Search of human proteins with 110349763

Search of human proteins with 110349763

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
         (397 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     813   0.0  
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       808   0.0  
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     691   0.0  
gi|4758968 cytohesin 3 [Homo sapiens]                                 689   0.0  
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       686   0.0  
gi|7019505 cytohesin 4 [Homo sapiens]                                 580   e-166
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   198   6e-51
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...   194   9e-50
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]      161   8e-40
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]       161   8e-40
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                 156   3e-38
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   149   4e-36
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]       147   1e-35
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]       147   1e-35
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]      117   2e-26
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...   113   3e-25
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...   113   3e-25
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]    112   8e-25
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]    111   1e-24
gi|48928044 F-box only protein 8 [Homo sapiens]                        85   1e-16
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    63   5e-10
gi|50234893 pleckstrin homology domain containing, family A (pho...    61   2e-09
gi|31377720 pleckstrin homology domain containing, family A (pho...    61   2e-09
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit...    57   4e-08
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ...    56   7e-08
gi|217416392 pleckstrin homology domain containing, family H (wi...    55   1e-07
gi|24432056 hypothetical protein LOC144717 [Homo sapiens]              55   1e-07
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa...    54   3e-07
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]        53   4e-07
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]       53   4e-07

>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  813 bits (2099), Expect = 0.0
 Identities = 397/397 (100%), Positives = 397/397 (100%)

Query: 1   MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM 60
           MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM
Sbjct: 1   MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM 60

Query: 61  QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120
           QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD
Sbjct: 61  QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF 180
           EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF 180

Query: 181 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK 240
           QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK
Sbjct: 181 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK 240

Query: 241 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEP 300
           NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEP
Sbjct: 241 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEP 300

Query: 301 RGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPT 360
           RGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPT
Sbjct: 301 RGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPT 360

Query: 361 PEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH 397
           PEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
Sbjct: 361 PEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH 397


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  808 bits (2087), Expect = 0.0
 Identities = 397/398 (99%), Positives = 397/398 (99%), Gaps = 1/398 (0%)

Query: 1   MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM 60
           MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM
Sbjct: 1   MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM 60

Query: 61  QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120
           QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD
Sbjct: 61  QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF 180
           EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF 180

Query: 181 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK 240
           QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK
Sbjct: 181 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK 240

Query: 241 NEPFKIPEDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTDKE 299
           NEPFKIPEDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTDKE
Sbjct: 241 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKE 300

Query: 300 PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP 359
           PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP
Sbjct: 301 PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP 360

Query: 360 TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH 397
           TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
Sbjct: 361 TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH 398


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  691 bits (1783), Expect = 0.0
 Identities = 328/394 (83%), Positives = 365/394 (92%)

Query: 3   EDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQR 62
           ED  Y P DLT EER ELENIRRRKQELL +IQRL++E++E  +E+E L + E  K +QR
Sbjct: 2   EDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQR 61

Query: 63  NKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEF 122
           N+++AMGRKKFNMDPKKGIQFL+EN+LL+NT E+IA+FLYKGEGLNKTAIGDYLGER+E 
Sbjct: 62  NRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREEL 121

Query: 123 NIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQS 182
           N+ VLHAFV+LHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC CN GVFQS
Sbjct: 122 NLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQS 181

Query: 183 TDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNE 242
           TDTCYVLSFA+IMLNTSLHNPNV+DKP +ERF+AMNRGIN+GGDLPEELLRNLY+SI+NE
Sbjct: 182 TDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNE 241

Query: 243 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRG 302
           PFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRG
Sbjct: 242 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRG 301

Query: 303 IIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPE 362
           IIPLENLSIREV+D +KPNCFELYIP+NK Q+IKACKTEADGRVVEGNH VYRISAPT E
Sbjct: 302 IIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQE 361

Query: 363 EKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKR 396
           EK+EWIK I+AA+S DPFYEMLAARKK++S  K+
Sbjct: 362 EKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKK 395


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  689 bits (1778), Expect = 0.0
 Identities = 333/388 (85%), Positives = 359/388 (92%)

Query: 8   VPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVA 67
           VP DL+ EER+EL +IRRRK+EL+ DI+RLK EIAEV  EI+NL S EE K  QRNKQ+A
Sbjct: 12  VPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIA 71

Query: 68  MGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVL 127
           MGRKKFNMDPKKGIQFLIENDLL+++ ED+AQFLYKGEGLNKT IGDYLGERDEFNI+VL
Sbjct: 72  MGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVL 131

Query: 128 HAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCY 187
            AFVELHEF DLNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYC CN GVFQSTDTCY
Sbjct: 132 QAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCY 191

Query: 188 VLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIP 247
           VLSFAIIMLNTSLHN NV+DKPT ERFIAMNRGIN+GGDLPEELLRNLYESIKNEPFKIP
Sbjct: 192 VLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIP 251

Query: 248 EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE 307
           EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE
Sbjct: 252 EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE 311

Query: 308 NLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEW 367
           NLSIREVED +KPNCFELY P +K QVIKACKTEADGRVVEGNH VYRISAP+PEEKEEW
Sbjct: 312 NLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEW 371

Query: 368 IKCIKAAISRDPFYEMLAARKKKVSSTK 395
           +K IKA+ISRDPFY+MLA RK+++++ K
Sbjct: 372 MKSIKASISRDPFYDMLATRKRRIANKK 399


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  686 bits (1771), Expect = 0.0
 Identities = 328/395 (83%), Positives = 365/395 (92%), Gaps = 1/395 (0%)

Query: 3   EDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQR 62
           ED  Y P DLT EER ELENIRRRKQELL +IQRL++E++E  +E+E L + E  K +QR
Sbjct: 2   EDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQR 61

Query: 63  NKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEF 122
           N+++AMGRKKFNMDPKKGIQFL+EN+LL+NT E+IA+FLYKGEGLNKTAIGDYLGER+E 
Sbjct: 62  NRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREEL 121

Query: 123 NIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQS 182
           N+ VLHAFV+LHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC CN GVFQS
Sbjct: 122 NLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQS 181

Query: 183 TDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNE 242
           TDTCYVLSFA+IMLNTSLHNPNV+DKP +ERF+AMNRGIN+GGDLPEELLRNLY+SI+NE
Sbjct: 182 TDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNE 241

Query: 243 PFKIPEDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 301
           PFKIPEDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTDKEPR
Sbjct: 242 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 301

Query: 302 GIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTP 361
           GIIPLENLSIREV+D +KPNCFELYIP+NK Q+IKACKTEADGRVVEGNH VYRISAPT 
Sbjct: 302 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ 361

Query: 362 EEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKR 396
           EEK+EWIK I+AA+S DPFYEMLAARKK++S  K+
Sbjct: 362 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKK 396


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score =  580 bits (1495), Expect = e-166
 Identities = 273/385 (70%), Positives = 330/385 (85%)

Query: 9   PSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAM 68
           P++L++ E +EL+ I+  +++LL DIQ+LKDEIA+V  +I+   S EE +  Q+ K++ +
Sbjct: 8   PAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCI 67

Query: 69  GRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLH 128
           GRKKFNMDP KGIQ+ IE+ LL    +DIA+FLYKGEGLNKTAIG YLGERD  N+QVL 
Sbjct: 68  GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127

Query: 129 AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYV 188
           AFV+ HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYC CN GVFQSTDTCYV
Sbjct: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYV 187

Query: 189 LSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPE 248
           LSF+IIMLNTSLHNPNV+D+P  ERF++MNRGIN+G DLPE+ LRNL++SIK+EPF IPE
Sbjct: 188 LSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247

Query: 249 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLEN 308
           DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLEN
Sbjct: 248 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLEN 307

Query: 309 LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWI 368
           LS+++V+D KKP C ELY P  + Q IKACKT+ DGRVVEG H  YRISA + EE+++WI
Sbjct: 308 LSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWI 367

Query: 369 KCIKAAISRDPFYEMLAARKKKVSS 393
           + I+A+I+R PFY++++ RKKK++S
Sbjct: 368 ESIRASITRVPFYDLVSTRKKKIAS 392


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score =  198 bits (504), Expect = 6e-51
 Identities = 100/211 (47%), Positives = 143/211 (67%), Gaps = 3/211 (1%)

Query: 41  IAEVANEIENLGSTEERKNMQRNKQVA-MGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQ 99
           I   + ++    + E+ + +++ K++   G   FN  PK+GIQ+L E  +L  T EDIAQ
Sbjct: 676 IGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQ 735

Query: 100 FLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQ 159
           FL++ E L+ T +G++LG+ D+FN +V++A+V+ H+F+  + V ALR FL  FRLPGEAQ
Sbjct: 736 FLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795

Query: 160 KIDRMMEAFAQRYCQCNNG--VFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAM 217
           KIDR+ME FA RY +CN G  +F S DT YVL+++IIML T LH+P VK+K T E++I M
Sbjct: 796 KIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM 855

Query: 218 NRGINDGGDLPEELLRNLYESIKNEPFKIPE 248
           NRGIND  DLPEE L  +Y  I  +   + E
Sbjct: 856 NRGINDSKDLPEEYLSAIYNEIAGKKISMKE 886


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score =  194 bits (494), Expect = 9e-50
 Identities = 98/190 (51%), Positives = 133/190 (70%), Gaps = 2/190 (1%)

Query: 61  QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120
           Q+ + +  G + FN  PK+GIQFL E  +L  + EDIAQFL++ E L+ T +GD+LG+  
Sbjct: 642 QQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNG-- 178
            FN +V++A+V+  +F +   V ALR FL  FRLPGEAQKIDR+ME FA RY +CN G  
Sbjct: 702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT 761

Query: 179 VFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYES 238
           +F S DT YVL+++IIML T LH+P VK+K T E++I MNRGIND  DLPEE L ++YE 
Sbjct: 762 LFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 821

Query: 239 IKNEPFKIPE 248
           I+ +   + E
Sbjct: 822 IEGKKIAMKE 831


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score =  161 bits (408), Expect = 8e-40
 Identities = 84/194 (43%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
           R +   +G   FN  P+KG+Q+LIE   + +T   +A FL + +GL++  IG++LG R  
Sbjct: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC CN GV 
Sbjct: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629

Query: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235
             F++ DT ++L+FAII+LNT +++PNVK   K  +E FI   RG++DG D+P E+L  +
Sbjct: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689

Query: 236 YESIKNEPFKIPED 249
           YE I+    K  ED
Sbjct: 690 YERIRKRELKTNED 703


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score =  161 bits (408), Expect = 8e-40
 Identities = 84/194 (43%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
           R +   +G   FN  P+KG+Q+LIE   + +T   +A FL + +GL++  IG++LG R  
Sbjct: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC CN GV 
Sbjct: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643

Query: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235
             F++ DT ++L+FAII+LNT +++PNVK   K  +E FI   RG++DG D+P E+L  +
Sbjct: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703

Query: 236 YESIKNEPFKIPED 249
           YE I+    K  ED
Sbjct: 704 YERIRKRELKTNED 717


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score =  156 bits (395), Expect = 3e-38
 Identities = 82/194 (42%), Positives = 126/194 (64%), Gaps = 6/194 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGE-RD 120
           R +   +G   FN++P KGIQFLI    + +T   +A FL + +GL++  IG++LG  + 
Sbjct: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC CN  V 
Sbjct: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467

Query: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235
             F + DT ++L+FAII+LNT +++PN+K   K  +E FI   RG++DG D+P EL+  +
Sbjct: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527

Query: 236 YESIKNEPFKIPED 249
           YE I+ +  K  ED
Sbjct: 528 YERIQQKELKSNED 541


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  149 bits (376), Expect = 4e-36
 Identities = 79/193 (40%), Positives = 121/193 (62%), Gaps = 7/193 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCE--DIAQFLYKGEGLNKTAIGDYLGER 119
           + K +  G ++FN  PKKGIQFL E  LL    +  ++AQ+L +   L+K  IG+++ +R
Sbjct: 699 KKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDR 758

Query: 120 DEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV 179
              NI +L +FV    F  L L +ALR +L +FRLPGEA  I R++EAF +R+  CN   
Sbjct: 759 K--NIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSP 816

Query: 180 FQSTDTCYVLSFAIIMLNTSLHNPNVKDK---PTVERFIAMNRGINDGGDLPEELLRNLY 236
           F ++D C+ L++A+IMLNT  HN NV+ +    T+E F    +G+N G D  +++L ++Y
Sbjct: 817 FANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMY 876

Query: 237 ESIKNEPFKIPED 249
            +IKNE   +PE+
Sbjct: 877 HAIKNEEIVMPEE 889


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score =  147 bits (372), Expect = 1e-35
 Identities = 76/194 (39%), Positives = 126/194 (64%), Gaps = 6/194 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
           + +   +G   FN  P+KGIQ+LIE   L +T   +A F+ + +GL++  IG++LG R  
Sbjct: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
           +FN  VL   V+  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC CN  + 
Sbjct: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667

Query: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVK--DKPTVERFIAMNRGINDGGDLPEELLRNL 235
             F++ DT ++L+FAII+LNT +++P+VK   K  ++ FI   RG+++G D+P +LL  +
Sbjct: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727

Query: 236 YESIKNEPFKIPED 249
           Y+ I+    +  +D
Sbjct: 728 YQRIQGRELRTNDD 741


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score =  147 bits (372), Expect = 1e-35
 Identities = 76/194 (39%), Positives = 126/194 (64%), Gaps = 6/194 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
           + +   +G   FN  P+KGIQ+LIE   L +T   +A F+ + +GL++  IG++LG R  
Sbjct: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
           +FN  VL   V+  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC CN  + 
Sbjct: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872

Query: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVK--DKPTVERFIAMNRGINDGGDLPEELLRNL 235
             F++ DT ++L+FAII+LNT +++P+VK   K  ++ FI   RG+++G D+P +LL  +
Sbjct: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932

Query: 236 YESIKNEPFKIPED 249
           Y+ I+    +  +D
Sbjct: 933 YQRIQGRELRTNDD 946


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score =  117 bits (292), Expect = 2e-26
 Identities = 61/154 (39%), Positives = 91/154 (59%)

Query: 97  IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156
           +A+ LY+ +G  K  +  +LG+ ++F+  V   +++   FT + L QALR FL    L G
Sbjct: 561 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMG 620

Query: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216
           E Q+ +R++  F+QRY QCN     S D  + L+ A+++LNT LH  N+  + T   FI 
Sbjct: 621 ETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIG 680

Query: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDD 250
              G+NDGGD P ELL+ LY SIKNE  +   D+
Sbjct: 681 NLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDE 714


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score =  113 bits (283), Expect = 3e-25
 Identities = 96/347 (27%), Positives = 160/347 (46%), Gaps = 75/347 (21%)

Query: 97  IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156
           +A+ LY+ +   ++ +  +LG+ +EF+  V   +++  +FT + L Q+LR F  +F L G
Sbjct: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113

Query: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216
           E Q+ +R++  F+ RY  CN     S D  + L+ AI++LNT LH  N+  K T + FIA
Sbjct: 114 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 173

Query: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDG------------------------- 251
             +G+N+G D  ++LL+ LY SIKNE  +   DD                          
Sbjct: 174 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI 233

Query: 252 NDLTHTFF----NPD----REGWLLK-----LGGR-----VKTWKRRWFILTDNCLYY-- 291
              T+ F     +P+    + G+L +     + G+      + WK  + +L    LY   
Sbjct: 234 GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQK 293

Query: 292 FEYTTDK-----EPRGIIPLEN-LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGR 345
            EY  +K     + +  + + + L+ +  +  KKPN F+L             KT AD R
Sbjct: 294 DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKL-------------KT-ADWR 339

Query: 346 VVEGNHTVYRISAPTPEEKEEW---IKCIKAAISRDPFYEMLAARKK 389
           V+            +PEE + W   I C+ A  S  PF   + ++KK
Sbjct: 340 VL-------LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKK 379


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
           isoform a [Homo sapiens]
          Length = 1047

 Score =  113 bits (283), Expect = 3e-25
 Identities = 96/347 (27%), Positives = 160/347 (46%), Gaps = 75/347 (21%)

Query: 97  IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156
           +A+ LY+ +   ++ +  +LG+ +EF+  V   +++  +FT + L Q+LR F  +F L G
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647

Query: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216
           E Q+ +R++  F+ RY  CN     S D  + L+ AI++LNT LH  N+  K T + FIA
Sbjct: 648 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707

Query: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDG------------------------- 251
             +G+N+G D  ++LL+ LY SIKNE  +   DD                          
Sbjct: 708 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI 767

Query: 252 NDLTHTFF----NPD----REGWLLK-----LGGR-----VKTWKRRWFILTDNCLYY-- 291
              T+ F     +P+    + G+L +     + G+      + WK  + +L    LY   
Sbjct: 768 GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQK 827

Query: 292 FEYTTDK-----EPRGIIPLEN-LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGR 345
            EY  +K     + +  + + + L+ +  +  KKPN F+L             KT AD R
Sbjct: 828 DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKL-------------KT-ADWR 873

Query: 346 VVEGNHTVYRISAPTPEEKEEW---IKCIKAAISRDPFYEMLAARKK 389
           V+            +PEE + W   I C+ A  S  PF   + ++KK
Sbjct: 874 VL-------LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKK 913


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score =  112 bits (279), Expect = 8e-25
 Identities = 65/172 (37%), Positives = 99/172 (57%), Gaps = 9/172 (5%)

Query: 88  DLLKNTCEDI-------AQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLN 140
           D L N C+ +       A+ LY  EG  +  +   LG+ +EF+  V   ++   +F+ L 
Sbjct: 301 DPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLT 360

Query: 141 LVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSL 200
           L  ALR FL +F L GE Q+ +R++  F++RYCQCN     S D  + L+ A+++LNT L
Sbjct: 361 LDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDL 420

Query: 201 HNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFK--IPEDD 250
           H  N+  K + ++FIA    +NDG D  ++LL+ LY SIKNE  +  I ED+
Sbjct: 421 HGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score =  111 bits (277), Expect = 1e-24
 Identities = 55/155 (35%), Positives = 94/155 (60%)

Query: 96  DIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLP 155
           ++A  LY+ EG  K+ +  YL + ++F+  V   ++   +F   +L +ALR FL +  L 
Sbjct: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649

Query: 156 GEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFI 215
           GE Q+ +R++  F++R+  CN G+F S D+ + L+ AI++LNT LH  N+    + + FI
Sbjct: 650 GETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFI 709

Query: 216 AMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDD 250
               G+ DGG+ P+ELL+ LY SI++E  +   D+
Sbjct: 710 TNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDE 744


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 53/180 (29%), Positives = 96/180 (53%), Gaps = 11/180 (6%)

Query: 65  QVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNI 124
           Q+  G   FN +P +G+ + +   +L ++ ++IA+F++    LN   +  YL ER +   
Sbjct: 138 QLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRD--- 194

Query: 125 QVLHAFVELHEFTDLNLVQALRQFLWSFRLPGE-AQKIDRMMEAFAQRYCQCNNGVFQ-- 181
            VL   V LH F +  L  ALR+F      P E  + ++ ++  F+ R+C CN  + +  
Sbjct: 195 -VLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMREL 253

Query: 182 --STDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESI 239
             S D  YVL +++I+L+  L +P+VK+K +   FI   R      ++ E+ + +LY++I
Sbjct: 254 GLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 311


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 37/114 (32%), Positives = 55/114 (48%), Gaps = 16/114 (14%)

Query: 265 GWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIRE---VEDSKKPN 321
           GWL K GG VKTW  RWF+L  + LYYF+   + +P G I L    + E    E++    
Sbjct: 24  GWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGKF 83

Query: 322 CFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAI 375
            FE+    ++D+             +  NH  Y + A T  + E+W+K I+  I
Sbjct: 84  LFEVVPGGDRDR-------------MTANHESYLLMASTQNDMEDWVKSIRRVI 124


>gi|50234893 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 33/113 (29%), Positives = 60/113 (53%), Gaps = 18/113 (15%)

Query: 263 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNC 322
           + G+ +K G  +K WKRR+F L +N + YF+   +KEP  +IPL+   + +V++ K+   
Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLK--EVHKVQECKQS-- 249

Query: 323 FELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAI 375
            ++ + DN  +++   +T             + + A +PEE   WIK +  AI
Sbjct: 250 -DIMMRDNLFEIVTTSRT-------------FYVQADSPEEMHSWIKAVSGAI 288


>gi|31377720 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 33/113 (29%), Positives = 60/113 (53%), Gaps = 18/113 (15%)

Query: 263 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNC 322
           + G+ +K G  +K WKRR+F L +N + YF+   +KEP  +IPL+   + +V++ K+   
Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLK--EVHKVQECKQS-- 249

Query: 323 FELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAI 375
            ++ + DN  +++   +T             + + A +PEE   WIK +  AI
Sbjct: 250 -DIMMRDNLFEIVTTSRT-------------FYVQADSPEEMHSWIKAVSGAI 288


>gi|158631203 dual adaptor of phosphotyrosine and
           3-phosphoinositides [Homo sapiens]
          Length = 280

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 38/116 (32%), Positives = 53/116 (45%), Gaps = 23/116 (19%)

Query: 263 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDS-KKPN 321
           +EG+L K GG VKTWK RWF L  N L YF+     EP  I+ L   S  + + S ++ N
Sbjct: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVN 226

Query: 322 CFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISR 377
           CF L  P                         + + A T  E +EWIK ++  +S+
Sbjct: 227 CFCLVFP----------------------FRTFYLCAKTGVEADEWIKILRWKLSQ 260


>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
           sapiens]
          Length = 1048

 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 34/113 (30%), Positives = 53/113 (46%), Gaps = 19/113 (16%)

Query: 263 REGWLLKLGGR-VKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPN 321
           + GWL K     VK W +RWF+L D CL+Y++   ++   G IPL +  +  V+ S    
Sbjct: 62  KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPS---- 117

Query: 322 CFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAA 374
                     D + +    +A+   V      Y  SA +PEE+E WI+ +  A
Sbjct: 118 ----------DNISRKHTFKAEHAGVR----TYFFSAESPEEQEAWIQAMGEA 156


>gi|217416392 pleckstrin homology domain containing, family H (with
           MyTH4 domain) member 2 [Homo sapiens]
          Length = 1493

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 36/113 (31%), Positives = 58/113 (51%), Gaps = 26/113 (23%)

Query: 262 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTD--KEPRGIIPLENLSIREVEDSKK 319
           ++ G+LLK+ G+VK+WKRRWF+L    L Y++  +D  ++P+G I L             
Sbjct: 705 EKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIEL------------S 752

Query: 320 PNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIK 372
            +C  +   DNK  V          ++    HT Y ++A +P   EEWIK ++
Sbjct: 753 ASC-SILRGDNKQTV----------QLTTEKHTYY-LTADSPNILEEWIKVLQ 793



 Score = 32.0 bits (71), Expect = 1.0
 Identities = 17/40 (42%), Positives = 19/40 (47%)

Query: 278 KRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDS 317
           KR W  L    LYYF    DK P G I L    + EV+ S
Sbjct: 827 KRVWCTLIGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRS 866


>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
          Length = 249

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 25/58 (43%), Positives = 36/58 (62%)

Query: 262 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKK 319
           D  G+L K GGR   + RRWF+L  N L+YFE    +EP G+I LE  ++  VE +++
Sbjct: 19  DNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGVIILEGCTVELVEAAEE 76


>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
           sapiens]
          Length = 631

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 20/113 (17%)

Query: 263 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNC 322
           ++G+L K G   + W  RWF L  +CL YF     KE RGIIPL+             +C
Sbjct: 219 KQGYLWKRGHLRRNWAERWFQLQPSCLCYFGSEECKEKRGIIPLD------------AHC 266

Query: 323 FELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAI 375
               +PD   +    C        V+  +  Y +SA    +++EW   I+ AI
Sbjct: 267 CVEVLPDRDGKRCMFC--------VKTANRTYEMSASDTRQRQEWTAAIQMAI 311


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 36/116 (31%), Positives = 60/116 (51%), Gaps = 23/116 (19%)

Query: 263 REGWLLKLGGRVKTWKRRWFIL--TDNCLYYFEYTTDK-EPRGIIPLENLSIREVEDSK- 318
           ++G+LLK G + K WK  +FIL  +D  L YFE      +P+G+I L   S+  V DS  
Sbjct: 477 KKGYLLKKG-KGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLF 535

Query: 319 -KPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKA 373
            +PNCF++ +    ++                 H ++  +  TPE+ E+W+K ++A
Sbjct: 536 GRPNCFQIVVQHFSEE-----------------HYIFYFAGETPEQAEDWMKGLQA 574


>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
          Length = 870

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 36/116 (31%), Positives = 60/116 (51%), Gaps = 23/116 (19%)

Query: 263 REGWLLKLGGRVKTWKRRWFIL--TDNCLYYFEYTTDK-EPRGIIPLENLSIREVEDSK- 318
           ++G+LLK G + K WK  +FIL  +D  L YFE      +P+G+I L   S+  V DS  
Sbjct: 300 KKGYLLKKG-KGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLF 358

Query: 319 -KPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKA 373
            +PNCF++ +    ++                 H ++  +  TPE+ E+W+K ++A
Sbjct: 359 GRPNCFQIVVQHFSEE-----------------HYIFYFAGETPEQAEDWMKGLQA 397


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,245,039
Number of Sequences: 37866
Number of extensions: 696441
Number of successful extensions: 3607
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 145
Number of HSP's that attempted gapping in prelim test: 3222
Number of HSP's gapped (non-prelim): 482
length of query: 397
length of database: 18,247,518
effective HSP length: 104
effective length of query: 293
effective length of database: 14,309,454
effective search space: 4192670022
effective search space used: 4192670022
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.