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Search of human proteins with 154689847
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154689847 hypothetical protein LOC9851 [Homo sapiens]
(967 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154689847 hypothetical protein LOC9851 [Homo sapiens] 1920 0.0
gi|71061468 centromere protein E [Homo sapiens] 59 2e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 54 5e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 54 5e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 54 5e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 54 5e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 54 5e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 54 5e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 54 5e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 54 5e-07
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 51 5e-06
gi|21735548 centrosomal protein 2 [Homo sapiens] 51 6e-06
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 50 8e-06
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 49 3e-05
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 48 4e-05
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 48 5e-05
gi|11067749 bromodomain containing protein 3 [Homo sapiens] 45 4e-04
gi|4504063 golgin 97 [Homo sapiens] 44 6e-04
gi|45439327 periplakin [Homo sapiens] 44 0.001
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 43 0.002
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 42 0.002
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 42 0.002
gi|156104874 envoplakin [Homo sapiens] 42 0.002
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 42 0.003
gi|118498362 kinectin 1 isoform b [Homo sapiens] 41 0.005
gi|55770834 centromere protein F [Homo sapiens] 41 0.005
gi|8923271 coiled-coil domain containing 49 [Homo sapiens] 41 0.005
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 41 0.006
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 41 0.006
gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens] 40 0.008
>gi|154689847 hypothetical protein LOC9851 [Homo sapiens]
Length = 967
Score = 1920 bits (4975), Expect = 0.0
Identities = 967/967 (100%), Positives = 967/967 (100%)
Query: 1 MGPGQPASTCVHLAPRTQLDGRSDPKVLQTQNQLQFNRNVPTHSSNLAIRYSCPHAIRIE 60
MGPGQPASTCVHLAPRTQLDGRSDPKVLQTQNQLQFNRNVPTHSSNLAIRYSCPHAIRIE
Sbjct: 1 MGPGQPASTCVHLAPRTQLDGRSDPKVLQTQNQLQFNRNVPTHSSNLAIRYSCPHAIRIE 60
Query: 61 KLKHSYNESYHCKDADCRVGPDLGSSVSFSVISQERLSYAVHLARRDVKRRQFEKHIKEH 120
KLKHSYNESYHCKDADCRVGPDLGSSVSFSVISQERLSYAVHLARRDVKRRQFEKHIKEH
Sbjct: 61 KLKHSYNESYHCKDADCRVGPDLGSSVSFSVISQERLSYAVHLARRDVKRRQFEKHIKEH 120
Query: 121 HLRSQPQSSQKCGHTKYKIPDHRVERKESKSQAACQCSHQPSKVEISSSGAKVYLYSSHP 180
HLRSQPQSSQKCGHTKYKIPDHRVERKESKSQAACQCSHQPSKVEISSSGAKVYLYSSHP
Sbjct: 121 HLRSQPQSSQKCGHTKYKIPDHRVERKESKSQAACQCSHQPSKVEISSSGAKVYLYSSHP 180
Query: 181 GQSDLTVPNSPPTHDPGLQPHPRIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKD 240
GQSDLTVPNSPPTHDPGLQPHPRIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKD
Sbjct: 181 GQSDLTVPNSPPTHDPGLQPHPRIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKD 240
Query: 241 RLEEALDPDEERRIRIRRQEQAARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAM 300
RLEEALDPDEERRIRIRRQEQAARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAM
Sbjct: 241 RLEEALDPDEERRIRIRRQEQAARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAM 300
Query: 301 SKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVV 360
SKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVV
Sbjct: 301 SKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVV 360
Query: 361 IDILQQIEALESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAK 420
IDILQQIEALESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAK
Sbjct: 361 IDILQQIEALESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAK 420
Query: 421 DTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFK 480
DTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFK
Sbjct: 421 DTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFK 480
Query: 481 DEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVS 540
DEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVS
Sbjct: 481 DEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVS 540
Query: 541 SRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHL 600
SRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHL
Sbjct: 541 SRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHL 600
Query: 601 TGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKA 660
TGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKA
Sbjct: 601 TGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKA 660
Query: 661 EEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQ 720
EEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQ
Sbjct: 661 EEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQ 720
Query: 721 PAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMR 780
PAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMR
Sbjct: 721 PAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMR 780
Query: 781 RMEEMEKYQESVRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHPIRITKTVDRKD 840
RMEEMEKYQESVRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHPIRITKTVDRKD
Sbjct: 781 RMEEMEKYQESVRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHPIRITKTVDRKD 840
Query: 841 PAVNIMLERPCNGNSLDESVGTEEGSEKREAPLLSLAEDSQQKEGRAPLFVPPGMQHSIG 900
PAVNIMLERPCNGNSLDESVGTEEGSEKREAPLLSLAEDSQQKEGRAPLFVPPGMQHSIG
Sbjct: 841 PAVNIMLERPCNGNSLDESVGTEEGSEKREAPLLSLAEDSQQKEGRAPLFVPPGMQHSIG 900
Query: 901 DYCSRFEQYLRIISHEAVGSFNPWLIAESFSEELVDEALGAVAAELQDMCEDYAEAVFTS 960
DYCSRFEQYLRIISHEAVGSFNPWLIAESFSEELVDEALGAVAAELQDMCEDYAEAVFTS
Sbjct: 901 DYCSRFEQYLRIISHEAVGSFNPWLIAESFSEELVDEALGAVAAELQDMCEDYAEAVFTS 960
Query: 961 EFLEAAT 967
EFLEAAT
Sbjct: 961 EFLEAAT 967
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 59.3 bits (142), Expect = 2e-08
Identities = 132/687 (19%), Positives = 282/687 (41%), Gaps = 88/687 (12%)
Query: 204 IGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAA 263
+ D++ I +Q+ + + + + EL + + + +K++L+ D E + I QE+
Sbjct: 1033 VKDNEIIEQQRKIFSLIQEKNELQQMLESV--IAEKEQLKT--DLKENIEMTIENQEE-- 1086
Query: 264 RSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTD 323
L +L ++K+ QE + + H IK K +S+ L+ Q +
Sbjct: 1087 -----LRLLGDELKKQQEIVAQEKNHAIK---KEGELSRTCDRLAEVEEKLKEKSQQLQE 1138
Query: 324 RGEHPLPAR--CKELGSLIRQLSLCSVKL-DADPSVPDVVIDILQQIEALESLLEKKLSP 380
+ + L + E+ I ++ +L + + ++ + + L+ + L E+ S
Sbjct: 1139 KQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSI 1198
Query: 381 KKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADK 440
K +K E++ F +G R + A T Q +A L +
Sbjct: 1199 TKERKVLKELQKSFETERDHL---------RGYIREIEA--TGLQTKEELKIAHIHLKEH 1247
Query: 441 YQPDTEL-----PETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKA--GK 493
+ EL +T ++ + D+ + L+E +L + V V++T+ +
Sbjct: 1248 QETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE 1307
Query: 494 KKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQT----TVSSRLKMNRQP 549
+ +TE + TLA + LR E+ ++SQ KS ++ T+ L++
Sbjct: 1308 LELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQ 1367
Query: 550 VKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAA 609
+K+ + S + L +K + TK + E + + +E E
Sbjct: 1368 LKEHIRETLAKIQESQSKQEQS---LNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424
Query: 610 RLAWLDAETSKRLKEL-EELK--AKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRL 666
L SKRL+E +E+K AKE D +Q+ + + L +E+ + + + E+ A+ +
Sbjct: 1425 GL-------SKRLQESHDEMKSVAKEKDDLQRLQ-EVLQSESDQLKENIKEIVAKHLETE 1476
Query: 667 QQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVA 726
++L V+ H K +E ++ L+ L + + ST + + ++N QE+
Sbjct: 1477 EELKVA--HCCLKEQEETINELRVNLSEKETEISTIQKQLE-----AINDKLQNKIQEIY 1529
Query: 727 AVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDS---------KDSPDLEI 777
+ E NI+Q+ + +++ +EL + L ++E + +++I
Sbjct: 1530 EKE-EQFNIKQISE-VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
Query: 778 MMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHPIRITKTVD 837
M++ EEM++ QE+++ +++ +EN + ++ + E +
Sbjct: 1588 MIKEKEEMKRVQEALQIERDQL----------KENTKEIVAKMKESQEKEYQF------- 1630
Query: 838 RKDPAVNIMLERPCNGNSLDESVGTEE 864
K AVN E+ C L E T++
Sbjct: 1631 LKMTAVNETQEKMCEIEHLKEQFETQK 1657
Score = 43.1 bits (100), Expect = 0.001
Identities = 61/277 (22%), Positives = 108/277 (38%), Gaps = 40/277 (14%)
Query: 586 KEPLQQEDPQEESHLTGAVEHEAAR---LAWLDAETSKRLKELEELKAKEIDSMQK---- 638
K+ L E +ES + G +E LA + +E + K +D QK
Sbjct: 777 KDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMV 836
Query: 639 --------QRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKP 690
Q + L E + L LK E Y+ Q+L + +++ E +++LK
Sbjct: 837 LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNE--MEQLKE 894
Query: 691 LLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDCASELW 750
L T E ++ + + Q +EV + E ++++QL + L+ +L
Sbjct: 895 QLENRDSTLQTVE-----REKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLK 949
Query: 751 AVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQE 810
+ H TV + D+ E + +E ++++QE++ +KI+ R E
Sbjct: 950 SDIHD---------TVNMNIDTQ--EQLRNALESLKQHQETINTLKSKISEEVSRNLHME 998
Query: 811 ENN-------DQKISAISEKPLSPHPIRITKTVDRKD 840
EN QK+ I +K T T D KD
Sbjct: 999 ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKD 1035
Score = 32.0 bits (71), Expect = 2.9
Identities = 38/181 (20%), Positives = 80/181 (44%), Gaps = 22/181 (12%)
Query: 617 ETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHL 676
ET +L+ + K EI +MQK D E S + +LK +E R+ H+
Sbjct: 1735 ETIDKLRGIVSEKTNEISNMQK------DLEHSNDALKAQDLKIQEELRI-------AHM 1781
Query: 677 ADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIR 736
K ++ +D+L+ ++ + T + + KD + N + QE+ A + + ++
Sbjct: 1782 HLKEQQETIDKLRGIVSE-----KTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836
Query: 737 QLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRY 796
+ + + SE+ + S TL+ +E +L + + E +E+ + +++R
Sbjct: 1837 KDVNETQKKVSEMEQLKKQIKDQSLTLSKLE----IENLNLAQKLHENLEEMKSVMKERD 1892
Query: 797 N 797
N
Sbjct: 1893 N 1893
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 54.3 bits (129), Expect = 5e-07
Identities = 147/730 (20%), Positives = 284/730 (38%), Gaps = 131/730 (17%)
Query: 203 RIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQA 262
R+ + + ++EQ+ E +RL E+ + + K ++ + +A E + ++ R QE+
Sbjct: 1343 RMEEEERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 263 ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIR--------AL 314
R QQQ + IQEEL +L + + + AA R +R L
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 315 QMFVTQFTDRGE----HPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEAL 370
Q+ T+ G L AR +E + RQ ++ E L
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--------------------EEAERL 1499
Query: 371 ESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRP 430
++ + K+ + E+ SR ++ A E+ + E R L A++
Sbjct: 1500 RRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELR-LQAEE--------- 1547
Query: 431 SVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTK 490
A++ E+ +++Q L+ E + + ASF + KT
Sbjct: 1548 -------AERRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAE------KTA 1590
Query: 491 AGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQ-QTTVSSRLKMNRQP 549
++ E+V + A R Q +AER R+ R Q + + RL++ +
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 550 VKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAA 609
V +K+ + +A K Q+E+ + E+ G E +A
Sbjct: 1651 VAQQKS-----------------------LAQAEAEK---QKEEAEREARRRGKAEEQAV 1684
Query: 610 RLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQL 669
R L + ++ ++L E A++ +Q L L AET + ++ +L EE+ RLQ+
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQGEQQ-RQLLEEELARLQRE 1742
Query: 670 SVSATHLADKVE---EAVLDRLKPLLVKAQRV----NSTTEANIHLKDGSSVNTAK-AQP 721
+ +AT ++E V ++ LL R ST+E + + + + A+
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 722 AQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEI---- 777
A + A+ E+ RQL + ED A + ++L + A E ++ + EI
Sbjct: 1803 AARLRALAEEAKRQRQLAE--EDAARQ--RAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 778 ------MMRRMEEMEKYQES--VRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHP 829
+RR+ E E +Q Q A + RL + +D ++ +K L
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE--RQKGLVEDT 1916
Query: 830 IRITKTVDRKDPAVNIMLERPCNG------------NSLDESVGTEEGSEKREAPLLSLA 877
+R + V+ + A+ E+ G ++ ++++ ++E +E A LA
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 878 EDSQQKEGRA 887
+ +++ A
Sbjct: 1977 AEEERRRREA 1986
Score = 45.1 bits (105), Expect = 3e-04
Identities = 136/742 (18%), Positives = 281/742 (37%), Gaps = 126/742 (16%)
Query: 213 QKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVL 272
QKSL + ++ + + ++E + K ++EEA RR+R R ++++AR ++
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERL--KAKVEEA------RRLRERAEQESARQLQLAQEA 2042
Query: 273 QQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPAR 332
Q+ + +E+ H +K + + + + L RGE R
Sbjct: 2043 AQKRLQAEEKA-----HAFAVQQKEQELQQTLQQEQSVLDQL---------RGEAEAARR 2088
Query: 333 CKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI-----EALESLLEKKLSPKKVKKCF 387
E R V+ + + + ++ +++ E ++ + + + +K++K
Sbjct: 2089 AAEEAEEAR------VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 388 SEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQ----ETSRPSVAKQLLADKYQP 443
+ +R Q AL + + + E+ A+ T Q E ++ QL +Q
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202
Query: 444 DTELPETQRLQSE------------------------LDVLDADIVLEEGPFILDQSASF 479
+ E QRL++E L L A I E IL
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---- 2258
Query: 480 KDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQ---SQPHSKSRVQQ 536
KD + +A K K V E AR + L + + +Q ++ K ++Q
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 537 TTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQE 596
++RLK + ++ +K A + + D KE + Q+ +E
Sbjct: 2319 VQEATRLKAEAELLQQQKE----------------LAQEQARRLQED--KEQMAQQLAEE 2360
Query: 597 ESHLTGAVEHEAARLAWLDAETSK---RLKELEELKAKEIDSMQKQRLDWLD-AETSRRT 652
+E E R + AE + R+ E+ +A+ + Q+ R + E RT
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Query: 653 KELNELKAEEMYRLQQLSVSATHLADKVEEAV--LDRLKPLLVKAQRVNSTTEANIHLKD 710
+ + K + L+ + H A+++ EA+ L+R K L + ++ + LK
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-------LQLKS 2473
Query: 711 GSSVNTAKAQPAQEVAAVD----FESNNIRQLDDFLEDCASELWAVTHAKILGSETL--- 763
+ Q QE A+ E +++ Q + F+E ++L + ++ ++ L
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533
Query: 764 ----------------ATVEDSK--DSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
A++E+++ E + R+ EE+++ ++ RQ+ +A + R
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 806 L--WMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTE 863
L +Q + + + ++ + TKT+ A++ +S D
Sbjct: 2594 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653
Query: 864 EGSEKREAPLLSLAEDSQQKEG 885
+EA +LS E + +G
Sbjct: 2654 SAQRLQEAGILSAEELQRLAQG 2675
Score = 43.5 bits (101), Expect = 0.001
Identities = 135/634 (21%), Positives = 259/634 (40%), Gaps = 83/634 (13%)
Query: 218 EVQRLQKELSSCIH---KIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQ 274
E++R Q + + + + EEV ++ L +A + E++ +E+A R AR ++
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQA---EAEKQ-----KEEAEREARRRGKAEE 1681
Query: 275 QVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCK 334
Q Q EL + K + + A +LAA IR + T++GE +
Sbjct: 1682 QAVR-QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIR-----LRAETEQGEQQRQLLEE 1734
Query: 335 ELGSLIRQLSLCSVK---LDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIR 391
EL L R+ + + K L+A+ + +++L +A + S K ++ +E
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA- 1793
Query: 392 SRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQ 451
RF +++A +R L +D Q A+++LA+K + E
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKL---AAIGEAT 1846
Query: 452 RLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDT--- 508
RL++E A+I L+E + + + +A+ +A +++ + E K D
Sbjct: 1847 RLKTE-----AEIALKE-------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 509 LAPARQQGLRKAERGR---QSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPW------IP 559
LA R+ + ER + + + +V++ ++ LK + + KA I
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEKAAAGKAELELELGRIR 1952
Query: 560 PNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETS 619
N S K A L+ + A +E ++ + +E + A E EAAR +
Sbjct: 1953 SNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR------QRK 2005
Query: 620 KRLKELEELKAKEIDSMQ-KQRLDWLDAETSRRTKEL--NELKAEE---MYRLQQLSVSA 673
L+E+E LKAK ++ + ++R + A + +E L+AEE + +QQ
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 674 THLADKVEEAVLDRLKPLLVKAQR-VNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFES 732
+ E++VLD+L+ A+R EA + A+ + AQ V+ E+
Sbjct: 2066 QQTLQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQ---------AEREAAQSRRQVE-EA 2114
Query: 733 NNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESV 792
++Q + ++ A +E A + L EMEK+++
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 793 RQRYNKIAYADPRLW---MQEENNDQKISAISEK 823
Q + A + L +Q E D + + + E+
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Score = 40.0 bits (92), Expect = 0.011
Identities = 104/491 (21%), Positives = 191/491 (38%), Gaps = 106/491 (21%)
Query: 207 HKNISEQKSLLEVQRLQKELSSCIHKIEEVT-KKDRLEEALDPDEERRIRIRRQEQAARS 265
HK +EQ +L + ++++EL++ ++EE +K+ L+E L R + +A +
Sbjct: 2170 HKKFAEQ-TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ---------RLKAEATEA 2219
Query: 266 ARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRG 325
AR +++++ ++ ++++LS KL A RAL + T R
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELS--------------KLKARIEAENRALILRDKDNTQRF 2265
Query: 326 EHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKK 385
+ K++ +LS+ + + + + D+ QQ E +L++K+ +
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEKMLKEKMQAVQ--- 2320
Query: 386 CFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDT 445
+T K E L + QE +R +L DK Q
Sbjct: 2321 --------------------EATRLKAEAELLQQQKELAQEQAR-----RLQEDKEQMAQ 2355
Query: 446 ELPE-TQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFR 504
+L E TQ Q L+ E L+ SA + L VA+ + + + FR
Sbjct: 2356 QLAEETQGFQRTLEA--------ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407
Query: 505 KK----------------------DTLAPARQQGLRKAERGRQS---QPHSKSRVQQTTV 539
K+ TL RQQ AER R++ K ++QQ
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467
Query: 540 SSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQED--PQEE 597
+LK ++ + A + S +D+ LQ+E QE+
Sbjct: 2468 LLQLKSEEMQTVQQEQ-----------LLQETQALQQSFLSEKDSL---LQRERFIEQEK 2513
Query: 598 SHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNE 657
+ L + E A+ L E ++ +++E+ + + + SM++ R +AE R K+ E
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ-EE 2572
Query: 658 LKAEEMYRLQQ 668
L+ E R QQ
Sbjct: 2573 LQQLEQQRRQQ 2583
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 54.3 bits (129), Expect = 5e-07
Identities = 147/730 (20%), Positives = 284/730 (38%), Gaps = 131/730 (17%)
Query: 203 RIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQA 262
R+ + + ++EQ+ E +RL E+ + + K ++ + +A E + ++ R QE+
Sbjct: 1347 RMEEEERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405
Query: 263 ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIR--------AL 314
R QQQ + IQEEL +L + + + AA R +R L
Sbjct: 1406 VRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1463
Query: 315 QMFVTQFTDRGE----HPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEAL 370
Q+ T+ G L AR +E + RQ ++ E L
Sbjct: 1464 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--------------------EEAERL 1503
Query: 371 ESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRP 430
++ + K+ + E+ SR ++ A E+ + E R L A++
Sbjct: 1504 RRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELR-LQAEE--------- 1551
Query: 431 SVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTK 490
A++ E+ +++Q L+ E + + ASF + KT
Sbjct: 1552 -------AERRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAE------KTA 1594
Query: 491 AGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQ-QTTVSSRLKMNRQP 549
++ E+V + A R Q +AER R+ R Q + + RL++ +
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654
Query: 550 VKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAA 609
V +K+ + +A K Q+E+ + E+ G E +A
Sbjct: 1655 VAQQKS-----------------------LAQAEAEK---QKEEAEREARRRGKAEEQAV 1688
Query: 610 RLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQL 669
R L + ++ ++L E A++ +Q L L AET + ++ +L EE+ RLQ+
Sbjct: 1689 RQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQGEQQ-RQLLEEELARLQRE 1746
Query: 670 SVSATHLADKVE---EAVLDRLKPLLVKAQRV----NSTTEANIHLKDGSSVNTAK-AQP 721
+ +AT ++E V ++ LL R ST+E + + + + A+
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806
Query: 722 AQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEI---- 777
A + A+ E+ RQL + ED A + ++L + A E ++ + EI
Sbjct: 1807 AARLRALAEEAKRQRQLAE--EDAARQ--RAEAERVLAEKLAAIGEATRLKTEAEIALKE 1862
Query: 778 ------MMRRMEEMEKYQES--VRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHP 829
+RR+ E E +Q Q A + RL + +D ++ +K L
Sbjct: 1863 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE--RQKGLVEDT 1920
Query: 830 IRITKTVDRKDPAVNIMLERPCNG------------NSLDESVGTEEGSEKREAPLLSLA 877
+R + V+ + A+ E+ G ++ ++++ ++E +E A LA
Sbjct: 1921 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1980
Query: 878 EDSQQKEGRA 887
+ +++ A
Sbjct: 1981 AEEERRRREA 1990
Score = 45.1 bits (105), Expect = 3e-04
Identities = 136/742 (18%), Positives = 281/742 (37%), Gaps = 126/742 (16%)
Query: 213 QKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVL 272
QKSL + ++ + + ++E + K ++EEA RR+R R ++++AR ++
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERL--KAKVEEA------RRLRERAEQESARQLQLAQEA 2046
Query: 273 QQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPAR 332
Q+ + +E+ H +K + + + + L RGE R
Sbjct: 2047 AQKRLQAEEKA-----HAFAVQQKEQELQQTLQQEQSVLDQL---------RGEAEAARR 2092
Query: 333 CKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI-----EALESLLEKKLSPKKVKKCF 387
E R V+ + + + ++ +++ E ++ + + + +K++K
Sbjct: 2093 AAEEAEEAR------VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2146
Query: 388 SEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQ----ETSRPSVAKQLLADKYQP 443
+ +R Q AL + + + E+ A+ T Q E ++ QL +Q
Sbjct: 2147 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2206
Query: 444 DTELPETQRLQSE------------------------LDVLDADIVLEEGPFILDQSASF 479
+ E QRL++E L L A I E IL
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---- 2262
Query: 480 KDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQ---SQPHSKSRVQQ 536
KD + +A K K V E AR + L + + +Q ++ K ++Q
Sbjct: 2263 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2322
Query: 537 TTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQE 596
++RLK + ++ +K A + + D KE + Q+ +E
Sbjct: 2323 VQEATRLKAEAELLQQQKE----------------LAQEQARRLQED--KEQMAQQLAEE 2364
Query: 597 ESHLTGAVEHEAARLAWLDAETSK---RLKELEELKAKEIDSMQKQRLDWLD-AETSRRT 652
+E E R + AE + R+ E+ +A+ + Q+ R + E RT
Sbjct: 2365 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2424
Query: 653 KELNELKAEEMYRLQQLSVSATHLADKVEEAV--LDRLKPLLVKAQRVNSTTEANIHLKD 710
+ + K + L+ + H A+++ EA+ L+R K L + ++ + LK
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-------LQLKS 2477
Query: 711 GSSVNTAKAQPAQEVAAVD----FESNNIRQLDDFLEDCASELWAVTHAKILGSETL--- 763
+ Q QE A+ E +++ Q + F+E ++L + ++ ++ L
Sbjct: 2478 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2537
Query: 764 ----------------ATVEDSK--DSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
A++E+++ E + R+ EE+++ ++ RQ+ +A + R
Sbjct: 2538 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2597
Query: 806 L--WMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTE 863
L +Q + + + ++ + TKT+ A++ +S D
Sbjct: 2598 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2657
Query: 864 EGSEKREAPLLSLAEDSQQKEG 885
+EA +LS E + +G
Sbjct: 2658 SAQRLQEAGILSAEELQRLAQG 2679
Score = 43.5 bits (101), Expect = 0.001
Identities = 135/634 (21%), Positives = 259/634 (40%), Gaps = 83/634 (13%)
Query: 218 EVQRLQKELSSCIH---KIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQ 274
E++R Q + + + + EEV ++ L +A + E++ +E+A R AR ++
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQA---EAEKQ-----KEEAEREARRRGKAEE 1685
Query: 275 QVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCK 334
Q Q EL + K + + A +LAA IR + T++GE +
Sbjct: 1686 QAVR-QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIR-----LRAETEQGEQQRQLLEE 1738
Query: 335 ELGSLIRQLSLCSVK---LDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIR 391
EL L R+ + + K L+A+ + +++L +A + S K ++ +E
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA- 1797
Query: 392 SRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQ 451
RF +++A +R L +D Q A+++LA+K + E
Sbjct: 1798 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKL---AAIGEAT 1850
Query: 452 RLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDT--- 508
RL++E A+I L+E + + + +A+ +A +++ + E K D
Sbjct: 1851 RLKTE-----AEIALKE-------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898
Query: 509 LAPARQQGLRKAERGR---QSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPW------IP 559
LA R+ + ER + + + +V++ ++ LK + + KA I
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEKAAAGKAELELELGRIR 1956
Query: 560 PNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETS 619
N S K A L+ + A +E ++ + +E + A E EAAR +
Sbjct: 1957 SNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR------QRK 2009
Query: 620 KRLKELEELKAKEIDSMQ-KQRLDWLDAETSRRTKEL--NELKAEE---MYRLQQLSVSA 673
L+E+E LKAK ++ + ++R + A + +E L+AEE + +QQ
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2069
Query: 674 THLADKVEEAVLDRLKPLLVKAQR-VNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFES 732
+ E++VLD+L+ A+R EA + A+ + AQ V+ E+
Sbjct: 2070 QQTLQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQ---------AEREAAQSRRQVE-EA 2118
Query: 733 NNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESV 792
++Q + ++ A +E A + L EMEK+++
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2178
Query: 793 RQRYNKIAYADPRLW---MQEENNDQKISAISEK 823
Q + A + L +Q E D + + + E+
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212
Score = 40.0 bits (92), Expect = 0.011
Identities = 104/491 (21%), Positives = 191/491 (38%), Gaps = 106/491 (21%)
Query: 207 HKNISEQKSLLEVQRLQKELSSCIHKIEEVT-KKDRLEEALDPDEERRIRIRRQEQAARS 265
HK +EQ +L + ++++EL++ ++EE +K+ L+E L R + +A +
Sbjct: 2174 HKKFAEQ-TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ---------RLKAEATEA 2223
Query: 266 ARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRG 325
AR +++++ ++ ++++LS KL A RAL + T R
Sbjct: 2224 ARQRSQVEEELFSVRVQMEELS--------------KLKARIEAENRALILRDKDNTQRF 2269
Query: 326 EHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKK 385
+ K++ +LS+ + + + + D+ QQ E +L++K+ +
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEKMLKEKMQAVQ--- 2324
Query: 386 CFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDT 445
+T K E L + QE +R +L DK Q
Sbjct: 2325 --------------------EATRLKAEAELLQQQKELAQEQAR-----RLQEDKEQMAQ 2359
Query: 446 ELPE-TQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFR 504
+L E TQ Q L+ E L+ SA + L VA+ + + + FR
Sbjct: 2360 QLAEETQGFQRTLEA--------ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2411
Query: 505 KK----------------------DTLAPARQQGLRKAERGRQS---QPHSKSRVQQTTV 539
K+ TL RQQ AER R++ K ++QQ
Sbjct: 2412 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2471
Query: 540 SSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQED--PQEE 597
+LK ++ + A + S +D+ LQ+E QE+
Sbjct: 2472 LLQLKSEEMQTVQQEQ-----------LLQETQALQQSFLSEKDSL---LQRERFIEQEK 2517
Query: 598 SHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNE 657
+ L + E A+ L E ++ +++E+ + + + SM++ R +AE R K+ E
Sbjct: 2518 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ-EE 2576
Query: 658 LKAEEMYRLQQ 668
L+ E R QQ
Sbjct: 2577 LQQLEQQRRQQ 2587
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 54.3 bits (129), Expect = 5e-07
Identities = 147/730 (20%), Positives = 284/730 (38%), Gaps = 131/730 (17%)
Query: 203 RIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQA 262
R+ + + ++EQ+ E +RL E+ + + K ++ + +A E + ++ R QE+
Sbjct: 1343 RMEEEERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 263 ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIR--------AL 314
R QQQ + IQEEL +L + + + AA R +R L
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 315 QMFVTQFTDRGE----HPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEAL 370
Q+ T+ G L AR +E + RQ ++ E L
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--------------------EEAERL 1499
Query: 371 ESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRP 430
++ + K+ + E+ SR ++ A E+ + E R L A++
Sbjct: 1500 RRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELR-LQAEE--------- 1547
Query: 431 SVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTK 490
A++ E+ +++Q L+ E + + ASF + KT
Sbjct: 1548 -------AERRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAE------KTA 1590
Query: 491 AGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQ-QTTVSSRLKMNRQP 549
++ E+V + A R Q +AER R+ R Q + + RL++ +
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 550 VKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAA 609
V +K+ + +A K Q+E+ + E+ G E +A
Sbjct: 1651 VAQQKS-----------------------LAQAEAEK---QKEEAEREARRRGKAEEQAV 1684
Query: 610 RLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQL 669
R L + ++ ++L E A++ +Q L L AET + ++ +L EE+ RLQ+
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQGEQQ-RQLLEEELARLQRE 1742
Query: 670 SVSATHLADKVE---EAVLDRLKPLLVKAQRV----NSTTEANIHLKDGSSVNTAK-AQP 721
+ +AT ++E V ++ LL R ST+E + + + + A+
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 722 AQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEI---- 777
A + A+ E+ RQL + ED A + ++L + A E ++ + EI
Sbjct: 1803 AARLRALAEEAKRQRQLAE--EDAARQ--RAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 778 ------MMRRMEEMEKYQES--VRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHP 829
+RR+ E E +Q Q A + RL + +D ++ +K L
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE--RQKGLVEDT 1916
Query: 830 IRITKTVDRKDPAVNIMLERPCNG------------NSLDESVGTEEGSEKREAPLLSLA 877
+R + V+ + A+ E+ G ++ ++++ ++E +E A LA
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 878 EDSQQKEGRA 887
+ +++ A
Sbjct: 1977 AEEERRRREA 1986
Score = 45.1 bits (105), Expect = 3e-04
Identities = 136/742 (18%), Positives = 281/742 (37%), Gaps = 126/742 (16%)
Query: 213 QKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVL 272
QKSL + ++ + + ++E + K ++EEA RR+R R ++++AR ++
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERL--KAKVEEA------RRLRERAEQESARQLQLAQEA 2042
Query: 273 QQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPAR 332
Q+ + +E+ H +K + + + + L RGE R
Sbjct: 2043 AQKRLQAEEKA-----HAFAVQQKEQELQQTLQQEQSVLDQL---------RGEAEAARR 2088
Query: 333 CKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI-----EALESLLEKKLSPKKVKKCF 387
E R V+ + + + ++ +++ E ++ + + + +K++K
Sbjct: 2089 AAEEAEEAR------VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 388 SEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQ----ETSRPSVAKQLLADKYQP 443
+ +R Q AL + + + E+ A+ T Q E ++ QL +Q
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202
Query: 444 DTELPETQRLQSE------------------------LDVLDADIVLEEGPFILDQSASF 479
+ E QRL++E L L A I E IL
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---- 2258
Query: 480 KDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQ---SQPHSKSRVQQ 536
KD + +A K K V E AR + L + + +Q ++ K ++Q
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 537 TTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQE 596
++RLK + ++ +K A + + D KE + Q+ +E
Sbjct: 2319 VQEATRLKAEAELLQQQKE----------------LAQEQARRLQED--KEQMAQQLAEE 2360
Query: 597 ESHLTGAVEHEAARLAWLDAETSK---RLKELEELKAKEIDSMQKQRLDWLD-AETSRRT 652
+E E R + AE + R+ E+ +A+ + Q+ R + E RT
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Query: 653 KELNELKAEEMYRLQQLSVSATHLADKVEEAV--LDRLKPLLVKAQRVNSTTEANIHLKD 710
+ + K + L+ + H A+++ EA+ L+R K L + ++ + LK
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-------LQLKS 2473
Query: 711 GSSVNTAKAQPAQEVAAVD----FESNNIRQLDDFLEDCASELWAVTHAKILGSETL--- 763
+ Q QE A+ E +++ Q + F+E ++L + ++ ++ L
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533
Query: 764 ----------------ATVEDSK--DSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
A++E+++ E + R+ EE+++ ++ RQ+ +A + R
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 806 L--WMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTE 863
L +Q + + + ++ + TKT+ A++ +S D
Sbjct: 2594 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653
Query: 864 EGSEKREAPLLSLAEDSQQKEG 885
+EA +LS E + +G
Sbjct: 2654 SAQRLQEAGILSAEELQRLAQG 2675
Score = 43.5 bits (101), Expect = 0.001
Identities = 135/634 (21%), Positives = 259/634 (40%), Gaps = 83/634 (13%)
Query: 218 EVQRLQKELSSCIH---KIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQ 274
E++R Q + + + + EEV ++ L +A + E++ +E+A R AR ++
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQA---EAEKQ-----KEEAEREARRRGKAEE 1681
Query: 275 QVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCK 334
Q Q EL + K + + A +LAA IR + T++GE +
Sbjct: 1682 QAVR-QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIR-----LRAETEQGEQQRQLLEE 1734
Query: 335 ELGSLIRQLSLCSVK---LDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIR 391
EL L R+ + + K L+A+ + +++L +A + S K ++ +E
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA- 1793
Query: 392 SRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQ 451
RF +++A +R L +D Q A+++LA+K + E
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKL---AAIGEAT 1846
Query: 452 RLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDT--- 508
RL++E A+I L+E + + + +A+ +A +++ + E K D
Sbjct: 1847 RLKTE-----AEIALKE-------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 509 LAPARQQGLRKAERGR---QSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPW------IP 559
LA R+ + ER + + + +V++ ++ LK + + KA I
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEKAAAGKAELELELGRIR 1952
Query: 560 PNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETS 619
N S K A L+ + A +E ++ + +E + A E EAAR +
Sbjct: 1953 SNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR------QRK 2005
Query: 620 KRLKELEELKAKEIDSMQ-KQRLDWLDAETSRRTKEL--NELKAEE---MYRLQQLSVSA 673
L+E+E LKAK ++ + ++R + A + +E L+AEE + +QQ
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 674 THLADKVEEAVLDRLKPLLVKAQR-VNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFES 732
+ E++VLD+L+ A+R EA + A+ + AQ V+ E+
Sbjct: 2066 QQTLQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQ---------AEREAAQSRRQVE-EA 2114
Query: 733 NNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESV 792
++Q + ++ A +E A + L EMEK+++
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 793 RQRYNKIAYADPRLW---MQEENNDQKISAISEK 823
Q + A + L +Q E D + + + E+
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Score = 40.0 bits (92), Expect = 0.011
Identities = 104/491 (21%), Positives = 191/491 (38%), Gaps = 106/491 (21%)
Query: 207 HKNISEQKSLLEVQRLQKELSSCIHKIEEVT-KKDRLEEALDPDEERRIRIRRQEQAARS 265
HK +EQ +L + ++++EL++ ++EE +K+ L+E L R + +A +
Sbjct: 2170 HKKFAEQ-TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ---------RLKAEATEA 2219
Query: 266 ARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRG 325
AR +++++ ++ ++++LS KL A RAL + T R
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELS--------------KLKARIEAENRALILRDKDNTQRF 2265
Query: 326 EHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKK 385
+ K++ +LS+ + + + + D+ QQ E +L++K+ +
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEKMLKEKMQAVQ--- 2320
Query: 386 CFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDT 445
+T K E L + QE +R +L DK Q
Sbjct: 2321 --------------------EATRLKAEAELLQQQKELAQEQAR-----RLQEDKEQMAQ 2355
Query: 446 ELPE-TQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFR 504
+L E TQ Q L+ E L+ SA + L VA+ + + + FR
Sbjct: 2356 QLAEETQGFQRTLEA--------ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407
Query: 505 KK----------------------DTLAPARQQGLRKAERGRQS---QPHSKSRVQQTTV 539
K+ TL RQQ AER R++ K ++QQ
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467
Query: 540 SSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQED--PQEE 597
+LK ++ + A + S +D+ LQ+E QE+
Sbjct: 2468 LLQLKSEEMQTVQQEQ-----------LLQETQALQQSFLSEKDSL---LQRERFIEQEK 2513
Query: 598 SHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNE 657
+ L + E A+ L E ++ +++E+ + + + SM++ R +AE R K+ E
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ-EE 2572
Query: 658 LKAEEMYRLQQ 668
L+ E R QQ
Sbjct: 2573 LQQLEQQRRQQ 2583
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 54.3 bits (129), Expect = 5e-07
Identities = 147/730 (20%), Positives = 284/730 (38%), Gaps = 131/730 (17%)
Query: 203 RIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQA 262
R+ + + ++EQ+ E +RL E+ + + K ++ + +A E + ++ R QE+
Sbjct: 1311 RMEEEERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 263 ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIR--------AL 314
R QQQ + IQEEL +L + + + AA R +R L
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1427
Query: 315 QMFVTQFTDRGE----HPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEAL 370
Q+ T+ G L AR +E + RQ ++ E L
Sbjct: 1428 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--------------------EEAERL 1467
Query: 371 ESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRP 430
++ + K+ + E+ SR ++ A E+ + E R L A++
Sbjct: 1468 RRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELR-LQAEE--------- 1515
Query: 431 SVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTK 490
A++ E+ +++Q L+ E + + ASF + KT
Sbjct: 1516 -------AERRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAE------KTA 1558
Query: 491 AGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQ-QTTVSSRLKMNRQP 549
++ E+V + A R Q +AER R+ R Q + + RL++ +
Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618
Query: 550 VKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAA 609
V +K+ + +A K Q+E+ + E+ G E +A
Sbjct: 1619 VAQQKS-----------------------LAQAEAEK---QKEEAEREARRRGKAEEQAV 1652
Query: 610 RLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQL 669
R L + ++ ++L E A++ +Q L L AET + ++ +L EE+ RLQ+
Sbjct: 1653 RQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQGEQQ-RQLLEEELARLQRE 1710
Query: 670 SVSATHLADKVE---EAVLDRLKPLLVKAQRV----NSTTEANIHLKDGSSVNTAK-AQP 721
+ +AT ++E V ++ LL R ST+E + + + + A+
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770
Query: 722 AQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEI---- 777
A + A+ E+ RQL + ED A + ++L + A E ++ + EI
Sbjct: 1771 AARLRALAEEAKRQRQLAE--EDAARQ--RAEAERVLAEKLAAIGEATRLKTEAEIALKE 1826
Query: 778 ------MMRRMEEMEKYQES--VRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHP 829
+RR+ E E +Q Q A + RL + +D ++ +K L
Sbjct: 1827 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE--RQKGLVEDT 1884
Query: 830 IRITKTVDRKDPAVNIMLERPCNG------------NSLDESVGTEEGSEKREAPLLSLA 877
+R + V+ + A+ E+ G ++ ++++ ++E +E A LA
Sbjct: 1885 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1944
Query: 878 EDSQQKEGRA 887
+ +++ A
Sbjct: 1945 AEEERRRREA 1954
Score = 45.1 bits (105), Expect = 3e-04
Identities = 136/742 (18%), Positives = 281/742 (37%), Gaps = 126/742 (16%)
Query: 213 QKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVL 272
QKSL + ++ + + ++E + K ++EEA RR+R R ++++AR ++
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERL--KAKVEEA------RRLRERAEQESARQLQLAQEA 2010
Query: 273 QQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPAR 332
Q+ + +E+ H +K + + + + L RGE R
Sbjct: 2011 AQKRLQAEEKA-----HAFAVQQKEQELQQTLQQEQSVLDQL---------RGEAEAARR 2056
Query: 333 CKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI-----EALESLLEKKLSPKKVKKCF 387
E R V+ + + + ++ +++ E ++ + + + +K++K
Sbjct: 2057 AAEEAEEAR------VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2110
Query: 388 SEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQ----ETSRPSVAKQLLADKYQP 443
+ +R Q AL + + + E+ A+ T Q E ++ QL +Q
Sbjct: 2111 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2170
Query: 444 DTELPETQRLQSE------------------------LDVLDADIVLEEGPFILDQSASF 479
+ E QRL++E L L A I E IL
Sbjct: 2171 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---- 2226
Query: 480 KDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQ---SQPHSKSRVQQ 536
KD + +A K K V E AR + L + + +Q ++ K ++Q
Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2286
Query: 537 TTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQE 596
++RLK + ++ +K A + + D KE + Q+ +E
Sbjct: 2287 VQEATRLKAEAELLQQQKE----------------LAQEQARRLQED--KEQMAQQLAEE 2328
Query: 597 ESHLTGAVEHEAARLAWLDAETSK---RLKELEELKAKEIDSMQKQRLDWLD-AETSRRT 652
+E E R + AE + R+ E+ +A+ + Q+ R + E RT
Sbjct: 2329 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2388
Query: 653 KELNELKAEEMYRLQQLSVSATHLADKVEEAV--LDRLKPLLVKAQRVNSTTEANIHLKD 710
+ + K + L+ + H A+++ EA+ L+R K L + ++ + LK
Sbjct: 2389 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-------LQLKS 2441
Query: 711 GSSVNTAKAQPAQEVAAVD----FESNNIRQLDDFLEDCASELWAVTHAKILGSETL--- 763
+ Q QE A+ E +++ Q + F+E ++L + ++ ++ L
Sbjct: 2442 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2501
Query: 764 ----------------ATVEDSK--DSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
A++E+++ E + R+ EE+++ ++ RQ+ +A + R
Sbjct: 2502 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2561
Query: 806 L--WMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTE 863
L +Q + + + ++ + TKT+ A++ +S D
Sbjct: 2562 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2621
Query: 864 EGSEKREAPLLSLAEDSQQKEG 885
+EA +LS E + +G
Sbjct: 2622 SAQRLQEAGILSAEELQRLAQG 2643
Score = 43.5 bits (101), Expect = 0.001
Identities = 135/634 (21%), Positives = 259/634 (40%), Gaps = 83/634 (13%)
Query: 218 EVQRLQKELSSCIH---KIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQ 274
E++R Q + + + + EEV ++ L +A + E++ +E+A R AR ++
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQA---EAEKQ-----KEEAEREARRRGKAEE 1649
Query: 275 QVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCK 334
Q Q EL + K + + A +LAA IR + T++GE +
Sbjct: 1650 QAVR-QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIR-----LRAETEQGEQQRQLLEE 1702
Query: 335 ELGSLIRQLSLCSVK---LDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIR 391
EL L R+ + + K L+A+ + +++L +A + S K ++ +E
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA- 1761
Query: 392 SRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQ 451
RF +++A +R L +D Q A+++LA+K + E
Sbjct: 1762 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKL---AAIGEAT 1814
Query: 452 RLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDT--- 508
RL++E A+I L+E + + + +A+ +A +++ + E K D
Sbjct: 1815 RLKTE-----AEIALKE-------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862
Query: 509 LAPARQQGLRKAERGR---QSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPW------IP 559
LA R+ + ER + + + +V++ ++ LK + + KA I
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEKAAAGKAELELELGRIR 1920
Query: 560 PNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETS 619
N S K A L+ + A +E ++ + +E + A E EAAR +
Sbjct: 1921 SNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR------QRK 1973
Query: 620 KRLKELEELKAKEIDSMQ-KQRLDWLDAETSRRTKEL--NELKAEE---MYRLQQLSVSA 673
L+E+E LKAK ++ + ++R + A + +E L+AEE + +QQ
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2033
Query: 674 THLADKVEEAVLDRLKPLLVKAQR-VNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFES 732
+ E++VLD+L+ A+R EA + A+ + AQ V+ E+
Sbjct: 2034 QQTLQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQ---------AEREAAQSRRQVE-EA 2082
Query: 733 NNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESV 792
++Q + ++ A +E A + L EMEK+++
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2142
Query: 793 RQRYNKIAYADPRLW---MQEENNDQKISAISEK 823
Q + A + L +Q E D + + + E+
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176
Score = 40.0 bits (92), Expect = 0.011
Identities = 104/491 (21%), Positives = 191/491 (38%), Gaps = 106/491 (21%)
Query: 207 HKNISEQKSLLEVQRLQKELSSCIHKIEEVT-KKDRLEEALDPDEERRIRIRRQEQAARS 265
HK +EQ +L + ++++EL++ ++EE +K+ L+E L R + +A +
Sbjct: 2138 HKKFAEQ-TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ---------RLKAEATEA 2187
Query: 266 ARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRG 325
AR +++++ ++ ++++LS KL A RAL + T R
Sbjct: 2188 ARQRSQVEEELFSVRVQMEELS--------------KLKARIEAENRALILRDKDNTQRF 2233
Query: 326 EHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKK 385
+ K++ +LS+ + + + + D+ QQ E +L++K+ +
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEKMLKEKMQAVQ--- 2288
Query: 386 CFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDT 445
+T K E L + QE +R +L DK Q
Sbjct: 2289 --------------------EATRLKAEAELLQQQKELAQEQAR-----RLQEDKEQMAQ 2323
Query: 446 ELPE-TQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFR 504
+L E TQ Q L+ E L+ SA + L VA+ + + + FR
Sbjct: 2324 QLAEETQGFQRTLEA--------ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2375
Query: 505 KK----------------------DTLAPARQQGLRKAERGRQS---QPHSKSRVQQTTV 539
K+ TL RQQ AER R++ K ++QQ
Sbjct: 2376 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2435
Query: 540 SSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQED--PQEE 597
+LK ++ + A + S +D+ LQ+E QE+
Sbjct: 2436 LLQLKSEEMQTVQQEQ-----------LLQETQALQQSFLSEKDSL---LQRERFIEQEK 2481
Query: 598 SHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNE 657
+ L + E A+ L E ++ +++E+ + + + SM++ R +AE R K+ E
Sbjct: 2482 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ-EE 2540
Query: 658 LKAEEMYRLQQ 668
L+ E R QQ
Sbjct: 2541 LQQLEQQRRQQ 2551
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 54.3 bits (129), Expect = 5e-07
Identities = 147/730 (20%), Positives = 284/730 (38%), Gaps = 131/730 (17%)
Query: 203 RIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQA 262
R+ + + ++EQ+ E +RL E+ + + K ++ + +A E + ++ R QE+
Sbjct: 1480 RMEEEERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538
Query: 263 ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIR--------AL 314
R QQQ + IQEEL +L + + + AA R +R L
Sbjct: 1539 VRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1596
Query: 315 QMFVTQFTDRGE----HPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEAL 370
Q+ T+ G L AR +E + RQ ++ E L
Sbjct: 1597 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--------------------EEAERL 1636
Query: 371 ESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRP 430
++ + K+ + E+ SR ++ A E+ + E R L A++
Sbjct: 1637 RRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELR-LQAEE--------- 1684
Query: 431 SVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTK 490
A++ E+ +++Q L+ E + + ASF + KT
Sbjct: 1685 -------AERRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAE------KTA 1727
Query: 491 AGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQ-QTTVSSRLKMNRQP 549
++ E+V + A R Q +AER R+ R Q + + RL++ +
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787
Query: 550 VKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAA 609
V +K+ + +A K Q+E+ + E+ G E +A
Sbjct: 1788 VAQQKS-----------------------LAQAEAEK---QKEEAEREARRRGKAEEQAV 1821
Query: 610 RLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQL 669
R L + ++ ++L E A++ +Q L L AET + ++ +L EE+ RLQ+
Sbjct: 1822 RQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQGEQQ-RQLLEEELARLQRE 1879
Query: 670 SVSATHLADKVE---EAVLDRLKPLLVKAQRV----NSTTEANIHLKDGSSVNTAK-AQP 721
+ +AT ++E V ++ LL R ST+E + + + + A+
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939
Query: 722 AQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEI---- 777
A + A+ E+ RQL + ED A + ++L + A E ++ + EI
Sbjct: 1940 AARLRALAEEAKRQRQLAE--EDAARQ--RAEAERVLAEKLAAIGEATRLKTEAEIALKE 1995
Query: 778 ------MMRRMEEMEKYQES--VRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHP 829
+RR+ E E +Q Q A + RL + +D ++ +K L
Sbjct: 1996 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE--RQKGLVEDT 2053
Query: 830 IRITKTVDRKDPAVNIMLERPCNG------------NSLDESVGTEEGSEKREAPLLSLA 877
+R + V+ + A+ E+ G ++ ++++ ++E +E A LA
Sbjct: 2054 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2113
Query: 878 EDSQQKEGRA 887
+ +++ A
Sbjct: 2114 AEEERRRREA 2123
Score = 45.1 bits (105), Expect = 3e-04
Identities = 136/742 (18%), Positives = 281/742 (37%), Gaps = 126/742 (16%)
Query: 213 QKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVL 272
QKSL + ++ + + ++E + K ++EEA RR+R R ++++AR ++
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERL--KAKVEEA------RRLRERAEQESARQLQLAQEA 2179
Query: 273 QQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPAR 332
Q+ + +E+ H +K + + + + L RGE R
Sbjct: 2180 AQKRLQAEEKA-----HAFAVQQKEQELQQTLQQEQSVLDQL---------RGEAEAARR 2225
Query: 333 CKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI-----EALESLLEKKLSPKKVKKCF 387
E R V+ + + + ++ +++ E ++ + + + +K++K
Sbjct: 2226 AAEEAEEAR------VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2279
Query: 388 SEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQ----ETSRPSVAKQLLADKYQP 443
+ +R Q AL + + + E+ A+ T Q E ++ QL +Q
Sbjct: 2280 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2339
Query: 444 DTELPETQRLQSE------------------------LDVLDADIVLEEGPFILDQSASF 479
+ E QRL++E L L A I E IL
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---- 2395
Query: 480 KDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQ---SQPHSKSRVQQ 536
KD + +A K K V E AR + L + + +Q ++ K ++Q
Sbjct: 2396 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2455
Query: 537 TTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQE 596
++RLK + ++ +K A + + D KE + Q+ +E
Sbjct: 2456 VQEATRLKAEAELLQQQKE----------------LAQEQARRLQED--KEQMAQQLAEE 2497
Query: 597 ESHLTGAVEHEAARLAWLDAETSK---RLKELEELKAKEIDSMQKQRLDWLD-AETSRRT 652
+E E R + AE + R+ E+ +A+ + Q+ R + E RT
Sbjct: 2498 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2557
Query: 653 KELNELKAEEMYRLQQLSVSATHLADKVEEAV--LDRLKPLLVKAQRVNSTTEANIHLKD 710
+ + K + L+ + H A+++ EA+ L+R K L + ++ + LK
Sbjct: 2558 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-------LQLKS 2610
Query: 711 GSSVNTAKAQPAQEVAAVD----FESNNIRQLDDFLEDCASELWAVTHAKILGSETL--- 763
+ Q QE A+ E +++ Q + F+E ++L + ++ ++ L
Sbjct: 2611 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2670
Query: 764 ----------------ATVEDSK--DSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
A++E+++ E + R+ EE+++ ++ RQ+ +A + R
Sbjct: 2671 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730
Query: 806 L--WMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTE 863
L +Q + + + ++ + TKT+ A++ +S D
Sbjct: 2731 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2790
Query: 864 EGSEKREAPLLSLAEDSQQKEG 885
+EA +LS E + +G
Sbjct: 2791 SAQRLQEAGILSAEELQRLAQG 2812
Score = 43.5 bits (101), Expect = 0.001
Identities = 135/634 (21%), Positives = 259/634 (40%), Gaps = 83/634 (13%)
Query: 218 EVQRLQKELSSCIH---KIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQ 274
E++R Q + + + + EEV ++ L +A + E++ +E+A R AR ++
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQA---EAEKQ-----KEEAEREARRRGKAEE 1818
Query: 275 QVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCK 334
Q Q EL + K + + A +LAA IR + T++GE +
Sbjct: 1819 QAVR-QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIR-----LRAETEQGEQQRQLLEE 1871
Query: 335 ELGSLIRQLSLCSVK---LDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIR 391
EL L R+ + + K L+A+ + +++L +A + S K ++ +E
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA- 1930
Query: 392 SRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQ 451
RF +++A +R L +D Q A+++LA+K + E
Sbjct: 1931 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKL---AAIGEAT 1983
Query: 452 RLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDT--- 508
RL++E A+I L+E + + + +A+ +A +++ + E K D
Sbjct: 1984 RLKTE-----AEIALKE-------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031
Query: 509 LAPARQQGLRKAERGR---QSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPW------IP 559
LA R+ + ER + + + +V++ ++ LK + + KA I
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEKAAAGKAELELELGRIR 2089
Query: 560 PNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETS 619
N S K A L+ + A +E ++ + +E + A E EAAR +
Sbjct: 2090 SNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR------QRK 2142
Query: 620 KRLKELEELKAKEIDSMQ-KQRLDWLDAETSRRTKEL--NELKAEE---MYRLQQLSVSA 673
L+E+E LKAK ++ + ++R + A + +E L+AEE + +QQ
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2202
Query: 674 THLADKVEEAVLDRLKPLLVKAQR-VNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFES 732
+ E++VLD+L+ A+R EA + A+ + AQ V+ E+
Sbjct: 2203 QQTLQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQ---------AEREAAQSRRQVE-EA 2251
Query: 733 NNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESV 792
++Q + ++ A +E A + L EMEK+++
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2311
Query: 793 RQRYNKIAYADPRLW---MQEENNDQKISAISEK 823
Q + A + L +Q E D + + + E+
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345
Score = 40.0 bits (92), Expect = 0.011
Identities = 104/491 (21%), Positives = 191/491 (38%), Gaps = 106/491 (21%)
Query: 207 HKNISEQKSLLEVQRLQKELSSCIHKIEEVT-KKDRLEEALDPDEERRIRIRRQEQAARS 265
HK +EQ +L + ++++EL++ ++EE +K+ L+E L R + +A +
Sbjct: 2307 HKKFAEQ-TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ---------RLKAEATEA 2356
Query: 266 ARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRG 325
AR +++++ ++ ++++LS KL A RAL + T R
Sbjct: 2357 ARQRSQVEEELFSVRVQMEELS--------------KLKARIEAENRALILRDKDNTQRF 2402
Query: 326 EHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKK 385
+ K++ +LS+ + + + + D+ QQ E +L++K+ +
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEKMLKEKMQAVQ--- 2457
Query: 386 CFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDT 445
+T K E L + QE +R +L DK Q
Sbjct: 2458 --------------------EATRLKAEAELLQQQKELAQEQAR-----RLQEDKEQMAQ 2492
Query: 446 ELPE-TQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFR 504
+L E TQ Q L+ E L+ SA + L VA+ + + + FR
Sbjct: 2493 QLAEETQGFQRTLEA--------ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2544
Query: 505 KK----------------------DTLAPARQQGLRKAERGRQS---QPHSKSRVQQTTV 539
K+ TL RQQ AER R++ K ++QQ
Sbjct: 2545 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2604
Query: 540 SSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQED--PQEE 597
+LK ++ + A + S +D+ LQ+E QE+
Sbjct: 2605 LLQLKSEEMQTVQQEQ-----------LLQETQALQQSFLSEKDSL---LQRERFIEQEK 2650
Query: 598 SHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNE 657
+ L + E A+ L E ++ +++E+ + + + SM++ R +AE R K+ E
Sbjct: 2651 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ-EE 2709
Query: 658 LKAEEMYRLQQ 668
L+ E R QQ
Sbjct: 2710 LQQLEQQRRQQ 2720
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 54.3 bits (129), Expect = 5e-07
Identities = 147/730 (20%), Positives = 284/730 (38%), Gaps = 131/730 (17%)
Query: 203 RIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQA 262
R+ + + ++EQ+ E +RL E+ + + K ++ + +A E + ++ R QE+
Sbjct: 1321 RMEEEERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379
Query: 263 ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIR--------AL 314
R QQQ + IQEEL +L + + + AA R +R L
Sbjct: 1380 VRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1437
Query: 315 QMFVTQFTDRGE----HPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEAL 370
Q+ T+ G L AR +E + RQ ++ E L
Sbjct: 1438 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--------------------EEAERL 1477
Query: 371 ESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRP 430
++ + K+ + E+ SR ++ A E+ + E R L A++
Sbjct: 1478 RRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELR-LQAEE--------- 1525
Query: 431 SVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTK 490
A++ E+ +++Q L+ E + + ASF + KT
Sbjct: 1526 -------AERRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAE------KTA 1568
Query: 491 AGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQ-QTTVSSRLKMNRQP 549
++ E+V + A R Q +AER R+ R Q + + RL++ +
Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628
Query: 550 VKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAA 609
V +K+ + +A K Q+E+ + E+ G E +A
Sbjct: 1629 VAQQKS-----------------------LAQAEAEK---QKEEAEREARRRGKAEEQAV 1662
Query: 610 RLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQL 669
R L + ++ ++L E A++ +Q L L AET + ++ +L EE+ RLQ+
Sbjct: 1663 RQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQGEQQ-RQLLEEELARLQRE 1720
Query: 670 SVSATHLADKVE---EAVLDRLKPLLVKAQRV----NSTTEANIHLKDGSSVNTAK-AQP 721
+ +AT ++E V ++ LL R ST+E + + + + A+
Sbjct: 1721 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780
Query: 722 AQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEI---- 777
A + A+ E+ RQL + ED A + ++L + A E ++ + EI
Sbjct: 1781 AARLRALAEEAKRQRQLAE--EDAARQ--RAEAERVLAEKLAAIGEATRLKTEAEIALKE 1836
Query: 778 ------MMRRMEEMEKYQES--VRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHP 829
+RR+ E E +Q Q A + RL + +D ++ +K L
Sbjct: 1837 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE--RQKGLVEDT 1894
Query: 830 IRITKTVDRKDPAVNIMLERPCNG------------NSLDESVGTEEGSEKREAPLLSLA 877
+R + V+ + A+ E+ G ++ ++++ ++E +E A LA
Sbjct: 1895 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1954
Query: 878 EDSQQKEGRA 887
+ +++ A
Sbjct: 1955 AEEERRRREA 1964
Score = 45.1 bits (105), Expect = 3e-04
Identities = 136/742 (18%), Positives = 281/742 (37%), Gaps = 126/742 (16%)
Query: 213 QKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVL 272
QKSL + ++ + + ++E + K ++EEA RR+R R ++++AR ++
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERL--KAKVEEA------RRLRERAEQESARQLQLAQEA 2020
Query: 273 QQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPAR 332
Q+ + +E+ H +K + + + + L RGE R
Sbjct: 2021 AQKRLQAEEKA-----HAFAVQQKEQELQQTLQQEQSVLDQL---------RGEAEAARR 2066
Query: 333 CKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI-----EALESLLEKKLSPKKVKKCF 387
E R V+ + + + ++ +++ E ++ + + + +K++K
Sbjct: 2067 AAEEAEEAR------VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2120
Query: 388 SEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQ----ETSRPSVAKQLLADKYQP 443
+ +R Q AL + + + E+ A+ T Q E ++ QL +Q
Sbjct: 2121 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2180
Query: 444 DTELPETQRLQSE------------------------LDVLDADIVLEEGPFILDQSASF 479
+ E QRL++E L L A I E IL
Sbjct: 2181 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---- 2236
Query: 480 KDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQ---SQPHSKSRVQQ 536
KD + +A K K V E AR + L + + +Q ++ K ++Q
Sbjct: 2237 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2296
Query: 537 TTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQE 596
++RLK + ++ +K A + + D KE + Q+ +E
Sbjct: 2297 VQEATRLKAEAELLQQQKE----------------LAQEQARRLQED--KEQMAQQLAEE 2338
Query: 597 ESHLTGAVEHEAARLAWLDAETSK---RLKELEELKAKEIDSMQKQRLDWLD-AETSRRT 652
+E E R + AE + R+ E+ +A+ + Q+ R + E RT
Sbjct: 2339 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2398
Query: 653 KELNELKAEEMYRLQQLSVSATHLADKVEEAV--LDRLKPLLVKAQRVNSTTEANIHLKD 710
+ + K + L+ + H A+++ EA+ L+R K L + ++ + LK
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-------LQLKS 2451
Query: 711 GSSVNTAKAQPAQEVAAVD----FESNNIRQLDDFLEDCASELWAVTHAKILGSETL--- 763
+ Q QE A+ E +++ Q + F+E ++L + ++ ++ L
Sbjct: 2452 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2511
Query: 764 ----------------ATVEDSK--DSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
A++E+++ E + R+ EE+++ ++ RQ+ +A + R
Sbjct: 2512 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571
Query: 806 L--WMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTE 863
L +Q + + + ++ + TKT+ A++ +S D
Sbjct: 2572 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2631
Query: 864 EGSEKREAPLLSLAEDSQQKEG 885
+EA +LS E + +G
Sbjct: 2632 SAQRLQEAGILSAEELQRLAQG 2653
Score = 43.5 bits (101), Expect = 0.001
Identities = 135/634 (21%), Positives = 259/634 (40%), Gaps = 83/634 (13%)
Query: 218 EVQRLQKELSSCIH---KIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQ 274
E++R Q + + + + EEV ++ L +A + E++ +E+A R AR ++
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQA---EAEKQ-----KEEAEREARRRGKAEE 1659
Query: 275 QVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCK 334
Q Q EL + K + + A +LAA IR + T++GE +
Sbjct: 1660 QAVR-QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIR-----LRAETEQGEQQRQLLEE 1712
Query: 335 ELGSLIRQLSLCSVK---LDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIR 391
EL L R+ + + K L+A+ + +++L +A + S K ++ +E
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA- 1771
Query: 392 SRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQ 451
RF +++A +R L +D Q A+++LA+K + E
Sbjct: 1772 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKL---AAIGEAT 1824
Query: 452 RLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDT--- 508
RL++E A+I L+E + + + +A+ +A +++ + E K D
Sbjct: 1825 RLKTE-----AEIALKE-------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872
Query: 509 LAPARQQGLRKAERGR---QSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPW------IP 559
LA R+ + ER + + + +V++ ++ LK + + KA I
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEKAAAGKAELELELGRIR 1930
Query: 560 PNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETS 619
N S K A L+ + A +E ++ + +E + A E EAAR +
Sbjct: 1931 SNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR------QRK 1983
Query: 620 KRLKELEELKAKEIDSMQ-KQRLDWLDAETSRRTKEL--NELKAEE---MYRLQQLSVSA 673
L+E+E LKAK ++ + ++R + A + +E L+AEE + +QQ
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2043
Query: 674 THLADKVEEAVLDRLKPLLVKAQR-VNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFES 732
+ E++VLD+L+ A+R EA + A+ + AQ V+ E+
Sbjct: 2044 QQTLQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQ---------AEREAAQSRRQVE-EA 2092
Query: 733 NNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESV 792
++Q + ++ A +E A + L EMEK+++
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2152
Query: 793 RQRYNKIAYADPRLW---MQEENNDQKISAISEK 823
Q + A + L +Q E D + + + E+
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186
Score = 40.0 bits (92), Expect = 0.011
Identities = 104/491 (21%), Positives = 191/491 (38%), Gaps = 106/491 (21%)
Query: 207 HKNISEQKSLLEVQRLQKELSSCIHKIEEVT-KKDRLEEALDPDEERRIRIRRQEQAARS 265
HK +EQ +L + ++++EL++ ++EE +K+ L+E L R + +A +
Sbjct: 2148 HKKFAEQ-TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ---------RLKAEATEA 2197
Query: 266 ARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRG 325
AR +++++ ++ ++++LS KL A RAL + T R
Sbjct: 2198 ARQRSQVEEELFSVRVQMEELS--------------KLKARIEAENRALILRDKDNTQRF 2243
Query: 326 EHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKK 385
+ K++ +LS+ + + + + D+ QQ E +L++K+ +
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEKMLKEKMQAVQ--- 2298
Query: 386 CFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDT 445
+T K E L + QE +R +L DK Q
Sbjct: 2299 --------------------EATRLKAEAELLQQQKELAQEQAR-----RLQEDKEQMAQ 2333
Query: 446 ELPE-TQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFR 504
+L E TQ Q L+ E L+ SA + L VA+ + + + FR
Sbjct: 2334 QLAEETQGFQRTLEA--------ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2385
Query: 505 KK----------------------DTLAPARQQGLRKAERGRQS---QPHSKSRVQQTTV 539
K+ TL RQQ AER R++ K ++QQ
Sbjct: 2386 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2445
Query: 540 SSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQED--PQEE 597
+LK ++ + A + S +D+ LQ+E QE+
Sbjct: 2446 LLQLKSEEMQTVQQEQ-----------LLQETQALQQSFLSEKDSL---LQRERFIEQEK 2491
Query: 598 SHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNE 657
+ L + E A+ L E ++ +++E+ + + + SM++ R +AE R K+ E
Sbjct: 2492 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ-EE 2550
Query: 658 LKAEEMYRLQQ 668
L+ E R QQ
Sbjct: 2551 LQQLEQQRRQQ 2561
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 54.3 bits (129), Expect = 5e-07
Identities = 147/730 (20%), Positives = 284/730 (38%), Gaps = 131/730 (17%)
Query: 203 RIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQA 262
R+ + + ++EQ+ E +RL E+ + + K ++ + +A E + ++ R QE+
Sbjct: 1329 RMEEEERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387
Query: 263 ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIR--------AL 314
R QQQ + IQEEL +L + + + AA R +R L
Sbjct: 1388 VRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1445
Query: 315 QMFVTQFTDRGE----HPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEAL 370
Q+ T+ G L AR +E + RQ ++ E L
Sbjct: 1446 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--------------------EEAERL 1485
Query: 371 ESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRP 430
++ + K+ + E+ SR ++ A E+ + E R L A++
Sbjct: 1486 RRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELR-LQAEE--------- 1533
Query: 431 SVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTK 490
A++ E+ +++Q L+ E + + ASF + KT
Sbjct: 1534 -------AERRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAE------KTA 1576
Query: 491 AGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQ-QTTVSSRLKMNRQP 549
++ E+V + A R Q +AER R+ R Q + + RL++ +
Sbjct: 1577 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636
Query: 550 VKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAA 609
V +K+ + +A K Q+E+ + E+ G E +A
Sbjct: 1637 VAQQKS-----------------------LAQAEAEK---QKEEAEREARRRGKAEEQAV 1670
Query: 610 RLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQL 669
R L + ++ ++L E A++ +Q L L AET + ++ +L EE+ RLQ+
Sbjct: 1671 RQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQGEQQ-RQLLEEELARLQRE 1728
Query: 670 SVSATHLADKVE---EAVLDRLKPLLVKAQRV----NSTTEANIHLKDGSSVNTAK-AQP 721
+ +AT ++E V ++ LL R ST+E + + + + A+
Sbjct: 1729 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1788
Query: 722 AQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEI---- 777
A + A+ E+ RQL + ED A + ++L + A E ++ + EI
Sbjct: 1789 AARLRALAEEAKRQRQLAE--EDAARQ--RAEAERVLAEKLAAIGEATRLKTEAEIALKE 1844
Query: 778 ------MMRRMEEMEKYQES--VRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHP 829
+RR+ E E +Q Q A + RL + +D ++ +K L
Sbjct: 1845 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE--RQKGLVEDT 1902
Query: 830 IRITKTVDRKDPAVNIMLERPCNG------------NSLDESVGTEEGSEKREAPLLSLA 877
+R + V+ + A+ E+ G ++ ++++ ++E +E A LA
Sbjct: 1903 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1962
Query: 878 EDSQQKEGRA 887
+ +++ A
Sbjct: 1963 AEEERRRREA 1972
Score = 45.1 bits (105), Expect = 3e-04
Identities = 136/742 (18%), Positives = 281/742 (37%), Gaps = 126/742 (16%)
Query: 213 QKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVL 272
QKSL + ++ + + ++E + K ++EEA RR+R R ++++AR ++
Sbjct: 1977 QKSLAAEEEAARQRKAALEEVERL--KAKVEEA------RRLRERAEQESARQLQLAQEA 2028
Query: 273 QQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPAR 332
Q+ + +E+ H +K + + + + L RGE R
Sbjct: 2029 AQKRLQAEEKA-----HAFAVQQKEQELQQTLQQEQSVLDQL---------RGEAEAARR 2074
Query: 333 CKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI-----EALESLLEKKLSPKKVKKCF 387
E R V+ + + + ++ +++ E ++ + + + +K++K
Sbjct: 2075 AAEEAEEAR------VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2128
Query: 388 SEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQ----ETSRPSVAKQLLADKYQP 443
+ +R Q AL + + + E+ A+ T Q E ++ QL +Q
Sbjct: 2129 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2188
Query: 444 DTELPETQRLQSE------------------------LDVLDADIVLEEGPFILDQSASF 479
+ E QRL++E L L A I E IL
Sbjct: 2189 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---- 2244
Query: 480 KDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQ---SQPHSKSRVQQ 536
KD + +A K K V E AR + L + + +Q ++ K ++Q
Sbjct: 2245 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2304
Query: 537 TTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQE 596
++RLK + ++ +K A + + D KE + Q+ +E
Sbjct: 2305 VQEATRLKAEAELLQQQKE----------------LAQEQARRLQED--KEQMAQQLAEE 2346
Query: 597 ESHLTGAVEHEAARLAWLDAETSK---RLKELEELKAKEIDSMQKQRLDWLD-AETSRRT 652
+E E R + AE + R+ E+ +A+ + Q+ R + E RT
Sbjct: 2347 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2406
Query: 653 KELNELKAEEMYRLQQLSVSATHLADKVEEAV--LDRLKPLLVKAQRVNSTTEANIHLKD 710
+ + K + L+ + H A+++ EA+ L+R K L + ++ + LK
Sbjct: 2407 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-------LQLKS 2459
Query: 711 GSSVNTAKAQPAQEVAAVD----FESNNIRQLDDFLEDCASELWAVTHAKILGSETL--- 763
+ Q QE A+ E +++ Q + F+E ++L + ++ ++ L
Sbjct: 2460 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2519
Query: 764 ----------------ATVEDSK--DSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
A++E+++ E + R+ EE+++ ++ RQ+ +A + R
Sbjct: 2520 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2579
Query: 806 L--WMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTE 863
L +Q + + + ++ + TKT+ A++ +S D
Sbjct: 2580 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2639
Query: 864 EGSEKREAPLLSLAEDSQQKEG 885
+EA +LS E + +G
Sbjct: 2640 SAQRLQEAGILSAEELQRLAQG 2661
Score = 43.5 bits (101), Expect = 0.001
Identities = 135/634 (21%), Positives = 259/634 (40%), Gaps = 83/634 (13%)
Query: 218 EVQRLQKELSSCIH---KIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQ 274
E++R Q + + + + EEV ++ L +A + E++ +E+A R AR ++
Sbjct: 1616 ELERWQLKANEALRLRLQAEEVAQQKSLAQA---EAEKQ-----KEEAEREARRRGKAEE 1667
Query: 275 QVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCK 334
Q Q EL + K + + A +LAA IR + T++GE +
Sbjct: 1668 QAVR-QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIR-----LRAETEQGEQQRQLLEE 1720
Query: 335 ELGSLIRQLSLCSVK---LDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIR 391
EL L R+ + + K L+A+ + +++L +A + S K ++ +E
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA- 1779
Query: 392 SRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQ 451
RF +++A +R L +D Q A+++LA+K + E
Sbjct: 1780 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKL---AAIGEAT 1832
Query: 452 RLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDT--- 508
RL++E A+I L+E + + + +A+ +A +++ + E K D
Sbjct: 1833 RLKTE-----AEIALKE-------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880
Query: 509 LAPARQQGLRKAERGR---QSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPW------IP 559
LA R+ + ER + + + +V++ ++ LK + + KA I
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEKAAAGKAELELELGRIR 1938
Query: 560 PNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETS 619
N S K A L+ + A +E ++ + +E + A E EAAR +
Sbjct: 1939 SNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR------QRK 1991
Query: 620 KRLKELEELKAKEIDSMQ-KQRLDWLDAETSRRTKEL--NELKAEE---MYRLQQLSVSA 673
L+E+E LKAK ++ + ++R + A + +E L+AEE + +QQ
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2051
Query: 674 THLADKVEEAVLDRLKPLLVKAQR-VNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFES 732
+ E++VLD+L+ A+R EA + A+ + AQ V+ E+
Sbjct: 2052 QQTLQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQ---------AEREAAQSRRQVE-EA 2100
Query: 733 NNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESV 792
++Q + ++ A +E A + L EMEK+++
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2160
Query: 793 RQRYNKIAYADPRLW---MQEENNDQKISAISEK 823
Q + A + L +Q E D + + + E+
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194
Score = 40.0 bits (92), Expect = 0.011
Identities = 104/491 (21%), Positives = 191/491 (38%), Gaps = 106/491 (21%)
Query: 207 HKNISEQKSLLEVQRLQKELSSCIHKIEEVT-KKDRLEEALDPDEERRIRIRRQEQAARS 265
HK +EQ +L + ++++EL++ ++EE +K+ L+E L R + +A +
Sbjct: 2156 HKKFAEQ-TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ---------RLKAEATEA 2205
Query: 266 ARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRG 325
AR +++++ ++ ++++LS KL A RAL + T R
Sbjct: 2206 ARQRSQVEEELFSVRVQMEELS--------------KLKARIEAENRALILRDKDNTQRF 2251
Query: 326 EHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKK 385
+ K++ +LS+ + + + + D+ QQ E +L++K+ +
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEKMLKEKMQAVQ--- 2306
Query: 386 CFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDT 445
+T K E L + QE +R +L DK Q
Sbjct: 2307 --------------------EATRLKAEAELLQQQKELAQEQAR-----RLQEDKEQMAQ 2341
Query: 446 ELPE-TQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFR 504
+L E TQ Q L+ E L+ SA + L VA+ + + + FR
Sbjct: 2342 QLAEETQGFQRTLEA--------ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2393
Query: 505 KK----------------------DTLAPARQQGLRKAERGRQS---QPHSKSRVQQTTV 539
K+ TL RQQ AER R++ K ++QQ
Sbjct: 2394 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2453
Query: 540 SSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQED--PQEE 597
+LK ++ + A + S +D+ LQ+E QE+
Sbjct: 2454 LLQLKSEEMQTVQQEQ-----------LLQETQALQQSFLSEKDSL---LQRERFIEQEK 2499
Query: 598 SHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNE 657
+ L + E A+ L E ++ +++E+ + + + SM++ R +AE R K+ E
Sbjct: 2500 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ-EE 2558
Query: 658 LKAEEMYRLQQ 668
L+ E R QQ
Sbjct: 2559 LQQLEQQRRQQ 2569
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 54.3 bits (129), Expect = 5e-07
Identities = 147/730 (20%), Positives = 284/730 (38%), Gaps = 131/730 (17%)
Query: 203 RIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQA 262
R+ + + ++EQ+ E +RL E+ + + K ++ + +A E + ++ R QE+
Sbjct: 1370 RMEEEERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428
Query: 263 ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIR--------AL 314
R QQQ + IQEEL +L + + + AA R +R L
Sbjct: 1429 VRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1486
Query: 315 QMFVTQFTDRGE----HPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEAL 370
Q+ T+ G L AR +E + RQ ++ E L
Sbjct: 1487 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--------------------EEAERL 1526
Query: 371 ESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRP 430
++ + K+ + E+ SR ++ A E+ + E R L A++
Sbjct: 1527 RRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELR-LQAEE--------- 1574
Query: 431 SVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTK 490
A++ E+ +++Q L+ E + + ASF + KT
Sbjct: 1575 -------AERRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAE------KTA 1617
Query: 491 AGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQ-QTTVSSRLKMNRQP 549
++ E+V + A R Q +AER R+ R Q + + RL++ +
Sbjct: 1618 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677
Query: 550 VKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAA 609
V +K+ + +A K Q+E+ + E+ G E +A
Sbjct: 1678 VAQQKS-----------------------LAQAEAEK---QKEEAEREARRRGKAEEQAV 1711
Query: 610 RLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQL 669
R L + ++ ++L E A++ +Q L L AET + ++ +L EE+ RLQ+
Sbjct: 1712 RQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQGEQQ-RQLLEEELARLQRE 1769
Query: 670 SVSATHLADKVE---EAVLDRLKPLLVKAQRV----NSTTEANIHLKDGSSVNTAK-AQP 721
+ +AT ++E V ++ LL R ST+E + + + + A+
Sbjct: 1770 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1829
Query: 722 AQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEI---- 777
A + A+ E+ RQL + ED A + ++L + A E ++ + EI
Sbjct: 1830 AARLRALAEEAKRQRQLAE--EDAARQ--RAEAERVLAEKLAAIGEATRLKTEAEIALKE 1885
Query: 778 ------MMRRMEEMEKYQES--VRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHP 829
+RR+ E E +Q Q A + RL + +D ++ +K L
Sbjct: 1886 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE--RQKGLVEDT 1943
Query: 830 IRITKTVDRKDPAVNIMLERPCNG------------NSLDESVGTEEGSEKREAPLLSLA 877
+R + V+ + A+ E+ G ++ ++++ ++E +E A LA
Sbjct: 1944 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2003
Query: 878 EDSQQKEGRA 887
+ +++ A
Sbjct: 2004 AEEERRRREA 2013
Score = 45.1 bits (105), Expect = 3e-04
Identities = 136/742 (18%), Positives = 281/742 (37%), Gaps = 126/742 (16%)
Query: 213 QKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVL 272
QKSL + ++ + + ++E + K ++EEA RR+R R ++++AR ++
Sbjct: 2018 QKSLAAEEEAARQRKAALEEVERL--KAKVEEA------RRLRERAEQESARQLQLAQEA 2069
Query: 273 QQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPAR 332
Q+ + +E+ H +K + + + + L RGE R
Sbjct: 2070 AQKRLQAEEKA-----HAFAVQQKEQELQQTLQQEQSVLDQL---------RGEAEAARR 2115
Query: 333 CKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI-----EALESLLEKKLSPKKVKKCF 387
E R V+ + + + ++ +++ E ++ + + + +K++K
Sbjct: 2116 AAEEAEEAR------VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2169
Query: 388 SEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQ----ETSRPSVAKQLLADKYQP 443
+ +R Q AL + + + E+ A+ T Q E ++ QL +Q
Sbjct: 2170 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2229
Query: 444 DTELPETQRLQSE------------------------LDVLDADIVLEEGPFILDQSASF 479
+ E QRL++E L L A I E IL
Sbjct: 2230 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---- 2285
Query: 480 KDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQ---SQPHSKSRVQQ 536
KD + +A K K V E AR + L + + +Q ++ K ++Q
Sbjct: 2286 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2345
Query: 537 TTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQE 596
++RLK + ++ +K A + + D KE + Q+ +E
Sbjct: 2346 VQEATRLKAEAELLQQQKE----------------LAQEQARRLQED--KEQMAQQLAEE 2387
Query: 597 ESHLTGAVEHEAARLAWLDAETSK---RLKELEELKAKEIDSMQKQRLDWLD-AETSRRT 652
+E E R + AE + R+ E+ +A+ + Q+ R + E RT
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447
Query: 653 KELNELKAEEMYRLQQLSVSATHLADKVEEAV--LDRLKPLLVKAQRVNSTTEANIHLKD 710
+ + K + L+ + H A+++ EA+ L+R K L + ++ + LK
Sbjct: 2448 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-------LQLKS 2500
Query: 711 GSSVNTAKAQPAQEVAAVD----FESNNIRQLDDFLEDCASELWAVTHAKILGSETL--- 763
+ Q QE A+ E +++ Q + F+E ++L + ++ ++ L
Sbjct: 2501 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2560
Query: 764 ----------------ATVEDSK--DSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
A++E+++ E + R+ EE+++ ++ RQ+ +A + R
Sbjct: 2561 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2620
Query: 806 L--WMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTE 863
L +Q + + + ++ + TKT+ A++ +S D
Sbjct: 2621 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2680
Query: 864 EGSEKREAPLLSLAEDSQQKEG 885
+EA +LS E + +G
Sbjct: 2681 SAQRLQEAGILSAEELQRLAQG 2702
Score = 43.5 bits (101), Expect = 0.001
Identities = 135/634 (21%), Positives = 259/634 (40%), Gaps = 83/634 (13%)
Query: 218 EVQRLQKELSSCIH---KIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQ 274
E++R Q + + + + EEV ++ L +A + E++ +E+A R AR ++
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQA---EAEKQ-----KEEAEREARRRGKAEE 1708
Query: 275 QVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCK 334
Q Q EL + K + + A +LAA IR + T++GE +
Sbjct: 1709 QAVR-QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIR-----LRAETEQGEQQRQLLEE 1761
Query: 335 ELGSLIRQLSLCSVK---LDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIR 391
EL L R+ + + K L+A+ + +++L +A + S K ++ +E
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA- 1820
Query: 392 SRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQ 451
RF +++A +R L +D Q A+++LA+K + E
Sbjct: 1821 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKL---AAIGEAT 1873
Query: 452 RLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDT--- 508
RL++E A+I L+E + + + +A+ +A +++ + E K D
Sbjct: 1874 RLKTE-----AEIALKE-------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921
Query: 509 LAPARQQGLRKAERGR---QSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPW------IP 559
LA R+ + ER + + + +V++ ++ LK + + KA I
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEKAAAGKAELELELGRIR 1979
Query: 560 PNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETS 619
N S K A L+ + A +E ++ + +E + A E EAAR +
Sbjct: 1980 SNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR------QRK 2032
Query: 620 KRLKELEELKAKEIDSMQ-KQRLDWLDAETSRRTKEL--NELKAEE---MYRLQQLSVSA 673
L+E+E LKAK ++ + ++R + A + +E L+AEE + +QQ
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2092
Query: 674 THLADKVEEAVLDRLKPLLVKAQR-VNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFES 732
+ E++VLD+L+ A+R EA + A+ + AQ V+ E+
Sbjct: 2093 QQTLQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQ---------AEREAAQSRRQVE-EA 2141
Query: 733 NNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESV 792
++Q + ++ A +E A + L EMEK+++
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2201
Query: 793 RQRYNKIAYADPRLW---MQEENNDQKISAISEK 823
Q + A + L +Q E D + + + E+
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235
Score = 40.0 bits (92), Expect = 0.011
Identities = 104/491 (21%), Positives = 191/491 (38%), Gaps = 106/491 (21%)
Query: 207 HKNISEQKSLLEVQRLQKELSSCIHKIEEVT-KKDRLEEALDPDEERRIRIRRQEQAARS 265
HK +EQ +L + ++++EL++ ++EE +K+ L+E L R + +A +
Sbjct: 2197 HKKFAEQ-TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ---------RLKAEATEA 2246
Query: 266 ARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRG 325
AR +++++ ++ ++++LS KL A RAL + T R
Sbjct: 2247 ARQRSQVEEELFSVRVQMEELS--------------KLKARIEAENRALILRDKDNTQRF 2292
Query: 326 EHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKK 385
+ K++ +LS+ + + + + D+ QQ E +L++K+ +
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEKMLKEKMQAVQ--- 2347
Query: 386 CFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDT 445
+T K E L + QE +R +L DK Q
Sbjct: 2348 --------------------EATRLKAEAELLQQQKELAQEQAR-----RLQEDKEQMAQ 2382
Query: 446 ELPE-TQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFR 504
+L E TQ Q L+ E L+ SA + L VA+ + + + FR
Sbjct: 2383 QLAEETQGFQRTLEA--------ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2434
Query: 505 KK----------------------DTLAPARQQGLRKAERGRQS---QPHSKSRVQQTTV 539
K+ TL RQQ AER R++ K ++QQ
Sbjct: 2435 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2494
Query: 540 SSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQED--PQEE 597
+LK ++ + A + S +D+ LQ+E QE+
Sbjct: 2495 LLQLKSEEMQTVQQEQ-----------LLQETQALQQSFLSEKDSL---LQRERFIEQEK 2540
Query: 598 SHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNE 657
+ L + E A+ L E ++ +++E+ + + + SM++ R +AE R K+ E
Sbjct: 2541 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ-EE 2599
Query: 658 LKAEEMYRLQQ 668
L+ E R QQ
Sbjct: 2600 LQQLEQQRRQQ 2610
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 51.2 bits (121), Expect = 5e-06
Identities = 46/214 (21%), Positives = 97/214 (45%), Gaps = 20/214 (9%)
Query: 617 ETSKRLKELEELKAKEIDSMQKQR-LDWLDAETSRRTKELNELKAEEMYRLQQLSVSATH 675
E ++++E EE ++ + M++Q + W E RR +E+ K E+M R +++
Sbjct: 379 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 438
Query: 676 LADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNI 735
++EE + ++ K ++ Q E I ++ AK +E I
Sbjct: 439 KIRELEEKMHEQEK---IREQEEKRQEEEKIREQEKRQEQEAKMWRQEE---------KI 486
Query: 736 RQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDL---EIMMRRMEEMEKYQESV 792
R+ ++ + + ++W KI E + E ++ ++ E +R EE+ + +E +
Sbjct: 487 REQEEKIREQEEKMWR-QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKI 545
Query: 793 RQRYNKIAYADPRLWMQEE---NNDQKISAISEK 823
++ KI + ++W QEE + ++KI EK
Sbjct: 546 HEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEK 579
Score = 35.4 bits (80), Expect = 0.26
Identities = 126/711 (17%), Positives = 268/711 (37%), Gaps = 119/711 (16%)
Query: 116 HIKEHHLRSQPQSSQKCGHTKYKIPDHRVERKESKSQAACQCSHQPSKVEISSSGAKVYL 175
H+ H + S+ K K ++ DH + S AA K +I++
Sbjct: 105 HLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTK----KKKINNG------ 154
Query: 176 YSSHPGQSDLTVPNSPPTHDPGLQPHPRIGDHKNISEQKSLLEVQR-LQKELSSCIHKIE 234
+P T G G H EQK+ + Q L++EL + +H I
Sbjct: 155 -------------TNPETTTSG-------GCHSPEDEQKASHQHQEALRRELEAQVHTIR 194
Query: 235 EVT-KKDRLEEALDPDEERRIRIRRQEQAARSA-RMLYVLQQQVKEIQEELDKLSPHKIK 292
+T +K L+ AL + +++ E AR L+ + E+++ L ++ K K
Sbjct: 195 ILTCQKTELQMALYYSQHA---VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKK 251
Query: 293 HTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDA 352
+ ++K R A+ +L+++ TD A+ +E L+ ++L+
Sbjct: 252 ADRYIEELTK----ERDAL-SLELYRNTITDEELKEKNAKLQEKLQLVES-EKSEIQLN- 304
Query: 353 DPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIRS-RFPIGSQ-KALERWPSTSP 410
V ++ +++E + LL ++ + E++S + +Q + E W +
Sbjct: 305 -------VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ 357
Query: 411 KGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGP 470
+ E + ++ + + ++ + ++ + E E R Q E+ + + +
Sbjct: 358 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 417
Query: 471 FILDQSASF---------KDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAE 521
+ ++ K+E + + K +++ + E R+++ R+Q R+ +
Sbjct: 418 MMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE--KIREQEKRQEQ 475
Query: 522 RGRQSQPHSKSRVQQTTVSSRL-KMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTS 580
+ + K R Q+ + + KM RQ K + I
Sbjct: 476 EAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKI---------------------- 513
Query: 581 PRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQR 640
R+ K Q+E ++E + E W E ++ E EE K+ + M +Q
Sbjct: 514 -REEEKRQEQEEMWRQEEKIREQEE------IWRQKE---KIHEQEEKIRKQEEKMWRQE 563
Query: 641 LDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNS 700
D E R +E + EE R Q+ + + EE + ++ + + +++
Sbjct: 564 EKMHDQEEKIREQEEKVWRQEEKIREQEEKIR------EQEEKIREQEEMTQEQEEKMGE 617
Query: 701 TTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGS 760
E ++ K + +E + + IR+ ++ KI
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEE--KIREQEKKIREQEE---------------KIREQ 660
Query: 761 ETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEE 811
E + ++ K E M + E+M++ +E +R++ K+ + RL QEE
Sbjct: 661 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 711
Score = 30.8 bits (68), Expect = 6.4
Identities = 43/215 (20%), Positives = 83/215 (38%), Gaps = 20/215 (9%)
Query: 623 KELEELKAKEIDSMQKQRLD-WLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKV- 680
K EE K +E + Q+Q W E R +E + E+M+R ++ H +K+
Sbjct: 459 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEE----KIHEQEKIR 514
Query: 681 EEAVLDRLKPLLVKAQRVNSTTEA------------NIHLKDGSSVNTAKAQPAQEVAAV 728
EE + + + +++ E I ++ + QE
Sbjct: 515 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR 574
Query: 729 DFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKY 788
+ E RQ + E E KI E + ++ K E M + E+M++
Sbjct: 575 EQEEKVWRQEEKIREQ--EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 632
Query: 789 QESVRQRYNKIAYADPRLWMQEENNDQKISAISEK 823
+E +R++ KI + ++ QEE ++ + E+
Sbjct: 633 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 667
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 50.8 bits (120), Expect = 6e-06
Identities = 174/954 (18%), Positives = 381/954 (39%), Gaps = 131/954 (13%)
Query: 94 QERLSYAVHLARRDVKRRQFE--------------KHIKEHHLRSQPQSSQKCGHTKYKI 139
Q+ LS + L R++VK ++ + HI E LR+ + + K
Sbjct: 1096 QKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEA------KA 1149
Query: 140 PDHRVERKESKSQAACQCSHQPSKVEISSSGAKVYLYSSHPGQSDLTVPNSPPTHDPGLQ 199
++ + ++SQ + Q + + LYS+ Q+ +V S P G
Sbjct: 1150 AQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQ-QALGSVCESRPELSGGGD 1208
Query: 200 PHPRI-GDHKNISEQKSLLEVQRLQKELS-----SCIHKIEEVTKKDRLEEALDPDEERR 253
P + G + + +SL + L LS S +HK+ + K + + D+ ++
Sbjct: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQK 1268
Query: 254 IRIRRQEQAARSARM---LYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGA 310
+ R + A +++ L LQ+Q+ + QEE K + + + + A+ +
Sbjct: 1269 LEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSR 1328
Query: 311 IRALQMFVTQFTDRGEHPLPARCKE-LGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEA 369
+R ++ + +GE L KE L + + L V+ A S ++ + L+ +
Sbjct: 1329 LRRAEL--QRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARS 1386
Query: 370 LESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSR 429
L +++ ++ + + + + KAL+ E L + +E
Sbjct: 1387 ALKLKNEEVESERERAQALQEQGELKVAQGKALQ---------ENLALLTQTLAEREEEV 1437
Query: 430 PSVAKQLLADKYQPDTELPETQRLQ-SELDVLDADIVLEEGPFILDQSASFKDEVLAVAK 488
++ Q+ EL + + +Q + L++L D+ L Q +++ + K
Sbjct: 1438 ETLRGQI--------QELEKQREMQKAALELLSLDLKKRNQEVDLQQ-----EQIQELEK 1484
Query: 489 TKAGKKKPVTENVPF--RKKDTLAPARQQGLRKAERGRQSQPH--SKSRVQQTTVSSRLK 544
++ V E++P ++++ +++ +R+ E+ R++Q + ++ ++
Sbjct: 1485 CRS-----VLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE 1539
Query: 545 MNRQPVKDRKAPWIPPNPTSPPASPKCAAW-LKVKTSPRDATKEPLQQEDPQEES----- 598
R V+D K + + +C A L+ + ++ +++ + Q E+
Sbjct: 1540 SQRGQVQDLKKQLV---------TLECLALELEENHHKMECQQKLIKELEGQRETQRVAL 1590
Query: 599 -HLTGAVEH-------EAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSR 650
HLT +E +++++ L++ ++ +EL+E + +E+ S Q+++++ L +
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE-RDQEVKS-QREQIEELQRQKEH 1648
Query: 651 RTKELNELKAEEMYRLQQLSVSATHLA--DKVEEAVLDRLKPLLVKAQRVNSTTEANIHL 708
T++L E M + +++ V K+ E L+++K L + R +T +
Sbjct: 1649 LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQE 1708
Query: 709 KDGSSVNTAKAQPAQ----------EVAAVDFESNNIRQLDDFLEDCASELWAVTHAKIL 758
+ +KAQ + V+ + +I +L + + +L + H K+
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL-HRKVG 1767
Query: 759 GSETLAT------------VEDSKDSPDL--EIMMRRMEEMEKYQESVRQRYNKIAYADP 804
+ L + ++++++ +L + + +++E ++ Q +
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827
Query: 805 RLWMQEENNDQKISAISEKPLSPHPI---RITKTVDRKDPAVNIMLERPCNGN---SLDE 858
+ QEE +K A+ H R + D K+ A + E G +L+E
Sbjct: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887
Query: 859 SVGTEEG-SEKREAPLLSL----AEDSQQKEGRAPLFVPPGMQHSIGDYCSRFEQYLRII 913
+G S ++E LL+L AE +Q+ E +Q +Q L +
Sbjct: 1888 VLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQA--VLKERDQELEAL 1945
Query: 914 SHEAVGSFNPWLIAESFSEELVDEALGAVAAELQDMCEDYAEAVFTSEFLEAAT 967
E+ S + A + +E L EALG A LQ + E S LEA+T
Sbjct: 1946 RAESQSSRHQEEAARARAEAL-QEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
Score = 31.2 bits (69), Expect = 4.9
Identities = 53/259 (20%), Positives = 103/259 (39%), Gaps = 22/259 (8%)
Query: 582 RDATKEPLQQEDPQEESH----------LTGAVEHEAARLAWLDAET------SKRLKEL 625
RD E LQQE Q + L GA+E L E ++RL+E
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEE 1874
Query: 626 EELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVL 685
++ + + ++++ D L AE+ + K L L+ + + Q+ V L D +A
Sbjct: 1875 LAVEGRRVQALEEVLGD-LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQA 1933
Query: 686 DRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDC 745
LK + + + + ++++ H ++ + Q A A + L+ +
Sbjct: 1934 V-LKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQ--AEL 1990
Query: 746 ASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEME-KYQESVRQRYNKIAYADP 804
+ L A T A + S + L I +++ + +YQE V+Q +A D
Sbjct: 1991 SRSLEAST-ATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE 2049
Query: 805 RLWMQEENNDQKISAISEK 823
L Q+E +++++
Sbjct: 2050 ELRHQQEREQLLEKSLAQR 2068
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 50.4 bits (119), Expect = 8e-06
Identities = 141/749 (18%), Positives = 298/749 (39%), Gaps = 80/749 (10%)
Query: 240 DRLEEALDPDE--ERRIRIRRQEQAARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKS 297
D + LD E E+++R R Q+ + + + QQ +++Q E ++ + + +
Sbjct: 233 DEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLT 292
Query: 298 WAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDAD---- 353
+++L Q VTQ T KEL + ++ L L + + + D
Sbjct: 293 CLVAELQK---------QWEVTQATQN-------TVKELQTCLQGLELGAAEKEEDYHTA 336
Query: 354 -PSVPDVVIDILQQIEALESLLEKK------------LSPKKVKKCFSEIRSRFPIGSQK 400
+ ++ + Q++EA L+KK ++ +K + PI S
Sbjct: 337 LRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDA 396
Query: 401 ALERWPSTSPKGER-RPLTAKDTFPQETSRPSVAK--QLLADKYQPDTELPETQRLQSEL 457
A E GE+ + L + T +E +R A+ QL+ + + +RL E+
Sbjct: 397 AQEM----QELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEM 452
Query: 458 DVL---------DADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDT 508
L +AD + +L ++S+++E+ + + +KK E +++
Sbjct: 453 APLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRR----EKKQQQEEKELLEQEV 508
Query: 509 LAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPAS 568
+ RQ + + + SQ S Q+ + Q V + PP P P A
Sbjct: 509 RSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAG 568
Query: 569 PKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEEL 628
K A + V +S ++A +P +++ +E+ L E ++ L + KEL+ +
Sbjct: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
Query: 629 KAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLD-R 687
+ + + + +L L A+ + + ++ + L+ S HL D++E ++L R
Sbjct: 629 VGR--NQLLEGKLQALQADYQALQQRESAIQGS-LASLEAEQASIRHLGDQMEASLLAVR 685
Query: 688 LKPLLVKAQRVNSTTEANIHLKDGSSVNTAK-AQPAQEVAAVDFESNNIRQLDDFLEDCA 746
+KAQ EA + K+G + + Q++A + +R L+ +
Sbjct: 686 KAKEAMKAQMAEK--EAILQSKEGECQQLREEVEQCQQLA--EARHRELRALESQCQQQT 741
Query: 747 SELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIA--YADP 804
+ +T K G + + D++ + ++E +Q V++ ++ A
Sbjct: 742 QLIEVLTAEK--GQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKM 799
Query: 805 RLWMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTEE 864
R + +++ Q +++E L H + + ++ + ++ + + ++ E
Sbjct: 800 RAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEER 859
Query: 865 GSE--KREAPLLSLAEDSQQKEGRAPLFVPPGMQHSIGDYCSRFEQYLRIISHEAVGSFN 922
E +RE L +L E+ Q + + + + ++ EQ R + A
Sbjct: 860 ADEAQQREEELRALQEELSQAKCSS--------EEAQLEHAELQEQLHRANTDTA--ELG 909
Query: 923 PWLIAESFSEELVDEALGAVAAELQDMCE 951
+ A + +E V+EAL ELQD E
Sbjct: 910 IQVCALTVEKERVEEALACAVQELQDAKE 938
Score = 33.1 bits (74), Expect = 1.3
Identities = 146/742 (19%), Positives = 267/742 (35%), Gaps = 134/742 (18%)
Query: 105 RRDVKRRQFEKHIKEHHLRSQPQSSQKCGHTKYKIPDHRVERKESKSQAACQCSHQPSKV 164
RR+ K++Q EK + E +RS + Q ++ H + +E K Q H
Sbjct: 491 RREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDH----- 545
Query: 165 EISSSGAKVYLYSSHPG--------QSDLTVPNSPPTHDPGLQPHPRIGDHKNISEQKSL 216
+S + + PG +++ VP + + +P EQ+ L
Sbjct: 546 -LSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPE---------EEQRGL 595
Query: 217 LEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQQV 276
E Q ++ + E LE+ L R + + QA ++ LQQ+
Sbjct: 596 QEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQ--ALQQRE 653
Query: 277 KEIQEELDKLSPHK--IKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCK 334
IQ L L + I+H S LA +A + Q ++ E L ++
Sbjct: 654 SAIQGSLASLEAEQASIRHLGDQMEASLLAVR-----KAKEAMKAQMAEK-EAILQSKEG 707
Query: 335 ELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIRSRF 394
E L ++ C +A +++ ALES +++ +V
Sbjct: 708 ECQQLREEVEQCQQLAEARH----------RELRALESQCQQQTQLIEVL---------- 747
Query: 395 PIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQRLQ 454
T+ KG++ D +E +A QL + Q + E QRLQ
Sbjct: 748 -------------TAEKGQQGVGPPTDNEARE-----LAAQLALSQAQLEVHQGEVQRLQ 789
Query: 455 SELDVLDADI--VLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVP-FRKKDTLAP 511
+++ L A + L++ + Q S + VL KT + K E + ++ L
Sbjct: 790 AQVVDLQAKMRAALDDQDKVQSQ-LSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQC 848
Query: 512 ARQQGLRKAERGRQSQPHSKS-RVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPK 570
+ ++G + ER ++Q + R Q +S K
Sbjct: 849 SEREGALQEERADEAQQREEELRALQEELSQA---------------------------K 881
Query: 571 CAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKE-----L 625
C++ + L+ + QE+ H E +R++E +
Sbjct: 882 CSS-----------EEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAV 930
Query: 626 EELK-AKEIDSMQKQRLDWLDAETSRRTKELNE-LKAEE-----MYRLQQLSVSATHLAD 678
+EL+ AKE S +++ L+ A + + L E LKA + + LQ A A
Sbjct: 931 QELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQ 990
Query: 679 KVEEAVLDRLKPLLVKAQRVNSTTEANIHLKD-GSSVNTAKAQPAQEVAAVDFESNNIRQ 737
++EA L L K Q + LK+ G + + Q ++ + + +
Sbjct: 991 SLQEAAHQELNTL--KFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEK 1048
Query: 738 LDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYN 797
L D +L + T + + +D + + E + R +E+EK +++ YN
Sbjct: 1049 LKATQADMGEKL-SCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYN 1107
Query: 798 KIAYADPRLWMQEENNDQKISA 819
K+ + E NDQK+ A
Sbjct: 1108 KLC----QEVTNRERNDQKMLA 1125
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 48.5 bits (114), Expect = 3e-05
Identities = 47/214 (21%), Positives = 98/214 (45%), Gaps = 21/214 (9%)
Query: 617 ETSKRLKELEELKAKEIDSMQKQR-LDWLDAETSRRTKELNELKAEEMYRLQQLSVSATH 675
E ++++E EE ++ + M++Q + W E RR +E+ K E+M RL+++
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE 377
Query: 676 LADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNI 735
++EE + ++ K ++ Q E I ++ AK +E I
Sbjct: 378 KIRELEEKMHEQEK---IREQEEKRQEEEKIREQEKRQEQEAKMWRQEE---------KI 425
Query: 736 RQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDL---EIMMRRMEEMEKYQESV 792
R+ ++ + + ++W KI E + E ++ ++ E +R EE+ + +E +
Sbjct: 426 REQEEKIREQEKKMWR-QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKM 484
Query: 793 RQRYNKIAYADPRLWMQEE---NNDQKISAISEK 823
++ KI + ++W QEE + ++KI EK
Sbjct: 485 HEQ-EKIRKQEEKVWRQEEKMHDQEEKIREQEEK 517
Score = 38.9 bits (89), Expect = 0.023
Identities = 123/705 (17%), Positives = 274/705 (38%), Gaps = 102/705 (14%)
Query: 116 HIKEHHLRSQPQSSQKCGHTKYKIPDHRVERKESKSQAACQCSHQPSKVEISSSGAKVYL 175
H+ H + S+ K K ++ DH + S AA K +I++
Sbjct: 44 HLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTK----KKKINNG------ 93
Query: 176 YSSHPGQSDLTVPNSPPTHDPGLQPHPRIGDHKNISEQKSLLEVQR-LQKELSSCIHKIE 234
+P T G G H EQK+ + Q L++EL + +H I
Sbjct: 94 -------------TNPETTTSG-------GCHSPEDEQKASHQHQEALRRELEAQVHTIR 133
Query: 235 EVT-KKDRLEEALDPDEERRIRIRRQEQAARSA-RMLYVLQQQVKEIQEELDKLSPHKIK 292
+T +K L+ AL + +++ E AR L+ + E+++ L ++ K K
Sbjct: 134 ILTCQKTELQMALYYSQHA---VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKK 190
Query: 293 HTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDA 352
+ ++K R A+ +L+++ TD A+ +E L+ ++L+
Sbjct: 191 ADRYIEELTK----ERDAL-SLELYRNTITDEELKEKNAKLQEKLQLVES-EKSEIQLN- 243
Query: 353 DPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIRS-RFPIGSQ-KALERWPSTSP 410
V ++ +++E + LL ++ + E++S + +Q + E W +
Sbjct: 244 -------VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ 296
Query: 411 KGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGP 470
+ E + ++ + + ++ + ++ + E E R Q E+ + + +
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356
Query: 471 FILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHS 530
+ + K+E + + +K+ + + + Q+ +R+ E RQ +
Sbjct: 357 MMWE-----KEEKMRRLEEMMWEKEEKIRELEEKMHE------QEKIREQEEKRQEE--E 403
Query: 531 KSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQ 590
K R Q+ KM RQ K R+ + R+ K+ +
Sbjct: 404 KIREQEKRQEQEAKMWRQEEKIREQ----------------------EEKIREQEKKMWR 441
Query: 591 QEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSR 650
QE E+ H + E R E + ++ E+++ +E QK+++ + E R
Sbjct: 442 QE---EKIHEQEKIREEEKR-----QEQEEMWRQEEKIREQEEIWRQKEKMH--EQEKIR 491
Query: 651 RTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKD 710
+ +E + E+M+ ++ + EE + ++ + + + +++ E ++
Sbjct: 492 KQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE 551
Query: 711 GSSVNTAKAQPAQEVAA----VDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATV 766
K Q +++ + + IR+ + + + ++W KI E +
Sbjct: 552 KMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWE-QEEKIREQEEMMQE 610
Query: 767 EDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEE 811
++ K E M + E+M++ +E +R++ K+ + RL QEE
Sbjct: 611 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 655
Score = 33.5 bits (75), Expect = 0.99
Identities = 35/198 (17%), Positives = 82/198 (41%), Gaps = 34/198 (17%)
Query: 626 EELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVL 685
E+ K +E + Q+Q W E R +E+ K E+M+ +++ K EE V
Sbjct: 448 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK-EKMHEQEKIR--------KQEEKVW 498
Query: 686 DRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDC 745
+ + + + +++ E ++ K + +E IR+ ++ +++
Sbjct: 499 RQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEE---------KIREQEEMMQEQ 549
Query: 746 ASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
++ E + + E M R+ E++ + +E +R++ KI + +
Sbjct: 550 EEKMG----------------EQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEK 593
Query: 806 LWMQEENNDQKISAISEK 823
+W QEE ++ + E+
Sbjct: 594 IWEQEEKIREQEEMMQEQ 611
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 48.1 bits (113), Expect = 4e-05
Identities = 130/617 (21%), Positives = 247/617 (40%), Gaps = 100/617 (16%)
Query: 241 RLEEALDPDEERRIRIRRQEQAARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAM 300
+L++ + ++++ + QA+ ++ ++ + E+LD+ +P++ +S+A
Sbjct: 4 KLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
Query: 301 SKLAAAHRGAIRALQMFVTQFTDRGEHPLPA---RCKELGSLIRQLSLCSV-KLDADPSV 356
LQ+ V P+ R SL+R S S+ +LD D S
Sbjct: 64 K------------LQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSST 111
Query: 357 P--DVVIDILQQIEAL----ESLLEKKLSPK--KVKKCFSEIRSRFP--IGSQKALERWP 406
D D+ + E L +SL +++L + ++++ S R ++ + + + L+R
Sbjct: 112 ASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQR-- 169
Query: 407 STSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVL 466
E++ L + Q+ S +A+ L ++ Q D + + LQ E D L
Sbjct: 170 ------EKKKLQGILSQSQDKSLRRIAE--LREELQMDQQAKK--HLQEEFDAS-----L 214
Query: 467 EEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQS 526
EE KD+ ++V +T+ K N P D L P Q + ++
Sbjct: 215 EE-----------KDQYISVLQTQVSLLKQRLRNGPMNV-DVLKPLPQLEPQAEVFTKEE 262
Query: 527 QPHSKSR--VQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDA 584
P S V+ T L+ +Q VK ++ T +C K + ++
Sbjct: 263 NPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQ 322
Query: 585 TKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWL 644
E LQ+ + ++ H+ AE +K + +L + AK + +Q +
Sbjct: 323 LDERLQELEKIKDLHM---------------AEKTKLITQLRD--AKNLIEQLEQDKGMV 365
Query: 645 DAETSRRTKELNELKAEEM----YRLQQLSVSATHL---ADKVEEAVLDRLKPLLVKAQR 697
AET R+ E E+K EE+ R++Q++ L +K E A + L+ L AQ+
Sbjct: 366 IAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK 425
Query: 698 VNSTTEANIHLKD--GSSVNTAKAQPAQEVAAVDFESNNIRQ-LDDFLEDCASELWAVTH 754
T EA LK + T + +E ++ E + ++Q + D ++ + E +
Sbjct: 426 ---TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE--QIAK 480
Query: 755 AKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQ-ESVRQRYNKIAYADPRLWMQEENN 813
+ L + LA E + L+ R +E K E + Y KI+ +E
Sbjct: 481 LQKLHEKELARKEQEL-TKKLQTREREFQEQMKVALEKSQSEYLKIS---------QEKE 530
Query: 814 DQKISAISEKPLSPHPI 830
Q+ A+ E L I
Sbjct: 531 QQESLALEELELQKKAI 547
Score = 40.4 bits (93), Expect = 0.008
Identities = 115/583 (19%), Positives = 217/583 (37%), Gaps = 105/583 (18%)
Query: 218 EVQRLQKELSSCI---HKIEEVTK---------KDRLEEALDPDE------------ERR 253
E++ L ELS + HK+EE K LE +D + E
Sbjct: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE 744
Query: 254 IRIRRQEQAARSA-----RMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHR 308
+ I+R E+A + +L + +KE Q ++ L K+S + A+A
Sbjct: 745 VSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD----IKRSEGELQQASAKL 800
Query: 309 GAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKL-DADPSVPDV-------- 359
++ Q + T E L ++L L + L + ++ + + DV
Sbjct: 801 DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHK 860
Query: 360 --VIDILQQIEALESLLEKKLSPKKVKKCFSEIRSRFPIGSQKA---------LERWPST 408
V D++QQ+E S +E+K VK S+ G+++ E
Sbjct: 861 IQVQDLMQQLEKQNSEMEQK-----VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915
Query: 409 SPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEE 468
+G+++ + + Q+ S + +L ++Y+ + E + + + + L++
Sbjct: 916 MREGQKKEI---EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
Query: 469 GPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKA----ERGR 524
+LDQ A K E+ A + K+K K +A A G+ A E +
Sbjct: 973 K--LLDQEAKLKKELENTALELSQKEKQFNA-----KMLEMAQANSAGISDAVSRLETNQ 1025
Query: 525 QSQPHSKSRVQQTTVSSRL-----KMNRQPVKDRKAPWIPPNPTSPPASP---------- 569
+ Q S + V + ++ + K+N+Q + ++ I +
Sbjct: 1026 KEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGC 1085
Query: 570 ------KCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEA---ARLAWLDAETSK 620
K WLK + +D T LQ++ Q+ +H+ + E A L L+ + +K
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNK 1145
Query: 621 RLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKV 680
LKE L+ + ++ L L E R+ EL Q L S +
Sbjct: 1146 SLKENTFLQEQLVE------LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL 1199
Query: 681 EEAVLDRLK---PLLVKAQRVNSTTEANIHLKDGSSVNTAKAQ 720
E+ L+ K L ++ TEA + K +N + ++
Sbjct: 1200 EDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSK 1242
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 47.8 bits (112), Expect = 5e-05
Identities = 44/217 (20%), Positives = 97/217 (44%), Gaps = 12/217 (5%)
Query: 617 ETSKRLKELEELKAKEIDSMQKQR-LDWLDAETSRRTKELNELKAEEMYRLQQLSVSATH 675
E ++++E EE ++ + M++Q + W E RR +E+ K E+M R +++
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 377
Query: 676 LADKVEEAVLDR---LKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFES 732
+ EE + ++ ++ L K E ++ + + + QE A + +
Sbjct: 378 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE-AKMWRQE 436
Query: 733 NNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDL---EIMMRRMEEMEKYQ 789
IR+ ++ + + ++W KI E + E ++ ++ E + EE+ + +
Sbjct: 437 EKIREQEEKIREQEKKMWR-QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 790 ESVRQRYNKIAYADPRLWMQEE---NNDQKISAISEK 823
E + ++ KI + ++W QEE ++KI EK
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEK 532
Score = 41.2 bits (95), Expect = 0.005
Identities = 42/227 (18%), Positives = 100/227 (44%), Gaps = 12/227 (5%)
Query: 590 QQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQR-LDWLDAET 648
Q+E +E+ E + R + E ++++ EE+ ++ + M++Q + W E
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 378
Query: 649 SRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHL 708
RR +E+ K E++ L++ H +K+ E R + ++ Q EA +
Sbjct: 379 MRRQEEMMWEKEEKIRELEE----KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 434
Query: 709 KDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDCA----SELWAVTHAKILGSETLA 764
++ + + + ++ + + I + + E+ E+W KI E +
Sbjct: 435 QE-EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR-QEEKIHEQEEIW 492
Query: 765 TVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEE 811
++ + E + ++ E++ + +E +R++ KI + ++W QEE
Sbjct: 493 RQKEKMHEQE-EKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEE 538
Score = 36.2 bits (82), Expect = 0.15
Identities = 128/728 (17%), Positives = 286/728 (39%), Gaps = 90/728 (12%)
Query: 116 HIKEHHLRSQPQSSQKCGHTKYKIPDHRVERKESKSQAACQCSHQPSKVEISSSGAKVYL 175
H+ H + S+ K K ++ DH + S AA K +I++
Sbjct: 44 HLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTK----KKKINNG------ 93
Query: 176 YSSHPGQSDLTVPNSPPTHDPGLQPHPRIGDHKNISEQKSLLEVQR-LQKELSSCIHKIE 234
+P T G G H EQK+ + Q L++EL + +H I
Sbjct: 94 -------------TNPETTTSG-------GCHSPEDEQKASHQHQEALRRELEAQVHTIR 133
Query: 235 EVT-KKDRLEEALDPDEERRIRIRRQEQAARSA-RMLYVLQQQVKEIQEELDKLSPHKIK 292
+T +K L+ AL + +++ E AR L+ + E+++ L ++ K K
Sbjct: 134 ILTCQKTELQMALYYSQHA---VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKK 190
Query: 293 HTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDA 352
+ ++K R A+ +L+++ TD A+ +E L+ ++L+
Sbjct: 191 ADRYIEELTK----ERDAL-SLELYRNTITDEELKEKNAKLQEKLQLVES-EKSEIQLN- 243
Query: 353 DPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIRS-RFPIGSQ-KALERWPSTSP 410
V ++ +++E + LL ++ + E++S + +Q + E W +
Sbjct: 244 -------VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ 296
Query: 411 KGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGP 470
+ E + ++ + + ++ + ++ + E E R Q E+ + + +
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356
Query: 471 FILDQSASFK--DEVLAVAKTKAGKKKPVTENVPFRKKDTLAPAR-----QQGLRKAERG 523
+ ++ + +E++ + K ++ E + + K++ + Q+ +R+ E
Sbjct: 357 MMWEKEEKMRRQEEMMWEKEEKMRRQ----EEMMWEKEEKIRELEEKMHEQEKIREQEEK 412
Query: 524 RQSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRD 583
RQ + K R Q+ KM RQ K R+ + W + +
Sbjct: 413 RQEE--EKIREQEKRQEQEAKMWRQEEKIREQE-------EKIREQEKKMW---RQEEKI 460
Query: 584 ATKEPLQQEDPQEESHLTGAVE---HEAARLAWLDAETSKRLKELEELKAKEIDSMQKQR 640
+E +++E+ ++E E HE + W E ++ E EE K+ + + +Q
Sbjct: 461 HEQEKIREEEKRQEQEEMWRQEEKIHEQEEI-WRQKE---KMHEQEEKIRKQEEKVWRQE 516
Query: 641 LDWLDAETSRRTKELNELKAEEMYRLQQ---LSVSATHLADKV--EEAVLDRLKPLLVKA 695
+ E R +E + EE R Q+ H +K+ EE ++ + +
Sbjct: 517 EKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE 576
Query: 696 QRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHA 755
+++ E ++ K Q +E + + IR+ ++ +++ ++
Sbjct: 577 EKIREQEEKVWRQEEKIREQEEKRQEQEE--KMWKQEEKIREQEEKIQEQEEKI-REQEE 633
Query: 756 KILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEENNDQ 815
KI E + ++ K E M + E+M++ +E++ ++ KI + ++ QEE +
Sbjct: 634 KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIRE 693
Query: 816 KISAISEK 823
+ + E+
Sbjct: 694 QEEMMQEQ 701
Score = 35.0 bits (79), Expect = 0.34
Identities = 41/224 (18%), Positives = 94/224 (41%), Gaps = 16/224 (7%)
Query: 590 QQEDPQEESHLTGAVE--HEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAE 647
Q+E +E+ + E HE ++ W E KR ++ +++ +E +++ W E
Sbjct: 536 QEEKIREQEEMWREEEKMHEQEKI-W---EEEKRQEQEDKMWRQEEKIREQEEKVWRQEE 591
Query: 648 TSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIH 707
R +E + + E+M++ ++ + EE + ++ + + + + E
Sbjct: 592 KIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGE 651
Query: 708 LKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVE 767
++ K Q +E + + IR+ + + + KI E + +
Sbjct: 652 QEEKMCEQEEKMQEQEET--MWRQEEKIREQEKKIRE--------QEEKIREQEEMMQEQ 701
Query: 768 DSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEE 811
+ K E M + E+M++ +E +R++ K+ + RL QEE
Sbjct: 702 EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 745
Score = 33.1 bits (74), Expect = 1.3
Identities = 52/218 (23%), Positives = 91/218 (41%), Gaps = 24/218 (11%)
Query: 633 IDSMQKQRLDWLDAETSRRT---KELNELKAEEMYRLQQLSVSATHLADKVEEAV--LDR 687
I+ + K+R D L E R T +EL E A+ +LQ + + + V+E L+R
Sbjct: 195 IEELTKER-DALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER 253
Query: 688 LKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDCAS 747
K LL + Q EA+ K+ SV+ AK Q E + N ++ + ++
Sbjct: 254 AKLLLPQQQL---QAEADHLGKELQSVS-AKLQAQVEENELWNRLNQQQEEKMWRQEEKI 309
Query: 748 ELWAVT----HAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYAD 803
+ W KI E ++ K E+M + E+M + +E + ++ K+ +
Sbjct: 310 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 369
Query: 804 PRLWMQEE----------NNDQKISAISEKPLSPHPIR 831
+W +EE ++KI + EK IR
Sbjct: 370 EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR 407
>gi|11067749 bromodomain containing protein 3 [Homo sapiens]
Length = 726
Score = 44.7 bits (104), Expect = 4e-04
Identities = 65/306 (21%), Positives = 120/306 (39%), Gaps = 23/306 (7%)
Query: 494 KKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKDR 553
K P+ + RK D QG R S + + V+ K+ Q V +
Sbjct: 353 KHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKL--QDVFEM 410
Query: 554 KAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAW 613
+ +P P PA P AA + K + + E + +S E A RLA
Sbjct: 411 RFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSE-----EERATRLAE 465
Query: 614 LDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSA 673
L + ++L L ++ +K++ + + E ++ KE K +E ++++
Sbjct: 466 LQEQLKAVHEQLAALSQAPVNKPKKKK-EKKEKEKKKKDKE----KEKEKHKVKAEEEKK 520
Query: 674 THLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESN 733
+A ++A + A++ NSTT A LK G +A +E + +
Sbjct: 521 AKVAPPAKQAQQKK-----APAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYD 575
Query: 734 NIRQLD-DFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLE---IMMRRMEEMEKYQ 789
RQL D +L V H I+ S + + + D +++ + + E+E+Y
Sbjct: 576 EKRQLSLDINRLPGEKLGRVVH--IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYV 633
Query: 790 ESVRQR 795
+S Q+
Sbjct: 634 KSCLQK 639
>gi|4504063 golgin 97 [Homo sapiens]
Length = 767
Score = 44.3 bits (103), Expect = 6e-04
Identities = 110/523 (21%), Positives = 219/523 (41%), Gaps = 101/523 (19%)
Query: 223 QKELSSCIHKIEEVTKKDRLEEALDPDEERRIR--IRRQEQAARSARMLYVLQQQVKEIQ 280
Q+ELS H + KK+ ++ + E R R R QE+ S +M L Q+++E+Q
Sbjct: 178 QQELSKIKHML---LKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQ 234
Query: 281 EE---LDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELG 337
L++ H I K+ A SK+ A L + +EL
Sbjct: 235 RHYSTLEEQRDHVI--ASKTGAESKITA-----------------------LEQKEQELQ 269
Query: 338 SLIRQLSLCSVKLDAD-PSVPDVVIDILQQIEALESLLEKKLSPKK-VKKCFSE--IRSR 393
+LI+QLS+ K+ A+ DV+ + +++ +LE LE+ LS ++ V++ E + +
Sbjct: 270 ALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQ 329
Query: 394 FPIGSQKALERWPSTSPKG----ERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPE 449
+++ L S+ K E R + T + +K ++A + +T++ E
Sbjct: 330 NLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQ---ETQIQE 386
Query: 450 TQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTL 509
E + + E F L+++ + + +++A+ +T+A +
Sbjct: 387 LAAANQESSHVQQQALALEQQF-LERTQALEAQIVALERTRAADQ--------------- 430
Query: 510 APARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASP 569
+QG+R+ E+ + ++ +++ L+ ++ +K K W S
Sbjct: 431 -TTAEQGMRQLEQENAALKECRNEYERS-----LQNHQFELKKLKEEWSQREIVSV---- 480
Query: 570 KCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELK 629
A + L++ Q E + +AA L + E + L+E E+
Sbjct: 481 --------------AMAQALEEVRKQREE-----FQQQAANLTAIIDEKEQNLREKTEVL 521
Query: 630 AKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQL-SVSATHLADKVEEAVLDRL 688
+ ++Q + L+ + ++++L+AE L+ L ++ A A E+ L RL
Sbjct: 522 LQ-----KEQEILQLERGHNSALLQIHQLQAE----LEALRTLKAEEAAVVAEQEDLLRL 572
Query: 689 K-PLLVKAQRVNSTTEANIHLKDG-SSVNTAKAQPAQEVAAVD 729
+ PL +A VN + + ++D + TA P EV A+D
Sbjct: 573 RGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMD 615
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 43.5 bits (101), Expect = 0.001
Identities = 142/664 (21%), Positives = 254/664 (38%), Gaps = 102/664 (15%)
Query: 208 KNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSAR 267
K E + LL QR+ E+VT+K+ ++ DP E + + QE R
Sbjct: 1024 KGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQ-QLQEDHQR--- 1079
Query: 268 MLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEH 327
Q Q++E QEE K+K +K AM++ + ++ + T+
Sbjct: 1080 -----QDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATE------- 1127
Query: 328 PLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVK--- 384
+E+ L RQ + K A ++L++I ALE K + +KV+
Sbjct: 1128 ------REVSDLTRQYEDEAAKARASQREK---TELLRKIWALEEENAKVVVQEKVREIV 1178
Query: 385 ----KCFSEIRS-RFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLAD 439
K SE+ + R + Q+ R + + L A + V K+++
Sbjct: 1179 RPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKY 1238
Query: 440 KYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTK--AGKKKPV 497
K P+ E E QRL+ E ++D ++E + Q K E+ A+ TK K+ V
Sbjct: 1239 KTDPEME-KELQRLREE--IVDKTRLIERCDLEIYQ---LKKEIQALKDTKPQVQTKEVV 1292
Query: 498 TENVPFRK----KDTLAPAR------QQGLRKAERGRQSQPHSKSRVQQTTVSSRLK--- 544
E + F++ K+ +A R Q+ ER R SQ +R ++ SR+K
Sbjct: 1293 QEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEEL--SRVKERV 1350
Query: 545 MNRQPVKDRKAPWIPPNPTSPPAS--------PKCAAWLKVKTSPRDATKEPLQQEDPQE 596
+ ++ V+ + P + ++ S K A +++ R T+ Q E+ +
Sbjct: 1351 VQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRA--ELRRLQRRRTELERQLEELER 1408
Query: 597 ESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELN 656
E E E RL + E EE +A+E + ++ + D + +R L
Sbjct: 1409 ERQARREAEREVQRL-----QQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLR 1463
Query: 657 ELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNT 716
EE +R Q L E L+ L+ L ++ E + SV
Sbjct: 1464 LQLEEEQHRRQLL------------EGELETLRRKLAALEK----AEVKEKVVLSESVQV 1507
Query: 717 AKAQPAQEV----AAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSK-- 770
K QE+ ++++ ES + R+LD + + L + S+ L + +
Sbjct: 1508 EKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHK 1567
Query: 771 ---DSPDLEIMMRRMEEMEKYQESVRQRYNKIAYA------DPRLWMQEENNDQKISAIS 821
+ +L++ RR++ + + + A D RLW E D
Sbjct: 1568 LQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSK 1627
Query: 822 EKPL 825
+K L
Sbjct: 1628 DKDL 1631
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 42.7 bits (99), Expect = 0.002
Identities = 140/655 (21%), Positives = 261/655 (39%), Gaps = 82/655 (12%)
Query: 205 GDHKNISEQKSL-LEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAA 263
G I ++++L +++Q+ KEL + I ++EE + + ER R + ++Q +
Sbjct: 1093 GLQSKIEDEQALGMQLQKKIKELQARIEELEE-----------EIEAERASRAKAEKQRS 1141
Query: 264 RSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWA-MSKLAAAHRGAIRALQMFVTQFT 322
+R L +++ E EE + +I+ KK A K+ A LQ T T
Sbjct: 1142 DLSREL----EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEA--TLQHEATAAT 1195
Query: 323 DRGEHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQ-----------QIEALE 371
R +H ELG I L KL+ + S + ID L +E +
Sbjct: 1196 LRKKH--ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMC 1253
Query: 372 SLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPS 431
LE +LS K K+ E + R I A T R L KDT + SR
Sbjct: 1254 RALEDQLSEIKTKE---EEQQRL-INDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGK 1309
Query: 432 VA--KQLLADKYQPDTELPETQRLQSELDVL--DADIVLEEGPFILDQSASFKDEVLAVA 487
A +Q+ K Q + E+ L L D D++ E+ +++E A A
Sbjct: 1310 QAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQ----------YEEEQEAKA 1359
Query: 488 KTKAGKKKPVTENVPFRKK-DTLAPARQQGLRKAERG-RQSQPHSKSRVQQTTVS-SRLK 544
+ + K +E +R K +T A R + L +A++ Q ++ V+ + L+
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLE 1419
Query: 545 MNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAV 604
+Q +++ + + A CAA + R+ K + + EE+H
Sbjct: 1420 KTKQRLQNEVEDLMIDVERTNAA---CAA---LDKKQRNFDKILAEWKQKCEETHAELEA 1473
Query: 605 EHEAAR-----LAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLD--AETSRRTKELNE 657
+ +R L + + L +LE LK +E ++Q++ D + AE +R EL +
Sbjct: 1474 SQKESRSLSTELFKIKNAYEESLDQLETLK-RENKNLQQEISDLTEQIAEGGKRIHELEK 1532
Query: 658 L-------KAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKD 710
+ K+E L++ S H K+ L+ L + + R + + I
Sbjct: 1533 IKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE-LNQVKSEVDRKIAEKDEEIDQMK 1591
Query: 711 GSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDS- 769
+ + ++ + A + ++ IR D + HA + +E L ++
Sbjct: 1592 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1651
Query: 770 ---KDSP-DLEIMMRRMEEMEKYQESVRQRYN--KIAYADPRLWMQEENNDQKIS 818
KD+ L+ +R E++++ V +R N + + R +++ +KI+
Sbjct: 1652 AILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1706
Score = 36.6 bits (83), Expect = 0.12
Identities = 61/248 (24%), Positives = 100/248 (40%), Gaps = 43/248 (17%)
Query: 567 ASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELE 626
A +C +K K KE ++ + +EE + A L A+ K E
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEIN------------AELTAKKRKLEDECS 952
Query: 627 ELKAKEIDSMQKQRLDWLDAETSRRTKELNELK--AEEMYRLQQLSVSATHLADKVEEAV 684
ELK K+ID ++ L E + E N++K EEM L + T ++EA
Sbjct: 953 ELK-KDIDDLE---LTLAKVEKEKHATE-NKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1007
Query: 685 LDRLKPLLVKAQRVNSTTEANIHLK------DGSSVNTAKAQPAQEVAAVDFE------- 731
L L + +VN+ T+A I L+ +GS K + E A E
Sbjct: 1008 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQ 1067
Query: 732 ------SNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEM 785
N+ +QLD+ L+ E+ + +KI + L K ++ + R+EE+
Sbjct: 1068 ESTMDIENDKQQLDEKLKKKEFEMSGL-QSKIEDEQALGMQLQKK----IKELQARIEEL 1122
Query: 786 EKYQESVR 793
E+ E+ R
Sbjct: 1123 EEEIEAER 1130
Score = 33.5 bits (75), Expect = 0.99
Identities = 28/101 (27%), Positives = 50/101 (49%), Gaps = 9/101 (8%)
Query: 211 SEQKSLLEVQRLQKELSSCIHKI---EEVTKKDRLEEALDPDEERRIRIRRQEQAARSAR 267
+++K ++ ++Q E+ I + EE KK + A+ +E ++ Q+ +A R
Sbjct: 1730 TKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKK----EQDTSAHLER 1785
Query: 268 MLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHR 308
M L+Q VK++Q LD+ +K KK + KL A R
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQ--IQKLEARVR 1824
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 42.4 bits (98), Expect = 0.002
Identities = 135/687 (19%), Positives = 266/687 (38%), Gaps = 107/687 (15%)
Query: 192 PTHDPGLQPHPRIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEE 251
P PG++ H ++ + +++RL++EL K ++L + E+
Sbjct: 234 PCGSPGMK-RTESRQHLSVELADAKAKIRRLRQELEE---------KTEQLLDCKQELEQ 283
Query: 252 RRIRIRRQEQA-------ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLA 304
I ++R +Q ARSARM ++E +DKL ++ ++ +
Sbjct: 284 MEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYK 343
Query: 305 AAHRGAIRALQMFV---TQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVI 361
A Q+ + T D+ E AR +L L ++ KL D+ +
Sbjct: 344 ARVEELKEDNQVLLETKTMLEDQLEGTR-ARSDKLHELEKENLQLKAKLH------DMEM 396
Query: 362 DILQQIEALESLLEKKLSPKKVKKCFSEIRSRF-----PIGSQKALERWPSTSPKGERRP 416
+ + +E L+E+ ++ + +K + I L P S E
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
Query: 417 LTAKDTFPQETSRPSVAKQL-----LADKYQPDTEL-----PETQRLQSELDVLDADIVL 466
LT+ E S+ K + D + + E QRL ++++L+ +IV
Sbjct: 457 LTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ 516
Query: 467 EEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQS 526
E+ Q+ S KD + K KA +K + +TL ++ ++ E+ +
Sbjct: 517 EKQSLQNCQNLS-KD----LMKEKAQLEKTI---------ETLRENSERQIKILEQENEH 562
Query: 527 QPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATK 586
+ S ++Q + S + K+ K TS S K++ R K
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS-------KIEFEKRQIKK 615
Query: 587 EPLQQEDPQEESH-LTGAVEH-----------------EAARLAWLDAETSKRLKELEEL 628
E ++ E + L + H ++ L+ E S+ +E +L
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 629 KAKEIDSMQKQ--RLDWLDAETSRRTKELNELKAE-EMYRLQQLSVSATHLADKVEEAVL 685
K K +DS + +L+ L+ E S+ +E EL+ E + + ++ L +K E+
Sbjct: 676 K-KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 686 DRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDC 745
++LK L + TE G + + Q E + + I+QL+ L+D
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS-----NKKIQQLESELQDL 789
Query: 746 ASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
E ++TL K+ +L+I +R+E++EK +S+ Q +++ D +
Sbjct: 790 EME-----------NQTL-----QKNLEELKISSKRLEQLEKENKSLEQETSQLE-KDKK 832
Query: 806 LWMQEENNDQKISAISEKPLSPHPIRI 832
+E ++ + I + L + ++I
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKI 859
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 42.4 bits (98), Expect = 0.002
Identities = 135/687 (19%), Positives = 266/687 (38%), Gaps = 107/687 (15%)
Query: 192 PTHDPGLQPHPRIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEE 251
P PG++ H ++ + +++RL++EL K ++L + E+
Sbjct: 234 PCGSPGMK-RTESRQHLSVELADAKAKIRRLRQELEE---------KTEQLLDCKQELEQ 283
Query: 252 RRIRIRRQEQA-------ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLA 304
I ++R +Q ARSARM ++E +DKL ++ ++ +
Sbjct: 284 MEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYK 343
Query: 305 AAHRGAIRALQMFV---TQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVI 361
A Q+ + T D+ E AR +L L ++ KL D+ +
Sbjct: 344 ARVEELKEDNQVLLETKTMLEDQLEGTR-ARSDKLHELEKENLQLKAKLH------DMEM 396
Query: 362 DILQQIEALESLLEKKLSPKKVKKCFSEIRSRF-----PIGSQKALERWPSTSPKGERRP 416
+ + +E L+E+ ++ + +K + I L P S E
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
Query: 417 LTAKDTFPQETSRPSVAKQL-----LADKYQPDTEL-----PETQRLQSELDVLDADIVL 466
LT+ E S+ K + D + + E QRL ++++L+ +IV
Sbjct: 457 LTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ 516
Query: 467 EEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQS 526
E+ Q+ S KD + K KA +K + +TL ++ ++ E+ +
Sbjct: 517 EKQSLQNCQNLS-KD----LMKEKAQLEKTI---------ETLRENSERQIKILEQENEH 562
Query: 527 QPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATK 586
+ S ++Q + S + K+ K TS S K++ R K
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS-------KIEFEKRQIKK 615
Query: 587 EPLQQEDPQEESH-LTGAVEH-----------------EAARLAWLDAETSKRLKELEEL 628
E ++ E + L + H ++ L+ E S+ +E +L
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 629 KAKEIDSMQKQ--RLDWLDAETSRRTKELNELKAE-EMYRLQQLSVSATHLADKVEEAVL 685
K K +DS + +L+ L+ E S+ +E EL+ E + + ++ L +K E+
Sbjct: 676 K-KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 686 DRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDC 745
++LK L + TE G + + Q E + + I+QL+ L+D
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS-----NKKIQQLESELQDL 789
Query: 746 ASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
E ++TL K+ +L+I +R+E++EK +S+ Q +++ D +
Sbjct: 790 EME-----------NQTL-----QKNLEELKISSKRLEQLEKENKSLEQETSQLE-KDKK 832
Query: 806 LWMQEENNDQKISAISEKPLSPHPIRI 832
+E ++ + I + L + ++I
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKI 859
>gi|156104874 envoplakin [Homo sapiens]
Length = 2033
Score = 42.4 bits (98), Expect = 0.002
Identities = 132/700 (18%), Positives = 273/700 (39%), Gaps = 129/700 (18%)
Query: 206 DHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEE---RRIRIRRQEQA 262
+ K ++ + LE QR Q +E + +K+ +E DP E R++ + +E+
Sbjct: 924 ERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEG 983
Query: 263 ARSARM---LYVLQQQVKEIQEELDKLSPH----KIKHTKKSWAMSKLAAAHRGAIRALQ 315
R A + L V Q+V +++ + + PH ++ ++ + AA R I+ L
Sbjct: 984 KRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQL- 1042
Query: 316 MFVTQFTDRGEHP-LPARCKELGSLIRQLSLCSVKLDADPSVPDVV-----IDILQQIEA 369
RGE + AR + L + L V + V +VV +++++ +A
Sbjct: 1043 --------RGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQA 1094
Query: 370 LESLLEKKLSPKK---------------VKKCFSEIRSRFPIGSQKALERWPSTSPKGER 414
L +E+ + +K +++ S + + + K +E+ P + R
Sbjct: 1095 LRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSR 1154
Query: 415 RPLTAKDTFPQETSRPSVAKQL--------LADKYQPDTEL-----------PETQRLQS 455
++ + T ++A++L + +K +P +L PET++ +
Sbjct: 1155 LRSLLEE---ERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEIT 1211
Query: 456 ELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVP--------FRKKD 507
L ++ + + D + A+ + K VT+ V R+ D
Sbjct: 1212 RLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREID 1271
Query: 508 TLAPA----------RQQGLRKAERGRQSQPHSKSRVQQTTVSSRL-KMNRQPVKDRKAP 556
L Q+ L + + R +++V+ TVS + + + PV +++A
Sbjct: 1272 RLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAE 1331
Query: 557 WIPPNPTSPPASPKCAA----------WLKVKTSPRDAT---KEPLQQEDP---QEESHL 600
+ + A L + P + + + Q+DP +E S L
Sbjct: 1332 RLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRL 1391
Query: 601 TGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKA 660
+G+++ E R L+ E + +EE + + S Q+ R L E +EL +L
Sbjct: 1392 SGSLDEEVGRRRQLELEVQQLRAGVEEQEG--LLSFQEDRSKKLAVE-----RELRQL-- 1442
Query: 661 EEMYRLQQLSVSATHLADKV--EEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAK 718
R+Q+L + +K+ EE V L K + +TEA +
Sbjct: 1443 --TLRIQELEKRPPTVQEKIIMEEVV------KLEKDPDLEKSTEA---------LRWDL 1485
Query: 719 AQPAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIM 778
Q +V ++ E N++ D L+ S+ + + +++ + +ED + + E++
Sbjct: 1486 DQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTI-YKEVIRVQKDRVLEDER-ARVWEML 1543
Query: 779 MRRMEEMEKYQESVRQRYNKIAYADP--RLWMQEENNDQK 816
R + +E R+ +I A+ R W +EE+ Q+
Sbjct: 1544 NRERTARQAREEEARRLRERIDRAETLGRTWSREESELQR 1583
Score = 40.8 bits (94), Expect = 0.006
Identities = 81/388 (20%), Positives = 152/388 (39%), Gaps = 42/388 (10%)
Query: 515 QGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQ--------PVKDRKAPWIPPNPTSPP 566
Q ++ ER R + H +Q L+ + V K P + P S
Sbjct: 795 QEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ 854
Query: 567 ASPK--CAAWLKVKTSPR------DATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAET 618
A K A+ +V + + + ++ L++++ E+ T + + A E+
Sbjct: 855 AQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRES 914
Query: 619 SKRLKELEELK---AKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATH 675
+LEE + A+ ++ QR L T R + L E + E YR QL S +
Sbjct: 915 EALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSR 974
Query: 676 LADKVEE---------AVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVA 726
+ +VEE A L+ +V+ + T + ++ K+ + V +Q A
Sbjct: 975 VKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQ-AA 1033
Query: 727 AVDFESNNIRQLDDF----LEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRM 782
+ + +R D LE EL A+ ++ E + E K +LE M++
Sbjct: 1034 QLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLE-MVKAA 1092
Query: 783 EEMEKYQESVRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPA 842
+ + E R + A +L + E+ ++ IS++ K + ++ K V+ +DP
Sbjct: 1093 QALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVI----VKEVKKVE-QDPG 1147
Query: 843 VNIMLERPCNGNSLDESVGTEEGSEKRE 870
+L+ SL E T+ + RE
Sbjct: 1148 ---LLQESSRLRSLLEEERTKNATLARE 1172
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 42.0 bits (97), Expect = 0.003
Identities = 141/718 (19%), Positives = 274/718 (38%), Gaps = 112/718 (15%)
Query: 210 ISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARML 269
++E+K L LQ+E+ + + E+ + E+ E++ + +E+ + +
Sbjct: 328 VAERK--LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH----I 381
Query: 270 YVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPL 329
LQ+ +E+Q D L K L + A+++ Q + Q D+ L
Sbjct: 382 LSLQKTGQELQSACDALKDQNSK---------LLQDKNEQAVQSAQT-IQQLEDQ----L 427
Query: 330 PARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSE 389
+ KE+ + +L L + + S PDV E +++ E+ ++ + + E
Sbjct: 428 QQKSKEISQFLNRLPLQQHETASQTSFPDVYN------EGTQAVTEENIASLQKRVVELE 481
Query: 390 IRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPE 449
+ S LE K E L+++ T + +R E
Sbjct: 482 NEKGALLLSSIELEEL-----KAENEKLSSQITLLEAQNRTG-----------------E 519
Query: 450 TQRLQSELDVLD-----ADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFR 504
R SE+ ++D + E G +L+ + S K + L+V + K E + F
Sbjct: 520 ADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEM---KEAQEEIAFL 576
Query: 505 KKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKD--RKAPWIPPNP 562
K + QG R E + + + + + +KM + ++D + P +P
Sbjct: 577 K------LQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKM-KVFLEDTGQDFPLMPNEE 629
Query: 563 TSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRL 622
+S PA K A T + T E + D E T + K L
Sbjct: 630 SSLPAVEKEQA----STEHQSRTSEEISLNDAGVELKST-------------KQDGDKSL 672
Query: 623 KELEELKAKEIDSMQKQRLDWLDAETS-RRTKELNEL----KAEEMYRLQQLSVSATHLA 677
+ ++ D +++ + L+ E + + +E+ E KA+E+ L QL A
Sbjct: 673 SAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNA 732
Query: 678 DKVEEA---VLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNN 734
D A + + LL + + ++ TE +K +N A+A+ + + D+ES
Sbjct: 733 DNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQ-LEMNLAEAERQRRL---DYESQT 788
Query: 735 IRQLDDFLEDCASELWAVTHAKILGSETLATVED------SKDSPDLEIMMRRMEEMEKY 788
D+ L + L +K + E L D S+ S + + +++ E
Sbjct: 789 AH--DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESE 846
Query: 789 ----QESVRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVN 844
E VR +K+ L +E + + EK ++ +T++ KD V
Sbjct: 847 VLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQ--QTIEEKDQQVT 904
Query: 845 ----IMLERPCNGNSLDESVGTEEGSEKREAPLLSLAEDSQQKEGRAPLFVPPGMQHS 898
M E+ N S+G E + K + LLS AE++++++ V G++ +
Sbjct: 905 EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQN 962
Score = 41.6 bits (96), Expect = 0.004
Identities = 105/535 (19%), Positives = 207/535 (38%), Gaps = 48/535 (8%)
Query: 203 RIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQA 262
R+ K I E K+ EVQ QK + + + + E +E R + Q +
Sbjct: 2256 RLEHDKQIWESKAQTEVQLQQK--------VCDTLQGENKELLSQLEETRHLYHSSQNEL 2307
Query: 263 ARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQF- 321
A+ L+ ++K ++++L LS K ++ + + I+ + Q
Sbjct: 2308 AK-------LESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLE 2360
Query: 322 TD-RGEHPLPARCKELGSLIRQ--LSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKL 378
TD + L +R E ++ Q +SL S K +A + + ++ QQ + LE L
Sbjct: 2361 TDLQASRELTSRLHEEINMKEQKIISLLSGKEEA---IQVAIAELRQQHDKEIKELENLL 2417
Query: 379 SPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLA 438
S ++ + E ++ KA+++ T+ E K+ Q+ S K + +
Sbjct: 2418 SQEEEENIVLEEENK------KAVDK---TNQLMETLKTIKKENIQQKAQLDSFVKSMSS 2468
Query: 439 DKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSAS---FKDEVLAVAK----TKA 491
+ D + + Q+L+ I+LE+ I + +A K+E+ + +
Sbjct: 2469 LQNDRDRIVGDYQQLEER----HLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS 2524
Query: 492 GKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVK 551
K E + +R+ + +K Q Q + + + + +LK + + +
Sbjct: 2525 ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE 2584
Query: 552 DRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAV-EHEAAR 610
D + + S + + LKV S LQ+E H V E E R
Sbjct: 2585 DLRRSFNALQEEKQDLSKEIES-LKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHR 2643
Query: 611 LAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLS 670
L+ L + + KR+ ELEE E+ +QK+ + + KEL L + +
Sbjct: 2644 LSALFSSSQKRIAELEE----ELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETE 2699
Query: 671 VSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEV 725
+ +A+ + V K L+V + T + + SS+ ++ +E+
Sbjct: 2700 TAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL 2754
Score = 35.8 bits (81), Expect = 0.20
Identities = 111/511 (21%), Positives = 192/511 (37%), Gaps = 96/511 (18%)
Query: 210 ISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARML 269
IS +++L E + LQ+ELS IE +TK D E ++ + +E+ R L
Sbjct: 1490 ISRKEALKENKSLQEELSLARGTIERLTKSLA-------DVESQVSAQNKEKDTVLGR-L 1541
Query: 270 YVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPL 329
+LQ++ ++ E+D+ +++ S + L A G + V + +
Sbjct: 1542 ALLQEERDKLITEMDR---SLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKI 1598
Query: 330 PARC----------KELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI-------EALES 372
KE L++ S + + V + V Q++ EA +
Sbjct: 1599 AESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK 1658
Query: 373 LLEKKL--SPKKVKKCFSEIRSRFPIGSQKALERWPSTSP-KGERRPL--TAKDTFPQE- 426
EK+L + +++++ ++R QK LE + E P TAK+
Sbjct: 1659 ETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLL 1718
Query: 427 TSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAV 486
+S S+ ++L K + +T + Q L SE D L ++ D + V
Sbjct: 1719 SSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQ--------DLKHQIEGNVSKQ 1770
Query: 487 AKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMN 546
A +A +K NV E G QS P +T L M+
Sbjct: 1771 ANLEATEKHDNQTNV------------------TEEGTQSIPG------ETEEQDSLSMS 1806
Query: 547 RQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEH 606
+P +P ++ PA K S D LQQ D +E
Sbjct: 1807 TRPTCSES---VPSAKSANPAVSK-------DFSSHDEINNYLQQIDQLKE--------- 1847
Query: 607 EAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKE------LNELKA 660
R+A L+ E K KE + E +++ Q + D E +E LN+
Sbjct: 1848 ---RIAGLEEEKQKN-KEFSQTLENEKNTLLSQ-ISTKDGELKMLQEEVTKMNLLNQQIQ 1902
Query: 661 EEMYRLQQLSVSATHLADKVEEAVLDRLKPL 691
EE+ R+ +L +A D +EE ++++L L
Sbjct: 1903 EELSRVTKLKETAEEEKDDLEERLMNQLAEL 1933
Score = 35.8 bits (81), Expect = 0.20
Identities = 57/238 (23%), Positives = 103/238 (43%), Gaps = 38/238 (15%)
Query: 587 EPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKE------IDSMQKQR 640
E + ++ + S L+G E +A L + K +KELE L ++E ++ K+
Sbjct: 2375 EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKA 2434
Query: 641 LDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNS 700
+D +T++ + L +K E + + QL ++ + DR+ + Q++
Sbjct: 2435 VD----KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDR--DRI---VGDYQQLEE 2485
Query: 701 TTEANIHLKDGSSVNTAKAQPAQEVAAVDFE-SNNIRQLDDFLEDCASELWAVTHAKILG 759
HL S+ K Q QE AA + + IR L ++D SE + I
Sbjct: 2486 R-----HL----SIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQY 2536
Query: 760 SETL---ATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEENND 814
E L T++DS+ LE+ +++ +E+E NK A + +L EE N+
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELE----------NKYAKLEEKLKESEEANE 2584
Score = 34.3 bits (77), Expect = 0.58
Identities = 112/570 (19%), Positives = 222/570 (38%), Gaps = 86/570 (15%)
Query: 213 QKSLLEVQRLQKELSSCIHKIEE-----VTKKDRLEEALDPDEERRIRIRRQEQAARSAR 267
+ LLE + K L C+ ++EE V +K ++E + + +I+ ++E +S
Sbjct: 1950 KNELLESE--MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHA 2007
Query: 268 MLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEH 327
LQ+ +KE Q+E+ +L I++ +K A+ + ++AL+ T+ +
Sbjct: 2008 K--ELQELLKEKQQEVKQLQKDCIRYQEKISALER-------TVKALEFVQTE----SQK 2054
Query: 328 PLPARCKELGSLIR-----QLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPK- 381
L + L + Q L S K+ D + + + ++ + L K S K
Sbjct: 2055 DLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKS 2114
Query: 382 KVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKY 441
++K+ ++ R +K L+ + K + L + +ET DK
Sbjct: 2115 QMKQKDEDLERRLEQAEEKHLKEKKNMQEKLD--ALRREKVHLEETIGEIQVTLNKKDK- 2171
Query: 442 QPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENV 501
E Q+LQ LD V + F S+ D + + K +
Sbjct: 2172 -------EVQQLQENLD----STVTQLAAFTKSMSSLQDDRDRVIDEAKKWE-------- 2212
Query: 502 PFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTV-SSRLKMNRQPVKDRKAPWIPP 560
RK ++++ +R E + K +++Q ++ LK+N ++ K W
Sbjct: 2213 --RKFSDAIQSKEEEIRLKE---DNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW--- 2264
Query: 561 NPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARL-----AWLD 615
A + KV + + KE L Q +E HL + ++E A+L + D
Sbjct: 2265 ---ESKAQTEVQLQQKVCDTLQGENKELLSQ--LEETRHLYHSSQNELAKLESELKSLKD 2319
Query: 616 --AETSKRLKELEELKAKEIDSMQKQRLDWLDAETS--------RRTKELNELKAEEMYR 665
+ S L++ +E K +++Q D +++ S + ++EL EE+
Sbjct: 2320 QLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
Query: 666 LQQLSVSATHLADKVEEAVLDRL-----KPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQ 720
+Q +S ++ + + L K + ++ E NI L++ + K
Sbjct: 2380 KEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTN 2439
Query: 721 PAQEVAAVDFESNNIR---QLDDFLEDCAS 747
E + NI+ QLD F++ +S
Sbjct: 2440 QLMETLKT-IKKENIQQKAQLDSFVKSMSS 2468
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/209 (21%), Positives = 97/209 (46%), Gaps = 13/209 (6%)
Query: 617 ETSKRLKELEELKAKEIDSM--QKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSV--- 671
E ++LK +EEL + + +++ L+ + E S TKE+ +LKA++ ++ S+
Sbjct: 739 EKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEE 798
Query: 672 --SATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQ---EVA 726
H D ++V + L+ L+K T + +I K N K + Q A
Sbjct: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKA 858
Query: 727 AVDFESNNIRQLDDFLEDCASELWAV-THAKILGSETLATVEDSKDSPDLEIMMRRME-E 784
++ + ++ +L+D E ++ H + + L + +LEI+++ E E
Sbjct: 859 VLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENE 918
Query: 785 MEKYQESVRQRYNKIAYADPRLW-MQEEN 812
+++ + +++R + ++ L +Q+EN
Sbjct: 919 LKRLEAMLKERESDLSSKTQLLQDVQDEN 947
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 41.2 bits (95), Expect = 0.005
Identities = 70/340 (20%), Positives = 138/340 (40%), Gaps = 64/340 (18%)
Query: 614 LDAETSKRLKELEELKAKEIDSMQK--QRLDWLDAETSRRTKELNE-------LKAEEMY 664
++++ K+ +EL ++K + +++ K Q AETS+R +L E + AE +
Sbjct: 845 MNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLS 904
Query: 665 RLQQLSVSATHLADKVE--EAVLDRLKPL-------LVKAQRVNSTTEANIHLKDGSSVN 715
L+ L DKVE +A + LK L + Q ++ T ++ K+ SS+
Sbjct: 905 ALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETL--SLEKKEMSSII 962
Query: 716 TAKAQPAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDL 775
+ + +E+ E+ +++++ L L I SE+ A D ++
Sbjct: 963 SLNKREIEELTQ---ENGTLKEINASLNQEKMNL-------IQKSESFANYIDEREKSIS 1012
Query: 776 E----------IMMRRMEEMEKYQESVRQRYNKIAYADPRL--WMQE-----ENNDQKIS 818
E I+++R EE E + Q+Y + +L + E EN ++
Sbjct: 1013 ELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELE 1072
Query: 819 AISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTEEGSEKREA-----PL 873
+ E H +TK ++ N+MLE +L + + + K EA +
Sbjct: 1073 QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEI 1132
Query: 874 LSLAEDSQQKEGRAPLFVPPGMQHSIGDYCSRFEQYLRII 913
++L E+ + MQ + D EQ ++++
Sbjct: 1133 MTLKEEQNK------------MQKEVNDLLQENEQLMKVM 1160
Score = 32.3 bits (72), Expect = 2.2
Identities = 51/232 (21%), Positives = 90/232 (38%), Gaps = 43/232 (18%)
Query: 606 HEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYR 665
H A +L + E ++E L+ + S + Q L LDAE S+ E + + EEM R
Sbjct: 2137 HIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMAR 2196
Query: 666 --------LQQLSVSATHLADKVEE--AVLDRLKPLLVKAQR-VNSTTEANIHLKDGSSV 714
L L +L +++E L L LL + + +A I +K+ S
Sbjct: 2197 SLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK- 2255
Query: 715 NTAKAQPAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSP- 773
AV+ N +++L++ + + E + E S D P
Sbjct: 2256 -----------TAVEMLQNQLKELNEAVAALCGD-----------QEIMKATEQSLDPPI 2293
Query: 774 --------DLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEENNDQKI 817
+E + R+E EK Q V Q+ + + L + EN ++++
Sbjct: 2294 EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL 2345
>gi|8923271 coiled-coil domain containing 49 [Homo sapiens]
Length = 425
Score = 41.2 bits (95), Expect = 0.005
Identities = 53/225 (23%), Positives = 90/225 (40%), Gaps = 27/225 (12%)
Query: 474 DQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLR-----KAERGRQSQP 528
D+S+S + ++ K PV VP R QGL+ + +RG +
Sbjct: 197 DRSSSEDEHSAGRSQKKMANSSPVLSKVPGYGLQVRNSDRNQGLQGPLTAEQKRGHGMKN 256
Query: 529 HSKSRVQQTTV---SSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDAT 585
HS+SR + +S+ +DR++ + SP S + KV T
Sbjct: 257 HSRSRSSSHSPPRHASKKSTREAGSRDRRSRSLGRRSRSPRPSKLHNS--KVNRRETGQT 314
Query: 586 KEPLQQEDPQEESHLTG------AVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQ 639
+ P +++ + H G A E E R ++ + + L LK D ++Q
Sbjct: 315 RSPSPKKEVYQRRHAPGYTRKLSAEELERKRQEMMENAKWREEERLNILKRHAKDEEREQ 374
Query: 640 RLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAV 684
RL+ LD SR K ++ +K E S S + L D+V+ +
Sbjct: 375 RLEKLD---SRDGKFIHRMKLE--------SASTSSLEDRVKRNI 408
Score = 30.4 bits (67), Expect = 8.4
Identities = 39/174 (22%), Positives = 69/174 (39%), Gaps = 7/174 (4%)
Query: 439 DKYQPDTELPETQRLQSELDVLDADIVLEEGP-FILDQSASFKDEVLAVAKTKAGKKKPV 497
DKY + + SE +L I G +LD ++ +++ L + + K +KK
Sbjct: 93 DKYVFEKMEEKEAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLFIIRKKEEEKKRE 152
Query: 498 TENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPW 557
N P + K + Q L K E+ ++ + K + + SS + + +
Sbjct: 153 VLNNPVKMK-KIKELLQMSLEKKEKKKKKEKKKKHKKHKHRSSSSDRSSSEDEHSAGRSQ 211
Query: 558 IPPNPTSPPASPKCAAWLKVKTSPRD-ATKEPLQQEDPQEESHLTGAVEHEAAR 610
+SP S L+V+ S R+ + PL E Q+ H G H +R
Sbjct: 212 KKMANSSPVLSKVPGYGLQVRNSDRNQGLQGPLTAE--QKRGH--GMKNHSRSR 261
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 40.8 bits (94), Expect = 0.006
Identities = 70/308 (22%), Positives = 122/308 (39%), Gaps = 43/308 (13%)
Query: 513 RQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCA 572
++ K E R + KS ++ + ++ Q D + A +C
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCD 906
Query: 573 AWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKE 632
+K K KE ++ + +EE + A L A+ K E ELK ++
Sbjct: 907 QLIKNKIQLEAKVKEMNERLEDEEEMN------------AELTAKKRKLEDECSELK-RD 953
Query: 633 IDSMQKQRLDWLDAETSRRTKELNELK--AEEMYRLQQLSVSATHLADKVEEAVLDRLKP 690
ID ++ L E + E N++K EEM L ++ T ++EA L
Sbjct: 954 IDDLE---LTLAKVEKEKHATE-NKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1009
Query: 691 LLVKAQRVNSTTEANIHLK------DGSSVNTAKAQPAQEVAAVDFE------------- 731
L + +VN+ T+A + L+ +GS K + E A E
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069
Query: 732 SNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQES 791
N+ +QLD+ L+ EL A+ +A+I + L + K L+ + R+EE+E+ E+
Sbjct: 1070 ENDKQQLDERLKKKDFELNAL-NARIEDEQALGSQLQKK----LKELQARIEELEEELEA 1124
Query: 792 VRQRYNKI 799
R K+
Sbjct: 1125 ERTARAKV 1132
Score = 38.1 bits (87), Expect = 0.040
Identities = 136/665 (20%), Positives = 243/665 (36%), Gaps = 94/665 (14%)
Query: 242 LEEALDPDEERRIRIRRQ---------EQAARSARMLYVLQQQVKEIQEELDKLSPHKIK 292
LEEA E +R++ EQ R+ L+++ E + ELD ++ + +
Sbjct: 1178 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1237
Query: 293 HTKKSWAMSKLAAA-------HRGAIRALQMFVTQFT--------DRGEHPLPARCKELG 337
K + K+ HR Q V T + GE L + E
Sbjct: 1238 IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGE--LSRQLDEKE 1295
Query: 338 SLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKK----VKKCFSEIRSR 393
+LI QL+ KL + D+ + ++++A +L S + +++ + E +
Sbjct: 1296 ALISQLT--RGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEE-ETE 1352
Query: 394 FPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPET--- 450
Q+ L + + S + R D Q T AK+ LA + Q E E
Sbjct: 1353 AKAELQRVLSK--ANSEVAQWRTKYETDAI-QRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 451 ---------QRLQSELDVLDADIVLEEGPFI-LDQSASFKDEVLAVAKTKAGKKKPVTEN 500
RLQ+E++ L D+ LD+ D++LA K K + + E+
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 501 VPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPP 560
++ E + + +S T K ++ + D
Sbjct: 1470 ----------SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL--- 1516
Query: 561 NPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSK 620
+S K L+ +A K LQ + E+ L EHE ++ E ++
Sbjct: 1517 -----GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL----EHEEGKILRAQLEFNQ 1567
Query: 621 RLKELEELKAKEIDSMQKQRLDW----------LDAETSRRTKELNELKAEEMYRLQQLS 670
E+E A++ + M++ + + LDAET R + L K E L ++
Sbjct: 1568 IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKME-GDLNEME 1626
Query: 671 VSATHLADKVEEA--VLDRLKPLLVKAQ-RVNSTTEANIHLKDGSSV----NTAKAQPAQ 723
+ +H EA + L+ LL Q +++ AN LK+ ++ N +
Sbjct: 1627 IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE 1686
Query: 724 EVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRME 783
E+ AV ++ R+L + SE + H++ T + K DL + +E
Sbjct: 1687 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQ----NTSLINQKKKMDADLSQLQTEVE 1742
Query: 784 EMEKYQESVRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAV 843
E + + ++ K A D + +E +Q SA E+ I R D A
Sbjct: 1743 EAVQECRNAEEKAKK-AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE 1801
Query: 844 NIMLE 848
I L+
Sbjct: 1802 QIALK 1806
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 40.8 bits (94), Expect = 0.006
Identities = 68/383 (17%), Positives = 147/383 (38%), Gaps = 30/383 (7%)
Query: 451 QRLQSELDVLDADIVLEEGPFILDQSASFKD-EVLAVAKTKAGKKKPVTENVPFRKK--- 506
++L E D L ++ I D+ K+ E+ + +K + NV K+
Sbjct: 193 EKLTKERDALSLELYRNT---ITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLE 249
Query: 507 --DTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTS 564
L P +Q + G++ Q S S Q V N + + W
Sbjct: 250 RAQLLLPQQQLQVEADRLGKELQ--SVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ 307
Query: 565 PPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKE 624
C LK++ + Q+E E+ E + R E ++++E
Sbjct: 308 EQEEKMCEQELKIREQEEKMWR---QEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIRE 364
Query: 625 LEELKAKEIDSMQKQ--RLDWLDAETSR---RTKELNELKAEEMYRLQQLSVSATHLADK 679
EE ++ + +++Q ++ + E R + +E E + E+M+R ++ +
Sbjct: 365 QEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIRE 424
Query: 680 VEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLD 739
EE + + + + + + E +++ K Q +E I++ +
Sbjct: 425 QEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE---------KIQRQE 475
Query: 740 DFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKI 799
+ +++ + W K+L E ++ K E M + E+M++ +E ++++ K+
Sbjct: 476 EKIQEQEEKTWR--QEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKM 533
Query: 800 AYADPRLWMQEENNDQKISAISE 822
+ RLW QEE ++ + E
Sbjct: 534 REQEVRLWQQEEKMQEQEVRLQE 556
Score = 36.2 bits (82), Expect = 0.15
Identities = 46/206 (22%), Positives = 86/206 (41%), Gaps = 20/206 (9%)
Query: 626 EELKAKEIDSMQKQRLDWLDAETSRRTKELNELK-----AEEMYRLQQLSVSATHLADKV 680
EELK K + +K RL +++E S + +LK A+ + QQL V A L ++
Sbjct: 214 EELKEKNAELQEKLRL--VESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKEL 271
Query: 681 EEAVLDRLKPLLVKAQR---VNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQ 737
+ +V +L+ + + + +N E + ++ + QE+ + E RQ
Sbjct: 272 Q-SVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQ 330
Query: 738 LDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYN 797
+ E KI E ++ K E + + E+M + +E +R++
Sbjct: 331 EEKMHEQ---------EEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDE 381
Query: 798 KIAYADPRLWMQEENNDQKISAISEK 823
KI + +W QEE ++ EK
Sbjct: 382 KIQEQEEEMWRQEEKIREQEEKRQEK 407
Score = 35.8 bits (81), Expect = 0.20
Identities = 50/201 (24%), Positives = 82/201 (40%), Gaps = 13/201 (6%)
Query: 633 IDSMQKQRLDWLDAETSRRT---KELNELKAE--EMYRLQQLSVSATHLADKVEEAVLDR 687
I+ + K+R D L E R T +EL E AE E RL + S L K + L+R
Sbjct: 192 IEKLTKER-DALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLER 250
Query: 688 LKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQ--EVAAVDFESNNIRQLDDFLEDC 745
+ LL + Q L+ S+ A+ + + + E RQ + E
Sbjct: 251 AQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQ- 309
Query: 746 ASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPR 805
E KI E ++ K E + + ++M + +E +R++ KI + +
Sbjct: 310 -EEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK 368
Query: 806 LWMQEE---NNDQKISAISEK 823
+W QEE D+KI E+
Sbjct: 369 MWRQEEKIREQDEKIQEQEEE 389
>gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens]
Length = 728
Score = 40.4 bits (93), Expect = 0.008
Identities = 61/293 (20%), Positives = 122/293 (41%), Gaps = 36/293 (12%)
Query: 493 KKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKM----NRQ 548
+K+ +T + P +TLAP + ++ +++ +SR + T+ S L +
Sbjct: 453 RKRKLTVDTP-GAPETLAPVAAP---EEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSS 508
Query: 549 PVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEA 608
KD +P P++ P + +P DA L+ E L G ++ +
Sbjct: 509 SAKDLGSPGARALPSAVPDA----------AAPADAPSG-LEAELEHLRQALEGGLDTKE 557
Query: 609 ARLAWLDAETSKRLKELEELKA---------KEIDSMQKQRLDWLDAETSRRT---KELN 656
A+ +L R+K+ E+L A +E++ ++ + + L T + KE+
Sbjct: 558 AKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIE 617
Query: 657 ELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNT 716
L+AE ++++ + S L ++E+A R+ +A R+ + A I + V
Sbjct: 618 RLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQI---EDLQVKL 674
Query: 717 AKAQPAQEVAAVDF--ESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVE 767
A+ +E D E L+ +++ +LW + GSE A +E
Sbjct: 675 QHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,195,087
Number of Sequences: 37866
Number of extensions: 1830601
Number of successful extensions: 8760
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 405
Number of HSP's that attempted gapping in prelim test: 7688
Number of HSP's gapped (non-prelim): 1345
length of query: 967
length of database: 18,247,518
effective HSP length: 112
effective length of query: 855
effective length of database: 14,006,526
effective search space: 11975579730
effective search space used: 11975579730
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.