Guide to the Human Genome
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Search of human proteins with 11038637

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo
sapiens]
         (938 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]   1877   0.0  
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]   1788   0.0  
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]   1732   0.0  
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ...   312   1e-84
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ...   298   2e-80
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ...   298   2e-80
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr...   298   2e-80
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [...   273   7e-73
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ...   265   1e-70
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ...   263   6e-70
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ...   258   1e-68
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p...   255   2e-67
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ...   253   4e-67
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat...   252   1e-66
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]           251   2e-66
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ...   248   2e-65
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H...   244   2e-64
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H...   244   4e-64
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate...   243   5e-64
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]           241   2e-63
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr...   236   7e-62
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H...   235   2e-61
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre...   235   2e-61
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p...   223   6e-58
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p...   222   1e-57
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p...   218   2e-56
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p...   218   2e-56
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H...   203   5e-52
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]   198   2e-50
gi|37577159 calcium-sensing receptor [Homo sapiens]                    60   1e-08

>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
          Length = 938

 Score = 1877 bits (4863), Expect = 0.0
 Identities = 938/938 (100%), Positives = 938/938 (100%)

Query: 1   MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60
           MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
Sbjct: 1   MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60

Query: 61  NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120
           NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
Sbjct: 61  NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120

Query: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180
           LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL
Sbjct: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180

Query: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240
           ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM
Sbjct: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240

Query: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300
           TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
Sbjct: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300

Query: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
           ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
Sbjct: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360

Query: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420
           LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC
Sbjct: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420

Query: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480
           KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
Sbjct: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480

Query: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540
           DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
Sbjct: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540

Query: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
           LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
Sbjct: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600

Query: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660
           LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
Sbjct: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660

Query: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720
           EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
Sbjct: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720

Query: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780
           VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
Sbjct: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780

Query: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840
           ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
Sbjct: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840

Query: 841 KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
           KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT
Sbjct: 841 KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900

Query: 901 STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES 938
           STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
Sbjct: 901 STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES 938


>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
          Length = 901

 Score = 1788 bits (4632), Expect = 0.0
 Identities = 901/938 (96%), Positives = 901/938 (96%), Gaps = 37/938 (3%)

Query: 1   MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60
           MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
Sbjct: 1   MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60

Query: 61  NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120
           NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
Sbjct: 61  NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120

Query: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180
           LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL
Sbjct: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180

Query: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240
           ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM
Sbjct: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240

Query: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300
           TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
Sbjct: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300

Query: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
           ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
Sbjct: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360

Query: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420
           LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC
Sbjct: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420

Query: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480
           KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
Sbjct: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480

Query: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540
           DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
Sbjct: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540

Query: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
           LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
Sbjct: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600

Query: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660
           LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
Sbjct: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660

Query: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720
           EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
Sbjct: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720

Query: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780
           VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
Sbjct: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780

Query: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840
           ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
Sbjct: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840

Query: 841 KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
           KDARRKQMQLAFAAVNVWRKNLQ                                     
Sbjct: 841 KDARRKQMQLAFAAVNVWRKNLQ------------------------------------- 863

Query: 901 STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES 938
           STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
Sbjct: 864 STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES 901


>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
          Length = 885

 Score = 1732 bits (4485), Expect = 0.0
 Identities = 863/863 (100%), Positives = 863/863 (100%)

Query: 1   MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60
           MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
Sbjct: 1   MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL 60

Query: 61  NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120
           NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
Sbjct: 61  NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG 120

Query: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180
           LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL
Sbjct: 121 LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL 180

Query: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240
           ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM
Sbjct: 181 ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM 240

Query: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300
           TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
Sbjct: 241 TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 300

Query: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
           ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
Sbjct: 301 ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360

Query: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420
           LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC
Sbjct: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC 420

Query: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480
           KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
Sbjct: 421 KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 480

Query: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540
           DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
Sbjct: 481 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI 540

Query: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
           LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
Sbjct: 541 LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600

Query: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660
           LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
Sbjct: 601 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 660

Query: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720
           EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
Sbjct: 661 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 720

Query: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780
           VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
Sbjct: 721 VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH 780

Query: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840
           ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
Sbjct: 781 ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 840

Query: 841 KDARRKQMQLAFAAVNVWRKNLQ 863
           KDARRKQMQLAFAAVNVWRKNLQ
Sbjct: 841 KDARRKQMQLAFAAVNVWRKNLQ 863


>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
           [Homo sapiens]
          Length = 1484

 Score =  312 bits (799), Expect = 1e-84
 Identities = 244/863 (28%), Positives = 440/863 (50%), Gaps = 71/863 (8%)

Query: 6   LLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSW--KIQLNAT 63
           L+   L  S S AR+   P  + I  +L     E   ++A  + +  H S   +++L A 
Sbjct: 14  LVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAM 73

Query: 64  SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
           + T   + I     +C DL+S +    +V    T  +      + + +     P+LG+  
Sbjct: 74  NETDPKSIITR---IC-DLMSDRKIQGVVFADDTDQEAIAQI-LDFISAQTLTPILGIHG 128

Query: 124 RMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG-RAAQKRLE 181
             S I +DK     F +  P    Q+SV   +M  Y W +I  +V+    G +    ++ 
Sbjct: 129 GSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDW-YIFSIVTTYFPGYQDFVNKIR 187

Query: 182 TLLEERES--KAEKVLQFDPGTKNVTALLM-EAKELEARVIILSASEDDAATVYRAAAML 238
           + +E      + E+VL  D    +  + +  + K+L++ +I+L  ++++A  ++  A  +
Sbjct: 188 STIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSV 247

Query: 239 NMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNES----AHISDAVGVVAQAVHE 294
            +TG GY W+V    ++G+      +   GL  ++         A + D + ++  A  +
Sbjct: 248 GLTGYGYTWIVPSL-VAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASD 306

Query: 295 LLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSS---KYADGVT--GR-VEFNEDGDRKF 348
           +L + +    P+    NT+        KR+  S+   +Y   VT  GR + F+EDG +  
Sbjct: 307 MLSEHSFIPEPKSSCYNTHE-------KRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMH 359

Query: 349 ANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPG--GETEKPRGYQMSTRLKIVTIHQ 405
               I+ L + RK  +VG +    +    +  +WP    ETE+    Q    L IVT+ +
Sbjct: 360 PKLVIILLNKERKWERVGKWKDKSL--QMKYYVWPRMCPETEE----QEDDHLSIVTLEE 413

Query: 406 EPFVYVKPTLS-DGTCKEEFTVNGDPVKKVICT-GPNDTSPGSPRHTVPQCCYGFCIDLL 463
            PFV V+      GTC      N  P +K I T    D  PG     + +CC GFCID+L
Sbjct: 414 APFVIVESVDPLSGTCMR----NTVPCQKRIVTENKTDEEPGY----IKKCCKGFCIDIL 465

Query: 464 IKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNER 523
            K+++++ FTY+++LV +GK G  +++N +    WNGM+GE++  +A M V  LTIN ER
Sbjct: 466 KKISKSVKFTYDLYLVTNGKHG--KKINGT----WNGMIGEVVMKRAYMAVGSLTINEER 519

Query: 524 AQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDR 582
           ++ ++FS PF   G++++V +     +  +F++PF + +W+++ + + +V AV +++ + 
Sbjct: 520 SEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEY 579

Query: 583 FSPFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFA 640
           FSP G  R   +  E    + T+  A+W  WG++ N+ +    P+  +++I+  VWA FA
Sbjct: 580 FSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFA 639

Query: 641 MIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQV 697
           +I +ASYTANLAAF++ +   ++++G++D + + P+D    F + TV   S +   R   
Sbjct: 640 VIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRN-- 697

Query: 698 ELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELF 753
             + M+ +M K N     +A+ +++  KL AFI+D+AVL + A   + C LVT  +G++F
Sbjct: 698 NYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVF 757

Query: 754 FRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFE 811
             +G+GI ++KDS WK+ V L+IL+   +G ME+L+  W+    C +  N    + L  +
Sbjct: 758 ASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT-GICHNEKNEVMSSQLDID 816

Query: 812 NMAGVFMLVAGGIVAGIFLIFIE 834
           NMAGVF ++   +   +     E
Sbjct: 817 NMAGVFYMLGAAMALSLITFICE 839


>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
           precursor [Homo sapiens]
          Length = 1281

 Score =  298 bits (762), Expect = 2e-80
 Identities = 215/741 (29%), Positives = 388/741 (52%), Gaps = 46/741 (6%)

Query: 116 IPVLGLTTRMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG- 173
           +P+LG+    S I +DK    +F +       Q++V  ++M+ Y W H+  LV+    G 
Sbjct: 122 VPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW-HVFSLVTTIFPGY 180

Query: 174 RAAQKRLETLLEERES--KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATV 231
           R     ++T ++        + V+  D   ++    + + K++ + VI+L  S+D+A  +
Sbjct: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLI 239

Query: 232 YRAAAMLNMTGSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKNE-SAHISDAVGV 287
              A  L +TG  + W+V    +SGN     +  P G++ +   +      A + D +G+
Sbjct: 240 LSEARSLGLTGYDFFWIVPSL-VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGI 298

Query: 288 VAQAVHELLEKEN-ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDR 346
           +  A   +LEK + I +    C G     +         M +   DG    + F E+G +
Sbjct: 299 LTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKD--LSFTEEGYQ 356

Query: 347 KFANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQ 405
                 ++ L ++R+  +VG +   H + + R  +WP  ++           L IVT+ +
Sbjct: 357 VHPRLVVIVLNKDREWEKVGKWEN-HTL-SLRHAVWPRYKSFSDCEPD-DNHLSIVTLEE 413

Query: 406 EPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIK 465
            PFV V+         E    N  P +K +    N T+ G     V +CC GFCID+L K
Sbjct: 414 APFVIVEDI---DPLTETCVRNTVPCRKFVKIN-NSTNEGM---NVKKCCKGFCIDILKK 466

Query: 466 LARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQ 525
           L+RT+ FTY+++LV +GK G  ++VNN     WNGM+GE++  +A M V  LTIN ER++
Sbjct: 467 LSRTVKFTYDLYLVTNGKHG--KKVNNV----WNGMIGEVVYQRAVMAVGSLTINEERSE 520

Query: 526 YIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDRFS 584
            ++FS PF   G++++V +     +  +F++PF +++W+++ + + +V A+ +++ + FS
Sbjct: 521 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFS 580

Query: 585 PFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
           P G  R     +     + T+  A+W  WG++ N+ +    P+  +++I+  VWA FA+I
Sbjct: 581 PVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVI 640

Query: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQVEL 699
            +ASYTANLAAF++ +   +++TG++D + + P D    F + TV   S +   R     
Sbjct: 641 FLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY 700

Query: 700 STMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFR 755
             M+++M K N +   +A+ +++  KL AFI+D+AVL ++A   + C LVT  +G +F  
Sbjct: 701 --MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 758

Query: 756 SGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFENM 813
           +G+GI ++K SPWK+ + L++L+   +G ME+L+  W+    C +  N    + L  +NM
Sbjct: 759 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT-GICHNEKNEVMSSQLDIDNM 817

Query: 814 AGVFMLVAGGIVAGIFLIFIE 834
           AGVF ++A  +   +     E
Sbjct: 818 AGVFYMLAAAMALSLITFIWE 838


>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
           precursor [Homo sapiens]
          Length = 1464

 Score =  298 bits (762), Expect = 2e-80
 Identities = 215/741 (29%), Positives = 388/741 (52%), Gaps = 46/741 (6%)

Query: 116 IPVLGLTTRMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG- 173
           +P+LG+    S I +DK    +F +       Q++V  ++M+ Y W H+  LV+    G 
Sbjct: 122 VPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW-HVFSLVTTIFPGY 180

Query: 174 RAAQKRLETLLEERES--KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATV 231
           R     ++T ++        + V+  D   ++    + + K++ + VI+L  S+D+A  +
Sbjct: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLI 239

Query: 232 YRAAAMLNMTGSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKNE-SAHISDAVGV 287
              A  L +TG  + W+V    +SGN     +  P G++ +   +      A + D +G+
Sbjct: 240 LSEARSLGLTGYDFFWIVPSL-VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGI 298

Query: 288 VAQAVHELLEKEN-ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDR 346
           +  A   +LEK + I +    C G     +         M +   DG    + F E+G +
Sbjct: 299 LTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKD--LSFTEEGYQ 356

Query: 347 KFANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQ 405
                 ++ L ++R+  +VG +   H + + R  +WP  ++           L IVT+ +
Sbjct: 357 VHPRLVVIVLNKDREWEKVGKWEN-HTL-SLRHAVWPRYKSFSDCEPD-DNHLSIVTLEE 413

Query: 406 EPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIK 465
            PFV V+         E    N  P +K +    N T+ G     V +CC GFCID+L K
Sbjct: 414 APFVIVEDI---DPLTETCVRNTVPCRKFVKIN-NSTNEGM---NVKKCCKGFCIDILKK 466

Query: 466 LARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQ 525
           L+RT+ FTY+++LV +GK G  ++VNN     WNGM+GE++  +A M V  LTIN ER++
Sbjct: 467 LSRTVKFTYDLYLVTNGKHG--KKVNNV----WNGMIGEVVYQRAVMAVGSLTINEERSE 520

Query: 526 YIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDRFS 584
            ++FS PF   G++++V +     +  +F++PF +++W+++ + + +V A+ +++ + FS
Sbjct: 521 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFS 580

Query: 585 PFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
           P G  R     +     + T+  A+W  WG++ N+ +    P+  +++I+  VWA FA+I
Sbjct: 581 PVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVI 640

Query: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQVEL 699
            +ASYTANLAAF++ +   +++TG++D + + P D    F + TV   S +   R     
Sbjct: 641 FLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY 700

Query: 700 STMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFR 755
             M+++M K N +   +A+ +++  KL AFI+D+AVL ++A   + C LVT  +G +F  
Sbjct: 701 --MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 758

Query: 756 SGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFENM 813
           +G+GI ++K SPWK+ + L++L+   +G ME+L+  W+    C +  N    + L  +NM
Sbjct: 759 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT-GICHNEKNEVMSSQLDIDNM 817

Query: 814 AGVFMLVAGGIVAGIFLIFIE 834
           AGVF ++A  +   +     E
Sbjct: 818 AGVFYMLAAAMALSLITFIWE 838


>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
           precursor [Homo sapiens]
          Length = 1464

 Score =  298 bits (762), Expect = 2e-80
 Identities = 215/741 (29%), Positives = 388/741 (52%), Gaps = 46/741 (6%)

Query: 116 IPVLGLTTRMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG- 173
           +P+LG+    S I +DK    +F +       Q++V  ++M+ Y W H+  LV+    G 
Sbjct: 122 VPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW-HVFSLVTTIFPGY 180

Query: 174 RAAQKRLETLLEERES--KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATV 231
           R     ++T ++        + V+  D   ++    + + K++ + VI+L  S+D+A  +
Sbjct: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLI 239

Query: 232 YRAAAMLNMTGSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKNE-SAHISDAVGV 287
              A  L +TG  + W+V    +SGN     +  P G++ +   +      A + D +G+
Sbjct: 240 LSEARSLGLTGYDFFWIVPSL-VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGI 298

Query: 288 VAQAVHELLEKEN-ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDR 346
           +  A   +LEK + I +    C G     +         M +   DG    + F E+G +
Sbjct: 299 LTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKD--LSFTEEGYQ 356

Query: 347 KFANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQ 405
                 ++ L ++R+  +VG +   H + + R  +WP  ++           L IVT+ +
Sbjct: 357 VHPRLVVIVLNKDREWEKVGKWEN-HTL-SLRHAVWPRYKSFSDCEPD-DNHLSIVTLEE 413

Query: 406 EPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIK 465
            PFV V+         E    N  P +K +    N T+ G     V +CC GFCID+L K
Sbjct: 414 APFVIVEDI---DPLTETCVRNTVPCRKFVKIN-NSTNEGM---NVKKCCKGFCIDILKK 466

Query: 466 LARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQ 525
           L+RT+ FTY+++LV +GK G  ++VNN     WNGM+GE++  +A M V  LTIN ER++
Sbjct: 467 LSRTVKFTYDLYLVTNGKHG--KKVNNV----WNGMIGEVVYQRAVMAVGSLTINEERSE 520

Query: 526 YIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDRFS 584
            ++FS PF   G++++V +     +  +F++PF +++W+++ + + +V A+ +++ + FS
Sbjct: 521 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFS 580

Query: 585 PFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
           P G  R     +     + T+  A+W  WG++ N+ +    P+  +++I+  VWA FA+I
Sbjct: 581 PVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVI 640

Query: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQVEL 699
            +ASYTANLAAF++ +   +++TG++D + + P D    F + TV   S +   R     
Sbjct: 641 FLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY 700

Query: 700 STMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFR 755
             M+++M K N +   +A+ +++  KL AFI+D+AVL ++A   + C LVT  +G +F  
Sbjct: 701 --MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 758

Query: 756 SGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFENM 813
           +G+GI ++K SPWK+ + L++L+   +G ME+L+  W+    C +  N    + L  +NM
Sbjct: 759 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT-GICHNEKNEVMSSQLDIDNM 817

Query: 814 AGVFMLVAGGIVAGIFLIFIE 834
           AGVF ++A  +   +     E
Sbjct: 818 AGVFYMLAAAMALSLITFIWE 838


>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
           [Homo sapiens]
          Length = 1233

 Score =  273 bits (697), Expect = 7e-73
 Identities = 222/824 (26%), Positives = 396/824 (48%), Gaps = 66/824 (8%)

Query: 116 IPVLGLTTRMSIY-SDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR 174
           +P+L ++   ++  + K    +FL+       Q  V F+++  Y W+   ++ S  H G 
Sbjct: 117 VPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSL-HPGH 175

Query: 175 AAQKRLETLLEERESKAEKVL-----QFDPGTKNVTALLMEAKELEARVIILSASEDDAA 229
           A        + +    + ++L     +  PG        +  ++L+A V +   S ++A 
Sbjct: 176 ALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRL-LRQLDAPVFVAYCSREEAE 234

Query: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHIS------D 283
            ++  AA   + G G+VWLV    +       AP     + LI+   ES  +S      D
Sbjct: 235 VLFAEAAQAGLVGPGHVWLVPNLALGSTD---APPATFPVGLISVVTESWRLSLRQKVRD 291

Query: 284 AVGVVAQAVHELLEKENITDPPRG-C-VGNTNIWKTGPLFKRVLMSSKYADGVTGR-VEF 340
            V ++A   H    +      P G C V    +      F R L++  +     GR   F
Sbjct: 292 GVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWE----GRDFSF 347

Query: 341 NEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKI 400
           +  G        ++ L   +L ++ +    H +   +  +WP            S  L +
Sbjct: 348 SPGGYLVQPTMVVIALNRHRLWEM-VGRWEHGVLYMKYPVWPRYSASLQPVVD-SRHLTV 405

Query: 401 VTIHQEPFVYVK-PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC 459
            T+ + PFV V+ P    G C      N  P ++      +  S G        CC GFC
Sbjct: 406 ATLEERPFVIVESPDPGTGGC----VPNTVPCRR---QSNHTFSSGDVAPYTKLCCKGFC 458

Query: 460 IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTI 519
           ID+L KLAR + F+Y+++LV +GK G + R        WNGM+GE+   +ADM +  LTI
Sbjct: 459 IDILKKLARVVKFSYDLYLVTNGKHGKRVR------GVWNGMIGEVYYKRADMAIGSLTI 512

Query: 520 NNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVG-LSVHVVAVMLY 578
           N ER++ ++FS PF   G++++V +     +  +F++P+   +W+++  + + VVA+ ++
Sbjct: 513 NEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVF 572

Query: 579 LLDRFSP--FGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVW 636
           + + FSP  + +     ++    A T+  ++W  W ++ N+ +    PR  +++I+ +VW
Sbjct: 573 MFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVW 632

Query: 637 AGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDK---FIYATVKQSSVDIYF 693
           A FA+I +ASYTANLAAF++ ++  + ++G++D + + P D+   F + TV   S +   
Sbjct: 633 AFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNI 692

Query: 694 RRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--T 749
           R       M+ HM K N  S  +A+ +++  KL AFI+D+AVL + A   + C LVT  +
Sbjct: 693 RSNYR--DMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGS 750

Query: 750 GELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APAT 807
           G++F  +G+GI M+KDS WK+ + L++L+   +G  + L+  W+    C +  N    + 
Sbjct: 751 GKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLS-GICQNEKNEVMSSK 809

Query: 808 LTFENMAGVF--MLVAGGIVAGIFLIFIEIAYK-RHKDARRKQMQLAFAAVNVWRKNLQD 864
           L  +NMAGVF  +LVA G+   +F     + +K RH      Q+    A    + + +  
Sbjct: 810 LDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLA----FSRGIYS 865

Query: 865 RKSG---RAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGG 905
             SG    A P P++ +     +S  AS  K  ++++D  T  G
Sbjct: 866 CFSGVQSLASP-PRQASPDLTASSAQASVLKMLQAARDMVTTAG 908


>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
           precursor [Homo sapiens]
          Length = 905

 Score =  265 bits (677), Expect = 1e-70
 Identities = 242/953 (25%), Positives = 436/953 (45%), Gaps = 131/953 (13%)

Query: 10  ALLFSCSVARAACDPKIVNIGAVLSTRKHEQM------FREAVNQANKRHGSWKIQLNAT 63
           ALL+          P+++ IG +  T ++E +      F+ AV   N+     +  +  T
Sbjct: 20  ALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN----RTLMPNT 75

Query: 64  SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
           ++T+    I +  S      +    A+ V+    P+   + + V        +P   + T
Sbjct: 76  TLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVP--HIQT 133

Query: 124 RMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETL 183
           R    S  +  L ++   P Y+  S    +++  Y+W  + ++  D         RL+ L
Sbjct: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS----TGLIRLQEL 189

Query: 184 LE--ERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMT 241
           ++   R +   K+ Q   G K+   LL E K+ +   +I   S + AA + +    + M 
Sbjct: 190 IKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMM 249

Query: 242 GSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKN---------------------- 276
              Y +     ++    L   RY+   + G +L+N  N                      
Sbjct: 250 TEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309

Query: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
                     E+A + DAV +VA A H   +   +T     C  +   W+ GP F  ++ 
Sbjct: 310 TGLLDGMMTTEAALMYDAVYMVAIASHRASQ---LTVSSLQCHRHKP-WRLGPRFMNLIK 365

Query: 327 SSKYADGVTGRVEFNE-DGDRKFANYSIMNLQNRKLVQVGIYN---GTHVIPNDRKIIWP 382
            +++ DG+TG + FN+ +G RK  +  I++L+     ++GI+N   G ++  +++     
Sbjct: 366 EARW-DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKD---- 420

Query: 383 GGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDT 442
             ++        +  L + TI +EP+V  +        K +  + G           ND 
Sbjct: 421 --KSSNITDSLANRTLIVTTILEEPYVMYR--------KSDKPLYG-----------NDR 459

Query: 443 SPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMM 502
             G            +C+DLL +L+  + F Y+V LV DGK+G Q     ++K EWNGM+
Sbjct: 460 FEG------------YCLDLLKELSNILGFIYDVKLVPDGKYGAQ-----NDKGEWNGMV 502

Query: 503 GELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST---LDSFMQPFQ 559
            EL+  +AD+ VAPLTI   R + I+FSKPF   G++IL +K  P  T   + SF+ P  
Sbjct: 503 KELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK--PNGTNPGVFSFLNPLS 560

Query: 560 STLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL----TLSSAMWFSWGVLL 615
             +W+ V L+   V+ +L+++ RF+P+  +  +    + D +    TL ++ WF  G L+
Sbjct: 561 PDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALM 620

Query: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
             G  E  P++ S RI+G +W  F +II++SYTANLAAFL ++R E  I   +D   +  
Sbjct: 621 QQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT- 678

Query: 676 SDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN----YESAAEAIQAVRDNKLHA 728
             K  Y  V+  S   +F++  ++ST   M+  M          ++ E IQ V     +A
Sbjct: 679 --KIEYGAVRDGSTMTFFKKS-KISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTD-YA 734

Query: 729 FIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDL 788
            + +S  +E+   + C+L   G L    G+G+G    SP++  ++++IL+  E G +  +
Sbjct: 735 LLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMM 794

Query: 789 DKTWVRYQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ 847
            + W R   C    N  A+ L  EN+ G+F+++A G+V  +F+   E  YK  K+   +Q
Sbjct: 795 KEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQ 854

Query: 848 MQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
                A +     +L+++K  + +   K K++F    +++ +  +RR   K+T
Sbjct: 855 CLSFNAIMEELGISLKNQKKIKKKSRTKGKSSF----TSILTCHQRRTQRKET 903


>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
           [Homo sapiens]
          Length = 1336

 Score =  263 bits (672), Expect = 6e-70
 Identities = 196/725 (27%), Positives = 356/725 (49%), Gaps = 52/725 (7%)

Query: 136 SFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEK-- 193
           +FL+       Q  V FE++  Y W   + + +     RA    +E L +      E   
Sbjct: 160 TFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRG 219

Query: 194 VLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGERE 253
            L  DPG      L  + + + A++ +L  + ++A  V+RAA    +TGSGYVW +   +
Sbjct: 220 ALTLDPGAGEAV-LSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQ 278

Query: 254 ISGNALRYAPD-------------GILGLQLINGKNESAH-ISDAVGVVAQAVHELLEKE 299
           ++G     AP              G+  ++    +++ A  ++  V VVA+    LL   
Sbjct: 279 LAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDY 338

Query: 300 NITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNR 359
                        N    G    R  M+  + +       FNEDG     +  +++L   
Sbjct: 339 GFLPELGHDCRAQNRTHRGESLHRYFMNITWDNR---DYSFNEDGFLVNPSLVVISLTRD 395

Query: 360 KLVQVGIYNGTHVIPNDRKIIWPG-GETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLS-D 417
           +  +V + +        +  +W   G   +P     +  L + T+ + PFV V+P     
Sbjct: 396 RTWEV-VGSWEQQTLRLKYPLWSRYGRFLQP--VDDTQHLTVATLEERPFVIVEPADPIS 452

Query: 418 GTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVH 477
           GTC  +       + +      +   P +PR    +CC GFCID+L +LA T+ F+Y+++
Sbjct: 453 GTCIRDSVPCRSQLNRT-----HSPPPDAPRPE-KRCCKGFCIDILKRLAHTIGFSYDLY 506

Query: 478 LVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQG 537
           LV +GK G  ++++      WNGM+GE+   +ADM +  LTIN ER++ ++FS PF   G
Sbjct: 507 LVTNGKHG--KKIDGV----WNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETG 560

Query: 538 LTILVKKEIPRSTLDSFMQPFQSTLWLLVG-LSVHVVAVMLYLLDRFSPFG--RFKVNSE 594
           ++++V +     +  +F++P+   +W+++  + + VVAV +++ +  SP G  R     +
Sbjct: 561 ISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGK 620

Query: 595 EEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAF 654
                  T+  ++W  W ++ N+ +    PR  +++I+ +VWA FA+I +ASYTANLAAF
Sbjct: 621 RPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAF 680

Query: 655 LVLDRPEERITGINDPRLRNPSDKF---IYATVKQSSVDIYFRRQVELSTMYRHMEKHNY 711
           ++ +   + ++G++D + + P +++    + TV   S +   R       M+ +M ++N 
Sbjct: 681 MIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRS--NYPDMHSYMVRYNQ 738

Query: 712 ESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFRSGFGIGMRKDSP 767
               EA+  ++  KL AFI+D+AVL + A   + C LVT  +G++F  +G+GI + K S 
Sbjct: 739 PRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSR 798

Query: 768 WKQNVSLSILKSHENGFMEDLDKTWVR-YQECDSRSNAPATLTFENMAGVF--MLVAGGI 824
           WK+ + L++L+   +  +E L++ W+      D      + L  +NMAGVF  +LVA G+
Sbjct: 799 WKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGL 858

Query: 825 VAGIF 829
              +F
Sbjct: 859 SLLVF 863


>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
           precursor [Homo sapiens]
          Length = 908

 Score =  258 bits (660), Expect = 1e-68
 Identities = 231/895 (25%), Positives = 410/895 (45%), Gaps = 130/895 (14%)

Query: 39  EQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM-----ALSVCEDLISSQVYAILVS 93
           E  FR AVN  N+     +  L  T++T+    I +     A     D +S  V AI   
Sbjct: 54  ELAFRFAVNTINRN----RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIF-- 107

Query: 94  HPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE 153
               P+   +   V        +P +    +  +  +K     ++   P +S  S    +
Sbjct: 108 ---GPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSSLSRAILD 162

Query: 154 MMRVYSWNHIILLVSDDHEGRAAQKRLETLLE--ERESKAEKVLQFDPGTKNVTALLMEA 211
           +++ + W   + +V DD  G     RL+ L++   R +   K+ Q    TK+   LL E 
Sbjct: 163 LVQFFKWK-TVTVVYDDSTGLI---RLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM 218

Query: 212 KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG---NALRYAPDGILG 268
           K  +   +I   S + AA + + A  + M    Y ++    ++        RY+   + G
Sbjct: 219 KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278

Query: 269 LQLINGKN--------------------------------ESAHISDAVGVVAQAVHELL 296
            +++N +N                                ++A + DAV VV+ AV +  
Sbjct: 279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFP 338

Query: 297 EKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNE-DGDRKFANYSIMN 355
           +   +T     C      W+ G  F  ++  + + +G+TGR+ FN+ +G R   +  +++
Sbjct: 339 Q---MTVSSLQC-NRHKPWRFGTRFMSLIKEAHW-EGLTGRITFNKTNGLRTDFDLDVIS 393

Query: 356 LQNRKLVQVGIYN---GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVK 412
           L+   L ++G ++   G ++  + +      G+         +  L + TI +EP+V  K
Sbjct: 394 LKEEGLEKIGTWDPASGLNMTESQK------GKPANITDSLSNRSLIVTTILEEPYVLFK 447

Query: 413 PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNF 472
                   K +  + G           ND   G            +CIDLL +L+  + F
Sbjct: 448 --------KSDKPLYG-----------NDRFEG------------YCIDLLRELSTILGF 476

Query: 473 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP 532
           TYE+ LV DGK+G Q+  N     +WNGM+ EL+  +AD+ VAPL I   R + I+FSKP
Sbjct: 477 TYEIRLVEDGKYGAQDDANG----QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532

Query: 533 FKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRF 589
           F   G++IL +K  P  T   + SF+ P    +W+ + L+   V+ +L+++ RFSP+  +
Sbjct: 533 FMTLGISILYRK--PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY 590

Query: 590 KVNSEEEEEDAL----TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVA 645
             +    + D +    TL ++ WF  G L+  G  E  P++ S RI+G +W  F +II++
Sbjct: 591 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIIS 649

Query: 646 SYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---M 702
           SYTANLAAFL ++R E  I   +D   +    K  Y  V+  +   +F++  ++ST   M
Sbjct: 650 SYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVEDGATMTFFKKS-KISTYDKM 705

Query: 703 YRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGF 758
           +  M         +S  E IQ V  +  +AF+ +S  +EF   + C+L   G L    G+
Sbjct: 706 WAFMSSRRQSVLVKSNEEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGY 764

Query: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC-DSRSNAPATLTFENMAGVF 817
           G+G    SP++  ++++IL+  E G +  + + W R   C +  S   + L  +N+ G+F
Sbjct: 765 GVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIF 824

Query: 818 MLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEP 872
           +++A G+V  +F+   E  YK  K+A+ ++     A V   R +L+ ++  + +P
Sbjct: 825 IVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKP 879


>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
           precursor [Homo sapiens]
          Length = 918

 Score =  255 bits (651), Expect = 2e-67
 Identities = 233/904 (25%), Positives = 408/904 (45%), Gaps = 130/904 (14%)

Query: 10  ALLFSCSVARAACDPKIVNIGAVLSTRKHEQM------FREAVNQANKRHGSWKIQLNAT 63
           ALL+          P+++ IG +  T ++E +      F+ AV   N+     +  +  T
Sbjct: 20  ALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN----RTLMPNT 75

Query: 64  SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
           ++T+    I +  S      +    A+ V+    P+   + + V        +P   + T
Sbjct: 76  TLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVP--HIQT 133

Query: 124 RMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETL 183
           R    S  +  L ++   P Y+  S    +++  Y+W  + ++  D         RL+ L
Sbjct: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS----TGLIRLQEL 189

Query: 184 LE--ERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMT 241
           ++   R +   K+ Q   G K+   LL E K+ +   +I   S + AA + +    + M 
Sbjct: 190 IKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMM 249

Query: 242 GSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKN---------------------- 276
              Y +     ++    L   RY+   + G +L+N  N                      
Sbjct: 250 TEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309

Query: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
                     E+A + DAV +VA A H   +   +T     C  +   W+ GP F  ++ 
Sbjct: 310 TGLLDGMMTTEAALMYDAVYMVAIASHRASQ---LTVSSLQCHRHKP-WRLGPRFMNLIK 365

Query: 327 SSKYADGVTGRVEFNE-DGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKI-IWPGG 384
            +++ DG+TG + FN+ +G RK  +  I++L+     +       H+    +KI IW   
Sbjct: 366 EARW-DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSN 424

Query: 385 ------ETEKPRGYQMSTRLK-----IVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKK 433
                 ++ K +   ++  L      + TI +EP+V  +        K +  + G     
Sbjct: 425 SGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYR--------KSDKPLYG----- 471

Query: 434 VICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNS 493
                 ND   G            +C+DLL +L+  + F Y+V LV DGK+G Q     +
Sbjct: 472 ------NDRFEG------------YCLDLLKELSNILGFIYDVKLVPDGKYGAQ-----N 508

Query: 494 NKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST--- 550
           +K EWNGM+ EL+  +AD+ VAPLTI   R + I+FSKPF   G++IL +K  P  T   
Sbjct: 509 DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK--PNGTNPG 566

Query: 551 LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL----TLSSA 606
           + SF+ P    +W+ V L+   V+ +L+++ RF+P+  +  +    + D +    TL ++
Sbjct: 567 VFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNS 626

Query: 607 MWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITG 666
            WF  G L+  G  E  P++ S RI+G +W  F +II++SYTANLAAFL ++R E  I  
Sbjct: 627 FWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 685

Query: 667 INDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN----YESAAEAIQ 719
            +D   +    K  Y  V+  S   +F++  ++ST   M+  M          ++ E IQ
Sbjct: 686 ADDLAKQT---KIEYGAVRDGSTMTFFKKS-KISTYEKMWAFMSSRQQTALVRNSDEGIQ 741

Query: 720 AVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKS 779
            V     +A + +S  +E+   + C+L   G L    G+G+G    SP++  ++++IL+ 
Sbjct: 742 RVLTTD-YALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQL 800

Query: 780 HENGFMEDLDKTWVRYQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYK 838
            E G +  + + W R   C    N  A+ L  EN+ G+F+++A G+V  +F+   E  YK
Sbjct: 801 QEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYK 860

Query: 839 RHKD 842
             K+
Sbjct: 861 SRKN 864


>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
           precursor [Homo sapiens]
          Length = 869

 Score =  253 bits (647), Expect = 4e-67
 Identities = 226/867 (26%), Positives = 397/867 (45%), Gaps = 130/867 (14%)

Query: 39  EQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM-----ALSVCEDLISSQVYAILVS 93
           E  FR AVN  N+     +  L  T++T+    I +     A     D +S  V AI   
Sbjct: 54  ELAFRFAVNTINRN----RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIF-- 107

Query: 94  HPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE 153
               P+   +   V        +P +    +  +  +K     ++   P +S  S    +
Sbjct: 108 ---GPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSSLSRAILD 162

Query: 154 MMRVYSWNHIILLVSDDHEGRAAQKRLETLLE--ERESKAEKVLQFDPGTKNVTALLMEA 211
           +++ + W   + +V DD  G     RL+ L++   R +   K+ Q    TK+   LL E 
Sbjct: 163 LVQFFKWK-TVTVVYDDSTGLI---RLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM 218

Query: 212 KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG---NALRYAPDGILG 268
           K  +   +I   S + AA + + A  + M    Y ++    ++        RY+   + G
Sbjct: 219 KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278

Query: 269 LQLINGKN--------------------------------ESAHISDAVGVVAQAVHELL 296
            +++N +N                                ++A + DAV VV+ AV +  
Sbjct: 279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFP 338

Query: 297 EKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNE-DGDRKFANYSIMN 355
           +   +T     C      W+ G  F  ++  + + +G+TGR+ FN+ +G R   +  +++
Sbjct: 339 Q---MTVSSLQC-NRHKPWRFGTRFMSLIKEAHW-EGLTGRITFNKTNGLRTDFDLDVIS 393

Query: 356 LQNRKLVQVGIYN---GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVK 412
           L+   L ++G ++   G ++  + +      G+         +  L + TI +EP+V  K
Sbjct: 394 LKEEGLEKIGTWDPASGLNMTESQK------GKPANITDSLSNRSLIVTTILEEPYVLFK 447

Query: 413 PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNF 472
                   K +  + G           ND   G            +CIDLL +L+  + F
Sbjct: 448 --------KSDKPLYG-----------NDRFEG------------YCIDLLRELSTILGF 476

Query: 473 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP 532
           TYE+ LV DGK+G Q+  N     +WNGM+ EL+  +AD+ VAPL I   R + I+FSKP
Sbjct: 477 TYEIRLVEDGKYGAQDDANG----QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532

Query: 533 FKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRF 589
           F   G++IL +K  P  T   + SF+ P    +W+ + L+   V+ +L+++ RFSP+  +
Sbjct: 533 FMTLGISILYRK--PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY 590

Query: 590 KVNSEEEEEDAL----TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVA 645
             +    + D +    TL ++ WF  G L+  G  E  P++ S RI+G +W  F +II++
Sbjct: 591 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIIS 649

Query: 646 SYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---M 702
           SYTANLAAFL ++R E  I   +D   +    K  Y  V+  +   +F++  ++ST   M
Sbjct: 650 SYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVEDGATMTFFKKS-KISTYDKM 705

Query: 703 YRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGF 758
           +  M         +S  E IQ V  +  +AF+ +S  +EF   + C+L   G L    G+
Sbjct: 706 WAFMSSRRQSVLVKSNEEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGY 764

Query: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC-DSRSNAPATLTFENMAGVF 817
           G+G    SP++  ++++IL+  E G +  + + W R   C +  S   + L  +N+ G+F
Sbjct: 765 GVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIF 824

Query: 818 MLVAGGIVAGIFLIFIEIAYKRHKDAR 844
           +++A G+V  +F+   E  YK  K+A+
Sbjct: 825 IVLAAGLVLSVFVAVGEFLYKSKKNAQ 851


>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
           3A [Homo sapiens]
          Length = 1115

 Score =  252 bits (643), Expect = 1e-66
 Identities = 191/668 (28%), Positives = 332/668 (49%), Gaps = 71/668 (10%)

Query: 199 PGTKNVTALLM----EAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREI 254
           P T+++ + L       K     V++     +    ++       +      W++G+   
Sbjct: 302 PSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGD--- 358

Query: 255 SGNALRYAPDGI-LGLQLINGKNESA----HISDAVGVVAQAVHE--LLEKENITDPPR- 306
           S N      +G+ LGL + +GK   +    ++ DA+ +VA+AV    +++ E    P   
Sbjct: 359 SQNVEELRTEGLPLGL-IAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTM 417

Query: 307 GC--VGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFAN-YSIMNLQNRKL-- 361
            C  V  TN+  +G    R L ++ +  G++G +           N + I NLQ+  +  
Sbjct: 418 NCMEVETTNL-TSGQYLSRFLANTTFR-GLSGSIRVKGSTIVSSENNFFIWNLQHDPMGK 475

Query: 362 ---VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRL--KIVTIHQEPFVYVKPTLS 416
               ++G + G  ++ +    IWP         +Q  ++L  ++VT+ + PFV+ +    
Sbjct: 476 PMWTRLGSWQGGKIVMDYG--IWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDD 533

Query: 417 DGTCKEEFTVNGDPVKKVICTGP--NDTSP--------GSPRHTVP----QCCYGFCIDL 462
           +G C         P  + +C  P  ND+S          S   TVP    +CCYG+CIDL
Sbjct: 534 EGLC---------PAGQ-LCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDL 583

Query: 463 LIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNE 522
           L K+A  MNF +++++V DGK+G  +  +      W G++G+LL G A M V   +IN  
Sbjct: 584 LEKIAEDMNFDFDLYIVGDGKYGAWKNGH------WTGLVGDLLRGTAHMAVTSFSINTA 637

Query: 523 RAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDR 582
           R+Q I+F+ PF    L ILV+     + + +FM P   T+WL + +++H+ AV L L + 
Sbjct: 638 RSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEW 697

Query: 583 FSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
            SPFG              + SSA+   + +L    +    P+ ++ R L  +WA F M 
Sbjct: 698 KSPFG--LTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMF 755

Query: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTM 702
            +++YTANLAA +V ++  E ++GI+DP+L +PS  F + TV++SS + Y R+      M
Sbjct: 756 CLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ--SFPEM 813

Query: 703 YRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEAS--QKCDLVTTGELFFRSGF 758
           + +M ++N  +  + ++ ++++  KL AFI D A+L++E S    C L+T G+ F   G+
Sbjct: 814 HEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGY 873

Query: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNA---PATLTFENMAG 815
           GIG+  +SP   N+S  I +   +GFM+ L   W R   C  RS A      +  ++ +G
Sbjct: 874 GIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSG 933

Query: 816 VFMLVAGG 823
           +F+L+  G
Sbjct: 934 LFVLLCIG 941


>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
          Length = 980

 Score =  251 bits (641), Expect = 2e-66
 Identities = 206/752 (27%), Positives = 335/752 (44%), Gaps = 92/752 (12%)

Query: 201 TKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLV----------- 249
           +++ T LL E ++ +   II+ A+   +  + R A+ L MT + Y +++           
Sbjct: 196 SRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLD 255

Query: 250 GEREISGNALRYA---------PDGILGLQLINGKN-----------ESAHISDAVGVVA 289
           G  E S N L ++         P+ +  L +   +N            +A + DAV VV 
Sbjct: 256 GIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVV 315

Query: 290 QAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFA 349
            AV EL   + I   P  C  + NIW  G      L   +Y DG+TGRVEFN  G R   
Sbjct: 316 SAVRELNRSQEIGVKPLACT-SANIWPHGTSLMNYLRMVEY-DGLTGRVEFNSKGQRTNY 373

Query: 350 NYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFV 409
              I+    +   ++G++     +  +   +    +    +     T L + TI + P+V
Sbjct: 374 TLRILEKSRQGHREIGVWYSNRTLAMNATTL----DINLSQTLANKT-LVVTTILENPYV 428

Query: 410 YVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLART 469
             +P     +  E F                                GFC+D+L +LA  
Sbjct: 429 MRRPNFQALSGNERFE-------------------------------GFCVDMLRELAEL 457

Query: 470 MNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEF 529
           + F Y + LV DG +G  E  N S    W GM+GEL++ +AD+ VA  TI  ER + I+F
Sbjct: 458 LRFRYRLRLVEDGLYGAPEP-NGS----WTGMVGELINRKADLAVAAFTITAEREKVIDF 512

Query: 530 SKPFKYQGLTILVKKEIPRST-LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGR 588
           SKPF   G++IL +  + R     SF+ PF   +WL + L+   V+ +L+L  R SP+  
Sbjct: 513 SKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW 572

Query: 589 FKVN-----SEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMII 643
           +  +          E+  TL +++WF  G  +  G  E  PR+ S R +  VW  F +II
Sbjct: 573 YNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQG-SEIMPRALSTRCVSGVWWAFTLII 631

Query: 644 VASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFR--RQVELST 701
           ++SYTANLAAFL + R E  +   +D           Y T+   S   +F+  R      
Sbjct: 632 ISSYTANLAAFLTVQRMEVPVESADD---LADQTNIEYGTIHAGSTMTFFQNSRYQTYQR 688

Query: 702 MYRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSG 757
           M+ +M+        +S  E I  V  N  +AF+ +S + E+     C+L   G L    G
Sbjct: 689 MWNYMQSKQPSVFVKSTEEGIARVL-NSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKG 747

Query: 758 FGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPAT-LTFENMAGV 816
           +GIGM   SP++  ++L+IL+  EN  +E L + W     C    +  A  L  EN+ G+
Sbjct: 748 YGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGI 807

Query: 817 FMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKK 876
           F+++  G++  +F+  +E  +   + A  +++ +    +   R  +  RK+ R+    + 
Sbjct: 808 FIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRP 867

Query: 877 KATFRAITSTLASSFKRRRSSKDTSTGGGRGA 908
               RA+ S  A    R  + K  S G G  A
Sbjct: 868 GGPSRALLSLRAVREMRLSNGKLYSAGAGGDA 899


>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
           [Homo sapiens]
          Length = 919

 Score =  248 bits (633), Expect = 2e-65
 Identities = 220/821 (26%), Positives = 376/821 (45%), Gaps = 119/821 (14%)

Query: 137 FLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQ 196
           ++   P Y+  S    ++++   W    + V DD  G    + L  +   R +   K+ Q
Sbjct: 149 YVNLYPDYASLSHAILDLVQYLKWRSATV-VYDDSTGLIRLQEL-IMAPSRYNIRLKIRQ 206

Query: 197 FDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG 256
               + +   LL E K      II   S   AA + + A  + M    Y ++    ++  
Sbjct: 207 LPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYA 266

Query: 257 NAL---RYAPDGILGLQLINGKNESAHIS--------DAVGVVAQAVHELLEKENITDP- 304
             L   RY+   + G +++N  N   H+S        + +    ++   LL+   +TD  
Sbjct: 267 LDLEPYRYSGVNLTGFRILNVDNP--HVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAA 324

Query: 305 ----------------PRGCVGNTNI-----WKTGPLFKRVLMSSKYADGVTGRVEFNE- 342
                           P+  V +        W+ G  F   +  +++ +G+TGR+ FN+ 
Sbjct: 325 LLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQW-EGLTGRIVFNKT 383

Query: 343 DGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLK--- 399
            G R   +  I++L+   L +VG+++     P D   I    E  K RG  ++  L    
Sbjct: 384 SGLRTDFDLDIISLKEDGLEKVGVWS-----PADGLNIT---EVAKGRGPNVTDSLTNRS 435

Query: 400 --IVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYG 457
             + T+ +EPFV  +        K + T+ G           ND   G            
Sbjct: 436 LIVTTVLEEPFVMFR--------KSDRTLYG-----------NDRFEG------------ 464

Query: 458 FCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPL 517
           +CIDLL +LA  + F+YE+ LV DGK+G Q+     +K +WNGM+ EL+  +AD+ VAPL
Sbjct: 465 YCIDLLKELAHILGFSYEIRLVEDGKYGAQD-----DKGQWNGMVKELIDHKADLAVAPL 519

Query: 518 TINNERAQYIEFSKPFKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVA 574
           TI + R + I+FSKPF   G++IL +K  P  T   + SF+ P    +W+ V L+   V+
Sbjct: 520 TITHVREKAIDFSKPFMTLGVSILYRK--PNGTNPSVFSFLNPLSPDIWMYVLLAYLGVS 577

Query: 575 VMLYLLDRFSPFGRFKVN----SEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSAR 630
            +L+++ RFSP+  +  +      E  E+  TL ++ WF  G L+  G  E  P++ S R
Sbjct: 578 CVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQG-SELMPKALSTR 636

Query: 631 ILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVD 690
           I+G +W  F +II++SYTANLAAFL ++R E  I   +D   +    K  Y  VK  +  
Sbjct: 637 IIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVKDGATM 693

Query: 691 IYFRRQVELST---MYRHME-------KHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA 740
            +F++  ++ST   M+  M        K+N E    A+ A      +A + +S  +E+  
Sbjct: 694 TFFKKS-KISTFEKMWAFMSSKPSALVKNNEEGIQRALTAD-----YALLMESTTIEYVT 747

Query: 741 SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDS 800
            + C+L   G L    G+GIG    SP++  ++++IL+  E   +  + + W R   C  
Sbjct: 748 QRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPE 807

Query: 801 RSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWR 859
             N  A+ L  + + G+F+++A G+V  + +   E  YK  K A R+Q        +  R
Sbjct: 808 EENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIR 867

Query: 860 KNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
            +L  ++  + +P P       A+ + + +   RR   KD+
Sbjct: 868 FSLTCQRRVKHKPQPPMMVKTDAVIN-MHTFNDRRLPGKDS 907


>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
           sapiens]
          Length = 906

 Score =  244 bits (624), Expect = 2e-64
 Identities = 197/751 (26%), Positives = 350/751 (46%), Gaps = 115/751 (15%)

Query: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEER-ESKAEKVLQFDPGTKNVTALLMEAKELEA 216
           Y W   + +   D      QK L+T  E+  +  A  +L      +    L  + ++ + 
Sbjct: 140 YKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTE--EGYRMLFQDLEKKKE 197

Query: 217 RVIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLIN 273
           R++++    +    +      L   G GY +++   G  +I  N  + +   + G QL+N
Sbjct: 198 RLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVN 257

Query: 274 ----------------------------GKNESAHISDAVGVVAQAVHELLEKENITDPP 305
                                        K  SA   D V V+A+A   L  ++ I    
Sbjct: 258 YTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSL-RRQRIDISR 316

Query: 306 RG----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
           RG    C+ N  + W  G   +R L   ++ +G+TG V+FNE G R      ++ +++  
Sbjct: 317 RGNAGDCLANPAVPWGQGIDIQRALQQVRF-EGLTGNVQFNEKGRRTNYTLHVIEMKHDG 375

Query: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLK---IVTIHQEPFVYVKPTLSD 417
           + ++G +N       D K + P     +  G   S + +   + TI ++P+V +K   + 
Sbjct: 376 IRKIGYWN------EDDKFV-PAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQ 428

Query: 418 GTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVH 477
                                      G+ R+       G+C++L  ++A+ + ++Y + 
Sbjct: 429 -------------------------FEGNDRYE------GYCVELAAEIAKHVGYSYRLE 457

Query: 478 LVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQG 537
           +V+DGK+G ++     + K WNGM+GEL+ G+AD+ VAPLTI   R + I+FSKPF   G
Sbjct: 458 IVSDGKYGARD----PDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLG 513

Query: 538 LTILVKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPF---------G 587
           ++I++KK +  +  + SF+ P    +W+ +  +   V+V+L+L+ RFSP+         G
Sbjct: 514 ISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEG 573

Query: 588 RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASY 647
           R +  S++  E    + +++WFS G  +  G  + +PRS S RI+G VW  F +II++SY
Sbjct: 574 RDQTTSDQSNE--FGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSY 630

Query: 648 TANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRH 705
           TANLAAFL ++R    I    D   +    +  Y T++  S   +FRR        M+ +
Sbjct: 631 TANLAAFLTVERMVSPIESAEDLAKQT---EIAYGTLEAGSTKEFFRRSKIAVFEKMWTY 687

Query: 706 MEKHN----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFG 759
           M+         +  E +  VR +K  +A++ +S + E+ E  + CD +  G      G+G
Sbjct: 688 MKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG 747

Query: 760 IGMRKDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDS----RSNAPATLTFENMA 814
           I   K S  +  V+L++LK +E G ++ L +K W    EC S      +  + L+  N+A
Sbjct: 748 IATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVA 807

Query: 815 GVFMLVAGGIVAGIFLIFIEIAYKRHKDARR 845
           GVF ++ GG+   + +  IE  YK   +++R
Sbjct: 808 GVFYILIGGLGLAMLVALIEFCYKSRSESKR 838


>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
           sapiens]
          Length = 906

 Score =  244 bits (622), Expect = 4e-64
 Identities = 197/751 (26%), Positives = 349/751 (46%), Gaps = 115/751 (15%)

Query: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEER-ESKAEKVLQFDPGTKNVTALLMEAKELEA 216
           Y W   + +   D      QK L+T  E+  +  A  +L      +    L  + ++ + 
Sbjct: 140 YKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTE--EGYRMLFQDLEKKKE 197

Query: 217 RVIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLIN 273
           R++++    +    +      L   G GY +++   G  +I  N  + +   + G QL+N
Sbjct: 198 RLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVN 257

Query: 274 ----------------------------GKNESAHISDAVGVVAQAVHELLEKENITDPP 305
                                        K  SA   D V V+A+A   L  ++ I    
Sbjct: 258 YTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSL-RRQRIDISR 316

Query: 306 RG----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK 360
           RG    C+ N  + W  G   +R L   ++ +G+TG V+FNE G R      ++ +++  
Sbjct: 317 RGNAGDCLANPAVPWGQGIDIQRALQQVRF-EGLTGNVQFNEKGRRTNYTLHVIEMKHDG 375

Query: 361 LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLK---IVTIHQEPFVYVKPTLSD 417
           + ++G +N       D K + P     +  G   S + +   + TI ++P+V +K   + 
Sbjct: 376 IRKIGYWN------EDDKFV-PAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQ 428

Query: 418 GTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVH 477
                                      G+ R+       G+C++L  ++A+ + ++Y + 
Sbjct: 429 -------------------------FEGNDRYE------GYCVELAAEIAKHVGYSYRLE 457

Query: 478 LVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQG 537
           +V+DGK+G ++     + K WNGM+GEL+ G+AD+ VAPLTI   R + I+FSKPF   G
Sbjct: 458 IVSDGKYGARD----PDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLG 513

Query: 538 LTILVKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPF---------G 587
           ++I++KK +  +  + SF+ P    +W+ +  +   V+V+L+L+ RFSP+         G
Sbjct: 514 ISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEG 573

Query: 588 RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASY 647
           R +  S++  E    + +++WFS G  +  G  + +PRS S RI+G VW  F +II++SY
Sbjct: 574 RDQTTSDQSNE--FGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSY 630

Query: 648 TANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRH 705
           TANLAAFL ++R    I    D   +    +  Y T++  S   +FRR        M+ +
Sbjct: 631 TANLAAFLTVERMVSPIESAEDLAKQT---EIAYGTLEAGSTKEFFRRSKIAVFEKMWTY 687

Query: 706 MEKHN----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFG 759
           M+         +  E +  VR +K  +A++ +S + E+ E  + CD +  G      G+G
Sbjct: 688 MKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG 747

Query: 760 IGMRKDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNA----PATLTFENMA 814
           I   K S  +  V+L++LK  E G ++ L  K W    EC S+ +      + L+  N+A
Sbjct: 748 IATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVA 807

Query: 815 GVFMLVAGGIVAGIFLIFIEIAYKRHKDARR 845
           GVF ++ GG+   + +  IE  YK   +++R
Sbjct: 808 GVFYILIGGLGLAMLVALIEFCYKSRSESKR 838


>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
           [Homo sapiens]
          Length = 1043

 Score =  243 bits (621), Expect = 5e-64
 Identities = 198/728 (27%), Positives = 342/728 (46%), Gaps = 71/728 (9%)

Query: 231 VYRAAAMLNMTGSGYVWLVGEREISGNALRYA--PDGILGLQLINGKNESAHISDAVGVV 288
           + RA  +L     G  WL+G   +   AL  A  P G+L L  +      A I D V +V
Sbjct: 242 IARARRVLEAVPPGPHWLLGT-PLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLV 300

Query: 289 AQAVHELLE---KENITDPPRGCVGNTNIWKTGP-----LFKRVLMSSKYADGVTGRVEF 340
           A+A+    +   K  +   P  C    ++   GP        R L ++ +  G TG V  
Sbjct: 301 ARALGSAAQVQPKRALLPAPVNC---GDLQPAGPESPGRFLARFLANTSF-QGRTGPVWV 356

Query: 341 NEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP---RGYQMSTR 397
                   + +  +    R       +       + +  + PGG + +P   +G Q+  +
Sbjct: 357 TGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPK 416

Query: 398 LKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSP----------GSP 447
           L++VT+ + PFV+ +    DG C           +  +  G ND++           GS 
Sbjct: 417 LRVVTLLEHPFVFARDPDEDGQCPAG--------QLCLDPGTNDSATLDALFAALANGSA 468

Query: 448 RHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLS 507
              + +CCYG+CIDLL +LA    F +E++LV DGK+G            W G++G+LL+
Sbjct: 469 PRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALR------DGRWTGLVGDLLA 522

Query: 508 GQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVG 567
           G+A M V   +IN+ R+Q ++F+ PF    L I+V+     S + +FM P   + WL V 
Sbjct: 523 GRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVF 582

Query: 568 LSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSF 627
            ++H+ A+ L + +  SP+G              + SSA+   + +L    +    P+  
Sbjct: 583 AALHLTALFLTVYEWRSPYGL--TPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCP 640

Query: 628 SARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQS 687
           + R+L  +WA F +++++SYTANLAA +V D+  E ++GI+DP+L +P+  F + TV +S
Sbjct: 641 TGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWES 700

Query: 688 SVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEAS--QK 743
           S + Y ++      M+ HM +H+  +    +  +  +  KL+AFI D ++L++E S    
Sbjct: 701 SAEAYIKK--SFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDAD 758

Query: 744 CDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN 803
           C L+T G+ F   G+GIG+ ++SP   N+S  I +   +GF++ L   W +   C  R  
Sbjct: 759 CKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVF 818

Query: 804 A---PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDAR-RKQMQLAFAAVNVWR 859
           A      ++  + AG+F+L+  G+ + +     E A+ R    R RK  +L +     W 
Sbjct: 819 AVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQY-----WL 873

Query: 860 KNLQ--DRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVL 917
              Q   R      P+  K+ T  A  S      ++++  + T+  G + A         
Sbjct: 874 HTSQKIHRALNTEPPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKRA--------- 924

Query: 918 PRRAIERE 925
            RRA+++E
Sbjct: 925 -RRAVDKE 931


>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
          Length = 956

 Score =  241 bits (615), Expect = 2e-63
 Identities = 224/927 (24%), Positives = 395/927 (42%), Gaps = 125/927 (13%)

Query: 11  LLFSCSVARAACDPKIVNIGAVLST--------RKHEQMFREAVNQANKRHGSWKIQLNA 62
           +L    +   AC P  + I A+L          R    + +  +N+A +R G  K++++ 
Sbjct: 9   VLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDI 68

Query: 63  TSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLT 122
             +  + +  + A ++C+ L    V  +  S  P  +     + +S   G   +P     
Sbjct: 69  FELL-RDSEYETAETMCQILPKGVVAVLGPSSSPASS-----SIISNICGEKEVP----- 117

Query: 123 TRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEM-----MRVYSWNHIILLVSDDHEGRAAQ 177
               +  ++ +   F R      H S+    +     +  ++     L+ +        +
Sbjct: 118 -HFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLE 176

Query: 178 KRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAM 237
           K L   L  +++ + ++L     T++ T LL E ++ +   II+ A+   + T+   AA 
Sbjct: 177 KLLRQFLISKDTLSVRMLD---DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAE 233

Query: 238 LNMTGSGYVWLVGEREISGNALRYAPD---GILGLQLINGKN------------------ 276
           L M  + Y ++    E S   +    D    ILG  + N  +                  
Sbjct: 234 LGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENC 293

Query: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
                      SA + DAV  V  AV EL   + I   P  C G+  IW+ G      L 
Sbjct: 294 DHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSC-GSAQIWQHGTSLMNYLR 352

Query: 327 SSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGET 386
             +  +G+TG +EFN  G R      I+        Q+G ++    +  D  +       
Sbjct: 353 MVEL-EGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLY-----A 406

Query: 387 EKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGS 446
                   +T L + TI + P++ +K                         G +    G+
Sbjct: 407 SNISDTLFNTTLVVTTILENPYLMLK-------------------------GNHQEMEGN 441

Query: 447 PRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELL 506
            R+       GFC+D+L +LA  + F Y++ LV DG +G  E         W GM+GEL+
Sbjct: 442 DRYE------GFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGT-----WTGMVGELI 490

Query: 507 SGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST-LDSFMQPFQSTLWLL 565
           + +AD+ VA LTI  ER + I+FSKPF   G++IL +  + R     SF+ PF   +WL 
Sbjct: 491 ARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLF 550

Query: 566 VGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEE-----DALTLSSAMWFSWGVLLNSGIG 620
           + L+   V+ +L+L+ R +P+  +  +   +       +  +L +++WF  G  +  G  
Sbjct: 551 MLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQG-S 609

Query: 621 EGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFI 680
             APR+ S R +  VW  F +II++SYTANLAAFL + R +  I  ++D   +   +   
Sbjct: 610 TIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIE--- 666

Query: 681 YATVKQSSVDIYFRR------QVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSA 734
           Y T+   S   +F+       Q   + MY        +S  E I  V  N  +AF+ +S 
Sbjct: 667 YGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVL-NSNYAFLLEST 725

Query: 735 VLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVR 794
           + E+   + C+L   G L    G+GIGM   S ++    L+IL+  EN  +E L + W  
Sbjct: 726 MNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE 785

Query: 795 YQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYK-RHKDARR----KQM 848
             +C    +  A  L  EN+ G+F+++  G++  IF+  +E  +  RH +A      ++M
Sbjct: 786 GGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEM 845

Query: 849 QLAFAAVNVWRKNLQDRKSGRAEPDPK 875
                ++ + + ++  R+   A P P+
Sbjct: 846 VTELRSIILCQDSIHPRRRRAAVPPPR 872


>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
           precursor [Homo sapiens]
          Length = 883

 Score =  236 bits (602), Expect = 7e-62
 Identities = 184/616 (29%), Positives = 307/616 (49%), Gaps = 87/616 (14%)

Query: 275 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 329
           K  SA   DAV V+ +A   L  K+ I    RG    C+ N  + W  G   +R L   +
Sbjct: 294 KYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQ 352

Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 389
             +G++G ++F+++G R     +IM L+     ++G ++       D+ ++     TE P
Sbjct: 353 -VEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEV-----DKMVVTL---TELP 403

Query: 390 RGYQMS----TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPG 445
            G   S      + + TI + P+V +K                           ++   G
Sbjct: 404 SGNDTSGLENKTVVVTTILESPYVMMKKN-------------------------HEMLEG 438

Query: 446 SPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGEL 505
           + R+       G+C+DL  ++A+   F Y++ +V DGK+G ++    ++ K WNGM+GEL
Sbjct: 439 NERYE------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD----ADTKIWNGMVGEL 488

Query: 506 LSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWL 564
           + G+AD+ +APLTI   R + I+FSKPF   G++I++KK +  +  + SF+ P    +W+
Sbjct: 489 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548

Query: 565 LVGLSVHVVAVMLYLLDRFSPF---------GRFKVNSEEEEEDALTLSSAMWFSWGVLL 615
            +  +   V+V+L+L+ RFSP+         GR   +SE   E    + +++WFS G  +
Sbjct: 549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNE--FGIFNSLWFSLGAFM 606

Query: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
             G  + +PRS S RI+G VW  F +II++SYTANLAAFL ++R    I    D    + 
Sbjct: 607 RQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED---LSK 662

Query: 676 SDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHA 728
             +  Y T+   S   +FRR        M+ +M          + AE +  VR +K  +A
Sbjct: 663 QTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA 722

Query: 729 FIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMED 787
           ++ +S + E+ E  + CD +  G      G+GI   K S  +  V+L++LK +E G ++ 
Sbjct: 723 YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDK 782

Query: 788 L-DKTWVRYQEC-----DSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHK 841
           L +K W    EC     DS+    A L+  N+AGVF ++ GG+   + +  IE  YK   
Sbjct: 783 LKNKWWYDKGECGSGGGDSKEKTSA-LSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRA 841

Query: 842 DARRKQMQLAFAAVNV 857
           +A+R  M++A  A N+
Sbjct: 842 EAKR--MKVAKNAQNI 855


>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
           sapiens]
          Length = 836

 Score =  235 bits (599), Expect = 2e-61
 Identities = 181/615 (29%), Positives = 306/615 (49%), Gaps = 85/615 (13%)

Query: 275 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 329
           K  SA   DAV V+ +A   L  K+ I    RG    C+ N  + W  G   +R L   +
Sbjct: 247 KYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQ 305

Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 389
             +G++G ++F+++G R     +IM L+     ++G ++       D+ ++     TE P
Sbjct: 306 -VEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEV-----DKMVVTL---TELP 356

Query: 390 RGYQMS----TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPG 445
            G   S      + + TI + P+V +K                           ++   G
Sbjct: 357 SGNDTSGLENKTVVVTTILESPYVMMKKN-------------------------HEMLEG 391

Query: 446 SPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGEL 505
           + R+       G+C+DL  ++A+   F Y++ +V DGK+G ++    ++ K WNGM+GEL
Sbjct: 392 NERYE------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD----ADTKIWNGMVGEL 441

Query: 506 LSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWL 564
           + G+AD+ +APLTI   R + I+FSKPF   G++I++KK +  +  + SF+ P    +W+
Sbjct: 442 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 501

Query: 565 LVGLSVHVVAVMLYLLDRFSPF---------GRFKVNSEEEEEDALTLSSAMWFSWGVLL 615
            +  +   V+V+L+L+ RFSP+         GR   +SE   E    + +++WFS G  +
Sbjct: 502 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNE--FGIFNSLWFSLGAFM 559

Query: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
             G  + +PRS S RI+G VW  F +II++SYTANLAAFL ++R    I    D    + 
Sbjct: 560 RQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED---LSK 615

Query: 676 SDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHA 728
             +  Y T+   S   +FRR        M+ +M          + AE +  VR +K  +A
Sbjct: 616 QTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA 675

Query: 729 FIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMED 787
           ++ +S + E+ E  + CD +  G      G+GI   K S  +  V+L++LK  E G ++ 
Sbjct: 676 YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDK 735

Query: 788 L-DKTWVRYQECDSRSNA----PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKD 842
           L +K W    EC ++ +      + L+  N+AGVF ++ GG+   + +  IE  YK   +
Sbjct: 736 LKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAE 795

Query: 843 ARRKQMQLAFAAVNV 857
           A+R  M++A  A N+
Sbjct: 796 AKR--MKVAKNAQNI 808


>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
           precursor [Homo sapiens]
          Length = 883

 Score =  235 bits (599), Expect = 2e-61
 Identities = 181/615 (29%), Positives = 306/615 (49%), Gaps = 85/615 (13%)

Query: 275 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 329
           K  SA   DAV V+ +A   L  K+ I    RG    C+ N  + W  G   +R L   +
Sbjct: 294 KYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQ 352

Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 389
             +G++G ++F+++G R     +IM L+     ++G ++       D+ ++     TE P
Sbjct: 353 -VEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEV-----DKMVVTL---TELP 403

Query: 390 RGYQMS----TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPG 445
            G   S      + + TI + P+V +K                           ++   G
Sbjct: 404 SGNDTSGLENKTVVVTTILESPYVMMKKN-------------------------HEMLEG 438

Query: 446 SPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGEL 505
           + R+       G+C+DL  ++A+   F Y++ +V DGK+G ++    ++ K WNGM+GEL
Sbjct: 439 NERYE------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD----ADTKIWNGMVGEL 488

Query: 506 LSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWL 564
           + G+AD+ +APLTI   R + I+FSKPF   G++I++KK +  +  + SF+ P    +W+
Sbjct: 489 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548

Query: 565 LVGLSVHVVAVMLYLLDRFSPF---------GRFKVNSEEEEEDALTLSSAMWFSWGVLL 615
            +  +   V+V+L+L+ RFSP+         GR   +SE   E    + +++WFS G  +
Sbjct: 549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNE--FGIFNSLWFSLGAFM 606

Query: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
             G  + +PRS S RI+G VW  F +II++SYTANLAAFL ++R    I    D    + 
Sbjct: 607 RQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED---LSK 662

Query: 676 SDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHA 728
             +  Y T+   S   +FRR        M+ +M          + AE +  VR +K  +A
Sbjct: 663 QTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA 722

Query: 729 FIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMED 787
           ++ +S + E+ E  + CD +  G      G+GI   K S  +  V+L++LK  E G ++ 
Sbjct: 723 YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDK 782

Query: 788 L-DKTWVRYQECDSRSNA----PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKD 842
           L +K W    EC ++ +      + L+  N+AGVF ++ GG+   + +  IE  YK   +
Sbjct: 783 LKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAE 842

Query: 843 ARRKQMQLAFAAVNV 857
           A+R  M++A  A N+
Sbjct: 843 AKR--MKVAKNAQNI 855


>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
           precursor [Homo sapiens]
          Length = 894

 Score =  223 bits (568), Expect = 6e-58
 Identities = 182/750 (24%), Positives = 332/750 (44%), Gaps = 105/750 (14%)

Query: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEAR 217
           Y W   + L   +      Q  +E  ++       + +      +    ++ E    + +
Sbjct: 156 YKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEK 215

Query: 218 VIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLING 274
             ++    +   T+     +L     GY +++   G  +I    + +    I G Q++N 
Sbjct: 216 RYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNN 275

Query: 275 KNE----------------------------SAHISDAVGVVAQAVHELLEKENITDPPR 306
           +N                             SA   DA+ V+A+A    L ++ +    R
Sbjct: 276 ENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFR-YLRRQRVDVSRR 334

Query: 307 G----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKL 361
           G    C+ N  + W  G   +R L   +   G+TG ++F+  G R      +  ++    
Sbjct: 335 GSAGDCLANPAVPWSQGIDIERALKMVQ-VQGMTGNIQFDTYGRRTNYTIDVYEMKVSGS 393

Query: 362 VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCK 421
            + G +N       +R + +   +         +  + + TI + P+V  K         
Sbjct: 394 RKAGYWN-----EYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKN------- 441

Query: 422 EEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVAD 481
                             ++   G+ R+       G+C+DL  ++A+ +   Y++ +V D
Sbjct: 442 ------------------HEQLEGNERYE------GYCVDLAYEIAKHVRIKYKLSIVGD 477

Query: 482 GKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTIL 541
           GK+G ++       K WNGM+GEL+ G+AD+ VAPLTI   R + I+FSKPF   G++I+
Sbjct: 478 GKYGARD----PETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIM 533

Query: 542 VKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
           +KK +  +  + SF+ P    +W+ +  +   V+V+L+L+ RFSP+     ++ EE  D 
Sbjct: 534 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP 593

Query: 601 LT---------LSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANL 651
            +         + +++WFS G  +  G  + +PRS S RI+G VW  F +II++SYTANL
Sbjct: 594 QSPPDPPNEFGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANL 652

Query: 652 AAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKH 709
           AAFL ++R    I    D   +    +  Y T+   S   +FRR        M+ +M+  
Sbjct: 653 AAFLTVERMVSPIESAEDLAKQT---EIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 709

Query: 710 N----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMR 763
                 ++ A+ +  VR +K   AF+ +S + E+ E  + CD +  G      G+G+   
Sbjct: 710 EPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 769

Query: 764 KDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDS----RSNAPATLTFENMAGVFM 818
           K S     V+L++LK +E G ++ L +K W    EC S      +  + L+  N+AGVF 
Sbjct: 770 KGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFY 829

Query: 819 LVAGGIVAGIFLIFIEIAYKRHKDARRKQM 848
           ++ GG+   + +  IE  YK   +++R ++
Sbjct: 830 ILVGGLGLAMMVALIEFCYKSRAESKRMKL 859


>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
           precursor [Homo sapiens]
          Length = 894

 Score =  222 bits (566), Expect = 1e-57
 Identities = 181/750 (24%), Positives = 332/750 (44%), Gaps = 105/750 (14%)

Query: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEAR 217
           Y W   + L   +      Q  +E  ++       + +      +    ++ E    + +
Sbjct: 156 YKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEK 215

Query: 218 VIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLING 274
             ++    +   T+     +L     GY +++   G  +I    + +    I G Q++N 
Sbjct: 216 RYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNN 275

Query: 275 KNE----------------------------SAHISDAVGVVAQAVHELLEKENITDPPR 306
           +N                             SA   DA+ V+A+A    L ++ +    R
Sbjct: 276 ENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFR-YLRRQRVDVSRR 334

Query: 307 G----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKL 361
           G    C+ N  + W  G   +R L   +   G+TG ++F+  G R      +  ++    
Sbjct: 335 GSAGDCLANPAVPWSQGIDIERALKMVQ-VQGMTGNIQFDTYGRRTNYTIDVYEMKVSGS 393

Query: 362 VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCK 421
            + G +N       +R + +   +         +  + + TI + P+V  K         
Sbjct: 394 RKAGYWN-----EYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKN------- 441

Query: 422 EEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVAD 481
                             ++   G+ R+       G+C+DL  ++A+ +   Y++ +V D
Sbjct: 442 ------------------HEQLEGNERYE------GYCVDLAYEIAKHVRIKYKLSIVGD 477

Query: 482 GKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTIL 541
           GK+G ++       K WNGM+GEL+ G+AD+ VAPLTI   R + I+FSKPF   G++I+
Sbjct: 478 GKYGARD----PETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIM 533

Query: 542 VKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600
           +KK +  +  + SF+ P    +W+ +  +   V+V+L+L+ RFSP+     ++ EE  D 
Sbjct: 534 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP 593

Query: 601 LT---------LSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANL 651
            +         + +++WFS G  +  G  + +PRS S RI+G VW  F +II++SYTANL
Sbjct: 594 QSPPDPPNEFGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANL 652

Query: 652 AAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKH 709
           AAFL ++R    I    D   +    +  Y T+   S   +FRR        M+ +M+  
Sbjct: 653 AAFLTVERMVSPIESAEDLAKQT---EIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 709

Query: 710 N----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMR 763
                 ++ A+ +  VR +K   AF+ +S + E+ E  + CD +  G      G+G+   
Sbjct: 710 EPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 769

Query: 764 KDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNA----PATLTFENMAGVFM 818
           K S     V+L++LK  E G ++ L +K W    EC ++ +      + L+  N+AGVF 
Sbjct: 770 KGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFY 829

Query: 819 LVAGGIVAGIFLIFIEIAYKRHKDARRKQM 848
           ++ GG+   + +  IE  YK   +++R ++
Sbjct: 830 ILVGGLGLAMMVALIEFCYKSRAESKRMKL 859


>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
           precursor [Homo sapiens]
          Length = 884

 Score =  218 bits (556), Expect = 2e-56
 Identities = 171/602 (28%), Positives = 290/602 (48%), Gaps = 75/602 (12%)

Query: 275 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 329
           K  SA   D V V+A+    L  ++ I    RG    C+ N    W  G   +R L   +
Sbjct: 295 KYTSALTYDGVLVMAETFRSL-RRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVR 353

Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 389
              G+TG V+F+  G R      +  L++    +VG +N    +   + +   G +T   
Sbjct: 354 I-QGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAI 412

Query: 390 RGYQMSTRLKIVTIHQEPFVYVKPT--LSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSP 447
                +  + + TI + P+V  K    + +G  K E                        
Sbjct: 413 E----NRTVVVTTIMESPYVMYKKNHEMFEGNDKYE------------------------ 444

Query: 448 RHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLS 507
                    G+C+DL  ++A+ +   Y++ +V DGK+G ++    ++ K WNGM+GEL+ 
Sbjct: 445 ---------GYCVDLASEIAKHIGIKYKIAIVPDGKYGARD----ADTKIWNGMVGELVY 491

Query: 508 GQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWLLV 566
           G+A++ +APLTI   R + I+FSKPF   G++I++KK +  +  + SF+ P    +W+ +
Sbjct: 492 GKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI 551

Query: 567 GLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEE-------DALTLSSAMWFSWGVLLNSGI 619
             +   V+V+L+L+ RFSP+       E+ +E       +   + +++WFS G  +  G 
Sbjct: 552 VFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGC 611

Query: 620 GEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKF 679
            + +PRS S RI+G VW  F +II++SYTANLAAFL ++R    I    D   +    + 
Sbjct: 612 -DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQT---EI 667

Query: 680 IYATVKQSSVDIYFRRQ-----VELSTMYRHMEKHNY-ESAAEAIQAVRDNK-LHAFIWD 732
            Y T+   S   +FRR       ++ T  R  E   +  + AE +  VR +K   AF+ +
Sbjct: 668 AYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLE 727

Query: 733 SAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDL-DK 790
           S + E+ E  + CD +  G      G+G+   K S     V+L++LK +E G ++ L +K
Sbjct: 728 STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK 787

Query: 791 TWVRYQECDS----RSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRK 846
            W    EC S      +  + L+  N+AGVF ++ GG+   + +  IE  YK   +A+R 
Sbjct: 788 WWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRM 847

Query: 847 QM 848
           ++
Sbjct: 848 KV 849


>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
           precursor [Homo sapiens]
          Length = 902

 Score =  218 bits (555), Expect = 2e-56
 Identities = 185/641 (28%), Positives = 308/641 (48%), Gaps = 79/641 (12%)

Query: 275 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 329
           K  SA   D V V+A+    L  ++ I    RG    C+ N    W  G   +R L   +
Sbjct: 295 KYTSALTYDGVLVMAETFRSL-RRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVR 353

Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 389
              G+TG V+F+  G R      +  L++    +VG +N    +   + +   G +T   
Sbjct: 354 I-QGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAI 412

Query: 390 RGYQMSTRLKIVTIHQEPFVYVKPT--LSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSP 447
                +  + + TI + P+V  K    + +G  K E                        
Sbjct: 413 E----NRTVVVTTIMESPYVMYKKNHEMFEGNDKYE------------------------ 444

Query: 448 RHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLS 507
                    G+C+DL  ++A+ +   Y++ +V DGK+G ++    ++ K WNGM+GEL+ 
Sbjct: 445 ---------GYCVDLASEIAKHIGIKYKIAIVPDGKYGARD----ADTKIWNGMVGELVY 491

Query: 508 GQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWLLV 566
           G+A++ +APLTI   R + I+FSKPF   G++I++KK +  +  + SF+ P    +W+ +
Sbjct: 492 GKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI 551

Query: 567 GLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEE-------DALTLSSAMWFSWGVLLNSGI 619
             +   V+V+L+L+ RFSP+       E+ +E       +   + +++WFS G  +  G 
Sbjct: 552 VFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGC 611

Query: 620 GEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKF 679
            + +PRS S RI+G VW  F +II++SYTANLAAFL ++R    I    D   +    + 
Sbjct: 612 -DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQT---EI 667

Query: 680 IYATVKQSSVDIYFRRQ-----VELSTMYRHMEKHNY-ESAAEAIQAVRDNK-LHAFIWD 732
            Y T+   S   +FRR       ++ T  R  E   +  + AE +  VR +K   AF+ +
Sbjct: 668 AYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLE 727

Query: 733 SAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDL-DK 790
           S + E+ E  + CD +  G      G+G+   K S     V+L++LK  E G ++ L +K
Sbjct: 728 STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGTPVNLAVLKLSEAGVLDKLKNK 787

Query: 791 TWVRYQEC---DSRS-NAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRK 846
            W    EC   DS S +  + L+  N+AGVF ++ GG+   + +  IE  YK   +A+R 
Sbjct: 788 WWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRM 847

Query: 847 QMQLAFAAVNVWRKNLQDR--KSGRA-EPD-PKKKATFRAI 883
           ++  + A  N  R ++     ++GR   PD PK   T  AI
Sbjct: 848 KLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAI 888


>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
           sapiens]
          Length = 1009

 Score =  203 bits (517), Expect = 5e-52
 Identities = 167/639 (26%), Positives = 291/639 (45%), Gaps = 89/639 (13%)

Query: 269 LQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPR-GCVG-NTNIWKTGPLFKRVLM 326
           LQ++   N   ++ D+V ++A A H  LE           C+  +T  W  G      + 
Sbjct: 313 LQMLQISN--LYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIK 370

Query: 327 SSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWP---- 382
              +  G+TG +EF ED    +  + I+            Y+ T      +   W     
Sbjct: 371 KG-HITGLTGVMEFREDSSNPYVQFEILGTT---------YSETFGKDMRKLATWDSEKG 420

Query: 383 --GGETEKPRGYQMS-TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGP 439
             G   E+P G ++    LK+VT+ +EPFV V   +                        
Sbjct: 421 LNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENIL----------------------- 457

Query: 440 NDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWN 499
                G P+        GF ID+L  LA+ + F YE++   DG++G Q  ++N++   WN
Sbjct: 458 -----GQPKRYK-----GFSIDVLDALAKALGFKYEIYQAPDGRYGHQ--LHNTS---WN 502

Query: 500 GMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQ 559
           GM+GEL+S +AD+ ++ +TI  ER   ++FSK +    + IL+KK   + ++ S   PF 
Sbjct: 503 GMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFD 562

Query: 560 STLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGI 619
             +W  +  ++ VV V++++L+R     R +  ++     + TL SA+W  +G  +  G 
Sbjct: 563 FAVWACIAAAIPVVGVLIFVLNRIQAV-RAQSAAQPRPSASATLHSAIWIVYGAFVQQG- 620

Query: 620 GEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKF 679
           GE +  S + RI+   W  F +I+ +SYTANLAAFL + R +  I    D    +   + 
Sbjct: 621 GESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQD---LSKQVEM 677

Query: 680 IYATVKQSSVDIYFR--------RQVELSTMYRHMEKHN-----YESAAEAIQAVRDNKL 726
            Y TV+ S+V  YFR        +    + ++R + K+        S +E I+  +    
Sbjct: 678 SYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGN- 736

Query: 727 HAFIWDSAVLEFEA--SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGF 784
           +AF+WD AV+E+ A     C +   G      G+GI ++  SP++   S  IL+  + G 
Sbjct: 737 YAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGD 796

Query: 785 MEDL-DKTWVRYQECDSRSNAPA-----TLTFENMAGVFMLVAGGIVAGIFLIFIEI--- 835
           ++ L  K W     CD  S+A A     +L   + AGVF ++A G++    +  +E+   
Sbjct: 797 LDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWN 856

Query: 836 AYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDP 874
           + + H++  ++  ++    V+    +L D      +  P
Sbjct: 857 SNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISP 895


>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
          Length = 1007

 Score =  198 bits (503), Expect = 2e-50
 Identities = 220/924 (23%), Positives = 392/924 (42%), Gaps = 153/924 (16%)

Query: 6   LLTLALLFSCSVARAACDPKIVNIGAVL--STRKHEQMFREAVNQANKRHGSWKIQLNAT 63
           LL L++ +S +   A  D  I++IGA+   S +K +++FR AV   N+     + +    
Sbjct: 7   LLVLSVWWSRTWDSANAD-SIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITF 65

Query: 64  SVTHKP--NAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGL 121
           SVT     N  Q     CE L++  + A++ S   T     +   +   A    IP L +
Sbjct: 66  SVTFVDGNNPFQAVQEACE-LMNQGILALVSSIGCT-----SAGSLQSLADAMHIPHLFI 119

Query: 122 TTRMSIYSDKSIHLS-------FLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR 174
               +        L+       +  +V P  +   V   ++  Y+W   I+    +++ R
Sbjct: 120 QRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIR 179

Query: 175 AAQKRLETL--------LEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASED 226
             Q+ L+ +        L++ E+   K++     T  +  L      L   +++++ +  
Sbjct: 180 GIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPAT- 238

Query: 227 DAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI-------------- 272
            A +        N+      W++   EI+   ++      +G   I              
Sbjct: 239 -AKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQR 297

Query: 273 ---------------------NGKNESAHISDAVGVVAQAVHELLEKENITDPPR-GCVG 310
                                N +  + +I D V ++A A H+ LE           C+ 
Sbjct: 298 CFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIR 357

Query: 311 -NTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQ-----NRKLVQV 364
            N+  W+ G      +     + G+TG +EF E+G     ++ I+         R + ++
Sbjct: 358 KNSKPWQGGRSMLETIKKGGVS-GLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKL 416

Query: 365 GIYNGTHVIPNDRKIIWPGGETEKPRGYQM-STRLKIVTIHQEPFVYVKPTLSDGTCKEE 423
           G +N    +         G  T+K     M    L++VT+ +EPFV V            
Sbjct: 417 GCWNPVTGLN--------GSLTDKKLENNMRGVVLRVVTVLEEPFVMVSEN--------- 459

Query: 424 FTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGK 483
             V G P K                        GF ID+L  L+  + F YE+++  D K
Sbjct: 460 --VLGKPKKY----------------------QGFSIDVLDALSNYLGFNYEIYVAPDHK 495

Query: 484 FGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVK 543
           +G+ +         WNG++GEL+  +AD+ ++ LTI  +R   ++F+  +    + +L++
Sbjct: 496 YGSPQEDGT-----WNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550

Query: 544 KEIPRSTLDSF--MQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL 601
           +     T+D F  + PF  +LW  +  +V +V +++YLL+  +P  R ++ S      + 
Sbjct: 551 R--AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP-PRLQMGS----MTST 603

Query: 602 TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPE 661
           TL ++MWF +G  +  G GE    + + R++   W  FA+I+++SYTANLAAFL + R E
Sbjct: 604 TLYNSMWFVYGSFVQQG-GEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIE 662

Query: 662 ERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ----VELSTMYRHM---------EK 708
             I  + D    +   +  Y TV  S+V  + R +     E  +MY  M          +
Sbjct: 663 SSIQSLQD---LSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSE 719

Query: 709 HNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVTTGELFFRSGFGIGMRKDS 766
           +N   +   IQ V+    +AF+WD+AVLE+ A     C   T G      G+GI ++  S
Sbjct: 720 NNVLESQAGIQKVKYGN-YAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGS 778

Query: 767 PWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNAP-----ATLTFENMAGVFMLV 820
           P++   S  IL+  +NG M+ L  K W +  +CD  S+         L  ++ AGVF ++
Sbjct: 779 PYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCIL 838

Query: 821 AGGIVAGIFLIFIEIAYKRHKDAR 844
           A GIV   F+  +E  + + K +R
Sbjct: 839 AAGIVLSCFIAMLETWWNKRKGSR 862


>gi|37577159 calcium-sensing receptor [Homo sapiens]
          Length = 1078

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 38/158 (24%), Positives = 76/158 (48%), Gaps = 6/158 (3%)

Query: 105 TPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHII 164
           T V+   G + IP +   +   + S+K+   SFLRT+P   HQ++   +++  + WN + 
Sbjct: 151 TAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVG 210

Query: 165 LLVSDDHEGRAAQKRLETLLEERE---SKAEKVLQFDPGTKNVTALLMEAKELEARVIIL 221
            + +DD  GR   ++     EER+     +E + Q+    + +  ++   +   A+VI++
Sbjct: 211 TIAADDDYGRPGIEKFREEAEERDICIDFSELISQYS-DEEEIQHVVEVIQNSTAKVIVV 269

Query: 222 SASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNAL 259
            +S  D   + +     N+TG   +WL  E   S + +
Sbjct: 270 FSSGPDLEPLIKEIVRRNITGK--IWLASEAWASSSLI 305



 Score = 30.8 bits (68), Expect = 6.2
 Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 12/71 (16%)

Query: 330 YADGVTGRVEFNEDGDRKFANYSIMNL----QNRKLV--QVGIYN-----GTHVIPNDRK 378
           + + +  +V F+E GD    NYSI+N     ++  +V  +VG YN     G  +  N+ K
Sbjct: 469 FTNNMGEQVTFDECGDL-VGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK 527

Query: 379 IIWPGGETEKP 389
           I+W G   E P
Sbjct: 528 ILWSGFSREVP 538


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,933,231
Number of Sequences: 37866
Number of extensions: 1533278
Number of successful extensions: 3761
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 3542
Number of HSP's gapped (non-prelim): 85
length of query: 938
length of database: 18,247,518
effective HSP length: 112
effective length of query: 826
effective length of database: 14,006,526
effective search space: 11569390476
effective search space used: 11569390476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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