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Search of human proteins with 156104862
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156104862 ankyrin repeat domain 38 [Homo sapiens]
(995 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156104862 ankyrin repeat domain 38 [Homo sapiens] 1998 0.0
gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Hom... 337 3e-92
gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Hom... 337 3e-92
gi|209969812 ankyrin repeat domain 25 [Homo sapiens] 273 6e-73
gi|31324547 ankyrin repeat domain 25 [Homo sapiens] 273 6e-73
gi|157504499 ankyrin repeat domain 47 [Homo sapiens] 258 1e-68
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 72 3e-12
gi|239754056 PREDICTED: ankyrin repeat and death domain containi... 68 4e-11
gi|239748583 PREDICTED: ankyrin repeat and death domain containi... 68 4e-11
gi|239742602 PREDICTED: ankyrin repeat and death domain containi... 68 4e-11
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 68 5e-11
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 67 6e-11
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 67 6e-11
gi|7657265 fem-1 homolog b [Homo sapiens] 66 1e-10
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 65 4e-10
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 65 4e-10
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 65 4e-10
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 65 4e-10
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 65 4e-10
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 65 4e-10
gi|18079216 CASK interacting protein 1 [Homo sapiens] 64 7e-10
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 64 7e-10
gi|134244285 Notch homolog 3 [Homo sapiens] 63 1e-09
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 63 1e-09
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 63 1e-09
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 63 1e-09
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 63 1e-09
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 63 1e-09
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 63 1e-09
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 63 2e-09
>gi|156104862 ankyrin repeat domain 38 [Homo sapiens]
Length = 995
Score = 1998 bits (5175), Expect = 0.0
Identities = 995/995 (100%), Positives = 995/995 (100%)
Query: 1 MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRR 60
MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRR
Sbjct: 1 MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRR 60
Query: 61 AKQAKFSTLPRNFSLPDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQAST 120
AKQAKFSTLPRNFSLPDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQAST
Sbjct: 61 AKQAKFSTLPRNFSLPDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQAST 120
Query: 121 SRSEVSYHRKALLAEATRQLEAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGL 180
SRSEVSYHRKALLAEATRQLEAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGL
Sbjct: 121 SRSEVSYHRKALLAEATRQLEAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGL 180
Query: 181 SLGPPAPPALPPLQGEGSVCDGTFEPAEGLAGFHSSSPRASTRIPELVQEGAEPPEGVVK 240
SLGPPAPPALPPLQGEGSVCDGTFEPAEGLAGFHSSSPRASTRIPELVQEGAEPPEGVVK
Sbjct: 181 SLGPPAPPALPPLQGEGSVCDGTFEPAEGLAGFHSSSPRASTRIPELVQEGAEPPEGVVK 240
Query: 241 VPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLL 300
VPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLL
Sbjct: 241 VPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLL 300
Query: 301 EEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRT 360
EEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRT
Sbjct: 301 EEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRT 360
Query: 361 EELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVH 420
EELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVH
Sbjct: 361 EELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVH 420
Query: 421 GLLTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLP 480
GLLTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLP
Sbjct: 421 GLLTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLP 480
Query: 481 QGPEQVLTSSVHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWGSDRKTPPAGREETSS 540
QGPEQVLTSSVHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWGSDRKTPPAGREETSS
Sbjct: 481 QGPEQVLTSSVHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWGSDRKTPPAGREETSS 540
Query: 541 NLPGKEHPGRPPSSPTDATIGQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQ 600
NLPGKEHPGRPPSSPTDATIGQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQ
Sbjct: 541 NLPGKEHPGRPPSSPTDATIGQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQ 600
Query: 601 SQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEISPSTSLKSIMKKKDYGFRAGGNGTK 660
SQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEISPSTSLKSIMKKKDYGFRAGGNGTK
Sbjct: 601 SQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEISPSTSLKSIMKKKDYGFRAGGNGTK 660
Query: 661 KNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQGI 720
KNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQGI
Sbjct: 661 KNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQGI 720
Query: 721 PEGTCHAAQESGPGEEVPHSKAERYKPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTI 780
PEGTCHAAQESGPGEEVPHSKAERYKPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTI
Sbjct: 721 PEGTCHAAQESGPGEEVPHSKAERYKPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTI 780
Query: 781 SQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIV 840
SQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIV
Sbjct: 781 SQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIV 840
Query: 841 KLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTAL 900
KLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTAL
Sbjct: 841 KLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTAL 900
Query: 901 MLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTD 960
MLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTD
Sbjct: 901 MLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTD 960
Query: 961 KAGRTALSIALKSPTHMEIAGLLRAHAEQGRSLGL 995
KAGRTALSIALKSPTHMEIAGLLRAHAEQGRSLGL
Sbjct: 961 KAGRTALSIALKSPTHMEIAGLLRAHAEQGRSLGL 995
>gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Homo
sapiens]
Length = 1194
Score = 337 bits (864), Expect = 3e-92
Identities = 213/520 (40%), Positives = 289/520 (55%), Gaps = 94/520 (18%)
Query: 552 PSSPTDATIG--QYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQSQLLSSLNL 609
P +P G Y+++IQ+LL EQ L Y ELA A +P S++ S+ SQL+S+L+
Sbjct: 655 PQAPLGMMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSS 714
Query: 610 LLSAY-----------------------------------------SAQAHPPKEPPASS 628
+ S S+Q P++ +S
Sbjct: 715 INSVMKSASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTS 774
Query: 629 SSPPVE-----------ISP------------------STSLKSIMKKKDYGFRAGGNGT 659
P+ +SP ++LKSIMKKKD NG
Sbjct: 775 EGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGN--KDSNGA 832
Query: 660 KKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQG 719
KKNLQFVG+NGGYETTSS+++S ++S S SE++ +CD ++ ++ E +G
Sbjct: 833 KKNLQFVGINGGYETTSSDDSSSDES-----SSSESDDECDVIEYPLEEEEEEEDEDTRG 887
Query: 720 IPEGTCHAAQESG----------PGEEVPHSKAE---RYKPSEEFLNACRALSQHLPETG 766
+ EG HA G +E K E RY+ SE+ L+AC L + +
Sbjct: 888 MAEGH-HAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPK 946
Query: 767 TTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNT 826
T + +R LNT+ EWFRVSS+KS+ PA+V Y+ + SP L+ ++NLAD NGNT
Sbjct: 947 ALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNT 1006
Query: 827 ALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG 886
ALHYSVSHSNF IVKLLL+ VCNVDHQNKAGYT +M+ LA+ E +DM +V +L G
Sbjct: 1007 ALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG 1066
Query: 887 NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVR 946
+VN +A+Q GQTALML VSH R DMV+ LL+C ADVN+QD +GS+ALM A HG+V++V+
Sbjct: 1067 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1126
Query: 947 LLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
LLLA P C+ L D G TALSIAL++ H +IA LL AH
Sbjct: 1127 LLLAQPGCNGHLEDNDGSTALSIALEA-GHKDIAVLLYAH 1165
Score = 30.8 bits (68), Expect = 6.6
Identities = 23/83 (27%), Positives = 43/83 (51%), Gaps = 12/83 (14%)
Query: 318 VDMRSIGIRVTEESLGL-------ARVDPGSISSLKQQVSALEGELSGRTEELAQVRTAL 370
V+MR+ G+ VTE LG+ + +I SLK+++ LE +L T + +
Sbjct: 273 VEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHD-----REM 327
Query: 371 QQQEEEIKAREQRIRELEFTVAQ 393
+ ++E++A R + + T+AQ
Sbjct: 328 TKLKQELQAAGSRKKVDKATMAQ 350
>gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Homo
sapiens]
Length = 1352
Score = 337 bits (864), Expect = 3e-92
Identities = 213/520 (40%), Positives = 289/520 (55%), Gaps = 94/520 (18%)
Query: 552 PSSPTDATIG--QYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQSQLLSSLNL 609
P +P G Y+++IQ+LL EQ L Y ELA A +P S++ S+ SQL+S+L+
Sbjct: 813 PQAPLGMMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSS 872
Query: 610 LLSAY-----------------------------------------SAQAHPPKEPPASS 628
+ S S+Q P++ +S
Sbjct: 873 INSVMKSASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTS 932
Query: 629 SSPPVE-----------ISP------------------STSLKSIMKKKDYGFRAGGNGT 659
P+ +SP ++LKSIMKKKD NG
Sbjct: 933 EGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGN--KDSNGA 990
Query: 660 KKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQG 719
KKNLQFVG+NGGYETTSS+++S ++S S SE++ +CD ++ ++ E +G
Sbjct: 991 KKNLQFVGINGGYETTSSDDSSSDES-----SSSESDDECDVIEYPLEEEEEEEDEDTRG 1045
Query: 720 IPEGTCHAAQESG----------PGEEVPHSKAE---RYKPSEEFLNACRALSQHLPETG 766
+ EG HA G +E K E RY+ SE+ L+AC L + +
Sbjct: 1046 MAEGH-HAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPK 1104
Query: 767 TTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNT 826
T + +R LNT+ EWFRVSS+KS+ PA+V Y+ + SP L+ ++NLAD NGNT
Sbjct: 1105 ALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNT 1164
Query: 827 ALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG 886
ALHYSVSHSNF IVKLLL+ VCNVDHQNKAGYT +M+ LA+ E +DM +V +L G
Sbjct: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG 1224
Query: 887 NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVR 946
+VN +A+Q GQTALML VSH R DMV+ LL+C ADVN+QD +GS+ALM A HG+V++V+
Sbjct: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
Query: 947 LLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
LLLA P C+ L D G TALSIAL++ H +IA LL AH
Sbjct: 1285 LLLAQPGCNGHLEDNDGSTALSIALEA-GHKDIAVLLYAH 1323
Score = 72.8 bits (177), Expect = 2e-12
Identities = 36/62 (58%), Positives = 45/62 (72%), Gaps = 2/62 (3%)
Query: 13 GDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRN 72
GD++K+ + PY VETPYG+ LDLDFLKYVDDI+KGNTIKR+ I +R K + PR
Sbjct: 21 GDQDKE--QKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRLNIQKRRKPSVPCPEPRT 78
Query: 73 FS 74
S
Sbjct: 79 TS 80
Score = 30.8 bits (68), Expect = 6.6
Identities = 23/83 (27%), Positives = 43/83 (51%), Gaps = 12/83 (14%)
Query: 318 VDMRSIGIRVTEESLGL-------ARVDPGSISSLKQQVSALEGELSGRTEELAQVRTAL 370
V+MR+ G+ VTE LG+ + +I SLK+++ LE +L T + +
Sbjct: 431 VEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHD-----REM 485
Query: 371 QQQEEEIKAREQRIRELEFTVAQ 393
+ ++E++A R + + T+AQ
Sbjct: 486 TKLKQELQAAGSRKKVDKATMAQ 508
>gi|209969812 ankyrin repeat domain 25 [Homo sapiens]
Length = 851
Score = 273 bits (698), Expect = 6e-73
Identities = 171/466 (36%), Positives = 264/466 (56%), Gaps = 40/466 (8%)
Query: 548 PGRPPSSPT-------------DATIGQYVKKIQELLQEQWNCL-EHGYPELA--SAIKQ 591
PGRP S P A V ++++ + +C G PE+ S+
Sbjct: 370 PGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPEVPAESSSSP 429
Query: 592 PASKLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEIS-----PSTSLKSIMK 646
P S+++S+ S+ Q +EP ++S E + P ++SIMK
Sbjct: 430 PGSEVASLTQPEKST-----GRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVRSIMK 484
Query: 647 KKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKH 706
+K+ A +++LQFVGVNGGYE++S + ++ E+ + D +++EA + +
Sbjct: 485 RKEEV--ADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPS-- 540
Query: 707 VKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAE---------RYKPSEEFLNACRA 757
V +A AG + + Q S + +P ++ R + S + ++AC A
Sbjct: 541 VAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLA 600
Query: 758 LSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLV 817
L ++L T++ L+ + T+ QEW R++ R + P +V +L + S L +V
Sbjct: 601 LEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVV 660
Query: 818 NLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMA 877
N+AD NGNTALHYSVSH+NF +V+ LL++GVC VD QN+AGY+ +M+T LA+ +T +D+
Sbjct: 661 NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE 720
Query: 878 VVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVAC 937
V +L R GN+N +A+Q GQTALML VSH R D+V+ALL+C+ADVN+QD DGS+ALM AC
Sbjct: 721 TVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCAC 780
Query: 938 HHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
HG+ ++ LLLA P+CD SLTD+ G TAL +AL + EIA +L
Sbjct: 781 EHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDA-GQSEIASML 825
Score = 78.2 bits (191), Expect = 4e-14
Identities = 106/363 (29%), Positives = 159/363 (43%), Gaps = 77/363 (21%)
Query: 17 KDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLP 76
KDP PYSVETPYG+ LDLDFLKYVDDIEKG+T++R+ + RR + S+LPR
Sbjct: 26 KDPDP--PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRR---PRLSSLPRG---- 76
Query: 77 DSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEA 136
G+ + L + + R ++ + P G A +R + + L +A
Sbjct: 77 -PGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYG----ALETRGGFNPRVERTLLDA 131
Query: 137 TRQLE--AAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALPPLQ 194
R+LE AA P GS P A+ A+L+ G+ L PP P
Sbjct: 132 RRRLEDQAATPTG----LGSLTPS---AAGSTASLV--------GVGLPPPTP------- 169
Query: 195 GEGSVCDGTFEPAEG-LAGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFS 253
S P+ G LA A ++ +L ++ VK+ +P+
Sbjct: 170 -RSSGLSTPVPPSAGHLAHVREQMAGALRKLRQLEEQ--------VKL---IPV------ 211
Query: 254 FQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP 313
Q L VL++++ + + F G PT +EL L+ + PP
Sbjct: 212 LQVKLSVLQEEKRQLTVQLKSQKFL-GHPTAGR-------GRSELCLDLPD------PPE 257
Query: 314 PPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEEL--AQVRTALQ 371
PV ++ RS+G V E LG+ P ++L +V+ LE +L +EL AQ R A
Sbjct: 258 DPVALETRSVGTWVRERDLGM----PDGEAALAAKVAVLETQLKKALQELQAAQARQADP 313
Query: 372 QQE 374
Q +
Sbjct: 314 QPQ 316
>gi|31324547 ankyrin repeat domain 25 [Homo sapiens]
Length = 851
Score = 273 bits (698), Expect = 6e-73
Identities = 171/466 (36%), Positives = 264/466 (56%), Gaps = 40/466 (8%)
Query: 548 PGRPPSSPT-------------DATIGQYVKKIQELLQEQWNCL-EHGYPELA--SAIKQ 591
PGRP S P A V ++++ + +C G PE+ S+
Sbjct: 370 PGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPEVPAESSSSP 429
Query: 592 PASKLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEIS-----PSTSLKSIMK 646
P S+++S+ S+ Q +EP ++S E + P ++SIMK
Sbjct: 430 PGSEVASLTQPEKST-----GRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVRSIMK 484
Query: 647 KKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKH 706
+K+ A +++LQFVGVNGGYE++S + ++ E+ + D +++EA + +
Sbjct: 485 RKEEV--ADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPS-- 540
Query: 707 VKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAE---------RYKPSEEFLNACRA 757
V +A AG + + Q S + +P ++ R + S + ++AC A
Sbjct: 541 VAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLA 600
Query: 758 LSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLV 817
L ++L T++ L+ + T+ QEW R++ R + P +V +L + S L +V
Sbjct: 601 LEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVV 660
Query: 818 NLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMA 877
N+AD NGNTALHYSVSH+NF +V+ LL++GVC VD QN+AGY+ +M+T LA+ +T +D+
Sbjct: 661 NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE 720
Query: 878 VVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVAC 937
V +L R GN+N +A+Q GQTALML VSH R D+V+ALL+C+ADVN+QD DGS+ALM AC
Sbjct: 721 TVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCAC 780
Query: 938 HHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
HG+ ++ LLLA P+CD SLTD+ G TAL +AL + EIA +L
Sbjct: 781 EHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDA-GQSEIASML 825
Score = 78.2 bits (191), Expect = 4e-14
Identities = 106/363 (29%), Positives = 159/363 (43%), Gaps = 77/363 (21%)
Query: 17 KDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLP 76
KDP PYSVETPYG+ LDLDFLKYVDDIEKG+T++R+ + RR + S+LPR
Sbjct: 26 KDPDP--PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRR---PRLSSLPRG---- 76
Query: 77 DSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEA 136
G+ + L + + R ++ + P G A +R + + L +A
Sbjct: 77 -PGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYG----ALETRGGFNPRVERTLLDA 131
Query: 137 TRQLE--AAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALPPLQ 194
R+LE AA P GS P A+ A+L+ G+ L PP P
Sbjct: 132 RRRLEDQAATPTG----LGSLTPS---AAGSTASLV--------GVGLPPPTP------- 169
Query: 195 GEGSVCDGTFEPAEG-LAGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFS 253
S P+ G LA A ++ +L ++ VK+ +P+
Sbjct: 170 -RSSGLSTPVPPSAGHLAHVREQMAGALRKLRQLEEQ--------VKL---IPV------ 211
Query: 254 FQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP 313
Q L VL++++ + + F G PT +EL L+ + PP
Sbjct: 212 LQVKLSVLQEEKRQLTVQLKSQKFL-GHPTAGR-------GRSELCLDLPD------PPE 257
Query: 314 PPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEEL--AQVRTALQ 371
PV ++ RS+G V E LG+ P ++L +V+ LE +L +EL AQ R A
Sbjct: 258 DPVALETRSVGTWVRERDLGM----PDGEAALAAKVAVLETQLKKALQELQAAQARQADP 313
Query: 372 QQE 374
Q +
Sbjct: 314 QPQ 316
>gi|157504499 ankyrin repeat domain 47 [Homo sapiens]
Length = 821
Score = 258 bits (660), Expect = 1e-68
Identities = 228/714 (31%), Positives = 321/714 (44%), Gaps = 64/714 (8%)
Query: 305 LNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEELA 364
L + + P PV +R T L LA+ + S + + G SGR+
Sbjct: 114 LLMQPLSPRAPVRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRSPRG--SGRSSPAP 171
Query: 365 QVRTA------LQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDP 418
+ A LQ E++ A +R+RELE L Q A + + P
Sbjct: 172 NLAPASPGPAQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLAGRAQP 231
Query: 419 VHGLLTRESCDKGIEVNLLGS-MESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQL 477
DK ++ L + + G R + PDG G A +VL ++
Sbjct: 232 EPDGEAETRPDKLAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSEGALQVLDGEV 291
Query: 478 SLPQGPEQVLTSSVHSFLSTELRIEEAGTE-QEGGPQGGTRGAGGFLWGSDRKT--PPAG 534
G Q + + T +A E +E G + W ++ P A
Sbjct: 292 GSLDGTPQTREVAAEAVPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAA 351
Query: 535 REETSSNLPGKEHPGRPPSSPTDATIGQYVKKIQELLQEQWNCLEHGYPELASAIKQPAS 594
E EH + + ELL+ + LE A +
Sbjct: 352 ERELELLRASLEHQ----------------RGVSELLRGRLRELEEAREAAEEAAAGARA 395
Query: 595 KLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPA--SSSSPPV-----EISPSTSLKSIMKK 647
+L +Q S + +AQ P E P+ SSP ++P+ LKSIMKK
Sbjct: 396 QLREATTQTPWSC----AEKAAQTESPAEAPSLTQESSPGSMDGDRAVAPAGILKSIMKK 451
Query: 648 KDYGFRAGGNGTKKNLQFVGV-NGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKH 706
+D A + K+LQFVGV NG YE++SSE+ S D E+ D
Sbjct: 452 RDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGD--- 508
Query: 707 VKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAE-------RYKPSEEFLNACRALS 759
++G G GT + P ++AE R + S AC AL
Sbjct: 509 --------DSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQVAQGRCELSPRLREACVALQ 560
Query: 760 QHLPET-GTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVN 818
+ L G +D ++ ++QEWFRVSS++ S VA L V+ P L +VN
Sbjct: 561 RQLSRPRGVASDG---GAVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVN 617
Query: 819 LADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASA-ETNEDMA 877
LAD NGNTALHYSVSH N +I LLL+TG C V+ QN+AGY+A+M+ L S + EDMA
Sbjct: 618 LADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMA 677
Query: 878 VVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVAC 937
VV +L G+VN +A+Q GQTALML +SH R+DMV LL+C ADVN QD DG++ALM A
Sbjct: 678 VVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCAS 737
Query: 938 HHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGR 991
+G +D VRLLL P CD ++ D G +AL+IAL++ E+A LL AH G+
Sbjct: 738 EYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQD-EVAALLHAHLSSGQ 790
Score = 75.1 bits (183), Expect = 3e-13
Identities = 62/176 (35%), Positives = 83/176 (47%), Gaps = 30/176 (17%)
Query: 22 SHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLPDSGAR 81
S PYSVETPYGFHLDLDFLKY++++E+G P RRA S PR +GAR
Sbjct: 31 SSPYSVETPYGFHLDLDFLKYIEELERG------PAARRAPGPPTSRRPRAPRPGLAGAR 84
Query: 82 PPAAPPLQNWSPVVPREASLGTQE------QNQSPPLGNAPQASTSRSEVSYHR-KALLA 134
P A W+ SL + + +Q P G Q + R+ V R + L
Sbjct: 85 SPGA-----WT----SSESLASDDGGAPGILSQGAPSGLLMQPLSPRAPVRNPRVEHTLR 135
Query: 135 EATRQLEAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPAL 190
E +R+LE A+ + + G G P+ R S R+S P L+ P P L
Sbjct: 136 ETSRRLELAQTHERAPSPGRGVPRSPRGS--------GRSSPAPNLAPASPGPAQL 183
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 72.0 bits (175), Expect = 3e-12
Identities = 51/154 (33%), Positives = 81/154 (52%), Gaps = 9/154 (5%)
Query: 818 NLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMA 877
N+ D T LH + H +S+ K L E G CNV+ +N+ G T ++ ASA D+
Sbjct: 472 NIQDKEEETPLHCAAWHGYYSVAKALCEAG-CNVNIKNREGETPLLT---ASARGYHDIV 527
Query: 878 VVWKLLREGNVNIQAT-QGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 936
+ L E ++ A + G AL L V + ++++ LLS V+ QD G++ L VA
Sbjct: 528 ---ECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 584
Query: 937 CHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
C GN+ +V + L C+ +++K GRT L +A
Sbjct: 585 CKDGNMPIV-VALCEANCNLDISNKYGRTPLHLA 617
Score = 51.2 bits (121), Expect = 5e-06
Identities = 52/200 (26%), Positives = 88/200 (44%), Gaps = 46/200 (23%)
Query: 787 VSSRKSSSPAVVAS---YLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLL 843
+ +R+ +P + AS Y V+ + H L N D +G+ ALH +V ++K L
Sbjct: 506 IKNREGETPLLTASARGYHDIVECLAEHGADL--NACDKDGHIALHLAVRRCQMEVIKTL 563
Query: 844 LETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLG 903
L G C VD+Q++ G T + + ++GN+ I
Sbjct: 564 LSQG-CFVDYQDRHGNTPLHVA-----------------CKDGNMPI------------- 592
Query: 904 VSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAG 963
V AL ++++ + G + L +A ++G +D+VR L A +LT G
Sbjct: 593 --------VVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTD-G 643
Query: 964 RTALSIALKSPTHMEIAGLL 983
+TA +A +S H +AGLL
Sbjct: 644 KTAEDLA-RSEQHEHVAGLL 662
Score = 48.9 bits (115), Expect = 2e-05
Identities = 59/256 (23%), Positives = 109/256 (42%), Gaps = 26/256 (10%)
Query: 743 ERYKPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYL 802
+++K S ++ C+ LS+ + ++ + +S +T+ +E V A++ +
Sbjct: 303 KKWKQSVRLISLCQRLSRSFL---SRSNMSVARSDDTLDEEDSFVMK------AIIHAIN 353
Query: 803 HEVQPHSPHFLKLL----VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAG 858
+ P H L L VN + +G L + N I++LL++ G +D Q+K G
Sbjct: 354 DDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRG-SRIDVQDKGG 412
Query: 859 YTAVMITPLASAETNEDMAVVWKLLREGNVNIQAT-QGGQTALMLGVSHDREDMVQALLS 917
AV A+ + D K L E + + G+ AL + + D+ Q L S
Sbjct: 413 SNAVY---WAARHGHVDTL---KFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCS 466
Query: 918 CQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHM 977
++ N+QD + + L A HG + + L C+ ++ ++ G T L A H
Sbjct: 467 FGSNPNIQDKEEETPLHCAAWHGYYSVAK-ALCEAGCNVNIKNREGETPLLTASARGYH- 524
Query: 978 EIAGLLRAHAEQGRSL 993
++ AE G L
Sbjct: 525 ---DIVECLAEHGADL 537
>gi|239754056 PREDICTED: ankyrin repeat and death domain containing
1B [Homo sapiens]
Length = 524
Score = 68.2 bits (165), Expect = 4e-11
Identities = 53/161 (32%), Positives = 87/161 (54%), Gaps = 10/161 (6%)
Query: 824 GNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLL 883
GNTALH + H + V++LL +++ N+ +++ I A N ++V LL
Sbjct: 280 GNTALHLAAKHGHSPAVQVLLAQWQ-DINEMNELNISSLQI-----ATRNGHASLVNFLL 333
Query: 884 REGNVNI-QATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNV 942
E NV++ Q + ++ L L V ++ +V +LLS Q D+++ + + L VA GNV
Sbjct: 334 SE-NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNV 392
Query: 943 DLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
+LV LL CD DK G+TAL++A +S H + G+L
Sbjct: 393 ELVETLL-KAGCDLKAVDKQGKTALAVASRS-NHSLVVGML 431
Score = 45.4 bits (106), Expect = 3e-04
Identities = 34/137 (24%), Positives = 64/137 (46%), Gaps = 8/137 (5%)
Query: 814 KLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETN 873
K+ +N+ ++ TALH++V ++ S V LL+ VD +K G T + + A +
Sbjct: 91 KVNINVVNNMNRTALHFAVGRNHLSAVDFLLK-HKARVDVADKHGLTVIHL-----AAWS 144
Query: 874 EDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLS--CQADVNLQDHDGSS 931
+ V+ L++ G Q G +AL + +V+ L+ D+N D G
Sbjct: 145 GSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRK 204
Query: 932 ALMVACHHGNVDLVRLL 948
++A G+V+++ L
Sbjct: 205 PFLLAAERGHVEMIEKL 221
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/62 (35%), Positives = 32/62 (51%)
Query: 889 NIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLL 948
++ QGG TAL L H VQ LL+ D+N + S+L +A +G+ LV L
Sbjct: 273 SVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFL 332
Query: 949 LA 950
L+
Sbjct: 333 LS 334
>gi|239748583 PREDICTED: ankyrin repeat and death domain containing
1B [Homo sapiens]
Length = 524
Score = 68.2 bits (165), Expect = 4e-11
Identities = 53/161 (32%), Positives = 87/161 (54%), Gaps = 10/161 (6%)
Query: 824 GNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLL 883
GNTALH + H + V++LL +++ N+ +++ I A N ++V LL
Sbjct: 280 GNTALHLAAKHGHSPAVQVLLAQWQ-DINEMNELNISSLQI-----ATRNGHASLVNFLL 333
Query: 884 REGNVNI-QATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNV 942
E NV++ Q + ++ L L V ++ +V +LLS Q D+++ + + L VA GNV
Sbjct: 334 SE-NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNV 392
Query: 943 DLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
+LV LL CD DK G+TAL++A +S H + G+L
Sbjct: 393 ELVETLL-KAGCDLKAVDKQGKTALAVASRS-NHSLVVGML 431
Score = 45.4 bits (106), Expect = 3e-04
Identities = 34/137 (24%), Positives = 64/137 (46%), Gaps = 8/137 (5%)
Query: 814 KLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETN 873
K+ +N+ ++ TALH++V ++ S V LL+ VD +K G T + + A +
Sbjct: 91 KVNINVVNNMNRTALHFAVGRNHLSAVDFLLK-HKARVDVADKHGLTVIHL-----AAWS 144
Query: 874 EDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLS--CQADVNLQDHDGSS 931
+ V+ L++ G Q G +AL + +V+ L+ D+N D G
Sbjct: 145 GSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRK 204
Query: 932 ALMVACHHGNVDLVRLL 948
++A G+V+++ L
Sbjct: 205 PFLLAAERGHVEMIEKL 221
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/62 (35%), Positives = 32/62 (51%)
Query: 889 NIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLL 948
++ QGG TAL L H VQ LL+ D+N + S+L +A +G+ LV L
Sbjct: 273 SVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFL 332
Query: 949 LA 950
L+
Sbjct: 333 LS 334
>gi|239742602 PREDICTED: ankyrin repeat and death domain containing
1B [Homo sapiens]
Length = 607
Score = 68.2 bits (165), Expect = 4e-11
Identities = 53/161 (32%), Positives = 87/161 (54%), Gaps = 10/161 (6%)
Query: 824 GNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLL 883
GNTALH + H + V++LL +++ N+ +++ I A N ++V LL
Sbjct: 280 GNTALHLAAKHGHSPAVQVLLAQWQ-DINEMNELNISSLQI-----ATRNGHASLVNFLL 333
Query: 884 REGNVNI-QATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNV 942
E NV++ Q + ++ L L V ++ +V +LLS Q D+++ + + L VA GNV
Sbjct: 334 SE-NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNV 392
Query: 943 DLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
+LV LL CD DK G+TAL++A +S H + G+L
Sbjct: 393 ELVETLL-KAGCDLKAVDKQGKTALAVASRS-NHSLVVGML 431
Score = 45.4 bits (106), Expect = 3e-04
Identities = 34/137 (24%), Positives = 64/137 (46%), Gaps = 8/137 (5%)
Query: 814 KLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETN 873
K+ +N+ ++ TALH++V ++ S V LL+ VD +K G T + + A +
Sbjct: 91 KVNINVVNNMNRTALHFAVGRNHLSAVDFLLK-HKARVDVADKHGLTVIHL-----AAWS 144
Query: 874 EDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLS--CQADVNLQDHDGSS 931
+ V+ L++ G Q G +AL + +V+ L+ D+N D G
Sbjct: 145 GSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRK 204
Query: 932 ALMVACHHGNVDLVRLL 948
++A G+V+++ L
Sbjct: 205 PFLLAAERGHVEMIEKL 221
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/62 (35%), Positives = 32/62 (51%)
Query: 889 NIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLL 948
++ QGG TAL L H VQ LL+ D+N + S+L +A +G+ LV L
Sbjct: 273 SVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFL 332
Query: 949 LA 950
L+
Sbjct: 333 LS 334
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 67.8 bits (164), Expect = 5e-11
Identities = 51/154 (33%), Positives = 76/154 (49%), Gaps = 2/154 (1%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN AD+ G TAL + + IV+ LL+ G V+H++ G TA+ + L +
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGA-EVNHEDVDGRTALSVAALCVPASKGHA 728
Query: 877 AVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 936
+VV L+ G + G T L++ D+V LL ADV+ D++G + L+ A
Sbjct: 729 SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788
Query: 937 CHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
G+ +V LL A S+ D GRT LSIA
Sbjct: 789 ASMGHASVVNTLLFWGAAVDSI-DSEGRTVLSIA 821
Score = 64.3 bits (155), Expect = 5e-10
Identities = 55/171 (32%), Positives = 83/171 (48%), Gaps = 11/171 (6%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
+ + D +G+T L + + +V L+ G N++H ++ G+TA L SA
Sbjct: 571 LEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA-NINHTDQDGWTA-----LRSAAWGGHT 624
Query: 877 AVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 936
VV LL G A +TAL ED+V LL A+VN D++G +AL+ A
Sbjct: 625 EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAA 684
Query: 937 CHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIAL----KSPTHMEIAGLL 983
+ G+ ++V LL H A + + D GRTALS+A S H + LL
Sbjct: 685 AYMGHREIVEHLLDHGA-EVNHEDVDGRTALSVAALCVPASKGHASVVSLL 734
Score = 63.5 bits (153), Expect = 9e-10
Identities = 45/153 (29%), Positives = 75/153 (49%), Gaps = 7/153 (4%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
V+ D G T L + + N +V+ LL+ G+ + +H++ AG+T PL A
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL-DENHRDDAGWT-----PLHMAAFEGHR 860
Query: 877 AVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 936
+ L+ +G + G+ +L D VQ LL +++++ + +DG +AL VA
Sbjct: 861 LICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVA 920
Query: 937 CHHGNVDLVRLLLAHPACDSSLTDKAGRTALSI 969
G+ D+V LL +H A D + D GR L I
Sbjct: 921 ALEGHRDIVELLFSHGA-DVNCKDADGRPTLYI 952
Score = 62.8 bits (151), Expect = 2e-09
Identities = 54/160 (33%), Positives = 80/160 (50%), Gaps = 14/160 (8%)
Query: 817 VNLADHNGNTALHYSV-----SHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAE 871
VN D +G TAL + S + S+V LL++ G VDH +K G T +++ A+ E
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGA-EVDHCDKDGMTPLLV---AAYE 758
Query: 872 TNEDMAVVWKLLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGS 930
+ D+ LL EG ++ T G+T L+ S +V LL A V+ D +G
Sbjct: 759 GHVDVV---DLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR 815
Query: 931 SALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
+ L +A GNV++VR LL D + D AG T L +A
Sbjct: 816 TVLSIASAQGNVEVVRTLLDR-GLDENHRDDAGWTPLHMA 854
Score = 61.2 bits (147), Expect = 5e-09
Identities = 50/166 (30%), Positives = 82/166 (49%), Gaps = 10/166 (6%)
Query: 822 HNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWK 881
++G AL + + IV+LL G +V+ ++ G + I L E+ + +
Sbjct: 911 YDGRNALRVAALEGHRDIVELLFSHGA-DVNCKDADGRPTLYILAL------ENQLTMAE 963
Query: 882 LLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHG 940
E N++A+ G+TAL + +MVQ L++ ADVN D++ SAL A G
Sbjct: 964 YFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQG 1023
Query: 941 NVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
+V +V+LL+ H A T G TAL IA + H+++ +L H
Sbjct: 1024 HVKVVQLLIEHGAVVDH-TCNQGATALCIAAQE-GHIDVVQVLLEH 1067
Score = 55.8 bits (133), Expect = 2e-07
Identities = 46/162 (28%), Positives = 71/162 (43%), Gaps = 21/162 (12%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLL--ETGVCNVDHQNKAGYTAVMITPLASAETNE 874
V +D G TALH S + +V++L+ V D++ ++ L SA
Sbjct: 972 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSA--------LQSAAWQG 1023
Query: 875 DMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALM 934
+ VV L+ G V G TAL + D+VQ LL AD N D G +A+
Sbjct: 1024 HVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMR 1083
Query: 935 VACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTH 976
VA +G+ +++LL +K G ++L+ SP H
Sbjct: 1084 VAAKNGHSQIIKLL-----------EKYGASSLNGCSPSPVH 1114
Score = 44.3 bits (103), Expect = 6e-04
Identities = 43/154 (27%), Positives = 68/154 (44%), Gaps = 7/154 (4%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
V+ D +G T L + + +V LLLE G +VDH + G T PL +A +
Sbjct: 741 VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGA-DVDHTDNNGRT-----PLLAAASMGHA 794
Query: 877 AVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 936
+VV LL G G+T L + + ++V+ LL D N +D G + L +A
Sbjct: 795 SVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMA 854
Query: 937 CHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
G+ + L+ A + + D GR +A
Sbjct: 855 AFEGHRLICEALIEQGARTNEI-DNDGRIPFILA 887
Score = 43.9 bits (102), Expect = 8e-04
Identities = 28/94 (29%), Positives = 54/94 (57%), Gaps = 2/94 (2%)
Query: 879 VWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACH 938
V +LL + ++ + + +T+ ++ + +RED ++ LL A VN D +G + L A +
Sbjct: 496 VLQLLVKAGAHVNS-EDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAY 554
Query: 939 HGNVDLVRLLLAHPACDSSLTDKAGRTALSIALK 972
G++D+V LL++ A D + D G T L++A +
Sbjct: 555 SGSLDVVNLLVSRGA-DLEIEDAHGHTPLTLAAR 587
Score = 36.2 bits (82), Expect = 0.16
Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 5/91 (5%)
Query: 882 LLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGN 941
LL G Q G+T L D+V L+S AD+ ++D G + L +A G+
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
Query: 942 VDLVRLLLAHPACDSSL--TDKAGRTALSIA 970
+V L+ C +++ TD+ G TAL A
Sbjct: 591 TKVVNCLI---GCGANINHTDQDGWTALRSA 618
Score = 35.4 bits (80), Expect = 0.27
Identities = 39/186 (20%), Positives = 78/186 (41%), Gaps = 23/186 (12%)
Query: 328 TEESLGLARVDPGSI---SSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRI 384
T +SLG + P S S +K + + + G++E A+ +A ++ ++ + + ++
Sbjct: 1238 TTQSLGQSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSAGKKAKQS-NSSQPKV 1296
Query: 385 RELEFTVAQLEGQFHQENAK------DTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLG 438
E E T G + + Q +M+ S + I +
Sbjct: 1297 LEYEMTQFDRRGPIAKSGTAAPPKQMPAESQCKIMI-----------PSAQQEIGRSQQQ 1345
Query: 439 SMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLPQGPEQVLTSSVHSFLSTE 498
+ + G + + NG++ P+ H Q NQ RV +P+ +G ++VL S TE
Sbjct: 1346 FLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVSVPRTMQDRGHQEVLEGYPSS--ETE 1403
Query: 499 LRIEEA 504
L +++A
Sbjct: 1404 LSLKQA 1409
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 67.4 bits (163), Expect = 6e-11
Identities = 59/178 (33%), Positives = 90/178 (50%), Gaps = 12/178 (6%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN GNTAL Y+ + +VK+LLE+G DH N+ G+T PL A + +
Sbjct: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH-NENGHT-----PLMEAGSAGHV 380
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
V LL G +N + + ++AL L +MV+ LL AD + + +ALM
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSL 993
AC G+V++ RLLL A ++ + + L++A H+E+A LL E+G SL
Sbjct: 441 ACMDGHVEVARLLLDSGA-QVNMPADSFESPLTLA-ACGGHVELAALL---IERGASL 493
Score = 52.8 bits (125), Expect = 2e-06
Identities = 50/168 (29%), Positives = 85/168 (50%), Gaps = 12/168 (7%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN+ + + L + + + LL+E G +++ N GYT +M A+ E +E+M
Sbjct: 460 VNMPADSFESPLTLAACGGHVELAALLIERGA-SLEEVNDEGYTPLME---AAREGHEEM 515
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+ LL +G N+N Q + +TAL L ++ L+ AD+ L S+ LM
Sbjct: 516 VAL--LLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLME 570
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
A G+++LV+ LLA A + T G TAL+ A ++ H ++A +L
Sbjct: 571 AAQEGHLELVKYLLAAGA-NVHATTATGDTALTYACEN-GHTDVADVL 616
Score = 51.6 bits (122), Expect = 4e-06
Identities = 84/365 (23%), Positives = 148/365 (40%), Gaps = 32/365 (8%)
Query: 637 PSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEA- 695
PS+S S G GG G G GG + +SEE +D E++S+ E+
Sbjct: 83 PSSSESSSDSDNSGGGGGGGGGG-------GGGGGTSSNNSEEEEDDDDEEEEVSEVESF 135
Query: 696 ---EKKCDGPDHKHVKDAHLTCEA-GQGI------PEGTCHAAQESGPGEEVPHSKAERY 745
+ + P + L+ A G + + A E+ ++ + + +
Sbjct: 136 ILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAF 195
Query: 746 KPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEV 805
E ++S L E ++ +S Q R + S V A +
Sbjct: 196 ADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLI 255
Query: 806 QPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMIT 865
+ S VN G + L + S + + ++LL NV+ + G IT
Sbjct: 256 EGRS-------VNEHTEEGESLLCLACSAGYYELAQVLLAMHA-NVEDRGIKGD----IT 303
Query: 866 PLASAETNEDMAVVWKLL-REGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNL 924
PL +A + +V LL + +VN Q++ G TAL + D+V+ LL A +
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGN-TALTYACAGGYVDVVKVLLESGASIED 362
Query: 925 QDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLR 984
+ +G + LM A G+V++ RLLL + A ++ +++ +AL++A + LL
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 985 AHAEQ 989
A A+Q
Sbjct: 423 AGADQ 427
Score = 48.9 bits (115), Expect = 2e-05
Identities = 39/123 (31%), Positives = 56/123 (45%), Gaps = 3/123 (2%)
Query: 865 TPLASAETNEDMAVVWKLLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVN 923
TPL A + +V LL G N+ AT G TAL + D+ LL AD+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAG-ANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 924 LQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
+ G + LM A G+V V+ L++ A + T T LS+A + H+ + LL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC-AGGHLAVVELL 683
Query: 984 RAH 986
AH
Sbjct: 684 LAH 686
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/149 (32%), Positives = 66/149 (44%), Gaps = 8/149 (5%)
Query: 825 NTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLR 884
+T L + + +VK LL G N TA T L A N V LL+
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGA------NVHATTATGDTALTYACENGHTDVADVLLQ 618
Query: 885 EGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVN-LQDHDGSSALMVACHHGNVD 943
G ++GG+T LM VQ L+S A+VN ++ + L +AC G++
Sbjct: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA 678
Query: 944 LVRLLLAHPACDSSLTDKAGRTALSIALK 972
+V LLLAH A D + K G T L A K
Sbjct: 679 VVELLLAHGA-DPTHRLKDGSTMLIEAAK 706
Score = 43.9 bits (102), Expect = 8e-04
Identities = 51/209 (24%), Positives = 90/209 (43%), Gaps = 36/209 (17%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMI---------------- 864
+ N +TAL + + + +V+ LLE G +++H++K G+T +++
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGA-SIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
Query: 865 -------------TPLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDM 911
TPL+ A + VV LL G T L L S ++
Sbjct: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNI 1198
Query: 912 VQALLSCQADVNLQDHD--GSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSI 969
++ LL+ A++N + G S LM+A +G+ V+LLL + ++ + TAL++
Sbjct: 1199 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL 1258
Query: 970 ALKSPTHMEIAGLL---RAHAEQGRSLGL 995
A E+ LL +A+ E GL
Sbjct: 1259 AC-FQGRTEVVSLLLDRKANVEHRAKTGL 1286
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/99 (30%), Positives = 51/99 (51%), Gaps = 1/99 (1%)
Query: 887 NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVR 946
+++ Q TAL L + E++VQ LL A + +D G + L++A G+V +V
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
Query: 947 LLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRA 985
+LL + A + +++ T LS+A S E+ LL A
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLAC-SGGRQEVVELLLA 1171
Score = 42.0 bits (97), Expect = 0.003
Identities = 55/205 (26%), Positives = 84/205 (40%), Gaps = 49/205 (23%)
Query: 787 VSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLA-------DHNGNTALHYSVSHSNFSI 839
++SR S + L + H+ +KLL+++ + N NTAL + +
Sbjct: 1209 INSRTGSKLGISPLMLAAMNGHTAA-VKLLLDMGSDINAQIETNRNTALTLACFQGRTEV 1267
Query: 840 VKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG-NVN--------- 889
V LLL+ NV+H+ K G +TPL A + V LL +G +VN
Sbjct: 1268 VSLLLDRKA-NVEHRAKTG-----LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1321
Query: 890 ----IQATQG---------------------GQTALMLGVSHDREDMVQALLSCQADVNL 924
I A +G G T L L + D+VQ L+ ADV+
Sbjct: 1322 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1381
Query: 925 QDHDGSSALMVACHHGNVDLVRLLL 949
D+ + LM A G+V +VR L+
Sbjct: 1382 ADNRKITPLMAAFRKGHVKVVRYLV 1406
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 67.4 bits (163), Expect = 6e-11
Identities = 59/178 (33%), Positives = 90/178 (50%), Gaps = 12/178 (6%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN GNTAL Y+ + +VK+LLE+G DH N+ G+T PL A + +
Sbjct: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH-NENGHT-----PLMEAGSAGHV 380
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
V LL G +N + + ++AL L +MV+ LL AD + + +ALM
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSL 993
AC G+V++ RLLL A ++ + + L++A H+E+A LL E+G SL
Sbjct: 441 ACMDGHVEVARLLLDSGA-QVNMPADSFESPLTLA-ACGGHVELAALL---IERGASL 493
Score = 52.8 bits (125), Expect = 2e-06
Identities = 50/168 (29%), Positives = 85/168 (50%), Gaps = 12/168 (7%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN+ + + L + + + LL+E G +++ N GYT +M A+ E +E+M
Sbjct: 460 VNMPADSFESPLTLAACGGHVELAALLIERGA-SLEEVNDEGYTPLME---AAREGHEEM 515
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+ LL +G N+N Q + +TAL L ++ L+ AD+ L S+ LM
Sbjct: 516 VAL--LLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLME 570
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
A G+++LV+ LLA A + T G TAL+ A ++ H ++A +L
Sbjct: 571 AAQEGHLELVKYLLAAGA-NVHATTATGDTALTYACEN-GHTDVADVL 616
Score = 51.6 bits (122), Expect = 4e-06
Identities = 84/365 (23%), Positives = 148/365 (40%), Gaps = 32/365 (8%)
Query: 637 PSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEA- 695
PS+S S G GG G G GG + +SEE +D E++S+ E+
Sbjct: 83 PSSSESSSDSDNSGGGGGGGGGG-------GGGGGTSSNNSEEEEDDDDEEEEVSEVESF 135
Query: 696 ---EKKCDGPDHKHVKDAHLTCEA-GQGI------PEGTCHAAQESGPGEEVPHSKAERY 745
+ + P + L+ A G + + A E+ ++ + + +
Sbjct: 136 ILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAF 195
Query: 746 KPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEV 805
E ++S L E ++ +S Q R + S V A +
Sbjct: 196 ADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLI 255
Query: 806 QPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMIT 865
+ S VN G + L + S + + ++LL NV+ + G IT
Sbjct: 256 EGRS-------VNEHTEEGESLLCLACSAGYYELAQVLLAMHA-NVEDRGIKGD----IT 303
Query: 866 PLASAETNEDMAVVWKLL-REGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNL 924
PL +A + +V LL + +VN Q++ G TAL + D+V+ LL A +
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGN-TALTYACAGGYVDVVKVLLESGASIED 362
Query: 925 QDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLR 984
+ +G + LM A G+V++ RLLL + A ++ +++ +AL++A + LL
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 985 AHAEQ 989
A A+Q
Sbjct: 423 AGADQ 427
Score = 48.9 bits (115), Expect = 2e-05
Identities = 39/123 (31%), Positives = 56/123 (45%), Gaps = 3/123 (2%)
Query: 865 TPLASAETNEDMAVVWKLLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVN 923
TPL A + +V LL G N+ AT G TAL + D+ LL AD+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAG-ANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 924 LQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
+ G + LM A G+V V+ L++ A + T T LS+A + H+ + LL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC-AGGHLAVVELL 683
Query: 984 RAH 986
AH
Sbjct: 684 LAH 686
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/149 (32%), Positives = 66/149 (44%), Gaps = 8/149 (5%)
Query: 825 NTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLR 884
+T L + + +VK LL G N TA T L A N V LL+
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGA------NVHATTATGDTALTYACENGHTDVADVLLQ 618
Query: 885 EGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVN-LQDHDGSSALMVACHHGNVD 943
G ++GG+T LM VQ L+S A+VN ++ + L +AC G++
Sbjct: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA 678
Query: 944 LVRLLLAHPACDSSLTDKAGRTALSIALK 972
+V LLLAH A D + K G T L A K
Sbjct: 679 VVELLLAHGA-DPTHRLKDGSTMLIEAAK 706
Score = 43.9 bits (102), Expect = 8e-04
Identities = 51/209 (24%), Positives = 90/209 (43%), Gaps = 36/209 (17%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMI---------------- 864
+ N +TAL + + + +V+ LLE G +++H++K G+T +++
Sbjct: 829 ESNHDTALTLACAGGHEELVQTLLERGA-SIEHRDKKGFTPLILAATAGHVGVVEILLDN 887
Query: 865 -------------TPLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDM 911
TPL+ A + VV LL G T L L S ++
Sbjct: 888 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNI 947
Query: 912 VQALLSCQADVNLQDHD--GSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSI 969
++ LL+ A++N + G S LM+A +G+ V+LLL + ++ + TAL++
Sbjct: 948 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL 1007
Query: 970 ALKSPTHMEIAGLL---RAHAEQGRSLGL 995
A E+ LL +A+ E GL
Sbjct: 1008 AC-FQGRTEVVSLLLDRKANVEHRAKTGL 1035
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/99 (30%), Positives = 51/99 (51%), Gaps = 1/99 (1%)
Query: 887 NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVR 946
+++ Q TAL L + E++VQ LL A + +D G + L++A G+V +V
Sbjct: 823 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
Query: 947 LLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRA 985
+LL + A + +++ T LS+A S E+ LL A
Sbjct: 883 ILLDNGADIEAQSERTKDTPLSLAC-SGGRQEVVELLLA 920
Score = 42.0 bits (97), Expect = 0.003
Identities = 55/205 (26%), Positives = 84/205 (40%), Gaps = 49/205 (23%)
Query: 787 VSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLA-------DHNGNTALHYSVSHSNFSI 839
++SR S + L + H+ +KLL+++ + N NTAL + +
Sbjct: 958 INSRTGSKLGISPLMLAAMNGHTAA-VKLLLDMGSDINAQIETNRNTALTLACFQGRTEV 1016
Query: 840 VKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG-NVN--------- 889
V LLL+ NV+H+ K G +TPL A + V LL +G +VN
Sbjct: 1017 VSLLLDRKA-NVEHRAKTG-----LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1070
Query: 890 ----IQATQG---------------------GQTALMLGVSHDREDMVQALLSCQADVNL 924
I A +G G T L L + D+VQ L+ ADV+
Sbjct: 1071 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1130
Query: 925 QDHDGSSALMVACHHGNVDLVRLLL 949
D+ + LM A G+V +VR L+
Sbjct: 1131 ADNRKITPLMAAFRKGHVKVVRYLV 1155
>gi|7657265 fem-1 homolog b [Homo sapiens]
Length = 627
Score = 66.2 bits (160), Expect = 1e-10
Identities = 56/170 (32%), Positives = 88/170 (51%), Gaps = 11/170 (6%)
Query: 823 NGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKL 882
+G TAL + +F +VKLL+ G NV+H T TPL +A + + +V K
Sbjct: 87 DGATALWCAAGAGHFEVVKLLVSHGA-NVNHT-----TVTNSTPLRAACFDGRLDIV-KY 139
Query: 883 LREGNVNIQ-ATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGN 941
L E N NI A + T LM+ D+V+ LL +AD N + H G++AL A G+
Sbjct: 140 LVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGH 199
Query: 942 VDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGR 991
+D+V+ L+ A + + + G T L +A +S ++ LL +HA+ R
Sbjct: 200 IDIVKELIKWRA--AIVVNGHGMTPLKVAAES-CKADVVELLLSHADCDR 246
Score = 44.7 bits (104), Expect = 4e-04
Identities = 48/164 (29%), Positives = 74/164 (45%), Gaps = 17/164 (10%)
Query: 825 NTALHYSVSHSNFSIVKLLLE--------TGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
+T L + + + +V+LLLE TG D GY T L A
Sbjct: 47 STPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFD-----GYVIDGATALWCAAGAGHF 101
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
VV L+ G NVN T T L R D+V+ L+ A++++ + ++ LM+
Sbjct: 102 EVVKLLVSHGANVN-HTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMI 160
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEI 979
A + G+ D+VR LL A D + G TAL A ++ H++I
Sbjct: 161 AAYKGHTDVVRYLLEQRA-DPNAKAHCGATALHFAAEA-GHIDI 202
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 64.7 bits (156), Expect = 4e-10
Identities = 57/178 (32%), Positives = 90/178 (50%), Gaps = 10/178 (5%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VNL D +GNTAL + + IV+ LL+ G V+ +++G T L A +
Sbjct: 229 VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY-VNIPDRSGDTV-----LIGAVRGGHV 282
Query: 877 AVVWKLLRE-GNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+V LL++ +++I+ Q +TAL V MV+ +L C D + DG + L+
Sbjct: 283 EIVRALLQKYADIDIRG-QDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIK 341
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSL 993
A N+++V LLL A S DK G T L IA++ + ++A LL + + GR L
Sbjct: 342 ATKMRNIEVVELLLDKGA-KVSAVDKKGDTPLHIAIRGRSR-KLAELLLRNPKDGRLL 397
Score = 57.0 bits (136), Expect = 9e-08
Identities = 42/124 (33%), Positives = 65/124 (52%), Gaps = 10/124 (8%)
Query: 832 VSHSNFSIVKLLLETGVC-NVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG-NVN 889
V N +K LLE C +VD +N+ G T +MI A ++ +V +L++ G N N
Sbjct: 13 VEEENIPALKALLEK--CKDVDERNECGQTPLMI-----AAEQGNLEIVKELIKNGANCN 65
Query: 890 IQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLL 949
++ TAL+ +V+ LL C ++ +D G +ALM AC+ G D+V LLL
Sbjct: 66 LEDLDNW-TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 124
Query: 950 AHPA 953
+H A
Sbjct: 125 SHGA 128
Score = 53.5 bits (127), Expect = 1e-06
Identities = 49/160 (30%), Positives = 78/160 (48%), Gaps = 9/160 (5%)
Query: 830 YSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVN 889
++ + IV LLL+ G V+ +K G TPL A + V LL G
Sbjct: 143 WAAGRGHADIVHLLLQNGA-KVNCSDKYG-----TTPLVWAARKGHLECVKHLLAMGADV 196
Query: 890 IQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLL 949
Q TAL++ V V+ +L +VNL D DG++ALM+A G+ ++V+ LL
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
Query: 950 AHPACDSSLTDKAGRTALSIALKSPTHMEIA-GLLRAHAE 988
++ D++G T L A++ H+EI LL+ +A+
Sbjct: 257 -DAGTYVNIPDRSGDTVLIGAVRG-GHVEIVRALLQKYAD 294
Score = 52.4 bits (124), Expect = 2e-06
Identities = 53/162 (32%), Positives = 80/162 (49%), Gaps = 10/162 (6%)
Query: 823 NGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKL 882
N TAL +V VK +L+ NV+ +K G TA+MI AS E + + +V L
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKRNP-NVNLTDKDGNTALMI---ASKEGHTE--IVQDL 255
Query: 883 LREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNV 942
L G + G T L+ V ++V+ALL AD++++ D +AL A GN
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
Query: 943 DLVR-LLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
+VR +L +P D+ + K G T L A K ++E+ LL
Sbjct: 316 TMVRDILQCNP--DTEICTKDGETPLIKATKM-RNIEVVELL 354
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/157 (31%), Positives = 76/157 (48%), Gaps = 12/157 (7%)
Query: 824 GNTALHYSVSHSNFSIVKLLLETGV-CNVDHQNKAGYTAVMITPLASAETNEDMAVVWKL 882
G T L + N IVK L++ G CN++ + T L SA + +V +L
Sbjct: 38 GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW-------TALISASKEGHVHIVEEL 90
Query: 883 LREGNVNIQ-ATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGN 941
L+ G VN++ GG TALM R D+V+ LLS A+ ++ ++ A G+
Sbjct: 91 LKCG-VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGH 149
Query: 942 VDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHME 978
D+V LLL + A + +DK G T L A + H+E
Sbjct: 150 ADIVHLLLQNGA-KVNCSDKYGTTPLVWAARK-GHLE 184
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 64.7 bits (156), Expect = 4e-10
Identities = 58/178 (32%), Positives = 89/178 (50%), Gaps = 12/178 (6%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN GNTAL Y+ + IVK+LL G N++ N+ G+T PL A + +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGA-NIEDHNENGHT-----PLMEAASAGHV 351
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
V LL G +N + + ++AL L DMV+ LL AD + + +ALM
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSL 993
AC G+V++ RLLL A ++ + + L++A H+E+A LL E+G +L
Sbjct: 412 ACMDGHVEVARLLLDSGA-QVNMPADSFESPLTLA-ACGGHVELAALL---IERGANL 464
Score = 56.2 bits (134), Expect = 1e-07
Identities = 51/168 (30%), Positives = 85/168 (50%), Gaps = 12/168 (7%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN+ + + L + + + LL+E G N++ N GYT +M A+ E +E+M
Sbjct: 431 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLME---AAREGHEEM 486
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+ LL +G N+N Q + +TAL L ++ L+ AD+ L S+ LM
Sbjct: 487 VAL--LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLME 541
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
A G+++LV+ LLA A + T G TAL+ A ++ H ++A +L
Sbjct: 542 ASQEGHLELVKYLLASGA-NVHATTATGDTALTYACEN-GHTDVADVL 587
Score = 53.1 bits (126), Expect = 1e-06
Identities = 49/174 (28%), Positives = 85/174 (48%), Gaps = 7/174 (4%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN G + L + S + + ++LL D NK ITPL +A + +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD-----ITPLMAASSGGYL 285
Query: 877 AVV-WKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+V LL + +VN Q+ G TAL + D+V+ LL+ A++ + +G + LM
Sbjct: 286 DIVKLLLLHDADVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQ 989
A G+V++ R+LL H A ++ +++ +AL++A + LL A A+Q
Sbjct: 345 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398
Score = 50.1 bits (118), Expect = 1e-05
Identities = 50/160 (31%), Positives = 80/160 (50%), Gaps = 7/160 (4%)
Query: 827 ALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG 886
+L + S + + V+ LL+ G +V+ + G + + LA + ++A V L
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGR-SVNEHTEEGESLLC---LACSAGYYELAQVL-LAMHA 262
Query: 887 NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVR 946
NV + +G T LM S D+V+ LL ADVN Q G++AL AC G VD+V+
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 947 LLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
+LL + + ++ G T L A S H+E+A +L H
Sbjct: 323 VLL-NEGANIEDHNENGHTPLMEA-ASAGHVEVARVLLDH 360
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 76/167 (45%), Gaps = 19/167 (11%)
Query: 805 VQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMI 864
+ HS F + + LA + G+ +V+ LLE G D ++K T M
Sbjct: 364 INTHSNEFKESALTLACYKGH-----------LDMVRFLLEAGA---DQEHK---TDEMH 406
Query: 865 TPLASAETNEDMAVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVN 923
T L A + + V LL G VN+ A ++ L L ++ L+ A++
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPA-DSFESPLTLAACGGHVELAALLIERGANLE 465
Query: 924 LQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
+ +G + LM A G+ ++V LLLA A ++ T++ TAL++A
Sbjct: 466 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Score = 30.4 bits (67), Expect = 8.6
Identities = 21/63 (33%), Positives = 29/63 (46%), Gaps = 2/63 (3%)
Query: 865 TPLASAETNEDMAVVWKLLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVN 923
TPL A + +V LL G N+ AT G TAL + D+ LL AD++
Sbjct: 537 TPLMEASQEGHLELVKYLLASG-ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Query: 924 LQD 926
Q+
Sbjct: 596 KQE 598
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 64.7 bits (156), Expect = 4e-10
Identities = 58/178 (32%), Positives = 89/178 (50%), Gaps = 12/178 (6%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN GNTAL Y+ + IVK+LL G N++ N+ G+T PL A + +
Sbjct: 287 VNSQSATGNTALTYACAGGFVDIVKVLLNEGA-NIEDHNENGHT-----PLMEAASAGHV 340
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
V LL G +N + + ++AL L DMV+ LL AD + + +ALM
Sbjct: 341 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSL 993
AC G+V++ RLLL A ++ + + L++A H+E+A LL E+G +L
Sbjct: 401 ACMDGHVEVARLLLDSGA-QVNMPADSFESPLTLA-ACGGHVELAALL---IERGANL 453
Score = 56.2 bits (134), Expect = 1e-07
Identities = 51/168 (30%), Positives = 85/168 (50%), Gaps = 12/168 (7%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN+ + + L + + + LL+E G N++ N GYT +M A+ E +E+M
Sbjct: 420 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLME---AAREGHEEM 475
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+ LL +G N+N Q + +TAL L ++ L+ AD+ L S+ LM
Sbjct: 476 VAL--LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLME 530
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
A G+++LV+ LLA A + T G TAL+ A ++ H ++A +L
Sbjct: 531 ASQEGHLELVKYLLASGA-NVHATTATGDTALTYACEN-GHTDVADVL 576
Score = 53.1 bits (126), Expect = 1e-06
Identities = 49/174 (28%), Positives = 85/174 (48%), Gaps = 7/174 (4%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN G + L + S + + ++LL D NK ITPL +A + +
Sbjct: 220 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD-----ITPLMAASSGGYL 274
Query: 877 AVV-WKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+V LL + +VN Q+ G TAL + D+V+ LL+ A++ + +G + LM
Sbjct: 275 DIVKLLLLHDADVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 333
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQ 989
A G+V++ R+LL H A ++ +++ +AL++A + LL A A+Q
Sbjct: 334 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 387
Score = 52.0 bits (123), Expect = 3e-06
Identities = 62/224 (27%), Positives = 102/224 (45%), Gaps = 14/224 (6%)
Query: 763 PETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADH 822
PET + LL + + R++S S + A+ L ++ + H A
Sbjct: 140 PETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHN-------AGQ 192
Query: 823 NGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKL 882
+L + S + + V+ LL+ G +V+ + G + + LA + ++A V L
Sbjct: 193 VDTRSLAEACSDGDVNAVRKLLDEGR-SVNEHTEEGESLLC---LACSAGYYELAQVL-L 247
Query: 883 LREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNV 942
NV + +G T LM S D+V+ LL ADVN Q G++AL AC G V
Sbjct: 248 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 307
Query: 943 DLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
D+V++LL + + ++ G T L A S H+E+A +L H
Sbjct: 308 DIVKVLL-NEGANIEDHNENGHTPLMEA-ASAGHVEVARVLLDH 349
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 76/167 (45%), Gaps = 19/167 (11%)
Query: 805 VQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMI 864
+ HS F + + LA + G+ +V+ LLE G D ++K T M
Sbjct: 353 INTHSNEFKESALTLACYKGH-----------LDMVRFLLEAGA---DQEHK---TDEMH 395
Query: 865 TPLASAETNEDMAVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVN 923
T L A + + V LL G VN+ A ++ L L ++ L+ A++
Sbjct: 396 TALMEACMDGHVEVARLLLDSGAQVNMPA-DSFESPLTLAACGGHVELAALLIERGANLE 454
Query: 924 LQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
+ +G + LM A G+ ++V LLLA A ++ T++ TAL++A
Sbjct: 455 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
Score = 30.4 bits (67), Expect = 8.6
Identities = 21/63 (33%), Positives = 29/63 (46%), Gaps = 2/63 (3%)
Query: 865 TPLASAETNEDMAVVWKLLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVN 923
TPL A + +V LL G N+ AT G TAL + D+ LL AD++
Sbjct: 526 TPLMEASQEGHLELVKYLLASG-ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Query: 924 LQD 926
Q+
Sbjct: 585 KQE 587
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 64.7 bits (156), Expect = 4e-10
Identities = 58/178 (32%), Positives = 89/178 (50%), Gaps = 12/178 (6%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN GNTAL Y+ + IVK+LL G N++ N+ G+T PL A + +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGA-NIEDHNENGHT-----PLMEAASAGHV 351
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
V LL G +N + + ++AL L DMV+ LL AD + + +ALM
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSL 993
AC G+V++ RLLL A ++ + + L++A H+E+A LL E+G +L
Sbjct: 412 ACMDGHVEVARLLLDSGA-QVNMPADSFESPLTLA-ACGGHVELAALL---IERGANL 464
Score = 56.2 bits (134), Expect = 1e-07
Identities = 51/168 (30%), Positives = 85/168 (50%), Gaps = 12/168 (7%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN+ + + L + + + LL+E G N++ N GYT +M A+ E +E+M
Sbjct: 431 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLME---AAREGHEEM 486
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+ LL +G N+N Q + +TAL L ++ L+ AD+ L S+ LM
Sbjct: 487 VAL--LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLME 541
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
A G+++LV+ LLA A + T G TAL+ A ++ H ++A +L
Sbjct: 542 ASQEGHLELVKYLLASGA-NVHATTATGDTALTYACEN-GHTDVADVL 587
Score = 53.1 bits (126), Expect = 1e-06
Identities = 49/174 (28%), Positives = 85/174 (48%), Gaps = 7/174 (4%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN G + L + S + + ++LL D NK ITPL +A + +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD-----ITPLMAASSGGYL 285
Query: 877 AVV-WKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+V LL + +VN Q+ G TAL + D+V+ LL+ A++ + +G + LM
Sbjct: 286 DIVKLLLLHDADVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQ 989
A G+V++ R+LL H A ++ +++ +AL++A + LL A A+Q
Sbjct: 345 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398
Score = 50.1 bits (118), Expect = 1e-05
Identities = 50/160 (31%), Positives = 80/160 (50%), Gaps = 7/160 (4%)
Query: 827 ALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG 886
+L + S + + V+ LL+ G +V+ + G + + LA + ++A V L
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGR-SVNEHTEEGESLLC---LACSAGYYELAQVL-LAMHA 262
Query: 887 NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVR 946
NV + +G T LM S D+V+ LL ADVN Q G++AL AC G VD+V+
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 947 LLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
+LL + + ++ G T L A S H+E+A +L H
Sbjct: 323 VLL-NEGANIEDHNENGHTPLMEA-ASAGHVEVARVLLDH 360
Score = 47.4 bits (111), Expect = 7e-05
Identities = 37/123 (30%), Positives = 56/123 (45%), Gaps = 3/123 (2%)
Query: 865 TPLASAETNEDMAVVWKLLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVN 923
TPL A + +V LL G N+ AT G TAL + D+ LL AD+
Sbjct: 537 TPLMEASQEGHLELVKYLLASG-ANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 595
Query: 924 LQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
+ G + LM A G++ V+ L++ A + T T +S+A + H+ + LL
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC-AGGHLAVVELL 654
Query: 984 RAH 986
AH
Sbjct: 655 LAH 657
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/149 (31%), Positives = 67/149 (44%), Gaps = 8/149 (5%)
Query: 825 NTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLR 884
+T L + + +VK LL +G N TA T L A N V LL+
Sbjct: 536 STPLMEASQEGHLELVKYLLASGA------NVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 885 EGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVN-LQDHDGSSALMVACHHGNVD 943
G ++GG+T LM VQ L+S A+VN ++ + + +AC G++
Sbjct: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLA 649
Query: 944 LVRLLLAHPACDSSLTDKAGRTALSIALK 972
+V LLLAH A D + K G T L A K
Sbjct: 650 VVELLLAHGA-DPTHRLKDGSTMLIEAAK 677
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 76/167 (45%), Gaps = 19/167 (11%)
Query: 805 VQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMI 864
+ HS F + + LA + G+ +V+ LLE G D ++K T M
Sbjct: 364 INTHSNEFKESALTLACYKGH-----------LDMVRFLLEAGA---DQEHK---TDEMH 406
Query: 865 TPLASAETNEDMAVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVN 923
T L A + + V LL G VN+ A ++ L L ++ L+ A++
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPA-DSFESPLTLAACGGHVELAALLIERGANLE 465
Query: 924 LQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
+ +G + LM A G+ ++V LLLA A ++ T++ TAL++A
Sbjct: 466 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/180 (26%), Positives = 83/180 (46%), Gaps = 11/180 (6%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVW 880
D G T L + + + +V++LL+ G +++ Q++ TPL+ A + VV
Sbjct: 1085 DKKGFTPLILAATAGHVGVVEILLDKGG-DIEAQSER----TKDTPLSLACSGGRQEVVD 1139
Query: 881 KLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHD--GSSALMVACH 938
LL G T L L S ++++ LL+ A++N + G S LM+A
Sbjct: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
Query: 939 HGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL---RAHAEQGRSLGL 995
+G+V V+LLL + ++ + TAL++A E+ LL +A+ E GL
Sbjct: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALTLAC-FQGRAEVVSLLLDRKANVEHRAKTGL 1258
Score = 40.8 bits (94), Expect = 0.006
Identities = 55/205 (26%), Positives = 84/205 (40%), Gaps = 49/205 (23%)
Query: 787 VSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLA-------DHNGNTALHYSVSHSNFSI 839
++SR S + L + H P +KLL+++ + N NTAL + +
Sbjct: 1181 INSRTGSKLGISPLMLAAMNGHVPA-VKLLLDMGSDINAQIETNRNTALTLACFQGRAEV 1239
Query: 840 VKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG-NVN--------- 889
V LLL+ NV+H+ K G +TPL A + V LL +G +VN
Sbjct: 1240 VSLLLDRKA-NVEHRAKTG-----LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 890 ----IQATQG---------------------GQTALMLGVSHDREDMVQALLSCQADVNL 924
I A +G G T L L + D+VQ L+ ADV+
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 925 QDHDGSSALMVACHHGNVDLVRLLL 949
D+ + LM A G+V +V+ L+
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 32.7 bits (73), Expect = 1.7
Identities = 38/190 (20%), Positives = 86/190 (45%), Gaps = 24/190 (12%)
Query: 340 GSISSLKQQVSALEGE-------LSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVA 392
G ++ L Q++SA+E + G ++ + +EE+++ +++ ++EL+
Sbjct: 784 GKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVER 843
Query: 393 QLEGQFHQENAK---DTQGQTDVMVNTDPVHGLLTRESCDKGI--EVNLLGSMESESWGH 447
QL+ + Q+ K +T+GQ D + L ++ +G+ E GS+ + +
Sbjct: 844 QLQMKTQQQFTKEYLETKGQKDTV--------SLHQQCSHRGVFPEGEGDGSLPEDHFSE 895
Query: 448 RGEENGLLWGPDGHKQGNQSP--AERVLLPQLSLPQGPEQVLTSSVHSFLSTELRIEEAG 505
+ + +L+ + QSP AE++ + P+ +S + S + L +++
Sbjct: 896 LPQVDTILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVS 955
Query: 506 TEQE--GGPQ 513
Q+ G PQ
Sbjct: 956 GNQQIVGQPQ 965
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 64.7 bits (156), Expect = 4e-10
Identities = 58/178 (32%), Positives = 89/178 (50%), Gaps = 12/178 (6%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN GNTAL Y+ + IVK+LL G N++ N+ G+T PL A + +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGA-NIEDHNENGHT-----PLMEAASAGHV 351
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
V LL G +N + + ++AL L DMV+ LL AD + + +ALM
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSL 993
AC G+V++ RLLL A ++ + + L++A H+E+A LL E+G +L
Sbjct: 412 ACMDGHVEVARLLLDSGA-QVNMPADSFESPLTLA-ACGGHVELAALL---IERGANL 464
Score = 56.2 bits (134), Expect = 1e-07
Identities = 51/168 (30%), Positives = 85/168 (50%), Gaps = 12/168 (7%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN+ + + L + + + LL+E G N++ N GYT +M A+ E +E+M
Sbjct: 431 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLME---AAREGHEEM 486
Query: 877 AVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+ LL +G N+N Q + +TAL L ++ L+ AD+ L S+ LM
Sbjct: 487 VAL--LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLME 541
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
A G+++LV+ LLA A + T G TAL+ A ++ H ++A +L
Sbjct: 542 ASQEGHLELVKYLLASGA-NVHATTATGDTALTYACEN-GHTDVADVL 587
Score = 53.1 bits (126), Expect = 1e-06
Identities = 49/174 (28%), Positives = 85/174 (48%), Gaps = 7/174 (4%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
VN G + L + S + + ++LL D NK ITPL +A + +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD-----ITPLMAASSGGYL 285
Query: 877 AVV-WKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMV 935
+V LL + +VN Q+ G TAL + D+V+ LL+ A++ + +G + LM
Sbjct: 286 DIVKLLLLHDADVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
Query: 936 ACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQ 989
A G+V++ R+LL H A ++ +++ +AL++A + LL A A+Q
Sbjct: 345 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398
Score = 50.1 bits (118), Expect = 1e-05
Identities = 50/160 (31%), Positives = 80/160 (50%), Gaps = 7/160 (4%)
Query: 827 ALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG 886
+L + S + + V+ LL+ G +V+ + G + + LA + ++A V L
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGR-SVNEHTEEGESLLC---LACSAGYYELAQVL-LAMHA 262
Query: 887 NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVR 946
NV + +G T LM S D+V+ LL ADVN Q G++AL AC G VD+V+
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 947 LLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
+LL + + ++ G T L A S H+E+A +L H
Sbjct: 323 VLL-NEGANIEDHNENGHTPLMEA-ASAGHVEVARVLLDH 360
Score = 47.4 bits (111), Expect = 7e-05
Identities = 37/123 (30%), Positives = 56/123 (45%), Gaps = 3/123 (2%)
Query: 865 TPLASAETNEDMAVVWKLLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVN 923
TPL A + +V LL G N+ AT G TAL + D+ LL AD+
Sbjct: 537 TPLMEASQEGHLELVKYLLASG-ANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 595
Query: 924 LQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
+ G + LM A G++ V+ L++ A + T T +S+A + H+ + LL
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC-AGGHLAVVELL 654
Query: 984 RAH 986
AH
Sbjct: 655 LAH 657
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/149 (31%), Positives = 67/149 (44%), Gaps = 8/149 (5%)
Query: 825 NTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLR 884
+T L + + +VK LL +G N TA T L A N V LL+
Sbjct: 536 STPLMEASQEGHLELVKYLLASGA------NVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 885 EGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVN-LQDHDGSSALMVACHHGNVD 943
G ++GG+T LM VQ L+S A+VN ++ + + +AC G++
Sbjct: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLA 649
Query: 944 LVRLLLAHPACDSSLTDKAGRTALSIALK 972
+V LLLAH A D + K G T L A K
Sbjct: 650 VVELLLAHGA-DPTHRLKDGSTMLIEAAK 677
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 76/167 (45%), Gaps = 19/167 (11%)
Query: 805 VQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMI 864
+ HS F + + LA + G+ +V+ LLE G D ++K T M
Sbjct: 364 INTHSNEFKESALTLACYKGH-----------LDMVRFLLEAGA---DQEHK---TDEMH 406
Query: 865 TPLASAETNEDMAVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVN 923
T L A + + V LL G VN+ A ++ L L ++ L+ A++
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPA-DSFESPLTLAACGGHVELAALLIERGANLE 465
Query: 924 LQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
+ +G + LM A G+ ++V LLLA A ++ T++ TAL++A
Sbjct: 466 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/180 (26%), Positives = 83/180 (46%), Gaps = 11/180 (6%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVW 880
D G T L + + + +V++LL+ G +++ Q++ TPL+ A + VV
Sbjct: 1085 DKKGFTPLILAATAGHVGVVEILLDKGG-DIEAQSER----TKDTPLSLACSGGRQEVVD 1139
Query: 881 KLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHD--GSSALMVACH 938
LL G T L L S ++++ LL+ A++N + G S LM+A
Sbjct: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
Query: 939 HGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL---RAHAEQGRSLGL 995
+G+V V+LLL + ++ + TAL++A E+ LL +A+ E GL
Sbjct: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALTLAC-FQGRAEVVSLLLDRKANVEHRAKTGL 1258
Score = 40.8 bits (94), Expect = 0.006
Identities = 55/205 (26%), Positives = 84/205 (40%), Gaps = 49/205 (23%)
Query: 787 VSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLA-------DHNGNTALHYSVSHSNFSI 839
++SR S + L + H P +KLL+++ + N NTAL + +
Sbjct: 1181 INSRTGSKLGISPLMLAAMNGHVPA-VKLLLDMGSDINAQIETNRNTALTLACFQGRAEV 1239
Query: 840 VKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG-NVN--------- 889
V LLL+ NV+H+ K G +TPL A + V LL +G +VN
Sbjct: 1240 VSLLLDRKA-NVEHRAKTG-----LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 890 ----IQATQG---------------------GQTALMLGVSHDREDMVQALLSCQADVNL 924
I A +G G T L L + D+VQ L+ ADV+
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 925 QDHDGSSALMVACHHGNVDLVRLLL 949
D+ + LM A G+V +V+ L+
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 32.7 bits (73), Expect = 1.7
Identities = 38/190 (20%), Positives = 86/190 (45%), Gaps = 24/190 (12%)
Query: 340 GSISSLKQQVSALEGE-------LSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVA 392
G ++ L Q++SA+E + G ++ + +EE+++ +++ ++EL+
Sbjct: 784 GKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVER 843
Query: 393 QLEGQFHQENAK---DTQGQTDVMVNTDPVHGLLTRESCDKGI--EVNLLGSMESESWGH 447
QL+ + Q+ K +T+GQ D + L ++ +G+ E GS+ + +
Sbjct: 844 QLQMKTQQQFTKEYLETKGQKDTV--------SLHQQCSHRGVFPEGEGDGSLPEDHFSE 895
Query: 448 RGEENGLLWGPDGHKQGNQSP--AERVLLPQLSLPQGPEQVLTSSVHSFLSTELRIEEAG 505
+ + +L+ + QSP AE++ + P+ +S + S + L +++
Sbjct: 896 LPQVDTILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVS 955
Query: 506 TEQE--GGPQ 513
Q+ G PQ
Sbjct: 956 GNQQIVGQPQ 965
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 64.7 bits (156), Expect = 4e-10
Identities = 55/198 (27%), Positives = 87/198 (43%), Gaps = 39/198 (19%)
Query: 818 NLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMA 877
N+ D GNTALH + + ++++ L++ G+ +++ QN G TA L SA
Sbjct: 186 NVKDKEGNTALHLAAGRGHMAVLQRLVDIGL-DLEEQNAEGLTA-----LHSAAGGSHPD 239
Query: 878 VVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVAC 937
V LLR G+ TQ + L ED+ + L+ N+ DH G+S L +A
Sbjct: 240 CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAV 299
Query: 938 HHGNVDLVRLLL----------------AHPAC----------------DSSLTDKAGRT 965
H LVRLL+ H A D +L DK G+T
Sbjct: 300 RHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKT 359
Query: 966 ALSIALKSPTHMEIAGLL 983
AL++A++S H+ + ++
Sbjct: 360 ALAVAVRS-NHVSLVDMI 376
Score = 51.6 bits (122), Expect = 4e-06
Identities = 40/136 (29%), Positives = 63/136 (46%), Gaps = 12/136 (8%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCN--VDHQNKAGYTAVMITPLASAETNE 874
VN + LHY+ + + ++L+ G C VDHQ + PL A +
Sbjct: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGAS--------PLHLAVRHN 302
Query: 875 DMAVVWKLLREGNVNIQATQGGQ-TALMLGVSHDREDMVQALLSCQADVNLQDHDGSSAL 933
A+V +LL + ++ A Q T L L H +D+ LL D+NL+D G +AL
Sbjct: 303 FPALV-RLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTAL 361
Query: 934 MVACHHGNVDLVRLLL 949
VA +V LV +++
Sbjct: 362 AVAVRSNHVSLVDMII 377
Score = 39.7 bits (91), Expect = 0.014
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 9/157 (5%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVM-----ITPLASAETNED 875
+H G ALH++ + V+LLLE VD ++ G + L +
Sbjct: 45 NHVGRVALHWAAGAGHEQAVRLLLEHEAA-VDEEDAVGALTEARLCFGMNALLLSAWFGH 103
Query: 876 MAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHD--GSSAL 933
+ ++ L+ G ++ G T L ++ ++ DV L D G +A
Sbjct: 104 LRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAF 163
Query: 934 MVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
A HG +D + L+ CD ++ DK G TAL +A
Sbjct: 164 HRAAEHGQLDALDFLVGS-GCDHNVKDKEGNTALHLA 199
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 63.9 bits (154), Expect = 7e-10
Identities = 55/178 (30%), Positives = 89/178 (50%), Gaps = 16/178 (8%)
Query: 814 KLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETN 873
K+ VN D +G +ALH++ + N ++ LLLE VD ++ G + PL A
Sbjct: 39 KINVNFQDPDGFSALHHAALNGNTELISLLLEAQAA-VDIKDNKG-----MRPLHYAAWQ 92
Query: 874 EDMAVVWKLLREGN-VNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSA 932
+ +L+ G+ VNI + +G L L H D+ + LL Q++ + D+ G +
Sbjct: 93 GRKEPMKLVLKAGSAVNIPSDEG-HIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTP 151
Query: 933 LMVACHHGNVDLVRLLLAHPACDSSL-------TDKAGRTALSIALKSPTHMEIAGLL 983
L +AC G V +V+LLL+ C + L TD G + L +A K+ H++I LL
Sbjct: 152 LDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKN-GHIDIIRLL 208
Score = 45.1 bits (105), Expect = 3e-04
Identities = 47/169 (27%), Positives = 75/169 (44%), Gaps = 15/169 (8%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
V++ D+ G LHY+ +KL+L+ G V+ + G+ PL A +
Sbjct: 75 VDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA-VNIPSDEGHI-----PLHLAAQHGHY 128
Query: 877 AVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLS---CQADV-----NLQDHD 928
V LL+ + G+T L L R +VQ LLS C A + + D +
Sbjct: 129 DVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPN 188
Query: 929 GSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHM 977
G+S L +A +G++D++RLLL D + K+G AL T +
Sbjct: 189 GTSPLHLAAKNGHIDIIRLLL-QAGIDINRQTKSGTALHEAALCGKTEV 236
Score = 36.6 bits (83), Expect = 0.12
Identities = 39/133 (29%), Positives = 61/133 (45%), Gaps = 23/133 (17%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVW 880
D NG + LH + + + I++LLL+ G+ +++ Q K+G T L A VV
Sbjct: 186 DPNGTSPLHLAAKNGHIDIIRLLLQAGI-DINRQTKSG------TALHEAALCGKTEVVR 238
Query: 881 KLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQD--HDGSSALMVAC 937
LL G N +++ T QTAL D+V + QA ++ + S+AL V
Sbjct: 239 LLLDSGINAHVRNTY-SQTAL---------DIVHQFTTSQASREIKQLLREASAALQVRA 288
Query: 938 ---HHGNVDLVRL 947
+ N DL L
Sbjct: 289 TKDYCNNYDLTSL 301
Score = 34.3 bits (77), Expect = 0.60
Identities = 50/224 (22%), Positives = 78/224 (34%), Gaps = 47/224 (20%)
Query: 82 PPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEATRQLE 141
PPA PP + + + P G + PP+ P +L + +L+
Sbjct: 1196 PPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKP---------------VLTQPVPKLQ 1240
Query: 142 AA-EPEDAELTF-GSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALP-PLQGEGS 198
+ P ++ G G P++ RA P P +S PP PP P P++
Sbjct: 1241 GSPTPTSKKVPLPGPGSPEVKRAHGTP-----------PPVSPKPPPPPTAPKPVKAVAG 1289
Query: 199 VCDGTFEPAEGLAGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFSFQNVL 258
+ G+ P S +P + + P + + P + P P PG P
Sbjct: 1290 LPSGSAGP--------SPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAP------A 1335
Query: 259 VVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLLEE 302
+ + K A A P P+PP SP LEE
Sbjct: 1336 LHVPAKPPRAAAAAAAAAAAP----PAPPEGASPGDSARQKLEE 1375
Score = 32.0 bits (71), Expect = 3.0
Identities = 52/207 (25%), Positives = 72/207 (34%), Gaps = 31/207 (14%)
Query: 96 PREASLGTQEQNQSPPLGNAPQASTSRSEVSYHR------KALLAEATRQLEAAEPEDAE 149
PR S G + + PPL ++T + + + K +L E+ P+ E
Sbjct: 1100 PRGPSKG-EAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTES--DTVKRRPKAKE 1156
Query: 150 LTFGSGRPQLLRA-SSMPATLLHSRASEEPGL-SLGPPAPPALPPLQGEGSVCDGTFEPA 207
G P L + T+ ASE+ G L PP PPA PP + P
Sbjct: 1157 REAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHL--PPLPPP 1214
Query: 208 EGLAGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFSFQNVLVVLEDKEDE 267
EG A + P + P L Q + +PLPGP
Sbjct: 1215 EGEARKPAKPPVSPK--PVLTQPVPKLQGSPTPTSKKVPLPGP---------------GS 1257
Query: 268 HNAREAEVLFTPGSPTPSPPP-LPSPI 293
+ A P SP P PPP P P+
Sbjct: 1258 PEVKRAHGTPPPVSPKPPPPPTAPKPV 1284
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 63.9 bits (154), Expect = 7e-10
Identities = 57/173 (32%), Positives = 79/173 (45%), Gaps = 15/173 (8%)
Query: 806 QPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMIT 865
Q SPH A NG T LH + + I LLE G N +
Sbjct: 620 QGASPH-------AAAKNGYTPLHIAAKKNQMDIATTLLEYGA----DANAVTRQGIASV 668
Query: 866 PLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQ 925
LA+ E + DM V L R NVN+ + + G T L L DR ++ + L++ A V+ Q
Sbjct: 669 HLAAQEGHVDM-VSLLLGRNANVNL-SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ 726
Query: 926 DHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTAL-SIALKSPTHM 977
G + L V CH+GN+ +V LL H A ++ T K G T L A + TH+
Sbjct: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHI 778
Score = 60.8 bits (146), Expect = 6e-09
Identities = 44/154 (28%), Positives = 74/154 (48%), Gaps = 7/154 (4%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
+++ G T LH + + + LLL+ + D K+G +TPL A ++
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSA-SPDAAGKSG-----LTPLHVAAHYDNQ 611
Query: 877 AVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 936
V LL +G A + G T L + ++ D+ LL AD N G +++ +A
Sbjct: 612 KVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLA 671
Query: 937 CHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
G+VD+V LLL A + +L++K+G T L +A
Sbjct: 672 AQEGHVDMVSLLLGRNA-NVNLSNKSGLTPLHLA 704
Score = 59.3 bits (142), Expect = 2e-08
Identities = 64/208 (30%), Positives = 90/208 (43%), Gaps = 24/208 (11%)
Query: 786 RVSSRKSSSPAVVASYLHEVQPHSPHFLKLL--------VNLADHNGNTALHYSVSHSNF 837
R RK S A ASYL + + H K L +N+ + NG ALH + +
Sbjct: 31 RSRDRKKKSDAN-ASYLRAAR--AGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHV 87
Query: 838 SIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQA-TQGG 896
+V LL+ NVD K G TA+ I LA A V K+L N+ A +Q G
Sbjct: 88 EVVSELLQREA-NVDAATKKGNTALHIASLAG------QAEVVKVLVTNGANVNAQSQNG 140
Query: 897 QTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDS 956
T L + + ++V+ LL A +L DG + L VA G+ +V LLL ++
Sbjct: 141 FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL-----EN 195
Query: 957 SLTDKAGRTALSIALKSPTHMEIAGLLR 984
K AL IA + A LL+
Sbjct: 196 DTKGKVRLPALHIAARKDDTKAAALLLQ 223
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/154 (28%), Positives = 71/154 (46%), Gaps = 9/154 (5%)
Query: 818 NLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITP-LASAETNEDM 876
N + G TALH + +V+ L++ G V+ + K T + I+ L A+
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGA-QVEAKAKDDQTPLHISARLGKAD----- 513
Query: 877 AVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 936
+V +LL++G AT G T L L ED+ LL A +++ G + L VA
Sbjct: 514 -IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVA 572
Query: 937 CHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
+G +++ LLL A + K+G T L +A
Sbjct: 573 AKYGKLEVANLLLQKSASPDA-AGKSGLTPLHVA 605
Score = 51.2 bits (121), Expect = 5e-06
Identities = 49/170 (28%), Positives = 76/170 (44%), Gaps = 8/170 (4%)
Query: 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDM 876
V+ N T LH + N ++VKLLL+ G +D + + G +TPL +
Sbjct: 261 VDFTARNDITPLHVASKRGNANMVKLLLDRG-AKIDAKTRDG-----LTPLHCGARSGHE 314
Query: 877 AVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 936
VV LL + T+ G + L + D + VQ LL V+ +D +AL VA
Sbjct: 315 QVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVA 374
Query: 937 CHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
H G+ + ++LL A + + G T L IA K +++ LL H
Sbjct: 375 AHCGHYKVAKVLLDKKA-NPNAKALNGFTPLHIACKK-NRIKVMELLLKH 422
Score = 50.4 bits (119), Expect = 8e-06
Identities = 42/126 (33%), Positives = 73/126 (57%), Gaps = 6/126 (4%)
Query: 867 LASAETNEDMAVVWKLL-REGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQ 925
LAS E + + VV +LL RE NV+ AT+ G TAL + + ++V+ L++ A+VN Q
Sbjct: 80 LASKEGHVE--VVSELLQREANVDA-ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
Query: 926 DHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRA 985
+G + L +A ++++V+ LL + A SL + G T L++AL+ H ++ LL
Sbjct: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGA-SQSLATEDGFTPLAVALQQ-GHDQVVSLLLE 194
Query: 986 HAEQGR 991
+ +G+
Sbjct: 195 NDTKGK 200
Score = 49.3 bits (116), Expect = 2e-05
Identities = 43/173 (24%), Positives = 81/173 (46%), Gaps = 11/173 (6%)
Query: 823 NGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKL 882
NG T LH + + +++LLL+ G ++ ++G +TP+ A + +V +L
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGA-SIQAVTESG-----LTPIHVAAFMGHVNIVSQL 452
Query: 883 LREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNV 942
+ G G+TAL + + ++V+ L+ A V + D + L ++ G
Sbjct: 453 MHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKA 512
Query: 943 DLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSLGL 995
D+V+ LL A ++ T +G T L ++ + H ++A L H G SL +
Sbjct: 513 DIVQQLLQQGASPNAAT-TSGYTPLHLSARE-GHEDVAAFLLDH---GASLSI 560
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/158 (30%), Positives = 68/158 (43%), Gaps = 8/158 (5%)
Query: 826 TALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLRE 885
T LH S IV+ LL+ G + + +GYT + L++ E +ED+A LL
Sbjct: 501 TPLHISARLGKADIVQQLLQQGA-SPNAATTSGYTPLH---LSAREGHEDVAAF--LLDH 554
Query: 886 GNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLV 945
G T+ G T L + + + ++ LL A + G + L VA H+ N V
Sbjct: 555 GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN-QKV 613
Query: 946 RLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
LLL K G T L IA K M+IA L
Sbjct: 614 ALLLLDQGASPHAAAKNGYTPLHIAAKK-NQMDIATTL 650
Score = 40.0 bits (92), Expect = 0.011
Identities = 42/166 (25%), Positives = 76/166 (45%), Gaps = 12/166 (7%)
Query: 818 NLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMA 877
+LA +G T L ++ + +V LLLE D + K A+ I +A ++ A
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLLEN-----DTKGKVRLPALHI----AARKDDTKA 217
Query: 878 VVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVAC 937
L + N ++++ + G T L + + ++ LL+ A V+ + + L VA
Sbjct: 218 AALLLQNDNNADVES-KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVAS 276
Query: 938 HHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
GN ++V+LLL A + T + G T L +S H ++ +L
Sbjct: 277 KRGNANMVKLLLDRGAKIDAKT-RDGLTPLHCGARS-GHEQVVEML 320
Score = 31.6 bits (70), Expect = 3.9
Identities = 35/139 (25%), Positives = 52/139 (37%), Gaps = 19/139 (13%)
Query: 184 PPAPPALPPLQGEGSVCDGTFEPAEGLAGFHSSSPRASTRIPELVQEGAEPPEGVVKVPN 243
PP+P +GS D T E L S S PE E K P+
Sbjct: 3141 PPSP--------QGSPEDDTLEQVSFL-----DSSGKSPLTPETPSSEEVSYEFTSKTPD 3187
Query: 244 HLP--LPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIP-ENELLL 300
L +PG P V E+ E+E A+ + T T +P+ + ++
Sbjct: 3188 SLIAYIPGKPSPIPEVS---EESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDSNQRP 3244
Query: 301 EEIELNISEIPPPPPVEVD 319
+ + E PPPPP++ D
Sbjct: 3245 KNNRVAYIEFPPPPPLDAD 3263
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 63.2 bits (152), Expect = 1e-09
Identities = 54/167 (32%), Positives = 80/167 (47%), Gaps = 9/167 (5%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVW 880
D G TALH + ++ K LL+ G + + Q+ +G T PL +A T + V
Sbjct: 1836 DRTGETALHLAARYARADAAKRLLDAGA-DTNAQDHSGRT-----PLHTAVTADAQGVFQ 1889
Query: 881 KLLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHH 939
L+R + ++ A G TAL+L E MV+ L++ ADVN D G SAL A
Sbjct: 1890 ILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAV 1949
Query: 940 GNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
NV+ LL + A + + D T L +A + ++ E A LL H
Sbjct: 1950 NNVEATLALLKNGA-NKDMQDSKEETPLFLAAREGSY-EAAKLLLDH 1994
Score = 49.3 bits (116), Expect = 2e-05
Identities = 41/166 (24%), Positives = 77/166 (46%), Gaps = 7/166 (4%)
Query: 818 NLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMA 877
N DH+G T LH +V+ + ++L+ ++D + G TA+++ + E
Sbjct: 1866 NAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVE-----G 1920
Query: 878 VVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVAC 937
+V +L+ + G++AL + + + ALL A+ ++QD + L +A
Sbjct: 1921 MVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAA 1980
Query: 938 HHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
G+ + +LLL H A + +TD R +A + H +I LL
Sbjct: 1981 REGSYEAAKLLLDHFA-NREITDHLDRLPRDVA-QERLHQDIVRLL 2024
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/136 (25%), Positives = 62/136 (45%), Gaps = 4/136 (2%)
Query: 857 AGYTAVMITPLASAETNED---MAVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMV 912
A + + P+ + E D +++ L+ +G + + + G+TAL L + R D
Sbjct: 1796 ASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAA 1855
Query: 913 QALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALK 972
+ LL AD N QDH G + L A + ++L+ + + D G TAL +A +
Sbjct: 1856 KRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAAR 1915
Query: 973 SPTHMEIAGLLRAHAE 988
+ L+ +HA+
Sbjct: 1916 LAVEGMVEELIASHAD 1931
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/168 (26%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVW 880
D G TA H + + + +++++ GV +V Q+ G++A+ + A N +
Sbjct: 53 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHL-----AAKNSHHECIR 106
Query: 881 KLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHG 940
KLL+ G+TAL + VQ L ++ +NL+D DG+ L++A +G
Sbjct: 107 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 166
Query: 941 NVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAE 988
+ ++ LL H A D + +K+GRTAL +A + + + L++ A+
Sbjct: 167 HSEICHFLLDHGA-DVNSRNKSGRTALMLACEIGSSNAVEALIKKGAD 213
Score = 45.8 bits (107), Expect = 2e-04
Identities = 41/139 (29%), Positives = 62/139 (44%), Gaps = 8/139 (5%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMIT-PLASAETNEDMAVV 879
D +G TALHY+ + V++L E H++ + PL A N +
Sbjct: 119 DSSGKTALHYAAAQGCLQAVQILCE-------HKSPINLKDLDGNIPLLLAVQNGHSEIC 171
Query: 880 WKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHH 939
LL G + G+TALML + V+AL+ AD+NL D G +AL +
Sbjct: 172 HFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLS 231
Query: 940 GNVDLVRLLLAHPACDSSL 958
N + LLL+ + D+ L
Sbjct: 232 ENAGIQSLLLSKISQDADL 250
Score = 41.6 bits (96), Expect = 0.004
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Query: 867 LASAETNEDMAVVWKLL-REGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQ 925
L A N D V LL ++G + G+TA L + + ++ +++ DV Q
Sbjct: 26 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 85
Query: 926 DHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
D G SAL +A + + + +R LL C + D +G+TAL A
Sbjct: 86 DTTGHSALHLAAKNSHHECIRKLL-QSKCPAESVDSSGKTALHYA 129
Score = 35.4 bits (80), Expect = 0.27
Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 11/106 (10%)
Query: 342 ISSLKQQVSALEGELSGRTEELAQV---RTALQQQEEEIKAREQRIRELEFTVAQLEGQF 398
++ LKQ V A + TE L + RTA ++ EE+I ++ + E VA+LE Q
Sbjct: 716 LTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 775
Query: 399 HQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESES 444
+E A TD MV L + S + EV++L S ES
Sbjct: 776 LEEKA----AMTDAMVPRSSYEKL--QSSLES--EVSVLASKLKES 813
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/168 (26%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVW 880
D G TA H + + + +++++ GV +V Q+ G++A+ + A N +
Sbjct: 42 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHL-----AAKNSHHECIR 95
Query: 881 KLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHG 940
KLL+ G+TAL + VQ L ++ +NL+D DG+ L++A +G
Sbjct: 96 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 155
Query: 941 NVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAE 988
+ ++ LL H A D + +K+GRTAL +A + + + L++ A+
Sbjct: 156 HSEICHFLLDHGA-DVNSRNKSGRTALMLACEIGSSNAVEALIKKGAD 202
Score = 45.8 bits (107), Expect = 2e-04
Identities = 41/139 (29%), Positives = 62/139 (44%), Gaps = 8/139 (5%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMIT-PLASAETNEDMAVV 879
D +G TALHY+ + V++L E H++ + PL A N +
Sbjct: 108 DSSGKTALHYAAAQGCLQAVQILCE-------HKSPINLKDLDGNIPLLLAVQNGHSEIC 160
Query: 880 WKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHH 939
LL G + G+TALML + V+AL+ AD+NL D G +AL +
Sbjct: 161 HFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLS 220
Query: 940 GNVDLVRLLLAHPACDSSL 958
N + LLL+ + D+ L
Sbjct: 221 ENAGIQSLLLSKISQDADL 239
Score = 41.6 bits (96), Expect = 0.004
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Query: 867 LASAETNEDMAVVWKLL-REGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQ 925
L A N D V LL ++G + G+TA L + + ++ +++ DV Q
Sbjct: 15 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 74
Query: 926 DHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
D G SAL +A + + + +R LL C + D +G+TAL A
Sbjct: 75 DTTGHSALHLAAKNSHHECIRKLL-QSKCPAESVDSSGKTALHYA 118
Score = 35.4 bits (80), Expect = 0.27
Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 11/106 (10%)
Query: 342 ISSLKQQVSALEGELSGRTEELAQV---RTALQQQEEEIKAREQRIRELEFTVAQLEGQF 398
++ LKQ V A + TE L + RTA ++ EE+I ++ + E VA+LE Q
Sbjct: 705 LTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 764
Query: 399 HQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESES 444
+E A TD MV L + S + EV++L S ES
Sbjct: 765 LEEKA----AMTDAMVPRSSYEKL--QSSLES--EVSVLASKLKES 802
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/168 (26%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVW 880
D G TA H + + + +++++ GV +V Q+ G++A+ + A N +
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHL-----AAKNSHHECIR 103
Query: 881 KLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHG 940
KLL+ G+TAL + VQ L ++ +NL+D DG+ L++A +G
Sbjct: 104 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 163
Query: 941 NVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAE 988
+ ++ LL H A D + +K+GRTAL +A + + + L++ A+
Sbjct: 164 HSEICHFLLDHGA-DVNSRNKSGRTALMLACEIGSSNAVEALIKKGAD 210
Score = 45.8 bits (107), Expect = 2e-04
Identities = 41/139 (29%), Positives = 62/139 (44%), Gaps = 8/139 (5%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMIT-PLASAETNEDMAVV 879
D +G TALHY+ + V++L E H++ + PL A N +
Sbjct: 116 DSSGKTALHYAAAQGCLQAVQILCE-------HKSPINLKDLDGNIPLLLAVQNGHSEIC 168
Query: 880 WKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHH 939
LL G + G+TALML + V+AL+ AD+NL D G +AL +
Sbjct: 169 HFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLS 228
Query: 940 GNVDLVRLLLAHPACDSSL 958
N + LLL+ + D+ L
Sbjct: 229 ENAGIQSLLLSKISQDADL 247
Score = 41.6 bits (96), Expect = 0.004
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Query: 867 LASAETNEDMAVVWKLL-REGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQ 925
L A N D V LL ++G + G+TA L + + ++ +++ DV Q
Sbjct: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
Query: 926 DHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
D G SAL +A + + + +R LL C + D +G+TAL A
Sbjct: 83 DTTGHSALHLAAKNSHHECIRKLL-QSKCPAESVDSSGKTALHYA 126
Score = 35.4 bits (80), Expect = 0.27
Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 11/106 (10%)
Query: 342 ISSLKQQVSALEGELSGRTEELAQV---RTALQQQEEEIKAREQRIRELEFTVAQLEGQF 398
++ LKQ V A + TE L + RTA ++ EE+I ++ + E VA+LE Q
Sbjct: 684 LTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 743
Query: 399 HQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESES 444
+E A TD MV L + S + EV++L S ES
Sbjct: 744 LEEKA----AMTDAMVPRSSYEKL--QSSLES--EVSVLASKLKES 781
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/168 (26%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVW 880
D G TA H + + + +++++ GV +V Q+ G++A+ + A N +
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHL-----AAKNSHHECIR 103
Query: 881 KLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHG 940
KLL+ G+TAL + VQ L ++ +NL+D DG+ L++A +G
Sbjct: 104 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 163
Query: 941 NVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAE 988
+ ++ LL H A D + +K+GRTAL +A + + + L++ A+
Sbjct: 164 HSEICHFLLDHGA-DVNSRNKSGRTALMLACEIGSSNAVEALIKKGAD 210
Score = 45.8 bits (107), Expect = 2e-04
Identities = 41/139 (29%), Positives = 62/139 (44%), Gaps = 8/139 (5%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMIT-PLASAETNEDMAVV 879
D +G TALHY+ + V++L E H++ + PL A N +
Sbjct: 116 DSSGKTALHYAAAQGCLQAVQILCE-------HKSPINLKDLDGNIPLLLAVQNGHSEIC 168
Query: 880 WKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHH 939
LL G + G+TALML + V+AL+ AD+NL D G +AL +
Sbjct: 169 HFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLS 228
Query: 940 GNVDLVRLLLAHPACDSSL 958
N + LLL+ + D+ L
Sbjct: 229 ENAGIQSLLLSKISQDADL 247
Score = 41.6 bits (96), Expect = 0.004
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Query: 867 LASAETNEDMAVVWKLL-REGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQ 925
L A N D V LL ++G + G+TA L + + ++ +++ DV Q
Sbjct: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
Query: 926 DHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
D G SAL +A + + + +R LL C + D +G+TAL A
Sbjct: 83 DTTGHSALHLAAKNSHHECIRKLL-QSKCPAESVDSSGKTALHYA 126
Score = 35.4 bits (80), Expect = 0.27
Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 11/106 (10%)
Query: 342 ISSLKQQVSALEGELSGRTEELAQV---RTALQQQEEEIKAREQRIRELEFTVAQLEGQF 398
++ LKQ V A + TE L + RTA ++ EE+I ++ + E VA+LE Q
Sbjct: 713 LTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 772
Query: 399 HQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESES 444
+E A TD MV L + S + EV++L S ES
Sbjct: 773 LEEKA----AMTDAMVPRSSYEKL--QSSLES--EVSVLASKLKES 810
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/168 (26%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVW 880
D G TA H + + + +++++ GV +V Q+ G++A+ + A N +
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHL-----AAKNSHHECIR 103
Query: 881 KLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHG 940
KLL+ G+TAL + VQ L ++ +NL+D DG+ L++A +G
Sbjct: 104 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 163
Query: 941 NVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAE 988
+ ++ LL H A D + +K+GRTAL +A + + + L++ A+
Sbjct: 164 HSEICHFLLDHGA-DVNSRNKSGRTALMLACEIGSSNAVEALIKKGAD 210
Score = 45.8 bits (107), Expect = 2e-04
Identities = 41/139 (29%), Positives = 62/139 (44%), Gaps = 8/139 (5%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMIT-PLASAETNEDMAVV 879
D +G TALHY+ + V++L E H++ + PL A N +
Sbjct: 116 DSSGKTALHYAAAQGCLQAVQILCE-------HKSPINLKDLDGNIPLLLAVQNGHSEIC 168
Query: 880 WKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHH 939
LL G + G+TALML + V+AL+ AD+NL D G +AL +
Sbjct: 169 HFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLS 228
Query: 940 GNVDLVRLLLAHPACDSSL 958
N + LLL+ + D+ L
Sbjct: 229 ENAGIQSLLLSKISQDADL 247
Score = 41.6 bits (96), Expect = 0.004
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Query: 867 LASAETNEDMAVVWKLL-REGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQ 925
L A N D V LL ++G + G+TA L + + ++ +++ DV Q
Sbjct: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
Query: 926 DHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
D G SAL +A + + + +R LL C + D +G+TAL A
Sbjct: 83 DTTGHSALHLAAKNSHHECIRKLL-QSKCPAESVDSSGKTALHYA 126
Score = 35.4 bits (80), Expect = 0.27
Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 11/106 (10%)
Query: 342 ISSLKQQVSALEGELSGRTEELAQV---RTALQQQEEEIKAREQRIRELEFTVAQLEGQF 398
++ LKQ V A + TE L + RTA ++ EE+I ++ + E VA+LE Q
Sbjct: 713 LTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 772
Query: 399 HQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESES 444
+E A TD MV L + S + EV++L S ES
Sbjct: 773 LEEKA----AMTDAMVPRSSYEKL--QSSLES--EVSVLASKLKES 810
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/168 (26%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVW 880
D G TA H + + + +++++ GV +V Q+ G++A+ + A N +
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHL-----AAKNSHHECIR 103
Query: 881 KLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHG 940
KLL+ G+TAL + VQ L ++ +NL+D DG+ L++A +G
Sbjct: 104 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 163
Query: 941 NVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAE 988
+ ++ LL H A D + +K+GRTAL +A + + + L++ A+
Sbjct: 164 HSEICHFLLDHGA-DVNSRNKSGRTALMLACEIGSSNAVEALIKKGAD 210
Score = 45.8 bits (107), Expect = 2e-04
Identities = 41/139 (29%), Positives = 62/139 (44%), Gaps = 8/139 (5%)
Query: 821 DHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMIT-PLASAETNEDMAVV 879
D +G TALHY+ + V++L E H++ + PL A N +
Sbjct: 116 DSSGKTALHYAAAQGCLQAVQILCE-------HKSPINLKDLDGNIPLLLAVQNGHSEIC 168
Query: 880 WKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHH 939
LL G + G+TALML + V+AL+ AD+NL D G +AL +
Sbjct: 169 HFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLS 228
Query: 940 GNVDLVRLLLAHPACDSSL 958
N + LLL+ + D+ L
Sbjct: 229 ENAGIQSLLLSKISQDADL 247
Score = 41.6 bits (96), Expect = 0.004
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Query: 867 LASAETNEDMAVVWKLL-REGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQ 925
L A N D V LL ++G + G+TA L + + ++ +++ DV Q
Sbjct: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
Query: 926 DHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
D G SAL +A + + + +R LL C + D +G+TAL A
Sbjct: 83 DTTGHSALHLAAKNSHHECIRKLL-QSKCPAESVDSSGKTALHYA 126
Score = 35.4 bits (80), Expect = 0.27
Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 11/106 (10%)
Query: 342 ISSLKQQVSALEGELSGRTEELAQV---RTALQQQEEEIKAREQRIRELEFTVAQLEGQF 398
++ LKQ V A + TE L + RTA ++ EE+I ++ + E VA+LE Q
Sbjct: 713 LTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 772
Query: 399 HQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESES 444
+E A TD MV L + S + EV++L S ES
Sbjct: 773 LEEKA----AMTDAMVPRSSYEKL--QSSLES--EVSVLASKLKES 810
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 62.8 bits (151), Expect = 2e-09
Identities = 59/187 (31%), Positives = 87/187 (46%), Gaps = 19/187 (10%)
Query: 816 LVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITP--------- 866
+VN+AD T LH + + + I KLLL+ G + +N+ G T + +
Sbjct: 584 VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGA-DPTKKNRDGNTPLDLVKDGDTDIQDL 642
Query: 867 ------LASAETNEDMAVVWKLLREGNVNIQATQGGQ-TALMLGVSHDREDMVQALLSCQ 919
L A +A V KL NVN + TQG T L L ++ ++ + LL
Sbjct: 643 LRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG 702
Query: 920 ADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEI 979
ADVN QD G L A +G+VD+ LL+ + AC ++ TDK T L A + ++
Sbjct: 703 ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA-TDKWAFTPLHEAAQK-GRTQL 760
Query: 980 AGLLRAH 986
LL AH
Sbjct: 761 CALLLAH 767
Score = 54.7 bits (130), Expect = 4e-07
Identities = 59/226 (26%), Positives = 98/226 (43%), Gaps = 39/226 (17%)
Query: 755 CRALSQHLPETGTTTDQLLRQ--SLNTISQEWF---RVSSRKSSSPAVVASYLHEVQPHS 809
C A S + P+ + LLR+ ++N ++E+ V+S K+ + V HE +
Sbjct: 370 CAAASPY-PKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK--- 425
Query: 810 PHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMI----- 864
VN D+ G T+LH + + +LLL G C+ + + G+TA+ +
Sbjct: 426 -------VNALDNLGQTSLHRAAYCGHLQTCRLLLSYG-CDPNIISLQGFTALQMGNENV 477
Query: 865 ----------------TPLASAETNEDMAVVWKLLREGNVNIQATQGGQ-TALMLGVSHD 907
L A D+ V KL +VN + +G Q T L ++
Sbjct: 478 QQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN 537
Query: 908 REDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPA 953
R +V+ LL ADV+ +D G L AC +G+ ++ LL+ H A
Sbjct: 538 RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGA 583
Score = 46.2 bits (108), Expect = 2e-04
Identities = 45/157 (28%), Positives = 71/157 (45%), Gaps = 17/157 (10%)
Query: 818 NLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAV-MITPLASA----ET 872
N D+ T LH + + +LL+ G +N G TA+ + P A A E
Sbjct: 118 NARDNWNYTPLHEAAIKGKIDVCIVLLQHGA-EPTIRNTDGRTALDLADPSAKAVLTGEY 176
Query: 873 NEDMAV----------VWKLLREGNVNIQATQGGQ-TALMLGVSHDREDMVQALLSCQAD 921
+D + + LL NVN A+ G + T L L ++R +VQ LL AD
Sbjct: 177 KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD 236
Query: 922 VNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSL 958
V+ +D L AC +G+ ++ LL+ H AC +++
Sbjct: 237 VHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM 273
Score = 44.3 bits (103), Expect = 6e-04
Identities = 33/113 (29%), Positives = 60/113 (53%), Gaps = 3/113 (2%)
Query: 882 LLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHG 940
LLR+G N+N + T+ T L + D+V+ ++ +A VN D+ G ++L A + G
Sbjct: 386 LLRKGANIN-EKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCG 444
Query: 941 NVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSL 993
++ RLLL++ CD ++ G TAL + ++ + G+ ++E R L
Sbjct: 445 HLQTCRLLLSY-GCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQL 496
Score = 43.1 bits (100), Expect = 0.001
Identities = 35/102 (34%), Positives = 49/102 (48%), Gaps = 2/102 (1%)
Query: 867 LASAETNEDMAVVWKLLREGNVNIQATQGGQ-TALMLGVSHDREDMVQALLSCQADVNLQ 925
L A N D+ V +L+ VN + T G + T L R+D+V+ LL A+V +
Sbjct: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
Query: 926 DHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTAL 967
D G L AC G+ ++V LLL H A D + D T L
Sbjct: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGA-DPNARDNWNYTPL 128
Score = 40.4 bits (93), Expect = 0.008
Identities = 37/107 (34%), Positives = 52/107 (48%), Gaps = 3/107 (2%)
Query: 865 TPLASAETNEDMAVVWKLLREGNVNIQATQ-GGQTALMLGVSHDREDMVQALLSCQADVN 923
TPL A VV LL+ G N+QA GG L S ++V LL AD N
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQNG-ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
Query: 924 LQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 970
+D+ + L A G +D+ +LL H A + ++ + GRTAL +A
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGA-EPTIRNTDGRTALDLA 164
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.129 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,128,199
Number of Sequences: 37866
Number of extensions: 2665277
Number of successful extensions: 21277
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 375
Number of HSP's successfully gapped in prelim test: 737
Number of HSP's that attempted gapping in prelim test: 15066
Number of HSP's gapped (non-prelim): 5517
length of query: 995
length of database: 18,247,518
effective HSP length: 112
effective length of query: 883
effective length of database: 14,006,526
effective search space: 12367762458
effective search space used: 12367762458
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.