++ L+ + L+E++ + + R + + L R
Sbjct: 1051 ATI---ADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ---LGR 1104
Query: 247 ERREHSLELERARSEAG---EALSALRRLQRRVSELEE------------ESRLQDADVS 291
+ E L RA E G + L +LR Q ++E +E E + +D
Sbjct: 1105 KEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEE 1164
Query: 292 AASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLS 351
+L+ EL +LD + Q + + T KT + + + L +
Sbjct: 1165 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1224
Query: 352 PAEILEEK-------EVEVAKLQDEISLQQAELQSLR------EELQRQKELRAQEDPGE 398
AE LE+ E L+ E+S +AEL SL+ E+ +R+ EL+ QE G
Sbjct: 1225 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR 1284
Query: 399 ALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQEL---EAWQDD 455
A D + A +A E +L R E +++S L A + + L++EL EA D
Sbjct: 1285 A-----GDGERARAEAAE---KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1336
Query: 456 MQVVIGQQLRSQ 467
Q ++ ++ R++
Sbjct: 1337 AQELLQEETRAK 1348
Score = 68.9 bits (167), Expect = 1e-11
Identities = 86/367 (23%), Positives = 162/367 (44%), Gaps = 44/367 (11%)
Query: 43 GPEEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHE 102
G E LA QL+ E + + + + ++L +LE L AQ + ++ +
Sbjct: 1604 GEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1663
Query: 103 LRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
LR+ +A+ EL +VE R R E RE + L L + LRL +
Sbjct: 1664 LRK--------MQAQMKELWREVEETRT----SREEIFSQNRESEKRLKGLEAEVLRLQE 1711
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+LA + + ++ Q++ D + A +A L + +L+ +RQ LE ++
Sbjct: 1712 ELAASDRARRQAQQDRDEM-----ADEVANGNL--------SKAAILEEKRQ-LEGRLGQ 1757
Query: 223 LREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEE 282
L EE+E+ + + ++ L + + EL RS + +A S ++L+R++ EL
Sbjct: 1758 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGR 1817
Query: 283 SRLQDADVSA------ASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSP 336
+DA A A+L+S+LA + + +Q R+ K K
Sbjct: 1818 LGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK-------- 1869
Query: 337 PEEILE-PPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQED 395
E +L+ ++R + + LE+ + V +L+ + L++AE ++ R + R++ R ED
Sbjct: 1870 -EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQ--LEEAEEEASRAQAGRRRLQRELED 1926
Query: 396 PGEALHS 402
E+ S
Sbjct: 1927 VTESAES 1933
Score = 68.6 bits (166), Expect = 1e-11
Identities = 96/452 (21%), Positives = 184/452 (40%), Gaps = 45/452 (9%)
Query: 48 EDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGL 107
+D+ + + E+ +A + L + EL +L L E +Q + R L
Sbjct: 1538 DDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDL 1597
Query: 108 AARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQA 167
R E R +L + + E+R ++ + R + EL E L Q+A A
Sbjct: 1598 QGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE----LKAQMASA 1653
Query: 168 SQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEV 227
Q ++E ++L ++ Q + E RT E + +N+ + R + LEA++ L+EE+
Sbjct: 1654 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1713
Query: 228 EKGE-GRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQ 286
+ R Q +++R E + E+ L R+L+ R+ +LEEE
Sbjct: 1714 AASDRARRQA--------QQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEE---- 1761
Query: 287 DADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEI---LEP 343
L+ E ++S D+ + ++ TT R S+ S +++ ++
Sbjct: 1762 --------LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQE 1813
Query: 344 PKKRTSLSPAEILEEKEVEVAKLQDEISLQQAEL-QSLREELQRQKELRAQEDPGEALHS 402
+ R A ++ +A L+ +++ + +L Q RE + K +R E + L
Sbjct: 1814 LRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAE---KRLKE 1870
Query: 403 ALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQ 462
+ +E A +L QL + +L L R+L EA ++ + G+
Sbjct: 1871 VVLQVEEERRVADQLRDQLEKGNLRVKQLKRQL-------------EEAEEEASRAQAGR 1917
Query: 463 QLRSQRQKELSASASSSTPRRAAPRFSLRLGP 494
+ + ++++ SA S R LR GP
Sbjct: 1918 RRLQRELEDVTESAESMNREVTTLRNRLRRGP 1949
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/373 (23%), Positives = 166/373 (44%), Gaps = 64/373 (17%)
Query: 115 EARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQEL 174
+ARA EL+ V+ L+ Q + E Q GR +++L E+ RL++QL + E EL
Sbjct: 872 QARAQELQ-KVQELQQQSAREVGELQ--GR-----VAQLEEERARLAEQL----RAEAEL 919
Query: 175 QRELDALRGQCQAQ----ALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKG 230
E + RG+ A+ L +EL R+ + ++ +Q+ ++ L+ I+ L +E
Sbjct: 920 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 979
Query: 231 EGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADV 290
EG Q L+LE+ +EA ++ + EE+ L +
Sbjct: 980 EGARQ----------------KLQLEKVTTEA------------KMKKFEEDLLLLEDQN 1011
Query: 291 SAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSL 350
S S + +L Q A+ + + K + + + + K R L
Sbjct: 1012 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL-KYEATIADMEDRLRKEEKGRQEL 1070
Query: 351 SPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKE-----LRAQEDPGEALHSALS 405
++ + E ++LQ+++ QQ + LR +L R++E L ED G A L
Sbjct: 1071 E--KLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLK 1128
Query: 406 DRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIG---- 461
EA + +L + LE + ++R +A +Q+ L +ELEA + +++ +
Sbjct: 1129 SLREA-----QAALAEAQEDLESERVAR--TKAEKQRRDLGEELEALRGELEDTLDSTNA 1181
Query: 462 -QQLRSQRQKELS 473
Q+LRS+R++E++
Sbjct: 1182 QQELRSKREQEVT 1194
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 92.8 bits (229), Expect = 7e-19
Identities = 128/496 (25%), Positives = 210/496 (42%), Gaps = 65/496 (13%)
Query: 48 EDLALQLQQ-----KEKDLL--LAAELGKMLLERNEE------LRRQLETLSAQ---HLE 91
EDL L Q KE+ LL AE E E+ LR + E A L
Sbjct: 1043 EDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLR 1102
Query: 92 REERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQ-------DSGR 144
+EE+ +QE +L+R L +E + + VE + E LRAQLG + E Q D G
Sbjct: 1103 KEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGG 1162
Query: 145 ERARALSELSEQNLRLSQ-----QLAQASQTEQELQR-----ELDALRGQCQ---AQALA 191
RA+ L L E L++ + + ++T+ E QR EL+ALRG+ + A
Sbjct: 1163 ARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA 1222
Query: 192 GAELRTRLESLQGE-NQMLQSRRQDLEAQIRGLR--------------EEVEKGEGRLQT 236
ELR++ E E + L+ + EA ++ LR E+ +G+G +
Sbjct: 1223 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEK 1282
Query: 237 THEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQ 296
T L L E E EL ++ E RRL+ ++ E+ + R D + + A
Sbjct: 1283 TR---LALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEV--QGRAGDGERARAEAA 1337
Query: 297 SELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEIL 356
+L + + + GA ++ T R K ++ Q +E+L+ + R L+ +
Sbjct: 1338 EKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ-EETRAKLALGSRV 1396
Query: 357 EEKEVEVAKLQDEISLQQAELQSLREELQ-RQKEL----RAQEDPGEALHSALSDRDEAV 411
E E A L++++ + A + ELQ Q +L R QE+ AL + R A
Sbjct: 1397 RAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAA 1456
Query: 412 NKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKE 471
+A L+ +L + D L R R ++ T +LE Q+V + + ++ +
Sbjct: 1457 REAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE---QQRQLVSTLEKKQRKFDQ 1513
Query: 472 LSASASSSTPRRAAPR 487
L A ++ R R
Sbjct: 1514 LLAEEKAAVLRAVEER 1529
Score = 75.1 bits (183), Expect = 1e-13
Identities = 127/499 (25%), Positives = 206/499 (41%), Gaps = 89/499 (17%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
E EDL + + K +LG+ L EL L++ +AQ R +R +QE EL+
Sbjct: 1180 EAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR-EQEVTELK 1238
Query: 105 RGL-------------------------------AARG-AEWEARAVELEGDVEALRAQL 132
+ L A RG WE + LE +V LRA+L
Sbjct: 1239 KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1298
Query: 133 GEQRSEQQDSGRERARALSELSEQNLRL---SQQLAQASQTEQELQRELDALRG---QCQ 186
++ +Q+ + R R +L E R + A+A++ Q Q EL+ + G + +
Sbjct: 1299 SSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1358
Query: 187 AQAL--------AGAELRTRLESLQGENQ---MLQSRRQDLEAQIRGLREEV-------E 228
++ + A+L E LQ E + L SR + +EA+ GLRE++ E
Sbjct: 1359 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE 1418
Query: 229 KGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDA 288
+ LQT +L RR + E + LE A L +R++E E +
Sbjct: 1419 RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE--TVDRL 1476
Query: 289 DVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRT 348
+ LQ EL + D +Q + +T K RK +L ++R
Sbjct: 1477 ERGRRRLQQELDDATMDLEQQR------QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERE 1530
Query: 349 SLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQ-KELRAQEDPGEALHSALSDR 407
E +E E L +L+ E Q REEL+RQ + LRA+ L + LS +
Sbjct: 1531 RAE----AEGREREARALSLTRALE--EEQEAREELERQNRALRAE------LEALLSSK 1578
Query: 408 DEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQD---DMQVVIGQQL 464
D+ V K++ +L R + + + LRA Q L EL A +D ++V + Q L
Sbjct: 1579 DD-VGKSVH---ELERACRVAEQAAND-LRA--QVTELEDELTAAEDAKLRLEVTV-QAL 1630
Query: 465 RSQRQKELSASASSSTPRR 483
++Q +++L + RR
Sbjct: 1631 KTQHERDLQGRDEAGEERR 1649
Score = 72.0 bits (175), Expect = 1e-12
Identities = 99/418 (23%), Positives = 177/418 (42%), Gaps = 43/418 (10%)
Query: 55 QQKEKDLLLAAELGKMLLERNEELRRQL---ETLSAQHLER-EERLQQE------NHELR 104
Q++E L A E + R E Q +T + LER RLQQE + E +
Sbjct: 1438 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1497
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRER-ARALSELSEQNLRLSQQ 163
R L + + + + +L + +A + E+R + GRER ARALS L++
Sbjct: 1498 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALS--------LTRA 1549
Query: 164 LAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGL 223
L + + +EL+R+ ALR + +A + ++ + L+ ++ + DL AQ+ L
Sbjct: 1550 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1609
Query: 224 REEVEKGEG---RLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELE 280
+E+ E RL+ T + L + +H +L+ R EAGE Q R +E+E
Sbjct: 1610 EDELTAAEDAKLRLEVTVQAL------KTQHERDLQ-GRDEAGEERRRQLAKQLRDAEVE 1662
Query: 281 EESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEI 340
+ + ++ A+ + +L L++ + G + + RK + E+
Sbjct: 1663 RDEERKQRTLAVAA-RKKLEGELEELKAQMASAGQGKEEAVK--QLRKMQAQMKELWREV 1719
Query: 341 LEPPKKRTSLSPAEILEEK-----EVEVAKLQDEISLQQAELQSLREELQRQKELRAQED 395
E R + EK E EV +LQ+E+ A R + Q+ ++ A E
Sbjct: 1720 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL----AASDRARRQAQQDRDEMADEV 1775
Query: 396 PGEALHSA--LSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEA 451
L A L ++ + + +L +L + L+ + + Q +LT EL A
Sbjct: 1776 ANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSA 1833
Score = 70.9 bits (172), Expect = 3e-12
Identities = 122/492 (24%), Positives = 198/492 (40%), Gaps = 92/492 (18%)
Query: 54 LQQKEKDLLLAAELGKMLLERNEELRRQLETLS------AQHLEREERLQQENHELRRGL 107
LQ + ++L EL + EL+ ++ L A+ L E L E E R L
Sbjct: 912 LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 971
Query: 108 AARGAEWEARAVELEGDV------------EALRAQLGEQRSEQQDSGRERARA------ 149
AAR E E ELE V E R Q Q E E AR
Sbjct: 972 AARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 1031
Query: 150 -------------LSELSEQNLRLSQQ-------LAQASQ---TEQELQRELDALRGQCQ 186
L L +QN +LS++ LA+ S E+E + L+ LR + +
Sbjct: 1032 VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1091
Query: 187 AQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRR 246
A A++ RL + Q L+ ++ L+ + L+E++ + + R + + L R
Sbjct: 1092 ATI---ADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ---LGR 1145
Query: 247 ERREHSLELERARSEAG---EALSALRRLQRRVSELEE------------ESRLQDADVS 291
+ E L RA E G + L +LR Q ++E +E E + +D
Sbjct: 1146 KEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEE 1205
Query: 292 AASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLS 351
+L+ EL +LD + Q + + T KT + + + L +
Sbjct: 1206 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1265
Query: 352 PAEILEEK-------EVEVAKLQDEISLQQAELQSLR------EELQRQKELRAQEDPGE 398
AE LE+ E L+ E+S +AEL SL+ E+ +R+ EL+ QE G
Sbjct: 1266 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR 1325
Query: 399 ALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQEL---EAWQDD 455
A D + A +A E +L R E +++S L A + + L++EL EA D
Sbjct: 1326 A-----GDGERARAEAAE---KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1377
Query: 456 MQVVIGQQLRSQ 467
Q ++ ++ R++
Sbjct: 1378 AQELLQEETRAK 1389
Score = 68.9 bits (167), Expect = 1e-11
Identities = 86/367 (23%), Positives = 162/367 (44%), Gaps = 44/367 (11%)
Query: 43 GPEEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHE 102
G E LA QL+ E + + + + ++L +LE L AQ + ++ +
Sbjct: 1645 GEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1704
Query: 103 LRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
LR+ +A+ EL +VE R R E RE + L L + LRL +
Sbjct: 1705 LRK--------MQAQMKELWREVEETRT----SREEIFSQNRESEKRLKGLEAEVLRLQE 1752
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+LA + + ++ Q++ D + A +A L + +L+ +RQ LE ++
Sbjct: 1753 ELAASDRARRQAQQDRDEM-----ADEVANGNL--------SKAAILEEKRQ-LEGRLGQ 1798
Query: 223 LREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEE 282
L EE+E+ + + ++ L + + EL RS + +A S ++L+R++ EL
Sbjct: 1799 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGR 1858
Query: 283 SRLQDADVSA------ASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSP 336
+DA A A+L+S+LA + + +Q R+ K K
Sbjct: 1859 LGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK-------- 1910
Query: 337 PEEILE-PPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQED 395
E +L+ ++R + + LE+ + V +L+ + L++AE ++ R + R++ R ED
Sbjct: 1911 -EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQ--LEEAEEEASRAQAGRRRLQRELED 1967
Query: 396 PGEALHS 402
E+ S
Sbjct: 1968 VTESAES 1974
Score = 68.6 bits (166), Expect = 1e-11
Identities = 96/452 (21%), Positives = 184/452 (40%), Gaps = 45/452 (9%)
Query: 48 EDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGL 107
+D+ + + E+ +A + L + EL +L L E +Q + R L
Sbjct: 1579 DDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDL 1638
Query: 108 AARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQA 167
R E R +L + + E+R ++ + R + EL E L Q+A A
Sbjct: 1639 QGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE----LKAQMASA 1694
Query: 168 SQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEV 227
Q ++E ++L ++ Q + E RT E + +N+ + R + LEA++ L+EE+
Sbjct: 1695 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1754
Query: 228 EKGE-GRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQ 286
+ R Q +++R E + E+ L R+L+ R+ +LEEE
Sbjct: 1755 AASDRARRQA--------QQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEE---- 1802
Query: 287 DADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEI---LEP 343
L+ E ++S D+ + ++ TT R S+ S +++ ++
Sbjct: 1803 --------LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQE 1854
Query: 344 PKKRTSLSPAEILEEKEVEVAKLQDEISLQQAEL-QSLREELQRQKELRAQEDPGEALHS 402
+ R A ++ +A L+ +++ + +L Q RE + K +R E + L
Sbjct: 1855 LRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAE---KRLKE 1911
Query: 403 ALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQ 462
+ +E A +L QL + +L L R+L EA ++ + G+
Sbjct: 1912 VVLQVEEERRVADQLRDQLEKGNLRVKQLKRQL-------------EEAEEEASRAQAGR 1958
Query: 463 QLRSQRQKELSASASSSTPRRAAPRFSLRLGP 494
+ + ++++ SA S R LR GP
Sbjct: 1959 RRLQRELEDVTESAESMNREVTTLRNRLRRGP 1990
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/373 (23%), Positives = 166/373 (44%), Gaps = 64/373 (17%)
Query: 115 EARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQEL 174
+ARA EL+ V+ L+ Q + E Q GR +++L E+ RL++QL + E EL
Sbjct: 913 QARAQELQ-KVQELQQQSAREVGELQ--GR-----VAQLEEERARLAEQL----RAEAEL 960
Query: 175 QRELDALRGQCQAQ----ALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKG 230
E + RG+ A+ L +EL R+ + ++ +Q+ ++ L+ I+ L +E
Sbjct: 961 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 1020
Query: 231 EGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADV 290
EG Q L+LE+ +EA ++ + EE+ L +
Sbjct: 1021 EGARQ----------------KLQLEKVTTEA------------KMKKFEEDLLLLEDQN 1052
Query: 291 SAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSL 350
S S + +L Q A+ + + K + + + + K R L
Sbjct: 1053 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL-KYEATIADMEDRLRKEEKGRQEL 1111
Query: 351 SPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKE-----LRAQEDPGEALHSALS 405
++ + E ++LQ+++ QQ + LR +L R++E L ED G A L
Sbjct: 1112 E--KLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLK 1169
Query: 406 DRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIG---- 461
EA + +L + LE + ++R +A +Q+ L +ELEA + +++ +
Sbjct: 1170 SLREA-----QAALAEAQEDLESERVAR--TKAEKQRRDLGEELEALRGELEDTLDSTNA 1222
Query: 462 -QQLRSQRQKELS 473
Q+LRS+R++E++
Sbjct: 1223 QQELRSKREQEVT 1235
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 91.3 bits (225), Expect = 2e-18
Identities = 119/467 (25%), Positives = 204/467 (43%), Gaps = 54/467 (11%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
+E DLALQLQ ++ +L A E +L++ +L +++ LS ERL+ E E+
Sbjct: 931 QEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELS-------ERLEDE-EEVN 982
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
LAAR + E EL+ D++ L+ L + E+Q + + + L+E+ L + +
Sbjct: 983 ADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENK----VKNLTEEMAALDESV 1038
Query: 165 AQASQTEQELQRELDALRGQCQAQ-----ALAGAELRTRLE------SLQGENQM---LQ 210
A+ ++ ++ LQ G QA+ AL A+LR + SL+ E ++ +
Sbjct: 1039 ARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTE 1098
Query: 211 SRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALR 270
++ LE ++ +E V Q E+L E + SL +E + + ++
Sbjct: 1099 RAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIK 1158
Query: 271 RLQRRVSELEEESRLQDADVSAASLQ-SELAHSLDDGDQGQGADAPGDTPTTRSPKTRKA 329
LQ R ELEEE + A + Q +E A L+ + + + G + RK
Sbjct: 1159 ELQARAEELEEELEAERAARARVEKQRAEAARELE--ELSERLEEAGGASAGQREGCRKR 1216
Query: 330 SSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQK- 388
+ E+ E + + A L K+ E A E+ Q LQ +R++L+++K
Sbjct: 1217 EAELGRLRRELEEAALRHEATVAA--LRRKQAEGAA---ELGEQVDSLQRVRQKLEKEKS 1271
Query: 389 ELRAQED--------------PGEALHSALSDR-DEAVNKALELSLQLNRVSLERDSL-- 431
ELR + D E L D+ EA K EL QL S +R L
Sbjct: 1272 ELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQT 1331
Query: 432 -SRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASAS 477
S EL R + +K L +L + + ++LR Q ++E A ++
Sbjct: 1332 ESGELSRLLEEKECLISQLSRGK-ALAAQSLEELRRQLEEESKAKSA 1377
Score = 78.6 bits (192), Expect = 1e-14
Identities = 111/429 (25%), Positives = 182/429 (42%), Gaps = 44/429 (10%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERN-EELRRQLETLSAQHLEREERLQQENHELR 104
E +L+ L++KE L+ GK L ++ EELRRQLE S +Q H+
Sbjct: 1332 ESGELSRLLEEKEC-LISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCD 1390
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
E EA+A EL+ + A++ + RS+ + +R EL E +L+ +L
Sbjct: 1391 LLREQHEEEAEAQA-ELQRLLSKANAEVAQWRSKYEADAIQRTE---ELEEAKKKLALRL 1446
Query: 165 AQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLR 224
QE + ++A +C + A L+T E + E + S L+ + R L
Sbjct: 1447 -------QEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLE 1499
Query: 225 EEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEE-S 283
+E+ + + EL +RE R EL R R EAL AL L+R L+EE S
Sbjct: 1500 RALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEIS 1559
Query: 284 RLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEP 343
L D SL + L+ KT+KA + S + LE
Sbjct: 1560 DLTD----QVSLSGKSIQELE--------------------KTKKALEGEKSEIQAALEE 1595
Query: 344 PKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSA 403
+ L + L ++E+++++ E+ + AE L+R + RA E +L +
Sbjct: 1596 AEGALELEETKTL-RIQLELSQVKAEVDRKLAEKDEECANLRRNHQ-RAVESLQASLDAE 1653
Query: 404 LSDRDEAVNKALELSLQLNRVSLERDSLSR---ELLRAIRQKVALTQELEAWQDDMQVVI 460
R+EA+ ++ LN + L+ +R E A R A +E +A +D+ Q +
Sbjct: 1654 TRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQ-RL 1712
Query: 461 GQQLRSQRQ 469
+L Q Q
Sbjct: 1713 AAELHEQAQ 1721
Score = 71.6 bits (174), Expect = 2e-12
Identities = 96/430 (22%), Positives = 176/430 (40%), Gaps = 30/430 (6%)
Query: 48 EDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGL 107
+DL L L + EK+ K L E L + L+ + +E QQ +L+
Sbjct: 1004 DDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEE 1063
Query: 108 AARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQ-LAQ 166
A +A+ + LE VE L L +++ + D+ R + + E +L+L+Q+ +A
Sbjct: 1064 DRVSALTKAK-LRLEQQVEDLECSLEQEKKLRMDTERAKRKL-----EGDLKLTQESVAD 1117
Query: 167 ASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREE 226
A+Q +Q+L+ +L + ++L R+E Q +Q + ++L+A+ L EE
Sbjct: 1118 AAQDKQQLEEKLKKKDSEL-------SQLSLRVEDEQLLGAQMQKKIKELQARAEELEEE 1170
Query: 227 VEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQ 286
+E ++ RE E S LE A + R+ + + L E
Sbjct: 1171 LEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRE---- 1226
Query: 287 DADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKK 346
+ A+L+ E + Q +GA G+ + +K + E+ +
Sbjct: 1227 ---LEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAAN 1283
Query: 347 RTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSD 406
+L+ A+ EK +D++S + +++ L+ +L R + S L +
Sbjct: 1284 VETLTRAKASAEKLCRT--YEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLE 1341
Query: 407 RDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRS 466
E + L L SLE L R+L + K AL ++A + D + LR
Sbjct: 1342 EKECLISQLSRGKALAAQSLE--ELRRQLEEESKAKSALAHAVQALRHDCDL-----LRE 1394
Query: 467 QRQKELSASA 476
Q ++E A A
Sbjct: 1395 QHEEEAEAQA 1404
Score = 61.2 bits (147), Expect = 2e-09
Identities = 80/307 (26%), Positives = 130/307 (42%), Gaps = 47/307 (15%)
Query: 43 GPEEPEDLALQLQQKEKDL-----LLAAELGKM--LLERNEELRRQLETLSAQHLEREER 95
G +E + LA +L ++ + L LLAAEL ++ LE+ E RR E + ER
Sbjct: 1705 GRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNL 1764
Query: 96 LQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSE 155
L +N GL + + EA +L G+VE + E + + + + A EL +
Sbjct: 1765 LHSQN----TGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKK 1820
Query: 156 QNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQD 215
+ S L + +T ++ REL A + + AL G G+ Q+ Q
Sbjct: 1821 EQ-DTSAHLERMKKTLEQTVRELQARLEEAEQAALRG-----------GKKQV-----QK 1863
Query: 216 LEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRR 275
LEA++R L E++ Q H E L + R+H ++ +A E L R+Q
Sbjct: 1864 LEAKVRELEAELDAE----QKKHAEAL---KGVRKHERRVKELAYQAEEDRKNLARMQDL 1916
Query: 276 VSELEE---------ESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKT 326
V +L+ E Q A+ + A + + H LDD + + AD +T
Sbjct: 1917 VDKLQSKVKSYKRQFEEAEQQANTNLAKYR-KAQHELDDAE--ERADMAETQANKLRART 1973
Query: 327 RKASSPQ 333
R A P+
Sbjct: 1974 RDALGPK 1980
Score = 55.5 bits (132), Expect = 1e-07
Identities = 84/360 (23%), Positives = 142/360 (39%), Gaps = 49/360 (13%)
Query: 51 ALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAAR 110
AL+ ++ E L G + LE + LR QLE L Q E+ R LA +
Sbjct: 1581 ALEGEKSEIQAALEEAEGALELEETKTLRIQLE------------LSQVKAEVDRKLAEK 1628
Query: 111 GAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQT 170
E + VE+L+A L + + ++ R + + +L++ L+L QA+
Sbjct: 1629 DEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAT-- 1686
Query: 171 EQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKG 230
E Q ++ Q + + E + L + Q L+ R L A++ LR +E+G
Sbjct: 1687 --EAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQG 1744
Query: 231 EGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSEL----------- 279
E + +ELL E + L S+ L+ ++L+ +++L
Sbjct: 1745 ERSRRLAEQELL-------EATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQER 1797
Query: 280 -EEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPE 338
E E + + A AA + EL D R KT + + +
Sbjct: 1798 REAEEKAKKAITDAAMMAEELKKEQDT-----------SAHLERMKKTLEQTVRELQARL 1846
Query: 339 EILEPPKKRTSLSPAEILEEKEVEV-AKLQDEISLQQAELQSLREELQRQKEL--RAQED 395
E E R + LE K E+ A+L E L+ +R+ +R KEL +A+ED
Sbjct: 1847 EEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEED 1906
Score = 43.5 bits (101), Expect = 5e-04
Identities = 68/302 (22%), Positives = 130/302 (43%), Gaps = 31/302 (10%)
Query: 193 AELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHS 252
A LR L L+G +++RQ+LE + + EK + LQ E+ L E R H
Sbjct: 899 AALRAELRGLRGALAAAEAKRQELEETHVSITQ--EKNDLALQLQAEQDNLADAEERCHL 956
Query: 253 L-----ELERARSEAGEAL-----------SALRRLQRRVSELEEESRLQDADVSAASLQ 296
L +LE E E L + R+L+ +EL+++ + D ++ A +
Sbjct: 957 LIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKD--IDDLKLTLAKAE 1014
Query: 297 SELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTS-LSPAEI 355
E + + A D R K +KA L+ + R S L+ A++
Sbjct: 1015 KEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKL 1074
Query: 356 LEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKAL 415
E++VE E SL+Q + + E ++K + E++ A D+ + K
Sbjct: 1075 RLEQQVE----DLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLK 1130
Query: 416 ELSLQLNRVSL---ERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKEL 472
+ +L+++SL + L ++ + I++ A +ELE ++++ + R ++Q+
Sbjct: 1131 KKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELE---EELEAERAARARVEKQRAE 1187
Query: 473 SA 474
+A
Sbjct: 1188 AA 1189
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 90.1 bits (222), Expect = 4e-18
Identities = 103/470 (21%), Positives = 201/470 (42%), Gaps = 40/470 (8%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
+E DL LQLQ +++ L E + L++ +L +++ LS + +E EE + E
Sbjct: 894 QEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELS-ERVEEEEEINSE----- 947
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
L ARG + E EL+ +++ L L + E++ + + E+ N +S+
Sbjct: 948 --LTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLN 1005
Query: 165 AQASQTEQELQRELDALRGQ---CQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIR 221
A ++ Q+ LD L + + + A +L +++ L+G + + R + E ++
Sbjct: 1006 RAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELH 1065
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEE 281
L ++ ++ L E R+ LEL + S+ + +LQ+ V EL+
Sbjct: 1066 KLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQT 1125
Query: 282 E-----SRLQDADVSAASLQSELAHSLDD-GDQGQGADAPGDTPTTRSPKTRKASSPQPS 335
+ +L+ + A ++ E A D D + + G + + T+K +
Sbjct: 1126 QIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQK 1185
Query: 336 PPEEILEPP----------KKRTSLSPAEI---LEEKEVEVAKLQDEISLQQAELQSLRE 382
++ E KKR + S AE+ +E + KL+ + S Q E+ L
Sbjct: 1186 LHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLT 1245
Query: 383 ELQRQKELRAQEDP-----GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLR 437
+++ +A + E LH A + D+ A +L+ Q ++ E S E LR
Sbjct: 1246 RVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSE----SGEFLR 1301
Query: 438 AIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPR 487
+ +K AL +L + + I + LR Q +KE + ++ + + A R
Sbjct: 1302 RLEEKEALINQLSREKSNFTRQI-EDLRGQLEKETKSQSALAHALQKAQR 1350
Score = 66.2 bits (160), Expect = 7e-11
Identities = 70/282 (24%), Positives = 134/282 (47%), Gaps = 36/282 (12%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREE--------RL 96
EE +L Q+++ K+L ++ K++ E E++ LE LER E L
Sbjct: 1519 EEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGA-LERNESKILHFQLEL 1577
Query: 97 QQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQ 156
+ EL R L+ + E E + + +++L++ L + + + R + + +L+E
Sbjct: 1578 LEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEM 1637
Query: 157 NLRLS---QQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRR 213
L+LS +Q+++A+++ +LQ ++ L+ Q ++L+ ++ + N +LQS
Sbjct: 1638 ELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSEL 1697
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRER------REHSLELERARSEAGEALS 267
+DL R L+E+ E+G + EE LL ER + SL ++ + EA A
Sbjct: 1698 EDL----RSLQEQTERG----RRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVA-- 1747
Query: 268 ALRRLQRRVSELEE-----ESRLQDADVSAASLQSELAHSLD 304
R+Q+ E+ + E + + A + AA+L EL D
Sbjct: 1748 ---RMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQD 1786
Score = 56.2 bits (134), Expect = 7e-08
Identities = 100/474 (21%), Positives = 195/474 (41%), Gaps = 50/474 (10%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
E + + +L++ + DL L + LL R E++ R EERL + +L
Sbjct: 1220 ENLQQVKQKLEKDKSDLQLEVD---DLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLD 1276
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERA---RALSELSEQNLRLS 161
+ + + A+ +L + +L E+ + RE++ R + +L Q + +
Sbjct: 1277 K-VTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKET 1335
Query: 162 QQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGE---------NQMLQSR 212
+ + + Q+ QR+ D LR Q + + AEL L + E N ++Q R
Sbjct: 1336 KSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQ-R 1394
Query: 213 RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL 272
+DLE + L +++ + + L R R + LEL A S+ G+ SA RL
Sbjct: 1395 TEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARL 1454
Query: 273 QRR-----------VSELEEESRLQDA---DVSAASLQ-SELAHSLDDGDQGQGADAPGD 317
++ + EE L DA +V A S + +L ++ ++ GQ +
Sbjct: 1455 DQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRREN 1514
Query: 318 -------TPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAE---ILEEKEVEVAKLQ 367
+ T + + + ++++E K ++ E LE E ++ Q
Sbjct: 1515 KNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQ 1574
Query: 368 DEISLQQAELQSLREELQRQKE--LRAQEDPGEALHSAL----SDRDEAVNKALELSLQL 421
E+ +AEL+ E + E R Q+ ++L S+L R E ++ L
Sbjct: 1575 LELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDL 1634
Query: 422 NRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSAS 475
N + L+ +R++ A + L +++ Q MQ+ QL S +++++ +
Sbjct: 1635 NEMELQLSCANRQVSEATKSLGQLQIQIKDLQ--MQLDDSTQLNSDLKEQVAVA 1686
Score = 50.8 bits (120), Expect = 3e-06
Identities = 61/275 (22%), Positives = 109/275 (39%), Gaps = 24/275 (8%)
Query: 48 EDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQ--------- 98
+ L L + K + L K + E E+ QL + Q E + L Q
Sbjct: 1607 DSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQ 1666
Query: 99 ----ENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELS 154
++ +L L + A E R L+ ++E LR+ + ++ S E A ++
Sbjct: 1667 MQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERIN 1726
Query: 155 ---EQNLRLSQQLAQASQTEQELQRELDALRGQCQ-------AQALAGAELRTRLESLQG 204
QN L Q + +Q+E + + +CQ A+ A L L+ Q
Sbjct: 1727 LFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQD 1786
Query: 205 ENQMLQSRRQDLEAQIRGLREEVEKGEGR-LQTTHEELLLLRRERREHSLELERARSEAG 263
L+ R+++E I L++ + + E L + +++ L RE ELE +
Sbjct: 1787 TIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSA 1846
Query: 264 EALSALRRLQRRVSELEEESRLQDADVSAASLQSE 298
EA RRL+R + EL ++ ++S Q +
Sbjct: 1847 EAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMD 1881
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 88.2 bits (217), Expect = 2e-17
Identities = 117/507 (23%), Positives = 206/507 (40%), Gaps = 103/507 (20%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLER-------EERLQ 97
E+ L +++ + ++ L L + + + E E +R LE L +QH E+ ++RL+
Sbjct: 614 EQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLE 673
Query: 98 QENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQN 157
+ ELR+ L + + + + ++ L+ QL E E + R R L E+
Sbjct: 674 ESEGELRKNLEEL-FQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEEL 732
Query: 158 LRLSQQLAQ---ASQTEQEL----QRELDALRG--------------------QCQAQAL 190
L+ Q L A + +++L +REL AL+G + QAL
Sbjct: 733 LQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAL 792
Query: 191 -------------------------AGAELRTRLESLQGENQMLQSRRQDLEAQIRGLRE 225
AG E+R +L LQ EN+ LQ R ++LE ++ L+
Sbjct: 793 RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKL--LQEENEKLQGRSEELERRVAQLQR 850
Query: 226 EVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL------------- 272
++E +G E L E R+ L AR E EA+SA R L
Sbjct: 851 QIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ 910
Query: 273 ----QRRVSE-LEEESRLQD---------------ADVSAASLQSELAHSLDDGDQGQGA 312
Q+++SE L+EES ++ + LQ E+A + + +
Sbjct: 911 TTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA-DIVEASRTSTL 969
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAE----ILEEKEVEVAKLQD 368
+ + R+ + Q E+ LE K R + + ++EE+ + + QD
Sbjct: 970 ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 369 EISLQQAELQSLREELQRQKELRAQ-EDPGEALHSALSDRDEAVNKALELSLQLNRVSLE 427
E ++ L+ ++L+ + E ++ +D L + D+ + LE + + E
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089
Query: 428 RDSLSRELLRAIRQKVALTQELEAWQD 454
R S SRE + +R + L QE A QD
Sbjct: 1090 RISRSREQMEQLRNE--LLQERAARQD 1114
Score = 70.9 bits (172), Expect = 3e-12
Identities = 111/461 (24%), Positives = 206/461 (44%), Gaps = 66/461 (14%)
Query: 49 DLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRG-- 106
++ ++L Q+E + L + L R +L+RQ+E L + +E L++ E+R+
Sbjct: 821 EMRVKLLQEENEKLQGRS--EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEE 878
Query: 107 --LAARGAEWEARAVE--LEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
+ AR E EA + LE ++EA + L + EQ+ E+ + SE EQ RL
Sbjct: 879 ALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLS-EKLKEESEQKEQLRRLKN 937
Query: 163 QLAQA----SQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEA 218
++ +T ++LQ+E+ + +A + EL+ +L+ + +N R++L
Sbjct: 938 EMENERWHLGKTIEKLQKEMADI---VEASRTSTLELQNQLDEYKEKN------RRELAE 988
Query: 219 QIRGLRE---EVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRR 275
R L+E E EK +E+ L+ E R++ +RA+ EA L + +
Sbjct: 989 MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDY----QRAQDEALTKRQLLEQTLKD 1044
Query: 276 VS-ELEEESRLQD--------ADVSAASLQSELAHSLDDGD--QGQGADAPGDTPTTRSP 324
+ ELE +S L+D + + L+ EL ++ D + + + R+
Sbjct: 1045 LEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNE 1104
Query: 325 KTRKASSPQPSPPEEI-LEPPKKRTSL-----------SPAEILEEKEVEVAKLQDEISL 372
++ ++ Q ++I LE K S ++ + E +A+L+D +
Sbjct: 1105 LLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLES 1164
Query: 373 QQ---AELQSLREELQRQ-KELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLER 428
++ A LQ L+R+ KEL Q D H +L+D+ + +LSL+L + +
Sbjct: 1165 EERDRANLQLSNRRLERKVKELVMQVDDE---HLSLTDQKD------QLSLRLKAMKRQV 1215
Query: 429 DSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQ 469
+ E+ R K L +ELE Q DM + QL S ++
Sbjct: 1216 EEAEEEIDRLESSKKKLQRELEE-QMDMNEHLQGQLNSMKK 1255
Score = 57.8 bits (138), Expect = 2e-08
Identities = 88/417 (21%), Positives = 165/417 (39%), Gaps = 49/417 (11%)
Query: 90 LEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARA 149
LE++ +L E EL+R L + ++ + E +RA L E RS+ + E +
Sbjct: 613 LEQKSKLTIEVAELQRQLQLEVKNQQ----NIKEERERMRANLEELRSQHNEKVEENSTL 668
Query: 150 LSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQML 209
L E L + L + Q + E ++ +R + EL + S E L
Sbjct: 669 QQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL 728
Query: 210 QSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERRE----HSLELERARSEAGEA 265
+ ++ L E+ E L+ EL L+ +E H E+++ + +
Sbjct: 729 IEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAE 788
Query: 266 LSALR----RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQG------------ 309
L ALR + V L S + D + ++ +L ++ QG
Sbjct: 789 LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL 848
Query: 310 --QGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAK-- 365
Q D GD ++ +T K + EE L +K EEKE A+
Sbjct: 849 QRQIEDLKGD--EAKAKETLKKYEGEIRQLEEALVHARK----------EEKEAVSARRA 896
Query: 366 LQDEISLQQAEL-QSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRV 424
L++E+ Q L Q+ +E+ Q ++L+ + + E L ++E N+ L + ++
Sbjct: 897 LENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRL---KNEMENERWHLGKTIEKL 953
Query: 425 SLERDSLSRELLRAIR-QKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSST 480
E +++ A R + L +L+ +++ + + + R ++K L A S T
Sbjct: 954 QKE----MADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLT 1006
Score = 52.8 bits (125), Expect = 7e-07
Identities = 76/359 (21%), Positives = 144/359 (40%), Gaps = 53/359 (14%)
Query: 144 RERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQ 203
+ RA ++ + Q + ++ + + +L E+ L+ Q Q + ++ E ++
Sbjct: 589 KSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMR 648
Query: 204 GENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLE---LERARS 260
+ L+S+ + + L++ +E+ EG L+ EEL ++ ER +H E L+ S
Sbjct: 649 ANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLS 708
Query: 261 EAGEALSALRRLQRR--------------------VSELEEESRLQDADVSAASLQSELA 300
E + L + +R + R +++ E+E L+ + +L+ L
Sbjct: 709 EMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK 768
Query: 301 HSLDDGDQGQG--------------ADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKK 346
+ DQ T +R +S Q E+ +
Sbjct: 769 EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQ 828
Query: 347 RTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQR-QKELRAQEDPGEALHSALS 405
+ EE E VA+LQ +I + + +E L++ + E+R E EAL A
Sbjct: 829 EENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE---EALVHARK 885
Query: 406 DRDEAVN--KALELSLQ-----LNRVSLERDSLSRELLRAIRQKVALTQ-----ELEAW 452
+ EAV+ +ALE L+ L++ + E+ LS +L QK L + E E W
Sbjct: 886 EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERW 944
Score = 52.4 bits (124), Expect = 1e-06
Identities = 64/261 (24%), Positives = 111/261 (42%), Gaps = 31/261 (11%)
Query: 54 LQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAE 113
L+Q KDL E L + L +Q+E +Q LE E ++ N +L +R E
Sbjct: 1038 LEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQ-LEMELEEERNNSDLLSERISRSRE 1096
Query: 114 WEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQE 173
+E LR +L ++R+ +QD ++ L QN L ++ E
Sbjct: 1097 ----------QMEQLRNELLQERAARQDLECDKI----SLERQNKDLKSRIIHL---EGS 1139
Query: 174 LQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGR 233
+ + L Q +A+ AEL RLES + + LQ + LE +++ L +V+
Sbjct: 1140 YRSSKEGLVVQMEARI---AELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLS 1196
Query: 234 LQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSE-------LEEESRLQ 286
L ++L L + + ++E A E S+ ++LQR + E L+ +
Sbjct: 1197 LTDQKDQLSLRLKAMKR---QVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSM 1253
Query: 287 DADVSAASLQSELAHSLDDGD 307
D+ L S++ +DD D
Sbjct: 1254 KKDLRLKKLPSKVLDDMDDDD 1274
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/195 (23%), Positives = 91/195 (46%), Gaps = 22/195 (11%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQL--ETLSAQHLEREE-RLQQENH 101
++ L ++L+++ + L +E E+ E+LR +L E + Q LE ++ L+++N
Sbjct: 1068 DKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
Query: 102 ELR-RGLAARGA----------EWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARAL 150
+L+ R + G+ + EAR ELE +E+ R+ Q S R R +
Sbjct: 1128 DLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEE----RDRANLQLSNRRLERKV 1183
Query: 151 SEL----SEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGEN 206
EL +++L L+ Q Q S + ++R+++ + + +L+ LE N
Sbjct: 1184 KELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMN 1243
Query: 207 QMLQSRRQDLEAQIR 221
+ LQ + ++ +R
Sbjct: 1244 EHLQGQLNSMKKDLR 1258
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 83.2 bits (204), Expect = 5e-16
Identities = 118/489 (24%), Positives = 216/489 (44%), Gaps = 72/489 (14%)
Query: 48 EDLALQLQQKEKDLLLAAELGKML---LERNEELRRQLETLSAQHLEREERLQQENHELR 104
E LAL + LL E + + +E E+ R L+ A+ +R E L ++N L
Sbjct: 606 EALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665
Query: 105 RGLAAR---GAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLS 161
L GAE +A +++ + E ++ +L E R +Q+ + + L +L ++ R
Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ----LEQLHQEAKRQE 721
Query: 162 QQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIR 221
+ LA+A Q ++ L RE AL + QA +L +L+ L ++L+S EAQ +
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL--FEAQQQ 779
Query: 222 GLREEVEKG--EGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL-----QR 274
EV KG E ++QT + +++ E R LEL+ RS+A + A R Q
Sbjct: 780 NSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQE 839
Query: 275 RVSELEEESRLQDADVS---------AASLQSELAHSLDDGDQGQG------ADAPGDTP 319
+ LE++ + +V+ + Q ELA +L+ ++ + + +
Sbjct: 840 GKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEME 899
Query: 320 TTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQS 379
++ + + + + + + LE K+R SL + +KE+ A Q E Q ++Q
Sbjct: 900 AIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQK 959
Query: 380 LREE----------LQRQKEL----RAQEDPGEALH----SALSDRDEAVNKALELSLQL 421
L+E+ + Q+EL R D AL S L D+ + + +L QL
Sbjct: 960 LKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQL 1019
Query: 422 NRVSLERDSLSRELLRAIRQKVALTQE----------------LEAWQDDMQVVIGQQLR 465
+ +D R + + +++K+ TQE L + + ++++ Q+
Sbjct: 1020 ----VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEAD 1075
Query: 466 SQRQKELSA 474
S RQ+ELSA
Sbjct: 1076 SIRQQELSA 1084
Score = 77.4 bits (189), Expect = 3e-14
Identities = 114/441 (25%), Positives = 184/441 (41%), Gaps = 73/441 (16%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELR--RQLETLSAQHL-------EREER 95
E+ E + L L+++ ++L +L + ER EE + + + S +H+ E+E
Sbjct: 1683 EDLEQIKLSLRERGRELTTQRQL---MQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE 1739
Query: 96 LQQEN-HELR----------RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQ----- 139
QQE+ HEL+ +GL + E + E ++ L+ QL E R +
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799
Query: 140 --QDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRT 197
Q E RAL++ ++ L Q+ QA E+ ++ + DAL+G + +
Sbjct: 1800 SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE-------QAHM 1852
Query: 198 RLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELER 257
L+ GE QD + Q R L EE+ R+Q E L LR E RE L
Sbjct: 1853 TLKERHGE-------LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLA 1905
Query: 258 ARSEAGEALSALRRLQRRVSELEEESR-LQDADVSAASLQSELAHSLDDGDQGQGADAPG 316
+ + E + E E E+R LQD+ + A ++ E L + A++
Sbjct: 1906 LQQQCAE----------QAQEHEVETRALQDSWLQAQAVLKERDQEL----EALRAESQS 1951
Query: 317 DTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE 376
+ + R + + K++ L AE+ E A LQ + QA
Sbjct: 1952 SRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAH 2011
Query: 377 LQSLREELQRQ------KELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDS 430
+ L E L+ Q ++LR QED + L AL+ RDE EL Q R L S
Sbjct: 2012 SRQLEEALRIQEGEIQDQDLRYQEDV-QQLQQALAQRDE------ELRHQQEREQLLEKS 2064
Query: 431 LSRELL-RAIRQKVALTQELE 450
L++ + I++K L QE E
Sbjct: 2065 LAQRVQENMIQEKQNLGQERE 2085
Score = 75.9 bits (185), Expect = 8e-14
Identities = 113/479 (23%), Positives = 206/479 (43%), Gaps = 56/479 (11%)
Query: 46 EPEDLALQLQQKEKDLL--LAAELGKMLLERN-EELRRQLETLSAQHLEREERL---QQE 99
+ E LA +Q+KE + A E+ +ER+ ++L QL+ LS+ E L QQ+
Sbjct: 720 QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQ 779
Query: 100 NH--ELRRGLAARGAEWEARAVE-LEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQ 156
N E+ +G + +A E ++G+V L+ +L +RS+ + AR L++ ++
Sbjct: 780 NSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQE 839
Query: 157 NLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGA---------ELRTRLESLQGENQ 207
+Q A + E RE Q LA A EL RL+ Q E +
Sbjct: 840 GKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEME 899
Query: 208 MLQSRRQDLEAQIRG----LREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSE-- 261
+Q++R++ Q ++ E EK L T LL ++E + S +LER R +
Sbjct: 900 AIQAQREEERTQAESALCQMQLETEKERVSLLET---LLQTQKELADASQQLERLRQDMK 956
Query: 262 ---------AGEALSALRRLQRRVSELEEESR-----LQDADVSAASLQSELAHSLDDGD 307
G + L+ QR + E + R LQ+ S + +L ++D
Sbjct: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
Query: 308 QGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQ 367
A + + + + + + ++ LE K +LS L EKE + LQ
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLS----LMEKEQRLLVLQ 1072
Query: 368 DEISLQQAELQSLREELQ----RQKELRAQEDPGEALHSALSDRD-EAVNKALELSLQLN 422
+ S++Q EL +LR+++Q QKEL AQ E L + +++ + + + +L +L
Sbjct: 1073 EADSIRQQELSALRQDMQEAQGEQKELSAQM---ELLRQEVKEKEADFLAQEAQLLEELE 1129
Query: 423 RVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQL---RSQRQKELSASASS 478
+ L L + L L + + ++ + +Q ++Q Q +L++ S+
Sbjct: 1130 ASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA 1188
Score = 73.9 bits (180), Expect = 3e-13
Identities = 107/430 (24%), Positives = 195/430 (45%), Gaps = 53/430 (12%)
Query: 48 EDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERL---QQENHELR 104
E L+L L+++ +++ L E ++ E+ R LE L ERE++L +++ EL
Sbjct: 1459 ELLSLDLKKRNQEVDLQQEQ----IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
+ + E + +ELE + + +Q G+ + ++ AL EL E + ++
Sbjct: 1515 KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL-ELEENHHKM---- 1569
Query: 165 AQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLR 224
+ +Q+L +EL+ GQ + Q +A L LE E Q S+ DLE+ L
Sbjct: 1570 ----ECQQKLIKELE---GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
Query: 225 EEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESR 284
E+++ + +++ E++ L+R++ + +LER E LQ+ ++ E+ R
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL--------MLQKERIQVLEDQR 1674
Query: 285 LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPP 344
+ + L+ ++ SL + G TT+ ++ + P +
Sbjct: 1675 TRQTKILEEDLE-QIKLSLRE---------RGRELTTQRQLMQERAEEGKGPSK------ 1718
Query: 345 KKRTSLSPAE-ILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSA 403
+R SL + IL +KE EV Q+ I ELQ L+++L++Q + GE
Sbjct: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIH----ELQELKDQLEQQLQ-GLHRKVGET-SLL 1772
Query: 404 LSDRDEAVNKALELSLQLNRV--SLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIG 461
LS R++ + L+ LQ R L+ SL +L A R QELEA Q + Q G
Sbjct: 1773 LSQREQEI-VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831
Query: 462 QQLRSQRQKE 471
Q+ R + + +
Sbjct: 1832 QEERVKEKAD 1841
Score = 70.1 bits (170), Expect = 5e-12
Identities = 126/530 (23%), Positives = 211/530 (39%), Gaps = 117/530 (22%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETL--SAQHLER----------- 92
E + LA Q + ++ ++ ++L + EELR+QLE L A L R
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDS 502
Query: 93 ----EERLQQENH----------ELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSE 138
+E Q+E H E+ GL A+ +E + + L +E+ + R E
Sbjct: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQE 562
Query: 139 QQDSGRERARA---------------------------LSELSE----QNLRLSQQLAQA 167
Q + ARA LS L+E + L+QQL Q
Sbjct: 563 QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQL 622
Query: 168 SQTEQELQRELDA----------------------------LRGQCQAQALAGAELRTRL 199
+ Q + ++A L Q Q AGAEL+ L
Sbjct: 623 EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADL 682
Query: 200 ESLQGENQMLQSR----RQDLEA---QIRGLREEVEKGEGRLQTTHEELLLLRRERREHS 252
+Q E + +Q + R EA Q+ L +E ++ E L +E L RE+
Sbjct: 683 RDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALE 742
Query: 253 LEL---ERARSEAGEAL----SALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDD 305
+ L ER R + E L SA L+ + E ++++ + + +Q + +
Sbjct: 743 VRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKE 802
Query: 306 GDQGQ--GADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEV 363
QG+ DT +++ + R A++ Q + E+ + +T+L + EKEV
Sbjct: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ-----EGKTALEQQKAAHEKEVNQ 857
Query: 364 --AKLQDEISLQQAELQSLREELQRQK---ELRAQEDPGEALHSALSDRDEAVNKALELS 418
K + E S Q EL E L+R+K E+R +E E + + + R+E +A
Sbjct: 858 LREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE-MEAIQAQREEERTQAESAL 916
Query: 419 LQLN-RVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQ 467
Q+ ER SL LL+ ++ +Q+LE + DM+V Q+L+ Q
Sbjct: 917 CQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV---QKLKEQ 963
Score = 67.8 bits (164), Expect = 2e-11
Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 66/480 (13%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
++ E A+Q Q++E+ + L +M LE +E LETL L+ ++ L + +L
Sbjct: 894 QQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETL----LQTQKELADASQQLE 949
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
R + + + ++ + L+ QL E + E +++ R+ L+ L E++ L Q
Sbjct: 950 R----LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDK 1005
Query: 165 AQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQM--------------LQ 210
+ ++L+ +L A Q +Q L E++ +L Q N++ L
Sbjct: 1006 MDLQKQVEDLKSQLVA---QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLM 1062
Query: 211 SRRQDL----------EAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARS 260
+ Q L + ++ LR+++++ +G + ++ LLR+E +E + +
Sbjct: 1063 EKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEA 1122
Query: 261 EAGEALSA--LRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDT 318
+ E L A + Q R S +E++ + S +S+L + G A A
Sbjct: 1123 QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
Query: 319 PTTRSPKTRKASSPQPSPPEEI-----------LEPPK-------KRTSLSPAEILEEKE 360
+ S + S S PE LEP + KR L A E
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
Query: 361 VEVAKLQDEISLQQAELQSLREELQRQKE-LRAQEDPGEALHSALSDRDEAVNKALELSL 419
+ KL ++ Q LR+++Q+ +E L E +H+ L D +++ E
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQE--- 1299
Query: 420 QLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSS 479
+ ++ +++SL EL+ L + + + Q ++ Q++ +Q ++EL +A +
Sbjct: 1300 EKSKWEGKQNSLESELME-------LHETMASLQSRLRRAELQRMEAQGERELLQAAKEN 1352
Score = 66.2 bits (160), Expect = 7e-11
Identities = 98/429 (22%), Positives = 178/429 (41%), Gaps = 45/429 (10%)
Query: 55 QQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEW 114
Q +K L L + + ++LR+QL A E LQQ++ + G
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQL----AGCQEAVNLLQQQHDQWEE----EGKAL 433
Query: 115 EARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQEL 174
R +L G+ + L Q + + E +ER +L Q ++ +EL
Sbjct: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKER----------------ELLQKAR--EEL 475
Query: 175 QRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRL 234
+++L+ L + EL+ + +S QG+ + Q + L+E + E +
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQ 535
Query: 235 QTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSEL---EEESRLQDADVS 291
+ EL+ LR LE E R E E +AL R ++ ++EL E + + AD+
Sbjct: 536 SESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLR 595
Query: 292 AASLQSEL---AHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRT 348
AA+++ A +LD Q + + + A + + ++ E K+R
Sbjct: 596 AAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRRE 655
Query: 349 SLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQR-QKELRAQEDPGEALHSALSDR 407
+L E E ++ K ++ + QA+L+ ++EE + QK+L EA + L
Sbjct: 656 AL--WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQL 713
Query: 408 DEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQ 467
+ + E+ L R E+++L +R+K AL L+A + D Q + Q
Sbjct: 714 HQEAKRQEEV---LARAVQEKEAL-------VREKAALEVRLQAVERDRQDLAEQLQGLS 763
Query: 468 RQKELSASA 476
KEL S+
Sbjct: 764 SAKELLESS 772
Score = 64.7 bits (156), Expect = 2e-10
Identities = 114/472 (24%), Positives = 201/472 (42%), Gaps = 64/472 (13%)
Query: 45 EEPEDLALQL-QQKEKDLLLAAELGKMLLERNE------ELRRQLETLSAQHLEREERL- 96
++ EDL QL Q + L+ E+ + L E E EL R+ +L+ +E+E+RL
Sbjct: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069
Query: 97 ---------QQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSE--QQDSGRE 145
QQE LR+ + E + EL +E LR ++ E+ ++ Q++
Sbjct: 1070 VLQEADSIRQQELSALRQDMQ----EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLL 1125
Query: 146 RARALSELSEQNLRLS--QQLAQASQTEQEL---QRELDALRGQCQA--QALAGAELRTR 198
S ++EQ LR S Q A+A+Q + L + +L+AL + Q QA A A+L +
Sbjct: 1126 EELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASL 1185
Query: 199 LESLQGE-NQMLQSRRQ-----DLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHS 252
+LQ + +SR + D + GL + + G L L L E +
Sbjct: 1186 YSALQQALGSVCESRPELSGGGDSAPSVWGLEPD-QNGARSLFKRGPLLTALSAEAVASA 1244
Query: 253 LELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGA 312
L + + + L+ +V +LEE RL D + + + +EL Q Q
Sbjct: 1245 LH--KLHQDLWKTQQTRDVLRDQVQKLEE--RLTDTEAEKSQVHTELQDLQRQLSQNQ-- 1298
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISL 372
+ K Q S E++E + SL L E++ + Q E L
Sbjct: 1299 -----------EEKSKWEGKQNSLESELMELHETMASLQSR--LRRAELQRMEAQGEREL 1345
Query: 373 QQAELQSLREELQRQK----ELRAQEDPGEALHSALSDRDEAV---NKALELSLQLNRVS 425
QA ++L +++ + E RAQ L L A+ N+ +E + +
Sbjct: 1346 LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL 1405
Query: 426 LERDSLSRELLRAIRQKVAL-TQELEAWQDDMQVVIGQQLRSQRQKELSASA 476
E+ L +A+++ +AL TQ L +++++ + GQ ++Q+E+ +A
Sbjct: 1406 QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA 1457
Score = 63.9 bits (154), Expect = 3e-10
Identities = 99/408 (24%), Positives = 168/408 (41%), Gaps = 63/408 (15%)
Query: 70 MLLERNEELRR-QLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAV----ELEGD 124
+L ER++EL + E+ S++H E R + E + G A + + + + EL
Sbjct: 1934 VLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRS 1993
Query: 125 VEALRAQLGEQRSEQQDSGRERARAL----SELSEQNLRLSQQLAQASQTEQELQRELDA 180
+EA A L Q R+ AL E+ +Q+LR + + Q +Q L + +
Sbjct: 1994 LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDV---QQLQQALAQRDEE 2050
Query: 181 LRGQCQAQALAGAELRTRL-ESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHE 239
LR Q + + L L R+ E++ E Q L R+ E +IRGL + V + + L +
Sbjct: 2051 LRHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE--EEEIRGLHQSVRELQLTLAQKEQ 2108
Query: 240 ELLLLRRERREHSLEL---------------------ERARSEAGEALSALRRLQRRVSE 278
E+L LR ++ ++LE R + E +ALR+ + R E
Sbjct: 2109 EILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIE 2168
Query: 279 LEEESR-----LQDADVSAASLQSE---LAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 330
E+++ L S +SLQ L S+ + D Q T R+ + +
Sbjct: 2169 WREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLH 2228
Query: 331 SPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL 390
SP + E+ ++ L EV+ ++ E S E QS R+ L+ ++
Sbjct: 2229 SPGATSTAELGSRGEQGVQLG----------EVSGVEAEPSPDGMEKQSWRQRLEHLQQA 2278
Query: 391 RAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRA 438
A+ + DR ++L L +V ER L RE +RA
Sbjct: 2279 VARLE---------IDRSRLQRHNVQLRSTLEQVERERRKLKREAMRA 2317
Score = 61.6 bits (148), Expect = 2e-09
Identities = 108/501 (21%), Positives = 190/501 (37%), Gaps = 93/501 (18%)
Query: 46 EPEDLALQLQQKEKDLLLAAELG---------------------KMLLERNEELRRQLET 84
E L L L +KE+ LL+ E K L + E LR++++
Sbjct: 1053 EKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE 1112
Query: 85 LSAQHLEREERLQQE---NHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQD 141
A L +E +L +E +H + L A EA+A +L+ + + +QL +EQQ
Sbjct: 1113 KEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQP 1172
Query: 142 SGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDA--------------------- 180
+ +A+A +L+ L Q L ++ EL D+
Sbjct: 1173 GNQAQAQA--QLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRG 1230
Query: 181 -LRGQCQAQALAGA-----------------------ELRTRLESLQGENQMLQSRRQDL 216
L A+A+A A +L RL + E + + QDL
Sbjct: 1231 PLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDL 1290
Query: 217 EAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRV 276
+ Q+ +EE K EG+ + EL+ L L RA + EA LQ
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAK 1350
Query: 277 SELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSP 336
L + A V A Q+ A L++ D T RS K +
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAGILEE-----------DLRTARSALKLKNEEVESER 1399
Query: 337 PEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLR---EELQRQKELRAQ 393
+ ++ + L+E +A L ++ ++ E+++LR +EL++Q+E+ Q
Sbjct: 1400 ERAQALQEQGELKVAQGKALQE---NLALLTQTLAEREEEVETLRGQIQELEKQREM--Q 1454
Query: 394 EDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLS---RELLRAIRQKVALTQELE 450
+ E L L R++ V+ E +L + + L +E + + + +ELE
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
Query: 451 AWQDDMQVVIGQQLRSQRQKE 471
++ + V+ QL +K+
Sbjct: 1515 KDRETQRNVLEHQLLELEKKD 1535
Score = 59.7 bits (143), Expect = 6e-09
Identities = 99/411 (24%), Positives = 168/411 (40%), Gaps = 56/411 (13%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGA 112
Q++Q+ L E G++L L R++ T LE + ++ EL+
Sbjct: 160 QMEQEFFKGYLKGEHGRLL-----SLWREVVTFRRHFLEMKSATDRDLMELK-------- 206
Query: 113 EWEARAVELEGDVEA--LRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQT 170
A V L G + LR +G Q E SGR R ++L L L + + +
Sbjct: 207 ---AEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQL----LLLLAKTQELEKE 259
Query: 171 EQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKG 230
E +EL L+ Q L AEL+ R+ L Q + +D E I+ LRE VE
Sbjct: 260 AHERSQELIQLKSQGD---LEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE-- 314
Query: 231 EGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADV 290
L+T H EL+ EH L R E E LS LQ+ + ++ + +++ D
Sbjct: 315 --ILETNHTELM-------EHEASLSRNAQE--EKLS----LQQVIKDI-TQVMVEEGDN 358
Query: 291 SAASLQSELAHSLDDG--DQGQGADAPGDTPTTRSPKTRKASSPQPSPPE--------EI 340
A E + LD Q DA RS TR+ + Q + +
Sbjct: 359 IAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNL 418
Query: 341 LEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL--RAQEDPGE 398
L+ + + L ++ ++ +D ++ Q +LQ + L +++EL +A+E+ +
Sbjct: 419 LQQQHDQWE-EEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ 477
Query: 399 ALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQEL 449
L + +EL LQ + +++ EL A+R++ L + L
Sbjct: 478 QLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEML 528
Score = 50.8 bits (120), Expect = 3e-06
Identities = 96/397 (24%), Positives = 155/397 (39%), Gaps = 40/397 (10%)
Query: 66 ELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAV-----E 120
+L + L +R+EELR Q E +R+Q+ + ++ L E E R + E
Sbjct: 2039 QLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE 2098
Query: 121 LEGDVEALRAQLGEQRSEQQDSGRE---RARALSELSEQNLRLSQQLAQASQTEQELQRE 177
L+ + ++ E R QQ + E + S + EQ+L+L E LQRE
Sbjct: 2099 LQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDS-------LEPRLQRE 2151
Query: 178 LDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTT 237
L+ L+ + E R + + L ++ L+ L+ V + + Q
Sbjct: 2152 LERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL 2211
Query: 238 HEELLLLRRERREHSLELERA--------RSEAGEALSALRRLQRRVSE--LEEES---R 284
+EL L RR + L A R E G L + ++ S +E++S R
Sbjct: 2212 QDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQR 2271
Query: 285 LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPP 344
L+ + A L E+ S Q R R+A + EI
Sbjct: 2272 LEHLQQAVARL--EIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEI---- 2325
Query: 345 KKRTSLSPAEILEEKEVE-----VAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEA 399
K T+ SP + + VA+LQ E+ L QA+L R++ Q AQ A
Sbjct: 2326 SKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELA 2385
Query: 400 -LHSALSDRDEAVNKALELSLQLNRVSLERDSLSREL 435
LH +LS AV +A E ++ +SL++ L
Sbjct: 2386 GLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSL 2422
Score = 38.9 bits (89), Expect = 0.011
Identities = 73/305 (23%), Positives = 125/305 (40%), Gaps = 43/305 (14%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
+ E ++ ++K +DL L+ K + +E+ L+ + ++RLQ E RR
Sbjct: 2161 QTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR 2220
Query: 106 GL---------AARGAEWEAR---AVELEGDVEALRAQLGEQRSEQQDSGRER----ARA 149
L A AE +R V+L G+V + A+ E+Q S R+R +A
Sbjct: 2221 ALEKERLHSPGATSTAELGSRGEQGVQL-GEVSGVEAEPSPDGMEKQ-SWRQRLEHLQQA 2278
Query: 150 LSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQML 209
++ L RL + Q T ++++RE L+ + A AG SL+
Sbjct: 2279 VARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAG--------SLEISKATA 2330
Query: 210 QSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSAL 269
S Q RG + K LQ +E++LL+ + L LER + + + ++
Sbjct: 2331 SSPTQQ---DGRGQKNSDAKCVAELQ---KEVVLLQAQ-----LTLERKQKQ--DYITRS 2377
Query: 270 RRLQRRVSELE---EESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKT 326
+ R ++ L S L A A++ LD+ Q +PG SP T
Sbjct: 2378 AQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDE-SLTQSLTSPGPVLLHPSPST 2436
Query: 327 RKASS 331
+A+S
Sbjct: 2437 TQAAS 2441
Score = 38.1 bits (87), Expect = 0.019
Identities = 88/403 (21%), Positives = 154/403 (38%), Gaps = 84/403 (20%)
Query: 42 PGPEEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENH 101
PG + +LQL +E+ L L ++ + + S + L+ + QQ
Sbjct: 6 PGLNNMKPQSLQLVLEEQVLALQQQMAEN------------QAASWRKLKNSQEAQQRQA 53
Query: 102 ELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLS 161
L R L A+ ++ + ELE +EA + ++ ++ L E +RL
Sbjct: 54 TLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPN---------LDELLVRL- 103
Query: 162 QQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIR 221
E+E QR C++ A +LR +E N+ L+ + L
Sbjct: 104 ---------EEEQQR--------CESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWS 146
Query: 222 GLREEVEKGE-----------GRLQTTHEELLLLRRE---RREHSLELERARSEAGEALS 267
R+E+ + E G L+ H LL L RE R H LE++ A
Sbjct: 147 RARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSA--------- 197
Query: 268 ALRRLQRRVSELE-EESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKT 326
R + EL+ E RL + ++ + A S + G+ G P
Sbjct: 198 ----TDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGR---MDGREPAQLLLLL 250
Query: 327 RKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAEL-QSLREELQ 385
K LE S ++ + ++E A+LQD ++ A L QS ++
Sbjct: 251 AKTQE---------LEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED 301
Query: 386 RQKELRAQEDPGEAL---HSALSDRDEAVNK-ALELSLQLNRV 424
+K ++A + E L H+ L + + ++++ A E L L +V
Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQV 344
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 82.4 bits (202), Expect = 9e-16
Identities = 116/470 (24%), Positives = 189/470 (40%), Gaps = 41/470 (8%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E ++L + Q++E+ ++ ++ EE R Q E Q RE++ ++ +LRR
Sbjct: 282 ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341
Query: 106 GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSEL-SEQNLRLSQQL 164
R + R E E + LR + E+R EQQ ++ R +L EQ LR QQL
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 165 AQASQ--------TEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDL 216
+ Q EQ+L+RE R Q + + E R + L+ E + RR L
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ---EERRDWL 458
Query: 217 EAQIRGLREEVEKGEGRLQTTHEELLLLRRERREH--SLELERARSEAGEALSALRRLQ- 273
+ + R E E+ + +L+ EE ERRE LE E R + LRR Q
Sbjct: 459 KREEETERHEQERRKQQLKRDQEE------ERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 274 ----RRVSELEEESRLQDADVSAASLQSELAH------------SLDDGDQGQGADAPGD 317
+R+ EEE RLQ S L+ E L+ + Q +
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 318 TPTTRSPKTRKASSPQ--PSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQA 375
+ K + Q EE LE KR + E E +E + + + E +Q
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ 632
Query: 376 ELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSREL 435
L+S +E +RQ++LR ++ + +E + + L+ + R E +E
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Query: 436 LR-AIRQKVALTQ-ELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRR 483
R I+ ++ Q +LE+ D Q + + R Q + RR
Sbjct: 693 ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742
Score = 82.4 bits (202), Expect = 9e-16
Identities = 112/472 (23%), Positives = 185/472 (39%), Gaps = 63/472 (13%)
Query: 54 LQQKEKDLLLAAELGKMLLERNEELRRQ-----LETLSAQHLEREERLQQENHELRRGLA 108
LQ++E+ L E + LE ++LRRQ + E E + +E +L R
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR 1529
Query: 109 ARGAEWEARAVELEGDVEALRA----------QLGEQRSEQQDSGRERARALSELSEQNL 158
R E + + + + R QL ++R EQQ S +ER R L EQ +
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKF-RLEEQKV 1588
Query: 159 RLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQG-ENQML-------- 209
R +Q + + EQ+L+R+ GQ Q + + R + LQ E Q L
Sbjct: 1589 RRQEQERKFMEDEQQLRRQ----EGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644
Query: 210 ------QSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAG 263
Q RRQ+ E Q+R R+ + E +L EE L R+ER E E+
Sbjct: 1645 FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ----- 1699
Query: 264 EALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRS 323
LRR +R L+EE +L+ ++ + E + +Q R
Sbjct: 1700 -----LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ-----------LRRQ 1743
Query: 324 PKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREE 383
+ RK EE L P ++ L E + K E +L+ E QQ Q +
Sbjct: 1744 ERYRKILE------EEQLRPEREEQQLRRQE-RDRKFREEEQLRQEREEQQLRSQESDRK 1796
Query: 384 LQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKV 443
+ +++LR + + + + + L+L Q R+ ERD R + Q+
Sbjct: 1797 FREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEK 1856
Query: 444 ALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRLGPG 495
+ +E E WQ++ Q ++ R R++ + R + G G
Sbjct: 1857 SRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKG 1908
Score = 77.4 bits (189), Expect = 3e-14
Identities = 112/443 (25%), Positives = 190/443 (42%), Gaps = 47/443 (10%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
+E E L + Q++++L E + L + RQ E Q L RE++L+++ E R
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 105 R-GLAARGAEWEARAVELEGDVEALRAQLGEQRS-----EQQDSGRE---RARALSELSE 155
R R + E R + E + LR + E+R EQ++ RE R E E
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 156 QNLRLSQQLAQASQ--TEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRR 213
Q LR QQL + Q EQ+L+RE R Q Q +LR R + L+ E Q+ + +
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQ---QLRREQQLR-REQQLRREQQLRREQE 430
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHEELL-LLRRERREHSLELERARSEAGEALSALRRL 272
++ Q + E E+ E RL+ EE L+RE E ER + + RR
Sbjct: 431 EERHEQ----KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR- 485
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSP 332
R +LEEE R + + L+ E + + R + +
Sbjct: 486 -ERWLKLEEEERREQQERREQQLRRE-------------QEERREQRLKRQEEEERLQQR 531
Query: 333 QPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQS---LREELQRQKE 389
S + E ++R L E EEK +E + + + +Q E + REE +RQ+
Sbjct: 532 LRSEQQLRREQEERREQLLKRE--EEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589
Query: 390 LRAQEDPGEALHSALSDRD-EAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQE 448
L+ +++ E L L + E + + +L R E + ++LL++ Q+ Q+
Sbjct: 590 LKREQE--ERLEQRLKREEVERLEQEERREQRLKREEPEEER-RQQLLKSEEQEERRQQQ 646
Query: 449 LEAWQDDMQVVIGQQLRSQRQKE 471
L Q + + Q+L+ + ++E
Sbjct: 647 LRREQQERR---EQRLKREEEEE 666
Score = 74.7 bits (182), Expect = 2e-13
Identities = 117/468 (25%), Positives = 192/468 (41%), Gaps = 88/468 (18%)
Query: 32 ERRDSFLGGGPGPEEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLE 91
+R FL P EE E Q +++EK+L LE E+L+R+ Q E
Sbjct: 805 QREQRFL---PEEEEKEQRRRQRREREKEL--------QFLEEEEQLQRRERAQQLQ--E 851
Query: 92 REERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALS 151
E+ LQ++ R R +W R QL E+R + R A
Sbjct: 852 EEDGLQEDQERRRSQEQRRDQKW--------------RWQLEEERKRR----RHTLYAKP 893
Query: 152 ELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQS 211
L EQ LR QQL Q + E+ELQRE R + + + E E LQ E + L
Sbjct: 894 ALQEQ-LRKEQQLLQ--EEEEELQREEREKRRRQEQERQYREE-----EQLQQEEEQL-- 943
Query: 212 RRQDLEAQIRGLREEVEKGEGRLQTTHEELL------LLRRERREHSLELERARSEAGEA 265
R++ E + R RE + + +LQ E+LL R+ER + E E + E +
Sbjct: 944 LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL 1003
Query: 266 LSALRRLQRRVS-----------ELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADA 314
L R +RR + EEE L++ + E + ++ Q +
Sbjct: 1004 LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQL 1063
Query: 315 PGDTPTTR-----SPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDE 369
G+ TR + RK Q + + E P+KR +E+E + ++E
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR-------QERE---RQCREE 1113
Query: 370 ISLQQAELQSLREELQR------QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNR 423
LQQ E Q LREE ++ +++ R +E+ + L + E + +L R
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ-----ELER 1168
Query: 424 VSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKE 471
E + L +E + +R++ QE + + Q ++L+ Q++K+
Sbjct: 1169 QYREEEELQQEEEQLLREE----QEKRRQERERQYREEEELQRQKRKQ 1212
Score = 73.9 bits (180), Expect = 3e-13
Identities = 106/471 (22%), Positives = 198/471 (42%), Gaps = 50/471 (10%)
Query: 45 EEPEDLALQLQQKEKDL----LLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQEN 100
+E E+ L+ Q++++ L E G+ LE + LRRQ E++ R Q+
Sbjct: 1346 QEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE 1405
Query: 101 HELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRL 160
+LR+ + E E + E D + + +R E++ E + L + + R
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Query: 161 SQQLAQASQTEQELQRELD--------ALRGQCQAQALAGAELRT------------RLE 200
+QL Q + +Q ++E D LR Q + + ELR+ +L
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 201 SLQGENQMLQS----RRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRER-REHSLEL 255
Q + + LQ RRQ+ Q R R+ + E +L+ EE L R+ER R+ LE
Sbjct: 1526 RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585
Query: 256 ERARSEAGEA--LSALRRLQRRVSE-----------LEEESRLQDADVSAASLQSELAHS 302
++ R + E + ++L+R+ + E+E LQ+ + Q
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 303 LDDGDQGQGADAPGDTPTTRSPKTRKASS-PQPSPPEEILEPPKKRTSLSPAEILEEKEV 361
L++ Q + + R K R+ Q +++ + R + L +E
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQER 1705
Query: 362 EVAKLQDEISLQQAELQ-SLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQ 420
E LQ+E L++ EL+ REE Q ++E ++ + + + + ++ + E Q
Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE--QQ 1763
Query: 421 LNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKE 471
L R +R E LR R++ Q+L + + D + +QLR +R+++
Sbjct: 1764 LRRQERDRKFREEEQLRQEREE----QQLRSQESDRKFREEEQLRQEREEQ 1810
Score = 72.0 bits (175), Expect = 1e-12
Identities = 114/449 (25%), Positives = 187/449 (41%), Gaps = 88/449 (19%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGA 112
+LQQ+E+ LL R E +R+L+ Q+ E EE LQQE +L G
Sbjct: 1025 ELQQEEEQLL-----------REEREKRRLQERERQYREEEE-LQQEEEQLL------GE 1066
Query: 113 EWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
E E R R +L Q ++++ +E + L E E+ R Q+ + + E+
Sbjct: 1067 ERETRR----------RQELERQYRKEEELQQEEEQLLREEPEKRRR--QERERQCREEE 1114
Query: 173 ELQRELDAL----RGQCQAQALAGAELRTRLESLQGENQMLQS-----RRQDLEAQIRG- 222
ELQ+E + L R + + Q L + R E Q E Q+L+ RRQ+LE Q R
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELE-RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 223 ----------LREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAG-----EALS 267
LREE EK + + E L+R++R+ E RS+ E +
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Query: 268 ALR--RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPK 325
A+R ++ + E E+ +L+D+ + Q +L H L G+Q + R +
Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL--GEQQE---------RDREQE 1282
Query: 326 TRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQ 385
R+ PEE E LE +E + AK +D S Q E Q LREE +
Sbjct: 1283 RRRWQQRDRHFPEE--------------EQLEREEQKEAKRRDRKS--QEEKQLLREERE 1326
Query: 386 RQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVAL 445
++ + + L +R+E + E + L R+ L ++
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386
Query: 446 TQELEAWQDDMQVVI---GQQLRSQRQKE 471
+E + +++ Q+ QQLR R ++
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRK 1415
Score = 65.9 bits (159), Expect = 9e-11
Identities = 112/444 (25%), Positives = 185/444 (41%), Gaps = 54/444 (12%)
Query: 51 ALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAAR 110
ALQ Q +++ LL E ++ E E+ RRQ + Q+ E E+ Q+E LR R
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ--ERQYREEEQLQQEEEQLLREEREKR 951
Query: 111 GAEWEARAVELEGDVEALRAQL-GEQRSEQQDSGRERA----RALSELSEQNLRLSQQLA 165
+ R + ++ QL GE+ +++ RE+ L + EQ LR ++
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 166 QASQTEQEL-------QRELDALRGQCQAQALAGAELRTRLES-LQGENQMLQS------ 211
+ + E++ Q E LR + + + L E + R E LQ E + L
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Query: 212 RRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRR 271
RRQ+LE Q R EE+++ E +L EE RR+ RE E + E L R
Sbjct: 1072 RRQELERQYRK-EEELQQEEEQL--LREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 272 LQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASS 331
+RR ELE + R ++ +Q E L + + + + R+
Sbjct: 1129 EKRRRQELERQYREEE------EVQQEEEQLLREEPEKRRRQ-------ELERQYREEEE 1175
Query: 332 PQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELR 391
Q + + E +KR + EE+E++ +Q Q R+E QR +L+
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQ----------RQKRKQRYRDEDQR-SDLK 1224
Query: 392 AQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAI---RQKVALTQE 448
Q +P E ++ ++ + E QL L RD S++ L+ + +Q+ QE
Sbjct: 1225 WQWEP-EKENAVRDNKVYCKGRENEQFRQLEDSQL-RDRQSQQDLQHLLGEQQERDREQE 1282
Query: 449 LEAWQD-DMQVVIGQQLRSQRQKE 471
WQ D +QL + QKE
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKE 1306
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/491 (20%), Positives = 186/491 (37%), Gaps = 68/491 (13%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR-RGLAARG 111
Q + + +D L E G+ ++ +E R+L Q E++ERL+Q + + R L +
Sbjct: 119 QRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS-EKQERLEQRDRQRRDEELWRQR 177
Query: 112 AEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQ-- 169
EW+ R E + E L++ G + E D + R R L EL + QQ + Q
Sbjct: 178 QEWQERE-ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDR 236
Query: 170 ------------------------TEQELQRELDALRGQCQAQALAGAELR-------TR 198
E+E QR+ + + Q + L ELR +
Sbjct: 237 VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQ 296
Query: 199 LESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERA 258
+ L+ E Q+ + + ++ Q RE+ E+ E + + ++L + ERRE L E+
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 259 RSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDT 318
+ L + +RR +L E +L+ Q L Q +
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQ-----LRREQ 411
Query: 319 PTTRSPKTRKASSPQPSPPEE---------------ILEPPKKRTSLSPAEILEEKEVEV 363
R + R+ + EE E ++R L E E E E
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 364 AKLQ---------DEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKA 414
K Q E L+ E + ++ +R+++LR +++ + +E + +
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531
Query: 415 LELSLQLNRVSLER--DSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKEL 472
L QL R ER L RE + + Q+ Q L+ Q++ + + ++ +RQ+ L
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQE-RREQRLKREQEERRDQLLKREEERRQQRL 590
Query: 473 SASASSSTPRR 483
+R
Sbjct: 591 KREQEERLEQR 601
Score = 63.5 bits (153), Expect = 4e-10
Identities = 135/515 (26%), Positives = 203/515 (39%), Gaps = 94/515 (18%)
Query: 32 ERRDSFLGGGPGPEEPEDLALQLQQKEKDLLLAAELGKMLLERNEE------LRRQLETL 85
ERR+ L + E+ L+ +++E+ L E + L + EE L+R+ E
Sbjct: 544 ERREQLL------KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 86 SAQHLERE--ERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSG 143
Q L+RE ERL+QE +R L E E R L+ + + R Q + R EQQ+
Sbjct: 598 LEQRLKREEVERLEQEERREQR-LKREEPEEERRQQLLKSEEQEERRQ-QQLRREQQERR 655
Query: 144 RERARALSELS--EQNL-------RLSQQLAQASQTEQ-------------ELQRELDAL 181
+R + E EQ L R Q+LA+ Q + +L+ E DA
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 182 RGQC---------QAQALAGAELRTRLES-LQGENQMLQSRRQDLEAQIRGL------RE 225
+ + Q + E R R ES LQ + + R+Q E Q R E
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775
Query: 226 EVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEAL-----SALRRLQRRVSE-- 278
+ E+G RL RE+RE L E + L RR QRR E
Sbjct: 776 KSERGRQRLSARPP-----LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE 830
Query: 279 ---LEEESRLQDADVSAASLQSELAHSLDDGD----QGQGADAPGDTPTTRSPKTRK--- 328
LEEE +LQ + A LQ E +D + Q Q D K R+
Sbjct: 831 LQFLEEEEQLQRRE-RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889
Query: 329 ----ASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREEL 384
A Q +++L+ ++ E +E E + ++E LQQ E Q LREE
Sbjct: 890 YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE-RQYREEEQLQQEEEQLLREE- 947
Query: 385 QRQKELRAQEDPGEALHSALSDRDEAV------NKALELSLQLNRVSLERDSLSRELLRA 438
R+K R + + L ++E + + + + R E +LLR
Sbjct: 948 -REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006
Query: 439 IRQKVALTQELEAW---QDDMQVVIGQQLRSQRQK 470
R+K QE E +D++Q Q LR +R+K
Sbjct: 1007 EREK-RRRQEWERQYRKKDELQQEEEQLLREEREK 1040
Score = 62.8 bits (151), Expect = 7e-10
Identities = 111/432 (25%), Positives = 175/432 (40%), Gaps = 64/432 (14%)
Query: 44 PEEPEDLALQLQQKEKDLLLAAELGKMLL-ERNEELRRQLETLSAQHLEREERLQQENHE 102
PEE E L + Q++ K ++ K LL E EE RR+ ET + EE+L QE E
Sbjct: 1294 PEE-EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET--DRKFREEEQLLQEREE 1350
Query: 103 --LRRGLAARGAEWEARAVELEG-----DVEALRAQLGEQR---SEQQDSGRERARALSE 152
LRR R E + +G + + LR Q E++ EQQ +ER + L +
Sbjct: 1351 QPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410
Query: 153 LSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLE---SLQGENQML 209
++ R +Q + +++ + E +R Q + + E + R E + E Q+L
Sbjct: 1411 DRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470
Query: 210 QSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRER----REHSLELERARSEAGEA 265
Q R + +++ + E + EE L R+ER RE L + + E
Sbjct: 1471 QEREE----------QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE 1520
Query: 266 LSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPK 325
L R QR+ L+EE +L+ ++GQ D +
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQ------------------ERGQQRRQDRDRKFREEEQ 1562
Query: 326 TRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE-LQSLREEL 384
R+ Q +E + R + + +E E ++DE L++ E Q LR+E
Sbjct: 1563 LRQEREEQQLSRQE-----RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 385 Q---RQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQ 441
R+ E QE + LH R E K LE QL R E+ L + R R+
Sbjct: 1618 DRKFREDEQLLQEREEQQLH-----RQERDRKFLEEEPQLRRQEREQ-QLRHDRDRKFRE 1671
Query: 442 KVALTQELEAWQ 453
+ L QE E Q
Sbjct: 1672 EEQLLQEGEEQQ 1683
Score = 54.3 bits (129), Expect = 3e-07
Identities = 99/427 (23%), Positives = 169/427 (39%), Gaps = 29/427 (6%)
Query: 74 RNEELRRQLETLSAQHLERE--ERLQQENHELRRGLAARGAEWEARAVELEG-DVEALRA 130
R EE +R+ E Q LE E +R +Q+ E R LA G E + LE D +
Sbjct: 114 RQEEDQRRFEPRDRQ-LEEEPGQRRRQKRQEQERELA-EGEEQSEKQERLEQRDRQRRDE 171
Query: 131 QLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQAL 190
+L QR E Q+ RE RA E + + + EQ +REL LR + + +
Sbjct: 172 ELWRQRQEWQE--REERRAEEEQLQSCK--GHETEEFPDEEQLRRRELLELRRKGREEKQ 227
Query: 191 AGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERRE 250
R + E + + R L + L+EE + + LQ E+L L R+
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ--- 284
Query: 251 HSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQ 310
EL R R E + LRR Q+ + EEE R Q + + E + +
Sbjct: 285 ---ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341
Query: 311 GADAPGDTPTTR-SPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAK---L 366
+ + R + R+ + EE E +R E +E ++ + L
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 367 QDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSL 426
+ E L++ + ++L+R+++LR +++ +R E ++ +L R
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQE---------EERHEQKHEQERREQRLKREQE 452
Query: 427 E-RDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAA 485
E RD L RE ++ Q+L+ Q++ + +L + ++E R
Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 486 PRFSLRL 492
R RL
Sbjct: 513 ERREQRL 519
Score = 53.1 bits (126), Expect = 6e-07
Identities = 95/404 (23%), Positives = 152/404 (37%), Gaps = 48/404 (11%)
Query: 75 NEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGE 134
+ +LR + QHL E++ + E RR W+ R + + R + E
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRR--------WQQRDRHFPEEEQLEREEQKE 1306
Query: 135 QRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQ-RELDALRGQCQAQALAGA 193
+ + S E+ + L E E+ R + + + EQ LQ RE LR Q + +
Sbjct: 1307 AKRRDRKSQEEK-QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREE 1365
Query: 194 ELRTRLESLQGENQMLQSRRQDL-------EAQIRGLREEVEKGEGRLQTTHEELLLLRR 246
ELR + + + + + RRQ+ E Q+R E + + R + EE L R
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425
Query: 247 ERREHSL----------ELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQ 296
+ R+ E ER E + L R +R EEE LQ+ + Q
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQL----RQERHRKFREEEQLLQEREEQQLHRQ 1481
Query: 297 SELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILE-------PPKKRTS 349
L++ Q + + R K R+ P + LE ++R
Sbjct: 1482 ERDRKFLEEEQQLRRQE--------RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF 1533
Query: 350 LSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDE 409
L + L +E + QD + E + LR+E + Q+ R + D L R E
Sbjct: 1534 LQEEQQLRRQERGQQRRQDR-DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592
Query: 410 AVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQ 453
K +E QL R + L +E R R+ L QE E Q
Sbjct: 1593 QERKFMEDEQQLRRQE-GQQQLRQERDRKFREDEQLLQEREEQQ 1635
Score = 49.3 bits (116), Expect = 8e-06
Identities = 80/354 (22%), Positives = 145/354 (40%), Gaps = 26/354 (7%)
Query: 126 EALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQC 185
E RA+ + S QD +E + E ++ L + + Q QE +REL Q
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLE-EEPGQRRRQKRQEQERELAEGEEQS 155
Query: 186 QAQA-LAGAELRTRLESLQGENQMLQSR--RQDLEAQIRGLR-EEVEKGEGRLQTTHEEL 241
+ Q L + + R E L + Q Q R R+ E Q++ + E E+ Q EL
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 242 LLLRRERREHSLELERARSEAGEALSALRRLQRRVSEL-EEESRLQDADVSAASLQSELA 300
L LRR+ RE + R R + + ++R + L +EE +LQ+ + E
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 301 HSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKE 360
L ++ Q + + R+ + EE E ++R +E+
Sbjct: 276 EQLRKLER-QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 361 VEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQ 420
E +++ ++ +L+ +EE +R+++LR +++ +E + L Q
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLRREQE------------EERREQQLRREQQ 382
Query: 421 LNRVSLERDSLSRELLRAIRQKVALTQELEAWQD---DMQVVIGQQLRSQRQKE 471
L R L RE Q++ Q+L Q + Q+ QQLR ++++E
Sbjct: 383 LRR----EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Score = 40.8 bits (94), Expect = 0.003
Identities = 46/190 (24%), Positives = 77/190 (40%), Gaps = 36/190 (18%)
Query: 47 PEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRG 106
PE QL+++E+D E ++ ER E+ R E S + EE+L+QE E +
Sbjct: 1757 PEREEQQLRRQERDRKFREE-EQLRQEREEQQLRSQE--SDRKFREEEQLRQEREEQQLR 1813
Query: 107 LAARGAE--WEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
R + WE ++LE EQR Q+ + RA E++ R Q+L
Sbjct: 1814 PQQRDGKYRWEEEQLQLE---------EQEQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864
Query: 165 AQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLR 224
Q + ++ +RE L+ E+ Q + + Q+ ++
Sbjct: 1865 WQEEEQKRRQERE----------------------RKLREEHIRRQQKEEQRHRQVGEIK 1902
Query: 225 EEVEKGEGRL 234
+ KG GRL
Sbjct: 1903 SQEGKGHGRL 1912
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 82.4 bits (202), Expect = 9e-16
Identities = 107/477 (22%), Positives = 189/477 (39%), Gaps = 58/477 (12%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE E LA Q + +E++ L E LE+ +L + H + + + ++E EL+
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAA---LEKQRQL-------AEAHAQAKAQAEREAKELQ 1394
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
+ + E AV+ + +++ +L + R + + +AR LR+ +++
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 165 ----AQASQTEQE---LQRELDALRG---QCQAQALAGAELRTRL-ESLQGENQMLQSRR 213
Q TE++ + EL ALR + +AQ E RL +Q E+Q +
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHE-ELLLLRRERREHSLELERARSEAGEALSALRRL 272
+L ++++ E + + LQ E L ERR E+ERAR + AL
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETA 1570
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDD---------GDQGQGADAPGDTPTTRS 323
QR E+ LQ S A ++L SL + + + A + R
Sbjct: 1571 QR-----SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 324 PKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK---EVEVAKLQDEISLQQAELQSL 380
R+ Q E + R L E+ ++K + E K ++E +
Sbjct: 1626 EAERELERWQLKANEAL------RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 381 REELQRQKELRAQ--EDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRA 438
E+ RQ+EL Q E + R A + + L + + +R L EL R
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 439 IRQKVALTQ-------ELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRF 488
R+ A TQ EL + +M+V++ + R++ + ++ S A RF
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796
Score = 74.3 bits (181), Expect = 2e-13
Identities = 110/463 (23%), Positives = 196/463 (42%), Gaps = 44/463 (9%)
Query: 45 EEPEDLALQLQQKEKDLLLAA-ELGKMLLERNEELRRQLETLSAQHLEREERLQQENHEL 103
EE E A Q + E+ A EL + L+ NE LR +L+ A+ + +++ L Q E
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEK 1664
Query: 104 RRGLAARGAEWEARAVELEGDVEALRAQ-LGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
++ A R A +A E L Q L +QR + + ++R A EL +RL
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRA 1720
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+ Q Q Q L+ EL L+ + A EL L ++ E ++L + + E + R
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 223 LREE----VEKGEGRLQTTHEELLLLRRERREHSLELERARSEAG-EALSALRRLQRRVS 277
E+ +E GR + EE LR E + + A +A + A R L +++
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 278 ELEEESRLQ-DADVSAASLQSE---LAHSLDDGD------QGQGADAPGDTPTTRSPKTR 327
+ E +RL+ +A+++ ++E L +D + Q A D R + R
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLAQLR 1899
Query: 328 KASSPQPSPPEEILEPPKKRTSLSPAEILE-------------EKEVEVAKLQDEI---- 370
KAS + + ++E ++ EIL E E+E+ +++
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 371 -SLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERD 429
S +QAEL++ R+ +E R + + E + +L+ +EA + ++ R+ + +
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 430 SLSRELLRAIRQKVALTQ-ELEAWQDDMQVVIGQQLRSQRQKE 471
R RA ++ Q EA Q +Q + +QKE
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Score = 67.8 bits (164), Expect = 2e-11
Identities = 105/424 (24%), Positives = 166/424 (39%), Gaps = 41/424 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQL--ETLSAQH-LEREERLQQENHELRRGLAA 109
+L Q++K+L A E + L E E++ +QL ET Q LE E + Q E L
Sbjct: 2330 ELLQQQKEL--AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2387
Query: 110 RGAEWEARAVELEGDVEALRAQ---LGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQ 166
R AE E D + R Q +GE+ + + +E+ + L Q + +
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 167 ASQTEQELQRELDALRGQCQAQALAGAELRT-RLESLQGENQMLQ----SRRQDLEAQIR 221
+ EL+RE + L+ + + L E++T + E L E Q LQ S + L + R
Sbjct: 2448 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2507
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRE--RREHSLELER---------ARSEAGEALSALR 270
+ +E K E Q + LR E R++ +E ER AR EA +R
Sbjct: 2508 FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Query: 271 RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 330
R Q + +LE++ R Q+ A L L ++ A T S +
Sbjct: 2568 RKQEELQQLEQQRRQQEE--LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 331 SPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL 390
P + L+ P + ++V +LQ+ L ELQ L + EL
Sbjct: 2626 LPN---GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682
Query: 391 RAQEDPGEALHSALSDRD---EAVNKALELSLQLNR---------VSLERDSLSRELLRA 438
+ED L S +A N+ L + L R + LE + S LL
Sbjct: 2683 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2742
Query: 439 IRQK 442
+R +
Sbjct: 2743 VRNR 2746
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/442 (23%), Positives = 179/442 (40%), Gaps = 39/442 (8%)
Query: 48 EDLALQLQQKEKDLLLA-AELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR- 105
E+ Q Q E+D AE ++L E+ + + + +E+ + EN LRR
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRL 1869
Query: 106 --GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE--------LSE 155
A + E +A + + D+E AQL + DS ER + L E + E
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQL----RKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 156 QNLRLSQQLAQASQTEQELQRELDALRGQCQ--AQALAGAELRT-RLESLQGENQMLQSR 212
+ L L +A+ + EL+ EL +R + ++ AEL R L E + R
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER---R 1982
Query: 213 RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL 272
R++ E +++ E+ + + EE+ L+ + E ERA E+ L +
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSP 332
++ + EE++ LQ L DQ +G R A
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG---------EAEAARRAAEEA 2093
Query: 333 QPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRA 392
+ + + E + R + AE L++ E A+ + + QA + LR+E +++ RA
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ---AQAAAEKLRKEAEQEAARRA 2150
Query: 393 QEDPGEALHSALSDRD-EAVNKALELSL-QLNRVSLERDSLSRELLRAIRQKVALTQELE 450
Q + +D + E K E +L Q +V E +L +L QK L +EL+
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Query: 451 AWQDDMQVVIGQQLRSQRQKEL 472
+ + Q RSQ ++EL
Sbjct: 2211 RLKAEATEAARQ--RSQVEEEL 2230
Score = 59.3 bits (142), Expect = 8e-09
Identities = 105/500 (21%), Positives = 188/500 (37%), Gaps = 98/500 (19%)
Query: 56 QKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWE 115
++ K L E K +E LR + E SA+ L+ + Q+ + AE +
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ---------AEEK 2052
Query: 116 ARAVELEGDVEALRAQLGEQRS---EQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
A A ++ + L+ L +++S + + RA E E ++ ++ AQ+ + +
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 173 ELQRELDALRGQCQAQALAGA---ELRTRLES-----LQGENQMLQSR------------ 212
E +R + Q QA+A A A +LR E Q E L+ +
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 213 --------RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ +E ++ LR ++E+ + + EEL L+ E E + + + E
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 265 ALSALRRLQRRVSELEEESR---LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT 321
+ L + + +E E+R L+D D + LQ E ++
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE----- 376
+ + Q + E++L+ +K ++ A L + E E+ + Q E++ +QA
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLK--EKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQED 2349
Query: 377 ----LQSLREELQ---------RQKEL---------------------RAQEDP------ 396
Q L EE Q RQ++L RA+ED
Sbjct: 2350 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2409
Query: 397 ----GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQE---L 449
GE LH E V L +Q + + + L + R+K L QE L
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 450 EAWQDDMQVVIGQQLRSQRQ 469
+ ++MQ V +QL + Q
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQ 2489
Score = 58.5 bits (140), Expect = 1e-08
Identities = 97/473 (20%), Positives = 188/473 (39%), Gaps = 36/473 (7%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E +D+ LQL+ E + ++ L ++E R+ AQ + +++ Q E L +
Sbjct: 988 ELKDIRLQLEACE-----TRTVHRLRLPLDKEPAREC----AQRIAEQQKAQAEVEGLGK 1038
Query: 106 GLAARGAEWEA---------RAVELEGDVEALRAQLGEQRS------EQQDS------GR 144
G+A AE E A L ++E +L + RS E+ + G
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098
Query: 145 ERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQG 204
+ A + E+ L+ +Q + + + L LR Q +AQ LR L Q
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 205 ENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ LQ R + + ++ RE V + R Q + + +RE + +L R E+ +
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR-ESAD 1217
Query: 265 ALSALRRLQRRVSELEEESRLQDADVSAASLQSE---LAHSLDDGDQGQGADAPGDTPTT 321
L A + RR E + L D+ L+ E L G++ +
Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEI-SLQQAELQSL 380
+ E + P KK S +E + ++ V++ E+ +L ++ +
Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337
Query: 381 REELQR-QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAI 439
E L+R ++E R E L++ + A+ K +L+ + + + ++EL + +
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 440 RQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRL 492
+++V +E + I ++L+ RQ + + + AA R LR+
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Score = 52.0 bits (123), Expect = 1e-06
Identities = 103/421 (24%), Positives = 166/421 (39%), Gaps = 55/421 (13%)
Query: 75 NEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRA-QLG 133
N+E + + L AQH Q + +++ LA W++ L DV+ +R+ L
Sbjct: 862 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLA-----WQS----LRRDVQLIRSWSLA 912
Query: 134 EQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGA 193
R+ + + R+ +L EL Q Q A E L E + G C
Sbjct: 913 TFRTLKPEEQRQALHSL-ELHYQAFLRDSQDAGGFGPEDRLMAEREY--GSCSHH----- 964
Query: 194 ELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRE-RREHS 252
+ L+SL+ + +SR Q ++++ +R ++E E R T H L L +E RE +
Sbjct: 965 -YQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETR--TVHRLRLPLDKEPARECA 1020
Query: 253 LELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGA 312
+ + E + + R +E E+ L + +A +L+SEL +L +Q +
Sbjct: 1021 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1080
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEIL---EPPKKRTSLSPAEI--LEEKEVEVAKLQ 367
A KT EE+L E K PA + LE + + KL+
Sbjct: 1081 SAI----YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1136
Query: 368 DEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQL----NR 423
+ QQ +LR+EL R ++ GE L +RD V + E QL
Sbjct: 1137 AQAEAQQPTFDALRDEL------RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1190
Query: 424 VSLERDSLSRELL---RAIRQKVALTQELEAWQDD----------MQVVIGQQLRSQRQK 470
V + D REL R +R L AW D M + Q +R Q ++
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250
Query: 471 E 471
E
Sbjct: 1251 E 1251
Score = 32.7 bits (73), Expect = 0.80
Identities = 59/232 (25%), Positives = 98/232 (42%), Gaps = 32/232 (13%)
Query: 66 ELGKM---LLERNEELRRQLETLSAQHLER-EERLQQENHELRRGLAARGAEWEARAVEL 121
E GK+ +LER ++LR + E L L+R +LQ E GL +A A+ L
Sbjct: 369 EWGKLHVAILEREKQLRSEFERLEC--LQRIVTKLQME-----AGLCEEQLN-QADAL-L 419
Query: 122 EGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ-----QLAQASQTEQELQR 176
+ DV L A QR+ + + ++A ++ L +++ + Q Q + L
Sbjct: 420 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 479
Query: 177 ELDALRGQCQAQALAGAEL------RTRLESLQGENQMLQSRR---QDLEAQIRGLREEV 227
L A+R + + AG + L+S+Q ++ S QDL A + + V
Sbjct: 480 RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV 539
Query: 228 EKGEGRLQTTHEELLL-----LRRERREHSLELERARSEAGEALSALRRLQR 274
+ E + E L L + E ++ERARS+ G+ A R R
Sbjct: 540 DGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR 591
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 82.4 bits (202), Expect = 9e-16
Identities = 107/477 (22%), Positives = 189/477 (39%), Gaps = 58/477 (12%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE E LA Q + +E++ L E LE+ +L + H + + + ++E EL+
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAA---LEKQRQL-------AEAHAQAKAQAEREAKELQ 1398
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
+ + E AV+ + +++ +L + R + + +AR LR+ +++
Sbjct: 1399 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458
Query: 165 ----AQASQTEQE---LQRELDALRG---QCQAQALAGAELRTRL-ESLQGENQMLQSRR 213
Q TE++ + EL ALR + +AQ E RL +Q E+Q +
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1518
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHE-ELLLLRRERREHSLELERARSEAGEALSALRRL 272
+L ++++ E + + LQ E L ERR E+ERAR + AL
Sbjct: 1519 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETA 1574
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDD---------GDQGQGADAPGDTPTTRS 323
QR E+ LQ S A ++L SL + + + A + R
Sbjct: 1575 QR-----SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629
Query: 324 PKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK---EVEVAKLQDEISLQQAELQSL 380
R+ Q E + R L E+ ++K + E K ++E +
Sbjct: 1630 EAERELERWQLKANEAL------RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683
Query: 381 REELQRQKELRAQ--EDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRA 438
E+ RQ+EL Q E + R A + + L + + +R L EL R
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1743
Query: 439 IRQKVALTQ-------ELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRF 488
R+ A TQ EL + +M+V++ + R++ + ++ S A RF
Sbjct: 1744 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1800
Score = 74.3 bits (181), Expect = 2e-13
Identities = 110/463 (23%), Positives = 196/463 (42%), Gaps = 44/463 (9%)
Query: 45 EEPEDLALQLQQKEKDLLLAA-ELGKMLLERNEELRRQLETLSAQHLEREERLQQENHEL 103
EE E A Q + E+ A EL + L+ NE LR +L+ A+ + +++ L Q E
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEK 1668
Query: 104 RRGLAARGAEWEARAVELEGDVEALRAQ-LGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
++ A R A +A E L Q L +QR + + ++R A EL +RL
Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRA 1724
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+ Q Q Q L+ EL L+ + A EL L ++ E ++L + + E + R
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 223 LREE----VEKGEGRLQTTHEELLLLRRERREHSLELERARSEAG-EALSALRRLQRRVS 277
E+ +E GR + EE LR E + + A +A + A R L +++
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844
Query: 278 ELEEESRLQ-DADVSAASLQSE---LAHSLDDGD------QGQGADAPGDTPTTRSPKTR 327
+ E +RL+ +A+++ ++E L +D + Q A D R + R
Sbjct: 1845 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLAQLR 1903
Query: 328 KASSPQPSPPEEILEPPKKRTSLSPAEILE-------------EKEVEVAKLQDEI---- 370
KAS + + ++E ++ EIL E E+E+ +++
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963
Query: 371 -SLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERD 429
S +QAEL++ R+ +E R + + E + +L+ +EA + ++ R+ + +
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2023
Query: 430 SLSRELLRAIRQKVALTQ-ELEAWQDDMQVVIGQQLRSQRQKE 471
R RA ++ Q EA Q +Q + +QKE
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066
Score = 67.8 bits (164), Expect = 2e-11
Identities = 105/424 (24%), Positives = 166/424 (39%), Gaps = 41/424 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQL--ETLSAQH-LEREERLQQENHELRRGLAA 109
+L Q++K+L A E + L E E++ +QL ET Q LE E + Q E L
Sbjct: 2334 ELLQQQKEL--AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2391
Query: 110 RGAEWEARAVELEGDVEALRAQ---LGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQ 166
R AE E D + R Q +GE+ + + +E+ + L Q + +
Sbjct: 2392 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2451
Query: 167 ASQTEQELQRELDALRGQCQAQALAGAELRT-RLESLQGENQMLQ----SRRQDLEAQIR 221
+ EL+RE + L+ + + L E++T + E L E Q LQ S + L + R
Sbjct: 2452 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2511
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRE--RREHSLELER---------ARSEAGEALSALR 270
+ +E K E Q + LR E R++ +E ER AR EA +R
Sbjct: 2512 FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571
Query: 271 RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 330
R Q + +LE++ R Q+ A L L ++ A T S +
Sbjct: 2572 RKQEELQQLEQQRRQQEE--LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2629
Query: 331 SPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL 390
P + L+ P + ++V +LQ+ L ELQ L + EL
Sbjct: 2630 LPN---GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2686
Query: 391 RAQEDPGEALHSALSDRD---EAVNKALELSLQLNR---------VSLERDSLSRELLRA 438
+ED L S +A N+ L + L R + LE + S LL
Sbjct: 2687 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2746
Query: 439 IRQK 442
+R +
Sbjct: 2747 VRNR 2750
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/442 (23%), Positives = 179/442 (40%), Gaps = 39/442 (8%)
Query: 48 EDLALQLQQKEKDLLLA-AELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR- 105
E+ Q Q E+D AE ++L E+ + + + +E+ + EN LRR
Sbjct: 1815 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRL 1873
Query: 106 --GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE--------LSE 155
A + E +A + + D+E AQL + DS ER + L E + E
Sbjct: 1874 AEDEAFQRRRLEEQAAQHKADIEERLAQL----RKASDSELERQKGLVEDTLRQRRQVEE 1929
Query: 156 QNLRLSQQLAQASQTEQELQRELDALRGQCQ--AQALAGAELRT-RLESLQGENQMLQSR 212
+ L L +A+ + EL+ EL +R + ++ AEL R L E + R
Sbjct: 1930 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER---R 1986
Query: 213 RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL 272
R++ E +++ E+ + + EE+ L+ + E ERA E+ L +
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSP 332
++ + EE++ LQ L DQ +G R A
Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG---------EAEAARRAAEEA 2097
Query: 333 QPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRA 392
+ + + E + R + AE L++ E A+ + + QA + LR+E +++ RA
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ---AQAAAEKLRKEAEQEAARRA 2154
Query: 393 QEDPGEALHSALSDRD-EAVNKALELSL-QLNRVSLERDSLSRELLRAIRQKVALTQELE 450
Q + +D + E K E +L Q +V E +L +L QK L +EL+
Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2214
Query: 451 AWQDDMQVVIGQQLRSQRQKEL 472
+ + Q RSQ ++EL
Sbjct: 2215 RLKAEATEAARQ--RSQVEEEL 2234
Score = 59.3 bits (142), Expect = 8e-09
Identities = 105/500 (21%), Positives = 188/500 (37%), Gaps = 98/500 (19%)
Query: 56 QKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWE 115
++ K L E K +E LR + E SA+ L+ + Q+ + AE +
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ---------AEEK 2056
Query: 116 ARAVELEGDVEALRAQLGEQRS---EQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
A A ++ + L+ L +++S + + RA E E ++ ++ AQ+ + +
Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2116
Query: 173 ELQRELDALRGQCQAQALAGA---ELRTRLES-----LQGENQMLQSR------------ 212
E +R + Q QA+A A A +LR E Q E L+ +
Sbjct: 2117 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2176
Query: 213 --------RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ +E ++ LR ++E+ + + EEL L+ E E + + + E
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236
Query: 265 ALSALRRLQRRVSELEEESR---LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT 321
+ L + + +E E+R L+D D + LQ E ++
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE----- 376
+ + Q + E++L+ +K ++ A L + E E+ + Q E++ +QA
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLK--EKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQED 2353
Query: 377 ----LQSLREELQ---------RQKEL---------------------RAQEDP------ 396
Q L EE Q RQ++L RA+ED
Sbjct: 2354 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2413
Query: 397 ----GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQE---L 449
GE LH E V L +Q + + + L + R+K L QE L
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 450 EAWQDDMQVVIGQQLRSQRQ 469
+ ++MQ V +QL + Q
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQ 2493
Score = 58.5 bits (140), Expect = 1e-08
Identities = 97/473 (20%), Positives = 188/473 (39%), Gaps = 36/473 (7%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E +D+ LQL+ E + ++ L ++E R+ AQ + +++ Q E L +
Sbjct: 992 ELKDIRLQLEACE-----TRTVHRLRLPLDKEPAREC----AQRIAEQQKAQAEVEGLGK 1042
Query: 106 GLAARGAEWEA---------RAVELEGDVEALRAQLGEQRS------EQQDS------GR 144
G+A AE E A L ++E +L + RS E+ + G
Sbjct: 1043 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1102
Query: 145 ERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQG 204
+ A + E+ L+ +Q + + + L LR Q +AQ LR L Q
Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1162
Query: 205 ENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ LQ R + + ++ RE V + R Q + + +RE + +L R E+ +
Sbjct: 1163 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR-ESAD 1221
Query: 265 ALSALRRLQRRVSELEEESRLQDADVSAASLQSE---LAHSLDDGDQGQGADAPGDTPTT 321
L A + RR E + L D+ L+ E L G++ +
Sbjct: 1222 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1281
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEI-SLQQAELQSL 380
+ E + P KK S +E + ++ V++ E+ +L ++ +
Sbjct: 1282 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1341
Query: 381 REELQR-QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAI 439
E L+R ++E R E L++ + A+ K +L+ + + + ++EL + +
Sbjct: 1342 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1401
Query: 440 RQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRL 492
+++V +E + I ++L+ RQ + + + AA R LR+
Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1454
Score = 52.0 bits (123), Expect = 1e-06
Identities = 103/421 (24%), Positives = 166/421 (39%), Gaps = 55/421 (13%)
Query: 75 NEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRA-QLG 133
N+E + + L AQH Q + +++ LA W++ L DV+ +R+ L
Sbjct: 866 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLA-----WQS----LRRDVQLIRSWSLA 916
Query: 134 EQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGA 193
R+ + + R+ +L EL Q Q A E L E + G C
Sbjct: 917 TFRTLKPEEQRQALHSL-ELHYQAFLRDSQDAGGFGPEDRLMAEREY--GSCSHH----- 968
Query: 194 ELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRE-RREHS 252
+ L+SL+ + +SR Q ++++ +R ++E E R T H L L +E RE +
Sbjct: 969 -YQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETR--TVHRLRLPLDKEPARECA 1024
Query: 253 LELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGA 312
+ + E + + R +E E+ L + +A +L+SEL +L +Q +
Sbjct: 1025 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1084
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEIL---EPPKKRTSLSPAEI--LEEKEVEVAKLQ 367
A KT EE+L E K PA + LE + + KL+
Sbjct: 1085 SAI----YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1140
Query: 368 DEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQL----NR 423
+ QQ +LR+EL R ++ GE L +RD V + E QL
Sbjct: 1141 AQAEAQQPTFDALRDEL------RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1194
Query: 424 VSLERDSLSRELL---RAIRQKVALTQELEAWQDD----------MQVVIGQQLRSQRQK 470
V + D REL R +R L AW D M + Q +R Q ++
Sbjct: 1195 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1254
Query: 471 E 471
E
Sbjct: 1255 E 1255
Score = 32.7 bits (73), Expect = 0.80
Identities = 59/232 (25%), Positives = 98/232 (42%), Gaps = 32/232 (13%)
Query: 66 ELGKM---LLERNEELRRQLETLSAQHLER-EERLQQENHELRRGLAARGAEWEARAVEL 121
E GK+ +LER ++LR + E L L+R +LQ E GL +A A+ L
Sbjct: 373 EWGKLHVAILEREKQLRSEFERLEC--LQRIVTKLQME-----AGLCEEQLN-QADAL-L 423
Query: 122 EGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ-----QLAQASQTEQELQR 176
+ DV L A QR+ + + ++A ++ L +++ + Q Q + L
Sbjct: 424 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 483
Query: 177 ELDALRGQCQAQALAGAEL------RTRLESLQGENQMLQSRR---QDLEAQIRGLREEV 227
L A+R + + AG + L+S+Q ++ S QDL A + + V
Sbjct: 484 RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV 543
Query: 228 EKGEGRLQTTHEELLL-----LRRERREHSLELERARSEAGEALSALRRLQR 274
+ E + E L L + E ++ERARS+ G+ A R R
Sbjct: 544 DGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR 595
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 82.4 bits (202), Expect = 9e-16
Identities = 107/477 (22%), Positives = 189/477 (39%), Gaps = 58/477 (12%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE E LA Q + +E++ L E LE+ +L + H + + + ++E EL+
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAA---LEKQRQL-------AEAHAQAKAQAEREAKELQ 1394
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
+ + E AV+ + +++ +L + R + + +AR LR+ +++
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 165 ----AQASQTEQE---LQRELDALRG---QCQAQALAGAELRTRL-ESLQGENQMLQSRR 213
Q TE++ + EL ALR + +AQ E RL +Q E+Q +
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHE-ELLLLRRERREHSLELERARSEAGEALSALRRL 272
+L ++++ E + + LQ E L ERR E+ERAR + AL
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETA 1570
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDD---------GDQGQGADAPGDTPTTRS 323
QR E+ LQ S A ++L SL + + + A + R
Sbjct: 1571 QR-----SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 324 PKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK---EVEVAKLQDEISLQQAELQSL 380
R+ Q E + R L E+ ++K + E K ++E +
Sbjct: 1626 EAERELERWQLKANEAL------RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 381 REELQRQKELRAQ--EDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRA 438
E+ RQ+EL Q E + R A + + L + + +R L EL R
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 439 IRQKVALTQ-------ELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRF 488
R+ A TQ EL + +M+V++ + R++ + ++ S A RF
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796
Score = 74.3 bits (181), Expect = 2e-13
Identities = 110/463 (23%), Positives = 196/463 (42%), Gaps = 44/463 (9%)
Query: 45 EEPEDLALQLQQKEKDLLLAA-ELGKMLLERNEELRRQLETLSAQHLEREERLQQENHEL 103
EE E A Q + E+ A EL + L+ NE LR +L+ A+ + +++ L Q E
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEK 1664
Query: 104 RRGLAARGAEWEARAVELEGDVEALRAQ-LGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
++ A R A +A E L Q L +QR + + ++R A EL +RL
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRA 1720
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+ Q Q Q L+ EL L+ + A EL L ++ E ++L + + E + R
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 223 LREE----VEKGEGRLQTTHEELLLLRRERREHSLELERARSEAG-EALSALRRLQRRVS 277
E+ +E GR + EE LR E + + A +A + A R L +++
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 278 ELEEESRLQ-DADVSAASLQSE---LAHSLDDGD------QGQGADAPGDTPTTRSPKTR 327
+ E +RL+ +A+++ ++E L +D + Q A D R + R
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLAQLR 1899
Query: 328 KASSPQPSPPEEILEPPKKRTSLSPAEILE-------------EKEVEVAKLQDEI---- 370
KAS + + ++E ++ EIL E E+E+ +++
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 371 -SLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERD 429
S +QAEL++ R+ +E R + + E + +L+ +EA + ++ R+ + +
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 430 SLSRELLRAIRQKVALTQ-ELEAWQDDMQVVIGQQLRSQRQKE 471
R RA ++ Q EA Q +Q + +QKE
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Score = 67.8 bits (164), Expect = 2e-11
Identities = 105/424 (24%), Positives = 166/424 (39%), Gaps = 41/424 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQL--ETLSAQH-LEREERLQQENHELRRGLAA 109
+L Q++K+L A E + L E E++ +QL ET Q LE E + Q E L
Sbjct: 2330 ELLQQQKEL--AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2387
Query: 110 RGAEWEARAVELEGDVEALRAQ---LGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQ 166
R AE E D + R Q +GE+ + + +E+ + L Q + +
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 167 ASQTEQELQRELDALRGQCQAQALAGAELRT-RLESLQGENQMLQ----SRRQDLEAQIR 221
+ EL+RE + L+ + + L E++T + E L E Q LQ S + L + R
Sbjct: 2448 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2507
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRE--RREHSLELER---------ARSEAGEALSALR 270
+ +E K E Q + LR E R++ +E ER AR EA +R
Sbjct: 2508 FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Query: 271 RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 330
R Q + +LE++ R Q+ A L L ++ A T S +
Sbjct: 2568 RKQEELQQLEQQRRQQEE--LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 331 SPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL 390
P + L+ P + ++V +LQ+ L ELQ L + EL
Sbjct: 2626 LPN---GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682
Query: 391 RAQEDPGEALHSALSDRD---EAVNKALELSLQLNR---------VSLERDSLSRELLRA 438
+ED L S +A N+ L + L R + LE + S LL
Sbjct: 2683 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2742
Query: 439 IRQK 442
+R +
Sbjct: 2743 VRNR 2746
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/442 (23%), Positives = 179/442 (40%), Gaps = 39/442 (8%)
Query: 48 EDLALQLQQKEKDLLLA-AELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR- 105
E+ Q Q E+D AE ++L E+ + + + +E+ + EN LRR
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRL 1869
Query: 106 --GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE--------LSE 155
A + E +A + + D+E AQL + DS ER + L E + E
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQL----RKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 156 QNLRLSQQLAQASQTEQELQRELDALRGQCQ--AQALAGAELRT-RLESLQGENQMLQSR 212
+ L L +A+ + EL+ EL +R + ++ AEL R L E + R
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER---R 1982
Query: 213 RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL 272
R++ E +++ E+ + + EE+ L+ + E ERA E+ L +
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSP 332
++ + EE++ LQ L DQ +G R A
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG---------EAEAARRAAEEA 2093
Query: 333 QPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRA 392
+ + + E + R + AE L++ E A+ + + QA + LR+E +++ RA
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ---AQAAAEKLRKEAEQEAARRA 2150
Query: 393 QEDPGEALHSALSDRD-EAVNKALELSL-QLNRVSLERDSLSRELLRAIRQKVALTQELE 450
Q + +D + E K E +L Q +V E +L +L QK L +EL+
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Query: 451 AWQDDMQVVIGQQLRSQRQKEL 472
+ + Q RSQ ++EL
Sbjct: 2211 RLKAEATEAARQ--RSQVEEEL 2230
Score = 59.3 bits (142), Expect = 8e-09
Identities = 105/500 (21%), Positives = 188/500 (37%), Gaps = 98/500 (19%)
Query: 56 QKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWE 115
++ K L E K +E LR + E SA+ L+ + Q+ + AE +
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ---------AEEK 2052
Query: 116 ARAVELEGDVEALRAQLGEQRS---EQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
A A ++ + L+ L +++S + + RA E E ++ ++ AQ+ + +
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 173 ELQRELDALRGQCQAQALAGA---ELRTRLES-----LQGENQMLQSR------------ 212
E +R + Q QA+A A A +LR E Q E L+ +
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 213 --------RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ +E ++ LR ++E+ + + EEL L+ E E + + + E
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 265 ALSALRRLQRRVSELEEESR---LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT 321
+ L + + +E E+R L+D D + LQ E ++
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE----- 376
+ + Q + E++L+ +K ++ A L + E E+ + Q E++ +QA
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLK--EKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQED 2349
Query: 377 ----LQSLREELQ---------RQKEL---------------------RAQEDP------ 396
Q L EE Q RQ++L RA+ED
Sbjct: 2350 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2409
Query: 397 ----GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQE---L 449
GE LH E V L +Q + + + L + R+K L QE L
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 450 EAWQDDMQVVIGQQLRSQRQ 469
+ ++MQ V +QL + Q
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQ 2489
Score = 58.5 bits (140), Expect = 1e-08
Identities = 97/473 (20%), Positives = 188/473 (39%), Gaps = 36/473 (7%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E +D+ LQL+ E + ++ L ++E R+ AQ + +++ Q E L +
Sbjct: 988 ELKDIRLQLEACE-----TRTVHRLRLPLDKEPAREC----AQRIAEQQKAQAEVEGLGK 1038
Query: 106 GLAARGAEWEA---------RAVELEGDVEALRAQLGEQRS------EQQDS------GR 144
G+A AE E A L ++E +L + RS E+ + G
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098
Query: 145 ERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQG 204
+ A + E+ L+ +Q + + + L LR Q +AQ LR L Q
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 205 ENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ LQ R + + ++ RE V + R Q + + +RE + +L R E+ +
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR-ESAD 1217
Query: 265 ALSALRRLQRRVSELEEESRLQDADVSAASLQSE---LAHSLDDGDQGQGADAPGDTPTT 321
L A + RR E + L D+ L+ E L G++ +
Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEI-SLQQAELQSL 380
+ E + P KK S +E + ++ V++ E+ +L ++ +
Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337
Query: 381 REELQR-QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAI 439
E L+R ++E R E L++ + A+ K +L+ + + + ++EL + +
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 440 RQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRL 492
+++V +E + I ++L+ RQ + + + AA R LR+
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Score = 52.0 bits (123), Expect = 1e-06
Identities = 103/421 (24%), Positives = 166/421 (39%), Gaps = 55/421 (13%)
Query: 75 NEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRA-QLG 133
N+E + + L AQH Q + +++ LA W++ L DV+ +R+ L
Sbjct: 862 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLA-----WQS----LRRDVQLIRSWSLA 912
Query: 134 EQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGA 193
R+ + + R+ +L EL Q Q A E L E + G C
Sbjct: 913 TFRTLKPEEQRQALHSL-ELHYQAFLRDSQDAGGFGPEDRLMAEREY--GSCSHH----- 964
Query: 194 ELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRE-RREHS 252
+ L+SL+ + +SR Q ++++ +R ++E E R T H L L +E RE +
Sbjct: 965 -YQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETR--TVHRLRLPLDKEPARECA 1020
Query: 253 LELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGA 312
+ + E + + R +E E+ L + +A +L+SEL +L +Q +
Sbjct: 1021 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1080
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEIL---EPPKKRTSLSPAEI--LEEKEVEVAKLQ 367
A KT EE+L E K PA + LE + + KL+
Sbjct: 1081 SAI----YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1136
Query: 368 DEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQL----NR 423
+ QQ +LR+EL R ++ GE L +RD V + E QL
Sbjct: 1137 AQAEAQQPTFDALRDEL------RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1190
Query: 424 VSLERDSLSRELL---RAIRQKVALTQELEAWQDD----------MQVVIGQQLRSQRQK 470
V + D REL R +R L AW D M + Q +R Q ++
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250
Query: 471 E 471
E
Sbjct: 1251 E 1251
Score = 32.7 bits (73), Expect = 0.80
Identities = 59/232 (25%), Positives = 98/232 (42%), Gaps = 32/232 (13%)
Query: 66 ELGKM---LLERNEELRRQLETLSAQHLER-EERLQQENHELRRGLAARGAEWEARAVEL 121
E GK+ +LER ++LR + E L L+R +LQ E GL +A A+ L
Sbjct: 369 EWGKLHVAILEREKQLRSEFERLEC--LQRIVTKLQME-----AGLCEEQLN-QADAL-L 419
Query: 122 EGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ-----QLAQASQTEQELQR 176
+ DV L A QR+ + + ++A ++ L +++ + Q Q + L
Sbjct: 420 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 479
Query: 177 ELDALRGQCQAQALAGAEL------RTRLESLQGENQMLQSRR---QDLEAQIRGLREEV 227
L A+R + + AG + L+S+Q ++ S QDL A + + V
Sbjct: 480 RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV 539
Query: 228 EKGEGRLQTTHEELLL-----LRRERREHSLELERARSEAGEALSALRRLQR 274
+ E + E L L + E ++ERARS+ G+ A R R
Sbjct: 540 DGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR 591
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 82.4 bits (202), Expect = 9e-16
Identities = 107/477 (22%), Positives = 189/477 (39%), Gaps = 58/477 (12%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE E LA Q + +E++ L E LE+ +L + H + + + ++E EL+
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAA---LEKQRQL-------AEAHAQAKAQAEREAKELQ 1362
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
+ + E AV+ + +++ +L + R + + +AR LR+ +++
Sbjct: 1363 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422
Query: 165 ----AQASQTEQE---LQRELDALRG---QCQAQALAGAELRTRL-ESLQGENQMLQSRR 213
Q TE++ + EL ALR + +AQ E RL +Q E+Q +
Sbjct: 1423 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1482
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHE-ELLLLRRERREHSLELERARSEAGEALSALRRL 272
+L ++++ E + + LQ E L ERR E+ERAR + AL
Sbjct: 1483 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETA 1538
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDD---------GDQGQGADAPGDTPTTRS 323
QR E+ LQ S A ++L SL + + + A + R
Sbjct: 1539 QR-----SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593
Query: 324 PKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK---EVEVAKLQDEISLQQAELQSL 380
R+ Q E + R L E+ ++K + E K ++E +
Sbjct: 1594 EAERELERWQLKANEAL------RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647
Query: 381 REELQRQKELRAQ--EDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRA 438
E+ RQ+EL Q E + R A + + L + + +R L EL R
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1707
Query: 439 IRQKVALTQ-------ELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRF 488
R+ A TQ EL + +M+V++ + R++ + ++ S A RF
Sbjct: 1708 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1764
Score = 74.3 bits (181), Expect = 2e-13
Identities = 110/463 (23%), Positives = 196/463 (42%), Gaps = 44/463 (9%)
Query: 45 EEPEDLALQLQQKEKDLLLAA-ELGKMLLERNEELRRQLETLSAQHLEREERLQQENHEL 103
EE E A Q + E+ A EL + L+ NE LR +L+ A+ + +++ L Q E
Sbjct: 1576 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEK 1632
Query: 104 RRGLAARGAEWEARAVELEGDVEALRAQ-LGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
++ A R A +A E L Q L +QR + + ++R A EL +RL
Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRA 1688
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+ Q Q Q L+ EL L+ + A EL L ++ E ++L + + E + R
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748
Query: 223 LREE----VEKGEGRLQTTHEELLLLRRERREHSLELERARSEAG-EALSALRRLQRRVS 277
E+ +E GR + EE LR E + + A +A + A R L +++
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808
Query: 278 ELEEESRLQ-DADVSAASLQSE---LAHSLDDGD------QGQGADAPGDTPTTRSPKTR 327
+ E +RL+ +A+++ ++E L +D + Q A D R + R
Sbjct: 1809 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLAQLR 1867
Query: 328 KASSPQPSPPEEILEPPKKRTSLSPAEILE-------------EKEVEVAKLQDEI---- 370
KAS + + ++E ++ EIL E E+E+ +++
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927
Query: 371 -SLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERD 429
S +QAEL++ R+ +E R + + E + +L+ +EA + ++ R+ + +
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1987
Query: 430 SLSRELLRAIRQKVALTQ-ELEAWQDDMQVVIGQQLRSQRQKE 471
R RA ++ Q EA Q +Q + +QKE
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2030
Score = 67.8 bits (164), Expect = 2e-11
Identities = 105/424 (24%), Positives = 166/424 (39%), Gaps = 41/424 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQL--ETLSAQH-LEREERLQQENHELRRGLAA 109
+L Q++K+L A E + L E E++ +QL ET Q LE E + Q E L
Sbjct: 2298 ELLQQQKEL--AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2355
Query: 110 RGAEWEARAVELEGDVEALRAQ---LGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQ 166
R AE E D + R Q +GE+ + + +E+ + L Q + +
Sbjct: 2356 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2415
Query: 167 ASQTEQELQRELDALRGQCQAQALAGAELRT-RLESLQGENQMLQ----SRRQDLEAQIR 221
+ EL+RE + L+ + + L E++T + E L E Q LQ S + L + R
Sbjct: 2416 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2475
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRE--RREHSLELER---------ARSEAGEALSALR 270
+ +E K E Q + LR E R++ +E ER AR EA +R
Sbjct: 2476 FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535
Query: 271 RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 330
R Q + +LE++ R Q+ A L L ++ A T S +
Sbjct: 2536 RKQEELQQLEQQRRQQEE--LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2593
Query: 331 SPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL 390
P + L+ P + ++V +LQ+ L ELQ L + EL
Sbjct: 2594 LPN---GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2650
Query: 391 RAQEDPGEALHSALSDRD---EAVNKALELSLQLNR---------VSLERDSLSRELLRA 438
+ED L S +A N+ L + L R + LE + S LL
Sbjct: 2651 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2710
Query: 439 IRQK 442
+R +
Sbjct: 2711 VRNR 2714
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/442 (23%), Positives = 179/442 (40%), Gaps = 39/442 (8%)
Query: 48 EDLALQLQQKEKDLLLA-AELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR- 105
E+ Q Q E+D AE ++L E+ + + + +E+ + EN LRR
Sbjct: 1779 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRL 1837
Query: 106 --GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE--------LSE 155
A + E +A + + D+E AQL + DS ER + L E + E
Sbjct: 1838 AEDEAFQRRRLEEQAAQHKADIEERLAQL----RKASDSELERQKGLVEDTLRQRRQVEE 1893
Query: 156 QNLRLSQQLAQASQTEQELQRELDALRGQCQ--AQALAGAELRT-RLESLQGENQMLQSR 212
+ L L +A+ + EL+ EL +R + ++ AEL R L E + R
Sbjct: 1894 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER---R 1950
Query: 213 RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL 272
R++ E +++ E+ + + EE+ L+ + E ERA E+ L +
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSP 332
++ + EE++ LQ L DQ +G R A
Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG---------EAEAARRAAEEA 2061
Query: 333 QPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRA 392
+ + + E + R + AE L++ E A+ + + QA + LR+E +++ RA
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ---AQAAAEKLRKEAEQEAARRA 2118
Query: 393 QEDPGEALHSALSDRD-EAVNKALELSL-QLNRVSLERDSLSRELLRAIRQKVALTQELE 450
Q + +D + E K E +L Q +V E +L +L QK L +EL+
Sbjct: 2119 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2178
Query: 451 AWQDDMQVVIGQQLRSQRQKEL 472
+ + Q RSQ ++EL
Sbjct: 2179 RLKAEATEAARQ--RSQVEEEL 2198
Score = 59.3 bits (142), Expect = 8e-09
Identities = 105/500 (21%), Positives = 188/500 (37%), Gaps = 98/500 (19%)
Query: 56 QKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWE 115
++ K L E K +E LR + E SA+ L+ + Q+ + AE +
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ---------AEEK 2020
Query: 116 ARAVELEGDVEALRAQLGEQRS---EQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
A A ++ + L+ L +++S + + RA E E ++ ++ AQ+ + +
Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2080
Query: 173 ELQRELDALRGQCQAQALAGA---ELRTRLES-----LQGENQMLQSR------------ 212
E +R + Q QA+A A A +LR E Q E L+ +
Sbjct: 2081 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2140
Query: 213 --------RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ +E ++ LR ++E+ + + EEL L+ E E + + + E
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200
Query: 265 ALSALRRLQRRVSELEEESR---LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT 321
+ L + + +E E+R L+D D + LQ E ++
Sbjct: 2201 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2260
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE----- 376
+ + Q + E++L+ +K ++ A L + E E+ + Q E++ +QA
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLK--EKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQED 2317
Query: 377 ----LQSLREELQ---------RQKEL---------------------RAQEDP------ 396
Q L EE Q RQ++L RA+ED
Sbjct: 2318 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2377
Query: 397 ----GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQE---L 449
GE LH E V L +Q + + + L + R+K L QE L
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 450 EAWQDDMQVVIGQQLRSQRQ 469
+ ++MQ V +QL + Q
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQ 2457
Score = 58.5 bits (140), Expect = 1e-08
Identities = 97/473 (20%), Positives = 188/473 (39%), Gaps = 36/473 (7%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E +D+ LQL+ E + ++ L ++E R+ AQ + +++ Q E L +
Sbjct: 956 ELKDIRLQLEACE-----TRTVHRLRLPLDKEPAREC----AQRIAEQQKAQAEVEGLGK 1006
Query: 106 GLAARGAEWEA---------RAVELEGDVEALRAQLGEQRS------EQQDS------GR 144
G+A AE E A L ++E +L + RS E+ + G
Sbjct: 1007 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1066
Query: 145 ERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQG 204
+ A + E+ L+ +Q + + + L LR Q +AQ LR L Q
Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1126
Query: 205 ENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ LQ R + + ++ RE V + R Q + + +RE + +L R E+ +
Sbjct: 1127 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR-ESAD 1185
Query: 265 ALSALRRLQRRVSELEEESRLQDADVSAASLQSE---LAHSLDDGDQGQGADAPGDTPTT 321
L A + RR E + L D+ L+ E L G++ +
Sbjct: 1186 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1245
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEI-SLQQAELQSL 380
+ E + P KK S +E + ++ V++ E+ +L ++ +
Sbjct: 1246 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1305
Query: 381 REELQR-QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAI 439
E L+R ++E R E L++ + A+ K +L+ + + + ++EL + +
Sbjct: 1306 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1365
Query: 440 RQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRL 492
+++V +E + I ++L+ RQ + + + AA R LR+
Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1418
Score = 52.0 bits (123), Expect = 1e-06
Identities = 103/421 (24%), Positives = 166/421 (39%), Gaps = 55/421 (13%)
Query: 75 NEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRA-QLG 133
N+E + + L AQH Q + +++ LA W++ L DV+ +R+ L
Sbjct: 830 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLA-----WQS----LRRDVQLIRSWSLA 880
Query: 134 EQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGA 193
R+ + + R+ +L EL Q Q A E L E + G C
Sbjct: 881 TFRTLKPEEQRQALHSL-ELHYQAFLRDSQDAGGFGPEDRLMAEREY--GSCSHH----- 932
Query: 194 ELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRE-RREHS 252
+ L+SL+ + +SR Q ++++ +R ++E E R T H L L +E RE +
Sbjct: 933 -YQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETR--TVHRLRLPLDKEPARECA 988
Query: 253 LELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGA 312
+ + E + + R +E E+ L + +A +L+SEL +L +Q +
Sbjct: 989 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1048
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEIL---EPPKKRTSLSPAEI--LEEKEVEVAKLQ 367
A KT EE+L E K PA + LE + + KL+
Sbjct: 1049 SAI----YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1104
Query: 368 DEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQL----NR 423
+ QQ +LR+EL R ++ GE L +RD V + E QL
Sbjct: 1105 AQAEAQQPTFDALRDEL------RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1158
Query: 424 VSLERDSLSRELL---RAIRQKVALTQELEAWQDD----------MQVVIGQQLRSQRQK 470
V + D REL R +R L AW D M + Q +R Q ++
Sbjct: 1159 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1218
Query: 471 E 471
E
Sbjct: 1219 E 1219
Score = 32.7 bits (73), Expect = 0.80
Identities = 59/232 (25%), Positives = 98/232 (42%), Gaps = 32/232 (13%)
Query: 66 ELGKM---LLERNEELRRQLETLSAQHLER-EERLQQENHELRRGLAARGAEWEARAVEL 121
E GK+ +LER ++LR + E L L+R +LQ E GL +A A+ L
Sbjct: 337 EWGKLHVAILEREKQLRSEFERLEC--LQRIVTKLQME-----AGLCEEQLN-QADAL-L 387
Query: 122 EGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ-----QLAQASQTEQELQR 176
+ DV L A QR+ + + ++A ++ L +++ + Q Q + L
Sbjct: 388 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 447
Query: 177 ELDALRGQCQAQALAGAEL------RTRLESLQGENQMLQSRR---QDLEAQIRGLREEV 227
L A+R + + AG + L+S+Q ++ S QDL A + + V
Sbjct: 448 RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV 507
Query: 228 EKGEGRLQTTHEELLL-----LRRERREHSLELERARSEAGEALSALRRLQR 274
+ E + E L L + E ++ERARS+ G+ A R R
Sbjct: 508 DGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR 559
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 82.4 bits (202), Expect = 9e-16
Identities = 107/477 (22%), Positives = 189/477 (39%), Gaps = 58/477 (12%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE E LA Q + +E++ L E LE+ +L + H + + + ++E EL+
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAA---LEKQRQL-------AEAHAQAKAQAEREAKELQ 1531
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
+ + E AV+ + +++ +L + R + + +AR LR+ +++
Sbjct: 1532 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591
Query: 165 ----AQASQTEQE---LQRELDALRG---QCQAQALAGAELRTRL-ESLQGENQMLQSRR 213
Q TE++ + EL ALR + +AQ E RL +Q E+Q +
Sbjct: 1592 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1651
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHE-ELLLLRRERREHSLELERARSEAGEALSALRRL 272
+L ++++ E + + LQ E L ERR E+ERAR + AL
Sbjct: 1652 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETA 1707
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDD---------GDQGQGADAPGDTPTTRS 323
QR E+ LQ S A ++L SL + + + A + R
Sbjct: 1708 QR-----SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762
Query: 324 PKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK---EVEVAKLQDEISLQQAELQSL 380
R+ Q E + R L E+ ++K + E K ++E +
Sbjct: 1763 EAERELERWQLKANEAL------RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816
Query: 381 REELQRQKELRAQ--EDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRA 438
E+ RQ+EL Q E + R A + + L + + +R L EL R
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1876
Query: 439 IRQKVALTQ-------ELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRF 488
R+ A TQ EL + +M+V++ + R++ + ++ S A RF
Sbjct: 1877 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1933
Score = 74.3 bits (181), Expect = 2e-13
Identities = 110/463 (23%), Positives = 196/463 (42%), Gaps = 44/463 (9%)
Query: 45 EEPEDLALQLQQKEKDLLLAA-ELGKMLLERNEELRRQLETLSAQHLEREERLQQENHEL 103
EE E A Q + E+ A EL + L+ NE LR +L+ A+ + +++ L Q E
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEK 1801
Query: 104 RRGLAARGAEWEARAVELEGDVEALRAQ-LGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
++ A R A +A E L Q L +QR + + ++R A EL +RL
Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRA 1857
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+ Q Q Q L+ EL L+ + A EL L ++ E ++L + + E + R
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 223 LREE----VEKGEGRLQTTHEELLLLRRERREHSLELERARSEAG-EALSALRRLQRRVS 277
E+ +E GR + EE LR E + + A +A + A R L +++
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977
Query: 278 ELEEESRLQ-DADVSAASLQSE---LAHSLDDGD------QGQGADAPGDTPTTRSPKTR 327
+ E +RL+ +A+++ ++E L +D + Q A D R + R
Sbjct: 1978 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLAQLR 2036
Query: 328 KASSPQPSPPEEILEPPKKRTSLSPAEILE-------------EKEVEVAKLQDEI---- 370
KAS + + ++E ++ EIL E E+E+ +++
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096
Query: 371 -SLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERD 429
S +QAEL++ R+ +E R + + E + +L+ +EA + ++ R+ + +
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2156
Query: 430 SLSRELLRAIRQKVALTQ-ELEAWQDDMQVVIGQQLRSQRQKE 471
R RA ++ Q EA Q +Q + +QKE
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199
Score = 67.8 bits (164), Expect = 2e-11
Identities = 105/424 (24%), Positives = 166/424 (39%), Gaps = 41/424 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQL--ETLSAQH-LEREERLQQENHELRRGLAA 109
+L Q++K+L A E + L E E++ +QL ET Q LE E + Q E L
Sbjct: 2467 ELLQQQKEL--AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2524
Query: 110 RGAEWEARAVELEGDVEALRAQ---LGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQ 166
R AE E D + R Q +GE+ + + +E+ + L Q + +
Sbjct: 2525 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2584
Query: 167 ASQTEQELQRELDALRGQCQAQALAGAELRT-RLESLQGENQMLQ----SRRQDLEAQIR 221
+ EL+RE + L+ + + L E++T + E L E Q LQ S + L + R
Sbjct: 2585 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2644
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRE--RREHSLELER---------ARSEAGEALSALR 270
+ +E K E Q + LR E R++ +E ER AR EA +R
Sbjct: 2645 FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704
Query: 271 RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 330
R Q + +LE++ R Q+ A L L ++ A T S +
Sbjct: 2705 RKQEELQQLEQQRRQQEE--LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2762
Query: 331 SPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL 390
P + L+ P + ++V +LQ+ L ELQ L + EL
Sbjct: 2763 LPN---GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2819
Query: 391 RAQEDPGEALHSALSDRD---EAVNKALELSLQLNR---------VSLERDSLSRELLRA 438
+ED L S +A N+ L + L R + LE + S LL
Sbjct: 2820 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2879
Query: 439 IRQK 442
+R +
Sbjct: 2880 VRNR 2883
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/442 (23%), Positives = 179/442 (40%), Gaps = 39/442 (8%)
Query: 48 EDLALQLQQKEKDLLLA-AELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR- 105
E+ Q Q E+D AE ++L E+ + + + +E+ + EN LRR
Sbjct: 1948 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRL 2006
Query: 106 --GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE--------LSE 155
A + E +A + + D+E AQL + DS ER + L E + E
Sbjct: 2007 AEDEAFQRRRLEEQAAQHKADIEERLAQL----RKASDSELERQKGLVEDTLRQRRQVEE 2062
Query: 156 QNLRLSQQLAQASQTEQELQRELDALRGQCQ--AQALAGAELRT-RLESLQGENQMLQSR 212
+ L L +A+ + EL+ EL +R + ++ AEL R L E + R
Sbjct: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER---R 2119
Query: 213 RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL 272
R++ E +++ E+ + + EE+ L+ + E ERA E+ L +
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSP 332
++ + EE++ LQ L DQ +G R A
Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG---------EAEAARRAAEEA 2230
Query: 333 QPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRA 392
+ + + E + R + AE L++ E A+ + + QA + LR+E +++ RA
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ---AQAAAEKLRKEAEQEAARRA 2287
Query: 393 QEDPGEALHSALSDRD-EAVNKALELSL-QLNRVSLERDSLSRELLRAIRQKVALTQELE 450
Q + +D + E K E +L Q +V E +L +L QK L +EL+
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2347
Query: 451 AWQDDMQVVIGQQLRSQRQKEL 472
+ + Q RSQ ++EL
Sbjct: 2348 RLKAEATEAARQ--RSQVEEEL 2367
Score = 59.3 bits (142), Expect = 8e-09
Identities = 105/500 (21%), Positives = 188/500 (37%), Gaps = 98/500 (19%)
Query: 56 QKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWE 115
++ K L E K +E LR + E SA+ L+ + Q+ + AE +
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ---------AEEK 2189
Query: 116 ARAVELEGDVEALRAQLGEQRS---EQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
A A ++ + L+ L +++S + + RA E E ++ ++ AQ+ + +
Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2249
Query: 173 ELQRELDALRGQCQAQALAGA---ELRTRLES-----LQGENQMLQSR------------ 212
E +R + Q QA+A A A +LR E Q E L+ +
Sbjct: 2250 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2309
Query: 213 --------RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ +E ++ LR ++E+ + + EEL L+ E E + + + E
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369
Query: 265 ALSALRRLQRRVSELEEESR---LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT 321
+ L + + +E E+R L+D D + LQ E ++
Sbjct: 2370 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2429
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE----- 376
+ + Q + E++L+ +K ++ A L + E E+ + Q E++ +QA
Sbjct: 2430 LRQLAEEDLAQQRALAEKMLK--EKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQED 2486
Query: 377 ----LQSLREELQ---------RQKEL---------------------RAQEDP------ 396
Q L EE Q RQ++L RA+ED
Sbjct: 2487 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2546
Query: 397 ----GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQE---L 449
GE LH E V L +Q + + + L + R+K L QE L
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 450 EAWQDDMQVVIGQQLRSQRQ 469
+ ++MQ V +QL + Q
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQ 2626
Score = 58.5 bits (140), Expect = 1e-08
Identities = 97/473 (20%), Positives = 188/473 (39%), Gaps = 36/473 (7%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E +D+ LQL+ E + ++ L ++E R+ AQ + +++ Q E L +
Sbjct: 1125 ELKDIRLQLEACE-----TRTVHRLRLPLDKEPAREC----AQRIAEQQKAQAEVEGLGK 1175
Query: 106 GLAARGAEWEA---------RAVELEGDVEALRAQLGEQRS------EQQDS------GR 144
G+A AE E A L ++E +L + RS E+ + G
Sbjct: 1176 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1235
Query: 145 ERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQG 204
+ A + E+ L+ +Q + + + L LR Q +AQ LR L Q
Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1295
Query: 205 ENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ LQ R + + ++ RE V + R Q + + +RE + +L R E+ +
Sbjct: 1296 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR-ESAD 1354
Query: 265 ALSALRRLQRRVSELEEESRLQDADVSAASLQSE---LAHSLDDGDQGQGADAPGDTPTT 321
L A + RR E + L D+ L+ E L G++ +
Sbjct: 1355 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1414
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEI-SLQQAELQSL 380
+ E + P KK S +E + ++ V++ E+ +L ++ +
Sbjct: 1415 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1474
Query: 381 REELQR-QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAI 439
E L+R ++E R E L++ + A+ K +L+ + + + ++EL + +
Sbjct: 1475 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1534
Query: 440 RQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRL 492
+++V +E + I ++L+ RQ + + + AA R LR+
Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587
Score = 52.0 bits (123), Expect = 1e-06
Identities = 103/421 (24%), Positives = 166/421 (39%), Gaps = 55/421 (13%)
Query: 75 NEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRA-QLG 133
N+E + + L AQH Q + +++ LA W++ L DV+ +R+ L
Sbjct: 999 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLA-----WQS----LRRDVQLIRSWSLA 1049
Query: 134 EQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGA 193
R+ + + R+ +L EL Q Q A E L E + G C
Sbjct: 1050 TFRTLKPEEQRQALHSL-ELHYQAFLRDSQDAGGFGPEDRLMAEREY--GSCSHH----- 1101
Query: 194 ELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRE-RREHS 252
+ L+SL+ + +SR Q ++++ +R ++E E R T H L L +E RE +
Sbjct: 1102 -YQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETR--TVHRLRLPLDKEPARECA 1157
Query: 253 LELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGA 312
+ + E + + R +E E+ L + +A +L+SEL +L +Q +
Sbjct: 1158 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1217
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEIL---EPPKKRTSLSPAEI--LEEKEVEVAKLQ 367
A KT EE+L E K PA + LE + + KL+
Sbjct: 1218 SAI----YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1273
Query: 368 DEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQL----NR 423
+ QQ +LR+EL R ++ GE L +RD V + E QL
Sbjct: 1274 AQAEAQQPTFDALRDEL------RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1327
Query: 424 VSLERDSLSRELL---RAIRQKVALTQELEAWQDD----------MQVVIGQQLRSQRQK 470
V + D REL R +R L AW D M + Q +R Q ++
Sbjct: 1328 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1387
Query: 471 E 471
E
Sbjct: 1388 E 1388
Score = 32.7 bits (73), Expect = 0.80
Identities = 59/232 (25%), Positives = 98/232 (42%), Gaps = 32/232 (13%)
Query: 66 ELGKM---LLERNEELRRQLETLSAQHLER-EERLQQENHELRRGLAARGAEWEARAVEL 121
E GK+ +LER ++LR + E L L+R +LQ E GL +A A+ L
Sbjct: 506 EWGKLHVAILEREKQLRSEFERLEC--LQRIVTKLQME-----AGLCEEQLN-QADAL-L 556
Query: 122 EGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ-----QLAQASQTEQELQR 176
+ DV L A QR+ + + ++A ++ L +++ + Q Q + L
Sbjct: 557 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 616
Query: 177 ELDALRGQCQAQALAGAEL------RTRLESLQGENQMLQSRR---QDLEAQIRGLREEV 227
L A+R + + AG + L+S+Q ++ S QDL A + + V
Sbjct: 617 RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV 676
Query: 228 EKGEGRLQTTHEELLL-----LRRERREHSLELERARSEAGEALSALRRLQR 274
+ E + E L L + E ++ERARS+ G+ A R R
Sbjct: 677 DGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR 728
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 82.4 bits (202), Expect = 9e-16
Identities = 107/477 (22%), Positives = 189/477 (39%), Gaps = 58/477 (12%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE E LA Q + +E++ L E LE+ +L + H + + + ++E EL+
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAA---LEKQRQL-------AEAHAQAKAQAEREAKELQ 1372
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
+ + E AV+ + +++ +L + R + + +AR LR+ +++
Sbjct: 1373 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432
Query: 165 ----AQASQTEQE---LQRELDALRG---QCQAQALAGAELRTRL-ESLQGENQMLQSRR 213
Q TE++ + EL ALR + +AQ E RL +Q E+Q +
Sbjct: 1433 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1492
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHE-ELLLLRRERREHSLELERARSEAGEALSALRRL 272
+L ++++ E + + LQ E L ERR E+ERAR + AL
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETA 1548
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDD---------GDQGQGADAPGDTPTTRS 323
QR E+ LQ S A ++L SL + + + A + R
Sbjct: 1549 QR-----SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603
Query: 324 PKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK---EVEVAKLQDEISLQQAELQSL 380
R+ Q E + R L E+ ++K + E K ++E +
Sbjct: 1604 EAERELERWQLKANEAL------RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1657
Query: 381 REELQRQKELRAQ--EDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRA 438
E+ RQ+EL Q E + R A + + L + + +R L EL R
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717
Query: 439 IRQKVALTQ-------ELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRF 488
R+ A TQ EL + +M+V++ + R++ + ++ S A RF
Sbjct: 1718 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1774
Score = 74.3 bits (181), Expect = 2e-13
Identities = 110/463 (23%), Positives = 196/463 (42%), Gaps = 44/463 (9%)
Query: 45 EEPEDLALQLQQKEKDLLLAA-ELGKMLLERNEELRRQLETLSAQHLEREERLQQENHEL 103
EE E A Q + E+ A EL + L+ NE LR +L+ A+ + +++ L Q E
Sbjct: 1586 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEK 1642
Query: 104 RRGLAARGAEWEARAVELEGDVEALRAQ-LGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
++ A R A +A E L Q L +QR + + ++R A EL +RL
Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRA 1698
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+ Q Q Q L+ EL L+ + A EL L ++ E ++L + + E + R
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758
Query: 223 LREE----VEKGEGRLQTTHEELLLLRRERREHSLELERARSEAG-EALSALRRLQRRVS 277
E+ +E GR + EE LR E + + A +A + A R L +++
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
Query: 278 ELEEESRLQ-DADVSAASLQSE---LAHSLDDGD------QGQGADAPGDTPTTRSPKTR 327
+ E +RL+ +A+++ ++E L +D + Q A D R + R
Sbjct: 1819 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLAQLR 1877
Query: 328 KASSPQPSPPEEILEPPKKRTSLSPAEILE-------------EKEVEVAKLQDEI---- 370
KAS + + ++E ++ EIL E E+E+ +++
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937
Query: 371 -SLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERD 429
S +QAEL++ R+ +E R + + E + +L+ +EA + ++ R+ + +
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1997
Query: 430 SLSRELLRAIRQKVALTQ-ELEAWQDDMQVVIGQQLRSQRQKE 471
R RA ++ Q EA Q +Q + +QKE
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
Score = 67.8 bits (164), Expect = 2e-11
Identities = 105/424 (24%), Positives = 166/424 (39%), Gaps = 41/424 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQL--ETLSAQH-LEREERLQQENHELRRGLAA 109
+L Q++K+L A E + L E E++ +QL ET Q LE E + Q E L
Sbjct: 2308 ELLQQQKEL--AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2365
Query: 110 RGAEWEARAVELEGDVEALRAQ---LGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQ 166
R AE E D + R Q +GE+ + + +E+ + L Q + +
Sbjct: 2366 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2425
Query: 167 ASQTEQELQRELDALRGQCQAQALAGAELRT-RLESLQGENQMLQ----SRRQDLEAQIR 221
+ EL+RE + L+ + + L E++T + E L E Q LQ S + L + R
Sbjct: 2426 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2485
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRE--RREHSLELER---------ARSEAGEALSALR 270
+ +E K E Q + LR E R++ +E ER AR EA +R
Sbjct: 2486 FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2545
Query: 271 RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 330
R Q + +LE++ R Q+ A L L ++ A T S +
Sbjct: 2546 RKQEELQQLEQQRRQQEE--LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2603
Query: 331 SPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL 390
P + L+ P + ++V +LQ+ L ELQ L + EL
Sbjct: 2604 LPN---GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2660
Query: 391 RAQEDPGEALHSALSDRD---EAVNKALELSLQLNR---------VSLERDSLSRELLRA 438
+ED L S +A N+ L + L R + LE + S LL
Sbjct: 2661 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2720
Query: 439 IRQK 442
+R +
Sbjct: 2721 VRNR 2724
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/442 (23%), Positives = 179/442 (40%), Gaps = 39/442 (8%)
Query: 48 EDLALQLQQKEKDLLLA-AELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR- 105
E+ Q Q E+D AE ++L E+ + + + +E+ + EN LRR
Sbjct: 1789 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRL 1847
Query: 106 --GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE--------LSE 155
A + E +A + + D+E AQL + DS ER + L E + E
Sbjct: 1848 AEDEAFQRRRLEEQAAQHKADIEERLAQL----RKASDSELERQKGLVEDTLRQRRQVEE 1903
Query: 156 QNLRLSQQLAQASQTEQELQRELDALRGQCQ--AQALAGAELRT-RLESLQGENQMLQSR 212
+ L L +A+ + EL+ EL +R + ++ AEL R L E + R
Sbjct: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER---R 1960
Query: 213 RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL 272
R++ E +++ E+ + + EE+ L+ + E ERA E+ L +
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSP 332
++ + EE++ LQ L DQ +G R A
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG---------EAEAARRAAEEA 2071
Query: 333 QPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRA 392
+ + + E + R + AE L++ E A+ + + QA + LR+E +++ RA
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ---AQAAAEKLRKEAEQEAARRA 2128
Query: 393 QEDPGEALHSALSDRD-EAVNKALELSL-QLNRVSLERDSLSRELLRAIRQKVALTQELE 450
Q + +D + E K E +L Q +V E +L +L QK L +EL+
Sbjct: 2129 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2188
Query: 451 AWQDDMQVVIGQQLRSQRQKEL 472
+ + Q RSQ ++EL
Sbjct: 2189 RLKAEATEAARQ--RSQVEEEL 2208
Score = 59.3 bits (142), Expect = 8e-09
Identities = 105/500 (21%), Positives = 188/500 (37%), Gaps = 98/500 (19%)
Query: 56 QKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWE 115
++ K L E K +E LR + E SA+ L+ + Q+ + AE +
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ---------AEEK 2030
Query: 116 ARAVELEGDVEALRAQLGEQRS---EQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
A A ++ + L+ L +++S + + RA E E ++ ++ AQ+ + +
Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2090
Query: 173 ELQRELDALRGQCQAQALAGA---ELRTRLES-----LQGENQMLQSR------------ 212
E +R + Q QA+A A A +LR E Q E L+ +
Sbjct: 2091 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2150
Query: 213 --------RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ +E ++ LR ++E+ + + EEL L+ E E + + + E
Sbjct: 2151 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2210
Query: 265 ALSALRRLQRRVSELEEESR---LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT 321
+ L + + +E E+R L+D D + LQ E ++
Sbjct: 2211 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2270
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE----- 376
+ + Q + E++L+ +K ++ A L + E E+ + Q E++ +QA
Sbjct: 2271 LRQLAEEDLAQQRALAEKMLK--EKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQED 2327
Query: 377 ----LQSLREELQ---------RQKEL---------------------RAQEDP------ 396
Q L EE Q RQ++L RA+ED
Sbjct: 2328 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2387
Query: 397 ----GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQE---L 449
GE LH E V L +Q + + + L + R+K L QE L
Sbjct: 2388 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
Query: 450 EAWQDDMQVVIGQQLRSQRQ 469
+ ++MQ V +QL + Q
Sbjct: 2448 QLKSEEMQTVQQEQLLQETQ 2467
Score = 58.5 bits (140), Expect = 1e-08
Identities = 97/473 (20%), Positives = 188/473 (39%), Gaps = 36/473 (7%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E +D+ LQL+ E + ++ L ++E R+ AQ + +++ Q E L +
Sbjct: 966 ELKDIRLQLEACE-----TRTVHRLRLPLDKEPAREC----AQRIAEQQKAQAEVEGLGK 1016
Query: 106 GLAARGAEWEA---------RAVELEGDVEALRAQLGEQRS------EQQDS------GR 144
G+A AE E A L ++E +L + RS E+ + G
Sbjct: 1017 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1076
Query: 145 ERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQG 204
+ A + E+ L+ +Q + + + L LR Q +AQ LR L Q
Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1136
Query: 205 ENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ LQ R + + ++ RE V + R Q + + +RE + +L R E+ +
Sbjct: 1137 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR-ESAD 1195
Query: 265 ALSALRRLQRRVSELEEESRLQDADVSAASLQSE---LAHSLDDGDQGQGADAPGDTPTT 321
L A + RR E + L D+ L+ E L G++ +
Sbjct: 1196 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1255
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEI-SLQQAELQSL 380
+ E + P KK S +E + ++ V++ E+ +L ++ +
Sbjct: 1256 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1315
Query: 381 REELQR-QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAI 439
E L+R ++E R E L++ + A+ K +L+ + + + ++EL + +
Sbjct: 1316 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1375
Query: 440 RQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRL 492
+++V +E + I ++L+ RQ + + + AA R LR+
Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
Score = 52.0 bits (123), Expect = 1e-06
Identities = 103/421 (24%), Positives = 166/421 (39%), Gaps = 55/421 (13%)
Query: 75 NEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRA-QLG 133
N+E + + L AQH Q + +++ LA W++ L DV+ +R+ L
Sbjct: 840 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLA-----WQS----LRRDVQLIRSWSLA 890
Query: 134 EQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGA 193
R+ + + R+ +L EL Q Q A E L E + G C
Sbjct: 891 TFRTLKPEEQRQALHSL-ELHYQAFLRDSQDAGGFGPEDRLMAEREY--GSCSHH----- 942
Query: 194 ELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRE-RREHS 252
+ L+SL+ + +SR Q ++++ +R ++E E R T H L L +E RE +
Sbjct: 943 -YQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETR--TVHRLRLPLDKEPARECA 998
Query: 253 LELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGA 312
+ + E + + R +E E+ L + +A +L+SEL +L +Q +
Sbjct: 999 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1058
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEIL---EPPKKRTSLSPAEI--LEEKEVEVAKLQ 367
A KT EE+L E K PA + LE + + KL+
Sbjct: 1059 SAI----YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1114
Query: 368 DEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQL----NR 423
+ QQ +LR+EL R ++ GE L +RD V + E QL
Sbjct: 1115 AQAEAQQPTFDALRDEL------RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1168
Query: 424 VSLERDSLSRELL---RAIRQKVALTQELEAWQDD----------MQVVIGQQLRSQRQK 470
V + D REL R +R L AW D M + Q +R Q ++
Sbjct: 1169 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1228
Query: 471 E 471
E
Sbjct: 1229 E 1229
Score = 32.7 bits (73), Expect = 0.80
Identities = 59/232 (25%), Positives = 98/232 (42%), Gaps = 32/232 (13%)
Query: 66 ELGKM---LLERNEELRRQLETLSAQHLER-EERLQQENHELRRGLAARGAEWEARAVEL 121
E GK+ +LER ++LR + E L L+R +LQ E GL +A A+ L
Sbjct: 347 EWGKLHVAILEREKQLRSEFERLEC--LQRIVTKLQME-----AGLCEEQLN-QADAL-L 397
Query: 122 EGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ-----QLAQASQTEQELQR 176
+ DV L A QR+ + + ++A ++ L +++ + Q Q + L
Sbjct: 398 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 457
Query: 177 ELDALRGQCQAQALAGAEL------RTRLESLQGENQMLQSRR---QDLEAQIRGLREEV 227
L A+R + + AG + L+S+Q ++ S QDL A + + V
Sbjct: 458 RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV 517
Query: 228 EKGEGRLQTTHEELLL-----LRRERREHSLELERARSEAGEALSALRRLQR 274
+ E + E L L + E ++ERARS+ G+ A R R
Sbjct: 518 DGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR 569
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 82.4 bits (202), Expect = 9e-16
Identities = 107/477 (22%), Positives = 189/477 (39%), Gaps = 58/477 (12%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE E LA Q + +E++ L E LE+ +L + H + + + ++E EL+
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAA---LEKQRQL-------AEAHAQAKAQAEREAKELQ 1380
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
+ + E AV+ + +++ +L + R + + +AR LR+ +++
Sbjct: 1381 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440
Query: 165 ----AQASQTEQE---LQRELDALRG---QCQAQALAGAELRTRL-ESLQGENQMLQSRR 213
Q TE++ + EL ALR + +AQ E RL +Q E+Q +
Sbjct: 1441 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1500
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHE-ELLLLRRERREHSLELERARSEAGEALSALRRL 272
+L ++++ E + + LQ E L ERR E+ERAR + AL
Sbjct: 1501 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETA 1556
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDD---------GDQGQGADAPGDTPTTRS 323
QR E+ LQ S A ++L SL + + + A + R
Sbjct: 1557 QR-----SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611
Query: 324 PKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK---EVEVAKLQDEISLQQAELQSL 380
R+ Q E + R L E+ ++K + E K ++E +
Sbjct: 1612 EAERELERWQLKANEAL------RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1665
Query: 381 REELQRQKELRAQ--EDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRA 438
E+ RQ+EL Q E + R A + + L + + +R L EL R
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1725
Query: 439 IRQKVALTQ-------ELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRF 488
R+ A TQ EL + +M+V++ + R++ + ++ S A RF
Sbjct: 1726 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1782
Score = 74.3 bits (181), Expect = 2e-13
Identities = 110/463 (23%), Positives = 196/463 (42%), Gaps = 44/463 (9%)
Query: 45 EEPEDLALQLQQKEKDLLLAA-ELGKMLLERNEELRRQLETLSAQHLEREERLQQENHEL 103
EE E A Q + E+ A EL + L+ NE LR +L+ A+ + +++ L Q E
Sbjct: 1594 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEK 1650
Query: 104 RRGLAARGAEWEARAVELEGDVEALRAQ-LGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
++ A R A +A E L Q L +QR + + ++R A EL +RL
Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRA 1706
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+ Q Q Q L+ EL L+ + A EL L ++ E ++L + + E + R
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766
Query: 223 LREE----VEKGEGRLQTTHEELLLLRRERREHSLELERARSEAG-EALSALRRLQRRVS 277
E+ +E GR + EE LR E + + A +A + A R L +++
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826
Query: 278 ELEEESRLQ-DADVSAASLQSE---LAHSLDDGD------QGQGADAPGDTPTTRSPKTR 327
+ E +RL+ +A+++ ++E L +D + Q A D R + R
Sbjct: 1827 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLAQLR 1885
Query: 328 KASSPQPSPPEEILEPPKKRTSLSPAEILE-------------EKEVEVAKLQDEI---- 370
KAS + + ++E ++ EIL E E+E+ +++
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1945
Query: 371 -SLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERD 429
S +QAEL++ R+ +E R + + E + +L+ +EA + ++ R+ + +
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2005
Query: 430 SLSRELLRAIRQKVALTQ-ELEAWQDDMQVVIGQQLRSQRQKE 471
R RA ++ Q EA Q +Q + +QKE
Sbjct: 2006 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2048
Score = 67.8 bits (164), Expect = 2e-11
Identities = 105/424 (24%), Positives = 166/424 (39%), Gaps = 41/424 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQL--ETLSAQH-LEREERLQQENHELRRGLAA 109
+L Q++K+L A E + L E E++ +QL ET Q LE E + Q E L
Sbjct: 2316 ELLQQQKEL--AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2373
Query: 110 RGAEWEARAVELEGDVEALRAQ---LGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQ 166
R AE E D + R Q +GE+ + + +E+ + L Q + +
Sbjct: 2374 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2433
Query: 167 ASQTEQELQRELDALRGQCQAQALAGAELRT-RLESLQGENQMLQ----SRRQDLEAQIR 221
+ EL+RE + L+ + + L E++T + E L E Q LQ S + L + R
Sbjct: 2434 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2493
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRE--RREHSLELER---------ARSEAGEALSALR 270
+ +E K E Q + LR E R++ +E ER AR EA +R
Sbjct: 2494 FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2553
Query: 271 RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 330
R Q + +LE++ R Q+ A L L ++ A T S +
Sbjct: 2554 RKQEELQQLEQQRRQQEE--LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2611
Query: 331 SPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL 390
P + L+ P + ++V +LQ+ L ELQ L + EL
Sbjct: 2612 LPN---GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2668
Query: 391 RAQEDPGEALHSALSDRD---EAVNKALELSLQLNR---------VSLERDSLSRELLRA 438
+ED L S +A N+ L + L R + LE + S LL
Sbjct: 2669 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2728
Query: 439 IRQK 442
+R +
Sbjct: 2729 VRNR 2732
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/442 (23%), Positives = 179/442 (40%), Gaps = 39/442 (8%)
Query: 48 EDLALQLQQKEKDLLLA-AELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR- 105
E+ Q Q E+D AE ++L E+ + + + +E+ + EN LRR
Sbjct: 1797 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRL 1855
Query: 106 --GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE--------LSE 155
A + E +A + + D+E AQL + DS ER + L E + E
Sbjct: 1856 AEDEAFQRRRLEEQAAQHKADIEERLAQL----RKASDSELERQKGLVEDTLRQRRQVEE 1911
Query: 156 QNLRLSQQLAQASQTEQELQRELDALRGQCQ--AQALAGAELRT-RLESLQGENQMLQSR 212
+ L L +A+ + EL+ EL +R + ++ AEL R L E + R
Sbjct: 1912 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER---R 1968
Query: 213 RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL 272
R++ E +++ E+ + + EE+ L+ + E ERA E+ L +
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSP 332
++ + EE++ LQ L DQ +G R A
Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG---------EAEAARRAAEEA 2079
Query: 333 QPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRA 392
+ + + E + R + AE L++ E A+ + + QA + LR+E +++ RA
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ---AQAAAEKLRKEAEQEAARRA 2136
Query: 393 QEDPGEALHSALSDRD-EAVNKALELSL-QLNRVSLERDSLSRELLRAIRQKVALTQELE 450
Q + +D + E K E +L Q +V E +L +L QK L +EL+
Sbjct: 2137 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2196
Query: 451 AWQDDMQVVIGQQLRSQRQKEL 472
+ + Q RSQ ++EL
Sbjct: 2197 RLKAEATEAARQ--RSQVEEEL 2216
Score = 59.3 bits (142), Expect = 8e-09
Identities = 105/500 (21%), Positives = 188/500 (37%), Gaps = 98/500 (19%)
Query: 56 QKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWE 115
++ K L E K +E LR + E SA+ L+ + Q+ + AE +
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ---------AEEK 2038
Query: 116 ARAVELEGDVEALRAQLGEQRS---EQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
A A ++ + L+ L +++S + + RA E E ++ ++ AQ+ + +
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2098
Query: 173 ELQRELDALRGQCQAQALAGA---ELRTRLES-----LQGENQMLQSR------------ 212
E +R + Q QA+A A A +LR E Q E L+ +
Sbjct: 2099 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2158
Query: 213 --------RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ +E ++ LR ++E+ + + EEL L+ E E + + + E
Sbjct: 2159 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2218
Query: 265 ALSALRRLQRRVSELEEESR---LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT 321
+ L + + +E E+R L+D D + LQ E ++
Sbjct: 2219 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2278
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE----- 376
+ + Q + E++L+ +K ++ A L + E E+ + Q E++ +QA
Sbjct: 2279 LRQLAEEDLAQQRALAEKMLK--EKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQED 2335
Query: 377 ----LQSLREELQ---------RQKEL---------------------RAQEDP------ 396
Q L EE Q RQ++L RA+ED
Sbjct: 2336 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2395
Query: 397 ----GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQE---L 449
GE LH E V L +Q + + + L + R+K L QE L
Sbjct: 2396 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2455
Query: 450 EAWQDDMQVVIGQQLRSQRQ 469
+ ++MQ V +QL + Q
Sbjct: 2456 QLKSEEMQTVQQEQLLQETQ 2475
Score = 58.5 bits (140), Expect = 1e-08
Identities = 97/473 (20%), Positives = 188/473 (39%), Gaps = 36/473 (7%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E +D+ LQL+ E + ++ L ++E R+ AQ + +++ Q E L +
Sbjct: 974 ELKDIRLQLEACE-----TRTVHRLRLPLDKEPAREC----AQRIAEQQKAQAEVEGLGK 1024
Query: 106 GLAARGAEWEA---------RAVELEGDVEALRAQLGEQRS------EQQDS------GR 144
G+A AE E A L ++E +L + RS E+ + G
Sbjct: 1025 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1084
Query: 145 ERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQG 204
+ A + E+ L+ +Q + + + L LR Q +AQ LR L Q
Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1144
Query: 205 ENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ LQ R + + ++ RE V + R Q + + +RE + +L R E+ +
Sbjct: 1145 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR-ESAD 1203
Query: 265 ALSALRRLQRRVSELEEESRLQDADVSAASLQSE---LAHSLDDGDQGQGADAPGDTPTT 321
L A + RR E + L D+ L+ E L G++ +
Sbjct: 1204 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1263
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEI-SLQQAELQSL 380
+ E + P KK S +E + ++ V++ E+ +L ++ +
Sbjct: 1264 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1323
Query: 381 REELQR-QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAI 439
E L+R ++E R E L++ + A+ K +L+ + + + ++EL + +
Sbjct: 1324 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1383
Query: 440 RQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRL 492
+++V +E + I ++L+ RQ + + + AA R LR+
Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1436
Score = 52.0 bits (123), Expect = 1e-06
Identities = 103/421 (24%), Positives = 166/421 (39%), Gaps = 55/421 (13%)
Query: 75 NEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRA-QLG 133
N+E + + L AQH Q + +++ LA W++ L DV+ +R+ L
Sbjct: 848 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLA-----WQS----LRRDVQLIRSWSLA 898
Query: 134 EQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGA 193
R+ + + R+ +L EL Q Q A E L E + G C
Sbjct: 899 TFRTLKPEEQRQALHSL-ELHYQAFLRDSQDAGGFGPEDRLMAEREY--GSCSHH----- 950
Query: 194 ELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRE-RREHS 252
+ L+SL+ + +SR Q ++++ +R ++E E R T H L L +E RE +
Sbjct: 951 -YQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETR--TVHRLRLPLDKEPARECA 1006
Query: 253 LELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGA 312
+ + E + + R +E E+ L + +A +L+SEL +L +Q +
Sbjct: 1007 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1066
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEIL---EPPKKRTSLSPAEI--LEEKEVEVAKLQ 367
A KT EE+L E K PA + LE + + KL+
Sbjct: 1067 SAI----YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1122
Query: 368 DEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQL----NR 423
+ QQ +LR+EL R ++ GE L +RD V + E QL
Sbjct: 1123 AQAEAQQPTFDALRDEL------RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1176
Query: 424 VSLERDSLSRELL---RAIRQKVALTQELEAWQDD----------MQVVIGQQLRSQRQK 470
V + D REL R +R L AW D M + Q +R Q ++
Sbjct: 1177 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1236
Query: 471 E 471
E
Sbjct: 1237 E 1237
Score = 32.7 bits (73), Expect = 0.80
Identities = 59/232 (25%), Positives = 98/232 (42%), Gaps = 32/232 (13%)
Query: 66 ELGKM---LLERNEELRRQLETLSAQHLER-EERLQQENHELRRGLAARGAEWEARAVEL 121
E GK+ +LER ++LR + E L L+R +LQ E GL +A A+ L
Sbjct: 355 EWGKLHVAILEREKQLRSEFERLEC--LQRIVTKLQME-----AGLCEEQLN-QADAL-L 405
Query: 122 EGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ-----QLAQASQTEQELQR 176
+ DV L A QR+ + + ++A ++ L +++ + Q Q + L
Sbjct: 406 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 465
Query: 177 ELDALRGQCQAQALAGAEL------RTRLESLQGENQMLQSRR---QDLEAQIRGLREEV 227
L A+R + + AG + L+S+Q ++ S QDL A + + V
Sbjct: 466 RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV 525
Query: 228 EKGEGRLQTTHEELLL-----LRRERREHSLELERARSEAGEALSALRRLQR 274
+ E + E L L + E ++ERARS+ G+ A R R
Sbjct: 526 DGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR 577
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 82.4 bits (202), Expect = 9e-16
Identities = 107/477 (22%), Positives = 189/477 (39%), Gaps = 58/477 (12%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE E LA Q + +E++ L E LE+ +L + H + + + ++E EL+
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAA---LEKQRQL-------AEAHAQAKAQAEREAKELQ 1421
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
+ + E AV+ + +++ +L + R + + +AR LR+ +++
Sbjct: 1422 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481
Query: 165 ----AQASQTEQE---LQRELDALRG---QCQAQALAGAELRTRL-ESLQGENQMLQSRR 213
Q TE++ + EL ALR + +AQ E RL +Q E+Q +
Sbjct: 1482 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1541
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHE-ELLLLRRERREHSLELERARSEAGEALSALRRL 272
+L ++++ E + + LQ E L ERR E+ERAR + AL
Sbjct: 1542 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETA 1597
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDD---------GDQGQGADAPGDTPTTRS 323
QR E+ LQ S A ++L SL + + + A + R
Sbjct: 1598 QR-----SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652
Query: 324 PKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK---EVEVAKLQDEISLQQAELQSL 380
R+ Q E + R L E+ ++K + E K ++E +
Sbjct: 1653 EAERELERWQLKANEAL------RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1706
Query: 381 REELQRQKELRAQ--EDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRA 438
E+ RQ+EL Q E + R A + + L + + +R L EL R
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1766
Query: 439 IRQKVALTQ-------ELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRF 488
R+ A TQ EL + +M+V++ + R++ + ++ S A RF
Sbjct: 1767 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1823
Score = 74.3 bits (181), Expect = 2e-13
Identities = 110/463 (23%), Positives = 196/463 (42%), Gaps = 44/463 (9%)
Query: 45 EEPEDLALQLQQKEKDLLLAA-ELGKMLLERNEELRRQLETLSAQHLEREERLQQENHEL 103
EE E A Q + E+ A EL + L+ NE LR +L+ A+ + +++ L Q E
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEK 1691
Query: 104 RRGLAARGAEWEARAVELEGDVEALRAQ-LGEQRSEQQDSGRERARALSELSEQNLRLSQ 162
++ A R A +A E L Q L +QR + + ++R A EL +RL
Sbjct: 1692 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRA 1747
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRG 222
+ Q Q Q L+ EL L+ + A EL L ++ E ++L + + E + R
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807
Query: 223 LREE----VEKGEGRLQTTHEELLLLRRERREHSLELERARSEAG-EALSALRRLQRRVS 277
E+ +E GR + EE LR E + + A +A + A R L +++
Sbjct: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
Query: 278 ELEEESRLQ-DADVSAASLQSE---LAHSLDDGD------QGQGADAPGDTPTTRSPKTR 327
+ E +RL+ +A+++ ++E L +D + Q A D R + R
Sbjct: 1868 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLAQLR 1926
Query: 328 KASSPQPSPPEEILEPPKKRTSLSPAEILE-------------EKEVEVAKLQDEI---- 370
KAS + + ++E ++ EIL E E+E+ +++
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1986
Query: 371 -SLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERD 429
S +QAEL++ R+ +E R + + E + +L+ +EA + ++ R+ + +
Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2046
Query: 430 SLSRELLRAIRQKVALTQ-ELEAWQDDMQVVIGQQLRSQRQKE 471
R RA ++ Q EA Q +Q + +QKE
Sbjct: 2047 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089
Score = 67.8 bits (164), Expect = 2e-11
Identities = 105/424 (24%), Positives = 166/424 (39%), Gaps = 41/424 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQL--ETLSAQH-LEREERLQQENHELRRGLAA 109
+L Q++K+L A E + L E E++ +QL ET Q LE E + Q E L
Sbjct: 2357 ELLQQQKEL--AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2414
Query: 110 RGAEWEARAVELEGDVEALRAQ---LGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQ 166
R AE E D + R Q +GE+ + + +E+ + L Q + +
Sbjct: 2415 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2474
Query: 167 ASQTEQELQRELDALRGQCQAQALAGAELRT-RLESLQGENQMLQ----SRRQDLEAQIR 221
+ EL+RE + L+ + + L E++T + E L E Q LQ S + L + R
Sbjct: 2475 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2534
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRE--RREHSLELER---------ARSEAGEALSALR 270
+ +E K E Q + LR E R++ +E ER AR EA +R
Sbjct: 2535 FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594
Query: 271 RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 330
R Q + +LE++ R Q+ A L L ++ A T S +
Sbjct: 2595 RKQEELQQLEQQRRQQEE--LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
Query: 331 SPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL 390
P + L+ P + ++V +LQ+ L ELQ L + EL
Sbjct: 2653 LPN---GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2709
Query: 391 RAQEDPGEALHSALSDRD---EAVNKALELSLQLNR---------VSLERDSLSRELLRA 438
+ED L S +A N+ L + L R + LE + S LL
Sbjct: 2710 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2769
Query: 439 IRQK 442
+R +
Sbjct: 2770 VRNR 2773
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/442 (23%), Positives = 179/442 (40%), Gaps = 39/442 (8%)
Query: 48 EDLALQLQQKEKDLLLA-AELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR- 105
E+ Q Q E+D AE ++L E+ + + + +E+ + EN LRR
Sbjct: 1838 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRL 1896
Query: 106 --GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE--------LSE 155
A + E +A + + D+E AQL + DS ER + L E + E
Sbjct: 1897 AEDEAFQRRRLEEQAAQHKADIEERLAQL----RKASDSELERQKGLVEDTLRQRRQVEE 1952
Query: 156 QNLRLSQQLAQASQTEQELQRELDALRGQCQ--AQALAGAELRT-RLESLQGENQMLQSR 212
+ L L +A+ + EL+ EL +R + ++ AEL R L E + R
Sbjct: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER---R 2009
Query: 213 RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRL 272
R++ E +++ E+ + + EE+ L+ + E ERA E+ L +
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
Query: 273 QRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSP 332
++ + EE++ LQ L DQ +G R A
Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG---------EAEAARRAAEEA 2120
Query: 333 QPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRA 392
+ + + E + R + AE L++ E A+ + + QA + LR+E +++ RA
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ---AQAAAEKLRKEAEQEAARRA 2177
Query: 393 QEDPGEALHSALSDRD-EAVNKALELSL-QLNRVSLERDSLSRELLRAIRQKVALTQELE 450
Q + +D + E K E +L Q +V E +L +L QK L +EL+
Sbjct: 2178 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2237
Query: 451 AWQDDMQVVIGQQLRSQRQKEL 472
+ + Q RSQ ++EL
Sbjct: 2238 RLKAEATEAARQ--RSQVEEEL 2257
Score = 59.3 bits (142), Expect = 8e-09
Identities = 105/500 (21%), Positives = 188/500 (37%), Gaps = 98/500 (19%)
Query: 56 QKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWE 115
++ K L E K +E LR + E SA+ L+ + Q+ + AE +
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ---------AEEK 2079
Query: 116 ARAVELEGDVEALRAQLGEQRS---EQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
A A ++ + L+ L +++S + + RA E E ++ ++ AQ+ + +
Sbjct: 2080 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2139
Query: 173 ELQRELDALRGQCQAQALAGA---ELRTRLES-----LQGENQMLQSR------------ 212
E +R + Q QA+A A A +LR E Q E L+ +
Sbjct: 2140 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2199
Query: 213 --------RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ +E ++ LR ++E+ + + EEL L+ E E + + + E
Sbjct: 2200 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2259
Query: 265 ALSALRRLQRRVSELEEESR---LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT 321
+ L + + +E E+R L+D D + LQ E ++
Sbjct: 2260 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2319
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE----- 376
+ + Q + E++L+ +K ++ A L + E E+ + Q E++ +QA
Sbjct: 2320 LRQLAEEDLAQQRALAEKMLK--EKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQED 2376
Query: 377 ----LQSLREELQ---------RQKEL---------------------RAQEDP------ 396
Q L EE Q RQ++L RA+ED
Sbjct: 2377 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2436
Query: 397 ----GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQE---L 449
GE LH E V L +Q + + + L + R+K L QE L
Sbjct: 2437 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
Query: 450 EAWQDDMQVVIGQQLRSQRQ 469
+ ++MQ V +QL + Q
Sbjct: 2497 QLKSEEMQTVQQEQLLQETQ 2516
Score = 58.5 bits (140), Expect = 1e-08
Identities = 97/473 (20%), Positives = 188/473 (39%), Gaps = 36/473 (7%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E +D+ LQL+ E + ++ L ++E R+ AQ + +++ Q E L +
Sbjct: 1015 ELKDIRLQLEACE-----TRTVHRLRLPLDKEPAREC----AQRIAEQQKAQAEVEGLGK 1065
Query: 106 GLAARGAEWEA---------RAVELEGDVEALRAQLGEQRS------EQQDS------GR 144
G+A AE E A L ++E +L + RS E+ + G
Sbjct: 1066 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1125
Query: 145 ERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQG 204
+ A + E+ L+ +Q + + + L LR Q +AQ LR L Q
Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1185
Query: 205 ENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE 264
+ LQ R + + ++ RE V + R Q + + +RE + +L R E+ +
Sbjct: 1186 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR-ESAD 1244
Query: 265 ALSALRRLQRRVSELEEESRLQDADVSAASLQSE---LAHSLDDGDQGQGADAPGDTPTT 321
L A + RR E + L D+ L+ E L G++ +
Sbjct: 1245 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1304
Query: 322 RSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEI-SLQQAELQSL 380
+ E + P KK S +E + ++ V++ E+ +L ++ +
Sbjct: 1305 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1364
Query: 381 REELQR-QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAI 439
E L+R ++E R E L++ + A+ K +L+ + + + ++EL + +
Sbjct: 1365 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424
Query: 440 RQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRL 492
+++V +E + I ++L+ RQ + + + AA R LR+
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
Score = 52.0 bits (123), Expect = 1e-06
Identities = 103/421 (24%), Positives = 166/421 (39%), Gaps = 55/421 (13%)
Query: 75 NEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRA-QLG 133
N+E + + L AQH Q + +++ LA W++ L DV+ +R+ L
Sbjct: 889 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLA-----WQS----LRRDVQLIRSWSLA 939
Query: 134 EQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGA 193
R+ + + R+ +L EL Q Q A E L E + G C
Sbjct: 940 TFRTLKPEEQRQALHSL-ELHYQAFLRDSQDAGGFGPEDRLMAEREY--GSCSHH----- 991
Query: 194 ELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRE-RREHS 252
+ L+SL+ + +SR Q ++++ +R ++E E R T H L L +E RE +
Sbjct: 992 -YQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETR--TVHRLRLPLDKEPARECA 1047
Query: 253 LELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGA 312
+ + E + + R +E E+ L + +A +L+SEL +L +Q +
Sbjct: 1048 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1107
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEIL---EPPKKRTSLSPAEI--LEEKEVEVAKLQ 367
A KT EE+L E K PA + LE + + KL+
Sbjct: 1108 SAI----YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1163
Query: 368 DEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQL----NR 423
+ QQ +LR+EL R ++ GE L +RD V + E QL
Sbjct: 1164 AQAEAQQPTFDALRDEL------RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1217
Query: 424 VSLERDSLSRELL---RAIRQKVALTQELEAWQDD----------MQVVIGQQLRSQRQK 470
V + D REL R +R L AW D M + Q +R Q ++
Sbjct: 1218 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1277
Query: 471 E 471
E
Sbjct: 1278 E 1278
Score = 32.7 bits (73), Expect = 0.80
Identities = 59/232 (25%), Positives = 98/232 (42%), Gaps = 32/232 (13%)
Query: 66 ELGKM---LLERNEELRRQLETLSAQHLER-EERLQQENHELRRGLAARGAEWEARAVEL 121
E GK+ +LER ++LR + E L L+R +LQ E GL +A A+ L
Sbjct: 396 EWGKLHVAILEREKQLRSEFERLEC--LQRIVTKLQME-----AGLCEEQLN-QADAL-L 446
Query: 122 EGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQ-----QLAQASQTEQELQR 176
+ DV L A QR+ + + ++A ++ L +++ + Q Q + L
Sbjct: 447 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 506
Query: 177 ELDALRGQCQAQALAGAEL------RTRLESLQGENQMLQSRR---QDLEAQIRGLREEV 227
L A+R + + AG + L+S+Q ++ S QDL A + + V
Sbjct: 507 RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV 566
Query: 228 EKGEGRLQTTHEELLL-----LRRERREHSLELERARSEAGEALSALRRLQR 274
+ E + E L L + E ++ERARS+ G+ A R R
Sbjct: 567 DGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR 618
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 80.9 bits (198), Expect = 3e-15
Identities = 124/503 (24%), Positives = 199/503 (39%), Gaps = 93/503 (18%)
Query: 32 ERRDSFLGGGPGPEEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLE 91
E + + G E+ +A + Q++ ++L L E+ + LE + + Q + Q L
Sbjct: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
Query: 92 --REER--LQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERA 147
R ER LQ++ +L R L+ R E E E + VEAL A
Sbjct: 824 TLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALE---------------RAA 868
Query: 148 RALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQ 207
R L++++ L+ QL A + + L E LR + +AL G+ L +Q +
Sbjct: 869 REKEALAKEHAGLAVQLVAAEREGRTLSEEATRLR--LEKEALEGS-----LFEVQRQLA 921
Query: 208 MLQSRRQDLEA--------------QIRGLREEV----EK--------GEGRLQTTHEEL 241
L++RR+ LEA ++ GLR+++ EK + +Q E
Sbjct: 922 QLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQ 981
Query: 242 LLLRRERREHSLELERARSE---AGEALSALRRLQRRVSELEEESRLQDADVSAASLQSE 298
LR +R H +L+R + E A L A R + + E+E L + L E
Sbjct: 982 ASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEE 1041
Query: 299 LAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEE 358
+A + D+G S K + S + + L T S A I E
Sbjct: 1042 IAALQQERDEG--------LLLAESEKQQALSLKESE--KTALSEKLMGTRHSLATISLE 1091
Query: 359 KEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSAL------------SD 406
E + Q ++ + +L EL ++LRAQ + A H+
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSEL---RDLRAQREEAAAAHAQEVRRLQEQARDLGKQ 1148
Query: 407 RDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRS 466
RD + +A EL QL + RD L RELL A ++K+ +QE G++++
Sbjct: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEA-QRKLRESQE------------GREVQR 1195
Query: 467 QRQKELSASASSSTPRRAAPRFS 489
Q EL S R A R S
Sbjct: 1196 QEAGELRRSLGEGAKEREALRRS 1218
Score = 80.9 bits (198), Expect = 3e-15
Identities = 116/471 (24%), Positives = 186/471 (39%), Gaps = 50/471 (10%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELG---KMLLERNEELRRQLETLSAQHLERE-----ERL 96
E+ DL +Q++ L A EL ++L + + LRR+L L AQ RE E
Sbjct: 1140 EQARDLG---KQRDSCLREAEELRTQLRLLEDARDGLRREL--LEAQRKLRESQEGREVQ 1194
Query: 97 QQENHELRRGL--------AARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERAR 148
+QE ELRR L A R + E R+ + + E + +L + EQ+ + E AR
Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254
Query: 149 ALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQM 208
LR Q + S+ E +REL LR Q + L L LQG +
Sbjct: 1255 TAVGKEAGELRTGLQEVERSRLEA--RRELQELRRQMKMLDSENTRLGRELAELQGRLAL 1312
Query: 209 LQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLE-----------LER 257
+ ++ + GLR+ + KGE L+ +EL + +R+ +E E LE
Sbjct: 1313 GERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEE 1372
Query: 258 ARSEAGEALSALRRLQRRVSELEEES-----RLQDADVSAASLQSELAHSLDDGDQGQGA 312
AR + L R L+ ++ E+ RL A+ A L++ELA + Q
Sbjct: 1373 ARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARV-----EVQRR 1427
Query: 313 DAPGDTPTTRSPKTR---KASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDE 369
A RS R +P P+P P + + E L +
Sbjct: 1428 AAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQ 1487
Query: 370 ISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERD 429
+L + A + + L SA +RDE + L+ QL + ERD
Sbjct: 1488 PPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERD 1547
Query: 430 SL---SRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASAS 477
S +R+L +A+ + + ++ +Q + Q S R+ E A+
Sbjct: 1548 SATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRAT 1598
Score = 72.8 bits (177), Expect = 7e-13
Identities = 114/435 (26%), Positives = 185/435 (42%), Gaps = 34/435 (7%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E E LA + L+ A G+ L E LR + E L E + +L Q
Sbjct: 870 EKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ------- 922
Query: 106 GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLA 165
L AR + EA L E L +L R +Q + +E+A EL Q L +++ A
Sbjct: 923 -LEARREQLEAEGQALLLAKETLTGELAGLR-QQIIATQEKASLDKELMAQKLVQAEREA 980
Query: 166 QASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLRE 225
QAS EQ E D R Q + +A A EL LQ + LQ +++L A++ +E
Sbjct: 981 QASLREQRAAHEEDLQRLQREKEA-AWRELEAERAQLQSQ---LQREQEELLARLEAEKE 1036
Query: 226 EVEKGEGRLQTTHEELLLLRRERREHSLELERARSEA-GEALSALRRLQRRVS-ELEEES 283
E+ + LQ +E LLL ++ +L L+ + A E L R +S E+E +
Sbjct: 1037 ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQK 1096
Query: 284 R-LQDADVSAASLQSELAHSLDD--GDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEI 340
R Q S + L L D + + A A + R + S +
Sbjct: 1097 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSC---L 1153
Query: 341 LEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLRE--ELQRQK--ELRAQEDP 396
E + RT L +LE+ L+ E+ Q +L+ +E E+QRQ+ ELR
Sbjct: 1154 REAEELRTQL---RLLEDAR---DGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGE 1207
Query: 397 GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQ--KVALTQELEAWQD 454
G AL +E + A++ + R+SL+ + +E A+ + + A+ +E +
Sbjct: 1208 GAKEREALRRSNEELRSAVK-KAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRT 1266
Query: 455 DMQVVIGQQLRSQRQ 469
+Q V +L ++R+
Sbjct: 1267 GLQEVERSRLEARRE 1281
Score = 72.0 bits (175), Expect = 1e-12
Identities = 131/505 (25%), Positives = 199/505 (39%), Gaps = 106/505 (20%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQ-------------HLER 92
E +LA LQ ++ + + L EELRRQ + L + LER
Sbjct: 604 EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
Query: 93 EER-----------LQQENHELRRGLA----------ARGAE-------WEARAVELEGD 124
R L +E E+R L+ A AE EA VELE
Sbjct: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELS 723
Query: 125 VEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRG- 183
+ LRA + + QDS LS+LS N L+Q ++ +L+ E AL+G
Sbjct: 724 MTKLRA----EEASLQDS-------LSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGR 772
Query: 184 --QCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQT----- 236
Q + +A E + RLE L+ E ++ RQ LE +R + E E +L T
Sbjct: 773 QRQAEQEATVAREEQERLEELRLEQEV---ARQGLEGSLRVAEQAQEALEQQLPTLRHER 829
Query: 237 --THEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAAS 294
E+L L R+ ELE+AR EA + AL R R L +E A
Sbjct: 830 SQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEH---------AG 880
Query: 295 LQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEI------LEPPKKRT 348
L +L A+ G T + + + R E+ LE +++
Sbjct: 881 LAVQLV----------AAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQL 930
Query: 349 SLSPAEILEEKEV---EVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALS 405
+L KE E+A L+ +I Q E SL +EL QK ++A+ + +L +
Sbjct: 931 EAEGQALLLAKETLTGELAGLRQQIIATQ-EKASLDKELMAQKLVQAEREAQASLREQRA 989
Query: 406 DRDEAVNK------ALELSLQLNRVSLERDSLSRE----LLRAIRQKVALTQELEAWQDD 455
+E + + A L+ R L+ L RE L R +K L++E+ A Q +
Sbjct: 990 AHEEDLQRLQREKEAAWRELEAERAQLQ-SQLQREQEELLARLEAEKEELSEEIAALQQE 1048
Query: 456 MQVVIGQQLRSQRQKELSASASSST 480
+ S++Q+ LS S T
Sbjct: 1049 RDEGL-LLAESEKQQALSLKESEKT 1072
Score = 70.9 bits (172), Expect = 3e-12
Identities = 124/486 (25%), Positives = 196/486 (40%), Gaps = 71/486 (14%)
Query: 49 DLALQLQQKEKDLLLAAELGKMLLERNEELRR-QLETLSAQHLEREERLQQENHELRR-- 105
+L L +++ EK L ++ K L E+ E L +L+ +A E E LQQ +L +
Sbjct: 401 ELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAV 460
Query: 106 ------GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERA--RALSELSEQN 157
G+ G+E A A G + L Q + GR R+ R S
Sbjct: 461 LSDSESGVQLSGSERTADASN--GSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSD- 517
Query: 158 LRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLE 217
S LA + Q ++ +RG+ +A LR +L + E + L+ + Q L
Sbjct: 518 ---SSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLR 574
Query: 218 AQIRGLREEVEKGEGRLQTTHEELLLLRRERRE--HSLEL-----ERARSEAGEALSALR 270
+ G + E + +Q LL RE+ HSL++ E R E + +A
Sbjct: 575 DKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQE 634
Query: 271 RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQG------------------A 312
L+R+ LEEE +DA A ++ EL S +Q +G A
Sbjct: 635 ELRRQRDRLEEEQ--EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRA 692
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEI--------LEPPKKRTSLSPAEILEEKEVE-- 362
D + +A + + E+ E + SLS L E +
Sbjct: 693 TLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDK 752
Query: 363 ------VAKLQDEISL-----QQAELQS--LREELQRQKELR-AQEDPGEALHSALSDRD 408
VA+L++E S +QAE ++ REE +R +ELR QE + L +L +
Sbjct: 753 LDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAE 812
Query: 409 EAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQR 468
+A +ALE QL + ER L +L + RQ QELE + + Q + R+ R
Sbjct: 813 QA-QEALE--QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAR 869
Query: 469 QKELSA 474
+KE A
Sbjct: 870 EKEALA 875
Score = 68.6 bits (166), Expect = 1e-11
Identities = 107/464 (23%), Positives = 185/464 (39%), Gaps = 71/464 (15%)
Query: 79 RRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSE 138
+RQL+ + R E Q LR+ L+ +E E RA LE ++ LR +
Sbjct: 530 KRQLQVQDMRG--RYEASQDLLGTLRKQLS--DSESERRA--LEEQLQRLRDKTDGAMQA 583
Query: 139 QQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTR 198
+D+ RE R L N LS++ + + + Q Q++ + LR + + A ELR +
Sbjct: 584 HEDAQREVQR----LRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQ 639
Query: 199 LESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERA 258
+ L+ E + + ++ ++E+ EG+ +EL+ +R +L+ +
Sbjct: 640 RDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDML 699
Query: 259 RSEAGEALSALRRLQRRVSELE--------EESRLQDADVSAASLQSELAHSLDDGD--- 307
++E E AL + + ELE EE+ LQD+ ++L LA D +
Sbjct: 700 QAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759
Query: 308 ----------QGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILE 357
QG+ A + R + R R + E LE
Sbjct: 760 AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819
Query: 358 EK-----------EVEVAKLQDEISLQQAELQSLREELQRQ----------KELRAQEDP 396
++ + ++A+L ++S ++ EL+ R E QRQ KE A+E
Sbjct: 820 QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHA 879
Query: 397 GEALHSALSDRD---------------EAVNKAL-ELSLQLNRVSLERDSLSRELLRAIR 440
G A+ ++R+ EA+ +L E+ QL ++ R+ L E +
Sbjct: 880 GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLL 939
Query: 441 QKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRA 484
K LT EL + Q +I Q ++ KEL A R A
Sbjct: 940 AKETLTGELAGLR---QQIIATQEKASLDKELMAQKLVQAEREA 980
Score = 68.2 bits (165), Expect = 2e-11
Identities = 130/549 (23%), Positives = 212/549 (38%), Gaps = 83/549 (15%)
Query: 2 SSPDGPSFPSGPLSGGASPSGDEGFF-PFVLERRDSFLGGGPGPEEPEDLALQLQQKEKD 60
S P P + P S P G F+ E R + + L QL + E +
Sbjct: 1486 SQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAE 1545
Query: 61 LLLAAELGKML---LERNEELRRQ-------------LETLSAQHLEREER--------- 95
A + L + +EE RR L+ S + ERE R
Sbjct: 1546 RDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATL 1605
Query: 96 ---LQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE 152
LQ ELR + ++ +A +LEGD L+ L S +R E
Sbjct: 1606 ERSLQATESELRAS-QEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGE 1664
Query: 153 LSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSR 212
L L LS + AQA Q LQ +D+L+ Q + L+ +E L G ++
Sbjct: 1665 LQRSRLGLSDREAQA----QALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES 1720
Query: 213 RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERR--EHSLELERARSEAG-EALSAL 269
L ++RGL E + + L +T ++ L L++ EH ++ + R +A +ALS
Sbjct: 1721 EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA 1780
Query: 270 RRLQRRVSELEEESRLQDADVSAASLQSE-----LAHSLDDGDQGQGA--DAPGDTPTTR 322
R+ + E + R + AD+ +++E L L +G+ A + R
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDER 1840
Query: 323 SPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK--------EVEVAKLQD------ 368
+ S Q + + LE K+ S + +++ +VE KL+
Sbjct: 1841 RLLQERLGSLQRALAQ--LEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
Query: 369 --------EISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQ 420
+ +L AEL+ L E ++ ++L AQ E HS +A + LEL +
Sbjct: 1899 LSAEKGRLDRTLTGAELE-LAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQE 1957
Query: 421 LNRVSLERDSLSREL---LRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASAS 477
+ R+ + R L RA RQ+V +E QV L+ Q Q+EL S++
Sbjct: 1958 VERLRSAQAQTERTLEARERAHRQRVRGLEE--------QV---STLKGQLQQELRRSSA 2006
Query: 478 SSTPRRAAP 486
+P P
Sbjct: 2007 PFSPPSGPP 2015
Score = 59.3 bits (142), Expect = 8e-09
Identities = 113/474 (23%), Positives = 181/474 (38%), Gaps = 107/474 (22%)
Query: 51 ALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQH---LEREERLQQENHELRRGL 107
AL+L+ E L + + L+ ++ ELRRQL+ A + L+ + QQ +L + L
Sbjct: 121 ALRLEPGE----LETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRL 176
Query: 108 AARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQA 167
+ +++ R ELE + +L +QR + ++ AL L E+ Q+ A
Sbjct: 177 QGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQ----QRSASL 232
Query: 168 SQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEV 227
+Q L+ +LD AG+ + E ++ R++LE + R E
Sbjct: 233 AQVNAMLREQLDQ----------AGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE 282
Query: 228 EKGEGRLQTTHEELLLLRRE----RR---------EHSL--------ELERARSEAGEAL 266
E H LLLL R+ RR E L RA EAG L
Sbjct: 283 ESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGL 342
Query: 267 SALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKT 326
S RL ESR + A A LQ++L L D + +
Sbjct: 343 STGLRL--------AESRAEAALEKQALLQAQLEEQLRD----------------KVLRE 378
Query: 327 RKASSPQPSPPEEILEPPKKRTSLSPA-EILEEKEVEVAKLQDEISLQQAELQSLREELQ 385
+ + Q + + + T L A + LE++ +E ++ +++ + L+SLR LQ
Sbjct: 379 KDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLR--LQ 436
Query: 386 RQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVAL 445
Q L ++ GE L L D +AV E +QL+ D+ + L
Sbjct: 437 EQAALETED--GEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSL---------- 484
Query: 446 TQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAP--RFSLRLGPGPA 497
+ LS + S PRR++P S R GP PA
Sbjct: 485 ------------------------RGLSGQRTPSPPRRSSPGRGRSPRRGPSPA 514
Score = 52.4 bits (124), Expect = 1e-06
Identities = 120/493 (24%), Positives = 189/493 (38%), Gaps = 83/493 (16%)
Query: 64 AAELGKMLLE---RNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEA---- 116
AAELG L R + L +L + Q E +L LRRGL A A
Sbjct: 1398 AAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPV 1457
Query: 117 -----RAVELEGDVEALRAQLGEQ---RSEQQDSGRERARALSELSEQNLRLSQQLAQAS 168
R EG E L + + S+ G + A +L + +R + L +
Sbjct: 1458 PGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGA--LREFL 1515
Query: 169 QTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVE 228
Q + QRE D LR Q A L +L ++ E SR + L+ + E
Sbjct: 1516 QELRSAQRERDELRTQTSA-------LNRQLAEMEAERDSATSRARQLQKAVAESEEARR 1568
Query: 229 KGEGRLQTTHEELLL----LRRERREHSLELERARS-----EAGEALSALRRLQRRVSEL 279
+GRL EL L +RR RE L++ + +A E S LR Q ++S++
Sbjct: 1569 SVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATE--SELRASQEKISKM 1626
Query: 280 E-------------------EESRLQDADVSAASLQSELAHS-LDDGDQGQGADAPGDTP 319
+ ESR ++ SL+ EL S L D+ A A D
Sbjct: 1627 KANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRV 1686
Query: 320 TTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILE-EKEVEVAKLQDEISLQQAELQ 378
+ R+ + + L + +L+ E E +V L + ++ A L
Sbjct: 1687 DSLQ---RQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLN 1743
Query: 379 SLREE-LQRQKELRAQEDPGEALHSALSDRDEAVNKALELS----------------LQL 421
S R++ L QK L A E + L L +A+++A + S L+L
Sbjct: 1744 STRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLEL 1803
Query: 422 NRVSLERD-SLSRELLRAIRQ-KVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSS 479
RV E RE+LR ++ + A ++ QD+ +++ Q+ Q+ L A
Sbjct: 1804 QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLL--QERLGSLQRAL---AQLE 1858
Query: 480 TPRRAAPRFSLRL 492
+R R +LRL
Sbjct: 1859 AEKREVERSALRL 1871
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 80.5 bits (197), Expect = 3e-15
Identities = 116/462 (25%), Positives = 192/462 (41%), Gaps = 56/462 (12%)
Query: 35 DSFLGGGPGPEEPEDLALQLQQKEKDL--LLAAELGKMLLERNEELRRQLETLSAQHLER 92
+S G E + QL++K + L L A+ K+ + E R E A+ E
Sbjct: 718 ESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEA 777
Query: 93 E-----ERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERA 147
E E E LR + A G E E+ + E E VEAL A E+R +++ R RA
Sbjct: 778 EAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRA 837
Query: 148 RALSELSEQNLRLSQQLAQASQTEQELQR-ELDALRGQCQAQALAGAELRTRLESLQGEN 206
+ SE +E+ +++ + + E E +R E +AL+ + + + G EL RLE LQ E
Sbjct: 838 Q--SEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQREL 895
Query: 207 QMLQSRRQDL-------EAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERAR 259
+ RQ+ + +GL + +E T+ EE L+ E + +L+LE
Sbjct: 896 EQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALM---ELKTRALQLEEEL 952
Query: 260 SEAGEALSALRRLQRRVSELEEESRLQDADV---------SAASLQSELAHSLDDGDQGQ 310
+ + + L +R +L E ++ +V A+LQ +L H +GQ
Sbjct: 953 FQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHL-----EGQ 1007
Query: 311 GADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEI 370
G R E+ + + + E+LEE+ + Q+E
Sbjct: 1008 LGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEET 1067
Query: 371 SLQQ----------AELQSLREE-----LQRQKELRAQEDPGEALHSALSDRDEAVNKAL 415
QQ A+LQ +E L R ++L+A E H L R E + +A
Sbjct: 1068 RGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQL-QAQ 1126
Query: 416 ELSLQLNRVSL--ERDSLSRELLRAIRQKVALTQELEAWQDD 455
S++ V+L ER+ L ++ RQ+ L +EL Q +
Sbjct: 1127 RASVEAQEVALLAERERLMQD---GHRQR-GLEEELRRLQSE 1164
Score = 77.0 bits (188), Expect = 4e-14
Identities = 133/500 (26%), Positives = 215/500 (43%), Gaps = 59/500 (11%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQEN--HE 102
EE E + + + +L A GK L R E L+R+LE + LER+E L+++ H+
Sbjct: 858 EEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAA---LERQEFLREKESQHQ 914
Query: 103 LRRGLAAR-GAEWEA--------------RAVELEGDVEALR---AQLG-EQRSEQQDSG 143
+GL R AE +A RA++LE ++ LR A LG ++R+E Q
Sbjct: 915 RYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVE 974
Query: 144 RERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQ 203
+ R L E+ N L + A Q L+ +L +L+G+ Q L + LQ
Sbjct: 975 TQNVR-LIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQ 1033
Query: 204 GENQMLQSRRQD-------LEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELE 256
E +L+ + Q+ LE ++R R+ E+ G+ Q + L + +R ELE
Sbjct: 1034 AEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELE 1093
Query: 257 RARSEAGEALSALRRLQRRVSELE---EESRLQDADVSA--ASLQSELAHSLDDGDQGQG 311
+ + +R L+ EL+ E+ + Q A V A +L +E + DG + +G
Sbjct: 1094 GLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG 1153
Query: 312 ADAPGDTPTTRSPKTRKASSPQPSPPEEIL-EPPKKRTSLSPAEILEEKEVEVAKLQDEI 370
+ + + + + E+ E + R L+ E LE ++E+ Q
Sbjct: 1154 LEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLE-LERAQLEMQSQQLRE 1212
Query: 371 SLQQAELQSLREELQRQ--KELR-AQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLE 427
S QQ +L + R Q + +LR AQE+ L + + + LE SL+
Sbjct: 1213 SNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLE------S 1266
Query: 428 RDSLSRELLRAIRQKVALTQE----LEAWQDDMQVVIGQQLRSQRQKELSASASS----S 479
RD L RE + Q AL +E +E D +V+ + + R K+ S A
Sbjct: 1267 RDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVL--EPVPLPRTKKGSWLADKVKRLM 1324
Query: 480 TPRR-AAPRFSLRLGPGPAG 498
PRR P LRLG AG
Sbjct: 1325 RPRREGGPPGGLRLGADGAG 1344
Score = 68.9 bits (167), Expect = 1e-11
Identities = 111/478 (23%), Positives = 189/478 (39%), Gaps = 44/478 (9%)
Query: 7 PSFPSGPLSGGASPSGDEGFFPFVLERRDSFLGGGPGPEEPEDLALQLQQKEKDLLLAAE 66
P G G +P G+ P R PGP EP + L+ Q+ L +
Sbjct: 617 PQLLGGETEGREAPQGE--LVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL---D 671
Query: 67 LGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVE 126
L E E +R T+ ++ ++ + E++ E A V + E
Sbjct: 672 LATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGV---AEQE 728
Query: 127 ALRAQLGEQRSEQQDSGRE---RARALSELSEQNLRLSQQLAQASQTEQELQRELDALRG 183
ALR ++ + R + + G E +AR L + + RLS++LAQA + E E RE
Sbjct: 729 ALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHRE------ 782
Query: 184 QCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGL------REEVEKGEGRL--- 234
+AQA A LR E+++ Q L+S Q+ EA + L R + E+ RL
Sbjct: 783 -AEAQAWEQARLR---EAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQ 838
Query: 235 -QTTHEELLLLRRERREHSLELERARSEAGEALSAL--------RRLQRRVSELEEESRL 285
+ E + +L E R+H E ER R E EAL A + L R+ L+ E
Sbjct: 839 SEAAEERMQVLESEGRQHLEEAERERREK-EALQAELEKAVVRGKELGARLEHLQRELEQ 897
Query: 286 QDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPK 345
+ + E H G + + T++ + + EE+ + +
Sbjct: 898 AALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQ 957
Query: 346 KRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALS 405
L P + E + VE ++ I ++++ + E+ Q +L+ E +L
Sbjct: 958 GPAGLGPKKRAEPQLVETQNVR-LIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQ 1016
Query: 406 DRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQ 463
+ +A E S +R+ E+ L + R+ L +E+ A + + GQQ
Sbjct: 1017 ELLLQSQRAQEHS---SRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQ 1071
Score = 53.1 bits (126), Expect = 6e-07
Identities = 103/410 (25%), Positives = 166/410 (40%), Gaps = 58/410 (14%)
Query: 56 QKEKDLLLAAELGKMLLERN-EELRRQLETLSAQHLEREERLQQENHELRR--GLAARGA 112
+++ +LLL ++ LE LR++ + LS Q +R E ++E LR G R
Sbjct: 275 EEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQ-AKRAELYREEAEALRERAGRLPRLQ 333
Query: 113 EWEARAVELEGDVEALRAQLGEQR-------------SEQQDSGRERARALSELSEQNLR 159
E R E EA ++QL E+R EQ ++ RER L E +NL
Sbjct: 334 EELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLL 393
Query: 160 LSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLE-------------SLQGEN 206
L +L +A ELD+LR Q A EL L+ L G
Sbjct: 394 LRTRLGEA-------HAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAA 446
Query: 207 QMLQSRRQDLEA-QIRGLREEVEKGEGRLQTTH----EELLLLRRERREHSLELERARSE 261
LQ ++ EA ++R L E + G LQ + LL R + L + E
Sbjct: 447 PSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPV---LEE 503
Query: 262 AGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT 321
A + A + + + + Q D++ +L S L S + ++P
Sbjct: 504 APQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQ 563
Query: 322 RSPKTRKAS--SPQPS-PPEEILEPPKK---RTSL-SPAEILEEK----EVEVAK-LQDE 369
+ +AS SPQ S P E E P+K R+SL SPA + + +++ + L E
Sbjct: 564 AAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGE 623
Query: 370 ISLQQAELQSLREELQRQKELRAQEDPGEALHSALS-DRDEAVNKALELS 418
++A L E ++ + PG + S++ + E N+ L+L+
Sbjct: 624 TEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLA 673
Score = 40.0 bits (92), Expect = 0.005
Identities = 48/174 (27%), Positives = 80/174 (45%), Gaps = 29/174 (16%)
Query: 137 SEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELR 196
+E + R LS+L+ + +Q+LA E L+RE LR + ++A A
Sbjct: 200 AELEMLSRSLMGTLSKLARERDLGAQRLA-----ELLLEREPLCLRPEAPSRAPA----- 249
Query: 197 TRLESLQGENQMLQSRRQDLEAQIRGLREEVEK-------GEGRLQTTHEELLLLRRERR 249
+G + L + + +AQ+R LR+E+E+ + +Q E+ LR+E +
Sbjct: 250 ------EGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQ 303
Query: 250 EHSLELERARSEAGEALSALRRLQRRVSELEEE-----SRLQDADVSAASLQSE 298
S + +RA EA ALR R+ L+EE RLQ A+ + L+ E
Sbjct: 304 ALSGQAKRAELYREEA-EALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEE 356
Score = 36.6 bits (83), Expect = 0.055
Identities = 68/266 (25%), Positives = 105/266 (39%), Gaps = 40/266 (15%)
Query: 190 LAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERR 249
LA AEL SL G L +R +DL AQ L E + + E L E E
Sbjct: 197 LAPAELEMLSRSLMGTLSKL-ARERDLGAQ--RLAELLLEREP-LCLRPEAPSRAPAEGP 252
Query: 250 EHSLELERARSEAGEALSALRRLQRRVSELEEESRLQ-DADVSAASLQSELAHSLDDGDQ 308
H L L+ A ++A LRRL++ ELEE++ L D+ L++E+ +
Sbjct: 253 SHHLALQLANAKA-----QLRRLRQ---ELEEKAELLLDSQAEVQGLEAEIRRLRQEAQA 304
Query: 309 GQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEI----LEEKEVEVA 364
G + + R+ + P EE+ + R L AE LEE+ V
Sbjct: 305 LSGQAKRAELYREEAEALRERAGRLPRLQEELR---RCRERLQAAEAYKSQLEEERVLSG 361
Query: 365 KLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRV 424
L+ +L + +L++ RE R E + + L L +L
Sbjct: 362 VLEASKALLEEQLEAARERCARLHETQREN--------------------LLLRTRLGEA 401
Query: 425 SLERDSLSRELLRAIRQKVALTQELE 450
E DSL ++ + + V L EL+
Sbjct: 402 HAELDSLRHQVDQLAEENVELELELQ 427
Score = 30.0 bits (66), Expect = 5.2
Identities = 63/275 (22%), Positives = 105/275 (38%), Gaps = 34/275 (12%)
Query: 232 GRLQTTHEE---LLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDA 288
GRL+ ++E LL+L +L + EA E L + RL S E L
Sbjct: 99 GRLRDFYQEELQLLILSPPPDLQTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIR 158
Query: 289 DVSAASL--QSELAHSLDDGDQ---GQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEP 343
+ SL QSELA ++ + Q G G P +P + S L
Sbjct: 159 HIQGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLAR 218
Query: 344 PKKRTSLSPAEILEEKEVEVAK---------------LQDEISLQQAELQSLREELQRQK 388
+ + AE+L E+E + L +++ +A+L+ LR+EL+ +
Sbjct: 219 ERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKA 278
Query: 389 ELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVA---- 444
EL A EA + L Q +R L RE A+R++
Sbjct: 279 ELLLDS-------QAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPR 331
Query: 445 LTQELEAWQDDMQVVIGQQLRSQRQKELSASASSS 479
L +EL ++ +Q + + + ++ LS +S
Sbjct: 332 LQEELRRCRERLQAAEAYKSQLEEERVLSGVLEAS 366
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 79.7 bits (195), Expect = 6e-15
Identities = 95/437 (21%), Positives = 181/437 (41%), Gaps = 43/437 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGA 112
+LQQ+ DL++ + + L+ E+ +R+ + L A+ E+ + + + R A
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAR 1479
Query: 113 EWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
E E +A+ L +E E A EL N L ++ ++
Sbjct: 1480 EKETKALSLARALE------------------EALEAKEELERTNKMLKAEMEDLVSSKD 1521
Query: 173 ELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKG-E 231
++ + + L +A E++T+LE L+ E Q + + LE ++ L+ + E+ +
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 232 GRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVS--ELEEESRLQDAD 289
R + E+ L+R+ E+ ELE R + A +A ++L+ + EL+ +S ++ +
Sbjct: 1582 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 290 VSAASLQSELAHSLDDGDQGQGADAPGD------TPTTRSPKTRKASSPQPSPPEEILEP 343
+ L+ A D + + A A D + K+ +A Q E
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 344 PKKRTSLSPAEILEEKEVEVA---KLQDEISLQQAELQSLREELQRQK--------ELRA 392
+K+ L E+ EE ++ LQDE +A + L EEL+ ++ +R
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 393 QEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALT-QELEA 451
E L + L+ K QL R + E S E+ A++ K T LEA
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 452 WQDDMQVVIGQQLRSQR 468
++ + Q+ R ++
Sbjct: 1822 KIAQLEEQVEQEAREKQ 1838
Score = 78.6 bits (192), Expect = 1e-14
Identities = 98/464 (21%), Positives = 195/464 (42%), Gaps = 54/464 (11%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQ---------------- 88
+E + + ++KE L A + LE EEL R + L A+
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 89 HLEREER-LQQENHELRRGLAARGAEWEA---RAVELEGDVEALRAQLGEQRSEQQDSGR 144
LE+ +R L+ + E++ L E +A + LE +++AL+ Q + +
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 145 ERARALS-ELSEQNLRLS---QQLAQASQTEQELQRELDALRGQCQAQALAGAE------ 194
E+ R L +L E L +Q A A+ +++L+ +L L Q + A+ G E
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS-AIKGREEAIKQL 1647
Query: 195 --LRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHS 252
L+ +++ Q E + ++ R ++ A + ++ + E L E+L R R++
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 253 LELERARSEAGEALSA-------LRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDD 305
LE E E +LS RRL+ R+++LEEE L++ + ++ + +
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE--LEEEQGNMEAMSDRVRKATQQ 1765
Query: 306 GDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAK 365
+Q A + ++ R+ Q L + + E ++A+
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 366 LQDEISLQ----QAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVN-KALELSLQ 420
L++++ + QA +SL+++ ++ KE+ Q + + ++ E N + +L Q
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 421 L-------NRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQ 457
L R++ R L REL A A+ +E+ A + ++
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 75.1 bits (183), Expect = 1e-13
Identities = 97/416 (23%), Positives = 174/416 (41%), Gaps = 53/416 (12%)
Query: 48 EDLALQLQQKEKDLLLAAELGKMLLERNEE-----LRRQLETLSAQHLEREERLQQENHE 102
E++ QL++ E D L A E K+ LE N + R L+ Q+ E+ +LQ++ HE
Sbjct: 1542 EEMKTQLEELE-DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 103 L---------RRGLAA---RGAEWEARAVELEGD------------VEALRAQLGEQRSE 138
+R LAA + E + + +EL+ D + L+AQ+ + + E
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 139 QQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTR 198
+D+ R + E + A Q +++L A R + QA L EL
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---AERARKQAD-LEKEELAEE 1716
Query: 199 LESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERA 258
L S LQ ++ LEA+I L EE+E+ +G ++ + + ++ + S EL
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 259 RSEAGEALSALRRLQRRVSELEEESRLQDADVSA------ASLQSELAHSLDDGDQGQGA 312
RS A + SA ++L+R+ EL + + V + A+L++++A + +Q
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISL 372
+ K K Q ++ E K++ A + + K L
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR----------QL 1886
Query: 373 QQAELQSLREELQR---QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVS 425
++AE +S R R Q+EL + EA+ ++ + + E S +R S
Sbjct: 1887 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRS 1942
Score = 74.7 bits (182), Expect = 2e-13
Identities = 100/447 (22%), Positives = 196/447 (43%), Gaps = 55/447 (12%)
Query: 52 LQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQH--LEREERLQQENHELRRGLAA 109
LQ+ ++E+++ + + ER ++ +L+ L +H L E+ L QE + L A
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 110 RGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQ 169
E R + ++E + ++ + E++D G++ ++++Q L L +QL +
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 170 TEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQI----RGLRE 225
Q+LQ E + + +L + + +N L R+ LE +I L E
Sbjct: 965 ARQKLQLEKVTAEAKIK-------KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 226 EVEKGEG--RLQTTHE------ELLLLRRERREHSLE--LERARSEAGEALSALRRLQRR 275
E EK + +L+ HE E+ L + E+ LE + +A + + LQ +
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 276 VSELEEESRLQDADVSA--ASLQSELAHSLDDGD-----QGQGADAPGDTPTTRSPKTRK 328
++EL+ + ++ ++ A A L E+A + +G +D D + R+ + +
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 329 ASSPQPSPPE-EILEPPKKRTSLSPAEILE-----EKEVEVAK--LQDEISLQQAELQSL 380
+ E E L+ + T S A E E+EV V K L +E +A++Q +
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 381 REELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIR 440
RQK +A E+ E L K + +L N+ +LE++ + +L +R
Sbjct: 1198 -----RQKHAQAVEELTEQLEQF---------KRAKANLDKNKQTLEKE--NADLAGELR 1241
Query: 441 QKVALTQELEAWQDDMQVVIGQQLRSQ 467
QE+E + ++ + Q+L+S+
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQV-QELQSK 1267
Score = 66.2 bits (160), Expect = 7e-11
Identities = 98/485 (20%), Positives = 203/485 (41%), Gaps = 66/485 (13%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE L QLQ + + A E+ L + +EL L + A+ E E+R QQ E R
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-R 945
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQ- 163
+ +A + + E + E EA R +L ++ + ++ + + +QN +LS++
Sbjct: 946 KKMAQQMLDLEEQLEE----EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 164 ---------LAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQ 214
L E+E + L L+ + ++ +EL RL+ + Q L+ ++
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI---SELEVRLKKEEKSRQELEKLKR 1058
Query: 215 DLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQR 274
LE E++ + ++ +L E + L+ ++ AL +R L+
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 275 RVSELEE------------ESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT- 321
+S+L+E E + +D +L++EL +LD Q A + T
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 322 -----------RSPKTRKASSPQPSPPEEILEPPK--KRTSLSPAEILEEKEVEVAKLQD 368
+ ++ EE+ E + KR + + + E E A L
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 369 EISL---QQAELQSLREELQRQ-KELRAQEDPGEALHSALSDR---------------DE 409
E+ + + E++ +++L+ Q +EL+++ GE + L+D+ +E
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 410 AVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALT---QELEAWQDDMQVVIGQQLRS 466
A KA++L+ + +S + L RQK+ ++ ++LE ++ +Q + +++ +
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 467 QRQKE 471
++ E
Sbjct: 1359 KQNLE 1363
Score = 62.8 bits (151), Expect = 7e-10
Identities = 74/350 (21%), Positives = 161/350 (46%), Gaps = 29/350 (8%)
Query: 135 QRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAE 194
Q + Q++ + + L + E+ + +L + Q +L E + L+ Q QA+ AE
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 195 LRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLE 254
L + Q L+ ++EA+ L EE ++G ++L R++ + L+
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEAR---LEEEEDRG--------QQLQAERKKMAQQMLD 954
Query: 255 LERARSEAGEALSALR----RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQ 310
LE E A L+ + ++ +LE+E + D + S + +L L++
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEERISDL 1011
Query: 311 GADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK-EVEVAKLQDE 369
+ + ++ T+ + + E + K+ S E L+ K E + + ++
Sbjct: 1012 TTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 370 ISLQQAELQSLREEL-QRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLER 428
I+ QA++ L+ +L ++++EL+A L ++ ++ A+ K EL ++ + +
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAAL---ARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 429 DSLSRELLRAIRQKVALTQELEAWQDDMQVVIG-----QQLRSQRQKELS 473
DS +A +QK L +ELEA + +++ + Q+LR++R++E++
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Score = 60.5 bits (145), Expect = 4e-09
Identities = 98/440 (22%), Positives = 184/440 (41%), Gaps = 66/440 (15%)
Query: 76 EELRRQLETLS---AQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQL 132
EEL QLE A + ++ L++EN +L L G + E+E + L AQ+
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ----EVEHKKKKLEAQV 1261
Query: 133 GEQRSEQQDSGRERARA---LSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQ-AQ 188
E +S+ D R RA + +L + ++ L +A +L +++ +L Q Q Q
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 189 ALAGAELR------TRLESLQGENQMLQSR-------RQDLEAQIRGLREEVEKGEGRLQ 235
L E R T+L L+ E LQ + +Q+LE I L ++ + +LQ
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 236 TTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASL 295
+ L ++ E+E + E +A +L++ + L++E L D V +
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE--LDDLVVDLDN- 1438
Query: 296 QSELAHSLDD-------------------GDQGQGADAPGDTPTTRSPKTRKASSPQPSP 336
Q +L +L+ D+ A+A T++ +A
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 337 PEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDP 396
EE LE K +++ K+ +V K E+ + L++ EE++ Q L ED
Sbjct: 1499 KEE-LERTNKMLKAEMEDLVSSKD-DVGKNVHELEKSKRALETQMEEMKTQ--LEELEDE 1554
Query: 397 GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDM 456
+A A LE+++Q + ERD +R+ +++ L ++L ++ ++
Sbjct: 1555 LQATEDA--------KLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETEL 1605
Query: 457 QVVIGQQLRSQRQKELSASA 476
+ ++Q+ L+A+A
Sbjct: 1606 E-------DERKQRALAAAA 1618
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 79.7 bits (195), Expect = 6e-15
Identities = 95/437 (21%), Positives = 181/437 (41%), Gaps = 43/437 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGA 112
+LQQ+ DL++ + + L+ E+ +R+ + L A+ E+ + + + R A
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAR 1486
Query: 113 EWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
E E +A+ L +E E A EL N L ++ ++
Sbjct: 1487 EKETKALSLARALE------------------EALEAKEELERTNKMLKAEMEDLVSSKD 1528
Query: 173 ELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKG-E 231
++ + + L +A E++T+LE L+ E Q + + LE ++ L+ + E+ +
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 232 GRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVS--ELEEESRLQDAD 289
R + E+ L+R+ E+ ELE R + A +A ++L+ + EL+ +S ++ +
Sbjct: 1589 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 290 VSAASLQSELAHSLDDGDQGQGADAPGD------TPTTRSPKTRKASSPQPSPPEEILEP 343
+ L+ A D + + A A D + K+ +A Q E
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 344 PKKRTSLSPAEILEEKEVEVA---KLQDEISLQQAELQSLREELQRQK--------ELRA 392
+K+ L E+ EE ++ LQDE +A + L EEL+ ++ +R
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 393 QEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALT-QELEA 451
E L + L+ K QL R + E S E+ A++ K T LEA
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 452 WQDDMQVVIGQQLRSQR 468
++ + Q+ R ++
Sbjct: 1829 KIAQLEEQVEQEAREKQ 1845
Score = 78.6 bits (192), Expect = 1e-14
Identities = 98/464 (21%), Positives = 195/464 (42%), Gaps = 54/464 (11%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQ---------------- 88
+E + + ++KE L A + LE EEL R + L A+
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 89 HLEREER-LQQENHELRRGLAARGAEWEA---RAVELEGDVEALRAQLGEQRSEQQDSGR 144
LE+ +R L+ + E++ L E +A + LE +++AL+ Q + +
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 145 ERARALS-ELSEQNLRLS---QQLAQASQTEQELQRELDALRGQCQAQALAGAE------ 194
E+ R L +L E L +Q A A+ +++L+ +L L Q + A+ G E
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS-AIKGREEAIKQL 1654
Query: 195 --LRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHS 252
L+ +++ Q E + ++ R ++ A + ++ + E L E+L R R++
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 253 LELERARSEAGEALSA-------LRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDD 305
LE E E +LS RRL+ R+++LEEE L++ + ++ + +
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE--LEEEQGNMEAMSDRVRKATQQ 1772
Query: 306 GDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAK 365
+Q A + ++ R+ Q L + + E ++A+
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 366 LQDEISLQ----QAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVN-KALELSLQ 420
L++++ + QA +SL+++ ++ KE+ Q + + ++ E N + +L Q
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 421 L-------NRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQ 457
L R++ R L REL A A+ +E+ A + ++
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 75.1 bits (183), Expect = 1e-13
Identities = 97/416 (23%), Positives = 174/416 (41%), Gaps = 53/416 (12%)
Query: 48 EDLALQLQQKEKDLLLAAELGKMLLERNEE-----LRRQLETLSAQHLEREERLQQENHE 102
E++ QL++ E D L A E K+ LE N + R L+ Q+ E+ +LQ++ HE
Sbjct: 1549 EEMKTQLEELE-DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 103 L---------RRGLAA---RGAEWEARAVELEGD------------VEALRAQLGEQRSE 138
+R LAA + E + + +EL+ D + L+AQ+ + + E
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 139 QQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTR 198
+D+ R + E + A Q +++L A R + QA L EL
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---AERARKQAD-LEKEELAEE 1723
Query: 199 LESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERA 258
L S LQ ++ LEA+I L EE+E+ +G ++ + + ++ + S EL
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 259 RSEAGEALSALRRLQRRVSELEEESRLQDADVSA------ASLQSELAHSLDDGDQGQGA 312
RS A + SA ++L+R+ EL + + V + A+L++++A + +Q
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 313 DAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISL 372
+ K K Q ++ E K++ A + + K L
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR----------QL 1893
Query: 373 QQAELQSLREELQR---QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVS 425
++AE +S R R Q+EL + EA+ ++ + + E S +R S
Sbjct: 1894 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRS 1949
Score = 74.7 bits (182), Expect = 2e-13
Identities = 100/447 (22%), Positives = 196/447 (43%), Gaps = 55/447 (12%)
Query: 52 LQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQH--LEREERLQQENHELRRGLAA 109
LQ+ ++E+++ + + ER ++ +L+ L +H L E+ L QE + L A
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 110 RGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQ 169
E R + ++E + ++ + E++D G++ ++++Q L L +QL +
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 170 TEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQI----RGLRE 225
Q+LQ E + + +L + + +N L R+ LE +I L E
Sbjct: 972 ARQKLQLEKVTAEAKIK-------KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 226 EVEKGEG--RLQTTHE------ELLLLRRERREHSLE--LERARSEAGEALSALRRLQRR 275
E EK + +L+ HE E+ L + E+ LE + +A + + LQ +
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 276 VSELEEESRLQDADVSA--ASLQSELAHSLDDGD-----QGQGADAPGDTPTTRSPKTRK 328
++EL+ + ++ ++ A A L E+A + +G +D D + R+ + +
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 329 ASSPQPSPPE-EILEPPKKRTSLSPAEILE-----EKEVEVAK--LQDEISLQQAELQSL 380
+ E E L+ + T S A E E+EV V K L +E +A++Q +
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 381 REELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIR 440
RQK +A E+ E L K + +L N+ +LE++ + +L +R
Sbjct: 1205 -----RQKHAQAVEELTEQLEQF---------KRAKANLDKNKQTLEKE--NADLAGELR 1248
Query: 441 QKVALTQELEAWQDDMQVVIGQQLRSQ 467
QE+E + ++ + Q+L+S+
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQV-QELQSK 1274
Score = 66.2 bits (160), Expect = 7e-11
Identities = 98/485 (20%), Positives = 203/485 (41%), Gaps = 66/485 (13%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE L QLQ + + A E+ L + +EL L + A+ E E+R QQ E R
Sbjct: 894 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-R 952
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQ- 163
+ +A + + E + E EA R +L ++ + ++ + + +QN +LS++
Sbjct: 953 KKMAQQMLDLEEQLEE----EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 164 ---------LAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQ 214
L E+E + L L+ + ++ +EL RL+ + Q L+ ++
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI---SELEVRLKKEEKSRQELEKLKR 1065
Query: 215 DLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQR 274
LE E++ + ++ +L E + L+ ++ AL +R L+
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 275 RVSELEE------------ESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT- 321
+S+L+E E + +D +L++EL +LD Q A + T
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 322 -----------RSPKTRKASSPQPSPPEEILEPPK--KRTSLSPAEILEEKEVEVAKLQD 368
+ ++ EE+ E + KR + + + E E A L
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 369 EISL---QQAELQSLREELQRQ-KELRAQEDPGEALHSALSDR---------------DE 409
E+ + + E++ +++L+ Q +EL+++ GE + L+D+ +E
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 410 AVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALT---QELEAWQDDMQVVIGQQLRS 466
A KA++L+ + +S + L RQK+ ++ ++LE ++ +Q + +++ +
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 467 QRQKE 471
++ E
Sbjct: 1366 KQNLE 1370
Score = 62.8 bits (151), Expect = 7e-10
Identities = 74/350 (21%), Positives = 161/350 (46%), Gaps = 29/350 (8%)
Query: 135 QRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAE 194
Q + Q++ + + L + E+ + +L + Q +L E + L+ Q QA+ AE
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 195 LRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLE 254
L + Q L+ ++EA+ L EE ++G ++L R++ + L+
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEAR---LEEEEDRG--------QQLQAERKKMAQQMLD 961
Query: 255 LERARSEAGEALSALR----RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQ 310
LE E A L+ + ++ +LE+E + D + S + +L L++
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEERISDL 1018
Query: 311 GADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK-EVEVAKLQDE 369
+ + ++ T+ + + E + K+ S E L+ K E + + ++
Sbjct: 1019 TTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 370 ISLQQAELQSLREEL-QRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLER 428
I+ QA++ L+ +L ++++EL+A L ++ ++ A+ K EL ++ + +
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAAL---ARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 429 DSLSRELLRAIRQKVALTQELEAWQDDMQVVIG-----QQLRSQRQKELS 473
DS +A +QK L +ELEA + +++ + Q+LR++R++E++
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Score = 60.5 bits (145), Expect = 4e-09
Identities = 98/440 (22%), Positives = 184/440 (41%), Gaps = 66/440 (15%)
Query: 76 EELRRQLETLS---AQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQL 132
EEL QLE A + ++ L++EN +L L G + E+E + L AQ+
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ----EVEHKKKKLEAQV 1268
Query: 133 GEQRSEQQDSGRERARA---LSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQ-AQ 188
E +S+ D R RA + +L + ++ L +A +L +++ +L Q Q Q
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 189 ALAGAELR------TRLESLQGENQMLQSR-------RQDLEAQIRGLREEVEKGEGRLQ 235
L E R T+L L+ E LQ + +Q+LE I L ++ + +LQ
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 236 TTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASL 295
+ L ++ E+E + E +A +L++ + L++E L D V +
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE--LDDLVVDLDN- 1445
Query: 296 QSELAHSLDD-------------------GDQGQGADAPGDTPTTRSPKTRKASSPQPSP 336
Q +L +L+ D+ A+A T++ +A
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 337 PEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDP 396
EE LE K +++ K+ +V K E+ + L++ EE++ Q L ED
Sbjct: 1506 KEE-LERTNKMLKAEMEDLVSSKD-DVGKNVHELEKSKRALETQMEEMKTQ--LEELEDE 1561
Query: 397 GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDM 456
+A A LE+++Q + ERD +R+ +++ L ++L ++ ++
Sbjct: 1562 LQATEDA--------KLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETEL 1612
Query: 457 QVVIGQQLRSQRQKELSASA 476
+ ++Q+ L+A+A
Sbjct: 1613 E-------DERKQRALAAAA 1625
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 79.7 bits (195), Expect = 6e-15
Identities = 95/437 (21%), Positives = 181/437 (41%), Gaps = 43/437 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGA 112
+LQQ+ DL++ + + L+ E+ +R+ + L A+ E+ + + + R A
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAR 1486
Query: 113 EWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
E E +A+ L +E E A EL N L ++ ++
Sbjct: 1487 EKETKALSLARALE------------------EALEAKEELERTNKMLKAEMEDLVSSKD 1528
Query: 173 ELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKG-E 231
++ + + L +A E++T+LE L+ E Q + + LE ++ L+ + E+ +
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 232 GRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVS--ELEEESRLQDAD 289
R + E+ L+R+ E+ ELE R + A +A ++L+ + EL+ +S ++ +
Sbjct: 1589 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 290 VSAASLQSELAHSLDDGDQGQGADAPGD------TPTTRSPKTRKASSPQPSPPEEILEP 343
+ L+ A D + + A A D + K+ +A Q E
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 344 PKKRTSLSPAEILEEKEVEVA---KLQDEISLQQAELQSLREELQRQK--------ELRA 392
+K+ L E+ EE ++ LQDE +A + L EEL+ ++ +R
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 393 QEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALT-QELEA 451
E L + L+ K QL R + E S E+ A++ K T LEA
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 452 WQDDMQVVIGQQLRSQR 468
++ + Q+ R ++
Sbjct: 1829 KIAQLEEQVEQEAREKQ 1845
Score = 78.6 bits (192), Expect = 1e-14
Identities = 98/464 (21%), Positives = 195/464 (42%), Gaps = 54/464 (11%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQ---------------- 88
+E + + ++KE L A + LE EEL R + L A+
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 89 HLEREER-LQQENHELRRGLAARGAEWEA---RAVELEGDVEALRAQLGEQRSEQQDSGR 144
LE+ +R L+ + E++ L E +A + LE +++AL+ Q + +
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 145 ERARALS-ELSEQNLRLS---QQLAQASQTEQELQRELDALRGQCQAQALAGAE------ 194
E+ R L +L E L +Q A A+ +++L+ +L L Q + A+ G E
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS-AIKGREEAIKQL 1654
Query: 195 --LRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHS 252
L+ +++ Q E + ++ R ++ A + ++ + E L E+L R R++
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 253 LELERARSEAGEALSA-------LRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDD 305
LE E E +LS RRL+ R+++LEEE L++ + ++ + +
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE--LEEEQGNMEAMSDRVRKATQQ 1772
Query: 306 GDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAK 365
+Q A + ++ R+ Q L + + E ++A+
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 366 LQDEISLQ----QAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVN-KALELSLQ 420
L++++ + QA +SL+++ ++ KE+ Q + + ++ E N + +L Q
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 421 L-------NRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQ 457
L R++ R L REL A A+ +E+ A + ++
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 74.7 bits (182), Expect = 2e-13
Identities = 100/447 (22%), Positives = 196/447 (43%), Gaps = 55/447 (12%)
Query: 52 LQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQH--LEREERLQQENHELRRGLAA 109
LQ+ ++E+++ + + ER ++ +L+ L +H L E+ L QE + L A
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 110 RGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQ 169
E R + ++E + ++ + E++D G++ ++++Q L L +QL +
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 170 TEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQI----RGLRE 225
Q+LQ E + + +L + + +N L R+ LE +I L E
Sbjct: 972 ARQKLQLEKVTAEAKIK-------KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 226 EVEKGEG--RLQTTHE------ELLLLRRERREHSLE--LERARSEAGEALSALRRLQRR 275
E EK + +L+ HE E+ L + E+ LE + +A + + LQ +
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 276 VSELEEESRLQDADVSA--ASLQSELAHSLDDGD-----QGQGADAPGDTPTTRSPKTRK 328
++EL+ + ++ ++ A A L E+A + +G +D D + R+ + +
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 329 ASSPQPSPPE-EILEPPKKRTSLSPAEILE-----EKEVEVAK--LQDEISLQQAELQSL 380
+ E E L+ + T S A E E+EV V K L +E +A++Q +
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 381 REELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIR 440
RQK +A E+ E L K + +L N+ +LE++ + +L +R
Sbjct: 1205 -----RQKHAQAVEELTEQLEQF---------KRAKANLDKNKQTLEKE--NADLAGELR 1248
Query: 441 QKVALTQELEAWQDDMQVVIGQQLRSQ 467
QE+E + ++ + Q+L+S+
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQV-QELQSK 1274
Score = 66.2 bits (160), Expect = 7e-11
Identities = 98/485 (20%), Positives = 203/485 (41%), Gaps = 66/485 (13%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE L QLQ + + A E+ L + +EL L + A+ E E+R QQ E R
Sbjct: 894 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-R 952
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQ- 163
+ +A + + E + E EA R +L ++ + ++ + + +QN +LS++
Sbjct: 953 KKMAQQMLDLEEQLEE----EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 164 ---------LAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQ 214
L E+E + L L+ + ++ +EL RL+ + Q L+ ++
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI---SELEVRLKKEEKSRQELEKLKR 1065
Query: 215 DLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQR 274
LE E++ + ++ +L E + L+ ++ AL +R L+
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 275 RVSELEE------------ESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT- 321
+S+L+E E + +D +L++EL +LD Q A + T
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 322 -----------RSPKTRKASSPQPSPPEEILEPPK--KRTSLSPAEILEEKEVEVAKLQD 368
+ ++ EE+ E + KR + + + E E A L
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 369 EISL---QQAELQSLREELQRQ-KELRAQEDPGEALHSALSDR---------------DE 409
E+ + + E++ +++L+ Q +EL+++ GE + L+D+ +E
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 410 AVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALT---QELEAWQDDMQVVIGQQLRS 466
A KA++L+ + +S + L RQK+ ++ ++LE ++ +Q + +++ +
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 467 QRQKE 471
++ E
Sbjct: 1366 KQNLE 1370
Score = 62.8 bits (151), Expect = 7e-10
Identities = 74/350 (21%), Positives = 161/350 (46%), Gaps = 29/350 (8%)
Query: 135 QRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAE 194
Q + Q++ + + L + E+ + +L + Q +L E + L+ Q QA+ AE
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 195 LRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLE 254
L + Q L+ ++EA+ L EE ++G ++L R++ + L+
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEAR---LEEEEDRG--------QQLQAERKKMAQQMLD 961
Query: 255 LERARSEAGEALSALR----RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQ 310
LE E A L+ + ++ +LE+E + D + S + +L L++
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEERISDL 1018
Query: 311 GADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK-EVEVAKLQDE 369
+ + ++ T+ + + E + K+ S E L+ K E + + ++
Sbjct: 1019 TTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 370 ISLQQAELQSLREEL-QRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLER 428
I+ QA++ L+ +L ++++EL+A L ++ ++ A+ K EL ++ + +
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAAL---ARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 429 DSLSRELLRAIRQKVALTQELEAWQDDMQVVIG-----QQLRSQRQKELS 473
DS +A +QK L +ELEA + +++ + Q+LR++R++E++
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Score = 60.5 bits (145), Expect = 4e-09
Identities = 98/440 (22%), Positives = 184/440 (41%), Gaps = 66/440 (15%)
Query: 76 EELRRQLETLS---AQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQL 132
EEL QLE A + ++ L++EN +L L G + E+E + L AQ+
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ----EVEHKKKKLEAQV 1268
Query: 133 GEQRSEQQDSGRERARA---LSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQ-AQ 188
E +S+ D R RA + +L + ++ L +A +L +++ +L Q Q Q
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 189 ALAGAELR------TRLESLQGENQMLQSR-------RQDLEAQIRGLREEVEKGEGRLQ 235
L E R T+L L+ E LQ + +Q+LE I L ++ + +LQ
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 236 TTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASL 295
+ L ++ E+E + E +A +L++ + L++E L D V +
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE--LDDLVVDLDN- 1445
Query: 296 QSELAHSLDD-------------------GDQGQGADAPGDTPTTRSPKTRKASSPQPSP 336
Q +L +L+ D+ A+A T++ +A
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 337 PEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDP 396
EE LE K +++ K+ +V K E+ + L++ EE++ Q L ED
Sbjct: 1506 KEE-LERTNKMLKAEMEDLVSSKD-DVGKNVHELEKSKRALETQMEEMKTQ--LEELEDE 1561
Query: 397 GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDM 456
+A A LE+++Q + ERD +R+ +++ L ++L ++ ++
Sbjct: 1562 LQATEDA--------KLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETEL 1612
Query: 457 QVVIGQQLRSQRQKELSASA 476
+ ++Q+ L+A+A
Sbjct: 1613 E-------DERKQRALAAAA 1625
Score = 53.5 bits (127), Expect = 4e-07
Identities = 76/296 (25%), Positives = 121/296 (40%), Gaps = 64/296 (21%)
Query: 33 RRDSFLGGGPGPEEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLER 92
R + F ++ + L L Q ++DL A K EEL +L A L
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL----ASSLSG 1730
Query: 93 EERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE 152
LQ E +R L AR A+ E E +G++EA+ +R R ++
Sbjct: 1731 RNALQDE----KRRLEARIAQLEEELEEEQGNMEAMS---------------DRVRKATQ 1771
Query: 153 LSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGE-NQMLQS 211
+EQ LS +LA TE+ ++ ++ R Q + Q ELR++L ++G +S
Sbjct: 1772 QAEQ---LSNELA----TERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKS 1821
Query: 212 RRQDLEAQIRGLREEVEKGEGRLQTT-----------HEELLLLRRERR----------- 249
LEA+I L E+VE+ Q E LL + ER+
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 250 ------EHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSEL 299
+ +LE A E+ + R+LQR + E E + +V+A L+S+L
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA--LKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 79.7 bits (195), Expect = 6e-15
Identities = 95/437 (21%), Positives = 181/437 (41%), Gaps = 43/437 (9%)
Query: 53 QLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGA 112
+LQQ+ DL++ + + L+ E+ +R+ + L A+ E+ + + + R A
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAR 1479
Query: 113 EWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQ 172
E E +A+ L +E E A EL N L ++ ++
Sbjct: 1480 EKETKALSLARALE------------------EALEAKEELERTNKMLKAEMEDLVSSKD 1521
Query: 173 ELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKG-E 231
++ + + L +A E++T+LE L+ E Q + + LE ++ L+ + E+ +
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 232 GRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVS--ELEEESRLQDAD 289
R + E+ L+R+ E+ ELE R + A +A ++L+ + EL+ +S ++ +
Sbjct: 1582 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 290 VSAASLQSELAHSLDDGDQGQGADAPGD------TPTTRSPKTRKASSPQPSPPEEILEP 343
+ L+ A D + + A A D + K+ +A Q E
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 344 PKKRTSLSPAEILEEKEVEVA---KLQDEISLQQAELQSLREELQRQK--------ELRA 392
+K+ L E+ EE ++ LQDE +A + L EEL+ ++ +R
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 393 QEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALT-QELEA 451
E L + L+ K QL R + E S E+ A++ K T LEA
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 452 WQDDMQVVIGQQLRSQR 468
++ + Q+ R ++
Sbjct: 1822 KIAQLEEQVEQEAREKQ 1838
Score = 78.6 bits (192), Expect = 1e-14
Identities = 98/464 (21%), Positives = 195/464 (42%), Gaps = 54/464 (11%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQ---------------- 88
+E + + ++KE L A + LE EEL R + L A+
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 89 HLEREER-LQQENHELRRGLAARGAEWEA---RAVELEGDVEALRAQLGEQRSEQQDSGR 144
LE+ +R L+ + E++ L E +A + LE +++AL+ Q + +
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 145 ERARALS-ELSEQNLRLS---QQLAQASQTEQELQRELDALRGQCQAQALAGAE------ 194
E+ R L +L E L +Q A A+ +++L+ +L L Q + A+ G E
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS-AIKGREEAIKQL 1647
Query: 195 --LRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHS 252
L+ +++ Q E + ++ R ++ A + ++ + E L E+L R R++
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 253 LELERARSEAGEALSA-------LRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDD 305
LE E E +LS RRL+ R+++LEEE L++ + ++ + +
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE--LEEEQGNMEAMSDRVRKATQQ 1765
Query: 306 GDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAK 365
+Q A + ++ R+ Q L + + E ++A+
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 366 LQDEISLQ----QAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVN-KALELSLQ 420
L++++ + QA +SL+++ ++ KE+ Q + + ++ E N + +L Q
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 421 L-------NRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQ 457
L R++ R L REL A A+ +E+ A + ++
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 74.7 bits (182), Expect = 2e-13
Identities = 100/447 (22%), Positives = 196/447 (43%), Gaps = 55/447 (12%)
Query: 52 LQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQH--LEREERLQQENHELRRGLAA 109
LQ+ ++E+++ + + ER ++ +L+ L +H L E+ L QE + L A
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 110 RGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQ 169
E R + ++E + ++ + E++D G++ ++++Q L L +QL +
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 170 TEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQI----RGLRE 225
Q+LQ E + + +L + + +N L R+ LE +I L E
Sbjct: 965 ARQKLQLEKVTAEAKIK-------KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 226 EVEKGEG--RLQTTHE------ELLLLRRERREHSLE--LERARSEAGEALSALRRLQRR 275
E EK + +L+ HE E+ L + E+ LE + +A + + LQ +
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 276 VSELEEESRLQDADVSA--ASLQSELAHSLDDGD-----QGQGADAPGDTPTTRSPKTRK 328
++EL+ + ++ ++ A A L E+A + +G +D D + R+ + +
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 329 ASSPQPSPPE-EILEPPKKRTSLSPAEILE-----EKEVEVAK--LQDEISLQQAELQSL 380
+ E E L+ + T S A E E+EV V K L +E +A++Q +
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 381 REELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIR 440
RQK +A E+ E L K + +L N+ +LE++ + +L +R
Sbjct: 1198 -----RQKHAQAVEELTEQLEQF---------KRAKANLDKNKQTLEKE--NADLAGELR 1241
Query: 441 QKVALTQELEAWQDDMQVVIGQQLRSQ 467
QE+E + ++ + Q+L+S+
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQV-QELQSK 1267
Score = 66.2 bits (160), Expect = 7e-11
Identities = 98/485 (20%), Positives = 203/485 (41%), Gaps = 66/485 (13%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE L QLQ + + A E+ L + +EL L + A+ E E+R QQ E R
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-R 945
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQ- 163
+ +A + + E + E EA R +L ++ + ++ + + +QN +LS++
Sbjct: 946 KKMAQQMLDLEEQLEE----EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 164 ---------LAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQ 214
L E+E + L L+ + ++ +EL RL+ + Q L+ ++
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI---SELEVRLKKEEKSRQELEKLKR 1058
Query: 215 DLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQR 274
LE E++ + ++ +L E + L+ ++ AL +R L+
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 275 RVSELEE------------ESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTT- 321
+S+L+E E + +D +L++EL +LD Q A + T
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 322 -----------RSPKTRKASSPQPSPPEEILEPPK--KRTSLSPAEILEEKEVEVAKLQD 368
+ ++ EE+ E + KR + + + E E A L
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 369 EISL---QQAELQSLREELQRQ-KELRAQEDPGEALHSALSDR---------------DE 409
E+ + + E++ +++L+ Q +EL+++ GE + L+D+ +E
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 410 AVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALT---QELEAWQDDMQVVIGQQLRS 466
A KA++L+ + +S + L RQK+ ++ ++LE ++ +Q + +++ +
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 467 QRQKE 471
++ E
Sbjct: 1359 KQNLE 1363
Score = 62.8 bits (151), Expect = 7e-10
Identities = 74/350 (21%), Positives = 161/350 (46%), Gaps = 29/350 (8%)
Query: 135 QRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAE 194
Q + Q++ + + L + E+ + +L + Q +L E + L+ Q QA+ AE
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 195 LRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLE 254
L + Q L+ ++EA+ L EE ++G ++L R++ + L+
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEAR---LEEEEDRG--------QQLQAERKKMAQQMLD 954
Query: 255 LERARSEAGEALSALR----RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQ 310
LE E A L+ + ++ +LE+E + D + S + +L L++
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEERISDL 1011
Query: 311 GADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK-EVEVAKLQDE 369
+ + ++ T+ + + E + K+ S E L+ K E + + ++
Sbjct: 1012 TTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 370 ISLQQAELQSLREEL-QRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLER 428
I+ QA++ L+ +L ++++EL+A L ++ ++ A+ K EL ++ + +
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAAL---ARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 429 DSLSRELLRAIRQKVALTQELEAWQDDMQVVIG-----QQLRSQRQKELS 473
DS +A +QK L +ELEA + +++ + Q+LR++R++E++
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Score = 60.5 bits (145), Expect = 4e-09
Identities = 98/440 (22%), Positives = 184/440 (41%), Gaps = 66/440 (15%)
Query: 76 EELRRQLETLS---AQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQL 132
EEL QLE A + ++ L++EN +L L G + E+E + L AQ+
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ----EVEHKKKKLEAQV 1261
Query: 133 GEQRSEQQDSGRERARA---LSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQ-AQ 188
E +S+ D R RA + +L + ++ L +A +L +++ +L Q Q Q
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 189 ALAGAELR------TRLESLQGENQMLQSR-------RQDLEAQIRGLREEVEKGEGRLQ 235
L E R T+L L+ E LQ + +Q+LE I L ++ + +LQ
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 236 TTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASL 295
+ L ++ E+E + E +A +L++ + L++E L D V +
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE--LDDLVVDLDN- 1438
Query: 296 QSELAHSLDD-------------------GDQGQGADAPGDTPTTRSPKTRKASSPQPSP 336
Q +L +L+ D+ A+A T++ +A
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 337 PEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDP 396
EE LE K +++ K+ +V K E+ + L++ EE++ Q L ED
Sbjct: 1499 KEE-LERTNKMLKAEMEDLVSSKD-DVGKNVHELEKSKRALETQMEEMKTQ--LEELEDE 1554
Query: 397 GEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDM 456
+A A LE+++Q + ERD +R+ +++ L ++L ++ ++
Sbjct: 1555 LQATEDA--------KLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETEL 1605
Query: 457 QVVIGQQLRSQRQKELSASA 476
+ ++Q+ L+A+A
Sbjct: 1606 E-------DERKQRALAAAA 1618
Score = 53.5 bits (127), Expect = 4e-07
Identities = 76/296 (25%), Positives = 121/296 (40%), Gaps = 64/296 (21%)
Query: 33 RRDSFLGGGPGPEEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLER 92
R + F ++ + L L Q ++DL A K EEL +L A L
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL----ASSLSG 1723
Query: 93 EERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSE 152
LQ E +R L AR A+ E E +G++EA+ +R R ++
Sbjct: 1724 RNALQDE----KRRLEARIAQLEEELEEEQGNMEAMS---------------DRVRKATQ 1764
Query: 153 LSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGE-NQMLQS 211
+EQ LS +LA TE+ ++ ++ R Q + Q ELR++L ++G +S
Sbjct: 1765 QAEQ---LSNELA----TERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKS 1814
Query: 212 RRQDLEAQIRGLREEVEKGEGRLQTT-----------HEELLLLRRERR----------- 249
LEA+I L E+VE+ Q E LL + ER+
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 250 ------EHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSEL 299
+ +LE A E+ + R+LQR + E E + +V+A L+S+L
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA--LKSKL 1928
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 79.3 bits (194), Expect = 7e-15
Identities = 104/457 (22%), Positives = 196/457 (42%), Gaps = 62/457 (13%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
+E DL LQ+Q E D L AE ER E+L + L A+ E ER ++E E+
Sbjct: 885 KEKNDLQLQVQS-EADSLADAE------ERCEQLIKNKIQLEAKIKEVTERAEEEE-EIN 936
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQ---QDSGRERARALSELSEQNLRLS 161
L A+ + E EL+ D++ L L + E+ ++ + ++ L E +LS
Sbjct: 937 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLS 996
Query: 162 QQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIR 221
++ +T Q+ +L A + A +L +++ L+G + + R DLE R
Sbjct: 997 KEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKR 1056
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALR-------RLQR 274
L EG L+ E + + ++++ +LE+ E +S + +LQ+
Sbjct: 1057 KL-------EGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQK 1109
Query: 275 RVSELE-------EESRLQDADVSAASLQ-SELAHSLDD-----GDQGQGADAPGDTPTT 321
++ EL+ EE + A + A Q S+L+ L++ + G A +
Sbjct: 1110 KIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKK 1169
Query: 322 RS---PKTRKASSPQPSPPEEILEPPKKRTSLSPAEI------LEEKEVEVAKLQDEISL 372
R K R+ E ++ +K+ + S AE+ L+ + ++ K + E+ +
Sbjct: 1170 REAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKM 1229
Query: 373 QQAELQSLREELQR-----QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLE 427
+ +L S E + + +K R+ ED L + ++ +N +L+ Q R+ E
Sbjct: 1230 ETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIN---DLTAQRARLQTE 1286
Query: 428 RDSLSREL-------LRAIRQKVALTQELEAWQDDMQ 457
SR+L + R K A TQ++E + ++
Sbjct: 1287 AGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLE 1323
Score = 68.9 bits (167), Expect = 1e-11
Identities = 113/489 (23%), Positives = 204/489 (41%), Gaps = 77/489 (15%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQH---------------- 89
E E+++ +L++ EL K ++LRR LE + QH
Sbjct: 1145 ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMA 1204
Query: 90 --------LER-EERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQ 140
L+R +++L++E EL+ + EA + + +G++E + L +Q SE +
Sbjct: 1205 ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAIS-KAKGNLEKMCRSLEDQVSELK 1263
Query: 141 DSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRL- 199
E+ R +++L+ Q RL + + S+ E + L QA EL+ +L
Sbjct: 1264 TKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLE 1323
Query: 200 ESLQGENQM---LQSRRQDLEAQIRGLREEVEKGEGRLQ----TTHEELLLLRRERREHS 252
E + +N + LQS R D + +R EE ++G+ LQ + E+ R + +
Sbjct: 1324 EETKAKNALAHALQSSRHDCDL-LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1382
Query: 253 LELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAAS-----LQSELAHSLDDGD 307
++ R+E E A ++L +R+ E EE +A ++ LQ+E+ + D +
Sbjct: 1383 IQ----RTE--ELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1436
Query: 308 QGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEV------ 361
+ A A D K + + LE +K + E+ + K V
Sbjct: 1437 RSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLD 1496
Query: 362 -------EVAKLQDEIS----------LQQAELQSLREELQRQK-ELRAQEDPGEALHSA 403
E LQ EIS Q EL+ ++++++++K E++A AL A
Sbjct: 1497 QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQA------ALEEA 1550
Query: 404 LSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQ-KVALTQELEAWQDDMQVVIGQ 462
+ + K L + L+LN+V E D E I Q K T+ +E Q + I
Sbjct: 1551 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRS 1610
Query: 463 QLRSQRQKE 471
+ + R K+
Sbjct: 1611 RNDALRVKK 1619
Score = 50.1 bits (118), Expect = 5e-06
Identities = 67/291 (23%), Positives = 123/291 (42%), Gaps = 62/291 (21%)
Query: 48 EDLALQLQQKEKDL-LLAAELGKM--LLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EDL QL E+ LL AE+ ++ LE+ E R+ E ER + L +N L
Sbjct: 1668 EDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1727
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 164
+LE DV L++++ E E +++ + +A+++ + +
Sbjct: 1728 N-----------TKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAA--------MM 1768
Query: 165 AQASQTEQELQRELDALRGQCQAQALAGAELRTRLE-----SLQGENQMLQSRRQDLEAQ 219
A+ + EQ+ L+ ++ + +L+ RL+ +L+G + +Q LEA+
Sbjct: 1769 AEELKKEQDTSAHLERMKKNLEQTV---KDLQHRLDEAEQLALKGGKKQIQK----LEAR 1821
Query: 220 IRGLREEVE----------KGEGRLQTTHEELLLLRRERREHSLEL-------------- 255
+R L EVE KG + + +EL E R++ L L
Sbjct: 1822 VRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSY 1881
Query: 256 ----ERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHS 302
E A ++ LS R+LQ + E EE + + ++ V+ ++S H+
Sbjct: 1882 KRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHT 1932
Score = 45.8 bits (107), Expect = 9e-05
Identities = 61/337 (18%), Positives = 144/337 (42%), Gaps = 29/337 (8%)
Query: 173 ELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEG 232
E ++E+ ++ + Q A+ + + L+ + L + DL+ Q++ + + E
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906
Query: 233 RLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSA 292
R + + + L + +E + E E + R+L+ SEL+++ + D +++
Sbjct: 907 RCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD--IDDLELTL 964
Query: 293 ASLQSELAHSLDDGDQGQGADAPG-DTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLS 351
A ++ E H+ ++ + + G D + K +KA + L+ + + +
Sbjct: 965 AKVEKE-KHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVN-- 1021
Query: 352 PAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQK-----ELRAQEDPGEALHSALSD 406
IL + + ++ + D++ + + LR +L+R K +L+ ++ + +
Sbjct: 1022 ---ILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ 1078
Query: 407 RDEAV-NKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLR 465
DE + K E+S ++++ + ++ +L + I++ A +EL G+++
Sbjct: 1079 LDEKLEKKEFEISNLISKIE-DEQAVEIQLQKKIKELQARIEEL-----------GEEIE 1126
Query: 466 SQRQKELSASASSSTPRRAAPRFSLRLGPGPAGGFLS 502
++R A S R S RL AGG S
Sbjct: 1127 AERASRAKAEKQRSDLSRELEEISERL--EEAGGATS 1161
Score = 45.8 bits (107), Expect = 9e-05
Identities = 63/266 (23%), Positives = 123/266 (46%), Gaps = 39/266 (14%)
Query: 51 ALQLQQKEKDLLLAAELGKMLLERNEELRRQLETL----SAQHLEREERLQQENH-ELRR 105
AL++++K + +L +M ++ N R E+L + Q + +E +L ++ +
Sbjct: 1614 ALRVKKK-----MEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQE 1668
Query: 106 GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERA-RALSELSEQNLRLSQQL 164
L + A E RA L+ ++E L A L EQ + R+ A + L + SE+ L Q
Sbjct: 1669 DLKEQLAIVERRANLLQAEIEELWATL-----EQTERSRKIAEQELLDASERVQLLHTQN 1723
Query: 165 AQASQTEQELQRELDALRGQCQA--QALAGAELRTR------------LESLQGENQMLQ 210
T+++L+ ++ L+ + + Q AE + + L+ Q + L+
Sbjct: 1724 TSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1783
Query: 211 SRRQDLEAQIRGLREEVEKGEG-RLQTTHEELLLLRRERREHSLELERARSEAGEALSAL 269
+++LE ++ L+ +++ E L+ +++ L RE E+E + EA+ L
Sbjct: 1784 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGL 1843
Query: 270 RRLQRRVSELEEES--------RLQD 287
R+ +RRV EL ++ RLQD
Sbjct: 1844 RKHERRVKELTYQTEEDRKNVLRLQD 1869
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 78.6 bits (192), Expect = 1e-14
Identities = 103/450 (22%), Positives = 187/450 (41%), Gaps = 77/450 (17%)
Query: 69 KMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEAL 128
+ + E E L RQ E + A+ E++L QE +L + + E +L+ V+AL
Sbjct: 1967 QQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKAL 2026
Query: 129 RAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLA--------QASQTEQE---LQRE 177
+ EQ S + +E+ L +L +QN L +QL QA E E Q+E
Sbjct: 2027 EIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQE 2086
Query: 178 LDALRGQCQA----------QALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEV 227
+ L Q + Q +L L+ + L ++ L+ I+ EE+
Sbjct: 2087 IQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEI 2146
Query: 228 EKGEGRLQTTHEELLLLRRE-------RREHSLE--LERARSEAGEALSALRRLQRRVSE 278
EK E R++ + LL+ R+ + E SLE L+ R + L+ ++ +
Sbjct: 2147 EKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQ 2206
Query: 279 LEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPE 338
EE ++ +V +Q E+ TTR + + + E
Sbjct: 2207 FREELENKNEEVQQLHMQLEIQKK---------------ESTTRLQELEQENKLFKDDME 2251
Query: 339 EILEPPKKRTSLSP----------AEILEEKEVEVAKLQDEISLQQAELQ---------- 378
++ K+ ++S A+I++EKEVE+ +L ++++ Q +L+
Sbjct: 2252 KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEE 2311
Query: 379 --SLREELQRQKEL---------RAQEDPGEALHSALSD-RDEAVNKALELSLQLNRVSL 426
L +L+ Q E R +E+ E L+ + + E N + S+ + +S
Sbjct: 2312 KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2371
Query: 427 ERDSLSRELLRAIRQKVALTQELEAWQDDM 456
E DSL +L I +K+AL Q++E ++M
Sbjct: 2372 EADSLKHQLDVVIAEKLALEQQVETANEEM 2401
Score = 56.6 bits (135), Expect = 5e-08
Identities = 87/432 (20%), Positives = 186/432 (43%), Gaps = 59/432 (13%)
Query: 82 LETLSAQHLEREERLQQENHELRRGLAARGA-------EWEARAVELEGDVEALRAQLGE 134
LE + ++ ++ +++ N EL G E+EA + +G + L A L +
Sbjct: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
Query: 135 QRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAE 194
R E+ ++ RE EL+EQ+ +L Q Q Q + L+ + Q A +
Sbjct: 217 ARREKDETMRE----FLELTEQSQKLQIQFQQL-QASETLRNSTHSSTAADLLQ--AKQQ 269
Query: 195 LRTRLESLQGENQML---QSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREH 251
+ T + L+ ++ +L Q +++D QI L+E+++ E E
Sbjct: 270 ILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE-----------------MEQ 312
Query: 252 SLELERA-RSEAGEALSALRRLQRRVSELEEES-RLQDADVSAASLQSELAHSLDDGDQG 309
++E + + E E + + L ++ E E+++ L+D +A L EL + +Q
Sbjct: 313 DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQE 372
Query: 310 QGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDE 369
T + + + Q E L+ + S +I++ E E + ++
Sbjct: 373 IKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQ 432
Query: 370 ISLQQAELQ-----SLREELQRQKELRAQE----DPGEALHSALS--------DRDEAVN 412
+ + E+ +++EL RQ + +E GE ++ S D+ + +N
Sbjct: 433 LRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMN 492
Query: 413 KAL-ELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDM-----QVVIGQQLRS 466
A+ EL+++L + +++ L EL + +K AL ++LE +++ Q+ +Q +
Sbjct: 493 VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIA 552
Query: 467 QRQKELSASASS 478
+++ +L+ + S
Sbjct: 553 EQESKLNEAHKS 564
Score = 51.6 bits (122), Expect = 2e-06
Identities = 90/365 (24%), Positives = 153/365 (41%), Gaps = 74/365 (20%)
Query: 48 EDLALQLQQK-EKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREE----RLQ----- 97
+D A +LQ++ + ++ AEL L + EL TL AQH +E RL+
Sbjct: 3136 KDRATELQEQLSSEKMVVAELKSELAQTKLELET---TLKAQHKHLKELEAFRLEVKDKT 3192
Query: 98 QENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQN 157
E H L LA+ + ++ EL+ +E +A+LG ++ + +L ++N
Sbjct: 3193 DEVHLLNDTLASE----QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN 3248
Query: 158 LRLSQQLAQASQTEQELQRELDALR----GQCQAQALAGAELRTRLESLQGENQMLQS-- 211
L+L+ L Q Q E Q+++++ R Q + EL+ LES + + + S
Sbjct: 3249 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3308
Query: 212 -RRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALR 270
R ++L AQ L+ G+ R E+LL +E +LE S E L+
Sbjct: 3309 DRERELHAQ---LQSSDGTGQSRPPLPSEDLL------KELQKQLEEKHSRIVELLNETE 3359
Query: 271 RLQRRVSELEEESRLQ-DADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKA 329
+ ++ L+ +++ D V +LQ+E Q A+ G +K
Sbjct: 3360 KY--KLDSLQTRQQMEKDRQVHRKTLQTE-----------QEANTEG----------QKK 3396
Query: 330 SSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKE 389
S E++ LEEK +V KL L+ LQ + +E Q+Q E
Sbjct: 3397 MHELQSKVEDLQRQ------------LEEKRQQVYKL----DLEGQRLQGIMQEFQKQ-E 3439
Query: 390 LRAQE 394
L +E
Sbjct: 3440 LEREE 3444
Score = 50.1 bits (118), Expect = 5e-06
Identities = 72/368 (19%), Positives = 157/368 (42%), Gaps = 51/368 (13%)
Query: 121 LEGDVEALRAQLGEQRSEQQDSGRERARALSE-LSEQNLRLSQQLAQASQTEQELQRELD 179
LE +++ ++Q+ E + E S ++RA L E LS + + +++ ++ +QT+ EL+ L
Sbjct: 3114 LEYNIQQKQSQMLEMQVELS-SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3172
Query: 180 ALRGQCQAQALAGAELRTRLESLQGENQML---QSRRQDLEAQIRGLREEVEKGEGRLQT 236
A + E++ + + + N L Q + ++L+ + + ++ + E R +
Sbjct: 3173 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3232
Query: 237 THEELLLLRRERREHSLEL-------ERARSEAGEALSALRRL------QRRVSELEEES 283
E+L +++ +L+L ++ +E+ + + + R L + + LE +
Sbjct: 3233 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3292
Query: 284 RLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEP 343
L+ V + S L + Q Q +D G S P P E++L+
Sbjct: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTG-------------QSRPPLPSEDLLKE 3339
Query: 344 PKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSA 403
+K+ LEEK + +L +E + + R+++++ +++ + L +
Sbjct: 3340 LQKQ--------LEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR-----KTLQTE 3386
Query: 404 LSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQ 463
E K EL ++ + L R+L +Q L E + Q MQ Q+
Sbjct: 3387 QEANTEGQKKMHELQSKV-------EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE 3439
Query: 464 LRSQRQKE 471
L + ++E
Sbjct: 3440 LEREEKRE 3447
Score = 45.4 bits (106), Expect = 1e-04
Identities = 70/350 (20%), Positives = 146/350 (41%), Gaps = 38/350 (10%)
Query: 52 LQLQQKEKDLLLAAELGKMLLE--RNEELRRQLETLSAQHLERE-ERLQQENHELRRGLA 108
++ Q EKD L+ + +++LE + ++L++ L ++ + + LQ+E LR+
Sbjct: 678 IETMQFEKDNLITKQ-NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK 736
Query: 109 ARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQAS 168
+G E EL+ E L Q+ E+ ++ Q+ + S L ++ L L +
Sbjct: 737 EKGT-LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHT 795
Query: 169 QTEQELQRE-LDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEV 227
QE + LD+++ + + + E ++L +DL+ Q L EE+
Sbjct: 796 PVSQEERLIFLDSIKSKSKDSVW------------EKEIEILIEENEDLKQQCIQLNEEI 843
Query: 228 EKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALR-RLQRRVSELEEESRLQ 286
EK + + +E +E L + + + ++ + + ++ L EE LQ
Sbjct: 844 EKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQ 903
Query: 287 DADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPK- 345
+ + ++S + D T +T + E++E +
Sbjct: 904 RINPTTVKMKSSVF----------------DEDKTFVAETLEMGEVVEKDTTELMEKLEV 947
Query: 346 -KRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQE 394
KR L ++ L + ++ + EIS E++SL++E + Q LR +E
Sbjct: 948 TKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE-KEQVSLRCRE 996
Score = 44.3 bits (103), Expect = 3e-04
Identities = 105/516 (20%), Positives = 211/516 (40%), Gaps = 91/516 (17%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNE---ELRRQLETLSAQH----LEREERLQQ 98
E + L Q+ + ++ L + + K++ E+NE +L Q+E L + REE ++Q
Sbjct: 2285 EIDQLNEQVTKLQQQLKITTD-NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343
Query: 99 ENH---ELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQ-------QDSGRERAR 148
N +L++ LA G + A L + ++L+ QL +E+ + + E
Sbjct: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403
Query: 149 ALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQM 208
+ L E N +++ Q +Q L+RE +++ + Q++ + ++ L +
Sbjct: 2404 MKNVLKETNFKMN----QLTQELFSLKRERESVE---KIQSIPENSVNVAIDHLSKDKPE 2456
Query: 209 L-----QSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLEL----ERAR 259
L + + LE Q + E G+G + LL L LEL ++ +
Sbjct: 2457 LEVVLTEDALKSLENQTY-FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIK 2515
Query: 260 SEAGEALSALRRLQRRVSELEE--ESRLQDADVSAASLQS--ELAHSLDDGDQGQGADAP 315
+ LQ+++ L++ E ++ A VS L++ E A D
Sbjct: 2516 DMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPER 2575
Query: 316 GDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAK---LQDEISL 372
+ + + S + I E + + + ILE+++VE+A+ L+ E L
Sbjct: 2576 TNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKL 2635
Query: 373 QQAELQSL---REELQRQKE--------------------------------LRAQEDPG 397
ELQ L E+ QR+KE LRA+
Sbjct: 2636 --LELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2693
Query: 398 EALHSALSDRDEAVNKALELSLQLNRVSLERD-SLSRELLRAIRQKVALTQELEAWQ--- 453
+A ++ ++ E + + L L + N SL++D S R+ L ++K+++ ++ + +
Sbjct: 2694 KAELASYKEKAEKLQEEL-LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2752
Query: 454 -------DDMQVVIGQQLRSQRQKELSASASSSTPR 482
+ + + + + + SQ L S+S+ TP+
Sbjct: 2753 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQ 2788
Score = 42.0 bits (97), Expect = 0.001
Identities = 82/429 (19%), Positives = 174/429 (40%), Gaps = 70/429 (16%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
+E +++ L+L ++ ++E K L+ EEL+++ S + +R++QE
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQET---- 426
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRER--ARALSELSEQNLRLSQ 162
+ +E LRA+L E +Q ++ + ++++ E R
Sbjct: 427 -----------------QRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKG 469
Query: 163 QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRL-------ESLQGENQMLQSRRQD 215
++ A ++ + D Q + +A EL +L E L+ E ++ +
Sbjct: 470 EMENALRSYSNITVNED----QIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCA 525
Query: 216 LEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRR 275
L+ Q+ L EE+ ++Q + + + E L E +SA R+
Sbjct: 526 LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE--SRK 583
Query: 276 VSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPS 335
EL+ E+ + + + L+ E LD + Q A+ + R
Sbjct: 584 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL---------ERLR-------- 626
Query: 336 PPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQ--------QAELQSLREELQRQ 387
++L ++ S ++ E + + KL+D + + Q E+ E +Q +
Sbjct: 627 --TQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFE 684
Query: 388 KE-LRAQEDPGEALHSALSDRDEAV--NKALELSLQLNRVSLERDSLSRELLRAIRQKVA 444
K+ L +++ S L D +++ +K+ E++LQ+N + E + L +E ++K
Sbjct: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE----EKEKGT 740
Query: 445 LTQELEAWQ 453
L QE++ Q
Sbjct: 741 LEQEVQELQ 749
Score = 42.0 bits (97), Expect = 0.001
Identities = 90/419 (21%), Positives = 168/419 (40%), Gaps = 66/419 (15%)
Query: 96 LQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSE 155
+ EN EL +++R L+ VE L + E S+ + + + +EL
Sbjct: 1835 IDPENEELMLNISSR----------LQAAVEKLLEAISETSSQLEHAKVTQ----TELMR 1880
Query: 156 QNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQD 215
++ R Q+ ++ + ++EL+ L + A+ ++ ++ E + + + Q+
Sbjct: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQE 1940
Query: 216 LEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRR 275
I L +E+ RLQ E ++ ER S + E ++EAG L LQ
Sbjct: 1941 KTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQL--LQET 1998
Query: 276 VSELEEESRLQ-DADVSAASLQSEL-AHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQ 333
++E+ +Q A+ LQ ++ A +D +Q T R+ Q
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQ----Q 2054
Query: 334 PSPPEEILEPPKKRTSLSPAEILEEKEV---EVAKLQDEISL----------QQAELQSL 380
E+ LE +K + E++V E+ KL+ ++ + Q E++ L
Sbjct: 2055 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQL 2114
Query: 381 -----------------REELQ-----RQKELRAQEDPGEALHSALSDRDE----AVNKA 414
+E+LQ R +E+ E L AL D AV
Sbjct: 2115 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK 2174
Query: 415 LELSLQLNRVSLERDSLSR---ELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQK 470
ELSL++ ++ ERD++ R E+ Q +ELE +++Q + QL Q+++
Sbjct: 2175 PELSLEV-QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQ-QLHMQLEIQKKE 2231
Score = 42.0 bits (97), Expect = 0.001
Identities = 47/234 (20%), Positives = 92/234 (39%), Gaps = 19/234 (8%)
Query: 72 LERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQ 131
L+R EL QL++ + R + +L + L + E +R VEL + E +
Sbjct: 3308 LDRERELHAQLQSSDGTG---QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLD 3364
Query: 132 LGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALA 191
+ R + + + + L E N +++ + ++LQR+L+ R Q L
Sbjct: 3365 SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE 3424
Query: 192 GAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEV---------------EKGEGRL-Q 235
G L+ ++ Q + + +R+ + L E +K EG +
Sbjct: 3425 GQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKE 3484
Query: 236 TTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDAD 289
+ + +L+ + + ELE R + S L+ L ++ SE + D D
Sbjct: 3485 SNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDED 3538
Score = 30.8 bits (68), Expect = 3.0
Identities = 66/331 (19%), Positives = 140/331 (42%), Gaps = 28/331 (8%)
Query: 80 RQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQ 139
+Q++ + Q E LQ++ L++ + + A ++LE V+ + ++
Sbjct: 2512 KQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA-VQEYAKFCQDNQTIS 2570
Query: 140 QDSGRERARALSELSEQNLR--LSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRT 197
+ R + L++L E L +S + S+ E ++ +L + + +A +
Sbjct: 2571 SEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV-- 2628
Query: 198 RLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGR----LQTTHEELLLLRRERREHSL 253
L+ E ++L+ ++ LE + RE+ +K + L+TT E L E
Sbjct: 2629 ----LEKEKKLLELQKL-LEGNEKKQREKEKKRSPQDVEVLKTTTE--LFHSNEESGFFN 2681
Query: 254 ELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDD-GDQGQGA 312
ELE R+E+ + L + + +L+EE +++ +++ SLQ +L+ D + +
Sbjct: 2682 ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT--SLQKDLSQVRDHLAEAKEKL 2739
Query: 313 DAPGDTPTTRSPKTRKASSPQPSP-------PEEILEPPKKRTSLSPAEILEEKEVEVAK 365
T +++KA +P P + K +S +IL +
Sbjct: 2740 SILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799
Query: 366 LQDEISLQQAE--LQSLREELQRQKELRAQE 394
LQ E S ++ + E++++ +EL A E
Sbjct: 2800 LQSECSSEEVTEIISQFTEKIEKMQELHAAE 2830
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 77.8 bits (190), Expect = 2e-14
Identities = 90/422 (21%), Positives = 182/422 (43%), Gaps = 40/422 (9%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
E +L+ QL++KE + + + ++ EEL+RQLE + LQ H+
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL 1343
Query: 106 GLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLA 165
E E +A EL+ + +++ + R++ + +R EL E +L+Q+L
Sbjct: 1344 LREQYEEEQEGKA-ELQRALSKANSEVAQWRTKYETDAIQRTE---ELEEAKKKLAQRL- 1398
Query: 166 QASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLRE 225
Q+ + +++A+ +C + L+ +E L + + S L+ + R +
Sbjct: 1399 ------QDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDK 1452
Query: 226 EVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRL 285
+ + + + + + EL +E R S EL + ++ EAL L ++R LE+E
Sbjct: 1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQE--- 1509
Query: 286 QDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPK 345
A L ++A + G T K+RK + + + LE +
Sbjct: 1510 ------IADLTEQIAEN-------------GKT-IHELEKSRKQIELEKADIQLALEEAE 1549
Query: 346 KRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALS 405
A+IL ++E+ +++ EI + AE E+L+R + R E AL + +
Sbjct: 1550 AALEHEEAKIL-RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQ-RTVETMQSALDAEVR 1607
Query: 406 DRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLR 465
R+EA+ ++ LN + ++ +R+ ++ ++ +L+ D Q+ + LR
Sbjct: 1608 SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK----DTQLHLDDALR 1663
Query: 466 SQ 467
Q
Sbjct: 1664 GQ 1665
Score = 76.3 bits (186), Expect = 6e-14
Identities = 104/451 (23%), Positives = 189/451 (41%), Gaps = 64/451 (14%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
+E DL LQ+Q + ++LL A E L++ +L +++ ++ ER + E E+
Sbjct: 883 QEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVT-------ERAEDEE-EIN 934
Query: 105 RGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQ---QDSGRERARALSELSEQNLRLS 161
L A+ + E EL+ D++ L L + E+ ++ + LS L E +L+
Sbjct: 935 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLT 994
Query: 162 QQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIR 221
++ + Q+ +L A + + ++L ++E L+ + + R DLE R
Sbjct: 995 REKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKR 1054
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALS-------------- 267
L EG L+ E +L L ++++ L++ E + S
Sbjct: 1055 KL-------EGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQK 1107
Query: 268 ALRRLQRRVSELEEESRLQDADVSAASLQ-SELAHSLDDGDQGQGADAPGDTPT------ 320
++ LQ R+ ELEEE + A + Q S+ A L++ + + +A G T T
Sbjct: 1108 KIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSE-RLEEAGGVTSTQIELNK 1166
Query: 321 ---TRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEI------LEEKEVEVAKLQDEIS 371
K R+ E ++ +K+ + S AE+ L+ + ++ K + E
Sbjct: 1167 KREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1226
Query: 372 LQQAELQSLREELQR-----QKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSL 426
L+ +L S E + + +K R ED L A +E EL+ Q +R+
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKICRTLED---QLSEARGKNEEIQRSLSELTTQKSRLQT 1283
Query: 427 ERDSLSREL-------LRAIRQKVALTQELE 450
E LSR+L + R K A TQ+ E
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTE 1314
Score = 65.1 bits (157), Expect = 1e-10
Identities = 116/518 (22%), Positives = 198/518 (38%), Gaps = 95/518 (18%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELR-----------RQLETLSAQ----- 88
E+ + L LQ Q+K K+L E + +E R R+LE LS +
Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG 1155
Query: 89 -----HLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSG 143
+E ++ + E +LRR L + EA L A+LGEQ Q
Sbjct: 1156 GVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVK 1215
Query: 144 RERARALSEL----------------SEQNLR-----LSQQLAQASQTEQELQRELDALR 182
++ + SE S+ NL L QL++A +E+QR L L
Sbjct: 1216 QKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELT 1275
Query: 183 GQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGE-------GRLQ 235
Q EL +LE + L +Q Q L+ ++E+ LQ
Sbjct: 1276 TQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQ 1335
Query: 236 TTHEELLLLR---RERREHSLELERARSEAGEALSALRRLQ-----RRVSELEE-----E 282
++ + LLR E +E EL+RA S+A ++ R +R ELEE
Sbjct: 1336 SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1395
Query: 283 SRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILE 342
RLQD++ ++ ++ A + QG R+ A + +++L
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 1455
Query: 343 PPKKRTSLSPAEI---LEEK---EVEVAKLQ-------DEISLQQAELQSLREELQRQKE 389
K + S AE+ L+E E+ KL+ D++ + E ++L +E+ E
Sbjct: 1456 EWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTE 1515
Query: 390 LRAQEDPGEALHSALSDRDEAVNKALELSLQLN--------------RVSLERDSLSREL 435
A+ G+ +H R + + ++ L L R+ LE + E+
Sbjct: 1516 QIAEN--GKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEI 1573
Query: 436 LRAIRQK----VALTQELEAWQDDMQVVIGQQLRSQRQ 469
R I +K L + + + MQ + ++RS+ +
Sbjct: 1574 DRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNE 1611
Score = 54.3 bits (129), Expect = 3e-07
Identities = 67/264 (25%), Positives = 124/264 (46%), Gaps = 35/264 (13%)
Query: 51 ALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAAR 110
A++L++K + +L ++ ++ + R+ ETL +HL R + Q ++ +L A R
Sbjct: 1612 AIRLKKK-----MEGDLNEIEIQLSHANRQAAETL--KHL-RSVQGQLKDTQLHLDDALR 1663
Query: 111 GAE-WEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLR---LSQQLAQ 166
G E + + +E L+A++ E R+ + + R R A EL + N R L Q
Sbjct: 1664 GQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTS 1723
Query: 167 ASQTEQELQREL--------DALRGQCQAQALA------GAELRTRLESLQGENQMLQSR 212
T+++L+ +L DA R A+ A A + L+ Q + L+
Sbjct: 1724 LIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1783
Query: 213 RQDLEAQIRGLREEVEKGEG-RLQTTHEELLLLRRERREHSLELERARSEAGEALSALRR 271
+++LE ++ L+ +++ E L+ +++ L RE ELE + + E++ LR+
Sbjct: 1784 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRK 1843
Query: 272 LQRRVSELEEES--------RLQD 287
+RRV EL +S RLQD
Sbjct: 1844 YERRVKELTYQSEEDRKNVLRLQD 1867
Score = 52.4 bits (124), Expect = 1e-06
Identities = 82/392 (20%), Positives = 158/392 (40%), Gaps = 42/392 (10%)
Query: 102 ELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLS 161
E + +A E++ EL EA R +L E+ + + SE L
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKS-EAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 162 QQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIR 221
++ Q + + +L+ ++ + + + + AEL + L+ E L+ DLE +
Sbjct: 904 ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 963
Query: 222 GLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEE 281
+ +E E +++ EEL L + + E + + +AL L+ + +V+ L +
Sbjct: 964 KVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNK 1023
Query: 282 -ESRL-QDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEE 339
+S+L Q + +SL+ E +D RK E
Sbjct: 1024 TKSKLEQQVEDLESSLEQEKKLRVD-----------------LERNKRKLEGDLKLAQES 1066
Query: 340 ILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQ--------------QAELQSLREELQ 385
IL+ + L E L++K+ E +LQ ++ + QA ++ L EE++
Sbjct: 1067 ILDLENDKQQLD--ERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124
Query: 386 RQKELRAQEDPGEALHS----ALSDRDEAVNKALELSLQLNRV-SLERDSLSRELLRAIR 440
++ RA+ + + ++ LS+R E ++LN+ E L R+L A
Sbjct: 1125 AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATL 1184
Query: 441 QKVALTQELEAWQDDMQVVIGQQLRS-QRQKE 471
Q A+ L D +G+Q+ + QR K+
Sbjct: 1185 QHEAMVAALRKKHADSVAELGEQIDNLQRVKQ 1216
Score = 42.0 bits (97), Expect = 0.001
Identities = 68/370 (18%), Positives = 145/370 (39%), Gaps = 59/370 (15%)
Query: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEE--LRRQLETLSAQHLEREERLQQENHEL 103
E E Q++ ++ D+ LA E + LE E LR QLE L Q E+
Sbjct: 1526 ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE------------LTQVKSEI 1573
Query: 104 RRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQ 163
R +A + E E + VE +++ L + + ++ R + + +L+E ++LS
Sbjct: 1574 DRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHA 1633
Query: 164 LAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQD-------- 215
QA++T + L S+QG+ + Q D
Sbjct: 1634 NRQAAETLKHL-------------------------RSVQGQLKDTQLHLDDALRGQEDL 1668
Query: 216 ------LEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSAL 269
+E + L+ EVE+ L+ T L +E + + ++ ++ +
Sbjct: 1669 KEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTK 1728
Query: 270 RRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKA 329
++L+ + +L+ E ++DA A + + + ++ D + + +K
Sbjct: 1729 KKLETDLMQLQSE--VEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1786
Query: 330 SSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAE----LQSLREELQ 385
+ L+ ++ + +++ E + +L+ E+ +Q + ++ LR+ +
Sbjct: 1787 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYER 1846
Query: 386 RQKELRAQED 395
R KEL Q +
Sbjct: 1847 RVKELTYQSE 1856
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 77.8 bits (190), Expect = 2e-14
Identities = 111/496 (22%), Positives = 217/496 (43%), Gaps = 70/496 (14%)
Query: 46 EPEDLALQLQQKEKDLLLAAELG---------KMLLERNEELRRQLE--TLSAQHLER-E 93
E + LALQ Q + + +LG K LL+ E L ++LE L+ LE+ +
Sbjct: 1363 EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTK 1422
Query: 94 ERLQQENHEL------RRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRER- 146
RLQQE +L +R +A+ + + + +L + +++ A+ E+R + RE+
Sbjct: 1423 NRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKE 1482
Query: 147 ------ARALSELSE-------QNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGA 193
ARAL E E QN +L + ++ ++ + + L +A
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVE 1542
Query: 194 ELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKG-EGRLQTTHEELLLLRRERREHS 252
E+RT+LE L+ E Q + + LE ++ ++ + E+ + R + E+ LL ++ RE
Sbjct: 1543 EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELE 1602
Query: 253 LELERARSEAGEALSALRRLQRRVSELEE--ESRLQDADVSAASLQSELAHSLDDGDQGQ 310
ELE R + A+++ ++++ + +LE E+ + D L+ A D + +
Sbjct: 1603 AELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662
Query: 311 GADAPGDTPTTRSPKTRKASSPQPSP----PEEILEPPKKR----------------TSL 350
A A D +S ++ K + EE+ + R ++
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSAS 1722
Query: 351 SPAEILEEK---EVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDR 407
+ +L+EK E +A+L++E+ +Q+ ++ L + R+ L+ + L++ L+
Sbjct: 1723 GKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF-RKTTLQV-----DTLNAELAAE 1776
Query: 408 DEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQ 467
A K+ QL R + E + +EL A++ K +A ++ IGQ
Sbjct: 1777 RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK------FKATISALEAKIGQLEEQL 1830
Query: 468 RQKELSASASSSTPRR 483
Q+ +A++ RR
Sbjct: 1831 EQEAKERAAANKLVRR 1846
Score = 73.6 bits (179), Expect = 4e-13
Identities = 101/455 (22%), Positives = 204/455 (44%), Gaps = 46/455 (10%)
Query: 45 EEPEDLALQLQQKEKDLLLAAE-LGKML--LERNEE-LRRQLETLSAQHLEREERLQQ-E 99
EE E QL+ +DL+ + + +GK + LE+++ L +Q+E + Q E E+ LQ E
Sbjct: 1500 EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE 1559
Query: 100 NHELRR--GLAARGAEWE----ARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSEL 153
+ +LR + A A++E R + E L Q+ E +E +D ++RA A++
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASK 1619
Query: 154 SEQNLRLSQ---QLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQ 210
+ + L Q+ A++ E+ ++L L+ Q + E R + + +++ +
Sbjct: 1620 KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESE 1679
Query: 211 SRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALR 270
+ + LEA+I L+EE+ E + H E +ER E + E+ + S L R
Sbjct: 1680 KKLKSLEAEILQLQEELASSERARR--HAE-----QERDELADEITNSASGKSALLDEKR 1732
Query: 271 RLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 330
RL+ R+++LEEE L+ E ++ D+ + DT R A+
Sbjct: 1733 RLEARIAQLEEE------------LEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780
Query: 331 SPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKEL 390
+ +++ +++ A++ E + +K + IS +A++ L E+L+++ +
Sbjct: 1781 QKSDNARQQL----ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836
Query: 391 RAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELE 450
RA + L R E K E+ +Q+ D ++ +A + L ++LE
Sbjct: 1837 RAAA-------NKLVRRTE--KKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE 1887
Query: 451 AWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAA 485
+++ + + QR+ + + A+ R +
Sbjct: 1888 EAEEEATRANASRRKLQRELDDATEANEGLSREVS 1922
Score = 72.8 bits (177), Expect = 7e-13
Identities = 106/480 (22%), Positives = 212/480 (44%), Gaps = 65/480 (13%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR 104
EE LA QLQ + + A E+ L + +EL L L ++ E EER Q +E +
Sbjct: 887 EEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNE-K 945
Query: 105 RGLAARGAEWEARAVELEG-----DVEALRAQLGEQRSEQ-----QDSGRERARALSELS 154
+ + A + E + E EG +E + A+ ++ E+ +D + + +
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Query: 155 EQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQ 214
++ S QLA+ E+E + L +R + Q + ++L RL+ + Q L+ ++
Sbjct: 1006 DRIAECSSQLAE----EEEKAKNLAKIRNK---QEVMISDLEERLKKEEKTRQELEKAKR 1058
Query: 215 DLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSE-----AGEALSAL 269
L+ + L++++ LQ +E L L+ ++E L+ AR + AL +
Sbjct: 1059 KLDGETTDLQDQI----AELQAQIDE-LKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 270 RRLQRRVSELEE------------ESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGD 317
R LQ +++EL+E E + +D +L++EL +LD Q +
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE 1173
Query: 318 TPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEI-------------LEEKEVEVA 364
+ +KA + E ++ ++R + + E+ LE+ + +
Sbjct: 1174 QEVA---ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
Query: 365 KLQDEISLQQAELQSLREELQ-RQKELRAQEDPGEALHSALSDRD----EAVNKALELSL 419
E++ + LQ ++ E + ++K+L AQ + LH+ +S+ D E KA +L
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQV---QELHAKVSEGDRLRVELAEKASKLQN 1287
Query: 420 QLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLR-SQRQKELSASASS 478
+L+ VS + ++ ++ + +L +L+ Q+ +Q Q+L S R ++L +S
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Score = 68.2 bits (165), Expect = 2e-11
Identities = 91/440 (20%), Positives = 185/440 (42%), Gaps = 42/440 (9%)
Query: 52 LQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARG 111
LQ+ ++E++L E + E+ ++ +LE + +H ++L +E + L L A
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKH----QQLLEEKNILAEQLQAE- 899
Query: 112 AEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTE 171
EL + E +RA+L ++ E ++ + + E E+N L + +
Sbjct: 900 -------TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952
Query: 172 QELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGE 231
Q+L+ +LD G Q L +++ ++ E +L+ + + + + + + +
Sbjct: 953 QDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 232 GRLQTTHEELLLLRRERREHSL-------ELERARSEAGEALSALRRLQRRVSELEEESR 284
+L E+ L + R + + L++ E A R+L ++L+++
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072
Query: 285 LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEP- 343
A + LQ LA ++ QGA A GD T K + E+ E
Sbjct: 1073 ELQAQIDELKLQ--LAKK---EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDF 1127
Query: 344 PKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEA-LHS 402
++ S + A E + L +E+ + EL+ + Q+ELR + + A L
Sbjct: 1128 ESEKASRNKA------EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 403 ALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDD-----MQ 457
AL +E N ++ R + + LS +L +A R K L + + + D +
Sbjct: 1182 AL--EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Query: 458 VVIGQQLRSQ---RQKELSA 474
V + QQ++++ ++K+L A
Sbjct: 1240 VKVLQQVKAESEHKRKKLDA 1259
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 77.4 bits (189), Expect = 3e-14
Identities = 82/429 (19%), Positives = 191/429 (44%), Gaps = 24/429 (5%)
Query: 57 KEKDLLLAAELGKMLLERNE------ELRRQLETLSAQHLEREERLQQENHELRRGLAAR 110
KEK+ L EL + E++E EL+R+LET L +E +++++ ++R +
Sbjct: 10 KEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIP-LPQEGQVREQEGQVREQ-EGQ 67
Query: 111 GAEWEARAVELEGDVEALRAQLGEQRS---EQQDSGRERARALSELSEQNLRLSQQLAQA 167
E E + E EG V Q+ EQ EQ+ RE+ ++ EQ ++ +Q Q
Sbjct: 68 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE---GQVREQEGQVREQEGQV 124
Query: 168 SQTEQELQRELDALR---GQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLR 224
+ E +++ + +R GQ + Q E ++ +G+ + + + ++ E Q+R
Sbjct: 125 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 184
Query: 225 EEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESR 284
+V + EG++ ++ + E ++++ + GE +R+ + ++ E EE+ +
Sbjct: 185 GQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQ 244
Query: 285 LQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPP 344
Q+ V Q E ++ + Q K + Q EE +
Sbjct: 245 KQEEQVQK---QEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQ 301
Query: 345 KKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKE--LRAQEDPGEALHS 402
+++ E + E+E ++ + ++++ Q+ ++ +E++ QKE + +E GE
Sbjct: 302 EEQMR-EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQ 360
Query: 403 ALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQ 462
++ + ++ Q ++ + + + ++ + QK + ++ E + + + +G+
Sbjct: 361 MQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR-EQEEQMGE 419
Query: 463 QLRSQRQKE 471
Q R++E
Sbjct: 420 QKEQMRKQE 428
Score = 60.5 bits (145), Expect = 4e-09
Identities = 61/326 (18%), Positives = 136/326 (41%), Gaps = 18/326 (5%)
Query: 152 ELSEQNLRLSQQLAQASQTEQELQRELDALR-------------GQCQAQALAGAELRTR 198
EL E+N L ++L + E+Q + L+ GQ + Q E +
Sbjct: 8 ELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQ 67
Query: 199 LESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERA 258
+ +G+ + + + ++ E Q+R +V + EG+++ ++ + RE ++
Sbjct: 68 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 127
Query: 259 RSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDT 318
+ E +R + +V E E + R Q+ V Q +GQ + G
Sbjct: 128 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ- 186
Query: 319 PTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQ 378
R + + +E ++ E + E+E ++ K ++++ Q+ ++Q
Sbjct: 187 --VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQ 244
Query: 379 SLREELQRQKE-LRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLR 437
E++Q+Q+E +R QE+ + +++E + K E + Q + E++ RE
Sbjct: 245 KQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTG-EQEEQMREQEE 303
Query: 438 AIRQKVALTQELEAWQDDMQVVIGQQ 463
+R++ +E E + + +G+Q
Sbjct: 304 QMREQEEQMREQEEQMREQEEQMGKQ 329
Score = 58.2 bits (139), Expect = 2e-08
Identities = 54/314 (17%), Positives = 138/314 (43%), Gaps = 25/314 (7%)
Query: 77 ELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQR 136
E Q+ Q E+E +++++ ++R + E E + E EG + Q+GEQ
Sbjct: 147 EQEGQVREQEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQMGEQEGQMGEQE 205
Query: 137 SEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELR 196
+ + + + ++ EQ ++ +Q Q + E+++Q++ + ++ Q + ++R
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR 265
Query: 197 TRLESL-QGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLEL 255
+ E + + E QML+ + Q + + G +EE +++ E++ + RE ++
Sbjct: 266 EQEEQMREQEEQMLKQKEQTEQEEQTGEQEE------QMREQEEQMREQEEQMREQEEQM 319
Query: 256 ERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAP 315
+ G+ + + ++ E +E+ Q+ + G+Q +
Sbjct: 320 REQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM---------------GEQEEQMQKQ 364
Query: 316 GDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQA 375
+ + + RK Q EE + +++ ++ E+KE ++ + ++++ Q+
Sbjct: 365 EEQVRKQEEQMRK-QEEQMRKQEEQMRKQEEQMGEQKEQMGEQKE-QMREQEEQMGEQKE 422
Query: 376 ELQSLREELQRQKE 389
+++ E + QKE
Sbjct: 423 QMRKQEEHMGEQKE 436
Score = 57.8 bits (138), Expect = 2e-08
Identities = 53/247 (21%), Positives = 116/247 (46%), Gaps = 25/247 (10%)
Query: 45 EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLE---REERLQQENH 101
E+ E + Q +Q +K + + E+ E++R+Q E + Q + +EE++Q++
Sbjct: 203 EQEEQMGEQEEQMQKQ-------EEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEE 255
Query: 102 ELRRGLAA-RGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRL 160
++R+ R E + R E + + + + EQ EQ++ RE+ + E EQ +
Sbjct: 256 QMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQ---M 312
Query: 161 SQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQI 220
+Q Q + E+++ ++ + + Q + Q E + E GE + + Q E Q+
Sbjct: 313 REQEEQMREQEEQMGKQEEQMWEQ-KEQMWEQKEQMWKQEEQMGEQ---EEQMQKQEEQV 368
Query: 221 RGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELE 280
R E++ K E +++ E++ R+ ++ + + GE +R + ++ E +
Sbjct: 369 RKQEEQMRKQEEQMRKQEEQM-------RKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421
Query: 281 EESRLQD 287
E+ R Q+
Sbjct: 422 EQMRKQE 428
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 76.6 bits (187), Expect = 5e-14
Identities = 127/552 (23%), Positives = 220/552 (39%), Gaps = 123/552 (22%)
Query: 39 GGGPGPEEPEDLALQLQQ--KEKDLLLAAELG--KMLLERNEELRRQLETL--------- 85
G G + E+L +L + K++ L +++G + L E+ EE R E L
Sbjct: 360 GQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQ 419
Query: 86 SAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQL------------- 132
S + L+ +RL + +LR GL + E + + ++G A L
Sbjct: 420 SNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEV 479
Query: 133 --GEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQAL 190
G+QR E+Q RER EL+ L +++A Q E++ +R Q Q
Sbjct: 480 LEGKQRVEEQLRLRER-----ELTALKGALKEEVASRDQ-------EVEHVRQQYQRDT- 526
Query: 191 AGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVE--------------KGEGRLQT 236
+LR ++ ++ +L++ RQ + A +RGL+ E+E K + L+
Sbjct: 527 --EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRA 584
Query: 237 THEELLLLRRERREH-----------SLELERARSEAGEALSA------LRRLQRRVSEL 279
T +ELL LR E+ E ELE+AR+ AG+ L R Q + EL
Sbjct: 585 TKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKEL 644
Query: 280 EEESRLQDA--------------------------DVSAASLQSELAHSLDDGDQGQGAD 313
+ E + Q+ + LQ L D ++ A
Sbjct: 645 QAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAK 704
Query: 314 APGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEK------EVEVAKLQ 367
+ T + R A +E + ++R ++ E + E A+L+
Sbjct: 705 MVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLR 764
Query: 368 DEISLQQAELQSLREELQ-RQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSL 426
D++ +AE Q L E L Q+E + AL + L + + + + LNR +L
Sbjct: 765 DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNR-AL 823
Query: 427 ERDSLSRELLRAIRQKV------------ALTQELEAWQDDMQVVIGQQLRSQRQ--KEL 472
E + RE+LR + ++ L +ELE +D + + QQL++Q + KE
Sbjct: 824 EEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQAL-QQLQAQLEDYKEK 882
Query: 473 SASASSSTPRRA 484
+ + R+A
Sbjct: 883 ARREVADAQRQA 894
Score = 75.5 bits (184), Expect = 1e-13
Identities = 114/454 (25%), Positives = 174/454 (38%), Gaps = 81/454 (17%)
Query: 70 MLLERNEELR---RQLETLSAQHLEREERLQQENHELRRGLA-ARGAEWEARAVELEGDV 125
M + E+LR ++L L + E EE L ++ L+R L AR + + R VE+
Sbjct: 574 MFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKK- 632
Query: 126 EALRAQ-----LGEQRSEQQDSGRERARALS--------------ELSEQNLRLSQQLAQ 166
E LR Q L +R Q+ +GR R R L EL EQNL+L + L Q
Sbjct: 633 ELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQ 692
Query: 167 ASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREE 226
Q +E + + A + T L Q EN + R LE Q++ R
Sbjct: 693 LRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL 752
Query: 227 VEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRV---------- 276
V+ GE ++L L E+++ L ++ E G +A R L+ R+
Sbjct: 753 VDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARL 812
Query: 277 -------------------------SELEEESRLQDADVSAASLQSELAHSLDDGDQGQG 311
+ELEE+ RL D V L EL +D Q
Sbjct: 813 GQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVD--RLNKELEKIGEDSKQAL- 869
Query: 312 ADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLS----------PAEILEEKEV 361
+ R+ + Q + E K LS A + E
Sbjct: 870 QQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAER 929
Query: 362 EVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNK-ALELSLQ 420
+ A+L E+ Q+ LQ L +E + +K R+Q+D L +E V++ EL +
Sbjct: 930 DTARLDKELLAQR--LQGLEQEAENKK--RSQDDRARQLKGL----EEKVSRLETELDEE 981
Query: 421 LNRVSLERDSLSRELLRAIRQKVALTQELEAWQD 454
N V L D ++R + + + L QE A QD
Sbjct: 982 KNTVELLTDRVNRGRDQVDQLRTELMQERSARQD 1015
Score = 57.4 bits (137), Expect = 3e-08
Identities = 92/420 (21%), Positives = 167/420 (39%), Gaps = 71/420 (16%)
Query: 51 ALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHE---LRRGL 107
AL Q+E+ L AA+ + L R EE +R L L + L++E + LRRG
Sbjct: 780 ALNASQEEEGSLAAAK--RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGK 837
Query: 108 AAR--------------GAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSEL 153
A E E + + ++ L+AQL + + + + + R +
Sbjct: 838 AELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDW 897
Query: 154 SEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRR 213
+ + + S L++ Q L++ L A + + L L RL+ L+ E + + +
Sbjct: 898 ASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQ 957
Query: 214 QDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQ 273
D Q++GL E+V + E L + LL + + R R + Q
Sbjct: 958 DDRARQLKGLEEKVSRLETELDEEKNTVELL-------TDRVNRGRDQVD---------Q 1001
Query: 274 RRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQ 333
R ++E S QD + SL+ + + KTR ASS
Sbjct: 1002 LRTELMQERSARQDLECDKISLERQ----------------------NKDLKTRLASSEG 1039
Query: 334 PSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQ-KELRA 392
P S S +++ + ++ +LQ E ++ LQS +L+R+ KEL
Sbjct: 1040 FQKP-----------SASLSQLESQNQLLQERLQAE-EREKTVLQSTNRKLERKVKELSI 1087
Query: 393 QEDPGEALHSALSDRDEAVNKALELSLQLNRVSLER-DSLSRELLRAIRQKVALTQELEA 451
Q + + D+ KAL+ + +ER D L ++ R + ++ + ++L+A
Sbjct: 1088 QIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQA 1147
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,101,540
Number of Sequences: 37866
Number of extensions: 1059698
Number of successful extensions: 17329
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 499
Number of HSP's successfully gapped in prelim test: 1253
Number of HSP's that attempted gapping in prelim test: 7873
Number of HSP's gapped (non-prelim): 5564
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.