Search of human proteins with 11038659

Search of human proteins with 11038659

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11038659 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 2 [Homo sapiens]
         (566 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot...  1178   0.0  
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo...  1127   0.0  
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot...   675   0.0  
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo...   639   0.0  
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot...   628   e-180
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot...   249   4e-66
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot...   239   5e-63
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo...   238   1e-62
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot...   236   3e-62
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot...   231   1e-60
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot...   222   8e-58
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t...   206   6e-53
gi|124430557 a disintegrin-like and metalloprotease with thrombo...   205   8e-53
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot...   201   2e-51
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo...   200   3e-51
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo...   185   1e-46
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo...   184   2e-46
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot...   175   1e-43
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo...   166   4e-41
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo...   155   9e-38
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot...   140   2e-33
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot...   140   2e-33
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot...   125   1e-28
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   107   3e-23
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...    96   7e-20
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot...    82   2e-15
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...    82   2e-15
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...    79   1e-14
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...    79   1e-14
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...    78   2e-14

>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
           2 isoform 2 [Homo sapiens]
          Length = 566

 Score = 1178 bits (3047), Expect = 0.0
 Identities = 566/566 (100%), Positives = 566/566 (100%)

Query: 1   MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV 60
           MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV
Sbjct: 1   MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV 60

Query: 61  PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120
           PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL
Sbjct: 61  PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120

Query: 121 HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG 180
           HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG
Sbjct: 121 HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG 180

Query: 181 LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS 240
           LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS
Sbjct: 181 LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS 240

Query: 241 RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300
           RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE
Sbjct: 241 RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300

Query: 301 IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH 360
           IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH
Sbjct: 301 IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH 360

Query: 361 DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 420
           DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG
Sbjct: 361 DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 420

Query: 421 QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ 480
           QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ
Sbjct: 421 QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ 480

Query: 481 LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA 540
           LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA
Sbjct: 481 LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA 540

Query: 541 PGKFRPGAVAHACYPSTLGGQGRWIA 566
           PGKFRPGAVAHACYPSTLGGQGRWIA
Sbjct: 541 PGKFRPGAVAHACYPSTLGGQGRWIA 566


>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
           motif, 2 isoform 1 preproprotein [Homo sapiens]
          Length = 1211

 Score = 1127 bits (2916), Expect = 0.0
 Identities = 543/543 (100%), Positives = 543/543 (100%)

Query: 1   MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV 60
           MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV
Sbjct: 1   MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV 60

Query: 61  PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120
           PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL
Sbjct: 61  PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120

Query: 121 HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG 180
           HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG
Sbjct: 121 HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG 180

Query: 181 LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS 240
           LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS
Sbjct: 181 LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS 240

Query: 241 RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300
           RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE
Sbjct: 241 RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300

Query: 301 IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH 360
           IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH
Sbjct: 301 IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH 360

Query: 361 DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 420
           DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG
Sbjct: 361 DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 420

Query: 421 QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ 480
           QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ
Sbjct: 421 QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ 480

Query: 481 LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA 540
           LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA
Sbjct: 481 LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA 540

Query: 541 PGK 543
           PGK
Sbjct: 541 PGK 543


>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
           3 proprotein [Homo sapiens]
          Length = 1205

 Score =  675 bits (1741), Expect = 0.0
 Identities = 332/518 (64%), Positives = 387/518 (74%), Gaps = 40/518 (7%)

Query: 49  PLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSH 108
           P+    E  L  PV T+ +GR +SH +SA+  +   R   + P                 
Sbjct: 35  PIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNP---------------EQ 79

Query: 109 LFYNVTVFGRDLHLRLRPNARLVAPGATMEW-----------------QGEKGTTRV--- 148
           LF+N+T FG+D HLRL+PN +LVAPGA +EW                 Q    T R+   
Sbjct: 80  LFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKT 139

Query: 149 EPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRV 208
           EPL  +C YVGD+  +   +SVA+SNCDGLAG+I+ + EE+FIEPLE+G   +E E+GR+
Sbjct: 140 EPLQTNCAYVGDIVDIP-GTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEE-EKGRI 197

Query: 209 HVVYRRPPTSP-PLGGPQALDTGAS-LDSLDSLSRALGVLEEHANSSRRRARRHAADDDY 266
           HVVY+R      P+   +      S L+ LD L    G + +  N + RR RRHA ++DY
Sbjct: 198 HVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRR-RRHAGENDY 256

Query: 267 NIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKS 326
           NIEVLLGVDDSVV+FHGKEHVQ YLLTLMNIVNEIYHDESLG HINVVLVR+I+L Y KS
Sbjct: 257 NIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKS 316

Query: 327 MSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMC 386
           +SLIE GNPS+SLENVCRWA  QQ+ D  H E+HDHAIFLTRQDFGP+GMQGYAPVTGMC
Sbjct: 317 ISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMC 376

Query: 387 HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRF 446
           HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDE  +GS+MAPLVQAAFHR+
Sbjct: 377 HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRY 436

Query: 447 HWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAF 506
           HWSRCS QEL RY+HSYDCLLDDPF HDWP LP+LPG++YSM+EQCRFDFG+GY MCTAF
Sbjct: 437 HWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAF 496

Query: 507 RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKF 544
           RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGT CA GK+
Sbjct: 497 RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKW 534


>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
           motif, 14 isoform 1 preproprotein [Homo sapiens]
          Length = 1226

 Score =  639 bits (1649), Expect = 0.0
 Identities = 330/550 (60%), Positives = 385/550 (70%), Gaps = 23/550 (4%)

Query: 34  PANARLAAAADPPGGPL---GHGAERILAVPVRTDAQGRLVSHVVSA-ATSRAGVRARRA 89
           P +  L AAA      L   G  ++  + VP  TD +GR +SHVVS  A + AG      
Sbjct: 13  PLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDT 72

Query: 90  APV-----------RTPSFPGGN--EEEPGSH-LFYNVTVFGRDLHLRLRPNARLVAPGA 135
            P            R+P  PGG       G H L++NVTVFG++LHLRLRPN RLV PG+
Sbjct: 73  PPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGS 132

Query: 136 TMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLE 195
           ++EWQ +      +PL   C+Y G V G+  A+ VA+SNCDGLAGLIR +  +FFIEPLE
Sbjct: 133 SVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLE 191

Query: 196 KGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR 255
           +G   +EA  GR HVVYRR         P   D       L  L   LG++ +    + R
Sbjct: 192 RGQQEKEAS-GRTHVVYRREAVQQEWAEPDG-DLHNEAFGLGDLPNLLGLVGDQLGDTER 249

Query: 256 RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVL 315
           + RRHA    Y+IEVLL VDDSVV+FHGKEHVQ Y+LTLMNIV+EIYHDESLG HIN+ L
Sbjct: 250 K-RRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308

Query: 316 VRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSG 375
           VR+I++ Y +S+SLIE GNPS+SLE VCRWA+ QQ+ D  H E+HDH +FLTRQDFGPSG
Sbjct: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSG 368

Query: 376 MQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIM 435
           MQGYAPVTGMCHP+RSC LNHEDGFSSAFV+AHETGHVLGMEHDGQGN C DE  LGS+M
Sbjct: 369 MQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVM 428

Query: 436 APLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFD 495
           APLVQAAFHRFHWSRCS+ ELSRYL SYDCLLDDPF   WP  P+LPG++YSM+EQCRFD
Sbjct: 429 APLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFD 488

Query: 496 FGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKF-RPGAVAHACY 554
           FG GY  C AFRTF+PCKQLWCSHPDNPYFCKTKKGPPLDGT CAPGK+   G       
Sbjct: 489 FGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSP 548

Query: 555 PSTLGGQGRW 564
             T G  G W
Sbjct: 549 EQTYGQDGGW 558



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 8/81 (9%)

Query: 23   LPPPLLPPPPPPANARLAAAADPPGGPLG---HGAERILAVPVRTDAQGRLVSHVVSAAT 79
            LPP   P  P P     A AA+PPG P G   H   R   +P   D       H  +  T
Sbjct: 1114 LPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPET 1173

Query: 80   SRAGVRARRAAPVRTPSFPGG 100
               G     A+   +P+ PGG
Sbjct: 1174 PIPG-----ASWSISPTTPGG 1189


>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
           14 isoform 2 preproprotein [Homo sapiens]
          Length = 1223

 Score =  628 bits (1619), Expect = e-180
 Identities = 327/550 (59%), Positives = 382/550 (69%), Gaps = 26/550 (4%)

Query: 34  PANARLAAAADPPGGPL---GHGAERILAVPVRTDAQGRLVSHVVSA-ATSRAGVRARRA 89
           P +  L AAA      L   G  ++  + VP  TD +GR +SHVVS  A + AG      
Sbjct: 13  PLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDT 72

Query: 90  APV-----------RTPSFPGGN--EEEPGSH-LFYNVTVFGRDLHLRLRPNARLVAPGA 135
            P            R+P  PGG       G H L++NVTVFG++LHLRLRPN RLV PG+
Sbjct: 73  PPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGS 132

Query: 136 TMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLE 195
           ++EWQ +      +PL   C+Y G V G+  A+ VA+SNCDGLAGLIR +  +FFIEPLE
Sbjct: 133 SVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLE 191

Query: 196 KGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR 255
           +G   +EA  GR HVVYRR         P   D       L  L   LG++ +    + R
Sbjct: 192 RGQQEKEAS-GRTHVVYRREAVQQEWAEPDG-DLHNEAFGLGDLPNLLGLVGDQLGDTER 249

Query: 256 RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVL 315
           + RRHA    Y+IEVLL VDDSVV+FHGKEHVQ Y+LTLMNIV+EIYHDESLG HIN+ L
Sbjct: 250 K-RRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308

Query: 316 VRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSG 375
           VR+I++ Y +S+SLIE GNPS+SLE VCRWA+ QQ+ D  H E+HDH +FLTRQDFGPSG
Sbjct: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSG 368

Query: 376 MQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIM 435
              YAPVTGMCHP+RSC LNHEDGFSSAFV+AHETGHVLGMEHDGQGN C DE  LGS+M
Sbjct: 369 ---YAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVM 425

Query: 436 APLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFD 495
           APLVQAAFHRFHWSRCS+ ELSRYL SYDCLLDDPF   WP  P+LPG++YSM+EQCRFD
Sbjct: 426 APLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFD 485

Query: 496 FGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKF-RPGAVAHACY 554
           FG GY  C AFRTF+PCKQLWCSHPDNPYFCKTKKGPPLDGT CAPGK+   G       
Sbjct: 486 FGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSP 545

Query: 555 PSTLGGQGRW 564
             T G  G W
Sbjct: 546 EQTYGQDGGW 555



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 8/81 (9%)

Query: 23   LPPPLLPPPPPPANARLAAAADPPGGPLG---HGAERILAVPVRTDAQGRLVSHVVSAAT 79
            LPP   P  P P     A AA+PPG P G   H   R   +P   D       H  +  T
Sbjct: 1111 LPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPET 1170

Query: 80   SRAGVRARRAAPVRTPSFPGG 100
               G     A+   +P+ PGG
Sbjct: 1171 PIPG-----ASWSISPTTPGG 1186


>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif,
           6 preproprotein [Homo sapiens]
          Length = 1117

 Score =  249 bits (637), Expect = 4e-66
 Identities = 167/546 (30%), Positives = 264/546 (48%), Gaps = 64/546 (11%)

Query: 58  LAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFG 117
           L +P+R D  G  +S  V     +   R R   P+        + ++  S LF+ ++ +G
Sbjct: 44  LTIPIRVDQNGAFLSFTVK--NDKHSRRRRSMDPI--------DPQQAVSKLFFKLSAYG 93

Query: 118 RDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDG 177
           +  HL L  N   V+   T+E+ G+ G       L +C Y G +      + VALSNC G
Sbjct: 94  KHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVG 153

Query: 178 LAGLIRMEEEEFFIEPLEKGLAAQEA---EQGRVHVVYRRPPTSPP-------LGGPQAL 227
           L G+I  E+EE+FIEPL+      +    E G  HV+Y++              G     
Sbjct: 154 LHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFT 213

Query: 228 DTGAS--LDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKE 285
            +G    L+   ++S +L +   H +  ++R+       +  +E L+  D  +V +HG++
Sbjct: 214 RSGKPWWLNDTSTVSYSLPINNTHIHHRQKRS----VSIERFVETLVVADKMMVGYHGRK 269

Query: 286 HVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPS-QSLENVCR 344
            ++ Y+L++MNIV ++Y D SLG  +N+++ R+I+L+  +    +EI + + +SL++ C+
Sbjct: 270 DIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLT--EDQPNLEINHHADKSLDSFCK 327

Query: 345 WAYLQQKPDTGHDE-----------YHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHP 388
           W    QK    H             +HD+A+ +TR D       P G  G A V GMC P
Sbjct: 328 W----QKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEP 383

Query: 389 VRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDE-VRLGSIMAPLVQAAFHRFH 447
            RSC++N + G  SAF +AHE GH  GM HDG GN CG +      +MA  + A  + F 
Sbjct: 384 ERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFS 443

Query: 448 WSRCSQQELSRYLHS--YDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTA 505
           WS CS+  ++ +L S    CL ++P   D+      PG  Y  +EQCRF +G     C  
Sbjct: 444 WSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQC-- 501

Query: 506 FRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKFRPG------AVAHACYPSTL- 558
            +  + C++LWC    N   C T   P  +GT+C  G    G       V    +P ++ 
Sbjct: 502 -KYGEVCRELWCLSKSNR--CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSID 558

Query: 559 GGQGRW 564
           GG G W
Sbjct: 559 GGWGPW 564


>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
           7 preproprotein [Homo sapiens]
          Length = 1686

 Score =  239 bits (610), Expect = 5e-63
 Identities = 183/574 (31%), Positives = 263/574 (45%), Gaps = 66/574 (11%)

Query: 4   PAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVR 63
           P G + R   P L  LLLLL   L P  P PA          PG      A   +  PVR
Sbjct: 2   PGGPSPRSPAPLLRPLLLLLCA-LAPGAPGPA----------PGRATEGRAALDIVHPVR 50

Query: 64  TDAQGRLVSHVV-SAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHL 122
            DA G  +S+ +   A  +  V  RR AP                  FY +   GR+L  
Sbjct: 51  VDAGGSFLSYELWPRALRKRDVSVRRDAPA-----------------FYELQYRGRELRF 93

Query: 123 RLRPNARLVAPGATMEWQ--GEKGTTRVEPLLGSCLYVGDVAGLA-EASSVALSNCDGLA 179
            L  N  L+APG   E +  G  G   +     +C  +G+V     E    A+S CDGL 
Sbjct: 94  NLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLK 153

Query: 180 GLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR--PPTSPPLGGPQALDT-GASL-DS 235
           G+ ++  E++FIEPL+   A       + HVVY+R  P      G   A  T G  +   
Sbjct: 154 GVFQLSNEDYFIEPLDS--APARPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPE 211

Query: 236 LDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLM 295
           L+S        ++      RR  + +   +  +E L+  D  +V++HG+  V+ Y+LT+M
Sbjct: 212 LESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIM 271

Query: 296 NIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTG 355
           N+V  ++HD S+G  I++ +VR++LL   +   L    +   +L++ C+W          
Sbjct: 272 NMVAGLFHDPSIGNPIHITIVRLVLLE-DEEEDLKITHHADNTLKSFCKWQKSINMKGDA 330

Query: 356 HDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHET 410
           H  +HD AI LTR+D       P    G + V GMC P RSC++N + G   AF VAHE 
Sbjct: 331 HPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHEL 390

Query: 411 GHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYL-HSYDCLLDD 469
           GH  G++HDG GN C    +   IM+P +        WSRCS+Q ++R+L   +   LDD
Sbjct: 391 GHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDD 450

Query: 470 PFAH---DWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFC 526
           P A    D+P++P  PG+ Y ++ QCR  +G     C      + C  LWCS       C
Sbjct: 451 PPAKDIIDFPSVP--PGVLYDVSHQCRLQYGAYSAFCEDMD--NVCHTLWCSVGTT---C 503

Query: 527 KTKKGPPLDGTMCAPGK-----------FRPGAV 549
            +K    +DGT C   K           FRP AV
Sbjct: 504 HSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAV 537


>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
           motif, 16 preproprotein [Homo sapiens]
          Length = 1224

 Score =  238 bits (607), Expect = 1e-62
 Identities = 183/560 (32%), Positives = 263/560 (46%), Gaps = 82/560 (14%)

Query: 26  PLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVR 85
           P +P PPPPA        + PG       E  L      D +G  VSH +     R    
Sbjct: 40  PSVPRPPPPA--------ERPGWM--EKGEYDLVSAYEVDHRGDYVSHEIMHHQRR---- 85

Query: 86  ARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGT 145
            RRA PV          E    HL   +     D H+ LR ++ LVAPG  ++  G+ GT
Sbjct: 86  -RRAVPV---------SEVESLHL--RLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGT 133

Query: 146 TRVEPLLGS--CLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQ-- 201
             V+ L     C Y G +      SSVALS C GL+G+IR EE ++F+ PL   L+ +  
Sbjct: 134 KSVQTLPPEDFCFYQGSLRSHRN-SSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLG 192

Query: 202 EAEQGRV--HVVYRRPPTSPPLGGPQALDTGASLD----SLDSLSRALG----------- 244
            A QG    HV+Y+R       G  + L T  + +     L S    LG           
Sbjct: 193 RAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRR 252

Query: 245 -------------VLEEHANSSRRRAR---RHAADDDYNIEVLLGVDDSVVQFHGKEHVQ 288
                        +L +   S  R  R   R   +++ N+E L+ VD  ++Q HG E++ 
Sbjct: 253 KKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENIT 312

Query: 289 KYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYL 348
            Y+LT++N+V+ ++ D ++G +IN+ +V +ILL   +   L+   +   +L + C+W   
Sbjct: 313 TYVLTILNMVSALFKDGTIGGNINIAIVGLILLE-DEQPGLVISHHADHTLSSFCQW--- 368

Query: 349 QQKPDTGHD-EYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSS 402
            Q    G D   HDHAI LT  D       P    G+AP++GMC   RSCT+N + G   
Sbjct: 369 -QSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGL 427

Query: 403 AFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS 462
           AF +AHE+GH  GM HDG+GN C  +   G+IM+P +      F WS CS+Q L ++L +
Sbjct: 428 AFTIAHESGHNFGMIHDGEGNMC--KKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLST 485

Query: 463 YD--CLLDDPF-AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSH 519
               CL D P    ++    +LPG  Y  N QC++ FG    +C      D CK LWC  
Sbjct: 486 AQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHR 545

Query: 520 PDNPYFCKTKKGPPLDGTMC 539
                 C+TK  P  +GT+C
Sbjct: 546 IGRK--CETKFMPAAEGTIC 563


>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
           18 preproprotein [Homo sapiens]
          Length = 1221

 Score =  236 bits (603), Expect = 3e-62
 Identities = 172/554 (31%), Positives = 259/554 (46%), Gaps = 76/554 (13%)

Query: 35  ANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRT 94
           A+   A A+D   G  G   + +   PV  D+ G  +SH +       G + R A   R 
Sbjct: 40  ASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDIL----HNGRKKRSAQNAR- 94

Query: 95  PSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVE-PLLG 153
                       S L Y  + FG++LHL L+P+A +++    ++  G+ G +  + P + 
Sbjct: 95  ------------SSLHYRFSAFGQELHLELKPSA-ILSSHFIVQVLGKDGASETQKPEVQ 141

Query: 154 SCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRV----H 209
            C Y G +     +SSVA+S C GL+GLIR  + EF I PL + LA +           H
Sbjct: 142 QCFYQGFIRN-DSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPH 200

Query: 210 VVYRRPPTSP--------------PLGGPQALDTGASLDSLDSLSRALGV---------- 245
           V+Y+R                   P   P  +   +     +   R L            
Sbjct: 201 VLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKY 260

Query: 246 ------------LEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLT 293
                        +E+ +S R R     +    N+E L+  D  +V+ HGK +V  Y+LT
Sbjct: 261 APKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILT 320

Query: 294 LMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPD 353
           +MN+V+ ++ D ++G+ INVV+V +ILL       LI   +  QSL + C+W   Q    
Sbjct: 321 VMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLIN-HHADQSLNSFCQW---QSALI 376

Query: 354 TGHDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAH 408
             + + HDHAI LT  D       P    G+AP++GMC   RSCT+N + G   AF +AH
Sbjct: 377 GKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAH 436

Query: 409 ETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCL 466
           E+GH  GM HDG+GN C      G+IM+P +      F WS CS+Q L ++L +    CL
Sbjct: 437 ESGHNFGMIHDGEGNPC--RKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCL 494

Query: 467 LDDP-FAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF 525
           +D+P  A  +    +LPG  Y  + QC++ FG    +C+     D CK LWC      + 
Sbjct: 495 VDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVG--HR 552

Query: 526 CKTKKGPPLDGTMC 539
           C+TK  P  +GT+C
Sbjct: 553 CETKFMPAAEGTVC 566


>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif,
           9 preproprotein [Homo sapiens]
          Length = 1935

 Score =  231 bits (589), Expect = 1e-60
 Identities = 166/539 (30%), Positives = 261/539 (48%), Gaps = 63/539 (11%)

Query: 54  AERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNV 113
           +E  +  P+R +A G      V    +R   R+  +A    P+F   +     S   Y +
Sbjct: 46  SEYEIVSPIRVNALGEPFPTNVHFKRTR---RSINSATDPWPAFASSSSSSTSSQAHYRL 102

Query: 114 TVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRV------EPLLGSCLYVGDVAGLAEA 167
           + FG+     L  NA  +AP  T+   G  G  +       E  L  C Y G V   +E 
Sbjct: 103 SAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEH 162

Query: 168 SSVALSNCDGLAGLIRMEEEEFFIEPLEK-GLAAQEAEQGRVHVVYRRP-PTSPPLGGPQ 225
           ++V +S C G+ G  R  + ++FIEPL+       E EQ + H++YRR  P   P  G  
Sbjct: 163 TAV-ISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRH 221

Query: 226 ALDTGA-----SLDSLDSLSRALG-------------------VLEEHANSS-------- 253
           A DT       S D   + +R  G                       + N +        
Sbjct: 222 ACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRT 281

Query: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
            RR +R  +   + +EVL+  D+ +V +HG E++Q Y+LTLM+IV  IY D S+G  IN+
Sbjct: 282 HRRTKRFLSYPRF-VEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIGNLINI 339

Query: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
           V+V +I++   +    I   N   +L+N C+W + +  P   H   HD A+ LTRQD   
Sbjct: 340 VIVNLIVIHNEQDGPSISF-NAQTTLKNFCQWQHSKNSPGGIH---HDTAVLLTRQDICR 395

Query: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDE- 428
                   G A +  +C P RSC+++ + G S+AF +AHE GHV  M HD   N+C +E 
Sbjct: 396 AHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEG 454

Query: 429 -VRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPALPQLPGLH 485
                 +MAP +    + + WS+CS++ ++ +L +   +CLL++P +  +P   QLPG+ 
Sbjct: 455 VKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGIL 514

Query: 486 YSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPY-FCKTKKGPPLDGTMCAPGK 543
           Y++N+QC   FG G  +C        C++LWC++ +  +  C+T+  P  DGT C PGK
Sbjct: 515 YNVNKQCELIFGPGSQVCPYMM---QCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGK 570


>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
           10 preproprotein [Homo sapiens]
          Length = 1103

 Score =  222 bits (565), Expect = 8e-58
 Identities = 154/468 (32%), Positives = 228/468 (48%), Gaps = 55/468 (11%)

Query: 107 SHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAE 166
           S LFY V        L L  ++RL+A   ++E+   +G          CLY G + G A 
Sbjct: 74  SRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQAS 133

Query: 167 ASSVALSNCDGLAGLIRMEEEEFFIEPLEKG-LAAQEAEQGRVHVVYRRPPTSPPLGGPQ 225
            S VA+S C GL GLI  +EEE+ IEPL  G   ++  E+   HVVY+R     P     
Sbjct: 134 TSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSSLRHP----- 188

Query: 226 ALDTGASLDS----------LDSL----SRALGVLEEHANSSRRRARRHAADDDYNIEVL 271
            LDT   +            L +L    +R LG   E      +R+       +  +E L
Sbjct: 189 HLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRS----VSRERYVETL 244

Query: 272 LGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIE 331
           +  D  +V +HG+  V++Y+L +MNIV +++ D SLG+ +N+++ R+ILL+  +    +E
Sbjct: 245 VVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLT--EDQPTLE 302

Query: 332 IGNPS-QSLENVCRWAYLQQKPDTGHDEY-----------HDHAIFLTRQDF-----GPS 374
           I + + +SL++ C+W    QK    H  +           HD A+ +TR D       P 
Sbjct: 303 ITHHAGKSLDSFCKW----QKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPC 358

Query: 375 GMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVR-LGS 433
           G  G APV GMC   RSC++N + G ++AF +AHE GH  GM HDG GN CG   +    
Sbjct: 359 GTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAK 418

Query: 434 IMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPALPQLPGLHYSMNEQ 491
           +MA  +    + F WS CS+  ++ +L S    CL + P   D+      PG  Y  +EQ
Sbjct: 419 LMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQ 478

Query: 492 CRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMC 539
           CRF  G+    C   +  + C +LWC    N   C T   P  +GT+C
Sbjct: 479 CRFQHGVKSRQC---KYGEVCSELWCLSKSNR--CITNSIPAAEGTLC 521


>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
           type) with thrombospondin type 1 motif, 15 preproprotein
           [Homo sapiens]
          Length = 950

 Score =  206 bits (523), Expect = 6e-53
 Identities = 158/464 (34%), Positives = 220/464 (47%), Gaps = 30/464 (6%)

Query: 100 GNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGE--KGTTRVEPLLGSCLY 157
           G E+     L + +T F  D +L L P+A+ +AP  + E  G   +G T     L  C Y
Sbjct: 44  GPEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFY 103

Query: 158 VGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLA--AQEAEQGRVHVVYRRP 215
            GDV    + S  A+S C GL G       E+ I PL    A  AQ   QG  H++ RR 
Sbjct: 104 SGDVNAEPD-SFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQG-AHLLQRRG 161

Query: 216 PTSPPLGGPQALDTGAS------LDSLDSLS-RALGVLEEHANSSRRRARRHAADDDYNI 268
               P G P +    AS      L +LD    R  G  E  +     RA+R  +   Y +
Sbjct: 162 VPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRY-V 220

Query: 269 EVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMS 328
           E L+  D+S+V+FHG + ++ YLLTL+     +Y   S+   IN+V+V+++LL    S  
Sbjct: 221 ETLVVADESMVKFHGAD-LEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGP 279

Query: 329 LIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS---GMQGYAPVTGM 385
            +  GN + +L N C W     K    H EY D AI  TRQD   +      G A V  M
Sbjct: 280 KVT-GNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTM 338

Query: 386 CHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG--NRCGDEVRLGSIMAPLVQAAF 443
           C P RSC++  +DG  SAF  AHE GHV  M HD          ++R   +M+P +    
Sbjct: 339 CDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQID 398

Query: 444 HRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPALPQ-LPGLHYSMNEQCRFDFGLGY 500
               WS CS   ++ +L S   DCLLD P      +LP+ LPG  Y++++QC   FG+G 
Sbjct: 399 RANPWSACSAAIITDFLDSGHGDCLLDQPSKP--ISLPEDLPGASYTLSQQCELAFGVGS 456

Query: 501 MMCTAFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTMCAPGK 543
             C   +    C +LWC+        C+T+  P  DGT C  GK
Sbjct: 457 KPCPYMQY---CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGK 497


>gi|124430557 a disintegrin-like and metalloprotease with
           thrombospondin type 1 motifs 20 [Homo sapiens]
          Length = 1910

 Score =  205 bits (522), Expect = 8e-53
 Identities = 144/470 (30%), Positives = 226/470 (48%), Gaps = 50/470 (10%)

Query: 111 YNVTVFGRDLHLRLRPNARLVAPGATM---------EWQGEKGTTRVEPLLGSCLYVGDV 161
           Y  T +G+   L L  +A  +A G T           W+ + G +     L  C Y G V
Sbjct: 80  YRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSD----LRHCFYRGQV 135

Query: 162 AGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQG--RVHVVYRRPPTSP 219
               +  +V +S C GL G  + +  E+F+EP+ K     E E G  + H++YR+   + 
Sbjct: 136 NSQEDYKAV-VSLCGGLTGTFKGQNGEYFLEPIMKA-DGNEYEDGHNKPHLIYRQDLNNS 193

Query: 220 PL--------GGPQALDTGASLDSLDSLSRALGVLEEHA------NSSRRRARRHAADDD 265
            L           Q  +T     +  +++  L V++E        N   +  RRH+    
Sbjct: 194 FLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKR 253

Query: 266 Y-----NIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIIL 320
                  IE+++  D  VV  HG  ++Q Y+LTLM+IV  IY D S+G  I++V+V++++
Sbjct: 254 LISYPRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVM 312

Query: 321 LSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS----GM 376
           +   +   +I     + +L+N C W   Q   D  H  +HD A+ +TR+D   S     M
Sbjct: 313 IHREEEGPVINFDGAT-TLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNM 371

Query: 377 QGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGD-EVRLGSIM 435
            G + +  +C P++SC +N E G  SAF +AHE GH LG++HD    RC + +V    +M
Sbjct: 372 LGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHD-DNPRCKEMKVTKYHVM 430

Query: 436 APLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPALPQLPGLHYSMNEQCR 493
           AP +      + WS CS++ ++ +L +   +CLLD P    +    +LPG  Y  N+QC 
Sbjct: 431 APALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCE 490

Query: 494 FDFGLGYMMCTAFRTFDPCKQLWCSHPDNPY-FCKTKKGPPLDGTMCAPG 542
             FG G  MC        C  LWC+  +  +  C T+  PP DGT C PG
Sbjct: 491 LAFGPGSQMCPHINI---CMHLWCTSTEKLHKGCFTQHVPPADGTDCGPG 537


>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
           12 preproprotein [Homo sapiens]
          Length = 1594

 Score =  201 bits (510), Expect = 2e-51
 Identities = 155/528 (29%), Positives = 243/528 (46%), Gaps = 60/528 (11%)

Query: 61  PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120
           PVR DA G  +S+         G+     +  R     G  +      ++Y ++   +DL
Sbjct: 57  PVRVDASGHFLSY---------GLHYPITSSRRKRDLDGSED-----WVYYRISHEEKDL 102

Query: 121 HLRLRPNARLVAPGATMEWQ-GEKGTTRVEP-------LLGSCLYVGDVAGLAEASSVAL 172
              L  N   ++    ME + G     ++         L G+ L  G   G A     AL
Sbjct: 103 FFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTA-----AL 157

Query: 173 SNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR---PPTSPPLGGPQALDT 229
           S C GL G  ++   +FFIEP++K    +       H+VYRR   P T  P  G   L  
Sbjct: 158 SACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHP--HIVYRRQKVPETKEPTCG---LKD 212

Query: 230 GASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQK 289
             ++     L R     E H   SR  +RR  + + + +E L+  D  ++++HG E+V+ 
Sbjct: 213 SVNISQKQELWREKW--ERHNLPSRSLSRRSISKERW-VETLVVADTKMIEYHGSENVES 269

Query: 290 YLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQ 349
           Y+LT+MN+V  ++H+ S+G  I++V+VR+ILL   +   L  + +  ++L + C+W    
Sbjct: 270 YILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEE-EEQGLKIVHHAEKTLSSFCKWQKSI 328

Query: 350 QKPDTGHDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAF 404
                 +  +HD A+ LTR+D       P    G + ++GMC P RSC +N + G   AF
Sbjct: 329 NPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAF 388

Query: 405 VVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS-- 462
            +AHE GH  G++HDG+ N C    R   IM+  +Q       WS+CS++ ++R+L    
Sbjct: 389 TIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGW 448

Query: 463 YDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDN 522
             CL D P      +    PG+ Y ++ QC+  +G     C      + C+ LWCS    
Sbjct: 449 GFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVE--NVCQTLWCSVKG- 505

Query: 523 PYFCKTKKGPPLDGTMCAPGKFRPGAVAHACY------PSTLGGQGRW 564
             FC++K     DGT C   K+    +A  C        S  GG GRW
Sbjct: 506 --FCRSKLDAAADGTQCGEKKW---CMAGKCITVGKKPESIPGGWGRW 548


>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
           motif, 17 preproprotein [Homo sapiens]
          Length = 1095

 Score =  200 bits (509), Expect = 3e-51
 Identities = 180/551 (32%), Positives = 251/551 (45%), Gaps = 63/551 (11%)

Query: 27  LLPPPPPPANARLAAAADPPGGPLGHGA---ERILAVPVRTDAQGRLVSHVVSAATSRAG 83
           LLPP   P    L    DP G  +G  A   E +L   VR D         V      A 
Sbjct: 6   LLPPLVLPVLLLLVWGLDP-GTAVGDAAADVEVVLPWRVRPDD--------VHLPPLPAA 56

Query: 84  VRARRAAPVRTPSFPGGNEEEPGSH-LFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGE 142
              RR    RTP  P      PG   L  ++  FGRDL+L+LR + R ++ G  +E  G 
Sbjct: 57  PGPRRRRRPRTP--PAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGA 114

Query: 143 KGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCD---GLAGLIRMEEEEFFIEPLEKGLA 199
               R  P    C Y G V G    S V+LS C    GL GLI++ +E+  I+PL     
Sbjct: 115 -ARRRGRPA-ELCFYSGRVLG-HPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNN--- 168

Query: 200 AQEAEQGRVHVVYRR----PPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR 255
           +Q    GR H++ R+    P  S     P+ L    +     +  R      E  N+ R 
Sbjct: 169 SQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRL 228

Query: 256 RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVL 315
            +       ++ +E L+  D  +VQ+HG E  Q+++LT+MN+V  ++  +SLG  IN+ +
Sbjct: 229 TS-------EHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQV 281

Query: 316 VRIILLSYGKSMSLIEIGNPSQ-SLENVCRW--------AYL--QQKPDTGHD-EYHDHA 363
            +++LL   +  + + IG+  + SLE+ C W         YL   Q P    D    D A
Sbjct: 282 TKLVLLR--QRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAA 339

Query: 364 IFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH 418
           +F+TR DF      P    G A + G+C   R C L  ++G + AF +AHE GH LGM H
Sbjct: 340 VFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNH 399

Query: 419 DGQGNRCGDEVRLGSIMAPLVQAAF-HRFHWSRCSQQELSRYLHS--YDCLL-DDPFAHD 474
           D   + C     + S     V+        WS CS+ +L  +L S    CLL  DP +  
Sbjct: 400 DDDHSSCAGRSHIMS--GEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQH 457

Query: 475 WPALP-QLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPP 533
              LP +LPG+HYS NEQC+  FG+    C        C  LWC   +    CKTK  PP
Sbjct: 458 TVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHL-MCAGLWCL-VEGDTSCKTKLDPP 515

Query: 534 LDGTMCAPGKF 544
           LDGT C   K+
Sbjct: 516 LDGTECGADKW 526


>gi|112789555 ADAM metallopeptidase with thrombospondin type 1
           motif, 19 preproprotein [Homo sapiens]
          Length = 1207

 Score =  185 bits (469), Expect = 1e-46
 Identities = 149/491 (30%), Positives = 234/491 (47%), Gaps = 54/491 (10%)

Query: 91  PVRTPSFPGGNEEEP-GSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRV- 148
           P   PS P     EP G  +   +  F RDL+L LR + R +AP   +E +   G     
Sbjct: 146 PQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTG 205

Query: 149 --------EPLLGSCLYVGDVAGLAEASSVA-LSNCDG-LAGLIRMEEEEFFIEPLEKGL 198
                    P    C Y G V  L    S+A  S C G L G I++ E+  FIEPL   +
Sbjct: 206 AASAPQPPAPPDAGCFYTGAV--LRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTM 263

Query: 199 AAQEAEQGRVHVVYRRPPT-SPPLGGPQALDT---GASLDSLDSLSRALGVLEEHANSSR 254
           A      G  H VYR+  +    +    AL +   G   D     SR +      A S R
Sbjct: 264 AIT----GHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKI------AESGR 313

Query: 255 RRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVV 314
            +   +    +YNIE ++  D ++V +HG +  ++++LT++N+V  ++  +SL   +N+ 
Sbjct: 314 GKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLR 373

Query: 315 LVRIILLSYGKSMSLIEIGNPSQS-LENVCRW----------AYLQQKPDTGHDEYH-DH 362
           ++++ILL   ++   + IG+  +  LE+ C+W           +L+   + G D    D 
Sbjct: 374 VIKLILLH--ETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDA 431

Query: 363 AIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGME 417
           AI +TR+DF      P    G A ++GMC   R C +  ++G + AF +AHE GH +G+ 
Sbjct: 432 AILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGIN 491

Query: 418 HDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLD-DPFAHD 474
           HD     C D + + S    +         WSRCS+++L R+L S   +CLL  +P + +
Sbjct: 492 HDNDHPSCADGLHIMS-GEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVN 550

Query: 475 WPALP-QLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPP 533
              +P +LPG+ Y+ +EQC+  FG     C   +    C  LWC   +    C+TK  PP
Sbjct: 551 SVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHV-ICTGLWCK-VEGEKECRTKLDPP 608

Query: 534 LDGTMCAPGKF 544
           +DGT C  GK+
Sbjct: 609 MDGTDCDLGKW 619


>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
           motif, 8 preproprotein [Homo sapiens]
          Length = 889

 Score =  184 bits (466), Expect = 2e-46
 Identities = 159/500 (31%), Positives = 228/500 (45%), Gaps = 65/500 (13%)

Query: 88  RAAPVRTPSFPGGNEEE-------PGS--HLFYNVTVFGRDLHLRLRPNARLVAPGATME 138
           R AP R  +  GG   E       PGS   L  +++ FG+   LRL P+   +AP   +E
Sbjct: 25  RGAPARPAA--GGQASELVVPTRLPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIE 82

Query: 139 WQGEKG-TTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKG 197
             G  G  T  E  L  C + G V G  E S  A+S C GL+G   ++ EEF I+P  +G
Sbjct: 83  RLGGSGRATGGERGLRGCFFSGTVNGEPE-SLAAVSLCRGLSGSFLLDGEEFTIQP--QG 139

Query: 198 LAAQEAEQGRVH--------VVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEH 249
                A+  R+          + R P      G  Q  + G   +  +  S+     EE 
Sbjct: 140 AGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEESQ-----EEE 194

Query: 250 ANSSRR---------RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300
           A  +           R +R  ++  + +E LL  D S+  F+G + +Q ++LTLM++   
Sbjct: 195 AEGASEPPPPLGATSRTKRFVSEARF-VETLLVADASMAAFYGAD-LQNHILTLMSVAAR 252

Query: 301 IYHDESLGAHINVVLVRIILLS---YGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHD 357
           IY   S+   IN+++V+++++    +G  +S     N   +L N C W     +P   H 
Sbjct: 253 IYKHPSIKNSINLMVVKVLIVEDEKWGPEVS----DNGGLTLRNFCNWQRRFNQPSDRHP 308

Query: 358 EYHDHAIFLTRQDF-GPSGM---QGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHV 413
           E++D AI LTRQ+F G  G+    G A +  +C P +SC++  ++G  +A  +AHE GHV
Sbjct: 309 EHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHV 368

Query: 414 LGMEHDGQG--NRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDD 469
           L M HD      R    +    +MAPL         WS CS   L+  L     DCLLD 
Sbjct: 369 LSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDA 428

Query: 470 PFAHDWPALPQLPGLH-----YSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPY 524
           P A    ALP   GL      Y +++QCR  FG  +  C      D C QLWC       
Sbjct: 429 PAA----ALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEP 484

Query: 525 FCKTKKG--PPLDGTMCAPG 542
            C TK G  P  DGT C PG
Sbjct: 485 LCHTKNGSLPWADGTPCGPG 504


>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
           1 preproprotein [Homo sapiens]
          Length = 967

 Score =  175 bits (443), Expect = 1e-43
 Identities = 140/471 (29%), Positives = 211/471 (44%), Gaps = 54/471 (11%)

Query: 116 FGRDLHLRLRPNARLVAPGATMEWQGEKG---TTRVEPLLGSCLYVGDVAGLAEASSVAL 172
           F + L L LRP++  +APG T++  G K    T   E  L  C Y G V G   +S+ AL
Sbjct: 81  FDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNG-DPSSAAAL 139

Query: 173 SNCDGLAGLIRMEEEEFFIEPL----EKGLAAQEAEQG----RVHVVYR----------- 213
           S C+G+ G   +  E +FI+PL    E+   A   E+     + H++ R           
Sbjct: 140 SLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCG 199

Query: 214 ----------RPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAAD 263
                     +  T     G +  D GA     D   + +G   +   +   R +R  + 
Sbjct: 200 VVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVG---QPTGTGSIRKKRFVSS 256

Query: 264 DDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSY 323
             Y +E +L  D S+ +FHG   ++ YLLTL ++   +Y   S+   +++V+V+I+++ +
Sbjct: 257 HRY-VETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVI-H 313

Query: 324 GKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS---GMQGYA 380
            +        N + +L N C W      P     E++D AI  TRQD   S      G A
Sbjct: 314 DEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMA 373

Query: 381 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGS---IMAP 437
            V  +C P RSC++  +DG  +AF  AHE GHV  M HD    +C     +     +MA 
Sbjct: 374 DVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQCASLNGVNQDSHMMAS 432

Query: 438 LVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPALP-QLPGLHYSMNEQCRF 494
           ++    H   WS CS   ++ +L +   +CL+D P   +   LP  LPG  Y  N QC+F
Sbjct: 433 MLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP--QNPIQLPGDLPGTSYDANRQCQF 490

Query: 495 DFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGTMCAPGKF 544
            FG     C        C  LWC+        C+TK  P  DGT C  GK+
Sbjct: 491 TFGEDSKHCP--DAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKW 539


>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
           motif, 5 preproprotein [Homo sapiens]
          Length = 930

 Score =  166 bits (421), Expect = 4e-41
 Identities = 132/433 (30%), Positives = 199/433 (45%), Gaps = 60/433 (13%)

Query: 155 CLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHV---- 210
           C Y G V G   + +V    C GL G   ++   + ++PL +G  A+E E+GRV+     
Sbjct: 130 CFYRGTVDGSPRSLAV-FDLCGGLDGFFAVKHARYTLKPLLRGPWAEE-EKGRVYGDGSA 187

Query: 211 ----VYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR----------- 255
               VY R   S      +AL   AS ++  S   A      H+N S R           
Sbjct: 188 RILHVYTREGFSF-----EALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQS 242

Query: 256 --------------RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEI 301
                         R RR +      +E+LL  D S+ + +G+  +Q YLLTL +I N +
Sbjct: 243 ALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRG-LQHYLLTLASIANRL 301

Query: 302 YHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHD 361
           Y   S+  HI + +V++++L   K  SL    N + +L+N C+W +   +    H+E++D
Sbjct: 302 YSHASIENHIRLAVVKVVVLG-DKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD 360

Query: 362 HAIFLTRQDF---GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH 418
            AI  TR+D          G A V  +C P RSC +  +DG  +AF VAHE GH+LG+ H
Sbjct: 361 AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH 420

Query: 419 DGQGNRCGDEVRLGS-----IMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPF 471
           D     C  E   GS     +M+ ++ +      WS+C+   ++ +L     +CLLD P 
Sbjct: 421 D-DSKFC--EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLP- 476

Query: 472 AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCS-HPDNPYFCKTKK 530
                   +LPG  Y   +QC   FG  Y +C      D C +LWC+        C TKK
Sbjct: 477 RKQILGPEELPGQTYDATQQCNLTFGPEYSVCPG---MDVCARLWCAVVRQGQMVCLTKK 533

Query: 531 GPPLDGTMCAPGK 543
            P ++GT C  G+
Sbjct: 534 LPAVEGTPCGKGR 546


>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
           motif, 4 preproprotein [Homo sapiens]
          Length = 837

 Score =  155 bits (392), Expect = 9e-38
 Identities = 136/460 (29%), Positives = 205/460 (44%), Gaps = 54/460 (11%)

Query: 105 PGS----HLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSC----L 156
           PGS     L   +  FG  L L L  ++ +   G T+++ G+        LLG       
Sbjct: 73  PGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQ-----APELLGGAEPGTY 127

Query: 157 YVGDVAGLAEASSVALSNCDG--LAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR 214
             G + G  +  SVA  + DG  L G+++    E  ++PLE G        G  H++ R+
Sbjct: 128 LTGTING--DPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG-AHILRRK 184

Query: 215 PPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGV 274
            P S    GP             ++   LG      +   RRA+R A+   + +E L+  
Sbjct: 185 SPASGQ--GPMC-----------NVKAPLG----SPSPRPRRAKRFASLSRF-VETLVVA 226

Query: 275 DDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIG- 333
           DD +  FHG   +++YLLT+M    + +   S+   +++V+ R+++L  G+     ++G 
Sbjct: 227 DDKMAAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGP--QVGP 283

Query: 334 NPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF---GPSGMQGYAPVTGMCHPVR 390
           + +Q+L + C W      P+    ++ D AI  TRQD          G A V  +C P R
Sbjct: 284 SAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPAR 343

Query: 391 SCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG---NRCGDEVRLGSIMAPLVQAAFHRFH 447
           SC +  +DG  SAF  AHE GHV  M HD      +  G       +MAP++        
Sbjct: 344 SCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEP 403

Query: 448 WSRCSQQELSRYLHS--YDCLLDDPFAHDWPALP-QLPGLHYSMNEQCRFDFGLGYMMCT 504
           WS CS + ++ +L +    CLLD P A     LP   PG  Y  + QC+  FG     C 
Sbjct: 404 WSPCSARFITDFLDNGYGHCLLDKPEAP--LHLPVTFPGKDYDADRQCQLTFGPDSRHCP 461

Query: 505 AFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTMCAPGK 543
                 PC  LWCS H +    C+TK  P  DGT C P +
Sbjct: 462 QLP--PPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQ 499


>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
           13 isoform 2 preproprotein [Homo sapiens]
          Length = 1371

 Score =  140 bits (354), Expect = 2e-33
 Identities = 102/303 (33%), Positives = 148/303 (48%), Gaps = 17/303 (5%)

Query: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
           +R+ +R AA    ++E+L+ V   V Q H +E  ++Y+LT +NI  E+  D SLGA   V
Sbjct: 68  QRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRV 126

Query: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
            LV++++L+  +    I   N + SL +VC W+      D     + D  +++TR D   
Sbjct: 127 HLVKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185

Query: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG-QGNRCGDE 428
             G   ++G   + G C P  SC +  + GF     +AHE GH  G+EHDG  G+ CG  
Sbjct: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245

Query: 429 VRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPA---LPQLPG 483
              G +MA    A      WS CS+++L   L +    C+ D P      A       PG
Sbjct: 246 ---GHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPG 302

Query: 484 LHYSMNEQCRFDFGLGYMMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTMCAP 541
           L+YS NEQCR  FG   + CT  R   D C+ L C + P +   C     P LDGT C  
Sbjct: 303 LYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGV 362

Query: 542 GKF 544
            K+
Sbjct: 363 EKW 365


>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
           13 isoform 1 preproprotein [Homo sapiens]
          Length = 1427

 Score =  140 bits (354), Expect = 2e-33
 Identities = 102/303 (33%), Positives = 148/303 (48%), Gaps = 17/303 (5%)

Query: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
           +R+ +R AA    ++E+L+ V   V Q H +E  ++Y+LT +NI  E+  D SLGA   V
Sbjct: 68  QRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRV 126

Query: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
            LV++++L+  +    I   N + SL +VC W+      D     + D  +++TR D   
Sbjct: 127 HLVKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185

Query: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG-QGNRCGDE 428
             G   ++G   + G C P  SC +  + GF     +AHE GH  G+EHDG  G+ CG  
Sbjct: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245

Query: 429 VRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPA---LPQLPG 483
              G +MA    A      WS CS+++L   L +    C+ D P      A       PG
Sbjct: 246 ---GHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPG 302

Query: 484 LHYSMNEQCRFDFGLGYMMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTMCAP 541
           L+YS NEQCR  FG   + CT  R   D C+ L C + P +   C     P LDGT C  
Sbjct: 303 LYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGV 362

Query: 542 GKF 544
            K+
Sbjct: 363 EKW 365


>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
           13 isoform 3 preproprotein [Homo sapiens]
          Length = 1340

 Score =  125 bits (313), Expect = 1e-28
 Identities = 94/298 (31%), Positives = 137/298 (45%), Gaps = 38/298 (12%)

Query: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
           +R+ +R AA    ++E+L+ V   V Q H +E  ++Y+LT +NI  E+  D SLGA   V
Sbjct: 68  QRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRV 126

Query: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
            LV++++L+  +    I   N + SL +VC W+      D     + D  +++TR D   
Sbjct: 127 HLVKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185

Query: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG-QGNRCGDE 428
             G   ++G   + G C P  SC +  + GF     +AHE GH  G+EHDG  G+ CG  
Sbjct: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245

Query: 429 VRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSM 488
              G +MA    A      WS CS+++L   L                          S 
Sbjct: 246 ---GHVMASDGAAPRAGLAWSPCSRRQLLSLL--------------------------SA 276

Query: 489 NEQCRFDFGLGYMMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTMCAPGKF 544
           NEQCR  FG   + CT  R   D C+ L C + P +   C     P LDGT C   K+
Sbjct: 277 NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKW 334


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  107 bits (267), Expect = 3e-23
 Identities = 139/478 (29%), Positives = 196/478 (41%), Gaps = 63/478 (13%)

Query: 83  GVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGE 142
           G R RRA P      P          + Y +   G +  L LR N  L+  G T  +   
Sbjct: 39  GPRVRRALPSHLGLHP--------ERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAA 90

Query: 143 KGTTRVEPLLGS--CLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAA 200
            G+   E   G   C Y G V G  + S+ +LS C GL G  ++  +   IEPL++G   
Sbjct: 91  NGSEVTEQPRGQDHCFYQGHVEGYPD-SAASLSTCAGLRGFFQVGSDLHLIEPLDEG--- 146

Query: 201 QEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSL--SRALGVLEEH-ANSSRRRA 257
              E GR H VY+        G       G S DSL SL   R   V      +S   R 
Sbjct: 147 --GEGGR-HAVYQAEHLLQTAG-----TCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRE 198

Query: 258 RRHAADDDYNIEVLLGVDDSVVQFHGKE-HVQKYLLTLMNIVNEIYHDESLGAHINVVLV 316
            R+       +E+ + VD++  Q  G E  V+  +L ++N V+++Y       +  VVLV
Sbjct: 199 TRY-------VELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQK----LNFRVVLV 247

Query: 317 RIILLSYGKSMSLIEIG-NPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSG 375
               L    S     +  +PS +LEN+  W   Q+         HD+   +T  DF  + 
Sbjct: 248 G---LEIWNSQDRFHVSPDPSVTLENLLTWQARQRT----RRHLHDNVQLITGVDFTGTT 300

Query: 376 MQGYAPVTGMC-HPVRSCTLNH-EDGFSSAFVVAHETGHVLGMEHDG--QGNRCGDEVRL 431
           + G+A V+ MC H   +   +H ++    A  +AHE GH LGM+HD   QG RC +    
Sbjct: 301 V-GFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEA 359

Query: 432 G-SIMAPLVQAAFHRFHWSRCSQQELSRYLHSYD--CLLDDPFAHDWPALPQLPGLHYSM 488
           G  IMA  + ++F R  +S CSQ  L  +L      CL + P        P    L    
Sbjct: 360 GRCIMAGSIGSSFPRM-FSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVER 418

Query: 489 NEQCRFDFGLG---YMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGK 543
            EQC  D G        C    T    +   C+H      CK K      G +C P K
Sbjct: 419 GEQC--DCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPA----GELCRPKK 470


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 99/354 (27%), Positives = 147/354 (41%), Gaps = 36/354 (10%)

Query: 117 GRDLHLRLRPNARLVAPGATMEWQGEKGT--TRVEPLLGSCLYVGDVAGLAEASSVALSN 174
           GR+L L L  N +L AP  T       G   T    L   C Y G V    E SSV LS 
Sbjct: 73  GRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRE-TELSSVTLST 131

Query: 175 CDGLAGLIRMEEE-EFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASL 233
           C G+ GLI +     + IEPL              H++YR     PP G     + G   
Sbjct: 132 CRGIRGLITVSSNLSYVIEPLPDSKGQ--------HLIYRSEHLKPPPG-----NCGFEH 178

Query: 234 DSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEH--VQKYL 291
               +   AL   ++     RR  R       Y +E+ L  D    Q + ++    +  L
Sbjct: 179 SKPTTRDWALQFTQQTKKRPRRMKREDLNSMKY-VELYLVADYLEFQKNRRDQDATKHKL 237

Query: 292 LTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQK 351
           + + N V++ Y       +I + LV + + ++G    + E  NP  +L     W++L  +
Sbjct: 238 IEIANYVDKFYRS----LNIRIALVGLEVWTHGNMCEVSE--NPYSTL-----WSFLSWR 286

Query: 352 PDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLN---HEDGFSSAFVVAH 408
                 +YHD+A  +T   F  + + G AP+  MC   +S  +N    E+    A  +AH
Sbjct: 287 RKLLAQKYHDNAQLITGMSFHGTTI-GLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAH 345

Query: 409 ETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS 462
           E GH  GM HD            G IMA      F +  ++ C+++EL RYL S
Sbjct: 346 EMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKV-FNGCNRRELDRYLQS 398


>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
           [Homo sapiens]
          Length = 540

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 112/494 (22%), Positives = 192/494 (38%), Gaps = 55/494 (11%)

Query: 70  LVSHVVSAATSRAGVRARRAA-PVRTPSFPGGNEEEPG------SHLFYNVTVFGRDLHL 122
           L+S  VSA     GV+      P+R         +EP       + L Y +T+ G+   L
Sbjct: 11  LLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVL 70

Query: 123 RLRPNARLVAPGATMEWQGEKGT--TRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG 180
            L+ N  L+APG T  +    G   T    ++  C Y G +    + S  ++S C GL G
Sbjct: 71  YLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILN-EKVSDASISTCRGLRG 129

Query: 181 LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS 240
                ++ +FIEPL     +     G+ H +++  P        +  D+   +D +    
Sbjct: 130 YFSQGDQRYFIEPL-----SPIHRDGQEHALFKYNPDE------KNYDSTCGMDGVLWAH 178

Query: 241 RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFH--GKEHVQKYLLTLMNIV 298
                +   A    +   R   + +  IE  L +D+   + +   ++ ++K +  + N V
Sbjct: 179 DLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238

Query: 299 NEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDE 358
           N +Y  + L  H+ +V + I    +     +    N S +LEN  +W    +       +
Sbjct: 239 NMLY--KKLNTHVALVGMEI----WTDKDKIKITPNASFTLENFSKW----RGSVLSRRK 288

Query: 359 YHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVR-SCTLNHEDG-FSSAFVVAHETGHVLGM 416
            HD A  +T  +   + + G A ++ MC P       +H D     A  +AHE GH  GM
Sbjct: 289 RHDIAQLITATELAGTTV-GLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGM 347

Query: 417 EHDGQGNRCGDEV----RLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFA 472
            HD    +C   +    +  S   P   ++  R  + +  + +LS      +CL + P  
Sbjct: 348 FHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLS------NCLFNAPLP 401

Query: 473 HDWPALPQLPGLHYSMNEQCRFDFGLG---YMMCTAFRTFDPCKQLWCSHPDNPYFCKTK 529
            D  + P        M E C  D G       +C   +T        C+  +    C+ K
Sbjct: 402 TDIISTPICGNQLVEMGEDC--DCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFK 459

Query: 530 KGPPLDGTMCAPGK 543
           K     G +C P K
Sbjct: 460 KA----GMVCRPAK 469


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 112/494 (22%), Positives = 192/494 (38%), Gaps = 55/494 (11%)

Query: 70  LVSHVVSAATSRAGVRARRAA-PVRTPSFPGGNEEEPG------SHLFYNVTVFGRDLHL 122
           L+S  VSA     GV+      P+R         +EP       + L Y +T+ G+   L
Sbjct: 11  LLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVL 70

Query: 123 RLRPNARLVAPGATMEWQGEKGT--TRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG 180
            L+ N  L+APG T  +    G   T    ++  C Y G +    + S  ++S C GL G
Sbjct: 71  YLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILN-EKVSDASISTCRGLRG 129

Query: 181 LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS 240
                ++ +FIEPL     +     G+ H +++  P        +  D+   +D +    
Sbjct: 130 YFSQGDQRYFIEPL-----SPIHRDGQEHALFKYNPDE------KNYDSTCGMDGVLWAH 178

Query: 241 RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFH--GKEHVQKYLLTLMNIV 298
                +   A    +   R   + +  IE  L +D+   + +   ++ ++K +  + N V
Sbjct: 179 DLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238

Query: 299 NEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDE 358
           N +Y  + L  H+ +V + I    +     +    N S +LEN  +W    +       +
Sbjct: 239 NMLY--KKLNTHVALVGMEI----WTDKDKIKITPNASFTLENFSKW----RGSVLSRRK 288

Query: 359 YHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVR-SCTLNHEDG-FSSAFVVAHETGHVLGM 416
            HD A  +T  +   + + G A ++ MC P       +H D     A  +AHE GH  GM
Sbjct: 289 RHDIAQLITATELAGTTV-GLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGM 347

Query: 417 EHDGQGNRCGDEV----RLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFA 472
            HD    +C   +    +  S   P   ++  R  + +  + +LS      +CL + P  
Sbjct: 348 FHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLS------NCLFNAPLP 401

Query: 473 HDWPALPQLPGLHYSMNEQCRFDFGLG---YMMCTAFRTFDPCKQLWCSHPDNPYFCKTK 529
            D  + P        M E C  D G       +C   +T        C+  +    C+ K
Sbjct: 402 TDIISTPICGNQLVEMGEDC--DCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFK 459

Query: 530 KGPPLDGTMCAPGK 543
           K     G +C P K
Sbjct: 460 KA----GMVCRPAK 469


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 90/356 (25%), Positives = 146/356 (41%), Gaps = 41/356 (11%)

Query: 118 RDLHLRLRPNARLVAPGATMEWQGEKGTT-----RVEPLLGSCLYVGDVAGLAEASSVAL 172
           ++L + L  N  L+A   T     + GT          +LG C Y G V G ++ S+V+L
Sbjct: 77  KELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSD-SAVSL 135

Query: 173 SNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGAS 232
           S C GL GLI  E E + +EP++                  R    P         +  S
Sbjct: 136 STCSGLRGLIVFENESYVLEPMKSAT--------------NRYKLFPAKKLKSVRGSCGS 181

Query: 233 LDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGK--EHVQKY 290
             +  +L+ A  V    + +  RR +R        +E+++  D+   Q  GK  E V++ 
Sbjct: 182 HHNTPNLA-AKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240

Query: 291 LLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQ 350
           L+ + N V++ Y       +I +VLV + + +     S+ +  +P  SL     W  ++ 
Sbjct: 241 LIEIANHVDKFYRP----LNIRIVLVGVEVWNDMDKCSVSQ--DPFTSLHEFLDWRKMKL 294

Query: 351 KPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRS--CTLNHEDG-FSSAFVVA 407
            P   HD        L    +      G AP+  MC   +S    ++H D    +A  +A
Sbjct: 295 LPRKSHDNAQ-----LVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLA 349

Query: 408 HETGHVLGMEHDGQGNRCGDEVRL---GSIMAPLVQAAFHRFHWSRCSQQELSRYL 460
           HE GH  GM HD     C  ++ +   G IM       F    +S CS+++L   L
Sbjct: 350 HELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMV-FSSCSRKDLETSL 404


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 90/356 (25%), Positives = 146/356 (41%), Gaps = 41/356 (11%)

Query: 118 RDLHLRLRPNARLVAPGATMEWQGEKGTT-----RVEPLLGSCLYVGDVAGLAEASSVAL 172
           ++L + L  N  L+A   T     + GT          +LG C Y G V G ++ S+V+L
Sbjct: 77  KELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSD-SAVSL 135

Query: 173 SNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGAS 232
           S C GL GLI  E E + +EP++                  R    P         +  S
Sbjct: 136 STCSGLRGLIVFENESYVLEPMKSAT--------------NRYKLFPAKKLKSVRGSCGS 181

Query: 233 LDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGK--EHVQKY 290
             +  +L+ A  V    + +  RR +R        +E+++  D+   Q  GK  E V++ 
Sbjct: 182 HHNTPNLA-AKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240

Query: 291 LLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQ 350
           L+ + N V++ Y       +I +VLV + + +     S+ +  +P  SL     W  ++ 
Sbjct: 241 LIEIANHVDKFYRP----LNIRIVLVGVEVWNDMDKCSVSQ--DPFTSLHEFLDWRKMKL 294

Query: 351 KPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRS--CTLNHEDG-FSSAFVVA 407
            P   HD        L    +      G AP+  MC   +S    ++H D    +A  +A
Sbjct: 295 LPRKSHDNAQ-----LVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLA 349

Query: 408 HETGHVLGMEHDGQGNRCGDEVRL---GSIMAPLVQAAFHRFHWSRCSQQELSRYL 460
           HE GH  GM HD     C  ++ +   G IM       F    +S CS+++L   L
Sbjct: 350 HELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMV-FSSCSRKDLETSL 404


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 106/457 (23%), Positives = 192/457 (42%), Gaps = 73/457 (15%)

Query: 109 LFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGT--TRVEPLLGSCLYVGDVAGLAE 166
           L Y + +  + L L L  +   +    +  +   KG   TR   ++  C Y G +    +
Sbjct: 59  LLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYD 118

Query: 167 ASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQA 226
            S+ ++S C+GL G  R+ ++ + IEP++       +++G  H+V++     P       
Sbjct: 119 -SAASISTCNGLRGFFRINDQRYLIEPVKY------SDEGE-HLVFKYNLRVP------- 163

Query: 227 LDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEH 286
                S   L+   + +       N S   ++     D+  +E+ +  DD+V + +G  H
Sbjct: 164 YGANYSCTELNFTRKTV----PGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPH 219

Query: 287 --VQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCR 344
             ++  +  ++N VN IY       +I+V LV I + ++   + L      S     + R
Sbjct: 220 NKLRNRIWGMVNFVNMIYKT----LNIHVTLVGIEIWTHEDKIELY-----SNIETTLLR 270

Query: 345 WAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHE---DGFS 401
           +++ Q+K      ++ DH + L+ + +  S +QG +   GMC P  S ++  +   D   
Sbjct: 271 FSFWQEKILKTRKDF-DHVVLLSGK-WLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNI 328

Query: 402 SAFVVAHETGHVLGMEHDGQGNRCGDEVRL----GSIMAPLVQAAFHRFHWSRCSQQELS 457
            A  +AH+ GH LGM+HD     C     +    GSI A           +S+CSQ +  
Sbjct: 329 IANRMAHQLGHNLGMQHDEFPCTCPSGKCVMDSDGSIPA---------LKFSKCSQNQYH 379

Query: 458 RYLHSY--DCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPC--- 512
           +YL  Y   C+L+ PF +++              E+C  D G     CT     +PC   
Sbjct: 380 QYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEEC--DCGPA-QECT-----NPCCDA 431

Query: 513 ------KQLWCSHPDNPYFCKTKKGPPLDGTMCAPGK 543
                     C+  +    C+ KK     G++C P K
Sbjct: 432 HTCVLKPGFTCAEGECCESCQIKKA----GSICRPAK 464


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,659,260
Number of Sequences: 37866
Number of extensions: 1420577
Number of successful extensions: 13307
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 191
Number of HSP's that attempted gapping in prelim test: 10276
Number of HSP's gapped (non-prelim): 2333
length of query: 566
length of database: 18,247,518
effective HSP length: 108
effective length of query: 458
effective length of database: 14,157,990
effective search space: 6484359420
effective search space used: 6484359420
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.