Search of human proteins with 156151420

Search of human proteins with 156151420

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156151420 hexokinase domain containing 1 [Homo sapiens]
         (917 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156151420 hexokinase domain containing 1 [Homo sapiens]           1821   0.0  
gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]                 1351   0.0  
gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]            1323   0.0  
gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]            1323   0.0  
gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]              1323   0.0  
gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]                1323   0.0  
gi|15553127 hexokinase 2 [Homo sapiens]                              1308   0.0  
gi|194097330 hexokinase 3 [Homo sapiens]                              950   0.0  
gi|4503951 glucokinase isoform 1 [Homo sapiens]                       495   e-140
gi|15967161 glucokinase isoform 3 [Homo sapiens]                      494   e-139
gi|15967159 glucokinase isoform 2 [Homo sapiens]                      493   e-139
gi|164663810 ribosomal modification protein rimK-like family mem...    33   1.2  
gi|65301164 very low density lipoprotein receptor isoform b [Hom...    32   2.1  
gi|65301167 very low density lipoprotein receptor isoform a [Hom...    32   2.1  
gi|30425438 OAF homolog [Homo sapiens]                                 32   3.5  
gi|46367787 poly(A) binding protein, cytoplasmic 1 [Homo sapiens]      31   4.6  
gi|45238849 poly(A) binding protein, cytoplasmic 3 [Homo sapiens]      31   4.6  
gi|11693132 UPF2 regulator of nonsense transcripts homolog [Homo...    31   6.0  
gi|18375676 UPF2 regulator of nonsense transcripts homolog [Homo...    31   6.0  
gi|38201621 eukaryotic translation initiation factor 4 gamma, 1 ...    30   7.9  
gi|38201627 eukaryotic translation initiation factor 4 gamma, 1 ...    30   7.9  
gi|38201625 eukaryotic translation initiation factor 4 gamma, 1 ...    30   7.9  
gi|38201623 eukaryotic translation initiation factor 4 gamma, 1 ...    30   7.9  
gi|38201619 eukaryotic translation initiation factor 4 gamma, 1 ...    30   7.9  

>gi|156151420 hexokinase domain containing 1 [Homo sapiens]
          Length = 917

 Score = 1821 bits (4718), Expect = 0.0
 Identities = 917/917 (100%), Positives = 917/917 (100%)

Query: 1   MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA 60
           MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA
Sbjct: 1   MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA 60

Query: 61  VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR 120
           VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR
Sbjct: 61  VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR 120

Query: 121 GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV 180
           GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV
Sbjct: 121 GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV 180

Query: 181 QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME 240
           QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME
Sbjct: 181 QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME 240

Query: 241 DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL 300
           DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL
Sbjct: 241 DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL 300

Query: 301 YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG 360
           YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG
Sbjct: 301 YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG 360

Query: 361 LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH 420
           LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH
Sbjct: 361 LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH 420

Query: 421 PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT 480
           PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT
Sbjct: 421 PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT 480

Query: 481 REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV 540
           REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV
Sbjct: 481 REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV 540

Query: 541 LLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFT 600
           LLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFT
Sbjct: 541 LLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFT 600

Query: 601 FSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGT 660
           FSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGT
Sbjct: 601 FSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGT 660

Query: 661 MMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDI 720
           MMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDI
Sbjct: 661 MMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDI 720

Query: 721 RTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGI 780
           RTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGI
Sbjct: 721 RTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGI 780

Query: 781 FETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAI 840
           FETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAI
Sbjct: 781 FETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAI 840

Query: 841 VEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGA 900
           VEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGA
Sbjct: 841 VEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGA 900

Query: 901 ALITAVAKRLQQAQKEN 917
           ALITAVAKRLQQAQKEN
Sbjct: 901 ALITAVAKRLQQAQKEN 917


>gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]
          Length = 917

 Score = 1351 bits (3496), Expect = 0.0
 Identities = 651/912 (71%), Positives = 782/912 (85%), Gaps = 1/912 (0%)

Query: 1   MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA 60
           M A  L+A+YF++LK+DQ+KK+D++LY MRLSD+TL+DIM RFR EM+ GL++D NPTA 
Sbjct: 1   MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60

Query: 61  VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR 120
           VKMLPTFVR+IPDGSE G+F++LDLGGS FR+L+VQV  E  ++V MES+ Y TP  I+ 
Sbjct: 61  VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120

Query: 121 GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV 180
           G+G++LF++VA+CL DFM+ + +K KKLP+G TFSFPC+Q+K++E +L++WTK+FKA GV
Sbjct: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180

Query: 181 QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME 240
           +  DVV  L KA+++  D D +I+A+VNDTVGTMMTC YDD +CEVG+IIGTGTNACYME
Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240

Query: 241 DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL 300
           ++ +IDLVEGDEGRMCINTEWGAFGDDG+LEDIRTEFDRE+D GSLNPGKQLFEKM+SG+
Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300

Query: 301 YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG 360
           YLGELVRLIL+KMAK GLLF G  +  L T+GK  T  V+A+EK KEGL N +EIL  LG
Sbjct: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360

Query: 361 LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH 420
           +EPS+ DC++VQHVCTIVSFRSANL AA L AIL RLR+NK   RLRTTVG+DG+LYK H
Sbjct: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 420

Query: 421 PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT 480
           PQY +R HK +R+LVP  DVRFLLSESGS KGAAMVTAVA R+  Q +QI+  LA F LT
Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480

Query: 481 REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV 540
           ++ L++V+ +MRAE+E GL+K++H  A V+MLP++V   PDGTE G FLALDLGGTNFRV
Sbjct: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540

Query: 541 LLVKIRSG-RRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGF 599
           LLVKIRSG +R+V M+NKI+AIP+EIMQGTGEELFDHIV CI+DFLDYMG+KG  +PLGF
Sbjct: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600

Query: 600 TFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVG 659
           TFSFPC+Q S+D G LI WTKGFKATDC G DVV +LR+AIKRR EFDLD+VAVVNDTVG
Sbjct: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660

Query: 660 TMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDD 719
           TMMTC YE+P CE+GLI GTGSN CYME+M+N+EMVEG +G+MCIN EWG FGDNGC+DD
Sbjct: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720

Query: 720 IRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRG 779
           IRT YD  VDE SLN GKQRYEKM SGMYLGEIVR ILID TK+G LFRGQISE L+TRG
Sbjct: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780

Query: 780 IFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAA 839
           IFETKFLSQIESDRLALLQVR ILQQLGL+STC+DSI+VK VCG VSRRAAQLCGAG+AA
Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840

Query: 840 IVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKG 899
           +V+K RE++GL+ L +TVGVDGTLYKLHPHFSRI+ +TVKEL+P+C+V+F+LSEDGSGKG
Sbjct: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900

Query: 900 AALITAVAKRLQ 911
           AALITAV  RL+
Sbjct: 901 AALITAVGVRLR 912



 Score =  498 bits (1282), Expect = e-140
 Identities = 235/450 (52%), Positives = 332/450 (73%)

Query: 17  DQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSE 76
           +Q ++++  L H  L+ D LL++ +R RAEME GL K T+  A VKMLP+FVR  PDG+E
Sbjct: 465 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 524

Query: 77  NGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLAD 136
           NG+FL+LDLGG+ FRVL V++    KR V+M ++ Y  P EI++G G ELF+++  C++D
Sbjct: 525 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 584

Query: 137 FMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRH 196
           F+    +K  ++PLG TFSFPC+QT L+ G+L++WTK FKA      DVV+ L  A++R 
Sbjct: 585 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 644

Query: 197 KDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMC 256
           ++ D+D++A+VNDTVGTMMTCAY++P CEVG+I+GTG+NACYME+M N+++VEGD+G+MC
Sbjct: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 704

Query: 257 INTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKA 316
           IN EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKMISG+YLGE+VR IL+   K 
Sbjct: 705 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 764

Query: 317 GLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCT 376
           G LF G+ S  L T+G  ET+ ++ +E  +  L   R IL  LGL  +  D I V+ VC 
Sbjct: 765 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 824

Query: 377 IVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVP 436
           +VS R+A LC A +AA++ ++REN+ ++RL  TVG+DGTLYK+HP + + +H+ V++L P
Sbjct: 825 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 884

Query: 437 SCDVRFLLSESGSTKGAAMVTAVASRVQAQ 466
            C+V FLLSE GS KGAA++TAV  R++ +
Sbjct: 885 KCNVSFLLSEDGSGKGAALITAVGVRLRTE 914



 Score =  496 bits (1278), Expect = e-140
 Identities = 236/452 (52%), Positives = 333/452 (73%), Gaps = 1/452 (0%)

Query: 466 QRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEK 525
           Q K+ID+ L   +L+ E L+D+  + R E++ GL +  +  ATV+MLPT+V  +PDG+EK
Sbjct: 18  QVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEK 77

Query: 526 GKFLALDLGGTNFRVLLVKIRSGR-RSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADF 584
           G F+ALDLGG++FR+L V++   + ++V M ++++  P  I+ G+G +LFDH+ +C+ DF
Sbjct: 78  GDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDF 137

Query: 585 LDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRN 644
           ++   +K   LP+GFTFSFPC+Q  ID+  LI WTK FKA+  EG DVV +L +AIK+R 
Sbjct: 138 MEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRG 197

Query: 645 EFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCI 704
           ++D +IVAVVNDTVGTMMTCGY+D +CE+GLI GTG+N CYME++R+I++VEG EG+MCI
Sbjct: 198 DYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 257

Query: 705 NTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQG 764
           NTEWG FGD+G ++DIRT +D E+D GSLNPGKQ +EKM SGMYLGE+VR IL+ + K+G
Sbjct: 258 NTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEG 317

Query: 765 LLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGA 824
           LLF G+I+  L TRG F T  +S IE ++  L   + IL +LG++ + +D + V+ VC  
Sbjct: 318 LLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTI 377

Query: 825 VSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPR 884
           VS R+A L  A L AI+ + R+++G   LR TVGVDG+LYK HP +SR   +T++ L P 
Sbjct: 378 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPD 437

Query: 885 CDVTFMLSEDGSGKGAALITAVAKRLQQAQKE 916
            DV F+LSE GSGKGAA++TAVA RL +  ++
Sbjct: 438 SDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQ 469


>gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
          Length = 921

 Score = 1323 bits (3425), Expect = 0.0
 Identities = 639/892 (71%), Positives = 765/892 (85%), Gaps = 1/892 (0%)

Query: 21  KVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEF 80
           ++D++LY MRLSD+TL+DIM RFR EM+ GL++D NPTA VKMLPTFVR+IPDGSE G+F
Sbjct: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84

Query: 81  LSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMKT 140
           ++LDLGGS FR+L+VQV  E  ++V MES+ Y TP  I+ G+G++LF++VA+CL DFM+ 
Sbjct: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144

Query: 141 KDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDMD 200
           + +K KKLP+G TFSFPC+Q+K++E +L++WTK+FKA GV+  DVV  L KA+++  D D
Sbjct: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204

Query: 201 VDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTE 260
            +I+A+VNDTVGTMMTC YDD +CEVG+IIGTGTNACYME++ +IDLVEGDEGRMCINTE
Sbjct: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264

Query: 261 WGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLLF 320
           WGAFGDDG+LEDIRTEFDRE+D GSLNPGKQLFEKM+SG+YLGELVRLIL+KMAK GLLF
Sbjct: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324

Query: 321 GGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVSF 380
            G  +  L T+GK  T  V+A+EK KEGL N +EIL  LG+EPS+ DC++VQHVCTIVSF
Sbjct: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384

Query: 381 RSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCDV 440
           RSANL AA L AIL RLR+NK   RLRTTVG+DG+LYK HPQY +R HK +R+LVP  DV
Sbjct: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444

Query: 441 RFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLK 500
           RFLLSESGS KGAAMVTAVA R+  Q +QI+  LA F LT++ L++V+ +MRAE+E GL+
Sbjct: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 504

Query: 501 KKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSG-RRSVRMYNKIF 559
           K++H  A V+MLP++V   PDGTE G FLALDLGGTNFRVLLVKIRSG +R+V M+NKI+
Sbjct: 505 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 564

Query: 560 AIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWT 619
           AIP+EIMQGTGEELFDHIV CI+DFLDYMG+KG  +PLGFTFSFPC+Q S+D G LI WT
Sbjct: 565 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 624

Query: 620 KGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGT 679
           KGFKATDC G DVV +LR+AIKRR EFDLD+VAVVNDTVGTMMTC YE+P CE+GLI GT
Sbjct: 625 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 684

Query: 680 GSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQR 739
           GSN CYME+M+N+EMVEG +G+MCIN EWG FGDNGC+DDIRT YD  VDE SLN GKQR
Sbjct: 685 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 744

Query: 740 YEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQV 799
           YEKM SGMYLGEIVR ILID TK+G LFRGQISE L+TRGIFETKFLSQIESDRLALLQV
Sbjct: 745 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 804

Query: 800 RRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGV 859
           R ILQQLGL+STC+DSI+VK VCG VSRRAAQLCGAG+AA+V+K RE++GL+ L +TVGV
Sbjct: 805 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 864

Query: 860 DGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQ 911
           DGTLYKLHPHFSRI+ +TVKEL+P+C+V+F+LSEDGSGKGAALITAV  RL+
Sbjct: 865 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 916



 Score =  498 bits (1282), Expect = e-140
 Identities = 235/450 (52%), Positives = 332/450 (73%)

Query: 17  DQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSE 76
           +Q ++++  L H  L+ D LL++ +R RAEME GL K T+  A VKMLP+FVR  PDG+E
Sbjct: 469 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 528

Query: 77  NGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLAD 136
           NG+FL+LDLGG+ FRVL V++    KR V+M ++ Y  P EI++G G ELF+++  C++D
Sbjct: 529 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 588

Query: 137 FMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRH 196
           F+    +K  ++PLG TFSFPC+QT L+ G+L++WTK FKA      DVV+ L  A++R 
Sbjct: 589 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 648

Query: 197 KDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMC 256
           ++ D+D++A+VNDTVGTMMTCAY++P CEVG+I+GTG+NACYME+M N+++VEGD+G+MC
Sbjct: 649 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 708

Query: 257 INTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKA 316
           IN EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKMISG+YLGE+VR IL+   K 
Sbjct: 709 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 768

Query: 317 GLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCT 376
           G LF G+ S  L T+G  ET+ ++ +E  +  L   R IL  LGL  +  D I V+ VC 
Sbjct: 769 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 828

Query: 377 IVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVP 436
           +VS R+A LC A +AA++ ++REN+ ++RL  TVG+DGTLYK+HP + + +H+ V++L P
Sbjct: 829 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 888

Query: 437 SCDVRFLLSESGSTKGAAMVTAVASRVQAQ 466
            C+V FLLSE GS KGAA++TAV  R++ +
Sbjct: 889 KCNVSFLLSEDGSGKGAALITAVGVRLRTE 918



 Score =  494 bits (1272), Expect = e-139
 Identities = 234/449 (52%), Positives = 331/449 (73%), Gaps = 1/449 (0%)

Query: 469 QIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKF 528
           +ID+ L   +L+ E L+D+  + R E++ GL +  +  ATV+MLPT+V  +PDG+EKG F
Sbjct: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84

Query: 529 LALDLGGTNFRVLLVKIRSGR-RSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDY 587
           +ALDLGG++FR+L V++   + ++V M ++++  P  I+ G+G +LFDH+ +C+ DF++ 
Sbjct: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144

Query: 588 MGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFD 647
             +K   LP+GFTFSFPC+Q  ID+  LI WTK FKA+  EG DVV +L +AIK+R ++D
Sbjct: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204

Query: 648 LDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTE 707
            +IVAVVNDTVGTMMTCGY+D +CE+GLI GTG+N CYME++R+I++VEG EG+MCINTE
Sbjct: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264

Query: 708 WGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLF 767
           WG FGD+G ++DIRT +D E+D GSLNPGKQ +EKM SGMYLGE+VR IL+ + K+GLLF
Sbjct: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324

Query: 768 RGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSR 827
            G+I+  L TRG F T  +S IE ++  L   + IL +LG++ + +D + V+ VC  VS 
Sbjct: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384

Query: 828 RAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDV 887
           R+A L  A L AI+ + R+++G   LR TVGVDG+LYK HP +SR   +T++ L P  DV
Sbjct: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444

Query: 888 TFMLSEDGSGKGAALITAVAKRLQQAQKE 916
            F+LSE GSGKGAA++TAVA RL +  ++
Sbjct: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQ 473


>gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
          Length = 921

 Score = 1323 bits (3425), Expect = 0.0
 Identities = 639/892 (71%), Positives = 765/892 (85%), Gaps = 1/892 (0%)

Query: 21  KVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEF 80
           ++D++LY MRLSD+TL+DIM RFR EM+ GL++D NPTA VKMLPTFVR+IPDGSE G+F
Sbjct: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84

Query: 81  LSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMKT 140
           ++LDLGGS FR+L+VQV  E  ++V MES+ Y TP  I+ G+G++LF++VA+CL DFM+ 
Sbjct: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144

Query: 141 KDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDMD 200
           + +K KKLP+G TFSFPC+Q+K++E +L++WTK+FKA GV+  DVV  L KA+++  D D
Sbjct: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204

Query: 201 VDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTE 260
            +I+A+VNDTVGTMMTC YDD +CEVG+IIGTGTNACYME++ +IDLVEGDEGRMCINTE
Sbjct: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264

Query: 261 WGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLLF 320
           WGAFGDDG+LEDIRTEFDRE+D GSLNPGKQLFEKM+SG+YLGELVRLIL+KMAK GLLF
Sbjct: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324

Query: 321 GGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVSF 380
            G  +  L T+GK  T  V+A+EK KEGL N +EIL  LG+EPS+ DC++VQHVCTIVSF
Sbjct: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384

Query: 381 RSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCDV 440
           RSANL AA L AIL RLR+NK   RLRTTVG+DG+LYK HPQY +R HK +R+LVP  DV
Sbjct: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444

Query: 441 RFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLK 500
           RFLLSESGS KGAAMVTAVA R+  Q +QI+  LA F LT++ L++V+ +MRAE+E GL+
Sbjct: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 504

Query: 501 KKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSG-RRSVRMYNKIF 559
           K++H  A V+MLP++V   PDGTE G FLALDLGGTNFRVLLVKIRSG +R+V M+NKI+
Sbjct: 505 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 564

Query: 560 AIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWT 619
           AIP+EIMQGTGEELFDHIV CI+DFLDYMG+KG  +PLGFTFSFPC+Q S+D G LI WT
Sbjct: 565 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 624

Query: 620 KGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGT 679
           KGFKATDC G DVV +LR+AIKRR EFDLD+VAVVNDTVGTMMTC YE+P CE+GLI GT
Sbjct: 625 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 684

Query: 680 GSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQR 739
           GSN CYME+M+N+EMVEG +G+MCIN EWG FGDNGC+DDIRT YD  VDE SLN GKQR
Sbjct: 685 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 744

Query: 740 YEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQV 799
           YEKM SGMYLGEIVR ILID TK+G LFRGQISE L+TRGIFETKFLSQIESDRLALLQV
Sbjct: 745 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 804

Query: 800 RRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGV 859
           R ILQQLGL+STC+DSI+VK VCG VSRRAAQLCGAG+AA+V+K RE++GL+ L +TVGV
Sbjct: 805 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 864

Query: 860 DGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQ 911
           DGTLYKLHPHFSRI+ +TVKEL+P+C+V+F+LSEDGSGKGAALITAV  RL+
Sbjct: 865 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 916



 Score =  498 bits (1282), Expect = e-140
 Identities = 235/450 (52%), Positives = 332/450 (73%)

Query: 17  DQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSE 76
           +Q ++++  L H  L+ D LL++ +R RAEME GL K T+  A VKMLP+FVR  PDG+E
Sbjct: 469 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 528

Query: 77  NGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLAD 136
           NG+FL+LDLGG+ FRVL V++    KR V+M ++ Y  P EI++G G ELF+++  C++D
Sbjct: 529 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 588

Query: 137 FMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRH 196
           F+    +K  ++PLG TFSFPC+QT L+ G+L++WTK FKA      DVV+ L  A++R 
Sbjct: 589 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 648

Query: 197 KDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMC 256
           ++ D+D++A+VNDTVGTMMTCAY++P CEVG+I+GTG+NACYME+M N+++VEGD+G+MC
Sbjct: 649 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 708

Query: 257 INTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKA 316
           IN EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKMISG+YLGE+VR IL+   K 
Sbjct: 709 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 768

Query: 317 GLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCT 376
           G LF G+ S  L T+G  ET+ ++ +E  +  L   R IL  LGL  +  D I V+ VC 
Sbjct: 769 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 828

Query: 377 IVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVP 436
           +VS R+A LC A +AA++ ++REN+ ++RL  TVG+DGTLYK+HP + + +H+ V++L P
Sbjct: 829 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 888

Query: 437 SCDVRFLLSESGSTKGAAMVTAVASRVQAQ 466
            C+V FLLSE GS KGAA++TAV  R++ +
Sbjct: 889 KCNVSFLLSEDGSGKGAALITAVGVRLRTE 918



 Score =  494 bits (1272), Expect = e-139
 Identities = 234/449 (52%), Positives = 331/449 (73%), Gaps = 1/449 (0%)

Query: 469 QIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKF 528
           +ID+ L   +L+ E L+D+  + R E++ GL +  +  ATV+MLPT+V  +PDG+EKG F
Sbjct: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84

Query: 529 LALDLGGTNFRVLLVKIRSGR-RSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDY 587
           +ALDLGG++FR+L V++   + ++V M ++++  P  I+ G+G +LFDH+ +C+ DF++ 
Sbjct: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144

Query: 588 MGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFD 647
             +K   LP+GFTFSFPC+Q  ID+  LI WTK FKA+  EG DVV +L +AIK+R ++D
Sbjct: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204

Query: 648 LDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTE 707
            +IVAVVNDTVGTMMTCGY+D +CE+GLI GTG+N CYME++R+I++VEG EG+MCINTE
Sbjct: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264

Query: 708 WGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLF 767
           WG FGD+G ++DIRT +D E+D GSLNPGKQ +EKM SGMYLGE+VR IL+ + K+GLLF
Sbjct: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324

Query: 768 RGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSR 827
            G+I+  L TRG F T  +S IE ++  L   + IL +LG++ + +D + V+ VC  VS 
Sbjct: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384

Query: 828 RAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDV 887
           R+A L  A L AI+ + R+++G   LR TVGVDG+LYK HP +SR   +T++ L P  DV
Sbjct: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444

Query: 888 TFMLSEDGSGKGAALITAVAKRLQQAQKE 916
            F+LSE GSGKGAA++TAVA RL +  ++
Sbjct: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQ 473


>gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]
          Length = 905

 Score = 1323 bits (3424), Expect = 0.0
 Identities = 639/891 (71%), Positives = 764/891 (85%), Gaps = 1/891 (0%)

Query: 22  VDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEFL 81
           +D++LY MRLSD+TL+DIM RFR EM+ GL++D NPTA VKMLPTFVR+IPDGSE G+F+
Sbjct: 10  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 69

Query: 82  SLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMKTK 141
           +LDLGGS FR+L+VQV  E  ++V MES+ Y TP  I+ G+G++LF++VA+CL DFM+ +
Sbjct: 70  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 129

Query: 142 DLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDMDV 201
            +K KKLP+G TFSFPC+Q+K++E +L++WTK+FKA GV+  DVV  L KA+++  D D 
Sbjct: 130 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 189

Query: 202 DILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEW 261
           +I+A+VNDTVGTMMTC YDD +CEVG+IIGTGTNACYME++ +IDLVEGDEGRMCINTEW
Sbjct: 190 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 249

Query: 262 GAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLLFG 321
           GAFGDDG+LEDIRTEFDRE+D GSLNPGKQLFEKM+SG+YLGELVRLIL+KMAK GLLF 
Sbjct: 250 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 309

Query: 322 GEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVSFR 381
           G  +  L T+GK  T  V+A+EK KEGL N +EIL  LG+EPS+ DC++VQHVCTIVSFR
Sbjct: 310 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 369

Query: 382 SANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCDVR 441
           SANL AA L AIL RLR+NK   RLRTTVG+DG+LYK HPQY +R HK +R+LVP  DVR
Sbjct: 370 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 429

Query: 442 FLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKK 501
           FLLSESGS KGAAMVTAVA R+  Q +QI+  LA F LT++ L++V+ +MRAE+E GL+K
Sbjct: 430 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 489

Query: 502 KSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSG-RRSVRMYNKIFA 560
           ++H  A V+MLP++V   PDGTE G FLALDLGGTNFRVLLVKIRSG +R+V M+NKI+A
Sbjct: 490 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 549

Query: 561 IPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTK 620
           IP+EIMQGTGEELFDHIV CI+DFLDYMG+KG  +PLGFTFSFPC+Q S+D G LI WTK
Sbjct: 550 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 609

Query: 621 GFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTG 680
           GFKATDC G DVV +LR+AIKRR EFDLD+VAVVNDTVGTMMTC YE+P CE+GLI GTG
Sbjct: 610 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 669

Query: 681 SNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRY 740
           SN CYME+M+N+EMVEG +G+MCIN EWG FGDNGC+DDIRT YD  VDE SLN GKQRY
Sbjct: 670 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 729

Query: 741 EKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVR 800
           EKM SGMYLGEIVR ILID TK+G LFRGQISE L+TRGIFETKFLSQIESDRLALLQVR
Sbjct: 730 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 789

Query: 801 RILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVD 860
            ILQQLGL+STC+DSI+VK VCG VSRRAAQLCGAG+AA+V+K RE++GL+ L +TVGVD
Sbjct: 790 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 849

Query: 861 GTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQ 911
           GTLYKLHPHFSRI+ +TVKEL+P+C+V+F+LSEDGSGKGAALITAV  RL+
Sbjct: 850 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 900



 Score =  498 bits (1282), Expect = e-140
 Identities = 235/450 (52%), Positives = 332/450 (73%)

Query: 17  DQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSE 76
           +Q ++++  L H  L+ D LL++ +R RAEME GL K T+  A VKMLP+FVR  PDG+E
Sbjct: 453 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 512

Query: 77  NGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLAD 136
           NG+FL+LDLGG+ FRVL V++    KR V+M ++ Y  P EI++G G ELF+++  C++D
Sbjct: 513 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 572

Query: 137 FMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRH 196
           F+    +K  ++PLG TFSFPC+QT L+ G+L++WTK FKA      DVV+ L  A++R 
Sbjct: 573 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 632

Query: 197 KDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMC 256
           ++ D+D++A+VNDTVGTMMTCAY++P CEVG+I+GTG+NACYME+M N+++VEGD+G+MC
Sbjct: 633 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 692

Query: 257 INTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKA 316
           IN EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKMISG+YLGE+VR IL+   K 
Sbjct: 693 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 752

Query: 317 GLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCT 376
           G LF G+ S  L T+G  ET+ ++ +E  +  L   R IL  LGL  +  D I V+ VC 
Sbjct: 753 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 812

Query: 377 IVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVP 436
           +VS R+A LC A +AA++ ++REN+ ++RL  TVG+DGTLYK+HP + + +H+ V++L P
Sbjct: 813 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 872

Query: 437 SCDVRFLLSESGSTKGAAMVTAVASRVQAQ 466
            C+V FLLSE GS KGAA++TAV  R++ +
Sbjct: 873 KCNVSFLLSEDGSGKGAALITAVGVRLRTE 902



 Score =  493 bits (1270), Expect = e-139
 Identities = 234/448 (52%), Positives = 330/448 (73%), Gaps = 1/448 (0%)

Query: 470 IDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFL 529
           ID+ L   +L+ E L+D+  + R E++ GL +  +  ATV+MLPT+V  +PDG+EKG F+
Sbjct: 10  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 69

Query: 530 ALDLGGTNFRVLLVKIRSGR-RSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYM 588
           ALDLGG++FR+L V++   + ++V M ++++  P  I+ G+G +LFDH+ +C+ DF++  
Sbjct: 70  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 129

Query: 589 GLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDL 648
            +K   LP+GFTFSFPC+Q  ID+  LI WTK FKA+  EG DVV +L +AIK+R ++D 
Sbjct: 130 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 189

Query: 649 DIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEW 708
           +IVAVVNDTVGTMMTCGY+D +CE+GLI GTG+N CYME++R+I++VEG EG+MCINTEW
Sbjct: 190 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 249

Query: 709 GGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFR 768
           G FGD+G ++DIRT +D E+D GSLNPGKQ +EKM SGMYLGE+VR IL+ + K+GLLF 
Sbjct: 250 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 309

Query: 769 GQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRR 828
           G+I+  L TRG F T  +S IE ++  L   + IL +LG++ + +D + V+ VC  VS R
Sbjct: 310 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 369

Query: 829 AAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVT 888
           +A L  A L AI+ + R+++G   LR TVGVDG+LYK HP +SR   +T++ L P  DV 
Sbjct: 370 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 429

Query: 889 FMLSEDGSGKGAALITAVAKRLQQAQKE 916
           F+LSE GSGKGAA++TAVA RL +  ++
Sbjct: 430 FLLSESGSGKGAAMVTAVAYRLAEQHRQ 457


>gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]
          Length = 916

 Score = 1323 bits (3424), Expect = 0.0
 Identities = 639/891 (71%), Positives = 764/891 (85%), Gaps = 1/891 (0%)

Query: 22  VDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEFL 81
           +D++LY MRLSD+TL+DIM RFR EM+ GL++D NPTA VKMLPTFVR+IPDGSE G+F+
Sbjct: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80

Query: 82  SLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMKTK 141
           +LDLGGS FR+L+VQV  E  ++V MES+ Y TP  I+ G+G++LF++VA+CL DFM+ +
Sbjct: 81  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140

Query: 142 DLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDMDV 201
            +K KKLP+G TFSFPC+Q+K++E +L++WTK+FKA GV+  DVV  L KA+++  D D 
Sbjct: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200

Query: 202 DILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEW 261
           +I+A+VNDTVGTMMTC YDD +CEVG+IIGTGTNACYME++ +IDLVEGDEGRMCINTEW
Sbjct: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260

Query: 262 GAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLLFG 321
           GAFGDDG+LEDIRTEFDRE+D GSLNPGKQLFEKM+SG+YLGELVRLIL+KMAK GLLF 
Sbjct: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320

Query: 322 GEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVSFR 381
           G  +  L T+GK  T  V+A+EK KEGL N +EIL  LG+EPS+ DC++VQHVCTIVSFR
Sbjct: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380

Query: 382 SANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCDVR 441
           SANL AA L AIL RLR+NK   RLRTTVG+DG+LYK HPQY +R HK +R+LVP  DVR
Sbjct: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440

Query: 442 FLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKK 501
           FLLSESGS KGAAMVTAVA R+  Q +QI+  LA F LT++ L++V+ +MRAE+E GL+K
Sbjct: 441 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 500

Query: 502 KSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSG-RRSVRMYNKIFA 560
           ++H  A V+MLP++V   PDGTE G FLALDLGGTNFRVLLVKIRSG +R+V M+NKI+A
Sbjct: 501 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 560

Query: 561 IPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTK 620
           IP+EIMQGTGEELFDHIV CI+DFLDYMG+KG  +PLGFTFSFPC+Q S+D G LI WTK
Sbjct: 561 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 620

Query: 621 GFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTG 680
           GFKATDC G DVV +LR+AIKRR EFDLD+VAVVNDTVGTMMTC YE+P CE+GLI GTG
Sbjct: 621 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 680

Query: 681 SNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRY 740
           SN CYME+M+N+EMVEG +G+MCIN EWG FGDNGC+DDIRT YD  VDE SLN GKQRY
Sbjct: 681 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 740

Query: 741 EKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVR 800
           EKM SGMYLGEIVR ILID TK+G LFRGQISE L+TRGIFETKFLSQIESDRLALLQVR
Sbjct: 741 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 800

Query: 801 RILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVD 860
            ILQQLGL+STC+DSI+VK VCG VSRRAAQLCGAG+AA+V+K RE++GL+ L +TVGVD
Sbjct: 801 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 860

Query: 861 GTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQ 911
           GTLYKLHPHFSRI+ +TVKEL+P+C+V+F+LSEDGSGKGAALITAV  RL+
Sbjct: 861 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 911



 Score =  498 bits (1282), Expect = e-140
 Identities = 235/450 (52%), Positives = 332/450 (73%)

Query: 17  DQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSE 76
           +Q ++++  L H  L+ D LL++ +R RAEME GL K T+  A VKMLP+FVR  PDG+E
Sbjct: 464 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 523

Query: 77  NGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLAD 136
           NG+FL+LDLGG+ FRVL V++    KR V+M ++ Y  P EI++G G ELF+++  C++D
Sbjct: 524 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 583

Query: 137 FMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRH 196
           F+    +K  ++PLG TFSFPC+QT L+ G+L++WTK FKA      DVV+ L  A++R 
Sbjct: 584 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 643

Query: 197 KDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMC 256
           ++ D+D++A+VNDTVGTMMTCAY++P CEVG+I+GTG+NACYME+M N+++VEGD+G+MC
Sbjct: 644 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 703

Query: 257 INTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKA 316
           IN EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKMISG+YLGE+VR IL+   K 
Sbjct: 704 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 763

Query: 317 GLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCT 376
           G LF G+ S  L T+G  ET+ ++ +E  +  L   R IL  LGL  +  D I V+ VC 
Sbjct: 764 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 823

Query: 377 IVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVP 436
           +VS R+A LC A +AA++ ++REN+ ++RL  TVG+DGTLYK+HP + + +H+ V++L P
Sbjct: 824 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 883

Query: 437 SCDVRFLLSESGSTKGAAMVTAVASRVQAQ 466
            C+V FLLSE GS KGAA++TAV  R++ +
Sbjct: 884 KCNVSFLLSEDGSGKGAALITAVGVRLRTE 913



 Score =  493 bits (1270), Expect = e-139
 Identities = 234/448 (52%), Positives = 330/448 (73%), Gaps = 1/448 (0%)

Query: 470 IDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFL 529
           ID+ L   +L+ E L+D+  + R E++ GL +  +  ATV+MLPT+V  +PDG+EKG F+
Sbjct: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80

Query: 530 ALDLGGTNFRVLLVKIRSGR-RSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYM 588
           ALDLGG++FR+L V++   + ++V M ++++  P  I+ G+G +LFDH+ +C+ DF++  
Sbjct: 81  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140

Query: 589 GLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDL 648
            +K   LP+GFTFSFPC+Q  ID+  LI WTK FKA+  EG DVV +L +AIK+R ++D 
Sbjct: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200

Query: 649 DIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEW 708
           +IVAVVNDTVGTMMTCGY+D +CE+GLI GTG+N CYME++R+I++VEG EG+MCINTEW
Sbjct: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260

Query: 709 GGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFR 768
           G FGD+G ++DIRT +D E+D GSLNPGKQ +EKM SGMYLGE+VR IL+ + K+GLLF 
Sbjct: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320

Query: 769 GQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRR 828
           G+I+  L TRG F T  +S IE ++  L   + IL +LG++ + +D + V+ VC  VS R
Sbjct: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380

Query: 829 AAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVT 888
           +A L  A L AI+ + R+++G   LR TVGVDG+LYK HP +SR   +T++ L P  DV 
Sbjct: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440

Query: 889 FMLSEDGSGKGAALITAVAKRLQQAQKE 916
           F+LSE GSGKGAA++TAVA RL +  ++
Sbjct: 441 FLLSESGSGKGAAMVTAVAYRLAEQHRQ 468


>gi|15553127 hexokinase 2 [Homo sapiens]
          Length = 917

 Score = 1308 bits (3385), Expect = 0.0
 Identities = 621/914 (67%), Positives = 775/914 (84%), Gaps = 1/914 (0%)

Query: 1   MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA 60
           M A HL+A++F++L  DQ++KVD++LYHMRLSD+TLL+I +RFR EMEKGL   T+PTAA
Sbjct: 1   MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA 60

Query: 61  VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR 120
           VKMLPTFVR+ PDG+E+GEFL+LDLGG+ FRVL V+V + G + V+ME+Q Y  P +I+R
Sbjct: 61  VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR 120

Query: 121 GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV 180
           G+GT+LF+++A+CLA+FM    +K KKLPLG TFSFPC QTKL+E  L+SWTK FK+ GV
Sbjct: 121 GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV 180

Query: 181 QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME 240
           +  DVV+ + KA++R  D D+DI+A+VNDTVGTMMTC YDD  CE+G+I+GTG+NACYME
Sbjct: 181 EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME 240

Query: 241 DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL 300
           +M +ID+VEGDEGRMCIN EWGAFGDDG+L DIRTEFD+E+D+GSLNPGKQLFEKMISG+
Sbjct: 241 EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM 300

Query: 301 YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG 360
           Y+GELVRLIL+KMAK  LLFGG+ S  L   G+ ET+ ++ +E  K+G+   RE+L+ LG
Sbjct: 301 YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG 360

Query: 361 LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH 420
           L+P++ DC+A   +C IVS RSA+LCAA LAA+L R++ENK  ERLR+T+G+DG++YK H
Sbjct: 361 LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH 420

Query: 421 PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT 480
           P + KRLHK VR+LVP CDVRFL SE GS KGAAMVTAVA R+  Q +   + L   QL+
Sbjct: 421 PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS 480

Query: 481 REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV 540
            +QL++V+ +M+ E+E GL K++H  A V+MLPTYVC  PDGTEKG FLALDLGGTNFRV
Sbjct: 481 HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV 540

Query: 541 LLVKIRSGR-RSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGF 599
           LLV++R+G+   V M+NKI+AIP E+M GTG+ELFDHIVQCIADFL+YMG+KG SLPLGF
Sbjct: 541 LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF 600

Query: 600 TFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVG 659
           TFSFPC+Q S+D+  L+ WTKGFKA+ CEGEDVV +L+EAI RR EFDLD+VAVVNDTVG
Sbjct: 601 TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG 660

Query: 660 TMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDD 719
           TMMTCG+EDP+CE+GLI GTGSN CYME+MRN+E+VEG EG+MC+N EWG FGDNGC+DD
Sbjct: 661 TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720

Query: 720 IRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRG 779
            RT +D  VDE SLNPGKQR+EKM SGMYLGEIVR ILID TK+GLLFRG+ISERL+TRG
Sbjct: 721 FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780

Query: 780 IFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAA 839
           IFETKFLSQIESD LALLQVR ILQ LGL+STC+DSI+VKEVC  V+RRAAQLCGAG+AA
Sbjct: 781 IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA 840

Query: 840 IVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKG 899
           +V++ RE++GL+ L++TVGVDGTLYKLHPHF++++ ETVK+LAP+CDV+F+ SEDGSGKG
Sbjct: 841 VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG 900

Query: 900 AALITAVAKRLQQA 913
           AALITAVA R+++A
Sbjct: 901 AALITAVACRIREA 914


>gi|194097330 hexokinase 3 [Homo sapiens]
          Length = 923

 Score =  950 bits (2456), Expect = 0.0
 Identities = 483/898 (53%), Positives = 633/898 (70%), Gaps = 8/898 (0%)

Query: 17  DQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSE 76
           D  + V   L   +++   L  I       ME+ L    +P  AV+MLPT+V + P G+E
Sbjct: 28  DSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTE 87

Query: 77  NGEFLSLDLG--GSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCL 134
            G+F+ L+LG  G+  RVL V +       V+  SQ +  P E++ G G +LF++ A CL
Sbjct: 88  QGDFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCL 147

Query: 135 ADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMR 194
           ++F+  + +  + L LG +FSFPC QT L+   L+SWTK F+  GV+  DVV  L  A+R
Sbjct: 148 SEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIR 207

Query: 195 RHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGR 254
           R    ++D++A+VNDTVGTMM C      CEVG+++ TGTNACYME+  ++ +++ D GR
Sbjct: 208 RQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGR 267

Query: 255 MCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMA 314
           +C++ EWG+F DDGAL  + T FD  LD  SLNPG Q FEKMI GLYLGELVRL+L  +A
Sbjct: 268 VCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLA 327

Query: 315 KAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHV 374
           + G+LFGG  S AL ++G I   HVA ME    G A    IL DLGL P  +D   VQHV
Sbjct: 328 RCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHV 387

Query: 375 CTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKL 434
           C  V  R+A LCAAALAA+L+ L+ +++ + L+  V   G + + HP++   L   V  L
Sbjct: 388 CAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLL 447

Query: 435 VPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAE 494
            P CDV  + S  G  +G AMVTAVA+R+ A R+ ++  LA F+L  +QL  VQA+MR  
Sbjct: 448 APECDVSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKA 507

Query: 495 LEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSGRRSVRM 554
           +  GL+ ++  L   RMLPT+V   PDG+E+G FLALDLGGTNFRVLLV++ +G   V++
Sbjct: 508 MAKGLRGEASSL---RMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG---VQI 561

Query: 555 YNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGT 614
            ++I++IP  + QG+G++LFDHIV CI DF    GL G SLPLGFTFSFPCRQ+ +D+G 
Sbjct: 562 TSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGI 621

Query: 615 LIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIG 674
           L+ WTKGFKA+DCEG+DVV +LREAI RR   +L++VA+VNDTVGTMM+CGYEDP CEIG
Sbjct: 622 LLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIG 681

Query: 675 LIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLN 734
           LI GTG+N CYME++RN+  V G  G+MCIN EWG FGD+G +  + TR+D  VD+ S+N
Sbjct: 682 LIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASIN 741

Query: 735 PGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRL 794
           PGKQR+EKM SGMYLGEIVR IL+ LT  G+LFRGQ  +RL+TR IF+TKFLS+IESD L
Sbjct: 742 PGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSL 801

Query: 795 ALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLR 854
           AL QVR IL+ LGL  T +D+++V EVC AVS+RAAQLCGAG+AA+VEK RE++GLE L 
Sbjct: 802 ALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELA 861

Query: 855 ITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQQ 912
           ++VGVDGTLYKLHP FS ++  TV+ELAPRC VTF+ SEDGSGKGAAL+TAVA RL Q
Sbjct: 862 VSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRLAQ 919


>gi|4503951 glucokinase isoform 1 [Homo sapiens]
          Length = 465

 Score =  495 bits (1274), Expect = e-140
 Identities = 236/446 (52%), Positives = 327/446 (73%), Gaps = 3/446 (0%)

Query: 465 AQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTE 524
           A++++++++LA FQL  E L  V  +M+ E++ GL+ ++H  A+V+MLPTYV   P+G+E
Sbjct: 11  AKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE 70

Query: 525 KGKFLALDLGGTNFRVLLVKIRSGRR---SVRMYNKIFAIPLEIMQGTGEELFDHIVQCI 581
            G FL+LDLGGTNFRV+LVK+  G     SV+  +++++IP + M GT E LFD+I +CI
Sbjct: 71  VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECI 130

Query: 582 ADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIK 641
           +DFLD   +K   LPLGFTFSFP R   IDKG L+ WTKGFKA+  EG +VV +LR+AIK
Sbjct: 131 SDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIK 190

Query: 642 RRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGK 701
           RR +F++D+VA+VNDTV TM++C YED  CE+G+I GTG N CYME+M+N+E+VEG EG+
Sbjct: 191 RRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR 250

Query: 702 MCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLT 761
           MC+NTEWG FGD+G +D+    YD  VDE S NPG+Q YEK+  G Y+GE+VR +L+ L 
Sbjct: 251 MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLV 310

Query: 762 KQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEV 821
            + LLF G+ SE+LRTRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  +V+  
Sbjct: 311 DENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRA 370

Query: 822 CGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKEL 881
           C +VS RAA +C AGLA ++ + RE +  + +RITVGVDG++YKLHP F      +V+ L
Sbjct: 371 CESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL 430

Query: 882 APRCDVTFMLSEDGSGKGAALITAVA 907
            P C++TF+ SE+GSG+GAAL++AVA
Sbjct: 431 TPSCEITFIESEEGSGRGAALVSAVA 456



 Score =  472 bits (1214), Expect = e-133
 Identities = 222/453 (49%), Positives = 323/453 (71%), Gaps = 2/453 (0%)

Query: 12  SKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAI 71
           ++++  + +KV++ L   +L ++ L  +MRR + EM++GL  +T+  A+VKMLPT+VR+ 
Sbjct: 6   ARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 65

Query: 72  PDGSENGEFLSLDLGGSKFRVLKVQVAE--EGKRHVQMESQFYPTPNEIIRGNGTELFEY 129
           P+GSE G+FLSLDLGG+ FRV+ V+V E  EG+  V+ + Q Y  P + + G    LF+Y
Sbjct: 66  PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDY 125

Query: 130 VADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRL 189
           +++C++DF+    +KHKKLPLG TFSFP R   +++G+LL+WTK FKA G +  +VV  L
Sbjct: 126 ISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLL 185

Query: 190 TKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVE 249
             A++R  D ++D++A+VNDTV TM++C Y+D  CEVG+I+GTG NACYME+M N++LVE
Sbjct: 186 RDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVE 245

Query: 250 GDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLI 309
           GDEGRMC+NTEWGAFGD G L++   E+DR +D  S NPG+QL+EK+I G Y+GELVRL+
Sbjct: 246 GDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLV 305

Query: 310 LLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCI 369
           LL++    LLF GE S  L T+G  ETR V+ +E           IL  LGL PS  DC 
Sbjct: 306 LLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCD 365

Query: 370 AVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHK 429
            V+  C  VS R+A++C+A LA ++ R+RE++  + +R TVG+DG++YK+HP + +R H 
Sbjct: 366 IVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHA 425

Query: 430 VVRKLVPSCDVRFLLSESGSTKGAAMVTAVASR 462
            VR+L PSC++ F+ SE GS +GAA+V+AVA +
Sbjct: 426 SVRRLTPSCEITFIESEEGSGRGAALVSAVACK 458


>gi|15967161 glucokinase isoform 3 [Homo sapiens]
          Length = 464

 Score =  494 bits (1273), Expect = e-139
 Identities = 237/450 (52%), Positives = 326/450 (72%), Gaps = 3/450 (0%)

Query: 461 SRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLP 520
           S++     Q++++LA FQL  E L  V  +M+ E++ GL+ ++H  A+V+MLPTYV   P
Sbjct: 6   SQLPQPNSQVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTP 65

Query: 521 DGTEKGKFLALDLGGTNFRVLLVKIRSGRR---SVRMYNKIFAIPLEIMQGTGEELFDHI 577
           +G+E G FL+LDLGGTNFRV+LVK+  G     SV+  +++++IP + M GT E LFD+I
Sbjct: 66  EGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYI 125

Query: 578 VQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLR 637
            +CI+DFLD   +K   LPLGFTFSFP R   IDKG L+ WTKGFKA+  EG +VV +LR
Sbjct: 126 SECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLR 185

Query: 638 EAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEG 697
           +AIKRR +F++D+VA+VNDTV TM++C YED  CE+G+I GTG N CYME+M+N+E+VEG
Sbjct: 186 DAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEG 245

Query: 698 GEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQIL 757
            EG+MC+NTEWG FGD+G +D+    YD  VDE S NPG+Q YEK+  G Y+GE+VR +L
Sbjct: 246 DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVL 305

Query: 758 IDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIV 817
           + L  + LLF G+ SE+LRTRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  +
Sbjct: 306 LRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDI 365

Query: 818 VKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQET 877
           V+  C +VS RAA +C AGLA ++ + RE +  + +RITVGVDG++YKLHP F      +
Sbjct: 366 VRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAS 425

Query: 878 VKELAPRCDVTFMLSEDGSGKGAALITAVA 907
           V+ L P C++TF+ SE+GSG+GAAL++AVA
Sbjct: 426 VRRLTPSCEITFIESEEGSGRGAALVSAVA 455



 Score =  469 bits (1208), Expect = e-132
 Identities = 221/444 (49%), Positives = 317/444 (71%), Gaps = 2/444 (0%)

Query: 21  KVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEF 80
           +V++ L   +L ++ L  +MRR + EM++GL  +T+  A+VKMLPT+VR+ P+GSE G+F
Sbjct: 14  QVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDF 73

Query: 81  LSLDLGGSKFRVLKVQVAE--EGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFM 138
           LSLDLGG+ FRV+ V+V E  EG+  V+ + Q Y  P + + G    LF+Y+++C++DF+
Sbjct: 74  LSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFL 133

Query: 139 KTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKD 198
               +KHKKLPLG TFSFP R   +++G+LL+WTK FKA G +  +VV  L  A++R  D
Sbjct: 134 DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 193

Query: 199 MDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCIN 258
            ++D++A+VNDTV TM++C Y+D  CEVG+I+GTG NACYME+M N++LVEGDEGRMC+N
Sbjct: 194 FEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVN 253

Query: 259 TEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGL 318
           TEWGAFGD G L++   E+DR +D  S NPG+QL+EK+I G Y+GELVRL+LL++    L
Sbjct: 254 TEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENL 313

Query: 319 LFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIV 378
           LF GE S  L T+G  ETR V+ +E           IL  LGL PS  DC  V+  C  V
Sbjct: 314 LFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESV 373

Query: 379 SFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSC 438
           S R+A++C+A LA ++ R+RE++  + +R TVG+DG++YK+HP + +R H  VR+L PSC
Sbjct: 374 STRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSC 433

Query: 439 DVRFLLSESGSTKGAAMVTAVASR 462
           ++ F+ SE GS +GAA+V+AVA +
Sbjct: 434 EITFIESEEGSGRGAALVSAVACK 457


>gi|15967159 glucokinase isoform 2 [Homo sapiens]
          Length = 466

 Score =  493 bits (1269), Expect = e-139
 Identities = 237/450 (52%), Positives = 325/450 (72%), Gaps = 3/450 (0%)

Query: 461 SRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLP 520
           S+ Q     ++++LA FQL  E L  V  +M+ E++ GL+ ++H  A+V+MLPTYV   P
Sbjct: 8   SQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTP 67

Query: 521 DGTEKGKFLALDLGGTNFRVLLVKIRSGRR---SVRMYNKIFAIPLEIMQGTGEELFDHI 577
           +G+E G FL+LDLGGTNFRV+LVK+  G     SV+  +++++IP + M GT E LFD+I
Sbjct: 68  EGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYI 127

Query: 578 VQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLR 637
            +CI+DFLD   +K   LPLGFTFSFP R   IDKG L+ WTKGFKA+  EG +VV +LR
Sbjct: 128 SECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLR 187

Query: 638 EAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEG 697
           +AIKRR +F++D+VA+VNDTV TM++C YED  CE+G+I GTG N CYME+M+N+E+VEG
Sbjct: 188 DAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEG 247

Query: 698 GEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQIL 757
            EG+MC+NTEWG FGD+G +D+    YD  VDE S NPG+Q YEK+  G Y+GE+VR +L
Sbjct: 248 DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVL 307

Query: 758 IDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIV 817
           + L  + LLF G+ SE+LRTRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  +
Sbjct: 308 LRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDI 367

Query: 818 VKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQET 877
           V+  C +VS RAA +C AGLA ++ + RE +  + +RITVGVDG++YKLHP F      +
Sbjct: 368 VRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAS 427

Query: 878 VKELAPRCDVTFMLSEDGSGKGAALITAVA 907
           V+ L P C++TF+ SE+GSG+GAAL++AVA
Sbjct: 428 VRRLTPSCEITFIESEEGSGRGAALVSAVA 457



 Score =  469 bits (1207), Expect = e-132
 Identities = 221/443 (49%), Positives = 316/443 (71%), Gaps = 2/443 (0%)

Query: 22  VDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEFL 81
           V++ L   +L ++ L  +MRR + EM++GL  +T+  A+VKMLPT+VR+ P+GSE G+FL
Sbjct: 17  VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76

Query: 82  SLDLGGSKFRVLKVQVAE--EGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMK 139
           SLDLGG+ FRV+ V+V E  EG+  V+ + Q Y  P + + G    LF+Y+++C++DF+ 
Sbjct: 77  SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136

Query: 140 TKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDM 199
              +KHKKLPLG TFSFP R   +++G+LL+WTK FKA G +  +VV  L  A++R  D 
Sbjct: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196

Query: 200 DVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINT 259
           ++D++A+VNDTV TM++C Y+D  CEVG+I+GTG NACYME+M N++LVEGDEGRMC+NT
Sbjct: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256

Query: 260 EWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLL 319
           EWGAFGD G L++   E+DR +D  S NPG+QL+EK+I G Y+GELVRL+LL++    LL
Sbjct: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316

Query: 320 FGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVS 379
           F GE S  L T+G  ETR V+ +E           IL  LGL PS  DC  V+  C  VS
Sbjct: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376

Query: 380 FRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCD 439
            R+A++C+A LA ++ R+RE++  + +R TVG+DG++YK+HP + +R H  VR+L PSC+
Sbjct: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436

Query: 440 VRFLLSESGSTKGAAMVTAVASR 462
           + F+ SE GS +GAA+V+AVA +
Sbjct: 437 ITFIESEEGSGRGAALVSAVACK 459


>gi|164663810 ribosomal modification protein rimK-like family member
           A [Homo sapiens]
          Length = 391

 Score = 33.1 bits (74), Expect = 1.2
 Identities = 32/125 (25%), Positives = 53/125 (42%), Gaps = 27/125 (21%)

Query: 577 IVQCIADFLDYMGLKGASLPLGFTFSFPCRQ---MSIDKGTLIGW------TKG------ 621
           I+ CI  F  +  L G  +P+  TFS+   +     ID+   +G+      T+G      
Sbjct: 105 ILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAV 164

Query: 622 FKATD-------CE--GEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTC---GYEDP 669
           F A D       C     DV  + ++ +K  +  D+ +V V    +G+M+ C   G    
Sbjct: 165 FLARDKHHLSDICHLIRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQS 224

Query: 670 NCEIG 674
           NC +G
Sbjct: 225 NCSLG 229


>gi|65301164 very low density lipoprotein receptor isoform b [Homo
           sapiens]
          Length = 845

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 27/92 (29%), Positives = 37/92 (40%), Gaps = 5/92 (5%)

Query: 627 CEG-EDVVDMLREA-IKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMC 684
           C+G ED VD   E    ++   + D V      V +   C   DP+CE G  +      C
Sbjct: 52  CDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCD-GDPDCEDG--SDESPEQC 108

Query: 685 YMEDMRNIEMVEGGEGKMCINTEWGGFGDNGC 716
           +M   R  E+  G     CI   W   G+N C
Sbjct: 109 HMRTCRIHEISCGAHSTQCIPVSWRCDGENDC 140


>gi|65301167 very low density lipoprotein receptor isoform a [Homo
           sapiens]
          Length = 873

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 27/92 (29%), Positives = 37/92 (40%), Gaps = 5/92 (5%)

Query: 627 CEG-EDVVDMLREA-IKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMC 684
           C+G ED VD   E    ++   + D V      V +   C   DP+CE G  +      C
Sbjct: 52  CDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCD-GDPDCEDG--SDESPEQC 108

Query: 685 YMEDMRNIEMVEGGEGKMCINTEWGGFGDNGC 716
           +M   R  E+  G     CI   W   G+N C
Sbjct: 109 HMRTCRIHEISCGAHSTQCIPVSWRCDGENDC 140


>gi|30425438 OAF homolog [Homo sapiens]
          Length = 273

 Score = 31.6 bits (70), Expect = 3.5
 Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 9/78 (11%)

Query: 841 VEKRREDQGLEHLRITVGVD---GTLYKLHPHFSRILQETVKELAPRC-DVTFMLSEDGS 896
           V +  E +GLEHL + V V+   G L  L PH   +  E V  +  R  DV F L +   
Sbjct: 128 VRQAEEVRGLEHLHMDVAVNFSQGAL--LSPHLHNVCAEAVDAIYTRQEDVRFWLEQ--- 182

Query: 897 GKGAALITAVAKRLQQAQ 914
           G  +++  A+ K  +QA+
Sbjct: 183 GVDSSVFEALPKASEQAE 200


>gi|46367787 poly(A) binding protein, cytoplasmic 1 [Homo sapiens]
          Length = 636

 Score = 31.2 bits (69), Expect = 4.6
 Identities = 27/105 (25%), Positives = 50/105 (47%), Gaps = 8/105 (7%)

Query: 425 KRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQL 484
           +RL  +  K  P+  V+ +  ESG +KG   V+    R +  +K +D +    +L  +Q+
Sbjct: 205 ERLKDLFGKFGPALSVKVMTDESGKSKGFGFVS--FERHEDAQKAVDEMNGK-ELNGKQI 261

Query: 485 VDVQAKMRAELEYGLKKKSHGLATVRM-----LPTYVCGLPDGTE 524
              +A+ + E +  LK+K   +   R+     +  YV  L DG +
Sbjct: 262 YVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGID 306


>gi|45238849 poly(A) binding protein, cytoplasmic 3 [Homo sapiens]
          Length = 631

 Score = 31.2 bits (69), Expect = 4.6
 Identities = 26/105 (24%), Positives = 50/105 (47%), Gaps = 8/105 (7%)

Query: 425 KRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQL 484
           +RL  +  K  P+  V+ +  ESG +KG   V+    R +  +K +D +    +L  +Q+
Sbjct: 205 ERLKDLFGKFGPALSVKVMTDESGKSKGFGFVS--FERHEDAQKAVDEMNGK-ELNGKQI 261

Query: 485 VDVQAKMRAELEYGLKK-----KSHGLATVRMLPTYVCGLPDGTE 524
              +A+ + E +  LK+     K   +   +++  YV  L DG +
Sbjct: 262 YVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGID 306


>gi|11693132 UPF2 regulator of nonsense transcripts homolog [Homo
           sapiens]
          Length = 1272

 Score = 30.8 bits (68), Expect = 6.0
 Identities = 19/74 (25%), Positives = 34/74 (45%), Gaps = 1/74 (1%)

Query: 122 NGTELFEYVADCLADFMKTK-DLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV 180
           NG  L +Y+A+ +A  ++ K  +      + L   F  R       +L  W K F+AR  
Sbjct: 194 NGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKE 253

Query: 181 QDTDVVSRLTKAMR 194
           + T  +++L   +R
Sbjct: 254 EKTPNITKLRTDLR 267


>gi|18375676 UPF2 regulator of nonsense transcripts homolog [Homo
           sapiens]
          Length = 1272

 Score = 30.8 bits (68), Expect = 6.0
 Identities = 19/74 (25%), Positives = 34/74 (45%), Gaps = 1/74 (1%)

Query: 122 NGTELFEYVADCLADFMKTK-DLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV 180
           NG  L +Y+A+ +A  ++ K  +      + L   F  R       +L  W K F+AR  
Sbjct: 194 NGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKE 253

Query: 181 QDTDVVSRLTKAMR 194
           + T  +++L   +R
Sbjct: 254 EKTPNITKLRTDLR 267


>gi|38201621 eukaryotic translation initiation factor 4 gamma, 1
           isoform 1 [Homo sapiens]
          Length = 1599

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%)

Query: 380 FRSANLCAAALAAILTRLRENKKVE------RLRTTVGMDGTLYKIHP---QYPKRLHKV 430
           F+   L  A +   + +L +N   E      RL TT+G D    K  P   QY  ++ K+
Sbjct: 906 FKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKI 965

Query: 431 VRKLVPSCDVRFLLSESGSTKGAAMV 456
           +++   S  +RF+L +    +G+  V
Sbjct: 966 IKEKKTSSRIRFMLQDVLDLRGSNWV 991


>gi|38201627 eukaryotic translation initiation factor 4 gamma, 1
           isoform 2 [Homo sapiens]
          Length = 1512

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%)

Query: 380 FRSANLCAAALAAILTRLRENKKVE------RLRTTVGMDGTLYKIHP---QYPKRLHKV 430
           F+   L  A +   + +L +N   E      RL TT+G D    K  P   QY  ++ K+
Sbjct: 819 FKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKI 878

Query: 431 VRKLVPSCDVRFLLSESGSTKGAAMV 456
           +++   S  +RF+L +    +G+  V
Sbjct: 879 IKEKKTSSRIRFMLQDVLDLRGSNWV 904


>gi|38201625 eukaryotic translation initiation factor 4 gamma, 1
           isoform 3 [Homo sapiens]
          Length = 1435

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%)

Query: 380 FRSANLCAAALAAILTRLRENKKVE------RLRTTVGMDGTLYKIHP---QYPKRLHKV 430
           F+   L  A +   + +L +N   E      RL TT+G D    K  P   QY  ++ K+
Sbjct: 742 FKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKI 801

Query: 431 VRKLVPSCDVRFLLSESGSTKGAAMV 456
           +++   S  +RF+L +    +G+  V
Sbjct: 802 IKEKKTSSRIRFMLQDVLDLRGSNWV 827


>gi|38201623 eukaryotic translation initiation factor 4 gamma, 1
           isoform 1 [Homo sapiens]
          Length = 1599

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%)

Query: 380 FRSANLCAAALAAILTRLRENKKVE------RLRTTVGMDGTLYKIHP---QYPKRLHKV 430
           F+   L  A +   + +L +N   E      RL TT+G D    K  P   QY  ++ K+
Sbjct: 906 FKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKI 965

Query: 431 VRKLVPSCDVRFLLSESGSTKGAAMV 456
           +++   S  +RF+L +    +G+  V
Sbjct: 966 IKEKKTSSRIRFMLQDVLDLRGSNWV 991


>gi|38201619 eukaryotic translation initiation factor 4 gamma, 1
           isoform 4 [Homo sapiens]
          Length = 1403

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%)

Query: 380 FRSANLCAAALAAILTRLRENKKVE------RLRTTVGMDGTLYKIHP---QYPKRLHKV 430
           F+   L  A +   + +L +N   E      RL TT+G D    K  P   QY  ++ K+
Sbjct: 710 FKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKI 769

Query: 431 VRKLVPSCDVRFLLSESGSTKGAAMV 456
           +++   S  +RF+L +    +G+  V
Sbjct: 770 IKEKKTSSRIRFMLQDVLDLRGSNWV 795


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,048,677
Number of Sequences: 37866
Number of extensions: 1391632
Number of successful extensions: 2786
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2725
Number of HSP's gapped (non-prelim): 41
length of query: 917
length of database: 18,247,518
effective HSP length: 111
effective length of query: 806
effective length of database: 14,044,392
effective search space: 11319779952
effective search space used: 11319779952
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.