Search of human proteins with 15529998

Search of human proteins with 15529998

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15529998 solute carrier family 9 (sodium/hydrogen
exchanger), member 2 [Homo sapiens]
         (812 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15529998 solute carrier family 9 (sodium/hydrogen exchanger),...  1613   0.0  
gi|148727259 solute carrier family 9 (sodium/hydrogen exchanger)...   831   0.0  
gi|27777632 solute carrier family 9, isoform A1 [Homo sapiens]        662   0.0  
gi|194239733 solute carrier family 9 (sodium/hydrogen exchanger)...   539   e-153
gi|4759144 solute carrier family 9 (sodium/hydrogen exchanger), ...   526   e-149
gi|41872703 sodium/hydrogen exchanger 8 [Homo sapiens]                220   4e-57
gi|5454070 solute carrier family 9 (sodium/hydrogen exchanger), ...   199   7e-51
gi|27734935 solute carrier family 9 (sodium/hydrogen exchanger),...   199   7e-51
gi|110227626 solute carrier family 9 (sodium/hydrogen exchanger)...   192   1e-48
gi|14211919 solute carrier family 9, member 7 [Homo sapiens]          181   3e-45
gi|56786136 sperm-specific sodium proton exchanger [Homo sapiens]      63   1e-09
gi|224465231 solute carrier family 9, member 11 [Homo sapiens]         54   8e-07
gi|50843827 activating molecule in beclin-1-regulated autophagy ...    39   0.025
gi|160707881 formin 2 [Homo sapiens]                                   35   0.21 
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    35   0.28 
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     35   0.36 
gi|4557719 DNA ligase I [Homo sapiens]                                 34   0.48 
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]            34   0.62 
gi|161169017 neuron navigator 2 isoform 4 [Homo sapiens]               34   0.62 
gi|161169015 neuron navigator 2 isoform 3 [Homo sapiens]               34   0.62 
gi|38044282 neuron navigator 2 isoform 2 [Homo sapiens]                34   0.62 
gi|116812577 LUC7-like 2 [Homo sapiens]                                34   0.62 
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...    33   0.81 
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...    33   0.81 
gi|93204867 G protein-coupled receptor 158 [Homo sapiens]              33   0.81 
gi|112421108 capicua homolog [Homo sapiens]                            33   0.81 
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi...    33   1.1  
gi|56549694 enabled homolog isoform a [Homo sapiens]                   33   1.1  
gi|39930375 enabled homolog isoform b [Homo sapiens]                   33   1.1  
gi|56847634 hypothetical protein LOC441294 [Homo sapiens]              33   1.1  

>gi|15529998 solute carrier family 9 (sodium/hydrogen exchanger),
           member 2 [Homo sapiens]
          Length = 812

 Score = 1613 bits (4176), Expect = 0.0
 Identities = 812/812 (100%), Positives = 812/812 (100%)

Query: 1   MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGT 60
           MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGT
Sbjct: 1   MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGT 60

Query: 61  TLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLL 120
           TLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLL
Sbjct: 61  TLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLL 120

Query: 121 LGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWN 180
           LGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWN
Sbjct: 121 LGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWN 180

Query: 181 SIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVF 240
           SIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVF
Sbjct: 181 SIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVF 240

Query: 241 GESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTT 300
           GESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTT
Sbjct: 241 GESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTT 300

Query: 301 RFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIK 360
           RFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIK
Sbjct: 301 RFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIK 360

Query: 361 YFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFR 420
           YFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFR
Sbjct: 361 YFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFR 420

Query: 421 TIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIR 480
           TIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIR
Sbjct: 421 TIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIR 480

Query: 481 PLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRK 540
           PLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRK
Sbjct: 481 PLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRK 540

Query: 541 LLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDE 600
           LLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDE
Sbjct: 541 LLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDE 600

Query: 601 IRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRA 660
           IRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRA
Sbjct: 601 IRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRA 660

Query: 661 STSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFS 720
           STSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFS
Sbjct: 661 STSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFS 720

Query: 721 KKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDS 780
           KKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDS
Sbjct: 721 KKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDS 780

Query: 781 LTEGIPPKPPPRLVWRASEPGSRKARFGSEKP 812
           LTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
Sbjct: 781 LTEGIPPKPPPRLVWRASEPGSRKARFGSEKP 812


>gi|148727259 solute carrier family 9 (sodium/hydrogen exchanger),
           member 4 [Homo sapiens]
          Length = 798

 Score =  831 bits (2147), Expect = 0.0
 Identities = 413/651 (63%), Positives = 512/651 (78%), Gaps = 9/651 (1%)

Query: 65  ESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGI 124
           E  + VF LDY +VQIP+E+TLWILLASLAKIGFHLYH+LP ++PESCLLI+VG L+GGI
Sbjct: 54  EEGISVFELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPGLMPESCLLILVGALVGGI 113

Query: 125 IFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGI 184
           IFG D KSPP M + ++FLYLLPPIVL+ GYFMPTRPFFENIG+I W+AV+G L N++GI
Sbjct: 114 IFGTDHKSPPVMDSSIYFLYLLPPIVLEGGYFMPTRPFFENIGSILWWAVLGALINALGI 173

Query: 185 GVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESL 244
           G+SL+ ICQ++AFGL D+ LLQNLLFGSLISAVDPVAVLAVFE   VNEQLY+++FGE+L
Sbjct: 174 GLSLYLICQVKAFGLGDVNLLQNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEAL 233

Query: 245 LNDAVTVVLYNLFKSFCQM---KTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTR 301
           LND +TVVLYN+  +F +M   + IET+D+ AG A F VVG+GGVL GI  GFI+AF TR
Sbjct: 234 LNDGITVVLYNMLIAFTKMHKFEDIETVDILAGCARFIVVGLGGVLFGIVFGFISAFITR 293

Query: 302 FTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKY 361
           FT NI  IEPL VF++SYLSY+ AE  +LSGI+AITACA+TM KYVEENVSQ SYTTIKY
Sbjct: 294 FTQNISAIEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKY 353

Query: 362 FMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRT 421
           FMKMLSSVSETLIFIFMGVSTVGKNHEWNWAF+CFTLAFC +WRA+ VF L  + N+FRT
Sbjct: 354 FMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFICFTLAFCQIWRAISVFALFYISNQFRT 413

Query: 422 IPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRP 481
            P + KDQ II Y G+RGA  F+L FLLP ++FPRKK+F+TA +VVI+FTVFI GIT+ P
Sbjct: 414 FPFSIKDQCIIFYSGVRGAGSFSLAFLLPLSLFPRKKMFVTATLVVIYFTVFIQGITVGP 473

Query: 482 LVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKL 541
           LV +LDVK++NKK ++++EE++ RL DH+K GIEDVCGHW H   RDKFKKFD +YLRK+
Sbjct: 474 LVRYLDVKKTNKK-ESINEELHIRLMDHLKAGIEDVCGHWSHYQVRDKFKKFDHRYLRKI 532

Query: 542 LIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEI 601
           LIR+N PKSSIVSLYKKLE+K AIEM ETG++S+          R + I++++  + + I
Sbjct: 533 LIRKNLPKSSIVSLYKKLEMKQAIEMVETGILSSTAFSIPHQAQRIQGIKRLSPEDVESI 592

Query: 602 RELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRAS 661
           R++L+ N+YQ+RQRTLSYN+++L   TSE+QAKEILIRR+++LRES+RK  SL     A 
Sbjct: 593 RDILTSNMYQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESMRKGHSLPWGKPAG 652

Query: 662 TSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRAR 712
           T   RYLS P         Q     + A G S D  +D G+  +     +R
Sbjct: 653 TKNIRYLSYPYGNP-----QSAGRDTRAAGFSDDDSSDPGSPSITFSACSR 698


>gi|27777632 solute carrier family 9, isoform A1 [Homo sapiens]
          Length = 815

 Score =  662 bits (1707), Expect = 0.0
 Identities = 368/771 (47%), Positives = 500/771 (64%), Gaps = 53/771 (6%)

Query: 45  TSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKL 104
           T  S P   SV   G  +      PV  +DY HV+ PFEI+LWILLA L KIGFH+   +
Sbjct: 68  TPESRPVNHSVTDHG--MKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTI 125

Query: 105 PTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFE 164
            +IVPESCLLI+VGLL+GG+I GV E +PP +++DVFFL+LLPPI+LDAGYF+P R F E
Sbjct: 126 SSIVPESCLLIVVGLLVGGLIKGVGE-TPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTE 184

Query: 165 NIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLA 224
           N+GTI  +AVVGTLWN+  +G  ++ +C +    +++I LL NLLFGS+ISAVDPVAVLA
Sbjct: 185 NLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLA 244

Query: 225 VFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIG 284
           VFE IH+NE L+ILVFGESLLNDAVTVVLY+LF+ F   + +  +D+F G  +FFVV +G
Sbjct: 245 VFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALG 304

Query: 285 GVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMN 344
           GVL+G+  G IAAFT+RFT +IRVIEPLFVFLYSY++Y++AE+FHLSGIMA+ A  + M 
Sbjct: 305 GVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMR 364

Query: 345 KYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMW 404
            YVE N+S KS+TTIKYF+KM SSVSETLIFIF+GVSTV  +H WNW FV  TL FCL+ 
Sbjct: 365 PYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIA 424

Query: 405 RALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAA 464
           R LGV  LT  IN+FR + LT KDQFIIAYGGLRGAI F+L +LL    FP   LF+TA 
Sbjct: 425 RVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAI 484

Query: 465 IVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHN 524
           I VIFFTVF+ G+TIRPLV+ L VK+  + +++++EEI+ +  DH+ TGIED+CGH+GH+
Sbjct: 485 ITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHH 544

Query: 525 FWRDKFKKFDDKYLRKLLIR-ENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLN 583
            W+DK  +F+ KY++K LI  E   +  +++ Y K+E+K AIE+ E+G +  +P+  S  
Sbjct: 545 HWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTV 604

Query: 584 DCR---------EEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAK 634
             +         E  +  ++  + +EIR++L  NL + RQR  SYNRH+L AD  E    
Sbjct: 605 SMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWN 664

Query: 635 EILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSS 694
           ++L+RR+              +  +     + YL++P + KL      R  I  +D  + 
Sbjct: 665 QMLLRRQ--------------KARQLEQKINNYLTVPAH-KLDSPTMSRARIG-SDPLAY 708

Query: 695 DSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKM---EWKNEVDVDSGRDMPSTPPTPH 751
           +   D    V+ + P          S +SP+S  +   E K +V +   RD     P   
Sbjct: 709 EPKED--LPVITIDPA---------SPQSPESVDLVNEELKGKV-LGLSRD-----PAKV 751

Query: 752 SREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRA-SEPG 801
           + E      G++ +   SK+ S    +D  T      P  + + R  S+PG
Sbjct: 752 AEEDEDDDGGIMMR---SKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPG 799


>gi|194239733 solute carrier family 9 (sodium/hydrogen exchanger),
           isoform 3 [Homo sapiens]
          Length = 834

 Score =  539 bits (1389), Expect = e-153
 Identities = 303/679 (44%), Positives = 417/679 (61%), Gaps = 54/679 (7%)

Query: 56  VAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLI 115
           V PG    E     V T ++ HVQ P+ I LWIL+ASLAKIGFHL HK+ ++VPES LLI
Sbjct: 30  VEPGGAHGESGGFQVVTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLI 89

Query: 116 MVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVV 175
           ++GL+LGGI++  D  +   +   VFF YLLPPIVLDAGYFMP R FF N+GTI  YAVV
Sbjct: 90  VLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVV 149

Query: 176 GTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQL 235
           GT+WN+   G+SL+G+      G   I LL  LLFGSL++AVDPVAVLAVFE +HVNE L
Sbjct: 150 GTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVL 209

Query: 236 YILVFGESLLNDAVTVVLYNLFKSFCQM--KTIETIDVFAGIANFFVVGIGGVLIGIFLG 293
           +I+VFGESLLNDAVTVVLYN+F+SF  +    +  +D   GI +FFVV +GG L+G+   
Sbjct: 210 FIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFA 269

Query: 294 FIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQ 353
           F+ +  TRFT ++R+IEP FVF+ SYLSY+T+EM  LS I+AIT C +   KYV+ N+S+
Sbjct: 270 FLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISE 329

Query: 354 KSYTTIKYFMKMLSSVSETLIFIFMGVSTVGK-NHEWNWAFVCFTLAFCLMWRALGVFVL 412
           +S TT++Y MKML+S +ET+IF+F+G+S V      WN AFV  TL F  ++RA+GV + 
Sbjct: 330 QSATTVRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQ 389

Query: 413 TQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTV 472
           T ++NR+R + L   DQ +++YGGLRGA+ FALV LL       K LF++  I+V+FFTV
Sbjct: 390 TWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTV 449

Query: 473 FILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKK 532
              G+TI+PLV++L VKRS  ++  ++E+++ R FDH+ + IED+ G  GHN+ RDK+  
Sbjct: 450 IFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSH 509

Query: 533 FDDKYLRKLLIRENQPKS--SIVSLYKKLEIKHAIEMAETG------------------- 571
           FD K+L ++L+R +  KS   I++++ +L +K AI     G                   
Sbjct: 510 FDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNVVN 569

Query: 572 -----MISTVPTFASL------------NDCREEKIRKVTSSETDEIRELLSRNLYQIRQ 614
                  STV    S                 E++ R +  +E       L + LY+ RQ
Sbjct: 570 VDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYLYKPRQ 629

Query: 615 RTLS-YNRHSLTADTSERQAKEILIRRRHSLRESIRKDS-SLNREHRASTSTSRYLSLPK 672
                Y+RH LT    E+Q +EI  R      ES +     LN+  +A+    R      
Sbjct: 630 EYKHLYSRHELTPTEDEKQDREIFHRTMRKRLESFKSTKLGLNQNKKAAKLYKR------ 683

Query: 673 NTKLPEKLQKRRTISIADG 691
                E+ QKRR  SI +G
Sbjct: 684 -----ERAQKRRNSSIPNG 697


>gi|4759144 solute carrier family 9 (sodium/hydrogen exchanger),
           isoform 5 [Homo sapiens]
          Length = 896

 Score =  526 bits (1355), Expect = e-149
 Identities = 310/755 (41%), Positives = 441/755 (58%), Gaps = 71/755 (9%)

Query: 17  MLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGTTLFEESRLPVFTLDYP 76
           ML   L  +A P+   AE     P + G    PP       PG        L +F   + 
Sbjct: 1   MLRAALSLLALPLAGAAEEPTQKPESPG---EPP-------PG--------LELFRWQWH 42

Query: 77  HVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAM 136
            V+ P+ + LWIL+ASLAKI FHL  K+ ++VPESCLLI++GL+LGGI+  V +K+   +
Sbjct: 43  EVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQL 102

Query: 137 KTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEA 196
           +   FFL+LLPPIVLD+GYFMP+R FF+N+G I  YAVVGTLWN+   G +L+G+ Q   
Sbjct: 103 EPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGL 162

Query: 197 FGLS-DITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYN 255
                   LL  LLFGSLISAVDPVAVLAVFE +HVNE L+I+VFGESLLNDAVTVVLY 
Sbjct: 163 VAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYK 222

Query: 256 LFKSFCQMKT--IETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLF 313
           +  SF +M +  ++  D   G+A+ FVV +GG  +G+   F+ A TTRFT  +R+IEPL 
Sbjct: 223 VCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLL 282

Query: 314 VFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETL 373
           VFL +Y +Y+TAEM  LS I+A+T C +   KYVE N+S KS TT+KY MK L+S +ET+
Sbjct: 283 VFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETV 342

Query: 374 IFIFMGVSTVGKNHEWNW--AFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFI 431
           IF+ +G+S V  + +W W    V  TL F L +RALGV + T V+N+FR +PL   DQ +
Sbjct: 343 IFMLLGISAVDSS-KWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVV 401

Query: 432 IAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRS 491
           ++YGGLRGA+ FALV LL     P K  F+   IVV+FFTV + G+TI+PLV++L VKRS
Sbjct: 402 MSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRS 461

Query: 492 NKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIREN--QPK 549
              +  +++E++   FDH+   +EDV GH G+++WRD++++FD KYL +LL+R +  + +
Sbjct: 462 EHHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIR 521

Query: 550 SSIVSLYKKLEIKHAIEMAETG--MIS----TVPTFASLNDCRE---------------- 587
             I  +Y +L I+ AI   + G  ++S    T+P+  S N   E                
Sbjct: 522 DQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACL 581

Query: 588 -----EKIRKVTSSETDEIRELLSRNLYQIRQR-TLSYNRHSLTADTSERQAKEILIRRR 641
                + +R     E   +  LL   LY+ R+R   S +RH ++ D  ERQ KE+     
Sbjct: 582 DLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVF---- 637

Query: 642 HSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAG 701
                      ++ R   +  ST   +   K+   P K  +R+   +A+  +++      
Sbjct: 638 ---------QQNMKRRLESFKSTKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKHRG- 687

Query: 702 TTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVD 736
              L  Q  A   L  +  ++  +S   E + E D
Sbjct: 688 ---LGFQDTAAVILTVESEEEEEESDSSETEKEDD 719


>gi|41872703 sodium/hydrogen exchanger 8 [Homo sapiens]
          Length = 581

 Score =  220 bits (561), Expect = 4e-57
 Identities = 134/409 (32%), Positives = 229/409 (55%), Gaps = 18/409 (4%)

Query: 108 VPESCLLIMVGLLLGGIIFGVDEKSPPAMKTD------VFFLYLLPPIVLDAGYFMPTRP 161
           +PES  ++ +G+L+G +I  ++ K     K +      +FFL LLPPI+ ++GY +    
Sbjct: 87  LPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGN 146

Query: 162 FFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVA 221
           FF+NIG+I  +AV GT  ++  +G  ++ + Q +   +S + +  +  FGSLISAVDPVA
Sbjct: 147 FFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADV--ISKLNMTDSFAFGSLISAVDPVA 204

Query: 222 VLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQ--MKTIETIDVFAGIANFF 279
            +A+F  +HV+  L +LVFGES+LNDAV++VL N  +   +  M  +     F    ++F
Sbjct: 205 TIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYF 264

Query: 280 V-VGIGGVLIGIFLGFIAAFTTRFTHNIRV--IEPLFVFLYSYLSYITAEMFHLSGIMAI 336
           + +  G   +G   G I+A   +     +   +E   + +++YL Y  AE   LSGIMAI
Sbjct: 265 LKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAI 324

Query: 337 TACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCF 396
               + M+ Y   N+S  +   ++  ++ ++ + ET +F F+G+S     H++  +FV +
Sbjct: 325 LFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEISFVIW 384

Query: 397 TLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPR 456
            +   L  RA+ +F L+ ++N FR   +T K  FI+ + GLRGAI +AL   L      +
Sbjct: 385 CIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEK 444

Query: 457 KKLFITAAIVVIFFTVFILGITIRPLVEFLDVK-----RSNKKQQAVSE 500
           ++L  T  IV++ FT+ +LG +  PL+  +D++     R NKK   +S+
Sbjct: 445 RQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKAHRRNKKDVNLSK 493


>gi|5454070 solute carrier family 9 (sodium/hydrogen exchanger),
           member 6 isoform b [Homo sapiens]
          Length = 669

 Score =  199 bits (507), Expect = 7e-51
 Identities = 145/505 (28%), Positives = 250/505 (49%), Gaps = 48/505 (9%)

Query: 77  HVQIPFEITLWILLASLAKIGFHLY-HKLPTIVPESCLLIMVGLLLGGII-FGVD----- 129
           H Q    + ++ILL +L  +   L+ H+    + E+ L ++ GLL+G ++ +G+      
Sbjct: 67  HRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDV 126

Query: 130 ---------EKSPPAMKT----DVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVG 176
                    + SP  +      +VFF  LLPPI+  AGY +  R FF N+G+I  YA +G
Sbjct: 127 NNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLG 186

Query: 177 TLWNSIGIGVSLFG---ICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNE 233
           T  +   IG  ++G   + ++      D      LLFG+++SA DPV VLA+F  + V+ 
Sbjct: 187 TAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDV 246

Query: 234 QLYILVFGESLLNDAVTVVLYNLFKSF----CQMKTIETIDVFAGIANFFVVGIGGVLIG 289
           +LY L+FGES+LNDAV +VL +   ++        T +   +F  I  F  +  G   +G
Sbjct: 247 ELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMG 306

Query: 290 IFLGFIAAFTTRFT--HNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYV 347
              G + A  T+FT     +++E    FL S+ +++ AE +  +G++A+  C +T   Y 
Sbjct: 307 AATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYT 366

Query: 348 EENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVST-VGKNHEWNWAFVCFTLAFCLMWRA 406
             N+S +S    K   ++L+ ++E  IF +MG++    +NH +N  FV        + RA
Sbjct: 367 YNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRA 426

Query: 407 LGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIV 466
             ++ L+ ++N  R   +    Q ++ + GLRGA+ FAL  +   A + R+ +F T  ++
Sbjct: 427 ANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALA-IRDTATYARQMMFST-TLL 484

Query: 467 VIFFTVFILGITIRPLVEFLDVK---RSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGH 523
           ++FFTV++ G     ++  L ++    S+++   V E       +   T  E     W  
Sbjct: 485 IVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPEN------ERRTTKAESA---WLF 535

Query: 524 NFWRDKFKKFDDKYLRKLLIRENQP 548
             W +    FD  YL+ LL     P
Sbjct: 536 RMWYN----FDHNYLKPLLTHSGPP 556


>gi|27734935 solute carrier family 9 (sodium/hydrogen exchanger),
           member 9 [Homo sapiens]
          Length = 645

 Score =  199 bits (507), Expect = 7e-51
 Identities = 133/425 (31%), Positives = 214/425 (50%), Gaps = 24/425 (5%)

Query: 139 DVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQ--IEA 196
           ++FF  LLPPI+  AGY +  R FF+N+G+I  YA +GT  + I IG+ ++G  +  I A
Sbjct: 132 EIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHA 191

Query: 197 FGLS--DITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLY 254
             L   D      L FGSL+SA DPV VLA+F  +HV+  LY L+FGES+LNDAV +VL 
Sbjct: 192 GQLKNGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLT 251

Query: 255 NLFKSFCQMKTIETIDV---FAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTH--NIRVI 309
                +   +     D    F  + NF  +  G   +G     I A  T+FT      ++
Sbjct: 252 YSISIYSPKENPNAFDAAAFFQSVGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPML 311

Query: 310 EPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSV 369
           E    FL S+ ++++AE   L+GI+A+  C +T   Y   N+S  S    K   + ++ +
Sbjct: 312 ETGLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFL 371

Query: 370 SETLIFIFMGVST-VGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKD 428
           +E +IF +MG++    +NH +N  F+        + RA  ++ L+ ++N  R   + +  
Sbjct: 372 AENVIFCYMGLALFTFQNHIFNALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNF 431

Query: 429 QFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDV 488
           Q ++ + GLRGAI FAL   +       K++  T  ++++FFTV++ G    P++ +L +
Sbjct: 432 QHMMMFSGLRGAIAFALA--IRNTESQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQI 489

Query: 489 K-----RSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLI 543
           +       N K+   S+       D   T  E          +R  +  FD KYL+ +L 
Sbjct: 490 RVGVDLDENLKEDPSSQHQEANNLDKNMTKAESA------RLFR-MWYSFDHKYLKPILT 542

Query: 544 RENQP 548
               P
Sbjct: 543 HSGPP 547


>gi|110227626 solute carrier family 9 (sodium/hydrogen exchanger),
           member 6 isoform a [Homo sapiens]
          Length = 701

 Score =  192 bits (488), Expect = 1e-48
 Identities = 128/423 (30%), Positives = 215/423 (50%), Gaps = 28/423 (6%)

Query: 139 DVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFG---ICQIE 195
           +VFF  LLPPI+  AGY +  R FF N+G+I  YA +GT  +   IG  ++G   + ++ 
Sbjct: 181 EVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVT 240

Query: 196 AFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYN 255
                D      LLFG+++SA DPV VLA+F  + V+ +LY L+FGES+LNDAV +VL +
Sbjct: 241 GQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSS 300

Query: 256 LFKSF----CQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFT--HNIRVI 309
              ++        T +   +F  I  F  +  G   +G   G + A  T+FT     +++
Sbjct: 301 SIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLL 360

Query: 310 EPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSV 369
           E    FL S+ +++ AE +  +G++A+  C +T   Y   N+S +S    K   ++L+ +
Sbjct: 361 ETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFL 420

Query: 370 SETLIFIFMGVST-VGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKD 428
           +E  IF +MG++    +NH +N  FV        + RA  ++ L+ ++N  R   +    
Sbjct: 421 AENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNF 480

Query: 429 QFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDV 488
           Q ++ + GLRGA+ FAL  +   A + R+ +F T  ++++FFTV++ G     ++  L +
Sbjct: 481 QHMMMFAGLRGAMAFALA-IRDTATYARQMMFST-TLLIVFFTVWVFGGGTTAMLSCLHI 538

Query: 489 K---RSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRE 545
           +    S+++   V E       +   T  E     W    W +    FD  YL+ LL   
Sbjct: 539 RVGVDSDQEHLGVPEN------ERRTTKAESA---WLFRMWYN----FDHNYLKPLLTHS 585

Query: 546 NQP 548
             P
Sbjct: 586 GPP 588


>gi|14211919 solute carrier family 9, member 7 [Homo sapiens]
          Length = 725

 Score =  181 bits (458), Expect = 3e-45
 Identities = 114/361 (31%), Positives = 196/361 (54%), Gaps = 13/361 (3%)

Query: 139 DVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAF- 197
           +VFF  LLPPI+  AGY +  R FF N+G+I  YA +GT  +   IG  ++G+ ++    
Sbjct: 181 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM 240

Query: 198 -GLSDITLLQN-LLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYN 255
             LSD     + L FG++ISA DPV VLA+F  +H +  LY L+FGES+LNDAV +VL +
Sbjct: 241 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS 300

Query: 256 LFKSF----CQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFT--HNIRVI 309
              ++          +    F  +  F  +  G   +G   G + A  T+FT  H   ++
Sbjct: 301 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTG-VNANVTKFTKLHCFPLL 359

Query: 310 EPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSV 369
           E    FL S+ +++ AE    +G++A+  C +T   Y   N+S +S +  K   ++L  +
Sbjct: 360 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL 419

Query: 370 SETLIFIFMGVST-VGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKD 428
           +E  IF +MG++    + H ++  F+        + RA  ++ L+  +N  R   + +  
Sbjct: 420 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF 479

Query: 429 QFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDV 488
           Q ++ + GLRGA+ FAL  +   A + R+ +F T  ++++FFTV+I+G    P++ +L++
Sbjct: 480 QHMMMFSGLRGAMAFALA-IRDTASYARQMMF-TTTLLIVFFTVWIIGGGTTPMLSWLNI 537

Query: 489 K 489
           +
Sbjct: 538 R 538


>gi|56786136 sperm-specific sodium proton exchanger [Homo sapiens]
          Length = 1177

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 75/350 (21%), Positives = 147/350 (42%), Gaps = 35/350 (10%)

Query: 88  ILLASLAKIGFHLYHKLPTI-VPESCLLIMVGLLLGGIIFGVDEKSPPA-----MKTDVF 141
           + L+ ++ IG  L   L    +P   +L ++G     + F   +    A     M  D+F
Sbjct: 20  LTLSLISSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLSFTSSQVQRYANAIQWMSPDLF 79

Query: 142 FLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSD 201
           F    P +     + M T    +    I   ++ G L N I +   L  + Q+       
Sbjct: 80  FRIFTPVVFFTTAFDMDTYMLQKLFWQILLISIPGFLVNYILVLWHLASVNQLL------ 133

Query: 202 ITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSF- 260
           +   Q LLF +++ + DP+   A   ++ ++  L  L+ GESL+   ++++ +     F 
Sbjct: 134 LKPTQWLLFSAILVSSDPMLTAAAIRDLGLSRSLISLINGESLMTSVISLITFTSIMDFD 193

Query: 261 --CQMKTIETI--DVFAGIANFFVVGIGGVLIGIFLGFIAAF--TTRFTHNIRVIEPLFV 314
              Q K   T+  ++  GI ++    I   L GI    +  F  +T F  ++  I  +F 
Sbjct: 194 QRLQSKRNHTLAEEIVGGICSYI---IASFLFGILSSKLIQFWMSTVFGDDVNHISLIFS 250

Query: 315 FLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLI 374
            L  YL +   E+  +SGI  +    + +N    +   ++  T +  F   LS ++  ++
Sbjct: 251 IL--YLIFYICELVGMSGIFTLAIVGLLLNSTSFKAAIEE--TLLLEFWTFLSRIAFLMV 306

Query: 375 FIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPL 424
           F F G+      + +        + F  ++ +L ++ LT ++ RF T+ L
Sbjct: 307 FTFFGLLIPAHTYLY--------IEFVDIYYSLNIY-LTLIVLRFLTLLL 347


>gi|224465231 solute carrier family 9, member 11 [Homo sapiens]
          Length = 1124

 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 69/330 (20%), Positives = 132/330 (40%), Gaps = 41/330 (12%)

Query: 110 ESCLLIMVGLL-LGGIIFG--------VDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTR 160
           ++C +I++ +L L G + G        V +   P ++T  F LY          YF P  
Sbjct: 50  KNCEVIVLTILSLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLY---------SYFSPLI 100

Query: 161 PFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEA------FGLSDITLLQNLLFGSLI 214
            F   +   F Y +    W  +  G+  F    I        F      L   LLF   +
Sbjct: 101 IFMVALDVEF-YTLKKMFWQVLLTGLISFSTASIIIGYVVIKFNKDSWDLQSCLLFSITL 159

Query: 215 SAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAG 274
             +DP+  +   + I +++    L+ GESL+  ++  + +  F+      +I   D+  G
Sbjct: 160 GIIDPLRSVNSLKTIGISKIYIDLIRGESLIICSIASIFFGNFRGNRIHFSIFR-DLHVG 218

Query: 275 IANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIM 334
           I   + + +G ++ G +   I         +  +   +  F   Y+++   E   +SG +
Sbjct: 219 IELSYDI-LGSIIFGYWCAKIIQCILADVFSNMLTNIILCFSMVYMTFYIVEFLGMSGTL 277

Query: 335 AITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFV 394
           A+ A  + ++         K    I  F+++ SSV E LI+ F G+  +G     ++ F 
Sbjct: 278 ALAAVGLNLDSL---TFKPKIELVITKFLRIFSSVYEHLIYAFFGI-VIGCGELSHYEF- 332

Query: 395 CFTLAFCLMWRALGVFVLTQVINRFRTIPL 424
             T+ F        +F+L   +N  R + +
Sbjct: 333 -HTIPF--------IFILFTTVNLVRLLTI 353


>gi|50843827 activating molecule in beclin-1-regulated autophagy
           [Homo sapiens]
          Length = 1208

 Score = 38.5 bits (88), Expect = 0.025
 Identities = 30/117 (25%), Positives = 50/117 (42%), Gaps = 13/117 (11%)

Query: 653 SLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRAR 712
           S+ R+    +  S Y S  +    P         + +DG +  S  ++G+    LQ   R
Sbjct: 359 SVLRQQEGGSQASVYTSATEGRGFPAS----GLATESDGGNGSSQNNSGSIRHELQCDLR 414

Query: 713 RF---------LPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTS 760
           RF         L +  S ++PQ+ + +     +++S R  PS  PTPHS E  +  S
Sbjct: 415 RFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLS 471


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 35.4 bits (80), Expect = 0.21
 Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 5/66 (7%)

Query: 743 MPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSL--TEGIP-PKPPPRLVWRA-- 797
           +P  PP P   E G QT    +  L+   +  S + DS   T+ I  P PPP L+W A  
Sbjct: 763 LPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQ 822

Query: 798 SEPGSR 803
            +PGS+
Sbjct: 823 GQPGSQ 828


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 35.0 bits (79), Expect = 0.28
 Identities = 46/210 (21%), Positives = 80/210 (38%), Gaps = 24/210 (11%)

Query: 606 SRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTS 665
           S+++  + Q    Y+  S T   S++    +L      L+ S  +DS   +      S+S
Sbjct: 392 SQHVSSVTQNQKQYDTSSKTHSNSQQGTSSML---EDDLQLSDSEDSDSEQTPEKPPSSS 448

Query: 666 RYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQ 725
              S P++  LPE +    + S    ++SDSD+ + +   +    +    P +     P+
Sbjct: 449 APPSAPQS--LPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPE 506

Query: 726 ---SYKMEWKNEVDVDSGRDMP------STPPTPHSREKGTQTSGLLQQPLLSKDQSGSE 776
              + K +  N +   S    P      + PP  H   KG+  S   Q+   SKD     
Sbjct: 507 PPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKS 566

Query: 777 REDSLTEGIPPKPPPRLVWRASEPGSRKAR 806
              +      P+ PP     A  PG R  +
Sbjct: 567 SSKA------PRAPP----EAPHPGKRSCQ 586


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 34.7 bits (78), Expect = 0.36
 Identities = 53/230 (23%), Positives = 85/230 (36%), Gaps = 21/230 (9%)

Query: 589 KIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESI 648
           KIR V        R   SR+    R R+ S  RHS  + +    +K       HS   S 
Sbjct: 169 KIRLVEDKPGSRRRRSYSRSRSHSRSRSRS--RHSRKSRSRSGSSKS-----SHSKSRSR 221

Query: 649 RKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNL- 707
            +  S +R    S S SR  S  + ++ P K + R     A  + S S   A   + N  
Sbjct: 222 SRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNND 281

Query: 708 ---QPRAR---RFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSG 761
              +P++R   R   +  S+   Q  ++E +    V  GR    +     SR +    S 
Sbjct: 282 NVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGS- 340

Query: 762 LLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEK 811
                  S+ +S S+ +D        +   R   R+     R  + GS++
Sbjct: 341 ------RSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKR 384


>gi|4557719 DNA ligase I [Homo sapiens]
          Length = 919

 Score = 34.3 bits (77), Expect = 0.48
 Identities = 30/123 (24%), Positives = 51/123 (41%), Gaps = 14/123 (11%)

Query: 670 LPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKM 729
           +PK     ++L KR    + +  S D D +A         R +    E+  K+S    + 
Sbjct: 118 IPKRRTARKQLPKRTIQEVLEEQSEDEDREA--------KRKKEEEEEETPKESLT--EA 167

Query: 730 EWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKP 789
           E   E + + G D P+TPP P    K    +  + +P ++  Q   E E+      PP+ 
Sbjct: 168 EVATEKEGEDG-DQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTK---PPRR 223

Query: 790 PPR 792
            P+
Sbjct: 224 APK 226


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score = 33.9 bits (76), Expect = 0.62
 Identities = 40/178 (22%), Positives = 73/178 (41%), Gaps = 21/178 (11%)

Query: 638 IRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSD 697
           + R+HSL++S +++      H  +   + +     N KLP+ + K++  + A+G   D  
Sbjct: 368 LERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAEGVQEDPP 427

Query: 698 ADAGTTVLNLQP-RARRFLPEQFSKKSPQSYKMEWKNEVD-------VDSGRDMPSTPPT 749
                + +   P +A   LP++   K P+  +  + +  +       +D+G    S  P 
Sbjct: 428 E---LSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDP- 483

Query: 750 PHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPK-------PPPRLVWRASEP 800
               +K  Q SGLL         +G   + +L    P          PPR + RAS P
Sbjct: 484 --KEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRP 539


>gi|161169017 neuron navigator 2 isoform 4 [Homo sapiens]
          Length = 1493

 Score = 33.9 bits (76), Expect = 0.62
 Identities = 53/241 (21%), Positives = 94/241 (39%), Gaps = 40/241 (16%)

Query: 562 KHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNR 621
           +   E      +S V + +S+    EEK +    SE  ++R  L  +  ++   T     
Sbjct: 669 RDGFEEVHGSSLSLVSSTSSVYSTPEEKCQ----SEIRKLRRELDASQEKVSALTTQLTA 724

Query: 622 HSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHR-----------ASTSTSRYLSL 670
           ++      E+    + IR +     + +KDS LN   +           A  + +  ++ 
Sbjct: 725 NAHLVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINT 784

Query: 671 PK------NTKLPEKLQKRR---TISIADGNSSDSDADAGTTVLNLQPRARR--FLPEQF 719
           P+       T     L+ RR   + S++  NS+ S +  G+ + +   + +R  +L   F
Sbjct: 785 PELNCKGNGTAQSADLRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNWLRSSF 844

Query: 720 S-----KKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSG 774
                 KKSP+S       E   DS   +PS+P  PH+   G+        PLL    S 
Sbjct: 845 KQAFGKKKSPKSASSHSDIEEMTDSS--LPSSPKLPHNGSTGS-------TPLLRNSHSN 895

Query: 775 S 775
           S
Sbjct: 896 S 896


>gi|161169015 neuron navigator 2 isoform 3 [Homo sapiens]
          Length = 2365

 Score = 33.9 bits (76), Expect = 0.62
 Identities = 53/241 (21%), Positives = 94/241 (39%), Gaps = 40/241 (16%)

Query: 562  KHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNR 621
            +   E      +S V + +S+    EEK +    SE  ++R  L  +  ++   T     
Sbjct: 1541 RDGFEEVHGSSLSLVSSTSSVYSTPEEKCQ----SEIRKLRRELDASQEKVSALTTQLTA 1596

Query: 622  HSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHR-----------ASTSTSRYLSL 670
            ++      E+    + IR +     + +KDS LN   +           A  + +  ++ 
Sbjct: 1597 NAHLVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINT 1656

Query: 671  PK------NTKLPEKLQKRR---TISIADGNSSDSDADAGTTVLNLQPRARR--FLPEQF 719
            P+       T     L+ RR   + S++  NS+ S +  G+ + +   + +R  +L   F
Sbjct: 1657 PELNCKGNGTAQSADLRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNWLRSSF 1716

Query: 720  S-----KKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSG 774
                  KKSP+S       E   DS   +PS+P  PH+   G+        PLL    S 
Sbjct: 1717 KQAFGKKKSPKSASSHSDIEEMTDSS--LPSSPKLPHNGSTGS-------TPLLRNSHSN 1767

Query: 775  S 775
            S
Sbjct: 1768 S 1768


>gi|38044282 neuron navigator 2 isoform 2 [Homo sapiens]
          Length = 2429

 Score = 33.9 bits (76), Expect = 0.62
 Identities = 53/241 (21%), Positives = 94/241 (39%), Gaps = 40/241 (16%)

Query: 562  KHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNR 621
            +   E      +S V + +S+    EEK +    SE  ++R  L  +  ++   T     
Sbjct: 1605 RDGFEEVHGSSLSLVSSTSSVYSTPEEKCQ----SEIRKLRRELDASQEKVSALTTQLTA 1660

Query: 622  HSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHR-----------ASTSTSRYLSL 670
            ++      E+    + IR +     + +KDS LN   +           A  + +  ++ 
Sbjct: 1661 NAHLVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINT 1720

Query: 671  PK------NTKLPEKLQKRR---TISIADGNSSDSDADAGTTVLNLQPRARR--FLPEQF 719
            P+       T     L+ RR   + S++  NS+ S +  G+ + +   + +R  +L   F
Sbjct: 1721 PELNCKGNGTAQSADLRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNWLRSSF 1780

Query: 720  S-----KKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSG 774
                  KKSP+S       E   DS   +PS+P  PH+   G+        PLL    S 
Sbjct: 1781 KQAFGKKKSPKSASSHSDIEEMTDSS--LPSSPKLPHNGSTGS-------TPLLRNSHSN 1831

Query: 775  S 775
            S
Sbjct: 1832 S 1832


>gi|116812577 LUC7-like 2 [Homo sapiens]
          Length = 392

 Score = 33.9 bits (76), Expect = 0.62
 Identities = 41/182 (22%), Positives = 72/182 (39%), Gaps = 13/182 (7%)

Query: 600 EIRELLSRNLYQIRQRTLSYNRHSLTA-DTSERQAKEILIRRRHSLRESIRKDSSLNREH 658
           EIRE L      + ++    N+  L   +  ER+ +E L R R   +   R  S  +R H
Sbjct: 220 EIREKLEELKRVVAEKQEKRNQERLKRREEREREEREKLRRSRSHSKNPKRSRSREHRRH 279

Query: 659 RASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQ 718
           R S S SR       +K  EK  + R+ S +   S        ++    + R++R     
Sbjct: 280 R-SRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRSRHSSRDRSRERSKR----- 333

Query: 719 FSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSERE 778
                 +S K  ++++      RD  S   +P  R++  +          S+D+  SE  
Sbjct: 334 ------RSSKERFRDQDLASCDRDRSSRDRSPRDRDRKDKKRSYESANGRSEDRRSSEER 387

Query: 779 DS 780
           ++
Sbjct: 388 EA 389


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score = 33.5 bits (75), Expect = 0.81
 Identities = 29/90 (32%), Positives = 42/90 (46%), Gaps = 8/90 (8%)

Query: 711 ARRFLPEQFSKKSPQSYK-MEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLS 769
           ++RFL    +   P   K  EW++   V   RD+ ST     S   G   S   ++P L 
Sbjct: 710 SKRFLRSCSASCVPHGAKDTEWRS---VTLPRDLQSTGRQFDSSTFGGHKS---EKPALP 763

Query: 770 KDQSGSEREDSLTEGIPPKPPPRLVWRASE 799
           + ++G  R D +T G    PPPRLV +  E
Sbjct: 764 RKRAGENRSDQVTRG-TVTPPPRLVKKNEE 792


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score = 33.5 bits (75), Expect = 0.81
 Identities = 29/90 (32%), Positives = 42/90 (46%), Gaps = 8/90 (8%)

Query: 711 ARRFLPEQFSKKSPQSYK-MEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLS 769
           ++RFL    +   P   K  EW++   V   RD+ ST     S   G   S   ++P L 
Sbjct: 729 SKRFLRSCSASCVPHGAKDTEWRS---VTLPRDLQSTGRQFDSSTFGGHKS---EKPALP 782

Query: 770 KDQSGSEREDSLTEGIPPKPPPRLVWRASE 799
           + ++G  R D +T G    PPPRLV +  E
Sbjct: 783 RKRAGENRSDQVTRG-TVTPPPRLVKKNEE 811


>gi|93204867 G protein-coupled receptor 158 [Homo sapiens]
          Length = 1215

 Score = 33.5 bits (75), Expect = 0.81
 Identities = 38/164 (23%), Positives = 66/164 (40%), Gaps = 18/164 (10%)

Query: 545 ENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIREL 604
           EN    S+       ++K   E   T  +  V   AS ++   EK  K     T  +++ 
Sbjct: 845 ENSTLESLSGKKLTQKLKEDSEAESTESVPLVCKSASAHNLSSEK--KTGHPRTSMLQKS 902

Query: 605 LSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTST 664
           LS  +   +++TL     + TA   ER   +          + + KD   NR H  S +T
Sbjct: 903 LSV-IASAKEKTLGLAGKTQTAGVEERTKSQ----------KPLPKDKETNRNHSNSDNT 951

Query: 665 SRYLSLPKNTKLPEKLQKRRTISI-----ADGNSSDSDADAGTT 703
                 P+N+   E+ +K +   I      +  +++SD + GTT
Sbjct: 952 ETKDPAPQNSNPAEEPRKPQKSGIMKQQRVNPTTANSDLNPGTT 995


>gi|112421108 capicua homolog [Homo sapiens]
          Length = 1608

 Score = 33.5 bits (75), Expect = 0.81
 Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 6/64 (9%)

Query: 726  SYKMEWKNEVDVDSGRDMPSTPP------TPHSREKGTQTSGLLQQPLLSKDQSGSERED 779
            SY+ + KN  D+DS  + P++P       +  S E  T  S   +  + + D++G+E ED
Sbjct: 1389 SYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTEAED 1448

Query: 780  SLTE 783
             L E
Sbjct: 1449 VLGE 1452


>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo
           sapiens]
          Length = 1341

 Score = 33.1 bits (74), Expect = 1.1
 Identities = 27/140 (19%), Positives = 60/140 (42%), Gaps = 5/140 (3%)

Query: 645 RESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNS-SDSDADAGTT 703
           R S RK SS++ E   S          K  +   ++++ R   +++G+  ++ + D  T 
Sbjct: 200 RHSPRKSSSISEEKGDSDDEKPR----KGERRSSRVRQARAAKLSEGSQPAEEEEDQETP 255

Query: 704 VLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLL 763
             NL+ RA R L  +  ++  +  + + + E   D G+     P     +E+G +   + 
Sbjct: 256 SRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVK 315

Query: 764 QQPLLSKDQSGSEREDSLTE 783
            + ++ +      +E  + E
Sbjct: 316 PEEMMDERPKTRSQEQEVLE 335


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 33.1 bits (74), Expect = 1.1
 Identities = 46/231 (19%), Positives = 85/231 (36%), Gaps = 17/231 (7%)

Query: 563 HAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRH 622
           HA+E+  +    T PT    N     +++   S E  EI+    R   Q +QR     R 
Sbjct: 106 HALEVLNSQ--ETGPTLPRQNSQLPAQVQNGPSQEELEIQ----RRQLQEQQRQKELERE 159

Query: 623 SLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQK 682
            L  +  ER+  E     R  L     +   L RE +      R L   +  +  E+L++
Sbjct: 160 RLERERMERERLERERLERERLERERLEQEQLERERQERERQER-LERQERLERQERLER 218

Query: 683 RRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRD 742
           +  +        + +            R  R   E+  ++  +  ++EW+ E  + S   
Sbjct: 219 QERLDRERQERQERER---------LERLERERQERERQEQLEREQLEWERERRISSAA- 268

Query: 743 MPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRL 793
            P++  TP +   G  ++        S+      ++  +   + P PPP L
Sbjct: 269 APASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPL 319


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 33.1 bits (74), Expect = 1.1
 Identities = 46/231 (19%), Positives = 85/231 (36%), Gaps = 17/231 (7%)

Query: 563 HAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRH 622
           HA+E+  +    T PT    N     +++   S E  EI+    R   Q +QR     R 
Sbjct: 106 HALEVLNSQ--ETGPTLPRQNSQLPAQVQNGPSQEELEIQ----RRQLQEQQRQKELERE 159

Query: 623 SLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQK 682
            L  +  ER+  E     R  L     +   L RE +      R L   +  +  E+L++
Sbjct: 160 RLERERMERERLERERLERERLERERLEQEQLERERQERERQER-LERQERLERQERLER 218

Query: 683 RRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRD 742
           +  +        + +            R  R   E+  ++  +  ++EW+ E  + S   
Sbjct: 219 QERLDRERQERQERER---------LERLERERQERERQEQLEREQLEWERERRISSAA- 268

Query: 743 MPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRL 793
            P++  TP +   G  ++        S+      ++  +   + P PPP L
Sbjct: 269 APASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPL 319


>gi|56847634 hypothetical protein LOC441294 [Homo sapiens]
          Length = 777

 Score = 33.1 bits (74), Expect = 1.1
 Identities = 27/118 (22%), Positives = 53/118 (44%), Gaps = 8/118 (6%)

Query: 530 FKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEK 589
           F+  + K  +KL I     + + + LY+KL ++    + E   +S V    S    + E 
Sbjct: 373 FESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLET 432

Query: 590 IRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHS----LTADTSERQAKEILIRRRHS 643
            RK+      ++ E L R ++  +++ +SY +      L A T+ER   ++     H+
Sbjct: 433 YRKLAK----DLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHN 486


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,743,050
Number of Sequences: 37866
Number of extensions: 1359031
Number of successful extensions: 5574
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 5488
Number of HSP's gapped (non-prelim): 121
length of query: 812
length of database: 18,247,518
effective HSP length: 111
effective length of query: 701
effective length of database: 14,044,392
effective search space: 9845118792
effective search space used: 9845118792
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.