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Search of human proteins with 11038637
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo
sapiens]
(938 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 1877 0.0
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 1788 0.0
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 1732 0.0
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 312 1e-84
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 298 2e-80
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 298 2e-80
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 298 2e-80
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 273 7e-73
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 265 1e-70
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 263 6e-70
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 258 1e-68
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 255 2e-67
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 253 4e-67
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 252 1e-66
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 251 2e-66
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 248 2e-65
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 244 2e-64
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 244 4e-64
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 243 5e-64
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 241 2e-63
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 236 7e-62
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 235 2e-61
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 235 2e-61
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 223 6e-58
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 222 1e-57
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 218 2e-56
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 218 2e-56
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 203 5e-52
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 198 2e-50
gi|37577159 calcium-sensing receptor [Homo sapiens] 60 1e-08
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 1877 bits (4863), Expect = 0.0
Identities = 938/938 (100%), Positives = 938/938 (100%)
Query: 1 MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60
MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
Sbjct: 1 MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60
Query: 61 NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120
NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
Sbjct: 61 NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120
Query: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180
LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL
Sbjct: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180
Query: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240
ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM
Sbjct: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240
Query: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300
TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
Sbjct: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300
Query: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
Sbjct: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
Query: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420
LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC
Sbjct: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420
Query: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480
KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
Sbjct: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480
Query: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540
DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
Sbjct: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540
Query: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
Sbjct: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
Query: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660
LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
Sbjct: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660
Query: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720
EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
Sbjct: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720
Query: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780
VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
Sbjct: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780
Query: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840
ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
Sbjct: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840
Query: 841 KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT
Sbjct: 841 KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
Query: 901 STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES 938
STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
Sbjct: 901 STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES 938
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 1788 bits (4632), Expect = 0.0
Identities = 901/938 (96%), Positives = 901/938 (96%), Gaps = 37/938 (3%)
Query: 1 MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60
MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
Sbjct: 1 MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60
Query: 61 NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120
NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
Sbjct: 61 NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120
Query: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180
LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL
Sbjct: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180
Query: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240
ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM
Sbjct: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240
Query: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300
TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
Sbjct: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300
Query: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
Sbjct: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
Query: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420
LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC
Sbjct: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420
Query: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480
KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
Sbjct: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480
Query: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540
DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
Sbjct: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540
Query: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
Sbjct: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
Query: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660
LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
Sbjct: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660
Query: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720
EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
Sbjct: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720
Query: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780
VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
Sbjct: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780
Query: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840
ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
Sbjct: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840
Query: 841 KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
KDARRKQMQLAFAAVNVWRKNLQ
Sbjct: 841 KDARRKQMQLAFAAVNVWRKNLQ------------------------------------- 863
Query: 901 STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES 938
STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
Sbjct: 864 STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES 901
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 1732 bits (4485), Expect = 0.0
Identities = 863/863 (100%), Positives = 863/863 (100%)
Query: 1 MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60
MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
Sbjct: 1 MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60
Query: 61 NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120
NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
Sbjct: 61 NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120
Query: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180
LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL
Sbjct: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180
Query: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240
ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM
Sbjct: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240
Query: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300
TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
Sbjct: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300
Query: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
Sbjct: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
Query: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420
LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC
Sbjct: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420
Query: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480
KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
Sbjct: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480
Query: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540
DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
Sbjct: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540
Query: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
Sbjct: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
Query: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660
LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
Sbjct: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660
Query: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720
EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
Sbjct: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720
Query: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780
VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
Sbjct: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780
Query: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840
ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
Sbjct: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840
Query: 841 KDARRKQMQLAFAAVNVWRKNLQ 863
KDARRKQMQLAFAAVNVWRKNLQ
Sbjct: 841 KDARRKQMQLAFAAVNVWRKNLQ 863
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 312 bits (799), Expect = 1e-84
Identities = 244/863 (28%), Positives = 440/863 (50%), Gaps = 71/863 (8%)
Query: 6 LLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSW--KIQLNAT 63
L+ L S S AR+ P + I +L E ++A + + H S +++L A
Sbjct: 14 LVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAM 73
Query: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
+ T + I +C DL+S + +V T + + + + P+LG+
Sbjct: 74 NETDPKSIITR---IC-DLMSDRKIQGVVFADDTDQEAIAQI-LDFISAQTLTPILGIHG 128
Query: 124 RMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG-RAAQKRLE 181
S I +DK F + P Q+SV +M Y W +I +V+ G + ++
Sbjct: 129 GSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDW-YIFSIVTTYFPGYQDFVNKIR 187
Query: 182 TLLEERES--KAEKVLQFDPGTKNVTALLM-EAKELEARVIILSASEDDAATVYRAAAML 238
+ +E + E+VL D + + + + K+L++ +I+L ++++A ++ A +
Sbjct: 188 STIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSV 247
Query: 239 NMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNES----AHISDAVGVVAQAVHE 294
+TG GY W+V ++G+ + GL ++ A + D + ++ A +
Sbjct: 248 GLTGYGYTWIVPSL-VAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASD 306
Query: 295 LLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSS---KYADGVT--GR-VEFNEDGDRKF 348
+L + + P+ NT+ KR+ S+ +Y VT GR + F+EDG +
Sbjct: 307 MLSEHSFIPEPKSSCYNTHE-------KRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMH 359
Query: 349 ANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPG--GETEKPRGYQMSTRLKIVTIHQ 405
I+ L + RK +VG + + + +WP ETE+ Q L IVT+ +
Sbjct: 360 PKLVIILLNKERKWERVGKWKDKSL--QMKYYVWPRMCPETEE----QEDDHLSIVTLEE 413
Query: 406 EPFVYVKPTLS-DGTCKEEFTVNGDPVKKVICT-GPNDTSPGSPRHTVPQCCYGFCIDLL 463
PFV V+ GTC N P +K I T D PG + +CC GFCID+L
Sbjct: 414 APFVIVESVDPLSGTCMR----NTVPCQKRIVTENKTDEEPGY----IKKCCKGFCIDIL 465
Query: 464 IKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNER 523
K+++++ FTY+++LV +GK G +++N + WNGM+GE++ +A M V LTIN ER
Sbjct: 466 KKISKSVKFTYDLYLVTNGKHG--KKINGT----WNGMIGEVVMKRAYMAVGSLTINEER 519
Query: 524 AQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDR 582
++ ++FS PF G++++V + + +F++PF + +W+++ + + +V AV +++ +
Sbjct: 520 SEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEY 579
Query: 583 FSPFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFA 640
FSP G R + E + T+ A+W WG++ N+ + P+ +++I+ VWA FA
Sbjct: 580 FSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFA 639
Query: 641 MIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQV 697
+I +ASYTANLAAF++ + ++++G++D + + P+D F + TV S + R
Sbjct: 640 VIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRN-- 697
Query: 698 ELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELF 753
+ M+ +M K N +A+ +++ KL AFI+D+AVL + A + C LVT +G++F
Sbjct: 698 NYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVF 757
Query: 754 FRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFE 811
+G+GI ++KDS WK+ V L+IL+ +G ME+L+ W+ C + N + L +
Sbjct: 758 ASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT-GICHNEKNEVMSSQLDID 816
Query: 812 NMAGVFMLVAGGIVAGIFLIFIE 834
NMAGVF ++ + + E
Sbjct: 817 NMAGVFYMLGAAMALSLITFICE 839
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 298 bits (762), Expect = 2e-80
Identities = 215/741 (29%), Positives = 388/741 (52%), Gaps = 46/741 (6%)
Query: 116 IPVLGLTTRMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG- 173
+P+LG+ S I +DK +F + Q++V ++M+ Y W H+ LV+ G
Sbjct: 122 VPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW-HVFSLVTTIFPGY 180
Query: 174 RAAQKRLETLLEERES--KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATV 231
R ++T ++ + V+ D ++ + + K++ + VI+L S+D+A +
Sbjct: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLI 239
Query: 232 YRAAAMLNMTGSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKNE-SAHISDAVGV 287
A L +TG + W+V +SGN + P G++ + + A + D +G+
Sbjct: 240 LSEARSLGLTGYDFFWIVPSL-VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGI 298
Query: 288 VAQAVHELLEKEN-ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDR 346
+ A +LEK + I + C G + M + DG + F E+G +
Sbjct: 299 LTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKD--LSFTEEGYQ 356
Query: 347 KFANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQ 405
++ L ++R+ +VG + H + + R +WP ++ L IVT+ +
Sbjct: 357 VHPRLVVIVLNKDREWEKVGKWEN-HTL-SLRHAVWPRYKSFSDCEPD-DNHLSIVTLEE 413
Query: 406 EPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIK 465
PFV V+ E N P +K + N T+ G V +CC GFCID+L K
Sbjct: 414 APFVIVEDI---DPLTETCVRNTVPCRKFVKIN-NSTNEGM---NVKKCCKGFCIDILKK 466
Query: 466 LARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQ 525
L+RT+ FTY+++LV +GK G ++VNN WNGM+GE++ +A M V LTIN ER++
Sbjct: 467 LSRTVKFTYDLYLVTNGKHG--KKVNNV----WNGMIGEVVYQRAVMAVGSLTINEERSE 520
Query: 526 YIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDRFS 584
++FS PF G++++V + + +F++PF +++W+++ + + +V A+ +++ + FS
Sbjct: 521 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFS 580
Query: 585 PFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
P G R + + T+ A+W WG++ N+ + P+ +++I+ VWA FA+I
Sbjct: 581 PVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVI 640
Query: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQVEL 699
+ASYTANLAAF++ + +++TG++D + + P D F + TV S + R
Sbjct: 641 FLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY 700
Query: 700 STMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFR 755
M+++M K N + +A+ +++ KL AFI+D+AVL ++A + C LVT +G +F
Sbjct: 701 --MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 758
Query: 756 SGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFENM 813
+G+GI ++K SPWK+ + L++L+ +G ME+L+ W+ C + N + L +NM
Sbjct: 759 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT-GICHNEKNEVMSSQLDIDNM 817
Query: 814 AGVFMLVAGGIVAGIFLIFIE 834
AGVF ++A + + E
Sbjct: 818 AGVFYMLAAAMALSLITFIWE 838
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 298 bits (762), Expect = 2e-80
Identities = 215/741 (29%), Positives = 388/741 (52%), Gaps = 46/741 (6%)
Query: 116 IPVLGLTTRMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG- 173
+P+LG+ S I +DK +F + Q++V ++M+ Y W H+ LV+ G
Sbjct: 122 VPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW-HVFSLVTTIFPGY 180
Query: 174 RAAQKRLETLLEERES--KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATV 231
R ++T ++ + V+ D ++ + + K++ + VI+L S+D+A +
Sbjct: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLI 239
Query: 232 YRAAAMLNMTGSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKNE-SAHISDAVGV 287
A L +TG + W+V +SGN + P G++ + + A + D +G+
Sbjct: 240 LSEARSLGLTGYDFFWIVPSL-VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGI 298
Query: 288 VAQAVHELLEKEN-ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDR 346
+ A +LEK + I + C G + M + DG + F E+G +
Sbjct: 299 LTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKD--LSFTEEGYQ 356
Query: 347 KFANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQ 405
++ L ++R+ +VG + H + + R +WP ++ L IVT+ +
Sbjct: 357 VHPRLVVIVLNKDREWEKVGKWEN-HTL-SLRHAVWPRYKSFSDCEPD-DNHLSIVTLEE 413
Query: 406 EPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIK 465
PFV V+ E N P +K + N T+ G V +CC GFCID+L K
Sbjct: 414 APFVIVEDI---DPLTETCVRNTVPCRKFVKIN-NSTNEGM---NVKKCCKGFCIDILKK 466
Query: 466 LARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQ 525
L+RT+ FTY+++LV +GK G ++VNN WNGM+GE++ +A M V LTIN ER++
Sbjct: 467 LSRTVKFTYDLYLVTNGKHG--KKVNNV----WNGMIGEVVYQRAVMAVGSLTINEERSE 520
Query: 526 YIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDRFS 584
++FS PF G++++V + + +F++PF +++W+++ + + +V A+ +++ + FS
Sbjct: 521 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFS 580
Query: 585 PFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
P G R + + T+ A+W WG++ N+ + P+ +++I+ VWA FA+I
Sbjct: 581 PVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVI 640
Query: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQVEL 699
+ASYTANLAAF++ + +++TG++D + + P D F + TV S + R
Sbjct: 641 FLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY 700
Query: 700 STMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFR 755
M+++M K N + +A+ +++ KL AFI+D+AVL ++A + C LVT +G +F
Sbjct: 701 --MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 758
Query: 756 SGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFENM 813
+G+GI ++K SPWK+ + L++L+ +G ME+L+ W+ C + N + L +NM
Sbjct: 759 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT-GICHNEKNEVMSSQLDIDNM 817
Query: 814 AGVFMLVAGGIVAGIFLIFIE 834
AGVF ++A + + E
Sbjct: 818 AGVFYMLAAAMALSLITFIWE 838
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 298 bits (762), Expect = 2e-80
Identities = 215/741 (29%), Positives = 388/741 (52%), Gaps = 46/741 (6%)
Query: 116 IPVLGLTTRMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG- 173
+P+LG+ S I +DK +F + Q++V ++M+ Y W H+ LV+ G
Sbjct: 122 VPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW-HVFSLVTTIFPGY 180
Query: 174 RAAQKRLETLLEERES--KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATV 231
R ++T ++ + V+ D ++ + + K++ + VI+L S+D+A +
Sbjct: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLI 239
Query: 232 YRAAAMLNMTGSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKNE-SAHISDAVGV 287
A L +TG + W+V +SGN + P G++ + + A + D +G+
Sbjct: 240 LSEARSLGLTGYDFFWIVPSL-VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGI 298
Query: 288 VAQAVHELLEKEN-ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDR 346
+ A +LEK + I + C G + M + DG + F E+G +
Sbjct: 299 LTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKD--LSFTEEGYQ 356
Query: 347 KFANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQ 405
++ L ++R+ +VG + H + + R +WP ++ L IVT+ +
Sbjct: 357 VHPRLVVIVLNKDREWEKVGKWEN-HTL-SLRHAVWPRYKSFSDCEPD-DNHLSIVTLEE 413
Query: 406 EPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIK 465
PFV V+ E N P +K + N T+ G V +CC GFCID+L K
Sbjct: 414 APFVIVEDI---DPLTETCVRNTVPCRKFVKIN-NSTNEGM---NVKKCCKGFCIDILKK 466
Query: 466 LARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQ 525
L+RT+ FTY+++LV +GK G ++VNN WNGM+GE++ +A M V LTIN ER++
Sbjct: 467 LSRTVKFTYDLYLVTNGKHG--KKVNNV----WNGMIGEVVYQRAVMAVGSLTINEERSE 520
Query: 526 YIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDRFS 584
++FS PF G++++V + + +F++PF +++W+++ + + +V A+ +++ + FS
Sbjct: 521 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFS 580
Query: 585 PFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
P G R + + T+ A+W WG++ N+ + P+ +++I+ VWA FA+I
Sbjct: 581 PVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVI 640
Query: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQVEL 699
+ASYTANLAAF++ + +++TG++D + + P D F + TV S + R
Sbjct: 641 FLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY 700
Query: 700 STMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFR 755
M+++M K N + +A+ +++ KL AFI+D+AVL ++A + C LVT +G +F
Sbjct: 701 --MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 758
Query: 756 SGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFENM 813
+G+GI ++K SPWK+ + L++L+ +G ME+L+ W+ C + N + L +NM
Sbjct: 759 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT-GICHNEKNEVMSSQLDIDNM 817
Query: 814 AGVFMLVAGGIVAGIFLIFIE 834
AGVF ++A + + E
Sbjct: 818 AGVFYMLAAAMALSLITFIWE 838
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 273 bits (697), Expect = 7e-73
Identities = 222/824 (26%), Positives = 396/824 (48%), Gaps = 66/824 (8%)
Query: 116 IPVLGLTTRMSIY-SDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR 174
+P+L ++ ++ + K +FL+ Q V F+++ Y W+ ++ S H G
Sbjct: 117 VPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSL-HPGH 175
Query: 175 AAQKRLETLLEERESKAEKVL-----QFDPGTKNVTALLMEAKELEARVIILSASEDDAA 229
A + + + ++L + PG + ++L+A V + S ++A
Sbjct: 176 ALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRL-LRQLDAPVFVAYCSREEAE 234
Query: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHIS------D 283
++ AA + G G+VWLV + AP + LI+ ES +S D
Sbjct: 235 VLFAEAAQAGLVGPGHVWLVPNLALGSTD---APPATFPVGLISVVTESWRLSLRQKVRD 291
Query: 284 AVGVVAQAVHELLEKENITDPPRG-C-VGNTNIWKTGPLFKRVLMSSKYADGVTGR-VEF 340
V ++A H + P G C V + F R L++ + GR F
Sbjct: 292 GVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWE----GRDFSF 347
Query: 341 NEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKI 400
+ G ++ L +L ++ + H + + +WP S L +
Sbjct: 348 SPGGYLVQPTMVVIALNRHRLWEM-VGRWEHGVLYMKYPVWPRYSASLQPVVD-SRHLTV 405
Query: 401 VTIHQEPFVYVK-PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC 459
T+ + PFV V+ P G C N P ++ + S G CC GFC
Sbjct: 406 ATLEERPFVIVESPDPGTGGC----VPNTVPCRR---QSNHTFSSGDVAPYTKLCCKGFC 458
Query: 460 IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTI 519
ID+L KLAR + F+Y+++LV +GK G + R WNGM+GE+ +ADM + LTI
Sbjct: 459 IDILKKLARVVKFSYDLYLVTNGKHGKRVR------GVWNGMIGEVYYKRADMAIGSLTI 512
Query: 520 NNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVG-LSVHVVAVMLY 578
N ER++ ++FS PF G++++V + + +F++P+ +W+++ + + VVA+ ++
Sbjct: 513 NEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVF 572
Query: 579 LLDRFSP--FGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVW 636
+ + FSP + + ++ A T+ ++W W ++ N+ + PR +++I+ +VW
Sbjct: 573 MFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVW 632
Query: 637 AGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDK---FIYATVKQSSVDIYF 693
A FA+I +ASYTANLAAF++ ++ + ++G++D + + P D+ F + TV S +
Sbjct: 633 AFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNI 692
Query: 694 RRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--T 749
R M+ HM K N S +A+ +++ KL AFI+D+AVL + A + C LVT +
Sbjct: 693 RSNYR--DMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGS 750
Query: 750 GELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APAT 807
G++F +G+GI M+KDS WK+ + L++L+ +G + L+ W+ C + N +
Sbjct: 751 GKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLS-GICQNEKNEVMSSK 809
Query: 808 LTFENMAGVF--MLVAGGIVAGIFLIFIEIAYK-RHKDARRKQMQLAFAAVNVWRKNLQD 864
L +NMAGVF +LVA G+ +F + +K RH Q+ A + + +
Sbjct: 810 LDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLA----FSRGIYS 865
Query: 865 RKSG---RAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGG 905
SG A P P++ + +S AS K ++++D T G
Sbjct: 866 CFSGVQSLASP-PRQASPDLTASSAQASVLKMLQAARDMVTTAG 908
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 265 bits (677), Expect = 1e-70
Identities = 242/953 (25%), Positives = 436/953 (45%), Gaps = 131/953 (13%)
Query: 10 ALLFSCSVARAACDPKIVNIGAVLSTRKHEQM------FREAVNQANKRHGSWKIQLNAT 63
ALL+ P+++ IG + T ++E + F+ AV N+ + + T
Sbjct: 20 ALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN----RTLMPNT 75
Query: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
++T+ I + S + A+ V+ P+ + + V +P + T
Sbjct: 76 TLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVP--HIQT 133
Query: 124 RMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETL 183
R S + L ++ P Y+ S +++ Y+W + ++ D RL+ L
Sbjct: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS----TGLIRLQEL 189
Query: 184 LE--ERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMT 241
++ R + K+ Q G K+ LL E K+ + +I S + AA + + + M
Sbjct: 190 IKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMM 249
Query: 242 GSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKN---------------------- 276
Y + ++ L RY+ + G +L+N N
Sbjct: 250 TEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309
Query: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
E+A + DAV +VA A H + +T C + W+ GP F ++
Sbjct: 310 TGLLDGMMTTEAALMYDAVYMVAIASHRASQ---LTVSSLQCHRHKP-WRLGPRFMNLIK 365
Query: 327 SSKYADGVTGRVEFNE-DGDRKFANYSIMNLQNRKLVQVGIYN---GTHVIPNDRKIIWP 382
+++ DG+TG + FN+ +G RK + I++L+ ++GI+N G ++ +++
Sbjct: 366 EARW-DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKD---- 420
Query: 383 GGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDT 442
++ + L + TI +EP+V + K + + G ND
Sbjct: 421 --KSSNITDSLANRTLIVTTILEEPYVMYR--------KSDKPLYG-----------NDR 459
Query: 443 SPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMM 502
G +C+DLL +L+ + F Y+V LV DGK+G Q ++K EWNGM+
Sbjct: 460 FEG------------YCLDLLKELSNILGFIYDVKLVPDGKYGAQ-----NDKGEWNGMV 502
Query: 503 GELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST---LDSFMQPFQ 559
EL+ +AD+ VAPLTI R + I+FSKPF G++IL +K P T + SF+ P
Sbjct: 503 KELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK--PNGTNPGVFSFLNPLS 560
Query: 560 STLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL----TLSSAMWFSWGVLL 615
+W+ V L+ V+ +L+++ RF+P+ + + + D + TL ++ WF G L+
Sbjct: 561 PDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALM 620
Query: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
G E P++ S RI+G +W F +II++SYTANLAAFL ++R E I +D +
Sbjct: 621 QQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT- 678
Query: 676 SDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN----YESAAEAIQAVRDNKLHA 728
K Y V+ S +F++ ++ST M+ M ++ E IQ V +A
Sbjct: 679 --KIEYGAVRDGSTMTFFKKS-KISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTD-YA 734
Query: 729 FIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDL 788
+ +S +E+ + C+L G L G+G+G SP++ ++++IL+ E G + +
Sbjct: 735 LLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMM 794
Query: 789 DKTWVRYQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ 847
+ W R C N A+ L EN+ G+F+++A G+V +F+ E YK K+ +Q
Sbjct: 795 KEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQ 854
Query: 848 MQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
A + +L+++K + + K K++F +++ + +RR K+T
Sbjct: 855 CLSFNAIMEELGISLKNQKKIKKKSRTKGKSSF----TSILTCHQRRTQRKET 903
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 263 bits (672), Expect = 6e-70
Identities = 196/725 (27%), Positives = 356/725 (49%), Gaps = 52/725 (7%)
Query: 136 SFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEK-- 193
+FL+ Q V FE++ Y W + + + RA +E L + E
Sbjct: 160 TFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRG 219
Query: 194 VLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGERE 253
L DPG L + + + A++ +L + ++A V+RAA +TGSGYVW + +
Sbjct: 220 ALTLDPGAGEAV-LSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQ 278
Query: 254 ISGNALRYAPD-------------GILGLQLINGKNESAH-ISDAVGVVAQAVHELLEKE 299
++G AP G+ ++ +++ A ++ V VVA+ LL
Sbjct: 279 LAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDY 338
Query: 300 NITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNR 359
N G R M+ + + FNEDG + +++L
Sbjct: 339 GFLPELGHDCRAQNRTHRGESLHRYFMNITWDNR---DYSFNEDGFLVNPSLVVISLTRD 395
Query: 360 KLVQVGIYNGTHVIPNDRKIIWPG-GETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLS-D 417
+ +V + + + +W G +P + L + T+ + PFV V+P
Sbjct: 396 RTWEV-VGSWEQQTLRLKYPLWSRYGRFLQP--VDDTQHLTVATLEERPFVIVEPADPIS 452
Query: 418 GTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVH 477
GTC + + + + P +PR +CC GFCID+L +LA T+ F+Y+++
Sbjct: 453 GTCIRDSVPCRSQLNRT-----HSPPPDAPRPE-KRCCKGFCIDILKRLAHTIGFSYDLY 506
Query: 478 LVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQG 537
LV +GK G ++++ WNGM+GE+ +ADM + LTIN ER++ ++FS PF G
Sbjct: 507 LVTNGKHG--KKIDGV----WNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETG 560
Query: 538 LTILVKKEIPRSTLDSFMQPFQSTLWLLVG-LSVHVVAVMLYLLDRFSPFG--RFKVNSE 594
++++V + + +F++P+ +W+++ + + VVAV +++ + SP G R +
Sbjct: 561 ISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGK 620
Query: 595 EEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAF 654
T+ ++W W ++ N+ + PR +++I+ +VWA FA+I +ASYTANLAAF
Sbjct: 621 RPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAF 680
Query: 655 LVLDRPEERITGINDPRLRNPSDKF---IYATVKQSSVDIYFRRQVELSTMYRHMEKHNY 711
++ + + ++G++D + + P +++ + TV S + R M+ +M ++N
Sbjct: 681 MIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRS--NYPDMHSYMVRYNQ 738
Query: 712 ESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFRSGFGIGMRKDSP 767
EA+ ++ KL AFI+D+AVL + A + C LVT +G++F +G+GI + K S
Sbjct: 739 PRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSR 798
Query: 768 WKQNVSLSILKSHENGFMEDLDKTWVR-YQECDSRSNAPATLTFENMAGVF--MLVAGGI 824
WK+ + L++L+ + +E L++ W+ D + L +NMAGVF +LVA G+
Sbjct: 799 WKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGL 858
Query: 825 VAGIF 829
+F
Sbjct: 859 SLLVF 863
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 258 bits (660), Expect = 1e-68
Identities = 231/895 (25%), Positives = 410/895 (45%), Gaps = 130/895 (14%)
Query: 39 EQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM-----ALSVCEDLISSQVYAILVS 93
E FR AVN N+ + L T++T+ I + A D +S V AI
Sbjct: 54 ELAFRFAVNTINRN----RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIF-- 107
Query: 94 HPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE 153
P+ + V +P + + + +K ++ P +S S +
Sbjct: 108 ---GPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSSLSRAILD 162
Query: 154 MMRVYSWNHIILLVSDDHEGRAAQKRLETLLE--ERESKAEKVLQFDPGTKNVTALLMEA 211
+++ + W + +V DD G RL+ L++ R + K+ Q TK+ LL E
Sbjct: 163 LVQFFKWK-TVTVVYDDSTGLI---RLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM 218
Query: 212 KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG---NALRYAPDGILG 268
K + +I S + AA + + A + M Y ++ ++ RY+ + G
Sbjct: 219 KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278
Query: 269 LQLINGKN--------------------------------ESAHISDAVGVVAQAVHELL 296
+++N +N ++A + DAV VV+ AV +
Sbjct: 279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFP 338
Query: 297 EKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNE-DGDRKFANYSIMN 355
+ +T C W+ G F ++ + + +G+TGR+ FN+ +G R + +++
Sbjct: 339 Q---MTVSSLQC-NRHKPWRFGTRFMSLIKEAHW-EGLTGRITFNKTNGLRTDFDLDVIS 393
Query: 356 LQNRKLVQVGIYN---GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVK 412
L+ L ++G ++ G ++ + + G+ + L + TI +EP+V K
Sbjct: 394 LKEEGLEKIGTWDPASGLNMTESQK------GKPANITDSLSNRSLIVTTILEEPYVLFK 447
Query: 413 PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNF 472
K + + G ND G +CIDLL +L+ + F
Sbjct: 448 --------KSDKPLYG-----------NDRFEG------------YCIDLLRELSTILGF 476
Query: 473 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP 532
TYE+ LV DGK+G Q+ N +WNGM+ EL+ +AD+ VAPL I R + I+FSKP
Sbjct: 477 TYEIRLVEDGKYGAQDDANG----QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
Query: 533 FKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRF 589
F G++IL +K P T + SF+ P +W+ + L+ V+ +L+++ RFSP+ +
Sbjct: 533 FMTLGISILYRK--PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY 590
Query: 590 KVNSEEEEEDAL----TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVA 645
+ + D + TL ++ WF G L+ G E P++ S RI+G +W F +II++
Sbjct: 591 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIIS 649
Query: 646 SYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---M 702
SYTANLAAFL ++R E I +D + K Y V+ + +F++ ++ST M
Sbjct: 650 SYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVEDGATMTFFKKS-KISTYDKM 705
Query: 703 YRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGF 758
+ M +S E IQ V + +AF+ +S +EF + C+L G L G+
Sbjct: 706 WAFMSSRRQSVLVKSNEEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGY 764
Query: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC-DSRSNAPATLTFENMAGVF 817
G+G SP++ ++++IL+ E G + + + W R C + S + L +N+ G+F
Sbjct: 765 GVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIF 824
Query: 818 MLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEP 872
+++A G+V +F+ E YK K+A+ ++ A V R +L+ ++ + +P
Sbjct: 825 IVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKP 879
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 255 bits (651), Expect = 2e-67
Identities = 233/904 (25%), Positives = 408/904 (45%), Gaps = 130/904 (14%)
Query: 10 ALLFSCSVARAACDPKIVNIGAVLSTRKHEQM------FREAVNQANKRHGSWKIQLNAT 63
ALL+ P+++ IG + T ++E + F+ AV N+ + + T
Sbjct: 20 ALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN----RTLMPNT 75
Query: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
++T+ I + S + A+ V+ P+ + + V +P + T
Sbjct: 76 TLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVP--HIQT 133
Query: 124 RMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETL 183
R S + L ++ P Y+ S +++ Y+W + ++ D RL+ L
Sbjct: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS----TGLIRLQEL 189
Query: 184 LE--ERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMT 241
++ R + K+ Q G K+ LL E K+ + +I S + AA + + + M
Sbjct: 190 IKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMM 249
Query: 242 GSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKN---------------------- 276
Y + ++ L RY+ + G +L+N N
Sbjct: 250 TEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309
Query: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
E+A + DAV +VA A H + +T C + W+ GP F ++
Sbjct: 310 TGLLDGMMTTEAALMYDAVYMVAIASHRASQ---LTVSSLQCHRHKP-WRLGPRFMNLIK 365
Query: 327 SSKYADGVTGRVEFNE-DGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKI-IWPGG 384
+++ DG+TG + FN+ +G RK + I++L+ + H+ +KI IW
Sbjct: 366 EARW-DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSN 424
Query: 385 ------ETEKPRGYQMSTRLK-----IVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKK 433
++ K + ++ L + TI +EP+V + K + + G
Sbjct: 425 SGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYR--------KSDKPLYG----- 471
Query: 434 VICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNS 493
ND G +C+DLL +L+ + F Y+V LV DGK+G Q +
Sbjct: 472 ------NDRFEG------------YCLDLLKELSNILGFIYDVKLVPDGKYGAQ-----N 508
Query: 494 NKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST--- 550
+K EWNGM+ EL+ +AD+ VAPLTI R + I+FSKPF G++IL +K P T
Sbjct: 509 DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK--PNGTNPG 566
Query: 551 LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL----TLSSA 606
+ SF+ P +W+ V L+ V+ +L+++ RF+P+ + + + D + TL ++
Sbjct: 567 VFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNS 626
Query: 607 MWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITG 666
WF G L+ G E P++ S RI+G +W F +II++SYTANLAAFL ++R E I
Sbjct: 627 FWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 685
Query: 667 INDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN----YESAAEAIQ 719
+D + K Y V+ S +F++ ++ST M+ M ++ E IQ
Sbjct: 686 ADDLAKQT---KIEYGAVRDGSTMTFFKKS-KISTYEKMWAFMSSRQQTALVRNSDEGIQ 741
Query: 720 AVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKS 779
V +A + +S +E+ + C+L G L G+G+G SP++ ++++IL+
Sbjct: 742 RVLTTD-YALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQL 800
Query: 780 HENGFMEDLDKTWVRYQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYK 838
E G + + + W R C N A+ L EN+ G+F+++A G+V +F+ E YK
Sbjct: 801 QEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYK 860
Query: 839 RHKD 842
K+
Sbjct: 861 SRKN 864
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 253 bits (647), Expect = 4e-67
Identities = 226/867 (26%), Positives = 397/867 (45%), Gaps = 130/867 (14%)
Query: 39 EQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM-----ALSVCEDLISSQVYAILVS 93
E FR AVN N+ + L T++T+ I + A D +S V AI
Sbjct: 54 ELAFRFAVNTINRN----RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIF-- 107
Query: 94 HPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE 153
P+ + V +P + + + +K ++ P +S S +
Sbjct: 108 ---GPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSSLSRAILD 162
Query: 154 MMRVYSWNHIILLVSDDHEGRAAQKRLETLLE--ERESKAEKVLQFDPGTKNVTALLMEA 211
+++ + W + +V DD G RL+ L++ R + K+ Q TK+ LL E
Sbjct: 163 LVQFFKWK-TVTVVYDDSTGLI---RLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM 218
Query: 212 KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG---NALRYAPDGILG 268
K + +I S + AA + + A + M Y ++ ++ RY+ + G
Sbjct: 219 KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278
Query: 269 LQLINGKN--------------------------------ESAHISDAVGVVAQAVHELL 296
+++N +N ++A + DAV VV+ AV +
Sbjct: 279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFP 338
Query: 297 EKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNE-DGDRKFANYSIMN 355
+ +T C W+ G F ++ + + +G+TGR+ FN+ +G R + +++
Sbjct: 339 Q---MTVSSLQC-NRHKPWRFGTRFMSLIKEAHW-EGLTGRITFNKTNGLRTDFDLDVIS 393
Query: 356 LQNRKLVQVGIYN---GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVK 412
L+ L ++G ++ G ++ + + G+ + L + TI +EP+V K
Sbjct: 394 LKEEGLEKIGTWDPASGLNMTESQK------GKPANITDSLSNRSLIVTTILEEPYVLFK 447
Query: 413 PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNF 472
K + + G ND G +CIDLL +L+ + F
Sbjct: 448 --------KSDKPLYG-----------NDRFEG------------YCIDLLRELSTILGF 476
Query: 473 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP 532
TYE+ LV DGK+G Q+ N +WNGM+ EL+ +AD+ VAPL I R + I+FSKP
Sbjct: 477 TYEIRLVEDGKYGAQDDANG----QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
Query: 533 FKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRF 589
F G++IL +K P T + SF+ P +W+ + L+ V+ +L+++ RFSP+ +
Sbjct: 533 FMTLGISILYRK--PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY 590
Query: 590 KVNSEEEEEDAL----TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVA 645
+ + D + TL ++ WF G L+ G E P++ S RI+G +W F +II++
Sbjct: 591 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIIS 649
Query: 646 SYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---M 702
SYTANLAAFL ++R E I +D + K Y V+ + +F++ ++ST M
Sbjct: 650 SYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVEDGATMTFFKKS-KISTYDKM 705
Query: 703 YRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGF 758
+ M +S E IQ V + +AF+ +S +EF + C+L G L G+
Sbjct: 706 WAFMSSRRQSVLVKSNEEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGY 764
Query: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC-DSRSNAPATLTFENMAGVF 817
G+G SP++ ++++IL+ E G + + + W R C + S + L +N+ G+F
Sbjct: 765 GVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIF 824
Query: 818 MLVAGGIVAGIFLIFIEIAYKRHKDAR 844
+++A G+V +F+ E YK K+A+
Sbjct: 825 IVLAAGLVLSVFVAVGEFLYKSKKNAQ 851
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
3A [Homo sapiens]
Length = 1115
Score = 252 bits (643), Expect = 1e-66
Identities = 191/668 (28%), Positives = 332/668 (49%), Gaps = 71/668 (10%)
Query: 199 PGTKNVTALLM----EAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREI 254
P T+++ + L K V++ + ++ + W++G+
Sbjct: 302 PSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGD--- 358
Query: 255 SGNALRYAPDGI-LGLQLINGKNESA----HISDAVGVVAQAVHE--LLEKENITDPPR- 306
S N +G+ LGL + +GK + ++ DA+ +VA+AV +++ E P
Sbjct: 359 SQNVEELRTEGLPLGL-IAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTM 417
Query: 307 GC--VGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFAN-YSIMNLQNRKL-- 361
C V TN+ +G R L ++ + G++G + N + I NLQ+ +
Sbjct: 418 NCMEVETTNL-TSGQYLSRFLANTTFR-GLSGSIRVKGSTIVSSENNFFIWNLQHDPMGK 475
Query: 362 ---VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRL--KIVTIHQEPFVYVKPTLS 416
++G + G ++ + IWP +Q ++L ++VT+ + PFV+ +
Sbjct: 476 PMWTRLGSWQGGKIVMDYG--IWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDD 533
Query: 417 DGTCKEEFTVNGDPVKKVICTGP--NDTSP--------GSPRHTVP----QCCYGFCIDL 462
+G C P + +C P ND+S S TVP +CCYG+CIDL
Sbjct: 534 EGLC---------PAGQ-LCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDL 583
Query: 463 LIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNE 522
L K+A MNF +++++V DGK+G + + W G++G+LL G A M V +IN
Sbjct: 584 LEKIAEDMNFDFDLYIVGDGKYGAWKNGH------WTGLVGDLLRGTAHMAVTSFSINTA 637
Query: 523 RAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDR 582
R+Q I+F+ PF L ILV+ + + +FM P T+WL + +++H+ AV L L +
Sbjct: 638 RSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEW 697
Query: 583 FSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
SPFG + SSA+ + +L + P+ ++ R L +WA F M
Sbjct: 698 KSPFG--LTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMF 755
Query: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTM 702
+++YTANLAA +V ++ E ++GI+DP+L +PS F + TV++SS + Y R+ M
Sbjct: 756 CLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ--SFPEM 813
Query: 703 YRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEAS--QKCDLVTTGELFFRSGF 758
+ +M ++N + + ++ ++++ KL AFI D A+L++E S C L+T G+ F G+
Sbjct: 814 HEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGY 873
Query: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNA---PATLTFENMAG 815
GIG+ +SP N+S I + +GFM+ L W R C RS A + ++ +G
Sbjct: 874 GIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSG 933
Query: 816 VFMLVAGG 823
+F+L+ G
Sbjct: 934 LFVLLCIG 941
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 251 bits (641), Expect = 2e-66
Identities = 206/752 (27%), Positives = 335/752 (44%), Gaps = 92/752 (12%)
Query: 201 TKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLV----------- 249
+++ T LL E ++ + II+ A+ + + R A+ L MT + Y +++
Sbjct: 196 SRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLD 255
Query: 250 GEREISGNALRYA---------PDGILGLQLINGKN-----------ESAHISDAVGVVA 289
G E S N L ++ P+ + L + +N +A + DAV VV
Sbjct: 256 GIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVV 315
Query: 290 QAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFA 349
AV EL + I P C + NIW G L +Y DG+TGRVEFN G R
Sbjct: 316 SAVRELNRSQEIGVKPLACT-SANIWPHGTSLMNYLRMVEY-DGLTGRVEFNSKGQRTNY 373
Query: 350 NYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFV 409
I+ + ++G++ + + + + + T L + TI + P+V
Sbjct: 374 TLRILEKSRQGHREIGVWYSNRTLAMNATTL----DINLSQTLANKT-LVVTTILENPYV 428
Query: 410 YVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLART 469
+P + E F GFC+D+L +LA
Sbjct: 429 MRRPNFQALSGNERFE-------------------------------GFCVDMLRELAEL 457
Query: 470 MNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEF 529
+ F Y + LV DG +G E N S W GM+GEL++ +AD+ VA TI ER + I+F
Sbjct: 458 LRFRYRLRLVEDGLYGAPEP-NGS----WTGMVGELINRKADLAVAAFTITAEREKVIDF 512
Query: 530 SKPFKYQGLTILVKKEIPRST-LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGR 588
SKPF G++IL + + R SF+ PF +WL + L+ V+ +L+L R SP+
Sbjct: 513 SKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW 572
Query: 589 FKVN-----SEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMII 643
+ + E+ TL +++WF G + G E PR+ S R + VW F +II
Sbjct: 573 YNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQG-SEIMPRALSTRCVSGVWWAFTLII 631
Query: 644 VASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFR--RQVELST 701
++SYTANLAAFL + R E + +D Y T+ S +F+ R
Sbjct: 632 ISSYTANLAAFLTVQRMEVPVESADD---LADQTNIEYGTIHAGSTMTFFQNSRYQTYQR 688
Query: 702 MYRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSG 757
M+ +M+ +S E I V N +AF+ +S + E+ C+L G L G
Sbjct: 689 MWNYMQSKQPSVFVKSTEEGIARVL-NSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKG 747
Query: 758 FGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPAT-LTFENMAGV 816
+GIGM SP++ ++L+IL+ EN +E L + W C + A L EN+ G+
Sbjct: 748 YGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGI 807
Query: 817 FMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKK 876
F+++ G++ +F+ +E + + A +++ + + R + RK+ R+ +
Sbjct: 808 FIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRP 867
Query: 877 KATFRAITSTLASSFKRRRSSKDTSTGGGRGA 908
RA+ S A R + K S G G A
Sbjct: 868 GGPSRALLSLRAVREMRLSNGKLYSAGAGGDA 899
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 248 bits (633), Expect = 2e-65
Identities = 220/821 (26%), Positives = 376/821 (45%), Gaps = 119/821 (14%)
Query: 137 FLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQ 196
++ P Y+ S ++++ W + V DD G + L + R + K+ Q
Sbjct: 149 YVNLYPDYASLSHAILDLVQYLKWRSATV-VYDDSTGLIRLQEL-IMAPSRYNIRLKIRQ 206
Query: 197 FDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG 256
+ + LL E K II S AA + + A + M Y ++ ++
Sbjct: 207 LPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYA 266
Query: 257 NAL---RYAPDGILGLQLINGKNESAHIS--------DAVGVVAQAVHELLEKENITDP- 304
L RY+ + G +++N N H+S + + ++ LL+ +TD
Sbjct: 267 LDLEPYRYSGVNLTGFRILNVDNP--HVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAA 324
Query: 305 ----------------PRGCVGNTNI-----WKTGPLFKRVLMSSKYADGVTGRVEFNE- 342
P+ V + W+ G F + +++ +G+TGR+ FN+
Sbjct: 325 LLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQW-EGLTGRIVFNKT 383
Query: 343 DGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLK--- 399
G R + I++L+ L +VG+++ P D I E K RG ++ L
Sbjct: 384 SGLRTDFDLDIISLKEDGLEKVGVWS-----PADGLNIT---EVAKGRGPNVTDSLTNRS 435
Query: 400 --IVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYG 457
+ T+ +EPFV + K + T+ G ND G
Sbjct: 436 LIVTTVLEEPFVMFR--------KSDRTLYG-----------NDRFEG------------ 464
Query: 458 FCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPL 517
+CIDLL +LA + F+YE+ LV DGK+G Q+ +K +WNGM+ EL+ +AD+ VAPL
Sbjct: 465 YCIDLLKELAHILGFSYEIRLVEDGKYGAQD-----DKGQWNGMVKELIDHKADLAVAPL 519
Query: 518 TINNERAQYIEFSKPFKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVA 574
TI + R + I+FSKPF G++IL +K P T + SF+ P +W+ V L+ V+
Sbjct: 520 TITHVREKAIDFSKPFMTLGVSILYRK--PNGTNPSVFSFLNPLSPDIWMYVLLAYLGVS 577
Query: 575 VMLYLLDRFSPFGRFKVN----SEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSAR 630
+L+++ RFSP+ + + E E+ TL ++ WF G L+ G E P++ S R
Sbjct: 578 CVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQG-SELMPKALSTR 636
Query: 631 ILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVD 690
I+G +W F +II++SYTANLAAFL ++R E I +D + K Y VK +
Sbjct: 637 IIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVKDGATM 693
Query: 691 IYFRRQVELST---MYRHME-------KHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA 740
+F++ ++ST M+ M K+N E A+ A +A + +S +E+
Sbjct: 694 TFFKKS-KISTFEKMWAFMSSKPSALVKNNEEGIQRALTAD-----YALLMESTTIEYVT 747
Query: 741 SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDS 800
+ C+L G L G+GIG SP++ ++++IL+ E + + + W R C
Sbjct: 748 QRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPE 807
Query: 801 RSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWR 859
N A+ L + + G+F+++A G+V + + E YK K A R+Q + R
Sbjct: 808 EENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIR 867
Query: 860 KNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
+L ++ + +P P A+ + + + RR KD+
Sbjct: 868 FSLTCQRRVKHKPQPPMMVKTDAVIN-MHTFNDRRLPGKDS 907
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 244 bits (624), Expect = 2e-64
Identities = 197/751 (26%), Positives = 350/751 (46%), Gaps = 115/751 (15%)
Query: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEER-ESKAEKVLQFDPGTKNVTALLMEAKELEA 216
Y W + + D QK L+T E+ + A +L + L + ++ +
Sbjct: 140 YKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTE--EGYRMLFQDLEKKKE 197
Query: 217 RVIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLIN 273
R++++ + + L G GY +++ G +I N + + + G QL+N
Sbjct: 198 RLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVN 257
Query: 274 ----------------------------GKNESAHISDAVGVVAQAVHELLEKENITDPP 305
K SA D V V+A+A L ++ I
Sbjct: 258 YTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSL-RRQRIDISR 316
Query: 306 RG----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
RG C+ N + W G +R L ++ +G+TG V+FNE G R ++ +++
Sbjct: 317 RGNAGDCLANPAVPWGQGIDIQRALQQVRF-EGLTGNVQFNEKGRRTNYTLHVIEMKHDG 375
Query: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLK---IVTIHQEPFVYVKPTLSD 417
+ ++G +N D K + P + G S + + + TI ++P+V +K +
Sbjct: 376 IRKIGYWN------EDDKFV-PAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQ 428
Query: 418 GTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVH 477
G+ R+ G+C++L ++A+ + ++Y +
Sbjct: 429 -------------------------FEGNDRYE------GYCVELAAEIAKHVGYSYRLE 457
Query: 478 LVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQG 537
+V+DGK+G ++ + K WNGM+GEL+ G+AD+ VAPLTI R + I+FSKPF G
Sbjct: 458 IVSDGKYGARD----PDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLG 513
Query: 538 LTILVKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPF---------G 587
++I++KK + + + SF+ P +W+ + + V+V+L+L+ RFSP+ G
Sbjct: 514 ISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEG 573
Query: 588 RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASY 647
R + S++ E + +++WFS G + G + +PRS S RI+G VW F +II++SY
Sbjct: 574 RDQTTSDQSNE--FGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSY 630
Query: 648 TANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRH 705
TANLAAFL ++R I D + + Y T++ S +FRR M+ +
Sbjct: 631 TANLAAFLTVERMVSPIESAEDLAKQT---EIAYGTLEAGSTKEFFRRSKIAVFEKMWTY 687
Query: 706 MEKHN----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFG 759
M+ + E + VR +K +A++ +S + E+ E + CD + G G+G
Sbjct: 688 MKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG 747
Query: 760 IGMRKDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDS----RSNAPATLTFENMA 814
I K S + V+L++LK +E G ++ L +K W EC S + + L+ N+A
Sbjct: 748 IATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVA 807
Query: 815 GVFMLVAGGIVAGIFLIFIEIAYKRHKDARR 845
GVF ++ GG+ + + IE YK +++R
Sbjct: 808 GVFYILIGGLGLAMLVALIEFCYKSRSESKR 838
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 244 bits (622), Expect = 4e-64
Identities = 197/751 (26%), Positives = 349/751 (46%), Gaps = 115/751 (15%)
Query: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEER-ESKAEKVLQFDPGTKNVTALLMEAKELEA 216
Y W + + D QK L+T E+ + A +L + L + ++ +
Sbjct: 140 YKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTE--EGYRMLFQDLEKKKE 197
Query: 217 RVIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLIN 273
R++++ + + L G GY +++ G +I N + + + G QL+N
Sbjct: 198 RLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVN 257
Query: 274 ----------------------------GKNESAHISDAVGVVAQAVHELLEKENITDPP 305
K SA D V V+A+A L ++ I
Sbjct: 258 YTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSL-RRQRIDISR 316
Query: 306 RG----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
RG C+ N + W G +R L ++ +G+TG V+FNE G R ++ +++
Sbjct: 317 RGNAGDCLANPAVPWGQGIDIQRALQQVRF-EGLTGNVQFNEKGRRTNYTLHVIEMKHDG 375
Query: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLK---IVTIHQEPFVYVKPTLSD 417
+ ++G +N D K + P + G S + + + TI ++P+V +K +
Sbjct: 376 IRKIGYWN------EDDKFV-PAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQ 428
Query: 418 GTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVH 477
G+ R+ G+C++L ++A+ + ++Y +
Sbjct: 429 -------------------------FEGNDRYE------GYCVELAAEIAKHVGYSYRLE 457
Query: 478 LVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQG 537
+V+DGK+G ++ + K WNGM+GEL+ G+AD+ VAPLTI R + I+FSKPF G
Sbjct: 458 IVSDGKYGARD----PDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLG 513
Query: 538 LTILVKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPF---------G 587
++I++KK + + + SF+ P +W+ + + V+V+L+L+ RFSP+ G
Sbjct: 514 ISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEG 573
Query: 588 RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASY 647
R + S++ E + +++WFS G + G + +PRS S RI+G VW F +II++SY
Sbjct: 574 RDQTTSDQSNE--FGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSY 630
Query: 648 TANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRH 705
TANLAAFL ++R I D + + Y T++ S +FRR M+ +
Sbjct: 631 TANLAAFLTVERMVSPIESAEDLAKQT---EIAYGTLEAGSTKEFFRRSKIAVFEKMWTY 687
Query: 706 MEKHN----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFG 759
M+ + E + VR +K +A++ +S + E+ E + CD + G G+G
Sbjct: 688 MKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG 747
Query: 760 IGMRKDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNA----PATLTFENMA 814
I K S + V+L++LK E G ++ L K W EC S+ + + L+ N+A
Sbjct: 748 IATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVA 807
Query: 815 GVFMLVAGGIVAGIFLIFIEIAYKRHKDARR 845
GVF ++ GG+ + + IE YK +++R
Sbjct: 808 GVFYILIGGLGLAMLVALIEFCYKSRSESKR 838
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 243 bits (621), Expect = 5e-64
Identities = 198/728 (27%), Positives = 342/728 (46%), Gaps = 71/728 (9%)
Query: 231 VYRAAAMLNMTGSGYVWLVGEREISGNALRYA--PDGILGLQLINGKNESAHISDAVGVV 288
+ RA +L G WL+G + AL A P G+L L + A I D V +V
Sbjct: 242 IARARRVLEAVPPGPHWLLGT-PLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLV 300
Query: 289 AQAVHELLE---KENITDPPRGCVGNTNIWKTGP-----LFKRVLMSSKYADGVTGRVEF 340
A+A+ + K + P C ++ GP R L ++ + G TG V
Sbjct: 301 ARALGSAAQVQPKRALLPAPVNC---GDLQPAGPESPGRFLARFLANTSF-QGRTGPVWV 356
Query: 341 NEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP---RGYQMSTR 397
+ + + R + + + + PGG + +P +G Q+ +
Sbjct: 357 TGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPK 416
Query: 398 LKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSP----------GSP 447
L++VT+ + PFV+ + DG C + + G ND++ GS
Sbjct: 417 LRVVTLLEHPFVFARDPDEDGQCPAG--------QLCLDPGTNDSATLDALFAALANGSA 468
Query: 448 RHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLS 507
+ +CCYG+CIDLL +LA F +E++LV DGK+G W G++G+LL+
Sbjct: 469 PRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALR------DGRWTGLVGDLLA 522
Query: 508 GQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVG 567
G+A M V +IN+ R+Q ++F+ PF L I+V+ S + +FM P + WL V
Sbjct: 523 GRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVF 582
Query: 568 LSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSF 627
++H+ A+ L + + SP+G + SSA+ + +L + P+
Sbjct: 583 AALHLTALFLTVYEWRSPYGL--TPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCP 640
Query: 628 SARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQS 687
+ R+L +WA F +++++SYTANLAA +V D+ E ++GI+DP+L +P+ F + TV +S
Sbjct: 641 TGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWES 700
Query: 688 SVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEAS--QK 743
S + Y ++ M+ HM +H+ + + + + KL+AFI D ++L++E S
Sbjct: 701 SAEAYIKK--SFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDAD 758
Query: 744 CDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN 803
C L+T G+ F G+GIG+ ++SP N+S I + +GF++ L W + C R
Sbjct: 759 CKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVF 818
Query: 804 A---PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDAR-RKQMQLAFAAVNVWR 859
A ++ + AG+F+L+ G+ + + E A+ R R RK +L + W
Sbjct: 819 AVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQY-----WL 873
Query: 860 KNLQ--DRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVL 917
Q R P+ K+ T A S ++++ + T+ G + A
Sbjct: 874 HTSQKIHRALNTEPPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKRA--------- 924
Query: 918 PRRAIERE 925
RRA+++E
Sbjct: 925 -RRAVDKE 931
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 241 bits (615), Expect = 2e-63
Identities = 224/927 (24%), Positives = 395/927 (42%), Gaps = 125/927 (13%)
Query: 11 LLFSCSVARAACDPKIVNIGAVLST--------RKHEQMFREAVNQANKRHGSWKIQLNA 62
+L + AC P + I A+L R + + +N+A +R G K++++
Sbjct: 9 VLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDI 68
Query: 63 TSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLT 122
+ + + + A ++C+ L V + S P + + +S G +P
Sbjct: 69 FELL-RDSEYETAETMCQILPKGVVAVLGPSSSPASS-----SIISNICGEKEVP----- 117
Query: 123 TRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEM-----MRVYSWNHIILLVSDDHEGRAAQ 177
+ ++ + F R H S+ + + ++ L+ + +
Sbjct: 118 -HFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLE 176
Query: 178 KRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAM 237
K L L +++ + ++L T++ T LL E ++ + II+ A+ + T+ AA
Sbjct: 177 KLLRQFLISKDTLSVRMLD---DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAE 233
Query: 238 LNMTGSGYVWLVGEREISGNALRYAPD---GILGLQLINGKN------------------ 276
L M + Y ++ E S + D ILG + N +
Sbjct: 234 LGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENC 293
Query: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
SA + DAV V AV EL + I P C G+ IW+ G L
Sbjct: 294 DHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSC-GSAQIWQHGTSLMNYLR 352
Query: 327 SSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGET 386
+ +G+TG +EFN G R I+ Q+G ++ + D +
Sbjct: 353 MVEL-EGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLY-----A 406
Query: 387 EKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGS 446
+T L + TI + P++ +K G + G+
Sbjct: 407 SNISDTLFNTTLVVTTILENPYLMLK-------------------------GNHQEMEGN 441
Query: 447 PRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELL 506
R+ GFC+D+L +LA + F Y++ LV DG +G E W GM+GEL+
Sbjct: 442 DRYE------GFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGT-----WTGMVGELI 490
Query: 507 SGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST-LDSFMQPFQSTLWLL 565
+ +AD+ VA LTI ER + I+FSKPF G++IL + + R SF+ PF +WL
Sbjct: 491 ARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLF 550
Query: 566 VGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEE-----DALTLSSAMWFSWGVLLNSGIG 620
+ L+ V+ +L+L+ R +P+ + + + + +L +++WF G + G
Sbjct: 551 MLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQG-S 609
Query: 621 EGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFI 680
APR+ S R + VW F +II++SYTANLAAFL + R + I ++D + +
Sbjct: 610 TIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIE--- 666
Query: 681 YATVKQSSVDIYFRR------QVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSA 734
Y T+ S +F+ Q + MY +S E I V N +AF+ +S
Sbjct: 667 YGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVL-NSNYAFLLEST 725
Query: 735 VLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVR 794
+ E+ + C+L G L G+GIGM S ++ L+IL+ EN +E L + W
Sbjct: 726 MNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE 785
Query: 795 YQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYK-RHKDARR----KQM 848
+C + A L EN+ G+F+++ G++ IF+ +E + RH +A ++M
Sbjct: 786 GGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEM 845
Query: 849 QLAFAAVNVWRKNLQDRKSGRAEPDPK 875
++ + + ++ R+ A P P+
Sbjct: 846 VTELRSIILCQDSIHPRRRRAAVPPPR 872
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 236 bits (602), Expect = 7e-62
Identities = 184/616 (29%), Positives = 307/616 (49%), Gaps = 87/616 (14%)
Query: 275 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 329
K SA DAV V+ +A L K+ I RG C+ N + W G +R L +
Sbjct: 294 KYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQ 352
Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 389
+G++G ++F+++G R +IM L+ ++G ++ D+ ++ TE P
Sbjct: 353 -VEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEV-----DKMVVTL---TELP 403
Query: 390 RGYQMS----TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPG 445
G S + + TI + P+V +K ++ G
Sbjct: 404 SGNDTSGLENKTVVVTTILESPYVMMKKN-------------------------HEMLEG 438
Query: 446 SPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGEL 505
+ R+ G+C+DL ++A+ F Y++ +V DGK+G ++ ++ K WNGM+GEL
Sbjct: 439 NERYE------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD----ADTKIWNGMVGEL 488
Query: 506 LSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWL 564
+ G+AD+ +APLTI R + I+FSKPF G++I++KK + + + SF+ P +W+
Sbjct: 489 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548
Query: 565 LVGLSVHVVAVMLYLLDRFSPF---------GRFKVNSEEEEEDALTLSSAMWFSWGVLL 615
+ + V+V+L+L+ RFSP+ GR +SE E + +++WFS G +
Sbjct: 549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNE--FGIFNSLWFSLGAFM 606
Query: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
G + +PRS S RI+G VW F +II++SYTANLAAFL ++R I D +
Sbjct: 607 RQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED---LSK 662
Query: 676 SDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHA 728
+ Y T+ S +FRR M+ +M + AE + VR +K +A
Sbjct: 663 QTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA 722
Query: 729 FIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMED 787
++ +S + E+ E + CD + G G+GI K S + V+L++LK +E G ++
Sbjct: 723 YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDK 782
Query: 788 L-DKTWVRYQEC-----DSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHK 841
L +K W EC DS+ A L+ N+AGVF ++ GG+ + + IE YK
Sbjct: 783 LKNKWWYDKGECGSGGGDSKEKTSA-LSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRA 841
Query: 842 DARRKQMQLAFAAVNV 857
+A+R M++A A N+
Sbjct: 842 EAKR--MKVAKNAQNI 855
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 235 bits (599), Expect = 2e-61
Identities = 181/615 (29%), Positives = 306/615 (49%), Gaps = 85/615 (13%)
Query: 275 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 329
K SA DAV V+ +A L K+ I RG C+ N + W G +R L +
Sbjct: 247 KYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQ 305
Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 389
+G++G ++F+++G R +IM L+ ++G ++ D+ ++ TE P
Sbjct: 306 -VEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEV-----DKMVVTL---TELP 356
Query: 390 RGYQMS----TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPG 445
G S + + TI + P+V +K ++ G
Sbjct: 357 SGNDTSGLENKTVVVTTILESPYVMMKKN-------------------------HEMLEG 391
Query: 446 SPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGEL 505
+ R+ G+C+DL ++A+ F Y++ +V DGK+G ++ ++ K WNGM+GEL
Sbjct: 392 NERYE------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD----ADTKIWNGMVGEL 441
Query: 506 LSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWL 564
+ G+AD+ +APLTI R + I+FSKPF G++I++KK + + + SF+ P +W+
Sbjct: 442 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 501
Query: 565 LVGLSVHVVAVMLYLLDRFSPF---------GRFKVNSEEEEEDALTLSSAMWFSWGVLL 615
+ + V+V+L+L+ RFSP+ GR +SE E + +++WFS G +
Sbjct: 502 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNE--FGIFNSLWFSLGAFM 559
Query: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
G + +PRS S RI+G VW F +II++SYTANLAAFL ++R I D +
Sbjct: 560 RQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED---LSK 615
Query: 676 SDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHA 728
+ Y T+ S +FRR M+ +M + AE + VR +K +A
Sbjct: 616 QTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA 675
Query: 729 FIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMED 787
++ +S + E+ E + CD + G G+GI K S + V+L++LK E G ++
Sbjct: 676 YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDK 735
Query: 788 L-DKTWVRYQECDSRSNA----PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKD 842
L +K W EC ++ + + L+ N+AGVF ++ GG+ + + IE YK +
Sbjct: 736 LKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAE 795
Query: 843 ARRKQMQLAFAAVNV 857
A+R M++A A N+
Sbjct: 796 AKR--MKVAKNAQNI 808
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 235 bits (599), Expect = 2e-61
Identities = 181/615 (29%), Positives = 306/615 (49%), Gaps = 85/615 (13%)
Query: 275 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 329
K SA DAV V+ +A L K+ I RG C+ N + W G +R L +
Sbjct: 294 KYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQ 352
Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 389
+G++G ++F+++G R +IM L+ ++G ++ D+ ++ TE P
Sbjct: 353 -VEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEV-----DKMVVTL---TELP 403
Query: 390 RGYQMS----TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPG 445
G S + + TI + P+V +K ++ G
Sbjct: 404 SGNDTSGLENKTVVVTTILESPYVMMKKN-------------------------HEMLEG 438
Query: 446 SPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGEL 505
+ R+ G+C+DL ++A+ F Y++ +V DGK+G ++ ++ K WNGM+GEL
Sbjct: 439 NERYE------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD----ADTKIWNGMVGEL 488
Query: 506 LSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWL 564
+ G+AD+ +APLTI R + I+FSKPF G++I++KK + + + SF+ P +W+
Sbjct: 489 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548
Query: 565 LVGLSVHVVAVMLYLLDRFSPF---------GRFKVNSEEEEEDALTLSSAMWFSWGVLL 615
+ + V+V+L+L+ RFSP+ GR +SE E + +++WFS G +
Sbjct: 549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNE--FGIFNSLWFSLGAFM 606
Query: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
G + +PRS S RI+G VW F +II++SYTANLAAFL ++R I D +
Sbjct: 607 RQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED---LSK 662
Query: 676 SDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHA 728
+ Y T+ S +FRR M+ +M + AE + VR +K +A
Sbjct: 663 QTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA 722
Query: 729 FIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMED 787
++ +S + E+ E + CD + G G+GI K S + V+L++LK E G ++
Sbjct: 723 YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDK 782
Query: 788 L-DKTWVRYQECDSRSNA----PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKD 842
L +K W EC ++ + + L+ N+AGVF ++ GG+ + + IE YK +
Sbjct: 783 LKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAE 842
Query: 843 ARRKQMQLAFAAVNV 857
A+R M++A A N+
Sbjct: 843 AKR--MKVAKNAQNI 855
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 223 bits (568), Expect = 6e-58
Identities = 182/750 (24%), Positives = 332/750 (44%), Gaps = 105/750 (14%)
Query: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEAR 217
Y W + L + Q +E ++ + + + ++ E + +
Sbjct: 156 YKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEK 215
Query: 218 VIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLING 274
++ + T+ +L GY +++ G +I + + I G Q++N
Sbjct: 216 RYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNN 275
Query: 275 KNE----------------------------SAHISDAVGVVAQAVHELLEKENITDPPR 306
+N SA DA+ V+A+A L ++ + R
Sbjct: 276 ENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFR-YLRRQRVDVSRR 334
Query: 307 G----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKL 361
G C+ N + W G +R L + G+TG ++F+ G R + ++
Sbjct: 335 GSAGDCLANPAVPWSQGIDIERALKMVQ-VQGMTGNIQFDTYGRRTNYTIDVYEMKVSGS 393
Query: 362 VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCK 421
+ G +N +R + + + + + + TI + P+V K
Sbjct: 394 RKAGYWN-----EYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKN------- 441
Query: 422 EEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVAD 481
++ G+ R+ G+C+DL ++A+ + Y++ +V D
Sbjct: 442 ------------------HEQLEGNERYE------GYCVDLAYEIAKHVRIKYKLSIVGD 477
Query: 482 GKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTIL 541
GK+G ++ K WNGM+GEL+ G+AD+ VAPLTI R + I+FSKPF G++I+
Sbjct: 478 GKYGARD----PETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIM 533
Query: 542 VKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
+KK + + + SF+ P +W+ + + V+V+L+L+ RFSP+ ++ EE D
Sbjct: 534 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP 593
Query: 601 LT---------LSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANL 651
+ + +++WFS G + G + +PRS S RI+G VW F +II++SYTANL
Sbjct: 594 QSPPDPPNEFGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANL 652
Query: 652 AAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKH 709
AAFL ++R I D + + Y T+ S +FRR M+ +M+
Sbjct: 653 AAFLTVERMVSPIESAEDLAKQT---EIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 709
Query: 710 N----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMR 763
++ A+ + VR +K AF+ +S + E+ E + CD + G G+G+
Sbjct: 710 EPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 769
Query: 764 KDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDS----RSNAPATLTFENMAGVFM 818
K S V+L++LK +E G ++ L +K W EC S + + L+ N+AGVF
Sbjct: 770 KGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFY 829
Query: 819 LVAGGIVAGIFLIFIEIAYKRHKDARRKQM 848
++ GG+ + + IE YK +++R ++
Sbjct: 830 ILVGGLGLAMMVALIEFCYKSRAESKRMKL 859
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 222 bits (566), Expect = 1e-57
Identities = 181/750 (24%), Positives = 332/750 (44%), Gaps = 105/750 (14%)
Query: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEAR 217
Y W + L + Q +E ++ + + + ++ E + +
Sbjct: 156 YKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEK 215
Query: 218 VIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLING 274
++ + T+ +L GY +++ G +I + + I G Q++N
Sbjct: 216 RYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNN 275
Query: 275 KNE----------------------------SAHISDAVGVVAQAVHELLEKENITDPPR 306
+N SA DA+ V+A+A L ++ + R
Sbjct: 276 ENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFR-YLRRQRVDVSRR 334
Query: 307 G----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKL 361
G C+ N + W G +R L + G+TG ++F+ G R + ++
Sbjct: 335 GSAGDCLANPAVPWSQGIDIERALKMVQ-VQGMTGNIQFDTYGRRTNYTIDVYEMKVSGS 393
Query: 362 VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCK 421
+ G +N +R + + + + + + TI + P+V K
Sbjct: 394 RKAGYWN-----EYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKN------- 441
Query: 422 EEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVAD 481
++ G+ R+ G+C+DL ++A+ + Y++ +V D
Sbjct: 442 ------------------HEQLEGNERYE------GYCVDLAYEIAKHVRIKYKLSIVGD 477
Query: 482 GKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTIL 541
GK+G ++ K WNGM+GEL+ G+AD+ VAPLTI R + I+FSKPF G++I+
Sbjct: 478 GKYGARD----PETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIM 533
Query: 542 VKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
+KK + + + SF+ P +W+ + + V+V+L+L+ RFSP+ ++ EE D
Sbjct: 534 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP 593
Query: 601 LT---------LSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANL 651
+ + +++WFS G + G + +PRS S RI+G VW F +II++SYTANL
Sbjct: 594 QSPPDPPNEFGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANL 652
Query: 652 AAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKH 709
AAFL ++R I D + + Y T+ S +FRR M+ +M+
Sbjct: 653 AAFLTVERMVSPIESAEDLAKQT---EIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 709
Query: 710 N----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMR 763
++ A+ + VR +K AF+ +S + E+ E + CD + G G+G+
Sbjct: 710 EPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 769
Query: 764 KDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNA----PATLTFENMAGVFM 818
K S V+L++LK E G ++ L +K W EC ++ + + L+ N+AGVF
Sbjct: 770 KGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFY 829
Query: 819 LVAGGIVAGIFLIFIEIAYKRHKDARRKQM 848
++ GG+ + + IE YK +++R ++
Sbjct: 830 ILVGGLGLAMMVALIEFCYKSRAESKRMKL 859
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 218 bits (556), Expect = 2e-56
Identities = 171/602 (28%), Positives = 290/602 (48%), Gaps = 75/602 (12%)
Query: 275 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 329
K SA D V V+A+ L ++ I RG C+ N W G +R L +
Sbjct: 295 KYTSALTYDGVLVMAETFRSL-RRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVR 353
Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 389
G+TG V+F+ G R + L++ +VG +N + + + G +T
Sbjct: 354 I-QGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAI 412
Query: 390 RGYQMSTRLKIVTIHQEPFVYVKPT--LSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSP 447
+ + + TI + P+V K + +G K E
Sbjct: 413 E----NRTVVVTTIMESPYVMYKKNHEMFEGNDKYE------------------------ 444
Query: 448 RHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLS 507
G+C+DL ++A+ + Y++ +V DGK+G ++ ++ K WNGM+GEL+
Sbjct: 445 ---------GYCVDLASEIAKHIGIKYKIAIVPDGKYGARD----ADTKIWNGMVGELVY 491
Query: 508 GQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWLLV 566
G+A++ +APLTI R + I+FSKPF G++I++KK + + + SF+ P +W+ +
Sbjct: 492 GKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI 551
Query: 567 GLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEE-------DALTLSSAMWFSWGVLLNSGI 619
+ V+V+L+L+ RFSP+ E+ +E + + +++WFS G + G
Sbjct: 552 VFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGC 611
Query: 620 GEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKF 679
+ +PRS S RI+G VW F +II++SYTANLAAFL ++R I D + +
Sbjct: 612 -DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQT---EI 667
Query: 680 IYATVKQSSVDIYFRRQ-----VELSTMYRHMEKHNY-ESAAEAIQAVRDNK-LHAFIWD 732
Y T+ S +FRR ++ T R E + + AE + VR +K AF+ +
Sbjct: 668 AYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLE 727
Query: 733 SAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDL-DK 790
S + E+ E + CD + G G+G+ K S V+L++LK +E G ++ L +K
Sbjct: 728 STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK 787
Query: 791 TWVRYQECDS----RSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRK 846
W EC S + + L+ N+AGVF ++ GG+ + + IE YK +A+R
Sbjct: 788 WWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRM 847
Query: 847 QM 848
++
Sbjct: 848 KV 849
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 218 bits (555), Expect = 2e-56
Identities = 185/641 (28%), Positives = 308/641 (48%), Gaps = 79/641 (12%)
Query: 275 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 329
K SA D V V+A+ L ++ I RG C+ N W G +R L +
Sbjct: 295 KYTSALTYDGVLVMAETFRSL-RRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVR 353
Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 389
G+TG V+F+ G R + L++ +VG +N + + + G +T
Sbjct: 354 I-QGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAI 412
Query: 390 RGYQMSTRLKIVTIHQEPFVYVKPT--LSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSP 447
+ + + TI + P+V K + +G K E
Sbjct: 413 E----NRTVVVTTIMESPYVMYKKNHEMFEGNDKYE------------------------ 444
Query: 448 RHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLS 507
G+C+DL ++A+ + Y++ +V DGK+G ++ ++ K WNGM+GEL+
Sbjct: 445 ---------GYCVDLASEIAKHIGIKYKIAIVPDGKYGARD----ADTKIWNGMVGELVY 491
Query: 508 GQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWLLV 566
G+A++ +APLTI R + I+FSKPF G++I++KK + + + SF+ P +W+ +
Sbjct: 492 GKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI 551
Query: 567 GLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEE-------DALTLSSAMWFSWGVLLNSGI 619
+ V+V+L+L+ RFSP+ E+ +E + + +++WFS G + G
Sbjct: 552 VFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGC 611
Query: 620 GEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKF 679
+ +PRS S RI+G VW F +II++SYTANLAAFL ++R I D + +
Sbjct: 612 -DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQT---EI 667
Query: 680 IYATVKQSSVDIYFRRQ-----VELSTMYRHMEKHNY-ESAAEAIQAVRDNK-LHAFIWD 732
Y T+ S +FRR ++ T R E + + AE + VR +K AF+ +
Sbjct: 668 AYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLE 727
Query: 733 SAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDL-DK 790
S + E+ E + CD + G G+G+ K S V+L++LK E G ++ L +K
Sbjct: 728 STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGTPVNLAVLKLSEAGVLDKLKNK 787
Query: 791 TWVRYQEC---DSRS-NAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRK 846
W EC DS S + + L+ N+AGVF ++ GG+ + + IE YK +A+R
Sbjct: 788 WWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRM 847
Query: 847 QMQLAFAAVNVWRKNLQDR--KSGRA-EPD-PKKKATFRAI 883
++ + A N R ++ ++GR PD PK T AI
Sbjct: 848 KLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAI 888
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 203 bits (517), Expect = 5e-52
Identities = 167/639 (26%), Positives = 291/639 (45%), Gaps = 89/639 (13%)
Query: 269 LQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPR-GCVG-NTNIWKTGPLFKRVLM 326
LQ++ N ++ D+V ++A A H LE C+ +T W G +
Sbjct: 313 LQMLQISN--LYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIK 370
Query: 327 SSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWP---- 382
+ G+TG +EF ED + + I+ Y+ T + W
Sbjct: 371 KG-HITGLTGVMEFREDSSNPYVQFEILGTT---------YSETFGKDMRKLATWDSEKG 420
Query: 383 --GGETEKPRGYQMS-TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGP 439
G E+P G ++ LK+VT+ +EPFV V +
Sbjct: 421 LNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENIL----------------------- 457
Query: 440 NDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWN 499
G P+ GF ID+L LA+ + F YE++ DG++G Q ++N++ WN
Sbjct: 458 -----GQPKRYK-----GFSIDVLDALAKALGFKYEIYQAPDGRYGHQ--LHNTS---WN 502
Query: 500 GMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQ 559
GM+GEL+S +AD+ ++ +TI ER ++FSK + + IL+KK + ++ S PF
Sbjct: 503 GMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFD 562
Query: 560 STLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGI 619
+W + ++ VV V++++L+R R + ++ + TL SA+W +G + G
Sbjct: 563 FAVWACIAAAIPVVGVLIFVLNRIQAV-RAQSAAQPRPSASATLHSAIWIVYGAFVQQG- 620
Query: 620 GEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKF 679
GE + S + RI+ W F +I+ +SYTANLAAFL + R + I D + +
Sbjct: 621 GESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQD---LSKQVEM 677
Query: 680 IYATVKQSSVDIYFR--------RQVELSTMYRHMEKHN-----YESAAEAIQAVRDNKL 726
Y TV+ S+V YFR + + ++R + K+ S +E I+ +
Sbjct: 678 SYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGN- 736
Query: 727 HAFIWDSAVLEFEA--SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGF 784
+AF+WD AV+E+ A C + G G+GI ++ SP++ S IL+ + G
Sbjct: 737 YAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGD 796
Query: 785 MEDL-DKTWVRYQECDSRSNAPA-----TLTFENMAGVFMLVAGGIVAGIFLIFIEI--- 835
++ L K W CD S+A A +L + AGVF ++A G++ + +E+
Sbjct: 797 LDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWN 856
Query: 836 AYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDP 874
+ + H++ ++ ++ V+ +L D + P
Sbjct: 857 SNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISP 895
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 198 bits (503), Expect = 2e-50
Identities = 220/924 (23%), Positives = 392/924 (42%), Gaps = 153/924 (16%)
Query: 6 LLTLALLFSCSVARAACDPKIVNIGAVL--STRKHEQMFREAVNQANKRHGSWKIQLNAT 63
LL L++ +S + A D I++IGA+ S +K +++FR AV N+ + +
Sbjct: 7 LLVLSVWWSRTWDSANAD-SIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITF 65
Query: 64 SVTHKP--NAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGL 121
SVT N Q CE L++ + A++ S T + + A IP L +
Sbjct: 66 SVTFVDGNNPFQAVQEACE-LMNQGILALVSSIGCT-----SAGSLQSLADAMHIPHLFI 119
Query: 122 TTRMSIYSDKSIHLS-------FLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR 174
+ L+ + +V P + V ++ Y+W I+ +++ R
Sbjct: 120 QRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIR 179
Query: 175 AAQKRLETL--------LEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASED 226
Q+ L+ + L++ E+ K++ T + L L +++++ +
Sbjct: 180 GIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPAT- 238
Query: 227 DAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI-------------- 272
A + N+ W++ EI+ ++ +G I
Sbjct: 239 -AKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQR 297
Query: 273 ---------------------NGKNESAHISDAVGVVAQAVHELLEKENITDPPR-GCVG 310
N + + +I D V ++A A H+ LE C+
Sbjct: 298 CFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIR 357
Query: 311 -NTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQ-----NRKLVQV 364
N+ W+ G + + G+TG +EF E+G ++ I+ R + ++
Sbjct: 358 KNSKPWQGGRSMLETIKKGGVS-GLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKL 416
Query: 365 GIYNGTHVIPNDRKIIWPGGETEKPRGYQM-STRLKIVTIHQEPFVYVKPTLSDGTCKEE 423
G +N + G T+K M L++VT+ +EPFV V
Sbjct: 417 GCWNPVTGLN--------GSLTDKKLENNMRGVVLRVVTVLEEPFVMVSEN--------- 459
Query: 424 FTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGK 483
V G P K GF ID+L L+ + F YE+++ D K
Sbjct: 460 --VLGKPKKY----------------------QGFSIDVLDALSNYLGFNYEIYVAPDHK 495
Query: 484 FGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVK 543
+G+ + WNG++GEL+ +AD+ ++ LTI +R ++F+ + + +L++
Sbjct: 496 YGSPQEDGT-----WNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550
Query: 544 KEIPRSTLDSF--MQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL 601
+ T+D F + PF +LW + +V +V +++YLL+ +P R ++ S +
Sbjct: 551 R--AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP-PRLQMGS----MTST 603
Query: 602 TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPE 661
TL ++MWF +G + G GE + + R++ W FA+I+++SYTANLAAFL + R E
Sbjct: 604 TLYNSMWFVYGSFVQQG-GEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIE 662
Query: 662 ERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ----VELSTMYRHM---------EK 708
I + D + + Y TV S+V + R + E +MY M +
Sbjct: 663 SSIQSLQD---LSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSE 719
Query: 709 HNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVTTGELFFRSGFGIGMRKDS 766
+N + IQ V+ +AF+WD+AVLE+ A C T G G+GI ++ S
Sbjct: 720 NNVLESQAGIQKVKYGN-YAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGS 778
Query: 767 PWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNAP-----ATLTFENMAGVFMLV 820
P++ S IL+ +NG M+ L K W + +CD S+ L ++ AGVF ++
Sbjct: 779 PYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCIL 838
Query: 821 AGGIVAGIFLIFIEIAYKRHKDAR 844
A GIV F+ +E + + K +R
Sbjct: 839 AAGIVLSCFIAMLETWWNKRKGSR 862
>gi|37577159 calcium-sensing receptor [Homo sapiens]
Length = 1078
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/158 (24%), Positives = 76/158 (48%), Gaps = 6/158 (3%)
Query: 105 TPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHII 164
T V+ G + IP + + + S+K+ SFLRT+P HQ++ +++ + WN +
Sbjct: 151 TAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVG 210
Query: 165 LLVSDDHEGRAAQKRLETLLEERE---SKAEKVLQFDPGTKNVTALLMEAKELEARVIIL 221
+ +DD GR ++ EER+ +E + Q+ + + ++ + A+VI++
Sbjct: 211 TIAADDDYGRPGIEKFREEAEERDICIDFSELISQYS-DEEEIQHVVEVIQNSTAKVIVV 269
Query: 222 SASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNAL 259
+S D + + N+TG +WL E S + +
Sbjct: 270 FSSGPDLEPLIKEIVRRNITGK--IWLASEAWASSSLI 305
Score = 30.8 bits (68), Expect = 6.2
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 12/71 (16%)
Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNL----QNRKLV--QVGIYN-----GTHVIPNDRK 378
+ + + +V F+E GD NYSI+N ++ +V +VG YN G + N+ K
Sbjct: 469 FTNNMGEQVTFDECGDL-VGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK 527
Query: 379 IIWPGGETEKP 389
I+W G E P
Sbjct: 528 ILWSGFSREVP 538
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,933,231
Number of Sequences: 37866
Number of extensions: 1533278
Number of successful extensions: 3761
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 3542
Number of HSP's gapped (non-prelim): 85
length of query: 938
length of database: 18,247,518
effective HSP length: 112
effective length of query: 826
effective length of database: 14,006,526
effective search space: 11569390476
effective search space used: 11569390476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.