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Search of human proteins with 154277118
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154277118 spectrin repeat containing, nuclear envelope 1
isoform 4 [Homo sapiens]
(3321 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof... 6481 0.0
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 6481 0.0
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 6468 0.0
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 1956 0.0
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 1954 0.0
gi|154277120 spectrin repeat containing, nuclear envelope 1 isof... 1890 0.0
gi|33624873 spectrin repeat containing, nuclear envelope 2 isofo... 337 2e-91
gi|33624861 spectrin repeat containing, nuclear envelope 2 isofo... 309 3e-83
gi|33188443 microfilament and actin filament cross-linker protei... 270 2e-71
gi|33188445 microfilament and actin filament cross-linker protei... 270 2e-71
gi|221316624 dystonin isoform 4 [Homo sapiens] 264 1e-69
gi|221316622 dystonin isoform 3 [Homo sapiens] 264 1e-69
gi|221316618 dystonin isoform 2 [Homo sapiens] 264 1e-69
gi|34577047 dystonin isoform 1 [Homo sapiens] 264 1e-69
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 264 1e-69
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 215 7e-55
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens] 215 7e-55
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens] 215 7e-55
gi|5032285 dystrophin Dp427l isoform [Homo sapiens] 215 7e-55
gi|5032283 dystrophin Dp427m isoform [Homo sapiens] 215 7e-55
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 170 2e-41
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 168 9e-41
gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens] 161 9e-39
gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens] 161 1e-38
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 147 1e-34
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 147 2e-34
gi|110611228 utrophin [Homo sapiens] 145 8e-34
gi|21735548 centrosomal protein 2 [Homo sapiens] 136 3e-31
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 129 4e-29
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 128 1e-28
>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
[Homo sapiens]
Length = 3321
Score = 6481 bits (16814), Expect = 0.0
Identities = 3321/3321 (100%), Positives = 3321/3321 (100%)
Query: 1 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML
Sbjct: 1 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
Query: 61 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 120
ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV
Sbjct: 61 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 120
Query: 121 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180
YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT
Sbjct: 121 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180
Query: 181 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 240
SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ
Sbjct: 181 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 240
Query: 241 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 300
EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA
Sbjct: 241 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 300
Query: 301 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 360
QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL
Sbjct: 301 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 360
Query: 361 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 420
PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI
Sbjct: 361 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 420
Query: 421 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 480
AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR
Sbjct: 421 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 480
Query: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 540
TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE
Sbjct: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 540
Query: 541 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 600
INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL
Sbjct: 541 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 600
Query: 601 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 660
EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK
Sbjct: 601 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 660
Query: 661 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720
VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE
Sbjct: 661 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720
Query: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 780
KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE
Sbjct: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 780
Query: 781 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 840
EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV
Sbjct: 781 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 840
Query: 841 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 900
LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS
Sbjct: 841 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 900
Query: 901 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 960
IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN
Sbjct: 901 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 960
Query: 961 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020
KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL
Sbjct: 961 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020
Query: 1021 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 1080
FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS
Sbjct: 1021 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 1080
Query: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII
Sbjct: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
Query: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 1200
VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR
Sbjct: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 1200
Query: 1201 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 1260
AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK
Sbjct: 1201 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 1260
Query: 1261 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 1320
SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH
Sbjct: 1261 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 1320
Query: 1321 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 1380
WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK
Sbjct: 1321 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 1380
Query: 1381 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 1440
SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI
Sbjct: 1381 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 1440
Query: 1441 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 1500
SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ
Sbjct: 1441 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 1500
Query: 1501 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 1560
ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT
Sbjct: 1501 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 1560
Query: 1561 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620
WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV
Sbjct: 1561 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620
Query: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680
SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF
Sbjct: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680
Query: 1681 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 1740
RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV
Sbjct: 1681 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 1740
Query: 1741 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 1800
NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD
Sbjct: 1741 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 1800
Query: 1801 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 1860
DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL
Sbjct: 1801 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 1860
Query: 1861 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 1920
EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL
Sbjct: 1861 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 1920
Query: 1921 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 1980
KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL
Sbjct: 1921 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 1980
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII
Sbjct: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
Query: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR
Sbjct: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
Query: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD
Sbjct: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
Query: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 2220
SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL
Sbjct: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 2220
Query: 2221 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 2280
SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL
Sbjct: 2221 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 2280
Query: 2281 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 2340
LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE
Sbjct: 2281 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 2340
Query: 2341 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 2400
KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR
Sbjct: 2341 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 2400
Query: 2401 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 2460
VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI
Sbjct: 2401 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 2460
Query: 2461 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 2520
EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE
Sbjct: 2461 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 2520
Query: 2521 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL
Sbjct: 2521 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
Query: 2581 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 2640
ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA
Sbjct: 2581 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 2640
Query: 2641 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK
Sbjct: 2641 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
Query: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 2760
SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS
Sbjct: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 2760
Query: 2761 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 2820
DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE
Sbjct: 2761 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 2820
Query: 2821 SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII 2880
SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII
Sbjct: 2821 SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII 2880
Query: 2881 RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 2940
RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG
Sbjct: 2881 RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 2940
Query: 2941 VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ 3000
VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ
Sbjct: 2941 VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ 3000
Query: 3001 TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 3060
TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS
Sbjct: 3001 TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 3060
Query: 3061 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 3120
LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM
Sbjct: 3061 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 3120
Query: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 3180
QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL
Sbjct: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 3180
Query: 3181 EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH 3240
EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH
Sbjct: 3181 EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH 3240
Query: 3241 SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL 3300
SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL
Sbjct: 3241 SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL 3300
Query: 3301 SNNFARSFHPMLRYTNGPPPL 3321
SNNFARSFHPMLRYTNGPPPL
Sbjct: 3301 SNNFARSFHPMLRYTNGPPPL 3321
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 6481 bits (16814), Expect = 0.0
Identities = 3321/3321 (100%), Positives = 3321/3321 (100%)
Query: 1 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML
Sbjct: 5477 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 5536
Query: 61 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 120
ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV
Sbjct: 5537 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 5596
Query: 121 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180
YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT
Sbjct: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
Query: 181 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 240
SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ
Sbjct: 5657 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 5716
Query: 241 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 300
EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA
Sbjct: 5717 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 5776
Query: 301 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 360
QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL
Sbjct: 5777 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 5836
Query: 361 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 420
PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI
Sbjct: 5837 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 5896
Query: 421 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 480
AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR
Sbjct: 5897 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 5956
Query: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 540
TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE
Sbjct: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 6016
Query: 541 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 600
INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL
Sbjct: 6017 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 6076
Query: 601 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 660
EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK
Sbjct: 6077 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 6136
Query: 661 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720
VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE
Sbjct: 6137 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 6196
Query: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 780
KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE
Sbjct: 6197 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 6256
Query: 781 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 840
EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV
Sbjct: 6257 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 6316
Query: 841 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 900
LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS
Sbjct: 6317 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 6376
Query: 901 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 960
IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN
Sbjct: 6377 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 6436
Query: 961 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020
KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL
Sbjct: 6437 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 6496
Query: 1021 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 1080
FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS
Sbjct: 6497 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 6556
Query: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII
Sbjct: 6557 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6616
Query: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 1200
VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR
Sbjct: 6617 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 6676
Query: 1201 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 1260
AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK
Sbjct: 6677 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6736
Query: 1261 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 1320
SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH
Sbjct: 6737 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 6796
Query: 1321 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 1380
WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK
Sbjct: 6797 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6856
Query: 1381 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 1440
SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI
Sbjct: 6857 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 6916
Query: 1441 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 1500
SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ
Sbjct: 6917 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 6976
Query: 1501 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 1560
ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT
Sbjct: 6977 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 7036
Query: 1561 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620
WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV
Sbjct: 7037 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 7096
Query: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680
SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF
Sbjct: 7097 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 7156
Query: 1681 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 1740
RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV
Sbjct: 7157 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 7216
Query: 1741 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 1800
NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD
Sbjct: 7217 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 7276
Query: 1801 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 1860
DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL
Sbjct: 7277 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 7336
Query: 1861 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 1920
EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL
Sbjct: 7337 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 7396
Query: 1921 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 1980
KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL
Sbjct: 7397 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 7456
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII
Sbjct: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
Query: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR
Sbjct: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
Query: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD
Sbjct: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
Query: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 2220
SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL
Sbjct: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 7696
Query: 2221 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 2280
SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL
Sbjct: 7697 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 7756
Query: 2281 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 2340
LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE
Sbjct: 7757 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 7816
Query: 2341 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 2400
KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR
Sbjct: 7817 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 7876
Query: 2401 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 2460
VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI
Sbjct: 7877 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 7936
Query: 2461 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 2520
EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE
Sbjct: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
Query: 2521 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL
Sbjct: 7997 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 8056
Query: 2581 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 2640
ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA
Sbjct: 8057 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 8116
Query: 2641 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK
Sbjct: 8117 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 8176
Query: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 2760
SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS
Sbjct: 8177 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 8236
Query: 2761 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 2820
DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE
Sbjct: 8237 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 8296
Query: 2821 SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII 2880
SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII
Sbjct: 8297 SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII 8356
Query: 2881 RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 2940
RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG
Sbjct: 8357 RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 8416
Query: 2941 VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ 3000
VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ
Sbjct: 8417 VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ 8476
Query: 3001 TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 3060
TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS
Sbjct: 8477 TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 8536
Query: 3061 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 3120
LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM
Sbjct: 8537 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8596
Query: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 3180
QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL
Sbjct: 8597 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 8656
Query: 3181 EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH 3240
EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH
Sbjct: 8657 EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH 8716
Query: 3241 SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL 3300
SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL
Sbjct: 8717 SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL 8776
Query: 3301 SNNFARSFHPMLRYTNGPPPL 3321
SNNFARSFHPMLRYTNGPPPL
Sbjct: 8777 SNNFARSFHPMLRYTNGPPPL 8797
Score = 221 bits (562), Expect = 1e-56
Identities = 613/3378 (18%), Positives = 1294/3378 (38%), Gaps = 366/3378 (10%)
Query: 7 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 66
++ + + G+ L ++ LTE+ +EN K + L + L +L
Sbjct: 1170 IRNGVTKRGETLSWLKSRLKVLTEV------SSENEAQKQGDELAKLSSSFKALVTLLSE 1223
Query: 67 IEK-----AKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
+EK + + I NS +L + SKE+ + E + + +
Sbjct: 1224 VEKMLSNFGDCVQYKEIVKNSLEEL----------ISGSKEVQEQAEKILDTENLFEAQQ 1273
Query: 122 CTEKMSQQVAELGRETEELRQMIKIRLQN---LQDAA-KDMKKFEAELKKLQAALEQA-- 175
Q+ + + +++Q I Q L D ++++K E+ L L+ + E+
Sbjct: 1274 LLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQER 1333
Query: 176 --QATLTSPE--------VGRLSLKEQLSHRQHL-LSEMESLKPK--------------- 209
Q TL E V R + SH + L S +ESL +
Sbjct: 1334 RIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIA 1393
Query: 210 VQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 269
VQA L + A IP L A ++E+ +L+ T + M+ +++ +
Sbjct: 1394 VQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGS 1453
Query: 270 EMKHLQQLIEGAHREIEDKPVATS----NIQELQAQISRHEELAQKIKGYQEQIASLNSK 325
+ L I +E+ ++S I +++ I E I G +E+ S
Sbjct: 1454 NFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSF--- 1510
Query: 326 CKMLTMKAKHATMLLTVTEV----EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLL 381
+ A + +T++ E L E + L+G +L H S +
Sbjct: 1511 -AQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTIL----GHLSQQQKFEENLRKIQ 1565
Query: 382 SPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPS 441
V+E + +I S T + + + QAL + +A S
Sbjct: 1566 QSVSEFEDKLAVPIKICSS--------ATETYKVLQEHMDLCQALES----LSSAITAFS 1613
Query: 442 TSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIST 501
SA + A A LQ+ +E + E+Q L L Q+ + L S T
Sbjct: 1614 ASARKVVNRDSCVQEAAA----LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLT 1669
Query: 502 KMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADP 561
+E E K S SPE ++ + ++ L +L +L E+VS
Sbjct: 1670 WLERGEAKAS-------SPEMDISADRVKVEGEL-------QLIQALQNEVVS------- 1708
Query: 562 AEQLALQSTLTVLAERMSTIRMKASGKRQLLE-EKLNDQLEE-----QRQEQALQRYRCE 615
Q + S L L E + ++ K K L E+L+++ + ++ LQ E
Sbjct: 1709 --QASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAE 1766
Query: 616 ADELDSWLLSTKATLDTALSPPKEP-----MDMEAQLMDCQNMLVEIEQKVVALSELSVH 670
+ D LLS + LS + MD + L ++ E+E K L L H
Sbjct: 1767 HQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGH 1826
Query: 671 NENL----------LLEGKAHTK----DEAEQLAGKLRRLKGSLLE-------LQRALHD 709
L LL+GKA +EA Q+ + + L E L L
Sbjct: 1827 LAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQ 1886
Query: 710 KQLNMQGT-AQEKEESDV---DLT-ATQSPGVQEWLAQA------------RTTWTQQRQ 752
+ ++ T + K ESD+ DL A Q+ E A + + ++QR
Sbjct: 1887 LRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT 1946
Query: 753 SSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK 812
S +L E+ ++LL + S + + + A + +K ++L +E E+
Sbjct: 1947 SCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQD-----QKEELLKSIEDIE-ER 2000
Query: 813 SSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK 872
+ E ++L Q +L + E E + ++ + ++
Sbjct: 2001 TDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREI 2060
Query: 873 SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL 932
+ + D + E Q G I L ++ + SA S L++ + T +
Sbjct: 2061 NRLEVTWDDTKRLIHENQGQCCGL----IDLMREYQNLKSAVSKVLENASSVIVTRTTIK 2116
Query: 933 PEETETCLFNQEILAKDI-----KEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLG 987
+E F++ AK+ K++ K K+L S+ + + +++ + +
Sbjct: 2117 DQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVD 2176
Query: 988 RLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI 1047
+ LD V+++ + +RL+ L+ +D+ S D ++ +N +AE I
Sbjct: 2177 KW--LD--VSEKLEENMDRLRVSLSIWDDV----LSTRDE----IEGWSNNCVPQMAENI 2224
Query: 1048 EAIQ---QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSG 1104
+ +AE+ LKEF++ + R ++L + ++EL+K + +L I
Sbjct: 2225 SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQK 2284
Query: 1105 LNQNLTLKSQYERALQDLADLLETGQEKMAGD---------QKIIVSSKEEIQQLLDKHK 1155
L + + L+D T EK D + ++ ++ E + L K K
Sbjct: 2285 LEHAKEITEVAKGTLKDFT-AQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVK 2343
Query: 1156 EY---FQGLESHMILTE----TLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 1208
+ Q +S++ T+ +L RK S ++ + T L+ + AV + K L
Sbjct: 2344 DIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASL 2403
Query: 1209 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL------YQHLKSS 1262
+ LE H E QE E + + +E+ DR D L Q++ S
Sbjct: 2404 QESLE--KHFSESMQEFQ------EWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDS 2455
Query: 1263 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 1319
+++ Q KL V +G+ L +S S ++ Q+ + E + + + K+ L+
Sbjct: 2456 VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCAS 2515
Query: 1320 HWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEV-DAQSS 1378
++ + L W+ ++R F T+ Q + ++ ++ F E+ A+ S
Sbjct: 2516 ELGSFEDQHRKLNLWIHEMEER--FNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2573
Query: 1379 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 1438
L LS QLL + S++ + +LL +EKL Q+ L
Sbjct: 2574 LDK--LSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLR---MTKEKLRSCQV-ALQEHE 2627
Query: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYK-AIHEYLQKYKGFKIDINCKQLTVDF-VNQ 1496
A+ E + + IQ ++++G K + + L + + + ++ ++ + +
Sbjct: 2628 ALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK 2687
Query: 1497 SVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQ 1556
+ S + E +R +T QL + + W + LE ++ W++Y
Sbjct: 2688 GEQALRSSNKEGQRVIQT----QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKN 2743
Query: 1557 CLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNK 1616
L+ W E+ ++++ +H + Q ++ L+ ++ E + + LI
Sbjct: 2744 QLEQWMESVDQKI--EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHR----LIAKS 2797
Query: 1617 KEDVSSIVMSTLRELGQTW--ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSY---LM 1671
+E + ++ Q + ++ K ++ V + H + D ++ + L
Sbjct: 2798 RELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLH 2857
Query: 1672 EARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 1731
A+ L R+ ++G A Q ++ ++ L D E L + S+ ++ + E
Sbjct: 2858 SAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCE 2917
Query: 1732 TLTNTLKEVNMRWNNLLEEIAEQLQSSKALL-QLWQRYKDYSKQCASTVQQQEDRTNELL 1790
+ ++ + W + + + + L+ Q+ +++S Q A ++Q ++ + LL
Sbjct: 2918 LMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQ-LEQALEQFSALL 2976
Query: 1791 KAATNK------DIADDEVATWIQDCNDLLKGLGTVKDSLFFLH-ELGEQLKQQVDASAA 1843
K + D+E+ ++L L + L +L E + D S
Sbjct: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
Query: 1844 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQG-- 1901
S S + LC C+ + + + F K+ + W+V A+
Sbjct: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQ-----QRFRKAFRDFQQWLVNAKITTAKCF 3091
Query: 1902 QDPSHSSDLST----IQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQN- 1956
P + S++ST IQE + E + K + M + L+ L L ++ K +Q
Sbjct: 3092 DIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTL-----LTKEKAKGIQAK 3146
Query: 1957 ---LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQH 2013
W S ++ S L++ +Q + F E ++L +TE K+ E S
Sbjct: 3147 VTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTE-KMVHESSNRLYD 3205
Query: 2014 LLEQQRAHELFQA---EMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQG 2070
L ++R + Q+ E+ + L+ + Q+L E GQ + F +++ LS+Q+
Sbjct: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE-GQAASKS-FRHRVSQLSSQYLA 3263
Query: 2071 VIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDE 2130
+ +++ +D + + ++ ++L+ W+ + ++ L S P L
Sbjct: 3264 LSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHM----LDSYCHPTSDKSVLDSR 3319
Query: 2131 VQFKEKVFLRQQGSYI---LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEE 2187
E + +Q I + V G+ +L + +Q +L +++ W S
Sbjct: 3320 TLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3379
Query: 2188 QKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQM--RCKELENAV 2245
K +L L W + G+ + + + L++S H E M + K L V
Sbjct: 3380 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEV 3439
Query: 2246 GSWTDDLTQLSLLKDTLSA-YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN 2304
S++ L + + ++ Y++ ++ L ER +Q + +E ++ + + RL+
Sbjct: 3440 LSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKE-----AVTKSEKLVRLH 3494
Query: 2305 EWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMG 2364
+ + K WL Q + K+ Q ++E ++ + QE ++ + G
Sbjct: 3495 Q--EYQRDLKAFEVWLGQEQEKLDQYS------VLEGDAHTHETTLRDLQELQVHCAE-G 3545
Query: 2365 ERLAKASHESKASEIEYKLGKVNDR--------WQHLLDLIAARVKKLKETLVAVQQLDK 2416
+ L + ++ I + + DR WQ ++ + + ++ +++
Sbjct: 3546 QALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3605
Query: 2417 NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
+ WL E +++ P N + +L++ ++ ++ + V V +
Sbjct: 3606 KFQQVDEWLKTAEEKVS-PRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQE 3664
Query: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
+L + + C + Q L R++ + +E+ +EE + ++ S +
Sbjct: 3665 ILDESHVNSRMG-CQATQ-----LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYS 3718
Query: 2537 DWLKSSERTAAFPSSS--GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAREN 2594
DW S+ + ++ V + ++LK E + + + + L+ ++ R +
Sbjct: 3719 DWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL 3778
Query: 2595 RTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD-- 2652
A L++ +H+ ++ L V L+ + +EF ++ W+ E
Sbjct: 3779 EEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEI 3838
Query: 2653 LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 2712
L + + +A++ + K+ QQ + + ++ + +GE L+E + + ++++
Sbjct: 3839 LHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT---LKDK 3895
Query: 2713 LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 2772
+D+L+ Q++ + + H + + D E D EL++ W + + L
Sbjct: 3896 IDQLQSDYQDLCS-IGKEHVFSLEAKVKDHE----DYNSELQEVEK-----WLLQMSGRL 3945
Query: 2773 LSPQPSSNLSL-SLAQPLRSERSGRDTPASVDSI--PLEWDHDYDLSRDLESAMSRALPS 2829
++P SL ++ Q L ++ + A + L+ D + + + ++ +
Sbjct: 3946 VAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQN 4005
Query: 2830 EDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 2889
Q KD Y + +LE ++ Q + D+ Q Q + ++ P+
Sbjct: 4006 VHAHLQGTKDSYSAICSTAQRMYQSLEHEL-QKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
Query: 2890 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT-AGVIDRWELL 2948
S E + + L+ + + + L +L + +T A I + E
Sbjct: 4065 PPLSR-------AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE-- 4115
Query: 2949 QAQALSKELRMKQNL-QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 3007
Q + ++L QNL Q W++ + +W +L D +++L+ ++R ++ + +
Sbjct: 4116 --QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVS 4173
Query: 3008 KLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRG 3067
++K+ K + ++A S+N + + KE ++ +N +W +C
Sbjct: 4174 QVKDFVKKLQSKQA---SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCL 4230
Query: 3068 LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL 3127
++ L + + +H+ + + + LE + + + DAE H + L ++ L
Sbjct: 4231 QREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNL----ARSDAESTAVHLEALKKLALALQ 4286
Query: 3128 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL----KLLLKEVSRHIKELEKL 3183
E + + L+D +++ + D KE+ + R L+ +++ + LE+L
Sbjct: 4287 ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEEL 4346
Query: 3184 LDVSSSQQDLSSWSSADE 3201
V S Q+L W+ +
Sbjct: 4347 NVVQSRFQELMEWAEEQQ 4364
Score = 197 bits (500), Expect = 2e-49
Identities = 625/3331 (18%), Positives = 1275/3331 (38%), Gaps = 467/3331 (14%)
Query: 31 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI-EKAKVLAHGTIAWNSASQLREQ 89
L + T + + RL NQ L + E L W+ +KAK +A +A+
Sbjct: 2006 LKEPTRQALQQRLRVFNQLEDELNSH----EHELCWLKDKAKQIAQKDVAF--------- 2052
Query: 90 YILHQTLLEESKEIDSELEAM------TEKLQYLTSVYCTEKMSQQVAELGRETEELRQM 143
+ E+D E+ + T++L + C + +L RE + L+
Sbjct: 2053 ----------APEVDREINRLEVTWDDTKRLIHENQGQCCG-----LIDLMREYQNLKSA 2097
Query: 144 IKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM 203
+ L+N + + + L+ A + + + L S +HLLSE+
Sbjct: 2098 VSKVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL 2156
Query: 204 ESLKP------KVQAVQLCQSALRIPEDVV-------ASLPLCHAALRLQEEASRLQHTA 250
+ + K L + E + SL + L ++E +
Sbjct: 2157 KKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNC 2216
Query: 251 IQQC--------NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ------ 296
+ Q N ++A + +++E E+K+ +E H ++ D T N++
Sbjct: 2217 VPQMAENISNLDNHLRAEEL-LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQ 2275
Query: 297 ----ELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT-------MKAKHATMLLTVTEV 345
+L ++ +E+ + KG + + +++ + K + + M E
Sbjct: 2276 FIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNET 2335
Query: 346 EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRS 405
+ +D+ EL S S C S E G T +
Sbjct: 2336 CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQL 2395
Query: 406 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQ 465
S T AS+ + + + + S + Q + +A + G AKL DLQ
Sbjct: 2396 CS---KTQASLQESLEKHFSESMQEFQ--EWFLGAKAAAKESSDRTGDSKVLEAKLHDLQ 2450
Query: 466 RSWETLK------NVISEKQRTLYEALERQQKYQDSLQSISTKM-EAIELKLSESPEPGR 518
+++ + ++++ +TLY L +Q S+Q TK E + L + + +
Sbjct: 2451 NILDSVSDGQSKLDAVTQEGQTLYAHLSKQ--IVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
Query: 519 SPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 578
+ + +E + D+ L I+E++ E + ES + P ++ + L E +
Sbjct: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
Query: 579 STIRM--KASGKRQLLEEKLNDQLEEQRQ-EQALQRYRCEADELDSWLLSTKATLDTALS 635
+ K S + QLL E+ + +E R Q L ++ + L TK L +
Sbjct: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQ-------NLLRMTKEKLRSCQV 2621
Query: 636 PPKEPMDMEAQLMDCQNMLVEIEQKVVAL-----------SELSVHNENLLLEGKAHTKD 684
+E +E L + I+ ++ LS + LL++G+ K
Sbjct: 2622 ALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKL 2681
Query: 685 EAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQA- 743
G+ + L+ S E QR + + ++ + S V +T + +W
Sbjct: 2682 NMAIGKGE-QALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVE 2740
Query: 744 RTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQH-----SAAETSGDAGEK 798
R +Q S+ Q ++E L Q L + + +L+ H S AE A +
Sbjct: 2741 RKNQLEQWMESVDQ--KIEHPLQPQPGL------KEKFVLLDHLQSILSEAEDHTRALHR 2792
Query: 799 PDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQK-LLQNVLEQEQEQVLYSRPNRLL 857
S+EL + E S +D + + ++ + T K ++ V E ++ ++Y
Sbjct: 2793 LIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMY------- 2845
Query: 858 SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSG--GAKRQSIHLEQKLYDGVS 912
AV D L+ A EE+ S SG A ++ + ++L D
Sbjct: 2846 --------------LDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSRE 2891
Query: 913 ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 972
++ L VE +L PE Q A + M EM + + Q
Sbjct: 2892 IGASRLSRVE-------SLAPE------VKQNTTASGCELMHTEMQALRADWKQW----- 2933
Query: 973 DNRDVIEDTLGC---LLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKY 1029
D + T C L+ +++L + + + Q+++ L+Q F LK L
Sbjct: 2934 --EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQ---FSALLKTWAQQLT---- 2984
Query: 1030 IILQKLANVFEQPV------AEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 1083
L + N E+ V E ++A+Q+AE ++ + + EL R L +
Sbjct: 2985 --LLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
Query: 1084 LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSS 1143
L K + + + + + N+ L+ ++ +A +D L + A I +
Sbjct: 3043 LIK-----EYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFD-IPQN 3096
Query: 1144 KEEIQQLLDKHKEYFQGLESHMILTETLFRK--IISFAVQKETQFHTEL-MAQASAVLKR 1200
E+ L K +E+ E+ + K ++S + KE + + A K
Sbjct: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKN 3156
Query: 1201 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV-GLVEENEDRLID---RITLY 1256
H + E LE +L ++ E ++ + +V E+ +RL D +
Sbjct: 3157 FHSNLHQKESALE---NLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQ 3213
Query: 1257 QHLKSSLNE---YQPKLYQVLDDGKRLLISISCS-DLESQLNQLGECWLSNTNKMSKELH 1312
Q L+S L E Y+P+L ++ + ++L + S +++QL +L+ +N +++
Sbjct: 3214 QKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVS 3273
Query: 1313 RLETILKHWTRYQSESADLIHWLQSAKDRLEFW----TQQSVTVPQELEMVRDHLNAFLE 1368
RL+ I+ ++ +L W+ A L+ + + +SV + L+ L A L
Sbjct: 3274 RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLK-----LEALLS 3328
Query: 1369 FSKEVDAQSSLKSSVLSTGNQLLRLKKVD-TATLRSELSRIDSQWTDLLTNIPAVQEKLH 1427
+E + Q + +++ G +L+ + T++ +L + W LL+ + +L
Sbjct: 3329 VKQEKEIQMKM---IVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3385
Query: 1428 QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 1487
+ + + W+ ME + + E H L+ D
Sbjct: 3386 GALSKWTSYQDGVRQFSGWMDSMEANLNESERQ----------HAELR-------DKTTM 3428
Query: 1488 QLTVDFVNQSVLQISS--QDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKIQLLE 1542
+N+ VL SS + +E K + T+ +L + + ++ +Q E + E
Sbjct: 3429 LGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSE 3488
Query: 1543 GLLESWSEYENNVQCLKTWFETQEKRLKQQHRI-GDQASVQNALKDCQDLEDLIKAKEKE 1601
L+ EY+ +++ + W ++++L Q + GD + + L+D Q+L+ + E
Sbjct: 3489 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ--VHCAE-- 3544
Query: 1602 VEKIEQNGLALIQNKKEDV--SSIVMS---TLRELGQTWANLDHMVGQLKILLKSVLDQW 1656
Q L + + +EDV S I + L L Q W H + + + +V+++
Sbjct: 3545 ----GQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL 3600
Query: 1657 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 1716
+ F +++ +L A +S + ++Q+ ++ +++ +++ G+
Sbjct: 3601 RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA 3660
Query: 1717 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 1776
++L E H V + ++ R+ LL ++ EQ++ + +Q + S+
Sbjct: 3661 RAQEILDESH--VNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEE----SESSL 3714
Query: 1777 STVQQQEDRTNELLK-AATNKDIADD-EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQL 1834
S+ T++ K AT D D + ++ LLK + L E GE+
Sbjct: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
Query: 1835 KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVE 1894
+ ++ A ++ + + L L + K+ +L+ G+ + F+ +AL WI E
Sbjct: 3775 VKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAE 3834
Query: 1895 AEEILQGQDPSHSSDLSTIQERME--ELKGQMLKFSSM-------APDLDRLNELGYRL- 1944
+EIL + + +ME E K Q+ K+ S+ P + + E G L
Sbjct: 3835 YQEILHVPE----------EPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALL 3884
Query: 1945 -PLNDKEIK-RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQK 2002
+ D +K ++ L + + S E L++ + H+ + + + ++L+Q +
Sbjct: 3885 ELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
Query: 2003 LAVE---ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL 2059
L + + + + +Q H+ E+ + L+++ + G L+ GQ D + L
Sbjct: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI--GQCADHLQAKL 4002
Query: 2060 K------LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSG 2113
K L + + + AQ+ ++ ++++ ++ ++ + WL V P
Sbjct: 4003 KQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ--PDLE 4060
Query: 2114 LGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAE 2173
P PL +A + F+ L++Q L LL S + A+++ +
Sbjct: 4061 PSPQP-PLSRAEAIKQVKHFRA---LQEQARTYL------DLLCSMCDLSNASVKTTAKD 4110
Query: 2174 IQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHA 2233
IQ+ ++ +L + + L + W E+++ K +L L D ++L
Sbjct: 4111 IQQTEQTIEQKLVQAQN----LTQGW-----------EEIKHLKSELWIYLQDADQQLQN 4155
Query: 2234 EQMRCKELE-----NAVGSWTDDLTQLSLLKDTLSAYI------SADDISILNERVELLQ 2282
+ R ELE N V D + +L + +++ I + + S ++ + L
Sbjct: 4156 MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4215
Query: 2283 RQWEELCHQ---LSLRRQQIGER-------LNEWAVFSEKNKELCEWLTQMESKVSQNGD 2332
QW +LC Q L L+R++ +R +N VF E K EW S
Sbjct: 4216 DQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLE--KFTTEWDNLARSDAESTAV 4273
Query: 2333 ILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQH 2392
L E ++KL QE ++ K Q Q+M E L E ++ + + RW
Sbjct: 4274 HL--EALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKEL----VKEQTSHLEQRWFQ 4327
Query: 2393 LLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNE 2452
L DLI +++ L + + L W + +A+ + S + Q L +
Sbjct: 4328 LEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL-KQSPPPDMAQNLLMD 4386
Query: 2453 QQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA---ECDSIQQATRNLDRRWRNICA 2509
+ ++E L + L+ D D D E IQ+A + +
Sbjct: 4387 HLAICSELEAKQM-------LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSD 4439
Query: 2510 MSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAF 2569
+ +RR + + +FL + ++ ER F ++ +++K ++
Sbjct: 4440 LVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSA 4499
Query: 2570 QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKH 2629
Q + ++ + Q R L +E + + E +D++ ++ + L+ L+
Sbjct: 4500 QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEK 4559
Query: 2630 FIGQREEFETARDSILVWLTEMDL----QLTNIEHFSECDVQ-AKIKQLKAFQQEISLNH 2684
+ R+ F+ D WL + D+ ++ + SE Q AK + + E
Sbjct: 4560 NLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY---E 4616
Query: 2685 NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH 2744
N + + G+ ++ +D + + E+L+ L R + + D +
Sbjct: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK------------DKFY 4664
Query: 2745 DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 2804
+ + L ++ A+L +L + +LS AQ LR + D A ++
Sbjct: 4665 KVQEAILARKEYASLIEL--------------TTQSLSELEAQFLRMSKVPTDL-AVEEA 4709
Query: 2805 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGK 2864
+ L+ D R + ++ + DE Q + F G L + +L +
Sbjct: 4710 LSLQ-----DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKR 4764
Query: 2865 ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEE--- 2921
Q +Q +++ T ++Y+ + K+ + + SVK + K+ EE
Sbjct: 4765 -------QTEQRVSLLEDTT-------SAYQEHEKMCQQLERQLKSVKEEQSKVNEETLP 4810
Query: 2922 -EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL------RMKQNLQKWQ------- 2967
EE L + +L + Q +G++ + + + L+ L + + +Q WQ
Sbjct: 4811 AEEKLKMYHSL-AGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLT 4869
Query: 2968 ------------------QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 3009
F ++++ WL + EL L+L ++Q I+ +I+K+
Sbjct: 4870 SAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL--NLQDIQEEIRKI 4927
Query: 3010 KELQKAVDHRKAIILSINLCSPE-FTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL 3068
+ Q+ V I+ +++ E FT+A S DL+ L++++ + L +
Sbjct: 4928 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQAT 4987
Query: 3069 LQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSN-LDAEILQDHHKQLMQIKHELL 3127
L + QCQ ++++ LE+ E++ + N LD E +++ K M+
Sbjct: 4988 LTEIYSQCQRYYQVFQAANDWLED----AQELLQLAGNGLDVESAEENLKSHMEFFSTED 5043
Query: 3128 ESQLRVASLQDMSCQL--LVNAEGTDCLEAK 3156
+ + L + L L+ G + LE K
Sbjct: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLEQK 5074
Score = 171 bits (434), Expect = 8e-42
Identities = 597/3333 (17%), Positives = 1269/3333 (38%), Gaps = 437/3333 (13%)
Query: 5 AAVQKFLEQNGQLGK----PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
A+V +E+ +L K P K+I L + RQ+ N + + +Y++ +
Sbjct: 4187 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4246
Query: 61 ELILKWIEKAKVLAHGTIAW-NSASQLREQYILH-------QTLLEESKEIDSELEAMTE 112
++ ++EK T W N A E +H L+E K +L+ +
Sbjct: 4247 NVVEVFLEKF------TTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ 4300
Query: 113 KLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAAL 172
K+ ++ E + +Q + L + +L +IK ++Q +++ ++ ++L
Sbjct: 4301 KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWA 4360
Query: 173 EQAQATLTS-------PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPED 225
E+ Q + P++ + L + L+ L ++ LK ++ + L + E
Sbjct: 4361 EEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNER 4420
Query: 226 VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI 285
V L A Q + L Q+ + A+ + Q+ + I+ R+I
Sbjct: 4421 QVIQKALSDA----QSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI 4476
Query: 286 EDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 345
+ ++ Q+ + +K YQ ++ L A+ ++ VTE
Sbjct: 4477 MFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL---------WAQGRELMKEVTEQ 4527
Query: 346 EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT-----EESGEEGTNSEISSP 400
E ++ G+L S + SV+ + R L + +E ++ + +
Sbjct: 4528 E-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD 4582
Query: 401 PACRSPSPVANTDASVNQDIAYYQALSAE---------RLQTDAAKIHPSTSASQEFYEP 451
+ N + ++ +A YQ + + LQ I PS + Y
Sbjct: 4583 IVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY-- 4640
Query: 452 GLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD----SLQSISTKMEAIE 507
+ KL L R + + + +K + EA+ +++Y + QS+S ++EA
Sbjct: 4641 -----LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS-ELEAQF 4694
Query: 508 LKLSESPEPGRSPESQMAEH--QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 565
L++S+ P E+ + +A++DE+ L + ++EL E S P + L
Sbjct: 4695 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQK-KEGFRSTGQPWQPDKML 4753
Query: 566 ALQSTLTVL----AERMSTIRMKASGKR------QLLEEKLNDQLEEQRQ--------EQ 607
L + L +R+S + S + Q LE +L EEQ + E+
Sbjct: 4754 HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEE 4813
Query: 608 ALQRYRCEADEL-DSWLLSTKATLDTA-LSPPKEPMDMEAQLMDCQNMLVEIEQKVVALS 665
L+ Y A L DS ++ + T+ L+P +P+ E Q+ E++ A+
Sbjct: 4814 KLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIG 4873
Query: 666 ELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSL-----LELQRALHDKQLNMQGTAQE 720
E E+ +++ + E + LRR+K L L+L +++ QE
Sbjct: 4874 ETVTECESRMVQ-SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQE 4932
Query: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE----QKSLLRSVA 776
+ +S + + S +E +A+ + + SL + EL+ ++ E +++ L +
Sbjct: 4933 EVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIY 4992
Query: 777 SRGEEILIQHSAA--------ETSGDAGEKPDVLSQELGMEG--EKSSAEDQMRMKWESL 826
S+ + AA E AG DV S E ++ E S EDQ E L
Sbjct: 4993 SQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEEL 5052
Query: 827 HQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAF 886
H +T L++ +++ EQ + S R ++D A LL +
Sbjct: 5053 HSLVATLDPLIKPTGKEDLEQKVASLELR---------SQRMSRDSGAQVDLLQRCTAQW 5103
Query: 887 EEVSSQSGGAKRQSIHL----EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFN 942
+ A+ + I L E+KL + ++ + EE+L AL+ F+
Sbjct: 5104 HDYQK----AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNS---FH 5156
Query: 943 QEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQ 1002
++I+A ++E + +++K N S+A + ++ + R + L +V +
Sbjct: 5157 EKIVA--LEEKASQLEKTGNDASKA---------TLSRSMTTVWQRWTRLRAVAQDQEKI 5205
Query: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062
+++ + + F N +K T + D LQ A + E + L+ D
Sbjct: 5206 LEDAVDEWTGFNNKVKKA-TEMIDQ----LQDKLPGSSAEKASKAELLTL----LEYHDT 5256
Query: 1063 GIIELKRRGDKLQV-------------------EQPSMQELSKLQDMYDELMMIIGSRRS 1103
++EL+++ L + E P MQE++ +QD + + +
Sbjct: 5257 FVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5316
Query: 1104 GLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES 1163
+ Q L + E + + ++ +E + I + EE+Q LL + + Q +E
Sbjct: 5317 LVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK 5376
Query: 1164 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ 1223
+ E K + T +EL Q + V R + I E Q
Sbjct: 5377 ---MAEEQKEKYLGL----YTILPSELSLQLAEVALDLKIRDQIQDKIKEV-EQSKATSQ 5428
Query: 1224 ELSRQLEVVESSIPSV-GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
ELSRQ++ + + ++ ++ D ++ T + L L+ KL + LD + +
Sbjct: 5429 ELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLME-LDAAVQKFL 5487
Query: 1283 SIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAK 1339
+ L ++ +L E + L +L H Y ++ W++ AK
Sbjct: 5488 EQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK 5547
Query: 1340 DRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV--D 1397
L T + Q E H LE SKE+D++ + L + +K+
Sbjct: 5548 -VLAHGTIAWNSASQLREQYILH-QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ 5605
Query: 1398 TATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKD 1457
A L E + L N+ + + + + + + A+ + + ++ E
Sbjct: 5606 VAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPE----VG 5661
Query: 1458 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 1517
++K + ++ L + + K + QL QS L+I V S
Sbjct: 5662 RLSLKEQLSHR--QHLLSEMESLKPKVQAVQLC-----QSALRIPEDVVAS-----LPLC 5709
Query: 1518 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH-RIG 1576
+ + LQ ++ +++ + + +YE ++ L+ E + ++ +
Sbjct: 5710 HAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS 5769
Query: 1577 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 1636
+ +Q + ++L IK ++++ + L K + ++ + L +
Sbjct: 5770 NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE 5829
Query: 1637 NLD---------------HMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR 1681
+LD G+ LL V ++ S + +I+S A S S
Sbjct: 5830 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE-SGEEGTNSEISS--PPACRSPSPVA 5886
Query: 1682 LLTGSL--EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKE 1739
S+ + Q + + LQ D K S T+ + P + + T L +
Sbjct: 5887 NTDASVNQDIAYYQALSAERLQTDAAKIHPS-------TSASQEFYEPGLEPSATAKLGD 5939
Query: 1740 VNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIA 1799
+ W L I+E+ ++ L+ Q+Y+D + ++ ++ E + +E + + +
Sbjct: 5940 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
Query: 1800 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859
E + + L + ++ SL EL + + D + A+QS L++ +
Sbjct: 6000 MAEHQALMDEILMLQDEINELQSSL--AEELVSE-SCEADPAEQLALQSTLTVLAERMST 6056
Query: 1860 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEI---LQGQDPSHSSDLSTIQER 1916
+ ++ L+ + D + +AL+ + EA+E+ L + + LS +E
Sbjct: 6057 IRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP 6116
Query: 1917 MEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 1976
M +++ Q++ +M ++++ L ++++ + + H + Q + +L+
Sbjct: 6117 M-DMEAQLMDCQNMLVEIEQKVVALSELSVHNENL--LLEGKAHTKDEAEQLAGKLRRLK 6173
Query: 1977 SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI----SGNYQHLLEQQRA------------ 2020
LL+ Q L + M+ Q +++ V++ S Q L Q R
Sbjct: 6174 GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ 6233
Query: 2021 HELFQAEMFSRQQILHSIIIDGQR-LLEQGQVDDRDEFNLKLTLLSNQ------------ 2067
+ + E+ ++ +L S+ G+ L++ + + K +LS +
Sbjct: 6234 QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED 6293
Query: 2068 -----WQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ 2122
W+ + + ++ ++ + + Q Q + R +S +P+ G VP +
Sbjct: 6294 QMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRL----LSGVPLY-KGDVPTQDK 6348
Query: 2123 QART-LFDEV-QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKS 2180
A T L D + Q E+V + G+ ++ ++L +A L +++E+
Sbjct: 6349 SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY-----DGVSATSTWLDDVEERLFV 6403
Query: 2181 ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE 2240
A+ L E+ + F + E K I + E++ K SQ+ P++ +
Sbjct: 6404 ATALLPEETETCLF---NQEILAKDIKEMSEEMDKNKNLFSQAFPENGD----------- 6449
Query: 2241 LENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 2300
+++DTL + R+ LL + CHQ+ R QQI
Sbjct: 6450 -------------NRDVIEDTLGCLLG---------RLSLLDSVVNQRCHQMKERLQQIL 6487
Query: 2301 ERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQL 2360
N+ L + + ++ N I+++++ ++ E+I Q+ + L
Sbjct: 6488 NFQND--------------LKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 6533
Query: 2361 QQMGERLAKASHESKASEIE----YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK 2416
++ + + ++E +L K+ D + L+ +I +R L + L Q ++
Sbjct: 6534 KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER 6593
Query: 2417 NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
+ L L + ++A + EEIQ+ L++ +E + +E H + L E
Sbjct: 6594 ALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH-------MILTET 6646
Query: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
L + A E Q L + + + +R +++E W LD E
Sbjct: 6647 LFRKIISFAVQKE----TQFHTELMAQASAVLKRAHKRGVELEYILETW-SHLD-----E 6696
Query: 2537 DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENR- 2595
D + S + SS + V + E + + H + E K Y+ L R
Sbjct: 6697 DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL 6756
Query: 2596 --TDSACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREE-------FETARD 2642
+ S L+ +++ + W + +++ L R LKH+ + E ++A+D
Sbjct: 6757 LISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKD 6816
Query: 2643 SILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 2702
+ W + +E V+ + F +E+ + +++ G QL+ + +
Sbjct: 6817 RLEFWTQQSVTVPQELEM-----VRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL-RLK 6870
Query: 2703 PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSD- 2761
+D A + EL + ++ + +KL +L + +L A+S+
Sbjct: 6871 KVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMD-----------KLPSRHAISEV 6919
Query: 2762 LHWHDRSADSLLSPQPS--SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL---S 2816
+ W + + + + +++ + G + + +++ + L S
Sbjct: 6920 MSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISS 6979
Query: 2817 RDLESAMSRALPSEDEEGQDDKDF-YLRGAV--------GLSGDHSALESQIRQLGKALD 2867
+D+ES S ++ G +K + L+G V GL S E+ ++ L +
Sbjct: 6980 QDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFE 7039
Query: 2868 DSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPG 2927
+++Q I L +C D +K E ++++ E++ G
Sbjct: 7040 TQEKRLKQQHRI------------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--G 7085
Query: 2928 FVNLHSTETQTAGVI--------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 2979
+ + + + ++ W L ++ +K L +W + I ++
Sbjct: 7086 LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSY 7145
Query: 2980 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADS 3038
L + L + + L+ ++ +++Q+ L+ LQ ++ ++ + ++ + +
Sbjct: 7146 LMEARYSLSRFRL--LTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 7203
Query: 3039 KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDR 3095
+ L + L ++N RW+ +LLEE LQ AL+Q Q + + S ++ +
Sbjct: 7204 PVTETLTNTLKEVNMRWN---NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
Query: 3096 RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLE 3128
R NE++ +N D I D +Q ++LL+
Sbjct: 7261 RTNELLKAATNKD--IADDEVATWIQDCNDLLK 7291
Score = 155 bits (391), Expect = 8e-37
Identities = 476/2589 (18%), Positives = 980/2589 (37%), Gaps = 324/2589 (12%)
Query: 26 GKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ 85
G++ +L +Q + Q L Q + LE N E++ W + ++L A
Sbjct: 2960 GQVAQL-EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3018
Query: 86 LREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY----------CTEK---MSQQVAE 132
L+ Q L E +L + K+ L Y C K + Q+ +
Sbjct: 3019 LKSQ-------LNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRK 3071
Query: 133 LGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQ 192
R+ ++ KI D +++ + L+K+Q L ++ E G+ L
Sbjct: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES-------ENGQHKLNMM 3124
Query: 193 LSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQ 252
LS + LLS + + K K + +Q +A + ED H+ L +E A L++ IQ
Sbjct: 3125 LS-KGELLSTLLT-KEKAKGIQAKVTAAK--ED----WKNFHSNLHQKESA--LENLKIQ 3174
Query: 253 QCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA----------QI 302
M+ V E + + ++++ + + D P Q+LQ+ Q+
Sbjct: 3175 ----MKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQL 3230
Query: 303 SRHEELAQKI-------KGYQEQIASLNSKCKMLTMKAKHATMLLT--VTEVEGLAEGTE 353
+R +E AQ++ K ++ +++ L+S+ L+ K L V E + G +
Sbjct: 3231 NRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIK 3290
Query: 354 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTD 413
+L + T + H M CH P +++S + ++ +
Sbjct: 3291 ELQDWM--TDAIH-----MLDSYCH----PTSDKSVLDSRTLKLEAL------------- 3326
Query: 414 ASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKN 473
SV Q+ + + + + T + +TS P P+ +L ++ W +L +
Sbjct: 3327 LSVKQE----KEIQMKMIVTRGESVLQNTS-------PEGIPTIQQQLQSVKDMWASLLS 3375
Query: 474 VISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDE 533
+ L AL + YQD ++ S M+++E L+ES +++ + ++ +
Sbjct: 3376 AGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQ----HAELRDKTTMLGK 3431
Query: 534 ILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE 593
+L +E+ SSL E + E A E Q L L ER I+ +A E
Sbjct: 3432 AKLLNEEVLSY-SSLLETI--EVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSE 3488
Query: 594 EKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNM 653
+ + E QR +A + WL + LD + E L D Q +
Sbjct: 3489 KLVRLHQEYQRDLKAFE----------VWLGQEQEKLDQYSVLEGDAHTHETTLRDLQEL 3538
Query: 654 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLN 713
V + L+ + E+++ G +D A L L+ Q L + +
Sbjct: 3539 QVHCAEGQALLNSVLHTREDVIPSGIPQAEDRA------LESLRQDWQAYQHRLSETRTQ 3592
Query: 714 MQGTAQEKEESDVDLTATQSPGVQEWL--AQARTTWTQQRQSS-------LQQQKELEQE 764
+ + L + V EWL A+ + + +RQS+ L Q K+ +E
Sbjct: 3593 FNNVVNK-----LRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEE 3647
Query: 765 LAEQKSLLRSVASRGEEILIQHSAAETSGDAG---------------EKPDVLSQELGME 809
+ + + V +R +EIL + G E+ L +E+
Sbjct: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3707
Query: 810 GEKSSAEDQMRMKWESLHQEF---STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGD 866
E S+ + S H+ F +TK + V+ ++ + L + G L K
Sbjct: 3708 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKS- 3766
Query: 867 VPTQDKSAVTSLLDG--------LNQAFEEVSSQSGGAKRQ------SIHLEQKLYDGVS 912
+ + AV L +G ++ E++ + +++ +HL ++ D
Sbjct: 3767 AREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCK 3826
Query: 913 ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 972
A + W+ + +E L V PEE + L+ ++ K + + + ++ +
Sbjct: 3827 ALTQWIAEYQEILHV-----PEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGE 3881
Query: 973 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 1032
++++D L ++ L S C KE + + D + + L + + +L
Sbjct: 3882 ALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLL 3939
Query: 1033 QKLANVFEQPVAE--QIEAIQQA-------EDGLKEFDAGIIELKRRGDKL--------- 1074
Q + + E +E I Q + + F+ + L+ +GD L
Sbjct: 3940 QMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ 3999
Query: 1075 -QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKM 1133
+++Q L +D Y + L L + LQ L Q +
Sbjct: 4000 AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL 4059
Query: 1134 AGDQKIIVSSKEEIQQL-----LDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHT 1188
+ +S E I+Q+ L + + L M K + +Q+ Q
Sbjct: 4060 EPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE 4119
Query: 1189 ELMAQASAVLKRAHKRGVELEYIL-ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENED 1247
+ + QA + + E++++ E W +L + Q+L S + + +
Sbjct: 4120 QKLVQAQNLTQGWE----EIKHLKSELWIYLQDADQQLQNMKR--RHSELELNIAQNMVS 4173
Query: 1248 RLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKM 1307
++ D + Q ++S+N K+ ++ + S ++N L + WL +
Sbjct: 4174 QVKDFVKKLQSKQASVNTIIEKVNKLTKKEE--------SPEHKEINHLNDQWLDLCRQS 4225
Query: 1308 SKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFL 1367
+ + E L+ Y D ++ ++ ++ F T+ + E HL A
Sbjct: 4226 NNLCLQREEDLQRTRDYH----DCMNVVEVFLEK--FTTEWDNLARSDAESTAVHLEALK 4279
Query: 1368 EFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL-RSELSRIDSQWTDLLTNIPA-VQEK 1425
+ + + + + +++ +D L + + S ++ +W L I +Q
Sbjct: 4280 KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVS 4339
Query: 1426 LHQLQ-MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 1484
+ L+ ++ + SR E+M W + I + +K S L + ++
Sbjct: 4340 VTNLEELNVVQSR--FQELMEWAEEQQPNIA---EALKQSPPPDMAQNLLMDHLAICSEL 4394
Query: 1485 NCKQLTVDFVNQSVLQISS-------QDVESKRSDKTDFAEQLGAM-NKSWQILQGLVTE 1536
KQ+ + + + ++ + Q ++ SD L + + + L ++E
Sbjct: 4395 EAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSE 4454
Query: 1537 KIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIK 1596
K Q L + ++ S+ + + + K + ++H V +K C+ + +K
Sbjct: 4455 KTQFLMAVFQATSQIQQH----------ERKIMFREHICLLPDDVSKQVKTCKSAQASLK 4504
Query: 1597 AKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN-LDHMVGQLKILLKSVLDQ 1655
+ EV + G L++ E S V+ L+EL + + L +L+ L K+++ +
Sbjct: 4505 TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4564
Query: 1656 WSSHKVAFDKINSYLMEARY-SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKF 1714
K FDK +L +A + L+ S E + Q+ QN+ + + E L
Sbjct: 4565 -KHFKEDFDKACHWLKQADIVTFPEINLMNESSE-LHTQLAKYQNILEQSPEYENLLLTL 4622
Query: 1715 GSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQ 1774
+L + L+ L + ++N ++ ++ + + + Y +
Sbjct: 4623 QRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIEL 4682
Query: 1775 CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLK---GLGTVKDSLFFLHELG 1831
++ + E + + K T D+A +E + C +L GLG D L
Sbjct: 4683 TTQSLSELEAQFLRMSKVPT--DLAVEEALSLQDGCRAILDEVAGLGEAVDEL------- 4733
Query: 1832 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD-----YETFAKSLE 1886
K++ S Q D++ HL L L K+QT + +L+ Y+ K +
Sbjct: 4734 -NQKKEGFRSTGQPWQPDKML---HLVTLYHRL-KRQTEQRVSLLEDTTSAYQEHEKMCQ 4788
Query: 1887 ALEAWIVEA--------EEILQGQDP--SHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 1936
LE + EE L ++ + S ++Q+ LK + +AP LD
Sbjct: 4789 QLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDP 4848
Query: 1937 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFL 1996
L +K ++Q+ L++S E ++ +S ++Q F + +++L
Sbjct: 4849 L--------AYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWL 4900
Query: 1997 VQTEQKLA--VEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDR 2054
+ + +L+ V + N Q + E+ R ++ Q E+ S +I++++ + + +
Sbjct: 4901 RRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELIS 4960
Query: 2055 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS-YLPMSG 2113
+ L LS + + R+ + Q QRY ++ + WL + L ++G
Sbjct: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG 5020
Query: 2114 LG----SVPIPLQQARTLFD-EVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQ 2168
G S L+ F E QF L + S + T++ L +G E L+
Sbjct: 5021 NGLDVESAEENLKSHMEFFSTEDQFHSN--LEELHSLVATLDP-----LIKPTGKED-LE 5072
Query: 2169 AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQ-SLPDH 2227
++A ++ + + S Q L W +K + +E + +KKLS+ SL
Sbjct: 5073 QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKT 5132
Query: 2228 HEELHAEQMRC--KELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQW 2285
AE+ K L + V S+ + + L L + + L+ + + ++W
Sbjct: 5133 SSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRW 5192
Query: 2286 EELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV-------SQNGDILI--- 2335
L + + + + ++EW F+ K K+ E + Q++ K+ + ++L
Sbjct: 5193 TRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLE 5252
Query: 2336 --EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHL 2393
+ + +L++ Q + + ++ + + Q G EI + DR ++
Sbjct: 5253 YHDTFVLELEQQ-QSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEIT----AMQDRCLNM 5307
Query: 2394 LDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQ 2453
+ + K +K+ L + ++ ++S++ W+ + L P + EE+Q L E
Sbjct: 5308 QEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEA 5367
Query: 2454 QELQRDIEK 2462
+++IEK
Sbjct: 5368 TNHRQNIEK 5376
Score = 132 bits (333), Expect = 4e-30
Identities = 621/3292 (18%), Positives = 1212/3292 (36%), Gaps = 545/3292 (16%)
Query: 83 ASQLREQY-ILHQTLLEESKEIDSELEAMTEKLQYLTSVY----CTEKMSQQVAELGRET 137
A+QL +Y L +LE+ K ++ E++++ E L+S T K + VA +
Sbjct: 3679 ATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
Query: 138 EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQ 197
+ + M+ +L+ L+ KDM+K + LK + E+A L E RL R+
Sbjct: 3739 DTV--MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERL--------RK 3788
Query: 198 HLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIM 257
+ ME LK V+ L L L +E S +C +
Sbjct: 3789 EIHDHMEQLKELTSTVRKEHMTLE-------------KGLHLAKEFS-------DKCKAL 3828
Query: 258 QAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQE 317
+ +Y QE+ H+ + E K + E +AQ+S+++ L Q + ++
Sbjct: 3829 TQWIAEY----QEILHVPE---------EPK----MELYEKKAQLSKYKSLQQTVLSHEP 3871
Query: 318 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRC 377
+ S+ K + L + T+ +++ L +DL + G+
Sbjct: 3872 SVKSVREKGEALLELVQDVTLK---DKIDQLQSDYQDL----------------CSIGKE 3912
Query: 378 HTLLSPVTEESGEEGTNSEISSPP------ACRSPSPVANTDAS---VNQDIAYYQALSA 428
H + S + E NSE+ + R +P +S + Q +A+++A+
Sbjct: 3913 H-VFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME 3971
Query: 429 E------RLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTL 482
E RL K + + L+ + A L + S+ + + ++L
Sbjct: 3972 EIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSL 4031
Query: 483 YEALERQQKYQDSLQSISTKMEAIELKLSESPEP--GRSPESQMAEHQALMDEILMLQDE 540
L++ QD+LQ + A++ L SP+P R+ + +H + E
Sbjct: 4032 EHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE------- 4084
Query: 541 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 600
Q+ +L+ C+ A + T Q +E+KL +
Sbjct: 4085 ----QARTYLDLLCSMCDLSNAS--------------VKTTAKDIQQTEQTIEQKL---V 4123
Query: 601 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 660
+ Q Q + + EL W+ A D L K E +L QNM+ +++
Sbjct: 4124 QAQNLTQGWEEIKHLKSEL--WIYLQDA--DQQLQNMKR-RHSELELNIAQNMVSQVKDF 4178
Query: 661 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720
V L ++ + TK E ++ L L+L R ++ L + Q
Sbjct: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
Query: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS-------LQQQKELEQELAEQKSLLR 773
+ + V+ +L + T W +S L+ K+L L E+K +
Sbjct: 4239 TRDYHDCMNV-----VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIE 4293
Query: 774 SVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE---SLHQEF 830
+ + ++ +I+H + +K V Q +E ED ++ K + + +E
Sbjct: 4294 DLKDQKQK-MIEHL------NLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEEL 4346
Query: 831 STKQKLLQNVLEQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTS-------LLD 880
+ Q Q ++E +EQ +PN L P D A+ S LL
Sbjct: 4347 NVVQSRFQELMEWAEEQ----QPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLK 4402
Query: 881 GLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCL 940
L + + V + G +RQ I ++ L D S + D V +R L E+T
Sbjct: 4403 SLIKDADRVMADLGLNERQVI--QKALSDAQSHVNCLSDLVGQRRKYLNKALSEKT---- 4456
Query: 941 FNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSL--LDSVVNQ 998
Q ++A + + K +F + D DV + C + SL + V
Sbjct: 4457 --QFLMAVFQATSQIQQHERKIMFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTG 4512
Query: 999 RCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL- 1057
Q +E ++++ Q +VL LQ+L +V++ + + +Q+ E L
Sbjct: 4513 LWAQGRELMKEVTE-QEKSEVLGK---------LQELQSVYDSVLQKCSHRLQELEKNLV 4562
Query: 1058 ------KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111
++FD LK+ E M E S+L + I+ N LTL
Sbjct: 4563 SRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTL 4622
Query: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 1171
+R Q + L ++ + + + L K K Y IL
Sbjct: 4623 ----QRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY---KVQEAILARKE 4675
Query: 1172 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE----YILETWSHLDEDQQELSR 1227
+ +I Q ++ + + + A + + L+ IL+ + L E EL++
Sbjct: 4676 YASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQ 4735
Query: 1228 QLEVVESSIPSVGLVEENEDRLIDRITLYQHLKS------SLNEYQPKLYQVLDDGKRLL 1281
+ E S+ D+++ +TLY LK SL E YQ +
Sbjct: 4736 KKEGFRSTGQ-----PWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK----- 4785
Query: 1282 ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDR 1341
C LE QL + E +K+++E E LK + D L+
Sbjct: 4786 ---MCQQLERQLKSVKE----EQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4838
Query: 1342 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 1401
LE P E R + ++ K + S++ +V +++++ T
Sbjct: 4839 LEDLAPH--LDPLAYEKARHQIQSWQGELKLL--TSAIGETVTECESRMVQSIDFQTEMS 4894
Query: 1402 RS--ELSRIDSQWTD---LLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQK 1456
RS L R+ ++ + L N+ +QE++ ++Q+ + EV S + +M + K
Sbjct: 4895 RSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ-------EEVQSSLRIMNALSHK 4947
Query: 1457 DEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQD---VESKRSDK 1513
+++ + K+L + S+ ++S D E+ R+ +
Sbjct: 4948 EKEKFTKA----------------------KELISADLEHSLAELSELDGDIQEALRTRQ 4985
Query: 1514 TDFAEQLGAMNKSWQILQGL------VTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 1567
E + +Q+ Q E +QL L+ S E N++ +F T+++
Sbjct: 4986 ATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESA-EENLKSHMEFFSTEDQ 5044
Query: 1568 ---RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIV 1624
L++ H + L+ LIK KE + ++ V+S+
Sbjct: 5045 FHSNLEELHSL------------VATLDPLIKPTGKE-------------DLEQKVASLE 5079
Query: 1625 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL- 1683
+ + R + A +D LL+ QW ++ A +++ + + LS F LL
Sbjct: 5080 LRSQRMSRDSGAQVD--------LLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLK 5131
Query: 1684 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 1743
T S + ++ + L + + +QL K + TL+ ++ V R
Sbjct: 5132 TSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQR 5191
Query: 1744 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEV 1803
W L +Q + + + W + + K+ + Q +D+ L ++ + + E+
Sbjct: 5192 WTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDK----LPGSSAEKASKAEL 5247
Query: 1804 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 1863
T ++ + + L + +L L + + Q A+ ++ L Q + A++
Sbjct: 5248 LTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DGAAPTPGEEPPLMQEITAMQDR 5303
Query: 1864 LCKQQTSLQAG-------VLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQ-- 1914
Q ++ + D E + +++ W+ E +E L + L +Q
Sbjct: 5304 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQIL 5363
Query: 1915 -----------ERM-EELKGQMLKFSSMAP-DLD-RLNELGYRLPLNDKEIKRMQNLNRH 1960
E+M EE K + L ++ P +L +L E+ L + D+ +++ + +
Sbjct: 5364 LTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQ- 5422
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQ--TEQK-LAVEISGNYQHLLEQ 2017
S +SQ R ++Q T L K + + +VQ T+QK L E+ G L+E
Sbjct: 5423 -SKATSQELSR--QIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMEL 5479
Query: 2018 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQ 2077
A + F L + GQ+ K+ L+ Q IR+A+
Sbjct: 5480 DAAVQKF--------------------LEQNGQLG--KPLAKKIGKLTELHQQTIRQAEN 5517
Query: 2078 RRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV 2137
R ++ + Y EM E + KW+ + L + +
Sbjct: 5518 RLSKLNQAASHLEEYNEMLELILKWIEKAKVL-----------------AHGTIAWNSAS 5560
Query: 2138 FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQ--------EKWKSASMRLEEQK 2189
LR+Q YIL Q LL ++ L+A ++Q EK L +
Sbjct: 5561 QLREQ--YIL-----HQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRET 5613
Query: 2190 KKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWT 2249
++L ++K + + A ++K KKL +L L + ++ L+ +
Sbjct: 5614 EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQ 5673
Query: 2250 DDLTQLSLLKDTLSA-YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 2308
L+++ LK + A + + I + V L LCH +LR Q+ RL A+
Sbjct: 5674 HLLSEMESLKPKVQAVQLCQSALRIPEDVVASL-----PLCH-AALRLQEEASRLQHTAI 5727
Query: 2309 ---------------FSEKNKELCEWL----TQMESKVSQNGDI--------LIEEMIEK 2341
+ ++ K L + + ++E K +I EE+ +K
Sbjct: 5728 QQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQK 5787
Query: 2342 LKKDYQEEIAIAQENKIQLQQMGERLAKASHES---KASEIEYKLGKVNDRWQHLLDLIA 2398
+ K YQE+IA + +K ++ M KA H + +E+E D LL +
Sbjct: 5788 I-KGYQEQIA-SLNSKCKMLTM-----KAKHATMLLTVTEVEGLAEGTEDLDGELLPTPS 5840
Query: 2399 ARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR 2458
A + T L ++ + SE++ P +C S N + +
Sbjct: 5841 AHPSVVMMTAGRCHTLLSPVTE-ESGEEGTNSEISSP---PACRSP--SPVANTDASVNQ 5894
Query: 2459 DIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR----NLDRRWRNICAMSMER 2514
DI + A L +H + + + ++ + +L R W + + E+
Sbjct: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEK 5954
Query: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 2574
+ + E QK+ D +++ E + G + + Q +
Sbjct: 5955 QRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG------RSPESQMAEHQALMD 6008
Query: 2575 ECLTQLELINKQYRRLARENRTDSA-------CSLKQMVHEGNQRWDNLQKRVTSILRRL 2627
E L + IN+ LA E ++S +L+ + +R ++ + + + L
Sbjct: 6009 EILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLL 6068
Query: 2628 KHFIG-----QREE-----FETARDSILVWL--TEMDLQLTNIEHFSECDVQAKIKQLKA 2675
+ + QR+E + D + WL T+ L D++A++ +
Sbjct: 6069 EEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 6128
Query: 2676 FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI 2735
EI + ++ E L+ + + E+ +LRR + H K +
Sbjct: 6129 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQL 6188
Query: 2736 RLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS-NLSLSLAQPLRSERS 2794
+ E + SD +L S + + W ++ + + SS L Q L ++S
Sbjct: 6189 NMQGTAQEKEESDVDLTATQSPGVQE--WLAQARTTWTQQRQSSLQQQKELEQELAEQKS 6246
Query: 2795 GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSA 2854
+ AS E + + +E +K L +G+ G+ S+
Sbjct: 6247 LLRSVASRG----------------EEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSS 6290
Query: 2855 LESQIRQLGKALDDSRFQIQQ--TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 2912
E Q+R ++L F +Q +N++ + L + + V
Sbjct: 6291 AEDQMRMKWESL-HQEFSTKQKLLQNVLEQEQE------------QVLYSRPNRLLSGVP 6337
Query: 2913 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD 2972
+ + +++S + + G+ +E + +Q+ + +Q++ Q+
Sbjct: 6338 LYKGDVPTQDKS--------AVTSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDG 6386
Query: 2973 LNSIWAWLGDTEEELEQLQRL---ELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 3029
+++ WL D EE L L E T + E+ K +KE+ + +D K NL
Sbjct: 6387 VSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNK------NLF 6440
Query: 3030 SPEFTQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 3088
S F ++ ++RD ++D L + GR + S++ + +++ L Q F + L +
Sbjct: 6441 SQAF--PENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNF---QNDLKV 6495
Query: 3089 MLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAE 3148
+ ++ K I+ +N+ + + + + + Q + L E + L+ +L V
Sbjct: 6496 LFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP 6555
Query: 3149 GTDCLEAKEKVH-----VIGNR---LKLLLKEVSRHIKELEKLLDVSSSQQD 3192
L + ++ +IG+R L L S++ + L+ L D+ + Q+
Sbjct: 6556 SMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6607
Score = 126 bits (317), Expect = 3e-28
Identities = 548/3098 (17%), Positives = 1187/3098 (38%), Gaps = 401/3098 (12%)
Query: 266 QYEQEMKH-LQQLIEGAH--REIEDKPVATSNIQELQAQISRHEELAQKI----KGYQEQ 318
QY++ +K+ L++LI G+ +E +K + T N+ E Q + H++ ++I + Q+Q
Sbjct: 1236 QYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQ 1295
Query: 319 IASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 378
IA L + H + + ++GL E + + V + R
Sbjct: 1296 IAQAQQGEGGLPDRG-HEELRKLESTLDGLERSRERQERRI--------QVTLRKWERFE 1346
Query: 379 TLLSPVTEESGEEGTNSE----ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 434
T V + G++ E SS + S + + IA + AE L +
Sbjct: 1347 TNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIA----VQAENLVKE 1402
Query: 435 AAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
A++I P LQ+ +++K + + + TL E ++ + +
Sbjct: 1403 ASEI----------------PLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1446
Query: 495 SLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS---LAEE 551
+ E + + ++E + + E+ + + +I + EI SS L EE
Sbjct: 1447 KWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEE 1506
Query: 552 LVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQ-EQALQ 610
S + E +++ LT + +R A Q LE + L +Q++ E+ L+
Sbjct: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHA----QCLEGTILGHLSQQQKFEENLR 1562
Query: 611 RYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELS-- 668
+ + E + L A S E + + MD L + + A S +
Sbjct: 1563 KIQQSVSEFEDKL----AVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARK 1618
Query: 669 VHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDL 728
V N + ++ A + + E + LRR K E Q AL + + Q EKE S L
Sbjct: 1619 VVNRDSCVQEAAALQQQYEDI---LRRAK----ERQTALENLLAHWQRL--EKELSSF-L 1668
Query: 729 TATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA 788
T WL + + + ++E EL ++L V S+
Sbjct: 1669 T---------WLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQL 1719
Query: 789 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQE-- 846
E+ K DV +L +E Q+ +W L Q + + LQ+V+ + Q+
Sbjct: 1720 KESLFSVASKDDVKMMKLHLE--------QLDERWRDLPQIINKRINFLQSVVAEHQQFD 1771
Query: 847 QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFE---EVSSQSGGAKRQSIHL 903
++L S + L+ ++ T + ++ L + + EV S+ G + HL
Sbjct: 1772 ELLLS----FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHL 1827
Query: 904 EQKLYDGVSATSTWLDDVEE---RLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 960
+ G + L E +LF + + E + L + + +S + +
Sbjct: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
Query: 961 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020
+ N + D+IE L L L+S + + + ++ +
Sbjct: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947
Query: 1021 FTSLADNKYIILQKLANVF--EQPVAEQIEAIQQA-EDGLKEFDAGIIELKRRGDKLQVE 1077
+ AD ++++ N+ +Q A+ + +++A +D +E I +++ R DK +++
Sbjct: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
Query: 1078 QPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ-DLADLLETGQE----K 1132
+P+ Q L + ++++L + S L LK + ++ Q D+A E +E +
Sbjct: 2008 EPTRQALQQRLRVFNQLEDELNSHEHEL---CWLKDKAKQIAQKDVAFAPEVDREINRLE 2064
Query: 1133 MAGD--QKIIVSSKEEIQQLLDKHKEYFQGLESHMI-LTETLFRKIISFAVQKETQFHTE 1189
+ D +++I ++ + L+D +EY Q L+S + + E I++ K+ +
Sbjct: 2065 VTWDDTKRLIHENQGQCCGLIDLMREY-QNLKSAVSKVLENASSVIVTRTTIKDQEDLKW 2123
Query: 1190 LMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL-SRQLEVVESSIPSV--------G 1240
++ + + + +L+ HL + +++ S +V++ + S
Sbjct: 2124 AFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSE 2183
Query: 1241 LVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECW 1300
+EEN DRL ++++ + S+ +E + + + ++ +L + E
Sbjct: 2184 KLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESE 2243
Query: 1301 LSNTNKMSKELHRLETILKHWTR-------YQSESADLIHWLQSAKDRLEFWTQQSVTVP 1353
+ N +ELH LK T+ Q ADL+ L+ AK+ E
Sbjct: 2244 VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFT 2303
Query: 1354 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWT 1413
+ V +N + +V+ +S + + T L ++K + L+S+ S I S
Sbjct: 2304 AQSTQVEKFINDITTWFTKVE-ESLMNCAQNETCEALKKVKDIQKE-LQSQQSNISSTQE 2361
Query: 1414 DLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEY 1473
N+ ++ K H +++ L A++ ++ + + K + +++ S+ K E
Sbjct: 2362 ----NLNSLCRKYHSAELESLG--RAMTGLIKKHEAVSQLCSKTQASLQESLE-KHFSES 2414
Query: 1474 LQKYKGFKIDINC--KQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQ 1531
+Q+++ + + K+ + + VL+ D+++ +D +L A+ + Q L
Sbjct: 2415 MQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY 2474
Query: 1532 GLVTEKI--QLLEGLLESWSEYENNV-QCLKTW------------FETQEKRLKQQ-HRI 1575
++++I + E + ++ E++ + QCLK FE Q ++L H +
Sbjct: 2475 AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEM 2534
Query: 1576 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTW 1635
++ + +N + Q + + K+ EV K+E L+ ++ + L + GQ
Sbjct: 2535 EERFNTENLGESKQHIPE----KKNEVHKVEMFLGELLAARES------LDKLSQRGQLL 2584
Query: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV- 1694
+ H GQ L +L +SH+ L + +L L +L+++ V
Sbjct: 2585 SEEGHGAGQEGRLCSQLL---TSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVK 2641
Query: 1695 ---DNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751
D L + L ++ ++ I + LL + V + E +R +N +
Sbjct: 2642 AIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQR 2701
Query: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCN 1811
Q Q + L ++W S ST++ + N+ ++ +++ W++ +
Sbjct: 2702 VIQTQL-ETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK-------NQLEQWMESVD 2753
Query: 1812 DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSL 1871
++ H L Q + +QS H AL + + K +
Sbjct: 2754 QKIE------------HPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSR--- 2798
Query: 1872 QAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI-QERMEELKGQMLKFSSM 1930
E + K+ + E++ A+E L+ Q +D+ T+ +E+M +++ +++K M
Sbjct: 2799 -------ELYEKTED--ESFKDTAQEELKTQ----FNDIMTVAKEKMRKVE-EIVKDHLM 2844
Query: 1931 APDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990
LD ++E L +E+ R +++ SS T ++ SK++ + + +
Sbjct: 2845 Y--LDAVHEFTDWLHSAKEELHRWSDMSGD----SSATQKKLSKIKELIDSREIGASRLS 2898
Query: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAH-ELFQAEMFSRQQILHSIIIDGQRLLEQ- 2048
+ +Q ++ RA + ++ +F Q L +++ L EQ
Sbjct: 2899 RVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQ-MALSEQE 2957
Query: 2049 --GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQ-WQRYREMAEKLRKWLVE 2105
GQV ++ + + L W + + + D +I + W + +E+ + L+K
Sbjct: 2958 FSGQVAQLEQALEQFSALLKTWAQQLTLLEGKN--TDEEIVECWHKGQEILDALQK---- 3011
Query: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA 2165
+ ++ +E+ + G ++ L L A G +
Sbjct: 3012 -----------AEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN 3060
Query: 2166 ALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 2225
Q ++ ++ L K A KC I ++ ++ T +K+ + L
Sbjct: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTA-------KCFD-IPQNISEVSTSLQKIQEFLS 3112
Query: 2226 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQW 2285
+ H M + E LS ++ + + +V + W
Sbjct: 3113 ESENGQHKLNMMLSKGE------------------LLSTLLTKEKAKGIQAKVTAAKEDW 3154
Query: 2286 EELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG----DILIEEMIEK 2341
+ L + + + F + + +WL++ E V ++ D+ + ++
Sbjct: 3155 KNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQ 3214
Query: 2342 LKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 2401
+ EEI + +L++ ++L + SK+ +++ +++ ++ L +L +V
Sbjct: 3215 KLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS--FRHRVSQLSSQYLALSNLTKEKV 3272
Query: 2402 KKLKETLVAVQQLDKNMSSLRTWLA---HIESELAKPI----VYDSCNSEEIQRKLNEQQ 2454
+L + Q + L+ W+ H+ P V DS + +++ L+ +Q
Sbjct: 3273 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDS-RTLKLEALLSVKQ 3331
Query: 2455 ELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 2514
E + ++ T SVL + +IQQ +++ W ++ + +
Sbjct: 3332 EKEIQMKMIVTRGESVLQN-----------TSPEGIPTIQQQLQSVKDMWASLLSAGIRC 3380
Query: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 2574
+ ++E W + D +F W+ S E E ++ A R
Sbjct: 3381 KSQLEGALSKWTSYQDGVRQFSGWMDSMEANL--------------NESERQHAELRDKT 3426
Query: 2575 ECLTQLELINKQ---YRRLARENRTDSACSLKQMV-----HEGNQRWDNLQKRVTSILRR 2626
L + +L+N++ Y L A + V + +R+ +Q+R + +
Sbjct: 3427 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3486
Query: 2627 LKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK-----IKQLKAFQQEIS 2681
+ + +E++ + VWL + + ++ +S + A ++ L+ Q +
Sbjct: 3487 SEKLVRLHQEYQRDLKAFEVWLGQ---EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCA 3543
Query: 2682 LNHNKIEQIIAQGEQLIEKSEP-LDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLP 2740
+ ++ E +I P + +E + + Y + +++ + +L L
Sbjct: 3544 EGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLM 3603
Query: 2741 DDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPA 2800
+ + D L ++A+ +SP R+ R +
Sbjct: 3604 EQKFQQVDEWL---------------KTAEEKVSP-----------------RTRRQSNR 3631
Query: 2801 SVDSIPL----EWDHDYDLSRD-LESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSAL 2855
+ I L +W + RD +E +RA DE + + A L+ + AL
Sbjct: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQAL 3689
Query: 2856 ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSI--DSVKR 2913
Q+ + K L++ ++++E+ + S + ++K + + + + +K
Sbjct: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749
Query: 2914 LEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR--------------- 2958
LE LK+ E+ G L S + + E +A+ L KE+
Sbjct: 3750 LEVLLKDMEK---GHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRK 3806
Query: 2959 ----MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQK 3014
+++ L ++F+ ++ W+ + +E L + E ++ + Q+ K K LQ+
Sbjct: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE--EPKMELYEKKAQLSKYKSLQQ 3864
Query: 3015 AVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM 3074
V + + S+ + + L+D++ Q+ + +CS+ +E L+ +
Sbjct: 3865 TVLSHEPSVKSVREKGEALLEL--VQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
Query: 3075 QCQGFH-EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ-DHHKQLMQIKHELLESQLR 3132
+ ++ E+ +L+ R + S+L+ Q HHK +M+ E+ + R
Sbjct: 3923 DHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME---EIAGFEDR 3979
Query: 3133 VASLQDMSCQLLVNAEGTDCLEAKEK----VHVIGNR--LKLLLKEVSRHIKELEKLLDV 3186
+ +LQ L+ + D L+AK K H+ G + + R + LE L
Sbjct: 3980 LNNLQMKGDTLI--GQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 4037
Query: 3187 SSSQQDL----SSWSSADELDTSGSVSPTSGRSTPNRQ 3220
S+QD +W SA + D S P R+ +Q
Sbjct: 4038 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQ 4075
Score = 105 bits (261), Expect = 1e-21
Identities = 396/2090 (18%), Positives = 783/2090 (37%), Gaps = 300/2090 (14%)
Query: 1137 QKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAV-----QKETQFHTELM 1191
Q++ + IQ+ L++HK+ Q ++H ++R + Q E
Sbjct: 432 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 491
Query: 1192 AQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLID 1251
+++ L +EL+Y L + L E + ++S I G E E L +
Sbjct: 492 VSSTSELHLMKMEFLELKYRLLSLLVLAESK---------LKSWIIKYGRRESVEQLLQN 542
Query: 1252 RITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQ-----LNQLGECWLSNTNK 1306
++ ++ S E YQ+L + + S E++ +N+ W + + +
Sbjct: 543 YVSFIEN--SKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE 600
Query: 1307 MSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL--------EFWTQQSVTVPQELEM 1358
+ LE ++ +W RY + A L WL+ A+ L +F+ + Q M
Sbjct: 601 VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 660
Query: 1359 VRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTN 1418
D N +E E+ ++ + +L G +V E+ R+ ++TD +
Sbjct: 661 -NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT 719
Query: 1419 IPAVQEKLHQLQMDKLPSRHA--------ISEVMSWISLME---NVIQKDEDNIKNSIGY 1467
+ A + H+ + L + ++ + +M+ +I K I
Sbjct: 720 LSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQ 779
Query: 1468 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV----ESKRSDKTDFAEQLGAM 1523
+ E K +QLT S L SQ + E T F + LG +
Sbjct: 780 EEGKEMFATMSKLK-----EQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKI 834
Query: 1524 NKSWQILQ------GLVTEKIQLL----EGLLESWSEYENNVQCLKTWFETQEKRLKQ-- 1571
N+ +L+ L +K Q L E ++ + E Q ++ F T LK
Sbjct: 835 NEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQK-FVTLSNVLKHFD 893
Query: 1572 ----QHRIGD-QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMS 1626
Q +I D + Q+ +K D + ++ + ++K E++ L E V I
Sbjct: 894 QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAEL-----EKVLRIAQE 948
Query: 1627 TLRELG----------QTWANLDHMVGQLKILLKS------VLDQWSSHKV--AFDKINS 1668
L E G + ++ LD V L LK+ +L + + A K++
Sbjct: 949 GLEEKGDPEELLRRHTEFFSQLDQRV--LNAFLKACDELTDILPEQEQQGLQEAVRKLHK 1006
Query: 1669 -----------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNL--QDDLEKQERSLQKFG 1715
+L+ + + + R L S+E + ++D L Q+ EK + + F
Sbjct: 1007 QWKDLQGEAPYHLLHLKIDVEKNRFLA-SVEECRTELDRETKLMPQEGSEKIIKEHRVFF 1065
Query: 1716 SITN---------QLLKEC------HPPVTETLTN---TLKEVNMRWNNLLEEIAEQLQS 1757
S QL++E PV +T TLKE+ ++ ++ E
Sbjct: 1066 SDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK 1125
Query: 1758 SKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI--ADDEVATWIQDCNDLLK 1815
K R+ ++S ++ Q + E + A + ++ A +E+ + + L
Sbjct: 1126 WK---DYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLS 1182
Query: 1816 GLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQAL-----CKQQTS 1870
L K L L E+ + + Q + + S +L L +E+ L C Q
Sbjct: 1183 WL---KSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKE 1239
Query: 1871 LQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSM 1930
+ L+ E + S E E +AE+IL ++ + L + ++ K K +
Sbjct: 1240 IVKNSLE-ELISGSKEVQE----QAEKILDTENLFEAQQL--LLHHQQKTKRISAKKRDV 1292
Query: 1931 APDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990
+ + + LP D+ + ++ L + + ++Q L + + F E
Sbjct: 1293 QQQIAQAQQGEGGLP--DRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
Query: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 2050
T + +L QT +S + L EL Q + FS++ SI + + L+++
Sbjct: 1351 TVVRYLFQTGSSHERFLSFSSLESLSS----ELEQTKEFSKRT--ESIAVQAENLVKEAS 1404
Query: 2051 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR-------QWQRYREMAEKLRKWL 2103
N +L L Q + + + ++ ++ I+ +W + E L W+
Sbjct: 1405 EIPLGPQNKQL--LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWI 1462
Query: 2104 VE----VSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSA 2159
E ++ L S ++ + + Q + E++ K S + E +
Sbjct: 1463 TEKEKELNALETSS-SAMDMQISQIKVTIQEIESK-------LSSIVGLEEEAQSFAQFV 1514
Query: 2160 DSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK 2219
+G A ++A+L +I+ R E+ ++ A L E G +K +K
Sbjct: 1515 TTGESARIKAKLTQIR--------RYGEELREHAQCL---EGTILGHLSQQQKFEENLRK 1563
Query: 2220 LSQSLPDHHEELHAEQMRCK---ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN- 2275
+ QS+ + ++L C E + D L L ++A+ SA ++N
Sbjct: 1564 IQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAF-SASARKVVNR 1622
Query: 2276 ----ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ-- 2329
+ LQ+Q+E++ + R+ + L W ++ WL + E+K S
Sbjct: 1623 DSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPE 1682
Query: 2330 ---NGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKV 2386
+ D + E +L + Q E+ +L Q+ E L + + ++ L ++
Sbjct: 1683 MDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQL 1742
Query: 2387 NDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK-----------P 2435
++RW+ L +I R+ L+ + QQ D+ + S W+ SEL
Sbjct: 1743 DERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA 1802
Query: 2436 IVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGVASVLNLCEVLLHDCDACATDAE--CDS 2492
+ ++ E++ K E Q LQ + K S G A L+L + DC +A +
Sbjct: 1803 LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVER 1862
Query: 2493 IQQATRNLDRRWRNICAMS---MERRLKIEETWRLWQKFLDDYSR-FEDWLKSSERTAAF 2548
Q A +L ++ ++S + R +E T + + D + D L++++ +
Sbjct: 1863 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESA 1922
Query: 2549 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-----ARENRTDSACSLK 2603
S I + A+ LK + QR C + + + R+ +++ D+ LK
Sbjct: 1923 AVSLDGILSKAQYHLKIGSSEQRT--SCRATADQLCGEVERIQNLLGTKQSEADALAVLK 1980
Query: 2604 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 2663
+ + + + L K + I R +E A L +++ +L + EH
Sbjct: 1981 KAFQD---QKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDELNSHEH-EL 2035
Query: 2664 CDVQAKIKQLK----AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE--EELDELR 2717
C ++ K KQ+ AF E+ N++E ++LI +++ +I+ E L+
Sbjct: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
Query: 2718 RYCQEVFGRVERYHKKLIRLPLPDDEHDL--------------SDRELELEDSAA----- 2758
+V +E ++ D+ DL + ++ +L++ +
Sbjct: 2096 SAVSKV---LENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHL 2152
Query: 2759 LSDLHWHDRSADSLLSPQPSSNLS--LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS 2816
LS+L S SL+ S + L +++ L S+ WD
Sbjct: 2153 LSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSI------WDDVLSTR 2206
Query: 2817 RDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQT 2876
++E + +P + E + D +LR L ES+++ L++ ++
Sbjct: 2207 DEIEGWSNNCVP-QMAENISNLDNHLRAEELL----KEFESEVKNKALRLEELHSKVNDL 2261
Query: 2877 ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 2936
+ + ++ T P+L D +++LEH + E + + + T
Sbjct: 2262 KELTKN-LETPPDLQ-------------FIEADLMQKLEHAKEITEVAKGTLKDFTAQST 2307
Query: 2937 QTAGVIDRWELLQAQALSKELRMKQN-----LQKWQQFNSDLNSIWAWLGDTEEELEQLQ 2991
Q I+ + + QN L+K + +L S + + T+E L L
Sbjct: 2308 QVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLC 2367
Query: 2992 RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 3041
R S +++++ + L + +AV LCS TQA +ES
Sbjct: 2368 RKYHSAELESLGRAMTGLIKKHEAVS---------QLCSK--TQASLQES 2406
Score = 41.6 bits (96), Expect = 0.013
Identities = 46/220 (20%), Positives = 81/220 (36%), Gaps = 45/220 (20%)
Query: 2920 EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 2979
EE E++ F+N ET +W L + S +++ + W ++ + + S+ AW
Sbjct: 578 EEAENVMKFMN----ETTA-----QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAW 628
Query: 2980 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 3039
L D E+ L Q + + + L + A+ + N D
Sbjct: 629 LEDAEKMLNQSENAKKDF-----------FRNLPHWIQQHTAMNDAGNFL---IETCDEM 674
Query: 3040 ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNE 3099
SRDL+ +L +NGR WR L + Q + +DR K E
Sbjct: 675 VSRDLKQQLLLLNGR----------WRELFMEVKQYAQA------------DEMDRMKKE 712
Query: 3100 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 3139
L A + H K ++ + +L + L+D+
Sbjct: 713 YTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDI 752
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 6468 bits (16780), Expect = 0.0
Identities = 3321/3344 (99%), Positives = 3321/3344 (99%), Gaps = 23/3344 (0%)
Query: 1 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML
Sbjct: 5406 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 5465
Query: 61 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 120
ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV
Sbjct: 5466 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 5525
Query: 121 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180
YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT
Sbjct: 5526 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5585
Query: 181 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 240
SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ
Sbjct: 5586 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 5645
Query: 241 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 300
EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA
Sbjct: 5646 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 5705
Query: 301 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 360
QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL
Sbjct: 5706 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 5765
Query: 361 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 420
PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI
Sbjct: 5766 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 5825
Query: 421 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 480
AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR
Sbjct: 5826 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 5885
Query: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 540
TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE
Sbjct: 5886 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 5945
Query: 541 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 600
INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL
Sbjct: 5946 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 6005
Query: 601 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 660
EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK
Sbjct: 6006 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 6065
Query: 661 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720
VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE
Sbjct: 6066 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 6125
Query: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 780
KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE
Sbjct: 6126 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 6185
Query: 781 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 840
EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV
Sbjct: 6186 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 6245
Query: 841 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 900
LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS
Sbjct: 6246 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 6305
Query: 901 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 960
IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN
Sbjct: 6306 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 6365
Query: 961 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020
KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL
Sbjct: 6366 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 6425
Query: 1021 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 1080
FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS
Sbjct: 6426 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 6485
Query: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII
Sbjct: 6486 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6545
Query: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 1200
VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR
Sbjct: 6546 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 6605
Query: 1201 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 1260
AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK
Sbjct: 6606 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6665
Query: 1261 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 1320
SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH
Sbjct: 6666 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 6725
Query: 1321 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 1380
WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK
Sbjct: 6726 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6785
Query: 1381 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 1440
SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI
Sbjct: 6786 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 6845
Query: 1441 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 1500
SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ
Sbjct: 6846 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 6905
Query: 1501 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 1560
ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT
Sbjct: 6906 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 6965
Query: 1561 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620
WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV
Sbjct: 6966 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 7025
Query: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680
SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF
Sbjct: 7026 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 7085
Query: 1681 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 1740
RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV
Sbjct: 7086 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 7145
Query: 1741 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 1800
NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD
Sbjct: 7146 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 7205
Query: 1801 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 1860
DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL
Sbjct: 7206 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 7265
Query: 1861 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 1920
EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL
Sbjct: 7266 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 7325
Query: 1921 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 1980
KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL
Sbjct: 7326 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 7385
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII
Sbjct: 7386 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7445
Query: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR
Sbjct: 7446 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7505
Query: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD
Sbjct: 7506 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7565
Query: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 2220
SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL
Sbjct: 7566 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 7625
Query: 2221 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 2280
SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL
Sbjct: 7626 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 7685
Query: 2281 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 2340
LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE
Sbjct: 7686 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 7745
Query: 2341 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 2400
KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR
Sbjct: 7746 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 7805
Query: 2401 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 2460
VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI
Sbjct: 7806 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 7865
Query: 2461 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 2520
EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE
Sbjct: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
Query: 2521 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL
Sbjct: 7926 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 7985
Query: 2581 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 2640
ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA
Sbjct: 7986 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 8045
Query: 2641 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK
Sbjct: 8046 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 8105
Query: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 2760
SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS
Sbjct: 8106 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 8165
Query: 2761 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 2820
DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE
Sbjct: 8166 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 8225
Query: 2821 SAMSRALPSEDEEGQDDKDFYLRGAVGL-----------------------SGDHSALES 2857
SAMSRALPSEDEEGQDDKDFYLRGAVGL SGDHSALES
Sbjct: 8226 SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 8285
Query: 2858 QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 2917
QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK
Sbjct: 8286 QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 8345
Query: 2918 LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW 2977
LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW
Sbjct: 8346 LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW 8405
Query: 2978 AWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 3037
AWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD
Sbjct: 8406 AWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 8465
Query: 3038 SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 3097
SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK
Sbjct: 8466 SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 8525
Query: 3098 NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKE 3157
NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKE
Sbjct: 8526 NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKE 8585
Query: 3158 KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTP 3217
KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTP
Sbjct: 8586 KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTP 8645
Query: 3218 NRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQL 3277
NRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQL
Sbjct: 8646 NRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQL 8705
Query: 3278 LLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL 3321
LLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL
Sbjct: 8706 LLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL 8749
Score = 181 bits (460), Expect = 8e-45
Identities = 473/2685 (17%), Positives = 1039/2685 (38%), Gaps = 344/2685 (12%)
Query: 627 KATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEA 686
K +L+ +S KE + +++D +N L E +Q L +H++ A +D
Sbjct: 1249 KNSLEELISGSKEVQEQAEKILDTEN-LFEAQQ-------LLLHHQQKTKRISAKKRDVQ 1300
Query: 687 EQLAG--------------KLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQ 732
+Q+A +LR+L+ +L L+R+ ++ +Q T ++ E + T
Sbjct: 1301 QQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFE-----TN 1355
Query: 733 SPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETS 792
V +L Q T + +R S + L EL + K + R E I +Q A
Sbjct: 1356 KETVVRYLFQ--TGSSHERFLSFSSLESLSSELEQTKEF----SKRTESIAVQ--AENLV 1407
Query: 793 GDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSR 852
+A E P + ++ + S ++Q+ K L++ LE+
Sbjct: 1408 KEASEIPLGPQNKQLLQQQAKSIKEQV---------------KKLEDTLEE--------- 1443
Query: 853 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQK---LYD 909
D+ T + V + D FE +S +++ LE +
Sbjct: 1444 -------------DIKTMEM--VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDM 1488
Query: 910 GVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFP 969
+S + ++E +L ++++ E E F Q + + + ++ + + +
Sbjct: 1489 QISQIKVTIQEIESKL---SSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEEL-- 1543
Query: 970 ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQ-ILNFQNDLKV--LFTSLAD 1026
R+ + G +LG LS Q+ + ++QQ + F++ L V S A
Sbjct: 1544 -----REHAQCLEGTILGHLSQ-----QQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1593
Query: 1027 NKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK 1086
Y +LQ+ ++ +A++ + F A ++ R +QE +
Sbjct: 1594 ETYKVLQEHMDL--------CQALESLSSAITAFSASARKVVNRDS-------CVQEAAA 1638
Query: 1087 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 1146
LQ Y++++ R++ L L + E+ L LE G+ K + + I + + +
Sbjct: 1639 LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVK 1698
Query: 1147 IQQLLDKHKEYFQGLESHMILTETLFRKIIS-----FAVQ-----KETQFHTELMAQASA 1196
++ L + Q L++ ++ + + K++ F+V K + H E + +
Sbjct: 1699 VEGEL----QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWR 1754
Query: 1197 VLKRA-HKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLI----- 1250
L + +KR L+ ++ DE S +++ S + + + + ++
Sbjct: 1755 DLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHK 1814
Query: 1251 DRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKE 1310
D + K L Q L ++ G+ DL + +C+ + S+
Sbjct: 1815 DHAAEVESKKGELQSLQGHLAKLGSLGR-------AEDLHLLQGKAEDCF-QLFEEASQV 1866
Query: 1311 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 1370
+ R + L H + A L L+ + +E + E +++ LN L+ +
Sbjct: 1867 VERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMN---KNESDLIEKDLNDALQNA 1923
Query: 1371 KEVDAQSSLKSSVLSTGNQLLRLKKVDTAT-LRSELSRIDSQWTDLLTNIPAVQEKLHQL 1429
K +++ + +LS L++ + T R+ ++ + + + Q + L
Sbjct: 1924 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADAL 1983
Query: 1430 QMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQL 1489
+ K + E++ I +E + D++ +K +A+ + L+ + + ++N +
Sbjct: 1984 AVLKKAFQDQKEELLKSIEDIEE--RTDKERLKEPTR-QALQQRLRVFNQLEDELNSHEH 2040
Query: 1490 TVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWS 1549
+ ++ QI+ +DV + + ++ + +W + L+ E GL++
Sbjct: 2041 ELCWLKDKAKQIAQKDV----AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMR 2096
Query: 1550 EYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG 1609
EY+N + E + + I DQ ++ A + ++ + K+K+++ G
Sbjct: 2097 EYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKG 2156
Query: 1610 LALIQNKKEDVSS---IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 1666
L+ K+ SS +V + + W ++ + + L+ L W D+I
Sbjct: 2157 KHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEI 2216
Query: 1667 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK--E 1724
+ S V +N+ NL + L +E + + N+ L+ E
Sbjct: 2217 EGW----------------SNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEE 2260
Query: 1725 CHPPVTETLTNTLKEVNMRWNN------LLEEIAEQLQSSKALLQLWQ-RYKDYSKQCAS 1777
H V N LKE+ + ++ ++L+ +K + ++ + KD++ Q
Sbjct: 2261 LHSKV-----NDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQ 2315
Query: 1778 TVQQQEDRTNELLKAATN-KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 1836
+ D T K + + A +E ++ D+ K L + + ++ E L +
Sbjct: 2316 VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCR 2375
Query: 1837 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 1896
+ ++ ++ L + A+ Q K Q SLQ + + F++S++ + W + A+
Sbjct: 2376 KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKH--FSESMQEFQEWFLGAK 2433
Query: 1897 EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLN-DKEIKRMQ 1955
+ + + D ++ ++ +L+ + S LD + + G L + K+I
Sbjct: 2434 AAAK-ESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIV--- 2489
Query: 1956 NLNRHWSLISSQTTERFSKLQSFL---LQHQTFLEKCETWMEFLVQTEQKLAV------- 2005
S I Q T+ + Q+FL L+ + L+ C + + +KL +
Sbjct: 2490 ------SSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEE 2543
Query: 2006 -----EISGNYQHLLEQQR-AH--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEF 2057
+ + QH+ E++ H E+F E+ + ++ L + GQ L E+G + E
Sbjct: 2544 RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQ-EG 2602
Query: 2058 NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV 2117
L LL++ Q ++R +++ +++ + E + + W+ + L
Sbjct: 2603 RLCSQLLTSH-QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ----DRLACA 2657
Query: 2118 PIPLQQARTLFDEV-QFKEKVFLRQQGSYILTVEAGK--QLLLSADSGAEAALQAELAEI 2174
L TL + Q ++ + ++ +G L + GK Q L S++ + +Q +L +
Sbjct: 2658 ESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETL 2717
Query: 2175 QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAE 2234
+E W + L ++ W + + + + +K+ L L +
Sbjct: 2718 KEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQ-PGLKEK 2776
Query: 2235 QMRCKELENAVGSWTDDLTQLS-LLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
+ L++ + D L L+ + Y +D S + E L+ Q+ ++
Sbjct: 2777 FVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAK 2836
Query: 2294 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 2353
+ +++ E + + ++ + E +WL + ++ + D+ + + K +E+ +
Sbjct: 2837 EKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDS 2896
Query: 2354 QENKIQLQQMGERLA-KASHESKASEIEY---KLGKVNDRWQH-----------LLDLIA 2398
+E E LA + + AS E ++ + W+ L +L++
Sbjct: 2897 REIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVS 2956
Query: 2399 ARVKKLKETLVAVQQLDKNMSS----LRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQ 2454
+E V QL++ + L+TW + ++ EEI ++ Q
Sbjct: 2957 QMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLT------LLEGKNTDEEIVECWHKGQ 3010
Query: 2455 ELQRDIEK---HSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMS 2511
E+ ++K + + S LN + C + + L + + +C +
Sbjct: 3011 EILDALQKAEPRTEDLKSQLN---------ELCRFSRDLSTYSGKVSGLIKEYNCLCLQA 3061
Query: 2512 MERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQR 2571
+ E+ L Q+F + F+ WL +++ T A + L+K + F
Sbjct: 3062 SKGCQNKEQI--LQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLS 3119
Query: 2572 QVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFI 2631
+ +L ++ + L+ + A ++ V + W N + L++
Sbjct: 3120 ESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLK 3179
Query: 2632 GQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ---QEISLNHNKIE 2688
Q ++FE + + I WL++ + ++ + D+ AK ++ + Q +EI ++
Sbjct: 3180 IQMKDFEVSAEPIQDWLSKTE-KMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLN 3238
Query: 2689 QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 2748
++ + +QL E + + +L + + +L R+ ++ L
Sbjct: 3239 RLKEKAQQLWEGQAASKS--FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3296
Query: 2749 RELE--LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIP 2806
+EL+ + D+ + D + H S S+L + + L L+ E + +S+
Sbjct: 3297 KELQDWMTDAIHMLDSYCHPTSDKSVLDSR-TLKLEALLSVKQEKEIQMKMIVTRGESV- 3354
Query: 2807 LEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY-------LRGAVGLSGDHS---ALE 2856
L++ +P+ ++ Q KD + +R L G S + +
Sbjct: 3355 ------------LQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQ 3402
Query: 2857 SQIRQLGKALDDSRFQIQQTENI---IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKR 2913
+RQ +D + ++E +R KT + G KLL E S S+
Sbjct: 3403 DGVRQFSGWMDSMEANLNESERQHAELRDKT--------TMLGKAKLLNEEVLSYSSL-- 3452
Query: 2914 LEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDL 2973
L+ E G + T+ + + +R+ +Q +A + ++ ++ Q++ DL
Sbjct: 3453 ----LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDL 3508
Query: 2974 NSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF 3033
+ WLG +E+L+Q LE D T E ++ L+ELQ +A++ S+ +
Sbjct: 3509 KAFEVWLGQEQEKLDQYSVLE--GDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDV 3566
Query: 3034 TQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENI 3093
+ ++ +DR + SL ++W+ F+ + + L LM +
Sbjct: 3567 IPSGIPQA---EDRALE---------SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKF 3614
Query: 3094 DRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCL 3153
+ +D L + H+++ + E+ E R + D S VN+ C
Sbjct: 3615 QQ-------VDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDES---HVNSR-MGCQ 3663
Query: 3154 EAKEKVHVIGNRLKLLLKEVSRHIKEL-EKLLDVSSSQQDLSSWS 3197
+ + +R + LL +V IK L E++ + S+ LSS+S
Sbjct: 3664 ATQ-----LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYS 3703
Score = 179 bits (453), Expect = 5e-44
Identities = 583/3369 (17%), Positives = 1254/3369 (37%), Gaps = 426/3369 (12%)
Query: 7 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 66
++ + + G+ L ++ LTE+ +EN K + L + L +L
Sbjct: 1177 IRNGVTKRGETLSWLKSRLKVLTEV------SSENEAQKQGDELAKLSSSFKALVTLLSE 1230
Query: 67 IEK-----AKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
+EK + + I NS +L + SKE+ + E + + +
Sbjct: 1231 VEKMLSNFGDCVQYKEIVKNSLEEL----------ISGSKEVQEQAEKILDTENLFEAQQ 1280
Query: 122 CTEKMSQQVAELGRETEELRQMIKIRLQN---LQDAA-KDMKKFEAELKKLQAALEQA-- 175
Q+ + + +++Q I Q L D ++++K E+ L L+ + E+
Sbjct: 1281 LLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQER 1340
Query: 176 --QATLTSPE--------VGRLSLKEQLSHRQHL-LSEMESLKPK--------------- 209
Q TL E V R + SH + L S +ESL +
Sbjct: 1341 RIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIA 1400
Query: 210 VQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 269
VQA L + A IP L A ++E+ +L+ T + M+ +++ +
Sbjct: 1401 VQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGS 1460
Query: 270 EMKHLQQLIEGAHREIEDKPVATS----NIQELQAQISRHEELAQKIKGYQEQIASLNSK 325
+ L I +E+ ++S I +++ I E I G +E+ S
Sbjct: 1461 NFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSF--- 1517
Query: 326 CKMLTMKAKHATMLLTVTEV----EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLL 381
+ A + +T++ E L E + L+G +L H S +
Sbjct: 1518 -AQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTIL----GHLSQQQKFEENLRKIQ 1572
Query: 382 SPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPS 441
V+E + +I S T + + + QAL + +A S
Sbjct: 1573 QSVSEFEDKLAVPIKICSS--------ATETYKVLQEHMDLCQALES----LSSAITAFS 1620
Query: 442 TSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIST 501
SA + A A LQ+ +E + E+Q L L Q+ + L S T
Sbjct: 1621 ASARKVVNRDSCVQEAAA----LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLT 1676
Query: 502 KMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADP 561
+E E K S SPE ++ + ++ L +L +L E+VS
Sbjct: 1677 WLERGEAKAS-------SPEMDISADRVKVEGEL-------QLIQALQNEVVS------- 1715
Query: 562 AEQLALQSTLTVLAERMSTIRMKASGKRQLLE-EKLNDQLEE-----QRQEQALQRYRCE 615
Q + S L L E + ++ K K L E+L+++ + ++ LQ E
Sbjct: 1716 --QASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAE 1773
Query: 616 ADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL 675
+ D LLS + LS ++ SE+S+ + +
Sbjct: 1774 HQQFDELLLSFSVWIKLFLS------------------------ELQTTSEISIMDHQVA 1809
Query: 676 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSP 734
L E E G+L+ L+G L +L + L++ QG A++ +
Sbjct: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQ----------- 1858
Query: 735 GVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGD 794
L + + ++RQ +L E Q A +LR + E +S + D
Sbjct: 1859 -----LFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEAT---NSMNKNESD 1910
Query: 795 AGEKP--DVLSQELGMEGEKSSAED-----QMRMKWESLHQEFSTKQKLLQNVLEQEQEQ 847
EK D L +E S + Q +K S Q S + Q E E+ Q
Sbjct: 1911 LIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQ 1970
Query: 848 VLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEE-VSSQSGGAKRQSIHLEQK 906
L + + K Q + + S+ D + +E + + A +Q + + +
Sbjct: 1971 NLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2030
Query: 907 LYDGVSATS---TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEE------- 956
L D +++ WL D +++ E + + E+ D K + E
Sbjct: 2031 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCG 2090
Query: 957 ----MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN 1012
M + +NL S V+E+ ++ R ++ D + E + +N
Sbjct: 2091 LIDLMREYQNLKSAV-------SKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMN 2143
Query: 1013 FQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGD 1072
++ FTS + L+K+ + V +E+ + E +L+ D
Sbjct: 2144 YKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSE------KLEENMD 2197
Query: 1073 KLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEK 1132
+L+V S+ + DE+ + + +N++ + RA + L + + K
Sbjct: 2198 RLRV---SLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNK 2254
Query: 1133 MAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMA 1192
EE+ ++ KE + LE+ L + I + ++ + E+
Sbjct: 2255 AL--------RLEELHSKVNDLKELTKNLETPPDL------QFIEADLMQKLEHAKEITE 2300
Query: 1193 QASAVLKRAHKRGVELEYILE---TWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRL 1249
A LK + ++E + TW E+ Q E E+ + +E + +
Sbjct: 2301 VAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQ 2360
Query: 1250 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSK 1309
+ + ++L S +Y + L G+ + I + SQL + L
Sbjct: 2361 SNISSTQENLNSLCRKYHSAELESL--GRAMTGLIKKHEAVSQLCSKTQASLQ------- 2411
Query: 1310 ELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEF 1369
E++ KH++ E + ++A T S + +L +++ L++ +
Sbjct: 2412 -----ESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDG 2466
Query: 1370 SKEVDAQSSLKSSVLSTGNQLL-RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 1428
++DA V G L L K ++++ ++++ + ++ L ++ L
Sbjct: 2467 QSKLDA-------VTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQD 2519
Query: 1429 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQ 1488
+ ++ WI ME + N +N +G H +K + K+++ +
Sbjct: 2520 CASELGSFEDQHRKLNLWIHEME-----ERFNTEN-LGESKQHIPEKKNEVHKVEMFLGE 2573
Query: 1489 LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESW 1548
L + L Q + + + S Q L + EK++ + L+
Sbjct: 2574 LLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633
Query: 1549 SEYENNVQCLKTWFETQEKRLK-QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 1607
E +Q + W + + RL + +G + +++ L QD+ + E ++
Sbjct: 2634 EALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIG 2693
Query: 1608 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 1667
G +++ ++ ++ + L L + WA++ + L+SV+ QW+ + +++
Sbjct: 2694 KGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLE 2753
Query: 1668 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 1727
++ + L+ V +D+LQ++ + E R+L + + + +L ++
Sbjct: 2754 QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTED 2813
Query: 1728 PVTETLTNTLKE-VNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 1786
E+ +T +E + ++N+++ E+++ + +++ Y D + + ++
Sbjct: 2814 ---ESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
Query: 1787 NELLKAATNKDIADDEVATW--IQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 1844
+ D++ D AT + +L+ L + L ++KQ AS
Sbjct: 2871 HRW------SDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCE 2924
Query: 1845 AIQSDQLSLS-----------QHLCALEQ-----ALCKQQTSLQAGVLDY---------E 1879
+ ++ +L Q LE AL +Q+ S Q L+ +
Sbjct: 2925 LMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLK 2984
Query: 1880 TFAKSLEALEAWIVEAEEILQ----GQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLD 1935
T+A+ L LE + EEI++ GQ+ + L + R E+LK Q+ + + DL
Sbjct: 2985 TWAQQLTLLEGKNTD-EEIVECWHKGQEILDA--LQKAEPRTEDLKSQLNELCRFSRDLS 3041
Query: 1936 RLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEF 1995
+ ++ L + ++ + Q ++ + L Q F + + ++
Sbjct: 3042 TYSG-------------KVSGLIKEYNCLCLQASKGCQNKEQIL--QQRFRKAFRDFQQW 3086
Query: 1996 LVQTEQKLA--VEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDD 2053
LV + A +I N + + + F +E + Q L+ ++ G+ L +
Sbjct: 3087 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEK 3146
Query: 2054 RDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL------VEVS 2107
K+T W+ Q+ +++ Q + + AE ++ WL V S
Sbjct: 3147 AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHES 3206
Query: 2108 YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAAL 2167
+ L + Q+ +++ +E+ E R + E +QL A +
Sbjct: 3207 SNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLK-------EKAQQLW--EGQAASKSF 3257
Query: 2168 QAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDH 2227
+ ++++ ++ + S +E+ +L ++ + + GI + L+ T + S
Sbjct: 3258 RHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKE-LQDWMTDAIHMLDSYCHP 3316
Query: 2228 HEELHAEQMRCKELENAVGSWTDDLTQLSLLK---DTLSAYISADDISILNERVELLQRQ 2284
+ R +LE + + Q+ ++ +++ S + I + ++++ ++
Sbjct: 3317 TSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDM 3376
Query: 2285 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKL-- 2342
W L + Q+ L++W + + ++ W+ ME+ ++++ E +L
Sbjct: 3377 WASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNES-----ERQHAELRD 3431
Query: 2343 KKDYQEEIAIAQENKIQLQQMGERL-AKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 2401
K + + E + + E + K + ++ + +L + +R++ + + V
Sbjct: 3432 KTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAV 3491
Query: 2402 KKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 2461
K ++ + Q+ +++ + WL + +L + V + ++ + L + QELQ
Sbjct: 3492 TKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEG-DAHTHETTLRDLQELQVHCA 3550
Query: 2462 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEET 2521
+ + SVL+ E ++ A D +S++Q W+ E R +
Sbjct: 3551 EGQALLNSVLHTREDVIPSGIPQAEDRALESLRQD-------WQAYQHRLSETRTQFNNV 3603
Query: 2522 WRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLE 2581
+ + + ++WLK++E K+ ++ A++ +V E
Sbjct: 3604 VNKLRLMEQKFQQVDEWLKTAEE---------------KKWHEEVTAYRDEVEE------ 3642
Query: 2582 LINKQYRRLARENRTDS--ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 2639
+ + + + E+ +S C Q+ R+ L +V ++ L+ I EE E+
Sbjct: 3643 -VGARAQEILDESHVNSRMGCQATQLT----SRYQALLLQVLEQIKFLEEEIQSLEESES 3697
Query: 2640 ARDSILVWLTEMDLQLTN----IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGE 2695
+ S W N I+ + K+K L+ +++ H+ ++ +GE
Sbjct: 3698 SLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGE 3757
Query: 2696 QLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELED 2755
+ ++ E +A + +E+ + +E+ V + H L + E + L
Sbjct: 3758 RAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWI 3817
Query: 2756 SAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 2815
+ LH + L + + SL Q + S + LE D L
Sbjct: 3818 AEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTL 3877
Query: 2816 SRDLESAMS---------RALPSEDEEGQDDK--DFYLRG--AVGLSGDH--SALESQIR 2860
++ S +A+ E+ G +D+ + ++G +G DH + L+ +
Sbjct: 3878 KDKIDQLQSDYQDLCSIGKAM-MEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVH 3936
Query: 2861 QLGKALDDSRFQIQQT-------------ENIIRSKT---------PTGPELDTSYKGYM 2898
+ DS I T +++ R T P+L+ S + +
Sbjct: 3937 AHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPL 3996
Query: 2899 KLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT-AGVIDRWELLQAQALSKEL 2957
E + + L+ + + + L +L + +T A I + E Q + ++L
Sbjct: 3997 SR-AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QTIEQKL 4051
Query: 2958 RMKQNL-QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 3016
QNL Q W++ + +W +L D +++L+ ++R ++ + + ++K+ K +
Sbjct: 4052 VQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKL 4111
Query: 3017 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 3076
++A S+N + + KE ++ +N +W +C ++ L +
Sbjct: 4112 QSKQA---SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRT 4168
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
+ +H+ + + + LE + + + DAE H + L ++ L E + + L
Sbjct: 4169 RDYHDCMNVVEVFLEKFTTEWDNL----ARSDAESTAVHLEALKKLALALQERKYAIEDL 4224
Query: 3137 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRL----KLLLKEVSRHIKELEKLLDVSSSQQD 3192
+D +++ + D KE+ + R L+ +++ + LE+L V S Q+
Sbjct: 4225 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQE 4284
Query: 3193 LSSWSSADE 3201
L W+ +
Sbjct: 4285 LMEWAEEQQ 4293
Score = 171 bits (434), Expect = 8e-42
Identities = 597/3333 (17%), Positives = 1269/3333 (38%), Gaps = 437/3333 (13%)
Query: 5 AAVQKFLEQNGQLGK----PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
A+V +E+ +L K P K+I L + RQ+ N + + +Y++ +
Sbjct: 4116 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
Query: 61 ELILKWIEKAKVLAHGTIAW-NSASQLREQYILH-------QTLLEESKEIDSELEAMTE 112
++ ++EK T W N A E +H L+E K +L+ +
Sbjct: 4176 NVVEVFLEKF------TTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ 4229
Query: 113 KLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAAL 172
K+ ++ E + +Q + L + +L +IK ++Q +++ ++ ++L
Sbjct: 4230 KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWA 4289
Query: 173 EQAQATLTS-------PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPED 225
E+ Q + P++ + L + L+ L ++ LK ++ + L + E
Sbjct: 4290 EEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNER 4349
Query: 226 VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI 285
V L A Q + L Q+ + A+ + Q+ + I+ R+I
Sbjct: 4350 QVIQKALSDA----QSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI 4405
Query: 286 EDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 345
+ ++ Q+ + +K YQ ++ L A+ ++ VTE
Sbjct: 4406 MFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL---------WAQGRELMKEVTEQ 4456
Query: 346 EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT-----EESGEEGTNSEISSP 400
E ++ G+L S + SV+ + R L + +E ++ + +
Sbjct: 4457 E-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD 4511
Query: 401 PACRSPSPVANTDASVNQDIAYYQALSAE---------RLQTDAAKIHPSTSASQEFYEP 451
+ N + ++ +A YQ + + LQ I PS + Y
Sbjct: 4512 IVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY-- 4569
Query: 452 GLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD----SLQSISTKMEAIE 507
+ KL L R + + + +K + EA+ +++Y + QS+S ++EA
Sbjct: 4570 -----LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS-ELEAQF 4623
Query: 508 LKLSESPEPGRSPESQMAEH--QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 565
L++S+ P E+ + +A++DE+ L + ++EL E S P + L
Sbjct: 4624 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQK-KEGFRSTGQPWQPDKML 4682
Query: 566 ALQSTLTVL----AERMSTIRMKASGKR------QLLEEKLNDQLEEQRQ--------EQ 607
L + L +R+S + S + Q LE +L EEQ + E+
Sbjct: 4683 HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEE 4742
Query: 608 ALQRYRCEADEL-DSWLLSTKATLDTA-LSPPKEPMDMEAQLMDCQNMLVEIEQKVVALS 665
L+ Y A L DS ++ + T+ L+P +P+ E Q+ E++ A+
Sbjct: 4743 KLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIG 4802
Query: 666 ELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSL-----LELQRALHDKQLNMQGTAQE 720
E E+ +++ + E + LRR+K L L+L +++ QE
Sbjct: 4803 ETVTECESRMVQ-SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQE 4861
Query: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE----QKSLLRSVA 776
+ +S + + S +E +A+ + + SL + EL+ ++ E +++ L +
Sbjct: 4862 EVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIY 4921
Query: 777 SRGEEILIQHSAA--------ETSGDAGEKPDVLSQELGMEG--EKSSAEDQMRMKWESL 826
S+ + AA E AG DV S E ++ E S EDQ E L
Sbjct: 4922 SQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEEL 4981
Query: 827 HQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAF 886
H +T L++ +++ EQ + S R ++D A LL +
Sbjct: 4982 HSLVATLDPLIKPTGKEDLEQKVASLELR---------SQRMSRDSGAQVDLLQRCTAQW 5032
Query: 887 EEVSSQSGGAKRQSIHL----EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFN 942
+ A+ + I L E+KL + ++ + EE+L AL+ F+
Sbjct: 5033 HDYQK----AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNS---FH 5085
Query: 943 QEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQ 1002
++I+A ++E + +++K N S+A + ++ + R + L +V +
Sbjct: 5086 EKIVA--LEEKASQLEKTGNDASKA---------TLSRSMTTVWQRWTRLRAVAQDQEKI 5134
Query: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062
+++ + + F N +K T + D LQ A + E + L+ D
Sbjct: 5135 LEDAVDEWTGFNNKVKKA-TEMIDQ----LQDKLPGSSAEKASKAELLTL----LEYHDT 5185
Query: 1063 GIIELKRRGDKLQV-------------------EQPSMQELSKLQDMYDELMMIIGSRRS 1103
++EL+++ L + E P MQE++ +QD + + +
Sbjct: 5186 FVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5245
Query: 1104 GLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES 1163
+ Q L + E + + ++ +E + I + EE+Q LL + + Q +E
Sbjct: 5246 LVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK 5305
Query: 1164 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ 1223
+ E K + T +EL Q + V R + I E Q
Sbjct: 5306 ---MAEEQKEKYLGL----YTILPSELSLQLAEVALDLKIRDQIQDKIKEV-EQSKATSQ 5357
Query: 1224 ELSRQLEVVESSIPSV-GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
ELSRQ++ + + ++ ++ D ++ T + L L+ KL + LD + +
Sbjct: 5358 ELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLME-LDAAVQKFL 5416
Query: 1283 SIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAK 1339
+ L ++ +L E + L +L H Y ++ W++ AK
Sbjct: 5417 EQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK 5476
Query: 1340 DRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV--D 1397
L T + Q E H LE SKE+D++ + L + +K+
Sbjct: 5477 -VLAHGTIAWNSASQLREQYILH-QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ 5534
Query: 1398 TATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKD 1457
A L E + L N+ + + + + + + A+ + + ++ E
Sbjct: 5535 VAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPE----VG 5590
Query: 1458 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 1517
++K + ++ L + + K + QL QS L+I V S
Sbjct: 5591 RLSLKEQLSHR--QHLLSEMESLKPKVQAVQLC-----QSALRIPEDVVAS-----LPLC 5638
Query: 1518 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH-RIG 1576
+ + LQ ++ +++ + + +YE ++ L+ E + ++ +
Sbjct: 5639 HAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS 5698
Query: 1577 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 1636
+ +Q + ++L IK ++++ + L K + ++ + L +
Sbjct: 5699 NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE 5758
Query: 1637 NLD---------------HMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR 1681
+LD G+ LL V ++ S + +I+S A S S
Sbjct: 5759 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE-SGEEGTNSEISS--PPACRSPSPVA 5815
Query: 1682 LLTGSL--EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKE 1739
S+ + Q + + LQ D K S T+ + P + + T L +
Sbjct: 5816 NTDASVNQDIAYYQALSAERLQTDAAKIHPS-------TSASQEFYEPGLEPSATAKLGD 5868
Query: 1740 VNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIA 1799
+ W L I+E+ ++ L+ Q+Y+D + ++ ++ E + +E + + +
Sbjct: 5869 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5928
Query: 1800 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859
E + + L + ++ SL EL + + D + A+QS L++ +
Sbjct: 5929 MAEHQALMDEILMLQDEINELQSSL--AEELVSE-SCEADPAEQLALQSTLTVLAERMST 5985
Query: 1860 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEI---LQGQDPSHSSDLSTIQER 1916
+ ++ L+ + D + +AL+ + EA+E+ L + + LS +E
Sbjct: 5986 IRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP 6045
Query: 1917 MEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 1976
M +++ Q++ +M ++++ L ++++ + + H + Q + +L+
Sbjct: 6046 M-DMEAQLMDCQNMLVEIEQKVVALSELSVHNENL--LLEGKAHTKDEAEQLAGKLRRLK 6102
Query: 1977 SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI----SGNYQHLLEQQRA------------ 2020
LL+ Q L + M+ Q +++ V++ S Q L Q R
Sbjct: 6103 GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ 6162
Query: 2021 HELFQAEMFSRQQILHSIIIDGQR-LLEQGQVDDRDEFNLKLTLLSNQ------------ 2067
+ + E+ ++ +L S+ G+ L++ + + K +LS +
Sbjct: 6163 QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED 6222
Query: 2068 -----WQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ 2122
W+ + + ++ ++ + + Q Q + R +S +P+ G VP +
Sbjct: 6223 QMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRL----LSGVPLY-KGDVPTQDK 6277
Query: 2123 QART-LFDEV-QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKS 2180
A T L D + Q E+V + G+ ++ ++L +A L +++E+
Sbjct: 6278 SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY-----DGVSATSTWLDDVEERLFV 6332
Query: 2181 ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE 2240
A+ L E+ + F + E K I + E++ K SQ+ P++ +
Sbjct: 6333 ATALLPEETETCLF---NQEILAKDIKEMSEEMDKNKNLFSQAFPENGD----------- 6378
Query: 2241 LENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 2300
+++DTL + R+ LL + CHQ+ R QQI
Sbjct: 6379 -------------NRDVIEDTLGCLLG---------RLSLLDSVVNQRCHQMKERLQQIL 6416
Query: 2301 ERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQL 2360
N+ L + + ++ N I+++++ ++ E+I Q+ + L
Sbjct: 6417 NFQND--------------LKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 6462
Query: 2361 QQMGERLAKASHESKASEIE----YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK 2416
++ + + ++E +L K+ D + L+ +I +R L + L Q ++
Sbjct: 6463 KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER 6522
Query: 2417 NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
+ L L + ++A + EEIQ+ L++ +E + +E H + L E
Sbjct: 6523 ALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH-------MILTET 6575
Query: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
L + A E Q L + + + +R +++E W LD E
Sbjct: 6576 LFRKIISFAVQKE----TQFHTELMAQASAVLKRAHKRGVELEYILETW-SHLD-----E 6625
Query: 2537 DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENR- 2595
D + S + SS + V + E + + H + E K Y+ L R
Sbjct: 6626 DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL 6685
Query: 2596 --TDSACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREE-------FETARD 2642
+ S L+ +++ + W + +++ L R LKH+ + E ++A+D
Sbjct: 6686 LISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKD 6745
Query: 2643 SILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 2702
+ W + +E V+ + F +E+ + +++ G QL+ + +
Sbjct: 6746 RLEFWTQQSVTVPQELEM-----VRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL-RLK 6799
Query: 2703 PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSD- 2761
+D A + EL + ++ + +KL +L + +L A+S+
Sbjct: 6800 KVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMD-----------KLPSRHAISEV 6848
Query: 2762 LHWHDRSADSLLSPQPS--SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL---S 2816
+ W + + + + +++ + G + + +++ + L S
Sbjct: 6849 MSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISS 6908
Query: 2817 RDLESAMSRALPSEDEEGQDDKDF-YLRGAV--------GLSGDHSALESQIRQLGKALD 2867
+D+ES S ++ G +K + L+G V GL S E+ ++ L +
Sbjct: 6909 QDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFE 6968
Query: 2868 DSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPG 2927
+++Q I L +C D +K E ++++ E++ G
Sbjct: 6969 TQEKRLKQQHRI------------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--G 7014
Query: 2928 FVNLHSTETQTAGVI--------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 2979
+ + + + ++ W L ++ +K L +W + I ++
Sbjct: 7015 LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSY 7074
Query: 2980 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADS 3038
L + L + + L+ ++ +++Q+ L+ LQ ++ ++ + ++ + +
Sbjct: 7075 LMEARYSLSRFRL--LTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 7132
Query: 3039 KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDR 3095
+ L + L ++N RW+ +LLEE LQ AL+Q Q + + S ++ +
Sbjct: 7133 PVTETLTNTLKEVNMRWN---NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7189
Query: 3096 RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLE 3128
R NE++ +N D I D +Q ++LL+
Sbjct: 7190 RTNELLKAATNKD--IADDEVATWIQDCNDLLK 7220
Score = 166 bits (421), Expect = 3e-40
Identities = 574/3251 (17%), Positives = 1230/3251 (37%), Gaps = 493/3251 (15%)
Query: 28 LTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLR 87
L + ++ +R+A+ R + L +H + + L L W+E+ + A SA +++
Sbjct: 1639 LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVK 1698
Query: 88 EQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCT------EKMSQQVAELGRETEELR 141
+ L Q + E+ S+ ++ LQ S++ + M + +L +L
Sbjct: 1699 VEGEL-QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP 1757
Query: 142 QMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATL-TSPEVGRLSLKEQLSHRQHLL 200
Q+I R+ LQ + ++F+ L ++ + L T+ E+ + + L+ +
Sbjct: 1758 QIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHA 1817
Query: 201 SEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAA 260
+E+ES K ++Q++Q + L +L E+ LQ A + + A
Sbjct: 1818 AEVESKKGELQSLQGHLAKL--------------GSLGRAEDLHLLQGKAEDCFQLFEEA 1863
Query: 261 VVQYEQYEQEMKHLQQLIE------GAHREIEDKPVATSNIQELQAQISRHE--ELAQKI 312
E+ + + HL + ++ G R++ AT+++ + ++ + + + Q
Sbjct: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923
Query: 313 KGYQEQIASLN---SKCKM---LTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH 366
K + SL+ SK + + + + T ++ G E ++L G A
Sbjct: 1924 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADAL 1983
Query: 367 PSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQAL 426
+ + LL + E EE T+ E P T ++ Q + + L
Sbjct: 1984 AVLKKAFQDQKEELLKSI--EDIEERTDKERLKEP----------TRQALQQRLRVFNQL 2031
Query: 427 SAERLQTDAAKIHPSTSASQEFYEP-GLEPSATAKLGDLQRSWETLKNVISEKQRTLYEA 485
E + A Q + P ++ L+ +W+ K +I E Q
Sbjct: 2032 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2091
Query: 486 LERQQKYQDSLQSISTKME--AIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINE 543
++ ++YQ+ ++S +E + + + + + ++H+ +++ Q +++
Sbjct: 2092 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2151
Query: 544 LQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQ 603
+S + L+SE + ++ +++ + ++ + EKL + ++
Sbjct: 2152 F-TSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDV-----------SEKLEENMDRL 2199
Query: 604 RQEQAL-QRYRCEADELDSW-------LLSTKATLDTALSPPKEPMDMEAQLMDCQNMLV 655
R ++ DE++ W + + LD L + + E+++ + L
Sbjct: 2200 RVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLE 2259
Query: 656 EIEQKVVALSELSVHNENL---------LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRA 706
E+ KV L EL+ + E L++ H K+ E G L
Sbjct: 2260 ELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTL------------- 2306
Query: 707 LHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELA 766
K Q T EK +D+ T+ V+E L T + +L++ K++++EL
Sbjct: 2307 ---KDFTAQSTQVEKFINDITTWFTK---VEESLMNCAQNETCE---ALKKVKDIQKELQ 2357
Query: 767 EQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESL 826
Q+S + S + ++ +AE + LG A + K E++
Sbjct: 2358 SQQSNISSTQENLNSLCRKYHSAEL------------ESLG------RAMTGLIKKHEAV 2399
Query: 827 HQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYK-GDVPTQDKSAVTSLLDGLNQA 885
Q S Q LQ LE+ + + L K T D + + L L
Sbjct: 2400 SQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNI 2459
Query: 886 FEEVSSQSGGAKRQSIHLE-QKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQE 944
+ VS G +K ++ E Q LY +S + ++E++ A + CL +++
Sbjct: 2460 LDSVS--DGQSKLDAVTQEGQTLYAHLS--KQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2515
Query: 945 ILAKDIKEMS--EEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQ 1002
L E+ E+ + NL+ E + ++ E Q +
Sbjct: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGES----------------KQHIPE 2559
Query: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062
K + ++ F +L S L KL+ + E A Q+ + +
Sbjct: 2560 KKNEVHKVEMFLGELLAARES--------LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS 2611
Query: 1063 GIIELKRRGDKLQVEQPSMQELSKLQDMYDEL---MMIIGSRRSGLNQNLTLKSQYERAL 1119
L+ +KL+ Q ++QE L++ + + I R + L K E+ L
Sbjct: 2612 HQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRL 2671
Query: 1120 QDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFA 1179
+ D+L K G+ K+ ++ + Q L +KE + +++ + + ++ I+S +
Sbjct: 2672 SQIQDIL---LMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
Query: 1180 VQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI--- 1236
V ++ LE ++ W+ E + +L + +E V+ I
Sbjct: 2729 VHAQS----------------------TLESVISQWNDYVERKNQLEQWMESVDQKIEHP 2766
Query: 1237 --PSVGLVEENEDRLIDRITLYQHLKSSLNE---YQPKLYQVLDDGKRLLISISCSDLES 1291
P GL E + L HL+S L+E + L++++ + L +
Sbjct: 2767 LQPQPGLKE--------KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKD 2818
Query: 1292 QLNQLGECWLSNTNKMSKE-LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV 1350
+ + ++ ++KE + ++E I+K Y + WL SAK+ L W+ S
Sbjct: 2819 TAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMS- 2877
Query: 1351 TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDS 1410
SS LS +L+ +++ S LSR++S
Sbjct: 2878 ------------------------GDSSATQKKLSKIKELIDSREIGA----SRLSRVES 2909
Query: 1411 QWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAI 1470
++ N A +L +M L + W ++V Q + ++N + A+
Sbjct: 2910 LAPEVKQNTTASGCELMHTEMQALRA--------DWKQWEDSVFQ-TQSCLENLVSQMAL 2960
Query: 1471 HEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQIL 1530
E Q++ G + +Q F ++L+ +Q + TD E + +K +IL
Sbjct: 2961 SE--QEFSGQVAQL--EQALEQF--SALLKTWAQQLTLLEGKNTD-EEIVECWHKGQEIL 3013
Query: 1531 QGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD 1590
L + + E L +E + L T+ +K+ + + QAS K CQ+
Sbjct: 3014 DALQKAEPR-TEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQAS-----KGCQN 3067
Query: 1591 LEDLIKAKEKEVEKIEQNGLA---LIQNKKEDVS---SIVMSTLRELGQTWANLDHMVGQ 1644
E +++ + ++ + Q L + K D+ S V ++L+++ + + ++ GQ
Sbjct: 3068 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN--GQ 3125
Query: 1645 LKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDL 1704
K+ + + S + +K + + ++ +L + ++NL+ D
Sbjct: 3126 HKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDF 3185
Query: 1705 EKQERSLQKFGSITNQLLKECHPPV---------TETLTNTLKEVNM--RWNNLLEEIAE 1753
E +Q + S T +++ E + + L + L+E++ N L+E A+
Sbjct: 3186 EVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQ 3245
Query: 1754 QLQSSKALLQLWQ-RYKDYSKQ---CASTVQQQEDRTNELLKAATNKDIADDEVATWIQD 1809
QL +A + ++ R S Q ++ +++ R + ++ + E+ W+ D
Sbjct: 3246 QLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTD 3305
Query: 1810 CNDL--------------------LKGLGTVKD----SLFFLHELGEQLKQQVDASAASA 1845
+ L+ L +VK + + GE + Q
Sbjct: 3306 AIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT 3365
Query: 1846 IQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 1905
IQ S+ +L A + ++ L+ + + ++ + W+ E L +
Sbjct: 3366 IQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQ 3425
Query: 1906 HSS--DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSL 1963
H+ D +T+ + + L ++L +SS+ L+ + G + + +Q+L +
Sbjct: 3426 HAELRDKTTMLGKAKLLNEEVLSYSSL---LETIEVKGAGMTEHYVTQLELQDLQERYRA 3482
Query: 1964 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 2023
I + E +K + + HQ + + + +L Q ++KL Y L HE
Sbjct: 3483 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKL-----DQYSVLEGDAHTHET 3537
Query: 2024 -------FQAEMFSRQQILHSIIIDGQRLLEQG--QVDDRDEFNLKLTLLSNQWQGVIRR 2074
Q Q +L+S++ + ++ G Q +DR L L WQ R
Sbjct: 3538 TLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDR-----ALESLRQDWQAYQHR 3592
Query: 2075 AQQRR----------GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 2124
+ R +++ + +Q + + AE+ +KW EV+ + V +A
Sbjct: 3593 LSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE-KKWHEEVT----AYRDEVEEVGARA 3647
Query: 2125 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSAS-- 2182
+ + DE ++ G + + Q LL L+ E+ ++E S S
Sbjct: 3648 QEILDESHVNSRM-----GCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSY 3702
Query: 2183 -----------------------MRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK 2219
+ + ++ K L LLKD EK + + EK K
Sbjct: 3703 SDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKY 3762
Query: 2220 LSQSLPDH-HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERV 2278
L + + +E+H + KEL + V ++L K A +D L + +
Sbjct: 3763 LEEGEAERLRKEIHDHMEQLKELTSTVRK-----EHMTLEKGLHLAKEFSDKCKALTQWI 3817
Query: 2279 ELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIE-- 2336
+++E+ H + ++ E+ + + + + + ++S V + G+ L+E
Sbjct: 3818 ----AEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKS-VREKGEALLELV 3872
Query: 2337 ------EMIEKLKKDYQ----------EEIAIAQENKIQLQQMGERLAK--ASH-ESKAS 2377
+ I++L+ DYQ EEIA ++ LQ G+ L A H ++K
Sbjct: 3873 QDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 3932
Query: 2378 E-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI 2436
+ + L D + + + L+ L + + WL+ ++ +L +P
Sbjct: 3933 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL-EPS 3991
Query: 2437 VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC--DACATDAECDSIQ 2494
+ E +++ + LQ + + S+ +L + D T+ +
Sbjct: 3992 PQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL 4051
Query: 2495 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 2554
+NL + W I + E + +++ + Q +S E + +
Sbjct: 4052 VQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQN------------ 4099
Query: 2555 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWD 2614
+ + K+ +KK ++ Q V+ T +E +NK ++ + + K++ H N +W
Sbjct: 4100 MVSQVKDFVKKLQSKQASVN---TIIEKVNKLTKK-------EESPEHKEINHL-NDQWL 4148
Query: 2615 NLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK 2674
+L ++ ++ + + + + ++ + + V+L + + N+ ++ LK
Sbjct: 4149 DLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALK 4208
Query: 2675 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 2734
+ IE + Q +++IE D +++E+ L ++ + ++E K+
Sbjct: 4209 KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHL----EQRWFQLEDLIKRK 4264
Query: 2735 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLL-----SPQP--SSNL---SLS 2784
I++ + + E EL + S + W + ++ SP P + NL L+
Sbjct: 4265 IQVSVTNLE------ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4318
Query: 2785 LAQPLRSER---SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 2841
+ L +++ A L + + + L A S D GQ K Y
Sbjct: 4319 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRK--Y 4376
Query: 2842 LRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLL 2901
L A+ S+ Q A+ + QIQQ E I ++ ++ LL
Sbjct: 4377 LNKAL----------SEKTQFLMAVFQATSQIQQHERKI------------MFREHICLL 4414
Query: 2902 -GECSSSIDSVKRLEHKLKEEEESLPGF------VNLHSTETQTAGVIDRWELLQA---- 2950
+ S + + K + LK + + G + TE + + V+ + + LQ+
Sbjct: 4415 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474
Query: 2951 --QALSKELR-MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 3007
Q S L+ +++NL + F D + WL + ++ + L + + Q+
Sbjct: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWL--KQADIVTFPEINLMNESSELHTQLA 4532
Query: 3008 KLKELQKAVDHRKAIILSINLCS----PEFTQADSKESRDLQDRLSQMNGRWDRVCSLLE 3063
K + + + + ++L++ P + D L ++L+ + +++ + +L +
Sbjct: 4533 KYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY---LSEKLNALPRQFNVIVALAK 4589
Query: 3064 EWRGLLQDALM 3074
+ +Q+A++
Sbjct: 4590 DKFYKVQEAIL 4600
Score = 149 bits (375), Expect = 6e-35
Identities = 553/3140 (17%), Positives = 1188/3140 (37%), Gaps = 397/3140 (12%)
Query: 39 AENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLE 98
A+ ++ K+ + Y + + W+ AK H + S ++ + L
Sbjct: 2835 AKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELI 2894
Query: 99 ESKEID----SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMI---KIRLQNL 151
+S+EI S +E++ +++ T+ E M ++ L + ++ + + L+NL
Sbjct: 2895 DSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENL 2954
Query: 152 -QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 210
A ++F ++ +L+ ALEQ A L + +L+L E + + ++ + +
Sbjct: 2955 VSQMALSEQEFSGQVAQLEQALEQFSALLKT-WAQQLTLLEGKNTDEEIVECWHKGQEIL 3013
Query: 211 QAVQLCQSALRIPEDVVASL-PLCHAALRLQEEASRLQHTAIQ-QCNIMQAAVVQYEQYE 268
A+Q + ED+ + L LC + L + ++ + C +QA+ + +
Sbjct: 3014 DALQKAEPRT---EDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQAS----KGCQ 3066
Query: 269 QEMKHLQQLIEGAHREIE----DKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 324
+ + LQQ A R+ + + + T+ ++ IS QKI+ + + +
Sbjct: 3067 NKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQH 3126
Query: 325 KCKMLTMKAKHATMLLTVTEVEGL-------AEGTEDLDGELLPTPSAHPSVVM------ 371
K M+ K + + LLT + +G+ E ++ L SA ++ +
Sbjct: 3127 KLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE 3186
Query: 372 MTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERL 431
++A LS TE+ E +N P R + SV ++I Y+ RL
Sbjct: 3187 VSAEPIQDWLSK-TEKMVHESSNRLYDLPAKRREQQKL----QSVLEEIHCYEP-QLNRL 3240
Query: 432 QTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQK 491
+ A ++ +AS+ F ++ L + L N+ EK L + +
Sbjct: 3241 KEKAQQLWEGQAASKSFRH---------RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQ 3291
Query: 492 YQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSL--- 548
+ ++ + M L P + + + + + L E L+ + E+Q +
Sbjct: 3292 FSLGIKELQDWMTDAIHMLDSYCHP--TSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3349
Query: 549 --AEELVSESCEADPAEQLALQSTLTVLAERMST-IRMKASGKRQLLEEKLNDQLEEQRQ 605
L + S E P Q LQS + A +S IR K+ +
Sbjct: 3350 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS------------------QL 3391
Query: 606 EQALQRYRCEAD---ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVE---IEQ 659
E AL ++ D + W+ S +A L+ E A+L D ML + + +
Sbjct: 3392 EGALSKWTSYQDGVRQFSGWMDSMEANLN-------ESERQHAELRDKTTMLGKAKLLNE 3444
Query: 660 KVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ 719
+V++ S L E + ++G T+ QL +L+ L+ +Q + + +
Sbjct: 3445 EVLSYSSLL---ETIEVKGAGMTEHYVTQL--ELQDLQERYRAIQERAKEAVTKSEKLVR 3499
Query: 720 EKEESDVDLTATQSPGVQEWLAQARTTWTQ---------QRQSSLQQQKELEQELAEQKS 770
+E DL A + WL Q + Q +++L+ +EL+ AE ++
Sbjct: 3500 LHQEYQRDLKA-----FEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3554
Query: 771 LLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEF 830
LL SV E+++ G+ + A + +R W++
Sbjct: 3555 LLNSVLHTREDVI---------------------PSGIPQAEDRALESLRQDWQAYQHRL 3593
Query: 831 S----------TKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDV--------PTQDK 872
S K +L++ +Q E + + + V Y+ +V D+
Sbjct: 3594 SETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDE 3653
Query: 873 SAV--------TSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEER 924
S V T L +V Q + + LE+ +S+ S W +
Sbjct: 3654 SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEES-ESSLSSYSDWYGSTHKN 3712
Query: 925 LFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQA---------FPENGDNR 975
F A ++ +T + +++ K ++ + ++M+K +L A + E G+
Sbjct: 3713 -FKNVATKIDKVDTVMMGKKL--KTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE-A 3768
Query: 976 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 1035
+ + + + +L L S V + +++ L F + K L +A+ Q++
Sbjct: 3769 ERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAE-----YQEI 3823
Query: 1036 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 1095
+V E+P E L E A + + K + +PS++ + + + EL+
Sbjct: 3824 LHVPEEPKME-----------LYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV 3872
Query: 1096 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHK 1155
Q++TLK + ++ D DL G+ M EEI D+
Sbjct: 3873 -----------QDVTLKDKIDQLQSDYQDLCSIGKAMM-----------EEIAGFEDR-- 3908
Query: 1156 EYFQGLESHMILTETLFRKIISFAVQKETQ-FHTELMA---QASAVLKRAHKRGVELEYI 1211
L + + +TL + K Q H L SA+ A + LE+
Sbjct: 3909 -----LNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHE 3963
Query: 1212 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLY 1271
L+ + Q+ L V+ + + I ++ ++ L+ Y L
Sbjct: 3964 LQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLC 4023
Query: 1272 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 1331
+ D L + S + Q + ++L + + + + W + ++L
Sbjct: 4024 SMCD-----LSNASVKTTAKDIQQ-------TEQTIEQKLVQAQNLTQGWEEIKHLKSEL 4071
Query: 1332 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 1391
+LQ A +L+ ++ + EL + ++ ++ +F K++ ++ + ++++ N
Sbjct: 4072 WIYLQDADQQLQNMKRRHSEL--ELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVN--- 4126
Query: 1392 RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLME 1451
+L K + + E++ ++ QW DL L + + L + M+ + +
Sbjct: 4127 KLTKKEESPEHKEINHLNDQWLDLCRQ----SNNLCLQREEDLQRTRDYHDCMNVVEVFL 4182
Query: 1452 NVIQKDEDNIKNSIGYK-AIHEYLQKYKGFKIDINCKQLTV-DFVNQSVLQISSQDVESK 1509
+ DN+ S A+H L+ K + + ++ + D +Q I +++ K
Sbjct: 4183 EKFTTEWDNLARSDAESTAVH--LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDK 4240
Query: 1510 RSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRL 1569
K EQ + + W L+ L+ KIQ+ LE + ++ Q L W E Q+ +
Sbjct: 4241 ELVK----EQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNI 4296
Query: 1570 KQQHRIGDQASV-QNALKD----CQDLE-------DLIKAKEKEVEKIEQNGLALIQNKK 1617
+ + + QN L D C +LE LIK ++ + + N +IQ
Sbjct: 4297 AEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKAL 4356
Query: 1618 EDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSL 1677
D S V L +VGQ + L L + + +A + S + + +
Sbjct: 4357 SDAQSHVNC-----------LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI 4405
Query: 1678 SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTL 1737
+ + V QV ++ Q L+ + + + +L+KE + L
Sbjct: 4406 MFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKL 4465
Query: 1738 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYK-DYSKQCASTVQQQEDRTNELLKAATNK 1796
+E+ ++++L++ + +LQ + L + +K D+ K C Q E+ N
Sbjct: 4466 QELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEI-----NL 4520
Query: 1797 DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQH 1856
E+ T + ++L+ ++ L L G+ + ++ + D LS+
Sbjct: 4521 MNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN-------EVDHSYLSEK 4573
Query: 1857 LCALEQ------ALCKQQ-TSLQAGVLDYETFAKSLEALEAWI--VEAEEILQGQDPSHS 1907
L AL + AL K + +Q +L + +A +E + +EA+ + + P+
Sbjct: 4574 LNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDL 4633
Query: 1908 S--DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLIS 1965
+ + ++Q+ + ++ +L++ E G+R + +M +L + +
Sbjct: 4634 AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKE-GFRSTGQPWQPDKMLHLVTLYHRLK 4692
Query: 1966 SQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHE 2022
QT +R S L+ S +H+ ++ E ++ + + + K+ E L + +
Sbjct: 4693 RQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEE-------TLPAEEKLK 4745
Query: 2023 LFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL-KLTLLSNQWQGVIRRAQQRRG- 2080
++ + S Q I++ + + D K WQG ++ G
Sbjct: 4746 MYHSLAGSLQD--SGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGE 4803
Query: 2081 -IIDSQIRQWQRYREMAEKLRK--WLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV 2137
+ + + R Q E R WL V +SG + + LQ + ++Q ++
Sbjct: 4804 TVTECESRMVQSIDFQTEMSRSLDWLRRVK-AELSGPVYLDLNLQDIQEEIRKIQIHQEE 4862
Query: 2138 FLRQQGSYILTVEAGKQL--------LLSADSGAEAALQAEL-AEIQEKWKSASMRLEEQ 2188
Q I+ + K+ L+SAD A +EL +IQE ++ L E
Sbjct: 4863 V--QSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI 4920
Query: 2189 KKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSW 2248
+ + ++ + D+ E L+ L + + + H E ++ +
Sbjct: 4921 YSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTED------QF 4974
Query: 2249 TDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 2308
+L +L L TL I L ++V L+ + + + + + +W
Sbjct: 4975 HSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHD 5034
Query: 2309 FSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA-----QENKIQLQQM 2363
+ + +E+ E + E K+S+ + E +K + + ++ E + L++
Sbjct: 5035 YQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEK 5094
Query: 2364 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 2423
+L K +++ + + + V RW L + + K L++ + + +
Sbjct: 5095 ASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE 5154
Query: 2424 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 2483
+ ++ +L + + E+ L ++E+ + + + +L D A
Sbjct: 5155 MIDQLQDKLPGSSA-EKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAA 5213
Query: 2484 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-- 2541
E +Q+ T DR C E K++ +L ++ L D E + S
Sbjct: 5214 PTPGEEPPLMQEITAMQDR-----CLNMQE---KVKTNGKLVKQELKDREMVETQINSVK 5265
Query: 2542 --SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL-ELINKQYRRLARENRTDS 2598
+ T + + + EEL+ + + ++ E ++Y L ++
Sbjct: 5266 CWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSEL 5325
Query: 2599 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 2658
+ L ++ + R D +Q ++ + + + + + LT++ + N+
Sbjct: 5326 SLQLAEVALDLKIR-DQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNV 5384
Query: 2659 EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEE--ELDEL 2716
VQAK Q K +E+ ++K+ ++ A ++ +E++ L + ++ +L EL
Sbjct: 5385 -------VQAKTDQ-KVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTEL 5436
Query: 2717 -RRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSP 2775
++ ++ R+ + ++ L ++ +L + +E A + W+ SA L
Sbjct: 5437 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWN--SASQLRE- 5493
Query: 2776 QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ 2835
L Q L E D+ + L++ + + ++ L E EE +
Sbjct: 5494 ------QYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE-LGRETEELR 5546
Query: 2836 DDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE-----L 2890
L+ + D E+++++L AL+ ++ T T PE L
Sbjct: 5547 QMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ------------ATLTSPEVGRLSL 5594
Query: 2891 DTSYKGYMKLLGECSS---SIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWEL 2947
LL E S + +V+ + L+ E+ + H+ + +
Sbjct: 5595 KEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA----ALRLQEEASR 5650
Query: 2948 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 3007
LQ A+ + M+ + +++Q+ ++ + + E+E + +++IQ ++ QI
Sbjct: 5651 LQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIE--DKPVATSNIQELQAQIS 5708
Query: 3008 KLKELQKAVDHRKAIILSIN 3027
+ +EL + + + I S+N
Sbjct: 5709 RHEELAQKIKGYQEQIASLN 5728
Score = 117 bits (293), Expect = 2e-25
Identities = 630/3375 (18%), Positives = 1244/3375 (36%), Gaps = 527/3375 (15%)
Query: 19 KPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML------ELILKWIEKAKV 72
K K KL LHQ+ R + L Q L++Y+ + E L+ +++ +V
Sbjct: 3488 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQV 3547
Query: 73 -LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVA 131
A G NS RE I E D LE++ + Q ++S+
Sbjct: 3548 HCAEGQALLNSVLHTREDVIPSGIPQAE----DRALESLRQDWQAYQ-----HRLSETRT 3598
Query: 132 ELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKKLQAALEQ----AQATLTSPEVG 185
+ +LR M + + Q + + K + KK+ E+ + +E+ AQ L V
Sbjct: 3599 QFNNVVNKLRLMEQ-KFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVN 3657
Query: 186 -RLSLKE-QLSHRQH-----LLSEMESLKPKVQAVQLCQSALRIPEDVVASLP--LCHAA 236
R+ + QL+ R +L +++ L+ ++Q+++ +S+L D S + A
Sbjct: 3658 SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVA 3717
Query: 237 LRLQEEASRLQHTAIQQCNIMQAAVVQ--------YEQYEQEMKHLQQ-----LIEGAHR 283
++ + + + ++ ++ + + E+ E+ +K+L++ L + H
Sbjct: 3718 TKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHD 3777
Query: 284 EIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 343
+E TS +++ + + LA++ + KCK LT +L V
Sbjct: 3778 HMEQLKELTSTVRKEHMTLEKGLHLAKEF----------SDKCKALTQWIAEYQEILHVP 3827
Query: 344 EVEG--LAEGTEDLDG--ELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISS 399
E L E L L T +H V + LL V + + ++ + S
Sbjct: 3828 EEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSD 3887
Query: 400 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATA 459
+ + ++ ++IA ++ +RL K + + L+ + A
Sbjct: 3888 Y------QDLCSIGKAMMEEIAGFE----DRLNNLQMKGDTLIGQCADHLQAKLKQNVHA 3937
Query: 460 KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP--G 517
L + S+ + + ++L L++ QD+LQ + A++ L SP+P
Sbjct: 3938 HLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLS 3997
Query: 518 RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAER 577
R+ + +H + E Q+ +L+ C+ A
Sbjct: 3998 RAEAIKQVKHFRALQE-----------QARTYLDLLCSMCDLSNAS-------------- 4032
Query: 578 MSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP 637
+ T Q +E+KL ++ Q Q + + EL W+ A D L
Sbjct: 4033 VKTTAKDIQQTEQTIEQKL---VQAQNLTQGWEEIKHLKSEL--WIYLQDA--DQQLQNM 4085
Query: 638 KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLK 697
K E +L QNM+ +++ V L ++ + TK E ++ L
Sbjct: 4086 KR-RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4144
Query: 698 GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS--- 754
L+L R ++ L + Q + + V+ +L + T W +S
Sbjct: 4145 DQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNV-----VEVFLEKFTTEWDNLARSDAES 4199
Query: 755 ----LQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEG 810
L+ K+L L E+K + + + ++ +I+H + +K V Q +E
Sbjct: 4200 TAVHLEALKKLALALQERKYAIEDLKDQKQK-MIEHL------NLDDKELVKEQTSHLEQ 4252
Query: 811 EKSSAEDQMRMKWE---SLHQEFSTKQKLLQNVLEQEQEQVLYSRPN---RLLSGVPLYK 864
ED ++ K + + +E + Q Q ++E +EQ +PN L P
Sbjct: 4253 RWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ----QPNIAEALKQSPPPDM 4308
Query: 865 GDVPTQDKSAVTS-------LLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTW 917
D A+ S LL L + + V + G +RQ I ++ L D S +
Sbjct: 4309 AQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVI--QKALSDAQSHVNCL 4366
Query: 918 LDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDV 977
D V +R L E+T Q ++A + + K +F + D DV
Sbjct: 4367 SDLVGQRRKYLNKALSEKT------QFLMAVFQATSQIQQHERKIMFREHICLLPD--DV 4418
Query: 978 IEDTLGCLLGRLSL--LDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 1035
+ C + SL + V Q +E ++++ Q +VL LQ+L
Sbjct: 4419 SKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTE-QEKSEVLGK---------LQEL 4468
Query: 1036 ANVFEQPVAEQIEAIQQAEDGL-------KEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 1088
+V++ + + +Q+ E L ++FD LK+ E M E S+L
Sbjct: 4469 QSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELH 4528
Query: 1089 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 1148
+ I+ N LTL +R Q + L ++ + + +
Sbjct: 4529 TQLAKYQNILEQSPEYENLLLTL----QRTGQTILPSLNEVDHSYLSEKLNALPRQFNVI 4584
Query: 1149 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 1208
L K K Y IL + +I Q ++ + + + A + + L
Sbjct: 4585 VALAKDKFY---KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSL 4641
Query: 1209 E----YILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKS--- 1261
+ IL+ + L E EL+++ E S+ D+++ +TLY LK
Sbjct: 4642 QDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQ-----PWQPDKMLHLVTLYHRLKRQTE 4696
Query: 1262 ---SLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETIL 1318
SL E YQ + C LE QL + E +K+++E E L
Sbjct: 4697 QRVSLLEDTTSAYQEHEK--------MCQQLERQLKSVKE----EQSKVNEETLPAEEKL 4744
Query: 1319 KHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSS 1378
K + D L+ LE P E R + ++ K + S+
Sbjct: 4745 KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH--LDPLAYEKARHQIQSWQGELKLL--TSA 4800
Query: 1379 LKSSVLSTGNQLLRLKKVDTATLRS--ELSRIDSQWTD---LLTNIPAVQEKLHQLQMDK 1433
+ +V +++++ T RS L R+ ++ + L N+ +QE++ ++Q+ +
Sbjct: 4801 IGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ 4860
Query: 1434 LPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDF 1493
EV S + +M + K+++ + K+L
Sbjct: 4861 -------EEVQSSLRIMNALSHKEKEKFTKA----------------------KELISAD 4891
Query: 1494 VNQSVLQISSQD---VESKRSDKTDFAEQLGAMNKSWQILQGL------VTEKIQLLEGL 1544
+ S+ ++S D E+ R+ + E + +Q+ Q E +QL
Sbjct: 4892 LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNG 4951
Query: 1545 LESWSEYENNVQCLKTWFETQEK---RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE 1601
L+ S E N++ +F T+++ L++ H + L+ LIK KE
Sbjct: 4952 LDVESA-EENLKSHMEFFSTEDQFHSNLEELHSL------------VATLDPLIKPTGKE 4998
Query: 1602 VEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKV 1661
+ ++ V+S+ + + R + A +D LL+ QW ++
Sbjct: 4999 -------------DLEQKVASLELRSQRMSRDSGAQVD--------LLQRCTAQWHDYQK 5037
Query: 1662 AFDKINSYLMEARYSLSRFRLL-TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQ 1720
A +++ + + LS F LL T S + ++ + L + + +Q
Sbjct: 5038 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5097
Query: 1721 LLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQ 1780
L K + TL+ ++ V RW L +Q + + + W + + K+ +
Sbjct: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
Query: 1781 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 1840
Q +D+ L ++ + + E+ T ++ + + L + +L L + + Q
Sbjct: 5158 QLQDK----LPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ---- 5209
Query: 1841 SAASAIQSDQLSLSQHLCALEQALCKQQTSLQAG-------VLDYETFAKSLEALEAWIV 1893
A+ ++ L Q + A++ Q ++ + D E + +++ W+
Sbjct: 5210 DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ 5269
Query: 1894 EAEEILQGQDPSHSSDLSTIQ-------------ERM-EELKGQMLKFSSMAP-DLD-RL 1937
E +E L + L +Q E+M EE K + L ++ P +L +L
Sbjct: 5270 ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQL 5329
Query: 1938 NELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 1997
E+ L + D+ +++ + + S +SQ R ++Q T L K + + +V
Sbjct: 5330 AEVALDLKIRDQIQDKIKEVEQ--SKATSQELSR--QIQKLAKDLTTILTKLKAKTDNVV 5385
Query: 1998 Q--TEQK-LAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDR 2054
Q T+QK L E+ G L+E A + F L + GQ+
Sbjct: 5386 QAKTDQKVLGEELDGCNSKLMELDAAVQKF--------------------LEQNGQLG-- 5423
Query: 2055 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 2114
K+ L+ Q IR+A+ R ++ + Y EM E + KW+ + L
Sbjct: 5424 KPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVL----- 5478
Query: 2115 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEI 2174
+ + LR+Q YIL Q LL ++ L+A ++
Sbjct: 5479 ------------AHGTIAWNSASQLREQ--YIL-----HQTLLEESKEIDSELEAMTEKL 5519
Query: 2175 Q--------EKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD 2226
Q EK L + ++L ++K + + A ++K KKL +L
Sbjct: 5520 QYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579
Query: 2227 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA-YISADDISILNERVELLQRQW 2285
L + ++ L+ + L+++ LK + A + + I + V L
Sbjct: 5580 AQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASL---- 5635
Query: 2286 EELCHQLSLRRQQIGERLNEWAV---------------FSEKNKELCEWL----TQMESK 2326
LCH +LR Q+ RL A+ + ++ K L + + ++E K
Sbjct: 5636 -PLCH-AALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDK 5693
Query: 2327 VSQNGDI--------LIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHES---K 2375
+I EE+ +K+ K YQE+IA + +K ++ M KA H +
Sbjct: 5694 PVATSNIQELQAQISRHEELAQKI-KGYQEQIA-SLNSKCKMLTM-----KAKHATMLLT 5746
Query: 2376 ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKP 2435
+E+E D LL +A + T L ++ + SE++ P
Sbjct: 5747 VTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE-ESGEEGTNSEISSP 5805
Query: 2436 IVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQ 2495
+C S N + +DI + A L +H + + + ++
Sbjct: 5806 ---PACRSP--SPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEP 5860
Query: 2496 ATR----NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS 2551
+ +L R W + + E++ + E QK+ D +++ E +
Sbjct: 5861 SATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPE 5920
Query: 2552 SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA-------CSLKQ 2604
G + + Q + E L + IN+ LA E ++S +L+
Sbjct: 5921 PG------RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQS 5974
Query: 2605 MVHEGNQRWDNLQKRVTSILRRLKHFIG-----QREE-----FETARDSILVWL--TEMD 2652
+ +R ++ + + + L+ + QR+E + D + WL T+
Sbjct: 5975 TLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
Query: 2653 LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 2712
L D++A++ + EI + ++ E L+ + + E+
Sbjct: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
Query: 2713 LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 2772
+LRR + H K + + E + SD +L S + + W ++ +
Sbjct: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQE--WLAQARTTW 6152
Query: 2773 LSPQPSS-NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSED 2831
+ SS L Q L ++S + AS E + + +E
Sbjct: 6153 TQQRQSSLQQQKELEQELAEQKSLLRSVASRG----------------EEILIQHSAAET 6196
Query: 2832 EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQ--TENIIRSKTPTGPE 2889
+K L +G+ G+ S+ E Q+R ++L F +Q +N++ +
Sbjct: 6197 SGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESL-HQEFSTKQKLLQNVLEQEQE---- 6251
Query: 2890 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQ 2949
L + + V + + +++S + + G+ +E +
Sbjct: 6252 --------QVLYSRPNRLLSGVPLYKGDVPTQDKS--------AVTSLLDGLNQAFEEVS 6295
Query: 2950 AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL---ELSTDIQTIELQI 3006
+Q+ + +Q++ Q+ +++ WL D EE L L E T + E+
Sbjct: 6296 SQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILA 6352
Query: 3007 KKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRD-LQDRLSQMNGRWDRVCSLLEEW 3065
K +KE+ + +D K NL S F ++ ++RD ++D L + GR + S++ +
Sbjct: 6353 KDIKEMSEEMDKNK------NLFSQAF--PENGDNRDVIEDTLGCLLGRLSLLDSVVNQR 6404
Query: 3066 RGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHE 3125
+++ L Q F + L ++ ++ K I+ +N+ + + + + + Q +
Sbjct: 6405 CHQMKERLQQILNF---QNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDG 6461
Query: 3126 LLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVH-----VIGNR---LKLLLKEVSRHI 3177
L E + L+ +L V L + ++ +IG+R L L S++
Sbjct: 6462 LKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYE 6521
Query: 3178 KELEKLLDVSSSQQD 3192
+ L+ L D+ + Q+
Sbjct: 6522 RALQDLADLLETGQE 6536
Score = 105 bits (261), Expect = 1e-21
Identities = 396/2090 (18%), Positives = 783/2090 (37%), Gaps = 300/2090 (14%)
Query: 1137 QKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAV-----QKETQFHTELM 1191
Q++ + IQ+ L++HK+ Q ++H ++R + Q E
Sbjct: 439 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 498
Query: 1192 AQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLID 1251
+++ L +EL+Y L + L E + ++S I G E E L +
Sbjct: 499 VSSTSELHLMKMEFLELKYRLLSLLVLAESK---------LKSWIIKYGRRESVEQLLQN 549
Query: 1252 RITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQ-----LNQLGECWLSNTNK 1306
++ ++ S E YQ+L + + S E++ +N+ W + + +
Sbjct: 550 YVSFIEN--SKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE 607
Query: 1307 MSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL--------EFWTQQSVTVPQELEM 1358
+ LE ++ +W RY + A L WL+ A+ L +F+ + Q M
Sbjct: 608 VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 667
Query: 1359 VRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTN 1418
D N +E E+ ++ + +L G +V E+ R+ ++TD +
Sbjct: 668 -NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT 726
Query: 1419 IPAVQEKLHQLQMDKLPSRHA--------ISEVMSWISLME---NVIQKDEDNIKNSIGY 1467
+ A + H+ + L + ++ + +M+ +I K I
Sbjct: 727 LSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQ 786
Query: 1468 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV----ESKRSDKTDFAEQLGAM 1523
+ E K +QLT S L SQ + E T F + LG +
Sbjct: 787 EEGKEMFATMSKLK-----EQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKI 841
Query: 1524 NKSWQILQ------GLVTEKIQLL----EGLLESWSEYENNVQCLKTWFETQEKRLKQ-- 1571
N+ +L+ L +K Q L E ++ + E Q ++ F T LK
Sbjct: 842 NEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQK-FVTLSNVLKHFD 900
Query: 1572 ----QHRIGD-QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMS 1626
Q +I D + Q+ +K D + ++ + ++K E++ L E V I
Sbjct: 901 QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAEL-----EKVLRIAQE 955
Query: 1627 TLRELG----------QTWANLDHMVGQLKILLKS------VLDQWSSHKV--AFDKINS 1668
L E G + ++ LD V L LK+ +L + + A K++
Sbjct: 956 GLEEKGDPEELLRRHTEFFSQLDQRV--LNAFLKACDELTDILPEQEQQGLQEAVRKLHK 1013
Query: 1669 -----------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNL--QDDLEKQERSLQKFG 1715
+L+ + + + R L S+E + ++D L Q+ EK + + F
Sbjct: 1014 QWKDLQGEAPYHLLHLKIDVEKNRFLA-SVEECRTELDRETKLMPQEGSEKIIKEHRVFF 1072
Query: 1716 SITN---------QLLKEC------HPPVTETLTN---TLKEVNMRWNNLLEEIAEQLQS 1757
S QL++E PV +T TLKE+ ++ ++ E
Sbjct: 1073 SDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK 1132
Query: 1758 SKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI--ADDEVATWIQDCNDLLK 1815
K R+ ++S ++ Q + E + A + ++ A +E+ + + L
Sbjct: 1133 WK---DYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLS 1189
Query: 1816 GLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQAL-----CKQQTS 1870
L K L L E+ + + Q + + S +L L +E+ L C Q
Sbjct: 1190 WL---KSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKE 1246
Query: 1871 LQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSM 1930
+ L+ E + S E E +AE+IL ++ + L + ++ K K +
Sbjct: 1247 IVKNSLE-ELISGSKEVQE----QAEKILDTENLFEAQQL--LLHHQQKTKRISAKKRDV 1299
Query: 1931 APDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990
+ + + LP D+ + ++ L + + ++Q L + + F E
Sbjct: 1300 QQQIAQAQQGEGGLP--DRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1357
Query: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 2050
T + +L QT +S + L EL Q + FS++ SI + + L+++
Sbjct: 1358 TVVRYLFQTGSSHERFLSFSSLESLSS----ELEQTKEFSKRT--ESIAVQAENLVKEAS 1411
Query: 2051 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR-------QWQRYREMAEKLRKWL 2103
N +L L Q + + + ++ ++ I+ +W + E L W+
Sbjct: 1412 EIPLGPQNKQL--LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWI 1469
Query: 2104 VE----VSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSA 2159
E ++ L S ++ + + Q + E++ K S + E +
Sbjct: 1470 TEKEKELNALETSS-SAMDMQISQIKVTIQEIESK-------LSSIVGLEEEAQSFAQFV 1521
Query: 2160 DSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK 2219
+G A ++A+L +I+ R E+ ++ A L E G +K +K
Sbjct: 1522 TTGESARIKAKLTQIR--------RYGEELREHAQCL---EGTILGHLSQQQKFEENLRK 1570
Query: 2220 LSQSLPDHHEELHAEQMRCK---ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN- 2275
+ QS+ + ++L C E + D L L ++A+ SA ++N
Sbjct: 1571 IQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAF-SASARKVVNR 1629
Query: 2276 ----ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ-- 2329
+ LQ+Q+E++ + R+ + L W ++ WL + E+K S
Sbjct: 1630 DSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPE 1689
Query: 2330 ---NGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKV 2386
+ D + E +L + Q E+ +L Q+ E L + + ++ L ++
Sbjct: 1690 MDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQL 1749
Query: 2387 NDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK-----------P 2435
++RW+ L +I R+ L+ + QQ D+ + S W+ SEL
Sbjct: 1750 DERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA 1809
Query: 2436 IVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGVASVLNLCEVLLHDCDACATDAE--CDS 2492
+ ++ E++ K E Q LQ + K S G A L+L + DC +A +
Sbjct: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVER 1869
Query: 2493 IQQATRNLDRRWRNICAMS---MERRLKIEETWRLWQKFLDDYSR-FEDWLKSSERTAAF 2548
Q A +L ++ ++S + R +E T + + D + D L++++ +
Sbjct: 1870 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESA 1929
Query: 2549 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-----ARENRTDSACSLK 2603
S I + A+ LK + QR C + + + R+ +++ D+ LK
Sbjct: 1930 AVSLDGILSKAQYHLKIGSSEQRT--SCRATADQLCGEVERIQNLLGTKQSEADALAVLK 1987
Query: 2604 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 2663
+ + + + L K + I R +E A L +++ +L + EH
Sbjct: 1988 KAFQD---QKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDELNSHEH-EL 2042
Query: 2664 CDVQAKIKQLK----AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE--EELDELR 2717
C ++ K KQ+ AF E+ N++E ++LI +++ +I+ E L+
Sbjct: 2043 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2102
Query: 2718 RYCQEVFGRVERYHKKLIRLPLPDDEHDL--------------SDRELELEDSAA----- 2758
+V +E ++ D+ DL + ++ +L++ +
Sbjct: 2103 SAVSKV---LENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHL 2159
Query: 2759 LSDLHWHDRSADSLLSPQPSSNLS--LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS 2816
LS+L S SL+ S + L +++ L S+ WD
Sbjct: 2160 LSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSI------WDDVLSTR 2213
Query: 2817 RDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQT 2876
++E + +P + E + D +LR L ES+++ L++ ++
Sbjct: 2214 DEIEGWSNNCVP-QMAENISNLDNHLRAEELL----KEFESEVKNKALRLEELHSKVNDL 2268
Query: 2877 ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 2936
+ + ++ T P+L D +++LEH + E + + + T
Sbjct: 2269 KELTKN-LETPPDLQ-------------FIEADLMQKLEHAKEITEVAKGTLKDFTAQST 2314
Query: 2937 QTAGVIDRWELLQAQALSKELRMKQN-----LQKWQQFNSDLNSIWAWLGDTEEELEQLQ 2991
Q I+ + + QN L+K + +L S + + T+E L L
Sbjct: 2315 QVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLC 2374
Query: 2992 RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 3041
R S +++++ + L + +AV LCS TQA +ES
Sbjct: 2375 RKYHSAELESLGRAMTGLIKKHEAVS---------QLCSK--TQASLQES 2413
Score = 41.6 bits (96), Expect = 0.013
Identities = 46/220 (20%), Positives = 81/220 (36%), Gaps = 45/220 (20%)
Query: 2920 EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 2979
EE E++ F+N ET +W L + S +++ + W ++ + + S+ AW
Sbjct: 585 EEAENVMKFMN----ETTA-----QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAW 635
Query: 2980 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 3039
L D E+ L Q + + + L + A+ + N D
Sbjct: 636 LEDAEKMLNQSENAKKDF-----------FRNLPHWIQQHTAMNDAGNFL---IETCDEM 681
Query: 3040 ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNE 3099
SRDL+ +L +NGR WR L + Q + +DR K E
Sbjct: 682 VSRDLKQQLLLLNGR----------WRELFMEVKQYAQA------------DEMDRMKKE 719
Query: 3100 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 3139
L A + H K ++ + +L + L+D+
Sbjct: 720 YTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDI 759
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
[Homo sapiens]
Length = 6907
Score = 1956 bits (5068), Expect = 0.0
Identities = 1204/3338 (36%), Positives = 1863/3338 (55%), Gaps = 120/3338 (3%)
Query: 27 KLTELHQQTIRQAENRLSKLNQAASHLEEY--NEMLELILKWIEKAKVLAHGTIAWNSAS 84
K +E++ + E+++ + +A ++E NE+L+ + + K+ N
Sbjct: 3645 KYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEK 3704
Query: 85 QLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY--CTEKMSQQVAELG-------R 135
L+++ + E K++ EL+ KL L S E+ Q E +
Sbjct: 3705 MLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQ 3764
Query: 136 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 195
+ +++ Q + R L A M+++ LK +A +E L +P LSH
Sbjct: 3765 QYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSH 3822
Query: 196 RQHLLSEMESLKPKVQAVQLCQSALRIPED---VVASLPLCHAALRLQEEASRLQHTAIQ 252
H + +L+ Q L S ED + + L + L + + LQ ++
Sbjct: 3823 --HASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIME 3880
Query: 253 QCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKI 312
+Q E E+K +++ + + K + + +E + E + + I
Sbjct: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE---HLKHGEVILENI 3937
Query: 313 KGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMM 372
+ ++ IA + S L + L L + + L+ V+
Sbjct: 3938 RPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQ 3997
Query: 373 TAGRCHTL--LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS--A 428
T + L + + + +S A + P + Q ++ Q
Sbjct: 3998 TNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLL 4057
Query: 429 ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALER 488
L+ +H QE E P+ T++ G + + SE++ ++
Sbjct: 4058 VDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVA------ERDASERKLNRRGSMSY 4111
Query: 489 QQKYQDSLQSISTKMEAIELKLSESPEPGRS---PESQMAEHQALMDEILMLQD---EIN 542
++ ++ S K + + K SP+ S + M E +A ++Q+ +I+
Sbjct: 4112 LAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKIS 4171
Query: 543 ELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL-LEEKLNDQLE 601
+S+A+ L +S + + +L+ T E +T ++A + L ++E
Sbjct: 4172 TSDNSMAQILTPDSLNTEQGPECSLRPNQT---EEGTTPPIEADTLDSSDAQGGLEPRVE 4228
Query: 602 EQRQE--QALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQ 659
+ R E + L + + EL+ WL ++ +E QL+ CQ ML EIE
Sbjct: 4229 KTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEH 4288
Query: 660 KVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ 719
KV L E ++ L T+ EAE L+ KL+ +K +L ++Q L +K Q
Sbjct: 4289 KVAFLLETC---KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTI 4345
Query: 720 EKEESDVDLTATQSPGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASR 778
K+ S+ + P L T Q RQ QQQ+ LE + EQK ++ +
Sbjct: 4346 LKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFN 4405
Query: 779 GEEILIQHSAAE--TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKL 836
+++ Q+ + T+ ++ S E + S + Q KW+ LH E S+K KL
Sbjct: 4406 AKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKL 4465
Query: 837 LQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGG 895
L + Q S +L V +Y PT ++ T+ L+ L Q + +Q
Sbjct: 4466 PLPQLVEPQ----VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENM 4521
Query: 896 AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSE 955
+ I+L++KL++ S L VEE L + L E+ + E LA ++K++
Sbjct: 4522 TEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPR-LYREDGSGQQVHYETLALELKKLYL 4580
Query: 956 EMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQN 1015
+ K +A G+N +++ + L L + R +K L ++QN
Sbjct: 4581 ALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQN 4640
Query: 1016 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 1075
++K L+ L +K + Q L + Q VAEQ++ L+ ++ + +L+ G++L
Sbjct: 4641 EIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLH 4700
Query: 1076 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 1135
+ +QE+ KL+D+ D + ++ +R + L+ +SQ + LQ + +L++ G+EK+A
Sbjct: 4701 LPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAH 4760
Query: 1136 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 1195
SK +Q ++ HK +FQ L + M+L + KI+ +Q F E + +
Sbjct: 4761 GHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVK 4820
Query: 1196 AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL 1255
+ +++ + G++L+ +L+ W DE+ L + LE++ S++PSV LVEE E+RL++RI+
Sbjct: 4821 ILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISF 4880
Query: 1256 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 1315
YQ +K ++ +LYQ L++GK+L+ S+SC +LE Q+ +L E WLS K+ ELHRL+
Sbjct: 4881 YQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
Query: 1316 TILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDA 1375
+LKH Y +S L WL+S++ L +W +QS+ V Q+L+ +R ++N F EFSKEVD
Sbjct: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
Query: 1376 QSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 1435
+SSLK++V+S GNQLL LK+ DTATLR+ L++ + +WT L+T +P +QEKLHQLQM+KLP
Sbjct: 5001 KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
Query: 1436 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 1495
SR AI+E++SW++ +E+ DED++ + + LQK+K F+++++ KQ VDFVN
Sbjct: 5061 SRKAITEMISWMNNVEHQTS-DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
Query: 1496 QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 1555
QS+LQ+S+ DVESKR ++T+FAE LG MN+ W + G++ KIQ LE LLES +E EN +
Sbjct: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
Query: 1556 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 1615
Q L W E QE+RLK + SVQ L DCQD+E+ + K K +++++Q+ L L ++
Sbjct: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL-ES 5238
Query: 1616 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARY 1675
+ S + EL Q +++ V QLK ++SVL +W + +D++N + Y
Sbjct: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
Query: 1676 SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTN 1735
+ + + SLE ++ QV+NLQ+LQD+ E E S +K + +L C P V E +
Sbjct: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEE 5357
Query: 1736 TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN 1795
+ + RW + + IA+QLQ +++LLQLW+ Y + + A+ ++QQE + +L + +
Sbjct: 5358 KCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMS 5417
Query: 1796 KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQ 1855
+ + + +QD +L + K++ + ++L Q ++S + SL Q
Sbjct: 5418 GNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-Q 5476
Query: 1856 HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQE 1915
LE+ L + + + ++ F LE+L+ I+ EE L D H + +E
Sbjct: 5477 RAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---DRLHQQE----KE 5529
Query: 1916 RMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL 1975
+ +L ++ +PD++ LNE+ +LPL+D +K +QN+NR W ++ ER S+L
Sbjct: 5530 NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSEL 5589
Query: 1976 QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQIL 2035
Q L ++ FL CE W++ L + E+ L V+++ + LLEQQ+ +++ +AE+ Q I
Sbjct: 5590 QGIGL-NEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIA 5648
Query: 2036 HSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 2095
S + +LL+ ++++R EF + + L+++WQ ++ +QR+G +D +RQWQ +
Sbjct: 5649 DSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTS 5708
Query: 2096 AEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL 2155
E L ++L + S+L + G L Q R+L E++ KE F R++ + LT+EAG++L
Sbjct: 5709 VENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKL 5768
Query: 2156 LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT 2215
LL+ D + ++ ++++Q+ WK +L E K+ ++ W++CEK I + +L+
Sbjct: 5769 LLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQV 5828
Query: 2216 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 2275
K + LP+ HE+LH E+ KELE ++ SWT +L +L +K L+ ++ +D+ +L
Sbjct: 5829 LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK 5888
Query: 2276 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI 2335
E++E L RQWE+LC ++++R+Q+I +RLN W VF+EKNKELC WL QME+KV Q DI I
Sbjct: 5889 EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISI 5948
Query: 2336 EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLD 2395
EEMIEKL+KD EEI + ENK+QL+QMG++L KAS++S+A+EI+ KL K+NDRWQHL D
Sbjct: 5949 EEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFD 6008
Query: 2396 LIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQE 2455
+I +RVKKLKET +QQLDKNMS+LRTWLA IESEL+KP+VYD C+ +EIQ++L EQQ+
Sbjct: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQD 6068
Query: 2456 LQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR 2515
LQRDIE+HS GV SV N+C+VLLHD DACA + ECDSIQQ TR+LDRRWRNICAMSMERR
Sbjct: 6069 LQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR 6128
Query: 2516 LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE 2575
+KIEETWRLWQKFLDDYSRFEDWLKS+ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE
Sbjct: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHE 6188
Query: 2576 CLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE 2635
LTQLELINKQYRRLARENRTD+A LKQMVHEGNQRWDNLQ+RVT++LRRL+HF QRE
Sbjct: 6189 RLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQRE 6248
Query: 2636 EFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGE 2695
EFE R+SILVWLTEMDLQLTN+EHFSE D K++QL FQQEI+LN NKI+Q+I GE
Sbjct: 6249 EFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGE 6308
Query: 2696 QLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELE 2754
QLI+KSEPLDA +IE+EL+EL RYCQEVFGRV R+H++L P +DE + S+ E ++E
Sbjct: 6309 QLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDME 6368
Query: 2755 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD 2814
D + W R S +PSS SL ERSG +TP SVDSIPLEWDH D
Sbjct: 6369 DPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGD 6424
Query: 2815 L------SRDLESAMSRALPSEDEEGQDDKDFYLR---GAVGLSGDHSALESQIRQLGKA 2865
+ D E AL D E ++ + YL+ + S S + + +
Sbjct: 6425 VGGSSSHEEDEEGPYYSAL--SDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDS 6482
Query: 2866 LDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEE 2922
+Q E R+ P P T YK G + L + + L ++E+
Sbjct: 6483 PSCPEHHYKQMEG-DRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQED 6541
Query: 2923 ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGD 2982
L G Q +G DRWE++QAQ L +L++KQNL QQ NSD+++I WL
Sbjct: 6542 GGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKK 6592
Query: 2983 TEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR 3042
TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES
Sbjct: 6593 TEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPEST 6652
Query: 3043 DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVP 3102
+LQ RL Q++ W+ ++ WRG L+ +LMQCQ FH++S LLL L + R+ +
Sbjct: 6653 ELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHV 6712
Query: 3103 IDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI
Sbjct: 6713 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 6772
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKT 3222
+LK L ++VS + L+ + +Q S S DE+D SG P +
Sbjct: 6773 EKKLKQLREQVS------QDLMALQGTQNPASPLPSFDEVD-SGDQPPAT---------- 6815
Query: 3223 PRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLL 3282
S P P R+T+G ++ PG R R FL RV+RAALPLQLLLLLL
Sbjct: 6816 -------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLL 6868
Query: 3283 IGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 3320
+ LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 6869 LLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 6906
Score = 218 bits (554), Expect = 1e-55
Identities = 505/2767 (18%), Positives = 1073/2767 (38%), Gaps = 296/2767 (10%)
Query: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
ELD+ VQ +EQ+ + + + +QQ ++AE R S+LN+A +EEY+++L+
Sbjct: 3736 ELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLK 3795
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
WIE L ++S L Q LE+S++ + L ++ L+ L+ ++
Sbjct: 3796 STEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIF 3855
Query: 122 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTS 181
T++++Q + EL + L+Q I L +Q A D+ E+E+K ++ + + + L S
Sbjct: 3856 ETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLS 3915
Query: 182 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQE 241
E+ S +E L H + +L + +K + + Q LR+P+ + LP+ +L +
Sbjct: 3916 KEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQ 3975
Query: 242 EASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE--GAHREIED-KPVATSNIQEL 298
+ L++ +Q +++ + Q ++++E+++L+Q++ A +E P + +L
Sbjct: 3976 DIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQL 4035
Query: 299 QAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE----- 353
Q +I R E +QI SLN + + L + K AT+L ++ EG E
Sbjct: 4036 QGEIERME----------KQILSLNQRKEDLLVDLK-ATVLNLHQHLKQEQEGVERDRLP 4084
Query: 354 ---DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVA 410
+G + ++ + + + EES + N + + P+ +S S +
Sbjct: 4085 AVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLW 4144
Query: 411 NTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEP-----------GLEPSATA 459
D + +D A + S +Q KI S ++ + P L P+ T
Sbjct: 4145 KHDKDMEEDRA--SSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQTE 4202
Query: 460 KLGDLQRSWETLKNVISEKQRTLYEALER-QQKYQDSLQSISTKMEAIELKLSESPEPGR 518
+ +TL + S+ Q L +E+ + + + L + T++ +EL L ++
Sbjct: 4203 EGTTPPIEADTLDS--SDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQA-NVAV 4259
Query: 519 SPESQMAEHQALMDEILM-LQDEINELQSSLAEELVSESC-EADPAEQLALQSTLTVLAE 576
PE+ A+ Q ++++ L+ Q + E++ +A + E+C + + A Q L+
Sbjct: 4260 EPETLNADMQQVLEQQLVGCQAMLTEIEHKVA--FLLETCKDQGLGDNGATQHEAEALSL 4317
Query: 577 RMSTIRMKASGKRQLLEEKLND--------QLEEQRQEQALQRYRCEADELDSWLLSTKA 628
++ T++ + +L+EK ++ + E ++ALQ EL+S + T+
Sbjct: 4318 KLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQ--PVNLSELES--IVTER 4373
Query: 629 TLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVAL-SELSVHNENLLLEGKAHTKDEAE 687
+ ++ +E + M+ ++ + IE + + H+ + E A +
Sbjct: 4374 PQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSA-----SN 4428
Query: 688 QLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK--------EESDVDLTATQSPGVQEW 739
Q + + S+L Q DK + K E V P V +
Sbjct: 4429 QASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMY 4488
Query: 740 ------LAQARTTWTQ-----QRQSSLQQQK--------ELEQELAEQKSLLRSVASRGE 780
+ +T TQ Q S+LQ Q+ L+++L E L S E
Sbjct: 4489 NFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVE 4548
Query: 781 EILIQHSAAETSGDAGE-KPDVLSQE-----LGMEGEKSSAEDQMRMKWESLHQEFSTKQ 834
E+L G + + L+ E L + +K M E+ +
Sbjct: 4549 EMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFD 4608
Query: 835 KLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL---DGLNQAFEEVSS 891
LQ LE Q + R L +G+ Y + K L+ L Q+ E+S
Sbjct: 4609 N-LQVCLEHTQAAAV-CRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEISG 4665
Query: 892 QSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIK 951
QS + Q + + L D ERL + ALL E +
Sbjct: 4666 QSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE---------------VY 4710
Query: 952 EMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL----DSVVNQRCHQMKERL 1007
++ + +D + + E L G + L+ + + + Q K ++
Sbjct: 4711 KLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKV 4770
Query: 1008 QQILNFQNDLKVLFTSLADNKYI-------ILQKLANVFEQPVAEQIEAIQQAEDGLKEF 1060
+N KV F L + + IL L E AEQ+ ++ E+ ++
Sbjct: 4771 ALQAQIENH-KVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQC 4829
Query: 1061 DAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 1120
+ L ++ ++ S+++ ++ + ++ L + ++ Q +R +
Sbjct: 4830 GMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
Query: 1121 DL-ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGL----ESHMILTETLFRKI 1175
A L +T E G Q + S E++ + K +E + L + + + L + +
Sbjct: 4890 GKHARLYQTLNE---GKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHL 4946
Query: 1176 ISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESS 1235
+S+ +++ T+ + + ++ L W E +S+ L+ + S+
Sbjct: 4947 LSY--NRDSDQLTKWLESS--------------QHTLNYWK---EQSLNVSQDLDTIRSN 4987
Query: 1236 IPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL--LISISCSDLESQL 1293
I + + D KSSL V+ G +L L + L + L
Sbjct: 4988 INNFFEFSKEVDE-----------KSSLKT------AVISIGNQLLHLKETDTATLRASL 5030
Query: 1294 NQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVP 1353
Q + W ++ +L + + ++I W+ + + + + SV P
Sbjct: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS--DEDSVHSP 5088
Query: 1354 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSE-------LS 1406
V+ L EF E+D + + V LL+L D + R E L
Sbjct: 5089 SSASQVKHLLQKHKEFRMEMDYKQWIVDFV---NQSLLQLSTCDVESKRYERTEFAEHLG 5145
Query: 1407 RIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLME---NVIQKDEDNIKN 1463
++ QW + + + L QL S + I + +W+ E +QK E I
Sbjct: 5146 EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVI-- 5203
Query: 1464 SIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAM 1523
++ + L + + + K +D + QS L + S V + +
Sbjct: 5204 -----SVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPL-------LEDTASRI 5251
Query: 1524 NKSWQILQGLVTEKIQL---LEGLLESWSEY-----ENNVQCLKTWFETQEKRLKQQHRI 1575
++ +Q ++T+ QL ++ +L+ W Y E N+ ++ W+ + + +
Sbjct: 5252 DELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK----PVV 5307
Query: 1576 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTW 1635
+++ +++ Q L+D ++ E EK+ Q + ++ V+ I+ + + W
Sbjct: 5308 LSLETLRCQVENLQSLQDEAESSEGSWEKL-QEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
Query: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL--MEARYSLSRFRLLTGS--LEAVQ 1691
++ + +S+L W ++ A + + L EA++ ++G+ E +
Sbjct: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
Query: 1692 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751
+ +++ LQ D++K + + + S+ ++L P E+ T+ L L +
Sbjct: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRL-----PQPAESSTHMLLP------GPLHSL 5475
Query: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCN 1811
K LL ++ Q + E ++ N D +
Sbjct: 5476 QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFL 5535
Query: 1812 DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQS-DQLSLSQHLCALEQALCKQQTS 1870
+ + L + L+E+ LK + A +Q+ ++ + ALE+ Q
Sbjct: 5536 NHVLALTAQSPDIEHLNEV--SLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIG 5593
Query: 1871 LQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELK--------G 1922
L K L E WI E+I + ++ L + E+ + K
Sbjct: 5594 LN---------EKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
Query: 1923 QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH 1982
Q + S + L L+ + + I L W +R + + Q
Sbjct: 5645 QTIADSYVTQSLQLLDTT--EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQW 5702
Query: 1983 QTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA--HELFQAEM-FSRQQILHSII 2039
Q F E FL T L+ + G + L Q R+ HEL E+ F R++ ++
Sbjct: 5703 QDFTTSVENLFRFLTDTSHLLSA-VKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALT 5761
Query: 2040 ID-GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
++ G++LL + ++ +++ L + W+ + + + S + W + + ++
Sbjct: 5762 LEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKE 5821
Query: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158
L+ L + L + L + L E++ + Q + T++A +
Sbjct: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELE-QSLASWTQNLKELQTMKADLTRHVL 5880
Query: 2159 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKK 2218
+ L+ ++ + +W+ +R+ +K+++ L W + + L +
Sbjct: 5881 VED--VMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMEN 5938
Query: 2219 KLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERV 2278
K+ Q+ EE+ E+++ K+ + ++++ QL + D L + + +++++
Sbjct: 5939 KVLQTADISIEEM-IEKLQ-KDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKL 5996
Query: 2279 ELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIE 2336
+ +W+ L + R +++ E + L WL ++ES++S+ D+ +
Sbjct: 5997 NKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDD 6056
Query: 2337 EMIEK-------LKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDR 2389
+ I+K L++D ++ A + + ++E++ I+ ++ R
Sbjct: 6057 QEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRR 6116
Query: 2390 WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKP----IVYDSCNSEE 2445
W+++ + R K++ET Q+ + S WL E A P ++Y S E
Sbjct: 6117 WRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE- 6175
Query: 2446 IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWR 2505
L + QR I + T + + L + TD ++Q ++RW
Sbjct: 6176 ----LKRFEAFQRQIHERLTQLELINKQYRRLARE---NRTDT-ASRLKQMVHEGNQRWD 6227
Query: 2506 NICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIYTVAK 2560
N+ + ++ R + F + FE +S +E + + A
Sbjct: 6228 NL-------QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD 6280
Query: 2561 EELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV 2620
+++++ FQ+++ +++ + +L +++ A ++ + E ++ + RV
Sbjct: 6281 DKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV 6340
Query: 2621 TSILRRL 2627
+ RRL
Sbjct: 6341 SRFHRRL 6347
Score = 120 bits (300), Expect = 3e-26
Identities = 659/3526 (18%), Positives = 1282/3526 (36%), Gaps = 572/3526 (16%)
Query: 6 AVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILK 65
A++K E+N + K+ + +L Q + R + LN A +L Y E + ++
Sbjct: 3211 AIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVE 3270
Query: 66 WIE--KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCT 123
I +A ++ + N L E + Q EE + + ++ +TEKL ++S
Sbjct: 3271 SITSLEAIIIPYRVDVGNPEESL-EMPLRKQ---EELESTVAHIQDLTEKLGMISSPEAK 3326
Query: 124 EKMSQQVAELGRETEELRQMIKIR-------LQNLQDAAKDMKKFEAELKKLQAALEQAQ 176
++ + EL + +++ K + L+N + K + L K++ L Q+
Sbjct: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSM 3386
Query: 177 ATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAA 236
++L P R +L E+L + L+S + S K ++ ++ LR+ + L
Sbjct: 3387 SSL--PLSYREAL-ERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIV 3443
Query: 237 LRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ 296
L E+ ++++AA +++E + L+Q + EIE + + N+Q
Sbjct: 3444 SALWEK----------WLSLLEAA----KEWEMWCEELKQEWKFVSEEIEREAIILDNLQ 3489
Query: 297 ELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD 356
E +IS+ +E A +E L+ C+ K +L + + + +
Sbjct: 3490 EELPEISKTKEAATT----EELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
Query: 357 GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 416
G + P+ M RC+ LL V + N E+ S A
Sbjct: 3546 GAVETVPAFQEITSMKE--RCNKLLQKVQK-------NKELVQTEIQERHSFTKEIIALK 3596
Query: 417 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL--QRSWETLKNV 474
N ++Q + Q A + HP S E E + K G L + E L+
Sbjct: 3597 N----FFQQTTTS-FQNMAFQDHPEKSEQFE------ELQSILKKGKLTFENIMEKLRIK 3645
Query: 475 ISEKQRTLYEALERQ-QKYQDSLQSISTKMEAIELKLSES-------------------- 513
SE + +E Q ++ + +L+ I K+ LK S S
Sbjct: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
Query: 514 -PEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLT 572
+ ++ E + + DE+ + ++NEL S V + E DP + L
Sbjct: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSE-----VQDIVEQDPGQAQEWMDNLM 3760
Query: 573 VLAERMSTIRMKAS------GKRQLLEEKLNDQLE--EQRQEQALQRYRCEADELDSWLL 624
+ ++ + +A K + E+ +D L+ E E AD L
Sbjct: 3761 IPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTL 3820
Query: 625 STKA-TLDTALSPPKEPMD-MEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGK--- 679
S A T+ AL ++ + + + MD +++ + E + S + N+ L+ K
Sbjct: 3821 SHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIME 3880
Query: 680 -----AHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDL------ 728
D+ + +++ ++ + +++ L K++ + + +V L
Sbjct: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPM 3940
Query: 729 --TATQSPGVQEWLAQARTTWT-----QQRQSSLQQQKELEQELAEQKSLLRSVASR--- 778
T + Q L +T Q+ LQ K LE EQ LL+ V +
Sbjct: 3941 KKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNE 4000
Query: 779 -GEEI-----LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ---MRMKWESLHQE 829
EEI ++ + +A+ S + PD + ++GE E Q + + E L +
Sbjct: 4001 WDEEIENLKQILNNYSAQFSLE-HMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD 4059
Query: 830 FSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS-------AVTSLLDGL 882
L L+QEQE V R L V +G V +D S S L +
Sbjct: 4060 LKATVLNLHQHLKQEQEGVERDR----LPAVTSEEGGVAERDASERKLNRRGSMSYLAAV 4115
Query: 883 NQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDD---VEERLFVATALLPEETETC 939
+ EE S +S ++ Q S +S W D E+R ++ + +E
Sbjct: 4116 EEEVEESSVKSDNGDEKAEPSPQ------SWSSLWKHDKDMEEDRASSSSGTIVQEAYGK 4169
Query: 940 LFNQ-----EILAKDI--KEMSEEMDKNKNLFSQAF--PENGDNRDVIEDTLGCLLGRLS 990
+ +IL D E E N + P D D D G L R+
Sbjct: 4170 ISTSDNSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLD-SSDAQGGLEPRVE 4228
Query: 991 LLDSVVNQRCHQMKERLQQILNFQNDLKVLF---TSLADNKYIILQKLANV------FEQ 1041
+ H K ++ ++ + V T AD + ++ Q+L E
Sbjct: 4229 KTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEH 4288
Query: 1042 PVAEQIEAIQQ---AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMII 1098
VA +E + ++G + +A + LK + K +E+ M LQ+ + E
Sbjct: 4289 KVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMM----LQEKHSEDQHPT 4344
Query: 1099 GSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYF 1158
++S + +++ ALQ + + + IV+ + + + D ++
Sbjct: 4345 ILKKSS-------EPEHQEALQPV----------NLSELESIVTERPQFSRQKDFQQQQV 4387
Query: 1159 QGLESHMILTETLFRKIISFAVQK----ETQFHTELMAQASAVLKRAHKRGVELEYILET 1214
L+ + + F K I F +K Q + ++SA + + + IL
Sbjct: 4388 LELKP---MEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSP 4444
Query: 1215 WSHLDEDQQELSRQLEVVESSIPSVGLVEENEDR---LIDRITLYQHLKSSLNEYQPKLY 1271
+ Q L +L + +P LVE ++ +T+Y + E +
Sbjct: 4445 QGQNGDKWQYLHHELS-SKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTT 4503
Query: 1272 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNK-------MSKELHRLETILKHWTRY 1324
Q+ D + S+L++Q N E +++ K +S+ L +E +L+ Y
Sbjct: 4504 QLED------LRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLY 4557
Query: 1325 QSE-SADLIHWLQSAKDRLEFWTQ---------QSVTVPQE----LEMVRDHLNAFLEFS 1370
+ + S +H+ A + + + +++T P E L D+L LE +
Sbjct: 4558 REDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHT 4617
Query: 1371 KEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 1430
+ A + +S L G R + ++E+ R+ HQL
Sbjct: 4618 Q---AAAVCRSKSLKAGLDYNR-------SYQNEIKRL-----------------YHQL- 4649
Query: 1431 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT 1490
+ S SL +++ N I +++ E LQK + +++
Sbjct: 4650 ------------IKSKTSLQQSL---------NEISGQSVAEQLQKADAYTVEL------ 4682
Query: 1491 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLES-WS 1549
++ ES+ + D E+L L + +++ LE +L+S W
Sbjct: 4683 -------------ENAESRVAKLRDEGERLH--------LPYALLQEVYKLEDVLDSMWG 4721
Query: 1550 EYENNVQCLKTWFETQEKR------LKQQHRIGDQASVQNALKDCQD---LEDLIKAKEK 1600
L + F T+ ++ + + +IG + LK + L+ I+ +
Sbjct: 4722 MLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKV 4781
Query: 1601 EVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN-------LDHMVGQLKILLKSVL 1653
+K+ + + LIQ + I+ S L+ WA L+ Q + L+S+L
Sbjct: 4782 FFQKLVAD-MLLIQAYS---AKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
Query: 1654 DQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQK 1713
+W + + L +L L+ + E + ++ Q ++ ++ + L +
Sbjct: 4838 QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ 4897
Query: 1714 FGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSK 1773
+ QL+ P E L+E +W +L ++I +L +ALL+ Y S
Sbjct: 4898 TLNEGKQLVASVSCPELEGQIAKLEE---QWLSLNKKIDHELHRLQALLKHLLSYNRDSD 4954
Query: 1774 QCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 1833
Q ++ + N + + N D + + I + + K + + +G Q
Sbjct: 4955 QLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ 5014
Query: 1834 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 1893
L + A+ +++ Q L L Q L ++ K++ + +W+
Sbjct: 5015 LLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMN 5073
Query: 1894 EAEEILQGQDPSHS-SDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIK 1952
E +D HS S S ++ +++ K ++ +D +N+ +L D E K
Sbjct: 5074 NVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESK 5133
Query: 1953 RMQ---------NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL 2003
R + +NR W + + L+ L K + +L E++L
Sbjct: 5134 RYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERL 5193
Query: 2004 AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRL---------LEQGQVDDR 2054
L++ + Q + Q I + + I + L LE G V
Sbjct: 5194 KT---------LQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLL 5244
Query: 2055 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 2114
++ ++ L + V+ + Q + + S +++W+ Y ++ +++ + Y M
Sbjct: 5245 EDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYC-MEHS 5303
Query: 2115 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEI 2174
V + L+ R + +Q + +GS+ E +L S AE ++ +
Sbjct: 5304 KPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAE-IIEEKCQNT 5362
Query: 2175 QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK------LSQSLPDHH 2228
++W + + +Q +K LL+ W+ ++ +L+ + K +S S +
Sbjct: 5363 HKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLA 5422
Query: 2229 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEEL 2288
E L KEL++ V + Q S + D L + +L + LQR
Sbjct: 5423 EILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQR----- 5477
Query: 2289 CHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE 2348
+ + + + NE+ + K+ L ++ + EE +++L + +E
Sbjct: 5478 ---AAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHE-----EENLDRLHQQEKE 5529
Query: 2349 EIAIAQENKIQLQQMG---ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKL 2404
+ + L E L + S + S++ K L +N +W + A +++
Sbjct: 5530 NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQW---IRATATALERC 5586
Query: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS-EEIQRKLNEQQELQRDIEKH 2463
E L + +K + W+ +E ++ + + D NS E+ + + L+ ++ +
Sbjct: 5587 SE-LQGIGLNEKFLYCCEKWIQLLE-KIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
Query: 2464 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 2523
T S + LL D + + I + ++ D RW+N +R+ ++ R
Sbjct: 5645 QTIADSYVTQSLQLL---DTTEIENRPEFITEFSKLTD-RWQNAVQGVRQRKGDVDGLVR 5700
Query: 2524 LWQ----------KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV 2573
WQ +FL D S +K ER + + + S +I+ + +E+ FQR+
Sbjct: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRS-LIHELKNKEIH----FQRRR 5755
Query: 2574 HECLTQLELINKQY------------RRLA--RENRTDSACSLKQMVHEGN---QRWDNL 2616
C LE K RR++ +++ D L +M+ + + WD
Sbjct: 5756 TTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQC 5815
Query: 2617 QKRVTSILRRLKHFIGQREE---------------FETARDSILVW------LTEMDLQL 2655
+K++ + RL+ Q E+ + S+ W L M L
Sbjct: 5816 EKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADL 5875
Query: 2656 TNIEHFSECDVQAKIKQLKAFQQE-------ISLNHNKIEQIIAQGEQLIEKSEPLDAAI 2708
T H DV +Q++ ++ +++ +IE + EK++ L A +
Sbjct: 5876 T--RHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
Query: 2709 --------------IEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDE---HDLSDREL 2751
IEE +++L++ C E + + + ++L D+ R
Sbjct: 5934 VQMENKVLQTADISIEEMIEKLQKDCME---EINLFSENKLQLKQMGDQLIKASNKSRAA 5990
Query: 2752 ELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDH 2811
E++D + W D + S + + Q L S T + L
Sbjct: 5991 EIDDKLNKINDRW-QHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPV 6049
Query: 2812 DYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSA-LESQIRQLGKALDDSR 2870
YD+ D E A E ++ Q D + HSA +ES L DS
Sbjct: 6050 VYDVCDDQEIQKRLA---EQQDLQRDIE-----------QHSAGVESVFNICDVLLHDSD 6095
Query: 2871 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 2930
+TE S T LD ++ + E I+ RL K ++ +
Sbjct: 6096 ACANETE--CDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDW-- 6151
Query: 2931 LHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQL 2990
L S E +TA + E+L A K+ L++++ F ++ E+L
Sbjct: 6152 LKSAE-RTAACPNSSEVLYTSA-------KEELKRFEAFQRQIH-------------ERL 6190
Query: 2991 QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-DLQDRLS 3049
+LEL I Q ++L ++E+R D RL
Sbjct: 6191 TQLEL------INKQYRRL----------------------------ARENRTDTASRLK 6216
Query: 3050 QM----NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 3105
QM N RWD + + L+ Q + F +L+ L +D + + S
Sbjct: 6217 QMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHF-S 6275
Query: 3106 NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNR 3165
DA+ D +QL + E+ + ++ L QL+ +E D + ++++ +
Sbjct: 6276 ESDAD---DKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY 6332
Query: 3166 LKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRG 3225
+ + VSR + L +++ S + E R +P+
Sbjct: 6333 CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGESEEPSSPQS 6392
Query: 3226 KCSLSQPGPSVSS--------------PHSRSTKGGSDSSLSEPGP 3257
C L PG S H+ G S E GP
Sbjct: 6393 LCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGP 6438
Score = 92.0 bits (227), Expect = 9e-18
Identities = 369/2091 (17%), Positives = 813/2091 (38%), Gaps = 317/2091 (15%)
Query: 26 GKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ 85
G+ TEL Q + + + + Q + L+EY + E+ +++ T
Sbjct: 1973 GEKTELFCQALARKREQFESVAQLNNSLKEYG--------FTEEEEIIMEATC------- 2017
Query: 86 LREQYILHQTLLEESKEIDSELEAMTEKLQYLTS-----VYCTEKMSQQVAELGRETEEL 140
L ++Y QTLL + EI+ E + + + Q ++ +++ + + L + E
Sbjct: 2018 LMDRY---QTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLN--SSEG 2072
Query: 141 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS---------LKE 191
+ ++ R+Q +++ + +A ++ + E ++A L + +S
Sbjct: 2073 KMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAST 2132
Query: 192 QLSHRQHLLSEMES--------------LKPKVQAVQLCQSALRIPEDVVASLPLCHAAL 237
LSH++ LL E E LK K +A Q L ++ A L + L
Sbjct: 2133 YLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGL---QEKKAQLKIYKKFL 2189
Query: 238 RLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQE 297
+ ++ + L Q N + E+ ++ L E ++++D ++Q
Sbjct: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQD------SVQN 2243
Query: 298 LQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMK-AKHATMLLTVTEVEGLAEGTEDLD 356
L + H+ YQ + LN+ + + + + VE + ++L+
Sbjct: 2244 LDGHVREHDS-------YQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELE 2296
Query: 357 GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 416
L ++ + + T G++ +I S C+ + N AS
Sbjct: 2297 NRLSLQDGTLKKILALAKS-----VKQNTSSVGQKIIKDDIKSLQ-CKQKD-LENRLASA 2349
Query: 417 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVIS 476
Q++ E K ST +F PG E AT+ + + + ++ +
Sbjct: 2350 KQEM--------ECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEE 2401
Query: 477 EKQRTLYEALERQQKYQDSLQSI-STKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL 535
+ + A+E Q SL + S K E K++E ++Q L + +
Sbjct: 2402 DWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNE------------LQNQPLELDTM 2449
Query: 536 MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK 595
+ +++ E++ L +L ++ P EQ + A + I A LL+
Sbjct: 2450 LRNEQLEEIEK-LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQAL 2508
Query: 596 LNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLV 655
+ + ++ Q L+ ++ ++S S KA L S P+D L + +
Sbjct: 2509 ITLKKNKESQYCVLRDFQEYLAAVES---SMKALLTDKESLKVGPLDSVTYLDKIKKFIA 2565
Query: 656 EIEQKVVALSELSVHNENLLLEGKAHTKD-EAEQLAGKLRRLKGSLLELQRALHDKQLNM 714
IE++ +L L + ENL H D + + L ++++L+ ++++ + K
Sbjct: 2566 SIEKEKDSLGNLKIKWENL----SNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY--- 2618
Query: 715 QGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRS 774
+Q+ E D T Q QQ+Q LQ + + +E A +S+
Sbjct: 2619 ---SQQVVEYDEFTTLMNK-------VQDTEISLQQQQQHLQLRLKSPEERAGNQSM--- 2665
Query: 775 VASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED---QMRMKWES---LHQ 828
+A + +H + G A ++ + + E EK + ED ++ +WE+ LH
Sbjct: 2666 IALTTDLQATKHGFSVLKGQA----ELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
Query: 829 EFSTKQKLLQNVLEQEQEQVLYSRP--NRLLSGVPLYKGDVPTQ-------------DKS 873
E + K ++ + +E +L+++ L +PL D+ +Q +
Sbjct: 2722 EAENQIKKC-DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQ 2780
Query: 874 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDD-----VEER---- 924
+V SL + + +++ G ++ + Y + ST +EER
Sbjct: 2781 SVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFF 2840
Query: 925 -LFVATALLPEETETCLFNQ-----------------EILAKDIKEMSEEMDKNKNLFSQ 966
+ L+ +E+ET + + E K+++E+ + + +
Sbjct: 2841 AIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTN 2900
Query: 967 AFPE-NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLA 1025
+ E N R +ED L L R + + + C++++ K+ F
Sbjct: 2901 IYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH------------KIKFCRQF 2948
Query: 1026 DNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS 1085
K LQ+ A+ ++ ++ Q+ G+KE E+ D+L + + ++
Sbjct: 2949 HEKTSALQEEADSIQR---NELLLNQEVNKGVKE------EIYNLKDRLTAIKCCILQVL 2999
Query: 1086 KLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE 1145
KL+ ++D + + S L+Q T + E+ L++ L+T +E+ G + ++S
Sbjct: 3000 KLKKVFDYIG--LNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEE-HGKYQALLSKMR 3056
Query: 1146 EIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRG 1205
I + K E + L +I+S ++K E++ + + +
Sbjct: 3057 AIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNE--NKTFDDS 3114
Query: 1206 VELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNE 1265
+ + IL+ + + +E + +V+++ + + E +E D++ H+ LN+
Sbjct: 3115 FKEKEILQ----IKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHV---LNQ 3167
Query: 1266 YQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 1325
+ +L Q LLI++ ++++ + E + + + I K
Sbjct: 3168 IKSQLQQ------PLLINLEIKHIQNEKDNC-EAFQEQVWAEMCSIKAVTAIEKQREENS 3220
Query: 1326 SESADLIHWLQSAKDRLEFWTQQSVTV-PQELEMVRDHLNAFLE-FSKEVDAQSSLKSSV 1383
SE++D+ L+ +D L+ S+ + L ++L + E ++ V++ +SL++ +
Sbjct: 3221 SEASDVETKLREFED-LQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAII 3279
Query: 1384 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQM-----DKLPSRH 1438
+ +VD L + +L + + +Q+ +L M KL ++
Sbjct: 3280 IP--------YRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQY 3331
Query: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ E++S S M+ + E + YL+ YK C + + + ++
Sbjct: 3332 TLQELVSKNSAMKEAFKAQETEAE---------RYLENYK-------CYRKMEEDIYTNL 3375
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLE-----GLLESWSEYEN 1553
++ + +S S + E L + +S ++ L++ K +L++ LL +
Sbjct: 3376 SKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND 3435
Query: 1554 NVQCLKTWFETQEKRLKQQHRIGDQASVQNALKD----CQDLEDLIKAKEKEVEKIE--- 1606
+ LK EK L S+ A K+ C++L+ K +E+E+
Sbjct: 3436 GICLLKIVSALWEKWL----------SLLEAAKEWEMWCEELKQEWKFVSEEIEREAIIL 3485
Query: 1607 ---QNGLALIQNKKEDVSSIVMSTLRE-LGQTWANLDHMVGQLKILLKSVLD----QWSS 1658
Q L I KE ++ +S L + L Q N++ L +LL+ + SS
Sbjct: 3486 DNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
Query: 1659 HKV----AFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKF 1714
V AF +I S L + + + E VQ ++ + ++ + Q+
Sbjct: 3546 GAVETVPAFQEITSMKERCNKLLQK---VQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602
Query: 1715 GSITNQLLKECHPPVT---ETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 1771
+ + + HP + E L + LK+ + + N++E++ +++ S+ + +
Sbjct: 3603 TTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKL--RIKYSEMYTIVPAEIESQ 3660
Query: 1772 SKQCASTVQQQEDR-TNELLKA----ATNKDIAD-----DEVATWIQDCNDLLKGLGTVK 1821
++C ++ +++ +NE+LK+ A + I + V +Q + ++ ++
Sbjct: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
Query: 1822 DSLFFLHELGEQLKQQVDASAASAIQSD-----------QLSLSQHLCALEQALCKQQTS 1870
++ +L ++D+ ++ D + Q+ ++A C+ +
Sbjct: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECR-TSQ 3779
Query: 1871 LQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP-----SHSSDLSTIQERMEELKGQML 1925
L + E ++ L++ EAWI +L + S ST+Q +E+ + +
Sbjct: 3780 LNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHN 3839
Query: 1926 KFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 1976
S+ DL+ L+ + D+ + +Q L+ + + + E ++Q
Sbjct: 3840 LLHSIFMDLEDLSIIFE----TDELTQSIQELSNQVTALQQKIMESLPQIQ 3886
Score = 90.9 bits (224), Expect = 2e-17
Identities = 420/2300 (18%), Positives = 883/2300 (38%), Gaps = 390/2300 (16%)
Query: 1106 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 1161
NQN+ ++E+ ++ TGQ K+A D + ++ E E + +LD+
Sbjct: 713 NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
Query: 1162 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 1218
+T + + + K + F ELMA++ +L+ + +++L T
Sbjct: 762 ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
Query: 1219 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 1278
+ + Q+ VV+ L + + D +D + + L Y + Q+L +
Sbjct: 815 KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
Query: 1279 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 1333
S +L S+ + +SNT ++K L +E + + T + +S D+
Sbjct: 873 ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
Query: 1334 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 1393
+S L + QQ + + E + D++ L+ K+++ + L +
Sbjct: 925 KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
Query: 1394 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 1453
++ T L E S+ L + E L +L ++LPS+ + EV L+++
Sbjct: 968 RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
Query: 1454 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 1513
QK E +K + IH LQ G N +T + +S
Sbjct: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
Query: 1514 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 1559
T+ A + +L+ L E I + LLE + Y +NN +
Sbjct: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
Query: 1560 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 1619
+ F ++E R + +Q L D Q +++ A+ KE E I + + K+
Sbjct: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
Query: 1620 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 1678
TL+E + L+ + L+ L+ VL K + S L + ++
Sbjct: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
Query: 1679 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 1738
F L+ +A ++ +L+N+QD + KQ + N +LKE HP + N +
Sbjct: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
Query: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 1798
+ ++ + + + KAL +D+ + E T+ +A++ +
Sbjct: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
Query: 1799 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 1855
A + T + L+K D + ++ + ++ D S + + + + LS+
Sbjct: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
Query: 1856 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 1908
H +++ ++ L+A + K+++ +++ I + + +DP+
Sbjct: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
Query: 1909 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 1968
L + + ++E + + MA L + G +N ++ + L + + ++
Sbjct: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
Query: 1969 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 2025
E+ ++ L Q+Q F ++ + L+Q E+ + + + +Y ++L ++ E+ +
Sbjct: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
Query: 2026 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 2082
E ++ ++ + + Q L + + + F + ++ ++W + + + +
Sbjct: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
Query: 2083 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 2142
+ W + + + +W + + L Q T D + KE++ + +Q
Sbjct: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
Query: 2143 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 2196
+ + + L S LQ + I K + L + A L
Sbjct: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
Query: 2197 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 2252
+D ++ + I + L+ S + EE+ + ++ K LEN +G T +L
Sbjct: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
Query: 2253 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 2312
++L +++S + N + +LQ + +L + + N+W FS
Sbjct: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
Query: 2313 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 2367
L E E+K S +E+ ++KL E + +KI+ L+ + + L
Sbjct: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
Query: 2368 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 2424
KA + S + E++L K+ + AR K+L+++L + +L + +LR W
Sbjct: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
Query: 2425 LAHIE------------------------------------------SELAKPIVYDSCN 2442
L + E +E + I+ +C
Sbjct: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
Query: 2443 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 2502
+ Q L + E++ + + T S +L ++H + + L+
Sbjct: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
Query: 2503 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 2551
R + I + E +IE + L QK L D S W + + + S
Sbjct: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
Query: 2552 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 2594
G Y +KE ELKK + A Q + E QL++ K ++
Sbjct: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
Query: 2595 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641
D LK++ +GN + W ++ S+L++L+ + +
Sbjct: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
Query: 2642 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 2692
DS V +T+++ L N E S D V+ K+++L+ + +SL +++I+A
Sbjct: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
Query: 2693 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 2735
+ + + + + II++++ L+ C + +R +K
Sbjct: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
Query: 2736 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 2792
+ LP E SD + ++SAA+ L W + + DS + S LSL+ + +++
Sbjct: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
Query: 2793 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 2841
R + + PLE D L LE+ + P E E + +
Sbjct: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
Query: 2842 LRGAVGLSGDH-SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 2900
+ +G S H L + L K + ++ + + + + L T +
Sbjct: 2490 VLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG 2549
Query: 2901 LGECSSSIDSVKRLEHKLKEEEESLPGF------VNLHST-------ETQTAGVIDRWEL 2947
+ + +D +K+ +++E++SL ++ H T E+Q + WE
Sbjct: 2550 PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQ 2609
Query: 2948 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 3007
++ Q K Q + ++ +F + +N + DTE L+Q Q+ LQ+
Sbjct: 2610 VEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ----------HLQL- 2651
Query: 3008 KLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKESRDLQDRLSQMNG 3053
+LK ++ ++ I L+ +L + + QA+ KE ++L+D ++ +
Sbjct: 2652 RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKK 2711
Query: 3054 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ 3113
+W+ LE ++ + +C ++M +L +N+ N +P+ L +IL
Sbjct: 2712 QWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSIPL---LPDDILS 2763
Query: 3114 DHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKEKVHVIGNRLKLL 3169
K ++ H+ +L Q V SL + L EG+D E + N+ ++L
Sbjct: 2764 QIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLR---NQYQML 2818
Query: 3170 LKEVSRHIKELEKLLDVSSS 3189
+ + ++ ++LE L+ S+
Sbjct: 2819 VLKSTQRSQQLEFKLEERSN 2838
Score = 85.1 bits (209), Expect = 1e-15
Identities = 363/1901 (19%), Positives = 732/1901 (38%), Gaps = 302/1901 (15%)
Query: 756 QQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLS--QELG---MEG 810
+ QKELE + + LL S GE ++ +H A + L +EL E
Sbjct: 852 ESQKELESYMMRAQQLLGQRESPGE-LISKHKEALIISNTKSLAKYLKAVEELKNNVTED 910
Query: 811 EKSSAEDQMR---MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDV 867
K S E++ R KWESLH E S + L+ +E+ +L + + +
Sbjct: 911 IKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEK----------GKLSDNILKLEKQI 960
Query: 868 PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLE--QKLYDGVSATST------WLD 919
+ K GL + E S+ G + + H+E ++L + + + + L
Sbjct: 961 NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020
Query: 920 DVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR---- 975
D E+++ E T +K+ ++ ++ + S+A DN+
Sbjct: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080
Query: 976 DVIEDTLGCLLGRL-------SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNK 1028
+E T+ L + S+++ + + + ER + +L L +NK
Sbjct: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLER------YDTYRDILEHHLQNNK 1134
Query: 1029 YIILQKLANVFE------QPVAEQIEAIQQAEDG-LKEFDAGIIELKRRGDKLQVEQP-S 1080
+ I ++ + Q ++ I+ D KEF+ II LK +++P
Sbjct: 1135 FRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFE--IISLKLENHVNDIKKPFV 1192
Query: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
++E L++ EL M + +R L L L E+ A LL G +
Sbjct: 1193 IKERDTLKERERELQMTLNTRMESLETALRLVLPVEK-----ASLLLCGSD--------- 1238
Query: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKI--ISFAVQKETQFHTELMAQASAVL 1198
L HK QG H+I + +++ + I ++ K+ + L + VL
Sbjct: 1239 ----------LPLHKMAIQGF--HLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVL 1286
Query: 1199 KRAH------KRGVELEY--ILETWSHLDEDQQELSRQLEVVESSIPSVGL-VEENEDRL 1249
K H + + L+Y E +H + ++ + LE +S+ + L E D
Sbjct: 1287 KELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLS 1346
Query: 1250 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRL-----LISISCSDLESQLNQLGECWLSNT 1304
+ Q ++ + +++ + D K L ++ +S D E + E L
Sbjct: 1347 ASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAF 1406
Query: 1305 NKMSKELHRLETILKHWTRYQS-------ESADLIHWLQSAKDRLEFWTQQSVTVPQELE 1357
+ E H + + +T ++ +L+ +Q + ++ + TVP
Sbjct: 1407 SIKLSETHGY-GVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVP---- 1461
Query: 1358 MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQW----- 1412
V+ + + K +D K + N L K T+ + W
Sbjct: 1462 AVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKA 1521
Query: 1413 --TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG---- 1466
T+ L V E L Q Q K I + S ISL + + K +N+K I
Sbjct: 1522 LVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGK--ENLKKRIAEIEI 1579
Query: 1467 -YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESK--------RSDKT-DF 1516
+ +E+L+ KI+ CK L + + E+ ++KT D+
Sbjct: 1580 VKEEFNEHLEVVD--KINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDY 1637
Query: 1517 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 1576
E LG W +K+ L+ +++ W+E L E +RLK++ ++
Sbjct: 1638 YENLGRALALW--------DKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVH 1689
Query: 1577 DQASVQNALKDCQDLEDLIKAKE--KEVEKIEQNGLALIQNKKEDVSS---------IVM 1625
+Q + + + + +++ L+++ E E++ +E + I NK E V +
Sbjct: 1690 EQKTSEFS-RRVAEIQFLLQSSEIPLELQVMESS----ILNKMEHVQKCLTGESNCHALS 1744
Query: 1626 STLRELGQTWANLDHMVGQLKILLKSVLDQWSSH-KVAFDKINSYLMEARYSL----SRF 1680
+ EL + +G + LLK++ S ++I +++ ++S+ ++
Sbjct: 1745 GSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQI 1804
Query: 1681 RLLTGSLEAVQVQVDNLQN--------LQDDLEK----QERSLQKFGSITNQLLKECHPP 1728
LT L ++ Q +++ + LQD K Q ++ + S LKEC
Sbjct: 1805 GCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFES 1864
Query: 1729 VTETLTNTLKEVNMRWNNLLEEIAEQLQSSK-----ALLQLWQRY--KDYSKQCASTV-- 1779
+ T K V + L + + + ++SK ++L+ +++ K + K+ S +
Sbjct: 1865 -----SETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVG 1919
Query: 1780 QQQEDRTNELLKAATNKDIAD--DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQ 1837
Q+ E E + A K++ D ++ D +L K L ++ + E GE+ +
Sbjct: 1920 QEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
Query: 1838 VDASAASAIQSDQL-----SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 1892
A A Q + + SL ++ E+ + + T L Y+T + L +E
Sbjct: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMD---RYQTLLRQLSEIE--- 2033
Query: 1893 VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSS------MAPDLDRLNELGYRLPL 1946
E +++L +D S + + ++E+K ++ +S + + ++ E+ P
Sbjct: 2034 -EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPE 2092
Query: 1947 NDKEI----------------KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990
D I K + +++ W + S + LL+ + +L+ E
Sbjct: 2093 GDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKE 2152
Query: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG- 2049
L++ ++K E QH L++++A + + Q L S++ + L QG
Sbjct: 2153 DLRLMLIELKKK--QEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLL---KELKSQGN 2207
Query: 2050 ---QVDDRDEFNLKLTL-LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE 2105
+ F+ + L + + + ++++ Q +D +R+ Y+ L L
Sbjct: 2208 YLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDN 2267
Query: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAG--KQLLLSADSGA 2163
S +S P+ D++ +EK+ Q+ L+++ G K++L A S
Sbjct: 2268 FSKEFVS-FSDKPV---------DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVK 2317
Query: 2164 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223
+ I++ KS + ++ + +LA ++ E C I L+ R+ +KK +
Sbjct: 2318 QNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI---LKSKRSTEKKGKFT 2374
Query: 2224 LPDHHEELHAEQMRCKELENAVGSWTDD--LTQLSLLKDTLSAYISADDISIL-----NE 2276
LP ++ ++ + AV +D + + S ++ +S +S + +
Sbjct: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
Query: 2277 RVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK-----ELCEWLTQMESKV---- 2327
+V LQ Q EL LR +Q+ E + K E E L + E+
Sbjct: 2435 KVNELQNQPLEL--DTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLH 2492
Query: 2328 -----SQNGDILIEEMIEKLK---------KDYQEEIAIAQENKIQLQQMGERLAKASHE 2373
+Q+ D L++ +I K +D+QE +A + + L E L +
Sbjct: 2493 NIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLD 2552
Query: 2374 SKA---------SEIEYK---LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 2421
S + IE + LG + +W++L + + KKL E+ ++QL+
Sbjct: 2553 SVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLES--QIKQLEHG---- 2606
Query: 2422 RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK 2462
W +E ++ K +E +N+ Q+ + +++
Sbjct: 2607 --W-EQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQ 2644
Score = 73.9 bits (180), Expect = 2e-12
Identities = 322/1774 (18%), Positives = 692/1774 (39%), Gaps = 283/1774 (15%)
Query: 1451 ENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKR 1510
EN++ + + GY E+ ++ K + I F N +L+ + QDV+S+
Sbjct: 1400 ENLLDAFSIKLSETHGYGVQEEFTEENKLLEACI--------FKNNELLK-NIQDVQSQI 1450
Query: 1511 SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQ----CLKTWFETQE 1566
S ++G + + ++ I+L + +L+ + E + ++Q L + + +E
Sbjct: 1451 S-------KIGLKDPTVPAVKHRKKSLIRL-DKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
Query: 1567 KRLKQQHRI------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620
K + QQ + +A V L+ C + +L+K + + + LIQ K+E V
Sbjct: 1503 KTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLK----QYQNFKSILTTLIQ-KEESV 1557
Query: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680
S+ S + + NL + +++I V ++++ H DKIN ++ L++
Sbjct: 1558 ISLQASYMGK-----ENLKKRIAEIEI----VKEEFNEHLEVVDKINQVCKNLQFYLNKM 1608
Query: 1681 RLLTGSL--EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 1738
+ + + VD ++ + E +L + ++ ++L + E L+
Sbjct: 1609 KTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFN-LKNVIDEWTEKALQ 1667
Query: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAST--VQQQEDRTNELL---KAA 1793
++ + + L EE E+L+ + + Q+ ++S++ A + Q + EL +
Sbjct: 1668 KMEL--HQLTEEDRERLKEELQVHE--QKTSEFSRRVAEIQFLLQSSEIPLELQVMESSI 1723
Query: 1794 TNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA---SAIQSDQ 1850
NK + T +C+ L +++ L +Q K Q+ + + + SD
Sbjct: 1724 LNKMEHVQKCLTGESNCHALSGSTAELREDL-------DQAKTQIGMTESLLKALSPSDS 1776
Query: 1851 LSLSQHLCALEQALCKQQTSL-----QAGVLDYET--FAKSLEALEAWIVEAEEILQGQD 1903
L + L ++Q + +Q+ S+ Q G L E K E++ + +LQ
Sbjct: 1777 LEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHF 1836
Query: 1904 PSHSSD--------LSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQ 1955
+D S I+ ++E S+ L +L++ L + +IK++
Sbjct: 1837 SKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDF-LTLEGRNSKIKQVD 1895
Query: 1956 NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLL 2015
++ +H + +L S+L+ + LEK ME + Q K E+ + Q LL
Sbjct: 1896 SVLKH--VKKHLPKAHVKELISWLVGQEFELEK----MESICQARAK---ELEDSLQQLL 1946
Query: 2016 EQQRAH------------------------ELFQAEMFSRQQILHSIIIDGQRLLEQGQV 2051
Q H ELF + +++ S+ L E G
Sbjct: 1947 RLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFT 2006
Query: 2052 DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPM 2111
++ +E ++ T L +++Q ++R+ + + Q + ++A + W+ E+ M
Sbjct: 2007 EE-EEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLM 2065
Query: 2112 ---SGLGSVPIPLQQARTLFDEVQ-FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAAL 2167
S G +P+ + +Q KE + L+ +G + + ++ A+S +
Sbjct: 2066 VLNSSEGKMPLE--------ERIQKIKEIILLKPEGDARI-----ETIMKQAESSEAPLV 2112
Query: 2168 QAELAEIQEKWKS----ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223
Q L +I +W + AS L Q+K LL + EK + D L KKK
Sbjct: 2113 QKTLTDISNQWDNTLHLASTYLSHQEK----LLLEGEKYLQSKEDLRLMLIELKKKQEAG 2168
Query: 2224 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 2283
H L ++ + K + + DLT SLLK+ S + + + +
Sbjct: 2169 FALQHG-LQEKKAQLKIYKKFLKK-AQDLT--SLLKELKS---QGNYLLECTKNPSFSEE 2221
Query: 2284 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 2343
W E+ H QQ+ + + ++ +T + + + D +E +
Sbjct: 2222 PWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL----DNFSKEFVSFSD 2277
Query: 2344 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 2403
K + IA E K+Q K E+E +L + + +L L K
Sbjct: 2278 KPVDQ---IAVEEKLQ---------------KLQELENRLSLQDGTLKKILAL----AKS 2315
Query: 2404 LKETLVAVQQ--LDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 2461
+K+ +V Q + ++ SL+ +E+ LA +E++ LN + +R E
Sbjct: 2316 VKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASA-------KQEMECCLNSILKSKRSTE 2368
Query: 2462 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQ--ATRNLDRRWR----NICAMSMERR 2515
K + L + AT +S Q+ A L+ W + M+M ++
Sbjct: 2369 KKG----------KFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQ 2418
Query: 2516 LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE 2575
L + + ED K +E ++ EE++K
Sbjct: 2419 LSLNAQ--------ESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKL--------- 2461
Query: 2576 CLTQLELINKQYRRLARE---NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIG 2632
TQLE + L + N+T++ + + Q DNL + + ++ + +
Sbjct: 2462 -YTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
Query: 2633 QREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKAFQQEISLNHNKIEQI 2690
+F+ + + + M LT+ E D + ++K F I + + +
Sbjct: 2521 VLRDFQ---EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
Query: 2691 IAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRE 2750
+ E L +D ++E ++ +L ++V ++++ + S +
Sbjct: 2578 KIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY---------------SQQV 2622
Query: 2751 LELEDSAALSDLHWHDRSADSLLS-PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEW 2809
+E ++ L + + D+ +S Q +L L L P ER+G + ++ +
Sbjct: 2623 VEYDEFTTLMN-----KVQDTEISLQQQQQHLQLRLKSP--EERAGNQSMIALTTDLQAT 2675
Query: 2810 DHDYD-LSRDLESAMSRALPSEDEEGQDDKDFYLRGA-VGLSGDHSALESQIRQLGKALD 2867
H + L E M R ++++ +D L+ L H E+QI++
Sbjct: 2676 KHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKC----- 2730
Query: 2868 DSRFQIQQT----ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV----KRLEHKLK 2919
D R ++++T +N++ P+ P L ++ +C + D + + +E +
Sbjct: 2731 DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIR---KCKVTHDGILARQQSVESLAE 2787
Query: 2920 EEEESLPGFVNLHSTETQTA--GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW 2977
E ++ +P ++ + +++++L ++ + +++ L++ F + +
Sbjct: 2788 EVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
Query: 2978 AWLGDTEEEL-----EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 3032
+ ++E + EL T+E K+L+E+ + + +I
Sbjct: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNI------ 2901
Query: 3033 FTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 3092
+ + + E L+D+L + R +R+ ++ ++ + C+ FHE + L ++
Sbjct: 2902 YEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADS 2961
Query: 3093 IDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 3126
I R NE++ L+ E+ + +++ +K L
Sbjct: 2962 IQR--NELL-----LNQEVNKGVKEEIYNLKDRL 2988
Score = 72.8 bits (177), Expect = 5e-12
Identities = 505/2870 (17%), Positives = 1040/2870 (36%), Gaps = 420/2870 (14%)
Query: 28 LTELHQQTIRQAENRLSK-------LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 80
L ELH + +N + K +N E+ + LE L + AK+ A
Sbjct: 1286 LKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDL 1345
Query: 81 NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRET--E 138
+++ Q TL ++KE E+ M +K ++L MS + AE G +T E
Sbjct: 1346 SASDT---QVAQENTLTVKNKE--GEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCE 1400
Query: 139 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQH 198
L I+L ++F E K L+A + + L + + Q
Sbjct: 1401 NLLDAFSIKLSETHGYGVQ-EEFTEENKLLEACIFKNNELL-----------KNIQDVQS 1448
Query: 199 LLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQH-------TAI 251
+S++ P V AV+ + +L + V+ LQE A+ L H T
Sbjct: 1449 QISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYE--EEKRHLQEMANSLPHFKDGREKTVN 1506
Query: 252 QQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQK 311
QQC Q VV +E + + + E Q R EL ++
Sbjct: 1507 QQC---QNTVVLWENTK------------------------ALVTECLEQCGRVLELLKQ 1539
Query: 312 IKGYQEQIASLNSKCK-MLTMKAKHA---TMLLTVTEVEGLAEGTEDLDGELLPTPSAHP 367
+ ++ + +L K + +++++A + + + E+E + E + H
Sbjct: 1540 YQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNE-----------HL 1588
Query: 368 SVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIA-YYQAL 426
VV C L + + E PP + + + + +N+ YY+ L
Sbjct: 1589 EVVDKINQVCKNLQFYLNKMKTFE-------EPPFEKEANIIVDRWLDINEKTEDYYENL 1641
Query: 427 SAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEAL 486
D K+ + E+ E L+ +L + R E LK + ++ E
Sbjct: 1642 GRALALWD--KLFNLKNVIDEWTEKALQKMELHQLTEEDR--ERLKEELQVHEQKTSEFS 1697
Query: 487 ERQQKYQDSLQS--ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINEL 544
R + Q LQS I +++ +E + E + + + AL L++++++
Sbjct: 1698 RRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQA 1757
Query: 545 --QSSLAEELVSESCEADPAE----------QLALQSTLTVLAERMSTIRMKASGKRQLL 592
Q + E L+ +D E Q+ Q +L E + +
Sbjct: 1758 KTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQ 1817
Query: 593 EEKLNDQLEEQR---QEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD 649
E ++D ++ Q+ + + + W + K L + +E +L
Sbjct: 1818 YESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQK 1877
Query: 650 CQNMLV------EIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 703
+ L +I+Q L + H KAH K+ L G+
Sbjct: 1878 LSDFLTLEGRNSKIKQVDSVLKHVKKHLP------KAHVKELISWLVGQ----------- 1920
Query: 704 QRALHDKQLNMQGTAQEKEESDVDLTATQSP--GVQEWLAQARTTWTQQRQSSLQQQKEL 761
+ L + Q A+E E+S L Q +++WL W + ++ +
Sbjct: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPG-EKTELF 1979
Query: 762 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRM 821
Q LA ++ SVA + +E G + E+++ M
Sbjct: 1980 CQALARKREQFESVAQLNNSL---------------------KEYGF-----TEEEEIIM 2013
Query: 822 KWESLHQEFSTKQKLLQNVLEQE-----QEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVT 876
+ L + T + L + E++ ++Q + ++ + K + + S
Sbjct: 2014 EATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGK 2073
Query: 877 SLLDGLNQAFEEVS--SQSGGAKRQSIHLEQKLYDGVSATSTWLD---DVEERLFVATAL 931
L+ Q +E+ G A+ ++I + + + T D + L +A+
Sbjct: 2074 MPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTY 2133
Query: 932 LPEETETCLFNQEILA--KDIKEMSEEMDKNKNL---FSQAFPENGDNRDVIEDTLGCLL 986
L + + L ++ L +D++ M E+ K + E + + L
Sbjct: 2134 LSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ 2193
Query: 987 GRLSLLDSVVNQRCHQMKERLQQILNFQN--DLKVLFTSLADNKYIILQKLANVFEQPVA 1044
SLL + +Q + ++ + + ++K L SL +Q L + +
Sbjct: 2194 DLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDS 2253
Query: 1045 EQIEAIQQAEDGLKEFDAGIIELKRRG-DKLQVEQPSMQELSKLQDMYDELMMIIGSRRS 1103
Q+ + L F + + D++ VE+ +L KLQ++ + L +
Sbjct: 2254 YQV-CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEE----KLQKLQELENRLSL------- 2301
Query: 1104 GLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES 1163
Q+ TLK A + GQ+ + D K + +++++ L K+ + +
Sbjct: 2302 ---QDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLN 2358
Query: 1164 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ 1223
++ ++ K F + + QA++ ++ + + +E + E W +
Sbjct: 2359 SILKSKRSTEKKGKFTLPGREK-------QATSDVQESTQESAAVEKLEEDWEINKDSAV 2411
Query: 1224 ELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLIS 1283
E++ ++ S+ + ++ ED + +NE Q + ++ +L +
Sbjct: 2412 EMAMSKQL---SLNAQESMKNTED------------ERKVNELQNQPLEL----DTMLRN 2452
Query: 1284 ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLE 1343
++E QL K L + E + K T A ++H + + L+
Sbjct: 2453 EQLEEIEKLYTQL-----EAKKAAIKPLEQTECLNKTET-----GALVLHNIGYSAQHLD 2502
Query: 1344 FWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRS 1403
Q +T+ + E L F E+ V+ SS+K+ L T + L++ +D+ T
Sbjct: 2503 NLLQALITLKKNKESQYCVLRDFQEYLAAVE--SSMKA--LLTDKESLKVGPLDSVTYLD 2558
Query: 1404 ELSRIDS---QWTDLLTNIPAVQEKL--HQLQMDKLPSRHAISEVMSWISLMENVIQKDE 1458
++ + + + D L N+ E L H MDK I ++ +E IQK
Sbjct: 2559 KIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY 2618
Query: 1459 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAE 1518
+ + Y + K + +I + +Q + L++ S + +
Sbjct: 2619 S--QQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ------LRLKSPEERAGNQSMIALTT 2670
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK-RLKQQHRIGD 1577
L A + +L+G +++ + G E E+ + LK +ET E L+ +++I
Sbjct: 2671 DLQATKHGFSVLKGQAELQMKRIWGEKEK-KNLEDGINNLKKQWETLEPLHLEAENQI-K 2728
Query: 1578 QASVQNALKD-----------------------------CQDLEDLIKAKEKEVEKIEQN 1608
+ ++N +K+ C+ D I A+++ VE + +
Sbjct: 2729 KCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEE 2788
Query: 1609 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 1668
+ + S + +TL +L + L Q L+ L++ S+ K
Sbjct: 2789 VKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQL 2848
Query: 1669 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 1728
+ E+ +L R+ T + EA L++ LE ++ LQ+ S + L+E
Sbjct: 2849 MVQESE-TLIIPRVETAATEA------ELKHHHVTLEASQKELQEIDSGISTHLQE---- 2897
Query: 1729 VTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYS--------KQC----- 1775
LTN +E+N+ LE+ QL++ K QR+ + K C
Sbjct: 2898 ----LTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHE 2950
Query: 1776 -ASTVQQQED---RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 1831
S +Q++ D R LL NK + ++ I + D L + + L ++
Sbjct: 2951 KTSALQEEADSIQRNELLLNQEVNKGVKEE-----IYNLKDRLTAIKCCILQVLKLKKVF 3005
Query: 1832 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 1891
+ + D S +Q+ + L + KQ + + Y+ + A++
Sbjct: 3006 DYIGLNWDFSQLDQLQTQVFEKEKEL----EEKIKQLDTFEEEHGKYQALLSKMRAIDLQ 3061
Query: 1892 IVEAEEI-LQGQDPSHSS---DLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPL 1946
I + E+ L+ D S S + + +R+E+ K + + +LNE +
Sbjct: 3062 IKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI------IKKLNENKTFDDSF 3115
Query: 1947 NDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQ-------HQTFLEKCETWMEFLVQT 1999
+KEI +++ L + + + + LQ+ +L+ + +K ET + L Q
Sbjct: 3116 KEKEILQIK-------LNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQI 3168
Query: 2000 EQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSII-IDGQRLLEQGQVDDRDE 2056
+ +L + N + H+ ++ E FQ ++++ + ++ I+ QR + D +
Sbjct: 3169 KSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVET 3228
Query: 2057 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 2116
KL + + R +++ RY+E + + + + + +
Sbjct: 3229 ---KLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVD 3285
Query: 2117 VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQE 2176
V P + E+ +++ L ++I + ++ S + A+ LQ L E+
Sbjct: 3286 VGNPEESL-----EMPLRKQEELESTVAHIQDLTEKLGMISSPE--AKLQLQYTLQELVS 3338
Query: 2177 K---WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHA 2233
K K A E + ++ K + K E+ I +L K+ T + SLP + E
Sbjct: 3339 KNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALE 3398
Query: 2234 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
+ K L + + S ++L +L + L + +D L + V L +W L
Sbjct: 3399 RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAK 3458
Query: 2294 LRRQQIGERLNEWAVFSEKNKE---LCEWLTQMESKVSQNGDILIEEMIEKLKK---DYQ 2347
E EW SE+ + + + L + ++S+ + E + +L Y
Sbjct: 3459 EWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYG 3518
Query: 2348 EEIAIAQENKIQLQQMGERLAKASHESKASEIE---YKLGKVNDRWQHLLDLIAARVKKL 2404
E + Q L Q + S A E ++ + +R LL + + +
Sbjct: 3519 ENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELV 3578
Query: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD----SCNSEEIQR-----KLNEQQE 2455
+ + K + +L+ + + D S EE+Q KL +
Sbjct: 3579 QTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENI 3638
Query: 2456 LQRDIEKHS-------TGVASVLNLCEVLLHDCDACATDAECDS-----IQQATRNLDRR 2503
+++ K+S + S + C L D D ++ S +++ ++
Sbjct: 3639 MEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNG 3698
Query: 2504 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 2563
N+ M ++ IE+ + +K D+ + L + E
Sbjct: 3699 LHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----------------SEVQ 3742
Query: 2564 KKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI 2623
E Q E + L + +QY+++++ R + S + + +L K +
Sbjct: 3743 DIVEQDPGQAQEWMDNLMIPFQQYQQVSQ--RAECRTSQLNKATVKMEEYSDLLKSTEAW 3800
Query: 2624 LRRLKHFIGQREEFETARD-----SILVWLTEMDLQLTNIEH-----FSECDVQAKIKQL 2673
+ H + ++++ R S + E Q N+ H + + + +L
Sbjct: 3801 IENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDEL 3860
Query: 2674 KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV 2723
QE+S ++Q I + I++ D IE E+ + + ++
Sbjct: 3861 TQSIQELSNQVTALQQKIMESLPQIQRMAD-DVVAIESEVKSMEKRVSKI 3909
Score = 67.0 bits (162), Expect = 3e-10
Identities = 316/1695 (18%), Positives = 635/1695 (37%), Gaps = 300/1695 (17%)
Query: 1589 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 1635
+ L+ L+K E + + N L + +++ E+ S V+S R+L + W
Sbjct: 311 EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
Query: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 1695
LDH + KI L L A+ + LM+ S S+ + ++ +Q ++
Sbjct: 371 DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
Query: 1696 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 1751
++L D E L +T + E H P+ N L+E+ R NN+LE+ +
Sbjct: 429 LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
Query: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 1807
E +L L K SK ++ + ELL +K I + E + T
Sbjct: 482 LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
Query: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
Q C ++ K L A I + + +C + +
Sbjct: 540 QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
+++LQ + + T+ ++L L A E T +E ++E+ + L
Sbjct: 578 KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
Query: 1928 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 1981
++ + LNE G L ++ K ++ LN+ W + S+T + Q
Sbjct: 621 WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
Query: 1982 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 2037
Q + + + V+ ++VE+ NY ++ HE E + ++
Sbjct: 679 DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
Query: 2038 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 2097
D ++L+ Q ++ W+ + + ++D Q M E
Sbjct: 738 ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
Query: 2098 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 2157
L+ + + S +FDE+ + + L+ I + E+ + +L
Sbjct: 769 SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
Query: 2158 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 2217
+ LQA++ E +EK + ++L K L + D + K + +S ++L ++
Sbjct: 810 T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
Query: 2218 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 2277
+ Q L ++ K E + S T L + + L ++ D L E+
Sbjct: 862 MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
Query: 2278 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 2337
+ +WE L H+LSL QQ+ + EK K L + + ++E ++++ ++
Sbjct: 919 SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
Query: 2338 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 2396
+ L K++ E ++E + QL E L + E + + + ++ ++ ++ ++
Sbjct: 971 RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
Query: 2397 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 2456
+ +K E + +Q S + E+ P +SE K + Q
Sbjct: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
Query: 2457 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 2514
++ +E +ASVL L E + + D A SI D +R+I +E
Sbjct: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
Query: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 2574
L+ + + D+S ED +SS A + VI K+FE ++
Sbjct: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
Query: 2575 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 2634
+ I K + R+ + L+ + N R ++L+ + +L
Sbjct: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
Query: 2635 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 2694
+ S+L+ +++ L I+ F D + L+ Q I+ ++ G
Sbjct: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
Query: 2695 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 2754
++++ P D ++ + + + + + RV+R L
Sbjct: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
Query: 2755 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER-SGRDTPASVDSIPLEWDHDY 2813
AL D R+A LS +P ++LS S Q + + ++ + + + H
Sbjct: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD 1378
Query: 2814 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS-ALESQIRQLGKALDDSRFQ 2872
+ L+ + A +D ++ D + ++ LS H ++ + + K L+ F+
Sbjct: 1379 KCLKMLDMSFKDAERGDDTSCENLLDAF---SIKLSETHGYGVQEEFTEENKLLEACIFK 1435
Query: 2873 ----------IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 2922
+Q + I K PT P + K ++L +D + + L+E
Sbjct: 1436 NNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRL----DKVLDEYEEEKRHLQEMA 1491
Query: 2923 ESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELRMKQNLQKWQQFNSDLNSIW 2977
SLP F + + Q + WE L + L + R+ + L+++Q F S L +
Sbjct: 1492 NSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTT-- 1549
Query: 2978 AWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC--- 3029
L EE + LQ + L I IE+ ++ E + VD + ++
Sbjct: 1550 --LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607
Query: 3030 -----SPEFTQAD----------SKESRDLQDRLSQMNGRWDRVCSL---LEEWRGLLQD 3071
P F + ++++ D + L + WD++ +L ++EW +
Sbjct: 1608 MKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW----TE 1663
Query: 3072 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQL 3131
+Q H+++ E+ +R K E+ + + + +++ +I+ L S++
Sbjct: 1664 KALQKMELHQLTE------EDRERLKEEL-----QVHEQKTSEFSRRVAEIQFLLQSSEI 1712
Query: 3132 RVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKLLLKEVSRHIKELEKLLDVS 3187
+ LQ M +L E CL + H + L+ L + I E LL
Sbjct: 1713 PL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKAL 1771
Query: 3188 SSQQDLSSWSSADEL 3202
S L ++ +E+
Sbjct: 1772 SPSDSLEIFTKLEEI 1786
Score = 52.0 bits (123), Expect = 1e-05
Identities = 259/1388 (18%), Positives = 524/1388 (37%), Gaps = 207/1388 (14%)
Query: 18 GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW---IEKAKVLA 74
G L + L +Q + ++ R +L LEE + +I K+ +++++ L
Sbjct: 2801 GSDLNNTLEDLRNQYQMLVLKSTQRSQQLE---FKLEERSNFFAIIRKFQLMVQESETLI 2857
Query: 75 HGTIAWNSA-SQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY----CTEKM--S 127
+ + ++L+ ++ + +E +EIDS ++ LQ LT++Y E++
Sbjct: 2858 IPRVETAATEAELKHHHVTLEASQKELQEIDS---GISTHLQELTNIYEELNVFERLFLE 2914
Query: 128 QQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRL 187
Q+ L T +++ I+ ++ K ++F + LQ + Q L
Sbjct: 2915 DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRN-------EL 2967
Query: 188 SLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQE------ 241
L ++++ + + E+ +LK ++ A++ C + + V + L +L +
Sbjct: 2968 LLNQEVN--KGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVF 3025
Query: 242 EASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQ 301
E + I+Q + + +Y+ +M+ + I+ + P ++ + L AQ
Sbjct: 3026 EKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQ 3085
Query: 302 ISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATML---LTVTEVEGLAEGTEDLDGE 358
I + +K K ++I ++ K K +L L E + L + +++ E
Sbjct: 3086 IL--SQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLE 3143
Query: 359 LLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQ 418
L P + H L S++ P +N
Sbjct: 3144 LSPKELDEKNCQDKLETSLHVL----------NQIKSQLQQP-------------LLINL 3180
Query: 419 DIAYYQ------ALSAERLQTDAAKIHPSTSASQEFYEPGLEPS-ATAKLGDLQRSWETL 471
+I + Q E++ + I T+ ++ E E S KL + + L
Sbjct: 3181 EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL 3240
Query: 472 KNVISEKQRTLYEALERQQKYQDSL----QSISTKMEAIELKLS-ESPEPGRSPESQMAE 526
I + L +A E +Y++++ +SI T +EAI + + P S E + +
Sbjct: 3241 NTSIDLRTNVLNDAYENLTRYKEAVTRAVESI-TSLEAIIIPYRVDVGNPEESLEMPLRK 3299
Query: 527 HQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKAS 586
+ L + +QD L E+L S P +L LQ TL L + S MK +
Sbjct: 3300 QEELESTVAHIQD--------LTEKLGMIS---SPEAKLQLQYTLQELVSKNSA--MKEA 3346
Query: 587 GKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQ 646
K Q E E+ L+ Y+C +++ + + + ++T L M +
Sbjct: 3347 FKAQ-----------ETEAERYLENYKCYR-KMEEDIYTNLSKMETVLG-----QSMSSL 3389
Query: 647 LMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGS------- 699
+ + L +EQ +S L TK+E +L LR L+
Sbjct: 3390 PLSYREALERLEQSKALVSNL------------ISTKEELMKLRQILRLLRLRCTENDGI 3437
Query: 700 -LLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQ 758
LL++ AL +K L++ A+E E W + + W
Sbjct: 3438 CLLKIVSALWEKWLSLLEAAKEWEM---------------WCEELKQEW----------- 3471
Query: 759 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ 818
K + +E+ + +L ++ EI AA T + E D L Q G EK
Sbjct: 3472 KFVSEEIEREAIILDNLQEELPEISKTKEAATTE-ELSELLDCLCQ-YGENVEKQQLLLT 3529
Query: 819 MRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT--QDKSAVT 876
+ ++ Q ++ V ++ + R N+LL V K V T Q++ + T
Sbjct: 3530 LLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFT 3589
Query: 877 SLLDGLNQAFEEVSSQSGGAKRQSIHLE-----QKLYDGVSATSTWLDDVEERLFVATA- 930
+ L F++ ++ Q H E ++L + +++ E+L + +
Sbjct: 3590 KEIIALKNFFQQTTTSFQNMAFQD-HPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSE 3648
Query: 931 ---LLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLG 987
++P E E+ + +DI E K N ++ P R + E
Sbjct: 3649 MYTIVPAEIESQVEECRKALEDIDE------KISNEVLKSSPSYAMRRKIEE-------- 3694
Query: 988 RLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI 1047
+N H +++ LQQ + + + D + KL N + V + +
Sbjct: 3695 --------INNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKL-NELDSEVQDIV 3745
Query: 1048 EAIQ-QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLN 1106
E QA++ + + ++ + + + + + + Y +L+ + +
Sbjct: 3746 EQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTS 3805
Query: 1107 QNLTLKSQYE--RALQDLADLLETGQEKMAGDQKIIVSSKEEIQQL--LDKHKEYFQGLE 1162
L + Y+ R L A ++ E ++ S +++ L + + E Q ++
Sbjct: 3806 HLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQ 3865
Query: 1163 SHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 1222
L +KI+ Q + + +++A S V K KR +++ IL + D
Sbjct: 3866 ELSNQVTALQQKIMESLPQIQ-RMADDVVAIESEV-KSMEKRVSKIKTILLSKEIFDFSP 3923
Query: 1223 QELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
+E + EV+ +I + + I I YQ ++ L + K V +LL
Sbjct: 3924 EEHLKHGEVILENIRPM-------KKTIAEIVSYQ-VELRLPQTGMKPLPVFQRTNQLLQ 3975
Query: 1283 SISC-SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS------ESADLIHWL 1335
I ++ + N+L + + TN+ +E+ L+ IL +++ S + AD + L
Sbjct: 3976 DIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQL 4035
Query: 1336 QSAKDRLE 1343
Q +R+E
Sbjct: 4036 QGEIERME 4043
Score = 41.2 bits (95), Expect = 0.017
Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)
Query: 2945 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 3004
W LQ + L K L+ +N ++++NS L+ + ++ EE+ L L + D+ ++
Sbjct: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
Query: 3005 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 3060
+L+E +DH+ A + +N P T+A +E +L D + + +
Sbjct: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
Query: 3061 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 3120
L++E L + + + E +LL EN D +VP
Sbjct: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
Query: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 3168
++L E + R+ ++ + LL+ CL E K K+ + G+R ++L
Sbjct: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
Query: 3169 LLKEVSRHIKELEKLLDVSSSQQ 3191
LL++ + I+E E L + +S Q
Sbjct: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
[Homo sapiens]
Length = 6885
Score = 1954 bits (5061), Expect = 0.0
Identities = 1200/3329 (36%), Positives = 1858/3329 (55%), Gaps = 124/3329 (3%)
Query: 27 KLTELHQQTIRQAENRLSKLNQAASHLEEY--NEMLELILKWIEKAKVLAHGTIAWNSAS 84
K +E++ + E+++ + +A ++E NE+L+ + + K+ N
Sbjct: 3645 KYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEK 3704
Query: 85 QLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY--CTEKMSQQVAELG-------R 135
L+++ + E K++ EL+ KL L S E+ Q E +
Sbjct: 3705 MLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQ 3764
Query: 136 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 195
+ +++ Q + R L A M+++ LK +A +E L +P LSH
Sbjct: 3765 QYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSH 3822
Query: 196 RQHLLSEMESLKPKVQAVQLCQSALRIPED---VVASLPLCHAALRLQEEASRLQHTAIQ 252
H + +L+ Q L S ED + + L + L + + LQ ++
Sbjct: 3823 --HASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIME 3880
Query: 253 QCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKI 312
+Q E E+K +++ + + K + + +E + E + + I
Sbjct: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE---HLKHGEVILENI 3937
Query: 313 KGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMM 372
+ ++ IA + S L + L L + + L+ V+
Sbjct: 3938 RPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQ 3997
Query: 373 TAGRCHTL--LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS--A 428
T + L + + + +S A + P + Q ++ Q
Sbjct: 3998 TNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLL 4057
Query: 429 ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALER 488
L+ +H QE E P+ T++ G + + SE++ ++
Sbjct: 4058 VDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVA------ERDASERKLNRRGSMSY 4111
Query: 489 QQKYQDSLQSISTKMEAIELKLSESPEPGRS---PESQMAEHQALMDEILMLQD---EIN 542
++ ++ S K + + K SP+ S + M E +A ++Q+ +I+
Sbjct: 4112 LAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKIS 4171
Query: 543 ELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL-LEEKLNDQLE 601
+S+A+ L +S + + +L+ T E +T ++A + L ++E
Sbjct: 4172 TSDNSMAQILTPDSLNTEQGPECSLRPNQT---EEGTTPPIEADTLDSSDAQGGLEPRVE 4228
Query: 602 EQRQE--QALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQ 659
+ R E + L + + EL+ WL ++ +E QL+ CQ ML EIE
Sbjct: 4229 KTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEH 4288
Query: 660 KVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ 719
KV L E ++ L T+ EAE L+ KL+ +K +L ++Q L +K Q
Sbjct: 4289 KVAFLLETC---KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTI 4345
Query: 720 EKEESDVDLTATQSPGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASR 778
K+ S+ + P L T Q RQ QQQ+ LE + EQK ++ +
Sbjct: 4346 LKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFN 4405
Query: 779 GEEILIQHSAAE--TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKL 836
+++ Q+ + T+ ++ S E + S + Q KW+ LH E S+K KL
Sbjct: 4406 AKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKL 4465
Query: 837 LQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGG 895
L + Q S +L V +Y PT ++ T+ L+ L Q + +Q
Sbjct: 4466 PLPQLVEPQ----VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENM 4521
Query: 896 AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSE 955
+ I+L++KL++ S L VEE L + L E+ + E LA ++K++
Sbjct: 4522 TEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPR-LYREDGSGQQVHYETLALELKKLYL 4580
Query: 956 EMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQN 1015
+ K +A G+N +++ + L L + R +K L ++QN
Sbjct: 4581 ALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQN 4640
Query: 1016 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 1075
++K L+ L +K + Q L + Q VAEQ++ L+ ++ + +L+ G++L
Sbjct: 4641 EIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLH 4700
Query: 1076 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 1135
+ +QE+ KL+D+ D + ++ +R + L+ +SQ + LQ + +L++ G+EK+A
Sbjct: 4701 LPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAH 4760
Query: 1136 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 1195
SK +Q ++ HK +FQ L + M+L + KI+ +Q F E + +
Sbjct: 4761 GHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVK 4820
Query: 1196 AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL 1255
+ +++ + G++L+ +L+ W DE+ L + LE++ S++PSV LVEE E+RL++RI+
Sbjct: 4821 ILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISF 4880
Query: 1256 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 1315
YQ +K ++ +LYQ L++GK+L+ S+SC +LE Q+ +L E WLS K+ ELHRL+
Sbjct: 4881 YQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
Query: 1316 TILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDA 1375
+LKH Y +S L WL+S++ L +W +QS+ V Q+L+ +R ++N F EFSKEVD
Sbjct: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
Query: 1376 QSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 1435
+SSLK++V+S GNQLL LK+ DTATLR+ L++ + +WT L+T +P +QEKLHQLQM+KLP
Sbjct: 5001 KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
Query: 1436 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 1495
SR AI+E++SW++ +E+ DED++ + + LQK+K F+++++ KQ VDFVN
Sbjct: 5061 SRKAITEMISWMNNVEHQTS-DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
Query: 1496 QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 1555
QS+LQ+S+ DVESKR ++T+FAE LG MN+ W + G++ KIQ LE LLES +E EN +
Sbjct: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
Query: 1556 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 1615
Q L W E QE+RLK + SVQ L DCQD+E+ + K K +++++Q+ L L ++
Sbjct: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL-ES 5238
Query: 1616 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARY 1675
+ S + EL Q +++ V QLK ++SVL +W + +D++N + Y
Sbjct: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
Query: 1676 SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTN 1735
+ + + SLE ++ QV+NLQ+LQD+ E E S +K + +L C P V E +
Sbjct: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEE 5357
Query: 1736 TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN 1795
+ + RW + + IA+QLQ +++LLQLW+ Y + + A+ ++QQE + +L + +
Sbjct: 5358 KCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMS 5417
Query: 1796 KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQ 1855
+ + + +QD +L + K++ + ++L Q ++S + SL Q
Sbjct: 5418 GNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-Q 5476
Query: 1856 HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQE 1915
LE+ L + + + ++ F LE+L+ I+ EE L D H + +E
Sbjct: 5477 RAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---DRLHQQE----KE 5529
Query: 1916 RMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL 1975
+ +L ++ +PD++ LNE+ +LPL+D +K +QN+NR W ++ ER S+L
Sbjct: 5530 NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSEL 5589
Query: 1976 QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQIL 2035
Q L ++ FL CE W++ L + E+ L V+++ + LLEQQ+ +++ +AE+ Q I
Sbjct: 5590 QGIGL-NEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIA 5648
Query: 2036 HSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 2095
S + +LL+ ++++R EF + + L+++WQ ++ +QR+G +D +RQWQ +
Sbjct: 5649 DSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTS 5708
Query: 2096 AEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL 2155
E L ++L + S+L + G L Q R+L E++ KE F R++ + LT+EAG++L
Sbjct: 5709 VENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKL 5768
Query: 2156 LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT 2215
LL+ D + ++ ++++Q+ WK +L E K+ ++ W++CEK I + +L+
Sbjct: 5769 LLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQV 5828
Query: 2216 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 2275
K + LP+ HE+LH E+ KELE ++ SWT +L +L +K L+ ++ +D+ +L
Sbjct: 5829 LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK 5888
Query: 2276 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI 2335
E++E L RQWE+LC ++++R+Q+I +RLN W VF+EKNKELC WL QME+KV Q DI I
Sbjct: 5889 EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISI 5948
Query: 2336 EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLD 2395
EEMIEKL+KD EEI + ENK+QL+QMG++L KAS++S+A+EI+ KL K+NDRWQHL D
Sbjct: 5949 EEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFD 6008
Query: 2396 LIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQE 2455
+I +RVKKLKET +QQLDKNMS+LRTWLA IESEL+KP+VYD C+ +EIQ++L EQQ+
Sbjct: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQD 6068
Query: 2456 LQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR 2515
LQRDIE+HS GV SV N+C+VLLHD DACA + ECDSIQQ TR+LDRRWRNICAMSMERR
Sbjct: 6069 LQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR 6128
Query: 2516 LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE 2575
+KIEETWRLWQKFLDDYSRFEDWLKS+ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE
Sbjct: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHE 6188
Query: 2576 CLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE 2635
LTQLELINKQYRRLARENRTD+A LKQMVHEGNQRWDNLQ+RVT++LRRL+HF QRE
Sbjct: 6189 RLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQRE 6248
Query: 2636 EFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGE 2695
EFE R+SILVWLTEMDLQLTN+EHFSE D K++QL FQQEI+LN NKI+Q+I GE
Sbjct: 6249 EFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGE 6308
Query: 2696 QLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELE 2754
QLI+KSEPLDA +IE+EL+EL RYCQEVFGRV R+H++L P +DE + S+ E ++E
Sbjct: 6309 QLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDME 6368
Query: 2755 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD 2814
D + W R S +PSS SL ERSG +TP SVDSIPLEWDH D
Sbjct: 6369 DPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGD 6424
Query: 2815 LSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQ 2874
+ S EE ++ + +S HS + + Q++
Sbjct: 6425 VGGS----------SSHEEDEEGPYYSALSGKSISDGHS---WHVPDSPSCPEHHYKQME 6471
Query: 2875 QTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 2931
N+ P P T YK G + L + + L ++E+ L G
Sbjct: 6472 GDRNV----PPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE- 6526
Query: 2932 HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 2991
Q +G DRWE++QAQ L +L++KQNL QQ NSD+++I WL TE ELE L+
Sbjct: 6527 -----QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK 6578
Query: 2992 RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 3051
+ +DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q+
Sbjct: 6579 MAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQL 6638
Query: 3052 NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 3111
+ W+ ++ WRG L+ +LMQCQ FH++S LLL L + R+ + D D
Sbjct: 6639 SLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRA 6698
Query: 3112 LQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLK 3171
L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI +LK L +
Sbjct: 6699 LLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLRE 6758
Query: 3172 EVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQ 3231
+VS + L+ + +Q S S DE+D SG P + P R K R
Sbjct: 6759 QVS------QDLMALQGTQNPASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA------ 6804
Query: 3232 PGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPM 3291
R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+ LACL+P
Sbjct: 6805 ---------VRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPS 6855
Query: 3292 SEEDYSCALSNNFARSFHPMLRYTNGPPP 3320
SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 6856 SEEDYSCTQANNFARSFYPMLRYTNGPPP 6884
Score = 218 bits (554), Expect = 1e-55
Identities = 505/2767 (18%), Positives = 1073/2767 (38%), Gaps = 296/2767 (10%)
Query: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
ELD+ VQ +EQ+ + + + +QQ ++AE R S+LN+A +EEY+++L+
Sbjct: 3736 ELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLK 3795
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
WIE L ++S L Q LE+S++ + L ++ L+ L+ ++
Sbjct: 3796 STEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIF 3855
Query: 122 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTS 181
T++++Q + EL + L+Q I L +Q A D+ E+E+K ++ + + + L S
Sbjct: 3856 ETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLS 3915
Query: 182 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQE 241
E+ S +E L H + +L + +K + + Q LR+P+ + LP+ +L +
Sbjct: 3916 KEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQ 3975
Query: 242 EASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE--GAHREIED-KPVATSNIQEL 298
+ L++ +Q +++ + Q ++++E+++L+Q++ A +E P + +L
Sbjct: 3976 DIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQL 4035
Query: 299 QAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE----- 353
Q +I R E +QI SLN + + L + K AT+L ++ EG E
Sbjct: 4036 QGEIERME----------KQILSLNQRKEDLLVDLK-ATVLNLHQHLKQEQEGVERDRLP 4084
Query: 354 ---DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVA 410
+G + ++ + + + EES + N + + P+ +S S +
Sbjct: 4085 AVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLW 4144
Query: 411 NTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEP-----------GLEPSATA 459
D + +D A + S +Q KI S ++ + P L P+ T
Sbjct: 4145 KHDKDMEEDRA--SSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQTE 4202
Query: 460 KLGDLQRSWETLKNVISEKQRTLYEALER-QQKYQDSLQSISTKMEAIELKLSESPEPGR 518
+ +TL + S+ Q L +E+ + + + L + T++ +EL L ++
Sbjct: 4203 EGTTPPIEADTLDS--SDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQA-NVAV 4259
Query: 519 SPESQMAEHQALMDEILM-LQDEINELQSSLAEELVSESC-EADPAEQLALQSTLTVLAE 576
PE+ A+ Q ++++ L+ Q + E++ +A + E+C + + A Q L+
Sbjct: 4260 EPETLNADMQQVLEQQLVGCQAMLTEIEHKVA--FLLETCKDQGLGDNGATQHEAEALSL 4317
Query: 577 RMSTIRMKASGKRQLLEEKLND--------QLEEQRQEQALQRYRCEADELDSWLLSTKA 628
++ T++ + +L+EK ++ + E ++ALQ EL+S + T+
Sbjct: 4318 KLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQ--PVNLSELES--IVTER 4373
Query: 629 TLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVAL-SELSVHNENLLLEGKAHTKDEAE 687
+ ++ +E + M+ ++ + IE + + H+ + E A +
Sbjct: 4374 PQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSA-----SN 4428
Query: 688 QLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK--------EESDVDLTATQSPGVQEW 739
Q + + S+L Q DK + K E V P V +
Sbjct: 4429 QASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMY 4488
Query: 740 ------LAQARTTWTQ-----QRQSSLQQQK--------ELEQELAEQKSLLRSVASRGE 780
+ +T TQ Q S+LQ Q+ L+++L E L S E
Sbjct: 4489 NFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVE 4548
Query: 781 EILIQHSAAETSGDAGE-KPDVLSQE-----LGMEGEKSSAEDQMRMKWESLHQEFSTKQ 834
E+L G + + L+ E L + +K M E+ +
Sbjct: 4549 EMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFD 4608
Query: 835 KLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL---DGLNQAFEEVSS 891
LQ LE Q + R L +G+ Y + K L+ L Q+ E+S
Sbjct: 4609 N-LQVCLEHTQAAAV-CRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEISG 4665
Query: 892 QSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIK 951
QS + Q + + L D ERL + ALL E +
Sbjct: 4666 QSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE---------------VY 4710
Query: 952 EMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL----DSVVNQRCHQMKERL 1007
++ + +D + + E L G + L+ + + + Q K ++
Sbjct: 4711 KLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKV 4770
Query: 1008 QQILNFQNDLKVLFTSLADNKYI-------ILQKLANVFEQPVAEQIEAIQQAEDGLKEF 1060
+N KV F L + + IL L E AEQ+ ++ E+ ++
Sbjct: 4771 ALQAQIENH-KVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQC 4829
Query: 1061 DAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 1120
+ L ++ ++ S+++ ++ + ++ L + ++ Q +R +
Sbjct: 4830 GMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
Query: 1121 DL-ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGL----ESHMILTETLFRKI 1175
A L +T E G Q + S E++ + K +E + L + + + L + +
Sbjct: 4890 GKHARLYQTLNE---GKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHL 4946
Query: 1176 ISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESS 1235
+S+ +++ T+ + + ++ L W E +S+ L+ + S+
Sbjct: 4947 LSY--NRDSDQLTKWLESS--------------QHTLNYWK---EQSLNVSQDLDTIRSN 4987
Query: 1236 IPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL--LISISCSDLESQL 1293
I + + D KSSL V+ G +L L + L + L
Sbjct: 4988 INNFFEFSKEVDE-----------KSSLKT------AVISIGNQLLHLKETDTATLRASL 5030
Query: 1294 NQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVP 1353
Q + W ++ +L + + ++I W+ + + + + SV P
Sbjct: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS--DEDSVHSP 5088
Query: 1354 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSE-------LS 1406
V+ L EF E+D + + V LL+L D + R E L
Sbjct: 5089 SSASQVKHLLQKHKEFRMEMDYKQWIVDFV---NQSLLQLSTCDVESKRYERTEFAEHLG 5145
Query: 1407 RIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLME---NVIQKDEDNIKN 1463
++ QW + + + L QL S + I + +W+ E +QK E I
Sbjct: 5146 EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVI-- 5203
Query: 1464 SIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAM 1523
++ + L + + + K +D + QS L + S V + +
Sbjct: 5204 -----SVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPL-------LEDTASRI 5251
Query: 1524 NKSWQILQGLVTEKIQL---LEGLLESWSEY-----ENNVQCLKTWFETQEKRLKQQHRI 1575
++ +Q ++T+ QL ++ +L+ W Y E N+ ++ W+ + + +
Sbjct: 5252 DELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK----PVV 5307
Query: 1576 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTW 1635
+++ +++ Q L+D ++ E EK+ Q + ++ V+ I+ + + W
Sbjct: 5308 LSLETLRCQVENLQSLQDEAESSEGSWEKL-QEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
Query: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL--MEARYSLSRFRLLTGS--LEAVQ 1691
++ + +S+L W ++ A + + L EA++ ++G+ E +
Sbjct: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
Query: 1692 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751
+ +++ LQ D++K + + + S+ ++L P E+ T+ L L +
Sbjct: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRL-----PQPAESSTHMLLP------GPLHSL 5475
Query: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCN 1811
K LL ++ Q + E ++ N D +
Sbjct: 5476 QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFL 5535
Query: 1812 DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQS-DQLSLSQHLCALEQALCKQQTS 1870
+ + L + L+E+ LK + A +Q+ ++ + ALE+ Q
Sbjct: 5536 NHVLALTAQSPDIEHLNEV--SLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIG 5593
Query: 1871 LQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELK--------G 1922
L K L E WI E+I + ++ L + E+ + K
Sbjct: 5594 LN---------EKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
Query: 1923 QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH 1982
Q + S + L L+ + + I L W +R + + Q
Sbjct: 5645 QTIADSYVTQSLQLLDTT--EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQW 5702
Query: 1983 QTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA--HELFQAEM-FSRQQILHSII 2039
Q F E FL T L+ + G + L Q R+ HEL E+ F R++ ++
Sbjct: 5703 QDFTTSVENLFRFLTDTSHLLSA-VKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALT 5761
Query: 2040 ID-GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
++ G++LL + ++ +++ L + W+ + + + S + W + + ++
Sbjct: 5762 LEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKE 5821
Query: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158
L+ L + L + L + L E++ + Q + T++A +
Sbjct: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELE-QSLASWTQNLKELQTMKADLTRHVL 5880
Query: 2159 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKK 2218
+ L+ ++ + +W+ +R+ +K+++ L W + + L +
Sbjct: 5881 VED--VMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMEN 5938
Query: 2219 KLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERV 2278
K+ Q+ EE+ E+++ K+ + ++++ QL + D L + + +++++
Sbjct: 5939 KVLQTADISIEEM-IEKLQ-KDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKL 5996
Query: 2279 ELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIE 2336
+ +W+ L + R +++ E + L WL ++ES++S+ D+ +
Sbjct: 5997 NKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDD 6056
Query: 2337 EMIEK-------LKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDR 2389
+ I+K L++D ++ A + + ++E++ I+ ++ R
Sbjct: 6057 QEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRR 6116
Query: 2390 WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKP----IVYDSCNSEE 2445
W+++ + R K++ET Q+ + S WL E A P ++Y S E
Sbjct: 6117 WRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE- 6175
Query: 2446 IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWR 2505
L + QR I + T + + L + TD ++Q ++RW
Sbjct: 6176 ----LKRFEAFQRQIHERLTQLELINKQYRRLARE---NRTDT-ASRLKQMVHEGNQRWD 6227
Query: 2506 NICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIYTVAK 2560
N+ + ++ R + F + FE +S +E + + A
Sbjct: 6228 NL-------QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD 6280
Query: 2561 EELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV 2620
+++++ FQ+++ +++ + +L +++ A ++ + E ++ + RV
Sbjct: 6281 DKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV 6340
Query: 2621 TSILRRL 2627
+ RRL
Sbjct: 6341 SRFHRRL 6347
Score = 120 bits (300), Expect = 3e-26
Identities = 659/3526 (18%), Positives = 1282/3526 (36%), Gaps = 572/3526 (16%)
Query: 6 AVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILK 65
A++K E+N + K+ + +L Q + R + LN A +L Y E + ++
Sbjct: 3211 AIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVE 3270
Query: 66 WIE--KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCT 123
I +A ++ + N L E + Q EE + + ++ +TEKL ++S
Sbjct: 3271 SITSLEAIIIPYRVDVGNPEESL-EMPLRKQ---EELESTVAHIQDLTEKLGMISSPEAK 3326
Query: 124 EKMSQQVAELGRETEELRQMIKIR-------LQNLQDAAKDMKKFEAELKKLQAALEQAQ 176
++ + EL + +++ K + L+N + K + L K++ L Q+
Sbjct: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSM 3386
Query: 177 ATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAA 236
++L P R +L E+L + L+S + S K ++ ++ LR+ + L
Sbjct: 3387 SSL--PLSYREAL-ERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIV 3443
Query: 237 LRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ 296
L E+ ++++AA +++E + L+Q + EIE + + N+Q
Sbjct: 3444 SALWEK----------WLSLLEAA----KEWEMWCEELKQEWKFVSEEIEREAIILDNLQ 3489
Query: 297 ELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD 356
E +IS+ +E A +E L+ C+ K +L + + + +
Sbjct: 3490 EELPEISKTKEAATT----EELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
Query: 357 GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 416
G + P+ M RC+ LL V + N E+ S A
Sbjct: 3546 GAVETVPAFQEITSMKE--RCNKLLQKVQK-------NKELVQTEIQERHSFTKEIIALK 3596
Query: 417 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL--QRSWETLKNV 474
N ++Q + Q A + HP S E E + K G L + E L+
Sbjct: 3597 N----FFQQTTTS-FQNMAFQDHPEKSEQFE------ELQSILKKGKLTFENIMEKLRIK 3645
Query: 475 ISEKQRTLYEALERQ-QKYQDSLQSISTKMEAIELKLSES-------------------- 513
SE + +E Q ++ + +L+ I K+ LK S S
Sbjct: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
Query: 514 -PEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLT 572
+ ++ E + + DE+ + ++NEL S V + E DP + L
Sbjct: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSE-----VQDIVEQDPGQAQEWMDNLM 3760
Query: 573 VLAERMSTIRMKAS------GKRQLLEEKLNDQLE--EQRQEQALQRYRCEADELDSWLL 624
+ ++ + +A K + E+ +D L+ E E AD L
Sbjct: 3761 IPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTL 3820
Query: 625 STKA-TLDTALSPPKEPMD-MEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGK--- 679
S A T+ AL ++ + + + MD +++ + E + S + N+ L+ K
Sbjct: 3821 SHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIME 3880
Query: 680 -----AHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDL------ 728
D+ + +++ ++ + +++ L K++ + + +V L
Sbjct: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPM 3940
Query: 729 --TATQSPGVQEWLAQARTTWT-----QQRQSSLQQQKELEQELAEQKSLLRSVASR--- 778
T + Q L +T Q+ LQ K LE EQ LL+ V +
Sbjct: 3941 KKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNE 4000
Query: 779 -GEEI-----LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ---MRMKWESLHQE 829
EEI ++ + +A+ S + PD + ++GE E Q + + E L +
Sbjct: 4001 WDEEIENLKQILNNYSAQFSLE-HMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD 4059
Query: 830 FSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS-------AVTSLLDGL 882
L L+QEQE V R L V +G V +D S S L +
Sbjct: 4060 LKATVLNLHQHLKQEQEGVERDR----LPAVTSEEGGVAERDASERKLNRRGSMSYLAAV 4115
Query: 883 NQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDD---VEERLFVATALLPEETETC 939
+ EE S +S ++ Q S +S W D E+R ++ + +E
Sbjct: 4116 EEEVEESSVKSDNGDEKAEPSPQ------SWSSLWKHDKDMEEDRASSSSGTIVQEAYGK 4169
Query: 940 LFNQ-----EILAKDI--KEMSEEMDKNKNLFSQAF--PENGDNRDVIEDTLGCLLGRLS 990
+ +IL D E E N + P D D D G L R+
Sbjct: 4170 ISTSDNSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLD-SSDAQGGLEPRVE 4228
Query: 991 LLDSVVNQRCHQMKERLQQILNFQNDLKVLF---TSLADNKYIILQKLANV------FEQ 1041
+ H K ++ ++ + V T AD + ++ Q+L E
Sbjct: 4229 KTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEH 4288
Query: 1042 PVAEQIEAIQQ---AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMII 1098
VA +E + ++G + +A + LK + K +E+ M LQ+ + E
Sbjct: 4289 KVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMM----LQEKHSEDQHPT 4344
Query: 1099 GSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYF 1158
++S + +++ ALQ + + + IV+ + + + D ++
Sbjct: 4345 ILKKSS-------EPEHQEALQPV----------NLSELESIVTERPQFSRQKDFQQQQV 4387
Query: 1159 QGLESHMILTETLFRKIISFAVQK----ETQFHTELMAQASAVLKRAHKRGVELEYILET 1214
L+ + + F K I F +K Q + ++SA + + + IL
Sbjct: 4388 LELKP---MEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSP 4444
Query: 1215 WSHLDEDQQELSRQLEVVESSIPSVGLVEENEDR---LIDRITLYQHLKSSLNEYQPKLY 1271
+ Q L +L + +P LVE ++ +T+Y + E +
Sbjct: 4445 QGQNGDKWQYLHHELS-SKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTT 4503
Query: 1272 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNK-------MSKELHRLETILKHWTRY 1324
Q+ D + S+L++Q N E +++ K +S+ L +E +L+ Y
Sbjct: 4504 QLED------LRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLY 4557
Query: 1325 QSE-SADLIHWLQSAKDRLEFWTQ---------QSVTVPQE----LEMVRDHLNAFLEFS 1370
+ + S +H+ A + + + +++T P E L D+L LE +
Sbjct: 4558 REDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHT 4617
Query: 1371 KEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 1430
+ A + +S L G R + ++E+ R+ HQL
Sbjct: 4618 Q---AAAVCRSKSLKAGLDYNR-------SYQNEIKRL-----------------YHQL- 4649
Query: 1431 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT 1490
+ S SL +++ N I +++ E LQK + +++
Sbjct: 4650 ------------IKSKTSLQQSL---------NEISGQSVAEQLQKADAYTVEL------ 4682
Query: 1491 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLES-WS 1549
++ ES+ + D E+L L + +++ LE +L+S W
Sbjct: 4683 -------------ENAESRVAKLRDEGERLH--------LPYALLQEVYKLEDVLDSMWG 4721
Query: 1550 EYENNVQCLKTWFETQEKR------LKQQHRIGDQASVQNALKDCQD---LEDLIKAKEK 1600
L + F T+ ++ + + +IG + LK + L+ I+ +
Sbjct: 4722 MLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKV 4781
Query: 1601 EVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN-------LDHMVGQLKILLKSVL 1653
+K+ + + LIQ + I+ S L+ WA L+ Q + L+S+L
Sbjct: 4782 FFQKLVAD-MLLIQAYS---AKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
Query: 1654 DQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQK 1713
+W + + L +L L+ + E + ++ Q ++ ++ + L +
Sbjct: 4838 QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ 4897
Query: 1714 FGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSK 1773
+ QL+ P E L+E +W +L ++I +L +ALL+ Y S
Sbjct: 4898 TLNEGKQLVASVSCPELEGQIAKLEE---QWLSLNKKIDHELHRLQALLKHLLSYNRDSD 4954
Query: 1774 QCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 1833
Q ++ + N + + N D + + I + + K + + +G Q
Sbjct: 4955 QLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ 5014
Query: 1834 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 1893
L + A+ +++ Q L L Q L ++ K++ + +W+
Sbjct: 5015 LLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMN 5073
Query: 1894 EAEEILQGQDPSHS-SDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIK 1952
E +D HS S S ++ +++ K ++ +D +N+ +L D E K
Sbjct: 5074 NVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESK 5133
Query: 1953 RMQ---------NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL 2003
R + +NR W + + L+ L K + +L E++L
Sbjct: 5134 RYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERL 5193
Query: 2004 AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRL---------LEQGQVDDR 2054
L++ + Q + Q I + + I + L LE G V
Sbjct: 5194 KT---------LQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLL 5244
Query: 2055 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 2114
++ ++ L + V+ + Q + + S +++W+ Y ++ +++ + Y M
Sbjct: 5245 EDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYC-MEHS 5303
Query: 2115 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEI 2174
V + L+ R + +Q + +GS+ E +L S AE ++ +
Sbjct: 5304 KPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAE-IIEEKCQNT 5362
Query: 2175 QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK------LSQSLPDHH 2228
++W + + +Q +K LL+ W+ ++ +L+ + K +S S +
Sbjct: 5363 HKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLA 5422
Query: 2229 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEEL 2288
E L KEL++ V + Q S + D L + +L + LQR
Sbjct: 5423 EILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQR----- 5477
Query: 2289 CHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE 2348
+ + + + NE+ + K+ L ++ + EE +++L + +E
Sbjct: 5478 ---AAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHE-----EENLDRLHQQEKE 5529
Query: 2349 EIAIAQENKIQLQQMG---ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKL 2404
+ + L E L + S + S++ K L +N +W + A +++
Sbjct: 5530 NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQW---IRATATALERC 5586
Query: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS-EEIQRKLNEQQELQRDIEKH 2463
E L + +K + W+ +E ++ + + D NS E+ + + L+ ++ +
Sbjct: 5587 SE-LQGIGLNEKFLYCCEKWIQLLE-KIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
Query: 2464 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 2523
T S + LL D + + I + ++ D RW+N +R+ ++ R
Sbjct: 5645 QTIADSYVTQSLQLL---DTTEIENRPEFITEFSKLTD-RWQNAVQGVRQRKGDVDGLVR 5700
Query: 2524 LWQ----------KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV 2573
WQ +FL D S +K ER + + + S +I+ + +E+ FQR+
Sbjct: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRS-LIHELKNKEIH----FQRRR 5755
Query: 2574 HECLTQLELINKQY------------RRLA--RENRTDSACSLKQMVHEGN---QRWDNL 2616
C LE K RR++ +++ D L +M+ + + WD
Sbjct: 5756 TTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQC 5815
Query: 2617 QKRVTSILRRLKHFIGQREE---------------FETARDSILVW------LTEMDLQL 2655
+K++ + RL+ Q E+ + S+ W L M L
Sbjct: 5816 EKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADL 5875
Query: 2656 TNIEHFSECDVQAKIKQLKAFQQE-------ISLNHNKIEQIIAQGEQLIEKSEPLDAAI 2708
T H DV +Q++ ++ +++ +IE + EK++ L A +
Sbjct: 5876 T--RHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
Query: 2709 --------------IEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDE---HDLSDREL 2751
IEE +++L++ C E + + + ++L D+ R
Sbjct: 5934 VQMENKVLQTADISIEEMIEKLQKDCME---EINLFSENKLQLKQMGDQLIKASNKSRAA 5990
Query: 2752 ELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDH 2811
E++D + W D + S + + Q L S T + L
Sbjct: 5991 EIDDKLNKINDRW-QHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPV 6049
Query: 2812 DYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSA-LESQIRQLGKALDDSR 2870
YD+ D E A E ++ Q D + HSA +ES L DS
Sbjct: 6050 VYDVCDDQEIQKRLA---EQQDLQRDIE-----------QHSAGVESVFNICDVLLHDSD 6095
Query: 2871 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 2930
+TE S T LD ++ + E I+ RL K ++ +
Sbjct: 6096 ACANETE--CDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDW-- 6151
Query: 2931 LHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQL 2990
L S E +TA + E+L A K+ L++++ F ++ E+L
Sbjct: 6152 LKSAE-RTAACPNSSEVLYTSA-------KEELKRFEAFQRQIH-------------ERL 6190
Query: 2991 QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-DLQDRLS 3049
+LEL I Q ++L ++E+R D RL
Sbjct: 6191 TQLEL------INKQYRRL----------------------------ARENRTDTASRLK 6216
Query: 3050 QM----NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 3105
QM N RWD + + L+ Q + F +L+ L +D + + S
Sbjct: 6217 QMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHF-S 6275
Query: 3106 NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNR 3165
DA+ D +QL + E+ + ++ L QL+ +E D + ++++ +
Sbjct: 6276 ESDAD---DKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY 6332
Query: 3166 LKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRG 3225
+ + VSR + L +++ S + E R +P+
Sbjct: 6333 CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGESEEPSSPQS 6392
Query: 3226 KCSLSQPGPSVSS--------------PHSRSTKGGSDSSLSEPGP 3257
C L PG S H+ G S E GP
Sbjct: 6393 LCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGP 6438
Score = 92.0 bits (227), Expect = 9e-18
Identities = 369/2091 (17%), Positives = 813/2091 (38%), Gaps = 317/2091 (15%)
Query: 26 GKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ 85
G+ TEL Q + + + + Q + L+EY + E+ +++ T
Sbjct: 1973 GEKTELFCQALARKREQFESVAQLNNSLKEYG--------FTEEEEIIMEATC------- 2017
Query: 86 LREQYILHQTLLEESKEIDSELEAMTEKLQYLTS-----VYCTEKMSQQVAELGRETEEL 140
L ++Y QTLL + EI+ E + + + Q ++ +++ + + L + E
Sbjct: 2018 LMDRY---QTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLN--SSEG 2072
Query: 141 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS---------LKE 191
+ ++ R+Q +++ + +A ++ + E ++A L + +S
Sbjct: 2073 KMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAST 2132
Query: 192 QLSHRQHLLSEMES--------------LKPKVQAVQLCQSALRIPEDVVASLPLCHAAL 237
LSH++ LL E E LK K +A Q L ++ A L + L
Sbjct: 2133 YLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGL---QEKKAQLKIYKKFL 2189
Query: 238 RLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQE 297
+ ++ + L Q N + E+ ++ L E ++++D ++Q
Sbjct: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQD------SVQN 2243
Query: 298 LQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMK-AKHATMLLTVTEVEGLAEGTEDLD 356
L + H+ YQ + LN+ + + + + VE + ++L+
Sbjct: 2244 LDGHVREHDS-------YQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELE 2296
Query: 357 GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 416
L ++ + + T G++ +I S C+ + N AS
Sbjct: 2297 NRLSLQDGTLKKILALAKS-----VKQNTSSVGQKIIKDDIKSLQ-CKQKD-LENRLASA 2349
Query: 417 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVIS 476
Q++ E K ST +F PG E AT+ + + + ++ +
Sbjct: 2350 KQEM--------ECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEE 2401
Query: 477 EKQRTLYEALERQQKYQDSLQSI-STKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL 535
+ + A+E Q SL + S K E K++E ++Q L + +
Sbjct: 2402 DWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNE------------LQNQPLELDTM 2449
Query: 536 MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK 595
+ +++ E++ L +L ++ P EQ + A + I A LL+
Sbjct: 2450 LRNEQLEEIEK-LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQAL 2508
Query: 596 LNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLV 655
+ + ++ Q L+ ++ ++S S KA L S P+D L + +
Sbjct: 2509 ITLKKNKESQYCVLRDFQEYLAAVES---SMKALLTDKESLKVGPLDSVTYLDKIKKFIA 2565
Query: 656 EIEQKVVALSELSVHNENLLLEGKAHTKD-EAEQLAGKLRRLKGSLLELQRALHDKQLNM 714
IE++ +L L + ENL H D + + L ++++L+ ++++ + K
Sbjct: 2566 SIEKEKDSLGNLKIKWENL----SNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY--- 2618
Query: 715 QGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRS 774
+Q+ E D T Q QQ+Q LQ + + +E A +S+
Sbjct: 2619 ---SQQVVEYDEFTTLMNK-------VQDTEISLQQQQQHLQLRLKSPEERAGNQSM--- 2665
Query: 775 VASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED---QMRMKWES---LHQ 828
+A + +H + G A ++ + + E EK + ED ++ +WE+ LH
Sbjct: 2666 IALTTDLQATKHGFSVLKGQA----ELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
Query: 829 EFSTKQKLLQNVLEQEQEQVLYSRP--NRLLSGVPLYKGDVPTQ-------------DKS 873
E + K ++ + +E +L+++ L +PL D+ +Q +
Sbjct: 2722 EAENQIKKC-DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQ 2780
Query: 874 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDD-----VEER---- 924
+V SL + + +++ G ++ + Y + ST +EER
Sbjct: 2781 SVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFF 2840
Query: 925 -LFVATALLPEETETCLFNQ-----------------EILAKDIKEMSEEMDKNKNLFSQ 966
+ L+ +E+ET + + E K+++E+ + + +
Sbjct: 2841 AIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTN 2900
Query: 967 AFPE-NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLA 1025
+ E N R +ED L L R + + + C++++ K+ F
Sbjct: 2901 IYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH------------KIKFCRQF 2948
Query: 1026 DNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS 1085
K LQ+ A+ ++ ++ Q+ G+KE E+ D+L + + ++
Sbjct: 2949 HEKTSALQEEADSIQR---NELLLNQEVNKGVKE------EIYNLKDRLTAIKCCILQVL 2999
Query: 1086 KLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE 1145
KL+ ++D + + S L+Q T + E+ L++ L+T +E+ G + ++S
Sbjct: 3000 KLKKVFDYIG--LNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEE-HGKYQALLSKMR 3056
Query: 1146 EIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRG 1205
I + K E + L +I+S ++K E++ + + +
Sbjct: 3057 AIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNE--NKTFDDS 3114
Query: 1206 VELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNE 1265
+ + IL+ + + +E + +V+++ + + E +E D++ H+ LN+
Sbjct: 3115 FKEKEILQ----IKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHV---LNQ 3167
Query: 1266 YQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 1325
+ +L Q LLI++ ++++ + E + + + I K
Sbjct: 3168 IKSQLQQ------PLLINLEIKHIQNEKDNC-EAFQEQVWAEMCSIKAVTAIEKQREENS 3220
Query: 1326 SESADLIHWLQSAKDRLEFWTQQSVTV-PQELEMVRDHLNAFLE-FSKEVDAQSSLKSSV 1383
SE++D+ L+ +D L+ S+ + L ++L + E ++ V++ +SL++ +
Sbjct: 3221 SEASDVETKLREFED-LQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAII 3279
Query: 1384 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQM-----DKLPSRH 1438
+ +VD L + +L + + +Q+ +L M KL ++
Sbjct: 3280 IP--------YRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQY 3331
Query: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ E++S S M+ + E + YL+ YK C + + + ++
Sbjct: 3332 TLQELVSKNSAMKEAFKAQETEAE---------RYLENYK-------CYRKMEEDIYTNL 3375
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLE-----GLLESWSEYEN 1553
++ + +S S + E L + +S ++ L++ K +L++ LL +
Sbjct: 3376 SKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND 3435
Query: 1554 NVQCLKTWFETQEKRLKQQHRIGDQASVQNALKD----CQDLEDLIKAKEKEVEKIE--- 1606
+ LK EK L S+ A K+ C++L+ K +E+E+
Sbjct: 3436 GICLLKIVSALWEKWL----------SLLEAAKEWEMWCEELKQEWKFVSEEIEREAIIL 3485
Query: 1607 ---QNGLALIQNKKEDVSSIVMSTLRE-LGQTWANLDHMVGQLKILLKSVLD----QWSS 1658
Q L I KE ++ +S L + L Q N++ L +LL+ + SS
Sbjct: 3486 DNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
Query: 1659 HKV----AFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKF 1714
V AF +I S L + + + E VQ ++ + ++ + Q+
Sbjct: 3546 GAVETVPAFQEITSMKERCNKLLQK---VQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602
Query: 1715 GSITNQLLKECHPPVT---ETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 1771
+ + + HP + E L + LK+ + + N++E++ +++ S+ + +
Sbjct: 3603 TTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKL--RIKYSEMYTIVPAEIESQ 3660
Query: 1772 SKQCASTVQQQEDR-TNELLKA----ATNKDIAD-----DEVATWIQDCNDLLKGLGTVK 1821
++C ++ +++ +NE+LK+ A + I + V +Q + ++ ++
Sbjct: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
Query: 1822 DSLFFLHELGEQLKQQVDASAASAIQSD-----------QLSLSQHLCALEQALCKQQTS 1870
++ +L ++D+ ++ D + Q+ ++A C+ +
Sbjct: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECR-TSQ 3779
Query: 1871 LQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP-----SHSSDLSTIQERMEELKGQML 1925
L + E ++ L++ EAWI +L + S ST+Q +E+ + +
Sbjct: 3780 LNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHN 3839
Query: 1926 KFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 1976
S+ DL+ L+ + D+ + +Q L+ + + + E ++Q
Sbjct: 3840 LLHSIFMDLEDLSIIFE----TDELTQSIQELSNQVTALQQKIMESLPQIQ 3886
Score = 90.9 bits (224), Expect = 2e-17
Identities = 420/2300 (18%), Positives = 883/2300 (38%), Gaps = 390/2300 (16%)
Query: 1106 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 1161
NQN+ ++E+ ++ TGQ K+A D + ++ E E + +LD+
Sbjct: 713 NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
Query: 1162 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 1218
+T + + + K + F ELMA++ +L+ + +++L T
Sbjct: 762 ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
Query: 1219 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 1278
+ + Q+ VV+ L + + D +D + + L Y + Q+L +
Sbjct: 815 KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
Query: 1279 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 1333
S +L S+ + +SNT ++K L +E + + T + +S D+
Sbjct: 873 ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
Query: 1334 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 1393
+S L + QQ + + E + D++ L+ K+++ + L +
Sbjct: 925 KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
Query: 1394 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 1453
++ T L E S+ L + E L +L ++LPS+ + EV L+++
Sbjct: 968 RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
Query: 1454 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 1513
QK E +K + IH LQ G N +T + +S
Sbjct: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
Query: 1514 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 1559
T+ A + +L+ L E I + LLE + Y +NN +
Sbjct: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
Query: 1560 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 1619
+ F ++E R + +Q L D Q +++ A+ KE E I + + K+
Sbjct: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
Query: 1620 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 1678
TL+E + L+ + L+ L+ VL K + S L + ++
Sbjct: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
Query: 1679 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 1738
F L+ +A ++ +L+N+QD + KQ + N +LKE HP + N +
Sbjct: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
Query: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 1798
+ ++ + + + KAL +D+ + E T+ +A++ +
Sbjct: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
Query: 1799 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 1855
A + T + L+K D + ++ + ++ D S + + + + LS+
Sbjct: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
Query: 1856 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 1908
H +++ ++ L+A + K+++ +++ I + + +DP+
Sbjct: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
Query: 1909 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 1968
L + + ++E + + MA L + G +N ++ + L + + ++
Sbjct: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
Query: 1969 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 2025
E+ ++ L Q+Q F ++ + L+Q E+ + + + +Y ++L ++ E+ +
Sbjct: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
Query: 2026 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 2082
E ++ ++ + + Q L + + + F + ++ ++W + + + +
Sbjct: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
Query: 2083 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 2142
+ W + + + +W + + L Q T D + KE++ + +Q
Sbjct: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
Query: 2143 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 2196
+ + + L S LQ + I K + L + A L
Sbjct: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
Query: 2197 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 2252
+D ++ + I + L+ S + EE+ + ++ K LEN +G T +L
Sbjct: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
Query: 2253 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 2312
++L +++S + N + +LQ + +L + + N+W FS
Sbjct: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
Query: 2313 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 2367
L E E+K S +E+ ++KL E + +KI+ L+ + + L
Sbjct: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
Query: 2368 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 2424
KA + S + E++L K+ + AR K+L+++L + +L + +LR W
Sbjct: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
Query: 2425 LAHIE------------------------------------------SELAKPIVYDSCN 2442
L + E +E + I+ +C
Sbjct: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
Query: 2443 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 2502
+ Q L + E++ + + T S +L ++H + + L+
Sbjct: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
Query: 2503 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 2551
R + I + E +IE + L QK L D S W + + + S
Sbjct: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
Query: 2552 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 2594
G Y +KE ELKK + A Q + E QL++ K ++
Sbjct: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
Query: 2595 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641
D LK++ +GN + W ++ S+L++L+ + +
Sbjct: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
Query: 2642 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 2692
DS V +T+++ L N E S D V+ K+++L+ + +SL +++I+A
Sbjct: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
Query: 2693 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 2735
+ + + + + II++++ L+ C + +R +K
Sbjct: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
Query: 2736 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 2792
+ LP E SD + ++SAA+ L W + + DS + S LSL+ + +++
Sbjct: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
Query: 2793 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 2841
R + + PLE D L LE+ + P E E + +
Sbjct: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
Query: 2842 LRGAVGLSGDH-SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 2900
+ +G S H L + L K + ++ + + + + L T +
Sbjct: 2490 VLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG 2549
Query: 2901 LGECSSSIDSVKRLEHKLKEEEESLPGF------VNLHST-------ETQTAGVIDRWEL 2947
+ + +D +K+ +++E++SL ++ H T E+Q + WE
Sbjct: 2550 PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQ 2609
Query: 2948 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 3007
++ Q K Q + ++ +F + +N + DTE L+Q Q+ LQ+
Sbjct: 2610 VEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ----------HLQL- 2651
Query: 3008 KLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKESRDLQDRLSQMNG 3053
+LK ++ ++ I L+ +L + + QA+ KE ++L+D ++ +
Sbjct: 2652 RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKK 2711
Query: 3054 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ 3113
+W+ LE ++ + +C ++M +L +N+ N +P+ L +IL
Sbjct: 2712 QWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSIPL---LPDDILS 2763
Query: 3114 DHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKEKVHVIGNRLKLL 3169
K ++ H+ +L Q V SL + L EG+D E + N+ ++L
Sbjct: 2764 QIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLR---NQYQML 2818
Query: 3170 LKEVSRHIKELEKLLDVSSS 3189
+ + ++ ++LE L+ S+
Sbjct: 2819 VLKSTQRSQQLEFKLEERSN 2838
Score = 85.1 bits (209), Expect = 1e-15
Identities = 363/1901 (19%), Positives = 732/1901 (38%), Gaps = 302/1901 (15%)
Query: 756 QQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLS--QELG---MEG 810
+ QKELE + + LL S GE ++ +H A + L +EL E
Sbjct: 852 ESQKELESYMMRAQQLLGQRESPGE-LISKHKEALIISNTKSLAKYLKAVEELKNNVTED 910
Query: 811 EKSSAEDQMR---MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDV 867
K S E++ R KWESLH E S + L+ +E+ +L + + +
Sbjct: 911 IKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEK----------GKLSDNILKLEKQI 960
Query: 868 PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLE--QKLYDGVSATST------WLD 919
+ K GL + E S+ G + + H+E ++L + + + + L
Sbjct: 961 NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020
Query: 920 DVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR---- 975
D E+++ E T +K+ ++ ++ + S+A DN+
Sbjct: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080
Query: 976 DVIEDTLGCLLGRL-------SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNK 1028
+E T+ L + S+++ + + + ER + +L L +NK
Sbjct: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLER------YDTYRDILEHHLQNNK 1134
Query: 1029 YIILQKLANVFE------QPVAEQIEAIQQAEDG-LKEFDAGIIELKRRGDKLQVEQP-S 1080
+ I ++ + Q ++ I+ D KEF+ II LK +++P
Sbjct: 1135 FRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFE--IISLKLENHVNDIKKPFV 1192
Query: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
++E L++ EL M + +R L L L E+ A LL G +
Sbjct: 1193 IKERDTLKERERELQMTLNTRMESLETALRLVLPVEK-----ASLLLCGSD--------- 1238
Query: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKI--ISFAVQKETQFHTELMAQASAVL 1198
L HK QG H+I + +++ + I ++ K+ + L + VL
Sbjct: 1239 ----------LPLHKMAIQGF--HLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVL 1286
Query: 1199 KRAH------KRGVELEY--ILETWSHLDEDQQELSRQLEVVESSIPSVGL-VEENEDRL 1249
K H + + L+Y E +H + ++ + LE +S+ + L E D
Sbjct: 1287 KELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLS 1346
Query: 1250 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRL-----LISISCSDLESQLNQLGECWLSNT 1304
+ Q ++ + +++ + D K L ++ +S D E + E L
Sbjct: 1347 ASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAF 1406
Query: 1305 NKMSKELHRLETILKHWTRYQS-------ESADLIHWLQSAKDRLEFWTQQSVTVPQELE 1357
+ E H + + +T ++ +L+ +Q + ++ + TVP
Sbjct: 1407 SIKLSETHGY-GVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVP---- 1461
Query: 1358 MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQW----- 1412
V+ + + K +D K + N L K T+ + W
Sbjct: 1462 AVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKA 1521
Query: 1413 --TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG---- 1466
T+ L V E L Q Q K I + S ISL + + K +N+K I
Sbjct: 1522 LVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGK--ENLKKRIAEIEI 1579
Query: 1467 -YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESK--------RSDKT-DF 1516
+ +E+L+ KI+ CK L + + E+ ++KT D+
Sbjct: 1580 VKEEFNEHLEVVD--KINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDY 1637
Query: 1517 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 1576
E LG W +K+ L+ +++ W+E L E +RLK++ ++
Sbjct: 1638 YENLGRALALW--------DKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVH 1689
Query: 1577 DQASVQNALKDCQDLEDLIKAKE--KEVEKIEQNGLALIQNKKEDVSS---------IVM 1625
+Q + + + + +++ L+++ E E++ +E + I NK E V +
Sbjct: 1690 EQKTSEFS-RRVAEIQFLLQSSEIPLELQVMESS----ILNKMEHVQKCLTGESNCHALS 1744
Query: 1626 STLRELGQTWANLDHMVGQLKILLKSVLDQWSSH-KVAFDKINSYLMEARYSL----SRF 1680
+ EL + +G + LLK++ S ++I +++ ++S+ ++
Sbjct: 1745 GSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQI 1804
Query: 1681 RLLTGSLEAVQVQVDNLQN--------LQDDLEK----QERSLQKFGSITNQLLKECHPP 1728
LT L ++ Q +++ + LQD K Q ++ + S LKEC
Sbjct: 1805 GCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFES 1864
Query: 1729 VTETLTNTLKEVNMRWNNLLEEIAEQLQSSK-----ALLQLWQRY--KDYSKQCASTV-- 1779
+ T K V + L + + + ++SK ++L+ +++ K + K+ S +
Sbjct: 1865 -----SETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVG 1919
Query: 1780 QQQEDRTNELLKAATNKDIAD--DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQ 1837
Q+ E E + A K++ D ++ D +L K L ++ + E GE+ +
Sbjct: 1920 QEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
Query: 1838 VDASAASAIQSDQL-----SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 1892
A A Q + + SL ++ E+ + + T L Y+T + L +E
Sbjct: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMD---RYQTLLRQLSEIE--- 2033
Query: 1893 VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSS------MAPDLDRLNELGYRLPL 1946
E +++L +D S + + ++E+K ++ +S + + ++ E+ P
Sbjct: 2034 -EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPE 2092
Query: 1947 NDKEI----------------KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990
D I K + +++ W + S + LL+ + +L+ E
Sbjct: 2093 GDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKE 2152
Query: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG- 2049
L++ ++K E QH L++++A + + Q L S++ + L QG
Sbjct: 2153 DLRLMLIELKKK--QEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLL---KELKSQGN 2207
Query: 2050 ---QVDDRDEFNLKLTL-LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE 2105
+ F+ + L + + + ++++ Q +D +R+ Y+ L L
Sbjct: 2208 YLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDN 2267
Query: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAG--KQLLLSADSGA 2163
S +S P+ D++ +EK+ Q+ L+++ G K++L A S
Sbjct: 2268 FSKEFVS-FSDKPV---------DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVK 2317
Query: 2164 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223
+ I++ KS + ++ + +LA ++ E C I L+ R+ +KK +
Sbjct: 2318 QNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI---LKSKRSTEKKGKFT 2374
Query: 2224 LPDHHEELHAEQMRCKELENAVGSWTDD--LTQLSLLKDTLSAYISADDISIL-----NE 2276
LP ++ ++ + AV +D + + S ++ +S +S + +
Sbjct: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
Query: 2277 RVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK-----ELCEWLTQMESKV---- 2327
+V LQ Q EL LR +Q+ E + K E E L + E+
Sbjct: 2435 KVNELQNQPLEL--DTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLH 2492
Query: 2328 -----SQNGDILIEEMIEKLK---------KDYQEEIAIAQENKIQLQQMGERLAKASHE 2373
+Q+ D L++ +I K +D+QE +A + + L E L +
Sbjct: 2493 NIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLD 2552
Query: 2374 SKA---------SEIEYK---LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 2421
S + IE + LG + +W++L + + KKL E+ ++QL+
Sbjct: 2553 SVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLES--QIKQLEHG---- 2606
Query: 2422 RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK 2462
W +E ++ K +E +N+ Q+ + +++
Sbjct: 2607 --W-EQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQ 2644
Score = 73.9 bits (180), Expect = 2e-12
Identities = 322/1774 (18%), Positives = 692/1774 (39%), Gaps = 283/1774 (15%)
Query: 1451 ENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKR 1510
EN++ + + GY E+ ++ K + I F N +L+ + QDV+S+
Sbjct: 1400 ENLLDAFSIKLSETHGYGVQEEFTEENKLLEACI--------FKNNELLK-NIQDVQSQI 1450
Query: 1511 SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQ----CLKTWFETQE 1566
S ++G + + ++ I+L + +L+ + E + ++Q L + + +E
Sbjct: 1451 S-------KIGLKDPTVPAVKHRKKSLIRL-DKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
Query: 1567 KRLKQQHRI------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620
K + QQ + +A V L+ C + +L+K + + + LIQ K+E V
Sbjct: 1503 KTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLK----QYQNFKSILTTLIQ-KEESV 1557
Query: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680
S+ S + + NL + +++I V ++++ H DKIN ++ L++
Sbjct: 1558 ISLQASYMGK-----ENLKKRIAEIEI----VKEEFNEHLEVVDKINQVCKNLQFYLNKM 1608
Query: 1681 RLLTGSL--EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 1738
+ + + VD ++ + E +L + ++ ++L + E L+
Sbjct: 1609 KTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFN-LKNVIDEWTEKALQ 1667
Query: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAST--VQQQEDRTNELL---KAA 1793
++ + + L EE E+L+ + + Q+ ++S++ A + Q + EL +
Sbjct: 1668 KMEL--HQLTEEDRERLKEELQVHE--QKTSEFSRRVAEIQFLLQSSEIPLELQVMESSI 1723
Query: 1794 TNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA---SAIQSDQ 1850
NK + T +C+ L +++ L +Q K Q+ + + + SD
Sbjct: 1724 LNKMEHVQKCLTGESNCHALSGSTAELREDL-------DQAKTQIGMTESLLKALSPSDS 1776
Query: 1851 LSLSQHLCALEQALCKQQTSL-----QAGVLDYET--FAKSLEALEAWIVEAEEILQGQD 1903
L + L ++Q + +Q+ S+ Q G L E K E++ + +LQ
Sbjct: 1777 LEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHF 1836
Query: 1904 PSHSSD--------LSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQ 1955
+D S I+ ++E S+ L +L++ L + +IK++
Sbjct: 1837 SKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDF-LTLEGRNSKIKQVD 1895
Query: 1956 NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLL 2015
++ +H + +L S+L+ + LEK ME + Q K E+ + Q LL
Sbjct: 1896 SVLKH--VKKHLPKAHVKELISWLVGQEFELEK----MESICQARAK---ELEDSLQQLL 1946
Query: 2016 EQQRAH------------------------ELFQAEMFSRQQILHSIIIDGQRLLEQGQV 2051
Q H ELF + +++ S+ L E G
Sbjct: 1947 RLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFT 2006
Query: 2052 DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPM 2111
++ +E ++ T L +++Q ++R+ + + Q + ++A + W+ E+ M
Sbjct: 2007 EE-EEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLM 2065
Query: 2112 ---SGLGSVPIPLQQARTLFDEVQ-FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAAL 2167
S G +P+ + +Q KE + L+ +G + + ++ A+S +
Sbjct: 2066 VLNSSEGKMPLE--------ERIQKIKEIILLKPEGDARI-----ETIMKQAESSEAPLV 2112
Query: 2168 QAELAEIQEKWKS----ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223
Q L +I +W + AS L Q+K LL + EK + D L KKK
Sbjct: 2113 QKTLTDISNQWDNTLHLASTYLSHQEK----LLLEGEKYLQSKEDLRLMLIELKKKQEAG 2168
Query: 2224 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 2283
H L ++ + K + + DLT SLLK+ S + + + +
Sbjct: 2169 FALQHG-LQEKKAQLKIYKKFLKK-AQDLT--SLLKELKS---QGNYLLECTKNPSFSEE 2221
Query: 2284 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 2343
W E+ H QQ+ + + ++ +T + + + D +E +
Sbjct: 2222 PWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL----DNFSKEFVSFSD 2277
Query: 2344 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 2403
K + IA E K+Q K E+E +L + + +L L K
Sbjct: 2278 KPVDQ---IAVEEKLQ---------------KLQELENRLSLQDGTLKKILAL----AKS 2315
Query: 2404 LKETLVAVQQ--LDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 2461
+K+ +V Q + ++ SL+ +E+ LA +E++ LN + +R E
Sbjct: 2316 VKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASA-------KQEMECCLNSILKSKRSTE 2368
Query: 2462 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQ--ATRNLDRRWR----NICAMSMERR 2515
K + L + AT +S Q+ A L+ W + M+M ++
Sbjct: 2369 KKG----------KFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQ 2418
Query: 2516 LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE 2575
L + + ED K +E ++ EE++K
Sbjct: 2419 LSLNAQ--------ESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKL--------- 2461
Query: 2576 CLTQLELINKQYRRLARE---NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIG 2632
TQLE + L + N+T++ + + Q DNL + + ++ + +
Sbjct: 2462 -YTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
Query: 2633 QREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKAFQQEISLNHNKIEQI 2690
+F+ + + + M LT+ E D + ++K F I + + +
Sbjct: 2521 VLRDFQ---EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
Query: 2691 IAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRE 2750
+ E L +D ++E ++ +L ++V ++++ + S +
Sbjct: 2578 KIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY---------------SQQV 2622
Query: 2751 LELEDSAALSDLHWHDRSADSLLS-PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEW 2809
+E ++ L + + D+ +S Q +L L L P ER+G + ++ +
Sbjct: 2623 VEYDEFTTLMN-----KVQDTEISLQQQQQHLQLRLKSP--EERAGNQSMIALTTDLQAT 2675
Query: 2810 DHDYD-LSRDLESAMSRALPSEDEEGQDDKDFYLRGA-VGLSGDHSALESQIRQLGKALD 2867
H + L E M R ++++ +D L+ L H E+QI++
Sbjct: 2676 KHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKC----- 2730
Query: 2868 DSRFQIQQT----ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV----KRLEHKLK 2919
D R ++++T +N++ P+ P L ++ +C + D + + +E +
Sbjct: 2731 DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIR---KCKVTHDGILARQQSVESLAE 2787
Query: 2920 EEEESLPGFVNLHSTETQTA--GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW 2977
E ++ +P ++ + +++++L ++ + +++ L++ F + +
Sbjct: 2788 EVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
Query: 2978 AWLGDTEEEL-----EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 3032
+ ++E + EL T+E K+L+E+ + + +I
Sbjct: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNI------ 2901
Query: 3033 FTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 3092
+ + + E L+D+L + R +R+ ++ ++ + C+ FHE + L ++
Sbjct: 2902 YEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADS 2961
Query: 3093 IDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 3126
I R NE++ L+ E+ + +++ +K L
Sbjct: 2962 IQR--NELL-----LNQEVNKGVKEEIYNLKDRL 2988
Score = 72.8 bits (177), Expect = 5e-12
Identities = 505/2870 (17%), Positives = 1040/2870 (36%), Gaps = 420/2870 (14%)
Query: 28 LTELHQQTIRQAENRLSK-------LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 80
L ELH + +N + K +N E+ + LE L + AK+ A
Sbjct: 1286 LKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDL 1345
Query: 81 NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRET--E 138
+++ Q TL ++KE E+ M +K ++L MS + AE G +T E
Sbjct: 1346 SASDT---QVAQENTLTVKNKE--GEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCE 1400
Query: 139 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQH 198
L I+L ++F E K L+A + + L + + Q
Sbjct: 1401 NLLDAFSIKLSETHGYGVQ-EEFTEENKLLEACIFKNNELL-----------KNIQDVQS 1448
Query: 199 LLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQH-------TAI 251
+S++ P V AV+ + +L + V+ LQE A+ L H T
Sbjct: 1449 QISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYE--EEKRHLQEMANSLPHFKDGREKTVN 1506
Query: 252 QQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQK 311
QQC Q VV +E + + + E Q R EL ++
Sbjct: 1507 QQC---QNTVVLWENTK------------------------ALVTECLEQCGRVLELLKQ 1539
Query: 312 IKGYQEQIASLNSKCK-MLTMKAKHA---TMLLTVTEVEGLAEGTEDLDGELLPTPSAHP 367
+ ++ + +L K + +++++A + + + E+E + E + H
Sbjct: 1540 YQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNE-----------HL 1588
Query: 368 SVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIA-YYQAL 426
VV C L + + E PP + + + + +N+ YY+ L
Sbjct: 1589 EVVDKINQVCKNLQFYLNKMKTFE-------EPPFEKEANIIVDRWLDINEKTEDYYENL 1641
Query: 427 SAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEAL 486
D K+ + E+ E L+ +L + R E LK + ++ E
Sbjct: 1642 GRALALWD--KLFNLKNVIDEWTEKALQKMELHQLTEEDR--ERLKEELQVHEQKTSEFS 1697
Query: 487 ERQQKYQDSLQS--ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINEL 544
R + Q LQS I +++ +E + E + + + AL L++++++
Sbjct: 1698 RRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQA 1757
Query: 545 --QSSLAEELVSESCEADPAE----------QLALQSTLTVLAERMSTIRMKASGKRQLL 592
Q + E L+ +D E Q+ Q +L E + +
Sbjct: 1758 KTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQ 1817
Query: 593 EEKLNDQLEEQR---QEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD 649
E ++D ++ Q+ + + + W + K L + +E +L
Sbjct: 1818 YESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQK 1877
Query: 650 CQNMLV------EIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 703
+ L +I+Q L + H KAH K+ L G+
Sbjct: 1878 LSDFLTLEGRNSKIKQVDSVLKHVKKHLP------KAHVKELISWLVGQ----------- 1920
Query: 704 QRALHDKQLNMQGTAQEKEESDVDLTATQSP--GVQEWLAQARTTWTQQRQSSLQQQKEL 761
+ L + Q A+E E+S L Q +++WL W + ++ +
Sbjct: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPG-EKTELF 1979
Query: 762 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRM 821
Q LA ++ SVA + +E G + E+++ M
Sbjct: 1980 CQALARKREQFESVAQLNNSL---------------------KEYGF-----TEEEEIIM 2013
Query: 822 KWESLHQEFSTKQKLLQNVLEQE-----QEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVT 876
+ L + T + L + E++ ++Q + ++ + K + + S
Sbjct: 2014 EATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGK 2073
Query: 877 SLLDGLNQAFEEVS--SQSGGAKRQSIHLEQKLYDGVSATSTWLD---DVEERLFVATAL 931
L+ Q +E+ G A+ ++I + + + T D + L +A+
Sbjct: 2074 MPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTY 2133
Query: 932 LPEETETCLFNQEILA--KDIKEMSEEMDKNKNL---FSQAFPENGDNRDVIEDTLGCLL 986
L + + L ++ L +D++ M E+ K + E + + L
Sbjct: 2134 LSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ 2193
Query: 987 GRLSLLDSVVNQRCHQMKERLQQILNFQN--DLKVLFTSLADNKYIILQKLANVFEQPVA 1044
SLL + +Q + ++ + + ++K L SL +Q L + +
Sbjct: 2194 DLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDS 2253
Query: 1045 EQIEAIQQAEDGLKEFDAGIIELKRRG-DKLQVEQPSMQELSKLQDMYDELMMIIGSRRS 1103
Q+ + L F + + D++ VE+ +L KLQ++ + L +
Sbjct: 2254 YQV-CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEE----KLQKLQELENRLSL------- 2301
Query: 1104 GLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES 1163
Q+ TLK A + GQ+ + D K + +++++ L K+ + +
Sbjct: 2302 ---QDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLN 2358
Query: 1164 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ 1223
++ ++ K F + + QA++ ++ + + +E + E W +
Sbjct: 2359 SILKSKRSTEKKGKFTLPGREK-------QATSDVQESTQESAAVEKLEEDWEINKDSAV 2411
Query: 1224 ELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLIS 1283
E++ ++ S+ + ++ ED + +NE Q + ++ +L +
Sbjct: 2412 EMAMSKQL---SLNAQESMKNTED------------ERKVNELQNQPLEL----DTMLRN 2452
Query: 1284 ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLE 1343
++E QL K L + E + K T A ++H + + L+
Sbjct: 2453 EQLEEIEKLYTQL-----EAKKAAIKPLEQTECLNKTET-----GALVLHNIGYSAQHLD 2502
Query: 1344 FWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRS 1403
Q +T+ + E L F E+ V+ SS+K+ L T + L++ +D+ T
Sbjct: 2503 NLLQALITLKKNKESQYCVLRDFQEYLAAVE--SSMKA--LLTDKESLKVGPLDSVTYLD 2558
Query: 1404 ELSRIDS---QWTDLLTNIPAVQEKL--HQLQMDKLPSRHAISEVMSWISLMENVIQKDE 1458
++ + + + D L N+ E L H MDK I ++ +E IQK
Sbjct: 2559 KIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY 2618
Query: 1459 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAE 1518
+ + Y + K + +I + +Q + L++ S + +
Sbjct: 2619 S--QQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ------LRLKSPEERAGNQSMIALTT 2670
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK-RLKQQHRIGD 1577
L A + +L+G +++ + G E E+ + LK +ET E L+ +++I
Sbjct: 2671 DLQATKHGFSVLKGQAELQMKRIWGEKEK-KNLEDGINNLKKQWETLEPLHLEAENQI-K 2728
Query: 1578 QASVQNALKD-----------------------------CQDLEDLIKAKEKEVEKIEQN 1608
+ ++N +K+ C+ D I A+++ VE + +
Sbjct: 2729 KCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEE 2788
Query: 1609 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 1668
+ + S + +TL +L + L Q L+ L++ S+ K
Sbjct: 2789 VKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQL 2848
Query: 1669 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 1728
+ E+ +L R+ T + EA L++ LE ++ LQ+ S + L+E
Sbjct: 2849 MVQESE-TLIIPRVETAATEA------ELKHHHVTLEASQKELQEIDSGISTHLQE---- 2897
Query: 1729 VTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYS--------KQC----- 1775
LTN +E+N+ LE+ QL++ K QR+ + K C
Sbjct: 2898 ----LTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHE 2950
Query: 1776 -ASTVQQQED---RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 1831
S +Q++ D R LL NK + ++ I + D L + + L ++
Sbjct: 2951 KTSALQEEADSIQRNELLLNQEVNKGVKEE-----IYNLKDRLTAIKCCILQVLKLKKVF 3005
Query: 1832 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 1891
+ + D S +Q+ + L + KQ + + Y+ + A++
Sbjct: 3006 DYIGLNWDFSQLDQLQTQVFEKEKEL----EEKIKQLDTFEEEHGKYQALLSKMRAIDLQ 3061
Query: 1892 IVEAEEI-LQGQDPSHSS---DLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPL 1946
I + E+ L+ D S S + + +R+E+ K + + +LNE +
Sbjct: 3062 IKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI------IKKLNENKTFDDSF 3115
Query: 1947 NDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQ-------HQTFLEKCETWMEFLVQT 1999
+KEI +++ L + + + + LQ+ +L+ + +K ET + L Q
Sbjct: 3116 KEKEILQIK-------LNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQI 3168
Query: 2000 EQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSII-IDGQRLLEQGQVDDRDE 2056
+ +L + N + H+ ++ E FQ ++++ + ++ I+ QR + D +
Sbjct: 3169 KSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVET 3228
Query: 2057 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 2116
KL + + R +++ RY+E + + + + + +
Sbjct: 3229 ---KLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVD 3285
Query: 2117 VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQE 2176
V P + E+ +++ L ++I + ++ S + A+ LQ L E+
Sbjct: 3286 VGNPEESL-----EMPLRKQEELESTVAHIQDLTEKLGMISSPE--AKLQLQYTLQELVS 3338
Query: 2177 K---WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHA 2233
K K A E + ++ K + K E+ I +L K+ T + SLP + E
Sbjct: 3339 KNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALE 3398
Query: 2234 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
+ K L + + S ++L +L + L + +D L + V L +W L
Sbjct: 3399 RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAK 3458
Query: 2294 LRRQQIGERLNEWAVFSEKNKE---LCEWLTQMESKVSQNGDILIEEMIEKLKK---DYQ 2347
E EW SE+ + + + L + ++S+ + E + +L Y
Sbjct: 3459 EWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYG 3518
Query: 2348 EEIAIAQENKIQLQQMGERLAKASHESKASEIE---YKLGKVNDRWQHLLDLIAARVKKL 2404
E + Q L Q + S A E ++ + +R LL + + +
Sbjct: 3519 ENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELV 3578
Query: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD----SCNSEEIQR-----KLNEQQE 2455
+ + K + +L+ + + D S EE+Q KL +
Sbjct: 3579 QTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENI 3638
Query: 2456 LQRDIEKHS-------TGVASVLNLCEVLLHDCDACATDAECDS-----IQQATRNLDRR 2503
+++ K+S + S + C L D D ++ S +++ ++
Sbjct: 3639 MEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNG 3698
Query: 2504 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 2563
N+ M ++ IE+ + +K D+ + L + E
Sbjct: 3699 LHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----------------SEVQ 3742
Query: 2564 KKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI 2623
E Q E + L + +QY+++++ R + S + + +L K +
Sbjct: 3743 DIVEQDPGQAQEWMDNLMIPFQQYQQVSQ--RAECRTSQLNKATVKMEEYSDLLKSTEAW 3800
Query: 2624 LRRLKHFIGQREEFETARD-----SILVWLTEMDLQLTNIEH-----FSECDVQAKIKQL 2673
+ H + ++++ R S + E Q N+ H + + + +L
Sbjct: 3801 IENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDEL 3860
Query: 2674 KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV 2723
QE+S ++Q I + I++ D IE E+ + + ++
Sbjct: 3861 TQSIQELSNQVTALQQKIMESLPQIQRMAD-DVVAIESEVKSMEKRVSKI 3909
Score = 67.0 bits (162), Expect = 3e-10
Identities = 316/1695 (18%), Positives = 635/1695 (37%), Gaps = 300/1695 (17%)
Query: 1589 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 1635
+ L+ L+K E + + N L + +++ E+ S V+S R+L + W
Sbjct: 311 EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
Query: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 1695
LDH + KI L L A+ + LM+ S S+ + ++ +Q ++
Sbjct: 371 DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
Query: 1696 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 1751
++L D E L +T + E H P+ N L+E+ R NN+LE+ +
Sbjct: 429 LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
Query: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 1807
E +L L K SK ++ + ELL +K I + E + T
Sbjct: 482 LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
Query: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
Q C ++ K L A I + + +C + +
Sbjct: 540 QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
+++LQ + + T+ ++L L A E T +E ++E+ + L
Sbjct: 578 KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
Query: 1928 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 1981
++ + LNE G L ++ K ++ LN+ W + S+T + Q
Sbjct: 621 WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
Query: 1982 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 2037
Q + + + V+ ++VE+ NY ++ HE E + ++
Sbjct: 679 DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
Query: 2038 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 2097
D ++L+ Q ++ W+ + + ++D Q M E
Sbjct: 738 ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
Query: 2098 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 2157
L+ + + S +FDE+ + + L+ I + E+ + +L
Sbjct: 769 SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
Query: 2158 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 2217
+ LQA++ E +EK + ++L K L + D + K + +S ++L ++
Sbjct: 810 T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
Query: 2218 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 2277
+ Q L ++ K E + S T L + + L ++ D L E+
Sbjct: 862 MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
Query: 2278 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 2337
+ +WE L H+LSL QQ+ + EK K L + + ++E ++++ ++
Sbjct: 919 SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
Query: 2338 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 2396
+ L K++ E ++E + QL E L + E + + + ++ ++ ++ ++
Sbjct: 971 RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
Query: 2397 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 2456
+ +K E + +Q S + E+ P +SE K + Q
Sbjct: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
Query: 2457 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 2514
++ +E +ASVL L E + + D A SI D +R+I +E
Sbjct: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
Query: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 2574
L+ + + D+S ED +SS A + VI K+FE ++
Sbjct: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
Query: 2575 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 2634
+ I K + R+ + L+ + N R ++L+ + +L
Sbjct: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
Query: 2635 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 2694
+ S+L+ +++ L I+ F D + L+ Q I+ ++ G
Sbjct: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
Query: 2695 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 2754
++++ P D ++ + + + + + RV+R L
Sbjct: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
Query: 2755 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER-SGRDTPASVDSIPLEWDHDY 2813
AL D R+A LS +P ++LS S Q + + ++ + + + H
Sbjct: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD 1378
Query: 2814 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS-ALESQIRQLGKALDDSRFQ 2872
+ L+ + A +D ++ D + ++ LS H ++ + + K L+ F+
Sbjct: 1379 KCLKMLDMSFKDAERGDDTSCENLLDAF---SIKLSETHGYGVQEEFTEENKLLEACIFK 1435
Query: 2873 ----------IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 2922
+Q + I K PT P + K ++L +D + + L+E
Sbjct: 1436 NNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRL----DKVLDEYEEEKRHLQEMA 1491
Query: 2923 ESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELRMKQNLQKWQQFNSDLNSIW 2977
SLP F + + Q + WE L + L + R+ + L+++Q F S L +
Sbjct: 1492 NSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTT-- 1549
Query: 2978 AWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC--- 3029
L EE + LQ + L I IE+ ++ E + VD + ++
Sbjct: 1550 --LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607
Query: 3030 -----SPEFTQAD----------SKESRDLQDRLSQMNGRWDRVCSL---LEEWRGLLQD 3071
P F + ++++ D + L + WD++ +L ++EW +
Sbjct: 1608 MKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW----TE 1663
Query: 3072 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQL 3131
+Q H+++ E+ +R K E+ + + + +++ +I+ L S++
Sbjct: 1664 KALQKMELHQLTE------EDRERLKEEL-----QVHEQKTSEFSRRVAEIQFLLQSSEI 1712
Query: 3132 RVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKLLLKEVSRHIKELEKLLDVS 3187
+ LQ M +L E CL + H + L+ L + I E LL
Sbjct: 1713 PL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKAL 1771
Query: 3188 SSQQDLSSWSSADEL 3202
S L ++ +E+
Sbjct: 1772 SPSDSLEIFTKLEEI 1786
Score = 52.0 bits (123), Expect = 1e-05
Identities = 259/1388 (18%), Positives = 524/1388 (37%), Gaps = 207/1388 (14%)
Query: 18 GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW---IEKAKVLA 74
G L + L +Q + ++ R +L LEE + +I K+ +++++ L
Sbjct: 2801 GSDLNNTLEDLRNQYQMLVLKSTQRSQQLE---FKLEERSNFFAIIRKFQLMVQESETLI 2857
Query: 75 HGTIAWNSA-SQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY----CTEKM--S 127
+ + ++L+ ++ + +E +EIDS ++ LQ LT++Y E++
Sbjct: 2858 IPRVETAATEAELKHHHVTLEASQKELQEIDS---GISTHLQELTNIYEELNVFERLFLE 2914
Query: 128 QQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRL 187
Q+ L T +++ I+ ++ K ++F + LQ + Q L
Sbjct: 2915 DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRN-------EL 2967
Query: 188 SLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQE------ 241
L ++++ + + E+ +LK ++ A++ C + + V + L +L +
Sbjct: 2968 LLNQEVN--KGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVF 3025
Query: 242 EASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQ 301
E + I+Q + + +Y+ +M+ + I+ + P ++ + L AQ
Sbjct: 3026 EKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQ 3085
Query: 302 ISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATML---LTVTEVEGLAEGTEDLDGE 358
I + +K K ++I ++ K K +L L E + L + +++ E
Sbjct: 3086 IL--SQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLE 3143
Query: 359 LLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQ 418
L P + H L S++ P +N
Sbjct: 3144 LSPKELDEKNCQDKLETSLHVL----------NQIKSQLQQP-------------LLINL 3180
Query: 419 DIAYYQ------ALSAERLQTDAAKIHPSTSASQEFYEPGLEPS-ATAKLGDLQRSWETL 471
+I + Q E++ + I T+ ++ E E S KL + + L
Sbjct: 3181 EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL 3240
Query: 472 KNVISEKQRTLYEALERQQKYQDSL----QSISTKMEAIELKLS-ESPEPGRSPESQMAE 526
I + L +A E +Y++++ +SI T +EAI + + P S E + +
Sbjct: 3241 NTSIDLRTNVLNDAYENLTRYKEAVTRAVESI-TSLEAIIIPYRVDVGNPEESLEMPLRK 3299
Query: 527 HQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKAS 586
+ L + +QD L E+L S P +L LQ TL L + S MK +
Sbjct: 3300 QEELESTVAHIQD--------LTEKLGMIS---SPEAKLQLQYTLQELVSKNSA--MKEA 3346
Query: 587 GKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQ 646
K Q E E+ L+ Y+C +++ + + + ++T L M +
Sbjct: 3347 FKAQ-----------ETEAERYLENYKCYR-KMEEDIYTNLSKMETVLG-----QSMSSL 3389
Query: 647 LMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGS------- 699
+ + L +EQ +S L TK+E +L LR L+
Sbjct: 3390 PLSYREALERLEQSKALVSNL------------ISTKEELMKLRQILRLLRLRCTENDGI 3437
Query: 700 -LLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQ 758
LL++ AL +K L++ A+E E W + + W
Sbjct: 3438 CLLKIVSALWEKWLSLLEAAKEWEM---------------WCEELKQEW----------- 3471
Query: 759 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ 818
K + +E+ + +L ++ EI AA T + E D L Q G EK
Sbjct: 3472 KFVSEEIEREAIILDNLQEELPEISKTKEAATTE-ELSELLDCLCQ-YGENVEKQQLLLT 3529
Query: 819 MRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT--QDKSAVT 876
+ ++ Q ++ V ++ + R N+LL V K V T Q++ + T
Sbjct: 3530 LLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFT 3589
Query: 877 SLLDGLNQAFEEVSSQSGGAKRQSIHLE-----QKLYDGVSATSTWLDDVEERLFVATA- 930
+ L F++ ++ Q H E ++L + +++ E+L + +
Sbjct: 3590 KEIIALKNFFQQTTTSFQNMAFQD-HPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSE 3648
Query: 931 ---LLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLG 987
++P E E+ + +DI E K N ++ P R + E
Sbjct: 3649 MYTIVPAEIESQVEECRKALEDIDE------KISNEVLKSSPSYAMRRKIEE-------- 3694
Query: 988 RLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI 1047
+N H +++ LQQ + + + D + KL N + V + +
Sbjct: 3695 --------INNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKL-NELDSEVQDIV 3745
Query: 1048 EAIQ-QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLN 1106
E QA++ + + ++ + + + + + + Y +L+ + +
Sbjct: 3746 EQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTS 3805
Query: 1107 QNLTLKSQYE--RALQDLADLLETGQEKMAGDQKIIVSSKEEIQQL--LDKHKEYFQGLE 1162
L + Y+ R L A ++ E ++ S +++ L + + E Q ++
Sbjct: 3806 HLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQ 3865
Query: 1163 SHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 1222
L +KI+ Q + + +++A S V K KR +++ IL + D
Sbjct: 3866 ELSNQVTALQQKIMESLPQIQ-RMADDVVAIESEV-KSMEKRVSKIKTILLSKEIFDFSP 3923
Query: 1223 QELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
+E + EV+ +I + + I I YQ ++ L + K V +LL
Sbjct: 3924 EEHLKHGEVILENIRPM-------KKTIAEIVSYQ-VELRLPQTGMKPLPVFQRTNQLLQ 3975
Query: 1283 SISC-SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS------ESADLIHWL 1335
I ++ + N+L + + TN+ +E+ L+ IL +++ S + AD + L
Sbjct: 3976 DIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQL 4035
Query: 1336 QSAKDRLE 1343
Q +R+E
Sbjct: 4036 QGEIERME 4043
Score = 41.2 bits (95), Expect = 0.017
Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)
Query: 2945 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 3004
W LQ + L K L+ +N ++++NS L+ + ++ EE+ L L + D+ ++
Sbjct: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
Query: 3005 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 3060
+L+E +DH+ A + +N P T+A +E +L D + + +
Sbjct: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
Query: 3061 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 3120
L++E L + + + E +LL EN D +VP
Sbjct: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
Query: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 3168
++L E + R+ ++ + LL+ CL E K K+ + G+R ++L
Sbjct: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
Query: 3169 LLKEVSRHIKELEKLLDVSSSQQ 3191
LL++ + I+E E L + +S Q
Sbjct: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform 3
[Homo sapiens]
Length = 982
Score = 1890 bits (4895), Expect = 0.0
Identities = 959/982 (97%), Positives = 959/982 (97%), Gaps = 23/982 (2%)
Query: 2363 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 2422
MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR
Sbjct: 1 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
Query: 2423 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 2482
TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD
Sbjct: 61 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 2483 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 2542
ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
Query: 2543 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 2602
ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL
Sbjct: 181 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
Query: 2603 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 2662
KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS
Sbjct: 241 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
Query: 2663 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 2722
ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE
Sbjct: 301 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
Query: 2723 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 2782
VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS
Sbjct: 361 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
Query: 2783 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 2842
LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL
Sbjct: 421 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
Query: 2843 RGAVGL-----------------------SGDHSALESQIRQLGKALDDSRFQIQQTENI 2879
RGAVGL SGDHSALESQIRQLGKALDDSRFQIQQTENI
Sbjct: 481 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 540
Query: 2880 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 2939
IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA
Sbjct: 541 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 600
Query: 2940 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 2999
GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI
Sbjct: 601 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660
Query: 3000 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 3059
QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC
Sbjct: 661 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720
Query: 3060 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 3119
SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL
Sbjct: 721 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
Query: 3120 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 3179
MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE
Sbjct: 781 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
Query: 3180 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 3239
LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP
Sbjct: 841 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 900
Query: 3240 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 3299
HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA
Sbjct: 901 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 960
Query: 3300 LSNNFARSFHPMLRYTNGPPPL 3321
LSNNFARSFHPMLRYTNGPPPL
Sbjct: 961 LSNNFARSFHPMLRYTNGPPPL 982
Score = 72.0 bits (175), Expect = 9e-12
Identities = 60/358 (16%), Positives = 149/358 (41%), Gaps = 17/358 (4%)
Query: 2152 GKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE 2211
G++L ++ + ++ +L ++ ++W+ + + KKL L ++ +K ++
Sbjct: 2 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 2212 KLRTFKKKLSQSL-------PDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 2264
L + +L++ + + +L+ +Q +++E L +L A
Sbjct: 62 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 2265 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 2324
+ + + + L R+W +C RR +I E W F + +WL E
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
Query: 2325 SKVS--QNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIE 2380
+ + ++ E+LKK +Q ++ + + RLA+ + A ++
Sbjct: 182 RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK 241
Query: 2381 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 2440
+ + N RW +L + + +++LK + ++ + S+ WL ++ +L +
Sbjct: 242 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 301
Query: 2441 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL---HDCDACATDAECDSIQQ 2495
C ++Q K+ + + Q++I + + ++ E L+ DA + E D +++
Sbjct: 302 C---DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
Score = 70.1 bits (170), Expect = 3e-11
Identities = 153/829 (18%), Positives = 321/829 (38%), Gaps = 94/829 (11%)
Query: 1720 QLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTV 1779
+L K H + L +VN RW +LL+ IA +++ K L Q+ K +S
Sbjct: 4 RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ---LDKNMSSLR 60
Query: 1780 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 1839
+EL K +E+ + + +L + + + + L E L D
Sbjct: 61 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 1840 ASAASA----IQSDQLSLS---QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 1892
A A A IQ +L +++CA+ +++ ++ ++ F E W+
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAMSM---ERRLKIEETWRLWQKFLDDYSRFEDWL 177
Query: 1893 VEAEEILQGQDPSHSSDLSTI-QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-- 1949
+E PS S + T+ +E +++ + + L+ +N+ RL ++
Sbjct: 178 KSSER--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
Query: 1950 ---EIKRM-QNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 2005
+K+M N+ W + + T +L+ F+ Q + F ++ + +L + + +L
Sbjct: 236 SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT- 294
Query: 2006 EISGNYQHLLE---QQRAHEL--FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 2060
N +H E Q + +L FQ E+ + II G++L+E+ + D +
Sbjct: 295 ----NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
Query: 2061 LTLLSNQWQGVIRRAQQ------RRGIIDSQIRQWQRYREMAEKL---------RKWLVE 2105
L L Q V R ++ R + D + R E+ + R
Sbjct: 351 LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410
Query: 2106 VSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAE 2164
+S P S L S+ PL+ R+ D + + L Y L+ + + + S E
Sbjct: 411 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470
Query: 2165 AALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE-KLRTFKKKLSQS 2223
+ ++ + + + E + L ++ K G +LE ++R K L S
Sbjct: 471 EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530
Query: 2224 LPDHHEELHAEQMRCKELENAVGSWTD-----DLTQLSLLKDTLSAYISADDISILNERV 2278
+ + ++ EN + S T D + +K S D + L ++
Sbjct: 531 -----------RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 579
Query: 2279 ELLQR--------------------QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCE 2318
+ + +WE L Q + ++ + L +W F+ +
Sbjct: 580 KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
Query: 2319 WLTQMESKVSQ------NGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 2372
WL E ++ Q + DI E+ K K+ Q+ + + + + +A
Sbjct: 640 WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD- 698
Query: 2373 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 2432
++ +++ +L ++N RW + L+ L++ L+ Q + L L +I+
Sbjct: 699 SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 758
Query: 2433 AKPIVYDS-CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL-CEVLLH 2479
+ + DS ++E +Q + +++ ++ + VAS+ ++ C++L++
Sbjct: 759 NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 807
Score = 62.0 bits (149), Expect = 9e-09
Identities = 152/818 (18%), Positives = 313/818 (38%), Gaps = 116/818 (14%)
Query: 1287 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
S++E +L ++ + W + ++ + +L+ L + + L WL + L
Sbjct: 15 SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL---A 71
Query: 1347 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATL 1401
+ V E ++ LN E ++++ S+ +SVL+ LL + ++
Sbjct: 72 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
Query: 1402 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 1461
+ +D +W ++ + K+ + S W+ E +
Sbjct: 132 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS- 190
Query: 1462 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 1521
+ Y E L+K++ F+ ++ ++ +N+ +++ R ++TD A L
Sbjct: 191 --GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACSLK 241
Query: 1522 AM----NKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 1577
M N+ W LQ VT ++ L+ + E+E + W + +L
Sbjct: 242 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF-S 300
Query: 1578 QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN 1637
+ VQ +K + + I ++E+I G LI+ + ++I+ L EL +
Sbjct: 301 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
Query: 1638 L-------------------DHMVGQLKILLK--SVLDQWSSHKVAFDKINSYLMEARYS 1676
+ +H + ++ L+ + L H + D + S + S
Sbjct: 361 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
Query: 1677 LSRFRLL---------TGSLEAVQVQVDNLQNLQDDLEK----------------QERSL 1711
LS + L S++++ ++ D+ +L DLE ++ L
Sbjct: 421 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
Query: 1712 QKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 1771
+ +++ ++ E + N +K + + L +I Q KAL D
Sbjct: 481 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR---QLGKAL--------DD 529
Query: 1772 SKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 1831
S+ +QQ E+ K T ++ D +++ + + +VK L E
Sbjct: 530 SR---FQIQQTENIIRS--KTPTGPEL-DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
Query: 1832 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 1891
E L V+ + + + + L A QAL K + ++ + ++ F L ++ AW
Sbjct: 584 ESLPGFVNLHSTETQTAGVIDRWELLQA--QALSK-ELRMKQNLQKWQQFNSDLNSIWAW 640
Query: 1892 IVEAEEIL-QGQDPSHSSDLSTIQERMEEL----------KGQMLKFSSMAPDLDRLNEL 1940
+ + EE L Q Q S+D+ TI+ ++++L K +L + +P+ + +
Sbjct: 641 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
Query: 1941 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF----------LEKCE 1990
R L D R+ +N W + S E LQ L+Q Q F LE +
Sbjct: 701 ESR-DLQD----RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
Query: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEM 2028
+V + L EI ++ L Q + HEL ++++
Sbjct: 756 RRKNEIVPIDSNLDAEILQDHHKQLMQIK-HELLESQL 792
Score = 59.7 bits (143), Expect = 5e-08
Identities = 127/696 (18%), Positives = 276/696 (39%), Gaps = 67/696 (9%)
Query: 2042 GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRK 2101
G+RL + E KL ++++WQ ++ R + + Q+ + LR
Sbjct: 2 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 2102 WLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADS 2161
WL + + ++ + +E Q ++ + + + LL D+
Sbjct: 62 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 2162 GAEAA----LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 2217
A A +Q + +W++ E++ K+ + W+K + + L++ +
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
Query: 2218 KKLSQSLPDHHEELHA-EQMRCKELENAVGSWTDDLTQLSLLKDT---LSAYISADDISI 2273
+ + + P ++ + K+ E + LTQL L+ L+ D
Sbjct: 182 R--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
Query: 2274 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQN 2330
L + V ++W+ L +++ +++ + + F + WLT+M+ + +
Sbjct: 240 LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 299
Query: 2331 GDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 2390
+ ++ I++LK +Q+EI++ Q+ GE+L + S A+ IE +L ++
Sbjct: 300 SECDVQAKIKQLKA-FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 358
Query: 2391 QHLLDLIAARVKKL------------------KETLVAVQQL---DKNMSSLRT--WLAH 2427
Q + + KKL E A+ L D++ SL + ++
Sbjct: 359 QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
Query: 2428 IESELAKPIVYD------SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 2481
+ LA+P+ + + + I + + +L RD+E S ++ + E D
Sbjct: 419 LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE--SAMSRALPSEDEEGQDDK 476
Query: 2482 DACATDAECDS---IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 2538
D A S I ++ + N + +E R K LDD SRF+
Sbjct: 477 DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDD-SRFQ-- 533
Query: 2539 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT-- 2596
++ +E + +G E ++ + + + EC + ++ + + +L E +
Sbjct: 534 IQQTENIIRSKTPTG------PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 587
Query: 2597 --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 2654
+ S + RW+ LQ + S R+K + + ++F + +SI WL + + +
Sbjct: 588 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 647
Query: 2655 LTNIEHFS-ECDVQA---KIKQLKAFQQEISLNHNK 2686
L ++ D+Q +IK+LK Q+ +++H K
Sbjct: 648 LEQLQRLELSTDIQTIELQIKKLKELQK--AVDHRK 681
Score = 58.2 bits (139), Expect = 1e-07
Identities = 139/794 (17%), Positives = 312/794 (39%), Gaps = 85/794 (10%)
Query: 1083 ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVS 1142
+L K+ D + L+ +I +R L + L Q ++ + L L + ++A
Sbjct: 20 KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
Query: 1143 SKEEIQQLLDKHKEYFQGLESH-------MILTETLFRKIISFAVQKE----TQFHTELM 1191
+ EEIQ+ L++ +E + +E H + L E L + A E Q L
Sbjct: 80 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
Query: 1192 AQASAVLKRAHKRGVELEYILETW-SHLD-----EDQQELSRQLEVVESSIPSVGLVEEN 1245
+ + + +R +++E W LD ED + S + SS + V +
Sbjct: 140 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
Query: 1246 EDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTN 1305
E + + H + E K Y+ L R + S L+ +++ + W +
Sbjct: 200 ELKKFEAFQRQVHECLTQLELINKQYRRLARENR---TDSACSLKQMVHEGNQRWDNLQK 256
Query: 1306 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 1365
+++ L RL+ + +++ ++ WL +L ++ E + V+ +
Sbjct: 257 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-----TNIEHFSECD-VQAKIKQ 310
Query: 1366 FLEFSKEVDAQSSLKSSVLSTGNQLL-RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE 1424
F +E+ + +++ G QL+ + + +D A + EL + ++ + +
Sbjct: 311 LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370
Query: 1425 KLHQLQMD-----------KLPSRHAISEVMSWISLMENVIQ-KDEDNIKNSIGYKAIHE 1472
KL +L + +L A+S++ ++++ + N+ S+ E
Sbjct: 371 KLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 430
Query: 1473 YLQKYKGFKIDI------NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKS 1526
+ +D + L+ D + + S+D E + D DF + GA+ S
Sbjct: 431 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ--DDKDFYLR-GAVGLS 487
Query: 1527 WQILQGLVTEKIQLLEGLLES----WSEYENNVQCLKTWFETQEKRLKQQHRI------- 1575
++ ++L E +++ S E+ ++ L + +++Q I
Sbjct: 488 DVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPT 547
Query: 1576 -----GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--GLALIQNKKEDVSSIVMSTL 1628
L +C D +K E ++++ E++ G + + + + ++
Sbjct: 548 GPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI---- 603
Query: 1629 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL--LTGS 1686
W L ++ +K L +W + I ++L + L + + L+
Sbjct: 604 ----DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD 659
Query: 1687 LEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWN- 1745
++ +++Q+ L+ LQ ++ ++ + ++ + + + L + L ++N RW+
Sbjct: 660 IQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGRWDR 718
Query: 1746 --NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD--IADD 1801
+LLEE LQ AL+Q Q + + S ++ + R NE++ +N D I D
Sbjct: 719 VCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775
Query: 1802 EVATWIQDCNDLLK 1815
+Q ++LL+
Sbjct: 776 HHKQLMQIKHELLE 789
Score = 52.4 bits (124), Expect = 7e-06
Identities = 53/268 (19%), Positives = 111/268 (41%), Gaps = 26/268 (9%)
Query: 1508 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 1567
S S ++ +LG +N WQ L L+ +++ L+ L + + + N+ L+TW E
Sbjct: 9 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 68
Query: 1568 RLKQQ--HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKE------- 1618
L + + + +Q L + Q+L ++++EK G+A + N E
Sbjct: 69 ELAKPIVYDSCNSEEIQRKLNEQQEL-------QRDIEK-HSTGVASVLNLCEVLLHDCD 120
Query: 1619 ------DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 1672
+ SI +T R L + W N+ M + ++ ++ W + + +L
Sbjct: 121 ACATDAECDSIQQAT-RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
Query: 1673 ARYSLSRFRLLTGSLEAV-QVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 1731
+ + + F +G + V + ++ + Q + + L+ +L +E
Sbjct: 180 SERT-AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
Query: 1732 TLTNTLKEVNMRWNNLLEEIAEQLQSSK 1759
+L + E N RW+NL + + L+ K
Sbjct: 239 SLKQMVHEGNQRWDNLQKRVTSILRRLK 266
Score = 52.4 bits (124), Expect = 7e-06
Identities = 64/353 (18%), Positives = 156/353 (44%), Gaps = 21/353 (5%)
Query: 1218 LDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 1277
LD+ + ++ + ++ S P+ E + + L SS++ + +++ ++
Sbjct: 527 LDDSRFQIQQTENIIRSKTPTG---PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
Query: 1278 KRLLISISCSDLESQLNQLGECW-LSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 1336
+ L ++ E+Q + + W L +SKEL R++ L+ W ++ S+ + WL
Sbjct: 584 ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL-RMKQNLQKWQQFNSDLNSIWAWLG 642
Query: 1337 SAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 1396
++ LE Q + + +++ + + E K VD + ++ S+ + +
Sbjct: 643 DTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
Query: 1397 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM-ENVIQ 1455
++ L+ LS+++ +W + ++ E+ L D L E+ + LM EN+ +
Sbjct: 701 ESRDLQDRLSQMNGRW----DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
Query: 1456 KDED--NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 1513
+ + I +++ + + ++ ++ K ++ QL V + Q+ V ++ +D
Sbjct: 757 RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL---VNAEGTDC 813
Query: 1514 TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 1566
+ E++ + ++L V+ I+ LE LL + ++ Q L +W E
Sbjct: 814 LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE 862
Score = 52.0 bits (123), Expect = 1e-05
Identities = 177/930 (19%), Positives = 351/930 (37%), Gaps = 131/930 (14%)
Query: 460 KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRS 519
KLG + W+ L ++I+ + + L E L Q+ ++ S+ T + IE SE +P
Sbjct: 20 KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE---SELAKPIVY 76
Query: 520 PESQMAEHQALMDEILMLQDEINELQSSLAE-----ELVSESCE--ADPAEQLALQSTLT 572
E Q ++E LQ +I + + +A E++ C+ A AE ++Q
Sbjct: 77 DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
Query: 573 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDT 632
L R I + +R +EE + Q++ + + WL S++ T
Sbjct: 137 NLDRRWRNICAMSMERRLKIEETW----------RLWQKFLDDYSRFEDWLKSSER---T 183
Query: 633 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 692
A P + + + Q L++L + N+ + + D A L
Sbjct: 184 AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243
Query: 693 LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ--- 749
+ LQ+ + ++ ++EE + T + WL + T
Sbjct: 244 VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE-----TARDSILVWLTEMDLQLTNIEH 298
Query: 750 ----QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE 805
Q+ ++Q K +QE++ + + + ++GE+++ + + + ++ +E
Sbjct: 299 FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--------IIEEE 350
Query: 806 LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKG 865
L D++R + + K L + + E L R L L
Sbjct: 351 L----------DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL--S 398
Query: 866 DVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATST----WLDDV 921
D+ D+SA SLL + SS + Q + E+ D ++ + W D
Sbjct: 399 DLHWHDRSA-DSLLS------PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 451
Query: 922 EERLFVATAL---LPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR-DV 977
+ + +A+ LP E E +++ + +S+ M PE+ + +
Sbjct: 452 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM----------IPESPEAYVKL 501
Query: 978 IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDL--KVLFTSLADNKYIILQKL 1035
E+ + G S L+S + Q + + QI +N + K D Y KL
Sbjct: 502 TENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 561
Query: 1036 ANVFEQPVAEQIEAIQQAEDGLKEFD---AGIIELKRRGDKLQVEQPSMQELSKLQDMYD 1092
+ I+++++ E LKE + G + L + + + + D ++
Sbjct: 562 LG----ECSSSIDSVKRLEHKLKEEEESLPGFVNL----------HSTETQTAGVIDRWE 607
Query: 1093 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 1152
L S+ + QNL Q+ L + L +E++ Q++ +S+ + +L
Sbjct: 608 LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667
Query: 1153 KHKEYFQGLESH---MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE 1209
K + Q H +IL+ L + A KE++ + ++Q + R
Sbjct: 668 KKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS------ 721
Query: 1210 YILETWSHLDEDQ-------QELSR----QLEVVESSIPSVGLVEENEDR--LIDRITLY 1256
+LE W L +D E+S LE ++ + ++ N D L D
Sbjct: 722 -LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
Query: 1257 QHLKSSLNEYQPKLYQVLDDGKRLLIS---ISCSDLESQLNQLGECWLSNTNKMSKELHR 1313
+K L E Q ++ + D +LL++ C + + +++ +G ++S+ +
Sbjct: 781 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
Query: 1314 LETILKHWTRYQSESADLIHWLQSAKDRLE 1343
LE +L S DL W S+ D L+
Sbjct: 841 LEKLLD----VSSSQQDLSSW--SSADELD 864
Score = 40.0 bits (92), Expect = 0.039
Identities = 50/269 (18%), Positives = 111/269 (41%), Gaps = 33/269 (12%)
Query: 2066 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMS-GLGSV 2117
++W+ + +A + + +++WQ++ + WL ++ L +S + ++
Sbjct: 604 DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
Query: 2118 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 2177
+ +++ + L V ++ + IL++ ADS LQ L+++ +
Sbjct: 664 ELQIKKLKELQKAVDHRKAI--------ILSINLCSPEFTQADSKESRDLQDRLSQMNGR 715
Query: 2178 WKSASMRLEEQKKKLAFLL---KDWEKCEKGIADSLEKLRTFKKKL--------SQSLPD 2226
W LEE + L L + + + G+ LE + K ++ ++ L D
Sbjct: 716 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775
Query: 2227 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELL----Q 2282
HH++L + E + V S D QL + + + + + ++ R++LL
Sbjct: 776 HHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVS 835
Query: 2283 RQWEELCHQLSLRRQQIGERLNEWAVFSE 2311
R +EL L + Q + L+ W+ E
Sbjct: 836 RHIKELEKLLDVSSSQ--QDLSSWSSADE 862
Score = 39.3 bits (90), Expect = 0.066
Identities = 45/254 (17%), Positives = 104/254 (40%), Gaps = 12/254 (4%)
Query: 1527 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALK 1586
W++LQ K ++ L+ W ++ +++ + W E+ L+Q R+ +Q
Sbjct: 606 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665
Query: 1587 DCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTLRELGQTWANLDHMVGQ 1644
+ L++L KA + I L + + D S + L ++ W + ++ +
Sbjct: 666 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 725
Query: 1645 LKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR----LLTGSLEA--VQVQVDNLQ 1698
+ LL+ L Q F +++ L+ ++ R + + +L+A +Q L
Sbjct: 726 WRGLLQDALMQCQ----GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
Query: 1699 NLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSS 1758
++ +L + + + ++ QLL + + R LL+E++ ++
Sbjct: 782 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 841
Query: 1759 KALLQLWQRYKDYS 1772
+ LL + +D S
Sbjct: 842 EKLLDVSSSQQDLS 855
Score = 37.0 bits (84), Expect = 0.33
Identities = 62/365 (16%), Positives = 136/365 (37%), Gaps = 17/365 (4%)
Query: 1935 DRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWME 1994
+RL + + ++ E K + +N W + R KL+ L+ Q + +
Sbjct: 3 ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 1995 FLVQTEQKLAVEI---SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV 2051
+L E +LA I S N + + + + Q ++ + S++ + LL
Sbjct: 62 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 2052 ----DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS 2107
+ D L +W+ + + +RR I+ R WQ++ + + WL
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-- 179
Query: 2108 YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE----AGKQLLLSADSGA 2163
+ P T+ E K + F RQ + +E ++L + +
Sbjct: 180 ---SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
Query: 2164 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223
+L+ + E ++W + R+ ++L + E+ E L L +L+
Sbjct: 237 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296
Query: 2224 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 2283
++ A+ + K + + + + Q+ + L D +I+ E ++ L+R
Sbjct: 297 EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
Query: 2284 QWEEL 2288
+E+
Sbjct: 357 YCQEV 361
Score = 33.9 bits (76), Expect = 2.8
Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 8/103 (7%)
Query: 257 MQAAVVQYEQYEQEMKHLQQLIEGAHREIE-DKPVA--TSNIQELQAQISRHEELAQKIK 313
++ +V +Q ++ M L+ + AH E E KP+ + N +E+Q +++ +EL + I+
Sbjct: 42 LKETLVAVQQLDKNMSSLRTWL--AHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 99
Query: 314 GYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD 356
+ +AS+ + C++L T E + + + T +LD
Sbjct: 100 KHSTGVASVLNLCEVL---LHDCDACATDAECDSIQQATRNLD 139
>gi|33624873 spectrin repeat containing, nuclear envelope 2 isoform 4
[Homo sapiens]
Length = 556
Score = 337 bits (863), Expect = 2e-91
Identities = 228/594 (38%), Positives = 315/594 (53%), Gaps = 65/594 (10%)
Query: 2753 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 2812
+ED + W R S +PSS SL ERSG +TP SVDSIPLEWDH
Sbjct: 1 MEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHT 56
Query: 2813 YDLS------RDLESAMSRALPSEDEEGQDDKDFYLR---GAVGLSGDHSALESQIRQLG 2863
D+ D E AL D E ++ + YL+ + S S + +
Sbjct: 57 GDVGGSSSHEEDEEGPYYSAL--SDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVP 114
Query: 2864 KALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKE 2920
+ +Q E R+ P P T YK G + L + + L ++
Sbjct: 115 DSPSCPEHHYKQMEGD-RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQ 173
Query: 2921 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 2980
E+ L G Q +G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL
Sbjct: 174 EDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWL 224
Query: 2981 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 3040
TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S E
Sbjct: 225 KKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPE 284
Query: 3041 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG--------------FHEMSHGL 3086
S +LQ RL Q++ W+ ++ WRG L+ +LMQCQG FH++S L
Sbjct: 285 STELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNL 344
Query: 3087 LLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 3146
LL L + R+ + D D L + ++LMQ++ EL+E Q +V LQ++S LL+
Sbjct: 345 LLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIK 404
Query: 3147 AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSG 3206
G DC+EA+EKVHVI +LK L ++VS + L+ + +Q S S DE+D SG
Sbjct: 405 GHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNPASPLPSFDEVD-SG 457
Query: 3207 SVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLF 3266
P + P R K R R+T+G ++ PG R R FL
Sbjct: 458 DQPPATSVPAP-RAKQFRA---------------VRTTEGEEETESRVPGSTRPQRSFLS 501
Query: 3267 RVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 3320
RV+RAALPLQLLLLLL+ LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 502 RVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 555
Score = 40.0 bits (92), Expect = 0.039
Identities = 59/295 (20%), Positives = 118/295 (40%), Gaps = 20/295 (6%)
Query: 433 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 492
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 157 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 213
Query: 493 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 547
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 214 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 273
Query: 548 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 607
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 274 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 332
Query: 608 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 662
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 333 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 392
Query: 663 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGT 717
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 393 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGT 441
Score = 36.2 bits (82), Expect = 0.56
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 2388 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 2442
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 190 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 242
Query: 2443 SEEIQRKLNEQQELQRDIEKHSTGVASV 2470
+EI+ ++ QE+ + + + V SV
Sbjct: 243 IQEIELRVKRLQEILKAFDTYKALVVSV 270
Score = 32.3 bits (72), Expect = 8.0
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 136 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 195
+ +EL +KI+ QNLQ D+ LKK +A LE + ++ + L+ +
Sbjct: 196 QAQELHNKLKIK-QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR--VKR 252
Query: 196 RQHLLSEMESLKPKVQAVQL 215
Q +L ++ K V +V +
Sbjct: 253 LQEILKAFDTYKALVVSVNV 272
>gi|33624861 spectrin repeat containing, nuclear envelope 2 isoform 2
[Homo sapiens]
Length = 429
Score = 309 bits (791), Expect = 3e-83
Identities = 187/457 (40%), Positives = 260/457 (56%), Gaps = 50/457 (10%)
Query: 2881 RSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 2937
R+ P P T YK G + L + + L ++E+ L G Q
Sbjct: 5 RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------Q 58
Query: 2938 TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELST 2997
+G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL TE ELE L+ + +
Sbjct: 59 QSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS 115
Query: 2998 DIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 3057
DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W+
Sbjct: 116 DIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEA 175
Query: 3058 VCSLLEEWRGLLQDALMQCQG--------------FHEMSHGLLLMLENIDRRKNEIVPI 3103
++ WRG L+ +LMQCQG FH++S LLL L + R+ +
Sbjct: 176 AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 235
Query: 3104 DSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIG 3163
D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI
Sbjct: 236 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIE 295
Query: 3164 NRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTP 3223
+LK L ++VS+ + L+ +Q S S DE+D SG P +
Sbjct: 296 KKLKQLREQVSQDLMALQ------GTQNPASPLPSFDEVD-SGDQPPAT----------- 337
Query: 3224 RGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLI 3283
S P P R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+
Sbjct: 338 ------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLL 391
Query: 3284 GLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 3320
LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 392 LLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 428
Score = 41.2 bits (95), Expect = 0.017
Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 28/340 (8%)
Query: 433 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 492
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 31 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 87
Query: 493 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 547
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 88 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 147
Query: 548 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 607
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 148 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 206
Query: 608 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 662
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 207 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 266
Query: 663 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ--- 719
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 267 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGTQNPAS 320
Query: 720 -----EKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 754
++ +S AT P + RTT ++ S
Sbjct: 321 PLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
Score = 36.2 bits (82), Expect = 0.56
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 2388 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 2442
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 64 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 116
Query: 2443 SEEIQRKLNEQQELQRDIEKHSTGVASV 2470
+EI+ ++ QE+ + + + V SV
Sbjct: 117 IQEIELRVKRLQEILKAFDTYKALVVSV 144
Score = 32.3 bits (72), Expect = 8.0
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 136 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 195
+ +EL +KI+ QNLQ D+ LKK +A LE + ++ + L+ +
Sbjct: 70 QAQELHNKLKIK-QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR--VKR 126
Query: 196 RQHLLSEMESLKPKVQAVQL 215
Q +L ++ K V +V +
Sbjct: 127 LQEILKAFDTYKALVVSVNV 146
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 270 bits (690), Expect = 2e-71
Identities = 613/3315 (18%), Positives = 1281/3315 (38%), Gaps = 365/3315 (11%)
Query: 8 QKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI 67
QK L+ + K+ ++ L + ++ A R + L+ + L + L ++L
Sbjct: 2382 QKVLDMENSFKE--GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSH---LNMLLGQY 2436
Query: 68 EKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQ-----YLTSVYC 122
+ + A AW A + + +L T+ + + +L A T++LQ + V
Sbjct: 2437 HQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL-ATTKQLQEELAEHQVPVEK 2495
Query: 123 TEKMSQQVAELG-------RETEELRQMIKIRLQNL-----------QDAAKDMKKFEAE 164
+K+++ + E+ R +E I Q+L Q A + +
Sbjct: 2496 LQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2555
Query: 165 LKKLQAALEQAQATLTSPEVGRLS---LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALR 221
L+ L ++ + + L +V LS ++E L+ L ++ K ++A + +
Sbjct: 2556 LESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615
Query: 222 IPEDVVASLPLCHAALRLQEEASRLQHTAIQQC---NIMQAAVVQYEQYEQEMKHLQQLI 278
D + L +L E + R + +QQ + ++ + Q E +E LQQ +
Sbjct: 2616 ETADSTTAAVLQG---KLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM 2672
Query: 279 EGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLN------SKC------ 326
E R + +I QI +EL +++ QE + +L S C
Sbjct: 2673 ENKSRMLASGNQPDQDITHFFQQI---QELNLEMEDQQENLDTLEHLVTELSSCGFALDL 2729
Query: 327 -----KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRC---H 378
++ ++ + TV E E A ++ E + T G
Sbjct: 2730 CQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTE 2789
Query: 379 TLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 438
T +S E E S + + + N + +++ ++A Q I
Sbjct: 2790 TSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLI--MEITAPDSQGKTGSI 2847
Query: 439 HPSTSAS----QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
PS +S ++ + D+ +E L V+ E+Q +L L R ++
Sbjct: 2848 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2907
Query: 495 SLQSISTKMEAIELKLSE-----SPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLA 549
S+ +E+ E L SP + ++Q ++A + E+ +I +++ +LA
Sbjct: 2908 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2967
Query: 550 EELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQAL 609
LV+ + +Q L ER + + + QLEE A
Sbjct: 2968 GLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR-----------QLEESASHLAC 3016
Query: 610 QRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSV 669
++ +L WL+ + + +P + AQ Q ML E E + +L+
Sbjct: 3017 --FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
Query: 670 HNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDK-----QLNMQGTAQEKEES 724
+ +L G Q+ +L+ + +EL L+ + Q ++ T ++
Sbjct: 3075 AAQGILT-GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ 3133
Query: 725 DVD---LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQ---ELAEQKSLLRSVASR 778
D+ Q VQ ++ QQ + + + + +LEQ E+ E ++L ++
Sbjct: 3134 DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVL 3193
Query: 779 -GEEIL-------IQHSAAETSGD---AGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 827
GE+ L ++ A G A ++ + L L + D++R +
Sbjct: 3194 IGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQ 3253
Query: 828 QE------FSTKQKLLQNVLEQEQE------------QVLYSRPNRLLSGVPLYKGDVPT 869
+ S K + LQ+ L++ +E +V+ + LL VP P
Sbjct: 3254 SQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVP------PG 3307
Query: 870 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-----IHLEQKLYDGVSATSTWLDDVEER 924
++K + + L L +EE+S ++ A RQS + QK V W++D + +
Sbjct: 3308 EEKRTLQNQLVELKNHWEELSKKT--ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAK 3365
Query: 925 LF-VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLG 983
+ + L P + E+ L + + ++++ ++ + + + D I D
Sbjct: 3366 MSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKA 3425
Query: 984 CLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII-------LQKLA 1036
+ + + + + ++E Q++ FQ K + + K+ + Q +
Sbjct: 3426 GINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS 3485
Query: 1037 NVFEQPVAEQIEAIQQAE---DGLKEFDAGIIELKRRGDK----LQVEQPSMQELSKLQD 1089
N + + Q E +Q E D L+ F G++E G L + + QE +++
Sbjct: 3486 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQ 3545
Query: 1090 MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQ 1149
+ +++ ++ G+ Q + L DL D L+ G + D + S E+++
Sbjct: 3546 RVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD-GMGAIGRDTDSLQSQIEDVRL 3604
Query: 1150 LLDKHKEYFQGLES------HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 1203
L+K +E+ HM+ E + +++E + L Q + +R
Sbjct: 3605 FLNKIHVLKLDIEASEAECRHMLEEEGTLDLL---GLKRELE---ALNKQCGKLTERGKA 3658
Query: 1204 RGVELEYIL---ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 1260
R +LE L E + + + + E E+ VG E ++ + ++Q K
Sbjct: 3659 RQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQ--K 3716
Query: 1261 SSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKELHRLET 1316
++ Q KL QV G+ L+ S LE + ++ W + K+++ + +L+
Sbjct: 3717 EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQE 3776
Query: 1317 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 1376
L H ++Q L+ WL ++ + S E ++V+ + + +D +
Sbjct: 3777 ALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQEQKLLQRLLDDR 3832
Query: 1377 SSLKSSVLSTGNQLLRLKKV-DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 1435
+ + + G ++ + ++ D + +L ++S+WT+LL+ A Q++L + +
Sbjct: 3833 KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQ 3892
Query: 1436 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKIDINCKQLTVDF 1493
+ ++S+ E + E +G + I + + ++K + DI V
Sbjct: 3893 FHETAEPISDFLSVTEKKLANSEP-----VGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947
Query: 1494 ---VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSE 1550
+ QS+ ++S + S+K D ++ + +Q K LL+ L +
Sbjct: 3948 AVKIGQSLSSLTSPAEQGVLSEKID------SLQARYSEIQDRCCRKAALLDQALSNARL 4001
Query: 1551 Y-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG 1609
+ E+ V+ L E ++K + Q + D L + I ++K V++ +NG
Sbjct: 4002 FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNG 4061
Query: 1610 LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSY 1669
AL++ + ++ L + +A++ + L+ + + ++++ +
Sbjct: 4062 QALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 4121
Query: 1670 LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKEC 1725
L E L+ +G Q+ Q Q +L+K+ L ++ LL+
Sbjct: 4122 LREVEEELAT----SGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELV 4177
Query: 1726 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 1785
E L + + N ++ + + I +++ A +Q Q+Y+ Q A
Sbjct: 4178 PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWVAE 4233
Query: 1786 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 1845
T L A + D+ +Q + KDS+ L ++ +
Sbjct: 4234 TKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTV 4293
Query: 1846 IQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 1905
+Q SL Q A+ ++ L+ + F ++ E L WI E ++ Q PS
Sbjct: 4294 LQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALI-AQLPS 4352
Query: 1906 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LNDKE----IKRMQNLNRH 1960
+ D ++++ EE++ + P +D+L ++G +L LN +E ++ Q
Sbjct: 4353 PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENM 4412
Query: 1961 WSLISSQTTERFSKLQSFLLQHQT---FLEKCETWMEFLVQTEQKLAVE--ISGNYQHLL 2015
++ I + +R L + Q F +K E +E L +L + I +
Sbjct: 4413 YAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 4472
Query: 2016 EQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLKLTLLSNQWQGV 2071
E ++ E+ Q ++ G+ L+ + Q D+D E KL + W+ +
Sbjct: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532
Query: 2072 IRRAQQRR----GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ--QAR 2125
RA++R +++ + W + ++ V L G+ I Q A
Sbjct: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592
Query: 2126 TLFDEVQ--FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM 2183
T+ +E +E F+R G+ L+ + + ++ + E+ W++ +
Sbjct: 4593 TIKEETDGLHEELEFIRILGA---------DLIFACGETEKPEVRKSIDEMNNAWENLNK 4643
Query: 2184 RLEEQKKKLAFLLK---DWEKCEKGIADSLEK--------------LRTFKKKLSQSLPD 2226
+E+ +KL ++ ++ + + D L+ L T K +L++ + +
Sbjct: 4644 TWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE-MKE 4702
Query: 2227 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE 2286
E++ +Q+ ++L + +L L K T D I+ E + L+ WE
Sbjct: 4703 FKVEVYQQQIEMEKLNHQ--------GELMLKKAT-----DETDRDIIREPLTELKHLWE 4749
Query: 2287 ELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ----NGDILIEEMIEKL 2342
L +++ R+ ++ L F +EL WLT E + +GD + E +E
Sbjct: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE-VELA 4808
Query: 2343 KKDYQEEIAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 2401
K + +A + ++ + + G L ++S AS + +L +N W+ +L R
Sbjct: 4809 KHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEERE 4868
Query: 2402 KKLKETLVAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRD 2459
++L+ TL Q + L +ES+L+ KP E + +L+ EL
Sbjct: 4869 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT---GGLPETAREQLDTHMELYSQ 4925
Query: 2460 IEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE 2519
++ +L+ ++L D + ++ + Q+ L+++W + + ER+ K+E
Sbjct: 4926 LKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVSSKMEERKSKLE 4982
Query: 2520 ETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ 2579
E L +F + F +WL +E++ S +I ++++ + F +V+ Q
Sbjct: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
Query: 2580 LELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 2639
+ +++ +L ++ +K ++ RW+ + +R R L + ++F
Sbjct: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102
Query: 2640 ARDSILVWLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 2697
A ++ WL + + L + +E ++ D ++ ++ + K FQ+ + + I G L
Sbjct: 5103 AWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL 5162
Query: 2698 IEKS-EPLDAAIIEEELDELRRYCQEVFGR-VERYHKKLIRLPLPDDEHDLSDRELE--- 2752
EK+ P D+ ++ L E+R V G+ VER HK L D ++
Sbjct: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222
Query: 2753 ------LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD--------- 2797
ED DL D+ Q Q L+ RSGR+
Sbjct: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK--RSGRELIENSRDDT 5280
Query: 2798 --TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE---------EGQDDKDFYLRGAV 2846
+ + WD LS +S + +AL + E + + LR
Sbjct: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
Query: 2847 GLSGDHSALESQI---RQLGKALDDSRFQIQQT----ENIIRSKTPTGPELDTSYKGYMK 2899
L D AL+S I ++ K +++ R + E I+ P+ T+ K ++
Sbjct: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL---AVCHPDCITTIKHWIT 5397
Query: 2900 LLGECSSSIDSVKRLEHKL---KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 2956
++ R E L K+ ++ L ET + ++ ELL+ +
Sbjct: 5398 IIR---------ARFEEVLTWAKQHQQRL---------ETALSELVANAELLEELLAWIQ 5439
Query: 2957 LRMKQNLQKWQQ-FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKEL--- 3012
+Q+ Q+ +++ + A + + + +E++ R + D T + K ++
Sbjct: 5440 WAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAP 5499
Query: 3013 ---QKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLL 3069
+ RK++ P +Q+++K R++Q++ RW +V L E + L
Sbjct: 5500 FIEKSRSGGRKSLSQPTPPPMPILSQSEAK-----NPRINQLSARWQQVWLLALERQRKL 5554
Query: 3070 QDALMQCQGFHEMSH 3084
DAL + + E ++
Sbjct: 5555 NDALDRLEELKEFAN 5569
Score = 258 bits (659), Expect = 7e-68
Identities = 641/3361 (19%), Positives = 1348/3361 (40%), Gaps = 376/3361 (11%)
Query: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
EL+ Q + Q ++ L K + K + Q+++ + + S L + +E
Sbjct: 1861 ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWN------SRLLHFQNAVE 1914
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
IEK KVL T LR ++ ++ L+ SK +SE++ + L
Sbjct: 1915 -----IEKTKVLNQHTQLEGRLQDLRA-WVGNKNLILNSKGSNSEIDVDSLNLCLQQYED 1968
Query: 122 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA-KDMKKFEAELKK-LQAALEQAQATL 179
+ M+++ A+L +++ I Q+L + M + EL++ Q LEQ A +
Sbjct: 1969 LKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQV 2028
Query: 180 TSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRL 239
+ + G L EQ + + L + + +++ LC S + E +A H
Sbjct: 2029 DALQ-GHLQQMEQEALVKTLQKQQNTCHQQLE--DLC-SWVGQAERALAG----HQGRTT 2080
Query: 240 QEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQ 299
Q++ S LQ ++ + + +K ++ +E ++ + + T+ ++L
Sbjct: 2081 QQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL-TALREKLH 2139
Query: 300 AQISRHEELAQKIKGYQEQIA-SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGE 358
++E L ++ + Q+++ ++ S + T K+K A + LAE + +D
Sbjct: 2140 QAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAA---------KELAENKKKIDAL 2190
Query: 359 LLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANT-DASVN 417
L S S G+ T L + + SG + + + D
Sbjct: 2191 LDWVTSVGSS-----GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCE 2245
Query: 418 QDIAYYQALSAERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWET 470
A +Q L +++ A T ++Q F + P + KLG+L+ + T
Sbjct: 2246 MMKARHQELLSQQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 2300
Query: 471 LKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEH 527
+ + + + QK+ + + +E E +L + G SPE S +
Sbjct: 2301 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 2360
Query: 528 QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRM 583
+ ++++ + ++ + S + L E+ + E + + L ER + +
Sbjct: 2361 GSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHS 2420
Query: 584 KASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPM 641
K + L LN L + Q ++ AD L +W+ + +A ++ LS +P
Sbjct: 2421 KCTR----LGSHLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPG 2470
Query: 642 DMEAQLMDCQNMLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRR 695
++ QL + + E+ + V + +L V + + +EG+ H ++ + + +
Sbjct: 2471 VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQS 2530
Query: 696 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---Q 752
L SL E + +L K + + QE ES QS G E + + + Q
Sbjct: 2531 LSYSLAE-RSSLLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQ 2584
Query: 753 SSLQQQKELEQELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 809
+L +L+Q++A QKS L R + +R E +AA G E Q +
Sbjct: 2585 EALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQ 2644
Query: 810 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 869
EK S+ ++ + E + + S K LQ +E + L G+ P
Sbjct: 2645 QEKESSLKKLLPQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPD 2686
Query: 870 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 929
QD + + LN E+ +++++ + L +S+ LD + + V
Sbjct: 2687 QDITHFFQQIQELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2738
Query: 930 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 989
L + TE +E KD E++D+ + L + +++T G
Sbjct: 2739 -LRKDFTELQKTVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------ 2783
Query: 990 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEA 1049
S+ + + +++++++ + + +D T + + + E + E
Sbjct: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAP 2838
Query: 1050 IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQN 1108
Q + G G G + +Q ++S + Y++L ++ R+ L
Sbjct: 2839 DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAI 2898
Query: 1109 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH--- 1164
L + + + LE+ +E + + +K E ++ + +K + LE +
Sbjct: 2899 LNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2958
Query: 1165 -MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---D 1219
+ E L ++++ +E + ++ + ++ +RA + V + LE + SHL
Sbjct: 2959 IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQ 3018
Query: 1220 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 1279
+ +L L E + +G + + + L + Q + + + Q+ + +
Sbjct: 3019 AAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQG 3078
Query: 1280 LL-----ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 1334
+L +S+S S ++ +L + + W+ T+K++ +++ + T+YQ DL
Sbjct: 3079 ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK 3138
Query: 1335 LQSAKDRLEFWTQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQL 1390
+++ RL + Q V Q+LE + + + EV +AQ+ + G Q
Sbjct: 3139 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198
Query: 1391 LR---LKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 1447
L+ K+++T L L ++ D + + A Q Q E+ +W+
Sbjct: 3199 LKDELKKRLETVAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWL 3249
Query: 1448 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQ 1504
++ K N S + + LQ+ + F+ +N + + + +S+L +S
Sbjct: 3250 DDKQSQQAK---NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVP 3305
Query: 1505 DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFET 1564
E KR+ QL + W+ L ++ L+ ++ +Y+ +V+ L W E
Sbjct: 3306 PGEEKRT----LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361
Query: 1565 QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI- 1623
+ ++ + D ++++L + + + ++ + +E + LI + + D I
Sbjct: 3362 CKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIR 3421
Query: 1624 ---------VMSTLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINS 1668
+ + EL +L+ M +L+ +S + + + H++ FD + S
Sbjct: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 3481
Query: 1669 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 1728
+ +L + R L+A++ QVD L+N L + GS +QLL +
Sbjct: 3482 QACSNK-NLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVA 3536
Query: 1729 VTETLTNTLKEVNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQ 1774
E L EV R N+ ++E E + Q + +++ + D +
Sbjct: 3537 QQEFL-----EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRD 3591
Query: 1775 CASTVQQQEDRTNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 1833
S Q ED L K K DI E +C +L+ GT+ D L EL
Sbjct: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEAL 3645
Query: 1834 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 1893
KQ + + +QL L+ L +E K + G+ D T A+ EAL+ W+V
Sbjct: 3646 NKQCGKLTERGKARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVV 3697
Query: 1894 EAE-EILQGQDPSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 1951
E EI+ Q +D Q E+++ L+ ++ + + + L + G + E
Sbjct: 3698 GTEVEIINQQ----LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE- 3750
Query: 1952 KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SG 2009
M+ +N W+ ++ + +R ++LQ LL F + E + +L TE+ +A + S
Sbjct: 3751 HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA 3810
Query: 2010 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 2069
Y+ + Q + +L Q + R+ + + +G R+ + ++ DR++ +L L ++W
Sbjct: 3811 EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWT 3870
Query: 2070 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 2129
++ +A R+ ++ + +++ E AE + +L S S P+ Q A+
Sbjct: 3871 ELLSKAAARQKQLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQ 3927
Query: 2130 EVQFK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWK 2179
++ K E+ V+ G Q L S S AE +LQA +EIQ++
Sbjct: 3928 IIRHKALEEDIENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC 3986
Query: 2180 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAE 2234
+ L++ +D + +A+ +KL + FK+ + H L+ E
Sbjct: 3987 RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 4046
Query: 2235 QM-RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
+ R K ++ A+ + +LLK T + +++ ++ E+++ ++ ++ ++ S
Sbjct: 4047 IVNRKKNVDQAIKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSS 4095
Query: 2294 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAI 2352
+ + + F +EL WL ++E +++ +G E I + ++ +E
Sbjct: 4096 KALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKE 4155
Query: 2353 AQENKIQLQQMGERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETL 2408
E+++ L + E +++A E +A E ++ + N++++ + D I RV ++ +
Sbjct: 4156 VMEHRLVLDTVNE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214
Query: 2409 VAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 2466
QQ ++ + W+A + +L PI + ++ +L Q+ DI +H
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDS 4271
Query: 2467 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 2526
+ + + + C + + +Q+ T +L +++ I ++ ER ++E L
Sbjct: 4272 MDELFSHRSEIFGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN 4327
Query: 2527 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 2586
+F + Y W++ + A S + + +++ ++ + + E ++ + K
Sbjct: 4328 QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 4387
Query: 2587 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARD 2642
+L N + +MV E Q+ +N+ ++ +R+ L + Q + D
Sbjct: 4388 GPQLKELNPEEG-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442
Query: 2643 SILVWLTEMD----------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 2692
I L ++ L ++ EC I K+ E+ E +
Sbjct: 4443 KIEPMLETLENLSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKR 4497
Query: 2693 QGEQLIEKSEPLD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 2748
+GE+LI +S+ D A I+++LD++ + +++ R E +
Sbjct: 4498 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------E 4538
Query: 2749 RELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLE 2808
RE++ D L++ W+D +A L + + + ++ L P + + ++I E
Sbjct: 4539 REIKFLDVLELAEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE 4597
Query: 2809 WDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDD 2868
D L +LE G+ +K + ++ L ++ + L+D
Sbjct: 4598 TD---GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4654
Query: 2869 SRFQIQQTENIIRS----------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
+ Q ++ +++ K T P + T L E V+ + ++
Sbjct: 4655 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQI 4712
Query: 2919 KEEEESLPGFVNLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQKWQQF 2969
+ E+ + G + L +T I R WE L + ++ +++ L QF
Sbjct: 4713 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
Query: 2970 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 3029
L + +WL TEE L+ + +S D + IE+++ K L+ V +A + ++N
Sbjct: 4773 QHALEELMSWLTHTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4830
Query: 3030 SPEFTQADS-KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 3088
E ++ + ++ L+ RL MN W+ V EE LQ L Q QGFH LL
Sbjct: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890
Query: 3089 MLENIDRRKNEIVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVASLQDMS 3140
L ++ + + P E L H + Q+K ++LL+ + +D S
Sbjct: 4891 ELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS 4950
Query: 3141 CQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSAD 3200
+ LE +K HV+ ++++ + S+ + L + +S Q+ +W +
Sbjct: 4951 GSGSKTEQSVALLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFINWLTLA 5005
Query: 3201 E 3201
E
Sbjct: 5006 E 5006
Score = 246 bits (629), Expect = 2e-64
Identities = 604/3381 (17%), Positives = 1317/3381 (38%), Gaps = 406/3381 (12%)
Query: 46 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 105
+NQA L++ EM++ + E + +A SA +Q+ H EE + +
Sbjct: 2233 VNQAPEKLDKQCEMMKA--RHQELLSQQQNFILATQSAQAFLDQHG-HNLTPEEQQMLQQ 2289
Query: 106 ELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAEL 165
+L + E QY TS+ +E +QV L E LQ +D K+FE+ L
Sbjct: 2290 KLGELKE--QYSTSLAQSEAELKQVQTLQDE--------------LQKFLQDHKEFESWL 2333
Query: 166 KKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV---QAVQLCQSALRI 222
++ + LE +SPE LK Q S + ++S L+ Q V +++ +
Sbjct: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
Query: 223 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI-MQAAVVQYEQYEQEMKHLQQLIEGA 281
++ L L+ E H+ + + + QY Q++ LQ ++
Sbjct: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 2453
Query: 282 HREIED--KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATML 339
+E S+ LQ Q++ ++L +++ +Q + L +
Sbjct: 2454 EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR------------ 2501
Query: 340 LTVTEVEGLAEGTEDLDGELLPTPSAH-PSVVMMTAGRCHTLLSPVTE-ESGEEGTNSEI 397
+ E+EG E + +H S+ A R L + + +S +E S +
Sbjct: 2502 -DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560
Query: 398 SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEP-- 455
S + +S++ + + +L+ D A+ S A++E +E
Sbjct: 2561 QSIGEVEQ-NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETAD 2619
Query: 456 SATA-----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKL 510
S TA KL ++ + +E L EK+ +L + L + + ++ +S K++
Sbjct: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQFMENK 2675
Query: 511 SESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 570
S G P+ + + E+ + ++ E +L E LV+E A L
Sbjct: 2676 SRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL-EHLVTELSSCGFALDLCQHQ- 2733
Query: 571 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 630
+R+ +R + ++ ++E+ D Q Q L +R WL T+ ++
Sbjct: 2734 -----DRVQNLRKDFTELQKTVKEREKDASSCQEQ---LDEFRKLVRTFQKWLKETEGSI 2785
Query: 631 DTALSPPKEPM----DMEAQLMDCQNMLVEIEQKVVALSELSVHN---ENLLLEGKAHTK 683
PP E ++E Q+ +++L + K + E++ ENL++E T
Sbjct: 2786 -----PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME---ITA 2837
Query: 684 DEAEQLAGKLRRLKGSLLELQRALHD-KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ 742
+++ G + GS + H K L T + + SDV+L + GV
Sbjct: 2838 PDSQGKTGSILPSVGSSVGSVNGYHTCKDL----TEIQCDMSDVNLKYEKLGGV------ 2887
Query: 743 ARTTWTQQRQSSLQQ-QKELEQELAEQKSLLRSVASRGEEILIQHSA------AETSGDA 795
+RQ SLQ +E+ E S+L+ + S+ EE+L A ET
Sbjct: 2888 -----LHERQESLQAILNRMEEVHKEANSVLQWLESK-EEVLKSMDAMSSPTKTETVKAQ 2941
Query: 796 GEKPDVLSQELGMEGEK-------------SSAEDQMRMKWESLHQEFSTKQKLLQNVLE 842
E EL K + Q W+ + +E +++ + V
Sbjct: 2942 AESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTV 3001
Query: 843 QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIH 902
Q Q+ S + + +K + +L L+ + A++Q +
Sbjct: 3002 ARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS-----IDPNMLNAQKQQVQ 3056
Query: 903 LEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKN 962
K ++ L++ + + + T + + + E++++++ +
Sbjct: 3057 FMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSS 3116
Query: 963 LFSQAFPENGDNRDVIEDTLGCL--LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020
QA ++ +++++D + +G+ + S ++ + +K++L++ ++DL+ L
Sbjct: 3117 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQL 3176
Query: 1021 FTSLADNKYIILQKLANVFEQPVAEQI----EAIQQAEDGLKEFDAGIIELKRRGDKLQV 1076
+ + + + + + EQ + +++ E + GL++ A D++
Sbjct: 3177 DHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAA---------DRINR 3227
Query: 1077 EQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE--KMA 1134
Q ++ + Q M+DEL + ++S +N + ++ ER L + E + + +
Sbjct: 3228 LQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHS 3287
Query: 1135 GDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQA 1194
G ++IV+ E + + +E TL +++ E + H E +++
Sbjct: 3288 GSYEVIVAEGESLLLSVPPGEE-----------KRTLQNQLV------ELKNHWEELSKK 3330
Query: 1195 SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRL---ID 1251
+A + S L + Q+ + VE +P + + L +D
Sbjct: 3331 TA----------------DRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLD 3374
Query: 1252 RITLYQHL---KSSLNEYQPK--LYQVLDDGKRLLISISCSD---LESQLNQLGECWLSN 1303
+ L L K+ LNE + + L ++L+ +LI+ S +D + + + + +
Sbjct: 3375 PVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV 3434
Query: 1304 TNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ--QSVTVPQELEMVRD 1361
T ++ + LE + + +Q ++ ++ AK +LE + + LE +R
Sbjct: 3435 TEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA 3494
Query: 1362 HLNAFLEFSKEVDAQSSLKSSVL------STGNQLLRLKKVDTATLRSELSRIDSQWTDL 1415
+VD + ++ S +QLL +V R++S
Sbjct: 3495 QQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNS----- 3549
Query: 1416 LTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV--IQKDEDNIKNSIGYKAIHEY 1473
++ KL + R S++ ++ + I +D D++++ I + + +
Sbjct: 3550 --GCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQI--EDVRLF 3605
Query: 1474 LQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGL 1533
L K K+DI + + + E D +L A+NK L
Sbjct: 3606 LNKIHVLKLDIEASEAECRHMLE----------EEGTLDLLGLKRELEALNKQCGKLTER 3655
Query: 1534 VTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLED 1593
+ + LE L ++ ++ L E+ Q +G + + N Q L D
Sbjct: 3656 GKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIIN-----QQLAD 3710
Query: 1594 LIKAKEKEVEKIEQ-----NGLA--LIQNKKEDVSSIVMS-TLRELGQTWANLDHMVGQL 1645
++++V+ ++ NGL LIQ+ +D + + E+ W L+ V Q
Sbjct: 3711 FKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQR 3770
Query: 1646 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 1705
L+ L + A + + S+L + ++ + + + V+ Q+ + LQ L+
Sbjct: 3771 IAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLD 3830
Query: 1706 KQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLW 1765
++ ++ + ++ + E +T L+ + RW LL + A + + + +L L
Sbjct: 3831 DRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLA 3890
Query: 1766 QRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLF 1825
+++ + ++ + + E + T ++ D+ V ++
Sbjct: 3891 KQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAV- 3949
Query: 1826 FLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSL 1885
++G+ L + + SL ++ C++ L + + F +
Sbjct: 3950 ---KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 4006
Query: 1886 EALEAWIVEAEEILQG-------QDPSHS--SDLSTIQERMEELKGQMLKFSSMAPDLDR 1936
+ W+ E E+ L QD H +D + E + K + + L +
Sbjct: 4007 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLK 4066
Query: 1937 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFL 1996
G + L +++ ++ ++ SS+ + + + Q+ E+ W+
Sbjct: 4067 -QTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLR-- 4123
Query: 1997 VQTEQKLAVEISGNYQHLLEQ-----QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV 2051
+ E++LA SG EQ QR EL + E+ + +L ++ + LLE
Sbjct: 4124 -EVEEELAT--SGGQSPTGEQIPQFQQRQKEL-KKEVMEHRLVLDTVNEVSRALLELVPW 4179
Query: 2052 DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPM 2111
R+ + ++ + Q++ V QR ID+ I++ Q+Y + A+ W+ E M
Sbjct: 4180 RAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLM 4239
Query: 2112 SGLGSVPIPLQQARTLFD-EVQFKEKV-FLRQQGSYILTVEAGKQLLLSADSGAEAALQA 2169
+ LG PI L+Q +T +VQ + +R + S ++ + + LQ
Sbjct: 4240 A-LG--PIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQE 4296
Query: 2170 ELAEIQEKWKSASMRLEEQKKKL----AFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 2225
+ + +++++ S+ E+ +L + + WE E+ ++ +E+ R +L
Sbjct: 4297 KTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE-LSPWIEETRALIAQLPSPAI 4355
Query: 2226 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQW 2285
DH E+L +Q ++L ++ + +L + L ++ ++ ++ E+ + + +
Sbjct: 4356 DH-EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE-LNPEEGEMVEEKYQKAENMY 4413
Query: 2286 EELCHQLSLRRQQIGERLNEWAV---FSEKNKELCEWLTQMESKVSQNGDILIEEMIEKL 2342
++ ++ R + E +++ F +K + + E L + S++ LI ++K+
Sbjct: 4414 AQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP--LIPAEVDKI 4471
Query: 2343 KKDYQE-EIAIAQENKIQ-----LQQMGERLAKASH----ESKASEIEYKLGKVNDRWQH 2392
++ + + A + K+Q L++ GE L S + A EI+ KL ++ W+
Sbjct: 4472 RECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED 4531
Query: 2393 LLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNE 2452
+ R K + L ++ +M++L T + + IV+D + + +
Sbjct: 4532 IKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQD-----IVHDLESPGIDPSIIKQ 4586
Query: 2453 QQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSM 2512
Q E I++ + G+ L +L D + E ++++ ++ W N+
Sbjct: 4587 QVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWK 4646
Query: 2513 ERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQ 2572
ER K+E+ + ++ D DWL ++ G K++L + + F+ +
Sbjct: 4647 ERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVE 4706
Query: 2573 VHECLTQLELINKQYRRLARE--NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHF 2630
V++ ++E +N Q + ++ + TD +++ + E W+NL +++ +L+
Sbjct: 4707 VYQQQIEMEKLNHQGELMLKKATDETDRDI-IREPLTELKHLWENLGEKIAHRQHKLEGA 4765
Query: 2631 IGQREEFETARDSILVWLTEMDLQLTNIEHFSECD---VQAKIKQLKAFQQEISLNHNKI 2687
+ +F+ A + ++ WLT + +L + + D ++ ++ + + ++ + +
Sbjct: 4766 LLALGQFQHALEELMSWLTHTE-ELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATV 4824
Query: 2688 EQIIAQGEQLIEKSEPLDAAIIE--------------EELDELRRYCQEVFGRVERYHKK 2733
E + G +L+E S DA+ + ++ +E + Q + + +H +
Sbjct: 4825 ETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSE 4884
Query: 2734 ----LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 2789
L+ L + + S L ++A L H L + + + N L + +
Sbjct: 4885 IEDFLLELTRMESQLSASKPTGGLPETAR-EQLDTHMELYSQLKAKEETYNQLLDKGRLM 4943
Query: 2790 RSER----SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY---- 2841
R SG T SV + +W + +S + AL E ++F
Sbjct: 4944 LLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLT 5003
Query: 2842 ---------------LRGAVGLSGDH-------SALESQIRQLGKALDDSRFQIQQT--- 2876
L + +H +A QI +L + + +F Q+
Sbjct: 5004 LAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVV 5063
Query: 2877 -------------ENIIRSKTPTGPELDTSYK-------GYMKLLG-------------E 2903
E +++ G LD + K + KL+ E
Sbjct: 5064 LIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 5123
Query: 2904 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI--------------------- 2942
S+ D +K K KE +++L G ++ T +T +
Sbjct: 5124 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVR 5183
Query: 2943 DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 3002
D+W+ + +++ ++ ++++ L QF L ++ WL E +L + Q + D+
Sbjct: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMN 5243
Query: 3003 ELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLL 3062
+ K+ QK + R + + E + ++ ++ +L +++ RWD VC L
Sbjct: 5244 LMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLS 5301
Query: 3063 EEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLM 3120
+ L+ AL Q + F + H LL L ++ R +P D+ + L D HK+ M
Sbjct: 5302 VSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA-LQSLIDTHKEFM 5360
Query: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLLLKEVSRHIKE 3179
+ ++ E ++ V S M ++++ DC+ K + +I R + +L +H +
Sbjct: 5361 K---KVEEKRVDVNSAVAMG-EVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQR 5416
Query: 3180 LEKLLD--VSSSQ--QDLSSW 3196
LE L V++++ ++L +W
Sbjct: 5417 LETALSELVANAELLEELLAW 5437
Score = 209 bits (533), Expect = 3e-53
Identities = 571/3042 (18%), Positives = 1168/3042 (38%), Gaps = 431/3042 (14%)
Query: 406 PSPVANTDAS----VNQDIAYYQALSAERLQTDAAKIHPSTSASQEFY-EPGLEPSATAK 460
PS ++ TD S Q+ Y + + + +I S ++ Y E +P+ K
Sbjct: 1566 PSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLK 1625
Query: 461 LGDLQRSWETLKNV----ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 516
L ++ S K V S+++ ++ + K +L+S E K E P
Sbjct: 1626 LEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANP 1685
Query: 517 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQ---------LAL 567
+A +A E ++ Q L S L E+L + + Q L
Sbjct: 1686 N------VAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLET 1739
Query: 568 QSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL----------------EEQRQEQ-ALQ 610
TV S ++ + + + +L E ++Q E R Q
Sbjct: 1740 SEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFT 1799
Query: 611 RYRC-EADE-LDSWL-LSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK---VVAL 664
R C E DE L S+L L + T P E E Q + CQ ++E E K +
Sbjct: 1800 RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVS 1859
Query: 665 SELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEES 724
EL N+ ++ + + + L + L+ SL + + + L+ Q A E E++
Sbjct: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQN-AVEIEKT 1918
Query: 725 DVDLTATQSPG----VQEWLAQARTTWTQQRQSS----------LQQQKELEQELAEQKS 770
V TQ G ++ W+ + +S LQQ ++L+Q +AE+K+
Sbjct: 1919 KVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKA 1978
Query: 771 LLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEG----EKSSAE-DQMRMKWES 825
L ++A + + +H A + S + L EL E+++A+ D ++ +
Sbjct: 1979 QLDALAFDIQFFISEH-AQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQ 2037
Query: 826 LHQEFSTKQ-KLLQNVLEQEQEQVL--YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGL 882
+ QE K + QN Q+ E + + R L+G ++G QD SA+ L
Sbjct: 2038 MEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAG---HQGRTTQQDLSALQKNQSDL 2094
Query: 883 NQAFEEVSSQSGG-------------------------AKRQSIHLEQKLYDGV-SATST 916
+++ +++ A R+ +H ++ Y+ + T
Sbjct: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRV 2154
Query: 917 WLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD--- 973
++EE T+ L +ETE + AK++ E +++D + + G
Sbjct: 2155 AQKELEE---AVTSALQQETE-----KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLT 2206
Query: 974 NRDVIEDTLGCLL--GRLSLLDSV--VNQ-------RCHQMKERLQQILNFQNDLKVLFT 1022
N +E G L G L D VNQ +C MK R Q++L+ Q + +
Sbjct: 2207 NLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQ 2266
Query: 1023 S----LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ 1078
S L + + + + + +Q + E E Q L + +A + +++ D+L Q
Sbjct: 2267 SAQAFLDQHGHNLTPEEQQMLQQKLGELKE---QYSTSLAQSEAELKQVQTLQDEL---Q 2320
Query: 1079 PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 1138
+Q+ + + + + + G + TL S +R D++ GD +
Sbjct: 2321 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI-----SHKGDLR 2375
Query: 1139 IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVL 1198
+ S Q++LD + +G E I L + + A ++ T H+
Sbjct: 2376 FVTISG---QKVLDMENSFKEGKEPSEI--GNLVKDKLKDATERYTALHS---------- 2420
Query: 1199 KRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV--GLVEENEDRLIDRITLY 1256
+ + G L +L + L ++ E+++ + V + L +++
Sbjct: 2421 -KCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATT 2479
Query: 1257 QHLKSSLNEYQ---PKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHR 1313
+ L+ L E+Q KL +V D + I + + + + LS+ +S L
Sbjct: 2480 KQLQEELAEHQVPVEKLQKVARD--IMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE 2537
Query: 1314 LETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE----------MVRDHL 1363
++L+ I QS ++ LE Q V Q LE ++++ L
Sbjct: 2538 RSSLLQ----------KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEAL 2587
Query: 1364 NAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQ 1423
++ +++ Q KSS+ +T + R + +T + L + V
Sbjct: 2588 ATNMKLKQDIARQ---KSSLEATREMVTRFMETADSTTAAVLQ----------GKLAEVS 2634
Query: 1424 EKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--------IHEYLQ 1475
++ QL + + ++ +++ + E++ K + ++N A I + Q
Sbjct: 2635 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQ 2694
Query: 1476 KYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVT 1535
+ + +++ +Q +D + V ++SS D +++ + K + LQ V
Sbjct: 2695 QIQELNLEMEDQQENLDTLEHLVTELSSCGF---ALDLCQHQDRVQNLRKDFTELQKTVK 2751
Query: 1536 EKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLI 1595
E+ + E E+ V+ + W + E + ++ ++ + L D
Sbjct: 2752 EREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW 2811
Query: 1596 KAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQ 1655
+K VE+I G +L +++M Q G+ +L SV
Sbjct: 2812 ASKGTLVEEINCKGTSL--------ENLIMEITAPDSQ---------GKTGSILPSVGSS 2854
Query: 1656 WSSHKVAFDKINSY-----LMEARYSLS----RFRLLTGSLEAVQVQVDNLQNLQDDLEK 1706
S +N Y L E + +S ++ L G L Q + + N +++ K
Sbjct: 2855 VGS-------VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2907
Query: 1707 QERSLQKFGSITNQLLKECHPPVTETLTNTLK---EVNMRWNNLLEEIAEQLQSSK-ALL 1762
+ S+ ++ ++LK + T T T+K E N + LE+ + ++Q K AL
Sbjct: 2908 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2967
Query: 1763 QLWQRYKDYS-----KQCASTVQQQEDRTNELLKAATNK-----------DIADDEVATW 1806
L Y + K+ + + +R E+ A + A+ ++ W
Sbjct: 2968 GLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW 3027
Query: 1807 IQDCNDLLKG-----------LGTVKDSLFFLHELGEQLKQQVD---------------- 1839
+ + +L+ G L K + F+ + E +QQ +
Sbjct: 3028 LME-KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 3086
Query: 1840 ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL 1899
+ + S +Q + S++Q L L + + + ++ + + L+ L + + L
Sbjct: 3087 SLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL 3146
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRL-----------NELGYRLP--- 1945
Q S I + E +K Q+ + S + DL++L +EL +
Sbjct: 3147 SVQ--------SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198
Query: 1946 LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL---QHQTFLEKCETWMEFLVQTEQK 2002
L D+ KR++ + + +R ++LQ+ L Q Q ++ TW++ Q++Q
Sbjct: 3199 LKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD-KQSQQA 3257
Query: 2003 LAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQR-LLEQGQVDDRDEFNLKL 2061
IS + L Q + +E FQ + I+ +G+ LL +++ +L
Sbjct: 3258 KNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQL 3317
Query: 2062 TLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPL 2121
L N W+ + ++ R+ + +++ Q+Y+ E L W +E MS L P+
Sbjct: 3318 VELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPW-IEDCKAKMSELRVTLDPV 3376
Query: 2122 QQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQ------ 2175
Q +L +V R+ S + + + +L+++ E ++ E A I
Sbjct: 3377 QLESSLLRSKAMLNEVEKRR--SLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV 3434
Query: 2176 -EKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH-EELHA 2233
E+ ++ + LEE ++L + ++ EK + + +L F SQ+ + + E+L A
Sbjct: 3435 TEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA 3494
Query: 2234 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
+Q + LE V + + TQ L++D D S L + E+ Q+++ E+ +++
Sbjct: 3495 QQEVLQALEPQV-DYLRNFTQ-GLVEDA----PDGSDASQLLHQAEVAQQEFLEVKQRVN 3548
Query: 2294 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI---------------LIEEM 2338
+ +L F + +E+ L ++ ++ G I L
Sbjct: 3549 SGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNK 3608
Query: 2339 IEKLKKDYQEEIA-----IAQEN-------KIQLQQMGERLAKASHESKA--SEIEYKLG 2384
I LK D + A + +E K +L+ + ++ K + KA ++E LG
Sbjct: 3609 IHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLG 3668
Query: 2385 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 2444
+V D ++ ++K L + A ++ + + T + I +LA ++ +
Sbjct: 3669 RVEDFYR--------KLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720
Query: 2445 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 2504
+Q KL + L + + + D + ++ ++ RW
Sbjct: 3721 PLQMKLQQVNGLGQGL--------------------IQSAGKDCDVQGLEHDMEEINARW 3760
Query: 2505 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK 2564
+ +R +++E KF D WL +E A Y V K +++
Sbjct: 3761 NTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
Query: 2565 KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL 2624
+ + QR + + ++++ + R+A+ + + RW L + +
Sbjct: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
Query: 2625 RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SECDVQAKIKQLKAFQQEISL 2682
++L+ + ++F + I +L+ + +L N E +Q +I + KA +++I
Sbjct: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
Query: 2683 NHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL------IR 2736
+ + Q + G+ L + P + ++ E++D L+ E+ R R L R
Sbjct: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 4000
Query: 2737 LPLPDDEHDLSDRELELED---SAALSDLH---WHDRSADSLLSPQPSSNLSLSLAQPLR 2790
L +DE ++ + E+ED S + D H + AD L + N ++ Q ++
Sbjct: 4001 L-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 4059
Query: 2791 SERS--GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 2848
+ ++ + T V I + D D+ S+AL + ++ Q A
Sbjct: 4060 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ--------LATKF 4111
Query: 2849 SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSI 2908
+ L +R++ + L S Q E I P+ K K + E +
Sbjct: 4112 QSTYEELTGWLREVEEELATSGGQSPTGEQI--------PQFQQRQKELKKEVMEHRLVL 4163
Query: 2909 DSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ 2968
D+V + L E L + + + ++++L+ + + +Q+ QQ
Sbjct: 4164 DTVNEVSRALLE----LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
Query: 2969 FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINL 3028
+ ++ AW+ +T+ +L L + L D T +LQ++K + + H+ ++ +
Sbjct: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID-IIRHKDSMDELFSH 4278
Query: 3029 CSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 3088
S F ++ LQ++ + +++ + L E L+ A + F E L
Sbjct: 4279 RSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 4338
Query: 3089 MLENIDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VN 3146
+E + I + S +D E L+ +++ Q++ + E + + L + QL +N
Sbjct: 4339 WIE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN 4395
Query: 3147 AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 3188
E + +E EK N + +EV + L++ + S+
Sbjct: 4396 PEEGEMVE--EKYQKAENMYAQIKEEVRQRALALDEAVSQST 4435
Score = 187 bits (475), Expect = 1e-46
Identities = 548/3186 (17%), Positives = 1207/3186 (37%), Gaps = 458/3186 (14%)
Query: 257 MQAAVVQYEQYEQEMKHLQQLIEGAHREIED-KPVATSNIQELQAQISRHEELAQKIKGY 315
+Q + Q + E+E+K L L+ +E+E + S QE+ AQ+ + L + K
Sbjct: 1837 LQDLLCQAKVLERELKDLTTLVS---QELECVNQIIISQPQEVPAQLLK--ALEKDAKNL 1891
Query: 316 QEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG 375
Q+ ++S++ + ++A + + + + L + T+ L+G L + G
Sbjct: 1892 QKSLSSVSDTWNSRLLHFQNA---VEIEKTKVLNQHTQ-LEGRLQD--------LRAWVG 1939
Query: 376 RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDA 435
+ +L+ +G+NSEI V + + + Q Q ++ + Q DA
Sbjct: 1940 NKNLILN-------SKGSNSEID----------VDSLNLCLQQYEDLKQPMAERKAQLDA 1982
Query: 436 AKIHPSTSASQEFYE--PGLEPSATAKLGDLQRSWETLKNVISEK------------QRT 481
S+ + P L +LQRS++ + + + Q
Sbjct: 1983 LAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA 2042
Query: 482 LYEALERQQKY-QDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 540
L + L++QQ L+ + + + E L+ GR+ + ++ Q ++ LQD+
Sbjct: 2043 LVKTLQKQQNTCHQQLEDLCSWVGQAERALAG--HQGRTTQQDLSALQKNQSDLKDLQDD 2100
Query: 541 INELQSSLA------EELVSES-CEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE 593
I +S A E + E+ + P E AL+ L E+ ++ + ++ LE
Sbjct: 2101 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 2160
Query: 594 EKLNDQLEEQRQE----QALQRYRCEADELDSWLLST----------------------- 626
E + L+++ ++ + L + + D L W+ S
Sbjct: 2161 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE 2220
Query: 627 KATLDTA-----LSPPKEPMDMEAQLMDCQNM-LVEIEQKVVALSE-----LSVHNENLL 675
K LDT ++ E +D + ++M ++ L+ +Q + ++ L H NL
Sbjct: 2221 KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNL- 2279
Query: 676 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPG 735
T +E + L KL LK A + +L T Q++ + +
Sbjct: 2280 ------TPEEQQMLQQKLGELKEQY-STSLAQSEAELKQVQTLQDELQKFLQ----DHKE 2328
Query: 736 VQEWLAQARTTWTQQRQ---------SSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 786
+ WL ++ + S L++Q +++ K LR V G+++L
Sbjct: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
Query: 787 SAAETSGDAGEKPDVLSQELGMEGEKSSA--------EDQMRMKWESLHQEFSTK----- 833
++ + + E +++ +L E+ +A + M HQ ++
Sbjct: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448
Query: 834 ---------QKLLQNVL-------------------EQEQEQVLYSRPNRLLSGVPLYKG 865
+KLL + + E + QV + ++ + +G
Sbjct: 2449 WMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEG 2508
Query: 866 DVPTQDKSAVTSLLDGLNQAFEEVS---SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVE 922
+ P D V D + F+ +S ++ +++I Q + + + + + +VE
Sbjct: 2509 E-PAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2567
Query: 923 ERLF--VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIED 980
+ L ++L + L L +DI ++ + + ++ F E D+
Sbjct: 2568 QNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTR-FMETADST----- 2621
Query: 981 TLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFE 1040
T L G+L+ + Q C Q +E+ ++ LK L ++ L F
Sbjct: 2622 TAAVLQGKLAEVSQRFEQLCLQQQEK-------ESSLKKLLPQAEMFEH--LSGKLQQFM 2672
Query: 1041 QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGS 1100
+ + + + Q + + F I EL L++E + L L+ + EL
Sbjct: 2673 ENKSRMLASGNQPDQDITHFFQQIQELN-----LEMED-QQENLDTLEHLVTEL------ 2720
Query: 1101 RRSGLNQNLTLKSQYERAL---QDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY 1157
S L L +R +D +L +T +E+ D +E ++L+ +++
Sbjct: 2721 --SSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK-DASSCQEQLDEFRKLVRTFQKW 2777
Query: 1158 FQGLESHMILTETLFRKIISFAVQKETQFHTELM---AQASAVLKRAHKRGVELEYILET 1214
+ E + TET + + ++K+ + L+ A +++ + +G LE ++
Sbjct: 2778 LKETEGSIPPTET---SMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME 2834
Query: 1215 WSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVL 1274
+ D + S +PSVG + + Y H L E Q +
Sbjct: 2835 ITAPDSQGK--------TGSILPSVG-------SSVGSVNGY-HTCKDLTEIQCDM---- 2874
Query: 1275 DDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 1334
SD+ + +LG + L+R+E + K E+ ++ W
Sbjct: 2875 ------------SDVNLKYEKLGGVLHERQESLQAILNRMEEVHK-------EANSVLQW 2915
Query: 1335 LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL- 1393
L+S ++ L+ + +++ P + E V+ + F E++ S V LL
Sbjct: 2916 LESKEEVLK--SMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTY 2973
Query: 1394 -KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMEN 1452
+ + ++S+W A Q +L + + A S++ W+
Sbjct: 2974 PNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM---- 3029
Query: 1453 VIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD 1512
+++ + +G +I + + ++ K+ L ++Q + + D
Sbjct: 3030 ----EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGD 3085
Query: 1513 ----KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 1568
+ ++L ++N+ W L + + ++ + ++Y+ +Q L +R
Sbjct: 3086 VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQR 3145
Query: 1569 LKQQHRIGDQA-SVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSIVM 1625
L Q I Q +V+ L++ ++ ++ + EV++ + + L+++ ++ + +
Sbjct: 3146 LSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY-LKDELK 3204
Query: 1626 STLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTG 1685
L + L+ + L++ L + FD++ ++L + + ++ ++
Sbjct: 3205 KRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA 3264
Query: 1686 SLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE--TLTNTLKEVNMR 1743
LE +Q Q+ + Q L + S + + LL PP E TL N L E+
Sbjct: 3265 KLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV-PPGEEKRTLQNQLVELKNH 3323
Query: 1744 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADD-- 1801
W L ++ A++ K +Q Q+Y+ + + ++ + + +EL +
Sbjct: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383
Query: 1802 ---EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLC 1858
+ ++ LL+ L + D L E E I+ ++ ++Q++
Sbjct: 3384 RSKAMLNEVEKRRSLLEILNSAADILINSSEADED-----------GIRDEKAGINQNMD 3432
Query: 1859 ALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERME 1918
A+ + L + SL+ F +S + +E + A+ L+ D S S + +E
Sbjct: 3433 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSN--KNLE 3490
Query: 1919 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSF 1978
+L+ Q ++ P +D L +N + + ++ L
Sbjct: 3491 KLRAQQEVLQALEPQVDYL-----------------RNFTQGLVEDAPDGSDASQLLHQA 3533
Query: 1979 LLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQ--AEMFSRQQILH 2036
+ Q FLE + V E KL E G + R E+F A++ +
Sbjct: 3534 EVAQQEFLEVKQRVNSGCVMMENKL--EGIGQFHC-----RVREMFSQLADLDDELDGMG 3586
Query: 2037 SIIIDGQRLLEQGQVDDRDEFNLKLTLLS---NQWQGVIRRAQQRRGIID---------- 2083
+I D L Q Q++D F K+ +L + R + G +D
Sbjct: 3587 AIGRDTDSL--QSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEA 3644
Query: 2084 -----SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVF 2138
++ + + R+ +L VE Y + GL ++A L V + ++
Sbjct: 3645 LNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEII 3704
Query: 2139 LRQQGSYILTVEA---------------GKQLLLSADSGAEA-ALQAELAEIQEKWKSAS 2182
+Q + + + G+ L+ SA + L+ ++ EI +W + +
Sbjct: 3705 NQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764
Query: 2183 MRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD--HHEELHAEQMRCKE 2240
++ ++ +L L K + + L L ++ ++ P ++ + A+ K
Sbjct: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824
Query: 2241 LENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 2300
L+ + + L ++ D + ++E L+ +W EL + + R++Q+
Sbjct: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884
Query: 2301 ERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQE 2355
+ L F E + + ++L+ E K++ + + I++ I + K +E+I
Sbjct: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR-HKALEEDIENHAT 3943
Query: 2356 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 2415
+ Q ++G+ L+ + ++ + K+ + R+ + D + L + L +
Sbjct: 3944 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFG 4003
Query: 2416 KNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE 2475
++ + WLA +E +L+ V D + + R+ + L +I V + +
Sbjct: 4004 EDEVEVLNWLAEVEDKLSSVFVKDF-KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 4062
Query: 2476 VLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRF 2535
LL T E IQ+ + R+ +I S + +E+ +L KF Y
Sbjct: 4063 ALLKQ----TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEEL 4118
Query: 2536 EDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENR 2595
WL+ E A + ++ + +++V E L+ +N+ R L
Sbjct: 4119 TGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178
Query: 2596 TDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL 2655
+ L ++V + N+++ + + + + I + +++E A D+ L W+ E +L
Sbjct: 4179 WRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 4238
Query: 2656 TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 2715
++L ++EQ + ++K+ +D ++ +DE
Sbjct: 4239 ------------------------MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
Query: 2716 LRRYCQEVFGRVERYHKKLIRLPLPD--DEHDL-----SDRELELEDSAALSDLHWHDRS 2768
L + E+FG K +++ +++ S+R LE + L + W
Sbjct: 4275 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 4334
Query: 2769 ADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALP 2828
LSP +L P +PA +D L + R L +++ P
Sbjct: 4335 E---LSPWIEETRALIAQLP---------SPA-IDHEQLRQQQEE--MRQLRESIAEHKP 4379
Query: 2829 SED--------------EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQ 2874
D EEG+ ++ Y + ++ ++ ++RQ ALD++ Q
Sbjct: 4380 HIDKLLKIGPQLKELNPEEGEMVEEKYQKA----ENMYAQIKEEVRQRALALDEAVSQST 4435
Query: 2875 Q-------------TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE---HKL 2918
Q T + S+ P + + + + S+ +++L+ L
Sbjct: 4436 QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEAL 4495
Query: 2919 KEEEESLPGFVNLHSTETQTAGVIDR-------WELLQAQALSKELRMKQNLQKWQQFNS 2971
K E L G + + D+ WE ++A+A +E++ L+ ++F
Sbjct: 4496 KRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWY 4555
Query: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
D+ ++ + DT++ + L+ + I I+ Q++ + +++ D + I +
Sbjct: 4556 DMAALLTTIKDTQDIVHDLESPGIDPSI--IKQQVEAAETIKEETDGLHEELEFIRILGA 4613
Query: 3032 EFTQA-DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 3090
+ A E +++ + +MN W+ + +E L+DA+ + + + L
Sbjct: 4614 DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4673
Query: 3091 ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA-EG 3149
+N + + P+ ++L+ ++D ++ + K E+ + Q+ + L +L A +
Sbjct: 4674 DNTVIKLCTMPPVGTDLNT--VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDE 4731
Query: 3150 TDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE--LD 3203
TD +E + + + + L ++++ +LE L + ++L SW + E LD
Sbjct: 4732 TDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLD 4791
Query: 3204 TSGSVS 3209
+S
Sbjct: 4792 AQRPIS 4797
Score = 117 bits (292), Expect = 2e-25
Identities = 325/1902 (17%), Positives = 768/1902 (40%), Gaps = 237/1902 (12%)
Query: 1442 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT------VDFVN 1495
+++S++SL+ N+ + + + + + L + K + ++ K LT ++ VN
Sbjct: 1809 KLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLEREL--KDLTTLVSQELECVN 1866
Query: 1496 QSVL----QISSQDVESKRSDKTDFAEQLGAMNKSW--QILQGLVTEKIQLLEGLLESWS 1549
Q ++ ++ +Q +++ D + + L +++ +W ++L +I+ + +L +
Sbjct: 1867 QIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK-VLNQHT 1925
Query: 1550 EYENNVQCLKTWFETQEKRL--KQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 1607
+ E +Q L+ W + L K + D S+ L+ +DL+ + ++ +++ +
Sbjct: 1926 QLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAF 1985
Query: 1608 NGLALIQNKKEDVSSI----VMSTLRELG--------QTWANLDHMVGQLK-----ILLK 1650
+ I +D+S ++ L EL QT A +D + G L+ L+K
Sbjct: 1986 DIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVK 2045
Query: 1651 SVLDQWSSHKVAFDKINSYLMEARYSLS--RFRLLTGSLEAVQVQVDNLQNLQDDLEKQE 1708
++ Q ++ + + S++ +A +L+ + R L A+Q +L++LQDD++ +
Sbjct: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRA 2105
Query: 1709 RSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY 1768
S ++E ++ L+E L + EQ ++ + ++ Q
Sbjct: 2106 TSFATVVKDIEGFMEENQTKLSPRELTALREK-------LHQAKEQYEALQEETRVAQ-- 2156
Query: 1769 KDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLH 1828
K+ + S +QQ+ +++ + A NK D + D + +G+ L
Sbjct: 2157 KELEEAVTSALQQETEKSKAAKELAENKKKIDALL--------DWVTSVGSSGGQLLTNL 2208
Query: 1829 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEAL 1888
EQL A + ++Q L++ + Q + + F + ++
Sbjct: 2209 PGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSA 2268
Query: 1889 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLND 1948
+A++ + L ++ +Q+++ ELK Q L ++
Sbjct: 2269 QAFLDQHGHNLTPEEQQ------MLQQKLGELKEQY----------------STSLAQSE 2306
Query: 1949 KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEIS 2008
E+K++Q L +LQ FL H+ F E+W+E ++E++L
Sbjct: 2307 AELKQVQTLQ--------------DELQKFLQDHKEF----ESWLE---RSEKELENMHK 2345
Query: 2009 GNYQ-----HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-----DDRDEFN 2058
G LL++Q + F ++ S + L + I GQ++L+ + + N
Sbjct: 2346 GGSSPETLPSLLKRQGS---FSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 2402
Query: 2059 L---KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL----VEVSYLPM 2111
L KL + ++ + + + ++ + Q+ +++ A+ L+ W+ V L
Sbjct: 2403 LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLS 2462
Query: 2112 SGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA-LQAE 2170
+ S P LQ+ L Q +E++ Q L A + + + + +Q
Sbjct: 2463 DTVASDPGVLQEQ--LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET 2520
Query: 2171 LAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK-----KKLSQSLP 2225
I ++S S L E+ L + + ++ + L+ + + K++S
Sbjct: 2521 TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2580
Query: 2226 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD---ISILNERVELLQ 2282
+E A M+ K+ + L ++ ++ ++ D ++L ++ +
Sbjct: 2581 GVIQEALATNMKLKQ------DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVS 2634
Query: 2283 RQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKL 2342
+++E+LC Q + + + L + +F + +L +++ + +S++ +G+ +++
Sbjct: 2635 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM-ENKSRMLASGNQPDQDITHFF 2693
Query: 2343 KK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 2400
++ + E+ QEN L+ + L+ + + ++ + + L + R
Sbjct: 2694 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKER 2753
Query: 2401 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRD- 2459
K + + K + + + WL E + P S +++E+++++ + L D
Sbjct: 2754 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSI--PPTETSMSAKELEKQIEHLKSLLDDW 2811
Query: 2460 ------IEKHSTGVASVLNLC-EVLLHDCDACA------------------TDAECDSIQ 2494
+E+ + S+ NL E+ D T + IQ
Sbjct: 2812 ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2871
Query: 2495 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT--AAFPSSS 2552
+++ ++ + + ER+ ++ ++ + + WL+S E + SS
Sbjct: 2872 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSS 2931
Query: 2553 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-ARENRTDSACSLKQMVHEGNQ 2611
K + + +AF ++ + +++ + + L + A + K++ E N
Sbjct: 2932 PTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNS 2991
Query: 2612 RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL---------TNIEHFS 2662
RW+ + + R+L+ F+ A + WL E +L + N+ +
Sbjct: 2992 RWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 3051
Query: 2663 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 2722
+ VQ +K+ +A +Q+ H ++ + AQG L + +++EL + + E
Sbjct: 3052 KQQVQFMLKEFEARRQQ----HEQLNEA-AQGILTGPGDVSLSTSQVQKELQSINQKWVE 3106
Query: 2723 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS-NL 2781
+ ++ ++ + + ++ ++L + A L S S +S QP +
Sbjct: 3107 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL-----SVQSAISTQPEAVKQ 3161
Query: 2782 SLSLAQPLRSE-----RSGRDTPASVDSIPLEWDHDY---DLSRDLESAMSRALPSED-E 2832
L +RS+ ++ D + + Y +L + LE+ ALP + E
Sbjct: 3162 QLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV---ALPLQGLE 3218
Query: 2833 EGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENI-IRSKTPTGPELD 2891
+ D+ L+ A+ + + ++R LDD Q QQ +N I +K
Sbjct: 3219 DLAADRINRLQAALASTQQFQQMFDELRTW---LDDK--QSQQAKNCPISAKLERLQSQL 3273
Query: 2892 TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQ 2951
+ + K L + S S + + L S+P + + Q + + WE L +
Sbjct: 3274 QENEEFQKSLNQHSGSYEVIVAEGESLLL---SVPPGEEKRTLQNQLVELKNHWEELSKK 3330
Query: 2952 ALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKE 3011
++ R+K +QK Q++ + + W+ D + ++ +L+ ++ D +E + + K
Sbjct: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKA 3387
Query: 3012 LQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQD 3071
+ V+ R++++ +N + + + ++D + +N D V L+ G L++
Sbjct: 3388 MLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEE 3447
Query: 3072 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES-Q 3130
+ + F E + + ++ K+++ D+ L ++ + + + ++ + E+L++ +
Sbjct: 3448 MTQRLREFQESFKNI---EKKVEGAKHQLEIFDA-LGSQACSNKNLEKLRAQQEVLQALE 3503
Query: 3131 LRVASLQDMSCQLLVNA-EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----- 3184
+V L++ + L+ +A +G+D + + V + + V+ +E L
Sbjct: 3504 PQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQ 3563
Query: 3185 ------DVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQ 3220
++ S DL DELD G++ GR T + Q
Sbjct: 3564 FHCRVREMFSQLADLD-----DELDGMGAI----GRDTDSLQ 3596
Score = 108 bits (269), Expect = 1e-22
Identities = 253/1468 (17%), Positives = 564/1468 (38%), Gaps = 208/1468 (14%)
Query: 21 LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIE--KAKVLAHGTI 78
L K + E ++ R+ +++ A ++Y + + L W+ K K++A G I
Sbjct: 4185 LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI 4244
Query: 79 AWNSASQLREQYILHQTLLEESKEID--SELEAMTEKLQYLTSVY--CTEK----MSQQV 130
+L + Q ++++ ID ++M E + + ++ C E+ + ++
Sbjct: 4245 ------RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 4298
Query: 131 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQAT---LTSPEVGRL 187
L ++ E + + R L+ A + +F ++L +E+ +A L SP +
Sbjct: 4299 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 4358
Query: 188 SLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQ 247
L++Q + L + KP + + L+ + + + + ++++
Sbjct: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM-VEEKYQKAENMYAQIK 4417
Query: 248 HTAIQQCNIMQAAVVQYEQ---YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISR 304
Q+ + AV Q Q + +++ + + +E + P+ + + +++ IS
Sbjct: 4418 EEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISD 4477
Query: 305 HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGT----EDLDGELL 360
++ +++ Q +L + + L +++ A L E++ + ED+
Sbjct: 4478 NKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4537
Query: 361 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 420
V+ + + + + +T + ++ SP ++ I
Sbjct: 4538 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP--------------GIDPSI 4583
Query: 421 AYYQALSAERLQTDAAKIHPSTS-----ASQEFYEPGL--EPSATAKLGDLQRSWETLKN 473
Q +AE ++ + +H + + G +P + ++ +WE L
Sbjct: 4584 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNK 4643
Query: 474 VISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG---RSPESQMAEHQAL 530
E+ L +A++ +YQD+LQ++ ++ +KL P G + + Q+ E +
Sbjct: 4644 TWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF 4703
Query: 531 MDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQ 590
E+ Q E+ +L E ++ ++ D ++ ++ LT L + K + ++
Sbjct: 4704 KVEVYQQQIEMEKLNHQ-GELMLKKA--TDETDRDIIREPLTELKHLWENLGEKIAHRQH 4760
Query: 591 LLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD- 649
LE L AL +++ +EL SWL T+ LD +P +E +L
Sbjct: 4761 KLEGAL----------LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
Query: 650 --CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRAL 707
+N ++ + V +++ N LLE A D+A L +L + + +
Sbjct: 4811 HVLKNDVLAHQATVETVNKAG----NELLESSA--GDDASSLRSRLEAMNQCWESVLQKT 4864
Query: 708 HDKQLNMQGTAQEKE--ESDVDLTATQSPGVQEWLAQARTT--WTQQRQSSLQQQKELEQ 763
+++ +Q T Q+ + S+++ + ++ L+ ++ T + + L EL
Sbjct: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4924
Query: 764 ELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE-----LGMEGEKSSAEDQ 818
+L ++ + +G +L+ + + + +L Q+ ME KS E+
Sbjct: 4925 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984
Query: 819 MRM--KWESLHQEF--------------STKQKLLQNVLEQEQEQVLYSRP-----NRLL 857
+ + ++++ QEF S +L VL Q +E +++ ++++
Sbjct: 4985 LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 5044
Query: 858 ----SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSGGAKRQSIHLEQKLYDG 910
+G L K QD + +LL + +E+V S + G + + ++ ++
Sbjct: 5045 ELDQTGNQL-KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103
Query: 911 VSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKEMSEEMD---------K 959
WL+D E L + P++ + L + K + D K
Sbjct: 5104 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALK 5163
Query: 960 NKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKV 1019
K L PE+ D LG + V + + + +L++ L F
Sbjct: 5164 EKTL----LPEDSQKLD-------NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMD 5212
Query: 1020 LFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFD------AGIIELKRRGDK 1073
+L D Y + +LA +QPV ++ + D K F G +++ +R +
Sbjct: 5213 ALQALVDWLYKVEPQLAE--DQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGR 5270
Query: 1074 LQVEQPS------MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLE 1127
+E +L +L +D + + S++S L Q L + + L + L
Sbjct: 5271 ELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLS 5330
Query: 1128 TGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI--------------------- 1166
++ + + + E +Q L+D HKE+ + +E +
Sbjct: 5331 EAEQTLR-FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI 5389
Query: 1167 --------LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSH- 1217
+ F +++++A Q + + T L S ++ A L +I W+
Sbjct: 5390 TTIKHWITIIRARFEEVLTWAKQHQQRLETAL----SELVANAELLEELLAWI--QWAET 5443
Query: 1218 --LDEDQQELSRQLEVVESSIPSVGLVEENEDRL---IDRITLYQHLKSSLNEYQPKLYQ 1272
+ DQ+ + + ++ V++ I E R +DR+T K+ + P + +
Sbjct: 5444 TLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK 5503
Query: 1273 VLDDGKRLLIS--------ISCSDLES-QLNQLGECW-------LSNTNKMSKELHRLET 1316
G++ L +S S+ ++ ++NQL W L K++ L RLE
Sbjct: 5504 SRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE 5563
Query: 1317 ILKHWTRYQSE--SADLIHWLQSAKDRL 1342
LK + + + + W+ K R+
Sbjct: 5564 -LKEFANFDFDVWRKKYMRWMNHKKSRV 5590
Score = 52.4 bits (124), Expect = 7e-06
Identities = 116/685 (16%), Positives = 267/685 (38%), Gaps = 61/685 (8%)
Query: 3 LDAAVQKFLEQN-GQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
++ A + LE + G L ++ + + + +++ E R +L + ++ +E
Sbjct: 4827 VNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE 4886
Query: 62 -LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLT-- 118
+L+ L+ REQ H L + K + + +K + +
Sbjct: 4887 DFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS 4946
Query: 119 --SVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ 176
K Q VA L ++ + ++ R L++A +F+ L++ L A+
Sbjct: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
Query: 177 ATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKVQAVQLCQSALRIP-----EDVVASL 230
+L L L LS +H + E + Q ++L Q+ ++ +DVV
Sbjct: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL-- 5064
Query: 231 PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPV 290
+ + + +Q ++ +I++ + A + +Q+ + K L +E A ++ +
Sbjct: 5065 -IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 5123
Query: 291 ATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE 350
+++ +++ Q+S+H+E + + G Q + T++ A T+ L E
Sbjct: 5124 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDT--------TIRTGRALKEKTL-----LPE 5170
Query: 351 GTEDLDGELLPTPSAHPSVVMMTAGRCH-----TLLSPVTEESGEEGTNSEISSPPACRS 405
++ LD L +V + R H L S ++ + + P
Sbjct: 5171 DSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAE 5230
Query: 406 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAK--LGD 463
PV + D + ++ + + L + + +E E + + K L +
Sbjct: 5231 DQPV-HGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 5289
Query: 464 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKL---SESPEPGRSP 520
L W+T+ + KQ L +AL++ + ++D++ + + E L P+ +
Sbjct: 5290 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEAL 5349
Query: 521 ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMST 580
+S + H+ M ++ + ++N + E++ C D ++ +T++ R
Sbjct: 5350 QSLIDTHKEFMKKVEEKRVDVN--SAVAMGEVILAVCHPDCI--TTIKHWITIIRARFEE 5405
Query: 581 IRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP 640
+ A +Q LE L++ + +EL +W+ + TL + +EP
Sbjct: 5406 VLTWAKQHQQRLETALSELVANAEL----------LEELLAWIQWAETTL---IQRDQEP 5452
Query: 641 MD-----MEAQLMDCQNMLVEIEQK 660
+ ++A + + Q + E+ +K
Sbjct: 5453 IPQNIDRVKALIAEHQTFMEEMTRK 5477
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 270 bits (690), Expect = 2e-71
Identities = 613/3315 (18%), Positives = 1281/3315 (38%), Gaps = 365/3315 (11%)
Query: 8 QKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI 67
QK L+ + K+ ++ L + ++ A R + L+ + L + L ++L
Sbjct: 1880 QKVLDMENSFKE--GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSH---LNMLLGQY 1934
Query: 68 EKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQ-----YLTSVYC 122
+ + A AW A + + +L T+ + + +L A T++LQ + V
Sbjct: 1935 HQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL-ATTKQLQEELAEHQVPVEK 1993
Query: 123 TEKMSQQVAELG-------RETEELRQMIKIRLQNL-----------QDAAKDMKKFEAE 164
+K+++ + E+ R +E I Q+L Q A + +
Sbjct: 1994 LQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2053
Query: 165 LKKLQAALEQAQATLTSPEVGRLS---LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALR 221
L+ L ++ + + L +V LS ++E L+ L ++ K ++A + +
Sbjct: 2054 LESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM 2113
Query: 222 IPEDVVASLPLCHAALRLQEEASRLQHTAIQQC---NIMQAAVVQYEQYEQEMKHLQQLI 278
D + L +L E + R + +QQ + ++ + Q E +E LQQ +
Sbjct: 2114 ETADSTTAAVLQG---KLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM 2170
Query: 279 EGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLN------SKC------ 326
E R + +I QI +EL +++ QE + +L S C
Sbjct: 2171 ENKSRMLASGNQPDQDITHFFQQI---QELNLEMEDQQENLDTLEHLVTELSSCGFALDL 2227
Query: 327 -----KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRC---H 378
++ ++ + TV E E A ++ E + T G
Sbjct: 2228 CQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTE 2287
Query: 379 TLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 438
T +S E E S + + + N + +++ ++A Q I
Sbjct: 2288 TSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLI--MEITAPDSQGKTGSI 2345
Query: 439 HPSTSAS----QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
PS +S ++ + D+ +E L V+ E+Q +L L R ++
Sbjct: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405
Query: 495 SLQSISTKMEAIELKLSE-----SPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLA 549
S+ +E+ E L SP + ++Q ++A + E+ +I +++ +LA
Sbjct: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
Query: 550 EELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQAL 609
LV+ + +Q L ER + + + QLEE A
Sbjct: 2466 GLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR-----------QLEESASHLAC 2514
Query: 610 QRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSV 669
++ +L WL+ + + +P + AQ Q ML E E + +L+
Sbjct: 2515 --FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 2572
Query: 670 HNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDK-----QLNMQGTAQEKEES 724
+ +L G Q+ +L+ + +EL L+ + Q ++ T ++
Sbjct: 2573 AAQGILT-GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ 2631
Query: 725 DVD---LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQ---ELAEQKSLLRSVASR 778
D+ Q VQ ++ QQ + + + + +LEQ E+ E ++L ++
Sbjct: 2632 DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVL 2691
Query: 779 -GEEIL-------IQHSAAETSGD---AGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 827
GE+ L ++ A G A ++ + L L + D++R +
Sbjct: 2692 IGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQ 2751
Query: 828 QE------FSTKQKLLQNVLEQEQE------------QVLYSRPNRLLSGVPLYKGDVPT 869
+ S K + LQ+ L++ +E +V+ + LL VP P
Sbjct: 2752 SQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVP------PG 2805
Query: 870 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-----IHLEQKLYDGVSATSTWLDDVEER 924
++K + + L L +EE+S ++ A RQS + QK V W++D + +
Sbjct: 2806 EEKRTLQNQLVELKNHWEELSKKT--ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAK 2863
Query: 925 LF-VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLG 983
+ + L P + E+ L + + ++++ ++ + + + D I D
Sbjct: 2864 MSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKA 2923
Query: 984 CLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII-------LQKLA 1036
+ + + + + ++E Q++ FQ K + + K+ + Q +
Sbjct: 2924 GINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS 2983
Query: 1037 NVFEQPVAEQIEAIQQAE---DGLKEFDAGIIELKRRGDK----LQVEQPSMQELSKLQD 1089
N + + Q E +Q E D L+ F G++E G L + + QE +++
Sbjct: 2984 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQ 3043
Query: 1090 MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQ 1149
+ +++ ++ G+ Q + L DL D L+ G + D + S E+++
Sbjct: 3044 RVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD-GMGAIGRDTDSLQSQIEDVRL 3102
Query: 1150 LLDKHKEYFQGLES------HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 1203
L+K +E+ HM+ E + +++E + L Q + +R
Sbjct: 3103 FLNKIHVLKLDIEASEAECRHMLEEEGTLDLL---GLKRELE---ALNKQCGKLTERGKA 3156
Query: 1204 RGVELEYIL---ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 1260
R +LE L E + + + + E E+ VG E ++ + ++Q K
Sbjct: 3157 RQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQ--K 3214
Query: 1261 SSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKELHRLET 1316
++ Q KL QV G+ L+ S LE + ++ W + K+++ + +L+
Sbjct: 3215 EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQE 3274
Query: 1317 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 1376
L H ++Q L+ WL ++ + S E ++V+ + + +D +
Sbjct: 3275 ALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQEQKLLQRLLDDR 3330
Query: 1377 SSLKSSVLSTGNQLLRLKKV-DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 1435
+ + + G ++ + ++ D + +L ++S+WT+LL+ A Q++L + +
Sbjct: 3331 KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQ 3390
Query: 1436 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKIDINCKQLTVDF 1493
+ ++S+ E + E +G + I + + ++K + DI V
Sbjct: 3391 FHETAEPISDFLSVTEKKLANSEP-----VGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
Query: 1494 ---VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSE 1550
+ QS+ ++S + S+K D ++ + +Q K LL+ L +
Sbjct: 3446 AVKIGQSLSSLTSPAEQGVLSEKID------SLQARYSEIQDRCCRKAALLDQALSNARL 3499
Query: 1551 Y-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG 1609
+ E+ V+ L E ++K + Q + D L + I ++K V++ +NG
Sbjct: 3500 FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNG 3559
Query: 1610 LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSY 1669
AL++ + ++ L + +A++ + L+ + + ++++ +
Sbjct: 3560 QALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 3619
Query: 1670 LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKEC 1725
L E L+ +G Q+ Q Q +L+K+ L ++ LL+
Sbjct: 3620 LREVEEELAT----SGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELV 3675
Query: 1726 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 1785
E L + + N ++ + + I +++ A +Q Q+Y+ Q A
Sbjct: 3676 PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWVAE 3731
Query: 1786 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 1845
T L A + D+ +Q + KDS+ L ++ +
Sbjct: 3732 TKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTV 3791
Query: 1846 IQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 1905
+Q SL Q A+ ++ L+ + F ++ E L WI E ++ Q PS
Sbjct: 3792 LQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALI-AQLPS 3850
Query: 1906 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LNDKE----IKRMQNLNRH 1960
+ D ++++ EE++ + P +D+L ++G +L LN +E ++ Q
Sbjct: 3851 PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENM 3910
Query: 1961 WSLISSQTTERFSKLQSFLLQHQT---FLEKCETWMEFLVQTEQKLAVE--ISGNYQHLL 2015
++ I + +R L + Q F +K E +E L +L + I +
Sbjct: 3911 YAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 3970
Query: 2016 EQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLKLTLLSNQWQGV 2071
E ++ E+ Q ++ G+ L+ + Q D+D E KL + W+ +
Sbjct: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030
Query: 2072 IRRAQQRR----GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ--QAR 2125
RA++R +++ + W + ++ V L G+ I Q A
Sbjct: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
Query: 2126 TLFDEVQ--FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM 2183
T+ +E +E F+R G+ L+ + + ++ + E+ W++ +
Sbjct: 4091 TIKEETDGLHEELEFIRILGA---------DLIFACGETEKPEVRKSIDEMNNAWENLNK 4141
Query: 2184 RLEEQKKKLAFLLK---DWEKCEKGIADSLEK--------------LRTFKKKLSQSLPD 2226
+E+ +KL ++ ++ + + D L+ L T K +L++ + +
Sbjct: 4142 TWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE-MKE 4200
Query: 2227 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE 2286
E++ +Q+ ++L + +L L K T D I+ E + L+ WE
Sbjct: 4201 FKVEVYQQQIEMEKLNHQ--------GELMLKKAT-----DETDRDIIREPLTELKHLWE 4247
Query: 2287 ELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ----NGDILIEEMIEKL 2342
L +++ R+ ++ L F +EL WLT E + +GD + E +E
Sbjct: 4248 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE-VELA 4306
Query: 2343 KKDYQEEIAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 2401
K + +A + ++ + + G L ++S AS + +L +N W+ +L R
Sbjct: 4307 KHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEERE 4366
Query: 2402 KKLKETLVAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRD 2459
++L+ TL Q + L +ES+L+ KP E + +L+ EL
Sbjct: 4367 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT---GGLPETAREQLDTHMELYSQ 4423
Query: 2460 IEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE 2519
++ +L+ ++L D + ++ + Q+ L+++W + + ER+ K+E
Sbjct: 4424 LKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVSSKMEERKSKLE 4480
Query: 2520 ETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ 2579
E L +F + F +WL +E++ S +I ++++ + F +V+ Q
Sbjct: 4481 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 4540
Query: 2580 LELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 2639
+ +++ +L ++ +K ++ RW+ + +R R L + ++F
Sbjct: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 4600
Query: 2640 ARDSILVWLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 2697
A ++ WL + + L + +E ++ D ++ ++ + K FQ+ + + I G L
Sbjct: 4601 AWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL 4660
Query: 2698 IEKS-EPLDAAIIEEELDELRRYCQEVFGR-VERYHKKLIRLPLPDDEHDLSDRELE--- 2752
EK+ P D+ ++ L E+R V G+ VER HK L D ++
Sbjct: 4661 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 4720
Query: 2753 ------LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD--------- 2797
ED DL D+ Q Q L+ RSGR+
Sbjct: 4721 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK--RSGRELIENSRDDT 4778
Query: 2798 --TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE---------EGQDDKDFYLRGAV 2846
+ + WD LS +S + +AL + E + + LR
Sbjct: 4779 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 4838
Query: 2847 GLSGDHSALESQI---RQLGKALDDSRFQIQQT----ENIIRSKTPTGPELDTSYKGYMK 2899
L D AL+S I ++ K +++ R + E I+ P+ T+ K ++
Sbjct: 4839 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL---AVCHPDCITTIKHWIT 4895
Query: 2900 LLGECSSSIDSVKRLEHKL---KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 2956
++ R E L K+ ++ L ET + ++ ELL+ +
Sbjct: 4896 IIR---------ARFEEVLTWAKQHQQRL---------ETALSELVANAELLEELLAWIQ 4937
Query: 2957 LRMKQNLQKWQQ-FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKEL--- 3012
+Q+ Q+ +++ + A + + + +E++ R + D T + K ++
Sbjct: 4938 WAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAP 4997
Query: 3013 ---QKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLL 3069
+ RK++ P +Q+++K R++Q++ RW +V L E + L
Sbjct: 4998 FIEKSRSGGRKSLSQPTPPPMPILSQSEAK-----NPRINQLSARWQQVWLLALERQRKL 5052
Query: 3070 QDALMQCQGFHEMSH 3084
DAL + + E ++
Sbjct: 5053 NDALDRLEELKEFAN 5067
Score = 259 bits (662), Expect = 3e-68
Identities = 639/3366 (18%), Positives = 1347/3366 (40%), Gaps = 408/3366 (12%)
Query: 4 DAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE----YNEM 59
DA Q+F++ L + L L Q ++ + L +L + +EE + E
Sbjct: 1379 DAITQEFMD--------LRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEK 1430
Query: 60 LELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEE---SKEIDSELEAMTEKLQY 116
++ +L W+ LA T ++S+ +E + + +LE+ S+E+ ++ E ++E ++
Sbjct: 1431 VKELLGWVS---TLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIK- 1486
Query: 117 LTSVYCTEKMSQQVAELGRE--TEELRQMIKIRLQNLQDAAKDMKKFEAEL--KKLQAAL 172
TS K +++E ++ +E+L + K +A +++ +++L + Q L
Sbjct: 1487 -TSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTL 1545
Query: 173 EQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPL 232
++ Q T S Q + R + + + + A+Q QS L+ +D + +
Sbjct: 1546 QKQQNTCHQQLEDLCSWVGQ-AERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRAT 1604
Query: 233 CHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVAT 292
A + E ++ + A + Q +++ + LQ+ A +E+E+ T
Sbjct: 1605 SFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEE--AVT 1662
Query: 293 SNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGT 352
S +Q+ + +ELA+ K +++ +T LLT G
Sbjct: 1663 SALQQETEKSKAAKELAENKK-------KIDALLDWVTSVGSSGGQLLTNLP------GM 1709
Query: 353 EDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANT 412
E L G L + + G G N ++P +
Sbjct: 1710 EQLSGASLEKGALDTT-------------------DGYMGVN---------QAPEKL--- 1738
Query: 413 DASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQ 465
D A +Q L +++ A T ++Q F + P + KLG+L+
Sbjct: 1739 DKQCEMMKARHQELLSQQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELK 1793
Query: 466 RSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---S 522
+ T + + + + QK+ + + +E E +L + G SPE S
Sbjct: 1794 EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPS 1853
Query: 523 QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERM 578
+ + ++++ + ++ + S + L E+ + E + + L ER
Sbjct: 1854 LLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 1913
Query: 579 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP- 637
+ + K + L LN L + Q ++ AD L +W+ + +A ++ LS
Sbjct: 1914 TALHSKCTR----LGSHLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTV 1963
Query: 638 -KEPMDMEAQLMDCQNMLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLA 690
+P ++ QL + + E+ + V + +L V + + +EG+ H ++ + +
Sbjct: 1964 ASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSIL 2023
Query: 691 GKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQ 750
+ L SL E + +L K + + QE ES QS G E + + +
Sbjct: 2024 SHFQSLSYSLAE-RSSLLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLS 2077
Query: 751 R---QSSLQQQKELEQELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQ 804
Q +L +L+Q++A QKS L R + +R E +AA G E Q
Sbjct: 2078 SGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137
Query: 805 ELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYK 864
+ EK S+ ++ + E + + S K LQ +E + L
Sbjct: 2138 LCLQQQEKESSLKKLLPQAE-MFEHLSGK---LQQFMENKSRM--------------LAS 2179
Query: 865 GDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEER 924
G+ P QD + + LN E+ +++++ + L +S+ LD + +
Sbjct: 2180 GNQPDQDITHFFQQIQELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQ 2231
Query: 925 LFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGC 984
V L + TE +E KD E++D+ + L + +++T G
Sbjct: 2232 DRVQN-LRKDFTELQKTVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG- 2281
Query: 985 LLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVA 1044
S+ + + +++++++ + + +D T + + + E +
Sbjct: 2282 -----SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIM 2331
Query: 1045 EQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRS 1103
E Q + G G G + +Q ++S + Y++L ++ R+
Sbjct: 2332 EITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2391
Query: 1104 GLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLE 1162
L L + + + LE+ +E + + +K E ++ + +K + LE
Sbjct: 2392 SLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE 2451
Query: 1163 SH----MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSH 1217
+ + E L ++++ +E + ++ + ++ +RA + V + LE + SH
Sbjct: 2452 QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511
Query: 1218 L---DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVL 1274
L + +L L E + +G + + + L + Q + + + Q+
Sbjct: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLN 2571
Query: 1275 DDGKRLL-----ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESA 1329
+ + +L +S+S S ++ +L + + W+ T+K++ +++ + T+YQ
Sbjct: 2572 EAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ 2631
Query: 1330 DLIHWLQSAKDRLEFWTQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLS 1385
DL +++ RL + Q V Q+LE + + + EV +AQ+ +
Sbjct: 2632 DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVL 2691
Query: 1386 TGNQLLR---LKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISE 1442
G Q L+ K+++T L L ++ D + + A Q Q E
Sbjct: 2692 IGEQYLKDELKKRLETVAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDE 2742
Query: 1443 VMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVL 1499
+ +W+ ++ K N S + + LQ+ + F+ +N + + + +S+L
Sbjct: 2743 LRTWLDDKQSQQAK---NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL 2799
Query: 1500 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 1559
+S E KR+ QL + W+ L ++ L+ ++ +Y+ +V+ L
Sbjct: 2800 -LSVPPGEEKRT----LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLV 2854
Query: 1560 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 1619
W E + ++ + D ++++L + + + ++ + +E + LI + + D
Sbjct: 2855 PWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD 2914
Query: 1620 VSSI----------VMSTLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-F 1663
I + + EL +L+ M +L+ +S + + + H++ F
Sbjct: 2915 EDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF 2974
Query: 1664 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 1723
D + S + +L + R L+A++ QVD L+N L + GS +QLL
Sbjct: 2975 DALGSQACSNK-NLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLH 3029
Query: 1724 ECHPPVTETLTNTLKEVNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS------- 1772
+ E L EV R N+ ++E E + Q + +++ + D
Sbjct: 3030 QAEVAQQEFL-----EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMG 3084
Query: 1773 ---KQCASTVQQQEDRTNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLH 1828
+ S Q ED L K K DI E +C +L+ GT+ D L
Sbjct: 3085 AIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKR 3138
Query: 1829 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEAL 1888
EL KQ + + +QL L+ L +E K + G+ D T A+ EAL
Sbjct: 3139 ELEALNKQCGKLTERGKARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEAL 3191
Query: 1889 EAWIVEAE-EILQGQDPSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPL 1946
+ W+V E EI+ Q +D Q E+++ L+ ++ + + + L + G +
Sbjct: 3192 Q-WVVGTEVEIINQQ----LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDV 3244
Query: 1947 NDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE 2006
E M+ +N W+ ++ + +R ++LQ LL F + E + +L TE+ +A +
Sbjct: 3245 QGLE-HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3303
Query: 2007 I--SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLL 2064
S Y+ + Q + +L Q + R+ + + +G R+ + ++ DR++ +L L
Sbjct: 3304 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3363
Query: 2065 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 2124
++W ++ +A R+ ++ + +++ E AE + +L S S P+ Q A
Sbjct: 3364 ESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTA 3420
Query: 2125 RTLFDEVQFK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEI 2174
+ ++ K E+ V+ G Q L S S AE +LQA +EI
Sbjct: 3421 KIQQQIIRHKALEEDIENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEI 3479
Query: 2175 QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHE 2229
Q++ + L++ +D + +A+ +KL + FK+ + H
Sbjct: 3480 QDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHL 3539
Query: 2230 ELHAEQM-RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEEL 2288
L+ E + R K ++ A+ + +LLK T + +++ ++ E+++ ++ ++ ++
Sbjct: 3540 ALNEEIVNRKKNVDQAIKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADI 3588
Query: 2289 CHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQ 2347
S + + + F +EL WL ++E +++ +G E I + ++ +
Sbjct: 3589 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQK 3648
Query: 2348 EEIAIAQENKIQLQQMGERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKK 2403
E E+++ L + E +++A E +A E ++ + N++++ + D I RV +
Sbjct: 3649 ELKKEVMEHRLVLDTVNE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707
Query: 2404 LKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIE 2461
+ + QQ ++ + W+A + +L PI + ++ +L Q+ DI
Sbjct: 3708 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDII 3764
Query: 2462 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEET 2521
+H + + + + C + + +Q+ T +L +++ I ++ ER ++E
Sbjct: 3765 RHKDSMDELFSHRSEIFGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 3820
Query: 2522 WRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLE 2581
L +F + Y W++ + A S + + +++ ++ + + E ++
Sbjct: 3821 QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHID 3880
Query: 2582 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEF 2637
+ K +L N + +MV E Q+ +N+ ++ +R+ L + Q +
Sbjct: 3881 KLLKIGPQLKELNPEEG-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQI 3935
Query: 2638 ETARDSILVWLTEMD----------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKI 2687
D I L ++ L ++ EC I K+ E+
Sbjct: 3936 TEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSF 3990
Query: 2688 EQIIAQGEQLIEKSEPLD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDE 2743
E + +GE+LI +S+ D A I+++LD++ + +++ R E
Sbjct: 3991 EALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE--------------- 4035
Query: 2744 HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVD 2803
+RE++ D L++ W+D +A L + + + ++ L P + + +
Sbjct: 4036 ----EREIKFLDVLELAEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
Query: 2804 SIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLG 2863
+I E D L +LE G+ +K + ++ L ++
Sbjct: 4091 TIKEETD---GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERL 4147
Query: 2864 KALDDSRFQIQQTENIIRS----------KTPTGPELDTSYKGYMKLLGECSSSIDSVKR 2913
+ L+D+ Q ++ +++ K T P + T L E V+
Sbjct: 4148 EKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEV 4205
Query: 2914 LEHKLKEEEESLPGFVNLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQ 2964
+ +++ E+ + G + L +T I R WE L + ++ +++ L
Sbjct: 4206 YQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL 4265
Query: 2965 KWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIIL 3024
QF L + +WL TEE L+ + +S D + IE+++ K L+ V +A +
Sbjct: 4266 ALGQFQHALEELMSWLTHTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVE 4323
Query: 3025 SINLCSPEFTQADS-KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS 3083
++N E ++ + ++ L+ RL MN W+ V EE LQ L Q QGFH
Sbjct: 4324 TVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEI 4383
Query: 3084 HGLLLMLENIDRRKNEIVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVAS 3135
LL L ++ + + P E L H + Q+K ++LL+ +
Sbjct: 4384 EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLL 4443
Query: 3136 LQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSS 3195
+D S + LE +K HV+ ++++ + S+ + L + +S Q+ +
Sbjct: 4444 SRDDSGSGSKTEQSVALLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFIN 4498
Query: 3196 WSSADE 3201
W + E
Sbjct: 4499 WLTLAE 4504
Score = 246 bits (629), Expect = 2e-64
Identities = 604/3381 (17%), Positives = 1317/3381 (38%), Gaps = 406/3381 (12%)
Query: 46 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 105
+NQA L++ EM++ + E + +A SA +Q+ H EE + +
Sbjct: 1731 VNQAPEKLDKQCEMMKA--RHQELLSQQQNFILATQSAQAFLDQHG-HNLTPEEQQMLQQ 1787
Query: 106 ELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAEL 165
+L + E QY TS+ +E +QV L E LQ +D K+FE+ L
Sbjct: 1788 KLGELKE--QYSTSLAQSEAELKQVQTLQDE--------------LQKFLQDHKEFESWL 1831
Query: 166 KKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV---QAVQLCQSALRI 222
++ + LE +SPE LK Q S + ++S L+ Q V +++ +
Sbjct: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891
Query: 223 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI-MQAAVVQYEQYEQEMKHLQQLIEGA 281
++ L L+ E H+ + + + QY Q++ LQ ++
Sbjct: 1892 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 1951
Query: 282 HREIED--KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATML 339
+E S+ LQ Q++ ++L +++ +Q + L +
Sbjct: 1952 EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR------------ 1999
Query: 340 LTVTEVEGLAEGTEDLDGELLPTPSAH-PSVVMMTAGRCHTLLSPVTE-ESGEEGTNSEI 397
+ E+EG E + +H S+ A R L + + +S +E S +
Sbjct: 2000 -DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058
Query: 398 SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEP-- 455
S + +S++ + + +L+ D A+ S A++E +E
Sbjct: 2059 QSIGEVEQ-NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETAD 2117
Query: 456 SATA-----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKL 510
S TA KL ++ + +E L EK+ +L + L + + ++ +S K++
Sbjct: 2118 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQFMENK 2173
Query: 511 SESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 570
S G P+ + + E+ + ++ E +L E LV+E A L
Sbjct: 2174 SRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL-EHLVTELSSCGFALDLCQHQ- 2231
Query: 571 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 630
+R+ +R + ++ ++E+ D Q Q L +R WL T+ ++
Sbjct: 2232 -----DRVQNLRKDFTELQKTVKEREKDASSCQEQ---LDEFRKLVRTFQKWLKETEGSI 2283
Query: 631 DTALSPPKEPM----DMEAQLMDCQNMLVEIEQKVVALSELSVHN---ENLLLEGKAHTK 683
PP E ++E Q+ +++L + K + E++ ENL++E T
Sbjct: 2284 -----PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME---ITA 2335
Query: 684 DEAEQLAGKLRRLKGSLLELQRALHD-KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ 742
+++ G + GS + H K L T + + SDV+L + GV
Sbjct: 2336 PDSQGKTGSILPSVGSSVGSVNGYHTCKDL----TEIQCDMSDVNLKYEKLGGV------ 2385
Query: 743 ARTTWTQQRQSSLQQ-QKELEQELAEQKSLLRSVASRGEEILIQHSA------AETSGDA 795
+RQ SLQ +E+ E S+L+ + S+ EE+L A ET
Sbjct: 2386 -----LHERQESLQAILNRMEEVHKEANSVLQWLESK-EEVLKSMDAMSSPTKTETVKAQ 2439
Query: 796 GEKPDVLSQELGMEGEK-------------SSAEDQMRMKWESLHQEFSTKQKLLQNVLE 842
E EL K + Q W+ + +E +++ + V
Sbjct: 2440 AESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTV 2499
Query: 843 QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIH 902
Q Q+ S + + +K + +L L+ + A++Q +
Sbjct: 2500 ARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS-----IDPNMLNAQKQQVQ 2554
Query: 903 LEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKN 962
K ++ L++ + + + T + + + E++++++ +
Sbjct: 2555 FMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSS 2614
Query: 963 LFSQAFPENGDNRDVIEDTLGCL--LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020
QA ++ +++++D + +G+ + S ++ + +K++L++ ++DL+ L
Sbjct: 2615 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQL 2674
Query: 1021 FTSLADNKYIILQKLANVFEQPVAEQI----EAIQQAEDGLKEFDAGIIELKRRGDKLQV 1076
+ + + + + + EQ + +++ E + GL++ A D++
Sbjct: 2675 DHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAA---------DRINR 2725
Query: 1077 EQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE--KMA 1134
Q ++ + Q M+DEL + ++S +N + ++ ER L + E + + +
Sbjct: 2726 LQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHS 2785
Query: 1135 GDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQA 1194
G ++IV+ E + + +E TL +++ E + H E +++
Sbjct: 2786 GSYEVIVAEGESLLLSVPPGEE-----------KRTLQNQLV------ELKNHWEELSKK 2828
Query: 1195 SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRL---ID 1251
+A + S L + Q+ + VE +P + + L +D
Sbjct: 2829 TA----------------DRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLD 2872
Query: 1252 RITLYQHL---KSSLNEYQPK--LYQVLDDGKRLLISISCSD---LESQLNQLGECWLSN 1303
+ L L K+ LNE + + L ++L+ +LI+ S +D + + + + +
Sbjct: 2873 PVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV 2932
Query: 1304 TNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ--QSVTVPQELEMVRD 1361
T ++ + LE + + +Q ++ ++ AK +LE + + LE +R
Sbjct: 2933 TEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA 2992
Query: 1362 HLNAFLEFSKEVDAQSSLKSSVL------STGNQLLRLKKVDTATLRSELSRIDSQWTDL 1415
+VD + ++ S +QLL +V R++S
Sbjct: 2993 QQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNS----- 3047
Query: 1416 LTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV--IQKDEDNIKNSIGYKAIHEY 1473
++ KL + R S++ ++ + I +D D++++ I + + +
Sbjct: 3048 --GCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQI--EDVRLF 3103
Query: 1474 LQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGL 1533
L K K+DI + + + E D +L A+NK L
Sbjct: 3104 LNKIHVLKLDIEASEAECRHMLE----------EEGTLDLLGLKRELEALNKQCGKLTER 3153
Query: 1534 VTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLED 1593
+ + LE L ++ ++ L E+ Q +G + + N Q L D
Sbjct: 3154 GKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIIN-----QQLAD 3208
Query: 1594 LIKAKEKEVEKIEQ-----NGLA--LIQNKKEDVSSIVMS-TLRELGQTWANLDHMVGQL 1645
++++V+ ++ NGL LIQ+ +D + + E+ W L+ V Q
Sbjct: 3209 FKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQR 3268
Query: 1646 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 1705
L+ L + A + + S+L + ++ + + + V+ Q+ + LQ L+
Sbjct: 3269 IAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLD 3328
Query: 1706 KQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLW 1765
++ ++ + ++ + E +T L+ + RW LL + A + + + +L L
Sbjct: 3329 DRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLA 3388
Query: 1766 QRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLF 1825
+++ + ++ + + E + T ++ D+ V ++
Sbjct: 3389 KQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAV- 3447
Query: 1826 FLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSL 1885
++G+ L + + SL ++ C++ L + + F +
Sbjct: 3448 ---KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 3504
Query: 1886 EALEAWIVEAEEILQG-------QDPSHS--SDLSTIQERMEELKGQMLKFSSMAPDLDR 1936
+ W+ E E+ L QD H +D + E + K + + L +
Sbjct: 3505 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLK 3564
Query: 1937 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFL 1996
G + L +++ ++ ++ SS+ + + + Q+ E+ W+
Sbjct: 3565 -QTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLR-- 3621
Query: 1997 VQTEQKLAVEISGNYQHLLEQ-----QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV 2051
+ E++LA SG EQ QR EL + E+ + +L ++ + LLE
Sbjct: 3622 -EVEEELAT--SGGQSPTGEQIPQFQQRQKEL-KKEVMEHRLVLDTVNEVSRALLELVPW 3677
Query: 2052 DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPM 2111
R+ + ++ + Q++ V QR ID+ I++ Q+Y + A+ W+ E M
Sbjct: 3678 RAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLM 3737
Query: 2112 SGLGSVPIPLQQARTLFD-EVQFKEKV-FLRQQGSYILTVEAGKQLLLSADSGAEAALQA 2169
+ LG PI L+Q +T +VQ + +R + S ++ + + LQ
Sbjct: 3738 A-LG--PIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQE 3794
Query: 2170 ELAEIQEKWKSASMRLEEQKKKL----AFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 2225
+ + +++++ S+ E+ +L + + WE E+ ++ +E+ R +L
Sbjct: 3795 KTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE-LSPWIEETRALIAQLPSPAI 3853
Query: 2226 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQW 2285
DH E+L +Q ++L ++ + +L + L ++ ++ ++ E+ + + +
Sbjct: 3854 DH-EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE-LNPEEGEMVEEKYQKAENMY 3911
Query: 2286 EELCHQLSLRRQQIGERLNEWAV---FSEKNKELCEWLTQMESKVSQNGDILIEEMIEKL 2342
++ ++ R + E +++ F +K + + E L + S++ LI ++K+
Sbjct: 3912 AQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP--LIPAEVDKI 3969
Query: 2343 KKDYQE-EIAIAQENKIQ-----LQQMGERLAKASH----ESKASEIEYKLGKVNDRWQH 2392
++ + + A + K+Q L++ GE L S + A EI+ KL ++ W+
Sbjct: 3970 RECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED 4029
Query: 2393 LLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNE 2452
+ R K + L ++ +M++L T + + IV+D + + +
Sbjct: 4030 IKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQD-----IVHDLESPGIDPSIIKQ 4084
Query: 2453 QQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSM 2512
Q E I++ + G+ L +L D + E ++++ ++ W N+
Sbjct: 4085 QVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWK 4144
Query: 2513 ERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQ 2572
ER K+E+ + ++ D DWL ++ G K++L + + F+ +
Sbjct: 4145 ERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVE 4204
Query: 2573 VHECLTQLELINKQYRRLARE--NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHF 2630
V++ ++E +N Q + ++ + TD +++ + E W+NL +++ +L+
Sbjct: 4205 VYQQQIEMEKLNHQGELMLKKATDETDRDI-IREPLTELKHLWENLGEKIAHRQHKLEGA 4263
Query: 2631 IGQREEFETARDSILVWLTEMDLQLTNIEHFSECD---VQAKIKQLKAFQQEISLNHNKI 2687
+ +F+ A + ++ WLT + +L + + D ++ ++ + + ++ + +
Sbjct: 4264 LLALGQFQHALEELMSWLTHTE-ELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATV 4322
Query: 2688 EQIIAQGEQLIEKSEPLDAAIIE--------------EELDELRRYCQEVFGRVERYHKK 2733
E + G +L+E S DA+ + ++ +E + Q + + +H +
Sbjct: 4323 ETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSE 4382
Query: 2734 ----LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 2789
L+ L + + S L ++A L H L + + + N L + +
Sbjct: 4383 IEDFLLELTRMESQLSASKPTGGLPETAR-EQLDTHMELYSQLKAKEETYNQLLDKGRLM 4441
Query: 2790 RSER----SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY---- 2841
R SG T SV + +W + +S + AL E ++F
Sbjct: 4442 LLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLT 4501
Query: 2842 ---------------LRGAVGLSGDH-------SALESQIRQLGKALDDSRFQIQQT--- 2876
L + +H +A QI +L + + +F Q+
Sbjct: 4502 LAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVV 4561
Query: 2877 -------------ENIIRSKTPTGPELDTSYK-------GYMKLLG-------------E 2903
E +++ G LD + K + KL+ E
Sbjct: 4562 LIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 4621
Query: 2904 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI--------------------- 2942
S+ D +K K KE +++L G ++ T +T +
Sbjct: 4622 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVR 4681
Query: 2943 DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 3002
D+W+ + +++ ++ ++++ L QF L ++ WL E +L + Q + D+
Sbjct: 4682 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMN 4741
Query: 3003 ELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLL 3062
+ K+ QK + R + + E + ++ ++ +L +++ RWD VC L
Sbjct: 4742 LMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLS 4799
Query: 3063 EEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLM 3120
+ L+ AL Q + F + H LL L ++ R +P D+ + L D HK+ M
Sbjct: 4800 VSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA-LQSLIDTHKEFM 4858
Query: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLLLKEVSRHIKE 3179
+ ++ E ++ V S M ++++ DC+ K + +I R + +L +H +
Sbjct: 4859 K---KVEEKRVDVNSAVAMG-EVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQR 4914
Query: 3180 LEKLLD--VSSSQ--QDLSSW 3196
LE L V++++ ++L +W
Sbjct: 4915 LETALSELVANAELLEELLAW 4935
Score = 216 bits (549), Expect = 4e-55
Identities = 613/3305 (18%), Positives = 1266/3305 (38%), Gaps = 514/3305 (15%)
Query: 60 LELILKW-IEKAKVLAHGTIAWNSASQLREQYILH-QTLLEESKEIDSELEAMTEKLQYL 117
L+L+ W +EK + A G Q+ + H + L++S+ DS L ++ ++L+
Sbjct: 967 LDLVQTWNLEKLRSSAPG-----ECHQIMKNLQAHYEDFLQDSR--DSVLFSVADRLRLE 1019
Query: 118 TSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQA 177
V + Q + + ++ + K+ + L++ ++++E + K +L ++
Sbjct: 1020 EEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRT 1079
Query: 178 TLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQL-CQSALRIPEDVVASLPLCHAA 236
+ + L + EQ +H +++ L+ + AV + C S L
Sbjct: 1080 DRDAWQDNALRIAEQ----EHTQEDLQQLRSDLDAVSMKCDSFLH--------------- 1120
Query: 237 LRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ 296
Q +S T + N++ ++M H+ L +++ V +IQ
Sbjct: 1121 ---QSPSSSSVPTLRSELNLLV----------EKMDHVYGLSTVYLNKLKTVDVIVRSIQ 1167
Query: 297 ELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD 356
+ + + +E IK QE++ + + ++A +T+ +++V+ LD
Sbjct: 1168 DAELLVKGYE-----IKLSQEEVVLAD----LSALEAHWSTLRHWLSDVKDKNSVFSVLD 1218
Query: 357 GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 416
E+ + +T R L E E+G+ + + S+
Sbjct: 1219 EEIAKAKVVAEQMSRLTPERNLDL-----ERYQEKGSQLQERWHRVIAQLEIRQSELESI 1273
Query: 417 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVIS 476
+ + Y+A + K T+A QE +PG + V+S
Sbjct: 1274 QEVLGDYRACHGTLI-----KWIEETTAQQEMMKPGQAEDS---------------RVLS 1313
Query: 477 EK---QRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDE 533
E+ Q L+ +ER Q D Q S + I + E Q+ ++A ++
Sbjct: 1314 EQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIV----------KDYELQLMTYKAFVE- 1362
Query: 534 ILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE 593
++ +S + S +A E + L++ T L + S + LE
Sbjct: 1363 --------SQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLE 1414
Query: 594 EKLNDQLEEQRQEQALQRYRCEADELDSWL--LSTKATLDTALSPPKEPMDMEAQLMDCQ 651
E EE+ E+ Q + + EL W+ L+ S KE D+E +++ Q
Sbjct: 1415 E------EEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQ 1468
Query: 652 NMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQ 711
+ E+ K +SE ++ + L H E E+ +++ L L +A HD
Sbjct: 1469 VLSEELTTKKEQVSE-AIKTSQIFLAKHGHKLSEKEK-----KQISEQLNALNKAYHDL- 1521
Query: 712 LNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQ-QQKELEQELAEQKS 770
D +A Q +Q LA Q Q +LQ QQ Q+L +
Sbjct: 1522 --------------CDGSANQLQQLQSQLAH------QTEQKTLQKQQNTCHQQLED--- 1558
Query: 771 LLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEF 830
L S + E L H T D LS + + +D ++ + S F
Sbjct: 1559 -LCSWVGQAERALAGHQGRTTQQD-------LSALQKNQSDLKDLQDDIQNRATS----F 1606
Query: 831 STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS 890
+T K ++ +E+ Q ++ P L T+L + L+QA E+
Sbjct: 1607 ATVVKDIEGFMEENQTKL---SPREL-------------------TALREKLHQAKEQYE 1644
Query: 891 SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI 950
A ++ + QK ++EE + T+ L +ETE + AK++
Sbjct: 1645 -----ALQEETRVAQK-------------ELEEAV---TSALQQETE-----KSKAAKEL 1678
Query: 951 KEMSEEMDKNKNLFSQAFPENGD---NRDVIEDTLGCLL--GRLSLLDSV--VNQ----- 998
E +++D + + G N +E G L G L D VNQ
Sbjct: 1679 AENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 1738
Query: 999 --RCHQMKERLQQILNFQNDLKVLFTS----LADNKYIILQKLANVFEQPVAEQIEAIQQ 1052
+C MK R Q++L+ Q + + S L + + + + + +Q + E E Q
Sbjct: 1739 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKE---Q 1795
Query: 1053 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLK 1112
L + +A + +++ D+LQ +Q+ + + + + + G + TL
Sbjct: 1796 YSTSLAQSEAELKQVQTLQDELQ---KFLQDHKEFESWLERSEKELENMHKGGSSPETLP 1852
Query: 1113 SQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLF 1172
S +R D++ GD + + S Q++LD + +G E I L
Sbjct: 1853 SLLKRQGSFSEDVISH-----KGDLRFVTISG---QKVLDMENSFKEGKEPSEI--GNLV 1902
Query: 1173 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV 1232
+ + A ++ T H+ + + G L +L + L ++
Sbjct: 1903 KDKLKDATERYTALHS-----------KCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 1951
Query: 1233 ESSIPSV--GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLL-ISISCSDL 1289
E+++ + V + L +++ + L+ L E+Q + ++ + ++ I +
Sbjct: 1952 EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPD 2011
Query: 1290 ESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQS 1349
+ + + LS+ +S L ++L+ I QS ++ LE Q
Sbjct: 2012 HRHVQETTDSILSHFQSLSYSLAERSSLLQK----------AIAQSQSVQESLESLLQSI 2061
Query: 1350 VTVPQELE----------MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTA 1399
V Q LE ++++ L ++ +++ Q KSS+ +T + R + +
Sbjct: 2062 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQ---KSSLEATREMVTRFMETADS 2118
Query: 1400 TLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDED 1459
T + L + V ++ QL + + ++ +++ + E++ K +
Sbjct: 2119 TTAAVLQG----------KLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQ 2168
Query: 1460 NIKNSIGYKA--------IHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRS 1511
++N A I + Q+ + +++ +Q +D + V ++SS
Sbjct: 2169 FMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC 2228
Query: 1512 DKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQ 1571
D + L K + LQ V E+ + E E+ V+ + W + E +
Sbjct: 2229 QHQDRVQNL---RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP 2285
Query: 1572 QHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLREL 1631
++ ++ + L D +K VE+I G +L +++M
Sbjct: 2286 TETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSL--------ENLIMEITAPD 2337
Query: 1632 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSY-----LMEARYSLS----RFRL 1682
Q G+ +L SV S +N Y L E + +S ++
Sbjct: 2338 SQ---------GKTGSILPSVGSSVGS-------VNGYHTCKDLTEIQCDMSDVNLKYEK 2381
Query: 1683 LTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK---E 1739
L G L Q + + N +++ K+ S+ ++ ++LK + T T T+K E
Sbjct: 2382 LGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAE 2441
Query: 1740 VNMRWNNLLEEIAEQLQSSKALL----------QLWQRYKDYSKQCASTVQQQED----R 1785
N + LE+ + ++Q K L Q + +K ++ S ++ + R
Sbjct: 2442 SNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVAR 2501
Query: 1786 TNELLKAATNK---DIADDEVATWIQDCNDLLKGLGTV----------KDSLFFLHELGE 1832
+L ++A++ A+ ++ W+ + ++ LG + K + F+ + E
Sbjct: 2502 QRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFE 2561
Query: 1833 QLKQQVD----------------ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 1876
+QQ + + + S +Q + S++Q L L + + + ++
Sbjct: 2562 ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIV 2621
Query: 1877 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 1936
+ + L+ L + + L Q S I + E +K Q+ + S + DL++
Sbjct: 2622 KSTQYQELLQDLSEKVRAVGQRLSVQ--------SAISTQPEAVKQQLEETSEIRSDLEQ 2673
Query: 1937 LN-----------ELGYRLP---LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH 1982
L+ EL + L D+ KR++ + + +R ++LQ+ L
Sbjct: 2674 LDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST 2733
Query: 1983 QTF---LEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSII 2039
Q F ++ TW++ Q++Q IS + L Q + +E FQ + I+
Sbjct: 2734 QQFQQMFDELRTWLDDK-QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIV 2792
Query: 2040 IDGQRLL-EQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
+G+ LL +++ +L L N W+ + ++ R+ + +++ Q+Y+ E
Sbjct: 2793 AEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVED 2852
Query: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158
L W +E MS L P+Q +L +V R+ S + + + +L++
Sbjct: 2853 LVPW-IEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRR--SLLEILNSAADILIN 2909
Query: 2159 ADSGAEAALQAELAEIQ-------EKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE 2211
+ E ++ E A I E+ ++ + LEE ++L + ++ EK + +
Sbjct: 2910 SSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKH 2969
Query: 2212 KLRTFKKKLSQSLPDHH-EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 2270
+L F SQ+ + + E+L A+Q + LE V + + TQ L++D D
Sbjct: 2970 QLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQV-DYLRNFTQ-GLVEDAPDG----SD 3023
Query: 2271 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 2330
S L + E+ Q+++ E+ +++ + +L F + +E+ L ++ ++
Sbjct: 3024 ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3083
Query: 2331 GDI---------------LIEEMIEKLKKDYQEEIA-----IAQEN-------KIQLQQM 2363
G I L I LK D + A + +E K +L+ +
Sbjct: 3084 GAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEAL 3143
Query: 2364 GERLAKASHESKA--SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 2421
++ K + KA ++E LG+V D ++ L K L + A ++ + +
Sbjct: 3144 NKQCGKLTERGKARQEQLELTLGRVEDFYRKL--------KGLNDATTAAEEAEALQWVV 3195
Query: 2422 RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 2481
T + I +LA ++ + +Q KL + L + + + S G DC
Sbjct: 3196 GTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ-SAG------------KDC 3242
Query: 2482 DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 2541
D + + + I + RW + +R +++E KF D WL
Sbjct: 3243 DVQGLEHDMEEI-------NARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD 3295
Query: 2542 SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 2601
+E A Y V K ++++ + QR + + ++++ + R+A+
Sbjct: 3296 TEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREK 3355
Query: 2602 LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 2661
+ + RW L + + ++L+ + ++F + I +L+ + +L N E
Sbjct: 3356 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415
Query: 2662 SE--CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY 2719
+Q +I + KA +++I + + Q + G+ L + P + ++ E++D L+
Sbjct: 3416 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQAR 3475
Query: 2720 CQEVFGRVERYHKKL------IRLPLPDDEHDLSDRELELED---SAALSDLHW---HDR 2767
E+ R R L RL +DE ++ + E+ED S + D H +
Sbjct: 3476 YSEIQDRCCRKAALLDQALSNARL-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ 3534
Query: 2768 SADSLLSPQPSSNLSLSLAQPLRSERS--GRDTPASVDSIPLEWDHDYDLSRDLESAMSR 2825
AD L + N ++ Q +++ ++ + T V I + D D+ S+
Sbjct: 3535 HADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSK 3594
Query: 2826 ALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTP 2885
AL + ++ Q F + L +R++ + L S Q E I
Sbjct: 3595 ALRTLEQARQLATKF--------QSTYEELTGWLREVEEELATSGGQSPTGEQI------ 3640
Query: 2886 TGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRW 2945
P+ K K + E +D+V + L E L + + + +++
Sbjct: 3641 --PQFQQRQKELKKEVMEHRLVLDTVNEVSRALLE----LVPWRAREGLDKLVSDANEQY 3694
Query: 2946 ELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 3005
+L+ + + +Q+ QQ+ ++ AW+ +T+ +L L + L D T +LQ
Sbjct: 3695 KLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ 3754
Query: 3006 IKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEW 3065
++K + + H+ ++ + S F ++ LQ++ + +++ + L E
Sbjct: 3755 VQKAFSID-IIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSER 3813
Query: 3066 RGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKH 3124
L+ A + F E L +E + I + S +D E L+ +++ Q++
Sbjct: 3814 YARLERAQVLVNQFWETYEELSPWIE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
Query: 3125 ELLESQLRVASLQDMSCQLL-VNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 3183
+ E + + L + QL +N E + +E EK N + +EV + L++
Sbjct: 3871 SIAEHKPHIDKLLKIGPQLKELNPEEGEMVE--EKYQKAENMYAQIKEEVRQRALALDEA 3928
Query: 3184 LDVSS 3188
+ S+
Sbjct: 3929 VSQST 3933
Score = 197 bits (501), Expect = 1e-49
Identities = 602/3489 (17%), Positives = 1331/3489 (38%), Gaps = 501/3489 (14%)
Query: 11 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 70
LE+ + K + + K E + A+ +S+L LEEY + ++K I+
Sbjct: 1018 LEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQR---VVKRIQSL 1074
Query: 71 KVLAHGTIAW-NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQ-YLTSVYCTEKMSQ 128
AW ++A ++ EQ + E+ +++ S+L+A++ K +L + +
Sbjct: 1075 ASSRTDRDAWQDNALRIAEQ----EHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT 1130
Query: 129 QVAELGRETEELRQM-------------IKIRLQNLQDAAKDMKKFEAELKKLQAALEQA 175
+EL E++ + + + ++++QDA +K +E +L + + L
Sbjct: 1131 LRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVL--- 1187
Query: 176 QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA 235
A L++ E +L+ LS + S L ++ ++ + E + P +
Sbjct: 1188 -ADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKV------VAEQMSRLTPERNL 1240
Query: 236 AL-RLQEEASRLQ---HTAIQQCNIMQAAVVQYEQ--------------YEQEMKHLQQL 277
L R QE+ S+LQ H I Q I Q+ + ++ + +E Q++
Sbjct: 1241 DLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEM 1300
Query: 278 IEGAHREIEDKPVATSNIQE---LQAQISRHEELAQKIKGYQEQIASL--NSKCKMLTMK 332
++ + ED V + + + L A+I R++ + + + +Q +++ + + +++T K
Sbjct: 1301 MKPG--QAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK 1358
Query: 333 AKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSP--------- 383
A + + + + ++ + E + + + ++V +T +
Sbjct: 1359 AFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEK 1418
Query: 384 VTEESGEE---------GTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 434
V EE +E G S ++ ++ S + + I Q LS E L T
Sbjct: 1419 VVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLS-EELTTK 1477
Query: 435 AAKIHPSTSASQEFY-EPGLEPSATAK------LGDLQRSWETL----KNVISEKQRTLY 483
++ + SQ F + G + S K L L +++ L N + + Q L
Sbjct: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537
Query: 484 EALERQ--QKYQDS----LQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILML 537
E++ QK Q++ L+ + + + E L+ GR+ + ++ Q ++ L
Sbjct: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAG--HQGRTTQQDLSALQKNQSDLKDL 1595
Query: 538 QDEINELQSSLA------EELVSES-CEADPAEQLALQSTLTVLAERMSTIRMKASGKRQ 590
QD+I +S A E + E+ + P E AL+ L E+ ++ + ++
Sbjct: 1596 QDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQK 1655
Query: 591 LLEEKLNDQLEEQRQE----QALQRYRCEADELDSWLLST-------------------- 626
LEE + L+++ ++ + L + + D L W+ S
Sbjct: 1656 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 1715
Query: 627 ---KATLDTA-----LSPPKEPMDMEAQLMDCQNM-LVEIEQKVVALSE-----LSVHNE 672
K LDT ++ E +D + ++M ++ L+ +Q + ++ L H
Sbjct: 1716 SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGH 1775
Query: 673 NLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQ 732
NL T +E + L KL LK A + +L T Q++ + +
Sbjct: 1776 NL-------TPEEQQMLQQKLGELKEQY-STSLAQSEAELKQVQTLQDELQKFLQ----D 1823
Query: 733 SPGVQEWLAQARTTWTQQRQ---------SSLQQQKELEQELAEQKSLLRSVASRGEEIL 783
+ WL ++ + S L++Q +++ K LR V G+++L
Sbjct: 1824 HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVL 1883
Query: 784 IQHSAAETSGDAGEKPDVLSQELGMEGEKSSA--------EDQMRMKWESLHQEFSTK-- 833
++ + + E +++ +L E+ +A + M HQ ++
Sbjct: 1884 DMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADS 1943
Query: 834 ------------QKLLQNVL-------------------EQEQEQVLYSRPNRLLSGVPL 862
+KLL + + E + QV + ++ +
Sbjct: 1944 LQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIME 2003
Query: 863 YKGDVPTQDKSAVTSLLDGLNQAFEEVS---SQSGGAKRQSIHLEQKLYDGVSATSTWLD 919
+G+ P D V D + F+ +S ++ +++I Q + + + + +
Sbjct: 2004 IEGE-PAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIG 2062
Query: 920 DVEERLF--VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDV 977
+VE+ L ++L + L L +DI ++ + + ++ F E D+
Sbjct: 2063 EVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTR-FMETADST-- 2119
Query: 978 IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLAN 1037
T L G+L+ + Q C Q +E+ ++ LK L ++ L
Sbjct: 2120 ---TAAVLQGKLAEVSQRFEQLCLQQQEK-------ESSLKKLLPQAEMFEH--LSGKLQ 2167
Query: 1038 VFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMI 1097
F + + + + Q + + F I EL L++E + L L+ + EL
Sbjct: 2168 QFMENKSRMLASGNQPDQDITHFFQQIQELN-----LEMED-QQENLDTLEHLVTEL--- 2218
Query: 1098 IGSRRSGLNQNLTLKSQYERAL---QDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKH 1154
S L L +R +D +L +T +E+ D +E ++L+
Sbjct: 2219 -----SSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK-DASSCQEQLDEFRKLVRTF 2272
Query: 1155 KEYFQGLESHMILTETLFRKIISFAVQKETQFHTELM---AQASAVLKRAHKRGVELEYI 1211
+++ + E + TET + + ++K+ + L+ A +++ + +G LE +
Sbjct: 2273 QKWLKETEGSIPPTET---SMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENL 2329
Query: 1212 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLY 1271
+ + D + S +PSVG + + Y H L E Q +
Sbjct: 2330 IMEITAPDSQGK--------TGSILPSVG-------SSVGSVNGY-HTCKDLTEIQCDM- 2372
Query: 1272 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 1331
SD+ + +LG + L+R+E + K E+ +
Sbjct: 2373 ---------------SDVNLKYEKLGGVLHERQESLQAILNRMEEVHK-------EANSV 2410
Query: 1332 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 1391
+ WL+S ++ L+ + +++ P + E V+ + F E++ S V LL
Sbjct: 2411 LQWLESKEEVLK--SMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLL 2468
Query: 1392 RL--KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISL 1449
+ + ++S+W A Q +L + + A S++ W+
Sbjct: 2469 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM- 2527
Query: 1450 MENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESK 1509
+++ + +G +I + + ++ K+ L ++Q + +
Sbjct: 2528 -------EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTG 2580
Query: 1510 RSD----KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 1565
D + ++L ++N+ W L + + ++ + ++Y+ +Q L
Sbjct: 2581 PGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV 2640
Query: 1566 EKRLKQQHRIGDQA-SVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSS 1622
+RL Q I Q +V+ L++ ++ ++ + EV++ + + L+++ ++ +
Sbjct: 2641 GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY-LKD 2699
Query: 1623 IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL 1682
+ L + L+ + L++ L + FD++ ++L + + ++
Sbjct: 2700 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCP 2759
Query: 1683 LTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE--TLTNTLKEV 1740
++ LE +Q Q+ + Q L + S + + LL PP E TL N L E+
Sbjct: 2760 ISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV-PPGEEKRTLQNQLVEL 2818
Query: 1741 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 1800
W L ++ A++ K +Q Q+Y+ + + ++ + + +EL +
Sbjct: 2819 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLES 2878
Query: 1801 D-----EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQ 1855
+ ++ LL+ L + D L E E I+ ++ ++Q
Sbjct: 2879 SLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED-----------GIRDEKAGINQ 2927
Query: 1856 HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQE 1915
++ A+ + L + SL+ F +S + +E + A+ L+ D S S +
Sbjct: 2928 NMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSN--K 2985
Query: 1916 RMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL 1975
+E+L+ Q ++ P +D L +N + + ++ L
Sbjct: 2986 NLEKLRAQQEVLQALEPQVDYL-----------------RNFTQGLVEDAPDGSDASQLL 3028
Query: 1976 QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQ--AEMFSRQQ 2033
+ Q FLE + V E KL E G + R E+F A++
Sbjct: 3029 HQAEVAQQEFLEVKQRVNSGCVMMENKL--EGIGQFHC-----RVREMFSQLADLDDELD 3081
Query: 2034 ILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLS---NQWQGVIRRAQQRRGIID------- 2083
+ +I D L Q Q++D F K+ +L + R + G +D
Sbjct: 3082 GMGAIGRDTDSL--QSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRE 3139
Query: 2084 --------SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE 2135
++ + + R+ +L VE Y + GL ++A L V +
Sbjct: 3140 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3199
Query: 2136 KVFLRQQGSYILTVEA---------------GKQLLLSADSGAEA-ALQAELAEIQEKWK 2179
++ +Q + + + G+ L+ SA + L+ ++ EI +W
Sbjct: 3200 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3259
Query: 2180 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD--HHEELHAEQMR 2237
+ + ++ ++ +L L K + + L L ++ ++ P ++ + A+
Sbjct: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3319
Query: 2238 CKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQ 2297
K L+ + + L ++ D + ++E L+ +W EL + + R++
Sbjct: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
Query: 2298 QIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAI 2352
Q+ + L F E + + ++L+ E K++ + + I++ I + K +E+I
Sbjct: 3380 QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR-HKALEEDIEN 3438
Query: 2353 AQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ 2412
+ Q ++G+ L+ + ++ + K+ + R+ + D + L + L +
Sbjct: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 3498
Query: 2413 QLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLN 2472
++ + WLA +E +L+ V D + + R+ + L +I V +
Sbjct: 3499 LFGEDEVEVLNWLAEVEDKLSSVFVKDF-KQDVLHRQHADHLALNEEIVNRKKNVDQAIK 3557
Query: 2473 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 2532
+ LL T E IQ+ + R+ +I S + +E+ +L KF Y
Sbjct: 3558 NGQALLKQ----TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTY 3613
Query: 2533 SRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR 2592
WL+ E A + ++ + +++V E L+ +N+ R L
Sbjct: 3614 EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLE 3673
Query: 2593 ENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 2652
+ L ++V + N+++ + + + + I + +++E A D+ L W+ E
Sbjct: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETK 3733
Query: 2653 LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 2712
+L ++L ++EQ + ++K+ +D ++
Sbjct: 3734 RKL------------------------MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDS 3769
Query: 2713 LDELRRYCQEVFGRVERYHKKLIRLPLPD--DEHDL-----SDRELELEDSAALSDLHWH 2765
+DEL + E+FG K +++ +++ S+R LE + L + W
Sbjct: 3770 MDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWE 3829
Query: 2766 DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR 2825
LSP +L P +PA +D L + R L +++
Sbjct: 3830 TYEE---LSPWIEETRALIAQLP---------SPA-IDHEQLRQQQEE--MRQLRESIAE 3874
Query: 2826 ALPSED--------------EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRF 2871
P D EEG+ ++ Y + ++ ++ ++RQ ALD++
Sbjct: 3875 HKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKA----ENMYAQIKEEVRQRALALDEAVS 3930
Query: 2872 QIQQ-------------TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE--- 2915
Q Q T + S+ P + + + + S+ +++L+
Sbjct: 3931 QSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSF 3990
Query: 2916 HKLKEEEESLPGFVNLHSTETQTAGVIDR-------WELLQAQALSKELRMKQNLQKWQQ 2968
LK E L G + + D+ WE ++A+A +E++ L+ ++
Sbjct: 3991 EALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEK 4050
Query: 2969 FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINL 3028
F D+ ++ + DT++ + L+ + I I+ Q++ + +++ D + I +
Sbjct: 4051 FWYDMAALLTTIKDTQDIVHDLESPGIDPSI--IKQQVEAAETIKEETDGLHEELEFIRI 4108
Query: 3029 CSPEFTQA-DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 3087
+ A E +++ + +MN W+ + +E L+DA+ + + +
Sbjct: 4109 LGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMF 4168
Query: 3088 LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 3147
L+N + + P+ ++L+ ++D ++ + K E+ + Q+ + L +L A
Sbjct: 4169 DWLDNTVIKLCTMPPVGTDLNT--VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA 4226
Query: 3148 -EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE- 3201
+ TD +E + + + + L ++++ +LE L + ++L SW + E
Sbjct: 4227 TDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEE 4286
Query: 3202 -LDTSGSVS 3209
LD +S
Sbjct: 4287 LLDAQRPIS 4295
Score = 117 bits (293), Expect = 2e-25
Identities = 399/2277 (17%), Positives = 882/2277 (38%), Gaps = 342/2277 (15%)
Query: 1111 LKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLL------DKH----KEYFQG 1160
L++ YE LQD D + ++ + + K Q L+ DK K Y
Sbjct: 993 LQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISE 1052
Query: 1161 LESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDE 1220
L++ + E ++++ +Q T+ A L+ A + H E
Sbjct: 1053 LKNIRLRLEEYEQRVVK-RIQSLASSRTDRDAWQDNALRIAEQE------------HTQE 1099
Query: 1221 DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL 1280
D Q+L L+ V S + + L+S LN K+ V
Sbjct: 1100 DLQQLRSDLDAVSMKCDSFLHQSPSSSSV-------PTLRSELNLLVEKMDHVYGLSTVY 1152
Query: 1281 LISISCSDLESQLNQLGECWLSNTN-KMSKELHRLETILKHWTRYQSESADLIHWLQSAK 1339
L + D+ + Q E + K+S+E E +L + ++ + L HWL K
Sbjct: 1153 LNKLKTVDVIVRSIQDAELLVKGYEIKLSQE----EVVLADLSALEAHWSTLRHWLSDVK 1208
Query: 1340 DRLEFWT--------------QQSVTVPQ---ELEMVRDHLNAFLEFSKEVDAQSSLKSS 1382
D+ ++ Q S P+ +LE ++ + E V AQ ++ S
Sbjct: 1209 DKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQS 1268
Query: 1383 VLSTGNQLLR---------LKKVDTATLRSE------------LSRIDSQWTDLLTNIPA 1421
L + ++L +K ++ T + E LS SQ T L I
Sbjct: 1269 ELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIER 1328
Query: 1422 VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFK 1481
Q KL Q Q S + I KD + + YKA E QK G +
Sbjct: 1329 NQTKLDQCQK---------------FSQQYSTIVKDYE--LQLMTYKAFVESQQKSPGKR 1371
Query: 1482 IDI--NCKQLTVDFVN-----QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV 1534
+ + +T +F++ +++ +++Q V+ ++ L + + ++++
Sbjct: 1372 RRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKY-------ISDALRRLEEEEKVVEEEK 1424
Query: 1535 TEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDL 1594
E ++ ++ LL S N Q T ET+E ++ A+ + Q L +
Sbjct: 1425 QEHVEKVKELLGWVSTLARNTQGKATSSETKES-----------TDIEKAILEQQVLSEE 1473
Query: 1595 IKAKEKEVEK--------IEQNGLALIQNKKEDVSS-----------IVMSTLRELGQTW 1635
+ K+++V + + ++G L + +K+ +S + + +L Q
Sbjct: 1474 LTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ 1533
Query: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS--RFRLLTGSLEAVQVQ 1693
+ L H Q K++ Q ++ + + S++ +A +L+ + R L A+Q
Sbjct: 1534 SQLAHQTEQ-----KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN 1588
Query: 1694 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 1753
+L++LQDD++ + S ++E ++ L+E L + E
Sbjct: 1589 QSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK-------LHQAKE 1641
Query: 1754 QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDL 1813
Q ++ + ++ Q K+ + S +QQ+ +++ + A NK D + D
Sbjct: 1642 QYEALQEETRVAQ--KELEEAVTSALQQETEKSKAAKELAENKKKIDALL--------DW 1691
Query: 1814 LKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQA 1873
+ +G+ L EQL A + ++Q L++ + Q
Sbjct: 1692 VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE 1751
Query: 1874 GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 1933
+ + F + ++ +A++ + L ++ +Q+++ ELK Q
Sbjct: 1752 LLSQQQNFILATQSAQAFLDQHGHNLTPEEQQ------MLQQKLGELKEQY--------- 1796
Query: 1934 LDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWM 1993
L ++ E+K++Q L +LQ FL H+ F E+W+
Sbjct: 1797 -------STSLAQSEAELKQVQTLQ--------------DELQKFLQDHKEF----ESWL 1831
Query: 1994 EFLVQTEQKLAVEISGNYQ-----HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ 2048
E ++E++L G LL++Q + F ++ S + L + I GQ++L+
Sbjct: 1832 E---RSEKELENMHKGGSSPETLPSLLKRQGS---FSEDVISHKGDLRFVTISGQKVLDM 1885
Query: 2049 GQV-----DDRDEFNL---KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
+ + NL KL + ++ + + + ++ + Q+ +++ A+ L+
Sbjct: 1886 ENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQ 1945
Query: 2101 KWL----VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL 2156
W+ V L + S P LQ+ L Q +E++ Q L A +
Sbjct: 1946 AWMQACEANVEKLLSDTVASDPGVLQEQ--LATTKQLQEELAEHQVPVEKLQKVARDIME 2003
Query: 2157 LSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT 2215
+ + + +Q I ++S S L E+ L + + ++ + L+ +
Sbjct: 2004 IEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2063
Query: 2216 FK-----KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 2270
+ K++S +E A M+ K+ + L ++ ++ ++ D
Sbjct: 2064 VEQNLEGKQVSSLSSGVIQEALATNMKLKQ------DIARQKSSLEATREMVTRFMETAD 2117
Query: 2271 ---ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV 2327
++L ++ + +++E+LC Q + + + L + +F + +L +++ + +S++
Sbjct: 2118 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM-ENKSRM 2176
Query: 2328 SQNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGK 2385
+G+ +++ ++ + E+ QEN L+ + L+ + + ++
Sbjct: 2177 LASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2236
Query: 2386 VNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEE 2445
+ + L + R K + + K + + + WL E + P S +++E
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI--PPTETSMSAKE 2294
Query: 2446 IQRKLNEQQELQRD-------IEKHSTGVASVLNLC-EVLLHDCDACA------------ 2485
+++++ + L D +E+ + S+ NL E+ D
Sbjct: 2295 LEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVG 2354
Query: 2486 ------TDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 2539
T + IQ +++ ++ + + ER+ ++ ++ + + WL
Sbjct: 2355 SVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWL 2414
Query: 2540 KSSERT--AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-ARENRT 2596
+S E + SS K + + +AF ++ + +++ + + L +
Sbjct: 2415 ESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNS 2474
Query: 2597 DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL- 2655
A + K++ E N RW+ + + R+L+ F+ A + WL E +L +
Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 2534
Query: 2656 --------TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA 2707
N+ + + VQ +K+ +A +Q+ H ++ + AQG L +
Sbjct: 2535 VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ----HEQLNEA-AQGILTGPGDVSLSTS 2589
Query: 2708 IIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDR 2767
+++EL + + E+ ++ ++ + + ++ ++L + A L
Sbjct: 2590 QVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL----- 2644
Query: 2768 SADSLLSPQPSS-NLSLSLAQPLRSE-----RSGRDTPASVDSIPLEWDHDY---DLSRD 2818
S S +S QP + L +RS+ ++ D + + Y +L +
Sbjct: 2645 SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR 2704
Query: 2819 LESAMSRALPSED-EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTE 2877
LE+ ALP + E+ D+ L+ A+ + + ++R LDD Q QQ +
Sbjct: 2705 LETV---ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW---LDDK--QSQQAK 2756
Query: 2878 NI-IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 2936
N I +K + + K L + S S + + L S+P + +
Sbjct: 2757 NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLL---SVPPGEEKRTLQN 2813
Query: 2937 QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 2996
Q + + WE L + ++ R+K +QK Q++ + + W+ D + ++ +L+ ++
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELR---VT 2870
Query: 2997 TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD 3056
D +E + + K + V+ R++++ +N + + + ++D + +N D
Sbjct: 2871 LDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMD 2930
Query: 3057 RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHH 3116
V L+ G L++ + + F E + + ++ K+++ D+ L ++ + +
Sbjct: 2931 AVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLEIFDA-LGSQACSNKN 2986
Query: 3117 KQLMQIKHELLES-QLRVASLQDMSCQLLVNA-EGTDCLEAKEKVHVIGNRLKLLLKEVS 3174
+ ++ + E+L++ + +V L++ + L+ +A +G+D + + V + + V+
Sbjct: 2987 LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVN 3046
Query: 3175 RHIKELEKLL-----------DVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQ 3220
+E L ++ S DL DELD G++ GR T + Q
Sbjct: 3047 SGCVMMENKLEGIGQFHCRVREMFSQLADLD-----DELDGMGAI----GRDTDSLQ 3094
Score = 108 bits (269), Expect = 1e-22
Identities = 253/1468 (17%), Positives = 564/1468 (38%), Gaps = 208/1468 (14%)
Query: 21 LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIE--KAKVLAHGTI 78
L K + E ++ R+ +++ A ++Y + + L W+ K K++A G I
Sbjct: 3683 LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI 3742
Query: 79 AWNSASQLREQYILHQTLLEESKEID--SELEAMTEKLQYLTSVY--CTEK----MSQQV 130
+L + Q ++++ ID ++M E + + ++ C E+ + ++
Sbjct: 3743 ------RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 3796
Query: 131 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQAT---LTSPEVGRL 187
L ++ E + + R L+ A + +F ++L +E+ +A L SP +
Sbjct: 3797 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 3856
Query: 188 SLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQ 247
L++Q + L + KP + + L+ + + + + ++++
Sbjct: 3857 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM-VEEKYQKAENMYAQIK 3915
Query: 248 HTAIQQCNIMQAAVVQYEQ---YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISR 304
Q+ + AV Q Q + +++ + + +E + P+ + + +++ IS
Sbjct: 3916 EEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISD 3975
Query: 305 HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGT----EDLDGELL 360
++ +++ Q +L + + L +++ A L E++ + ED+
Sbjct: 3976 NKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4035
Query: 361 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 420
V+ + + + + +T + ++ SP ++ I
Sbjct: 4036 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP--------------GIDPSI 4081
Query: 421 AYYQALSAERLQTDAAKIHPSTS-----ASQEFYEPGL--EPSATAKLGDLQRSWETLKN 473
Q +AE ++ + +H + + G +P + ++ +WE L
Sbjct: 4082 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNK 4141
Query: 474 VISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG---RSPESQMAEHQAL 530
E+ L +A++ +YQD+LQ++ ++ +KL P G + + Q+ E +
Sbjct: 4142 TWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF 4201
Query: 531 MDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQ 590
E+ Q E+ +L E ++ ++ D ++ ++ LT L + K + ++
Sbjct: 4202 KVEVYQQQIEMEKLNHQ-GELMLKKA--TDETDRDIIREPLTELKHLWENLGEKIAHRQH 4258
Query: 591 LLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD- 649
LE L AL +++ +EL SWL T+ LD +P +E +L
Sbjct: 4259 KLEGAL----------LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4308
Query: 650 --CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRAL 707
+N ++ + V +++ N LLE A D+A L +L + + +
Sbjct: 4309 HVLKNDVLAHQATVETVNKAG----NELLESSA--GDDASSLRSRLEAMNQCWESVLQKT 4362
Query: 708 HDKQLNMQGTAQEKE--ESDVDLTATQSPGVQEWLAQARTT--WTQQRQSSLQQQKELEQ 763
+++ +Q T Q+ + S+++ + ++ L+ ++ T + + L EL
Sbjct: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4422
Query: 764 ELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE-----LGMEGEKSSAEDQ 818
+L ++ + +G +L+ + + + +L Q+ ME KS E+
Sbjct: 4423 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4482
Query: 819 MRM--KWESLHQEF--------------STKQKLLQNVLEQEQEQVLYSRP-----NRLL 857
+ + ++++ QEF S +L VL Q +E +++ ++++
Sbjct: 4483 LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 4542
Query: 858 ----SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSGGAKRQSIHLEQKLYDG 910
+G L K QD + +LL + +E+V S + G + + ++ ++
Sbjct: 4543 ELDQTGNQL-KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 4601
Query: 911 VSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKEMSEEMD---------K 959
WL+D E L + P++ + L + K + D K
Sbjct: 4602 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALK 4661
Query: 960 NKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKV 1019
K L PE+ D LG + V + + + +L++ L F
Sbjct: 4662 EKTL----LPEDSQKLD-------NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMD 4710
Query: 1020 LFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFD------AGIIELKRRGDK 1073
+L D Y + +LA +QPV ++ + D K F G +++ +R +
Sbjct: 4711 ALQALVDWLYKVEPQLAE--DQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGR 4768
Query: 1074 LQVEQPS------MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLE 1127
+E +L +L +D + + S++S L Q L + + L + L
Sbjct: 4769 ELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLS 4828
Query: 1128 TGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI--------------------- 1166
++ + + + E +Q L+D HKE+ + +E +
Sbjct: 4829 EAEQTLR-FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI 4887
Query: 1167 --------LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSH- 1217
+ F +++++A Q + + T L S ++ A L +I W+
Sbjct: 4888 TTIKHWITIIRARFEEVLTWAKQHQQRLETAL----SELVANAELLEELLAWI--QWAET 4941
Query: 1218 --LDEDQQELSRQLEVVESSIPSVGLVEENEDRL---IDRITLYQHLKSSLNEYQPKLYQ 1272
+ DQ+ + + ++ V++ I E R +DR+T K+ + P + +
Sbjct: 4942 TLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK 5001
Query: 1273 VLDDGKRLLIS--------ISCSDLES-QLNQLGECW-------LSNTNKMSKELHRLET 1316
G++ L +S S+ ++ ++NQL W L K++ L RLE
Sbjct: 5002 SRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE 5061
Query: 1317 ILKHWTRYQSE--SADLIHWLQSAKDRL 1342
LK + + + + W+ K R+
Sbjct: 5062 -LKEFANFDFDVWRKKYMRWMNHKKSRV 5088
Score = 52.4 bits (124), Expect = 7e-06
Identities = 116/685 (16%), Positives = 267/685 (38%), Gaps = 61/685 (8%)
Query: 3 LDAAVQKFLEQN-GQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
++ A + LE + G L ++ + + + +++ E R +L + ++ +E
Sbjct: 4325 VNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE 4384
Query: 62 -LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLT-- 118
+L+ L+ REQ H L + K + + +K + +
Sbjct: 4385 DFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS 4444
Query: 119 --SVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ 176
K Q VA L ++ + ++ R L++A +F+ L++ L A+
Sbjct: 4445 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 4504
Query: 177 ATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKVQAVQLCQSALRIP-----EDVVASL 230
+L L L LS +H + E + Q ++L Q+ ++ +DVV
Sbjct: 4505 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL-- 4562
Query: 231 PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPV 290
+ + + +Q ++ +I++ + A + +Q+ + K L +E A ++ +
Sbjct: 4563 -IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 4621
Query: 291 ATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE 350
+++ +++ Q+S+H+E + + G Q + T++ A T+ L E
Sbjct: 4622 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDT--------TIRTGRALKEKTL-----LPE 4668
Query: 351 GTEDLDGELLPTPSAHPSVVMMTAGRCH-----TLLSPVTEESGEEGTNSEISSPPACRS 405
++ LD L +V + R H L S ++ + + P
Sbjct: 4669 DSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAE 4728
Query: 406 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAK--LGD 463
PV + D + ++ + + L + + +E E + + K L +
Sbjct: 4729 DQPV-HGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 4787
Query: 464 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKL---SESPEPGRSP 520
L W+T+ + KQ L +AL++ + ++D++ + + E L P+ +
Sbjct: 4788 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEAL 4847
Query: 521 ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMST 580
+S + H+ M ++ + ++N + E++ C D ++ +T++ R
Sbjct: 4848 QSLIDTHKEFMKKVEEKRVDVN--SAVAMGEVILAVCHPDCI--TTIKHWITIIRARFEE 4903
Query: 581 IRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP 640
+ A +Q LE L++ + +EL +W+ + TL + +EP
Sbjct: 4904 VLTWAKQHQQRLETALSELVANAEL----------LEELLAWIQWAETTL---IQRDQEP 4950
Query: 641 MD-----MEAQLMDCQNMLVEIEQK 660
+ ++A + + Q + E+ +K
Sbjct: 4951 IPQNIDRVKALIAEHQTFMEEMTRK 4975
Score = 35.4 bits (80), Expect = 0.95
Identities = 58/267 (21%), Positives = 103/267 (38%), Gaps = 25/267 (9%)
Query: 2903 ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 2962
E SS+ + E K+ + N H++ +T G ++ + S +R Q+
Sbjct: 631 ELGSSVKEARLYEGKMSQ---------NFHTSYAETLGKLETQYCKLKETSSFRMRHLQS 681
Query: 2963 LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-ELQKAVDHRKA 3021
L K F S + WL + EEE + +++I +L EL++ D ++
Sbjct: 682 LHK---FVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRS 738
Query: 3022 IILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHE 3081
+ + L S E A K++ + Q +W + L E A Q F
Sbjct: 739 LQDTAELLSLENHPA--KQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQ---FFS 793
Query: 3082 MSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 3141
+ L L N+ D N L+D + M K +L++S+ VASL S
Sbjct: 794 DARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSK 853
Query: 3142 QLLVNAEGTDCLEAKEKVHVIGNRLKL 3168
++ L+ + HV+ N + +
Sbjct: 854 TIVQ-------LKPRSPDHVLKNTISV 873
Score = 34.3 bits (77), Expect = 2.1
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 12/227 (5%)
Query: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
+L ++ L EE +L+R E D+ ++ELQ++ + + +V+ + + L
Sbjct: 585 NLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARL--- 641
Query: 3032 EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 3091
+ K S++ ++ G+ + L+E L F + L+ L
Sbjct: 642 ----YEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLN 697
Query: 3092 NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL-LVNAEGT 3150
+ + D+N + +++ +L EL E Q SLQD + L L N
Sbjct: 698 EKEEEELAYDWSDNNSNISAKRNYFSELTM---ELEEKQDVFRSLQDTAELLSLENHPAK 754
Query: 3151 DCLEA-KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSW 3196
+EA V +K L V +H+KE S ++L S+
Sbjct: 755 QTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESF 801
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 264 bits (675), Expect = 1e-69
Identities = 605/3391 (17%), Positives = 1312/3391 (38%), Gaps = 380/3391 (11%)
Query: 32 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 91
H+Q I Q + S + E +E+ +L+ +V GT N Q ++
Sbjct: 1743 HKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNLLETDVDGQV---GTTQENLNQQYQKVKA 1798
Query: 92 LHQTLLEESKEI---DSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRL 148
H+ ++ + + + + + EK S EK+ + + EL E + ++
Sbjct: 1799 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1858
Query: 149 QNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGR-------LSLKEQLSHRQHLLS 201
+ ++++KF+A+ + + L+Q++ L + E G LK Q S + ++S
Sbjct: 1859 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1918
Query: 202 EMESLKPKV----QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIM 257
L+ + ++ +S + V + R + A+ + +CN++
Sbjct: 1919 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1978
Query: 258 ----QAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRH--EELAQK 311
+ V +Y+ YE L + +Q +A S+H E +A
Sbjct: 1979 GNNLKDLVDKYQHYEDASCGL-----------------LAGLQACEATASKHLSEPIAVD 2021
Query: 312 IKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVM 371
K Q Q+ + ++ + ++ + V +++ AE D G LLP + +
Sbjct: 2022 PKNLQRQLEETKA------LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD 2075
Query: 372 MTAGRCHTLLSPVTEE------------SGEEGT--------NSEISSPPACRSPSPVAN 411
GR L V E S ++G N E S + P
Sbjct: 2076 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTA 2135
Query: 412 TDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETL 471
++++I Q ++ + +A ++ E +P S AK+ DL +
Sbjct: 2136 LQDIISKNIMLEQDIAGRQSSINA--MNEKVKKFMETTDPSTASSLQAKMKDLSARFSEA 2193
Query: 472 KNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALM 531
+ E + E + + +++ + + T +E L+E PG+ Q
Sbjct: 2194 SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQEST 2253
Query: 532 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMS-TIRMKASGKR- 589
E L + + E+ SL +E+ S +D A L + L+ + M TI+ K
Sbjct: 2254 SEFLEHKKHL-EVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2312
Query: 590 --------QLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPM 641
Q+L + L ++E ++ + + A++L L TK + E
Sbjct: 2313 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2372
Query: 642 DMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK-LRRLKGSL 700
+ + N++ + A++ +V + +L G+ + E A K L +K +
Sbjct: 2373 KVNNSGISLCNLISAVTTPAKAIA--AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDM 2430
Query: 701 LELQRALHDKQLNMQGTAQEKEE--SDVDLTATQSPGVQEWLAQARTTWTQQRQS----- 753
++ D L ++ E S + +S + +WL + T T+ +Q+
Sbjct: 2431 TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2490
Query: 754 ------SLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP-------- 799
++Q K E EL + + ++ + + E+L E + D E P
Sbjct: 2491 TEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL------EENPDTPEAPRWKQMLTE 2544
Query: 800 -DVLSQELGM-------EGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVL---------- 841
D QEL + E+SS E+ +++ +++L+ +VL
Sbjct: 2545 IDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNML 2604
Query: 842 --EQEQEQVL----------YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV 889
+++Q Q+L Y + G+ G+ P+ + V L + Q ++ +
Sbjct: 2605 NTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSL-RGIVKEQLAAVTQKWDSL 2663
Query: 890 SSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEIL 946
+ Q Q+I + + + S L D++ +L + A+ T NQ++
Sbjct: 2664 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV---STHPDAMNQQLE 2720
Query: 947 AKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL--SLLDSV--VNQRCHQ 1002
+ + +K + +QA E+ V E+ L L R +L S V Q+
Sbjct: 2721 TAQKMKQEIQQEKKQIKVAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAEN 2779
Query: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062
+ LQ + + + ++ +K P++ +++ ++ K+F
Sbjct: 2780 HVQHLQSACASSHQFQQMSRDF--QAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2837
Query: 1063 GIIELKRRGDKLQVEQPSMQ-------------ELSKLQDMYDELMMIIGSRRSGLNQNL 1109
+ +K E ++ +L+ ++ +D + R + L ++L
Sbjct: 2838 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2897
Query: 1110 TLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE--IQQLLDKHKEYFQGLESHMIL 1167
+Y+ ++ L ++ Q + + + ++ E I +L KE Q +L
Sbjct: 2898 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELL 2957
Query: 1168 TETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL 1225
T + + KE T + L+ + V ++ H + LE + + + E +E
Sbjct: 2958 NNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3017
Query: 1226 SRQLEVVESSIP---SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
RQL+ + + S+G + L T+ Q + SL + ++ + L++
Sbjct: 3018 KRQLQCAKEQLDIHDSLGSQAYSNKYL----TMLQTQQKSLQALKHQVDLAKRLAQDLVV 3073
Query: 1283 SIS----CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSA 1338
S SD+ Q+ + + + + ++ ++ LET L+ +Q+ ++
Sbjct: 3074 EASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3133
Query: 1339 KDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-- 1396
D L+ V ++ E ++ F K+++A + + T +L ++
Sbjct: 3134 DDELD----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3189
Query: 1397 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQK 1456
D ++ +L + Q LL A +E++ + +L + S++ + L++ +
Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT-IKRLEEFY--SKLKEFSILLQKAEEH 3246
Query: 1457 DEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESKRSD 1512
+E + + I++ L +K F+ + + KQ V+++ Q ++Q +++ ++ +
Sbjct: 3247 EESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLE 3306
Query: 1513 KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKRLKQ 1571
L +N W+ L V ++ L+ L +++ ++ L +W +T+E Q
Sbjct: 3307 -----HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ 3361
Query: 1572 QHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLREL 1631
+ + V+ +++ + L+ L+ ++ VE I++ G + + ++ L L
Sbjct: 3362 KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLL 3421
Query: 1632 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 1691
W L + L+ + + +N +L L + ++
Sbjct: 3422 DSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLE 3481
Query: 1692 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751
Q+ + L+DD+ + L + SI Q LK + + + + + W EI
Sbjct: 3482 EQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQVW---YIEI 3537
Query: 1752 AEQLQSSKALLQL--------------WQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 1797
E+ S LLQ + + S + Q+ T L K +
Sbjct: 3538 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3597
Query: 1798 IADDEVATWIQDCND-LLKGLGTVK----DSLFFLHELGEQLKQQ------VDASAASAI 1846
+ +++ Q+ + LL GL +K D + + + E +K + + A +
Sbjct: 3598 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3657
Query: 1847 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 1906
+ L L++ L + + LC ++ +L YET ++L+G++ S
Sbjct: 3658 EQ-ALQLARRLHSTHEELCTWLDKVEVELLSYET----------------QVLKGEEASQ 3700
Query: 1907 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL----PLNDKE--IKRMQNLNRH 1960
+ Q R +ELK + ++ LD LNE+ L P +E K + N
Sbjct: 3701 A------QMRPKELKKEAKNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAEDNER 3751
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQ 2018
+ L+S T++ ++ + +L+ Q F + + + ++ +TE+KL +I Q
Sbjct: 3752 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3811
Query: 2019 RAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
+ + F E+ + I+ ++ G +++ +++ KL + + + + +R
Sbjct: 3812 QVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3871
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV- 2137
++ ++ E E+L WL E + + +P P + TL + + ++
Sbjct: 3872 YLQLERAQSLVNQFWETYEELWPWLTETQSI----ISQLPAPALEYETLRQQQEEHRQLR 3927
Query: 2138 -FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM---RLEEQKKKLA 2193
+ + +I + LL G E IQEK+ +A +++E KK A
Sbjct: 3928 ELIAEHKPHIDKMNKTGPQLLELSPG-------EGFSIQEKYVAADTLYSQIKEDVKKRA 3980
Query: 2194 FLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLT 2253
L + D ++++ +++ + L + AE + KE + + + D+
Sbjct: 3981 VALDEAISQSTQFHDKIDQILESLERIVERLRQP-PSISAEVEKIKEQISENKNVSVDME 4039
Query: 2254 QLSLLKDTLS-------AYISADDISI----LNERVELLQRQWEELCHQLSLRRQQIGER 2302
+L L +TL A D I + ++++ + WE + + R ++ +
Sbjct: 4040 KLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4099
Query: 2303 LNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKD----YQEEIAIAQENKI 2358
+ F + L + + + D I+ + K +++ +EEI QE
Sbjct: 4100 MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELD 4159
Query: 2359 QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ +G L A E ++ + ++N W L R+ KL+E + A Q +
Sbjct: 4160 IVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4219
Query: 2419 SSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
++ W+ +LA PI D E +++++ E ++ + + + + + + E+
Sbjct: 4220 QAVFDWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL 4276
Query: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
LL +++ ++Q L W ++ + R+ K+E +F
Sbjct: 4277 LLKKV---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4333
Query: 2537 DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT 2596
WL +E + G + EL K Q V + +E +NK L +
Sbjct: 4334 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4393
Query: 2597 DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 2656
+ A +L+ + NQRW N+ ++ ++L + Q + F + + WLT+ + L
Sbjct: 4394 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4453
Query: 2657 NIEHFSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIEEEL 2713
+ AK +QL + + K E ++ +G+Q++ + I++++
Sbjct: 4454 ASKPLGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDI 4512
Query: 2714 DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL- 2772
+ L+ + V E L++R+ +LE++ L+ + +H+ D +
Sbjct: 4513 NNLKEKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQDFIN 4552
Query: 2773 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 2832
Q L+++ L +D++ + D + ++ S + + D+
Sbjct: 4553 WLTQAEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQIIEL-DK 4600
Query: 2833 EGQDDKDFYLRGAVGLSGD-----HSALESQIRQL---GKALDDSRFQIQQ--------T 2876
G K F + V L + S E +++L G++LDD+R + +Q
Sbjct: 4601 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4660
Query: 2877 ENIIRSKTPTGPELDTS------------YKGYMKLLGECSSSIDSVKRLEHKLKEEEES 2924
E + S+ EL+ + +K + K LG S D+ R LKE+
Sbjct: 4661 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4720
Query: 2925 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
+ L + + + D+W+ + +++ ++ ++++ L QF L ++ WL E
Sbjct: 4721 ADDNLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4777
Query: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 3044
+L + Q + DI + I K QK + R + + ++ + E + +S +
Sbjct: 4778 PQLAEDQPVH--GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4835
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVP 3102
+ ++ +++ RW+ VC+L + L+ AL Q + FH + H LL L ++ R + ++P
Sbjct: 4836 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4895
Query: 3103 IDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
D + L D HK+ M+ +L E + + M +L K + +I
Sbjct: 4896 DDEDA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4951
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 3193
R + +L +H + L L ++Q+L
Sbjct: 4952 RARFEEVLAWAKQHQQRLASALAGLIAKQEL 4982
Score = 253 bits (647), Expect = 2e-66
Identities = 639/3471 (18%), Positives = 1341/3471 (38%), Gaps = 495/3471 (14%)
Query: 23 KKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNS 82
+K +L E Q Q +NRL L L+ Y + + WI++ + I N
Sbjct: 1291 EKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET-TQRKIQENQ 1349
Query: 83 -------ASQLREQYIL------HQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ 129
A+QL +Q +L Q+ ++E ++ + A + + T Y SQQ
Sbjct: 1350 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1409
Query: 130 VAELGR------------ETEELR----QMIKIRLQNLQDAAKDMKKFEAE--------- 164
+ + R E +LR ++ + Q ++ A +K+ E E
Sbjct: 1410 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1469
Query: 165 -----LKKLQAALEQAQATLTSPE-VGRLSLKEQLSHRQHLLSEMESLKPKVQAVQL--- 215
K+LQ + TL E G+ +Q + + ++ E L +Q +QL
Sbjct: 1470 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1529
Query: 216 -----------------------------CQSALRIPE-----DVVASLPLCHAALRLQE 241
+S ++ E DV + A R QE
Sbjct: 1530 KHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI--VAERQQE 1587
Query: 242 EASRLQH------------TAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKP 289
+LQ Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + +
Sbjct: 1588 YKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVV 1647
Query: 290 VATSNIQELQAQISRHEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGL 348
T N + E+L+Q+ K EQ + KC+ L +KA+ + L +
Sbjct: 1648 KNTENFLK-----ENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1702
Query: 349 AEGTEDLDGELLPTPSAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGT-NSE 396
E TE + S S V + R T V E++G +EG S
Sbjct: 1703 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSA 1762
Query: 397 ISSPPACRS-------PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQE 447
I V T ++NQ YQ + A E++ + + +T ++Q
Sbjct: 1763 IGEEDEVNGNLLETDVDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQV 1819
Query: 448 FYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAI 506
E + + + LQ++ + LK YE AL +K S+ ++E
Sbjct: 1820 LLEKQGQYLSPEEKEKLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKF 1871
Query: 507 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS------------ 554
+ +E + E ++ +A D+I L ++ Q S +E+++S
Sbjct: 1872 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISG 1930
Query: 555 -------ESCEADPAEQLALQSTLTVLAERM--STIRMKA-SGKRQLLEEKLNDQLEEQR 604
+SC ++ +T + ++ +T R ++ K +L L D +++
Sbjct: 1931 NRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK-- 1988
Query: 605 QEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVV 662
Q Y + L + L + +AT LS P +P +++ QL + + + +I + V
Sbjct: 1989 ----YQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQV 2044
Query: 663 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE 722
A+ +L E +LL+ + + L + G +L ++++++ +Q
Sbjct: 2045 AVEKLKKTAE-VLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------- 2096
Query: 723 ESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSV 775
+T T+S VQ+ L + W +SSL++Q + L+ +++ L + +
Sbjct: 2097 -----ITLTRSLSVQDGLDE-MLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 2150
Query: 776 ASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESL--HQEFSTK 833
A R I + + + + S + M+ + + E+L +E TK
Sbjct: 2151 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 2210
Query: 834 QKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQS 893
+L +N+ E+ Q + L+ V DVP +D + L+Q +E +S+
Sbjct: 2211 VELFENL--SEKLQTFLETKTQALTEV-----DVPGKD-------VTELSQYMQESTSEF 2256
Query: 894 GGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEM 953
K+ L L + +++ LP + L L+K KEM
Sbjct: 2257 LEHKKHLEVLHSLLKE-----------------ISSHGLPSDKALVLEKTNNLSKKFKEM 2299
Query: 954 SEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQIL 1011
+ + + K + E D V+ +L + + +V + + L+
Sbjct: 2300 EDTIKEKKEAVTSC-QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTK 2358
Query: 1012 NFQN--DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKR 1069
Q LK +N I L L + P A+ I A++ +G L
Sbjct: 2359 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNG 2407
Query: 1070 RGDKLQVEQ--------PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQ 1120
G E+ ++++ + Y++L +++ + + LN L+ L+ E +
Sbjct: 2408 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSA 2467
Query: 1121 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHM--------ILTETLF 1172
+ L + + Q + E ++ ++++K + L+ ++ LTE L
Sbjct: 2468 MMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLE 2527
Query: 1173 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV 1232
+ + Q TE+ ++ + + R +LE + + +L + L
Sbjct: 2528 ENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEK 2587
Query: 1233 ESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---- 1288
E + +G + + + L + Q L +P+ Q+ G+ +L S D
Sbjct: 2588 ELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLR 2646
Query: 1289 --LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
++ QL + + W S T ++S ++ + T+YQS L+ L L+
Sbjct: 2647 GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQS----LLRSLSDKLSDLDNKL 2702
Query: 1347 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELS 1406
S+ V + + L + +E+ + + L L K + L++ELS
Sbjct: 2703 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE--YLKAELS 2760
Query: 1407 RIDSQWTDLLTNIPAVQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDED 1459
R Q +L + V++K Q S H ++ +W+ +K+E
Sbjct: 2761 R---QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD-----TKKEEQ 2812
Query: 1460 NIKNSIGYK--AIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 1517
N + I K + ++ +K F + + +++ + + ++++ S+K
Sbjct: 2813 NKSHPISAKLDVLESLIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQ 2869
Query: 1518 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 1577
QL + +W V E+ L+ LE +Y+ V+ L W + + L++ D
Sbjct: 2870 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2929
Query: 1578 QASVQNALKDCQDLE------------------DLIKAKEKEVEKIEQNGLALIQNKKED 1619
A +N++ + L+ L+ E + E + +LIQ K +
Sbjct: 2930 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDM 2988
Query: 1620 VSSIVMS---TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYS 1676
V+ + S L + Q + + + K L+ +Q H D + S +Y
Sbjct: 2989 VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY- 3043
Query: 1677 LSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLL 1722
L+ + SL+A++ QVD + L DL + E Q+ +++ Q+
Sbjct: 3044 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3103
Query: 1723 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 1782
++C L L+ + N + E ++ + L + +D A T+Q+Q
Sbjct: 3104 EKC-----SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQ 3153
Query: 1783 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
++ LK ++D + C +L T D +
Sbjct: 3154 KETIKAFLKKLEALMASNDNAN---KTCKMMLATEETSPDLV------------------ 3192
Query: 1843 ASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
I+ D +LS+ L ++ ++ + E F L+ + +AEE + Q
Sbjct: 3193 --GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQ 3250
Query: 1903 DPSHSSDLSTIQERMEELK-GQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL---- 1957
P + TI +++ K Q + + +N LG L + + Q L
Sbjct: 3251 GPV-GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL 3309
Query: 1958 ---NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQ 2012
N W ++ + +R ++LQ LL F + E+ + ++V TE+ +A + S ++
Sbjct: 3310 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3369
Query: 2013 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 2072
+ Q + +L Q + R+ + I +G+++ + D+ + +L+LL ++W+ ++
Sbjct: 3370 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3429
Query: 2073 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 2132
+A+ R ++ Q++ E E L +WL + + PI Q ++ Q
Sbjct: 3430 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIE---KRLVNCEPIGTQASKLEEQIAQ 3486
Query: 2133 FK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASM 2183
K E + V G+ L + + + +Q++L EIQEK S S
Sbjct: 3487 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3546
Query: 2184 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEE-LHAEQMRCKELE 2242
L++ +D E + + L ++ KL S+ D+ E L +Q + L+
Sbjct: 3547 LLQQALCNAKIFGED----EVELMNWLNEVHDKLSKL--SVQDYSTEGLWKQQSELRVLQ 3600
Query: 2243 NAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGER 2302
+ ++ Q L L + D++ I+ +++E ++ +++++ + + + +
Sbjct: 3601 EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQA 3660
Query: 2303 LNEWAVFSEKNKELCEWLTQMESK-VSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQ 2361
L ++ELC WL ++E + +S +L E + + +E A+ NK L
Sbjct: 3661 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD 3720
Query: 2362 QMGE---RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ E L + +E + + N+R++ + D I +V+++ ++ QQ D+
Sbjct: 3721 SLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAA 3780
Query: 2419 SSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL 2478
+ +W+ E +L + ++ +L Q+ +I +H + ++ ++
Sbjct: 3781 DAELSWITETEKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM 3839
Query: 2479 HDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 2538
C ++ E S+++ + + + IC ++ ER L++E L +F + Y W
Sbjct: 3840 TAC----SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3895
Query: 2539 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 2598
L ++ + + + Y +++ ++ + + E ++ +NK +L E
Sbjct: 3896 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGE 3954
Query: 2599 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 2658
S+++ + + +++ V L I Q +F D IL L + +L
Sbjct: 3955 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4014
Query: 2659 EHFSECDVQAKIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIE 2710
S +V+ KIK+ + + +S++ K+ E + +GE++I +S + + A ++
Sbjct: 4015 PSIS-AEVE-KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4072
Query: 2711 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 2770
++LD++ + + VE +RE +L D L++ W D +
Sbjct: 4073 DKLDQMVFIWENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS- 4112
Query: 2771 SLLSPQPSSNLSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAM 2823
+++ + + + L P ++ ++ +T +D + E D +L +L +A
Sbjct: 4113 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC 4172
Query: 2824 SRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIR-QLGKALDDSRFQIQQTENI--- 2879
G+ DK + L+ +L + ++ K + + +Q + +
Sbjct: 4173 ----------GEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4222
Query: 2880 ----------IRSKTPTGPELDT---SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 2926
+ S +P G +L+T + + E ++RL H+ + + +
Sbjct: 4223 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4282
Query: 2927 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 2986
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE
Sbjct: 4283 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4342
Query: 2987 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQ 3045
L ++ + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ
Sbjct: 4343 LS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ 4400
Query: 3046 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 3105
++L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 4401 NKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGG 4460
Query: 3106 ---------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 3150
N+ E+ ++ +K LMQ ++L + S + ++ +
Sbjct: 4461 LPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDIN 4513
Query: 3151 DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 3201
+ E E V N K L+E L ++ +S QD +W + E
Sbjct: 4514 NLKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4558
Score = 244 bits (624), Expect = 8e-64
Identities = 429/2257 (19%), Positives = 899/2257 (39%), Gaps = 262/2257 (11%)
Query: 37 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK----------VLAHGTIAWNSASQL 86
+Q + R +KL ++ +Y E +E + WI+K + A G + L
Sbjct: 2884 KQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSL 2943
Query: 87 REQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKI 146
+++ H ++E + L ++ E + T++ + ++ TE+L K
Sbjct: 2944 QKEMDQHFGMVELLNNTANSLLSVCE----IDKEVVTDENKSLIQKVDMVTEQLHSK-KF 2998
Query: 147 RLQNLQDAAKDMKKFEAELKK-LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMES 205
L+N+ K+ ++ E K+ LQ A EQ + + + L+ Q +++
Sbjct: 2999 CLENMTQKFKEFQEVSKESKRQLQCAKEQLD--IHDSLGSQAYSNKYLTMLQTQQKSLQA 3056
Query: 206 LKPKVQ-AVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 264
LK +V A +L Q + D + + + +E S L ++C+ ++ +
Sbjct: 3057 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3116
Query: 265 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 324
++ ++ + E++ + + LQ Q + +K++ + N
Sbjct: 3117 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3176
Query: 325 KCKMLTMKAKHATMLLTV-TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSP 383
CKM+ + + L+ + ++E L++ +LL A V T R S
Sbjct: 3177 TCKMMLATEETSPDLVGIKRDLEALSKQC----NKLLDRAQAREEQVEGTIKRLEEFYSK 3232
Query: 384 VTE-----ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 438
+ E + EE S+ PV ++NQ + ++ E ++ K
Sbjct: 3233 LKEFSILLQKAEEHEESQ----------GPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3282
Query: 439 HPSTSASQEFYEPGLEPSATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
Q + + ++T L D+ W+TL ++++ L EAL ++QD
Sbjct: 3283 QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQD 3342
Query: 495 SLQS-ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELV 553
+L+S +S ++ EL ++ P P ++ +A + E +LQ +++ +S++ E++
Sbjct: 3343 ALESLLSWMVDTEELVANQKP-----PSAEFKVVKAQIQEQKLLQRLLDDRKSTV--EVI 3395
Query: 554 SESCE-----ADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE-------------EK 595
E A+PA+++ + L++L R + KA + + LE E
Sbjct: 3396 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3455
Query: 596 LNDQLE--EQR---------QEQALQRYRCEADELDSWLLSTKATLDTALS--------P 636
LN+ L E+R Q L+ + L+ +++ L A+S
Sbjct: 3456 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLS 3515
Query: 637 PKEPMDMEAQLMD-CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE------QL 689
+E DM +D Q +EI++K + SEL + L K +DE E ++
Sbjct: 3516 SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL---QQALCNAKIFGEDEVELMNWLNEV 3572
Query: 690 AGKLRRL-------------KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGV 736
KL +L + L LQ + ++ N+ E T + +
Sbjct: 3573 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3632
Query: 737 QEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAG 796
Q+ L + + + S K LEQ L L R + S EE+ E
Sbjct: 3633 QDKLEAIKARYKDITKLSTDVAKTLEQAL----QLARRLHSTHEELCTWLDKVEV----- 3683
Query: 797 EKPDVLSQELG-MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 855
++LS E ++GE++S Q +M+ + L +E + LL + L + +L P R
Sbjct: 3684 ---ELLSYETQVLKGEEAS---QAQMRPKELKKEAKNNKALLDS-LNEVSSALLELVPWR 3736
Query: 856 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 915
G+ + +D + D + Q EE+ + +I Q+ A
Sbjct: 3737 AREGLE----KMVAEDNERYRLVSDTITQKVEEIDA--------AILRSQQFDQAADAEL 3784
Query: 916 TWLDDVEERLFVATALLPEETETC-------LFNQEILAKDIKEMSEEMDKNKNLFSQAF 968
+W+ + E++L + E+ +T F EIL K++ +++ K+ + A
Sbjct: 3785 SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH--KDIIDDLVKSGHKIMTAC 3842
Query: 969 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN-FQNDLKVLFTSLADN 1027
E + + ++ L +L + + ++R Q+ ER Q ++N F + L+ L +
Sbjct: 3843 SE--EEKQSMKKKLDKVLKNYDTICQINSERYLQL-ERAQSLVNQFWETYEELWPWLTET 3899
Query: 1028 KYIILQKLANVFE-QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP----SMQ 1082
+ II Q A E + + +Q E +Q + + E I ++ + G +L P S+Q
Sbjct: 3900 QSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQ 3959
Query: 1083 ELSKLQD-MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 1141
E D +Y ++ + R L++ ++ +Q+ + + + LE E++ I
Sbjct: 3960 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSIS 4018
Query: 1142 SSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRA 1201
+ E+I++ + ++K +E L ETL Q E++A++ K
Sbjct: 4019 AEVEKIKEQISENKNVSVDMEKLQPLYETL------------KQRGEEMIARSGGTDKDI 4066
Query: 1202 HKRGVE--LEYILETWSHL----DEDQQELSRQLEVVE-------SSIPSV----GLVEE 1244
+ V+ L+ ++ W ++ +E + +L +E+ E S I ++ + +
Sbjct: 4067 SAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD 4126
Query: 1245 NEDRLIDRITLYQH------LKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQ 1295
ED ID + Q ++ ++ Q +L V++ G L+ + D ++ +++
Sbjct: 4127 LEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDE 4186
Query: 1296 LGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQE 1355
L W S + +LE ++ +YQ + W+ A +L + + +
Sbjct: 4187 LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----PIGTD 4242
Query: 1356 LEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV----DTATLRSELSRIDSQ 1411
LE V+ + +F E Q ++ L+ +LL LKKV D T++ L +
Sbjct: 4243 LETVKQQIEELKQFKSEA-YQQQIEMERLNHQAELL-LKKVTEESDKHTVQDPLMELKLI 4300
Query: 1412 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--YKA 1469
W L I Q KL + +HA+ E+++W++ E ++ + + +G KA
Sbjct: 4301 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-----QKPVGGDPKA 4355
Query: 1470 IHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK-TDFAEQLGAMNKSWQ 1528
I L K+ + D+ Q TV+ VN++ + +ES ++ ++ +L +N+ WQ
Sbjct: 4356 IEIELAKHHVLQNDVLAHQSTVEAVNKA----GNDLIESSAGEEASNLQNKLEVLNQRWQ 4411
Query: 1529 ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNALKD 1587
+ ++ Q L+G L + ++ L+ W E+ L +G + + L
Sbjct: 4412 NVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4471
Query: 1588 CQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKI 1647
++ +AKE+ + + Q G ++ + + + + L + W +++ + + K
Sbjct: 4472 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4531
Query: 1648 LLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 1707
L+ L+ + ++L +A +L+ + L+ V Q+D + +++
Sbjct: 4532 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4591
Query: 1708 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS-------SKA 1760
+ + L + N L V RW +++ + E+ +S +K
Sbjct: 4592 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4651
Query: 1761 LLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTV 1820
+ W + ++ ++ ++ + + N+ D++ T + + K LG
Sbjct: 4652 FHEAWSKLMEWLEESEKSLDSELEIAND-----------PDKIKTQLAQHKEFQKSLGAK 4700
Query: 1821 KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE---QALC----KQQTSLQA 1873
+ G LK++ +++ D L L L L +C ++Q L+
Sbjct: 4701 HSVYDTTNRTGRSLKEK------TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4754
Query: 1874 GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 1933
+L F +L+AL W+ E L P H D+ + ++ K +
Sbjct: 4755 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSS 4813
Query: 1934 LDRLNELGYRLPLNDKEIK-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 1988
+ L L ++ +MQ L+ W + + + + ++L++ L Q + F
Sbjct: 4814 VQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV 4873
Query: 1989 CETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL 2046
+E+L + EQ L + + L H+ F ++ ++ L+ G +L
Sbjct: 4874 VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4933
Query: 2047 EQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV-E 2105
D +T++ +++ V+ A+Q + + S + +E+ E L WL
Sbjct: 4934 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 4993
Query: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQ-FKEKVFLRQ 2141
+ L +P +++ + L E Q F E++ +Q
Sbjct: 4994 ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5030
Score = 230 bits (587), Expect = 2e-59
Identities = 557/3213 (17%), Positives = 1245/3213 (38%), Gaps = 497/3213 (15%)
Query: 264 YEQYEQEMKHLQQLIEGAH----REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQI 319
Y Y E+++++ +E R+I P+ ++ E +I+ E+L ++++ ++ +
Sbjct: 1094 YNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDLHESVFRITEQEKLKKELERLKDDL 1152
Query: 320 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 379
++ +KC+ +A ++ + PT + +VV+ + ++
Sbjct: 1153 GTITNKCEEFFSQAAASSSV---------------------PTLRSELNVVLQNMNQVYS 1191
Query: 380 LLSP----------VTEESGEEGTNSEISSPPACRSPSPVANTDASVN--QDIAYYQALS 427
+ S V + + ++ C + +A+ + N + +++
Sbjct: 1192 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV 1251
Query: 428 AERLQTDAA---KIHPSTSASQEFYEPGLEPSAT-----AKLGDLQRSWETLKNVISEKQ 479
E+ Q A ++ + + S E ++ E K L W+ + I +
Sbjct: 1252 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1311
Query: 480 RTLYEALERQQKYQDSLQSISTKMEAIEL---KLSES-PEPGRSPESQMAEHQALMDEIL 535
R L + + Y+D+ + ++ +E K+ E+ PE ++ +Q+ + + L+ EI
Sbjct: 1312 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1371
Query: 536 MLQDEINELQS---------------SLAEELVSESCEADPAEQLALQSTLTVLAERMST 580
M Q +++E Q ++ + +S + P ++ +QS+ ++ +
Sbjct: 1372 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1431
Query: 581 IRMKASGKRQLLEEKLN---DQLEE-QRQEQALQRYRCE----ADELDSWLLSTKATLDT 632
+R + + L+ + + D L+ + +E++L+ + E A EL W+ + TL
Sbjct: 1432 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1491
Query: 633 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 692
A K P Q + + + + EQ AL + + L G T +E +L +
Sbjct: 1492 AEKAGKPP--FSKQKISSEEISTKKEQLSEALQTIQLF---LAKHGDKMTDEERNELEKQ 1546
Query: 693 LRRLKGS----LLELQRALHDKQLNMQGTAQEKEESDVD-------------LTATQSPG 735
++ L+ S E + L + Q + +EK ++ LT T++
Sbjct: 1547 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1606
Query: 736 VQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 795
+ A T + + +Q+EL++++ L V E L ++
Sbjct: 1607 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN--------- 1657
Query: 796 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQ--KLLQNVLEQEQEQVLYSRP 853
GEK LSQE E+ E +++ + +L E S K+ K++ +++E E+V +
Sbjct: 1658 GEK---LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1714
Query: 854 NRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSA 913
+ K+ + +LLD L+ + S+ G K + + +
Sbjct: 1715 LE--------------ESKTKIENLLDWLSNV--DKDSERAGTKHKQV---------IEQ 1749
Query: 914 TSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD 973
T + + + + + EE E N +L D+ + +NL Q
Sbjct: 1750 NGTHFQEGDGK-----SAIGEEDEV---NGNLLETDVD--GQVGTTQENLNQQYQKVKAQ 1799
Query: 974 NRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLF-TSLADNKYIIL 1032
+ +I ++ S + Q + E +++ +LKV + T+LA+++
Sbjct: 1800 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESE---- 1855
Query: 1033 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 1092
++++ ++ L++FDA E + LQ + ++ L D +
Sbjct: 1856 ------------KKMKLTHSLQEELEKFDADYTEFEH---WLQQSEQELENLEAGADDIN 1900
Query: 1093 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQ--EKMAGDQKIIVSSKEEIQQL 1150
LM + ++S ++ K +LE + K G + ++ E+Q+
Sbjct: 1901 GLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRK 1960
Query: 1151 LDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEY 1210
LD + F+ L S + + ++ Q L+A A A K
Sbjct: 1961 LDHATDRFRSLYSKCNVLGNNLKDLVD-KYQHYEDASCGLLAGLQACEATASK------- 2012
Query: 1211 ILETWSHLDE----DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 1266
HL E D + L RQLE ++ + + ++L + + SL
Sbjct: 2013 ------HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPA 2066
Query: 1267 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 1326
+ + + LDD I DL +N+ E +L+ L Q
Sbjct: 2067 KNDIQKTLDD-----IVGRYEDLSKSVNERNE--------------KLQITLTRSLSVQD 2107
Query: 1327 ESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
+++ W+ + + L ++ VP ++D ++ + +++ + S ++
Sbjct: 2108 GLDEMLDWMGNVESSL----KEQGQVPLNSTALQDIISKNIMLEQDIAG----RQSSINA 2159
Query: 1387 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 1446
N+ ++KK T S S + ++ DL K H+ + K+ E+ +
Sbjct: 2160 MNE--KVKKFMETTDPSTASSLQAKMKDLSARFSEASHK-HKETLAKM------EELKTK 2210
Query: 1447 ISLMENVIQKDEDNIKN--------SIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ L EN+ +K + ++ + K + E Q + + + ++ ++ +
Sbjct: 2211 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 2270
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 1558
+ISS + SDK E+ ++K ++ ++ + EK + + E ++ V+ L
Sbjct: 2271 KEISSHGLP---SDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2327
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL------ 1612
K+W + K++ + +L+D + L++ K E++K+ +G++L
Sbjct: 2328 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2387
Query: 1613 IQNKKEDVSSIVM--------STLRELGQTWAN------------LDHMVGQLKILLKSV 1652
+ + ++++ T + WAN + H L +LLK
Sbjct: 2388 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2447
Query: 1653 LDQWSSHKVAFDK-------INSYLMEARYSLSRFRLLTG--SLEAVQVQVDNLQNLQDD 1703
+ + ++ K + +L + + ++++ EAV+ QV+ ++ + +
Sbjct: 2448 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2507
Query: 1704 LEKQERSLQKFGSITNQLLKE-CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALL 1762
L++ +Q+ +LL+E P L E++ +W L + ++ Q +
Sbjct: 2508 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2567
Query: 1763 QLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKD 1822
+++ Q + ++E + L + + ++ + T Q LL+ T K
Sbjct: 2568 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN----TQRQQVQILLQEFATRKP 2623
Query: 1823 SLFFLHELGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYET 1880
L G+ + + D S ++ +++Q +L L + + ++
Sbjct: 2624 QYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ 2683
Query: 1881 FAKSLEALEAWIVEAEEILQG------QDPSHSSDLSTIQERMEEL---KGQMLKFSSMA 1931
+ L +L + + + L + + L T Q+ +E+ K Q+ ++
Sbjct: 2684 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC 2743
Query: 1932 PDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL---QHQTFLEK 1988
DL L + Y L + ++++ + + + + + LQS Q Q
Sbjct: 2744 EDLSALVKEEY---LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2800
Query: 1989 CETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ 2048
+ W++ + EQ + IS L + H+ F + ++ + I +G+ LL +
Sbjct: 2801 FQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2859
Query: 2049 GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKW------ 2102
Q ++ L+L + W ++ ++R + + + +Y+E E L W
Sbjct: 2860 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2919
Query: 2103 -LVEVSYL--PMSG-----------------LGSVPIPLQQARTLFDEVQFKEKVFLRQQ 2142
L E+ + P G G V + A +L + ++V +
Sbjct: 2920 NLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN 2979
Query: 2143 GSYILTVE------------------------------------AGKQLLLSADSGAEAA 2166
S I V+ A +QL + G++A
Sbjct: 2980 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3039
Query: 2167 LQAELAEIQEKWKS--ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK---LS 2221
L +Q + KS A + K+LA L KG +D L ++ T ++ LS
Sbjct: 3040 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3099
Query: 2222 QSLPDHHEELHAE-------QMRCKELENAVGSWTDDLTQLSLL----------KDTLSA 2264
Q + + L + Q +E+ + + D+L ++ + K+T+ A
Sbjct: 3100 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3159
Query: 2265 YI-------------------------SADDISILNERVELLQRQWEELCHQLSLRRQQI 2299
++ ++ D+ + +E L +Q +L + R +Q+
Sbjct: 3160 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3219
Query: 2300 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQ 2354
+ F K KE L + E G + I + + K +EEI Q
Sbjct: 3220 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3279
Query: 2355 ENKIQLQQMGERLAKASHESKASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ 2413
+ + +G+ L +++ +S +++ +E+ L VN RW+ L +A R +L+E L+ +
Sbjct: 3280 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3339
Query: 2414 LDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
+ SL +W+ E +A KP S + ++ ++ EQ+ LQR ++ + V
Sbjct: 3340 FQDALESLLSWMVDTEELVANQKP---PSAEFKVVKAQIQEQKLLQRLLDDRKSTV---- 3392
Query: 2472 NLCEVLLHDCDACATDAE-CDSIQ--QATRNLDRRWRNICAMSMERRLKIEETWRLWQKF 2528
EV+ + + AT AE D ++ + LD RW + + R ++E + Q+F
Sbjct: 3393 ---EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3449
Query: 2529 LDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV---HECLTQLELINK 2585
+ +WL + E+ G + +E++ + +A + + ++ L Q I +
Sbjct: 3450 HETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ 3509
Query: 2586 QYRRLARENRTDSACSLKQMVHEGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSI 2644
+ L+ D + Q + +Q W +Q++ S L+ + + F +
Sbjct: 3510 SLKVLSSREDKD----MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVEL 3565
Query: 2645 LVWLTEMDLQLT--NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 2702
+ WL E+ +L+ +++ +S + + +L+ Q++I L ++Q + G +L++++
Sbjct: 3566 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTT 3625
Query: 2703 PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDL 2762
+ II+++L+ ++ +++ L D ++ L+L + L
Sbjct: 3626 GDEVLIIQDKLEAIKARYKDI-------------TKLSTDVAKTLEQALQL--ARRLHST 3670
Query: 2763 H-----WHDRSADSLLSPQ----PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 2813
H W D+ LLS + S + +P ++ ++ A +DS+
Sbjct: 3671 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL-------- 3722
Query: 2814 DLSRDLESAMSRALPSEDEEG-----QDDKDFYLRGAVGLSGDHSALESQI---RQLGKA 2865
++ SA+ +P EG +D + Y + ++ +++ I +Q +A
Sbjct: 3723 ---NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3779
Query: 2866 LDDSRFQIQQTENIIRS-------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
D I +TE + S + T +L M++L ID + + HK+
Sbjct: 3780 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDLVKSGHKI 3838
Query: 2919 ----KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLN 2974
EEE+ S + + V+ ++ + + L++++ QF
Sbjct: 3839 MTACSEEEK--------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3890
Query: 2975 SIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFT 3034
+W WL +T+ + QL L + +T+ Q ++ ++L++ + K I +N P+
Sbjct: 3891 ELWPWLTETQSIISQLPAPAL--EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3948
Query: 3035 QADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 3094
+ E +Q++ + + ++ +++ L +A+ Q FH+ +L LE I
Sbjct: 3949 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4008
Query: 3095 RRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE 3154
R + P + + E +++ + + ++ + Q +L+ +++ + GTD
Sbjct: 4009 ERLRQ--PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI 4066
Query: 3155 AKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDV 3186
+ + V +++ + + + ++E E KLLDV
Sbjct: 4067 SAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4099
Score = 210 bits (534), Expect = 2e-53
Identities = 462/2514 (18%), Positives = 971/2514 (38%), Gaps = 299/2514 (11%)
Query: 21 LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 80
L++++ + + + ++AEN + L A + ++ +M W++ K
Sbjct: 2759 LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQ 2812
Query: 81 NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEEL 140
N + + + + ++L+++ K+ L A + ++ E + + G E L
Sbjct: 2813 NKSHPISAKLDVLESLIKDHKDFSKTLTAQS----HMYEKTIAEGENLLLKTQGSEKAAL 2868
Query: 141 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLL 200
+ + N K +K+ E KL+ +LE+A L KEQ+ + L
Sbjct: 2869 QLQLNTIKTNWDTFNKQVKERE---NKLKESLEKA-----------LKYKEQV---ETLW 2911
Query: 201 SEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------ 254
++ + ++ ++ C E+ +A L LQ+E QH + +
Sbjct: 2912 PWIDKCQNNLEEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTAN 2962
Query: 255 NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEE 307
+++ + E E K L Q ++ ++ K N+ QE+ + R +
Sbjct: 2963 SLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ 3022
Query: 308 LAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLA--------------EGTE 353
A++ + + S K LTM L + LA +GT
Sbjct: 3023 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTS 3082
Query: 354 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSP 408
D+ ++ H ++ +C L + + + T E+ S A S +P
Sbjct: 3083 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3142
Query: 409 VANTDASVNQD----IAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL 464
V ++ + A+ + L A D A + E P L L L
Sbjct: 3143 VGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL-VGIKRDLEAL 3201
Query: 465 QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---E 521
+ L + ++ + ++R +++ L+ S I L+ +E E + P E
Sbjct: 3202 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGME 3256
Query: 522 SQMAEHQALMDEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLA 575
++ Q M ++ ++EI LQ L + L+ + ++ + L+ L +
Sbjct: 3257 TETINQQLNMFKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVN 3313
Query: 576 ERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALS 635
R T+ K + + L+E L L R + AL + L SW++ T+ +
Sbjct: 3314 ARWKTLNKKVAQRAAQLQEAL---LHCGRFQDAL-------ESLLSWMVDTEELVANQKP 3363
Query: 636 PPKEPMDMEAQ---------LMDCQNMLVEI--------------EQKVVALSELSVHNE 672
P E ++AQ L+D + VE+ KV L +LS+ +
Sbjct: 3364 PSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3423
Query: 673 NL-LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLT 729
L KA T++ R+L+G + Q+ H+ + LN T EK + +
Sbjct: 3424 RWEALLNKAETRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPI 3473
Query: 730 ATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA- 788
TQ+ ++E +AQ + + K L Q ++ +S L+ ++SR ++ ++Q
Sbjct: 3474 GTQASKLEEQIAQHKAL----EDDIINHNKHLHQAVSIGQS-LKVLSSREDKDMVQSKLD 3528
Query: 789 ------AETSGDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFST 832
E + + ++L Q L K ED++ M W +H Q++ST
Sbjct: 3529 FSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST 3586
Query: 833 KQK-LLQNVLEQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEE 888
+ Q+ L QE +L + N LL+G+ L K + + L+ + +++
Sbjct: 3587 EGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKD 3645
Query: 889 VSSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQ 943
++ S + Q++ L ++L+ TWLD VE L + L EE
Sbjct: 3646 ITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP 3705
Query: 944 EILAKDIKEMSEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVV 996
+ L K+ K +D + N S A E G + V ED R L+ +
Sbjct: 3706 KELKKEAKNNKALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTI 3759
Query: 997 NQRCHQMKERLQQILNFQN--DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAE 1054
Q+ ++ + + F D ++ + + + K + L + +Q A+
Sbjct: 3760 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3819
Query: 1055 DGLKEFDAGIIELKRRGDKL------QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN 1108
+ L+ D I +L + G K+ + +Q ++L K+ YD + I R L +
Sbjct: 3820 EILRHKDI-IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERA 3878
Query: 1109 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILT 1168
+L +Q+ ++L L T + + E ++Q ++H++ + + H
Sbjct: 3879 QSLVNQFWETYEELWPWL-TETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 3937
Query: 1169 ETLFR---KII------SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLD 1219
+ + + +++ F++Q++ L +Q +K KR V L+ + +
Sbjct: 3938 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK---KRAVALDEAISQSTQFH 3994
Query: 1220 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 1279
+ ++ LE + + + +++ ++I+ +++ + + QP LY+ L
Sbjct: 3995 DKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQP-LYETLKQRGE 4053
Query: 1280 LLIS--------ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 1331
+I+ IS ++ +L+Q+ W + + + +L +++ ++ + L
Sbjct: 4054 EMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4113
Query: 1332 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 1391
I ++ +D + + + +V+ A +E+D V++ G++L+
Sbjct: 4114 IVTIKDTQDFIRDLEDPGI----DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4169
Query: 1392 -RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM 1450
+ D ++ + ++S W L +KL + + + + V W+ +
Sbjct: 4170 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4229
Query: 1451 ENVIQKDEDNIKNSIG--YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 1508
+ + IG + + + +++ K FK + +Q+ ++ +N + + E
Sbjct: 4230 GGKLAS-----MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE- 4283
Query: 1509 KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 1568
SDK + L + W L+ + + LEG L + ++++ + L W E
Sbjct: 4284 -ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4342
Query: 1569 LKQQHRI-GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 1627
L +Q + GD +++ L L++ + A + VE + + G LI++ + +S + +
Sbjct: 4343 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4402
Query: 1628 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSL 1687
L L Q W N+ Q K L L Q + + +L + L + L G
Sbjct: 4403 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4462
Query: 1688 EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNL 1747
E + Q++ + E +E + + Q+L C + + + +W ++
Sbjct: 4463 ETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4522
Query: 1748 LEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWI 1807
++ E+ + L L + + + + + Q E + L A+ + D V I
Sbjct: 4523 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE----QTLNVASRPSLILDTVLFQI 4578
Query: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
+ + + ++ + L + G LK I++ +S+ + Q L ++
Sbjct: 4579 DEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4638
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
SL + F ++ L W+ E+E+ L + ++D I+ ++ + K
Sbjct: 4639 GRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD-SELEIANDPDKIKTQLAQHKEFQKSL 4697
Query: 1928 SSMAPDLDRLNELGYRL----PLNDKEIK---RMQNLNRHWSLISSQTTERFSKLQSFLL 1980
+ D N G L L D +K + L W I ++ ER +KL+ LL
Sbjct: 4698 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4757
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSI 2038
F + + +++L + E +LA + + G+ ++ H+ FQ E+ R + ++
Sbjct: 4758 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL 4817
Query: 2039 IIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
+ L+E G DD +++ LS +W+ V + ++ +++ +RQ + + +
Sbjct: 4818 KRSARELIE-GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4876
Query: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158
L +WL E + G +P RTL D+ + K ++ G +L
Sbjct: 4877 LLEWLAEAEQ-TLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI 4935
Query: 2159 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF----LLKDWEKCEKGIADSLEKLR 2214
+ ++ + I+ +++ ++ +++LA L+ E E +A
Sbjct: 4936 CHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAET 4995
Query: 2215 TFKKKLSQSLPDHHEELHA---------EQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
T K + +P EE+ A E+M K+ + V T + + +L ++
Sbjct: 4996 TLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPD--VDKVTKTYKRRAADPSSLQSH 5053
Query: 2266 I----------------------SADDISILNERVELLQRQWEELCHQLSLRRQQIG--- 2300
I S I N RV LL +W+++ RR+++
Sbjct: 5054 IPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDAL 5113
Query: 2301 ---ERLNEWAVFSEK--NKELCEWLTQMESKV---------SQNGDILIEEMIE 2340
E L E+A F K+ W+ +S+V Q+G I +E I+
Sbjct: 5114 DRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFID 5167
Score = 203 bits (516), Expect = 3e-51
Identities = 501/2642 (18%), Positives = 1024/2642 (38%), Gaps = 403/2642 (15%)
Query: 2 ELDAAVQKFLEQNGQLGKP---LAKKIGKLTELHQQTIRQAENRLSKLNQAAS------- 51
+L A QK+ GQL + + I K T+ +Q +R ++LS L+ S
Sbjct: 2652 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ-YQSLLRSLSDKLSDLDNKLSSSLAVST 2710
Query: 52 HLEEYNEMLELILKWI-----EKAKVLAHGTIAWNSASQLREQYILHQT------LLEES 100
H + N+ LE K EK ++ + + ++ ++E+Y+ + +L+
Sbjct: 2711 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSF 2770
Query: 101 KEIDSELEAMTEKLQYLTSVYCTEKMSQQVA-------ELGRETEELRQMIKIRLQNLQD 153
K+++ + E +Q+L S + QQ++ + +E + I +L L+
Sbjct: 2771 KDVEQKAE---NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLES 2827
Query: 154 AAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV 213
KD K F K L A + T+ E L LK Q S + L ++ ++K
Sbjct: 2828 LIKDHKDFS---KTLTAQSHMYEKTIAEGE--NLLLKTQGSEKAALQLQLNTIKTNWDTF 2882
Query: 214 ------------QLCQSALRIPEDVVASLPL---CHAALR-------------------- 238
+ + AL+ E V P C L
Sbjct: 2883 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2942
Query: 239 LQEEASRLQHTAIQQC------NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVAT 292
LQ+E QH + + +++ + E E K L Q ++ ++ K
Sbjct: 2943 LQKEMD--QHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3000
Query: 293 SNI-------QELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 345
N+ QE+ + R + A++ + + S K LTM L +
Sbjct: 3001 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3060
Query: 346 EGLAE--------------GTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEE 391
LA+ GT D+ ++ H ++ +C L + + +
Sbjct: 3061 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3120
Query: 392 GTNSEISSPPA-----CRSPSPVANTDASVNQDI----AYYQALSAERLQTDAAKIHPST 442
T E+ S A S +PV ++ + A+ + L A D A
Sbjct: 3121 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 3180
Query: 443 SASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTK 502
+ E P L L L + L + ++ + ++R +++ L+ S
Sbjct: 3181 MLATEETSPDLV-GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS-- 3237
Query: 503 MEAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSS------LAEELV 553
I L+ +E E + P E++ Q M ++ ++EI LQ L + L+
Sbjct: 3238 ---ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ-KEEIEPLQGKQQDVNWLGQGLI 3293
Query: 554 SESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYR 613
+ ++ + L+ L + R T+ K + + L+E L L R + AL+
Sbjct: 3294 QSAAKSTSTQ--GLEHDLDDVNARWKTLNKKVAQRAAQLQEAL---LHCGRFQDALE--- 3345
Query: 614 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQ---------LMDCQNMLVEI------- 657
L SW++ T+ + P E ++AQ L+D + VE+
Sbjct: 3346 ----SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3401
Query: 658 -------EQKVVALSELSVHNENL-LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD 709
KV L +LS+ + L KA T++ R+L+G + Q+ H+
Sbjct: 3402 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRN---------RQLEGISVVAQQ-FHE 3451
Query: 710 --KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 767
+ LN T EK + + TQ+ ++E +AQ + + K L Q ++
Sbjct: 3452 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKAL----EDDIINHNKHLHQAVSI 3507
Query: 768 QKSLLRSVASRGEEILIQHSA-------AETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 820
+SL + ++SR ++ ++Q E + + ++L Q L K ED++
Sbjct: 3508 GQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVE 3564
Query: 821 -MKW-ESLH--------QEFSTKQKLLQ-NVLEQEQEQVLYSRPN---RLLSGVPLYKGD 866
M W +H Q++ST+ Q + L QE +L + N LL+G+ L K
Sbjct: 3565 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLK-Q 3623
Query: 867 VPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEE 923
+ + L+ + +++++ S + Q++ L ++L+ TWLD VE
Sbjct: 3624 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3683
Query: 924 RL--FVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPE-------NGDN 974
L + L EE + L K+ K +D + N S A E G
Sbjct: 3684 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD-SLNEVSSALLELVPWRAREGLE 3742
Query: 975 RDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 1034
+ V ED R L+ + Q+ ++ + +
Sbjct: 3743 KMVAEDN-----ERYRLVSDTITQKVEEIDAAILR------------------------- 3772
Query: 1035 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 1094
+ F+Q ++ I + E L +E + +LQV++ E+ + +D+ D+L
Sbjct: 3773 -SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3831
Query: 1095 MMIIGSRRSGLNQN--LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 1152
+ + ++ ++K + ++ L++ + + E+ E Q L++
Sbjct: 3832 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYL--------QLERAQSLVN 3883
Query: 1153 KHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYIL 1212
+ E ++ L LTET + IIS +L A A LEY
Sbjct: 3884 QFWETYEELWPW--LTET--QSIIS-----------QLPAPA-------------LEY-- 3913
Query: 1213 ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQ 1272
ET QQE RQL L+ E++ + +N+ P+L +
Sbjct: 3914 ETL----RQQQEEHRQLRE---------LIAEHKPHI-----------DKMNKTGPQLLE 3949
Query: 1273 VLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLI 1332
L G+ I ++ +Q+ E + K L+ + T++ + ++
Sbjct: 3950 -LSPGEGFSIQEKYVAADTLYSQIKE-------DVKKRAVALDEAISQSTQFHDKIDQIL 4001
Query: 1333 HWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR 1392
L+ +RL +Q ++ E+E +++ ++ S +++ L ++ G +++
Sbjct: 4002 ESLERIVERL----RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 4057
Query: 1393 L-----KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 1447
K + ++ +L ++ W ++ T + + KL L + +L + MS I
Sbjct: 4058 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKL--LDVMELAEKFWCDH-MSLI 4114
Query: 1448 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVE 1507
+++ D I + + + + + +I+ Q +D V + + S+ +
Sbjct: 4115 VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIV----INLGSELIA 4170
Query: 1508 S-KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 1566
+ DK + + +N +W L ++I LE +++ +Y++ +Q + W +
Sbjct: 4171 ACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 4230
Query: 1567 KRLKQQHRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSS-IV 1624
+L IG D +V+ +++ + + ++ E+E++ L++ E+ V
Sbjct: 4231 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTV 4290
Query: 1625 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLT 1684
L EL W +L+ + + L+ L + A D++ ++L LS + +
Sbjct: 4291 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4350
Query: 1685 GSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRW 1744
G +A+++++ LQ+D+ + +++ N L++ L N L+ +N RW
Sbjct: 4351 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4410
Query: 1745 NNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN---KDIADD 1801
N+LE+ ++ Q L+ + K + + Q D LL + + A +
Sbjct: 4411 QNVLEKTEQRKQQLDGALR---QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKE 4467
Query: 1802 EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE 1861
++ ++ C T K L + G+Q+ + SA + I D +L + ++E
Sbjct: 4468 QLNVHMEVCAAFEAKEETYKS----LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4523
Query: 1862 QALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELK 1921
L +++T L+ + F SL+ W+ +AE+ L S L T+ +++E K
Sbjct: 4524 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP-SLILDTVLFQIDEHK 4582
Query: 1922 GQMLKFSSMAPDLDRLNELGYRLPL--NDKEIKRMQNL----NRHWSLISSQTTERFSKL 1975
+ +S + L++ G L +++ ++NL W + + ER L
Sbjct: 4583 VFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL 4642
Query: 1976 QSFLLQHQTFLEKCETWMEFLVQTEQKL--AVEISGNYQHLLEQQRAHELFQAEMFSRQQ 2033
+ + F E ME+L ++E+ L +EI+ + + Q H+ FQ + ++
Sbjct: 4643 DDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHS 4702
Query: 2034 ILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRY 2092
+ + G+ L E+ + DD + + L+ L ++W + ++ +R+ ++ + ++
Sbjct: 4703 VYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4762
Query: 2093 REMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAG 2152
+ + L WL V ++ V + L D K F ++ G +V+A
Sbjct: 4763 TDALQALIDWLYRVEP-QLAEDQPVHGDIDLVMNLIDN----HKAFQKELGKRTSSVQAL 4817
Query: 2153 KQL---LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADS 2209
K+ L+ + ++ ++ E+ +W++ ++ +L L+ E+ +
Sbjct: 4818 KRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL 4877
Query: 2210 LEKLRTFKKKLSQS--LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS 2267
LE L ++ L LPD + L + KE + +L + + + DT+ A
Sbjct: 4878 LEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICH 4937
Query: 2268 ADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV 2327
D I+ + + +++ ++EE+ +Q++ L E + L WL E+ +
Sbjct: 4938 PDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTL 4997
Query: 2328 SQNGDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAK-----ASH---- 2372
+ +I + IE++K + + EE+ Q + ++ + +R A SH
Sbjct: 4998 TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVL 5057
Query: 2373 -----------------ESKASEIEYKLGKVN---DRWQHLLDLIAARVKKLKETLVAVQ 2412
++IE K +VN +WQ + L R +KL + L ++
Sbjct: 5058 DKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLE 5117
Query: 2413 QL 2414
+L
Sbjct: 5118 EL 5119
Score = 182 bits (462), Expect = 5e-45
Identities = 617/3357 (18%), Positives = 1313/3357 (39%), Gaps = 415/3357 (12%)
Query: 28 LTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLR 87
L L IR+ + S L+Q + E + ++ +L W+++ +V T W S
Sbjct: 605 LQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT-EWGSDLPSV 663
Query: 88 EQYIL-HQTLLEESKEIDSEL-EAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIK 145
E ++ H+ + +E +S L EA ++Q + T ++++ L + +L +
Sbjct: 664 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT--YAEKLHRLESQYAKLLNTSR 721
Query: 146 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMES 205
+ ++L + + EL L E+ A S ++ K+ + L+ E++
Sbjct: 722 NQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKD--YHAELMRELDQ 779
Query: 206 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ-- 263
+ +++VQ L + E+ A L + +Q + S + +Q C ++ + +
Sbjct: 780 KEENIKSVQEIAEQLLL-ENHPARLTIEAYRAAMQTQWSWI----LQLCQCVEQHIKENT 834
Query: 264 -YEQYEQEMKHLQQLIEGAHREIEDKPVA--TSNIQELQAQISRHEELAQKIKGYQEQIA 320
Y ++ + K + I+ K +S+I +L+ + E +++ Y+ IA
Sbjct: 835 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 894
Query: 321 SLNSKCK-MLTMKAKHATM-LLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 378
+L K K ++ +K +++ L T ++ + + + + + + A H
Sbjct: 895 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI-------EITIYKDDECVLANNSH 947
Query: 379 TLLSPVTEESGEEGTNSEI--SSPPACRSPSPVANTDASVNQDIAYY---------QALS 427
V +G E + + PP + +AN Q++ +S
Sbjct: 948 RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 1007
Query: 428 AERLQTDAAKIHPSTSAS----------------QEFYEPGLEPSATAKL--GDLQRSWE 469
L + +I S AS Q +E LE S +++ G E
Sbjct: 1008 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1067
Query: 470 TLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPE----PGRSP----- 520
NV + + L ++ ER+++ + +++ I L+L + R+P
Sbjct: 1068 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1127
Query: 521 --ES--QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 576
ES ++ E + L E+ L+D++ + + EE S++ + L+S L V+ +
Sbjct: 1128 LHESVFRITEQEKLKKELERLKDDLGTITNK-CEEFFSQAAASSSVP--TLRSELNVVLQ 1184
Query: 577 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 636
M+ + +S L+ Q E ++ Y + E ++ +++ K ++ +S
Sbjct: 1185 NMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA-VIADKNNIENLIST 1243
Query: 637 PKEPMDMEAQLMDCQNMLVEIEQKVVALS-ELSVHNENLLLEGKAHTKDEAEQLAGKLRR 695
K+ + + L + QK A+S E+ + L+ H K++A+QL + R
Sbjct: 1244 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH-KEKADQL---VER 1299
Query: 696 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSL 755
+ +++ L D ++G + + T P + +W+ Q TT + +++
Sbjct: 1300 WQNVHVQIDNRLRD----LEGIGKSLKY----YRDTYHP-LDDWIQQVETTQRKIQENQP 1350
Query: 756 QQQKELEQELAEQKSLLRSVASRGEEI-LIQHSAAETSGDAGE-KPDVLSQELGMEGEKS 813
+ K L +L +QK L+ + + ++ Q A + S + + ++ ++ ++
Sbjct: 1351 ENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1410
Query: 814 SAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS 873
S + RM+ S+ ++Q ++ L +R L++ + Y K
Sbjct: 1411 SPVKRRRMQ--------SSADLIIQEFMD------LRTRYTALVTLMTQY-------IKF 1449
Query: 874 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLP 933
A SL + EE K++ + ++L VS S L D E+ A P
Sbjct: 1450 AGDSL-----KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK------AGKP 1498
Query: 934 EETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 993
++ + ++EI K KE E + LF ++GD + D
Sbjct: 1499 PFSKQKISSEEISTK--KEQLSEALQTIQLF---LAKHGD----------------KMTD 1537
Query: 994 SVVNQRCHQMKERLQQILN--FQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQ 1051
N+ Q+K LQ+ N F LK L S + +K+ +Q E+++ I
Sbjct: 1538 EERNELEKQVK-TLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGIC 1596
Query: 1052 QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111
+ G E GD EL K Q +EL + L +
Sbjct: 1597 DLLTQTENRLIGHQEAFMIGD-------GTVELKKYQSKQEELQKDMQGSAQALAE---- 1645
Query: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 1171
+++ + L+ EK++ + K + I+Q L++ K + L ++
Sbjct: 1646 ------VVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLNLKAEQSKKE 1693
Query: 1172 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL-SRQLE 1230
K+++ A+++ET + A +K+ + ++E +L+ S++D+D + ++ +
Sbjct: 1694 LDKVVTTAIKEET--------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQ 1745
Query: 1231 VVESS---------IPSVGLVEENEDRLIDRI------TLYQHLKSSLNEYQPKLYQVLD 1275
V+E + ++G +E L++ T ++L + + + +++
Sbjct: 1746 VIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIIS 1805
Query: 1276 DGKRLLISISCSD--LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIH 1333
+ ++I+ + LE Q L K+ K + L+ + + L H
Sbjct: 1806 QHQAVIIATQSAQVLLEKQGQYLSP---EEKEKLQKNMKELKVHYETALAESEKKMKLTH 1862
Query: 1334 WLQSAKDR-------LEFWTQQSVTVPQELEMVRDHLNAFL-------EFSKEVDAQSSL 1379
LQ ++ E W QQS + LE D +N + FS++V +
Sbjct: 1863 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1922
Query: 1380 KSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 1439
+ +GN++L K S+ D D VQ KL D+ S ++
Sbjct: 1923 LRYITISGNRVLEAAK--------SCSKRDGGKVDTSATHREVQRKLDH-ATDRFRSLYS 1973
Query: 1440 ISEVM--SWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQS 1497
V+ + L++ ++ + G +A K+ I ++ K L
Sbjct: 1974 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2033
Query: 1498 VL--QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 1555
L QISSQ V ++ KT AE L S + + + + + G E S+ N
Sbjct: 2034 ALQGQISSQQVAVEKLKKT--AEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN-- 2089
Query: 1556 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 1615
E+ K Q + SVQ+ L + D +++ KE ++ N AL
Sbjct: 2090 ----------ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL--- 2136
Query: 1616 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV-LDQWSSHKVAFDKINSYLMEAR 1674
+D+ S + +++ ++++ M ++K +++ SS + +++ EA
Sbjct: 2137 --QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEAS 2194
Query: 1675 YSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP---VTE 1731
+ + + +E ++ +V+ +NL + LQ F Q L E P VTE
Sbjct: 2195 H---KHKETLAKMEELKTKVELFENLSE-------KLQTFLETKTQALTEVDVPGKDVTE 2244
Query: 1732 TLTNTLKEVNMRW----------NNLLEEIAEQ-LQSSKAL-LQLWQRYKDYSKQCASTV 1779
L+ ++E + ++LL+EI+ L S KAL L+ K+ T+
Sbjct: 2245 -LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTI 2303
Query: 1780 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 1839
+++++ + + + +WI++ K + V+ S F +LG+ L+
Sbjct: 2304 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETT---KKVPIVQPS-FGAEDLGKSLEDTKK 2359
Query: 1840 ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL 1899
++++ ++ Q + SL + T AK++ A+++ +L
Sbjct: 2360 LQEKWSLKTPEI----------QKVNNSGISLCNLISAVTTPAKAIAAVKS----GGAVL 2405
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNR 1959
G+ + +++ + + +K M S DL L L DK + LN
Sbjct: 2406 NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLL--------LKDK----IAELNT 2453
Query: 1960 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQR 2019
S + E + +Q ++T W + T+ + AV+ +EQ +
Sbjct: 2454 KLSKLQKAQEESSAMMQWLQKMNKT----ATKWQQTPAPTDTE-AVKTQ------VEQNK 2502
Query: 2020 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
+ E + ++ Q L + + L E + + LT + ++WQ + + R+
Sbjct: 2503 SFEAELKQNVNKVQELKDKLT--ELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2560
Query: 2080 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 2139
++ +++ + +L++WLVE L +S LG + I T +VQ + F
Sbjct: 2561 QKLEESSNNLTQFQTVEAQLKQWLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2619
Query: 2140 RQQGSYILTVEAGKQLLL--SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 2197
++ Y AG+ +L D ++ +LA + +KW S + +L ++ + +
Sbjct: 2620 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2679
Query: 2198 DWEKCEKGIADSLEKLRTFKKKLSQSL--PDHHEELHAEQMRCKELENAVGSWTDDLTQL 2255
+ + + +KL KLS SL H + ++ + ++++ + +
Sbjct: 2680 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2739
Query: 2256 SLLKDTLSAYISADDISI-LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK 2314
L + LSA + + + L+ ++E + + ++++ + Q + F + ++
Sbjct: 2740 QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSR 2799
Query: 2315 ELCEWLTQMESKVSQNGDILIE-EMIEKLKKDYQE--EIAIAQENKIQLQ-QMGERLAKA 2370
+ WL + + +++ I + +++E L KD+++ + AQ + + GE L
Sbjct: 2800 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2859
Query: 2371 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 2430
+ S+ + ++ +L + W + R KLKE+L + + + +L W+ ++
Sbjct: 2860 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2919
Query: 2431 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD---ACATD 2487
L + + + E + + + + LQ+++++H V + N LL C+ TD
Sbjct: 2920 NLEE--IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2977
Query: 2488 AECDSIQQATRNLDR-RWRNICAMSMERRLK-IEETWRLWQKFLDDYSRFEDWLKSSERT 2545
IQ+ ++ + C +M ++ K +E + ++ L D + S +
Sbjct: 2978 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD-IHDSLGS 3036
Query: 2546 AAFPSSSGVIYTVAKEELKKFEAFQRQV--------------------HECLTQLELINK 2585
A+ S T+ + + K +A + QV + L Q+E I +
Sbjct: 3037 QAY---SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQ 3093
Query: 2586 QYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSIL 2645
++ L+++ D CS + +G + N ++ Q EF+ DS
Sbjct: 3094 EHSTLSQQ--VDEKCSFLETKLQGIGHFQN----------TIREMFSQFAEFDDELDS-- 3139
Query: 2646 VWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 2705
+ + ++ E ++A +K+L+A + + ++A E++ P D
Sbjct: 3140 --MAPVGRDAETLQKQKE-TIKAFLKKLEALMASNDNANKTCKMMLA-----TEETSP-D 3190
Query: 2706 AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 2765
I+ +L+ L + C ++ R + +++ +E +E S L H
Sbjct: 3191 LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF----SILLQKAEEH 3246
Query: 2766 DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR 2825
+ S + + N L++ + + E P + W L + L + ++
Sbjct: 3247 EESQGPVGMETETINQQLNMFKVFQKEEI---EPLQGKQQDVNW-----LGQGLIQSAAK 3298
Query: 2826 ALPSED-EEGQDDKDFYLRGAVGLSGDHSA-LESQIRQLGK---ALDDSRFQIQQTENII 2880
+ ++ E DD + + +A L+ + G+ AL+ + TE ++
Sbjct: 3299 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3358
Query: 2881 RSKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST 2934
++ P E K +LL + S+++ +KR K+ E L
Sbjct: 3359 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL--- 3415
Query: 2935 ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE 2994
Q + + RWE L +A ++ +++ QQF+ L + WL E+ L +
Sbjct: 3416 -KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE--P 3472
Query: 2995 LSTDIQTIELQIKKLKELQ-KAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQMN 3052
+ T +E QI + K L+ ++H K + ++++ S+E +D+ Q +L
Sbjct: 3473 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQ 3531
Query: 3053 GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL 3112
+ + LLQ AL + F E L+ L + + +++ D E L
Sbjct: 3532 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD--YSTEGL 3589
Query: 3113 QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKE 3172
+L ++ ++L + V +LL G + L ++K+ I R K + K
Sbjct: 3590 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3649
Query: 3173 VSRHIKELEKLLDVS----SSQQDLSSWSSADELD-TSGSVSPTSGRSTPNRQKTPR 3224
+ K LE+ L ++ S+ ++L +W E++ S G Q P+
Sbjct: 3650 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3706
Score = 96.3 bits (238), Expect = 5e-19
Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)
Query: 1330 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 639 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 691
Query: 1387 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 1446
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 692 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 743
Query: 1447 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 1506
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 744 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 795
Query: 1507 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 1565
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 796 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 853
Query: 1566 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 1623
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 854 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 906
Query: 1624 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 1678
+T + + +I + D +SH+ + I+ EA
Sbjct: 907 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 966
Query: 1679 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 1732
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 967 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 1026
Query: 1733 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 1777
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 1027 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1086
Query: 1778 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 1817
Q++ EDR ++ +D + V I + L K L
Sbjct: 1087 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1145
Query: 1818 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 1877
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 1146 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1202
Query: 1878 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 1931
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 1203 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1262
Query: 1932 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 1980
+L + + + KE ++ L W + Q R L+ L
Sbjct: 1263 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1322
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 1323 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1378
Query: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1379 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1423
Query: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
+ E L V + Q + D ++ E+
Sbjct: 1424 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1459
Query: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 2216
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1460 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1513
Query: 2217 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 2274
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1514 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1561
Query: 2275 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 2330
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1562 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1613
Query: 2331 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 2376
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1614 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1673
Query: 2377 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 2429
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1674 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1733
Query: 2430 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 2454
SE A K ++ S EE Q LN+Q
Sbjct: 1734 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1793
Query: 2455 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 2509
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1794 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1852
Query: 2510 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 2568
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 1853 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1911
Query: 2569 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 2616
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 1912 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1971
Query: 2617 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 2670
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 1972 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2029
Query: 2671 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 2728
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 2030 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2089
Query: 2729 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 2784
++KL ++ L R L ++D L W SL P S+ L
Sbjct: 2090 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2139
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 2843
+++ + E+ +S+++ ++ ++ M PS Q KD R
Sbjct: 2140 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2189
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 2903
+ S H +++ +L ++ ++ + + +KT E+D K +L
Sbjct: 2190 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2248
Query: 2904 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 2962
S LEHK E SL ++ H + A V+++ L + E +K+
Sbjct: 2249 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2306
Query: 2963 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 2999
++ F + S+ +W+ +T ++ LE ++L+ +
Sbjct: 2307 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2366
Query: 3000 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 3044
+T E+Q L L AV I ++ + + E T +++E +
Sbjct: 2367 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2426
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
+ ++ ++ ++ + LL++ L L + Q E S ++ L+ +++ +
Sbjct: 2427 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2486
Query: 3105 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 3164
+ D E ++ +Q + EL ++ +V L+D +LL E D EA
Sbjct: 2487 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2536
Query: 3165 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 3209
R K +L E+ +EL +L L+ SS+ + L W EL S +
Sbjct: 2537 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2595
Query: 3210 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 3269
P S PN T R + + + P LS PG S RG + L
Sbjct: 2596 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2653
Query: 3270 RA 3271
A
Sbjct: 2654 AA 2655
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 264 bits (675), Expect = 1e-69
Identities = 605/3391 (17%), Positives = 1312/3391 (38%), Gaps = 380/3391 (11%)
Query: 32 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 91
H+Q I Q + S + E +E+ +L+ +V GT N Q ++
Sbjct: 1754 HKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNLLETDVDGQV---GTTQENLNQQYQKVKA 1809
Query: 92 LHQTLLEESKEI---DSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRL 148
H+ ++ + + + + + EK S EK+ + + EL E + ++
Sbjct: 1810 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1869
Query: 149 QNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGR-------LSLKEQLSHRQHLLS 201
+ ++++KF+A+ + + L+Q++ L + E G LK Q S + ++S
Sbjct: 1870 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1929
Query: 202 EMESLKPKV----QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIM 257
L+ + ++ +S + V + R + A+ + +CN++
Sbjct: 1930 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1989
Query: 258 ----QAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRH--EELAQK 311
+ V +Y+ YE L + +Q +A S+H E +A
Sbjct: 1990 GNNLKDLVDKYQHYEDASCGL-----------------LAGLQACEATASKHLSEPIAVD 2032
Query: 312 IKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVM 371
K Q Q+ + ++ + ++ + V +++ AE D G LLP + +
Sbjct: 2033 PKNLQRQLEETKA------LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD 2086
Query: 372 MTAGRCHTLLSPVTEE------------SGEEGT--------NSEISSPPACRSPSPVAN 411
GR L V E S ++G N E S + P
Sbjct: 2087 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTA 2146
Query: 412 TDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETL 471
++++I Q ++ + +A ++ E +P S AK+ DL +
Sbjct: 2147 LQDIISKNIMLEQDIAGRQSSINA--MNEKVKKFMETTDPSTASSLQAKMKDLSARFSEA 2204
Query: 472 KNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALM 531
+ E + E + + +++ + + T +E L+E PG+ Q
Sbjct: 2205 SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQEST 2264
Query: 532 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMS-TIRMKASGKR- 589
E L + + E+ SL +E+ S +D A L + L+ + M TI+ K
Sbjct: 2265 SEFLEHKKHL-EVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2323
Query: 590 --------QLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPM 641
Q+L + L ++E ++ + + A++L L TK + E
Sbjct: 2324 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2383
Query: 642 DMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK-LRRLKGSL 700
+ + N++ + A++ +V + +L G+ + E A K L +K +
Sbjct: 2384 KVNNSGISLCNLISAVTTPAKAIA--AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDM 2441
Query: 701 LELQRALHDKQLNMQGTAQEKEE--SDVDLTATQSPGVQEWLAQARTTWTQQRQS----- 753
++ D L ++ E S + +S + +WL + T T+ +Q+
Sbjct: 2442 TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2501
Query: 754 ------SLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP-------- 799
++Q K E EL + + ++ + + E+L E + D E P
Sbjct: 2502 TEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL------EENPDTPEAPRWKQMLTE 2555
Query: 800 -DVLSQELGM-------EGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVL---------- 841
D QEL + E+SS E+ +++ +++L+ +VL
Sbjct: 2556 IDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNML 2615
Query: 842 --EQEQEQVL----------YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV 889
+++Q Q+L Y + G+ G+ P+ + V L + Q ++ +
Sbjct: 2616 NTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSL-RGIVKEQLAAVTQKWDSL 2674
Query: 890 SSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEIL 946
+ Q Q+I + + + S L D++ +L + A+ T NQ++
Sbjct: 2675 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV---STHPDAMNQQLE 2731
Query: 947 AKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL--SLLDSV--VNQRCHQ 1002
+ + +K + +QA E+ V E+ L L R +L S V Q+
Sbjct: 2732 TAQKMKQEIQQEKKQIKVAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAEN 2790
Query: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062
+ LQ + + + ++ +K P++ +++ ++ K+F
Sbjct: 2791 HVQHLQSACASSHQFQQMSRDF--QAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2848
Query: 1063 GIIELKRRGDKLQVEQPSMQ-------------ELSKLQDMYDELMMIIGSRRSGLNQNL 1109
+ +K E ++ +L+ ++ +D + R + L ++L
Sbjct: 2849 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2908
Query: 1110 TLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE--IQQLLDKHKEYFQGLESHMIL 1167
+Y+ ++ L ++ Q + + + ++ E I +L KE Q +L
Sbjct: 2909 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELL 2968
Query: 1168 TETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL 1225
T + + KE T + L+ + V ++ H + LE + + + E +E
Sbjct: 2969 NNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3028
Query: 1226 SRQLEVVESSIP---SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
RQL+ + + S+G + L T+ Q + SL + ++ + L++
Sbjct: 3029 KRQLQCAKEQLDIHDSLGSQAYSNKYL----TMLQTQQKSLQALKHQVDLAKRLAQDLVV 3084
Query: 1283 SIS----CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSA 1338
S SD+ Q+ + + + + ++ ++ LET L+ +Q+ ++
Sbjct: 3085 EASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3144
Query: 1339 KDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-- 1396
D L+ V ++ E ++ F K+++A + + T +L ++
Sbjct: 3145 DDELD----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3200
Query: 1397 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQK 1456
D ++ +L + Q LL A +E++ + +L + S++ + L++ +
Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT-IKRLEEFY--SKLKEFSILLQKAEEH 3257
Query: 1457 DEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESKRSD 1512
+E + + I++ L +K F+ + + KQ V+++ Q ++Q +++ ++ +
Sbjct: 3258 EESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLE 3317
Query: 1513 KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKRLKQ 1571
L +N W+ L V ++ L+ L +++ ++ L +W +T+E Q
Sbjct: 3318 -----HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ 3372
Query: 1572 QHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLREL 1631
+ + V+ +++ + L+ L+ ++ VE I++ G + + ++ L L
Sbjct: 3373 KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLL 3432
Query: 1632 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 1691
W L + L+ + + +N +L L + ++
Sbjct: 3433 DSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLE 3492
Query: 1692 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751
Q+ + L+DD+ + L + SI Q LK + + + + + W EI
Sbjct: 3493 EQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQVW---YIEI 3548
Query: 1752 AEQLQSSKALLQL--------------WQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 1797
E+ S LLQ + + S + Q+ T L K +
Sbjct: 3549 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3608
Query: 1798 IADDEVATWIQDCND-LLKGLGTVK----DSLFFLHELGEQLKQQ------VDASAASAI 1846
+ +++ Q+ + LL GL +K D + + + E +K + + A +
Sbjct: 3609 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668
Query: 1847 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 1906
+ L L++ L + + LC ++ +L YET ++L+G++ S
Sbjct: 3669 EQ-ALQLARRLHSTHEELCTWLDKVEVELLSYET----------------QVLKGEEASQ 3711
Query: 1907 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL----PLNDKE--IKRMQNLNRH 1960
+ Q R +ELK + ++ LD LNE+ L P +E K + N
Sbjct: 3712 A------QMRPKELKKEAKNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAEDNER 3762
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQ 2018
+ L+S T++ ++ + +L+ Q F + + + ++ +TE+KL +I Q
Sbjct: 3763 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3822
Query: 2019 RAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
+ + F E+ + I+ ++ G +++ +++ KL + + + + +R
Sbjct: 3823 QVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3882
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV- 2137
++ ++ E E+L WL E + + +P P + TL + + ++
Sbjct: 3883 YLQLERAQSLVNQFWETYEELWPWLTETQSI----ISQLPAPALEYETLRQQQEEHRQLR 3938
Query: 2138 -FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM---RLEEQKKKLA 2193
+ + +I + LL G E IQEK+ +A +++E KK A
Sbjct: 3939 ELIAEHKPHIDKMNKTGPQLLELSPG-------EGFSIQEKYVAADTLYSQIKEDVKKRA 3991
Query: 2194 FLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLT 2253
L + D ++++ +++ + L + AE + KE + + + D+
Sbjct: 3992 VALDEAISQSTQFHDKIDQILESLERIVERLRQP-PSISAEVEKIKEQISENKNVSVDME 4050
Query: 2254 QLSLLKDTLS-------AYISADDISI----LNERVELLQRQWEELCHQLSLRRQQIGER 2302
+L L +TL A D I + ++++ + WE + + R ++ +
Sbjct: 4051 KLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4110
Query: 2303 LNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKD----YQEEIAIAQENKI 2358
+ F + L + + + D I+ + K +++ +EEI QE
Sbjct: 4111 MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELD 4170
Query: 2359 QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ +G L A E ++ + ++N W L R+ KL+E + A Q +
Sbjct: 4171 IVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4230
Query: 2419 SSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
++ W+ +LA PI D E +++++ E ++ + + + + + + E+
Sbjct: 4231 QAVFDWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL 4287
Query: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
LL +++ ++Q L W ++ + R+ K+E +F
Sbjct: 4288 LLKKV---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4344
Query: 2537 DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT 2596
WL +E + G + EL K Q V + +E +NK L +
Sbjct: 4345 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4404
Query: 2597 DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 2656
+ A +L+ + NQRW N+ ++ ++L + Q + F + + WLT+ + L
Sbjct: 4405 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4464
Query: 2657 NIEHFSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIEEEL 2713
+ AK +QL + + K E ++ +G+Q++ + I++++
Sbjct: 4465 ASKPLGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDI 4523
Query: 2714 DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL- 2772
+ L+ + V E L++R+ +LE++ L+ + +H+ D +
Sbjct: 4524 NNLKEKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQDFIN 4563
Query: 2773 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 2832
Q L+++ L +D++ + D + ++ S + + D+
Sbjct: 4564 WLTQAEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQIIEL-DK 4611
Query: 2833 EGQDDKDFYLRGAVGLSGD-----HSALESQIRQL---GKALDDSRFQIQQ--------T 2876
G K F + V L + S E +++L G++LDD+R + +Q
Sbjct: 4612 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4671
Query: 2877 ENIIRSKTPTGPELDTS------------YKGYMKLLGECSSSIDSVKRLEHKLKEEEES 2924
E + S+ EL+ + +K + K LG S D+ R LKE+
Sbjct: 4672 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
Query: 2925 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
+ L + + + D+W+ + +++ ++ ++++ L QF L ++ WL E
Sbjct: 4732 ADDNLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4788
Query: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 3044
+L + Q + DI + I K QK + R + + ++ + E + +S +
Sbjct: 4789 PQLAEDQPVH--GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4846
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVP 3102
+ ++ +++ RW+ VC+L + L+ AL Q + FH + H LL L ++ R + ++P
Sbjct: 4847 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4906
Query: 3103 IDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
D + L D HK+ M+ +L E + + M +L K + +I
Sbjct: 4907 DDEDA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4962
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 3193
R + +L +H + L L ++Q+L
Sbjct: 4963 RARFEEVLAWAKQHQQRLASALAGLIAKQEL 4993
Score = 253 bits (647), Expect = 2e-66
Identities = 639/3471 (18%), Positives = 1341/3471 (38%), Gaps = 495/3471 (14%)
Query: 23 KKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNS 82
+K +L E Q Q +NRL L L+ Y + + WI++ + I N
Sbjct: 1302 EKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET-TQRKIQENQ 1360
Query: 83 -------ASQLREQYIL------HQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ 129
A+QL +Q +L Q+ ++E ++ + A + + T Y SQQ
Sbjct: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420
Query: 130 VAELGR------------ETEELR----QMIKIRLQNLQDAAKDMKKFEAE--------- 164
+ + R E +LR ++ + Q ++ A +K+ E E
Sbjct: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480
Query: 165 -----LKKLQAALEQAQATLTSPE-VGRLSLKEQLSHRQHLLSEMESLKPKVQAVQL--- 215
K+LQ + TL E G+ +Q + + ++ E L +Q +QL
Sbjct: 1481 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1540
Query: 216 -----------------------------CQSALRIPE-----DVVASLPLCHAALRLQE 241
+S ++ E DV + A R QE
Sbjct: 1541 KHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI--VAERQQE 1598
Query: 242 EASRLQH------------TAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKP 289
+LQ Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + +
Sbjct: 1599 YKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVV 1658
Query: 290 VATSNIQELQAQISRHEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGL 348
T N + E+L+Q+ K EQ + KC+ L +KA+ + L +
Sbjct: 1659 KNTENFLK-----ENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1713
Query: 349 AEGTEDLDGELLPTPSAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGT-NSE 396
E TE + S S V + R T V E++G +EG S
Sbjct: 1714 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSA 1773
Query: 397 ISSPPACRS-------PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQE 447
I V T ++NQ YQ + A E++ + + +T ++Q
Sbjct: 1774 IGEEDEVNGNLLETDVDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQV 1830
Query: 448 FYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAI 506
E + + + LQ++ + LK YE AL +K S+ ++E
Sbjct: 1831 LLEKQGQYLSPEEKEKLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKF 1882
Query: 507 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS------------ 554
+ +E + E ++ +A D+I L ++ Q S +E+++S
Sbjct: 1883 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISG 1941
Query: 555 -------ESCEADPAEQLALQSTLTVLAERM--STIRMKA-SGKRQLLEEKLNDQLEEQR 604
+SC ++ +T + ++ +T R ++ K +L L D +++
Sbjct: 1942 NRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK-- 1999
Query: 605 QEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVV 662
Q Y + L + L + +AT LS P +P +++ QL + + + +I + V
Sbjct: 2000 ----YQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQV 2055
Query: 663 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE 722
A+ +L E +LL+ + + L + G +L ++++++ +Q
Sbjct: 2056 AVEKLKKTAE-VLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------- 2107
Query: 723 ESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSV 775
+T T+S VQ+ L + W +SSL++Q + L+ +++ L + +
Sbjct: 2108 -----ITLTRSLSVQDGLDE-MLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 2161
Query: 776 ASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESL--HQEFSTK 833
A R I + + + + S + M+ + + E+L +E TK
Sbjct: 2162 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 2221
Query: 834 QKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQS 893
+L +N+ E+ Q + L+ V DVP +D + L+Q +E +S+
Sbjct: 2222 VELFENL--SEKLQTFLETKTQALTEV-----DVPGKD-------VTELSQYMQESTSEF 2267
Query: 894 GGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEM 953
K+ L L + +++ LP + L L+K KEM
Sbjct: 2268 LEHKKHLEVLHSLLKE-----------------ISSHGLPSDKALVLEKTNNLSKKFKEM 2310
Query: 954 SEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQIL 1011
+ + + K + E D V+ +L + + +V + + L+
Sbjct: 2311 EDTIKEKKEAVTSC-QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTK 2369
Query: 1012 NFQN--DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKR 1069
Q LK +N I L L + P A+ I A++ +G L
Sbjct: 2370 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNG 2418
Query: 1070 RGDKLQVEQ--------PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQ 1120
G E+ ++++ + Y++L +++ + + LN L+ L+ E +
Sbjct: 2419 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSA 2478
Query: 1121 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHM--------ILTETLF 1172
+ L + + Q + E ++ ++++K + L+ ++ LTE L
Sbjct: 2479 MMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLE 2538
Query: 1173 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV 1232
+ + Q TE+ ++ + + R +LE + + +L + L
Sbjct: 2539 ENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEK 2598
Query: 1233 ESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---- 1288
E + +G + + + L + Q L +P+ Q+ G+ +L S D
Sbjct: 2599 ELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLR 2657
Query: 1289 --LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
++ QL + + W S T ++S ++ + T+YQS L+ L L+
Sbjct: 2658 GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQS----LLRSLSDKLSDLDNKL 2713
Query: 1347 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELS 1406
S+ V + + L + +E+ + + L L K + L++ELS
Sbjct: 2714 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE--YLKAELS 2771
Query: 1407 RIDSQWTDLLTNIPAVQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDED 1459
R Q +L + V++K Q S H ++ +W+ +K+E
Sbjct: 2772 R---QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD-----TKKEEQ 2823
Query: 1460 NIKNSIGYK--AIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 1517
N + I K + ++ +K F + + +++ + + ++++ S+K
Sbjct: 2824 NKSHPISAKLDVLESLIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQ 2880
Query: 1518 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 1577
QL + +W V E+ L+ LE +Y+ V+ L W + + L++ D
Sbjct: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
Query: 1578 QASVQNALKDCQDLE------------------DLIKAKEKEVEKIEQNGLALIQNKKED 1619
A +N++ + L+ L+ E + E + +LIQ K +
Sbjct: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDM 2999
Query: 1620 VSSIVMS---TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYS 1676
V+ + S L + Q + + + K L+ +Q H D + S +Y
Sbjct: 3000 VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY- 3054
Query: 1677 LSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLL 1722
L+ + SL+A++ QVD + L DL + E Q+ +++ Q+
Sbjct: 3055 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3114
Query: 1723 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 1782
++C L L+ + N + E ++ + L + +D A T+Q+Q
Sbjct: 3115 EKC-----SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQ 3164
Query: 1783 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
++ LK ++D + C +L T D +
Sbjct: 3165 KETIKAFLKKLEALMASNDNAN---KTCKMMLATEETSPDLV------------------ 3203
Query: 1843 ASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
I+ D +LS+ L ++ ++ + E F L+ + +AEE + Q
Sbjct: 3204 --GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQ 3261
Query: 1903 DPSHSSDLSTIQERMEELK-GQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL---- 1957
P + TI +++ K Q + + +N LG L + + Q L
Sbjct: 3262 GPV-GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL 3320
Query: 1958 ---NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQ 2012
N W ++ + +R ++LQ LL F + E+ + ++V TE+ +A + S ++
Sbjct: 3321 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3380
Query: 2013 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 2072
+ Q + +L Q + R+ + I +G+++ + D+ + +L+LL ++W+ ++
Sbjct: 3381 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3440
Query: 2073 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 2132
+A+ R ++ Q++ E E L +WL + + PI Q ++ Q
Sbjct: 3441 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIE---KRLVNCEPIGTQASKLEEQIAQ 3497
Query: 2133 FK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASM 2183
K E + V G+ L + + + +Q++L EIQEK S S
Sbjct: 3498 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3557
Query: 2184 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEE-LHAEQMRCKELE 2242
L++ +D E + + L ++ KL S+ D+ E L +Q + L+
Sbjct: 3558 LLQQALCNAKIFGED----EVELMNWLNEVHDKLSKL--SVQDYSTEGLWKQQSELRVLQ 3611
Query: 2243 NAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGER 2302
+ ++ Q L L + D++ I+ +++E ++ +++++ + + + +
Sbjct: 3612 EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQA 3671
Query: 2303 LNEWAVFSEKNKELCEWLTQMESK-VSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQ 2361
L ++ELC WL ++E + +S +L E + + +E A+ NK L
Sbjct: 3672 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD 3731
Query: 2362 QMGE---RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ E L + +E + + N+R++ + D I +V+++ ++ QQ D+
Sbjct: 3732 SLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAA 3791
Query: 2419 SSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL 2478
+ +W+ E +L + ++ +L Q+ +I +H + ++ ++
Sbjct: 3792 DAELSWITETEKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM 3850
Query: 2479 HDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 2538
C ++ E S+++ + + + IC ++ ER L++E L +F + Y W
Sbjct: 3851 TAC----SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906
Query: 2539 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 2598
L ++ + + + Y +++ ++ + + E ++ +NK +L E
Sbjct: 3907 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGE 3965
Query: 2599 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 2658
S+++ + + +++ V L I Q +F D IL L + +L
Sbjct: 3966 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4025
Query: 2659 EHFSECDVQAKIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIE 2710
S +V+ KIK+ + + +S++ K+ E + +GE++I +S + + A ++
Sbjct: 4026 PSIS-AEVE-KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
Query: 2711 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 2770
++LD++ + + VE +RE +L D L++ W D +
Sbjct: 4084 DKLDQMVFIWENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS- 4123
Query: 2771 SLLSPQPSSNLSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAM 2823
+++ + + + L P ++ ++ +T +D + E D +L +L +A
Sbjct: 4124 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC 4183
Query: 2824 SRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIR-QLGKALDDSRFQIQQTENI--- 2879
G+ DK + L+ +L + ++ K + + +Q + +
Sbjct: 4184 ----------GEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4233
Query: 2880 ----------IRSKTPTGPELDT---SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 2926
+ S +P G +L+T + + E ++RL H+ + + +
Sbjct: 4234 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4293
Query: 2927 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 2986
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE
Sbjct: 4294 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4353
Query: 2987 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQ 3045
L ++ + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ
Sbjct: 4354 LS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ 4411
Query: 3046 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 3105
++L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 4412 NKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGG 4471
Query: 3106 ---------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 3150
N+ E+ ++ +K LMQ ++L + S + ++ +
Sbjct: 4472 LPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDIN 4524
Query: 3151 DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 3201
+ E E V N K L+E L ++ +S QD +W + E
Sbjct: 4525 NLKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4569
Score = 244 bits (624), Expect = 8e-64
Identities = 429/2257 (19%), Positives = 899/2257 (39%), Gaps = 262/2257 (11%)
Query: 37 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK----------VLAHGTIAWNSASQL 86
+Q + R +KL ++ +Y E +E + WI+K + A G + L
Sbjct: 2895 KQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSL 2954
Query: 87 REQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKI 146
+++ H ++E + L ++ E + T++ + ++ TE+L K
Sbjct: 2955 QKEMDQHFGMVELLNNTANSLLSVCE----IDKEVVTDENKSLIQKVDMVTEQLHSK-KF 3009
Query: 147 RLQNLQDAAKDMKKFEAELKK-LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMES 205
L+N+ K+ ++ E K+ LQ A EQ + + + L+ Q +++
Sbjct: 3010 CLENMTQKFKEFQEVSKESKRQLQCAKEQLD--IHDSLGSQAYSNKYLTMLQTQQKSLQA 3067
Query: 206 LKPKVQ-AVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 264
LK +V A +L Q + D + + + +E S L ++C+ ++ +
Sbjct: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3127
Query: 265 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 324
++ ++ + E++ + + LQ Q + +K++ + N
Sbjct: 3128 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3187
Query: 325 KCKMLTMKAKHATMLLTV-TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSP 383
CKM+ + + L+ + ++E L++ +LL A V T R S
Sbjct: 3188 TCKMMLATEETSPDLVGIKRDLEALSKQC----NKLLDRAQAREEQVEGTIKRLEEFYSK 3243
Query: 384 VTE-----ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 438
+ E + EE S+ PV ++NQ + ++ E ++ K
Sbjct: 3244 LKEFSILLQKAEEHEESQ----------GPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3293
Query: 439 HPSTSASQEFYEPGLEPSATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
Q + + ++T L D+ W+TL ++++ L EAL ++QD
Sbjct: 3294 QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQD 3353
Query: 495 SLQS-ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELV 553
+L+S +S ++ EL ++ P P ++ +A + E +LQ +++ +S++ E++
Sbjct: 3354 ALESLLSWMVDTEELVANQKP-----PSAEFKVVKAQIQEQKLLQRLLDDRKSTV--EVI 3406
Query: 554 SESCE-----ADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE-------------EK 595
E A+PA+++ + L++L R + KA + + LE E
Sbjct: 3407 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3466
Query: 596 LNDQLE--EQR---------QEQALQRYRCEADELDSWLLSTKATLDTALS--------P 636
LN+ L E+R Q L+ + L+ +++ L A+S
Sbjct: 3467 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLS 3526
Query: 637 PKEPMDMEAQLMD-CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE------QL 689
+E DM +D Q +EI++K + SEL + L K +DE E ++
Sbjct: 3527 SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL---QQALCNAKIFGEDEVELMNWLNEV 3583
Query: 690 AGKLRRL-------------KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGV 736
KL +L + L LQ + ++ N+ E T + +
Sbjct: 3584 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3643
Query: 737 QEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAG 796
Q+ L + + + S K LEQ L L R + S EE+ E
Sbjct: 3644 QDKLEAIKARYKDITKLSTDVAKTLEQAL----QLARRLHSTHEELCTWLDKVEV----- 3694
Query: 797 EKPDVLSQELG-MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 855
++LS E ++GE++S Q +M+ + L +E + LL + L + +L P R
Sbjct: 3695 ---ELLSYETQVLKGEEAS---QAQMRPKELKKEAKNNKALLDS-LNEVSSALLELVPWR 3747
Query: 856 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 915
G+ + +D + D + Q EE+ + +I Q+ A
Sbjct: 3748 AREGLE----KMVAEDNERYRLVSDTITQKVEEIDA--------AILRSQQFDQAADAEL 3795
Query: 916 TWLDDVEERLFVATALLPEETETC-------LFNQEILAKDIKEMSEEMDKNKNLFSQAF 968
+W+ + E++L + E+ +T F EIL K++ +++ K+ + A
Sbjct: 3796 SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH--KDIIDDLVKSGHKIMTAC 3853
Query: 969 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN-FQNDLKVLFTSLADN 1027
E + + ++ L +L + + ++R Q+ ER Q ++N F + L+ L +
Sbjct: 3854 SE--EEKQSMKKKLDKVLKNYDTICQINSERYLQL-ERAQSLVNQFWETYEELWPWLTET 3910
Query: 1028 KYIILQKLANVFE-QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP----SMQ 1082
+ II Q A E + + +Q E +Q + + E I ++ + G +L P S+Q
Sbjct: 3911 QSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQ 3970
Query: 1083 ELSKLQD-MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 1141
E D +Y ++ + R L++ ++ +Q+ + + + LE E++ I
Sbjct: 3971 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSIS 4029
Query: 1142 SSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRA 1201
+ E+I++ + ++K +E L ETL Q E++A++ K
Sbjct: 4030 AEVEKIKEQISENKNVSVDMEKLQPLYETL------------KQRGEEMIARSGGTDKDI 4077
Query: 1202 HKRGVE--LEYILETWSHL----DEDQQELSRQLEVVE-------SSIPSV----GLVEE 1244
+ V+ L+ ++ W ++ +E + +L +E+ E S I ++ + +
Sbjct: 4078 SAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD 4137
Query: 1245 NEDRLIDRITLYQH------LKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQ 1295
ED ID + Q ++ ++ Q +L V++ G L+ + D ++ +++
Sbjct: 4138 LEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDE 4197
Query: 1296 LGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQE 1355
L W S + +LE ++ +YQ + W+ A +L + + +
Sbjct: 4198 LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----PIGTD 4253
Query: 1356 LEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV----DTATLRSELSRIDSQ 1411
LE V+ + +F E Q ++ L+ +LL LKKV D T++ L +
Sbjct: 4254 LETVKQQIEELKQFKSEA-YQQQIEMERLNHQAELL-LKKVTEESDKHTVQDPLMELKLI 4311
Query: 1412 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--YKA 1469
W L I Q KL + +HA+ E+++W++ E ++ + + +G KA
Sbjct: 4312 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-----QKPVGGDPKA 4366
Query: 1470 IHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK-TDFAEQLGAMNKSWQ 1528
I L K+ + D+ Q TV+ VN++ + +ES ++ ++ +L +N+ WQ
Sbjct: 4367 IEIELAKHHVLQNDVLAHQSTVEAVNKA----GNDLIESSAGEEASNLQNKLEVLNQRWQ 4422
Query: 1529 ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNALKD 1587
+ ++ Q L+G L + ++ L+ W E+ L +G + + L
Sbjct: 4423 NVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4482
Query: 1588 CQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKI 1647
++ +AKE+ + + Q G ++ + + + + L + W +++ + + K
Sbjct: 4483 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4542
Query: 1648 LLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 1707
L+ L+ + ++L +A +L+ + L+ V Q+D + +++
Sbjct: 4543 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4602
Query: 1708 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS-------SKA 1760
+ + L + N L V RW +++ + E+ +S +K
Sbjct: 4603 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4662
Query: 1761 LLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTV 1820
+ W + ++ ++ ++ + + N+ D++ T + + K LG
Sbjct: 4663 FHEAWSKLMEWLEESEKSLDSELEIAND-----------PDKIKTQLAQHKEFQKSLGAK 4711
Query: 1821 KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE---QALC----KQQTSLQA 1873
+ G LK++ +++ D L L L L +C ++Q L+
Sbjct: 4712 HSVYDTTNRTGRSLKEK------TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4765
Query: 1874 GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 1933
+L F +L+AL W+ E L P H D+ + ++ K +
Sbjct: 4766 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSS 4824
Query: 1934 LDRLNELGYRLPLNDKEIK-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 1988
+ L L ++ +MQ L+ W + + + + ++L++ L Q + F
Sbjct: 4825 VQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV 4884
Query: 1989 CETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL 2046
+E+L + EQ L + + L H+ F ++ ++ L+ G +L
Sbjct: 4885 VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4944
Query: 2047 EQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV-E 2105
D +T++ +++ V+ A+Q + + S + +E+ E L WL
Sbjct: 4945 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 5004
Query: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQ-FKEKVFLRQ 2141
+ L +P +++ + L E Q F E++ +Q
Sbjct: 5005 ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5041
Score = 230 bits (587), Expect = 2e-59
Identities = 557/3213 (17%), Positives = 1245/3213 (38%), Gaps = 497/3213 (15%)
Query: 264 YEQYEQEMKHLQQLIEGAH----REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQI 319
Y Y E+++++ +E R+I P+ ++ E +I+ E+L ++++ ++ +
Sbjct: 1105 YNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDLHESVFRITEQEKLKKELERLKDDL 1163
Query: 320 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 379
++ +KC+ +A ++ + PT + +VV+ + ++
Sbjct: 1164 GTITNKCEEFFSQAAASSSV---------------------PTLRSELNVVLQNMNQVYS 1202
Query: 380 LLSP----------VTEESGEEGTNSEISSPPACRSPSPVANTDASVN--QDIAYYQALS 427
+ S V + + ++ C + +A+ + N + +++
Sbjct: 1203 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV 1262
Query: 428 AERLQTDAA---KIHPSTSASQEFYEPGLEPSAT-----AKLGDLQRSWETLKNVISEKQ 479
E+ Q A ++ + + S E ++ E K L W+ + I +
Sbjct: 1263 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1322
Query: 480 RTLYEALERQQKYQDSLQSISTKMEAIEL---KLSES-PEPGRSPESQMAEHQALMDEIL 535
R L + + Y+D+ + ++ +E K+ E+ PE ++ +Q+ + + L+ EI
Sbjct: 1323 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1382
Query: 536 MLQDEINELQS---------------SLAEELVSESCEADPAEQLALQSTLTVLAERMST 580
M Q +++E Q ++ + +S + P ++ +QS+ ++ +
Sbjct: 1383 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1442
Query: 581 IRMKASGKRQLLEEKLN---DQLEE-QRQEQALQRYRCE----ADELDSWLLSTKATLDT 632
+R + + L+ + + D L+ + +E++L+ + E A EL W+ + TL
Sbjct: 1443 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1502
Query: 633 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 692
A K P Q + + + + EQ AL + + L G T +E +L +
Sbjct: 1503 AEKAGKPP--FSKQKISSEEISTKKEQLSEALQTIQLF---LAKHGDKMTDEERNELEKQ 1557
Query: 693 LRRLKGS----LLELQRALHDKQLNMQGTAQEKEESDVD-------------LTATQSPG 735
++ L+ S E + L + Q + +EK ++ LT T++
Sbjct: 1558 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1617
Query: 736 VQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 795
+ A T + + +Q+EL++++ L V E L ++
Sbjct: 1618 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN--------- 1668
Query: 796 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQ--KLLQNVLEQEQEQVLYSRP 853
GEK LSQE E+ E +++ + +L E S K+ K++ +++E E+V +
Sbjct: 1669 GEK---LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1725
Query: 854 NRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSA 913
+ K+ + +LLD L+ + S+ G K + + +
Sbjct: 1726 LE--------------ESKTKIENLLDWLSNV--DKDSERAGTKHKQV---------IEQ 1760
Query: 914 TSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD 973
T + + + + + EE E N +L D+ + +NL Q
Sbjct: 1761 NGTHFQEGDGK-----SAIGEEDEV---NGNLLETDVD--GQVGTTQENLNQQYQKVKAQ 1810
Query: 974 NRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLF-TSLADNKYIIL 1032
+ +I ++ S + Q + E +++ +LKV + T+LA+++
Sbjct: 1811 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESE---- 1866
Query: 1033 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 1092
++++ ++ L++FDA E + LQ + ++ L D +
Sbjct: 1867 ------------KKMKLTHSLQEELEKFDADYTEFEH---WLQQSEQELENLEAGADDIN 1911
Query: 1093 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQ--EKMAGDQKIIVSSKEEIQQL 1150
LM + ++S ++ K +LE + K G + ++ E+Q+
Sbjct: 1912 GLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRK 1971
Query: 1151 LDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEY 1210
LD + F+ L S + + ++ Q L+A A A K
Sbjct: 1972 LDHATDRFRSLYSKCNVLGNNLKDLVD-KYQHYEDASCGLLAGLQACEATASK------- 2023
Query: 1211 ILETWSHLDE----DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 1266
HL E D + L RQLE ++ + + ++L + + SL
Sbjct: 2024 ------HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPA 2077
Query: 1267 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 1326
+ + + LDD I DL +N+ E +L+ L Q
Sbjct: 2078 KNDIQKTLDD-----IVGRYEDLSKSVNERNE--------------KLQITLTRSLSVQD 2118
Query: 1327 ESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
+++ W+ + + L ++ VP ++D ++ + +++ + S ++
Sbjct: 2119 GLDEMLDWMGNVESSL----KEQGQVPLNSTALQDIISKNIMLEQDIAG----RQSSINA 2170
Query: 1387 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 1446
N+ ++KK T S S + ++ DL K H+ + K+ E+ +
Sbjct: 2171 MNE--KVKKFMETTDPSTASSLQAKMKDLSARFSEASHK-HKETLAKM------EELKTK 2221
Query: 1447 ISLMENVIQKDEDNIKN--------SIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ L EN+ +K + ++ + K + E Q + + + ++ ++ +
Sbjct: 2222 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 2281
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 1558
+ISS + SDK E+ ++K ++ ++ + EK + + E ++ V+ L
Sbjct: 2282 KEISSHGLP---SDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2338
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL------ 1612
K+W + K++ + +L+D + L++ K E++K+ +G++L
Sbjct: 2339 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2398
Query: 1613 IQNKKEDVSSIVM--------STLRELGQTWAN------------LDHMVGQLKILLKSV 1652
+ + ++++ T + WAN + H L +LLK
Sbjct: 2399 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2458
Query: 1653 LDQWSSHKVAFDK-------INSYLMEARYSLSRFRLLTG--SLEAVQVQVDNLQNLQDD 1703
+ + ++ K + +L + + ++++ EAV+ QV+ ++ + +
Sbjct: 2459 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2518
Query: 1704 LEKQERSLQKFGSITNQLLKE-CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALL 1762
L++ +Q+ +LL+E P L E++ +W L + ++ Q +
Sbjct: 2519 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2578
Query: 1763 QLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKD 1822
+++ Q + ++E + L + + ++ + T Q LL+ T K
Sbjct: 2579 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN----TQRQQVQILLQEFATRKP 2634
Query: 1823 SLFFLHELGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYET 1880
L G+ + + D S ++ +++Q +L L + + ++
Sbjct: 2635 QYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ 2694
Query: 1881 FAKSLEALEAWIVEAEEILQG------QDPSHSSDLSTIQERMEEL---KGQMLKFSSMA 1931
+ L +L + + + L + + L T Q+ +E+ K Q+ ++
Sbjct: 2695 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC 2754
Query: 1932 PDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL---QHQTFLEK 1988
DL L + Y L + ++++ + + + + + LQS Q Q
Sbjct: 2755 EDLSALVKEEY---LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2811
Query: 1989 CETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ 2048
+ W++ + EQ + IS L + H+ F + ++ + I +G+ LL +
Sbjct: 2812 FQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2870
Query: 2049 GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKW------ 2102
Q ++ L+L + W ++ ++R + + + +Y+E E L W
Sbjct: 2871 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2930
Query: 2103 -LVEVSYL--PMSG-----------------LGSVPIPLQQARTLFDEVQFKEKVFLRQQ 2142
L E+ + P G G V + A +L + ++V +
Sbjct: 2931 NLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN 2990
Query: 2143 GSYILTVE------------------------------------AGKQLLLSADSGAEAA 2166
S I V+ A +QL + G++A
Sbjct: 2991 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3050
Query: 2167 LQAELAEIQEKWKS--ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK---LS 2221
L +Q + KS A + K+LA L KG +D L ++ T ++ LS
Sbjct: 3051 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3110
Query: 2222 QSLPDHHEELHAE-------QMRCKELENAVGSWTDDLTQLSLL----------KDTLSA 2264
Q + + L + Q +E+ + + D+L ++ + K+T+ A
Sbjct: 3111 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3170
Query: 2265 YI-------------------------SADDISILNERVELLQRQWEELCHQLSLRRQQI 2299
++ ++ D+ + +E L +Q +L + R +Q+
Sbjct: 3171 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3230
Query: 2300 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQ 2354
+ F K KE L + E G + I + + K +EEI Q
Sbjct: 3231 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3290
Query: 2355 ENKIQLQQMGERLAKASHESKASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ 2413
+ + +G+ L +++ +S +++ +E+ L VN RW+ L +A R +L+E L+ +
Sbjct: 3291 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3350
Query: 2414 LDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
+ SL +W+ E +A KP S + ++ ++ EQ+ LQR ++ + V
Sbjct: 3351 FQDALESLLSWMVDTEELVANQKP---PSAEFKVVKAQIQEQKLLQRLLDDRKSTV---- 3403
Query: 2472 NLCEVLLHDCDACATDAE-CDSIQ--QATRNLDRRWRNICAMSMERRLKIEETWRLWQKF 2528
EV+ + + AT AE D ++ + LD RW + + R ++E + Q+F
Sbjct: 3404 ---EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3460
Query: 2529 LDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV---HECLTQLELINK 2585
+ +WL + E+ G + +E++ + +A + + ++ L Q I +
Sbjct: 3461 HETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ 3520
Query: 2586 QYRRLARENRTDSACSLKQMVHEGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSI 2644
+ L+ D + Q + +Q W +Q++ S L+ + + F +
Sbjct: 3521 SLKVLSSREDKD----MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVEL 3576
Query: 2645 LVWLTEMDLQLT--NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 2702
+ WL E+ +L+ +++ +S + + +L+ Q++I L ++Q + G +L++++
Sbjct: 3577 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTT 3636
Query: 2703 PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDL 2762
+ II+++L+ ++ +++ L D ++ L+L + L
Sbjct: 3637 GDEVLIIQDKLEAIKARYKDI-------------TKLSTDVAKTLEQALQL--ARRLHST 3681
Query: 2763 H-----WHDRSADSLLSPQ----PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 2813
H W D+ LLS + S + +P ++ ++ A +DS+
Sbjct: 3682 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL-------- 3733
Query: 2814 DLSRDLESAMSRALPSEDEEG-----QDDKDFYLRGAVGLSGDHSALESQI---RQLGKA 2865
++ SA+ +P EG +D + Y + ++ +++ I +Q +A
Sbjct: 3734 ---NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3790
Query: 2866 LDDSRFQIQQTENIIRS-------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
D I +TE + S + T +L M++L ID + + HK+
Sbjct: 3791 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDLVKSGHKI 3849
Query: 2919 ----KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLN 2974
EEE+ S + + V+ ++ + + L++++ QF
Sbjct: 3850 MTACSEEEK--------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3901
Query: 2975 SIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFT 3034
+W WL +T+ + QL L + +T+ Q ++ ++L++ + K I +N P+
Sbjct: 3902 ELWPWLTETQSIISQLPAPAL--EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3959
Query: 3035 QADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 3094
+ E +Q++ + + ++ +++ L +A+ Q FH+ +L LE I
Sbjct: 3960 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4019
Query: 3095 RRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE 3154
R + P + + E +++ + + ++ + Q +L+ +++ + GTD
Sbjct: 4020 ERLRQ--PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI 4077
Query: 3155 AKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDV 3186
+ + V +++ + + + ++E E KLLDV
Sbjct: 4078 SAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4110
Score = 210 bits (534), Expect = 2e-53
Identities = 462/2514 (18%), Positives = 971/2514 (38%), Gaps = 299/2514 (11%)
Query: 21 LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 80
L++++ + + + ++AEN + L A + ++ +M W++ K
Sbjct: 2770 LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQ 2823
Query: 81 NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEEL 140
N + + + + ++L+++ K+ L A + ++ E + + G E L
Sbjct: 2824 NKSHPISAKLDVLESLIKDHKDFSKTLTAQS----HMYEKTIAEGENLLLKTQGSEKAAL 2879
Query: 141 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLL 200
+ + N K +K+ E KL+ +LE+A L KEQ+ + L
Sbjct: 2880 QLQLNTIKTNWDTFNKQVKERE---NKLKESLEKA-----------LKYKEQV---ETLW 2922
Query: 201 SEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------ 254
++ + ++ ++ C E+ +A L LQ+E QH + +
Sbjct: 2923 PWIDKCQNNLEEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTAN 2973
Query: 255 NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEE 307
+++ + E E K L Q ++ ++ K N+ QE+ + R +
Sbjct: 2974 SLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ 3033
Query: 308 LAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLA--------------EGTE 353
A++ + + S K LTM L + LA +GT
Sbjct: 3034 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTS 3093
Query: 354 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSP 408
D+ ++ H ++ +C L + + + T E+ S A S +P
Sbjct: 3094 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3153
Query: 409 VANTDASVNQD----IAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL 464
V ++ + A+ + L A D A + E P L L L
Sbjct: 3154 VGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL-VGIKRDLEAL 3212
Query: 465 QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---E 521
+ L + ++ + ++R +++ L+ S I L+ +E E + P E
Sbjct: 3213 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGME 3267
Query: 522 SQMAEHQALMDEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLA 575
++ Q M ++ ++EI LQ L + L+ + ++ + L+ L +
Sbjct: 3268 TETINQQLNMFKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVN 3324
Query: 576 ERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALS 635
R T+ K + + L+E L L R + AL + L SW++ T+ +
Sbjct: 3325 ARWKTLNKKVAQRAAQLQEAL---LHCGRFQDAL-------ESLLSWMVDTEELVANQKP 3374
Query: 636 PPKEPMDMEAQ---------LMDCQNMLVEI--------------EQKVVALSELSVHNE 672
P E ++AQ L+D + VE+ KV L +LS+ +
Sbjct: 3375 PSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3434
Query: 673 NL-LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLT 729
L KA T++ R+L+G + Q+ H+ + LN T EK + +
Sbjct: 3435 RWEALLNKAETRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPI 3484
Query: 730 ATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA- 788
TQ+ ++E +AQ + + K L Q ++ +S L+ ++SR ++ ++Q
Sbjct: 3485 GTQASKLEEQIAQHKAL----EDDIINHNKHLHQAVSIGQS-LKVLSSREDKDMVQSKLD 3539
Query: 789 ------AETSGDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFST 832
E + + ++L Q L K ED++ M W +H Q++ST
Sbjct: 3540 FSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST 3597
Query: 833 KQK-LLQNVLEQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEE 888
+ Q+ L QE +L + N LL+G+ L K + + L+ + +++
Sbjct: 3598 EGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKD 3656
Query: 889 VSSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQ 943
++ S + Q++ L ++L+ TWLD VE L + L EE
Sbjct: 3657 ITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP 3716
Query: 944 EILAKDIKEMSEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVV 996
+ L K+ K +D + N S A E G + V ED R L+ +
Sbjct: 3717 KELKKEAKNNKALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTI 3770
Query: 997 NQRCHQMKERLQQILNFQN--DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAE 1054
Q+ ++ + + F D ++ + + + K + L + +Q A+
Sbjct: 3771 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3830
Query: 1055 DGLKEFDAGIIELKRRGDKL------QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN 1108
+ L+ D I +L + G K+ + +Q ++L K+ YD + I R L +
Sbjct: 3831 EILRHKDI-IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERA 3889
Query: 1109 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILT 1168
+L +Q+ ++L L T + + E ++Q ++H++ + + H
Sbjct: 3890 QSLVNQFWETYEELWPWL-TETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 3948
Query: 1169 ETLFR---KII------SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLD 1219
+ + + +++ F++Q++ L +Q +K KR V L+ + +
Sbjct: 3949 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK---KRAVALDEAISQSTQFH 4005
Query: 1220 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 1279
+ ++ LE + + + +++ ++I+ +++ + + QP LY+ L
Sbjct: 4006 DKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQP-LYETLKQRGE 4064
Query: 1280 LLIS--------ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 1331
+I+ IS ++ +L+Q+ W + + + +L +++ ++ + L
Sbjct: 4065 EMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4124
Query: 1332 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 1391
I ++ +D + + + +V+ A +E+D V++ G++L+
Sbjct: 4125 IVTIKDTQDFIRDLEDPGI----DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4180
Query: 1392 -RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM 1450
+ D ++ + ++S W L +KL + + + + V W+ +
Sbjct: 4181 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4240
Query: 1451 ENVIQKDEDNIKNSIG--YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 1508
+ + IG + + + +++ K FK + +Q+ ++ +N + + E
Sbjct: 4241 GGKLAS-----MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE- 4294
Query: 1509 KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 1568
SDK + L + W L+ + + LEG L + ++++ + L W E
Sbjct: 4295 -ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4353
Query: 1569 LKQQHRI-GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 1627
L +Q + GD +++ L L++ + A + VE + + G LI++ + +S + +
Sbjct: 4354 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4413
Query: 1628 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSL 1687
L L Q W N+ Q K L L Q + + +L + L + L G
Sbjct: 4414 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4473
Query: 1688 EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNL 1747
E + Q++ + E +E + + Q+L C + + + +W ++
Sbjct: 4474 ETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4533
Query: 1748 LEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWI 1807
++ E+ + L L + + + + + Q E + L A+ + D V I
Sbjct: 4534 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE----QTLNVASRPSLILDTVLFQI 4589
Query: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
+ + + ++ + L + G LK I++ +S+ + Q L ++
Sbjct: 4590 DEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4649
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
SL + F ++ L W+ E+E+ L + ++D I+ ++ + K
Sbjct: 4650 GRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD-SELEIANDPDKIKTQLAQHKEFQKSL 4708
Query: 1928 SSMAPDLDRLNELGYRL----PLNDKEIK---RMQNLNRHWSLISSQTTERFSKLQSFLL 1980
+ D N G L L D +K + L W I ++ ER +KL+ LL
Sbjct: 4709 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSI 2038
F + + +++L + E +LA + + G+ ++ H+ FQ E+ R + ++
Sbjct: 4769 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL 4828
Query: 2039 IIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
+ L+E G DD +++ LS +W+ V + ++ +++ +RQ + + +
Sbjct: 4829 KRSARELIE-GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4887
Query: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158
L +WL E + G +P RTL D+ + K ++ G +L
Sbjct: 4888 LLEWLAEAEQ-TLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI 4946
Query: 2159 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF----LLKDWEKCEKGIADSLEKLR 2214
+ ++ + I+ +++ ++ +++LA L+ E E +A
Sbjct: 4947 CHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAET 5006
Query: 2215 TFKKKLSQSLPDHHEELHA---------EQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
T K + +P EE+ A E+M K+ + V T + + +L ++
Sbjct: 5007 TLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPD--VDKVTKTYKRRAADPSSLQSH 5064
Query: 2266 I----------------------SADDISILNERVELLQRQWEELCHQLSLRRQQIG--- 2300
I S I N RV LL +W+++ RR+++
Sbjct: 5065 IPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDAL 5124
Query: 2301 ---ERLNEWAVFSEK--NKELCEWLTQMESKV---------SQNGDILIEEMIE 2340
E L E+A F K+ W+ +S+V Q+G I +E I+
Sbjct: 5125 DRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFID 5178
Score = 203 bits (516), Expect = 3e-51
Identities = 501/2642 (18%), Positives = 1024/2642 (38%), Gaps = 403/2642 (15%)
Query: 2 ELDAAVQKFLEQNGQLGKP---LAKKIGKLTELHQQTIRQAENRLSKLNQAAS------- 51
+L A QK+ GQL + + I K T+ +Q +R ++LS L+ S
Sbjct: 2663 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ-YQSLLRSLSDKLSDLDNKLSSSLAVST 2721
Query: 52 HLEEYNEMLELILKWI-----EKAKVLAHGTIAWNSASQLREQYILHQT------LLEES 100
H + N+ LE K EK ++ + + ++ ++E+Y+ + +L+
Sbjct: 2722 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSF 2781
Query: 101 KEIDSELEAMTEKLQYLTSVYCTEKMSQQVA-------ELGRETEELRQMIKIRLQNLQD 153
K+++ + E +Q+L S + QQ++ + +E + I +L L+
Sbjct: 2782 KDVEQKAE---NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLES 2838
Query: 154 AAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV 213
KD K F K L A + T+ E L LK Q S + L ++ ++K
Sbjct: 2839 LIKDHKDFS---KTLTAQSHMYEKTIAEGE--NLLLKTQGSEKAALQLQLNTIKTNWDTF 2893
Query: 214 ------------QLCQSALRIPEDVVASLPL---CHAALR-------------------- 238
+ + AL+ E V P C L
Sbjct: 2894 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2953
Query: 239 LQEEASRLQHTAIQQC------NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVAT 292
LQ+E QH + + +++ + E E K L Q ++ ++ K
Sbjct: 2954 LQKEMD--QHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3011
Query: 293 SNI-------QELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 345
N+ QE+ + R + A++ + + S K LTM L +
Sbjct: 3012 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071
Query: 346 EGLAE--------------GTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEE 391
LA+ GT D+ ++ H ++ +C L + + +
Sbjct: 3072 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3131
Query: 392 GTNSEISSPPA-----CRSPSPVANTDASVNQDI----AYYQALSAERLQTDAAKIHPST 442
T E+ S A S +PV ++ + A+ + L A D A
Sbjct: 3132 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 3191
Query: 443 SASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTK 502
+ E P L L L + L + ++ + ++R +++ L+ S
Sbjct: 3192 MLATEETSPDLV-GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS-- 3248
Query: 503 MEAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSS------LAEELV 553
I L+ +E E + P E++ Q M ++ ++EI LQ L + L+
Sbjct: 3249 ---ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ-KEEIEPLQGKQQDVNWLGQGLI 3304
Query: 554 SESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYR 613
+ ++ + L+ L + R T+ K + + L+E L L R + AL+
Sbjct: 3305 QSAAKSTSTQ--GLEHDLDDVNARWKTLNKKVAQRAAQLQEAL---LHCGRFQDALE--- 3356
Query: 614 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQ---------LMDCQNMLVEI------- 657
L SW++ T+ + P E ++AQ L+D + VE+
Sbjct: 3357 ----SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3412
Query: 658 -------EQKVVALSELSVHNENL-LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD 709
KV L +LS+ + L KA T++ R+L+G + Q+ H+
Sbjct: 3413 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRN---------RQLEGISVVAQQ-FHE 3462
Query: 710 --KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 767
+ LN T EK + + TQ+ ++E +AQ + + K L Q ++
Sbjct: 3463 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKAL----EDDIINHNKHLHQAVSI 3518
Query: 768 QKSLLRSVASRGEEILIQHSA-------AETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 820
+SL + ++SR ++ ++Q E + + ++L Q L K ED++
Sbjct: 3519 GQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVE 3575
Query: 821 -MKW-ESLH--------QEFSTKQKLLQ-NVLEQEQEQVLYSRPN---RLLSGVPLYKGD 866
M W +H Q++ST+ Q + L QE +L + N LL+G+ L K
Sbjct: 3576 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLK-Q 3634
Query: 867 VPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEE 923
+ + L+ + +++++ S + Q++ L ++L+ TWLD VE
Sbjct: 3635 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3694
Query: 924 RL--FVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPE-------NGDN 974
L + L EE + L K+ K +D + N S A E G
Sbjct: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD-SLNEVSSALLELVPWRAREGLE 3753
Query: 975 RDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 1034
+ V ED R L+ + Q+ ++ + +
Sbjct: 3754 KMVAEDN-----ERYRLVSDTITQKVEEIDAAILR------------------------- 3783
Query: 1035 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 1094
+ F+Q ++ I + E L +E + +LQV++ E+ + +D+ D+L
Sbjct: 3784 -SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3842
Query: 1095 MMIIGSRRSGLNQN--LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 1152
+ + ++ ++K + ++ L++ + + E+ E Q L++
Sbjct: 3843 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYL--------QLERAQSLVN 3894
Query: 1153 KHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYIL 1212
+ E ++ L LTET + IIS +L A A LEY
Sbjct: 3895 QFWETYEELWPW--LTET--QSIIS-----------QLPAPA-------------LEY-- 3924
Query: 1213 ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQ 1272
ET QQE RQL L+ E++ + +N+ P+L +
Sbjct: 3925 ETL----RQQQEEHRQLRE---------LIAEHKPHI-----------DKMNKTGPQLLE 3960
Query: 1273 VLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLI 1332
L G+ I ++ +Q+ E + K L+ + T++ + ++
Sbjct: 3961 -LSPGEGFSIQEKYVAADTLYSQIKE-------DVKKRAVALDEAISQSTQFHDKIDQIL 4012
Query: 1333 HWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR 1392
L+ +RL +Q ++ E+E +++ ++ S +++ L ++ G +++
Sbjct: 4013 ESLERIVERL----RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 4068
Query: 1393 L-----KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 1447
K + ++ +L ++ W ++ T + + KL L + +L + MS I
Sbjct: 4069 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKL--LDVMELAEKFWCDH-MSLI 4125
Query: 1448 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVE 1507
+++ D I + + + + + +I+ Q +D V + + S+ +
Sbjct: 4126 VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIV----INLGSELIA 4181
Query: 1508 S-KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 1566
+ DK + + +N +W L ++I LE +++ +Y++ +Q + W +
Sbjct: 4182 ACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 4241
Query: 1567 KRLKQQHRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSS-IV 1624
+L IG D +V+ +++ + + ++ E+E++ L++ E+ V
Sbjct: 4242 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTV 4301
Query: 1625 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLT 1684
L EL W +L+ + + L+ L + A D++ ++L LS + +
Sbjct: 4302 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4361
Query: 1685 GSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRW 1744
G +A+++++ LQ+D+ + +++ N L++ L N L+ +N RW
Sbjct: 4362 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4421
Query: 1745 NNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN---KDIADD 1801
N+LE+ ++ Q L+ + K + + Q D LL + + A +
Sbjct: 4422 QNVLEKTEQRKQQLDGALR---QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKE 4478
Query: 1802 EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE 1861
++ ++ C T K L + G+Q+ + SA + I D +L + ++E
Sbjct: 4479 QLNVHMEVCAAFEAKEETYKS----LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4534
Query: 1862 QALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELK 1921
L +++T L+ + F SL+ W+ +AE+ L S L T+ +++E K
Sbjct: 4535 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP-SLILDTVLFQIDEHK 4593
Query: 1922 GQMLKFSSMAPDLDRLNELGYRLPL--NDKEIKRMQNL----NRHWSLISSQTTERFSKL 1975
+ +S + L++ G L +++ ++NL W + + ER L
Sbjct: 4594 VFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL 4653
Query: 1976 QSFLLQHQTFLEKCETWMEFLVQTEQKL--AVEISGNYQHLLEQQRAHELFQAEMFSRQQ 2033
+ + F E ME+L ++E+ L +EI+ + + Q H+ FQ + ++
Sbjct: 4654 DDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHS 4713
Query: 2034 ILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRY 2092
+ + G+ L E+ + DD + + L+ L ++W + ++ +R+ ++ + ++
Sbjct: 4714 VYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4773
Query: 2093 REMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAG 2152
+ + L WL V ++ V + L D K F ++ G +V+A
Sbjct: 4774 TDALQALIDWLYRVEP-QLAEDQPVHGDIDLVMNLIDN----HKAFQKELGKRTSSVQAL 4828
Query: 2153 KQL---LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADS 2209
K+ L+ + ++ ++ E+ +W++ ++ +L L+ E+ +
Sbjct: 4829 KRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL 4888
Query: 2210 LEKLRTFKKKLSQS--LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS 2267
LE L ++ L LPD + L + KE + +L + + + DT+ A
Sbjct: 4889 LEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICH 4948
Query: 2268 ADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV 2327
D I+ + + +++ ++EE+ +Q++ L E + L WL E+ +
Sbjct: 4949 PDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTL 5008
Query: 2328 SQNGDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAK-----ASH---- 2372
+ +I + IE++K + + EE+ Q + ++ + +R A SH
Sbjct: 5009 TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVL 5068
Query: 2373 -----------------ESKASEIEYKLGKVN---DRWQHLLDLIAARVKKLKETLVAVQ 2412
++IE K +VN +WQ + L R +KL + L ++
Sbjct: 5069 DKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLE 5128
Query: 2413 QL 2414
+L
Sbjct: 5129 EL 5130
Score = 182 bits (462), Expect = 5e-45
Identities = 617/3357 (18%), Positives = 1313/3357 (39%), Gaps = 415/3357 (12%)
Query: 28 LTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLR 87
L L IR+ + S L+Q + E + ++ +L W+++ +V T W S
Sbjct: 616 LQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT-EWGSDLPSV 674
Query: 88 EQYIL-HQTLLEESKEIDSEL-EAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIK 145
E ++ H+ + +E +S L EA ++Q + T ++++ L + +L +
Sbjct: 675 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT--YAEKLHRLESQYAKLLNTSR 732
Query: 146 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMES 205
+ ++L + + EL L E+ A S ++ K+ + L+ E++
Sbjct: 733 NQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKD--YHAELMRELDQ 790
Query: 206 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ-- 263
+ +++VQ L + E+ A L + +Q + S + +Q C ++ + +
Sbjct: 791 KEENIKSVQEIAEQLLL-ENHPARLTIEAYRAAMQTQWSWI----LQLCQCVEQHIKENT 845
Query: 264 -YEQYEQEMKHLQQLIEGAHREIEDKPVA--TSNIQELQAQISRHEELAQKIKGYQEQIA 320
Y ++ + K + I+ K +S+I +L+ + E +++ Y+ IA
Sbjct: 846 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 905
Query: 321 SLNSKCK-MLTMKAKHATM-LLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 378
+L K K ++ +K +++ L T ++ + + + + + + A H
Sbjct: 906 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI-------EITIYKDDECVLANNSH 958
Query: 379 TLLSPVTEESGEEGTNSEI--SSPPACRSPSPVANTDASVNQDIAYY---------QALS 427
V +G E + + PP + +AN Q++ +S
Sbjct: 959 RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 1018
Query: 428 AERLQTDAAKIHPSTSAS----------------QEFYEPGLEPSATAKL--GDLQRSWE 469
L + +I S AS Q +E LE S +++ G E
Sbjct: 1019 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1078
Query: 470 TLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPE----PGRSP----- 520
NV + + L ++ ER+++ + +++ I L+L + R+P
Sbjct: 1079 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1138
Query: 521 --ES--QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 576
ES ++ E + L E+ L+D++ + + EE S++ + L+S L V+ +
Sbjct: 1139 LHESVFRITEQEKLKKELERLKDDLGTITNK-CEEFFSQAAASSSVP--TLRSELNVVLQ 1195
Query: 577 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 636
M+ + +S L+ Q E ++ Y + E ++ +++ K ++ +S
Sbjct: 1196 NMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA-VIADKNNIENLIST 1254
Query: 637 PKEPMDMEAQLMDCQNMLVEIEQKVVALS-ELSVHNENLLLEGKAHTKDEAEQLAGKLRR 695
K+ + + L + QK A+S E+ + L+ H K++A+QL + R
Sbjct: 1255 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH-KEKADQL---VER 1310
Query: 696 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSL 755
+ +++ L D ++G + + T P + +W+ Q TT + +++
Sbjct: 1311 WQNVHVQIDNRLRD----LEGIGKSLKY----YRDTYHP-LDDWIQQVETTQRKIQENQP 1361
Query: 756 QQQKELEQELAEQKSLLRSVASRGEEI-LIQHSAAETSGDAGE-KPDVLSQELGMEGEKS 813
+ K L +L +QK L+ + + ++ Q A + S + + ++ ++ ++
Sbjct: 1362 ENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1421
Query: 814 SAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS 873
S + RM+ S+ ++Q ++ L +R L++ + Y K
Sbjct: 1422 SPVKRRRMQ--------SSADLIIQEFMD------LRTRYTALVTLMTQY-------IKF 1460
Query: 874 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLP 933
A SL + EE K++ + ++L VS S L D E+ A P
Sbjct: 1461 AGDSL-----KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK------AGKP 1509
Query: 934 EETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 993
++ + ++EI K KE E + LF ++GD + D
Sbjct: 1510 PFSKQKISSEEISTK--KEQLSEALQTIQLF---LAKHGD----------------KMTD 1548
Query: 994 SVVNQRCHQMKERLQQILN--FQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQ 1051
N+ Q+K LQ+ N F LK L S + +K+ +Q E+++ I
Sbjct: 1549 EERNELEKQVK-TLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGIC 1607
Query: 1052 QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111
+ G E GD EL K Q +EL + L +
Sbjct: 1608 DLLTQTENRLIGHQEAFMIGD-------GTVELKKYQSKQEELQKDMQGSAQALAE---- 1656
Query: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 1171
+++ + L+ EK++ + K + I+Q L++ K + L ++
Sbjct: 1657 ------VVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLNLKAEQSKKE 1704
Query: 1172 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL-SRQLE 1230
K+++ A+++ET + A +K+ + ++E +L+ S++D+D + ++ +
Sbjct: 1705 LDKVVTTAIKEET--------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQ 1756
Query: 1231 VVESS---------IPSVGLVEENEDRLIDRI------TLYQHLKSSLNEYQPKLYQVLD 1275
V+E + ++G +E L++ T ++L + + + +++
Sbjct: 1757 VIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIIS 1816
Query: 1276 DGKRLLISISCSD--LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIH 1333
+ ++I+ + LE Q L K+ K + L+ + + L H
Sbjct: 1817 QHQAVIIATQSAQVLLEKQGQYLSP---EEKEKLQKNMKELKVHYETALAESEKKMKLTH 1873
Query: 1334 WLQSAKDR-------LEFWTQQSVTVPQELEMVRDHLNAFL-------EFSKEVDAQSSL 1379
LQ ++ E W QQS + LE D +N + FS++V +
Sbjct: 1874 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1933
Query: 1380 KSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 1439
+ +GN++L K S+ D D VQ KL D+ S ++
Sbjct: 1934 LRYITISGNRVLEAAK--------SCSKRDGGKVDTSATHREVQRKLDH-ATDRFRSLYS 1984
Query: 1440 ISEVM--SWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQS 1497
V+ + L++ ++ + G +A K+ I ++ K L
Sbjct: 1985 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2044
Query: 1498 VL--QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 1555
L QISSQ V ++ KT AE L S + + + + + G E S+ N
Sbjct: 2045 ALQGQISSQQVAVEKLKKT--AEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN-- 2100
Query: 1556 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 1615
E+ K Q + SVQ+ L + D +++ KE ++ N AL
Sbjct: 2101 ----------ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL--- 2147
Query: 1616 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV-LDQWSSHKVAFDKINSYLMEAR 1674
+D+ S + +++ ++++ M ++K +++ SS + +++ EA
Sbjct: 2148 --QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEAS 2205
Query: 1675 YSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP---VTE 1731
+ + + +E ++ +V+ +NL + LQ F Q L E P VTE
Sbjct: 2206 H---KHKETLAKMEELKTKVELFENLSE-------KLQTFLETKTQALTEVDVPGKDVTE 2255
Query: 1732 TLTNTLKEVNMRW----------NNLLEEIAEQ-LQSSKAL-LQLWQRYKDYSKQCASTV 1779
L+ ++E + ++LL+EI+ L S KAL L+ K+ T+
Sbjct: 2256 -LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTI 2314
Query: 1780 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 1839
+++++ + + + +WI++ K + V+ S F +LG+ L+
Sbjct: 2315 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETT---KKVPIVQPS-FGAEDLGKSLEDTKK 2370
Query: 1840 ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL 1899
++++ ++ Q + SL + T AK++ A+++ +L
Sbjct: 2371 LQEKWSLKTPEI----------QKVNNSGISLCNLISAVTTPAKAIAAVKS----GGAVL 2416
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNR 1959
G+ + +++ + + +K M S DL L L DK + LN
Sbjct: 2417 NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLL--------LKDK----IAELNT 2464
Query: 1960 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQR 2019
S + E + +Q ++T W + T+ + AV+ +EQ +
Sbjct: 2465 KLSKLQKAQEESSAMMQWLQKMNKT----ATKWQQTPAPTDTE-AVKTQ------VEQNK 2513
Query: 2020 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
+ E + ++ Q L + + L E + + LT + ++WQ + + R+
Sbjct: 2514 SFEAELKQNVNKVQELKDKLT--ELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2571
Query: 2080 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 2139
++ +++ + +L++WLVE L +S LG + I T +VQ + F
Sbjct: 2572 QKLEESSNNLTQFQTVEAQLKQWLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2630
Query: 2140 RQQGSYILTVEAGKQLLL--SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 2197
++ Y AG+ +L D ++ +LA + +KW S + +L ++ + +
Sbjct: 2631 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2690
Query: 2198 DWEKCEKGIADSLEKLRTFKKKLSQSL--PDHHEELHAEQMRCKELENAVGSWTDDLTQL 2255
+ + + +KL KLS SL H + ++ + ++++ + +
Sbjct: 2691 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2750
Query: 2256 SLLKDTLSAYISADDISI-LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK 2314
L + LSA + + + L+ ++E + + ++++ + Q + F + ++
Sbjct: 2751 QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSR 2810
Query: 2315 ELCEWLTQMESKVSQNGDILIE-EMIEKLKKDYQE--EIAIAQENKIQLQ-QMGERLAKA 2370
+ WL + + +++ I + +++E L KD+++ + AQ + + GE L
Sbjct: 2811 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2870
Query: 2371 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 2430
+ S+ + ++ +L + W + R KLKE+L + + + +L W+ ++
Sbjct: 2871 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2930
Query: 2431 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD---ACATD 2487
L + + + E + + + + LQ+++++H V + N LL C+ TD
Sbjct: 2931 NLEE--IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2988
Query: 2488 AECDSIQQATRNLDR-RWRNICAMSMERRLK-IEETWRLWQKFLDDYSRFEDWLKSSERT 2545
IQ+ ++ + C +M ++ K +E + ++ L D + S +
Sbjct: 2989 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD-IHDSLGS 3047
Query: 2546 AAFPSSSGVIYTVAKEELKKFEAFQRQV--------------------HECLTQLELINK 2585
A+ S T+ + + K +A + QV + L Q+E I +
Sbjct: 3048 QAY---SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQ 3104
Query: 2586 QYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSIL 2645
++ L+++ D CS + +G + N ++ Q EF+ DS
Sbjct: 3105 EHSTLSQQ--VDEKCSFLETKLQGIGHFQN----------TIREMFSQFAEFDDELDS-- 3150
Query: 2646 VWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 2705
+ + ++ E ++A +K+L+A + + ++A E++ P D
Sbjct: 3151 --MAPVGRDAETLQKQKE-TIKAFLKKLEALMASNDNANKTCKMMLA-----TEETSP-D 3201
Query: 2706 AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 2765
I+ +L+ L + C ++ R + +++ +E +E S L H
Sbjct: 3202 LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF----SILLQKAEEH 3257
Query: 2766 DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR 2825
+ S + + N L++ + + E P + W L + L + ++
Sbjct: 3258 EESQGPVGMETETINQQLNMFKVFQKEEI---EPLQGKQQDVNW-----LGQGLIQSAAK 3309
Query: 2826 ALPSED-EEGQDDKDFYLRGAVGLSGDHSA-LESQIRQLGK---ALDDSRFQIQQTENII 2880
+ ++ E DD + + +A L+ + G+ AL+ + TE ++
Sbjct: 3310 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3369
Query: 2881 RSKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST 2934
++ P E K +LL + S+++ +KR K+ E L
Sbjct: 3370 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL--- 3426
Query: 2935 ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE 2994
Q + + RWE L +A ++ +++ QQF+ L + WL E+ L +
Sbjct: 3427 -KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE--P 3483
Query: 2995 LSTDIQTIELQIKKLKELQ-KAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQMN 3052
+ T +E QI + K L+ ++H K + ++++ S+E +D+ Q +L
Sbjct: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQ 3542
Query: 3053 GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL 3112
+ + LLQ AL + F E L+ L + + +++ D E L
Sbjct: 3543 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD--YSTEGL 3600
Query: 3113 QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKE 3172
+L ++ ++L + V +LL G + L ++K+ I R K + K
Sbjct: 3601 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3660
Query: 3173 VSRHIKELEKLLDVS----SSQQDLSSWSSADELD-TSGSVSPTSGRSTPNRQKTPR 3224
+ K LE+ L ++ S+ ++L +W E++ S G Q P+
Sbjct: 3661 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3717
Score = 96.3 bits (238), Expect = 5e-19
Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)
Query: 1330 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 650 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 702
Query: 1387 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 1446
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 703 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 754
Query: 1447 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 1506
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 755 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 806
Query: 1507 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 1565
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 807 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 864
Query: 1566 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 1623
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 865 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 917
Query: 1624 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 1678
+T + + +I + D +SH+ + I+ EA
Sbjct: 918 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 977
Query: 1679 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 1732
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 978 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 1037
Query: 1733 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 1777
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 1038 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1097
Query: 1778 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 1817
Q++ EDR ++ +D + V I + L K L
Sbjct: 1098 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1156
Query: 1818 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 1877
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 1157 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1213
Query: 1878 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 1931
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 1214 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1273
Query: 1932 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 1980
+L + + + KE ++ L W + Q R L+ L
Sbjct: 1274 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1333
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 1334 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1389
Query: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1390 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1434
Query: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
+ E L V + Q + D ++ E+
Sbjct: 1435 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1470
Query: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 2216
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1471 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1524
Query: 2217 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 2274
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1525 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1572
Query: 2275 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 2330
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1573 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1624
Query: 2331 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 2376
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1625 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1684
Query: 2377 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 2429
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1685 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1744
Query: 2430 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 2454
SE A K ++ S EE Q LN+Q
Sbjct: 1745 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1804
Query: 2455 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 2509
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1805 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1863
Query: 2510 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 2568
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 1864 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1922
Query: 2569 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 2616
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 1923 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1982
Query: 2617 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 2670
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 1983 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2040
Query: 2671 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 2728
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 2041 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2100
Query: 2729 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 2784
++KL ++ L R L ++D L W SL P S+ L
Sbjct: 2101 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2150
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 2843
+++ + E+ +S+++ ++ ++ M PS Q KD R
Sbjct: 2151 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2200
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 2903
+ S H +++ +L ++ ++ + + +KT E+D K +L
Sbjct: 2201 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2259
Query: 2904 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 2962
S LEHK E SL ++ H + A V+++ L + E +K+
Sbjct: 2260 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2317
Query: 2963 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 2999
++ F + S+ +W+ +T ++ LE ++L+ +
Sbjct: 2318 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2377
Query: 3000 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 3044
+T E+Q L L AV I ++ + + E T +++E +
Sbjct: 2378 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
+ ++ ++ ++ + LL++ L L + Q E S ++ L+ +++ +
Sbjct: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497
Query: 3105 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 3164
+ D E ++ +Q + EL ++ +V L+D +LL E D EA
Sbjct: 2498 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2547
Query: 3165 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 3209
R K +L E+ +EL +L L+ SS+ + L W EL S +
Sbjct: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2606
Query: 3210 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 3269
P S PN T R + + + P LS PG S RG + L
Sbjct: 2607 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2664
Query: 3270 RA 3271
A
Sbjct: 2665 AA 2666
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 264 bits (675), Expect = 1e-69
Identities = 605/3391 (17%), Positives = 1312/3391 (38%), Gaps = 380/3391 (11%)
Query: 32 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 91
H+Q I Q + S + E +E+ +L+ +V GT N Q ++
Sbjct: 1892 HKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNLLETDVDGQV---GTTQENLNQQYQKVKA 1947
Query: 92 LHQTLLEESKEI---DSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRL 148
H+ ++ + + + + + EK S EK+ + + EL E + ++
Sbjct: 1948 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 2007
Query: 149 QNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGR-------LSLKEQLSHRQHLLS 201
+ ++++KF+A+ + + L+Q++ L + E G LK Q S + ++S
Sbjct: 2008 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 2067
Query: 202 EMESLKPKV----QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIM 257
L+ + ++ +S + V + R + A+ + +CN++
Sbjct: 2068 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 2127
Query: 258 ----QAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRH--EELAQK 311
+ V +Y+ YE L + +Q +A S+H E +A
Sbjct: 2128 GNNLKDLVDKYQHYEDASCGL-----------------LAGLQACEATASKHLSEPIAVD 2170
Query: 312 IKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVM 371
K Q Q+ + ++ + ++ + V +++ AE D G LLP + +
Sbjct: 2171 PKNLQRQLEETKA------LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD 2224
Query: 372 MTAGRCHTLLSPVTEE------------SGEEGT--------NSEISSPPACRSPSPVAN 411
GR L V E S ++G N E S + P
Sbjct: 2225 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTA 2284
Query: 412 TDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETL 471
++++I Q ++ + +A ++ E +P S AK+ DL +
Sbjct: 2285 LQDIISKNIMLEQDIAGRQSSINA--MNEKVKKFMETTDPSTASSLQAKMKDLSARFSEA 2342
Query: 472 KNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALM 531
+ E + E + + +++ + + T +E L+E PG+ Q
Sbjct: 2343 SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQEST 2402
Query: 532 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMS-TIRMKASGKR- 589
E L + + E+ SL +E+ S +D A L + L+ + M TI+ K
Sbjct: 2403 SEFLEHKKHL-EVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2461
Query: 590 --------QLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPM 641
Q+L + L ++E ++ + + A++L L TK + E
Sbjct: 2462 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2521
Query: 642 DMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK-LRRLKGSL 700
+ + N++ + A++ +V + +L G+ + E A K L +K +
Sbjct: 2522 KVNNSGISLCNLISAVTTPAKAIA--AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDM 2579
Query: 701 LELQRALHDKQLNMQGTAQEKEE--SDVDLTATQSPGVQEWLAQARTTWTQQRQS----- 753
++ D L ++ E S + +S + +WL + T T+ +Q+
Sbjct: 2580 TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2639
Query: 754 ------SLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP-------- 799
++Q K E EL + + ++ + + E+L E + D E P
Sbjct: 2640 TEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL------EENPDTPEAPRWKQMLTE 2693
Query: 800 -DVLSQELGM-------EGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVL---------- 841
D QEL + E+SS E+ +++ +++L+ +VL
Sbjct: 2694 IDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNML 2753
Query: 842 --EQEQEQVL----------YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV 889
+++Q Q+L Y + G+ G+ P+ + V L + Q ++ +
Sbjct: 2754 NTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSL-RGIVKEQLAAVTQKWDSL 2812
Query: 890 SSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEIL 946
+ Q Q+I + + + S L D++ +L + A+ T NQ++
Sbjct: 2813 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV---STHPDAMNQQLE 2869
Query: 947 AKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL--SLLDSV--VNQRCHQ 1002
+ + +K + +QA E+ V E+ L L R +L S V Q+
Sbjct: 2870 TAQKMKQEIQQEKKQIKVAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAEN 2928
Query: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062
+ LQ + + + ++ +K P++ +++ ++ K+F
Sbjct: 2929 HVQHLQSACASSHQFQQMSRDF--QAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2986
Query: 1063 GIIELKRRGDKLQVEQPSMQ-------------ELSKLQDMYDELMMIIGSRRSGLNQNL 1109
+ +K E ++ +L+ ++ +D + R + L ++L
Sbjct: 2987 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 3046
Query: 1110 TLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE--IQQLLDKHKEYFQGLESHMIL 1167
+Y+ ++ L ++ Q + + + ++ E I +L KE Q +L
Sbjct: 3047 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELL 3106
Query: 1168 TETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL 1225
T + + KE T + L+ + V ++ H + LE + + + E +E
Sbjct: 3107 NNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3166
Query: 1226 SRQLEVVESSIP---SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
RQL+ + + S+G + L T+ Q + SL + ++ + L++
Sbjct: 3167 KRQLQCAKEQLDIHDSLGSQAYSNKYL----TMLQTQQKSLQALKHQVDLAKRLAQDLVV 3222
Query: 1283 SIS----CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSA 1338
S SD+ Q+ + + + + ++ ++ LET L+ +Q+ ++
Sbjct: 3223 EASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3282
Query: 1339 KDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-- 1396
D L+ V ++ E ++ F K+++A + + T +L ++
Sbjct: 3283 DDELD----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3338
Query: 1397 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQK 1456
D ++ +L + Q LL A +E++ + +L + S++ + L++ +
Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT-IKRLEEFY--SKLKEFSILLQKAEEH 3395
Query: 1457 DEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESKRSD 1512
+E + + I++ L +K F+ + + KQ V+++ Q ++Q +++ ++ +
Sbjct: 3396 EESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLE 3455
Query: 1513 KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKRLKQ 1571
L +N W+ L V ++ L+ L +++ ++ L +W +T+E Q
Sbjct: 3456 -----HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ 3510
Query: 1572 QHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLREL 1631
+ + V+ +++ + L+ L+ ++ VE I++ G + + ++ L L
Sbjct: 3511 KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLL 3570
Query: 1632 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 1691
W L + L+ + + +N +L L + ++
Sbjct: 3571 DSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLE 3630
Query: 1692 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751
Q+ + L+DD+ + L + SI Q LK + + + + + W EI
Sbjct: 3631 EQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQVW---YIEI 3686
Query: 1752 AEQLQSSKALLQL--------------WQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 1797
E+ S LLQ + + S + Q+ T L K +
Sbjct: 3687 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3746
Query: 1798 IADDEVATWIQDCND-LLKGLGTVK----DSLFFLHELGEQLKQQ------VDASAASAI 1846
+ +++ Q+ + LL GL +K D + + + E +K + + A +
Sbjct: 3747 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3806
Query: 1847 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 1906
+ L L++ L + + LC ++ +L YET ++L+G++ S
Sbjct: 3807 EQ-ALQLARRLHSTHEELCTWLDKVEVELLSYET----------------QVLKGEEASQ 3849
Query: 1907 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL----PLNDKE--IKRMQNLNRH 1960
+ Q R +ELK + ++ LD LNE+ L P +E K + N
Sbjct: 3850 A------QMRPKELKKEAKNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAEDNER 3900
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQ 2018
+ L+S T++ ++ + +L+ Q F + + + ++ +TE+KL +I Q
Sbjct: 3901 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3960
Query: 2019 RAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
+ + F E+ + I+ ++ G +++ +++ KL + + + + +R
Sbjct: 3961 QVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 4020
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV- 2137
++ ++ E E+L WL E + + +P P + TL + + ++
Sbjct: 4021 YLQLERAQSLVNQFWETYEELWPWLTETQSI----ISQLPAPALEYETLRQQQEEHRQLR 4076
Query: 2138 -FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM---RLEEQKKKLA 2193
+ + +I + LL G E IQEK+ +A +++E KK A
Sbjct: 4077 ELIAEHKPHIDKMNKTGPQLLELSPG-------EGFSIQEKYVAADTLYSQIKEDVKKRA 4129
Query: 2194 FLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLT 2253
L + D ++++ +++ + L + AE + KE + + + D+
Sbjct: 4130 VALDEAISQSTQFHDKIDQILESLERIVERLRQP-PSISAEVEKIKEQISENKNVSVDME 4188
Query: 2254 QLSLLKDTLS-------AYISADDISI----LNERVELLQRQWEELCHQLSLRRQQIGER 2302
+L L +TL A D I + ++++ + WE + + R ++ +
Sbjct: 4189 KLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4248
Query: 2303 LNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKD----YQEEIAIAQENKI 2358
+ F + L + + + D I+ + K +++ +EEI QE
Sbjct: 4249 MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELD 4308
Query: 2359 QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ +G L A E ++ + ++N W L R+ KL+E + A Q +
Sbjct: 4309 IVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4368
Query: 2419 SSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
++ W+ +LA PI D E +++++ E ++ + + + + + + E+
Sbjct: 4369 QAVFDWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL 4425
Query: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
LL +++ ++Q L W ++ + R+ K+E +F
Sbjct: 4426 LLKKV---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4482
Query: 2537 DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT 2596
WL +E + G + EL K Q V + +E +NK L +
Sbjct: 4483 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4542
Query: 2597 DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 2656
+ A +L+ + NQRW N+ ++ ++L + Q + F + + WLT+ + L
Sbjct: 4543 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4602
Query: 2657 NIEHFSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIEEEL 2713
+ AK +QL + + K E ++ +G+Q++ + I++++
Sbjct: 4603 ASKPLGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDI 4661
Query: 2714 DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL- 2772
+ L+ + V E L++R+ +LE++ L+ + +H+ D +
Sbjct: 4662 NNLKEKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQDFIN 4701
Query: 2773 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 2832
Q L+++ L +D++ + D + ++ S + + D+
Sbjct: 4702 WLTQAEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQIIEL-DK 4749
Query: 2833 EGQDDKDFYLRGAVGLSGD-----HSALESQIRQL---GKALDDSRFQIQQ--------T 2876
G K F + V L + S E +++L G++LDD+R + +Q
Sbjct: 4750 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4809
Query: 2877 ENIIRSKTPTGPELDTS------------YKGYMKLLGECSSSIDSVKRLEHKLKEEEES 2924
E + S+ EL+ + +K + K LG S D+ R LKE+
Sbjct: 4810 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4869
Query: 2925 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
+ L + + + D+W+ + +++ ++ ++++ L QF L ++ WL E
Sbjct: 4870 ADDNLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4926
Query: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 3044
+L + Q + DI + I K QK + R + + ++ + E + +S +
Sbjct: 4927 PQLAEDQPVH--GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4984
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVP 3102
+ ++ +++ RW+ VC+L + L+ AL Q + FH + H LL L ++ R + ++P
Sbjct: 4985 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 5044
Query: 3103 IDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
D + L D HK+ M+ +L E + + M +L K + +I
Sbjct: 5045 DDEDA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 5100
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 3193
R + +L +H + L L ++Q+L
Sbjct: 5101 RARFEEVLAWAKQHQQRLASALAGLIAKQEL 5131
Score = 253 bits (647), Expect = 2e-66
Identities = 639/3471 (18%), Positives = 1341/3471 (38%), Gaps = 495/3471 (14%)
Query: 23 KKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNS 82
+K +L E Q Q +NRL L L+ Y + + WI++ + I N
Sbjct: 1440 EKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET-TQRKIQENQ 1498
Query: 83 -------ASQLREQYIL------HQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ 129
A+QL +Q +L Q+ ++E ++ + A + + T Y SQQ
Sbjct: 1499 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1558
Query: 130 VAELGR------------ETEELR----QMIKIRLQNLQDAAKDMKKFEAE--------- 164
+ + R E +LR ++ + Q ++ A +K+ E E
Sbjct: 1559 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1618
Query: 165 -----LKKLQAALEQAQATLTSPE-VGRLSLKEQLSHRQHLLSEMESLKPKVQAVQL--- 215
K+LQ + TL E G+ +Q + + ++ E L +Q +QL
Sbjct: 1619 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1678
Query: 216 -----------------------------CQSALRIPE-----DVVASLPLCHAALRLQE 241
+S ++ E DV + A R QE
Sbjct: 1679 KHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI--VAERQQE 1736
Query: 242 EASRLQH------------TAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKP 289
+LQ Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + +
Sbjct: 1737 YKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVV 1796
Query: 290 VATSNIQELQAQISRHEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGL 348
T N + E+L+Q+ K EQ + KC+ L +KA+ + L +
Sbjct: 1797 KNTENFLK-----ENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1851
Query: 349 AEGTEDLDGELLPTPSAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGT-NSE 396
E TE + S S V + R T V E++G +EG S
Sbjct: 1852 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSA 1911
Query: 397 ISSPPACRS-------PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQE 447
I V T ++NQ YQ + A E++ + + +T ++Q
Sbjct: 1912 IGEEDEVNGNLLETDVDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQV 1968
Query: 448 FYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAI 506
E + + + LQ++ + LK YE AL +K S+ ++E
Sbjct: 1969 LLEKQGQYLSPEEKEKLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKF 2020
Query: 507 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS------------ 554
+ +E + E ++ +A D+I L ++ Q S +E+++S
Sbjct: 2021 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISG 2079
Query: 555 -------ESCEADPAEQLALQSTLTVLAERM--STIRMKA-SGKRQLLEEKLNDQLEEQR 604
+SC ++ +T + ++ +T R ++ K +L L D +++
Sbjct: 2080 NRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK-- 2137
Query: 605 QEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVV 662
Q Y + L + L + +AT LS P +P +++ QL + + + +I + V
Sbjct: 2138 ----YQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQV 2193
Query: 663 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE 722
A+ +L E +LL+ + + L + G +L ++++++ +Q
Sbjct: 2194 AVEKLKKTAE-VLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------- 2245
Query: 723 ESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSV 775
+T T+S VQ+ L + W +SSL++Q + L+ +++ L + +
Sbjct: 2246 -----ITLTRSLSVQDGLDE-MLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 2299
Query: 776 ASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESL--HQEFSTK 833
A R I + + + + S + M+ + + E+L +E TK
Sbjct: 2300 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 2359
Query: 834 QKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQS 893
+L +N+ E+ Q + L+ V DVP +D + L+Q +E +S+
Sbjct: 2360 VELFENL--SEKLQTFLETKTQALTEV-----DVPGKD-------VTELSQYMQESTSEF 2405
Query: 894 GGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEM 953
K+ L L + +++ LP + L L+K KEM
Sbjct: 2406 LEHKKHLEVLHSLLKE-----------------ISSHGLPSDKALVLEKTNNLSKKFKEM 2448
Query: 954 SEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQIL 1011
+ + + K + E D V+ +L + + +V + + L+
Sbjct: 2449 EDTIKEKKEAVTSC-QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTK 2507
Query: 1012 NFQN--DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKR 1069
Q LK +N I L L + P A+ I A++ +G L
Sbjct: 2508 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNG 2556
Query: 1070 RGDKLQVEQ--------PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQ 1120
G E+ ++++ + Y++L +++ + + LN L+ L+ E +
Sbjct: 2557 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSA 2616
Query: 1121 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHM--------ILTETLF 1172
+ L + + Q + E ++ ++++K + L+ ++ LTE L
Sbjct: 2617 MMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLE 2676
Query: 1173 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV 1232
+ + Q TE+ ++ + + R +LE + + +L + L
Sbjct: 2677 ENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEK 2736
Query: 1233 ESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---- 1288
E + +G + + + L + Q L +P+ Q+ G+ +L S D
Sbjct: 2737 ELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLR 2795
Query: 1289 --LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
++ QL + + W S T ++S ++ + T+YQS L+ L L+
Sbjct: 2796 GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQS----LLRSLSDKLSDLDNKL 2851
Query: 1347 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELS 1406
S+ V + + L + +E+ + + L L K + L++ELS
Sbjct: 2852 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE--YLKAELS 2909
Query: 1407 RIDSQWTDLLTNIPAVQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDED 1459
R Q +L + V++K Q S H ++ +W+ +K+E
Sbjct: 2910 R---QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD-----TKKEEQ 2961
Query: 1460 NIKNSIGYK--AIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 1517
N + I K + ++ +K F + + +++ + + ++++ S+K
Sbjct: 2962 NKSHPISAKLDVLESLIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQ 3018
Query: 1518 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 1577
QL + +W V E+ L+ LE +Y+ V+ L W + + L++ D
Sbjct: 3019 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 3078
Query: 1578 QASVQNALKDCQDLE------------------DLIKAKEKEVEKIEQNGLALIQNKKED 1619
A +N++ + L+ L+ E + E + +LIQ K +
Sbjct: 3079 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDM 3137
Query: 1620 VSSIVMS---TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYS 1676
V+ + S L + Q + + + K L+ +Q H D + S +Y
Sbjct: 3138 VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY- 3192
Query: 1677 LSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLL 1722
L+ + SL+A++ QVD + L DL + E Q+ +++ Q+
Sbjct: 3193 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3252
Query: 1723 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 1782
++C L L+ + N + E ++ + L + +D A T+Q+Q
Sbjct: 3253 EKC-----SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQ 3302
Query: 1783 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
++ LK ++D + C +L T D +
Sbjct: 3303 KETIKAFLKKLEALMASNDNAN---KTCKMMLATEETSPDLV------------------ 3341
Query: 1843 ASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
I+ D +LS+ L ++ ++ + E F L+ + +AEE + Q
Sbjct: 3342 --GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQ 3399
Query: 1903 DPSHSSDLSTIQERMEELK-GQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL---- 1957
P + TI +++ K Q + + +N LG L + + Q L
Sbjct: 3400 GPV-GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL 3458
Query: 1958 ---NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQ 2012
N W ++ + +R ++LQ LL F + E+ + ++V TE+ +A + S ++
Sbjct: 3459 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3518
Query: 2013 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 2072
+ Q + +L Q + R+ + I +G+++ + D+ + +L+LL ++W+ ++
Sbjct: 3519 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3578
Query: 2073 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 2132
+A+ R ++ Q++ E E L +WL + + PI Q ++ Q
Sbjct: 3579 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIE---KRLVNCEPIGTQASKLEEQIAQ 3635
Query: 2133 FK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASM 2183
K E + V G+ L + + + +Q++L EIQEK S S
Sbjct: 3636 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3695
Query: 2184 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEE-LHAEQMRCKELE 2242
L++ +D E + + L ++ KL S+ D+ E L +Q + L+
Sbjct: 3696 LLQQALCNAKIFGED----EVELMNWLNEVHDKLSKL--SVQDYSTEGLWKQQSELRVLQ 3749
Query: 2243 NAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGER 2302
+ ++ Q L L + D++ I+ +++E ++ +++++ + + + +
Sbjct: 3750 EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQA 3809
Query: 2303 LNEWAVFSEKNKELCEWLTQMESK-VSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQ 2361
L ++ELC WL ++E + +S +L E + + +E A+ NK L
Sbjct: 3810 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD 3869
Query: 2362 QMGE---RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ E L + +E + + N+R++ + D I +V+++ ++ QQ D+
Sbjct: 3870 SLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAA 3929
Query: 2419 SSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL 2478
+ +W+ E +L + ++ +L Q+ +I +H + ++ ++
Sbjct: 3930 DAELSWITETEKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM 3988
Query: 2479 HDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 2538
C ++ E S+++ + + + IC ++ ER L++E L +F + Y W
Sbjct: 3989 TAC----SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 4044
Query: 2539 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 2598
L ++ + + + Y +++ ++ + + E ++ +NK +L E
Sbjct: 4045 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGE 4103
Query: 2599 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 2658
S+++ + + +++ V L I Q +F D IL L + +L
Sbjct: 4104 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4163
Query: 2659 EHFSECDVQAKIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIE 2710
S +V+ KIK+ + + +S++ K+ E + +GE++I +S + + A ++
Sbjct: 4164 PSIS-AEVE-KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4221
Query: 2711 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 2770
++LD++ + + VE +RE +L D L++ W D +
Sbjct: 4222 DKLDQMVFIWENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS- 4261
Query: 2771 SLLSPQPSSNLSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAM 2823
+++ + + + L P ++ ++ +T +D + E D +L +L +A
Sbjct: 4262 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC 4321
Query: 2824 SRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIR-QLGKALDDSRFQIQQTENI--- 2879
G+ DK + L+ +L + ++ K + + +Q + +
Sbjct: 4322 ----------GEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4371
Query: 2880 ----------IRSKTPTGPELDT---SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 2926
+ S +P G +L+T + + E ++RL H+ + + +
Sbjct: 4372 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4431
Query: 2927 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 2986
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE
Sbjct: 4432 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4491
Query: 2987 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQ 3045
L ++ + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ
Sbjct: 4492 LS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ 4549
Query: 3046 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 3105
++L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 4550 NKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGG 4609
Query: 3106 ---------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 3150
N+ E+ ++ +K LMQ ++L + S + ++ +
Sbjct: 4610 LPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDIN 4662
Query: 3151 DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 3201
+ E E V N K L+E L ++ +S QD +W + E
Sbjct: 4663 NLKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4707
Score = 244 bits (624), Expect = 8e-64
Identities = 429/2257 (19%), Positives = 899/2257 (39%), Gaps = 262/2257 (11%)
Query: 37 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK----------VLAHGTIAWNSASQL 86
+Q + R +KL ++ +Y E +E + WI+K + A G + L
Sbjct: 3033 KQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSL 3092
Query: 87 REQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKI 146
+++ H ++E + L ++ E + T++ + ++ TE+L K
Sbjct: 3093 QKEMDQHFGMVELLNNTANSLLSVCE----IDKEVVTDENKSLIQKVDMVTEQLHSK-KF 3147
Query: 147 RLQNLQDAAKDMKKFEAELKK-LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMES 205
L+N+ K+ ++ E K+ LQ A EQ + + + L+ Q +++
Sbjct: 3148 CLENMTQKFKEFQEVSKESKRQLQCAKEQLD--IHDSLGSQAYSNKYLTMLQTQQKSLQA 3205
Query: 206 LKPKVQ-AVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 264
LK +V A +L Q + D + + + +E S L ++C+ ++ +
Sbjct: 3206 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3265
Query: 265 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 324
++ ++ + E++ + + LQ Q + +K++ + N
Sbjct: 3266 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3325
Query: 325 KCKMLTMKAKHATMLLTV-TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSP 383
CKM+ + + L+ + ++E L++ +LL A V T R S
Sbjct: 3326 TCKMMLATEETSPDLVGIKRDLEALSKQC----NKLLDRAQAREEQVEGTIKRLEEFYSK 3381
Query: 384 VTE-----ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 438
+ E + EE S+ PV ++NQ + ++ E ++ K
Sbjct: 3382 LKEFSILLQKAEEHEESQ----------GPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3431
Query: 439 HPSTSASQEFYEPGLEPSATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
Q + + ++T L D+ W+TL ++++ L EAL ++QD
Sbjct: 3432 QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQD 3491
Query: 495 SLQS-ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELV 553
+L+S +S ++ EL ++ P P ++ +A + E +LQ +++ +S++ E++
Sbjct: 3492 ALESLLSWMVDTEELVANQKP-----PSAEFKVVKAQIQEQKLLQRLLDDRKSTV--EVI 3544
Query: 554 SESCE-----ADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE-------------EK 595
E A+PA+++ + L++L R + KA + + LE E
Sbjct: 3545 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3604
Query: 596 LNDQLE--EQR---------QEQALQRYRCEADELDSWLLSTKATLDTALS--------P 636
LN+ L E+R Q L+ + L+ +++ L A+S
Sbjct: 3605 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLS 3664
Query: 637 PKEPMDMEAQLMD-CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE------QL 689
+E DM +D Q +EI++K + SEL + L K +DE E ++
Sbjct: 3665 SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL---QQALCNAKIFGEDEVELMNWLNEV 3721
Query: 690 AGKLRRL-------------KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGV 736
KL +L + L LQ + ++ N+ E T + +
Sbjct: 3722 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3781
Query: 737 QEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAG 796
Q+ L + + + S K LEQ L L R + S EE+ E
Sbjct: 3782 QDKLEAIKARYKDITKLSTDVAKTLEQAL----QLARRLHSTHEELCTWLDKVEV----- 3832
Query: 797 EKPDVLSQELG-MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 855
++LS E ++GE++S Q +M+ + L +E + LL + L + +L P R
Sbjct: 3833 ---ELLSYETQVLKGEEAS---QAQMRPKELKKEAKNNKALLDS-LNEVSSALLELVPWR 3885
Query: 856 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 915
G+ + +D + D + Q EE+ + +I Q+ A
Sbjct: 3886 AREGLE----KMVAEDNERYRLVSDTITQKVEEIDA--------AILRSQQFDQAADAEL 3933
Query: 916 TWLDDVEERLFVATALLPEETETC-------LFNQEILAKDIKEMSEEMDKNKNLFSQAF 968
+W+ + E++L + E+ +T F EIL K++ +++ K+ + A
Sbjct: 3934 SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH--KDIIDDLVKSGHKIMTAC 3991
Query: 969 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN-FQNDLKVLFTSLADN 1027
E + + ++ L +L + + ++R Q+ ER Q ++N F + L+ L +
Sbjct: 3992 SE--EEKQSMKKKLDKVLKNYDTICQINSERYLQL-ERAQSLVNQFWETYEELWPWLTET 4048
Query: 1028 KYIILQKLANVFE-QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP----SMQ 1082
+ II Q A E + + +Q E +Q + + E I ++ + G +L P S+Q
Sbjct: 4049 QSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQ 4108
Query: 1083 ELSKLQD-MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 1141
E D +Y ++ + R L++ ++ +Q+ + + + LE E++ I
Sbjct: 4109 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSIS 4167
Query: 1142 SSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRA 1201
+ E+I++ + ++K +E L ETL Q E++A++ K
Sbjct: 4168 AEVEKIKEQISENKNVSVDMEKLQPLYETL------------KQRGEEMIARSGGTDKDI 4215
Query: 1202 HKRGVE--LEYILETWSHL----DEDQQELSRQLEVVE-------SSIPSV----GLVEE 1244
+ V+ L+ ++ W ++ +E + +L +E+ E S I ++ + +
Sbjct: 4216 SAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD 4275
Query: 1245 NEDRLIDRITLYQH------LKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQ 1295
ED ID + Q ++ ++ Q +L V++ G L+ + D ++ +++
Sbjct: 4276 LEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDE 4335
Query: 1296 LGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQE 1355
L W S + +LE ++ +YQ + W+ A +L + + +
Sbjct: 4336 LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----PIGTD 4391
Query: 1356 LEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV----DTATLRSELSRIDSQ 1411
LE V+ + +F E Q ++ L+ +LL LKKV D T++ L +
Sbjct: 4392 LETVKQQIEELKQFKSEA-YQQQIEMERLNHQAELL-LKKVTEESDKHTVQDPLMELKLI 4449
Query: 1412 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--YKA 1469
W L I Q KL + +HA+ E+++W++ E ++ + + +G KA
Sbjct: 4450 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-----QKPVGGDPKA 4504
Query: 1470 IHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK-TDFAEQLGAMNKSWQ 1528
I L K+ + D+ Q TV+ VN++ + +ES ++ ++ +L +N+ WQ
Sbjct: 4505 IEIELAKHHVLQNDVLAHQSTVEAVNKA----GNDLIESSAGEEASNLQNKLEVLNQRWQ 4560
Query: 1529 ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNALKD 1587
+ ++ Q L+G L + ++ L+ W E+ L +G + + L
Sbjct: 4561 NVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4620
Query: 1588 CQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKI 1647
++ +AKE+ + + Q G ++ + + + + L + W +++ + + K
Sbjct: 4621 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4680
Query: 1648 LLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 1707
L+ L+ + ++L +A +L+ + L+ V Q+D + +++
Sbjct: 4681 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4740
Query: 1708 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS-------SKA 1760
+ + L + N L V RW +++ + E+ +S +K
Sbjct: 4741 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4800
Query: 1761 LLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTV 1820
+ W + ++ ++ ++ + + N+ D++ T + + K LG
Sbjct: 4801 FHEAWSKLMEWLEESEKSLDSELEIAND-----------PDKIKTQLAQHKEFQKSLGAK 4849
Query: 1821 KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE---QALC----KQQTSLQA 1873
+ G LK++ +++ D L L L L +C ++Q L+
Sbjct: 4850 HSVYDTTNRTGRSLKEK------TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4903
Query: 1874 GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 1933
+L F +L+AL W+ E L P H D+ + ++ K +
Sbjct: 4904 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSS 4962
Query: 1934 LDRLNELGYRLPLNDKEIK-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 1988
+ L L ++ +MQ L+ W + + + + ++L++ L Q + F
Sbjct: 4963 VQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV 5022
Query: 1989 CETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL 2046
+E+L + EQ L + + L H+ F ++ ++ L+ G +L
Sbjct: 5023 VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 5082
Query: 2047 EQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV-E 2105
D +T++ +++ V+ A+Q + + S + +E+ E L WL
Sbjct: 5083 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 5142
Query: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQ-FKEKVFLRQ 2141
+ L +P +++ + L E Q F E++ +Q
Sbjct: 5143 ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5179
Score = 230 bits (587), Expect = 2e-59
Identities = 557/3213 (17%), Positives = 1245/3213 (38%), Gaps = 497/3213 (15%)
Query: 264 YEQYEQEMKHLQQLIEGAH----REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQI 319
Y Y E+++++ +E R+I P+ ++ E +I+ E+L ++++ ++ +
Sbjct: 1243 YNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDLHESVFRITEQEKLKKELERLKDDL 1301
Query: 320 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 379
++ +KC+ +A ++ + PT + +VV+ + ++
Sbjct: 1302 GTITNKCEEFFSQAAASSSV---------------------PTLRSELNVVLQNMNQVYS 1340
Query: 380 LLSP----------VTEESGEEGTNSEISSPPACRSPSPVANTDASVN--QDIAYYQALS 427
+ S V + + ++ C + +A+ + N + +++
Sbjct: 1341 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV 1400
Query: 428 AERLQTDAA---KIHPSTSASQEFYEPGLEPSAT-----AKLGDLQRSWETLKNVISEKQ 479
E+ Q A ++ + + S E ++ E K L W+ + I +
Sbjct: 1401 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1460
Query: 480 RTLYEALERQQKYQDSLQSISTKMEAIEL---KLSES-PEPGRSPESQMAEHQALMDEIL 535
R L + + Y+D+ + ++ +E K+ E+ PE ++ +Q+ + + L+ EI
Sbjct: 1461 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1520
Query: 536 MLQDEINELQS---------------SLAEELVSESCEADPAEQLALQSTLTVLAERMST 580
M Q +++E Q ++ + +S + P ++ +QS+ ++ +
Sbjct: 1521 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1580
Query: 581 IRMKASGKRQLLEEKLN---DQLEE-QRQEQALQRYRCE----ADELDSWLLSTKATLDT 632
+R + + L+ + + D L+ + +E++L+ + E A EL W+ + TL
Sbjct: 1581 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1640
Query: 633 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 692
A K P Q + + + + EQ AL + + L G T +E +L +
Sbjct: 1641 AEKAGKPP--FSKQKISSEEISTKKEQLSEALQTIQLF---LAKHGDKMTDEERNELEKQ 1695
Query: 693 LRRLKGS----LLELQRALHDKQLNMQGTAQEKEESDVD-------------LTATQSPG 735
++ L+ S E + L + Q + +EK ++ LT T++
Sbjct: 1696 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1755
Query: 736 VQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 795
+ A T + + +Q+EL++++ L V E L ++
Sbjct: 1756 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN--------- 1806
Query: 796 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQ--KLLQNVLEQEQEQVLYSRP 853
GEK LSQE E+ E +++ + +L E S K+ K++ +++E E+V +
Sbjct: 1807 GEK---LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1863
Query: 854 NRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSA 913
+ K+ + +LLD L+ + S+ G K + + +
Sbjct: 1864 LE--------------ESKTKIENLLDWLSNV--DKDSERAGTKHKQV---------IEQ 1898
Query: 914 TSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD 973
T + + + + + EE E N +L D+ + +NL Q
Sbjct: 1899 NGTHFQEGDGK-----SAIGEEDEV---NGNLLETDVD--GQVGTTQENLNQQYQKVKAQ 1948
Query: 974 NRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLF-TSLADNKYIIL 1032
+ +I ++ S + Q + E +++ +LKV + T+LA+++
Sbjct: 1949 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESE---- 2004
Query: 1033 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 1092
++++ ++ L++FDA E + LQ + ++ L D +
Sbjct: 2005 ------------KKMKLTHSLQEELEKFDADYTEFEH---WLQQSEQELENLEAGADDIN 2049
Query: 1093 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQ--EKMAGDQKIIVSSKEEIQQL 1150
LM + ++S ++ K +LE + K G + ++ E+Q+
Sbjct: 2050 GLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRK 2109
Query: 1151 LDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEY 1210
LD + F+ L S + + ++ Q L+A A A K
Sbjct: 2110 LDHATDRFRSLYSKCNVLGNNLKDLVD-KYQHYEDASCGLLAGLQACEATASK------- 2161
Query: 1211 ILETWSHLDE----DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 1266
HL E D + L RQLE ++ + + ++L + + SL
Sbjct: 2162 ------HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPA 2215
Query: 1267 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 1326
+ + + LDD I DL +N+ E +L+ L Q
Sbjct: 2216 KNDIQKTLDD-----IVGRYEDLSKSVNERNE--------------KLQITLTRSLSVQD 2256
Query: 1327 ESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
+++ W+ + + L ++ VP ++D ++ + +++ + S ++
Sbjct: 2257 GLDEMLDWMGNVESSL----KEQGQVPLNSTALQDIISKNIMLEQDIAG----RQSSINA 2308
Query: 1387 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 1446
N+ ++KK T S S + ++ DL K H+ + K+ E+ +
Sbjct: 2309 MNE--KVKKFMETTDPSTASSLQAKMKDLSARFSEASHK-HKETLAKM------EELKTK 2359
Query: 1447 ISLMENVIQKDEDNIKN--------SIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ L EN+ +K + ++ + K + E Q + + + ++ ++ +
Sbjct: 2360 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 2419
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 1558
+ISS + SDK E+ ++K ++ ++ + EK + + E ++ V+ L
Sbjct: 2420 KEISSHGLP---SDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2476
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL------ 1612
K+W + K++ + +L+D + L++ K E++K+ +G++L
Sbjct: 2477 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2536
Query: 1613 IQNKKEDVSSIVM--------STLRELGQTWAN------------LDHMVGQLKILLKSV 1652
+ + ++++ T + WAN + H L +LLK
Sbjct: 2537 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2596
Query: 1653 LDQWSSHKVAFDK-------INSYLMEARYSLSRFRLLTG--SLEAVQVQVDNLQNLQDD 1703
+ + ++ K + +L + + ++++ EAV+ QV+ ++ + +
Sbjct: 2597 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2656
Query: 1704 LEKQERSLQKFGSITNQLLKE-CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALL 1762
L++ +Q+ +LL+E P L E++ +W L + ++ Q +
Sbjct: 2657 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2716
Query: 1763 QLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKD 1822
+++ Q + ++E + L + + ++ + T Q LL+ T K
Sbjct: 2717 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN----TQRQQVQILLQEFATRKP 2772
Query: 1823 SLFFLHELGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYET 1880
L G+ + + D S ++ +++Q +L L + + ++
Sbjct: 2773 QYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ 2832
Query: 1881 FAKSLEALEAWIVEAEEILQG------QDPSHSSDLSTIQERMEEL---KGQMLKFSSMA 1931
+ L +L + + + L + + L T Q+ +E+ K Q+ ++
Sbjct: 2833 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC 2892
Query: 1932 PDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL---QHQTFLEK 1988
DL L + Y L + ++++ + + + + + LQS Q Q
Sbjct: 2893 EDLSALVKEEY---LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2949
Query: 1989 CETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ 2048
+ W++ + EQ + IS L + H+ F + ++ + I +G+ LL +
Sbjct: 2950 FQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 3008
Query: 2049 GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKW------ 2102
Q ++ L+L + W ++ ++R + + + +Y+E E L W
Sbjct: 3009 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 3068
Query: 2103 -LVEVSYL--PMSG-----------------LGSVPIPLQQARTLFDEVQFKEKVFLRQQ 2142
L E+ + P G G V + A +L + ++V +
Sbjct: 3069 NLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN 3128
Query: 2143 GSYILTVE------------------------------------AGKQLLLSADSGAEAA 2166
S I V+ A +QL + G++A
Sbjct: 3129 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3188
Query: 2167 LQAELAEIQEKWKS--ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK---LS 2221
L +Q + KS A + K+LA L KG +D L ++ T ++ LS
Sbjct: 3189 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3248
Query: 2222 QSLPDHHEELHAE-------QMRCKELENAVGSWTDDLTQLSLL----------KDTLSA 2264
Q + + L + Q +E+ + + D+L ++ + K+T+ A
Sbjct: 3249 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3308
Query: 2265 YI-------------------------SADDISILNERVELLQRQWEELCHQLSLRRQQI 2299
++ ++ D+ + +E L +Q +L + R +Q+
Sbjct: 3309 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3368
Query: 2300 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQ 2354
+ F K KE L + E G + I + + K +EEI Q
Sbjct: 3369 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3428
Query: 2355 ENKIQLQQMGERLAKASHESKASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ 2413
+ + +G+ L +++ +S +++ +E+ L VN RW+ L +A R +L+E L+ +
Sbjct: 3429 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3488
Query: 2414 LDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
+ SL +W+ E +A KP S + ++ ++ EQ+ LQR ++ + V
Sbjct: 3489 FQDALESLLSWMVDTEELVANQKP---PSAEFKVVKAQIQEQKLLQRLLDDRKSTV---- 3541
Query: 2472 NLCEVLLHDCDACATDAE-CDSIQ--QATRNLDRRWRNICAMSMERRLKIEETWRLWQKF 2528
EV+ + + AT AE D ++ + LD RW + + R ++E + Q+F
Sbjct: 3542 ---EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3598
Query: 2529 LDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV---HECLTQLELINK 2585
+ +WL + E+ G + +E++ + +A + + ++ L Q I +
Sbjct: 3599 HETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ 3658
Query: 2586 QYRRLARENRTDSACSLKQMVHEGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSI 2644
+ L+ D + Q + +Q W +Q++ S L+ + + F +
Sbjct: 3659 SLKVLSSREDKD----MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVEL 3714
Query: 2645 LVWLTEMDLQLT--NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 2702
+ WL E+ +L+ +++ +S + + +L+ Q++I L ++Q + G +L++++
Sbjct: 3715 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTT 3774
Query: 2703 PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDL 2762
+ II+++L+ ++ +++ L D ++ L+L + L
Sbjct: 3775 GDEVLIIQDKLEAIKARYKDI-------------TKLSTDVAKTLEQALQL--ARRLHST 3819
Query: 2763 H-----WHDRSADSLLSPQ----PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 2813
H W D+ LLS + S + +P ++ ++ A +DS+
Sbjct: 3820 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL-------- 3871
Query: 2814 DLSRDLESAMSRALPSEDEEG-----QDDKDFYLRGAVGLSGDHSALESQI---RQLGKA 2865
++ SA+ +P EG +D + Y + ++ +++ I +Q +A
Sbjct: 3872 ---NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3928
Query: 2866 LDDSRFQIQQTENIIRS-------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
D I +TE + S + T +L M++L ID + + HK+
Sbjct: 3929 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDLVKSGHKI 3987
Query: 2919 ----KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLN 2974
EEE+ S + + V+ ++ + + L++++ QF
Sbjct: 3988 MTACSEEEK--------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 4039
Query: 2975 SIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFT 3034
+W WL +T+ + QL L + +T+ Q ++ ++L++ + K I +N P+
Sbjct: 4040 ELWPWLTETQSIISQLPAPAL--EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 4097
Query: 3035 QADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 3094
+ E +Q++ + + ++ +++ L +A+ Q FH+ +L LE I
Sbjct: 4098 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4157
Query: 3095 RRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE 3154
R + P + + E +++ + + ++ + Q +L+ +++ + GTD
Sbjct: 4158 ERLRQ--PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI 4215
Query: 3155 AKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDV 3186
+ + V +++ + + + ++E E KLLDV
Sbjct: 4216 SAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4248
Score = 210 bits (534), Expect = 2e-53
Identities = 462/2514 (18%), Positives = 971/2514 (38%), Gaps = 299/2514 (11%)
Query: 21 LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 80
L++++ + + + ++AEN + L A + ++ +M W++ K
Sbjct: 2908 LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQ 2961
Query: 81 NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEEL 140
N + + + + ++L+++ K+ L A + ++ E + + G E L
Sbjct: 2962 NKSHPISAKLDVLESLIKDHKDFSKTLTAQS----HMYEKTIAEGENLLLKTQGSEKAAL 3017
Query: 141 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLL 200
+ + N K +K+ E KL+ +LE+A L KEQ+ + L
Sbjct: 3018 QLQLNTIKTNWDTFNKQVKERE---NKLKESLEKA-----------LKYKEQV---ETLW 3060
Query: 201 SEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------ 254
++ + ++ ++ C E+ +A L LQ+E QH + +
Sbjct: 3061 PWIDKCQNNLEEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTAN 3111
Query: 255 NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEE 307
+++ + E E K L Q ++ ++ K N+ QE+ + R +
Sbjct: 3112 SLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ 3171
Query: 308 LAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLA--------------EGTE 353
A++ + + S K LTM L + LA +GT
Sbjct: 3172 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTS 3231
Query: 354 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSP 408
D+ ++ H ++ +C L + + + T E+ S A S +P
Sbjct: 3232 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3291
Query: 409 VANTDASVNQD----IAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL 464
V ++ + A+ + L A D A + E P L L L
Sbjct: 3292 VGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL-VGIKRDLEAL 3350
Query: 465 QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---E 521
+ L + ++ + ++R +++ L+ S I L+ +E E + P E
Sbjct: 3351 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGME 3405
Query: 522 SQMAEHQALMDEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLA 575
++ Q M ++ ++EI LQ L + L+ + ++ + L+ L +
Sbjct: 3406 TETINQQLNMFKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVN 3462
Query: 576 ERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALS 635
R T+ K + + L+E L L R + AL + L SW++ T+ +
Sbjct: 3463 ARWKTLNKKVAQRAAQLQEAL---LHCGRFQDAL-------ESLLSWMVDTEELVANQKP 3512
Query: 636 PPKEPMDMEAQ---------LMDCQNMLVEI--------------EQKVVALSELSVHNE 672
P E ++AQ L+D + VE+ KV L +LS+ +
Sbjct: 3513 PSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3572
Query: 673 NL-LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLT 729
L KA T++ R+L+G + Q+ H+ + LN T EK + +
Sbjct: 3573 RWEALLNKAETRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPI 3622
Query: 730 ATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA- 788
TQ+ ++E +AQ + + K L Q ++ +S L+ ++SR ++ ++Q
Sbjct: 3623 GTQASKLEEQIAQHKAL----EDDIINHNKHLHQAVSIGQS-LKVLSSREDKDMVQSKLD 3677
Query: 789 ------AETSGDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFST 832
E + + ++L Q L K ED++ M W +H Q++ST
Sbjct: 3678 FSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST 3735
Query: 833 KQK-LLQNVLEQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEE 888
+ Q+ L QE +L + N LL+G+ L K + + L+ + +++
Sbjct: 3736 EGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKD 3794
Query: 889 VSSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQ 943
++ S + Q++ L ++L+ TWLD VE L + L EE
Sbjct: 3795 ITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP 3854
Query: 944 EILAKDIKEMSEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVV 996
+ L K+ K +D + N S A E G + V ED R L+ +
Sbjct: 3855 KELKKEAKNNKALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTI 3908
Query: 997 NQRCHQMKERLQQILNFQN--DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAE 1054
Q+ ++ + + F D ++ + + + K + L + +Q A+
Sbjct: 3909 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3968
Query: 1055 DGLKEFDAGIIELKRRGDKL------QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN 1108
+ L+ D I +L + G K+ + +Q ++L K+ YD + I R L +
Sbjct: 3969 EILRHKDI-IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERA 4027
Query: 1109 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILT 1168
+L +Q+ ++L L T + + E ++Q ++H++ + + H
Sbjct: 4028 QSLVNQFWETYEELWPWL-TETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 4086
Query: 1169 ETLFR---KII------SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLD 1219
+ + + +++ F++Q++ L +Q +K KR V L+ + +
Sbjct: 4087 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK---KRAVALDEAISQSTQFH 4143
Query: 1220 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 1279
+ ++ LE + + + +++ ++I+ +++ + + QP LY+ L
Sbjct: 4144 DKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQP-LYETLKQRGE 4202
Query: 1280 LLIS--------ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 1331
+I+ IS ++ +L+Q+ W + + + +L +++ ++ + L
Sbjct: 4203 EMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4262
Query: 1332 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 1391
I ++ +D + + + +V+ A +E+D V++ G++L+
Sbjct: 4263 IVTIKDTQDFIRDLEDPGI----DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4318
Query: 1392 -RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM 1450
+ D ++ + ++S W L +KL + + + + V W+ +
Sbjct: 4319 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4378
Query: 1451 ENVIQKDEDNIKNSIG--YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 1508
+ + IG + + + +++ K FK + +Q+ ++ +N + + E
Sbjct: 4379 GGKLAS-----MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE- 4432
Query: 1509 KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 1568
SDK + L + W L+ + + LEG L + ++++ + L W E
Sbjct: 4433 -ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4491
Query: 1569 LKQQHRI-GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 1627
L +Q + GD +++ L L++ + A + VE + + G LI++ + +S + +
Sbjct: 4492 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4551
Query: 1628 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSL 1687
L L Q W N+ Q K L L Q + + +L + L + L G
Sbjct: 4552 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4611
Query: 1688 EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNL 1747
E + Q++ + E +E + + Q+L C + + + +W ++
Sbjct: 4612 ETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4671
Query: 1748 LEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWI 1807
++ E+ + L L + + + + + Q E + L A+ + D V I
Sbjct: 4672 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE----QTLNVASRPSLILDTVLFQI 4727
Query: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
+ + + ++ + L + G LK I++ +S+ + Q L ++
Sbjct: 4728 DEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4787
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
SL + F ++ L W+ E+E+ L + ++D I+ ++ + K
Sbjct: 4788 GRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD-SELEIANDPDKIKTQLAQHKEFQKSL 4846
Query: 1928 SSMAPDLDRLNELGYRL----PLNDKEIK---RMQNLNRHWSLISSQTTERFSKLQSFLL 1980
+ D N G L L D +K + L W I ++ ER +KL+ LL
Sbjct: 4847 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4906
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSI 2038
F + + +++L + E +LA + + G+ ++ H+ FQ E+ R + ++
Sbjct: 4907 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL 4966
Query: 2039 IIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
+ L+E G DD +++ LS +W+ V + ++ +++ +RQ + + +
Sbjct: 4967 KRSARELIE-GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 5025
Query: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158
L +WL E + G +P RTL D+ + K ++ G +L
Sbjct: 5026 LLEWLAEAEQ-TLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI 5084
Query: 2159 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF----LLKDWEKCEKGIADSLEKLR 2214
+ ++ + I+ +++ ++ +++LA L+ E E +A
Sbjct: 5085 CHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAET 5144
Query: 2215 TFKKKLSQSLPDHHEELHA---------EQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
T K + +P EE+ A E+M K+ + V T + + +L ++
Sbjct: 5145 TLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPD--VDKVTKTYKRRAADPSSLQSH 5202
Query: 2266 I----------------------SADDISILNERVELLQRQWEELCHQLSLRRQQIG--- 2300
I S I N RV LL +W+++ RR+++
Sbjct: 5203 IPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDAL 5262
Query: 2301 ---ERLNEWAVFSEK--NKELCEWLTQMESKV---------SQNGDILIEEMIE 2340
E L E+A F K+ W+ +S+V Q+G I +E I+
Sbjct: 5263 DRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFID 5316
Score = 203 bits (516), Expect = 3e-51
Identities = 501/2642 (18%), Positives = 1024/2642 (38%), Gaps = 403/2642 (15%)
Query: 2 ELDAAVQKFLEQNGQLGKP---LAKKIGKLTELHQQTIRQAENRLSKLNQAAS------- 51
+L A QK+ GQL + + I K T+ +Q +R ++LS L+ S
Sbjct: 2801 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ-YQSLLRSLSDKLSDLDNKLSSSLAVST 2859
Query: 52 HLEEYNEMLELILKWI-----EKAKVLAHGTIAWNSASQLREQYILHQT------LLEES 100
H + N+ LE K EK ++ + + ++ ++E+Y+ + +L+
Sbjct: 2860 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSF 2919
Query: 101 KEIDSELEAMTEKLQYLTSVYCTEKMSQQVA-------ELGRETEELRQMIKIRLQNLQD 153
K+++ + E +Q+L S + QQ++ + +E + I +L L+
Sbjct: 2920 KDVEQKAE---NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLES 2976
Query: 154 AAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV 213
KD K F K L A + T+ E L LK Q S + L ++ ++K
Sbjct: 2977 LIKDHKDFS---KTLTAQSHMYEKTIAEGE--NLLLKTQGSEKAALQLQLNTIKTNWDTF 3031
Query: 214 ------------QLCQSALRIPEDVVASLPL---CHAALR-------------------- 238
+ + AL+ E V P C L
Sbjct: 3032 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 3091
Query: 239 LQEEASRLQHTAIQQC------NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVAT 292
LQ+E QH + + +++ + E E K L Q ++ ++ K
Sbjct: 3092 LQKEMD--QHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3149
Query: 293 SNI-------QELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 345
N+ QE+ + R + A++ + + S K LTM L +
Sbjct: 3150 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3209
Query: 346 EGLAE--------------GTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEE 391
LA+ GT D+ ++ H ++ +C L + + +
Sbjct: 3210 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3269
Query: 392 GTNSEISSPPA-----CRSPSPVANTDASVNQDI----AYYQALSAERLQTDAAKIHPST 442
T E+ S A S +PV ++ + A+ + L A D A
Sbjct: 3270 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 3329
Query: 443 SASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTK 502
+ E P L L L + L + ++ + ++R +++ L+ S
Sbjct: 3330 MLATEETSPDLV-GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS-- 3386
Query: 503 MEAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSS------LAEELV 553
I L+ +E E + P E++ Q M ++ ++EI LQ L + L+
Sbjct: 3387 ---ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ-KEEIEPLQGKQQDVNWLGQGLI 3442
Query: 554 SESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYR 613
+ ++ + L+ L + R T+ K + + L+E L L R + AL+
Sbjct: 3443 QSAAKSTSTQ--GLEHDLDDVNARWKTLNKKVAQRAAQLQEAL---LHCGRFQDALE--- 3494
Query: 614 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQ---------LMDCQNMLVEI------- 657
L SW++ T+ + P E ++AQ L+D + VE+
Sbjct: 3495 ----SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3550
Query: 658 -------EQKVVALSELSVHNENL-LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD 709
KV L +LS+ + L KA T++ R+L+G + Q+ H+
Sbjct: 3551 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRN---------RQLEGISVVAQQ-FHE 3600
Query: 710 --KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 767
+ LN T EK + + TQ+ ++E +AQ + + K L Q ++
Sbjct: 3601 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKAL----EDDIINHNKHLHQAVSI 3656
Query: 768 QKSLLRSVASRGEEILIQHSA-------AETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 820
+SL + ++SR ++ ++Q E + + ++L Q L K ED++
Sbjct: 3657 GQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVE 3713
Query: 821 -MKW-ESLH--------QEFSTKQKLLQ-NVLEQEQEQVLYSRPN---RLLSGVPLYKGD 866
M W +H Q++ST+ Q + L QE +L + N LL+G+ L K
Sbjct: 3714 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLK-Q 3772
Query: 867 VPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEE 923
+ + L+ + +++++ S + Q++ L ++L+ TWLD VE
Sbjct: 3773 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3832
Query: 924 RL--FVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPE-------NGDN 974
L + L EE + L K+ K +D + N S A E G
Sbjct: 3833 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD-SLNEVSSALLELVPWRAREGLE 3891
Query: 975 RDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 1034
+ V ED R L+ + Q+ ++ + +
Sbjct: 3892 KMVAEDN-----ERYRLVSDTITQKVEEIDAAILR------------------------- 3921
Query: 1035 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 1094
+ F+Q ++ I + E L +E + +LQV++ E+ + +D+ D+L
Sbjct: 3922 -SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3980
Query: 1095 MMIIGSRRSGLNQN--LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 1152
+ + ++ ++K + ++ L++ + + E+ E Q L++
Sbjct: 3981 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYL--------QLERAQSLVN 4032
Query: 1153 KHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYIL 1212
+ E ++ L LTET + IIS +L A A LEY
Sbjct: 4033 QFWETYEELWPW--LTET--QSIIS-----------QLPAPA-------------LEY-- 4062
Query: 1213 ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQ 1272
ET QQE RQL L+ E++ + +N+ P+L +
Sbjct: 4063 ETL----RQQQEEHRQLRE---------LIAEHKPHI-----------DKMNKTGPQLLE 4098
Query: 1273 VLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLI 1332
L G+ I ++ +Q+ E + K L+ + T++ + ++
Sbjct: 4099 -LSPGEGFSIQEKYVAADTLYSQIKE-------DVKKRAVALDEAISQSTQFHDKIDQIL 4150
Query: 1333 HWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR 1392
L+ +RL +Q ++ E+E +++ ++ S +++ L ++ G +++
Sbjct: 4151 ESLERIVERL----RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 4206
Query: 1393 L-----KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 1447
K + ++ +L ++ W ++ T + + KL L + +L + MS I
Sbjct: 4207 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKL--LDVMELAEKFWCDH-MSLI 4263
Query: 1448 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVE 1507
+++ D I + + + + + +I+ Q +D V + + S+ +
Sbjct: 4264 VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIV----INLGSELIA 4319
Query: 1508 S-KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 1566
+ DK + + +N +W L ++I LE +++ +Y++ +Q + W +
Sbjct: 4320 ACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 4379
Query: 1567 KRLKQQHRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSS-IV 1624
+L IG D +V+ +++ + + ++ E+E++ L++ E+ V
Sbjct: 4380 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTV 4439
Query: 1625 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLT 1684
L EL W +L+ + + L+ L + A D++ ++L LS + +
Sbjct: 4440 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4499
Query: 1685 GSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRW 1744
G +A+++++ LQ+D+ + +++ N L++ L N L+ +N RW
Sbjct: 4500 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4559
Query: 1745 NNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN---KDIADD 1801
N+LE+ ++ Q L+ + K + + Q D LL + + A +
Sbjct: 4560 QNVLEKTEQRKQQLDGALR---QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKE 4616
Query: 1802 EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE 1861
++ ++ C T K L + G+Q+ + SA + I D +L + ++E
Sbjct: 4617 QLNVHMEVCAAFEAKEETYKS----LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4672
Query: 1862 QALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELK 1921
L +++T L+ + F SL+ W+ +AE+ L S L T+ +++E K
Sbjct: 4673 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP-SLILDTVLFQIDEHK 4731
Query: 1922 GQMLKFSSMAPDLDRLNELGYRLPL--NDKEIKRMQNL----NRHWSLISSQTTERFSKL 1975
+ +S + L++ G L +++ ++NL W + + ER L
Sbjct: 4732 VFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL 4791
Query: 1976 QSFLLQHQTFLEKCETWMEFLVQTEQKL--AVEISGNYQHLLEQQRAHELFQAEMFSRQQ 2033
+ + F E ME+L ++E+ L +EI+ + + Q H+ FQ + ++
Sbjct: 4792 DDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHS 4851
Query: 2034 ILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRY 2092
+ + G+ L E+ + DD + + L+ L ++W + ++ +R+ ++ + ++
Sbjct: 4852 VYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4911
Query: 2093 REMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAG 2152
+ + L WL V ++ V + L D K F ++ G +V+A
Sbjct: 4912 TDALQALIDWLYRVEP-QLAEDQPVHGDIDLVMNLIDN----HKAFQKELGKRTSSVQAL 4966
Query: 2153 KQL---LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADS 2209
K+ L+ + ++ ++ E+ +W++ ++ +L L+ E+ +
Sbjct: 4967 KRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL 5026
Query: 2210 LEKLRTFKKKLSQS--LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS 2267
LE L ++ L LPD + L + KE + +L + + + DT+ A
Sbjct: 5027 LEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICH 5086
Query: 2268 ADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV 2327
D I+ + + +++ ++EE+ +Q++ L E + L WL E+ +
Sbjct: 5087 PDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTL 5146
Query: 2328 SQNGDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAK-----ASH---- 2372
+ +I + IE++K + + EE+ Q + ++ + +R A SH
Sbjct: 5147 TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVL 5206
Query: 2373 -----------------ESKASEIEYKLGKVN---DRWQHLLDLIAARVKKLKETLVAVQ 2412
++IE K +VN +WQ + L R +KL + L ++
Sbjct: 5207 DKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLE 5266
Query: 2413 QL 2414
+L
Sbjct: 5267 EL 5268
Score = 182 bits (462), Expect = 5e-45
Identities = 617/3357 (18%), Positives = 1313/3357 (39%), Gaps = 415/3357 (12%)
Query: 28 LTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLR 87
L L IR+ + S L+Q + E + ++ +L W+++ +V T W S
Sbjct: 754 LQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT-EWGSDLPSV 812
Query: 88 EQYIL-HQTLLEESKEIDSEL-EAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIK 145
E ++ H+ + +E +S L EA ++Q + T ++++ L + +L +
Sbjct: 813 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT--YAEKLHRLESQYAKLLNTSR 870
Query: 146 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMES 205
+ ++L + + EL L E+ A S ++ K+ + L+ E++
Sbjct: 871 NQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKD--YHAELMRELDQ 928
Query: 206 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ-- 263
+ +++VQ L + E+ A L + +Q + S + +Q C ++ + +
Sbjct: 929 KEENIKSVQEIAEQLLL-ENHPARLTIEAYRAAMQTQWSWI----LQLCQCVEQHIKENT 983
Query: 264 -YEQYEQEMKHLQQLIEGAHREIEDKPVA--TSNIQELQAQISRHEELAQKIKGYQEQIA 320
Y ++ + K + I+ K +S+I +L+ + E +++ Y+ IA
Sbjct: 984 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 1043
Query: 321 SLNSKCK-MLTMKAKHATM-LLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 378
+L K K ++ +K +++ L T ++ + + + + + + A H
Sbjct: 1044 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI-------EITIYKDDECVLANNSH 1096
Query: 379 TLLSPVTEESGEEGTNSEI--SSPPACRSPSPVANTDASVNQDIAYY---------QALS 427
V +G E + + PP + +AN Q++ +S
Sbjct: 1097 RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 1156
Query: 428 AERLQTDAAKIHPSTSAS----------------QEFYEPGLEPSATAKL--GDLQRSWE 469
L + +I S AS Q +E LE S +++ G E
Sbjct: 1157 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1216
Query: 470 TLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPE----PGRSP----- 520
NV + + L ++ ER+++ + +++ I L+L + R+P
Sbjct: 1217 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1276
Query: 521 --ES--QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 576
ES ++ E + L E+ L+D++ + + EE S++ + L+S L V+ +
Sbjct: 1277 LHESVFRITEQEKLKKELERLKDDLGTITNK-CEEFFSQAAASSSVP--TLRSELNVVLQ 1333
Query: 577 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 636
M+ + +S L+ Q E ++ Y + E ++ +++ K ++ +S
Sbjct: 1334 NMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA-VIADKNNIENLIST 1392
Query: 637 PKEPMDMEAQLMDCQNMLVEIEQKVVALS-ELSVHNENLLLEGKAHTKDEAEQLAGKLRR 695
K+ + + L + QK A+S E+ + L+ H K++A+QL + R
Sbjct: 1393 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH-KEKADQL---VER 1448
Query: 696 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSL 755
+ +++ L D ++G + + T P + +W+ Q TT + +++
Sbjct: 1449 WQNVHVQIDNRLRD----LEGIGKSLKY----YRDTYHP-LDDWIQQVETTQRKIQENQP 1499
Query: 756 QQQKELEQELAEQKSLLRSVASRGEEI-LIQHSAAETSGDAGE-KPDVLSQELGMEGEKS 813
+ K L +L +QK L+ + + ++ Q A + S + + ++ ++ ++
Sbjct: 1500 ENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1559
Query: 814 SAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS 873
S + RM+ S+ ++Q ++ L +R L++ + Y K
Sbjct: 1560 SPVKRRRMQ--------SSADLIIQEFMD------LRTRYTALVTLMTQY-------IKF 1598
Query: 874 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLP 933
A SL + EE K++ + ++L VS S L D E+ A P
Sbjct: 1599 AGDSL-----KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK------AGKP 1647
Query: 934 EETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 993
++ + ++EI K KE E + LF ++GD + D
Sbjct: 1648 PFSKQKISSEEISTK--KEQLSEALQTIQLF---LAKHGD----------------KMTD 1686
Query: 994 SVVNQRCHQMKERLQQILN--FQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQ 1051
N+ Q+K LQ+ N F LK L S + +K+ +Q E+++ I
Sbjct: 1687 EERNELEKQVK-TLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGIC 1745
Query: 1052 QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111
+ G E GD EL K Q +EL + L +
Sbjct: 1746 DLLTQTENRLIGHQEAFMIGD-------GTVELKKYQSKQEELQKDMQGSAQALAE---- 1794
Query: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 1171
+++ + L+ EK++ + K + I+Q L++ K + L ++
Sbjct: 1795 ------VVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLNLKAEQSKKE 1842
Query: 1172 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL-SRQLE 1230
K+++ A+++ET + A +K+ + ++E +L+ S++D+D + ++ +
Sbjct: 1843 LDKVVTTAIKEET--------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQ 1894
Query: 1231 VVESS---------IPSVGLVEENEDRLIDRI------TLYQHLKSSLNEYQPKLYQVLD 1275
V+E + ++G +E L++ T ++L + + + +++
Sbjct: 1895 VIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIIS 1954
Query: 1276 DGKRLLISISCSD--LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIH 1333
+ ++I+ + LE Q L K+ K + L+ + + L H
Sbjct: 1955 QHQAVIIATQSAQVLLEKQGQYLSP---EEKEKLQKNMKELKVHYETALAESEKKMKLTH 2011
Query: 1334 WLQSAKDR-------LEFWTQQSVTVPQELEMVRDHLNAFL-------EFSKEVDAQSSL 1379
LQ ++ E W QQS + LE D +N + FS++V +
Sbjct: 2012 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 2071
Query: 1380 KSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 1439
+ +GN++L K S+ D D VQ KL D+ S ++
Sbjct: 2072 LRYITISGNRVLEAAK--------SCSKRDGGKVDTSATHREVQRKLDH-ATDRFRSLYS 2122
Query: 1440 ISEVM--SWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQS 1497
V+ + L++ ++ + G +A K+ I ++ K L
Sbjct: 2123 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2182
Query: 1498 VL--QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 1555
L QISSQ V ++ KT AE L S + + + + + G E S+ N
Sbjct: 2183 ALQGQISSQQVAVEKLKKT--AEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN-- 2238
Query: 1556 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 1615
E+ K Q + SVQ+ L + D +++ KE ++ N AL
Sbjct: 2239 ----------ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL--- 2285
Query: 1616 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV-LDQWSSHKVAFDKINSYLMEAR 1674
+D+ S + +++ ++++ M ++K +++ SS + +++ EA
Sbjct: 2286 --QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEAS 2343
Query: 1675 YSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP---VTE 1731
+ + + +E ++ +V+ +NL + LQ F Q L E P VTE
Sbjct: 2344 H---KHKETLAKMEELKTKVELFENLSE-------KLQTFLETKTQALTEVDVPGKDVTE 2393
Query: 1732 TLTNTLKEVNMRW----------NNLLEEIAEQ-LQSSKAL-LQLWQRYKDYSKQCASTV 1779
L+ ++E + ++LL+EI+ L S KAL L+ K+ T+
Sbjct: 2394 -LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTI 2452
Query: 1780 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 1839
+++++ + + + +WI++ K + V+ S F +LG+ L+
Sbjct: 2453 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETT---KKVPIVQPS-FGAEDLGKSLEDTKK 2508
Query: 1840 ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL 1899
++++ ++ Q + SL + T AK++ A+++ +L
Sbjct: 2509 LQEKWSLKTPEI----------QKVNNSGISLCNLISAVTTPAKAIAAVKS----GGAVL 2554
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNR 1959
G+ + +++ + + +K M S DL L L DK + LN
Sbjct: 2555 NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLL--------LKDK----IAELNT 2602
Query: 1960 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQR 2019
S + E + +Q ++T W + T+ + AV+ +EQ +
Sbjct: 2603 KLSKLQKAQEESSAMMQWLQKMNKT----ATKWQQTPAPTDTE-AVKTQ------VEQNK 2651
Query: 2020 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
+ E + ++ Q L + + L E + + LT + ++WQ + + R+
Sbjct: 2652 SFEAELKQNVNKVQELKDKLT--ELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2709
Query: 2080 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 2139
++ +++ + +L++WLVE L +S LG + I T +VQ + F
Sbjct: 2710 QKLEESSNNLTQFQTVEAQLKQWLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2768
Query: 2140 RQQGSYILTVEAGKQLLL--SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 2197
++ Y AG+ +L D ++ +LA + +KW S + +L ++ + +
Sbjct: 2769 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2828
Query: 2198 DWEKCEKGIADSLEKLRTFKKKLSQSL--PDHHEELHAEQMRCKELENAVGSWTDDLTQL 2255
+ + + +KL KLS SL H + ++ + ++++ + +
Sbjct: 2829 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2888
Query: 2256 SLLKDTLSAYISADDISI-LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK 2314
L + LSA + + + L+ ++E + + ++++ + Q + F + ++
Sbjct: 2889 QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSR 2948
Query: 2315 ELCEWLTQMESKVSQNGDILIE-EMIEKLKKDYQE--EIAIAQENKIQLQ-QMGERLAKA 2370
+ WL + + +++ I + +++E L KD+++ + AQ + + GE L
Sbjct: 2949 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 3008
Query: 2371 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 2430
+ S+ + ++ +L + W + R KLKE+L + + + +L W+ ++
Sbjct: 3009 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 3068
Query: 2431 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD---ACATD 2487
L + + + E + + + + LQ+++++H V + N LL C+ TD
Sbjct: 3069 NLEE--IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 3126
Query: 2488 AECDSIQQATRNLDR-RWRNICAMSMERRLK-IEETWRLWQKFLDDYSRFEDWLKSSERT 2545
IQ+ ++ + C +M ++ K +E + ++ L D + S +
Sbjct: 3127 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD-IHDSLGS 3185
Query: 2546 AAFPSSSGVIYTVAKEELKKFEAFQRQV--------------------HECLTQLELINK 2585
A+ S T+ + + K +A + QV + L Q+E I +
Sbjct: 3186 QAY---SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQ 3242
Query: 2586 QYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSIL 2645
++ L+++ D CS + +G + N ++ Q EF+ DS
Sbjct: 3243 EHSTLSQQ--VDEKCSFLETKLQGIGHFQN----------TIREMFSQFAEFDDELDS-- 3288
Query: 2646 VWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 2705
+ + ++ E ++A +K+L+A + + ++A E++ P D
Sbjct: 3289 --MAPVGRDAETLQKQKE-TIKAFLKKLEALMASNDNANKTCKMMLA-----TEETSP-D 3339
Query: 2706 AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 2765
I+ +L+ L + C ++ R + +++ +E +E S L H
Sbjct: 3340 LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF----SILLQKAEEH 3395
Query: 2766 DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR 2825
+ S + + N L++ + + E P + W L + L + ++
Sbjct: 3396 EESQGPVGMETETINQQLNMFKVFQKEEI---EPLQGKQQDVNW-----LGQGLIQSAAK 3447
Query: 2826 ALPSED-EEGQDDKDFYLRGAVGLSGDHSA-LESQIRQLGK---ALDDSRFQIQQTENII 2880
+ ++ E DD + + +A L+ + G+ AL+ + TE ++
Sbjct: 3448 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3507
Query: 2881 RSKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST 2934
++ P E K +LL + S+++ +KR K+ E L
Sbjct: 3508 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL--- 3564
Query: 2935 ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE 2994
Q + + RWE L +A ++ +++ QQF+ L + WL E+ L +
Sbjct: 3565 -KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE--P 3621
Query: 2995 LSTDIQTIELQIKKLKELQ-KAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQMN 3052
+ T +E QI + K L+ ++H K + ++++ S+E +D+ Q +L
Sbjct: 3622 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQ 3680
Query: 3053 GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL 3112
+ + LLQ AL + F E L+ L + + +++ D E L
Sbjct: 3681 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD--YSTEGL 3738
Query: 3113 QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKE 3172
+L ++ ++L + V +LL G + L ++K+ I R K + K
Sbjct: 3739 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3798
Query: 3173 VSRHIKELEKLLDVS----SSQQDLSSWSSADELD-TSGSVSPTSGRSTPNRQKTPR 3224
+ K LE+ L ++ S+ ++L +W E++ S G Q P+
Sbjct: 3799 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3855
Score = 96.3 bits (238), Expect = 5e-19
Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)
Query: 1330 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 788 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 840
Query: 1387 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 1446
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 841 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 892
Query: 1447 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 1506
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 893 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 944
Query: 1507 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 1565
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 945 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 1002
Query: 1566 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 1623
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 1003 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 1055
Query: 1624 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 1678
+T + + +I + D +SH+ + I+ EA
Sbjct: 1056 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 1115
Query: 1679 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 1732
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 1116 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 1175
Query: 1733 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 1777
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 1176 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1235
Query: 1778 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 1817
Q++ EDR ++ +D + V I + L K L
Sbjct: 1236 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1294
Query: 1818 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 1877
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 1295 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1351
Query: 1878 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 1931
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 1352 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1411
Query: 1932 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 1980
+L + + + KE ++ L W + Q R L+ L
Sbjct: 1412 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1471
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 1472 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1527
Query: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1528 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1572
Query: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
+ E L V + Q + D ++ E+
Sbjct: 1573 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1608
Query: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 2216
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1609 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1662
Query: 2217 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 2274
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1663 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1710
Query: 2275 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 2330
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1711 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1762
Query: 2331 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 2376
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1763 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1822
Query: 2377 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 2429
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1823 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1882
Query: 2430 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 2454
SE A K ++ S EE Q LN+Q
Sbjct: 1883 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1942
Query: 2455 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 2509
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1943 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 2001
Query: 2510 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 2568
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 2002 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 2060
Query: 2569 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 2616
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 2061 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 2120
Query: 2617 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 2670
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 2121 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2178
Query: 2671 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 2728
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 2179 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2238
Query: 2729 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 2784
++KL ++ L R L ++D L W SL P S+ L
Sbjct: 2239 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2288
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 2843
+++ + E+ +S+++ ++ ++ M PS Q KD R
Sbjct: 2289 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2338
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 2903
+ S H +++ +L ++ ++ + + +KT E+D K +L
Sbjct: 2339 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2397
Query: 2904 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 2962
S LEHK E SL ++ H + A V+++ L + E +K+
Sbjct: 2398 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2455
Query: 2963 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 2999
++ F + S+ +W+ +T ++ LE ++L+ +
Sbjct: 2456 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2515
Query: 3000 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 3044
+T E+Q L L AV I ++ + + E T +++E +
Sbjct: 2516 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2575
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
+ ++ ++ ++ + LL++ L L + Q E S ++ L+ +++ +
Sbjct: 2576 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2635
Query: 3105 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 3164
+ D E ++ +Q + EL ++ +V L+D +LL E D EA
Sbjct: 2636 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2685
Query: 3165 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 3209
R K +L E+ +EL +L L+ SS+ + L W EL S +
Sbjct: 2686 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2744
Query: 3210 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 3269
P S PN T R + + + P LS PG S RG + L
Sbjct: 2745 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2802
Query: 3270 RA 3271
A
Sbjct: 2803 AA 2804
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 264 bits (675), Expect = 1e-69
Identities = 605/3391 (17%), Positives = 1312/3391 (38%), Gaps = 380/3391 (11%)
Query: 32 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 91
H+Q I Q + S + E +E+ +L+ +V GT N Q ++
Sbjct: 1714 HKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNLLETDVDGQV---GTTQENLNQQYQKVKA 1769
Query: 92 LHQTLLEESKEI---DSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRL 148
H+ ++ + + + + + EK S EK+ + + EL E + ++
Sbjct: 1770 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1829
Query: 149 QNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGR-------LSLKEQLSHRQHLLS 201
+ ++++KF+A+ + + L+Q++ L + E G LK Q S + ++S
Sbjct: 1830 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1889
Query: 202 EMESLKPKV----QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIM 257
L+ + ++ +S + V + R + A+ + +CN++
Sbjct: 1890 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1949
Query: 258 ----QAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRH--EELAQK 311
+ V +Y+ YE L + +Q +A S+H E +A
Sbjct: 1950 GNNLKDLVDKYQHYEDASCGL-----------------LAGLQACEATASKHLSEPIAVD 1992
Query: 312 IKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVM 371
K Q Q+ + ++ + ++ + V +++ AE D G LLP + +
Sbjct: 1993 PKNLQRQLEETKA------LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD 2046
Query: 372 MTAGRCHTLLSPVTEE------------SGEEGT--------NSEISSPPACRSPSPVAN 411
GR L V E S ++G N E S + P
Sbjct: 2047 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTA 2106
Query: 412 TDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETL 471
++++I Q ++ + +A ++ E +P S AK+ DL +
Sbjct: 2107 LQDIISKNIMLEQDIAGRQSSINA--MNEKVKKFMETTDPSTASSLQAKMKDLSARFSEA 2164
Query: 472 KNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALM 531
+ E + E + + +++ + + T +E L+E PG+ Q
Sbjct: 2165 SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQEST 2224
Query: 532 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMS-TIRMKASGKR- 589
E L + + E+ SL +E+ S +D A L + L+ + M TI+ K
Sbjct: 2225 SEFLEHKKHL-EVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2283
Query: 590 --------QLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPM 641
Q+L + L ++E ++ + + A++L L TK + E
Sbjct: 2284 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2343
Query: 642 DMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK-LRRLKGSL 700
+ + N++ + A++ +V + +L G+ + E A K L +K +
Sbjct: 2344 KVNNSGISLCNLISAVTTPAKAIA--AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDM 2401
Query: 701 LELQRALHDKQLNMQGTAQEKEE--SDVDLTATQSPGVQEWLAQARTTWTQQRQS----- 753
++ D L ++ E S + +S + +WL + T T+ +Q+
Sbjct: 2402 TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2461
Query: 754 ------SLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP-------- 799
++Q K E EL + + ++ + + E+L E + D E P
Sbjct: 2462 TEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL------EENPDTPEAPRWKQMLTE 2515
Query: 800 -DVLSQELGM-------EGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVL---------- 841
D QEL + E+SS E+ +++ +++L+ +VL
Sbjct: 2516 IDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNML 2575
Query: 842 --EQEQEQVL----------YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV 889
+++Q Q+L Y + G+ G+ P+ + V L + Q ++ +
Sbjct: 2576 NTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSL-RGIVKEQLAAVTQKWDSL 2634
Query: 890 SSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEIL 946
+ Q Q+I + + + S L D++ +L + A+ T NQ++
Sbjct: 2635 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV---STHPDAMNQQLE 2691
Query: 947 AKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL--SLLDSV--VNQRCHQ 1002
+ + +K + +QA E+ V E+ L L R +L S V Q+
Sbjct: 2692 TAQKMKQEIQQEKKQIKVAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAEN 2750
Query: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062
+ LQ + + + ++ +K P++ +++ ++ K+F
Sbjct: 2751 HVQHLQSACASSHQFQQMSRDF--QAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2808
Query: 1063 GIIELKRRGDKLQVEQPSMQ-------------ELSKLQDMYDELMMIIGSRRSGLNQNL 1109
+ +K E ++ +L+ ++ +D + R + L ++L
Sbjct: 2809 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2868
Query: 1110 TLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE--IQQLLDKHKEYFQGLESHMIL 1167
+Y+ ++ L ++ Q + + + ++ E I +L KE Q +L
Sbjct: 2869 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELL 2928
Query: 1168 TETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL 1225
T + + KE T + L+ + V ++ H + LE + + + E +E
Sbjct: 2929 NNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 2988
Query: 1226 SRQLEVVESSIP---SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
RQL+ + + S+G + L T+ Q + SL + ++ + L++
Sbjct: 2989 KRQLQCAKEQLDIHDSLGSQAYSNKYL----TMLQTQQKSLQALKHQVDLAKRLAQDLVV 3044
Query: 1283 SIS----CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSA 1338
S SD+ Q+ + + + + ++ ++ LET L+ +Q+ ++
Sbjct: 3045 EASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3104
Query: 1339 KDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-- 1396
D L+ V ++ E ++ F K+++A + + T +L ++
Sbjct: 3105 DDELD----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3160
Query: 1397 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQK 1456
D ++ +L + Q LL A +E++ + +L + S++ + L++ +
Sbjct: 3161 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT-IKRLEEFY--SKLKEFSILLQKAEEH 3217
Query: 1457 DEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESKRSD 1512
+E + + I++ L +K F+ + + KQ V+++ Q ++Q +++ ++ +
Sbjct: 3218 EESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLE 3277
Query: 1513 KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKRLKQ 1571
L +N W+ L V ++ L+ L +++ ++ L +W +T+E Q
Sbjct: 3278 -----HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ 3332
Query: 1572 QHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLREL 1631
+ + V+ +++ + L+ L+ ++ VE I++ G + + ++ L L
Sbjct: 3333 KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLL 3392
Query: 1632 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 1691
W L + L+ + + +N +L L + ++
Sbjct: 3393 DSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLE 3452
Query: 1692 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751
Q+ + L+DD+ + L + SI Q LK + + + + + W EI
Sbjct: 3453 EQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQVW---YIEI 3508
Query: 1752 AEQLQSSKALLQL--------------WQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 1797
E+ S LLQ + + S + Q+ T L K +
Sbjct: 3509 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3568
Query: 1798 IADDEVATWIQDCND-LLKGLGTVK----DSLFFLHELGEQLKQQ------VDASAASAI 1846
+ +++ Q+ + LL GL +K D + + + E +K + + A +
Sbjct: 3569 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3628
Query: 1847 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 1906
+ L L++ L + + LC ++ +L YET ++L+G++ S
Sbjct: 3629 EQ-ALQLARRLHSTHEELCTWLDKVEVELLSYET----------------QVLKGEEASQ 3671
Query: 1907 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL----PLNDKE--IKRMQNLNRH 1960
+ Q R +ELK + ++ LD LNE+ L P +E K + N
Sbjct: 3672 A------QMRPKELKKEAKNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAEDNER 3722
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQ 2018
+ L+S T++ ++ + +L+ Q F + + + ++ +TE+KL +I Q
Sbjct: 3723 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3782
Query: 2019 RAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
+ + F E+ + I+ ++ G +++ +++ KL + + + + +R
Sbjct: 3783 QVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3842
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV- 2137
++ ++ E E+L WL E + + +P P + TL + + ++
Sbjct: 3843 YLQLERAQSLVNQFWETYEELWPWLTETQSI----ISQLPAPALEYETLRQQQEEHRQLR 3898
Query: 2138 -FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM---RLEEQKKKLA 2193
+ + +I + LL G E IQEK+ +A +++E KK A
Sbjct: 3899 ELIAEHKPHIDKMNKTGPQLLELSPG-------EGFSIQEKYVAADTLYSQIKEDVKKRA 3951
Query: 2194 FLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLT 2253
L + D ++++ +++ + L + AE + KE + + + D+
Sbjct: 3952 VALDEAISQSTQFHDKIDQILESLERIVERLRQP-PSISAEVEKIKEQISENKNVSVDME 4010
Query: 2254 QLSLLKDTLS-------AYISADDISI----LNERVELLQRQWEELCHQLSLRRQQIGER 2302
+L L +TL A D I + ++++ + WE + + R ++ +
Sbjct: 4011 KLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4070
Query: 2303 LNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKD----YQEEIAIAQENKI 2358
+ F + L + + + D I+ + K +++ +EEI QE
Sbjct: 4071 MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELD 4130
Query: 2359 QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ +G L A E ++ + ++N W L R+ KL+E + A Q +
Sbjct: 4131 IVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4190
Query: 2419 SSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
++ W+ +LA PI D E +++++ E ++ + + + + + + E+
Sbjct: 4191 QAVFDWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL 4247
Query: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
LL +++ ++Q L W ++ + R+ K+E +F
Sbjct: 4248 LLKKV---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4304
Query: 2537 DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT 2596
WL +E + G + EL K Q V + +E +NK L +
Sbjct: 4305 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4364
Query: 2597 DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 2656
+ A +L+ + NQRW N+ ++ ++L + Q + F + + WLT+ + L
Sbjct: 4365 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4424
Query: 2657 NIEHFSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIEEEL 2713
+ AK +QL + + K E ++ +G+Q++ + I++++
Sbjct: 4425 ASKPLGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDI 4483
Query: 2714 DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL- 2772
+ L+ + V E L++R+ +LE++ L+ + +H+ D +
Sbjct: 4484 NNLKEKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQDFIN 4523
Query: 2773 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 2832
Q L+++ L +D++ + D + ++ S + + D+
Sbjct: 4524 WLTQAEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQIIEL-DK 4571
Query: 2833 EGQDDKDFYLRGAVGLSGD-----HSALESQIRQL---GKALDDSRFQIQQ--------T 2876
G K F + V L + S E +++L G++LDD+R + +Q
Sbjct: 4572 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4631
Query: 2877 ENIIRSKTPTGPELDTS------------YKGYMKLLGECSSSIDSVKRLEHKLKEEEES 2924
E + S+ EL+ + +K + K LG S D+ R LKE+
Sbjct: 4632 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
Query: 2925 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
+ L + + + D+W+ + +++ ++ ++++ L QF L ++ WL E
Sbjct: 4692 ADDNLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4748
Query: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 3044
+L + Q + DI + I K QK + R + + ++ + E + +S +
Sbjct: 4749 PQLAEDQPVH--GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4806
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVP 3102
+ ++ +++ RW+ VC+L + L+ AL Q + FH + H LL L ++ R + ++P
Sbjct: 4807 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4866
Query: 3103 IDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
D + L D HK+ M+ +L E + + M +L K + +I
Sbjct: 4867 DDEDA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4922
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 3193
R + +L +H + L L ++Q+L
Sbjct: 4923 RARFEEVLAWAKQHQQRLASALAGLIAKQEL 4953
Score = 253 bits (647), Expect = 2e-66
Identities = 639/3471 (18%), Positives = 1341/3471 (38%), Gaps = 495/3471 (14%)
Query: 23 KKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNS 82
+K +L E Q Q +NRL L L+ Y + + WI++ + I N
Sbjct: 1262 EKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET-TQRKIQENQ 1320
Query: 83 -------ASQLREQYIL------HQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ 129
A+QL +Q +L Q+ ++E ++ + A + + T Y SQQ
Sbjct: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
Query: 130 VAELGR------------ETEELR----QMIKIRLQNLQDAAKDMKKFEAE--------- 164
+ + R E +LR ++ + Q ++ A +K+ E E
Sbjct: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
Query: 165 -----LKKLQAALEQAQATLTSPE-VGRLSLKEQLSHRQHLLSEMESLKPKVQAVQL--- 215
K+LQ + TL E G+ +Q + + ++ E L +Q +QL
Sbjct: 1441 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1500
Query: 216 -----------------------------CQSALRIPE-----DVVASLPLCHAALRLQE 241
+S ++ E DV + A R QE
Sbjct: 1501 KHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI--VAERQQE 1558
Query: 242 EASRLQH------------TAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKP 289
+LQ Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + +
Sbjct: 1559 YKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVV 1618
Query: 290 VATSNIQELQAQISRHEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGL 348
T N + E+L+Q+ K EQ + KC+ L +KA+ + L +
Sbjct: 1619 KNTENFLK-----ENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1673
Query: 349 AEGTEDLDGELLPTPSAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGT-NSE 396
E TE + S S V + R T V E++G +EG S
Sbjct: 1674 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSA 1733
Query: 397 ISSPPACRS-------PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQE 447
I V T ++NQ YQ + A E++ + + +T ++Q
Sbjct: 1734 IGEEDEVNGNLLETDVDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQV 1790
Query: 448 FYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAI 506
E + + + LQ++ + LK YE AL +K S+ ++E
Sbjct: 1791 LLEKQGQYLSPEEKEKLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKF 1842
Query: 507 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS------------ 554
+ +E + E ++ +A D+I L ++ Q S +E+++S
Sbjct: 1843 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISG 1901
Query: 555 -------ESCEADPAEQLALQSTLTVLAERM--STIRMKA-SGKRQLLEEKLNDQLEEQR 604
+SC ++ +T + ++ +T R ++ K +L L D +++
Sbjct: 1902 NRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK-- 1959
Query: 605 QEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVV 662
Q Y + L + L + +AT LS P +P +++ QL + + + +I + V
Sbjct: 1960 ----YQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQV 2015
Query: 663 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE 722
A+ +L E +LL+ + + L + G +L ++++++ +Q
Sbjct: 2016 AVEKLKKTAE-VLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------- 2067
Query: 723 ESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSV 775
+T T+S VQ+ L + W +SSL++Q + L+ +++ L + +
Sbjct: 2068 -----ITLTRSLSVQDGLDE-MLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 2121
Query: 776 ASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESL--HQEFSTK 833
A R I + + + + S + M+ + + E+L +E TK
Sbjct: 2122 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 2181
Query: 834 QKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQS 893
+L +N+ E+ Q + L+ V DVP +D + L+Q +E +S+
Sbjct: 2182 VELFENL--SEKLQTFLETKTQALTEV-----DVPGKD-------VTELSQYMQESTSEF 2227
Query: 894 GGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEM 953
K+ L L + +++ LP + L L+K KEM
Sbjct: 2228 LEHKKHLEVLHSLLKE-----------------ISSHGLPSDKALVLEKTNNLSKKFKEM 2270
Query: 954 SEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQIL 1011
+ + + K + E D V+ +L + + +V + + L+
Sbjct: 2271 EDTIKEKKEAVTSC-QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTK 2329
Query: 1012 NFQN--DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKR 1069
Q LK +N I L L + P A+ I A++ +G L
Sbjct: 2330 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNG 2378
Query: 1070 RGDKLQVEQ--------PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQ 1120
G E+ ++++ + Y++L +++ + + LN L+ L+ E +
Sbjct: 2379 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSA 2438
Query: 1121 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHM--------ILTETLF 1172
+ L + + Q + E ++ ++++K + L+ ++ LTE L
Sbjct: 2439 MMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLE 2498
Query: 1173 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV 1232
+ + Q TE+ ++ + + R +LE + + +L + L
Sbjct: 2499 ENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEK 2558
Query: 1233 ESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---- 1288
E + +G + + + L + Q L +P+ Q+ G+ +L S D
Sbjct: 2559 ELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLR 2617
Query: 1289 --LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
++ QL + + W S T ++S ++ + T+YQS L+ L L+
Sbjct: 2618 GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQS----LLRSLSDKLSDLDNKL 2673
Query: 1347 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELS 1406
S+ V + + L + +E+ + + L L K + L++ELS
Sbjct: 2674 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE--YLKAELS 2731
Query: 1407 RIDSQWTDLLTNIPAVQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDED 1459
R Q +L + V++K Q S H ++ +W+ +K+E
Sbjct: 2732 R---QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD-----TKKEEQ 2783
Query: 1460 NIKNSIGYK--AIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 1517
N + I K + ++ +K F + + +++ + + ++++ S+K
Sbjct: 2784 NKSHPISAKLDVLESLIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQ 2840
Query: 1518 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 1577
QL + +W V E+ L+ LE +Y+ V+ L W + + L++ D
Sbjct: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
Query: 1578 QASVQNALKDCQDLE------------------DLIKAKEKEVEKIEQNGLALIQNKKED 1619
A +N++ + L+ L+ E + E + +LIQ K +
Sbjct: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDM 2959
Query: 1620 VSSIVMS---TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYS 1676
V+ + S L + Q + + + K L+ +Q H D + S +Y
Sbjct: 2960 VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY- 3014
Query: 1677 LSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLL 1722
L+ + SL+A++ QVD + L DL + E Q+ +++ Q+
Sbjct: 3015 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3074
Query: 1723 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 1782
++C L L+ + N + E ++ + L + +D A T+Q+Q
Sbjct: 3075 EKC-----SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQ 3124
Query: 1783 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
++ LK ++D + C +L T D +
Sbjct: 3125 KETIKAFLKKLEALMASNDNAN---KTCKMMLATEETSPDLV------------------ 3163
Query: 1843 ASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
I+ D +LS+ L ++ ++ + E F L+ + +AEE + Q
Sbjct: 3164 --GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQ 3221
Query: 1903 DPSHSSDLSTIQERMEELK-GQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL---- 1957
P + TI +++ K Q + + +N LG L + + Q L
Sbjct: 3222 GPV-GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL 3280
Query: 1958 ---NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQ 2012
N W ++ + +R ++LQ LL F + E+ + ++V TE+ +A + S ++
Sbjct: 3281 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3340
Query: 2013 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 2072
+ Q + +L Q + R+ + I +G+++ + D+ + +L+LL ++W+ ++
Sbjct: 3341 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3400
Query: 2073 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 2132
+A+ R ++ Q++ E E L +WL + + PI Q ++ Q
Sbjct: 3401 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIE---KRLVNCEPIGTQASKLEEQIAQ 3457
Query: 2133 FK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASM 2183
K E + V G+ L + + + +Q++L EIQEK S S
Sbjct: 3458 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3517
Query: 2184 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEE-LHAEQMRCKELE 2242
L++ +D E + + L ++ KL S+ D+ E L +Q + L+
Sbjct: 3518 LLQQALCNAKIFGED----EVELMNWLNEVHDKLSKL--SVQDYSTEGLWKQQSELRVLQ 3571
Query: 2243 NAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGER 2302
+ ++ Q L L + D++ I+ +++E ++ +++++ + + + +
Sbjct: 3572 EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQA 3631
Query: 2303 LNEWAVFSEKNKELCEWLTQMESK-VSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQ 2361
L ++ELC WL ++E + +S +L E + + +E A+ NK L
Sbjct: 3632 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD 3691
Query: 2362 QMGE---RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ E L + +E + + N+R++ + D I +V+++ ++ QQ D+
Sbjct: 3692 SLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAA 3751
Query: 2419 SSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL 2478
+ +W+ E +L + ++ +L Q+ +I +H + ++ ++
Sbjct: 3752 DAELSWITETEKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM 3810
Query: 2479 HDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 2538
C ++ E S+++ + + + IC ++ ER L++E L +F + Y W
Sbjct: 3811 TAC----SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866
Query: 2539 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 2598
L ++ + + + Y +++ ++ + + E ++ +NK +L E
Sbjct: 3867 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGE 3925
Query: 2599 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 2658
S+++ + + +++ V L I Q +F D IL L + +L
Sbjct: 3926 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3985
Query: 2659 EHFSECDVQAKIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIE 2710
S +V+ KIK+ + + +S++ K+ E + +GE++I +S + + A ++
Sbjct: 3986 PSIS-AEVE-KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
Query: 2711 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 2770
++LD++ + + VE +RE +L D L++ W D +
Sbjct: 4044 DKLDQMVFIWENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS- 4083
Query: 2771 SLLSPQPSSNLSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAM 2823
+++ + + + L P ++ ++ +T +D + E D +L +L +A
Sbjct: 4084 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC 4143
Query: 2824 SRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIR-QLGKALDDSRFQIQQTENI--- 2879
G+ DK + L+ +L + ++ K + + +Q + +
Sbjct: 4144 ----------GEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4193
Query: 2880 ----------IRSKTPTGPELDT---SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 2926
+ S +P G +L+T + + E ++RL H+ + + +
Sbjct: 4194 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4253
Query: 2927 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 2986
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE
Sbjct: 4254 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4313
Query: 2987 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQ 3045
L ++ + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ
Sbjct: 4314 LS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ 4371
Query: 3046 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 3105
++L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 4372 NKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGG 4431
Query: 3106 ---------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 3150
N+ E+ ++ +K LMQ ++L + S + ++ +
Sbjct: 4432 LPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDIN 4484
Query: 3151 DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 3201
+ E E V N K L+E L ++ +S QD +W + E
Sbjct: 4485 NLKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4529
Score = 244 bits (624), Expect = 8e-64
Identities = 429/2257 (19%), Positives = 899/2257 (39%), Gaps = 262/2257 (11%)
Query: 37 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK----------VLAHGTIAWNSASQL 86
+Q + R +KL ++ +Y E +E + WI+K + A G + L
Sbjct: 2855 KQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSL 2914
Query: 87 REQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKI 146
+++ H ++E + L ++ E + T++ + ++ TE+L K
Sbjct: 2915 QKEMDQHFGMVELLNNTANSLLSVCE----IDKEVVTDENKSLIQKVDMVTEQLHSK-KF 2969
Query: 147 RLQNLQDAAKDMKKFEAELKK-LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMES 205
L+N+ K+ ++ E K+ LQ A EQ + + + L+ Q +++
Sbjct: 2970 CLENMTQKFKEFQEVSKESKRQLQCAKEQLD--IHDSLGSQAYSNKYLTMLQTQQKSLQA 3027
Query: 206 LKPKVQ-AVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 264
LK +V A +L Q + D + + + +E S L ++C+ ++ +
Sbjct: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3087
Query: 265 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 324
++ ++ + E++ + + LQ Q + +K++ + N
Sbjct: 3088 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3147
Query: 325 KCKMLTMKAKHATMLLTV-TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSP 383
CKM+ + + L+ + ++E L++ +LL A V T R S
Sbjct: 3148 TCKMMLATEETSPDLVGIKRDLEALSKQC----NKLLDRAQAREEQVEGTIKRLEEFYSK 3203
Query: 384 VTE-----ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 438
+ E + EE S+ PV ++NQ + ++ E ++ K
Sbjct: 3204 LKEFSILLQKAEEHEESQ----------GPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3253
Query: 439 HPSTSASQEFYEPGLEPSATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
Q + + ++T L D+ W+TL ++++ L EAL ++QD
Sbjct: 3254 QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQD 3313
Query: 495 SLQS-ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELV 553
+L+S +S ++ EL ++ P P ++ +A + E +LQ +++ +S++ E++
Sbjct: 3314 ALESLLSWMVDTEELVANQKP-----PSAEFKVVKAQIQEQKLLQRLLDDRKSTV--EVI 3366
Query: 554 SESCE-----ADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE-------------EK 595
E A+PA+++ + L++L R + KA + + LE E
Sbjct: 3367 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3426
Query: 596 LNDQLE--EQR---------QEQALQRYRCEADELDSWLLSTKATLDTALS--------P 636
LN+ L E+R Q L+ + L+ +++ L A+S
Sbjct: 3427 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLS 3486
Query: 637 PKEPMDMEAQLMD-CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE------QL 689
+E DM +D Q +EI++K + SEL + L K +DE E ++
Sbjct: 3487 SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL---QQALCNAKIFGEDEVELMNWLNEV 3543
Query: 690 AGKLRRL-------------KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGV 736
KL +L + L LQ + ++ N+ E T + +
Sbjct: 3544 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3603
Query: 737 QEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAG 796
Q+ L + + + S K LEQ L L R + S EE+ E
Sbjct: 3604 QDKLEAIKARYKDITKLSTDVAKTLEQAL----QLARRLHSTHEELCTWLDKVEV----- 3654
Query: 797 EKPDVLSQELG-MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 855
++LS E ++GE++S Q +M+ + L +E + LL + L + +L P R
Sbjct: 3655 ---ELLSYETQVLKGEEAS---QAQMRPKELKKEAKNNKALLDS-LNEVSSALLELVPWR 3707
Query: 856 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 915
G+ + +D + D + Q EE+ + +I Q+ A
Sbjct: 3708 AREGLE----KMVAEDNERYRLVSDTITQKVEEIDA--------AILRSQQFDQAADAEL 3755
Query: 916 TWLDDVEERLFVATALLPEETETC-------LFNQEILAKDIKEMSEEMDKNKNLFSQAF 968
+W+ + E++L + E+ +T F EIL K++ +++ K+ + A
Sbjct: 3756 SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH--KDIIDDLVKSGHKIMTAC 3813
Query: 969 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN-FQNDLKVLFTSLADN 1027
E + + ++ L +L + + ++R Q+ ER Q ++N F + L+ L +
Sbjct: 3814 SE--EEKQSMKKKLDKVLKNYDTICQINSERYLQL-ERAQSLVNQFWETYEELWPWLTET 3870
Query: 1028 KYIILQKLANVFE-QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP----SMQ 1082
+ II Q A E + + +Q E +Q + + E I ++ + G +L P S+Q
Sbjct: 3871 QSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQ 3930
Query: 1083 ELSKLQD-MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 1141
E D +Y ++ + R L++ ++ +Q+ + + + LE E++ I
Sbjct: 3931 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSIS 3989
Query: 1142 SSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRA 1201
+ E+I++ + ++K +E L ETL Q E++A++ K
Sbjct: 3990 AEVEKIKEQISENKNVSVDMEKLQPLYETL------------KQRGEEMIARSGGTDKDI 4037
Query: 1202 HKRGVE--LEYILETWSHL----DEDQQELSRQLEVVE-------SSIPSV----GLVEE 1244
+ V+ L+ ++ W ++ +E + +L +E+ E S I ++ + +
Sbjct: 4038 SAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD 4097
Query: 1245 NEDRLIDRITLYQH------LKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQ 1295
ED ID + Q ++ ++ Q +L V++ G L+ + D ++ +++
Sbjct: 4098 LEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDE 4157
Query: 1296 LGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQE 1355
L W S + +LE ++ +YQ + W+ A +L + + +
Sbjct: 4158 LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----PIGTD 4213
Query: 1356 LEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV----DTATLRSELSRIDSQ 1411
LE V+ + +F E Q ++ L+ +LL LKKV D T++ L +
Sbjct: 4214 LETVKQQIEELKQFKSEA-YQQQIEMERLNHQAELL-LKKVTEESDKHTVQDPLMELKLI 4271
Query: 1412 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--YKA 1469
W L I Q KL + +HA+ E+++W++ E ++ + + +G KA
Sbjct: 4272 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-----QKPVGGDPKA 4326
Query: 1470 IHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK-TDFAEQLGAMNKSWQ 1528
I L K+ + D+ Q TV+ VN++ + +ES ++ ++ +L +N+ WQ
Sbjct: 4327 IEIELAKHHVLQNDVLAHQSTVEAVNKA----GNDLIESSAGEEASNLQNKLEVLNQRWQ 4382
Query: 1529 ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNALKD 1587
+ ++ Q L+G L + ++ L+ W E+ L +G + + L
Sbjct: 4383 NVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4442
Query: 1588 CQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKI 1647
++ +AKE+ + + Q G ++ + + + + L + W +++ + + K
Sbjct: 4443 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4502
Query: 1648 LLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 1707
L+ L+ + ++L +A +L+ + L+ V Q+D + +++
Sbjct: 4503 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4562
Query: 1708 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS-------SKA 1760
+ + L + N L V RW +++ + E+ +S +K
Sbjct: 4563 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4622
Query: 1761 LLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTV 1820
+ W + ++ ++ ++ + + N+ D++ T + + K LG
Sbjct: 4623 FHEAWSKLMEWLEESEKSLDSELEIAND-----------PDKIKTQLAQHKEFQKSLGAK 4671
Query: 1821 KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE---QALC----KQQTSLQA 1873
+ G LK++ +++ D L L L L +C ++Q L+
Sbjct: 4672 HSVYDTTNRTGRSLKEK------TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4725
Query: 1874 GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 1933
+L F +L+AL W+ E L P H D+ + ++ K +
Sbjct: 4726 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSS 4784
Query: 1934 LDRLNELGYRLPLNDKEIK-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 1988
+ L L ++ +MQ L+ W + + + + ++L++ L Q + F
Sbjct: 4785 VQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV 4844
Query: 1989 CETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL 2046
+E+L + EQ L + + L H+ F ++ ++ L+ G +L
Sbjct: 4845 VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4904
Query: 2047 EQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV-E 2105
D +T++ +++ V+ A+Q + + S + +E+ E L WL
Sbjct: 4905 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 4964
Query: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQ-FKEKVFLRQ 2141
+ L +P +++ + L E Q F E++ +Q
Sbjct: 4965 ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5001
Score = 230 bits (587), Expect = 2e-59
Identities = 557/3213 (17%), Positives = 1245/3213 (38%), Gaps = 497/3213 (15%)
Query: 264 YEQYEQEMKHLQQLIEGAH----REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQI 319
Y Y E+++++ +E R+I P+ ++ E +I+ E+L ++++ ++ +
Sbjct: 1065 YNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDLHESVFRITEQEKLKKELERLKDDL 1123
Query: 320 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 379
++ +KC+ +A ++ + PT + +VV+ + ++
Sbjct: 1124 GTITNKCEEFFSQAAASSSV---------------------PTLRSELNVVLQNMNQVYS 1162
Query: 380 LLSP----------VTEESGEEGTNSEISSPPACRSPSPVANTDASVN--QDIAYYQALS 427
+ S V + + ++ C + +A+ + N + +++
Sbjct: 1163 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV 1222
Query: 428 AERLQTDAA---KIHPSTSASQEFYEPGLEPSAT-----AKLGDLQRSWETLKNVISEKQ 479
E+ Q A ++ + + S E ++ E K L W+ + I +
Sbjct: 1223 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1282
Query: 480 RTLYEALERQQKYQDSLQSISTKMEAIEL---KLSES-PEPGRSPESQMAEHQALMDEIL 535
R L + + Y+D+ + ++ +E K+ E+ PE ++ +Q+ + + L+ EI
Sbjct: 1283 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1342
Query: 536 MLQDEINELQS---------------SLAEELVSESCEADPAEQLALQSTLTVLAERMST 580
M Q +++E Q ++ + +S + P ++ +QS+ ++ +
Sbjct: 1343 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1402
Query: 581 IRMKASGKRQLLEEKLN---DQLEE-QRQEQALQRYRCE----ADELDSWLLSTKATLDT 632
+R + + L+ + + D L+ + +E++L+ + E A EL W+ + TL
Sbjct: 1403 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1462
Query: 633 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 692
A K P Q + + + + EQ AL + + L G T +E +L +
Sbjct: 1463 AEKAGKPP--FSKQKISSEEISTKKEQLSEALQTIQLF---LAKHGDKMTDEERNELEKQ 1517
Query: 693 LRRLKGS----LLELQRALHDKQLNMQGTAQEKEESDVD-------------LTATQSPG 735
++ L+ S E + L + Q + +EK ++ LT T++
Sbjct: 1518 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1577
Query: 736 VQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 795
+ A T + + +Q+EL++++ L V E L ++
Sbjct: 1578 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN--------- 1628
Query: 796 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQ--KLLQNVLEQEQEQVLYSRP 853
GEK LSQE E+ E +++ + +L E S K+ K++ +++E E+V +
Sbjct: 1629 GEK---LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1685
Query: 854 NRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSA 913
+ K+ + +LLD L+ + S+ G K + + +
Sbjct: 1686 LE--------------ESKTKIENLLDWLSNV--DKDSERAGTKHKQV---------IEQ 1720
Query: 914 TSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD 973
T + + + + + EE E N +L D+ + +NL Q
Sbjct: 1721 NGTHFQEGDGK-----SAIGEEDEV---NGNLLETDVD--GQVGTTQENLNQQYQKVKAQ 1770
Query: 974 NRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLF-TSLADNKYIIL 1032
+ +I ++ S + Q + E +++ +LKV + T+LA+++
Sbjct: 1771 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESE---- 1826
Query: 1033 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 1092
++++ ++ L++FDA E + LQ + ++ L D +
Sbjct: 1827 ------------KKMKLTHSLQEELEKFDADYTEFEH---WLQQSEQELENLEAGADDIN 1871
Query: 1093 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQ--EKMAGDQKIIVSSKEEIQQL 1150
LM + ++S ++ K +LE + K G + ++ E+Q+
Sbjct: 1872 GLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRK 1931
Query: 1151 LDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEY 1210
LD + F+ L S + + ++ Q L+A A A K
Sbjct: 1932 LDHATDRFRSLYSKCNVLGNNLKDLVD-KYQHYEDASCGLLAGLQACEATASK------- 1983
Query: 1211 ILETWSHLDE----DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 1266
HL E D + L RQLE ++ + + ++L + + SL
Sbjct: 1984 ------HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPA 2037
Query: 1267 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 1326
+ + + LDD I DL +N+ E +L+ L Q
Sbjct: 2038 KNDIQKTLDD-----IVGRYEDLSKSVNERNE--------------KLQITLTRSLSVQD 2078
Query: 1327 ESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
+++ W+ + + L ++ VP ++D ++ + +++ + S ++
Sbjct: 2079 GLDEMLDWMGNVESSL----KEQGQVPLNSTALQDIISKNIMLEQDIAG----RQSSINA 2130
Query: 1387 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 1446
N+ ++KK T S S + ++ DL K H+ + K+ E+ +
Sbjct: 2131 MNE--KVKKFMETTDPSTASSLQAKMKDLSARFSEASHK-HKETLAKM------EELKTK 2181
Query: 1447 ISLMENVIQKDEDNIKN--------SIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ L EN+ +K + ++ + K + E Q + + + ++ ++ +
Sbjct: 2182 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 2241
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 1558
+ISS + SDK E+ ++K ++ ++ + EK + + E ++ V+ L
Sbjct: 2242 KEISSHGLP---SDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2298
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL------ 1612
K+W + K++ + +L+D + L++ K E++K+ +G++L
Sbjct: 2299 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2358
Query: 1613 IQNKKEDVSSIVM--------STLRELGQTWAN------------LDHMVGQLKILLKSV 1652
+ + ++++ T + WAN + H L +LLK
Sbjct: 2359 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2418
Query: 1653 LDQWSSHKVAFDK-------INSYLMEARYSLSRFRLLTG--SLEAVQVQVDNLQNLQDD 1703
+ + ++ K + +L + + ++++ EAV+ QV+ ++ + +
Sbjct: 2419 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2478
Query: 1704 LEKQERSLQKFGSITNQLLKE-CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALL 1762
L++ +Q+ +LL+E P L E++ +W L + ++ Q +
Sbjct: 2479 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2538
Query: 1763 QLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKD 1822
+++ Q + ++E + L + + ++ + T Q LL+ T K
Sbjct: 2539 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN----TQRQQVQILLQEFATRKP 2594
Query: 1823 SLFFLHELGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYET 1880
L G+ + + D S ++ +++Q +L L + + ++
Sbjct: 2595 QYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ 2654
Query: 1881 FAKSLEALEAWIVEAEEILQG------QDPSHSSDLSTIQERMEEL---KGQMLKFSSMA 1931
+ L +L + + + L + + L T Q+ +E+ K Q+ ++
Sbjct: 2655 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC 2714
Query: 1932 PDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL---QHQTFLEK 1988
DL L + Y L + ++++ + + + + + LQS Q Q
Sbjct: 2715 EDLSALVKEEY---LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2771
Query: 1989 CETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ 2048
+ W++ + EQ + IS L + H+ F + ++ + I +G+ LL +
Sbjct: 2772 FQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2830
Query: 2049 GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKW------ 2102
Q ++ L+L + W ++ ++R + + + +Y+E E L W
Sbjct: 2831 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2890
Query: 2103 -LVEVSYL--PMSG-----------------LGSVPIPLQQARTLFDEVQFKEKVFLRQQ 2142
L E+ + P G G V + A +L + ++V +
Sbjct: 2891 NLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN 2950
Query: 2143 GSYILTVE------------------------------------AGKQLLLSADSGAEAA 2166
S I V+ A +QL + G++A
Sbjct: 2951 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3010
Query: 2167 LQAELAEIQEKWKS--ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK---LS 2221
L +Q + KS A + K+LA L KG +D L ++ T ++ LS
Sbjct: 3011 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3070
Query: 2222 QSLPDHHEELHAE-------QMRCKELENAVGSWTDDLTQLSLL----------KDTLSA 2264
Q + + L + Q +E+ + + D+L ++ + K+T+ A
Sbjct: 3071 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3130
Query: 2265 YI-------------------------SADDISILNERVELLQRQWEELCHQLSLRRQQI 2299
++ ++ D+ + +E L +Q +L + R +Q+
Sbjct: 3131 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3190
Query: 2300 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQ 2354
+ F K KE L + E G + I + + K +EEI Q
Sbjct: 3191 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3250
Query: 2355 ENKIQLQQMGERLAKASHESKASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ 2413
+ + +G+ L +++ +S +++ +E+ L VN RW+ L +A R +L+E L+ +
Sbjct: 3251 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3310
Query: 2414 LDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
+ SL +W+ E +A KP S + ++ ++ EQ+ LQR ++ + V
Sbjct: 3311 FQDALESLLSWMVDTEELVANQKP---PSAEFKVVKAQIQEQKLLQRLLDDRKSTV---- 3363
Query: 2472 NLCEVLLHDCDACATDAE-CDSIQ--QATRNLDRRWRNICAMSMERRLKIEETWRLWQKF 2528
EV+ + + AT AE D ++ + LD RW + + R ++E + Q+F
Sbjct: 3364 ---EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3420
Query: 2529 LDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV---HECLTQLELINK 2585
+ +WL + E+ G + +E++ + +A + + ++ L Q I +
Sbjct: 3421 HETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ 3480
Query: 2586 QYRRLARENRTDSACSLKQMVHEGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSI 2644
+ L+ D + Q + +Q W +Q++ S L+ + + F +
Sbjct: 3481 SLKVLSSREDKD----MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVEL 3536
Query: 2645 LVWLTEMDLQLT--NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 2702
+ WL E+ +L+ +++ +S + + +L+ Q++I L ++Q + G +L++++
Sbjct: 3537 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTT 3596
Query: 2703 PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDL 2762
+ II+++L+ ++ +++ L D ++ L+L + L
Sbjct: 3597 GDEVLIIQDKLEAIKARYKDI-------------TKLSTDVAKTLEQALQL--ARRLHST 3641
Query: 2763 H-----WHDRSADSLLSPQ----PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 2813
H W D+ LLS + S + +P ++ ++ A +DS+
Sbjct: 3642 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL-------- 3693
Query: 2814 DLSRDLESAMSRALPSEDEEG-----QDDKDFYLRGAVGLSGDHSALESQI---RQLGKA 2865
++ SA+ +P EG +D + Y + ++ +++ I +Q +A
Sbjct: 3694 ---NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3750
Query: 2866 LDDSRFQIQQTENIIRS-------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
D I +TE + S + T +L M++L ID + + HK+
Sbjct: 3751 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDLVKSGHKI 3809
Query: 2919 ----KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLN 2974
EEE+ S + + V+ ++ + + L++++ QF
Sbjct: 3810 MTACSEEEK--------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3861
Query: 2975 SIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFT 3034
+W WL +T+ + QL L + +T+ Q ++ ++L++ + K I +N P+
Sbjct: 3862 ELWPWLTETQSIISQLPAPAL--EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3919
Query: 3035 QADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 3094
+ E +Q++ + + ++ +++ L +A+ Q FH+ +L LE I
Sbjct: 3920 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 3979
Query: 3095 RRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE 3154
R + P + + E +++ + + ++ + Q +L+ +++ + GTD
Sbjct: 3980 ERLRQ--PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI 4037
Query: 3155 AKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDV 3186
+ + V +++ + + + ++E E KLLDV
Sbjct: 4038 SAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4070
Score = 210 bits (534), Expect = 2e-53
Identities = 462/2514 (18%), Positives = 971/2514 (38%), Gaps = 299/2514 (11%)
Query: 21 LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 80
L++++ + + + ++AEN + L A + ++ +M W++ K
Sbjct: 2730 LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQ 2783
Query: 81 NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEEL 140
N + + + + ++L+++ K+ L A + ++ E + + G E L
Sbjct: 2784 NKSHPISAKLDVLESLIKDHKDFSKTLTAQS----HMYEKTIAEGENLLLKTQGSEKAAL 2839
Query: 141 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLL 200
+ + N K +K+ E KL+ +LE+A L KEQ+ + L
Sbjct: 2840 QLQLNTIKTNWDTFNKQVKERE---NKLKESLEKA-----------LKYKEQV---ETLW 2882
Query: 201 SEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------ 254
++ + ++ ++ C E+ +A L LQ+E QH + +
Sbjct: 2883 PWIDKCQNNLEEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTAN 2933
Query: 255 NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEE 307
+++ + E E K L Q ++ ++ K N+ QE+ + R +
Sbjct: 2934 SLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ 2993
Query: 308 LAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLA--------------EGTE 353
A++ + + S K LTM L + LA +GT
Sbjct: 2994 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTS 3053
Query: 354 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSP 408
D+ ++ H ++ +C L + + + T E+ S A S +P
Sbjct: 3054 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3113
Query: 409 VANTDASVNQD----IAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL 464
V ++ + A+ + L A D A + E P L L L
Sbjct: 3114 VGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL-VGIKRDLEAL 3172
Query: 465 QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---E 521
+ L + ++ + ++R +++ L+ S I L+ +E E + P E
Sbjct: 3173 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGME 3227
Query: 522 SQMAEHQALMDEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLA 575
++ Q M ++ ++EI LQ L + L+ + ++ + L+ L +
Sbjct: 3228 TETINQQLNMFKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVN 3284
Query: 576 ERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALS 635
R T+ K + + L+E L L R + AL + L SW++ T+ +
Sbjct: 3285 ARWKTLNKKVAQRAAQLQEAL---LHCGRFQDAL-------ESLLSWMVDTEELVANQKP 3334
Query: 636 PPKEPMDMEAQ---------LMDCQNMLVEI--------------EQKVVALSELSVHNE 672
P E ++AQ L+D + VE+ KV L +LS+ +
Sbjct: 3335 PSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3394
Query: 673 NL-LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLT 729
L KA T++ R+L+G + Q+ H+ + LN T EK + +
Sbjct: 3395 RWEALLNKAETRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPI 3444
Query: 730 ATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA- 788
TQ+ ++E +AQ + + K L Q ++ +S L+ ++SR ++ ++Q
Sbjct: 3445 GTQASKLEEQIAQHKAL----EDDIINHNKHLHQAVSIGQS-LKVLSSREDKDMVQSKLD 3499
Query: 789 ------AETSGDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFST 832
E + + ++L Q L K ED++ M W +H Q++ST
Sbjct: 3500 FSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST 3557
Query: 833 KQK-LLQNVLEQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEE 888
+ Q+ L QE +L + N LL+G+ L K + + L+ + +++
Sbjct: 3558 EGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKD 3616
Query: 889 VSSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQ 943
++ S + Q++ L ++L+ TWLD VE L + L EE
Sbjct: 3617 ITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP 3676
Query: 944 EILAKDIKEMSEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVV 996
+ L K+ K +D + N S A E G + V ED R L+ +
Sbjct: 3677 KELKKEAKNNKALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTI 3730
Query: 997 NQRCHQMKERLQQILNFQN--DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAE 1054
Q+ ++ + + F D ++ + + + K + L + +Q A+
Sbjct: 3731 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3790
Query: 1055 DGLKEFDAGIIELKRRGDKL------QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN 1108
+ L+ D I +L + G K+ + +Q ++L K+ YD + I R L +
Sbjct: 3791 EILRHKDI-IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERA 3849
Query: 1109 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILT 1168
+L +Q+ ++L L T + + E ++Q ++H++ + + H
Sbjct: 3850 QSLVNQFWETYEELWPWL-TETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 3908
Query: 1169 ETLFR---KII------SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLD 1219
+ + + +++ F++Q++ L +Q +K KR V L+ + +
Sbjct: 3909 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK---KRAVALDEAISQSTQFH 3965
Query: 1220 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 1279
+ ++ LE + + + +++ ++I+ +++ + + QP LY+ L
Sbjct: 3966 DKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQP-LYETLKQRGE 4024
Query: 1280 LLIS--------ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 1331
+I+ IS ++ +L+Q+ W + + + +L +++ ++ + L
Sbjct: 4025 EMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4084
Query: 1332 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 1391
I ++ +D + + + +V+ A +E+D V++ G++L+
Sbjct: 4085 IVTIKDTQDFIRDLEDPGI----DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4140
Query: 1392 -RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM 1450
+ D ++ + ++S W L +KL + + + + V W+ +
Sbjct: 4141 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4200
Query: 1451 ENVIQKDEDNIKNSIG--YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 1508
+ + IG + + + +++ K FK + +Q+ ++ +N + + E
Sbjct: 4201 GGKLAS-----MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE- 4254
Query: 1509 KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 1568
SDK + L + W L+ + + LEG L + ++++ + L W E
Sbjct: 4255 -ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4313
Query: 1569 LKQQHRI-GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 1627
L +Q + GD +++ L L++ + A + VE + + G LI++ + +S + +
Sbjct: 4314 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4373
Query: 1628 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSL 1687
L L Q W N+ Q K L L Q + + +L + L + L G
Sbjct: 4374 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4433
Query: 1688 EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNL 1747
E + Q++ + E +E + + Q+L C + + + +W ++
Sbjct: 4434 ETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4493
Query: 1748 LEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWI 1807
++ E+ + L L + + + + + Q E + L A+ + D V I
Sbjct: 4494 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE----QTLNVASRPSLILDTVLFQI 4549
Query: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
+ + + ++ + L + G LK I++ +S+ + Q L ++
Sbjct: 4550 DEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4609
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
SL + F ++ L W+ E+E+ L + ++D I+ ++ + K
Sbjct: 4610 GRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD-SELEIANDPDKIKTQLAQHKEFQKSL 4668
Query: 1928 SSMAPDLDRLNELGYRL----PLNDKEIK---RMQNLNRHWSLISSQTTERFSKLQSFLL 1980
+ D N G L L D +K + L W I ++ ER +KL+ LL
Sbjct: 4669 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSI 2038
F + + +++L + E +LA + + G+ ++ H+ FQ E+ R + ++
Sbjct: 4729 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL 4788
Query: 2039 IIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
+ L+E G DD +++ LS +W+ V + ++ +++ +RQ + + +
Sbjct: 4789 KRSARELIE-GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4847
Query: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158
L +WL E + G +P RTL D+ + K ++ G +L
Sbjct: 4848 LLEWLAEAEQ-TLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI 4906
Query: 2159 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF----LLKDWEKCEKGIADSLEKLR 2214
+ ++ + I+ +++ ++ +++LA L+ E E +A
Sbjct: 4907 CHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAET 4966
Query: 2215 TFKKKLSQSLPDHHEELHA---------EQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
T K + +P EE+ A E+M K+ + V T + + +L ++
Sbjct: 4967 TLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPD--VDKVTKTYKRRAADPSSLQSH 5024
Query: 2266 I----------------------SADDISILNERVELLQRQWEELCHQLSLRRQQIG--- 2300
I S I N RV LL +W+++ RR+++
Sbjct: 5025 IPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDAL 5084
Query: 2301 ---ERLNEWAVFSEK--NKELCEWLTQMESKV---------SQNGDILIEEMIE 2340
E L E+A F K+ W+ +S+V Q+G I +E I+
Sbjct: 5085 DRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFID 5138
Score = 203 bits (516), Expect = 3e-51
Identities = 501/2642 (18%), Positives = 1024/2642 (38%), Gaps = 403/2642 (15%)
Query: 2 ELDAAVQKFLEQNGQLGKP---LAKKIGKLTELHQQTIRQAENRLSKLNQAAS------- 51
+L A QK+ GQL + + I K T+ +Q +R ++LS L+ S
Sbjct: 2623 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ-YQSLLRSLSDKLSDLDNKLSSSLAVST 2681
Query: 52 HLEEYNEMLELILKWI-----EKAKVLAHGTIAWNSASQLREQYILHQT------LLEES 100
H + N+ LE K EK ++ + + ++ ++E+Y+ + +L+
Sbjct: 2682 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSF 2741
Query: 101 KEIDSELEAMTEKLQYLTSVYCTEKMSQQVA-------ELGRETEELRQMIKIRLQNLQD 153
K+++ + E +Q+L S + QQ++ + +E + I +L L+
Sbjct: 2742 KDVEQKAE---NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLES 2798
Query: 154 AAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV 213
KD K F K L A + T+ E L LK Q S + L ++ ++K
Sbjct: 2799 LIKDHKDFS---KTLTAQSHMYEKTIAEGE--NLLLKTQGSEKAALQLQLNTIKTNWDTF 2853
Query: 214 ------------QLCQSALRIPEDVVASLPL---CHAALR-------------------- 238
+ + AL+ E V P C L
Sbjct: 2854 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2913
Query: 239 LQEEASRLQHTAIQQC------NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVAT 292
LQ+E QH + + +++ + E E K L Q ++ ++ K
Sbjct: 2914 LQKEMD--QHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 2971
Query: 293 SNI-------QELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 345
N+ QE+ + R + A++ + + S K LTM L +
Sbjct: 2972 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3031
Query: 346 EGLAE--------------GTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEE 391
LA+ GT D+ ++ H ++ +C L + + +
Sbjct: 3032 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3091
Query: 392 GTNSEISSPPA-----CRSPSPVANTDASVNQDI----AYYQALSAERLQTDAAKIHPST 442
T E+ S A S +PV ++ + A+ + L A D A
Sbjct: 3092 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 3151
Query: 443 SASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTK 502
+ E P L L L + L + ++ + ++R +++ L+ S
Sbjct: 3152 MLATEETSPDLV-GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS-- 3208
Query: 503 MEAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSS------LAEELV 553
I L+ +E E + P E++ Q M ++ ++EI LQ L + L+
Sbjct: 3209 ---ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ-KEEIEPLQGKQQDVNWLGQGLI 3264
Query: 554 SESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYR 613
+ ++ + L+ L + R T+ K + + L+E L L R + AL+
Sbjct: 3265 QSAAKSTSTQ--GLEHDLDDVNARWKTLNKKVAQRAAQLQEAL---LHCGRFQDALE--- 3316
Query: 614 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQ---------LMDCQNMLVEI------- 657
L SW++ T+ + P E ++AQ L+D + VE+
Sbjct: 3317 ----SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3372
Query: 658 -------EQKVVALSELSVHNENL-LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD 709
KV L +LS+ + L KA T++ R+L+G + Q+ H+
Sbjct: 3373 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRN---------RQLEGISVVAQQ-FHE 3422
Query: 710 --KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 767
+ LN T EK + + TQ+ ++E +AQ + + K L Q ++
Sbjct: 3423 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKAL----EDDIINHNKHLHQAVSI 3478
Query: 768 QKSLLRSVASRGEEILIQHSA-------AETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 820
+SL + ++SR ++ ++Q E + + ++L Q L K ED++
Sbjct: 3479 GQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVE 3535
Query: 821 -MKW-ESLH--------QEFSTKQKLLQ-NVLEQEQEQVLYSRPN---RLLSGVPLYKGD 866
M W +H Q++ST+ Q + L QE +L + N LL+G+ L K
Sbjct: 3536 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLK-Q 3594
Query: 867 VPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEE 923
+ + L+ + +++++ S + Q++ L ++L+ TWLD VE
Sbjct: 3595 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3654
Query: 924 RL--FVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPE-------NGDN 974
L + L EE + L K+ K +D + N S A E G
Sbjct: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD-SLNEVSSALLELVPWRAREGLE 3713
Query: 975 RDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 1034
+ V ED R L+ + Q+ ++ + +
Sbjct: 3714 KMVAEDN-----ERYRLVSDTITQKVEEIDAAILR------------------------- 3743
Query: 1035 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 1094
+ F+Q ++ I + E L +E + +LQV++ E+ + +D+ D+L
Sbjct: 3744 -SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3802
Query: 1095 MMIIGSRRSGLNQN--LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 1152
+ + ++ ++K + ++ L++ + + E+ E Q L++
Sbjct: 3803 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYL--------QLERAQSLVN 3854
Query: 1153 KHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYIL 1212
+ E ++ L LTET + IIS +L A A LEY
Sbjct: 3855 QFWETYEELWPW--LTET--QSIIS-----------QLPAPA-------------LEY-- 3884
Query: 1213 ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQ 1272
ET QQE RQL L+ E++ + +N+ P+L +
Sbjct: 3885 ETL----RQQQEEHRQLRE---------LIAEHKPHI-----------DKMNKTGPQLLE 3920
Query: 1273 VLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLI 1332
L G+ I ++ +Q+ E + K L+ + T++ + ++
Sbjct: 3921 -LSPGEGFSIQEKYVAADTLYSQIKE-------DVKKRAVALDEAISQSTQFHDKIDQIL 3972
Query: 1333 HWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR 1392
L+ +RL +Q ++ E+E +++ ++ S +++ L ++ G +++
Sbjct: 3973 ESLERIVERL----RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 4028
Query: 1393 L-----KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 1447
K + ++ +L ++ W ++ T + + KL L + +L + MS I
Sbjct: 4029 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKL--LDVMELAEKFWCDH-MSLI 4085
Query: 1448 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVE 1507
+++ D I + + + + + +I+ Q +D V + + S+ +
Sbjct: 4086 VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIV----INLGSELIA 4141
Query: 1508 S-KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 1566
+ DK + + +N +W L ++I LE +++ +Y++ +Q + W +
Sbjct: 4142 ACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 4201
Query: 1567 KRLKQQHRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSS-IV 1624
+L IG D +V+ +++ + + ++ E+E++ L++ E+ V
Sbjct: 4202 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTV 4261
Query: 1625 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLT 1684
L EL W +L+ + + L+ L + A D++ ++L LS + +
Sbjct: 4262 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4321
Query: 1685 GSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRW 1744
G +A+++++ LQ+D+ + +++ N L++ L N L+ +N RW
Sbjct: 4322 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4381
Query: 1745 NNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN---KDIADD 1801
N+LE+ ++ Q L+ + K + + Q D LL + + A +
Sbjct: 4382 QNVLEKTEQRKQQLDGALR---QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKE 4438
Query: 1802 EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE 1861
++ ++ C T K L + G+Q+ + SA + I D +L + ++E
Sbjct: 4439 QLNVHMEVCAAFEAKEETYKS----LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4494
Query: 1862 QALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELK 1921
L +++T L+ + F SL+ W+ +AE+ L S L T+ +++E K
Sbjct: 4495 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP-SLILDTVLFQIDEHK 4553
Query: 1922 GQMLKFSSMAPDLDRLNELGYRLPL--NDKEIKRMQNL----NRHWSLISSQTTERFSKL 1975
+ +S + L++ G L +++ ++NL W + + ER L
Sbjct: 4554 VFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL 4613
Query: 1976 QSFLLQHQTFLEKCETWMEFLVQTEQKL--AVEISGNYQHLLEQQRAHELFQAEMFSRQQ 2033
+ + F E ME+L ++E+ L +EI+ + + Q H+ FQ + ++
Sbjct: 4614 DDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHS 4673
Query: 2034 ILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRY 2092
+ + G+ L E+ + DD + + L+ L ++W + ++ +R+ ++ + ++
Sbjct: 4674 VYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4733
Query: 2093 REMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAG 2152
+ + L WL V ++ V + L D K F ++ G +V+A
Sbjct: 4734 TDALQALIDWLYRVEP-QLAEDQPVHGDIDLVMNLIDN----HKAFQKELGKRTSSVQAL 4788
Query: 2153 KQL---LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADS 2209
K+ L+ + ++ ++ E+ +W++ ++ +L L+ E+ +
Sbjct: 4789 KRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL 4848
Query: 2210 LEKLRTFKKKLSQS--LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS 2267
LE L ++ L LPD + L + KE + +L + + + DT+ A
Sbjct: 4849 LEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICH 4908
Query: 2268 ADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV 2327
D I+ + + +++ ++EE+ +Q++ L E + L WL E+ +
Sbjct: 4909 PDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTL 4968
Query: 2328 SQNGDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAK-----ASH---- 2372
+ +I + IE++K + + EE+ Q + ++ + +R A SH
Sbjct: 4969 TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVL 5028
Query: 2373 -----------------ESKASEIEYKLGKVN---DRWQHLLDLIAARVKKLKETLVAVQ 2412
++IE K +VN +WQ + L R +KL + L ++
Sbjct: 5029 DKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLE 5088
Query: 2413 QL 2414
+L
Sbjct: 5089 EL 5090
Score = 182 bits (462), Expect = 5e-45
Identities = 617/3357 (18%), Positives = 1313/3357 (39%), Gaps = 415/3357 (12%)
Query: 28 LTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLR 87
L L IR+ + S L+Q + E + ++ +L W+++ +V T W S
Sbjct: 576 LQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT-EWGSDLPSV 634
Query: 88 EQYIL-HQTLLEESKEIDSEL-EAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIK 145
E ++ H+ + +E +S L EA ++Q + T ++++ L + +L +
Sbjct: 635 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT--YAEKLHRLESQYAKLLNTSR 692
Query: 146 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMES 205
+ ++L + + EL L E+ A S ++ K+ + L+ E++
Sbjct: 693 NQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKD--YHAELMRELDQ 750
Query: 206 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ-- 263
+ +++VQ L + E+ A L + +Q + S + +Q C ++ + +
Sbjct: 751 KEENIKSVQEIAEQLLL-ENHPARLTIEAYRAAMQTQWSWI----LQLCQCVEQHIKENT 805
Query: 264 -YEQYEQEMKHLQQLIEGAHREIEDKPVA--TSNIQELQAQISRHEELAQKIKGYQEQIA 320
Y ++ + K + I+ K +S+I +L+ + E +++ Y+ IA
Sbjct: 806 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 865
Query: 321 SLNSKCK-MLTMKAKHATM-LLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 378
+L K K ++ +K +++ L T ++ + + + + + + A H
Sbjct: 866 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI-------EITIYKDDECVLANNSH 918
Query: 379 TLLSPVTEESGEEGTNSEI--SSPPACRSPSPVANTDASVNQDIAYY---------QALS 427
V +G E + + PP + +AN Q++ +S
Sbjct: 919 RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 978
Query: 428 AERLQTDAAKIHPSTSAS----------------QEFYEPGLEPSATAKL--GDLQRSWE 469
L + +I S AS Q +E LE S +++ G E
Sbjct: 979 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1038
Query: 470 TLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPE----PGRSP----- 520
NV + + L ++ ER+++ + +++ I L+L + R+P
Sbjct: 1039 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1098
Query: 521 --ES--QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 576
ES ++ E + L E+ L+D++ + + EE S++ + L+S L V+ +
Sbjct: 1099 LHESVFRITEQEKLKKELERLKDDLGTITNK-CEEFFSQAAASSSVP--TLRSELNVVLQ 1155
Query: 577 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 636
M+ + +S L+ Q E ++ Y + E ++ +++ K ++ +S
Sbjct: 1156 NMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA-VIADKNNIENLIST 1214
Query: 637 PKEPMDMEAQLMDCQNMLVEIEQKVVALS-ELSVHNENLLLEGKAHTKDEAEQLAGKLRR 695
K+ + + L + QK A+S E+ + L+ H K++A+QL + R
Sbjct: 1215 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH-KEKADQL---VER 1270
Query: 696 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSL 755
+ +++ L D ++G + + T P + +W+ Q TT + +++
Sbjct: 1271 WQNVHVQIDNRLRD----LEGIGKSLKY----YRDTYHP-LDDWIQQVETTQRKIQENQP 1321
Query: 756 QQQKELEQELAEQKSLLRSVASRGEEI-LIQHSAAETSGDAGE-KPDVLSQELGMEGEKS 813
+ K L +L +QK L+ + + ++ Q A + S + + ++ ++ ++
Sbjct: 1322 ENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1381
Query: 814 SAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS 873
S + RM+ S+ ++Q ++ L +R L++ + Y K
Sbjct: 1382 SPVKRRRMQ--------SSADLIIQEFMD------LRTRYTALVTLMTQY-------IKF 1420
Query: 874 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLP 933
A SL + EE K++ + ++L VS S L D E+ A P
Sbjct: 1421 AGDSL-----KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK------AGKP 1469
Query: 934 EETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 993
++ + ++EI K KE E + LF ++GD + D
Sbjct: 1470 PFSKQKISSEEISTK--KEQLSEALQTIQLF---LAKHGD----------------KMTD 1508
Query: 994 SVVNQRCHQMKERLQQILN--FQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQ 1051
N+ Q+K LQ+ N F LK L S + +K+ +Q E+++ I
Sbjct: 1509 EERNELEKQVK-TLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGIC 1567
Query: 1052 QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111
+ G E GD EL K Q +EL + L +
Sbjct: 1568 DLLTQTENRLIGHQEAFMIGD-------GTVELKKYQSKQEELQKDMQGSAQALAE---- 1616
Query: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 1171
+++ + L+ EK++ + K + I+Q L++ K + L ++
Sbjct: 1617 ------VVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLNLKAEQSKKE 1664
Query: 1172 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL-SRQLE 1230
K+++ A+++ET + A +K+ + ++E +L+ S++D+D + ++ +
Sbjct: 1665 LDKVVTTAIKEET--------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQ 1716
Query: 1231 VVESS---------IPSVGLVEENEDRLIDRI------TLYQHLKSSLNEYQPKLYQVLD 1275
V+E + ++G +E L++ T ++L + + + +++
Sbjct: 1717 VIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIIS 1776
Query: 1276 DGKRLLISISCSD--LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIH 1333
+ ++I+ + LE Q L K+ K + L+ + + L H
Sbjct: 1777 QHQAVIIATQSAQVLLEKQGQYLSP---EEKEKLQKNMKELKVHYETALAESEKKMKLTH 1833
Query: 1334 WLQSAKDR-------LEFWTQQSVTVPQELEMVRDHLNAFL-------EFSKEVDAQSSL 1379
LQ ++ E W QQS + LE D +N + FS++V +
Sbjct: 1834 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1893
Query: 1380 KSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 1439
+ +GN++L K S+ D D VQ KL D+ S ++
Sbjct: 1894 LRYITISGNRVLEAAK--------SCSKRDGGKVDTSATHREVQRKLDH-ATDRFRSLYS 1944
Query: 1440 ISEVM--SWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQS 1497
V+ + L++ ++ + G +A K+ I ++ K L
Sbjct: 1945 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2004
Query: 1498 VL--QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 1555
L QISSQ V ++ KT AE L S + + + + + G E S+ N
Sbjct: 2005 ALQGQISSQQVAVEKLKKT--AEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN-- 2060
Query: 1556 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 1615
E+ K Q + SVQ+ L + D +++ KE ++ N AL
Sbjct: 2061 ----------ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL--- 2107
Query: 1616 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV-LDQWSSHKVAFDKINSYLMEAR 1674
+D+ S + +++ ++++ M ++K +++ SS + +++ EA
Sbjct: 2108 --QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEAS 2165
Query: 1675 YSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP---VTE 1731
+ + + +E ++ +V+ +NL + LQ F Q L E P VTE
Sbjct: 2166 H---KHKETLAKMEELKTKVELFENLSE-------KLQTFLETKTQALTEVDVPGKDVTE 2215
Query: 1732 TLTNTLKEVNMRW----------NNLLEEIAEQ-LQSSKAL-LQLWQRYKDYSKQCASTV 1779
L+ ++E + ++LL+EI+ L S KAL L+ K+ T+
Sbjct: 2216 -LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTI 2274
Query: 1780 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 1839
+++++ + + + +WI++ K + V+ S F +LG+ L+
Sbjct: 2275 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETT---KKVPIVQPS-FGAEDLGKSLEDTKK 2330
Query: 1840 ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL 1899
++++ ++ Q + SL + T AK++ A+++ +L
Sbjct: 2331 LQEKWSLKTPEI----------QKVNNSGISLCNLISAVTTPAKAIAAVKS----GGAVL 2376
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNR 1959
G+ + +++ + + +K M S DL L L DK + LN
Sbjct: 2377 NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLL--------LKDK----IAELNT 2424
Query: 1960 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQR 2019
S + E + +Q ++T W + T+ + AV+ +EQ +
Sbjct: 2425 KLSKLQKAQEESSAMMQWLQKMNKT----ATKWQQTPAPTDTE-AVKTQ------VEQNK 2473
Query: 2020 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
+ E + ++ Q L + + L E + + LT + ++WQ + + R+
Sbjct: 2474 SFEAELKQNVNKVQELKDKLT--ELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2531
Query: 2080 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 2139
++ +++ + +L++WLVE L +S LG + I T +VQ + F
Sbjct: 2532 QKLEESSNNLTQFQTVEAQLKQWLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2590
Query: 2140 RQQGSYILTVEAGKQLLL--SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 2197
++ Y AG+ +L D ++ +LA + +KW S + +L ++ + +
Sbjct: 2591 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2650
Query: 2198 DWEKCEKGIADSLEKLRTFKKKLSQSL--PDHHEELHAEQMRCKELENAVGSWTDDLTQL 2255
+ + + +KL KLS SL H + ++ + ++++ + +
Sbjct: 2651 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2710
Query: 2256 SLLKDTLSAYISADDISI-LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK 2314
L + LSA + + + L+ ++E + + ++++ + Q + F + ++
Sbjct: 2711 QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSR 2770
Query: 2315 ELCEWLTQMESKVSQNGDILIE-EMIEKLKKDYQE--EIAIAQENKIQLQ-QMGERLAKA 2370
+ WL + + +++ I + +++E L KD+++ + AQ + + GE L
Sbjct: 2771 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2830
Query: 2371 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 2430
+ S+ + ++ +L + W + R KLKE+L + + + +L W+ ++
Sbjct: 2831 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2890
Query: 2431 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD---ACATD 2487
L + + + E + + + + LQ+++++H V + N LL C+ TD
Sbjct: 2891 NLEE--IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2948
Query: 2488 AECDSIQQATRNLDR-RWRNICAMSMERRLK-IEETWRLWQKFLDDYSRFEDWLKSSERT 2545
IQ+ ++ + C +M ++ K +E + ++ L D + S +
Sbjct: 2949 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD-IHDSLGS 3007
Query: 2546 AAFPSSSGVIYTVAKEELKKFEAFQRQV--------------------HECLTQLELINK 2585
A+ S T+ + + K +A + QV + L Q+E I +
Sbjct: 3008 QAY---SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQ 3064
Query: 2586 QYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSIL 2645
++ L+++ D CS + +G + N ++ Q EF+ DS
Sbjct: 3065 EHSTLSQQ--VDEKCSFLETKLQGIGHFQN----------TIREMFSQFAEFDDELDS-- 3110
Query: 2646 VWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 2705
+ + ++ E ++A +K+L+A + + ++A E++ P D
Sbjct: 3111 --MAPVGRDAETLQKQKE-TIKAFLKKLEALMASNDNANKTCKMMLA-----TEETSP-D 3161
Query: 2706 AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 2765
I+ +L+ L + C ++ R + +++ +E +E S L H
Sbjct: 3162 LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF----SILLQKAEEH 3217
Query: 2766 DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR 2825
+ S + + N L++ + + E P + W L + L + ++
Sbjct: 3218 EESQGPVGMETETINQQLNMFKVFQKEEI---EPLQGKQQDVNW-----LGQGLIQSAAK 3269
Query: 2826 ALPSED-EEGQDDKDFYLRGAVGLSGDHSA-LESQIRQLGK---ALDDSRFQIQQTENII 2880
+ ++ E DD + + +A L+ + G+ AL+ + TE ++
Sbjct: 3270 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3329
Query: 2881 RSKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST 2934
++ P E K +LL + S+++ +KR K+ E L
Sbjct: 3330 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL--- 3386
Query: 2935 ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE 2994
Q + + RWE L +A ++ +++ QQF+ L + WL E+ L +
Sbjct: 3387 -KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE--P 3443
Query: 2995 LSTDIQTIELQIKKLKELQ-KAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQMN 3052
+ T +E QI + K L+ ++H K + ++++ S+E +D+ Q +L
Sbjct: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQ 3502
Query: 3053 GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL 3112
+ + LLQ AL + F E L+ L + + +++ D E L
Sbjct: 3503 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD--YSTEGL 3560
Query: 3113 QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKE 3172
+L ++ ++L + V +LL G + L ++K+ I R K + K
Sbjct: 3561 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3620
Query: 3173 VSRHIKELEKLLDVS----SSQQDLSSWSSADELD-TSGSVSPTSGRSTPNRQKTPR 3224
+ K LE+ L ++ S+ ++L +W E++ S G Q P+
Sbjct: 3621 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3677
Score = 96.3 bits (238), Expect = 5e-19
Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)
Query: 1330 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 610 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 662
Query: 1387 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 1446
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 663 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 714
Query: 1447 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 1506
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 715 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 766
Query: 1507 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 1565
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 767 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 824
Query: 1566 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 1623
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 825 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 877
Query: 1624 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 1678
+T + + +I + D +SH+ + I+ EA
Sbjct: 878 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 937
Query: 1679 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 1732
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 938 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 997
Query: 1733 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 1777
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 998 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1057
Query: 1778 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 1817
Q++ EDR ++ +D + V I + L K L
Sbjct: 1058 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1116
Query: 1818 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 1877
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 1117 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1173
Query: 1878 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 1931
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 1174 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1233
Query: 1932 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 1980
+L + + + KE ++ L W + Q R L+ L
Sbjct: 1234 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1293
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 1294 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1349
Query: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1350 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1394
Query: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
+ E L V + Q + D ++ E+
Sbjct: 1395 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1430
Query: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 2216
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1431 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1484
Query: 2217 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 2274
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1485 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1532
Query: 2275 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 2330
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1533 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1584
Query: 2331 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 2376
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1585 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1644
Query: 2377 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 2429
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1645 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1704
Query: 2430 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 2454
SE A K ++ S EE Q LN+Q
Sbjct: 1705 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1764
Query: 2455 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 2509
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1765 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1823
Query: 2510 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 2568
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 1824 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1882
Query: 2569 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 2616
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 1883 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1942
Query: 2617 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 2670
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 1943 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2000
Query: 2671 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 2728
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 2001 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2060
Query: 2729 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 2784
++KL ++ L R L ++D L W SL P S+ L
Sbjct: 2061 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2110
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 2843
+++ + E+ +S+++ ++ ++ M PS Q KD R
Sbjct: 2111 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2160
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 2903
+ S H +++ +L ++ ++ + + +KT E+D K +L
Sbjct: 2161 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2219
Query: 2904 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 2962
S LEHK E SL ++ H + A V+++ L + E +K+
Sbjct: 2220 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2277
Query: 2963 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 2999
++ F + S+ +W+ +T ++ LE ++L+ +
Sbjct: 2278 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2337
Query: 3000 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 3044
+T E+Q L L AV I ++ + + E T +++E +
Sbjct: 2338 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
+ ++ ++ ++ + LL++ L L + Q E S ++ L+ +++ +
Sbjct: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457
Query: 3105 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 3164
+ D E ++ +Q + EL ++ +V L+D +LL E D EA
Sbjct: 2458 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2507
Query: 3165 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 3209
R K +L E+ +EL +L L+ SS+ + L W EL S +
Sbjct: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2566
Query: 3210 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 3269
P S PN T R + + + P LS PG S RG + L
Sbjct: 2567 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2624
Query: 3270 RA 3271
A
Sbjct: 2625 AA 2626
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 264 bits (675), Expect = 1e-69
Identities = 605/3391 (17%), Positives = 1312/3391 (38%), Gaps = 380/3391 (11%)
Query: 32 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 91
H+Q I Q + S + E +E+ +L+ +V GT N Q ++
Sbjct: 1388 HKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNLLETDVDGQV---GTTQENLNQQYQKVKA 1443
Query: 92 LHQTLLEESKEI---DSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRL 148
H+ ++ + + + + + EK S EK+ + + EL E + ++
Sbjct: 1444 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1503
Query: 149 QNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGR-------LSLKEQLSHRQHLLS 201
+ ++++KF+A+ + + L+Q++ L + E G LK Q S + ++S
Sbjct: 1504 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1563
Query: 202 EMESLKPKV----QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIM 257
L+ + ++ +S + V + R + A+ + +CN++
Sbjct: 1564 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1623
Query: 258 ----QAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRH--EELAQK 311
+ V +Y+ YE L + +Q +A S+H E +A
Sbjct: 1624 GNNLKDLVDKYQHYEDASCGL-----------------LAGLQACEATASKHLSEPIAVD 1666
Query: 312 IKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVM 371
K Q Q+ + ++ + ++ + V +++ AE D G LLP + +
Sbjct: 1667 PKNLQRQLEETKA------LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD 1720
Query: 372 MTAGRCHTLLSPVTEE------------SGEEGT--------NSEISSPPACRSPSPVAN 411
GR L V E S ++G N E S + P
Sbjct: 1721 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTA 1780
Query: 412 TDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETL 471
++++I Q ++ + +A ++ E +P S AK+ DL +
Sbjct: 1781 LQDIISKNIMLEQDIAGRQSSINA--MNEKVKKFMETTDPSTASSLQAKMKDLSARFSEA 1838
Query: 472 KNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALM 531
+ E + E + + +++ + + T +E L+E PG+ Q
Sbjct: 1839 SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQEST 1898
Query: 532 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMS-TIRMKASGKR- 589
E L + + E+ SL +E+ S +D A L + L+ + M TI+ K
Sbjct: 1899 SEFLEHKKHL-EVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 1957
Query: 590 --------QLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPM 641
Q+L + L ++E ++ + + A++L L TK + E
Sbjct: 1958 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2017
Query: 642 DMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK-LRRLKGSL 700
+ + N++ + A++ +V + +L G+ + E A K L +K +
Sbjct: 2018 KVNNSGISLCNLISAVTTPAKAIA--AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDM 2075
Query: 701 LELQRALHDKQLNMQGTAQEKEE--SDVDLTATQSPGVQEWLAQARTTWTQQRQS----- 753
++ D L ++ E S + +S + +WL + T T+ +Q+
Sbjct: 2076 TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2135
Query: 754 ------SLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP-------- 799
++Q K E EL + + ++ + + E+L E + D E P
Sbjct: 2136 TEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL------EENPDTPEAPRWKQMLTE 2189
Query: 800 -DVLSQELGM-------EGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVL---------- 841
D QEL + E+SS E+ +++ +++L+ +VL
Sbjct: 2190 IDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNML 2249
Query: 842 --EQEQEQVL----------YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV 889
+++Q Q+L Y + G+ G+ P+ + V L + Q ++ +
Sbjct: 2250 NTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSL-RGIVKEQLAAVTQKWDSL 2308
Query: 890 SSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEIL 946
+ Q Q+I + + + S L D++ +L + A+ T NQ++
Sbjct: 2309 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV---STHPDAMNQQLE 2365
Query: 947 AKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL--SLLDSV--VNQRCHQ 1002
+ + +K + +QA E+ V E+ L L R +L S V Q+
Sbjct: 2366 TAQKMKQEIQQEKKQIKVAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAEN 2424
Query: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062
+ LQ + + + ++ +K P++ +++ ++ K+F
Sbjct: 2425 HVQHLQSACASSHQFQQMSRDF--QAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2482
Query: 1063 GIIELKRRGDKLQVEQPSMQ-------------ELSKLQDMYDELMMIIGSRRSGLNQNL 1109
+ +K E ++ +L+ ++ +D + R + L ++L
Sbjct: 2483 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2542
Query: 1110 TLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE--IQQLLDKHKEYFQGLESHMIL 1167
+Y+ ++ L ++ Q + + + ++ E I +L KE Q +L
Sbjct: 2543 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELL 2602
Query: 1168 TETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL 1225
T + + KE T + L+ + V ++ H + LE + + + E +E
Sbjct: 2603 NNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 2662
Query: 1226 SRQLEVVESSIP---SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
RQL+ + + S+G + L T+ Q + SL + ++ + L++
Sbjct: 2663 KRQLQCAKEQLDIHDSLGSQAYSNKYL----TMLQTQQKSLQALKHQVDLAKRLAQDLVV 2718
Query: 1283 SIS----CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSA 1338
S SD+ Q+ + + + + ++ ++ LET L+ +Q+ ++
Sbjct: 2719 EASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 2778
Query: 1339 KDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-- 1396
D L+ V ++ E ++ F K+++A + + T +L ++
Sbjct: 2779 DDELD----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 2834
Query: 1397 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQK 1456
D ++ +L + Q LL A +E++ + +L + S++ + L++ +
Sbjct: 2835 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT-IKRLEEFY--SKLKEFSILLQKAEEH 2891
Query: 1457 DEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESKRSD 1512
+E + + I++ L +K F+ + + KQ V+++ Q ++Q +++ ++ +
Sbjct: 2892 EESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLE 2951
Query: 1513 KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKRLKQ 1571
L +N W+ L V ++ L+ L +++ ++ L +W +T+E Q
Sbjct: 2952 -----HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ 3006
Query: 1572 QHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLREL 1631
+ + V+ +++ + L+ L+ ++ VE I++ G + + ++ L L
Sbjct: 3007 KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLL 3066
Query: 1632 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 1691
W L + L+ + + +N +L L + ++
Sbjct: 3067 DSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLE 3126
Query: 1692 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751
Q+ + L+DD+ + L + SI Q LK + + + + + W EI
Sbjct: 3127 EQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQVW---YIEI 3182
Query: 1752 AEQLQSSKALLQL--------------WQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 1797
E+ S LLQ + + S + Q+ T L K +
Sbjct: 3183 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3242
Query: 1798 IADDEVATWIQDCND-LLKGLGTVK----DSLFFLHELGEQLKQQ------VDASAASAI 1846
+ +++ Q+ + LL GL +K D + + + E +K + + A +
Sbjct: 3243 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3302
Query: 1847 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 1906
+ L L++ L + + LC ++ +L YET ++L+G++ S
Sbjct: 3303 EQ-ALQLARRLHSTHEELCTWLDKVEVELLSYET----------------QVLKGEEASQ 3345
Query: 1907 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL----PLNDKE--IKRMQNLNRH 1960
+ Q R +ELK + ++ LD LNE+ L P +E K + N
Sbjct: 3346 A------QMRPKELKKEAKNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAEDNER 3396
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQ 2018
+ L+S T++ ++ + +L+ Q F + + + ++ +TE+KL +I Q
Sbjct: 3397 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3456
Query: 2019 RAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
+ + F E+ + I+ ++ G +++ +++ KL + + + + +R
Sbjct: 3457 QVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3516
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV- 2137
++ ++ E E+L WL E + + +P P + TL + + ++
Sbjct: 3517 YLQLERAQSLVNQFWETYEELWPWLTETQSI----ISQLPAPALEYETLRQQQEEHRQLR 3572
Query: 2138 -FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM---RLEEQKKKLA 2193
+ + +I + LL G E IQEK+ +A +++E KK A
Sbjct: 3573 ELIAEHKPHIDKMNKTGPQLLELSPG-------EGFSIQEKYVAADTLYSQIKEDVKKRA 3625
Query: 2194 FLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLT 2253
L + D ++++ +++ + L + AE + KE + + + D+
Sbjct: 3626 VALDEAISQSTQFHDKIDQILESLERIVERLRQP-PSISAEVEKIKEQISENKNVSVDME 3684
Query: 2254 QLSLLKDTLS-------AYISADDISI----LNERVELLQRQWEELCHQLSLRRQQIGER 2302
+L L +TL A D I + ++++ + WE + + R ++ +
Sbjct: 3685 KLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 3744
Query: 2303 LNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKD----YQEEIAIAQENKI 2358
+ F + L + + + D I+ + K +++ +EEI QE
Sbjct: 3745 MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELD 3804
Query: 2359 QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ +G L A E ++ + ++N W L R+ KL+E + A Q +
Sbjct: 3805 IVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 3864
Query: 2419 SSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
++ W+ +LA PI D E +++++ E ++ + + + + + + E+
Sbjct: 3865 QAVFDWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL 3921
Query: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
LL +++ ++Q L W ++ + R+ K+E +F
Sbjct: 3922 LLKKV---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 3978
Query: 2537 DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT 2596
WL +E + G + EL K Q V + +E +NK L +
Sbjct: 3979 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4038
Query: 2597 DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 2656
+ A +L+ + NQRW N+ ++ ++L + Q + F + + WLT+ + L
Sbjct: 4039 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4098
Query: 2657 NIEHFSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIEEEL 2713
+ AK +QL + + K E ++ +G+Q++ + I++++
Sbjct: 4099 ASKPLGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDI 4157
Query: 2714 DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL- 2772
+ L+ + V E L++R+ +LE++ L+ + +H+ D +
Sbjct: 4158 NNLKEKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQDFIN 4197
Query: 2773 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 2832
Q L+++ L +D++ + D + ++ S + + D+
Sbjct: 4198 WLTQAEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQIIEL-DK 4245
Query: 2833 EGQDDKDFYLRGAVGLSGD-----HSALESQIRQL---GKALDDSRFQIQQ--------T 2876
G K F + V L + S E +++L G++LDD+R + +Q
Sbjct: 4246 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4305
Query: 2877 ENIIRSKTPTGPELDTS------------YKGYMKLLGECSSSIDSVKRLEHKLKEEEES 2924
E + S+ EL+ + +K + K LG S D+ R LKE+
Sbjct: 4306 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4365
Query: 2925 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
+ L + + + D+W+ + +++ ++ ++++ L QF L ++ WL E
Sbjct: 4366 ADDNLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4422
Query: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 3044
+L + Q + DI + I K QK + R + + ++ + E + +S +
Sbjct: 4423 PQLAEDQPVH--GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4480
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVP 3102
+ ++ +++ RW+ VC+L + L+ AL Q + FH + H LL L ++ R + ++P
Sbjct: 4481 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4540
Query: 3103 IDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
D + L D HK+ M+ +L E + + M +L K + +I
Sbjct: 4541 DDEDA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4596
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 3193
R + +L +H + L L ++Q+L
Sbjct: 4597 RARFEEVLAWAKQHQQRLASALAGLIAKQEL 4627
Score = 253 bits (647), Expect = 2e-66
Identities = 639/3471 (18%), Positives = 1341/3471 (38%), Gaps = 495/3471 (14%)
Query: 23 KKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNS 82
+K +L E Q Q +NRL L L+ Y + + WI++ + I N
Sbjct: 936 EKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET-TQRKIQENQ 994
Query: 83 -------ASQLREQYIL------HQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ 129
A+QL +Q +L Q+ ++E ++ + A + + T Y SQQ
Sbjct: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
Query: 130 VAELGR------------ETEELR----QMIKIRLQNLQDAAKDMKKFEAE--------- 164
+ + R E +LR ++ + Q ++ A +K+ E E
Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
Query: 165 -----LKKLQAALEQAQATLTSPE-VGRLSLKEQLSHRQHLLSEMESLKPKVQAVQL--- 215
K+LQ + TL E G+ +Q + + ++ E L +Q +QL
Sbjct: 1115 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1174
Query: 216 -----------------------------CQSALRIPE-----DVVASLPLCHAALRLQE 241
+S ++ E DV + A R QE
Sbjct: 1175 KHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI--VAERQQE 1232
Query: 242 EASRLQH------------TAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKP 289
+LQ Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + +
Sbjct: 1233 YKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVV 1292
Query: 290 VATSNIQELQAQISRHEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGL 348
T N + E+L+Q+ K EQ + KC+ L +KA+ + L +
Sbjct: 1293 KNTENFLK-----ENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1347
Query: 349 AEGTEDLDGELLPTPSAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGT-NSE 396
E TE + S S V + R T V E++G +EG S
Sbjct: 1348 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSA 1407
Query: 397 ISSPPACRS-------PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQE 447
I V T ++NQ YQ + A E++ + + +T ++Q
Sbjct: 1408 IGEEDEVNGNLLETDVDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQV 1464
Query: 448 FYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAI 506
E + + + LQ++ + LK YE AL +K S+ ++E
Sbjct: 1465 LLEKQGQYLSPEEKEKLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKF 1516
Query: 507 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS------------ 554
+ +E + E ++ +A D+I L ++ Q S +E+++S
Sbjct: 1517 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISG 1575
Query: 555 -------ESCEADPAEQLALQSTLTVLAERM--STIRMKA-SGKRQLLEEKLNDQLEEQR 604
+SC ++ +T + ++ +T R ++ K +L L D +++
Sbjct: 1576 NRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK-- 1633
Query: 605 QEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVV 662
Q Y + L + L + +AT LS P +P +++ QL + + + +I + V
Sbjct: 1634 ----YQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQV 1689
Query: 663 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE 722
A+ +L E +LL+ + + L + G +L ++++++ +Q
Sbjct: 1690 AVEKLKKTAE-VLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------- 1741
Query: 723 ESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSV 775
+T T+S VQ+ L + W +SSL++Q + L+ +++ L + +
Sbjct: 1742 -----ITLTRSLSVQDGLDE-MLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 1795
Query: 776 ASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESL--HQEFSTK 833
A R I + + + + S + M+ + + E+L +E TK
Sbjct: 1796 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 1855
Query: 834 QKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQS 893
+L +N+ E+ Q + L+ V DVP +D + L+Q +E +S+
Sbjct: 1856 VELFENL--SEKLQTFLETKTQALTEV-----DVPGKD-------VTELSQYMQESTSEF 1901
Query: 894 GGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEM 953
K+ L L + +++ LP + L L+K KEM
Sbjct: 1902 LEHKKHLEVLHSLLKE-----------------ISSHGLPSDKALVLEKTNNLSKKFKEM 1944
Query: 954 SEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQIL 1011
+ + + K + E D V+ +L + + +V + + L+
Sbjct: 1945 EDTIKEKKEAVTSC-QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTK 2003
Query: 1012 NFQN--DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKR 1069
Q LK +N I L L + P A+ I A++ +G L
Sbjct: 2004 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNG 2052
Query: 1070 RGDKLQVEQ--------PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQ 1120
G E+ ++++ + Y++L +++ + + LN L+ L+ E +
Sbjct: 2053 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSA 2112
Query: 1121 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHM--------ILTETLF 1172
+ L + + Q + E ++ ++++K + L+ ++ LTE L
Sbjct: 2113 MMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLE 2172
Query: 1173 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV 1232
+ + Q TE+ ++ + + R +LE + + +L + L
Sbjct: 2173 ENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEK 2232
Query: 1233 ESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---- 1288
E + +G + + + L + Q L +P+ Q+ G+ +L S D
Sbjct: 2233 ELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLR 2291
Query: 1289 --LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
++ QL + + W S T ++S ++ + T+YQS L+ L L+
Sbjct: 2292 GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQS----LLRSLSDKLSDLDNKL 2347
Query: 1347 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELS 1406
S+ V + + L + +E+ + + L L K + L++ELS
Sbjct: 2348 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE--YLKAELS 2405
Query: 1407 RIDSQWTDLLTNIPAVQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDED 1459
R Q +L + V++K Q S H ++ +W+ +K+E
Sbjct: 2406 R---QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD-----TKKEEQ 2457
Query: 1460 NIKNSIGYK--AIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 1517
N + I K + ++ +K F + + +++ + + ++++ S+K
Sbjct: 2458 NKSHPISAKLDVLESLIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQ 2514
Query: 1518 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 1577
QL + +W V E+ L+ LE +Y+ V+ L W + + L++ D
Sbjct: 2515 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2574
Query: 1578 QASVQNALKDCQDLE------------------DLIKAKEKEVEKIEQNGLALIQNKKED 1619
A +N++ + L+ L+ E + E + +LIQ K +
Sbjct: 2575 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDM 2633
Query: 1620 VSSIVMS---TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYS 1676
V+ + S L + Q + + + K L+ +Q H D + S +Y
Sbjct: 2634 VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY- 2688
Query: 1677 LSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLL 1722
L+ + SL+A++ QVD + L DL + E Q+ +++ Q+
Sbjct: 2689 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 2748
Query: 1723 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 1782
++C L L+ + N + E ++ + L + +D A T+Q+Q
Sbjct: 2749 EKC-----SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQ 2798
Query: 1783 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
++ LK ++D + C +L T D +
Sbjct: 2799 KETIKAFLKKLEALMASNDNAN---KTCKMMLATEETSPDLV------------------ 2837
Query: 1843 ASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
I+ D +LS+ L ++ ++ + E F L+ + +AEE + Q
Sbjct: 2838 --GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQ 2895
Query: 1903 DPSHSSDLSTIQERMEELK-GQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL---- 1957
P + TI +++ K Q + + +N LG L + + Q L
Sbjct: 2896 GPV-GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL 2954
Query: 1958 ---NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQ 2012
N W ++ + +R ++LQ LL F + E+ + ++V TE+ +A + S ++
Sbjct: 2955 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3014
Query: 2013 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 2072
+ Q + +L Q + R+ + I +G+++ + D+ + +L+LL ++W+ ++
Sbjct: 3015 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3074
Query: 2073 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 2132
+A+ R ++ Q++ E E L +WL + + PI Q ++ Q
Sbjct: 3075 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIE---KRLVNCEPIGTQASKLEEQIAQ 3131
Query: 2133 FK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASM 2183
K E + V G+ L + + + +Q++L EIQEK S S
Sbjct: 3132 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3191
Query: 2184 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEE-LHAEQMRCKELE 2242
L++ +D E + + L ++ KL S+ D+ E L +Q + L+
Sbjct: 3192 LLQQALCNAKIFGED----EVELMNWLNEVHDKLSKL--SVQDYSTEGLWKQQSELRVLQ 3245
Query: 2243 NAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGER 2302
+ ++ Q L L + D++ I+ +++E ++ +++++ + + + +
Sbjct: 3246 EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQA 3305
Query: 2303 LNEWAVFSEKNKELCEWLTQMESK-VSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQ 2361
L ++ELC WL ++E + +S +L E + + +E A+ NK L
Sbjct: 3306 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD 3365
Query: 2362 QMGE---RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ E L + +E + + N+R++ + D I +V+++ ++ QQ D+
Sbjct: 3366 SLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAA 3425
Query: 2419 SSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL 2478
+ +W+ E +L + ++ +L Q+ +I +H + ++ ++
Sbjct: 3426 DAELSWITETEKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM 3484
Query: 2479 HDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 2538
C ++ E S+++ + + + IC ++ ER L++E L +F + Y W
Sbjct: 3485 TAC----SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3540
Query: 2539 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 2598
L ++ + + + Y +++ ++ + + E ++ +NK +L E
Sbjct: 3541 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGE 3599
Query: 2599 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 2658
S+++ + + +++ V L I Q +F D IL L + +L
Sbjct: 3600 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3659
Query: 2659 EHFSECDVQAKIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIE 2710
S +V+ KIK+ + + +S++ K+ E + +GE++I +S + + A ++
Sbjct: 3660 PSIS-AEVE-KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 3717
Query: 2711 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 2770
++LD++ + + VE +RE +L D L++ W D +
Sbjct: 3718 DKLDQMVFIWENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS- 3757
Query: 2771 SLLSPQPSSNLSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAM 2823
+++ + + + L P ++ ++ +T +D + E D +L +L +A
Sbjct: 3758 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC 3817
Query: 2824 SRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIR-QLGKALDDSRFQIQQTENI--- 2879
G+ DK + L+ +L + ++ K + + +Q + +
Sbjct: 3818 ----------GEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 3867
Query: 2880 ----------IRSKTPTGPELDT---SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 2926
+ S +P G +L+T + + E ++RL H+ + + +
Sbjct: 3868 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 3927
Query: 2927 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 2986
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE
Sbjct: 3928 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 3987
Query: 2987 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQ 3045
L ++ + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ
Sbjct: 3988 LS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ 4045
Query: 3046 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 3105
++L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 4046 NKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGG 4105
Query: 3106 ---------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 3150
N+ E+ ++ +K LMQ ++L + S + ++ +
Sbjct: 4106 LPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDIN 4158
Query: 3151 DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 3201
+ E E V N K L+E L ++ +S QD +W + E
Sbjct: 4159 NLKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4203
Score = 244 bits (624), Expect = 8e-64
Identities = 429/2257 (19%), Positives = 899/2257 (39%), Gaps = 262/2257 (11%)
Query: 37 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK----------VLAHGTIAWNSASQL 86
+Q + R +KL ++ +Y E +E + WI+K + A G + L
Sbjct: 2529 KQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSL 2588
Query: 87 REQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKI 146
+++ H ++E + L ++ E + T++ + ++ TE+L K
Sbjct: 2589 QKEMDQHFGMVELLNNTANSLLSVCE----IDKEVVTDENKSLIQKVDMVTEQLHSK-KF 2643
Query: 147 RLQNLQDAAKDMKKFEAELKK-LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMES 205
L+N+ K+ ++ E K+ LQ A EQ + + + L+ Q +++
Sbjct: 2644 CLENMTQKFKEFQEVSKESKRQLQCAKEQLD--IHDSLGSQAYSNKYLTMLQTQQKSLQA 2701
Query: 206 LKPKVQ-AVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 264
LK +V A +L Q + D + + + +E S L ++C+ ++ +
Sbjct: 2702 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 2761
Query: 265 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 324
++ ++ + E++ + + LQ Q + +K++ + N
Sbjct: 2762 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 2821
Query: 325 KCKMLTMKAKHATMLLTV-TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSP 383
CKM+ + + L+ + ++E L++ +LL A V T R S
Sbjct: 2822 TCKMMLATEETSPDLVGIKRDLEALSKQC----NKLLDRAQAREEQVEGTIKRLEEFYSK 2877
Query: 384 VTE-----ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 438
+ E + EE S+ PV ++NQ + ++ E ++ K
Sbjct: 2878 LKEFSILLQKAEEHEESQ----------GPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 2927
Query: 439 HPSTSASQEFYEPGLEPSATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
Q + + ++T L D+ W+TL ++++ L EAL ++QD
Sbjct: 2928 QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQD 2987
Query: 495 SLQS-ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELV 553
+L+S +S ++ EL ++ P P ++ +A + E +LQ +++ +S++ E++
Sbjct: 2988 ALESLLSWMVDTEELVANQKP-----PSAEFKVVKAQIQEQKLLQRLLDDRKSTV--EVI 3040
Query: 554 SESCE-----ADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE-------------EK 595
E A+PA+++ + L++L R + KA + + LE E
Sbjct: 3041 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3100
Query: 596 LNDQLE--EQR---------QEQALQRYRCEADELDSWLLSTKATLDTALS--------P 636
LN+ L E+R Q L+ + L+ +++ L A+S
Sbjct: 3101 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLS 3160
Query: 637 PKEPMDMEAQLMD-CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE------QL 689
+E DM +D Q +EI++K + SEL + L K +DE E ++
Sbjct: 3161 SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL---QQALCNAKIFGEDEVELMNWLNEV 3217
Query: 690 AGKLRRL-------------KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGV 736
KL +L + L LQ + ++ N+ E T + +
Sbjct: 3218 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3277
Query: 737 QEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAG 796
Q+ L + + + S K LEQ L L R + S EE+ E
Sbjct: 3278 QDKLEAIKARYKDITKLSTDVAKTLEQAL----QLARRLHSTHEELCTWLDKVEV----- 3328
Query: 797 EKPDVLSQELG-MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 855
++LS E ++GE++S Q +M+ + L +E + LL + L + +L P R
Sbjct: 3329 ---ELLSYETQVLKGEEAS---QAQMRPKELKKEAKNNKALLDS-LNEVSSALLELVPWR 3381
Query: 856 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 915
G+ + +D + D + Q EE+ + +I Q+ A
Sbjct: 3382 AREGLE----KMVAEDNERYRLVSDTITQKVEEIDA--------AILRSQQFDQAADAEL 3429
Query: 916 TWLDDVEERLFVATALLPEETETC-------LFNQEILAKDIKEMSEEMDKNKNLFSQAF 968
+W+ + E++L + E+ +T F EIL K++ +++ K+ + A
Sbjct: 3430 SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH--KDIIDDLVKSGHKIMTAC 3487
Query: 969 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN-FQNDLKVLFTSLADN 1027
E + + ++ L +L + + ++R Q+ ER Q ++N F + L+ L +
Sbjct: 3488 SE--EEKQSMKKKLDKVLKNYDTICQINSERYLQL-ERAQSLVNQFWETYEELWPWLTET 3544
Query: 1028 KYIILQKLANVFE-QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP----SMQ 1082
+ II Q A E + + +Q E +Q + + E I ++ + G +L P S+Q
Sbjct: 3545 QSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQ 3604
Query: 1083 ELSKLQD-MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 1141
E D +Y ++ + R L++ ++ +Q+ + + + LE E++ I
Sbjct: 3605 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSIS 3663
Query: 1142 SSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRA 1201
+ E+I++ + ++K +E L ETL Q E++A++ K
Sbjct: 3664 AEVEKIKEQISENKNVSVDMEKLQPLYETL------------KQRGEEMIARSGGTDKDI 3711
Query: 1202 HKRGVE--LEYILETWSHL----DEDQQELSRQLEVVE-------SSIPSV----GLVEE 1244
+ V+ L+ ++ W ++ +E + +L +E+ E S I ++ + +
Sbjct: 3712 SAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD 3771
Query: 1245 NEDRLIDRITLYQH------LKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQ 1295
ED ID + Q ++ ++ Q +L V++ G L+ + D ++ +++
Sbjct: 3772 LEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDE 3831
Query: 1296 LGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQE 1355
L W S + +LE ++ +YQ + W+ A +L + + +
Sbjct: 3832 LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----PIGTD 3887
Query: 1356 LEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV----DTATLRSELSRIDSQ 1411
LE V+ + +F E Q ++ L+ +LL LKKV D T++ L +
Sbjct: 3888 LETVKQQIEELKQFKSEA-YQQQIEMERLNHQAELL-LKKVTEESDKHTVQDPLMELKLI 3945
Query: 1412 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--YKA 1469
W L I Q KL + +HA+ E+++W++ E ++ + + +G KA
Sbjct: 3946 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-----QKPVGGDPKA 4000
Query: 1470 IHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK-TDFAEQLGAMNKSWQ 1528
I L K+ + D+ Q TV+ VN++ + +ES ++ ++ +L +N+ WQ
Sbjct: 4001 IEIELAKHHVLQNDVLAHQSTVEAVNKA----GNDLIESSAGEEASNLQNKLEVLNQRWQ 4056
Query: 1529 ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNALKD 1587
+ ++ Q L+G L + ++ L+ W E+ L +G + + L
Sbjct: 4057 NVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4116
Query: 1588 CQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKI 1647
++ +AKE+ + + Q G ++ + + + + L + W +++ + + K
Sbjct: 4117 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4176
Query: 1648 LLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 1707
L+ L+ + ++L +A +L+ + L+ V Q+D + +++
Sbjct: 4177 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4236
Query: 1708 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS-------SKA 1760
+ + L + N L V RW +++ + E+ +S +K
Sbjct: 4237 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4296
Query: 1761 LLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTV 1820
+ W + ++ ++ ++ + + N+ D++ T + + K LG
Sbjct: 4297 FHEAWSKLMEWLEESEKSLDSELEIAND-----------PDKIKTQLAQHKEFQKSLGAK 4345
Query: 1821 KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE---QALC----KQQTSLQA 1873
+ G LK++ +++ D L L L L +C ++Q L+
Sbjct: 4346 HSVYDTTNRTGRSLKEK------TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4399
Query: 1874 GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 1933
+L F +L+AL W+ E L P H D+ + ++ K +
Sbjct: 4400 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSS 4458
Query: 1934 LDRLNELGYRLPLNDKEIK-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 1988
+ L L ++ +MQ L+ W + + + + ++L++ L Q + F
Sbjct: 4459 VQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV 4518
Query: 1989 CETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL 2046
+E+L + EQ L + + L H+ F ++ ++ L+ G +L
Sbjct: 4519 VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4578
Query: 2047 EQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV-E 2105
D +T++ +++ V+ A+Q + + S + +E+ E L WL
Sbjct: 4579 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 4638
Query: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQ-FKEKVFLRQ 2141
+ L +P +++ + L E Q F E++ +Q
Sbjct: 4639 ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 4675
Score = 230 bits (587), Expect = 2e-59
Identities = 557/3213 (17%), Positives = 1245/3213 (38%), Gaps = 497/3213 (15%)
Query: 264 YEQYEQEMKHLQQLIEGAH----REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQI 319
Y Y E+++++ +E R+I P+ ++ E +I+ E+L ++++ ++ +
Sbjct: 739 YNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDLHESVFRITEQEKLKKELERLKDDL 797
Query: 320 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 379
++ +KC+ +A ++ + PT + +VV+ + ++
Sbjct: 798 GTITNKCEEFFSQAAASSSV---------------------PTLRSELNVVLQNMNQVYS 836
Query: 380 LLSP----------VTEESGEEGTNSEISSPPACRSPSPVANTDASVN--QDIAYYQALS 427
+ S V + + ++ C + +A+ + N + +++
Sbjct: 837 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV 896
Query: 428 AERLQTDAA---KIHPSTSASQEFYEPGLEPSAT-----AKLGDLQRSWETLKNVISEKQ 479
E+ Q A ++ + + S E ++ E K L W+ + I +
Sbjct: 897 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956
Query: 480 RTLYEALERQQKYQDSLQSISTKMEAIEL---KLSES-PEPGRSPESQMAEHQALMDEIL 535
R L + + Y+D+ + ++ +E K+ E+ PE ++ +Q+ + + L+ EI
Sbjct: 957 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1016
Query: 536 MLQDEINELQS---------------SLAEELVSESCEADPAEQLALQSTLTVLAERMST 580
M Q +++E Q ++ + +S + P ++ +QS+ ++ +
Sbjct: 1017 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1076
Query: 581 IRMKASGKRQLLEEKLN---DQLEE-QRQEQALQRYRCE----ADELDSWLLSTKATLDT 632
+R + + L+ + + D L+ + +E++L+ + E A EL W+ + TL
Sbjct: 1077 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1136
Query: 633 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 692
A K P Q + + + + EQ AL + + L G T +E +L +
Sbjct: 1137 AEKAGKPP--FSKQKISSEEISTKKEQLSEALQTIQLF---LAKHGDKMTDEERNELEKQ 1191
Query: 693 LRRLKGS----LLELQRALHDKQLNMQGTAQEKEESDVD-------------LTATQSPG 735
++ L+ S E + L + Q + +EK ++ LT T++
Sbjct: 1192 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1251
Query: 736 VQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 795
+ A T + + +Q+EL++++ L V E L ++
Sbjct: 1252 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN--------- 1302
Query: 796 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQ--KLLQNVLEQEQEQVLYSRP 853
GEK LSQE E+ E +++ + +L E S K+ K++ +++E E+V +
Sbjct: 1303 GEK---LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1359
Query: 854 NRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSA 913
+ K+ + +LLD L+ + S+ G K + + +
Sbjct: 1360 LE--------------ESKTKIENLLDWLSNV--DKDSERAGTKHKQV---------IEQ 1394
Query: 914 TSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD 973
T + + + + + EE E N +L D+ + +NL Q
Sbjct: 1395 NGTHFQEGDGK-----SAIGEEDEV---NGNLLETDVD--GQVGTTQENLNQQYQKVKAQ 1444
Query: 974 NRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLF-TSLADNKYIIL 1032
+ +I ++ S + Q + E +++ +LKV + T+LA+++
Sbjct: 1445 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESE---- 1500
Query: 1033 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 1092
++++ ++ L++FDA E + LQ + ++ L D +
Sbjct: 1501 ------------KKMKLTHSLQEELEKFDADYTEFEH---WLQQSEQELENLEAGADDIN 1545
Query: 1093 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQ--EKMAGDQKIIVSSKEEIQQL 1150
LM + ++S ++ K +LE + K G + ++ E+Q+
Sbjct: 1546 GLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRK 1605
Query: 1151 LDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEY 1210
LD + F+ L S + + ++ Q L+A A A K
Sbjct: 1606 LDHATDRFRSLYSKCNVLGNNLKDLVD-KYQHYEDASCGLLAGLQACEATASK------- 1657
Query: 1211 ILETWSHLDE----DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 1266
HL E D + L RQLE ++ + + ++L + + SL
Sbjct: 1658 ------HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPA 1711
Query: 1267 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 1326
+ + + LDD I DL +N+ E +L+ L Q
Sbjct: 1712 KNDIQKTLDD-----IVGRYEDLSKSVNERNE--------------KLQITLTRSLSVQD 1752
Query: 1327 ESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
+++ W+ + + L ++ VP ++D ++ + +++ + S ++
Sbjct: 1753 GLDEMLDWMGNVESSL----KEQGQVPLNSTALQDIISKNIMLEQDIAG----RQSSINA 1804
Query: 1387 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 1446
N+ ++KK T S S + ++ DL K H+ + K+ E+ +
Sbjct: 1805 MNE--KVKKFMETTDPSTASSLQAKMKDLSARFSEASHK-HKETLAKM------EELKTK 1855
Query: 1447 ISLMENVIQKDEDNIKN--------SIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ L EN+ +K + ++ + K + E Q + + + ++ ++ +
Sbjct: 1856 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 1915
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 1558
+ISS + SDK E+ ++K ++ ++ + EK + + E ++ V+ L
Sbjct: 1916 KEISSHGLP---SDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 1972
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL------ 1612
K+W + K++ + +L+D + L++ K E++K+ +G++L
Sbjct: 1973 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2032
Query: 1613 IQNKKEDVSSIVM--------STLRELGQTWAN------------LDHMVGQLKILLKSV 1652
+ + ++++ T + WAN + H L +LLK
Sbjct: 2033 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2092
Query: 1653 LDQWSSHKVAFDK-------INSYLMEARYSLSRFRLLTG--SLEAVQVQVDNLQNLQDD 1703
+ + ++ K + +L + + ++++ EAV+ QV+ ++ + +
Sbjct: 2093 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2152
Query: 1704 LEKQERSLQKFGSITNQLLKE-CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALL 1762
L++ +Q+ +LL+E P L E++ +W L + ++ Q +
Sbjct: 2153 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2212
Query: 1763 QLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKD 1822
+++ Q + ++E + L + + ++ + T Q LL+ T K
Sbjct: 2213 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN----TQRQQVQILLQEFATRKP 2268
Query: 1823 SLFFLHELGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYET 1880
L G+ + + D S ++ +++Q +L L + + ++
Sbjct: 2269 QYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ 2328
Query: 1881 FAKSLEALEAWIVEAEEILQG------QDPSHSSDLSTIQERMEEL---KGQMLKFSSMA 1931
+ L +L + + + L + + L T Q+ +E+ K Q+ ++
Sbjct: 2329 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC 2388
Query: 1932 PDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL---QHQTFLEK 1988
DL L + Y L + ++++ + + + + + LQS Q Q
Sbjct: 2389 EDLSALVKEEY---LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2445
Query: 1989 CETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ 2048
+ W++ + EQ + IS L + H+ F + ++ + I +G+ LL +
Sbjct: 2446 FQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2504
Query: 2049 GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKW------ 2102
Q ++ L+L + W ++ ++R + + + +Y+E E L W
Sbjct: 2505 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2564
Query: 2103 -LVEVSYL--PMSG-----------------LGSVPIPLQQARTLFDEVQFKEKVFLRQQ 2142
L E+ + P G G V + A +L + ++V +
Sbjct: 2565 NLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN 2624
Query: 2143 GSYILTVE------------------------------------AGKQLLLSADSGAEAA 2166
S I V+ A +QL + G++A
Sbjct: 2625 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 2684
Query: 2167 LQAELAEIQEKWKS--ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK---LS 2221
L +Q + KS A + K+LA L KG +D L ++ T ++ LS
Sbjct: 2685 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 2744
Query: 2222 QSLPDHHEELHAE-------QMRCKELENAVGSWTDDLTQLSLL----------KDTLSA 2264
Q + + L + Q +E+ + + D+L ++ + K+T+ A
Sbjct: 2745 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 2804
Query: 2265 YI-------------------------SADDISILNERVELLQRQWEELCHQLSLRRQQI 2299
++ ++ D+ + +E L +Q +L + R +Q+
Sbjct: 2805 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 2864
Query: 2300 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQ 2354
+ F K KE L + E G + I + + K +EEI Q
Sbjct: 2865 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 2924
Query: 2355 ENKIQLQQMGERLAKASHESKASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ 2413
+ + +G+ L +++ +S +++ +E+ L VN RW+ L +A R +L+E L+ +
Sbjct: 2925 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 2984
Query: 2414 LDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
+ SL +W+ E +A KP S + ++ ++ EQ+ LQR ++ + V
Sbjct: 2985 FQDALESLLSWMVDTEELVANQKP---PSAEFKVVKAQIQEQKLLQRLLDDRKSTV---- 3037
Query: 2472 NLCEVLLHDCDACATDAE-CDSIQ--QATRNLDRRWRNICAMSMERRLKIEETWRLWQKF 2528
EV+ + + AT AE D ++ + LD RW + + R ++E + Q+F
Sbjct: 3038 ---EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3094
Query: 2529 LDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV---HECLTQLELINK 2585
+ +WL + E+ G + +E++ + +A + + ++ L Q I +
Sbjct: 3095 HETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ 3154
Query: 2586 QYRRLARENRTDSACSLKQMVHEGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSI 2644
+ L+ D + Q + +Q W +Q++ S L+ + + F +
Sbjct: 3155 SLKVLSSREDKD----MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVEL 3210
Query: 2645 LVWLTEMDLQLT--NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 2702
+ WL E+ +L+ +++ +S + + +L+ Q++I L ++Q + G +L++++
Sbjct: 3211 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTT 3270
Query: 2703 PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDL 2762
+ II+++L+ ++ +++ L D ++ L+L + L
Sbjct: 3271 GDEVLIIQDKLEAIKARYKDI-------------TKLSTDVAKTLEQALQL--ARRLHST 3315
Query: 2763 H-----WHDRSADSLLSPQ----PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 2813
H W D+ LLS + S + +P ++ ++ A +DS+
Sbjct: 3316 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL-------- 3367
Query: 2814 DLSRDLESAMSRALPSEDEEG-----QDDKDFYLRGAVGLSGDHSALESQI---RQLGKA 2865
++ SA+ +P EG +D + Y + ++ +++ I +Q +A
Sbjct: 3368 ---NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3424
Query: 2866 LDDSRFQIQQTENIIRS-------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
D I +TE + S + T +L M++L ID + + HK+
Sbjct: 3425 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDLVKSGHKI 3483
Query: 2919 ----KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLN 2974
EEE+ S + + V+ ++ + + L++++ QF
Sbjct: 3484 MTACSEEEK--------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3535
Query: 2975 SIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFT 3034
+W WL +T+ + QL L + +T+ Q ++ ++L++ + K I +N P+
Sbjct: 3536 ELWPWLTETQSIISQLPAPAL--EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3593
Query: 3035 QADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 3094
+ E +Q++ + + ++ +++ L +A+ Q FH+ +L LE I
Sbjct: 3594 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 3653
Query: 3095 RRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE 3154
R + P + + E +++ + + ++ + Q +L+ +++ + GTD
Sbjct: 3654 ERLRQ--PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI 3711
Query: 3155 AKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDV 3186
+ + V +++ + + + ++E E KLLDV
Sbjct: 3712 SAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 3744
Score = 210 bits (534), Expect = 2e-53
Identities = 462/2514 (18%), Positives = 971/2514 (38%), Gaps = 299/2514 (11%)
Query: 21 LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 80
L++++ + + + ++AEN + L A + ++ +M W++ K
Sbjct: 2404 LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQ 2457
Query: 81 NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEEL 140
N + + + + ++L+++ K+ L A + ++ E + + G E L
Sbjct: 2458 NKSHPISAKLDVLESLIKDHKDFSKTLTAQS----HMYEKTIAEGENLLLKTQGSEKAAL 2513
Query: 141 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLL 200
+ + N K +K+ E KL+ +LE+A L KEQ+ + L
Sbjct: 2514 QLQLNTIKTNWDTFNKQVKERE---NKLKESLEKA-----------LKYKEQV---ETLW 2556
Query: 201 SEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------ 254
++ + ++ ++ C E+ +A L LQ+E QH + +
Sbjct: 2557 PWIDKCQNNLEEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTAN 2607
Query: 255 NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEE 307
+++ + E E K L Q ++ ++ K N+ QE+ + R +
Sbjct: 2608 SLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ 2667
Query: 308 LAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLA--------------EGTE 353
A++ + + S K LTM L + LA +GT
Sbjct: 2668 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTS 2727
Query: 354 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSP 408
D+ ++ H ++ +C L + + + T E+ S A S +P
Sbjct: 2728 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 2787
Query: 409 VANTDASVNQD----IAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL 464
V ++ + A+ + L A D A + E P L L L
Sbjct: 2788 VGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL-VGIKRDLEAL 2846
Query: 465 QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---E 521
+ L + ++ + ++R +++ L+ S I L+ +E E + P E
Sbjct: 2847 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGME 2901
Query: 522 SQMAEHQALMDEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLA 575
++ Q M ++ ++EI LQ L + L+ + ++ + L+ L +
Sbjct: 2902 TETINQQLNMFKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVN 2958
Query: 576 ERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALS 635
R T+ K + + L+E L L R + AL + L SW++ T+ +
Sbjct: 2959 ARWKTLNKKVAQRAAQLQEAL---LHCGRFQDAL-------ESLLSWMVDTEELVANQKP 3008
Query: 636 PPKEPMDMEAQ---------LMDCQNMLVEI--------------EQKVVALSELSVHNE 672
P E ++AQ L+D + VE+ KV L +LS+ +
Sbjct: 3009 PSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3068
Query: 673 NL-LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLT 729
L KA T++ R+L+G + Q+ H+ + LN T EK + +
Sbjct: 3069 RWEALLNKAETRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPI 3118
Query: 730 ATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA- 788
TQ+ ++E +AQ + + K L Q ++ +S L+ ++SR ++ ++Q
Sbjct: 3119 GTQASKLEEQIAQHKAL----EDDIINHNKHLHQAVSIGQS-LKVLSSREDKDMVQSKLD 3173
Query: 789 ------AETSGDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFST 832
E + + ++L Q L K ED++ M W +H Q++ST
Sbjct: 3174 FSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST 3231
Query: 833 KQK-LLQNVLEQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEE 888
+ Q+ L QE +L + N LL+G+ L K + + L+ + +++
Sbjct: 3232 EGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKD 3290
Query: 889 VSSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQ 943
++ S + Q++ L ++L+ TWLD VE L + L EE
Sbjct: 3291 ITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP 3350
Query: 944 EILAKDIKEMSEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVV 996
+ L K+ K +D + N S A E G + V ED R L+ +
Sbjct: 3351 KELKKEAKNNKALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTI 3404
Query: 997 NQRCHQMKERLQQILNFQN--DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAE 1054
Q+ ++ + + F D ++ + + + K + L + +Q A+
Sbjct: 3405 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3464
Query: 1055 DGLKEFDAGIIELKRRGDKL------QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN 1108
+ L+ D I +L + G K+ + +Q ++L K+ YD + I R L +
Sbjct: 3465 EILRHKDI-IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERA 3523
Query: 1109 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILT 1168
+L +Q+ ++L L T + + E ++Q ++H++ + + H
Sbjct: 3524 QSLVNQFWETYEELWPWL-TETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 3582
Query: 1169 ETLFR---KII------SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLD 1219
+ + + +++ F++Q++ L +Q +K KR V L+ + +
Sbjct: 3583 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK---KRAVALDEAISQSTQFH 3639
Query: 1220 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 1279
+ ++ LE + + + +++ ++I+ +++ + + QP LY+ L
Sbjct: 3640 DKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQP-LYETLKQRGE 3698
Query: 1280 LLIS--------ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 1331
+I+ IS ++ +L+Q+ W + + + +L +++ ++ + L
Sbjct: 3699 EMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 3758
Query: 1332 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 1391
I ++ +D + + + +V+ A +E+D V++ G++L+
Sbjct: 3759 IVTIKDTQDFIRDLEDPGI----DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 3814
Query: 1392 -RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM 1450
+ D ++ + ++S W L +KL + + + + V W+ +
Sbjct: 3815 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 3874
Query: 1451 ENVIQKDEDNIKNSIG--YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 1508
+ + IG + + + +++ K FK + +Q+ ++ +N + + E
Sbjct: 3875 GGKLAS-----MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE- 3928
Query: 1509 KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 1568
SDK + L + W L+ + + LEG L + ++++ + L W E
Sbjct: 3929 -ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 3987
Query: 1569 LKQQHRI-GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 1627
L +Q + GD +++ L L++ + A + VE + + G LI++ + +S + +
Sbjct: 3988 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4047
Query: 1628 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSL 1687
L L Q W N+ Q K L L Q + + +L + L + L G
Sbjct: 4048 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4107
Query: 1688 EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNL 1747
E + Q++ + E +E + + Q+L C + + + +W ++
Sbjct: 4108 ETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4167
Query: 1748 LEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWI 1807
++ E+ + L L + + + + + Q E + L A+ + D V I
Sbjct: 4168 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE----QTLNVASRPSLILDTVLFQI 4223
Query: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
+ + + ++ + L + G LK I++ +S+ + Q L ++
Sbjct: 4224 DEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4283
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
SL + F ++ L W+ E+E+ L + ++D I+ ++ + K
Sbjct: 4284 GRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD-SELEIANDPDKIKTQLAQHKEFQKSL 4342
Query: 1928 SSMAPDLDRLNELGYRL----PLNDKEIK---RMQNLNRHWSLISSQTTERFSKLQSFLL 1980
+ D N G L L D +K + L W I ++ ER +KL+ LL
Sbjct: 4343 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4402
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSI 2038
F + + +++L + E +LA + + G+ ++ H+ FQ E+ R + ++
Sbjct: 4403 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL 4462
Query: 2039 IIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
+ L+E G DD +++ LS +W+ V + ++ +++ +RQ + + +
Sbjct: 4463 KRSARELIE-GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4521
Query: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158
L +WL E + G +P RTL D+ + K ++ G +L
Sbjct: 4522 LLEWLAEAEQ-TLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI 4580
Query: 2159 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF----LLKDWEKCEKGIADSLEKLR 2214
+ ++ + I+ +++ ++ +++LA L+ E E +A
Sbjct: 4581 CHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAET 4640
Query: 2215 TFKKKLSQSLPDHHEELHA---------EQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
T K + +P EE+ A E+M K+ + V T + + +L ++
Sbjct: 4641 TLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPD--VDKVTKTYKRRAADPSSLQSH 4698
Query: 2266 I----------------------SADDISILNERVELLQRQWEELCHQLSLRRQQIG--- 2300
I S I N RV LL +W+++ RR+++
Sbjct: 4699 IPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDAL 4758
Query: 2301 ---ERLNEWAVFSEK--NKELCEWLTQMESKV---------SQNGDILIEEMIE 2340
E L E+A F K+ W+ +S+V Q+G I +E I+
Sbjct: 4759 DRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFID 4812
Score = 203 bits (516), Expect = 3e-51
Identities = 501/2642 (18%), Positives = 1024/2642 (38%), Gaps = 403/2642 (15%)
Query: 2 ELDAAVQKFLEQNGQLGKP---LAKKIGKLTELHQQTIRQAENRLSKLNQAAS------- 51
+L A QK+ GQL + + I K T+ +Q +R ++LS L+ S
Sbjct: 2297 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ-YQSLLRSLSDKLSDLDNKLSSSLAVST 2355
Query: 52 HLEEYNEMLELILKWI-----EKAKVLAHGTIAWNSASQLREQYILHQT------LLEES 100
H + N+ LE K EK ++ + + ++ ++E+Y+ + +L+
Sbjct: 2356 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSF 2415
Query: 101 KEIDSELEAMTEKLQYLTSVYCTEKMSQQVA-------ELGRETEELRQMIKIRLQNLQD 153
K+++ + E +Q+L S + QQ++ + +E + I +L L+
Sbjct: 2416 KDVEQKAE---NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLES 2472
Query: 154 AAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV 213
KD K F K L A + T+ E L LK Q S + L ++ ++K
Sbjct: 2473 LIKDHKDFS---KTLTAQSHMYEKTIAEGE--NLLLKTQGSEKAALQLQLNTIKTNWDTF 2527
Query: 214 ------------QLCQSALRIPEDVVASLPL---CHAALR-------------------- 238
+ + AL+ E V P C L
Sbjct: 2528 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2587
Query: 239 LQEEASRLQHTAIQQC------NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVAT 292
LQ+E QH + + +++ + E E K L Q ++ ++ K
Sbjct: 2588 LQKEMD--QHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 2645
Query: 293 SNI-------QELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 345
N+ QE+ + R + A++ + + S K LTM L +
Sbjct: 2646 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 2705
Query: 346 EGLAE--------------GTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEE 391
LA+ GT D+ ++ H ++ +C L + + +
Sbjct: 2706 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 2765
Query: 392 GTNSEISSPPA-----CRSPSPVANTDASVNQDI----AYYQALSAERLQTDAAKIHPST 442
T E+ S A S +PV ++ + A+ + L A D A
Sbjct: 2766 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 2825
Query: 443 SASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTK 502
+ E P L L L + L + ++ + ++R +++ L+ S
Sbjct: 2826 MLATEETSPDLV-GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS-- 2882
Query: 503 MEAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSS------LAEELV 553
I L+ +E E + P E++ Q M ++ ++EI LQ L + L+
Sbjct: 2883 ---ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ-KEEIEPLQGKQQDVNWLGQGLI 2938
Query: 554 SESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYR 613
+ ++ + L+ L + R T+ K + + L+E L L R + AL+
Sbjct: 2939 QSAAKSTSTQ--GLEHDLDDVNARWKTLNKKVAQRAAQLQEAL---LHCGRFQDALE--- 2990
Query: 614 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQ---------LMDCQNMLVEI------- 657
L SW++ T+ + P E ++AQ L+D + VE+
Sbjct: 2991 ----SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3046
Query: 658 -------EQKVVALSELSVHNENL-LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD 709
KV L +LS+ + L KA T++ R+L+G + Q+ H+
Sbjct: 3047 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRN---------RQLEGISVVAQQ-FHE 3096
Query: 710 --KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 767
+ LN T EK + + TQ+ ++E +AQ + + K L Q ++
Sbjct: 3097 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKAL----EDDIINHNKHLHQAVSI 3152
Query: 768 QKSLLRSVASRGEEILIQHSA-------AETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 820
+SL + ++SR ++ ++Q E + + ++L Q L K ED++
Sbjct: 3153 GQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVE 3209
Query: 821 -MKW-ESLH--------QEFSTKQKLLQ-NVLEQEQEQVLYSRPN---RLLSGVPLYKGD 866
M W +H Q++ST+ Q + L QE +L + N LL+G+ L K
Sbjct: 3210 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLK-Q 3268
Query: 867 VPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWLDDVEE 923
+ + L+ + +++++ S + Q++ L ++L+ TWLD VE
Sbjct: 3269 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3328
Query: 924 RL--FVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPE-------NGDN 974
L + L EE + L K+ K +D + N S A E G
Sbjct: 3329 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD-SLNEVSSALLELVPWRAREGLE 3387
Query: 975 RDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 1034
+ V ED R L+ + Q+ ++ + +
Sbjct: 3388 KMVAEDN-----ERYRLVSDTITQKVEEIDAAILR------------------------- 3417
Query: 1035 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 1094
+ F+Q ++ I + E L +E + +LQV++ E+ + +D+ D+L
Sbjct: 3418 -SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3476
Query: 1095 MMIIGSRRSGLNQN--LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 1152
+ + ++ ++K + ++ L++ + + E+ E Q L++
Sbjct: 3477 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYL--------QLERAQSLVN 3528
Query: 1153 KHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYIL 1212
+ E ++ L LTET + IIS +L A A LEY
Sbjct: 3529 QFWETYEELWPW--LTET--QSIIS-----------QLPAPA-------------LEY-- 3558
Query: 1213 ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQ 1272
ET QQE RQL L+ E++ + +N+ P+L +
Sbjct: 3559 ETL----RQQQEEHRQLRE---------LIAEHKPHI-----------DKMNKTGPQLLE 3594
Query: 1273 VLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLI 1332
L G+ I ++ +Q+ E + K L+ + T++ + ++
Sbjct: 3595 -LSPGEGFSIQEKYVAADTLYSQIKE-------DVKKRAVALDEAISQSTQFHDKIDQIL 3646
Query: 1333 HWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR 1392
L+ +RL +Q ++ E+E +++ ++ S +++ L ++ G +++
Sbjct: 3647 ESLERIVERL----RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 3702
Query: 1393 L-----KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 1447
K + ++ +L ++ W ++ T + + KL L + +L + MS I
Sbjct: 3703 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKL--LDVMELAEKFWCDH-MSLI 3759
Query: 1448 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVE 1507
+++ D I + + + + + +I+ Q +D V + + S+ +
Sbjct: 3760 VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIV----INLGSELIA 3815
Query: 1508 S-KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 1566
+ DK + + +N +W L ++I LE +++ +Y++ +Q + W +
Sbjct: 3816 ACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 3875
Query: 1567 KRLKQQHRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSS-IV 1624
+L IG D +V+ +++ + + ++ E+E++ L++ E+ V
Sbjct: 3876 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTV 3935
Query: 1625 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLT 1684
L EL W +L+ + + L+ L + A D++ ++L LS + +
Sbjct: 3936 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 3995
Query: 1685 GSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRW 1744
G +A+++++ LQ+D+ + +++ N L++ L N L+ +N RW
Sbjct: 3996 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4055
Query: 1745 NNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN---KDIADD 1801
N+LE+ ++ Q L+ + K + + Q D LL + + A +
Sbjct: 4056 QNVLEKTEQRKQQLDGALR---QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKE 4112
Query: 1802 EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE 1861
++ ++ C T K L + G+Q+ + SA + I D +L + ++E
Sbjct: 4113 QLNVHMEVCAAFEAKEETYKS----LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4168
Query: 1862 QALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELK 1921
L +++T L+ + F SL+ W+ +AE+ L S L T+ +++E K
Sbjct: 4169 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP-SLILDTVLFQIDEHK 4227
Query: 1922 GQMLKFSSMAPDLDRLNELGYRLPL--NDKEIKRMQNL----NRHWSLISSQTTERFSKL 1975
+ +S + L++ G L +++ ++NL W + + ER L
Sbjct: 4228 VFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL 4287
Query: 1976 QSFLLQHQTFLEKCETWMEFLVQTEQKL--AVEISGNYQHLLEQQRAHELFQAEMFSRQQ 2033
+ + F E ME+L ++E+ L +EI+ + + Q H+ FQ + ++
Sbjct: 4288 DDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHS 4347
Query: 2034 ILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRY 2092
+ + G+ L E+ + DD + + L+ L ++W + ++ +R+ ++ + ++
Sbjct: 4348 VYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4407
Query: 2093 REMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAG 2152
+ + L WL V ++ V + L D K F ++ G +V+A
Sbjct: 4408 TDALQALIDWLYRVEP-QLAEDQPVHGDIDLVMNLIDN----HKAFQKELGKRTSSVQAL 4462
Query: 2153 KQL---LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADS 2209
K+ L+ + ++ ++ E+ +W++ ++ +L L+ E+ +
Sbjct: 4463 KRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL 4522
Query: 2210 LEKLRTFKKKLSQS--LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS 2267
LE L ++ L LPD + L + KE + +L + + + DT+ A
Sbjct: 4523 LEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICH 4582
Query: 2268 ADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV 2327
D I+ + + +++ ++EE+ +Q++ L E + L WL E+ +
Sbjct: 4583 PDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTL 4642
Query: 2328 SQNGDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAK-----ASH---- 2372
+ +I + IE++K + + EE+ Q + ++ + +R A SH
Sbjct: 4643 TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVL 4702
Query: 2373 -----------------ESKASEIEYKLGKVN---DRWQHLLDLIAARVKKLKETLVAVQ 2412
++IE K +VN +WQ + L R +KL + L ++
Sbjct: 4703 DKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLE 4762
Query: 2413 QL 2414
+L
Sbjct: 4763 EL 4764
Score = 182 bits (462), Expect = 5e-45
Identities = 617/3357 (18%), Positives = 1313/3357 (39%), Gaps = 415/3357 (12%)
Query: 28 LTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLR 87
L L IR+ + S L+Q + E + ++ +L W+++ +V T W S
Sbjct: 250 LQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT-EWGSDLPSV 308
Query: 88 EQYIL-HQTLLEESKEIDSEL-EAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIK 145
E ++ H+ + +E +S L EA ++Q + T ++++ L + +L +
Sbjct: 309 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT--YAEKLHRLESQYAKLLNTSR 366
Query: 146 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMES 205
+ ++L + + EL L E+ A S ++ K+ + L+ E++
Sbjct: 367 NQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKD--YHAELMRELDQ 424
Query: 206 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ-- 263
+ +++VQ L + E+ A L + +Q + S + +Q C ++ + +
Sbjct: 425 KEENIKSVQEIAEQLLL-ENHPARLTIEAYRAAMQTQWSWI----LQLCQCVEQHIKENT 479
Query: 264 -YEQYEQEMKHLQQLIEGAHREIEDKPVA--TSNIQELQAQISRHEELAQKIKGYQEQIA 320
Y ++ + K + I+ K +S+I +L+ + E +++ Y+ IA
Sbjct: 480 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 539
Query: 321 SLNSKCK-MLTMKAKHATM-LLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 378
+L K K ++ +K +++ L T ++ + + + + + + A H
Sbjct: 540 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI-------EITIYKDDECVLANNSH 592
Query: 379 TLLSPVTEESGEEGTNSEI--SSPPACRSPSPVANTDASVNQDIAYY---------QALS 427
V +G E + + PP + +AN Q++ +S
Sbjct: 593 RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 652
Query: 428 AERLQTDAAKIHPSTSAS----------------QEFYEPGLEPSATAKL--GDLQRSWE 469
L + +I S AS Q +E LE S +++ G E
Sbjct: 653 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 712
Query: 470 TLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPE----PGRSP----- 520
NV + + L ++ ER+++ + +++ I L+L + R+P
Sbjct: 713 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 772
Query: 521 --ES--QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 576
ES ++ E + L E+ L+D++ + + EE S++ + L+S L V+ +
Sbjct: 773 LHESVFRITEQEKLKKELERLKDDLGTITNK-CEEFFSQAAASSSVP--TLRSELNVVLQ 829
Query: 577 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 636
M+ + +S L+ Q E ++ Y + E ++ +++ K ++ +S
Sbjct: 830 NMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA-VIADKNNIENLIST 888
Query: 637 PKEPMDMEAQLMDCQNMLVEIEQKVVALS-ELSVHNENLLLEGKAHTKDEAEQLAGKLRR 695
K+ + + L + QK A+S E+ + L+ H K++A+QL + R
Sbjct: 889 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH-KEKADQL---VER 944
Query: 696 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSL 755
+ +++ L D ++G + + T P + +W+ Q TT + +++
Sbjct: 945 WQNVHVQIDNRLRD----LEGIGKSLKY----YRDTYHP-LDDWIQQVETTQRKIQENQP 995
Query: 756 QQQKELEQELAEQKSLLRSVASRGEEI-LIQHSAAETSGDAGE-KPDVLSQELGMEGEKS 813
+ K L +L +QK L+ + + ++ Q A + S + + ++ ++ ++
Sbjct: 996 ENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1055
Query: 814 SAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS 873
S + RM+ S+ ++Q ++ L +R L++ + Y K
Sbjct: 1056 SPVKRRRMQ--------SSADLIIQEFMD------LRTRYTALVTLMTQY-------IKF 1094
Query: 874 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLP 933
A SL + EE K++ + ++L VS S L D E+ A P
Sbjct: 1095 AGDSL-----KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK------AGKP 1143
Query: 934 EETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 993
++ + ++EI K KE E + LF ++GD + D
Sbjct: 1144 PFSKQKISSEEISTK--KEQLSEALQTIQLF---LAKHGD----------------KMTD 1182
Query: 994 SVVNQRCHQMKERLQQILN--FQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQ 1051
N+ Q+K LQ+ N F LK L S + +K+ +Q E+++ I
Sbjct: 1183 EERNELEKQVK-TLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGIC 1241
Query: 1052 QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111
+ G E GD EL K Q +EL + L +
Sbjct: 1242 DLLTQTENRLIGHQEAFMIGD-------GTVELKKYQSKQEELQKDMQGSAQALAE---- 1290
Query: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 1171
+++ + L+ EK++ + K + I+Q L++ K + L ++
Sbjct: 1291 ------VVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLNLKAEQSKKE 1338
Query: 1172 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL-SRQLE 1230
K+++ A+++ET + A +K+ + ++E +L+ S++D+D + ++ +
Sbjct: 1339 LDKVVTTAIKEET--------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQ 1390
Query: 1231 VVESS---------IPSVGLVEENEDRLIDRI------TLYQHLKSSLNEYQPKLYQVLD 1275
V+E + ++G +E L++ T ++L + + + +++
Sbjct: 1391 VIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIIS 1450
Query: 1276 DGKRLLISISCSD--LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIH 1333
+ ++I+ + LE Q L K+ K + L+ + + L H
Sbjct: 1451 QHQAVIIATQSAQVLLEKQGQYLSP---EEKEKLQKNMKELKVHYETALAESEKKMKLTH 1507
Query: 1334 WLQSAKDR-------LEFWTQQSVTVPQELEMVRDHLNAFL-------EFSKEVDAQSSL 1379
LQ ++ E W QQS + LE D +N + FS++V +
Sbjct: 1508 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1567
Query: 1380 KSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 1439
+ +GN++L K S+ D D VQ KL D+ S ++
Sbjct: 1568 LRYITISGNRVLEAAK--------SCSKRDGGKVDTSATHREVQRKLDH-ATDRFRSLYS 1618
Query: 1440 ISEVM--SWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQS 1497
V+ + L++ ++ + G +A K+ I ++ K L
Sbjct: 1619 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 1678
Query: 1498 VL--QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 1555
L QISSQ V ++ KT AE L S + + + + + G E S+ N
Sbjct: 1679 ALQGQISSQQVAVEKLKKT--AEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN-- 1734
Query: 1556 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 1615
E+ K Q + SVQ+ L + D +++ KE ++ N AL
Sbjct: 1735 ----------ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL--- 1781
Query: 1616 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV-LDQWSSHKVAFDKINSYLMEAR 1674
+D+ S + +++ ++++ M ++K +++ SS + +++ EA
Sbjct: 1782 --QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEAS 1839
Query: 1675 YSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP---VTE 1731
+ + + +E ++ +V+ +NL + LQ F Q L E P VTE
Sbjct: 1840 H---KHKETLAKMEELKTKVELFENLSE-------KLQTFLETKTQALTEVDVPGKDVTE 1889
Query: 1732 TLTNTLKEVNMRW----------NNLLEEIAEQ-LQSSKAL-LQLWQRYKDYSKQCASTV 1779
L+ ++E + ++LL+EI+ L S KAL L+ K+ T+
Sbjct: 1890 -LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTI 1948
Query: 1780 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 1839
+++++ + + + +WI++ K + V+ S F +LG+ L+
Sbjct: 1949 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETT---KKVPIVQPS-FGAEDLGKSLEDTKK 2004
Query: 1840 ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL 1899
++++ ++ Q + SL + T AK++ A+++ +L
Sbjct: 2005 LQEKWSLKTPEI----------QKVNNSGISLCNLISAVTTPAKAIAAVKS----GGAVL 2050
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNR 1959
G+ + +++ + + +K M S DL L L DK + LN
Sbjct: 2051 NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLL--------LKDK----IAELNT 2098
Query: 1960 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQR 2019
S + E + +Q ++T W + T+ + AV+ +EQ +
Sbjct: 2099 KLSKLQKAQEESSAMMQWLQKMNKT----ATKWQQTPAPTDTE-AVKTQ------VEQNK 2147
Query: 2020 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
+ E + ++ Q L + + L E + + LT + ++WQ + + R+
Sbjct: 2148 SFEAELKQNVNKVQELKDKLT--ELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2205
Query: 2080 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 2139
++ +++ + +L++WLVE L +S LG + I T +VQ + F
Sbjct: 2206 QKLEESSNNLTQFQTVEAQLKQWLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2264
Query: 2140 RQQGSYILTVEAGKQLLL--SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 2197
++ Y AG+ +L D ++ +LA + +KW S + +L ++ + +
Sbjct: 2265 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2324
Query: 2198 DWEKCEKGIADSLEKLRTFKKKLSQSL--PDHHEELHAEQMRCKELENAVGSWTDDLTQL 2255
+ + + +KL KLS SL H + ++ + ++++ + +
Sbjct: 2325 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2384
Query: 2256 SLLKDTLSAYISADDISI-LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK 2314
L + LSA + + + L+ ++E + + ++++ + Q + F + ++
Sbjct: 2385 QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSR 2444
Query: 2315 ELCEWLTQMESKVSQNGDILIE-EMIEKLKKDYQE--EIAIAQENKIQLQ-QMGERLAKA 2370
+ WL + + +++ I + +++E L KD+++ + AQ + + GE L
Sbjct: 2445 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2504
Query: 2371 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 2430
+ S+ + ++ +L + W + R KLKE+L + + + +L W+ ++
Sbjct: 2505 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2564
Query: 2431 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD---ACATD 2487
L + + + E + + + + LQ+++++H V + N LL C+ TD
Sbjct: 2565 NLEE--IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2622
Query: 2488 AECDSIQQATRNLDR-RWRNICAMSMERRLK-IEETWRLWQKFLDDYSRFEDWLKSSERT 2545
IQ+ ++ + C +M ++ K +E + ++ L D + S +
Sbjct: 2623 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD-IHDSLGS 2681
Query: 2546 AAFPSSSGVIYTVAKEELKKFEAFQRQV--------------------HECLTQLELINK 2585
A+ S T+ + + K +A + QV + L Q+E I +
Sbjct: 2682 QAY---SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQ 2738
Query: 2586 QYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSIL 2645
++ L+++ D CS + +G + N ++ Q EF+ DS
Sbjct: 2739 EHSTLSQQ--VDEKCSFLETKLQGIGHFQN----------TIREMFSQFAEFDDELDS-- 2784
Query: 2646 VWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 2705
+ + ++ E ++A +K+L+A + + ++A E++ P D
Sbjct: 2785 --MAPVGRDAETLQKQKE-TIKAFLKKLEALMASNDNANKTCKMMLA-----TEETSP-D 2835
Query: 2706 AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 2765
I+ +L+ L + C ++ R + +++ +E +E S L H
Sbjct: 2836 LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF----SILLQKAEEH 2891
Query: 2766 DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR 2825
+ S + + N L++ + + E P + W L + L + ++
Sbjct: 2892 EESQGPVGMETETINQQLNMFKVFQKEEI---EPLQGKQQDVNW-----LGQGLIQSAAK 2943
Query: 2826 ALPSED-EEGQDDKDFYLRGAVGLSGDHSA-LESQIRQLGK---ALDDSRFQIQQTENII 2880
+ ++ E DD + + +A L+ + G+ AL+ + TE ++
Sbjct: 2944 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3003
Query: 2881 RSKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST 2934
++ P E K +LL + S+++ +KR K+ E L
Sbjct: 3004 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL--- 3060
Query: 2935 ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE 2994
Q + + RWE L +A ++ +++ QQF+ L + WL E+ L +
Sbjct: 3061 -KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE--P 3117
Query: 2995 LSTDIQTIELQIKKLKELQ-KAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQMN 3052
+ T +E QI + K L+ ++H K + ++++ S+E +D+ Q +L
Sbjct: 3118 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQ 3176
Query: 3053 GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL 3112
+ + LLQ AL + F E L+ L + + +++ D E L
Sbjct: 3177 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD--YSTEGL 3234
Query: 3113 QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKE 3172
+L ++ ++L + V +LL G + L ++K+ I R K + K
Sbjct: 3235 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3294
Query: 3173 VSRHIKELEKLLDVS----SSQQDLSSWSSADELD-TSGSVSPTSGRSTPNRQKTPR 3224
+ K LE+ L ++ S+ ++L +W E++ S G Q P+
Sbjct: 3295 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3351
Score = 96.3 bits (238), Expect = 5e-19
Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)
Query: 1330 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 284 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 336
Query: 1387 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 1446
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 337 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 388
Query: 1447 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 1506
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 389 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 440
Query: 1507 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 1565
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 441 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 498
Query: 1566 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 1623
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 499 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 551
Query: 1624 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 1678
+T + + +I + D +SH+ + I+ EA
Sbjct: 552 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 611
Query: 1679 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 1732
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 612 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 671
Query: 1733 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 1777
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 672 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 731
Query: 1778 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 1817
Q++ EDR ++ +D + V I + L K L
Sbjct: 732 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 790
Query: 1818 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 1877
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 791 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 847
Query: 1878 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 1931
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 848 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 907
Query: 1932 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 1980
+L + + + KE ++ L W + Q R L+ L
Sbjct: 908 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 967
Query: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 968 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1023
Query: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1024 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1068
Query: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
+ E L V + Q + D ++ E+
Sbjct: 1069 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1104
Query: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 2216
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1105 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1158
Query: 2217 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 2274
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1159 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1206
Query: 2275 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 2330
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1207 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1258
Query: 2331 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 2376
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1259 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1318
Query: 2377 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 2429
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1319 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1378
Query: 2430 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 2454
SE A K ++ S EE Q LN+Q
Sbjct: 1379 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1438
Query: 2455 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 2509
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1439 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1497
Query: 2510 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 2568
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 1498 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1556
Query: 2569 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 2616
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 1557 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1616
Query: 2617 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 2670
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 1617 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 1674
Query: 2671 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 2728
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 1675 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 1734
Query: 2729 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 2784
++KL ++ L R L ++D L W SL P S+ L
Sbjct: 1735 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 1784
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 2843
+++ + E+ +S+++ ++ ++ M PS Q KD R
Sbjct: 1785 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 1834
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 2903
+ S H +++ +L ++ ++ + + +KT E+D K +L
Sbjct: 1835 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 1893
Query: 2904 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 2962
S LEHK E SL ++ H + A V+++ L + E +K+
Sbjct: 1894 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 1951
Query: 2963 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 2999
++ F + S+ +W+ +T ++ LE ++L+ +
Sbjct: 1952 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2011
Query: 3000 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 3044
+T E+Q L L AV I ++ + + E T +++E +
Sbjct: 2012 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2071
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
+ ++ ++ ++ + LL++ L L + Q E S ++ L+ +++ +
Sbjct: 2072 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2131
Query: 3105 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 3164
+ D E ++ +Q + EL ++ +V L+D +LL E D EA
Sbjct: 2132 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2181
Query: 3165 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 3209
R K +L E+ +EL +L L+ SS+ + L W EL S +
Sbjct: 2182 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2240
Query: 3210 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 3269
P S PN T R + + + P LS PG S RG + L
Sbjct: 2241 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2298
Query: 3270 RA 3271
A
Sbjct: 2299 AA 2300
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 215 bits (547), Expect = 7e-55
Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)
Query: 1256 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 1315
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 766 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 816
Query: 1316 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 1372
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 817 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 868
Query: 1373 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 1430
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 869 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 927
Query: 1431 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 1487
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 928 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 984
Query: 1488 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 1546
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 985 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1040
Query: 1547 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 1605
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 1041 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1100
Query: 1606 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 1665
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 1101 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1160
Query: 1666 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 1725
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1161 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1220
Query: 1726 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 1785
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1221 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1280
Query: 1786 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 1845
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1281 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1330
Query: 1846 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 1904
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1331 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1389
Query: 1905 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 1960
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1390 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1449
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 2020
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1450 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1495
Query: 2021 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1496 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1554
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 2136
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1555 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1612
Query: 2137 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 2196
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1613 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1670
Query: 2197 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 2247
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1671 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1725
Query: 2248 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 2307
D L + + IS LN R + + H++ + I L E
Sbjct: 1726 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1776
Query: 2308 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 2367
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1777 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1826
Query: 2368 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 2426
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1827 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1886
Query: 2427 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 2485
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1887 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1934
Query: 2486 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 2527
E IQ L +RWR I + RRL EET + +
Sbjct: 1935 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1989
Query: 2528 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 2581
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1990 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2045
Query: 2582 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 2046 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2105
Query: 2642 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 2106 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2164
Query: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 2758
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2165 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2224
Query: 2759 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 2815
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2225 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2283
Query: 2816 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 2862
L+ +SRALP E Q + + ++ L LE Q+ L
Sbjct: 2284 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2339
Query: 2863 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 2905
+ + F +Q+TE +++K P E+ + + + L + S
Sbjct: 2340 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2399
Query: 2906 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 2964
S +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK L M +L
Sbjct: 2400 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2458
Query: 2965 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 3022
+D N W L D L+Q+ + + + D++ I I K K + ++ R+
Sbjct: 2459 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2518
Query: 3023 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 3076
+ + + + ++E+R + DR+ ++ +WD V L+ R +L+D+
Sbjct: 2519 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2578
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
+ E L ++ K +D+ +Q + Q+ +L + Q V
Sbjct: 2579 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2632
Query: 3137 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 3185
D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2633 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2677
Score = 191 bits (486), Expect = 8e-48
Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)
Query: 1122 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 1180
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 388 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 446
Query: 1181 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 1239
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 447 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 506
Query: 1240 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 1285
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 507 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 566
Query: 1286 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 1345
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 567 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 623
Query: 1346 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 1402
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 624 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 683
Query: 1403 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 1459
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 684 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 739
Query: 1460 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 1518
I G + +K + + K + ++S + Q V E +D A
Sbjct: 740 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 797
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 1570
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 798 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 847
Query: 1571 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 1628
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 848 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 907
Query: 1629 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 1688
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 908 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 965
Query: 1689 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 1748
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 966 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1025
Query: 1749 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 1808
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 1026 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1081
Query: 1809 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 1865
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 1082 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1138
Query: 1866 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 1925
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1139 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1197
Query: 1926 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 1978
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1198 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1257
Query: 1979 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 2036
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1258 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1313
Query: 2037 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 2096
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1314 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1371
Query: 2097 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 2155
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1372 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1418
Query: 2156 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 2212
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1419 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1469
Query: 2213 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 2270
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1470 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1529
Query: 2271 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 2330
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1530 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1589
Query: 2331 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 2384
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1590 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1646
Query: 2385 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 2444
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1647 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1695
Query: 2445 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 2504
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1696 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1737
Query: 2505 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 2563
+ C +E ++ SE F + S I T A L
Sbjct: 1738 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1772
Query: 2564 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 2618
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1773 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1828
Query: 2619 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 2678
R+T + K +++K QQ
Sbjct: 1829 RITD--------------------------------------------ERKREEIKIKQQ 1844
Query: 2679 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 2738
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1845 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1896
Query: 2739 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 2798
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1897 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1952
Query: 2799 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 2858
L + + + + M+ +P E +S S ++
Sbjct: 1953 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 1995
Query: 2859 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
I + +AL +++Q N P+L C+ + + + E L
Sbjct: 1996 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 2030
Query: 2919 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 2958
K ++SL G ++ +HS +T Q+A ++R WE + ++ R
Sbjct: 2031 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2090
Query: 2959 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 3017
++++KW++F+ D+ WL + E+ L + Q E + K LKELQ +
Sbjct: 2091 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2145
Query: 3018 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 3076
R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2146 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2205
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
F + +L LE D + +P++ + + L++ +Q+ + EL Q + L
Sbjct: 2206 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2262
Query: 3137 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 3183
+ +LV+A E D LE K K + L E+ IK+L +KL
Sbjct: 2263 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2322
Query: 3184 LDVSSSQQDLSSWSS 3198
D+ L W S
Sbjct: 2323 EDLEEQLNHLLLWLS 2337
Score = 187 bits (474), Expect = 2e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 454 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 512
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 409 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 468
Query: 513 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 570
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 469 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 524
Query: 571 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 628
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 525 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 572
Query: 629 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 685
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 573 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 632
Query: 686 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 737
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 633 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 688
Query: 738 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 783
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 689 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 748
Query: 784 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 827
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 749 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 808
Query: 828 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 875
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 809 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 866
Query: 876 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 909
+ L GL E + QS K + + H +Q D
Sbjct: 867 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 926
Query: 910 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 955
+SA TW+ E +L + + E E L + L ++E
Sbjct: 927 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 986
Query: 956 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 1007
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 987 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1039
Query: 1008 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 1066
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 1040 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1099
Query: 1067 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 1120
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 1100 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1159
Query: 1121 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 1176
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1160 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1218
Query: 1177 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 1230
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1219 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1275
Query: 1231 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 1286
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1276 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1325
Query: 1287 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1326 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1382
Query: 1347 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 1395
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1383 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1442
Query: 1396 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 1438
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1443 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1502
Query: 1439 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 1480
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1503 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1562
Query: 1481 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 1510
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1563 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1622
Query: 1511 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 1557
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1623 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1682
Query: 1558 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 1610
+ W + L + + K Q ED++K + E V+
Sbjct: 1683 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1731
Query: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 1668
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1732 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1791
Query: 1669 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 1722
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1792 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1846
Query: 1723 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 1782
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1847 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1888
Query: 1783 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1889 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1933
Query: 1843 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 1882
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1993
Query: 1883 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 1940
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 1994 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2053
Query: 1941 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 1997
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 2054 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2113
Query: 1998 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 2056
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 2114 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2172
Query: 2057 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 2116
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2173 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2227
Query: 2117 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 2171
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2228 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2287
Query: 2172 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 2228
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2288 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2347
Query: 2229 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 2286
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2348 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2405
Query: 2287 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 2308
L +L ++ + L E A+
Sbjct: 2406 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2465
Query: 2309 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 2362
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2466 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2521
Query: 2363 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 2411
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2522 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2581
Query: 2412 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2582 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2633
Query: 2472 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 2531
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2634 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2689
Query: 2532 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2690 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2744
Query: 2581 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 2639
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2745 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2804
Query: 2640 ARDSILVWLTEMDLQLT 2656
+ +LVWL D +L+
Sbjct: 2805 SLQELLVWLQLKDDELS 2821
Score = 179 bits (453), Expect = 5e-44
Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)
Query: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 537
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 325 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 384
Query: 538 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 597
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 385 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 442
Query: 598 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 655
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 443 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 490
Query: 656 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 700
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 491 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 550
Query: 701 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 760
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 551 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 597
Query: 761 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 819
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 598 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 639
Query: 820 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 879
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 640 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 688
Query: 880 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 936
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 689 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 737
Query: 937 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 986
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 738 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 797
Query: 987 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 1038
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 798 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 853
Query: 1039 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 1094
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 854 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 913
Query: 1095 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 1146
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 914 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 973
Query: 1147 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 1202
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 974 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1033
Query: 1203 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 1262
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 1034 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1089
Query: 1263 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 1319
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 1090 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1149
Query: 1320 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 1378
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1150 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1207
Query: 1379 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 1438
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1208 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1265
Query: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1266 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1314
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 1558
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1315 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1374
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 1609
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1375 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1432
Query: 1610 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 1666
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1433 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1471
Query: 1667 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 1726
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1472 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1526
Query: 1727 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 1786
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1527 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1583
Query: 1787 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 1843
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1584 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1637
Query: 1844 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 1899
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1638 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1694
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 1953
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1695 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1748
Query: 1954 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 2012
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1749 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1806
Query: 2013 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 2072
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1807 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1854
Query: 2073 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 2132
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1855 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1903
Query: 2133 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 2192
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1904 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1961
Query: 2193 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 2242
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1962 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2021
Query: 2243 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 2289
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 2022 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2081
Query: 2290 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 2344
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 2082 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2138
Query: 2345 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 2404
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2139 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2198
Query: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 2464
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2199 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2256
Query: 2465 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 2519
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2257 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2312
Query: 2520 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 2561
+ +L +K D + WL + F I AK+
Sbjct: 2313 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2372
Query: 2562 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 2610
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2373 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2431
Query: 2611 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 2659
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2432 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2491
Query: 2660 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 2718
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2492 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2551
Query: 2719 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 2778
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2552 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2611
Query: 2779 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 2834
+ LA+ LR +W + D++ DL + R ++D
Sbjct: 2612 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2654
Query: 2835 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 2887
++ + +S +ALE R L + LD +F + + T N+++ T
Sbjct: 2655 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2714
Query: 2888 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 2941
L+ S K + L GE + D L+ ++ SL G + + + +
Sbjct: 2715 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2774
Query: 2942 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 3001
+W L+ ++L+ ++ + +W++ + L + WL ++EL + + + D
Sbjct: 2775 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2832
Query: 3002 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 3040
++ Q + ++ + ++ +I+S F E
Sbjct: 2833 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2892
Query: 3041 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 3100
+R L+ + ++N W+++ +W+ + + L + Q E + L L L + K
Sbjct: 2893 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2952
Query: 3101 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 3143
P+ +L + LQDH +++ ++ E+ + V+ + D++ QL
Sbjct: 2953 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2994
Score = 179 bits (453), Expect = 5e-44
Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)
Query: 1323 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 1382
RYQ+ +++ WL SA+D L Q + ++E+V+D + + ++ A +
Sbjct: 335 RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 390
Query: 1383 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 1439
+L G++L+ +L + + ++ +++ ++S+W L Q LH++ MD
Sbjct: 391 ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 448
Query: 1440 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 1499
+ E+ W++ E +K E+ + + +Q++K + D+ +Q+ V+ + V+
Sbjct: 449 LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 507
Query: 1500 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 1559
+ D S EQL + W + ++ LL+ +L W
Sbjct: 508 VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 564
Query: 1560 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 1614
W +E + + H G DQ + ++L+ L+ ++ K++ + K+ +Q+ L+ ++
Sbjct: 565 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 624
Query: 1615 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 1645
NK +S V +T L QT + + +
Sbjct: 625 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 684
Query: 1646 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 1693
+IL+K ++ ++ D +++ + E ++R + S E A+ +
Sbjct: 685 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 744
Query: 1694 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 1742
N +L++ + ER +KF ++ Q++ E +++ +++N
Sbjct: 745 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 802
Query: 1743 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 1799
RW + ++E+L W Y++ + +QQ E T LK
Sbjct: 803 RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 854
Query: 1800 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859
+ + ++ C D + L ++ + L LK++ + +D ++ + H
Sbjct: 855 PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 912
Query: 1860 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 1917
+ + ++ LQ L + +++ A+ W+ ++E L S +D +++R+
Sbjct: 913 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 971
Query: 1918 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 1971
EL+ L L+ E+ + P ++ K + + W +SSQ E
Sbjct: 972 GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 1031
Query: 1972 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 2029
KL+ + + + +T +++ + + L E G+ + L +Q + L +++
Sbjct: 1032 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1091
Query: 2030 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 2089
+ Q L+S+ GQ++ + + + +L L+ QW + ++ R+ + + +
Sbjct: 1092 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1151
Query: 2090 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 2147
++ ++ +W+ E YL P LQ+A +E++ ++ +++ L
Sbjct: 1152 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1208
Query: 2148 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 2207
E+ ++ A A+ AL+ EL + ++ RL + K L + W + +
Sbjct: 1209 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1268
Query: 2208 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
+ + L FK K ++++P EE+ LEN + D+ Q+ +L TL+
Sbjct: 1269 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1325
Query: 2266 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 2325
D++ +NE +E +W EL H+ ++RRQ++ E+ + A +EK+ L
Sbjct: 1326 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1373
Query: 2326 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 2380
I+E + + K IA +K+ QM + K SHE E++
Sbjct: 1374 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1420
Query: 2381 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 2434
K + + Q +L I KKL++ + + K + + L ++ L
Sbjct: 1421 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1479
Query: 2435 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 2494
+ S E +Q +LN L + + + + V V+ ++ +
Sbjct: 1480 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1534
Query: 2495 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 2554
+ L + + A ER+ ++E+ +L +K + + +WL +++ S+
Sbjct: 1535 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1594
Query: 2555 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 2609
+ + E+ +A Q+++ + L+ I + L +E + SL
Sbjct: 1595 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1648
Query: 2610 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 2669
N W + R L L + E F+ D I W+ + D L E +
Sbjct: 1649 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1708
Query: 2670 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 2729
+K+LKA +I K++ Q L+ ++E ++ EL + R++
Sbjct: 1709 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1765
Query: 2730 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 2784
+ L D L E E++ L + ++ D + D+ + + +
Sbjct: 1766 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1825
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 2843
L Q + ER + + + ++ +DL S +AL + Q Y R
Sbjct: 1826 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1876
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 2903
A L +E ++ L + D+ + I++ + ++ K + +G + G
Sbjct: 1877 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1933
Query: 2904 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 2963
+ + +L + +E E F L+ + T V + ++ + + E+ +
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1991
Query: 2964 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 3023
+ +++ + L + E+ L + D + + Q + LK ++ ++ I
Sbjct: 1992 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 2044
Query: 3024 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 3080
I+ Q+ + R LQ+ LSQ++ +W++V + ++ +G ++ + + FH
Sbjct: 2045 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2104
Query: 3081 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 3139
++ + L E R+ I N + + + K+L + + Q V +L
Sbjct: 2105 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2157
Query: 3140 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 3198
+++ + TD +EK+ + R + + K++S K LE+ ++ S Q+DL+ +
Sbjct: 2158 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2217
Query: 3199 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 3226
+E D S+ G+ ++K + K
Sbjct: 2218 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2246
Score = 164 bits (415), Expect = 1e-39
Identities = 486/2595 (18%), Positives = 999/2595 (38%), Gaps = 339/2595 (13%)
Query: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
E+ +++QK L K + +GKL L Q + +N+ S + + L+ + +
Sbjct: 587 EMLSSLQKLAVLKADLEKK-KQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWD 644
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
+++ +EK S +Q+ + Q L + T ++ +T+V
Sbjct: 645 NLVQKLEK------------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVT 681
Query: 122 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTS 181
E++ + A+ EEL + + + ++ K+ + ++ +L + + +++A L S
Sbjct: 682 TREQILVKHAQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS 736
Query: 182 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQ 240
PE + S + ++ +E + K + + Q A R + +V + A ++
Sbjct: 737 PEFAIFRKEGNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK 794
Query: 241 EEASRLQHTAIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSN 294
+ + +L I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S
Sbjct: 795 QASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 854
Query: 295 IQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTED 354
+++Q+ ++ ++ G Q QI L K + + +K K +G
Sbjct: 855 PTAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMF 898
Query: 355 LDGELLPTPSAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSP 408
LD + + + V R L L P+ + + + S
Sbjct: 899 LDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQ 958
Query: 409 VANTDASV-NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQ 465
++ TD + Q + QAL + + + + ST+ + + E S ++ +++
Sbjct: 959 LSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1018
Query: 466 RSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ES 522
W+ L + + E + L E + + +K Q+ +Q++ M +++ L E P G S +
Sbjct: 1019 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKK 1078
Query: 523 QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIR 582
Q+ + + L+ +I +Q +N + +++ +E A+P L++ L L + +
Sbjct: 1079 QLKQCRLLVSDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMC 1134
Query: 583 MKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKE 639
+ +++ L+ L + Q+ + + +A+E + T L A+ K
Sbjct: 1135 QQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR 1194
Query: 640 PMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGS 699
+ Q +L E V+A + V E L E + T + + L +L +
Sbjct: 1195 AKEEAQQKEAKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKT 1252
Query: 700 LLELQRALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQ 758
L E+ H+ ++ + E + L T++ PG E
Sbjct: 1253 LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE-------------------- 1292
Query: 759 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ 818
E+ + L ++L+R +I I A+T D G +++++EL +
Sbjct: 1293 -EISEVLDSLENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ET 1338
Query: 819 MRMKWESLHQEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVPT- 869
+W LH+E +QKLL+ ++ QE Q + ++ L+ K D
Sbjct: 1339 FNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQM 1398
Query: 870 -QDKSAVTSLLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---D 920
Q+ + S L + EE+ + G + I + QK VS +
Sbjct: 1399 PQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 1458
Query: 921 VEERLFVATALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLF 964
E+RL + +L E ET QE+ L K + E+ E++
Sbjct: 1459 FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 1518
Query: 965 SQAFPENG-DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 1023
Q + +N +++ + L + L + V +R Q+++ L+ + ++ VL
Sbjct: 1519 RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 1578
Query: 1024 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 1083
LA + ++ A E + + + KE + + LK +V +
Sbjct: 1579 LAATDMELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTV 1633
Query: 1084 LSKLQDMYDELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLL 1126
L K + + ++ + ++ S S + L L +Y++ ++ AD L
Sbjct: 1634 LGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 1693
Query: 1127 ETGQEKMAGDQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 1184
EK QK ++ K E+ + K + M RK++ +
Sbjct: 1694 LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI---- 1749
Query: 1185 QFHTELMAQASAVLKRAH--KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPS-VGL 1241
+EL + +A+ R K + L+ L++ ++ + LE +E+ I V L
Sbjct: 1750 ---SELNHRFAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNL 1799
Query: 1242 VEE--NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 1299
EE N+D D + L + Q + + D+ KR I I L+++ N L +
Sbjct: 1800 KEEDFNKDMNEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDL 1856
Query: 1300 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQ 1354
K + H+ W +Y+ ++ DL+ L + +L + + + +
Sbjct: 1857 RSQRRKKALEISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDR 1909
Query: 1355 ELEMVRDHLNAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATL 1401
EL+ ++ LNA ++ + + + + S Q RL T+
Sbjct: 1910 ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTV 1969
Query: 1402 RSELSRIDSQWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDE 1458
R E + ++ L ++ +P+ + E H Q A+ EV ++ + + E
Sbjct: 1970 REETMMVMTEDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFE 2021
Query: 1459 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAE 1518
D K K I + LQ+ G +IDI + T + LQ S+ VE + E
Sbjct: 2022 DLFKQEESLKNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQE 2068
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH--RIG 1576
L ++ W+ + + ++ + +E W + +++ W E+ L++
Sbjct: 2069 ALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW 2128
Query: 1577 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 1636
+ A + LK+ L+D I ++ V + G +IQ + +SI+ L L W
Sbjct: 2129 EHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQ 2185
Query: 1637 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 1696
+ + K L+ + S + ++ +L EA +++ L G + ++ +++
Sbjct: 2186 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQ 2244
Query: 1697 LQNLQDDLEKQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRWNNLLEEIAEQ 1754
++ L ++L ++ L++ +L P + L N LK+ N++W + + E+
Sbjct: 2245 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEK 2304
Query: 1755 LQSSKALL----QLWQRYKDYSKQCASTVQQQEDRTNEL-LKAATNK----DIADDEVAT 1805
+A + QL ++ +D +Q + N+L + N+ D+ + E+A
Sbjct: 2305 QGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAV 2364
Query: 1806 WIQ--DCNDLL-KGLGTVKDSLFF------LHELGEQLK-----------QQVDAS---- 1841
+ D ++L KG K+ L +L + K +Q D +
Sbjct: 2365 QAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLT 2424
Query: 1842 --AASAIQSDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEE 1897
AS Q+ L ++Q + E A+ K + +SL V F ++ L W+ ++
Sbjct: 2425 TIGASPTQTVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQ 2483
Query: 1898 ILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP--LNDKEIK--- 1952
+++ Q DL I E + + K M P L+ L L +++E +
Sbjct: 2484 VIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII 2542
Query: 1953 --RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGN 2010
R++ + W + R +L L +LE E + L Q KL G
Sbjct: 2543 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2602
Query: 2011 YQHLLEQQRAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQW 2068
Y Q++ E Q RQ + + + +LL DD + ++ ++ W
Sbjct: 2603 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW 2662
Query: 2069 QGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLF 2128
+ + +R +R ++ R Q++ EK WL E + + ++ R L
Sbjct: 2663 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLE 2718
Query: 2129 DEVQFKE--KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKW 2178
D KE K + QG Y E +++L S + +A LQ L + KW
Sbjct: 2719 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2778
Query: 2179 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEE 2230
+ + L W++ + + L L+ +LS+ P +
Sbjct: 2779 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 2838
Query: 2231 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNE 2276
+H R + + V T + ++ L + L A +++ +L +
Sbjct: 2839 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 2898
Query: 2277 RVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDI 2333
+ E + +WE+L + +++I E L E EL L Q E GD+
Sbjct: 2899 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 2958
Query: 2334 LIEEMIEKLK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQ 2391
LI+ + + L+ K + EIA +EN + + +L + + L +N RW+
Sbjct: 2959 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWK 3017
Query: 2392 HLLDLIAARVKKLKE 2406
L + RV++L E
Sbjct: 3018 LLQVAVEDRVRQLHE 3032
Score = 157 bits (397), Expect = 2e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 44 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 101
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 324 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 379
Query: 102 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 160
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 380 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 436
Query: 161 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 219
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 437 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 491
Query: 220 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 279
L ++ V L H + + E + A+ E+++K L
Sbjct: 492 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 533
Query: 280 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 326
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 534 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 593
Query: 327 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 380
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 594 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 645
Query: 381 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 440
L E+S ++IS PS T + + + + Q + P
Sbjct: 646 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 699
Query: 441 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 500
Q + + + +L SW T + + + ++ + D +
Sbjct: 700 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 752
Query: 501 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 560
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 753 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 791
Query: 561 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 620
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 792 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 835
Query: 621 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 680
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 836 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 895
Query: 681 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 740
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 896 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 939
Query: 741 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 788
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 940 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 999
Query: 789 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 819
+ + K +E+ +K S+ E+QM
Sbjct: 1000 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1059
Query: 820 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 875
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 1060 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1119
Query: 876 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 930
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1120 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1179
Query: 931 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 986
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1180 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1236
Query: 987 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 1030
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1237 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1296
Query: 1031 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 1088
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1297 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1340
Query: 1089 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 1148
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1341 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1396
Query: 1149 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 1208
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1397 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1450
Query: 1209 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 1268
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1451 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1509
Query: 1269 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 1325
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1510 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1569
Query: 1326 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 1381
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1570 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1621
Query: 1382 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 1441
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1622 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1681
Query: 1442 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 1501
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1682 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1733
Query: 1502 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 1560
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1734 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1787
Query: 1561 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 1611
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1788 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1847
Query: 1612 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 1666
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1848 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1907
Query: 1667 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 1721
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1908 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1962
Query: 1722 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 1780
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1963 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2011
Query: 1781 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 1840
A D A +D + L +KDSL + + + A
Sbjct: 2012 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2053
Query: 1841 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 1893
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 2054 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2113
Query: 1894 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 1951
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 2114 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2173
Query: 1952 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 2007
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2174 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2230
Query: 2008 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 2064
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2231 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2290
Query: 2065 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 2124
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2291 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2350
Query: 2125 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 2184
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2351 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2408
Query: 2185 LEEQKKKLAFL--------------------------------------------LKDWE 2200
L+E + K L L D+
Sbjct: 2409 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2468
Query: 2201 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 2257
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2469 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2528
Query: 2258 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 2317
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2529 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2585
Query: 2318 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 2373
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2586 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2645
Query: 2374 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 2433
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2646 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2703
Query: 2434 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 2486
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2704 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2762
Query: 2487 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 2546
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2763 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2820
Query: 2547 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 2587
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2821 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2880
Query: 2588 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 2646
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2881 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2936
Query: 2647 WLTEMDLQLTNIE 2659
E+DL+L E
Sbjct: 2937 ---ELDLKLRQAE 2946
Score = 134 bits (337), Expect = 2e-30
Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)
Query: 1854 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 1913
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 311 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 367
Query: 1914 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 1965
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 368 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 427
Query: 1966 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 2023
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 428 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 487
Query: 2024 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 488 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 543
Query: 2080 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 2139
++ + +WQR E WL E D V
Sbjct: 544 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 582
Query: 2140 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 2199
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 583 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 639
Query: 2200 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 2259
+C + LEK ++ AV + LTQ +++
Sbjct: 640 ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 674
Query: 2260 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 2319
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 675 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 719
Query: 2320 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 2371
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 720 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 779
Query: 2372 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 2419
E +E I+ ++N RW L++ R+ L+ ++A +QQL++ +
Sbjct: 780 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 839
Query: 2420 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 2479
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 840 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 890
Query: 2480 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 2539
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 891 EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 947
Query: 2540 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 2599
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 948 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1007
Query: 2600 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 2658
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 1008 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1067
Query: 2659 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 2717
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 1068 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1127
Query: 2718 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 2772
CQ+V+ R E L + + L D ++ + + E+ D +
Sbjct: 1128 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1179
Query: 2773 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 2832
+ L ++ + R++ + A V L+ + S +++A P E
Sbjct: 1180 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1226
Query: 2833 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 2878
+ + + Y L+G LE S + + K L++ F+++ TEN
Sbjct: 1227 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1286
Query: 2879 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 2938
I P G E E S +DS LE+ ++ E++ P + + +
Sbjct: 1287 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1324
Query: 2939 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 2986
GV+D RW L +A+ ++ ++Q++Q Q+ TE+
Sbjct: 1325 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1370
Query: 2987 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 3046
L +Q D Q K+ Q + +K + +L S E + + K+ ++
Sbjct: 1371 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1427
Query: 3047 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 3103
RV S ++ + LQD M+ + F + ++ + E+ +D K + +
Sbjct: 1428 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1480
Query: 3104 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
++ +++ E++Q + + L E + V + Q++ + + E E+V +
Sbjct: 1481 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1540
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 3203
L +V+ ++LEK L +S + L+ W +A +++
Sbjct: 1541 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1585
Score = 108 bits (269), Expect = 1e-22
Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)
Query: 1779 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 1827
++ ED++ + L+++ N D A +EV +W+ D L+ G + + + F
Sbjct: 314 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 373
Query: 1828 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
HE LG +L ++ + +Q L+ L A ++
Sbjct: 374 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 433
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
Q++L ++D + + L+ L W+ + EE + + + +E+LK Q+ +
Sbjct: 434 QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 485
Query: 1928 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 1974
+ DL+ R+N L + + + D+ ++++ L W+ I T +R+
Sbjct: 486 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 545
Query: 1975 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 2034
LQ LL+ Q E+ + +L + E + + ++ Q EM S Q
Sbjct: 546 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 594
Query: 2035 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 2094
L + D LE+ + ++LK LLS + Q+ +D+ R W
Sbjct: 595 LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 645
Query: 2095 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 2152
+ +KL K ++S + + L Q + V +E++ ++ +
Sbjct: 646 LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 701
Query: 2153 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 2212
K+ ++ DS L ++ E+ W + S + + + F + E +D EK
Sbjct: 702 KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 754
Query: 2213 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 2272
+ +++ ++ ++L++A S +L++ ++ ++AD I
Sbjct: 755 VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 794
Query: 2273 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 2332
+E+ L +W E C LS ERLN W + L Q+E + +
Sbjct: 795 QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 843
Query: 2333 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 2383
L I+ + ++ I ++ +L + ++ + +S A + ++
Sbjct: 844 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 903
Query: 2384 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 2441
+ ++ + + AR K+L+ + + + MS++RTW+ E++L+ P +
Sbjct: 904 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 962
Query: 2442 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 2501
+ E ++++L E Q LQ +++ +G L + + A Q ++
Sbjct: 963 DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1018
Query: 2502 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 2556
RW+ + + +E K+EE +K + + W+ E A S
Sbjct: 1019 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 1074
Query: 2557 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 2616
+ K++LK+ + L +N+ +++ E + A L+ + E N +WD++
Sbjct: 1075 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1133
Query: 2617 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 2674
++V + LK + + + + W+T+ + + + E+ + ++Q ++++K
Sbjct: 1134 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1193
Query: 2675 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 2734
++E K++ + +I ++ P+ +++EL+ L Q + R
Sbjct: 1194 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1245
Query: 2735 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 2794
L+ + LE+ A WH+ LLS +N L+ + ++
Sbjct: 1246 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1283
Query: 2795 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 2852
+ P + I D +L R E + R L +G + +
Sbjct: 1284 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1343
Query: 2853 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 2912
L + + K L+ S Q+TE + + +D Y+ + + +
Sbjct: 1344 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1403
Query: 2913 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 2971
+++ L E SL + + V+ + ++ AQ +++ MK L QK F
Sbjct: 1404 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1461
Query: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
L L + + L L+ S + + ++ Q+ L K++ K+ + +
Sbjct: 1462 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1519
Query: 3032 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 3090
+ Q E+ ++L +R++ + ++ + + + E + L+ L + + + L L
Sbjct: 1520 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1579
Query: 3091 ENID---RRKNEIVPIDSNLDAEI 3111
D +++ + + SNLD+E+
Sbjct: 1580 AATDMELTKRSAVEGMPSNLDSEV 1603
Score = 65.9 bits (159), Expect = 7e-10
Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)
Query: 2828 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 2882
PS+ E +DK F + V L +ALE + L A D + Q I +++
Sbjct: 310 PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 369
Query: 2883 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 2935
+ T ++GYM L + ++ +L KL ++EE + +NL ++
Sbjct: 370 QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 421
Query: 2936 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 2995
RWE L+ ++ K+ + + L Q N L + WL TEE +++ L
Sbjct: 422 --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 471
Query: 2996 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 3054
D++ ++ Q+++ K LQ+ ++ + + S+ ++ + + L+++L + R
Sbjct: 472 GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 531
Query: 3055 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 3114
W +C E+ LLQD L++ Q E L + N+I E+L
Sbjct: 532 WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 591
Query: 3115 HHKQLMQIKHELLESQLRVASLQDMSCQLL 3144
K L +K +L + + + L + LL
Sbjct: 592 LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 620
Score = 35.4 bits (80), Expect = 0.95
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 463 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 522
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2902 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2961
Query: 523 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 578
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2962 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3016
Query: 579 STIRMKASGKRQLLEEKLND 598
+++ + + L E D
Sbjct: 3017 KLLQVAVEDRVRQLHEAHRD 3036
>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
Length = 3562
Score = 215 bits (547), Expect = 7e-55
Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)
Query: 1256 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 1315
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 651 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 701
Query: 1316 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 1372
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 702 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 753
Query: 1373 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 1430
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 754 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 812
Query: 1431 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 1487
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 813 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 869
Query: 1488 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 1546
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 870 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 925
Query: 1547 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 1605
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 926 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 985
Query: 1606 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 1665
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 986 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1045
Query: 1666 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 1725
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1046 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1105
Query: 1726 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 1785
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1106 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1165
Query: 1786 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 1845
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1166 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1215
Query: 1846 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 1904
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1216 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1274
Query: 1905 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 1960
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1275 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1334
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 2020
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1335 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1380
Query: 2021 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1381 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1439
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 2136
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1440 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1497
Query: 2137 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 2196
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1498 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1555
Query: 2197 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 2247
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1556 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1610
Query: 2248 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 2307
D L + + IS LN R + + H++ + I L E
Sbjct: 1611 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1661
Query: 2308 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 2367
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1662 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1711
Query: 2368 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 2426
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1712 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1771
Query: 2427 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 2485
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1772 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1819
Query: 2486 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 2527
E IQ L +RWR I + RRL EET + +
Sbjct: 1820 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1874
Query: 2528 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 2581
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1875 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 1930
Query: 2582 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 1931 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 1990
Query: 2642 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 1991 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2049
Query: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 2758
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2050 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2109
Query: 2759 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 2815
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2110 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2168
Query: 2816 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 2862
L+ +SRALP E Q + + ++ L LE Q+ L
Sbjct: 2169 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2224
Query: 2863 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 2905
+ + F +Q+TE +++K P E+ + + + L + S
Sbjct: 2225 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2284
Query: 2906 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 2964
S +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK L M +L
Sbjct: 2285 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2343
Query: 2965 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 3022
+D N W L D L+Q+ + + + D++ I I K K + ++ R+
Sbjct: 2344 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2403
Query: 3023 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 3076
+ + + + ++E+R + DR+ ++ +WD V L+ R +L+D+
Sbjct: 2404 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2463
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
+ E L ++ K +D+ +Q + Q+ +L + Q V
Sbjct: 2464 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2517
Query: 3137 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 3185
D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2518 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2562
Score = 191 bits (486), Expect = 8e-48
Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)
Query: 1122 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 1180
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 273 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 331
Query: 1181 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 1239
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 332 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 391
Query: 1240 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 1285
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 392 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 451
Query: 1286 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 1345
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 452 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 508
Query: 1346 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 1402
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 509 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 568
Query: 1403 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 1459
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 569 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 624
Query: 1460 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 1518
I G + +K + + K + ++S + Q V E +D A
Sbjct: 625 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 682
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 1570
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 683 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 732
Query: 1571 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 1628
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 733 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 792
Query: 1629 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 1688
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 793 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 850
Query: 1689 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 1748
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 851 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 910
Query: 1749 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 1808
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 911 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 966
Query: 1809 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 1865
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 967 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1023
Query: 1866 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 1925
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1024 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1082
Query: 1926 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 1978
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1083 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1142
Query: 1979 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 2036
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1143 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1198
Query: 2037 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 2096
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1199 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1256
Query: 2097 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 2155
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1257 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1303
Query: 2156 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 2212
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1304 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1354
Query: 2213 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 2270
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1355 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1414
Query: 2271 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 2330
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1415 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1474
Query: 2331 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 2384
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1475 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1531
Query: 2385 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 2444
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1532 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1580
Query: 2445 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 2504
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1581 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1622
Query: 2505 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 2563
+ C +E ++ SE F + S I T A L
Sbjct: 1623 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1657
Query: 2564 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 2618
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1658 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1713
Query: 2619 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 2678
R+T + K +++K QQ
Sbjct: 1714 RITD--------------------------------------------ERKREEIKIKQQ 1729
Query: 2679 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 2738
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1730 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1781
Query: 2739 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 2798
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1782 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1837
Query: 2799 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 2858
L + + + + M+ +P E +S S ++
Sbjct: 1838 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 1880
Query: 2859 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
I + +AL +++Q N P+L C+ + + + E L
Sbjct: 1881 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 1915
Query: 2919 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 2958
K ++SL G ++ +HS +T Q+A ++R WE + ++ R
Sbjct: 1916 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 1975
Query: 2959 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 3017
++++KW++F+ D+ WL + E+ L + Q E + K LKELQ +
Sbjct: 1976 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2030
Query: 3018 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 3076
R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2031 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2090
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
F + +L LE D + +P++ + + L++ +Q+ + EL Q + L
Sbjct: 2091 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2147
Query: 3137 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 3183
+ +LV+A E D LE K K + L E+ IK+L +KL
Sbjct: 2148 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2207
Query: 3184 LDVSSSQQDLSSWSS 3198
D+ L W S
Sbjct: 2208 EDLEEQLNHLLLWLS 2222
Score = 187 bits (474), Expect = 2e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 454 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 512
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 294 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 353
Query: 513 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 570
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 354 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 409
Query: 571 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 628
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 410 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 457
Query: 629 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 685
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 458 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 517
Query: 686 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 737
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 518 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 573
Query: 738 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 783
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 574 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 633
Query: 784 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 827
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 634 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 693
Query: 828 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 875
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 694 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 751
Query: 876 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 909
+ L GL E + QS K + + H +Q D
Sbjct: 752 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 811
Query: 910 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 955
+SA TW+ E +L + + E E L + L ++E
Sbjct: 812 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 871
Query: 956 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 1007
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 872 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 924
Query: 1008 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 1066
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 925 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 984
Query: 1067 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 1120
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 985 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1044
Query: 1121 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 1176
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1045 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1103
Query: 1177 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 1230
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1104 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1160
Query: 1231 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 1286
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1161 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1210
Query: 1287 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1211 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1267
Query: 1347 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 1395
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1268 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1327
Query: 1396 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 1438
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1328 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1387
Query: 1439 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 1480
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1388 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1447
Query: 1481 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 1510
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1448 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1507
Query: 1511 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 1557
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1508 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1567
Query: 1558 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 1610
+ W + L + + K Q ED++K + E V+
Sbjct: 1568 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1616
Query: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 1668
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1617 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1676
Query: 1669 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 1722
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1677 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1731
Query: 1723 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 1782
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1732 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1773
Query: 1783 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1774 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1818
Query: 1843 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 1882
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1819 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1878
Query: 1883 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 1940
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 1879 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 1938
Query: 1941 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 1997
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 1939 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 1998
Query: 1998 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 2056
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 1999 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2057
Query: 2057 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 2116
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2058 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2112
Query: 2117 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 2171
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2113 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2172
Query: 2172 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 2228
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2173 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2232
Query: 2229 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 2286
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2233 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2290
Query: 2287 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 2308
L +L ++ + L E A+
Sbjct: 2291 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2350
Query: 2309 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 2362
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2351 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2406
Query: 2363 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 2411
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2407 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2466
Query: 2412 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2467 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2518
Query: 2472 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 2531
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2519 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2574
Query: 2532 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2575 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2629
Query: 2581 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 2639
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2630 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2689
Query: 2640 ARDSILVWLTEMDLQLT 2656
+ +LVWL D +L+
Sbjct: 2690 SLQELLVWLQLKDDELS 2706
Score = 179 bits (453), Expect = 5e-44
Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)
Query: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 537
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 210 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 269
Query: 538 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 597
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 270 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 327
Query: 598 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 655
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 328 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 375
Query: 656 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 700
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 376 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 435
Query: 701 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 760
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 436 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 482
Query: 761 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 819
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 483 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 524
Query: 820 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 879
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 525 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 573
Query: 880 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 936
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 574 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 622
Query: 937 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 986
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 623 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 682
Query: 987 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 1038
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 683 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 738
Query: 1039 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 1094
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 739 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 798
Query: 1095 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 1146
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 799 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 858
Query: 1147 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 1202
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 859 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 918
Query: 1203 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 1262
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 919 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 974
Query: 1263 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 1319
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 975 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1034
Query: 1320 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 1378
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1035 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1092
Query: 1379 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 1438
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1093 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1150
Query: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1151 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1199
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 1558
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1200 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1259
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 1609
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1260 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1317
Query: 1610 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 1666
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1318 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1356
Query: 1667 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 1726
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1357 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1411
Query: 1727 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 1786
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1412 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1468
Query: 1787 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 1843
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1469 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1522
Query: 1844 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 1899
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1523 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1579
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 1953
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1580 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1633
Query: 1954 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 2012
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1634 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1691
Query: 2013 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 2072
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1692 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1739
Query: 2073 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 2132
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1740 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1788
Query: 2133 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 2192
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1789 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1846
Query: 2193 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 2242
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1847 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 1906
Query: 2243 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 2289
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 1907 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 1966
Query: 2290 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 2344
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 1967 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2023
Query: 2345 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 2404
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2024 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2083
Query: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 2464
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2084 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2141
Query: 2465 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 2519
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2142 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2197
Query: 2520 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 2561
+ +L +K D + WL + F I AK+
Sbjct: 2198 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2257
Query: 2562 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 2610
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2258 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2316
Query: 2611 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 2659
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2317 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2376
Query: 2660 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 2718
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2377 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2436
Query: 2719 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 2778
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2437 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2496
Query: 2779 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 2834
+ LA+ LR +W + D++ DL + R ++D
Sbjct: 2497 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2539
Query: 2835 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 2887
++ + +S +ALE R L + LD +F + + T N+++ T
Sbjct: 2540 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2599
Query: 2888 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 2941
L+ S K + L GE + D L+ ++ SL G + + + +
Sbjct: 2600 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2659
Query: 2942 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 3001
+W L+ ++L+ ++ + +W++ + L + WL ++EL + + + D
Sbjct: 2660 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2717
Query: 3002 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 3040
++ Q + ++ + ++ +I+S F E
Sbjct: 2718 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2777
Query: 3041 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 3100
+R L+ + ++N W+++ +W+ + + L + Q E + L L L + K
Sbjct: 2778 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2837
Query: 3101 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 3143
P+ +L + LQDH +++ ++ E+ + V+ + D++ QL
Sbjct: 2838 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2879
Score = 179 bits (453), Expect = 5e-44
Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)
Query: 1323 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 1382
RYQ+ +++ WL SA+D L Q + ++E+V+D + + ++ A +
Sbjct: 220 RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 275
Query: 1383 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 1439
+L G++L+ +L + + ++ +++ ++S+W L Q LH++ MD
Sbjct: 276 ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 333
Query: 1440 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 1499
+ E+ W++ E +K E+ + + +Q++K + D+ +Q+ V+ + V+
Sbjct: 334 LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 392
Query: 1500 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 1559
+ D S EQL + W + ++ LL+ +L W
Sbjct: 393 VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 449
Query: 1560 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 1614
W +E + + H G DQ + ++L+ L+ ++ K++ + K+ +Q+ L+ ++
Sbjct: 450 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 509
Query: 1615 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 1645
NK +S V +T L QT + + +
Sbjct: 510 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 569
Query: 1646 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 1693
+IL+K ++ ++ D +++ + E ++R + S E A+ +
Sbjct: 570 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 629
Query: 1694 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 1742
N +L++ + ER +KF ++ Q++ E +++ +++N
Sbjct: 630 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 687
Query: 1743 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 1799
RW + ++E+L W Y++ + +QQ E T LK
Sbjct: 688 RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 739
Query: 1800 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859
+ + ++ C D + L ++ + L LK++ + +D ++ + H
Sbjct: 740 PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 797
Query: 1860 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 1917
+ + ++ LQ L + +++ A+ W+ ++E L S +D +++R+
Sbjct: 798 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 856
Query: 1918 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 1971
EL+ L L+ E+ + P ++ K + + W +SSQ E
Sbjct: 857 GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 916
Query: 1972 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 2029
KL+ + + + +T +++ + + L E G+ + L +Q + L +++
Sbjct: 917 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 976
Query: 2030 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 2089
+ Q L+S+ GQ++ + + + +L L+ QW + ++ R+ + + +
Sbjct: 977 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1036
Query: 2090 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 2147
++ ++ +W+ E YL P LQ+A +E++ ++ +++ L
Sbjct: 1037 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1093
Query: 2148 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 2207
E+ ++ A A+ AL+ EL + ++ RL + K L + W + +
Sbjct: 1094 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1153
Query: 2208 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
+ + L FK K ++++P EE+ LEN + D+ Q+ +L TL+
Sbjct: 1154 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1210
Query: 2266 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 2325
D++ +NE +E +W EL H+ ++RRQ++ E+ + A +EK+ L
Sbjct: 1211 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1258
Query: 2326 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 2380
I+E + + K IA +K+ QM + K SHE E++
Sbjct: 1259 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1305
Query: 2381 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 2434
K + + Q +L I KKL++ + + K + + L ++ L
Sbjct: 1306 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1364
Query: 2435 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 2494
+ S E +Q +LN L + + + + V V+ ++ +
Sbjct: 1365 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1419
Query: 2495 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 2554
+ L + + A ER+ ++E+ +L +K + + +WL +++ S+
Sbjct: 1420 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1479
Query: 2555 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 2609
+ + E+ +A Q+++ + L+ I + L +E + SL
Sbjct: 1480 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1533
Query: 2610 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 2669
N W + R L L + E F+ D I W+ + D L E +
Sbjct: 1534 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1593
Query: 2670 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 2729
+K+LKA +I K++ Q L+ ++E ++ EL + R++
Sbjct: 1594 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1650
Query: 2730 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 2784
+ L D L E E++ L + ++ D + D+ + + +
Sbjct: 1651 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1710
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 2843
L Q + ER + + + ++ +DL S +AL + Q Y R
Sbjct: 1711 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1761
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 2903
A L +E ++ L + D+ + I++ + ++ K + +G + G
Sbjct: 1762 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1818
Query: 2904 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 2963
+ + +L + +E E F L+ + T V + ++ + + E+ +
Sbjct: 1819 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1876
Query: 2964 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 3023
+ +++ + L + E+ L + D + + Q + LK ++ ++ I
Sbjct: 1877 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 1929
Query: 3024 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 3080
I+ Q+ + R LQ+ LSQ++ +W++V + ++ +G ++ + + FH
Sbjct: 1930 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 1989
Query: 3081 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 3139
++ + L E R+ I N + + + K+L + + Q V +L
Sbjct: 1990 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2042
Query: 3140 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 3198
+++ + TD +EK+ + R + + K++S K LE+ ++ S Q+DL+ +
Sbjct: 2043 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2102
Query: 3199 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 3226
+E D S+ G+ ++K + K
Sbjct: 2103 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2131
Score = 164 bits (415), Expect = 1e-39
Identities = 486/2595 (18%), Positives = 999/2595 (38%), Gaps = 339/2595 (13%)
Query: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
E+ +++QK L K + +GKL L Q + +N+ S + + L+ + +
Sbjct: 472 EMLSSLQKLAVLKADLEKK-KQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWD 529
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
+++ +EK S +Q+ + Q L + T ++ +T+V
Sbjct: 530 NLVQKLEK------------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVT 566
Query: 122 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTS 181
E++ + A+ EEL + + + ++ K+ + ++ +L + + +++A L S
Sbjct: 567 TREQILVKHAQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS 621
Query: 182 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQ 240
PE + S + ++ +E + K + + Q A R + +V + A ++
Sbjct: 622 PEFAIFRKEGNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK 679
Query: 241 EEASRLQHTAIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSN 294
+ + +L I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S
Sbjct: 680 QASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 739
Query: 295 IQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTED 354
+++Q+ ++ ++ G Q QI L K + + +K K +G
Sbjct: 740 PTAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMF 783
Query: 355 LDGELLPTPSAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSP 408
LD + + + V R L L P+ + + + S
Sbjct: 784 LDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQ 843
Query: 409 VANTDASV-NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQ 465
++ TD + Q + QAL + + + + ST+ + + E S ++ +++
Sbjct: 844 LSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 903
Query: 466 RSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ES 522
W+ L + + E + L E + + +K Q+ +Q++ M +++ L E P G S +
Sbjct: 904 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKK 963
Query: 523 QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIR 582
Q+ + + L+ +I +Q +N + +++ +E A+P L++ L L + +
Sbjct: 964 QLKQCRLLVSDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMC 1019
Query: 583 MKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKE 639
+ +++ L+ L + Q+ + + +A+E + T L A+ K
Sbjct: 1020 QQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR 1079
Query: 640 PMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGS 699
+ Q +L E V+A + V E L E + T + + L +L +
Sbjct: 1080 AKEEAQQKEAKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKT 1137
Query: 700 LLELQRALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQ 758
L E+ H+ ++ + E + L T++ PG E
Sbjct: 1138 LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE-------------------- 1177
Query: 759 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ 818
E+ + L ++L+R +I I A+T D G +++++EL +
Sbjct: 1178 -EISEVLDSLENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ET 1223
Query: 819 MRMKWESLHQEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVPT- 869
+W LH+E +QKLL+ ++ QE Q + ++ L+ K D
Sbjct: 1224 FNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQM 1283
Query: 870 -QDKSAVTSLLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---D 920
Q+ + S L + EE+ + G + I + QK VS +
Sbjct: 1284 PQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 1343
Query: 921 VEERLFVATALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLF 964
E+RL + +L E ET QE+ L K + E+ E++
Sbjct: 1344 FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 1403
Query: 965 SQAFPENG-DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 1023
Q + +N +++ + L + L + V +R Q+++ L+ + ++ VL
Sbjct: 1404 RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 1463
Query: 1024 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 1083
LA + ++ A E + + + KE + + LK +V +
Sbjct: 1464 LAATDMELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTV 1518
Query: 1084 LSKLQDMYDELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLL 1126
L K + + ++ + ++ S S + L L +Y++ ++ AD L
Sbjct: 1519 LGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 1578
Query: 1127 ETGQEKMAGDQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 1184
EK QK ++ K E+ + K + M RK++ +
Sbjct: 1579 LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI---- 1634
Query: 1185 QFHTELMAQASAVLKRAH--KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPS-VGL 1241
+EL + +A+ R K + L+ L++ ++ + LE +E+ I V L
Sbjct: 1635 ---SELNHRFAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNL 1684
Query: 1242 VEE--NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 1299
EE N+D D + L + Q + + D+ KR I I L+++ N L +
Sbjct: 1685 KEEDFNKDMNEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDL 1741
Query: 1300 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQ 1354
K + H+ W +Y+ ++ DL+ L + +L + + + +
Sbjct: 1742 RSQRRKKALEISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDR 1794
Query: 1355 ELEMVRDHLNAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATL 1401
EL+ ++ LNA ++ + + + + S Q RL T+
Sbjct: 1795 ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTV 1854
Query: 1402 RSELSRIDSQWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDE 1458
R E + ++ L ++ +P+ + E H Q A+ EV ++ + + E
Sbjct: 1855 REETMMVMTEDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFE 1906
Query: 1459 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAE 1518
D K K I + LQ+ G +IDI + T + LQ S+ VE + E
Sbjct: 1907 DLFKQEESLKNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQE 1953
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH--RIG 1576
L ++ W+ + + ++ + +E W + +++ W E+ L++
Sbjct: 1954 ALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW 2013
Query: 1577 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 1636
+ A + LK+ L+D I ++ V + G +IQ + +SI+ L L W
Sbjct: 2014 EHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQ 2070
Query: 1637 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 1696
+ + K L+ + S + ++ +L EA +++ L G + ++ +++
Sbjct: 2071 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQ 2129
Query: 1697 LQNLQDDLEKQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRWNNLLEEIAEQ 1754
++ L ++L ++ L++ +L P + L N LK+ N++W + + E+
Sbjct: 2130 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEK 2189
Query: 1755 LQSSKALL----QLWQRYKDYSKQCASTVQQQEDRTNEL-LKAATNK----DIADDEVAT 1805
+A + QL ++ +D +Q + N+L + N+ D+ + E+A
Sbjct: 2190 QGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAV 2249
Query: 1806 WIQ--DCNDLL-KGLGTVKDSLFF------LHELGEQLK-----------QQVDAS---- 1841
+ D ++L KG K+ L +L + K +Q D +
Sbjct: 2250 QAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLT 2309
Query: 1842 --AASAIQSDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEE 1897
AS Q+ L ++Q + E A+ K + +SL V F ++ L W+ ++
Sbjct: 2310 TIGASPTQTVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQ 2368
Query: 1898 ILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP--LNDKEIK--- 1952
+++ Q DL I E + + K M P L+ L L +++E +
Sbjct: 2369 VIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII 2427
Query: 1953 --RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGN 2010
R++ + W + R +L L +LE E + L Q KL G
Sbjct: 2428 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2487
Query: 2011 YQHLLEQQRAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQW 2068
Y Q++ E Q RQ + + + +LL DD + ++ ++ W
Sbjct: 2488 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW 2547
Query: 2069 QGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLF 2128
+ + +R +R ++ R Q++ EK WL E + + ++ R L
Sbjct: 2548 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLE 2603
Query: 2129 DEVQFKE--KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKW 2178
D KE K + QG Y E +++L S + +A LQ L + KW
Sbjct: 2604 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2663
Query: 2179 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEE 2230
+ + L W++ + + L L+ +LS+ P +
Sbjct: 2664 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 2723
Query: 2231 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNE 2276
+H R + + V T + ++ L + L A +++ +L +
Sbjct: 2724 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 2783
Query: 2277 RVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDI 2333
+ E + +WE+L + +++I E L E EL L Q E GD+
Sbjct: 2784 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 2843
Query: 2334 LIEEMIEKLK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQ 2391
LI+ + + L+ K + EIA +EN + + +L + + L +N RW+
Sbjct: 2844 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWK 2902
Query: 2392 HLLDLIAARVKKLKE 2406
L + RV++L E
Sbjct: 2903 LLQVAVEDRVRQLHE 2917
Score = 157 bits (397), Expect = 2e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 44 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 101
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 209 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 264
Query: 102 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 160
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 265 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 321
Query: 161 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 219
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 322 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 376
Query: 220 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 279
L ++ V L H + + E + A+ E+++K L
Sbjct: 377 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 418
Query: 280 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 326
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 419 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 478
Query: 327 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 380
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 479 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 530
Query: 381 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 440
L E+S ++IS PS T + + + + Q + P
Sbjct: 531 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 584
Query: 441 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 500
Q + + + +L SW T + + + ++ + D +
Sbjct: 585 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 637
Query: 501 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 560
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 638 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 676
Query: 561 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 620
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 677 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 720
Query: 621 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 680
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 721 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 780
Query: 681 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 740
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 781 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 824
Query: 741 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 788
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 825 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 884
Query: 789 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 819
+ + K +E+ +K S+ E+QM
Sbjct: 885 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 944
Query: 820 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 875
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 945 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1004
Query: 876 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 930
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1005 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1064
Query: 931 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 986
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1065 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1121
Query: 987 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 1030
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1122 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1181
Query: 1031 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 1088
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1182 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1225
Query: 1089 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 1148
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1226 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1281
Query: 1149 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 1208
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1282 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1335
Query: 1209 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 1268
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1336 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1394
Query: 1269 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 1325
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1395 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1454
Query: 1326 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 1381
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1455 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1506
Query: 1382 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 1441
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1507 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1566
Query: 1442 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 1501
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1567 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1618
Query: 1502 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 1560
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1619 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1672
Query: 1561 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 1611
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1673 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1732
Query: 1612 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 1666
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1733 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1792
Query: 1667 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 1721
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1793 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1847
Query: 1722 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 1780
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1848 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 1896
Query: 1781 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 1840
A D A +D + L +KDSL + + + A
Sbjct: 1897 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 1938
Query: 1841 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 1893
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 1939 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 1998
Query: 1894 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 1951
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 1999 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2058
Query: 1952 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 2007
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2059 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2115
Query: 2008 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 2064
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2116 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2175
Query: 2065 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 2124
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2176 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2235
Query: 2125 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 2184
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2236 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2293
Query: 2185 LEEQKKKLAFL--------------------------------------------LKDWE 2200
L+E + K L L D+
Sbjct: 2294 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2353
Query: 2201 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 2257
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2354 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2413
Query: 2258 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 2317
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2414 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2470
Query: 2318 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 2373
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2471 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2530
Query: 2374 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 2433
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2531 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2588
Query: 2434 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 2486
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2589 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2647
Query: 2487 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 2546
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2648 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2705
Query: 2547 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 2587
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2706 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2765
Query: 2588 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 2646
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2766 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2821
Query: 2647 WLTEMDLQLTNIE 2659
E+DL+L E
Sbjct: 2822 ---ELDLKLRQAE 2831
Score = 134 bits (337), Expect = 2e-30
Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)
Query: 1854 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 1913
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 196 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 252
Query: 1914 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 1965
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 253 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 312
Query: 1966 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 2023
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 313 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 372
Query: 2024 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 373 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 428
Query: 2080 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 2139
++ + +WQR E WL E D V
Sbjct: 429 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 467
Query: 2140 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 2199
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 468 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 524
Query: 2200 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 2259
+C + LEK ++ AV + LTQ +++
Sbjct: 525 ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 559
Query: 2260 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 2319
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 560 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 604
Query: 2320 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 2371
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 605 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 664
Query: 2372 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 2419
E +E I+ ++N RW L++ R+ L+ ++A +QQL++ +
Sbjct: 665 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 724
Query: 2420 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 2479
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 725 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 775
Query: 2480 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 2539
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 776 EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 832
Query: 2540 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 2599
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 833 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 892
Query: 2600 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 2658
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 893 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 952
Query: 2659 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 2717
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 953 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1012
Query: 2718 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 2772
CQ+V+ R E L + + L D ++ + + E+ D +
Sbjct: 1013 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1064
Query: 2773 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 2832
+ L ++ + R++ + A V L+ + S +++A P E
Sbjct: 1065 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1111
Query: 2833 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 2878
+ + + Y L+G LE S + + K L++ F+++ TEN
Sbjct: 1112 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1171
Query: 2879 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 2938
I P G E E S +DS LE+ ++ E++ P + + +
Sbjct: 1172 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1209
Query: 2939 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 2986
GV+D RW L +A+ ++ ++Q++Q Q+ TE+
Sbjct: 1210 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1255
Query: 2987 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 3046
L +Q D Q K+ Q + +K + +L S E + + K+ ++
Sbjct: 1256 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1312
Query: 3047 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 3103
RV S ++ + LQD M+ + F + ++ + E+ +D K + +
Sbjct: 1313 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1365
Query: 3104 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
++ +++ E++Q + + L E + V + Q++ + + E E+V +
Sbjct: 1366 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1425
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 3203
L +V+ ++LEK L +S + L+ W +A +++
Sbjct: 1426 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1470
Score = 108 bits (269), Expect = 1e-22
Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)
Query: 1779 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 1827
++ ED++ + L+++ N D A +EV +W+ D L+ G + + + F
Sbjct: 199 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 258
Query: 1828 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
HE LG +L ++ + +Q L+ L A ++
Sbjct: 259 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 318
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
Q++L ++D + + L+ L W+ + EE + + + +E+LK Q+ +
Sbjct: 319 QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 370
Query: 1928 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 1974
+ DL+ R+N L + + + D+ ++++ L W+ I T +R+
Sbjct: 371 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 430
Query: 1975 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 2034
LQ LL+ Q E+ + +L + E + + ++ Q EM S Q
Sbjct: 431 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 479
Query: 2035 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 2094
L + D LE+ + ++LK LLS + Q+ +D+ R W
Sbjct: 480 LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 530
Query: 2095 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 2152
+ +KL K ++S + + L Q + V +E++ ++ +
Sbjct: 531 LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 586
Query: 2153 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 2212
K+ ++ DS L ++ E+ W + S + + + F + E +D EK
Sbjct: 587 KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 639
Query: 2213 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 2272
+ +++ ++ ++L++A S +L++ ++ ++AD I
Sbjct: 640 VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 679
Query: 2273 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 2332
+E+ L +W E C LS ERLN W + L Q+E + +
Sbjct: 680 QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 728
Query: 2333 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 2383
L I+ + ++ I ++ +L + ++ + +S A + ++
Sbjct: 729 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 788
Query: 2384 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 2441
+ ++ + + AR K+L+ + + + MS++RTW+ E++L+ P +
Sbjct: 789 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 847
Query: 2442 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 2501
+ E ++++L E Q LQ +++ +G L + + A Q ++
Sbjct: 848 DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 903
Query: 2502 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 2556
RW+ + + +E K+EE +K + + W+ E A S
Sbjct: 904 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 959
Query: 2557 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 2616
+ K++LK+ + L +N+ +++ E + A L+ + E N +WD++
Sbjct: 960 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1018
Query: 2617 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 2674
++V + LK + + + + W+T+ + + + E+ + ++Q ++++K
Sbjct: 1019 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1078
Query: 2675 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 2734
++E K++ + +I ++ P+ +++EL+ L Q + R
Sbjct: 1079 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1130
Query: 2735 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 2794
L+ + LE+ A WH+ LLS +N L+ + ++
Sbjct: 1131 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1168
Query: 2795 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 2852
+ P + I D +L R E + R L +G + +
Sbjct: 1169 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1228
Query: 2853 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 2912
L + + K L+ S Q+TE + + +D Y+ + + +
Sbjct: 1229 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1288
Query: 2913 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 2971
+++ L E SL + + V+ + ++ AQ +++ MK L QK F
Sbjct: 1289 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1346
Query: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
L L + + L L+ S + + ++ Q+ L K++ K+ + +
Sbjct: 1347 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1404
Query: 3032 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 3090
+ Q E+ ++L +R++ + ++ + + + E + L+ L + + + L L
Sbjct: 1405 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1464
Query: 3091 ENID---RRKNEIVPIDSNLDAEI 3111
D +++ + + SNLD+E+
Sbjct: 1465 AATDMELTKRSAVEGMPSNLDSEV 1488
Score = 65.9 bits (159), Expect = 7e-10
Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)
Query: 2828 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 2882
PS+ E +DK F + V L +ALE + L A D + Q I +++
Sbjct: 195 PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 254
Query: 2883 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 2935
+ T ++GYM L + ++ +L KL ++EE + +NL ++
Sbjct: 255 QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 306
Query: 2936 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 2995
RWE L+ ++ K+ + + L Q N L + WL TEE +++ L
Sbjct: 307 --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 356
Query: 2996 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 3054
D++ ++ Q+++ K LQ+ ++ + + S+ ++ + + L+++L + R
Sbjct: 357 GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 416
Query: 3055 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 3114
W +C E+ LLQD L++ Q E L + N+I E+L
Sbjct: 417 WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 476
Query: 3115 HHKQLMQIKHELLESQLRVASLQDMSCQLL 3144
K L +K +L + + + L + LL
Sbjct: 477 LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 505
Score = 35.4 bits (80), Expect = 0.95
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 463 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 522
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2787 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2846
Query: 523 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 578
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2847 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 2901
Query: 579 STIRMKASGKRQLLEEKLND 598
+++ + + L E D
Sbjct: 2902 KLLQVAVEDRVRQLHEAHRD 2921
>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
Length = 3681
Score = 215 bits (547), Expect = 7e-55
Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)
Query: 1256 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 1315
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 770 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 820
Query: 1316 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 1372
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 821 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 872
Query: 1373 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 1430
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 873 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 931
Query: 1431 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 1487
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 932 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 988
Query: 1488 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 1546
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 989 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1044
Query: 1547 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 1605
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 1045 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1104
Query: 1606 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 1665
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 1105 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1164
Query: 1666 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 1725
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1165 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1224
Query: 1726 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 1785
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1225 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1284
Query: 1786 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 1845
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1285 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1334
Query: 1846 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 1904
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1393
Query: 1905 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 1960
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1394 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1453
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 2020
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1454 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1499
Query: 2021 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1500 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1558
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 2136
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1559 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1616
Query: 2137 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 2196
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1617 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1674
Query: 2197 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 2247
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1675 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1729
Query: 2248 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 2307
D L + + IS LN R + + H++ + I L E
Sbjct: 1730 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1780
Query: 2308 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 2367
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1781 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1830
Query: 2368 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 2426
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1831 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1890
Query: 2427 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 2485
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1891 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1938
Query: 2486 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 2527
E IQ L +RWR I + RRL EET + +
Sbjct: 1939 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1993
Query: 2528 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 2581
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2049
Query: 2582 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 2050 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2109
Query: 2642 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 2110 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2168
Query: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 2758
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2228
Query: 2759 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 2815
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2287
Query: 2816 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 2862
L+ +SRALP E Q + + ++ L LE Q+ L
Sbjct: 2288 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2343
Query: 2863 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 2905
+ + F +Q+TE +++K P E+ + + + L + S
Sbjct: 2344 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2403
Query: 2906 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 2964
S +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK L M +L
Sbjct: 2404 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2462
Query: 2965 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 3022
+D N W L D L+Q+ + + + D++ I I K K + ++ R+
Sbjct: 2463 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2522
Query: 3023 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 3076
+ + + + ++E+R + DR+ ++ +WD V L+ R +L+D+
Sbjct: 2523 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2582
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
+ E L ++ K +D+ +Q + Q+ +L + Q V
Sbjct: 2583 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2636
Query: 3137 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 3185
D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2637 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2681
Score = 191 bits (486), Expect = 8e-48
Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)
Query: 1122 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 1180
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 392 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 450
Query: 1181 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 1239
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 451 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 510
Query: 1240 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 1285
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 511 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570
Query: 1286 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 1345
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 571 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 627
Query: 1346 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 1402
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 628 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687
Query: 1403 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 1459
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 688 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 743
Query: 1460 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 1518
I G + +K + + K + ++S + Q V E +D A
Sbjct: 744 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 1570
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 802 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 851
Query: 1571 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 1628
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 852 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 911
Query: 1629 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 1688
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 912 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 969
Query: 1689 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 1748
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 970 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1029
Query: 1749 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 1808
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 1030 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1085
Query: 1809 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 1865
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 1086 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1142
Query: 1866 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 1925
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1143 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1201
Query: 1926 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 1978
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1202 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1261
Query: 1979 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 2036
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1262 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1317
Query: 2037 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 2096
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1318 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1375
Query: 2097 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 2155
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1376 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1422
Query: 2156 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 2212
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1423 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1473
Query: 2213 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 2270
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1474 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1533
Query: 2271 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 2330
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1534 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1593
Query: 2331 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 2384
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1594 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1650
Query: 2385 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 2444
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1651 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1699
Query: 2445 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 2504
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1700 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1741
Query: 2505 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 2563
+ C +E ++ SE F + S I T A L
Sbjct: 1742 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1776
Query: 2564 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 2618
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1832
Query: 2619 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 2678
R+T + K +++K QQ
Sbjct: 1833 RITD--------------------------------------------ERKREEIKIKQQ 1848
Query: 2679 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 2738
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1849 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1900
Query: 2739 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 2798
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1901 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1956
Query: 2799 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 2858
L + + + + M+ +P E +S S ++
Sbjct: 1957 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 1999
Query: 2859 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
I + +AL +++Q N P+L C+ + + + E L
Sbjct: 2000 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 2034
Query: 2919 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 2958
K ++SL G ++ +HS +T Q+A ++R WE + ++ R
Sbjct: 2035 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2094
Query: 2959 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 3017
++++KW++F+ D+ WL + E+ L + Q E + K LKELQ +
Sbjct: 2095 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2149
Query: 3018 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 3076
R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2150 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2209
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
F + +L LE D + +P++ + + L++ +Q+ + EL Q + L
Sbjct: 2210 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2266
Query: 3137 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 3183
+ +LV+A E D LE K K + L E+ IK+L +KL
Sbjct: 2267 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2326
Query: 3184 LDVSSSQQDLSSWSS 3198
D+ L W S
Sbjct: 2327 EDLEEQLNHLLLWLS 2341
Score = 187 bits (474), Expect = 2e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 454 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 512
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 413 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 472
Query: 513 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 570
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 473 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 528
Query: 571 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 628
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 529 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 576
Query: 629 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 685
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 577 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 636
Query: 686 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 737
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 637 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 692
Query: 738 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 783
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 693 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 752
Query: 784 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 827
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 753 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 812
Query: 828 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 875
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 813 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 870
Query: 876 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 909
+ L GL E + QS K + + H +Q D
Sbjct: 871 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 930
Query: 910 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 955
+SA TW+ E +L + + E E L + L ++E
Sbjct: 931 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 990
Query: 956 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 1007
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 991 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1043
Query: 1008 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 1066
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 1044 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1103
Query: 1067 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 1120
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 1104 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1163
Query: 1121 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 1176
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1164 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1222
Query: 1177 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 1230
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1223 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1279
Query: 1231 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 1286
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1280 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1329
Query: 1287 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1330 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1386
Query: 1347 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 1395
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1387 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1446
Query: 1396 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 1438
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1447 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1506
Query: 1439 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 1480
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1507 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1566
Query: 1481 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 1510
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1567 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1626
Query: 1511 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 1557
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1627 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1686
Query: 1558 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 1610
+ W + L + + K Q ED++K + E V+
Sbjct: 1687 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1735
Query: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 1668
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1736 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1795
Query: 1669 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 1722
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1796 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1850
Query: 1723 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 1782
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1851 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1892
Query: 1783 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1893 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1937
Query: 1843 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 1882
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1997
Query: 1883 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 1940
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 1998 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2057
Query: 1941 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 1997
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 2058 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2117
Query: 1998 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 2056
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 2118 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2176
Query: 2057 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 2116
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2177 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2231
Query: 2117 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 2171
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2232 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2291
Query: 2172 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 2228
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2292 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2351
Query: 2229 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 2286
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2352 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2409
Query: 2287 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 2308
L +L ++ + L E A+
Sbjct: 2410 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2469
Query: 2309 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 2362
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2470 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2525
Query: 2363 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 2411
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2526 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2585
Query: 2412 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2586 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2637
Query: 2472 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 2531
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2638 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2693
Query: 2532 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2694 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2748
Query: 2581 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 2639
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2749 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2808
Query: 2640 ARDSILVWLTEMDLQLT 2656
+ +LVWL D +L+
Sbjct: 2809 SLQELLVWLQLKDDELS 2825
Score = 179 bits (453), Expect = 5e-44
Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)
Query: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 537
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 329 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 388
Query: 538 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 597
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 389 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
Query: 598 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 655
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 447 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 494
Query: 656 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 700
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 495 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 554
Query: 701 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 760
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 555 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 601
Query: 761 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 819
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 602 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 643
Query: 820 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 879
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 644 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 692
Query: 880 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 936
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 693 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 741
Query: 937 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 986
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
Query: 987 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 1038
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 802 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 857
Query: 1039 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 1094
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 858 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917
Query: 1095 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 1146
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
Query: 1147 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 1202
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037
Query: 1203 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 1262
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1093
Query: 1263 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 1319
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 1094 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1153
Query: 1320 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 1378
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1154 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1211
Query: 1379 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 1438
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1212 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1269
Query: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1270 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1318
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 1558
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1319 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1378
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 1609
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1379 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1436
Query: 1610 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 1666
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1437 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1475
Query: 1667 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 1726
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1476 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1530
Query: 1727 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 1786
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1531 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1587
Query: 1787 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 1843
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1588 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1641
Query: 1844 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 1899
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1642 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1698
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 1953
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1699 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1752
Query: 1954 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 2012
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1753 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1810
Query: 2013 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 2072
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1811 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1858
Query: 2073 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 2132
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1859 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1907
Query: 2133 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 2192
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1908 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1965
Query: 2193 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 2242
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1966 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2025
Query: 2243 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 2289
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 2026 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2085
Query: 2290 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 2344
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 2086 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2142
Query: 2345 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 2404
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2143 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2202
Query: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 2464
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2203 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2260
Query: 2465 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 2519
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2261 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2316
Query: 2520 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 2561
+ +L +K D + WL + F I AK+
Sbjct: 2317 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2376
Query: 2562 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 2610
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2435
Query: 2611 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 2659
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2436 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2495
Query: 2660 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 2718
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555
Query: 2719 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 2778
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2556 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2615
Query: 2779 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 2834
+ LA+ LR +W + D++ DL + R ++D
Sbjct: 2616 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2658
Query: 2835 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 2887
++ + +S +ALE R L + LD +F + + T N+++ T
Sbjct: 2659 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2718
Query: 2888 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 2941
L+ S K + L GE + D L+ ++ SL G + + + +
Sbjct: 2719 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2778
Query: 2942 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 3001
+W L+ ++L+ ++ + +W++ + L + WL ++EL + + + D
Sbjct: 2779 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2836
Query: 3002 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 3040
++ Q + ++ + ++ +I+S F E
Sbjct: 2837 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2896
Query: 3041 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 3100
+R L+ + ++N W+++ +W+ + + L + Q E + L L L + K
Sbjct: 2897 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2956
Query: 3101 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 3143
P+ +L + LQDH +++ ++ E+ + V+ + D++ QL
Sbjct: 2957 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2998
Score = 179 bits (453), Expect = 5e-44
Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)
Query: 1323 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 1382
RYQ+ +++ WL SA+D L Q + ++E+V+D + + ++ A +
Sbjct: 339 RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 394
Query: 1383 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 1439
+L G++L+ +L + + ++ +++ ++S+W L Q LH++ MD
Sbjct: 395 ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 452
Query: 1440 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 1499
+ E+ W++ E +K E+ + + +Q++K + D+ +Q+ V+ + V+
Sbjct: 453 LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511
Query: 1500 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 1559
+ D S EQL + W + ++ LL+ +L W
Sbjct: 512 VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
Query: 1560 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 1614
W +E + + H G DQ + ++L+ L+ ++ K++ + K+ +Q+ L+ ++
Sbjct: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 628
Query: 1615 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 1645
NK +S V +T L QT + + +
Sbjct: 629 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 688
Query: 1646 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 1693
+IL+K ++ ++ D +++ + E ++R + S E A+ +
Sbjct: 689 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 748
Query: 1694 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 1742
N +L++ + ER +KF ++ Q++ E +++ +++N
Sbjct: 749 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 806
Query: 1743 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 1799
RW + ++E+L W Y++ + +QQ E T LK
Sbjct: 807 RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 858
Query: 1800 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859
+ + ++ C D + L ++ + L LK++ + +D ++ + H
Sbjct: 859 PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 916
Query: 1860 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 1917
+ + ++ LQ L + +++ A+ W+ ++E L S +D +++R+
Sbjct: 917 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 975
Query: 1918 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 1971
EL+ L L+ E+ + P ++ K + + W +SSQ E
Sbjct: 976 GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 1035
Query: 1972 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 2029
KL+ + + + +T +++ + + L E G+ + L +Q + L +++
Sbjct: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095
Query: 2030 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 2089
+ Q L+S+ GQ++ + + + +L L+ QW + ++ R+ + + +
Sbjct: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
Query: 2090 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 2147
++ ++ +W+ E YL P LQ+A +E++ ++ +++ L
Sbjct: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1212
Query: 2148 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 2207
E+ ++ A A+ AL+ EL + ++ RL + K L + W + +
Sbjct: 1213 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1272
Query: 2208 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
+ + L FK K ++++P EE+ LEN + D+ Q+ +L TL+
Sbjct: 1273 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1329
Query: 2266 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 2325
D++ +NE +E +W EL H+ ++RRQ++ E+ + A +EK+ L
Sbjct: 1330 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1377
Query: 2326 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 2380
I+E + + K IA +K+ QM + K SHE E++
Sbjct: 1378 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1424
Query: 2381 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 2434
K + + Q +L I KKL++ + + K + + L ++ L
Sbjct: 1425 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1483
Query: 2435 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 2494
+ S E +Q +LN L + + + + V V+ ++ +
Sbjct: 1484 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1538
Query: 2495 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 2554
+ L + + A ER+ ++E+ +L +K + + +WL +++ S+
Sbjct: 1539 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1598
Query: 2555 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 2609
+ + E+ +A Q+++ + L+ I + L +E + SL
Sbjct: 1599 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1652
Query: 2610 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 2669
N W + R L L + E F+ D I W+ + D L E +
Sbjct: 1653 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1712
Query: 2670 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 2729
+K+LKA +I K++ Q L+ ++E ++ EL + R++
Sbjct: 1713 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1769
Query: 2730 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 2784
+ L D L E E++ L + ++ D + D+ + + +
Sbjct: 1770 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1829
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 2843
L Q + ER + + + ++ +DL S +AL + Q Y R
Sbjct: 1830 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1880
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 2903
A L +E ++ L + D+ + I++ + ++ K + +G + G
Sbjct: 1881 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1937
Query: 2904 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 2963
+ + +L + +E E F L+ + T V + ++ + + E+ +
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1995
Query: 2964 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 3023
+ +++ + L + E+ L + D + + Q + LK ++ ++ I
Sbjct: 1996 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 2048
Query: 3024 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 3080
I+ Q+ + R LQ+ LSQ++ +W++V + ++ +G ++ + + FH
Sbjct: 2049 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2108
Query: 3081 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 3139
++ + L E R+ I N + + + K+L + + Q V +L
Sbjct: 2109 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2161
Query: 3140 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 3198
+++ + TD +EK+ + R + + K++S K LE+ ++ S Q+DL+ +
Sbjct: 2162 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2221
Query: 3199 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 3226
+E D S+ G+ ++K + K
Sbjct: 2222 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2250
Score = 164 bits (415), Expect = 1e-39
Identities = 486/2595 (18%), Positives = 999/2595 (38%), Gaps = 339/2595 (13%)
Query: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
E+ +++QK L K + +GKL L Q + +N+ S + + L+ + +
Sbjct: 591 EMLSSLQKLAVLKADLEKK-KQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWD 648
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
+++ +EK S +Q+ + Q L + T ++ +T+V
Sbjct: 649 NLVQKLEK------------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVT 685
Query: 122 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTS 181
E++ + A+ EEL + + + ++ K+ + ++ +L + + +++A L S
Sbjct: 686 TREQILVKHAQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS 740
Query: 182 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQ 240
PE + S + ++ +E + K + + Q A R + +V + A ++
Sbjct: 741 PEFAIFRKEGNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK 798
Query: 241 EEASRLQHTAIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSN 294
+ + +L I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S
Sbjct: 799 QASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 858
Query: 295 IQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTED 354
+++Q+ ++ ++ G Q QI L K + + +K K +G
Sbjct: 859 PTAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMF 902
Query: 355 LDGELLPTPSAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSP 408
LD + + + V R L L P+ + + + S
Sbjct: 903 LDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQ 962
Query: 409 VANTDASV-NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQ 465
++ TD + Q + QAL + + + + ST+ + + E S ++ +++
Sbjct: 963 LSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1022
Query: 466 RSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ES 522
W+ L + + E + L E + + +K Q+ +Q++ M +++ L E P G S +
Sbjct: 1023 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKK 1082
Query: 523 QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIR 582
Q+ + + L+ +I +Q +N + +++ +E A+P L++ L L + +
Sbjct: 1083 QLKQCRLLVSDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMC 1138
Query: 583 MKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKE 639
+ +++ L+ L + Q+ + + +A+E + T L A+ K
Sbjct: 1139 QQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR 1198
Query: 640 PMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGS 699
+ Q +L E V+A + V E L E + T + + L +L +
Sbjct: 1199 AKEEAQQKEAKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKT 1256
Query: 700 LLELQRALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQ 758
L E+ H+ ++ + E + L T++ PG E
Sbjct: 1257 LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE-------------------- 1296
Query: 759 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ 818
E+ + L ++L+R +I I A+T D G +++++EL +
Sbjct: 1297 -EISEVLDSLENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ET 1342
Query: 819 MRMKWESLHQEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVPT- 869
+W LH+E +QKLL+ ++ QE Q + ++ L+ K D
Sbjct: 1343 FNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQM 1402
Query: 870 -QDKSAVTSLLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---D 920
Q+ + S L + EE+ + G + I + QK VS +
Sbjct: 1403 PQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 1462
Query: 921 VEERLFVATALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLF 964
E+RL + +L E ET QE+ L K + E+ E++
Sbjct: 1463 FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 1522
Query: 965 SQAFPENG-DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 1023
Q + +N +++ + L + L + V +R Q+++ L+ + ++ VL
Sbjct: 1523 RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 1582
Query: 1024 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 1083
LA + ++ A E + + + KE + + LK +V +
Sbjct: 1583 LAATDMELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTV 1637
Query: 1084 LSKLQDMYDELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLL 1126
L K + + ++ + ++ S S + L L +Y++ ++ AD L
Sbjct: 1638 LGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 1697
Query: 1127 ETGQEKMAGDQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 1184
EK QK ++ K E+ + K + M RK++ +
Sbjct: 1698 LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI---- 1753
Query: 1185 QFHTELMAQASAVLKRAH--KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPS-VGL 1241
+EL + +A+ R K + L+ L++ ++ + LE +E+ I V L
Sbjct: 1754 ---SELNHRFAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNL 1803
Query: 1242 VEE--NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 1299
EE N+D D + L + Q + + D+ KR I I L+++ N L +
Sbjct: 1804 KEEDFNKDMNEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDL 1860
Query: 1300 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQ 1354
K + H+ W +Y+ ++ DL+ L + +L + + + +
Sbjct: 1861 RSQRRKKALEISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDR 1913
Query: 1355 ELEMVRDHLNAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATL 1401
EL+ ++ LNA ++ + + + + S Q RL T+
Sbjct: 1914 ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTV 1973
Query: 1402 RSELSRIDSQWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDE 1458
R E + ++ L ++ +P+ + E H Q A+ EV ++ + + E
Sbjct: 1974 REETMMVMTEDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFE 2025
Query: 1459 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAE 1518
D K K I + LQ+ G +IDI + T + LQ S+ VE + E
Sbjct: 2026 DLFKQEESLKNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQE 2072
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH--RIG 1576
L ++ W+ + + ++ + +E W + +++ W E+ L++
Sbjct: 2073 ALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW 2132
Query: 1577 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 1636
+ A + LK+ L+D I ++ V + G +IQ + +SI+ L L W
Sbjct: 2133 EHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQ 2189
Query: 1637 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 1696
+ + K L+ + S + ++ +L EA +++ L G + ++ +++
Sbjct: 2190 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQ 2248
Query: 1697 LQNLQDDLEKQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRWNNLLEEIAEQ 1754
++ L ++L ++ L++ +L P + L N LK+ N++W + + E+
Sbjct: 2249 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEK 2308
Query: 1755 LQSSKALL----QLWQRYKDYSKQCASTVQQQEDRTNEL-LKAATNK----DIADDEVAT 1805
+A + QL ++ +D +Q + N+L + N+ D+ + E+A
Sbjct: 2309 QGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAV 2368
Query: 1806 WIQ--DCNDLL-KGLGTVKDSLFF------LHELGEQLK-----------QQVDAS---- 1841
+ D ++L KG K+ L +L + K +Q D +
Sbjct: 2369 QAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLT 2428
Query: 1842 --AASAIQSDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEE 1897
AS Q+ L ++Q + E A+ K + +SL V F ++ L W+ ++
Sbjct: 2429 TIGASPTQTVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQ 2487
Query: 1898 ILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP--LNDKEIK--- 1952
+++ Q DL I E + + K M P L+ L L +++E +
Sbjct: 2488 VIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII 2546
Query: 1953 --RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGN 2010
R++ + W + R +L L +LE E + L Q KL G
Sbjct: 2547 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2606
Query: 2011 YQHLLEQQRAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQW 2068
Y Q++ E Q RQ + + + +LL DD + ++ ++ W
Sbjct: 2607 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW 2666
Query: 2069 QGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLF 2128
+ + +R +R ++ R Q++ EK WL E + + ++ R L
Sbjct: 2667 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLE 2722
Query: 2129 DEVQFKE--KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKW 2178
D KE K + QG Y E +++L S + +A LQ L + KW
Sbjct: 2723 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2782
Query: 2179 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEE 2230
+ + L W++ + + L L+ +LS+ P +
Sbjct: 2783 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 2842
Query: 2231 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNE 2276
+H R + + V T + ++ L + L A +++ +L +
Sbjct: 2843 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 2902
Query: 2277 RVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDI 2333
+ E + +WE+L + +++I E L E EL L Q E GD+
Sbjct: 2903 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 2962
Query: 2334 LIEEMIEKLK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQ 2391
LI+ + + L+ K + EIA +EN + + +L + + L +N RW+
Sbjct: 2963 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWK 3021
Query: 2392 HLLDLIAARVKKLKE 2406
L + RV++L E
Sbjct: 3022 LLQVAVEDRVRQLHE 3036
Score = 157 bits (397), Expect = 2e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 44 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 101
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 383
Query: 102 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 160
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 384 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 440
Query: 161 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 219
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 441 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 495
Query: 220 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 279
L ++ V L H + + E + A+ E+++K L
Sbjct: 496 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 537
Query: 280 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 326
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 538 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 597
Query: 327 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 380
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 598 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 649
Query: 381 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 440
L E+S ++IS PS T + + + + Q + P
Sbjct: 650 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 703
Query: 441 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 500
Q + + + +L SW T + + + ++ + D +
Sbjct: 704 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 756
Query: 501 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 560
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 757 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 795
Query: 561 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 620
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 796 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 839
Query: 621 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 680
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 840 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 899
Query: 681 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 740
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 900 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 943
Query: 741 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 788
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 944 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1003
Query: 789 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 819
+ + K +E+ +K S+ E+QM
Sbjct: 1004 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1063
Query: 820 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 875
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 1064 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1123
Query: 876 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 930
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1124 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1183
Query: 931 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 986
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1184 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1240
Query: 987 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 1030
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
Query: 1031 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 1088
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1301 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1344
Query: 1089 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 1148
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1345 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1400
Query: 1149 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 1208
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1401 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1454
Query: 1209 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 1268
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1455 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1513
Query: 1269 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 1325
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1514 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1573
Query: 1326 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 1381
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1574 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1625
Query: 1382 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 1441
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1626 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1685
Query: 1442 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 1501
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1686 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1737
Query: 1502 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 1560
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1738 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1791
Query: 1561 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 1611
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1851
Query: 1612 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 1666
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1852 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1911
Query: 1667 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 1721
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1912 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1966
Query: 1722 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 1780
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2015
Query: 1781 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 1840
A D A +D + L +KDSL + + + A
Sbjct: 2016 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2057
Query: 1841 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 1893
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 2058 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2117
Query: 1894 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 1951
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 2118 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2177
Query: 1952 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 2007
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2178 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2234
Query: 2008 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 2064
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2235 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2294
Query: 2065 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 2124
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2295 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2354
Query: 2125 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 2184
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2355 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2412
Query: 2185 LEEQKKKLAFL--------------------------------------------LKDWE 2200
L+E + K L L D+
Sbjct: 2413 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2472
Query: 2201 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 2257
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2473 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2532
Query: 2258 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 2317
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2533 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2589
Query: 2318 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 2373
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2590 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2649
Query: 2374 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 2433
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2650 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2707
Query: 2434 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 2486
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2766
Query: 2487 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 2546
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2767 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2824
Query: 2547 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 2587
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2825 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2884
Query: 2588 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 2646
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2885 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2940
Query: 2647 WLTEMDLQLTNIE 2659
E+DL+L E
Sbjct: 2941 ---ELDLKLRQAE 2950
Score = 134 bits (337), Expect = 2e-30
Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)
Query: 1854 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 1913
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 315 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 371
Query: 1914 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 1965
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 372 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 431
Query: 1966 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 2023
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 432 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 491
Query: 2024 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 492 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 547
Query: 2080 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 2139
++ + +WQR E WL E D V
Sbjct: 548 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 586
Query: 2140 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 2199
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 587 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 643
Query: 2200 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 2259
+C + LEK ++ AV + LTQ +++
Sbjct: 644 ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 678
Query: 2260 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 2319
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 679 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 723
Query: 2320 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 2371
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 724 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 783
Query: 2372 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 2419
E +E I+ ++N RW L++ R+ L+ ++A +QQL++ +
Sbjct: 784 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 843
Query: 2420 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 2479
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 844 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 894
Query: 2480 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 2539
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 895 EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 951
Query: 2540 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 2599
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 952 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1011
Query: 2600 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 2658
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
Query: 2659 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 2717
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1131
Query: 2718 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 2772
CQ+V+ R E L + + L D ++ + + E+ D +
Sbjct: 1132 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1183
Query: 2773 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 2832
+ L ++ + R++ + A V L+ + S +++A P E
Sbjct: 1184 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1230
Query: 2833 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 2878
+ + + Y L+G LE S + + K L++ F+++ TEN
Sbjct: 1231 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1290
Query: 2879 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 2938
I P G E E S +DS LE+ ++ E++ P + + +
Sbjct: 1291 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1328
Query: 2939 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 2986
GV+D RW L +A+ ++ ++Q++Q Q+ TE+
Sbjct: 1329 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1374
Query: 2987 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 3046
L +Q D Q K+ Q + +K + +L S E + + K+ ++
Sbjct: 1375 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1431
Query: 3047 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 3103
RV S ++ + LQD M+ + F + ++ + E+ +D K + +
Sbjct: 1432 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1484
Query: 3104 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
++ +++ E++Q + + L E + V + Q++ + + E E+V +
Sbjct: 1485 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1544
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 3203
L +V+ ++LEK L +S + L+ W +A +++
Sbjct: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1589
Score = 108 bits (269), Expect = 1e-22
Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)
Query: 1779 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 1827
++ ED++ + L+++ N D A +EV +W+ D L+ G + + + F
Sbjct: 318 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 377
Query: 1828 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
HE LG +L ++ + +Q L+ L A ++
Sbjct: 378 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 437
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
Q++L ++D + + L+ L W+ + EE + + + +E+LK Q+ +
Sbjct: 438 QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 489
Query: 1928 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 1974
+ DL+ R+N L + + + D+ ++++ L W+ I T +R+
Sbjct: 490 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549
Query: 1975 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 2034
LQ LL+ Q E+ + +L + E + + ++ Q EM S Q
Sbjct: 550 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 598
Query: 2035 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 2094
L + D LE+ + ++LK LLS + Q+ +D+ R W
Sbjct: 599 LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 649
Query: 2095 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 2152
+ +KL K ++S + + L Q + V +E++ ++ +
Sbjct: 650 LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 705
Query: 2153 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 2212
K+ ++ DS L ++ E+ W + S + + + F + E +D EK
Sbjct: 706 KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 758
Query: 2213 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 2272
+ +++ ++ ++L++A S +L++ ++ ++AD I
Sbjct: 759 VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 798
Query: 2273 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 2332
+E+ L +W E C LS ERLN W + L Q+E + +
Sbjct: 799 QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 847
Query: 2333 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 2383
L I+ + ++ I ++ +L + ++ + +S A + ++
Sbjct: 848 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 907
Query: 2384 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 2441
+ ++ + + AR K+L+ + + + MS++RTW+ E++L+ P +
Sbjct: 908 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 966
Query: 2442 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 2501
+ E ++++L E Q LQ +++ +G L + + A Q ++
Sbjct: 967 DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1022
Query: 2502 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 2556
RW+ + + +E K+EE +K + + W+ E A S
Sbjct: 1023 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 1078
Query: 2557 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 2616
+ K++LK+ + L +N+ +++ E + A L+ + E N +WD++
Sbjct: 1079 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1137
Query: 2617 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 2674
++V + LK + + + + W+T+ + + + E+ + ++Q ++++K
Sbjct: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1197
Query: 2675 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 2734
++E K++ + +I ++ P+ +++EL+ L Q + R
Sbjct: 1198 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1249
Query: 2735 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 2794
L+ + LE+ A WH+ LLS +N L+ + ++
Sbjct: 1250 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1287
Query: 2795 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 2852
+ P + I D +L R E + R L +G + +
Sbjct: 1288 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1347
Query: 2853 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 2912
L + + K L+ S Q+TE + + +D Y+ + + +
Sbjct: 1348 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1407
Query: 2913 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 2971
+++ L E SL + + V+ + ++ AQ +++ MK L QK F
Sbjct: 1408 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1465
Query: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
L L + + L L+ S + + ++ Q+ L K++ K+ + +
Sbjct: 1466 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1523
Query: 3032 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 3090
+ Q E+ ++L +R++ + ++ + + + E + L+ L + + + L L
Sbjct: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583
Query: 3091 ENID---RRKNEIVPIDSNLDAEI 3111
D +++ + + SNLD+E+
Sbjct: 1584 AATDMELTKRSAVEGMPSNLDSEV 1607
Score = 65.9 bits (159), Expect = 7e-10
Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)
Query: 2828 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 2882
PS+ E +DK F + V L +ALE + L A D + Q I +++
Sbjct: 314 PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 373
Query: 2883 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 2935
+ T ++GYM L + ++ +L KL ++EE + +NL ++
Sbjct: 374 QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 425
Query: 2936 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 2995
RWE L+ ++ K+ + + L Q N L + WL TEE +++ L
Sbjct: 426 --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 475
Query: 2996 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 3054
D++ ++ Q+++ K LQ+ ++ + + S+ ++ + + L+++L + R
Sbjct: 476 GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 535
Query: 3055 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 3114
W +C E+ LLQD L++ Q E L + N+I E+L
Sbjct: 536 WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 595
Query: 3115 HHKQLMQIKHELLESQLRVASLQDMSCQLL 3144
K L +K +L + + + L + LL
Sbjct: 596 LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 624
Score = 35.4 bits (80), Expect = 0.95
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 463 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 522
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2906 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2965
Query: 523 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 578
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2966 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3020
Query: 579 STIRMKASGKRQLLEEKLND 598
+++ + + L E D
Sbjct: 3021 KLLQVAVEDRVRQLHEAHRD 3040
>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
Length = 3562
Score = 215 bits (547), Expect = 7e-55
Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)
Query: 1256 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 1315
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 651 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 701
Query: 1316 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 1372
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 702 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 753
Query: 1373 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 1430
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 754 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 812
Query: 1431 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 1487
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 813 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 869
Query: 1488 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 1546
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 870 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 925
Query: 1547 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 1605
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 926 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 985
Query: 1606 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 1665
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 986 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1045
Query: 1666 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 1725
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1046 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1105
Query: 1726 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 1785
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1106 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1165
Query: 1786 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 1845
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1166 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1215
Query: 1846 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 1904
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1216 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1274
Query: 1905 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 1960
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1275 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1334
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 2020
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1335 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1380
Query: 2021 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1381 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1439
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 2136
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1440 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1497
Query: 2137 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 2196
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1498 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1555
Query: 2197 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 2247
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1556 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1610
Query: 2248 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 2307
D L + + IS LN R + + H++ + I L E
Sbjct: 1611 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1661
Query: 2308 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 2367
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1662 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1711
Query: 2368 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 2426
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1712 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1771
Query: 2427 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 2485
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1772 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1819
Query: 2486 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 2527
E IQ L +RWR I + RRL EET + +
Sbjct: 1820 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1874
Query: 2528 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 2581
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1875 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 1930
Query: 2582 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 1931 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 1990
Query: 2642 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 1991 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2049
Query: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 2758
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2050 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2109
Query: 2759 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 2815
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2110 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2168
Query: 2816 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 2862
L+ +SRALP E Q + + ++ L LE Q+ L
Sbjct: 2169 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2224
Query: 2863 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 2905
+ + F +Q+TE +++K P E+ + + + L + S
Sbjct: 2225 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2284
Query: 2906 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 2964
S +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK L M +L
Sbjct: 2285 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2343
Query: 2965 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 3022
+D N W L D L+Q+ + + + D++ I I K K + ++ R+
Sbjct: 2344 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2403
Query: 3023 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 3076
+ + + + ++E+R + DR+ ++ +WD V L+ R +L+D+
Sbjct: 2404 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2463
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
+ E L ++ K +D+ +Q + Q+ +L + Q V
Sbjct: 2464 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2517
Query: 3137 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 3185
D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2518 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2562
Score = 191 bits (486), Expect = 8e-48
Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)
Query: 1122 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 1180
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 273 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 331
Query: 1181 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 1239
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 332 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 391
Query: 1240 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 1285
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 392 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 451
Query: 1286 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 1345
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 452 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 508
Query: 1346 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 1402
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 509 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 568
Query: 1403 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 1459
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 569 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 624
Query: 1460 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 1518
I G + +K + + K + ++S + Q V E +D A
Sbjct: 625 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 682
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 1570
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 683 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 732
Query: 1571 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 1628
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 733 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 792
Query: 1629 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 1688
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 793 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 850
Query: 1689 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 1748
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 851 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 910
Query: 1749 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 1808
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 911 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 966
Query: 1809 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 1865
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 967 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1023
Query: 1866 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 1925
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1024 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1082
Query: 1926 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 1978
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1083 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1142
Query: 1979 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 2036
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1143 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1198
Query: 2037 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 2096
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1199 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1256
Query: 2097 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 2155
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1257 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1303
Query: 2156 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 2212
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1304 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1354
Query: 2213 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 2270
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1355 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1414
Query: 2271 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 2330
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1415 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1474
Query: 2331 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 2384
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1475 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1531
Query: 2385 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 2444
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1532 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1580
Query: 2445 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 2504
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1581 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1622
Query: 2505 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 2563
+ C +E ++ SE F + S I T A L
Sbjct: 1623 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1657
Query: 2564 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 2618
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1658 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1713
Query: 2619 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 2678
R+T + K +++K QQ
Sbjct: 1714 RITD--------------------------------------------ERKREEIKIKQQ 1729
Query: 2679 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 2738
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1730 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1781
Query: 2739 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 2798
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1782 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1837
Query: 2799 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 2858
L + + + + M+ +P E +S S ++
Sbjct: 1838 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 1880
Query: 2859 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
I + +AL +++Q N P+L C+ + + + E L
Sbjct: 1881 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 1915
Query: 2919 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 2958
K ++SL G ++ +HS +T Q+A ++R WE + ++ R
Sbjct: 1916 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 1975
Query: 2959 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 3017
++++KW++F+ D+ WL + E+ L + Q E + K LKELQ +
Sbjct: 1976 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2030
Query: 3018 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 3076
R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2031 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2090
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
F + +L LE D + +P++ + + L++ +Q+ + EL Q + L
Sbjct: 2091 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2147
Query: 3137 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 3183
+ +LV+A E D LE K K + L E+ IK+L +KL
Sbjct: 2148 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2207
Query: 3184 LDVSSSQQDLSSWSS 3198
D+ L W S
Sbjct: 2208 EDLEEQLNHLLLWLS 2222
Score = 187 bits (474), Expect = 2e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 454 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 512
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 294 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 353
Query: 513 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 570
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 354 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 409
Query: 571 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 628
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 410 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 457
Query: 629 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 685
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 458 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 517
Query: 686 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 737
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 518 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 573
Query: 738 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 783
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 574 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 633
Query: 784 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 827
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 634 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 693
Query: 828 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 875
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 694 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 751
Query: 876 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 909
+ L GL E + QS K + + H +Q D
Sbjct: 752 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 811
Query: 910 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 955
+SA TW+ E +L + + E E L + L ++E
Sbjct: 812 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 871
Query: 956 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 1007
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 872 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 924
Query: 1008 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 1066
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 925 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 984
Query: 1067 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 1120
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 985 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1044
Query: 1121 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 1176
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1045 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1103
Query: 1177 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 1230
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1104 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1160
Query: 1231 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 1286
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1161 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1210
Query: 1287 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1211 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1267
Query: 1347 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 1395
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1268 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1327
Query: 1396 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 1438
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1328 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1387
Query: 1439 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 1480
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1388 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1447
Query: 1481 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 1510
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1448 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1507
Query: 1511 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 1557
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1508 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1567
Query: 1558 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 1610
+ W + L + + K Q ED++K + E V+
Sbjct: 1568 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1616
Query: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 1668
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1617 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1676
Query: 1669 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 1722
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1677 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1731
Query: 1723 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 1782
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1732 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1773
Query: 1783 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1774 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1818
Query: 1843 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 1882
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1819 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1878
Query: 1883 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 1940
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 1879 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 1938
Query: 1941 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 1997
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 1939 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 1998
Query: 1998 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 2056
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 1999 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2057
Query: 2057 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 2116
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2058 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2112
Query: 2117 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 2171
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2113 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2172
Query: 2172 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 2228
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2173 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2232
Query: 2229 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 2286
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2233 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2290
Query: 2287 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 2308
L +L ++ + L E A+
Sbjct: 2291 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2350
Query: 2309 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 2362
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2351 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2406
Query: 2363 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 2411
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2407 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2466
Query: 2412 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2467 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2518
Query: 2472 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 2531
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2519 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2574
Query: 2532 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2575 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2629
Query: 2581 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 2639
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2630 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2689
Query: 2640 ARDSILVWLTEMDLQLT 2656
+ +LVWL D +L+
Sbjct: 2690 SLQELLVWLQLKDDELS 2706
Score = 179 bits (453), Expect = 5e-44
Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)
Query: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 537
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 210 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 269
Query: 538 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 597
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 270 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 327
Query: 598 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 655
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 328 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 375
Query: 656 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 700
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 376 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 435
Query: 701 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 760
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 436 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 482
Query: 761 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 819
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 483 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 524
Query: 820 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 879
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 525 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 573
Query: 880 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 936
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 574 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 622
Query: 937 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 986
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 623 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 682
Query: 987 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 1038
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 683 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 738
Query: 1039 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 1094
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 739 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 798
Query: 1095 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 1146
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 799 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 858
Query: 1147 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 1202
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 859 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 918
Query: 1203 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 1262
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 919 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 974
Query: 1263 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 1319
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 975 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1034
Query: 1320 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 1378
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1035 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1092
Query: 1379 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 1438
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1093 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1150
Query: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1151 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1199
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 1558
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1200 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1259
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 1609
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1260 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1317
Query: 1610 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 1666
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1318 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1356
Query: 1667 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 1726
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1357 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1411
Query: 1727 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 1786
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1412 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1468
Query: 1787 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 1843
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1469 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1522
Query: 1844 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 1899
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1523 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1579
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 1953
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1580 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1633
Query: 1954 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 2012
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1634 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1691
Query: 2013 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 2072
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1692 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1739
Query: 2073 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 2132
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1740 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1788
Query: 2133 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 2192
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1789 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1846
Query: 2193 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 2242
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1847 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 1906
Query: 2243 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 2289
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 1907 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 1966
Query: 2290 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 2344
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 1967 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2023
Query: 2345 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 2404
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2024 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2083
Query: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 2464
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2084 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2141
Query: 2465 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 2519
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2142 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2197
Query: 2520 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 2561
+ +L +K D + WL + F I AK+
Sbjct: 2198 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2257
Query: 2562 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 2610
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2258 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2316
Query: 2611 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 2659
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2317 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2376
Query: 2660 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 2718
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2377 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2436
Query: 2719 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 2778
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2437 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2496
Query: 2779 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 2834
+ LA+ LR +W + D++ DL + R ++D
Sbjct: 2497 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2539
Query: 2835 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 2887
++ + +S +ALE R L + LD +F + + T N+++ T
Sbjct: 2540 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2599
Query: 2888 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 2941
L+ S K + L GE + D L+ ++ SL G + + + +
Sbjct: 2600 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2659
Query: 2942 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 3001
+W L+ ++L+ ++ + +W++ + L + WL ++EL + + + D
Sbjct: 2660 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2717
Query: 3002 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 3040
++ Q + ++ + ++ +I+S F E
Sbjct: 2718 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2777
Query: 3041 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 3100
+R L+ + ++N W+++ +W+ + + L + Q E + L L L + K
Sbjct: 2778 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2837
Query: 3101 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 3143
P+ +L + LQDH +++ ++ E+ + V+ + D++ QL
Sbjct: 2838 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2879
Score = 179 bits (453), Expect = 5e-44
Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)
Query: 1323 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 1382
RYQ+ +++ WL SA+D L Q + ++E+V+D + + ++ A +
Sbjct: 220 RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 275
Query: 1383 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 1439
+L G++L+ +L + + ++ +++ ++S+W L Q LH++ MD
Sbjct: 276 ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 333
Query: 1440 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 1499
+ E+ W++ E +K E+ + + +Q++K + D+ +Q+ V+ + V+
Sbjct: 334 LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 392
Query: 1500 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 1559
+ D S EQL + W + ++ LL+ +L W
Sbjct: 393 VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 449
Query: 1560 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 1614
W +E + + H G DQ + ++L+ L+ ++ K++ + K+ +Q+ L+ ++
Sbjct: 450 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 509
Query: 1615 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 1645
NK +S V +T L QT + + +
Sbjct: 510 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 569
Query: 1646 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 1693
+IL+K ++ ++ D +++ + E ++R + S E A+ +
Sbjct: 570 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 629
Query: 1694 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 1742
N +L++ + ER +KF ++ Q++ E +++ +++N
Sbjct: 630 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 687
Query: 1743 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 1799
RW + ++E+L W Y++ + +QQ E T LK
Sbjct: 688 RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 739
Query: 1800 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859
+ + ++ C D + L ++ + L LK++ + +D ++ + H
Sbjct: 740 PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 797
Query: 1860 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 1917
+ + ++ LQ L + +++ A+ W+ ++E L S +D +++R+
Sbjct: 798 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 856
Query: 1918 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 1971
EL+ L L+ E+ + P ++ K + + W +SSQ E
Sbjct: 857 GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 916
Query: 1972 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 2029
KL+ + + + +T +++ + + L E G+ + L +Q + L +++
Sbjct: 917 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 976
Query: 2030 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 2089
+ Q L+S+ GQ++ + + + +L L+ QW + ++ R+ + + +
Sbjct: 977 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1036
Query: 2090 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 2147
++ ++ +W+ E YL P LQ+A +E++ ++ +++ L
Sbjct: 1037 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1093
Query: 2148 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 2207
E+ ++ A A+ AL+ EL + ++ RL + K L + W + +
Sbjct: 1094 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1153
Query: 2208 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
+ + L FK K ++++P EE+ LEN + D+ Q+ +L TL+
Sbjct: 1154 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1210
Query: 2266 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 2325
D++ +NE +E +W EL H+ ++RRQ++ E+ + A +EK+ L
Sbjct: 1211 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1258
Query: 2326 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 2380
I+E + + K IA +K+ QM + K SHE E++
Sbjct: 1259 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1305
Query: 2381 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 2434
K + + Q +L I KKL++ + + K + + L ++ L
Sbjct: 1306 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1364
Query: 2435 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 2494
+ S E +Q +LN L + + + + V V+ ++ +
Sbjct: 1365 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1419
Query: 2495 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 2554
+ L + + A ER+ ++E+ +L +K + + +WL +++ S+
Sbjct: 1420 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1479
Query: 2555 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 2609
+ + E+ +A Q+++ + L+ I + L +E + SL
Sbjct: 1480 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1533
Query: 2610 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 2669
N W + R L L + E F+ D I W+ + D L E +
Sbjct: 1534 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1593
Query: 2670 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 2729
+K+LKA +I K++ Q L+ ++E ++ EL + R++
Sbjct: 1594 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1650
Query: 2730 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 2784
+ L D L E E++ L + ++ D + D+ + + +
Sbjct: 1651 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1710
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 2843
L Q + ER + + + ++ +DL S +AL + Q Y R
Sbjct: 1711 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1761
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 2903
A L +E ++ L + D+ + I++ + ++ K + +G + G
Sbjct: 1762 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1818
Query: 2904 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 2963
+ + +L + +E E F L+ + T V + ++ + + E+ +
Sbjct: 1819 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1876
Query: 2964 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 3023
+ +++ + L + E+ L + D + + Q + LK ++ ++ I
Sbjct: 1877 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 1929
Query: 3024 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 3080
I+ Q+ + R LQ+ LSQ++ +W++V + ++ +G ++ + + FH
Sbjct: 1930 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 1989
Query: 3081 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 3139
++ + L E R+ I N + + + K+L + + Q V +L
Sbjct: 1990 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2042
Query: 3140 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 3198
+++ + TD +EK+ + R + + K++S K LE+ ++ S Q+DL+ +
Sbjct: 2043 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2102
Query: 3199 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 3226
+E D S+ G+ ++K + K
Sbjct: 2103 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2131
Score = 164 bits (415), Expect = 1e-39
Identities = 486/2595 (18%), Positives = 999/2595 (38%), Gaps = 339/2595 (13%)
Query: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
E+ +++QK L K + +GKL L Q + +N+ S + + L+ + +
Sbjct: 472 EMLSSLQKLAVLKADLEKK-KQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWD 529
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
+++ +EK S +Q+ + Q L + T ++ +T+V
Sbjct: 530 NLVQKLEK------------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVT 566
Query: 122 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTS 181
E++ + A+ EEL + + + ++ K+ + ++ +L + + +++A L S
Sbjct: 567 TREQILVKHAQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS 621
Query: 182 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQ 240
PE + S + ++ +E + K + + Q A R + +V + A ++
Sbjct: 622 PEFAIFRKEGNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK 679
Query: 241 EEASRLQHTAIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSN 294
+ + +L I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S
Sbjct: 680 QASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 739
Query: 295 IQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTED 354
+++Q+ ++ ++ G Q QI L K + + +K K +G
Sbjct: 740 PTAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMF 783
Query: 355 LDGELLPTPSAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSP 408
LD + + + V R L L P+ + + + S
Sbjct: 784 LDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQ 843
Query: 409 VANTDASV-NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQ 465
++ TD + Q + QAL + + + + ST+ + + E S ++ +++
Sbjct: 844 LSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 903
Query: 466 RSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ES 522
W+ L + + E + L E + + +K Q+ +Q++ M +++ L E P G S +
Sbjct: 904 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKK 963
Query: 523 QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIR 582
Q+ + + L+ +I +Q +N + +++ +E A+P L++ L L + +
Sbjct: 964 QLKQCRLLVSDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMC 1019
Query: 583 MKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKE 639
+ +++ L+ L + Q+ + + +A+E + T L A+ K
Sbjct: 1020 QQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR 1079
Query: 640 PMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGS 699
+ Q +L E V+A + V E L E + T + + L +L +
Sbjct: 1080 AKEEAQQKEAKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKT 1137
Query: 700 LLELQRALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQ 758
L E+ H+ ++ + E + L T++ PG E
Sbjct: 1138 LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE-------------------- 1177
Query: 759 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ 818
E+ + L ++L+R +I I A+T D G +++++EL +
Sbjct: 1178 -EISEVLDSLENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ET 1223
Query: 819 MRMKWESLHQEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVPT- 869
+W LH+E +QKLL+ ++ QE Q + ++ L+ K D
Sbjct: 1224 FNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQM 1283
Query: 870 -QDKSAVTSLLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---D 920
Q+ + S L + EE+ + G + I + QK VS +
Sbjct: 1284 PQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 1343
Query: 921 VEERLFVATALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLF 964
E+RL + +L E ET QE+ L K + E+ E++
Sbjct: 1344 FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 1403
Query: 965 SQAFPENG-DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 1023
Q + +N +++ + L + L + V +R Q+++ L+ + ++ VL
Sbjct: 1404 RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 1463
Query: 1024 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 1083
LA + ++ A E + + + KE + + LK +V +
Sbjct: 1464 LAATDMELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTV 1518
Query: 1084 LSKLQDMYDELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLL 1126
L K + + ++ + ++ S S + L L +Y++ ++ AD L
Sbjct: 1519 LGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 1578
Query: 1127 ETGQEKMAGDQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 1184
EK QK ++ K E+ + K + M RK++ +
Sbjct: 1579 LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI---- 1634
Query: 1185 QFHTELMAQASAVLKRAH--KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPS-VGL 1241
+EL + +A+ R K + L+ L++ ++ + LE +E+ I V L
Sbjct: 1635 ---SELNHRFAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNL 1684
Query: 1242 VEE--NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 1299
EE N+D D + L + Q + + D+ KR I I L+++ N L +
Sbjct: 1685 KEEDFNKDMNEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDL 1741
Query: 1300 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQ 1354
K + H+ W +Y+ ++ DL+ L + +L + + + +
Sbjct: 1742 RSQRRKKALEISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDR 1794
Query: 1355 ELEMVRDHLNAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATL 1401
EL+ ++ LNA ++ + + + + S Q RL T+
Sbjct: 1795 ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTV 1854
Query: 1402 RSELSRIDSQWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDE 1458
R E + ++ L ++ +P+ + E H Q A+ EV ++ + + E
Sbjct: 1855 REETMMVMTEDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFE 1906
Query: 1459 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAE 1518
D K K I + LQ+ G +IDI + T + LQ S+ VE + E
Sbjct: 1907 DLFKQEESLKNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQE 1953
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH--RIG 1576
L ++ W+ + + ++ + +E W + +++ W E+ L++
Sbjct: 1954 ALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW 2013
Query: 1577 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 1636
+ A + LK+ L+D I ++ V + G +IQ + +SI+ L L W
Sbjct: 2014 EHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQ 2070
Query: 1637 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 1696
+ + K L+ + S + ++ +L EA +++ L G + ++ +++
Sbjct: 2071 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQ 2129
Query: 1697 LQNLQDDLEKQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRWNNLLEEIAEQ 1754
++ L ++L ++ L++ +L P + L N LK+ N++W + + E+
Sbjct: 2130 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEK 2189
Query: 1755 LQSSKALL----QLWQRYKDYSKQCASTVQQQEDRTNEL-LKAATNK----DIADDEVAT 1805
+A + QL ++ +D +Q + N+L + N+ D+ + E+A
Sbjct: 2190 QGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAV 2249
Query: 1806 WIQ--DCNDLL-KGLGTVKDSLFF------LHELGEQLK-----------QQVDAS---- 1841
+ D ++L KG K+ L +L + K +Q D +
Sbjct: 2250 QAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLT 2309
Query: 1842 --AASAIQSDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEE 1897
AS Q+ L ++Q + E A+ K + +SL V F ++ L W+ ++
Sbjct: 2310 TIGASPTQTVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQ 2368
Query: 1898 ILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP--LNDKEIK--- 1952
+++ Q DL I E + + K M P L+ L L +++E +
Sbjct: 2369 VIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII 2427
Query: 1953 --RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGN 2010
R++ + W + R +L L +LE E + L Q KL G
Sbjct: 2428 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2487
Query: 2011 YQHLLEQQRAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQW 2068
Y Q++ E Q RQ + + + +LL DD + ++ ++ W
Sbjct: 2488 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW 2547
Query: 2069 QGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLF 2128
+ + +R +R ++ R Q++ EK WL E + + ++ R L
Sbjct: 2548 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLE 2603
Query: 2129 DEVQFKE--KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKW 2178
D KE K + QG Y E +++L S + +A LQ L + KW
Sbjct: 2604 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2663
Query: 2179 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEE 2230
+ + L W++ + + L L+ +LS+ P +
Sbjct: 2664 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 2723
Query: 2231 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNE 2276
+H R + + V T + ++ L + L A +++ +L +
Sbjct: 2724 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 2783
Query: 2277 RVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDI 2333
+ E + +WE+L + +++I E L E EL L Q E GD+
Sbjct: 2784 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 2843
Query: 2334 LIEEMIEKLK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQ 2391
LI+ + + L+ K + EIA +EN + + +L + + L +N RW+
Sbjct: 2844 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWK 2902
Query: 2392 HLLDLIAARVKKLKE 2406
L + RV++L E
Sbjct: 2903 LLQVAVEDRVRQLHE 2917
Score = 157 bits (397), Expect = 2e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 44 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 101
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 209 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 264
Query: 102 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 160
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 265 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 321
Query: 161 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 219
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 322 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 376
Query: 220 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 279
L ++ V L H + + E + A+ E+++K L
Sbjct: 377 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 418
Query: 280 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 326
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 419 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 478
Query: 327 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 380
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 479 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 530
Query: 381 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 440
L E+S ++IS PS T + + + + Q + P
Sbjct: 531 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 584
Query: 441 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 500
Q + + + +L SW T + + + ++ + D +
Sbjct: 585 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 637
Query: 501 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 560
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 638 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 676
Query: 561 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 620
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 677 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 720
Query: 621 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 680
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 721 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 780
Query: 681 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 740
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 781 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 824
Query: 741 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 788
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 825 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 884
Query: 789 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 819
+ + K +E+ +K S+ E+QM
Sbjct: 885 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 944
Query: 820 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 875
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 945 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1004
Query: 876 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 930
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1005 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1064
Query: 931 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 986
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1065 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1121
Query: 987 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 1030
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1122 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1181
Query: 1031 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 1088
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1182 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1225
Query: 1089 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 1148
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1226 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1281
Query: 1149 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 1208
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1282 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1335
Query: 1209 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 1268
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1336 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1394
Query: 1269 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 1325
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1395 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1454
Query: 1326 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 1381
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1455 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1506
Query: 1382 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 1441
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1507 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1566
Query: 1442 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 1501
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1567 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1618
Query: 1502 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 1560
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1619 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1672
Query: 1561 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 1611
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1673 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1732
Query: 1612 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 1666
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1733 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1792
Query: 1667 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 1721
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1793 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1847
Query: 1722 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 1780
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1848 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 1896
Query: 1781 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 1840
A D A +D + L +KDSL + + + A
Sbjct: 1897 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 1938
Query: 1841 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 1893
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 1939 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 1998
Query: 1894 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 1951
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 1999 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2058
Query: 1952 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 2007
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2059 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2115
Query: 2008 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 2064
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2116 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2175
Query: 2065 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 2124
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2176 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2235
Query: 2125 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 2184
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2236 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2293
Query: 2185 LEEQKKKLAFL--------------------------------------------LKDWE 2200
L+E + K L L D+
Sbjct: 2294 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2353
Query: 2201 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 2257
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2354 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2413
Query: 2258 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 2317
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2414 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2470
Query: 2318 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 2373
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2471 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2530
Query: 2374 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 2433
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2531 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2588
Query: 2434 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 2486
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2589 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2647
Query: 2487 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 2546
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2648 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2705
Query: 2547 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 2587
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2706 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2765
Query: 2588 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 2646
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2766 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2821
Query: 2647 WLTEMDLQLTNIE 2659
E+DL+L E
Sbjct: 2822 ---ELDLKLRQAE 2831
Score = 134 bits (337), Expect = 2e-30
Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)
Query: 1854 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 1913
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 196 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 252
Query: 1914 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 1965
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 253 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 312
Query: 1966 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 2023
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 313 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 372
Query: 2024 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 373 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 428
Query: 2080 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 2139
++ + +WQR E WL E D V
Sbjct: 429 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 467
Query: 2140 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 2199
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 468 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 524
Query: 2200 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 2259
+C + LEK ++ AV + LTQ +++
Sbjct: 525 ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 559
Query: 2260 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 2319
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 560 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 604
Query: 2320 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 2371
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 605 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 664
Query: 2372 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 2419
E +E I+ ++N RW L++ R+ L+ ++A +QQL++ +
Sbjct: 665 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 724
Query: 2420 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 2479
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 725 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 775
Query: 2480 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 2539
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 776 EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 832
Query: 2540 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 2599
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 833 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 892
Query: 2600 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 2658
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 893 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 952
Query: 2659 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 2717
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 953 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1012
Query: 2718 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 2772
CQ+V+ R E L + + L D ++ + + E+ D +
Sbjct: 1013 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1064
Query: 2773 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 2832
+ L ++ + R++ + A V L+ + S +++A P E
Sbjct: 1065 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1111
Query: 2833 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 2878
+ + + Y L+G LE S + + K L++ F+++ TEN
Sbjct: 1112 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1171
Query: 2879 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 2938
I P G E E S +DS LE+ ++ E++ P + + +
Sbjct: 1172 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1209
Query: 2939 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 2986
GV+D RW L +A+ ++ ++Q++Q Q+ TE+
Sbjct: 1210 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1255
Query: 2987 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 3046
L +Q D Q K+ Q + +K + +L S E + + K+ ++
Sbjct: 1256 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1312
Query: 3047 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 3103
RV S ++ + LQD M+ + F + ++ + E+ +D K + +
Sbjct: 1313 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1365
Query: 3104 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
++ +++ E++Q + + L E + V + Q++ + + E E+V +
Sbjct: 1366 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1425
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 3203
L +V+ ++LEK L +S + L+ W +A +++
Sbjct: 1426 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1470
Score = 108 bits (269), Expect = 1e-22
Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)
Query: 1779 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 1827
++ ED++ + L+++ N D A +EV +W+ D L+ G + + + F
Sbjct: 199 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 258
Query: 1828 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
HE LG +L ++ + +Q L+ L A ++
Sbjct: 259 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 318
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
Q++L ++D + + L+ L W+ + EE + + + +E+LK Q+ +
Sbjct: 319 QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 370
Query: 1928 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 1974
+ DL+ R+N L + + + D+ ++++ L W+ I T +R+
Sbjct: 371 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 430
Query: 1975 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 2034
LQ LL+ Q E+ + +L + E + + ++ Q EM S Q
Sbjct: 431 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 479
Query: 2035 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 2094
L + D LE+ + ++LK LLS + Q+ +D+ R W
Sbjct: 480 LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 530
Query: 2095 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 2152
+ +KL K ++S + + L Q + V +E++ ++ +
Sbjct: 531 LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 586
Query: 2153 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 2212
K+ ++ DS L ++ E+ W + S + + + F + E +D EK
Sbjct: 587 KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 639
Query: 2213 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 2272
+ +++ ++ ++L++A S +L++ ++ ++AD I
Sbjct: 640 VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 679
Query: 2273 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 2332
+E+ L +W E C LS ERLN W + L Q+E + +
Sbjct: 680 QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 728
Query: 2333 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 2383
L I+ + ++ I ++ +L + ++ + +S A + ++
Sbjct: 729 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 788
Query: 2384 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 2441
+ ++ + + AR K+L+ + + + MS++RTW+ E++L+ P +
Sbjct: 789 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 847
Query: 2442 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 2501
+ E ++++L E Q LQ +++ +G L + + A Q ++
Sbjct: 848 DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 903
Query: 2502 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 2556
RW+ + + +E K+EE +K + + W+ E A S
Sbjct: 904 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 959
Query: 2557 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 2616
+ K++LK+ + L +N+ +++ E + A L+ + E N +WD++
Sbjct: 960 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1018
Query: 2617 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 2674
++V + LK + + + + W+T+ + + + E+ + ++Q ++++K
Sbjct: 1019 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1078
Query: 2675 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 2734
++E K++ + +I ++ P+ +++EL+ L Q + R
Sbjct: 1079 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1130
Query: 2735 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 2794
L+ + LE+ A WH+ LLS +N L+ + ++
Sbjct: 1131 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1168
Query: 2795 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 2852
+ P + I D +L R E + R L +G + +
Sbjct: 1169 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1228
Query: 2853 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 2912
L + + K L+ S Q+TE + + +D Y+ + + +
Sbjct: 1229 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1288
Query: 2913 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 2971
+++ L E SL + + V+ + ++ AQ +++ MK L QK F
Sbjct: 1289 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1346
Query: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
L L + + L L+ S + + ++ Q+ L K++ K+ + +
Sbjct: 1347 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1404
Query: 3032 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 3090
+ Q E+ ++L +R++ + ++ + + + E + L+ L + + + L L
Sbjct: 1405 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1464
Query: 3091 ENID---RRKNEIVPIDSNLDAEI 3111
D +++ + + SNLD+E+
Sbjct: 1465 AATDMELTKRSAVEGMPSNLDSEV 1488
Score = 65.9 bits (159), Expect = 7e-10
Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)
Query: 2828 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 2882
PS+ E +DK F + V L +ALE + L A D + Q I +++
Sbjct: 195 PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 254
Query: 2883 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 2935
+ T ++GYM L + ++ +L KL ++EE + +NL ++
Sbjct: 255 QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 306
Query: 2936 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 2995
RWE L+ ++ K+ + + L Q N L + WL TEE +++ L
Sbjct: 307 --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 356
Query: 2996 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 3054
D++ ++ Q+++ K LQ+ ++ + + S+ ++ + + L+++L + R
Sbjct: 357 GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 416
Query: 3055 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 3114
W +C E+ LLQD L++ Q E L + N+I E+L
Sbjct: 417 WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 476
Query: 3115 HHKQLMQIKHELLESQLRVASLQDMSCQLL 3144
K L +K +L + + + L + LL
Sbjct: 477 LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 505
Score = 35.4 bits (80), Expect = 0.95
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 463 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 522
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2787 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2846
Query: 523 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 578
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2847 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 2901
Query: 579 STIRMKASGKRQLLEEKLND 598
+++ + + L E D
Sbjct: 2902 KLLQVAVEDRVRQLHEAHRD 2921
>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
Length = 3685
Score = 215 bits (547), Expect = 7e-55
Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)
Query: 1256 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 1315
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 774 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 824
Query: 1316 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 1372
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 825 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 876
Query: 1373 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 1430
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 877 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 935
Query: 1431 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 1487
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 936 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 992
Query: 1488 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 1546
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 993 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1048
Query: 1547 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 1605
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 1049 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1108
Query: 1606 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 1665
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 1109 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1168
Query: 1666 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 1725
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1169 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1228
Query: 1726 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 1785
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1229 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1288
Query: 1786 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 1845
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1289 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1338
Query: 1846 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 1904
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1397
Query: 1905 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 1960
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1398 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1457
Query: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 2020
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1458 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1503
Query: 2021 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1504 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1562
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 2136
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1563 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1620
Query: 2137 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 2196
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1621 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1678
Query: 2197 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 2247
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1679 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1733
Query: 2248 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 2307
D L + + IS LN R + + H++ + I L E
Sbjct: 1734 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1784
Query: 2308 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 2367
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1785 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1834
Query: 2368 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 2426
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1835 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1894
Query: 2427 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 2485
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1895 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1942
Query: 2486 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 2527
E IQ L +RWR I + RRL EET + +
Sbjct: 1943 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1997
Query: 2528 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 2581
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2053
Query: 2582 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 2054 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2113
Query: 2642 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 2114 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2172
Query: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 2758
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2232
Query: 2759 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 2815
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2291
Query: 2816 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 2862
L+ +SRALP E Q + + ++ L LE Q+ L
Sbjct: 2292 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2347
Query: 2863 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 2905
+ + F +Q+TE +++K P E+ + + + L + S
Sbjct: 2348 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2407
Query: 2906 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 2964
S +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK L M +L
Sbjct: 2408 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2466
Query: 2965 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 3022
+D N W L D L+Q+ + + + D++ I I K K + ++ R+
Sbjct: 2467 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2526
Query: 3023 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 3076
+ + + + ++E+R + DR+ ++ +WD V L+ R +L+D+
Sbjct: 2527 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2586
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
+ E L ++ K +D+ +Q + Q+ +L + Q V
Sbjct: 2587 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2640
Query: 3137 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 3185
D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2641 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2685
Score = 191 bits (486), Expect = 8e-48
Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)
Query: 1122 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 1180
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 396 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 454
Query: 1181 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 1239
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 455 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 514
Query: 1240 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 1285
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 515 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574
Query: 1286 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 1345
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 575 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 631
Query: 1346 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 1402
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 632 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691
Query: 1403 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 1459
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 692 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 747
Query: 1460 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 1518
I G + +K + + K + ++S + Q V E +D A
Sbjct: 748 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 1570
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 806 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 855
Query: 1571 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 1628
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 856 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 915
Query: 1629 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 1688
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 916 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 973
Query: 1689 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 1748
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 974 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1033
Query: 1749 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 1808
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 1034 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1089
Query: 1809 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 1865
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 1090 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1146
Query: 1866 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 1925
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1147 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1205
Query: 1926 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 1978
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1206 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1265
Query: 1979 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 2036
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1266 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1321
Query: 2037 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 2096
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1322 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1379
Query: 2097 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 2155
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1380 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1426
Query: 2156 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 2212
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1427 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1477
Query: 2213 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 2270
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1478 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1537
Query: 2271 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 2330
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1538 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1597
Query: 2331 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 2384
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1598 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1654
Query: 2385 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 2444
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1655 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1703
Query: 2445 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 2504
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1704 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1745
Query: 2505 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 2563
+ C +E ++ SE F + S I T A L
Sbjct: 1746 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1780
Query: 2564 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 2618
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1836
Query: 2619 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 2678
R+T + K +++K QQ
Sbjct: 1837 RITD--------------------------------------------ERKREEIKIKQQ 1852
Query: 2679 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 2738
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1853 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1904
Query: 2739 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 2798
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1905 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1960
Query: 2799 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 2858
L + + + + M+ +P E +S S ++
Sbjct: 1961 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 2003
Query: 2859 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
I + +AL +++Q N P+L C+ + + + E L
Sbjct: 2004 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 2038
Query: 2919 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 2958
K ++SL G ++ +HS +T Q+A ++R WE + ++ R
Sbjct: 2039 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2098
Query: 2959 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 3017
++++KW++F+ D+ WL + E+ L + Q E + K LKELQ +
Sbjct: 2099 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2153
Query: 3018 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 3076
R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2154 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2213
Query: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
F + +L LE D + +P++ + + L++ +Q+ + EL Q + L
Sbjct: 2214 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2270
Query: 3137 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 3183
+ +LV+A E D LE K K + L E+ IK+L +KL
Sbjct: 2271 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2330
Query: 3184 LDVSSSQQDLSSWSS 3198
D+ L W S
Sbjct: 2331 EDLEEQLNHLLLWLS 2345
Score = 187 bits (474), Expect = 2e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 454 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 512
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 417 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 476
Query: 513 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 570
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 477 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 532
Query: 571 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 628
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 533 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 580
Query: 629 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 685
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 581 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 640
Query: 686 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 737
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 641 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 696
Query: 738 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 783
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 697 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 756
Query: 784 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 827
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 757 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 816
Query: 828 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 875
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 817 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 874
Query: 876 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 909
+ L GL E + QS K + + H +Q D
Sbjct: 875 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 934
Query: 910 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 955
+SA TW+ E +L + + E E L + L ++E
Sbjct: 935 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 994
Query: 956 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 1007
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 995 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1047
Query: 1008 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 1066
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 1048 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1107
Query: 1067 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 1120
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 1108 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1167
Query: 1121 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 1176
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1168 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1226
Query: 1177 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 1230
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1227 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1283
Query: 1231 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 1286
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1284 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1333
Query: 1287 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1334 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1390
Query: 1347 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 1395
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1391 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1450
Query: 1396 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 1438
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1451 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1510
Query: 1439 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 1480
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1511 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1570
Query: 1481 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 1510
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1571 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1630
Query: 1511 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 1557
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1631 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1690
Query: 1558 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 1610
+ W + L + + K Q ED++K + E V+
Sbjct: 1691 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1739
Query: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 1668
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1740 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1799
Query: 1669 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 1722
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1800 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1854
Query: 1723 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 1782
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1855 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1896
Query: 1783 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1897 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1941
Query: 1843 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 1882
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 2001
Query: 1883 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 1940
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 2002 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2061
Query: 1941 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 1997
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 2062 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2121
Query: 1998 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 2056
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 2122 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2180
Query: 2057 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 2116
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2181 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2235
Query: 2117 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 2171
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2236 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2295
Query: 2172 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 2228
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2296 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2355
Query: 2229 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 2286
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2356 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2413
Query: 2287 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 2308
L +L ++ + L E A+
Sbjct: 2414 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2473
Query: 2309 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 2362
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2474 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2529
Query: 2363 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 2411
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2530 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2589
Query: 2412 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2590 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2641
Query: 2472 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 2531
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2642 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2697
Query: 2532 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2698 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2752
Query: 2581 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 2639
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2753 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2812
Query: 2640 ARDSILVWLTEMDLQLT 2656
+ +LVWL D +L+
Sbjct: 2813 SLQELLVWLQLKDDELS 2829
Score = 179 bits (453), Expect = 5e-44
Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)
Query: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 537
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 333 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 392
Query: 538 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 597
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 393 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
Query: 598 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 655
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 451 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 498
Query: 656 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 700
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 499 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 558
Query: 701 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 760
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 559 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 605
Query: 761 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 819
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 606 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 647
Query: 820 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 879
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 648 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 696
Query: 880 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 936
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 697 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 745
Query: 937 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 986
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 746 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
Query: 987 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 1038
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 806 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 861
Query: 1039 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 1094
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 862 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 921
Query: 1095 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 1146
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 922 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 981
Query: 1147 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 1202
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 982 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1041
Query: 1203 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 1262
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1097
Query: 1263 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 1319
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 1098 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1157
Query: 1320 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 1378
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1158 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1215
Query: 1379 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 1438
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1216 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1273
Query: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1274 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1322
Query: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 1558
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1323 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1382
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 1609
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1383 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1440
Query: 1610 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 1666
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1441 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1479
Query: 1667 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 1726
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1480 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1534
Query: 1727 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 1786
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1535 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1591
Query: 1787 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 1843
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1592 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1645
Query: 1844 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 1899
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1646 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1702
Query: 1900 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 1953
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1703 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1756
Query: 1954 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 2012
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1757 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1814
Query: 2013 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 2072
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1815 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1862
Query: 2073 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 2132
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1863 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1911
Query: 2133 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 2192
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1912 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1969
Query: 2193 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 2242
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1970 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2029
Query: 2243 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 2289
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 2030 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2089
Query: 2290 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 2344
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 2090 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2146
Query: 2345 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 2404
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2147 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2206
Query: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 2464
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2207 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2264
Query: 2465 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 2519
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2265 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2320
Query: 2520 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 2561
+ +L +K D + WL + F I AK+
Sbjct: 2321 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2380
Query: 2562 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 2610
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2439
Query: 2611 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 2659
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2440 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2499
Query: 2660 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 2718
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2500 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2559
Query: 2719 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 2778
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2560 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2619
Query: 2779 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 2834
+ LA+ LR +W + D++ DL + R ++D
Sbjct: 2620 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2662
Query: 2835 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 2887
++ + +S +ALE R L + LD +F + + T N+++ T
Sbjct: 2663 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2722
Query: 2888 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 2941
L+ S K + L GE + D L+ ++ SL G + + + +
Sbjct: 2723 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2782
Query: 2942 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 3001
+W L+ ++L+ ++ + +W++ + L + WL ++EL + + + D
Sbjct: 2783 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2840
Query: 3002 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 3040
++ Q + ++ + ++ +I+S F E
Sbjct: 2841 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2900
Query: 3041 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 3100
+R L+ + ++N W+++ +W+ + + L + Q E + L L L + K
Sbjct: 2901 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2960
Query: 3101 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 3143
P+ +L + LQDH +++ ++ E+ + V+ + D++ QL
Sbjct: 2961 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 3002
Score = 179 bits (453), Expect = 5e-44
Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)
Query: 1323 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 1382
RYQ+ +++ WL SA+D L Q + ++E+V+D + + ++ A +
Sbjct: 343 RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 398
Query: 1383 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 1439
+L G++L+ +L + + ++ +++ ++S+W L Q LH++ MD
Sbjct: 399 ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 456
Query: 1440 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 1499
+ E+ W++ E +K E+ + + +Q++K + D+ +Q+ V+ + V+
Sbjct: 457 LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515
Query: 1500 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 1559
+ D S EQL + W + ++ LL+ +L W
Sbjct: 516 VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572
Query: 1560 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 1614
W +E + + H G DQ + ++L+ L+ ++ K++ + K+ +Q+ L+ ++
Sbjct: 573 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 632
Query: 1615 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 1645
NK +S V +T L QT + + +
Sbjct: 633 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 692
Query: 1646 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 1693
+IL+K ++ ++ D +++ + E ++R + S E A+ +
Sbjct: 693 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 752
Query: 1694 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 1742
N +L++ + ER +KF ++ Q++ E +++ +++N
Sbjct: 753 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 810
Query: 1743 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 1799
RW + ++E+L W Y++ + +QQ E T LK
Sbjct: 811 RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 862
Query: 1800 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859
+ + ++ C D + L ++ + L LK++ + +D ++ + H
Sbjct: 863 PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 920
Query: 1860 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 1917
+ + ++ LQ L + +++ A+ W+ ++E L S +D +++R+
Sbjct: 921 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 979
Query: 1918 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 1971
EL+ L L+ E+ + P ++ K + + W +SSQ E
Sbjct: 980 GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 1039
Query: 1972 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 2029
KL+ + + + +T +++ + + L E G+ + L +Q + L +++
Sbjct: 1040 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1099
Query: 2030 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 2089
+ Q L+S+ GQ++ + + + +L L+ QW + ++ R+ + + +
Sbjct: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159
Query: 2090 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 2147
++ ++ +W+ E YL P LQ+A +E++ ++ +++ L
Sbjct: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1216
Query: 2148 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 2207
E+ ++ A A+ AL+ EL + ++ RL + K L + W + +
Sbjct: 1217 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1276
Query: 2208 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
+ + L FK K ++++P EE+ LEN + D+ Q+ +L TL+
Sbjct: 1277 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1333
Query: 2266 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 2325
D++ +NE +E +W EL H+ ++RRQ++ E+ + A +EK+ L
Sbjct: 1334 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1381
Query: 2326 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 2380
I+E + + K IA +K+ QM + K SHE E++
Sbjct: 1382 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1428
Query: 2381 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 2434
K + + Q +L I KKL++ + + K + + L ++ L
Sbjct: 1429 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1487
Query: 2435 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 2494
+ S E +Q +LN L + + + + V V+ ++ +
Sbjct: 1488 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1542
Query: 2495 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 2554
+ L + + A ER+ ++E+ +L +K + + +WL +++ S+
Sbjct: 1543 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1602
Query: 2555 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 2609
+ + E+ +A Q+++ + L+ I + L +E + SL
Sbjct: 1603 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1656
Query: 2610 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 2669
N W + R L L + E F+ D I W+ + D L E +
Sbjct: 1657 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1716
Query: 2670 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 2729
+K+LKA +I K++ Q L+ ++E ++ EL + R++
Sbjct: 1717 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1773
Query: 2730 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 2784
+ L D L E E++ L + ++ D + D+ + + +
Sbjct: 1774 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1833
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 2843
L Q + ER + + + ++ +DL S +AL + Q Y R
Sbjct: 1834 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1884
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 2903
A L +E ++ L + D+ + I++ + ++ K + +G + G
Sbjct: 1885 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1941
Query: 2904 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 2963
+ + +L + +E E F L+ + T V + ++ + + E+ +
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1999
Query: 2964 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 3023
+ +++ + L + E+ L + D + + Q + LK ++ ++ I
Sbjct: 2000 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 2052
Query: 3024 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 3080
I+ Q+ + R LQ+ LSQ++ +W++V + ++ +G ++ + + FH
Sbjct: 2053 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2112
Query: 3081 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 3139
++ + L E R+ I N + + + K+L + + Q V +L
Sbjct: 2113 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2165
Query: 3140 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 3198
+++ + TD +EK+ + R + + K++S K LE+ ++ S Q+DL+ +
Sbjct: 2166 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2225
Query: 3199 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 3226
+E D S+ G+ ++K + K
Sbjct: 2226 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2254
Score = 164 bits (415), Expect = 1e-39
Identities = 486/2595 (18%), Positives = 999/2595 (38%), Gaps = 339/2595 (13%)
Query: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
E+ +++QK L K + +GKL L Q + +N+ S + + L+ + +
Sbjct: 595 EMLSSLQKLAVLKADLEKK-KQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWD 652
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
+++ +EK S +Q+ + Q L + T ++ +T+V
Sbjct: 653 NLVQKLEK------------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVT 689
Query: 122 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTS 181
E++ + A+ EEL + + + ++ K+ + ++ +L + + +++A L S
Sbjct: 690 TREQILVKHAQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS 744
Query: 182 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQ 240
PE + S + ++ +E + K + + Q A R + +V + A ++
Sbjct: 745 PEFAIFRKEGNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK 802
Query: 241 EEASRLQHTAIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSN 294
+ + +L I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S
Sbjct: 803 QASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 862
Query: 295 IQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTED 354
+++Q+ ++ ++ G Q QI L K + + +K K +G
Sbjct: 863 PTAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMF 906
Query: 355 LDGELLPTPSAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSP 408
LD + + + V R L L P+ + + + S
Sbjct: 907 LDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQ 966
Query: 409 VANTDASV-NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQ 465
++ TD + Q + QAL + + + + ST+ + + E S ++ +++
Sbjct: 967 LSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1026
Query: 466 RSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ES 522
W+ L + + E + L E + + +K Q+ +Q++ M +++ L E P G S +
Sbjct: 1027 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKK 1086
Query: 523 QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIR 582
Q+ + + L+ +I +Q +N + +++ +E A+P L++ L L + +
Sbjct: 1087 QLKQCRLLVSDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMC 1142
Query: 583 MKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKE 639
+ +++ L+ L + Q+ + + +A+E + T L A+ K
Sbjct: 1143 QQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR 1202
Query: 640 PMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGS 699
+ Q +L E V+A + V E L E + T + + L +L +
Sbjct: 1203 AKEEAQQKEAKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKT 1260
Query: 700 LLELQRALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQ 758
L E+ H+ ++ + E + L T++ PG E
Sbjct: 1261 LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE-------------------- 1300
Query: 759 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ 818
E+ + L ++L+R +I I A+T D G +++++EL +
Sbjct: 1301 -EISEVLDSLENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ET 1346
Query: 819 MRMKWESLHQEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVPT- 869
+W LH+E +QKLL+ ++ QE Q + ++ L+ K D
Sbjct: 1347 FNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQM 1406
Query: 870 -QDKSAVTSLLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---D 920
Q+ + S L + EE+ + G + I + QK VS +
Sbjct: 1407 PQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 1466
Query: 921 VEERLFVATALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLF 964
E+RL + +L E ET QE+ L K + E+ E++
Sbjct: 1467 FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 1526
Query: 965 SQAFPENG-DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 1023
Q + +N +++ + L + L + V +R Q+++ L+ + ++ VL
Sbjct: 1527 RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 1586
Query: 1024 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 1083
LA + ++ A E + + + KE + + LK +V +
Sbjct: 1587 LAATDMELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTV 1641
Query: 1084 LSKLQDMYDELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLL 1126
L K + + ++ + ++ S S + L L +Y++ ++ AD L
Sbjct: 1642 LGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 1701
Query: 1127 ETGQEKMAGDQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 1184
EK QK ++ K E+ + K + M RK++ +
Sbjct: 1702 LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI---- 1757
Query: 1185 QFHTELMAQASAVLKRAH--KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPS-VGL 1241
+EL + +A+ R K + L+ L++ ++ + LE +E+ I V L
Sbjct: 1758 ---SELNHRFAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNL 1807
Query: 1242 VEE--NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 1299
EE N+D D + L + Q + + D+ KR I I L+++ N L +
Sbjct: 1808 KEEDFNKDMNEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDL 1864
Query: 1300 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQ 1354
K + H+ W +Y+ ++ DL+ L + +L + + + +
Sbjct: 1865 RSQRRKKALEISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDR 1917
Query: 1355 ELEMVRDHLNAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATL 1401
EL+ ++ LNA ++ + + + + S Q RL T+
Sbjct: 1918 ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTV 1977
Query: 1402 RSELSRIDSQWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDE 1458
R E + ++ L ++ +P+ + E H Q A+ EV ++ + + E
Sbjct: 1978 REETMMVMTEDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFE 2029
Query: 1459 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAE 1518
D K K I + LQ+ G +IDI + T + LQ S+ VE + E
Sbjct: 2030 DLFKQEESLKNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQE 2076
Query: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH--RIG 1576
L ++ W+ + + ++ + +E W + +++ W E+ L++
Sbjct: 2077 ALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW 2136
Query: 1577 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 1636
+ A + LK+ L+D I ++ V + G +IQ + +SI+ L L W
Sbjct: 2137 EHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQ 2193
Query: 1637 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 1696
+ + K L+ + S + ++ +L EA +++ L G + ++ +++
Sbjct: 2194 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQ 2252
Query: 1697 LQNLQDDLEKQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRWNNLLEEIAEQ 1754
++ L ++L ++ L++ +L P + L N LK+ N++W + + E+
Sbjct: 2253 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEK 2312
Query: 1755 LQSSKALL----QLWQRYKDYSKQCASTVQQQEDRTNEL-LKAATNK----DIADDEVAT 1805
+A + QL ++ +D +Q + N+L + N+ D+ + E+A
Sbjct: 2313 QGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAV 2372
Query: 1806 WIQ--DCNDLL-KGLGTVKDSLFF------LHELGEQLK-----------QQVDAS---- 1841
+ D ++L KG K+ L +L + K +Q D +
Sbjct: 2373 QAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLT 2432
Query: 1842 --AASAIQSDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEE 1897
AS Q+ L ++Q + E A+ K + +SL V F ++ L W+ ++
Sbjct: 2433 TIGASPTQTVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQ 2491
Query: 1898 ILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP--LNDKEIK--- 1952
+++ Q DL I E + + K M P L+ L L +++E +
Sbjct: 2492 VIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII 2550
Query: 1953 --RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGN 2010
R++ + W + R +L L +LE E + L Q KL G
Sbjct: 2551 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2610
Query: 2011 YQHLLEQQRAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQW 2068
Y Q++ E Q RQ + + + +LL DD + ++ ++ W
Sbjct: 2611 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW 2670
Query: 2069 QGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLF 2128
+ + +R +R ++ R Q++ EK WL E + + ++ R L
Sbjct: 2671 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLE 2726
Query: 2129 DEVQFKE--KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKW 2178
D KE K + QG Y E +++L S + +A LQ L + KW
Sbjct: 2727 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2786
Query: 2179 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEE 2230
+ + L W++ + + L L+ +LS+ P +
Sbjct: 2787 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 2846
Query: 2231 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNE 2276
+H R + + V T + ++ L + L A +++ +L +
Sbjct: 2847 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 2906
Query: 2277 RVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDI 2333
+ E + +WE+L + +++I E L E EL L Q E GD+
Sbjct: 2907 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 2966
Query: 2334 LIEEMIEKLK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQ 2391
LI+ + + L+ K + EIA +EN + + +L + + L +N RW+
Sbjct: 2967 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWK 3025
Query: 2392 HLLDLIAARVKKLKE 2406
L + RV++L E
Sbjct: 3026 LLQVAVEDRVRQLHE 3040
Score = 157 bits (397), Expect = 2e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 44 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 101
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 387
Query: 102 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 160
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 388 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 444
Query: 161 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 219
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 445 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 499
Query: 220 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 279
L ++ V L H + + E + A+ E+++K L
Sbjct: 500 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 541
Query: 280 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 326
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 542 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 601
Query: 327 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 380
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 602 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 653
Query: 381 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 440
L E+S ++IS PS T + + + + Q + P
Sbjct: 654 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 707
Query: 441 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 500
Q + + + +L SW T + + + ++ + D +
Sbjct: 708 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 760
Query: 501 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 560
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 761 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 799
Query: 561 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 620
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 800 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 843
Query: 621 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 680
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 844 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 903
Query: 681 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 740
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 904 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 947
Query: 741 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 788
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 948 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1007
Query: 789 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 819
+ + K +E+ +K S+ E+QM
Sbjct: 1008 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1067
Query: 820 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 875
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 1068 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1127
Query: 876 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 930
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1128 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1187
Query: 931 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 986
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1188 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1244
Query: 987 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 1030
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
Query: 1031 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 1088
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1305 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1348
Query: 1089 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 1148
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1349 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1404
Query: 1149 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 1208
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1405 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1458
Query: 1209 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 1268
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1459 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1517
Query: 1269 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 1325
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1518 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1577
Query: 1326 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 1381
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1578 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1629
Query: 1382 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 1441
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1630 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1689
Query: 1442 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 1501
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1690 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1741
Query: 1502 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 1560
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1742 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1795
Query: 1561 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 1611
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1855
Query: 1612 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 1666
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1856 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1915
Query: 1667 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 1721
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1916 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1970
Query: 1722 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 1780
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2019
Query: 1781 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 1840
A D A +D + L +KDSL + + + A
Sbjct: 2020 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2061
Query: 1841 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 1893
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 2062 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2121
Query: 1894 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 1951
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 2122 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2181
Query: 1952 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 2007
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2182 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2238
Query: 2008 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 2064
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2239 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2298
Query: 2065 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 2124
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2299 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2358
Query: 2125 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 2184
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2359 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2416
Query: 2185 LEEQKKKLAFL--------------------------------------------LKDWE 2200
L+E + K L L D+
Sbjct: 2417 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2476
Query: 2201 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 2257
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2477 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2536
Query: 2258 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 2317
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2537 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2593
Query: 2318 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 2373
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2594 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2653
Query: 2374 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 2433
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2654 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2711
Query: 2434 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 2486
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2770
Query: 2487 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 2546
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2771 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2828
Query: 2547 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 2587
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2829 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2888
Query: 2588 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 2646
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2889 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2944
Query: 2647 WLTEMDLQLTNIE 2659
E+DL+L E
Sbjct: 2945 ---ELDLKLRQAE 2954
Score = 134 bits (337), Expect = 2e-30
Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)
Query: 1854 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 1913
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 319 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 375
Query: 1914 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 1965
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 376 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 435
Query: 1966 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 2023
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 436 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495
Query: 2024 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 496 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 551
Query: 2080 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 2139
++ + +WQR E WL E D V
Sbjct: 552 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 590
Query: 2140 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 2199
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 591 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 647
Query: 2200 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 2259
+C + LEK ++ AV + LTQ +++
Sbjct: 648 ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 682
Query: 2260 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 2319
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 683 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 727
Query: 2320 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 2371
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 728 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 787
Query: 2372 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 2419
E +E I+ ++N RW L++ R+ L+ ++A +QQL++ +
Sbjct: 788 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 847
Query: 2420 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 2479
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 848 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 898
Query: 2480 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 2539
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 899 EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 955
Query: 2540 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 2599
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 956 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1015
Query: 2600 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 2658
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
Query: 2659 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 2717
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1135
Query: 2718 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 2772
CQ+V+ R E L + + L D ++ + + E+ D +
Sbjct: 1136 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1187
Query: 2773 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 2832
+ L ++ + R++ + A V L+ + S +++A P E
Sbjct: 1188 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1234
Query: 2833 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 2878
+ + + Y L+G LE S + + K L++ F+++ TEN
Sbjct: 1235 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1294
Query: 2879 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 2938
I P G E E S +DS LE+ ++ E++ P + + +
Sbjct: 1295 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1332
Query: 2939 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 2986
GV+D RW L +A+ ++ ++Q++Q Q+ TE+
Sbjct: 1333 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1378
Query: 2987 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 3046
L +Q D Q K+ Q + +K + +L S E + + K+ ++
Sbjct: 1379 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1435
Query: 3047 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 3103
RV S ++ + LQD M+ + F + ++ + E+ +D K + +
Sbjct: 1436 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1488
Query: 3104 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
++ +++ E++Q + + L E + V + Q++ + + E E+V +
Sbjct: 1489 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1548
Query: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 3203
L +V+ ++LEK L +S + L+ W +A +++
Sbjct: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1593
Score = 108 bits (269), Expect = 1e-22
Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)
Query: 1779 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 1827
++ ED++ + L+++ N D A +EV +W+ D L+ G + + + F
Sbjct: 322 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 381
Query: 1828 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
HE LG +L ++ + +Q L+ L A ++
Sbjct: 382 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 441
Query: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
Q++L ++D + + L+ L W+ + EE + + + +E+LK Q+ +
Sbjct: 442 QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 493
Query: 1928 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 1974
+ DL+ R+N L + + + D+ ++++ L W+ I T +R+
Sbjct: 494 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 553
Query: 1975 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 2034
LQ LL+ Q E+ + +L + E + + ++ Q EM S Q
Sbjct: 554 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 602
Query: 2035 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 2094
L + D LE+ + ++LK LLS + Q+ +D+ R W
Sbjct: 603 LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 653
Query: 2095 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 2152
+ +KL K ++S + + L Q + V +E++ ++ +
Sbjct: 654 LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 709
Query: 2153 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 2212
K+ ++ DS L ++ E+ W + S + + + F + E +D EK
Sbjct: 710 KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 762
Query: 2213 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 2272
+ +++ ++ ++L++A S +L++ ++ ++AD I
Sbjct: 763 VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 802
Query: 2273 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 2332
+E+ L +W E C LS ERLN W + L Q+E + +
Sbjct: 803 QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 851
Query: 2333 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 2383
L I+ + ++ I ++ +L + ++ + +S A + ++
Sbjct: 852 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 911
Query: 2384 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 2441
+ ++ + + AR K+L+ + + + MS++RTW+ E++L+ P +
Sbjct: 912 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 970
Query: 2442 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 2501
+ E ++++L E Q LQ +++ +G L + + A Q ++
Sbjct: 971 DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1026
Query: 2502 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 2556
RW+ + + +E K+EE +K + + W+ E A S
Sbjct: 1027 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 1082
Query: 2557 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 2616
+ K++LK+ + L +N+ +++ E + A L+ + E N +WD++
Sbjct: 1083 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1141
Query: 2617 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 2674
++V + LK + + + + W+T+ + + + E+ + ++Q ++++K
Sbjct: 1142 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1201
Query: 2675 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 2734
++E K++ + +I ++ P+ +++EL+ L Q + R
Sbjct: 1202 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1253
Query: 2735 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 2794
L+ + LE+ A WH+ LLS +N L+ + ++
Sbjct: 1254 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1291
Query: 2795 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 2852
+ P + I D +L R E + R L +G + +
Sbjct: 1292 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1351
Query: 2853 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 2912
L + + K L+ S Q+TE + + +D Y+ + + +
Sbjct: 1352 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1411
Query: 2913 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 2971
+++ L E SL + + V+ + ++ AQ +++ MK L QK F
Sbjct: 1412 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1469
Query: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
L L + + L L+ S + + ++ Q+ L K++ K+ + +
Sbjct: 1470 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1527
Query: 3032 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 3090
+ Q E+ ++L +R++ + ++ + + + E + L+ L + + + L L
Sbjct: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587
Query: 3091 ENID---RRKNEIVPIDSNLDAEI 3111
D +++ + + SNLD+E+
Sbjct: 1588 AATDMELTKRSAVEGMPSNLDSEV 1611
Score = 65.9 bits (159), Expect = 7e-10
Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)
Query: 2828 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 2882
PS+ E +DK F + V L +ALE + L A D + Q I +++
Sbjct: 318 PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 377
Query: 2883 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 2935
+ T ++GYM L + ++ +L KL ++EE + +NL ++
Sbjct: 378 QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 429
Query: 2936 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 2995
RWE L+ ++ K+ + + L Q N L + WL TEE +++ L
Sbjct: 430 --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 479
Query: 2996 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 3054
D++ ++ Q+++ K LQ+ ++ + + S+ ++ + + L+++L + R
Sbjct: 480 GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 539
Query: 3055 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 3114
W +C E+ LLQD L++ Q E L + N+I E+L
Sbjct: 540 WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 599
Query: 3115 HHKQLMQIKHELLESQLRVASLQDMSCQLL 3144
K L +K +L + + + L + LL
Sbjct: 600 LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 628
Score = 35.4 bits (80), Expect = 0.95
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 463 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 522
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2910 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2969
Query: 523 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 578
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2970 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3024
Query: 579 STIRMKASGKRQLLEEKLND 598
+++ + + L E D
Sbjct: 3025 KLLQVAVEDRVRQLHEAHRD 3044
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 170 bits (431), Expect = 2e-41
Identities = 411/2139 (19%), Positives = 855/2139 (39%), Gaps = 251/2139 (11%)
Query: 1047 IEAIQQAEDGLKEFDAGIIELKRRG-----DKLQVEQP--SMQELSKLQDM---YDELMM 1096
++A+ + +GL E D +E K + D+LQ P + Q K +++ ++++
Sbjct: 290 VQALLRKHEGL-ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT 348
Query: 1097 IIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMA---GDQKIIVSSKEEIQQLLDK 1153
+ R + LN + L +R L D DL E A D+ + S + LLD+
Sbjct: 349 LAAERHARLNDSYRL----QRFLADFRDLTSWVTEMKALINADE--LASDVAGAEALLDR 402
Query: 1154 HKEYFQGLESHMILTETLFRKIISF--AVQKETQFHTELMAQASAVLKRAHKRGVELEYI 1211
H+E+ +++H E F+ A+ + ++ + + VL +EL +
Sbjct: 403 HQEHKGEIDAH----EDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWEL 458
Query: 1212 LETWSHLDEDQQELSRQLEVVES--SIPSVGLVEENEDRLIDRITL----YQHLKSSLNE 1265
D Q R E V++ S L+ E+ +D + ++ + SL+
Sbjct: 459 RRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSA 518
Query: 1266 YQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILK---HWT 1322
+ K+ LD+ LI + +E + + LS N + + R L H
Sbjct: 519 QEEKI-TALDEFATKLIQNNHYAMEDVATRR-DALLSRRNALHERAMRRRAQLADSFHLQ 576
Query: 1323 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE-MVRDHLNAFLEFSKEVDAQSSLKS 1381
++ +S +L W+ ++++ T ++ P L+ V+ H F E+ A S
Sbjct: 577 QFFRDSDELKSWVN---EKMKTATDEAYKDPSNLQGKVQKHQ----AFEAELSANQSRID 629
Query: 1382 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 1441
++ G +L+ + + + ++ + S W LL KL + + +R+ +
Sbjct: 630 ALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN-VE 688
Query: 1442 EVMSWISLMENVIQKDE--DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 1499
++ W+ +E + D+ ++ N + +K+ + D+ Q +D +
Sbjct: 689 DIELWLYEVEGHLASDDYGKDLTN------VQNLQKKHALLEADVAAHQDRIDGITIQAR 742
Query: 1500 QISSQDVESKRSDKTDFAEQLGAMNKSWQIL-QGLVTEKIQLLEGLLESWSEYENNVQCL 1558
Q ++ D + ++ A+ ++ L + +V K +L + L + +V+
Sbjct: 743 QFQ----DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL--RLQQLFRDVEDE 796
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKE 1618
+TW +E +R D VQN LK Q L+ I E ++ + Q G A+++ +
Sbjct: 797 ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGH 855
Query: 1619 DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 1678
+ V + L EL Q W L Q + L+ L Q + ++ S++ E
Sbjct: 856 FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESWMREK----- 909
Query: 1679 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE---CHPPVTETLTN 1735
+ GS + + + D+ + L E L +GS L ++ C V T
Sbjct: 910 --EPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDE 966
Query: 1736 TLKEVNMRWNNLLEEIAEQLQSSKA--LLQLWQRYKDYSKQCASTVQ------------- 1780
T KE+ + + E+ ++ K L L KD+ K + Q
Sbjct: 967 TGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDP 1026
Query: 1781 ----QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 1836
+E+ E A ++ D++ ++ + + V++ L ELGE+ K
Sbjct: 1027 AQSASRENLLEEQGSIALRQEQIDNQTRI-TKEAGSVSLRMKQVEELYHSLLELGEKRKG 1085
Query: 1837 QVDASAAS-AIQSDQLSLSQHLCALEQALCKQQTSL---QAGVLD--YETFAKSLEALEA 1890
++ S + + L Q + E AL ++ Q VL ++ F K L+A E+
Sbjct: 1086 MLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANES 1145
Query: 1891 WIVEAEEILQGQDPS--HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLND 1948
+ + ++ + + + ++ +Q+ +E+ G M + + + RL ++
Sbjct: 1146 RLKDINKVAEDLESEGLMAEEVQAVQQ--QEVYGMMPRDETDSKTASPWKSA--RLMVHT 1201
Query: 1949 -KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 2007
++ LN W + ER S+L + Q F + E++ + Q L +
Sbjct: 1202 VATFNSIKELNERWRSLQQLAEER-SQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD- 1259
Query: 2008 SGNYQHLLEQ----QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTL 2063
NY H L QR HE F+ ++ + ++S+ +RL+ Q + ++ K T
Sbjct: 1260 --NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTE 1316
Query: 2064 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 2123
L+ W + +RA QR+ + QR+ L W+ + L S + +
Sbjct: 1317 LNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIRGLVSS--DELAKDVTG 1373
Query: 2124 ARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA------ALQAELAEIQEK 2177
A L + Q + G++ + G+QLL + L E A++++
Sbjct: 1374 AEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKA 1433
Query: 2178 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMR 2237
W M L +Q +L +D E+ E +A L T K D + + A +
Sbjct: 1434 WVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK------GDSLDSVEALIKK 1486
Query: 2238 CKELENAVGSWTDDLTQLSLLKDTLSA--YISADDISILNERVELLQRQWEELCHQLSLR 2295
++ + A+ + + L D L A + + DIS + R E+L R W L Q+ +
Sbjct: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDIS--SRRNEVLDR-WRRLKAQMIEK 1543
Query: 2296 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG-----DILIEEMIEKLKKDYQEEI 2350
R ++GE FS E+ W+++ S +I + +++ K +K E
Sbjct: 1544 RSKLGES-QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEA 1602
Query: 2351 AI-AQENKIQ-LQQMGERL-AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET 2407
+ A ++I+ + MG L + + ++ +L + D+WQ L+ A + +KLKE
Sbjct: 1603 ELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA 1662
Query: 2408 LVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGV 2467
Q + + WL+ +E+ LA S + L + Q L+ DI H +
Sbjct: 1663 -NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLAS--VNNLLKKHQLLEADISAHEDRL 1719
Query: 2468 ASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQK 2527
+ + + L+ ++ + ++ ++ R++ I +M+ RR K+ E+ RL Q
Sbjct: 1720 KDLNSQADSLM-----TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ- 1773
Query: 2528 FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQY 2587
F D E W+K ++ G T + KK + + ++ ++ +
Sbjct: 1774 FFRDMDDEESWIK-EKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTG 1832
Query: 2588 RRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVW 2647
++L+ +N T ++Q + + + W L++ + +RL+ + + ++F + W
Sbjct: 1833 KKLSDDN-TIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESL-EYQQFVANVEEEEAW 1890
Query: 2648 LTEMDLQLTNIEHFSE--CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 2705
+ E + L E + + +Q +K+ +AF+ + +++ +++ + G+ LI+K+
Sbjct: 1891 INE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKN---- 1945
Query: 2706 AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 2765
+ + + +++ + K + D E + R+ +L++++A +W
Sbjct: 1946 -----------NHHEENISSKMKGLNGK-----VSDLEKAAAQRKAKLDENSAFLQFNWK 1989
Query: 2766 DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR 2825
+S + + +S L+++ GRD + + + D L + ++
Sbjct: 1990 ADVVESWIGEKENS---------LKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2040
Query: 2826 ALPSEDE----EGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 2881
+D+ + K R A L S L + K L +++ ++ E++
Sbjct: 2041 ITALKDQLLAAKHVQSKAIEARHA-SLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFL 2099
Query: 2882 SKTPTGPELDTSYKG---------------YMKLLGEC----SSSIDSVKRLEHKLKEEE 2922
+ ++ ++ +K L E SS+ S + ++L E +
Sbjct: 2100 TFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELD 2159
Query: 2923 ESLPGF---VNLHSTETQTAGVIDRWELLQAQALSKEL-------RMKQNLQKWQQFNSD 2972
+ F N ++ T A + + W LQ +EL R ++N + Q+F
Sbjct: 2160 RQIKSFRVASNPYTWFTMEA-LEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQH 2218
Query: 2973 LNSIWAWLGDT-----------------EEELEQLQRLELSTDIQTIELQIKKLKELQKA 3015
N+ W+ +T E +LE +R +I+ + Q+KK+++L A
Sbjct: 2219 ANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKH--QEIRAMRSQLKKIEDLGAA 2276
Query: 3016 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGR 3054
++ +A+IL ++T+ + D+L Q+ R
Sbjct: 2277 ME--EALIL-----DNKYTEHSTVGLAQQWDQLDQLGMR 2308
Score = 165 bits (418), Expect = 6e-40
Identities = 365/1871 (19%), Positives = 736/1871 (39%), Gaps = 253/1871 (13%)
Query: 1324 YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV 1383
+Q ++ +L W+Q ++L+ + ++ P L+ L F EV A S +
Sbjct: 49 FQRDAEELEKWIQ---EKLQIASDENYKDPTNLQ---GKLQKHQAFEAEVQANSGAIVKL 102
Query: 1384 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPS-RHAISE 1442
TGN ++ + T+R+ L + QW LL + KL LQ KL +
Sbjct: 103 DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKL--LQAQKLVQYLRECED 160
Query: 1443 VMSWISLMENVIQKDEDNIKNSIGYKAIH-EYLQ-KYKGFKIDINCKQLTVDFVNQSVLQ 1500
VM WI+ E ++ +E +G H E LQ K++ F+ D+ + V+ VNQ +
Sbjct: 161 VMDWINDKEAIVTSEE------LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAK 214
Query: 1501 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 1560
+ + + KT E +N +WQ L+GL ++ L G E + +V +
Sbjct: 215 LIQEQHPEEELIKTKQDE----VNAAWQRLKGLALQRQGKLFGAAEV-QRFNRDVDETIS 269
Query: 1561 WFETQEKRLKQQHRIGDQASVQNAL-------KDCQDLEDLIKAKEKEVEKIEQN---GL 1610
W + +E+ + D ASVQ L +D LED +KA E ++++Q+
Sbjct: 270 WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSA 329
Query: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL 1670
IQ K+E EL W + + + L + F + S++
Sbjct: 330 TQIQVKRE-----------ELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWV 377
Query: 1671 MEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVT 1730
E + +L L + + +D Q + +++ E S + LL H
Sbjct: 378 TEMK-ALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH---- 432
Query: 1731 ETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAS------TVQQQED 1784
EV + L EE A ALL+LW+ + +QC +Q ++
Sbjct: 433 ----YASDEVREKLTVLSEERA-------ALLELWELRRQQYEQCMDLQLFYRDTEQVDN 481
Query: 1785 RTNELLKAATNKDIAD--DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
++ N+D+ D D V ++ D K L ++ + L E +L Q + A
Sbjct: 482 WMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN-NHYA 540
Query: 1843 ASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
+ + + +L AL + +++ L A + F + + L++W+ E++
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQL-ADSFHLQQFFRDSDELKSWV--NEKMKTAT 597
Query: 1903 DPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-----PLNDKEIKRMQNL 1957
D ++ D S +Q ++++ + + S+ +D L + G +L D+ RM +
Sbjct: 598 DEAY-KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEV 656
Query: 1958 NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG----NYQH 2013
W + T + KL+ Q Q F E +L + E LA + G N Q+
Sbjct: 657 ISLWKKLLEATELKGIKLRE-ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQN 715
Query: 2014 LLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIR 2073
L Q+ H L +A++ + Q + I I ++ + G D + K L +++ +
Sbjct: 716 L---QKKHALLEADVAAHQDRIDGITIQARQFQDAGHF-DAENIKKKQEALVARYEALKE 771
Query: 2074 RAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQF 2133
R+ + +R Q +R++ ++ W+ E P++ + L + L + Q
Sbjct: 772 PMVARKQKLADSLRLQQLFRDVEDE-ETWIREKE--PIAASTNRGKDLIGVQNLLKKHQA 828
Query: 2134 KEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLA 2193
+ + + G ++ AE ++A+L E+ +KW++ + ++++
Sbjct: 829 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAE-DVKAKLHELNQKWEALKAKASQRRQD-- 885
Query: 2194 FLLKDWEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQMRCKE--LENAVGSWT 2249
L+D + ++ AD+ E ++K + S +E AE + K L + + ++
Sbjct: 886 --LEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYG 943
Query: 2250 DDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN----E 2305
+ L + ++ D E V L E+ ++++++ I LN +
Sbjct: 944 SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKD 1003
Query: 2306 WAVFSEKNKE---LCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQ 2362
W +++ ++ +++ S + + L+EE Q IA+ QE +I Q
Sbjct: 1004 WWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEE---------QGSIALRQE-QIDNQ- 1052
Query: 2363 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 2422
R+ K +A + ++ +V + + LL+L R K + E L + + L+
Sbjct: 1053 --TRITK-----EAGSVSLRMKQVEELYHSLLELGEKR-KGMLEKSCKKFMLFREANELQ 1104
Query: 2423 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE------V 2476
W+ E+ L V + E+++ + + Q+D++ + + + + + E +
Sbjct: 1105 QWINEKEAALTSEEV--GADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGL 1162
Query: 2477 LLHDCDAC------------ATDAECDSIQQATR-------------NLDRRWRNICAMS 2511
+ + A TD++ S ++ R L+ RWR++ ++
Sbjct: 1163 MAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLA 1222
Query: 2512 MERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQR 2571
ER + + Q+F D ++W++ + A + G + +K E F+R
Sbjct: 1223 EERSQLLGSAHEV-QRFHRDADETKEWIEEKNQ-ALNTDNYGHDLASVQALQRKHEGFER 1280
Query: 2572 QVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR----- 2626
+ ++ + + RL ++ +SA L++ E NQ W +L KR +
Sbjct: 1281 DLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSH 1339
Query: 2627 -LKHFIGQREEFETARDSI--LVWLTEMDLQLTNIEHFSE------CDVQAKIKQLKAF- 2676
L+ F+ + + + I LV E+ +T E E ++ A+ +AF
Sbjct: 1340 DLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFE 1399
Query: 2677 ---QQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEE--------ELDELRRYCQ---- 2721
QQ ++ H +I + + L ++ L+ A ++ EL R C+
Sbjct: 1400 QFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN 1459
Query: 2722 -----EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDS--AALSDLHWHDRSADSLLS 2774
E F E L + +H+ D+ + +++ AAL +A
Sbjct: 1460 WMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAK 1519
Query: 2775 PQPSS--NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRAL-PSED 2831
SS N L + L+++ + + ++ D D ++E+ +S L + D
Sbjct: 1520 GDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVD---EIEAWISEKLQTASD 1576
Query: 2832 EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELD 2891
E +D + L + H A E+ +L D R I ++I
Sbjct: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEA---ELHANADRIRGVIDMGNSLIER--------- 1624
Query: 2892 TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQ 2951
G C+ S D+VK + A + D+W+ L +
Sbjct: 1625 ----------GACAGSEDAVK-----------------------ARLAALADQWQFLVQK 1651
Query: 2952 ALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKE 3011
+ K ++K+ K Q FN+ + WL + E L + D+ ++ +KK +
Sbjct: 1652 SAEKSQKLKE-ANKQQNFNTGIKDFDFWLSEVE---ALLASEDYGKDLASVNNLLKKHQL 1707
Query: 3012 LQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQD 3071
L+ + + + +N + + + ++ ++D+ +NGR+ ++ S+ R L +
Sbjct: 1708 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE 1767
Query: 3072 ALMQCQGFHEM 3082
+ Q F +M
Sbjct: 1768 SHRLHQFFRDM 1778
Score = 151 bits (381), Expect = 1e-35
Identities = 487/2443 (19%), Positives = 948/2443 (38%), Gaps = 349/2443 (14%)
Query: 453 LEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDS--LQSISTKMEAIELKL 510
++PS L + E + V+ R + R+QK +DS Q E +E +
Sbjct: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
Query: 511 SE-----SPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPA 562
E S E + P + ++ +HQA E+ I +L + ++SE A
Sbjct: 61 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDET-GNLMISEGHFA--- 116
Query: 563 EQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSW 622
+E + T M+ + +LL EK+ ++ + Q Q L +Y E +++ W
Sbjct: 117 ------------SETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDW 164
Query: 623 LLSTKATLDT-ALSPPKEPMD-MEAQLMDCQNMLVEIEQKVVALSELSV------HNENL 674
+ +A + + L E ++ ++ + + Q + E++V +++ + H E
Sbjct: 165 INDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE 224
Query: 675 LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ-EKEESDVDLTATQS 733
L+ K + +++ +RLKG L LQR Q + G A+ ++ DVD T +
Sbjct: 225 LI------KTKQDEVNAAWQRLKG--LALQR-----QGKLFGAAEVQRFNRDVDETISWI 271
Query: 734 PGVQEWLAQAR-TTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETS 792
++ +A Q+ L++ + LE++LA + ++++ + + + H + T
Sbjct: 272 KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ 331
Query: 793 GDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEF----------STKQKLLQNVLE 842
+ + + E + +AE R+ Q F T+ K L N E
Sbjct: 332 IQVKREELITNWE---QIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
Query: 843 QEQE----QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS------SQ 892
+ + L R + ++ + D+S L G + A +EV S+
Sbjct: 389 LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAG-HYASDEVREKLTVLSE 447
Query: 893 SGGAKRQSIHLEQKLYDGVSATSTWLDDVEE----RLFVATALLPEETETCLFNQEILAK 948
A + L ++ Y+ + D E+ LL E+ L + E L K
Sbjct: 448 ERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLK 507
Query: 949 D----IKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTL---GCLLGRLSLLDSVVNQRCH 1001
K +S + +K L A +N +ED LL R + L +R
Sbjct: 508 KHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRA 567
Query: 1002 QMKE--RLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKE 1059
Q+ + LQQ ++LK S + K A + +++ Q E L
Sbjct: 568 QLADSFHLQQFFRDSDELK----SWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSA 623
Query: 1060 FDAGIIELKRRGDKL--------QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111
+ I L++ G KL M E+ L E + G + NQ
Sbjct: 624 NQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQ---- 679
Query: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH------M 1165
+ Q+ R ++D+ L + +A D +Q L KH + +H +
Sbjct: 680 QQQFNRNVEDIELWLYEVEGHLASDD--YGKDLTNVQNLQKKHALLEADVAAHQDRIDGI 737
Query: 1166 ILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL 1225
+ F+ F + + L+A+ A+ + R +L L Q+L
Sbjct: 738 TIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL--------QQL 789
Query: 1226 SRQLEVVESSIPSVGLVEENEDRLIDRITL------YQHLKSSLNEYQPKLYQVLDDGKR 1279
R +E E+ I + + +R D I + +Q L++ + ++P++ V G
Sbjct: 790 FRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
Query: 1280 LLIS--ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQS 1337
++ + D++++L++L + W + K S+ LE L+ +Y +++ + W++
Sbjct: 850 MVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQA-QQYFADANEAESWMRE 908
Query: 1338 A------------KDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLS 1385
+D E ++ + +L + A E ++ Q +
Sbjct: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD--E 966
Query: 1386 TGNQL--------------LRLKKVDTATLRSELSRIDSQWTDLLTN-----IPAVQEKL 1426
TG +L + +KK D TL L+ + W + N +PA K
Sbjct: 967 TGKELVLALYDYQEKSPREVTMKKGDILTL---LNSTNKDWWKVEVNDRQGFVPAAYVK- 1022
Query: 1427 HQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG------------YKAIHEYL 1474
+L + SR + E I+L + I ++ I G Y ++ E
Sbjct: 1023 -KLDPAQSASRENLLEEQGSIALRQEQID-NQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
Query: 1475 QKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV 1534
+K KG ++ +CK+ + F + LQ Q + K + T +E++GA
Sbjct: 1081 EKRKGM-LEKSCKKFML-FREANELQ---QWINEKEAALT--SEEVGA------------ 1121
Query: 1535 TEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDL 1594
++ +E L + + +++ ++ + E RLK +++ + + + E++
Sbjct: 1122 --DLEQVEVLQKKFDDFQKDL-------KANESRLKDINKVAEDLESEGLM-----AEEV 1167
Query: 1595 IKAKEKEV------EKIEQNGLALIQNKKEDVSSI-VMSTLRELGQTWANLDHMVGQLKI 1647
+++EV ++ + + ++ + V ++ ++++EL + W +L + +
Sbjct: 1168 QAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQ 1227
Query: 1648 LLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 1707
LL S + H+ A D+ ++ E +L + + + ++Q LQ E
Sbjct: 1228 LLGSAHEVQRFHRDA-DETKEWIEEKNQAL--------NTDNYGHDLASVQALQRKHEGF 1278
Query: 1708 ERSLQKFGSITNQL------LKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKAL 1761
ER L G N L L + HP E L E+N W++L + A+Q ++
Sbjct: 1279 ERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKR-ADQRKAKLGD 1337
Query: 1762 LQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVK 1821
QR+ + S + N + ++ ++A D T + + + T
Sbjct: 1338 SHDLQRFLSDFRDLMSWI-------NGIRGLVSSDELAKD--VTGAEALLERHQEHRTEI 1388
Query: 1822 DSLFFLHELGEQLKQQVDAS---AASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 1878
D+ + EQ QQ+ A A+ I+ L Q LE+A +++ L L+
Sbjct: 1389 DARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQ-CLEL 1447
Query: 1879 ETFAKSLEALEAWIVEAEEILQGQDPSHSSD-LSTIQERMEE----LKGQMLKFSSMAPD 1933
+ F + E E W+ E L +D S D + + ++ E+ + Q K +++
Sbjct: 1448 QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAF 1507
Query: 1934 LDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL--QSFLLQHQTFLEKCET 1991
D+L G+ D +R + L+R W + +Q E+ SKL L Q +++ E
Sbjct: 1508 ADQLIAAGH-YAKGDISSRRNEVLDR-WRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEA 1565
Query: 1992 WMEFLVQTEQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG 2049
W+ +QT + + N Q LL + + H+ F+AE+ + + +I G L+E+G
Sbjct: 1566 WISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERG 1625
Query: 2050 Q-VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSY 2108
D +L L++QWQ +++++ ++ + +Q Q + + WL EV
Sbjct: 1626 ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEA 1684
Query: 2109 LPMS-----GLGSVPIPLQQARTLFDEVQFKEKVF--LRQQGSYILTVEAGKQLLLSADS 2161
L S L SV L++ + L ++ E L Q ++T A S
Sbjct: 1685 LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSA---FDTSQVK 1741
Query: 2162 GAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL-----KDWEKCEKGIADSLEKLRTF 2216
+ +I+ S +L E + F + W K +K + S + R
Sbjct: 1742 DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDL 1801
Query: 2217 KKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISI--- 2273
Q+L H+ L AE E A+ D +LS DD +I
Sbjct: 1802 TG--VQNLRKKHKRLEAE---LAAHEPAIQGVLDTGKKLS------------DDNTIGKE 1844
Query: 2274 -LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN-- 2330
+ +R+ W+EL + R Q++ E L E+ F +E W+ + + V+
Sbjct: 1845 EIQQRLAQFVEHWKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDY 1903
Query: 2331 GDIL--IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH---ESKASEIEYKLGK 2385
GD L I+ +++K + ++ + + ++ + G+ L K ++ E+ +S+++ GK
Sbjct: 1904 GDTLAAIQGLLKK-HEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGK 1962
Query: 2386 VNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEE 2445
V+D L+ AA+ K + A Q + + +W+ E+ L +S
Sbjct: 1963 VSD-----LEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSS-- 2015
Query: 2446 IQRKLNEQQELQRDIEK-HSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 2504
+Q L +Q+ ++ G+A++ L + LL A + +I+ +L +RW
Sbjct: 2016 VQTLLTKQETFDAGLQAFQQEGIANITALKDQLL-----AAKHVQSKAIEARHASLMKRW 2070
Query: 2505 RNICAMSMERRLKIEETWRLWQK-------FLDDYSRFEDWLKSSERTAAFPSSSGVIYT 2557
+ A S R+ K+ E ++K F S F W +++E P +
Sbjct: 2071 SQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP-----VRC 2125
Query: 2558 VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQ---MVHEGNQRWD 2614
+ EE+K L+ + Q L R+ ++ S + + W
Sbjct: 2126 NSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR 2185
Query: 2615 NLQK-------RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 2667
NLQK + RR + R+EF ++ W+ E L D
Sbjct: 2186 NLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYL--------LDGS 2237
Query: 2668 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 2710
+++ + ++ K ++I A QL +K E L AA+ E
Sbjct: 2238 CMVEESGTLESQLEATKRKHQEIRAMRSQL-KKIEDLGAAMEE 2279
Score = 147 bits (371), Expect = 2e-34
Identities = 373/2042 (18%), Positives = 817/2042 (40%), Gaps = 278/2042 (13%)
Query: 1089 DMYDELMMIIGSRRSGLNQNLTLK-SQYERALQDLADLLETGQEK--MAGDQKIIVS--- 1142
D E + ++ R+ L + L+ QYE+ + +T Q M+ + +++
Sbjct: 436 DEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDL 495
Query: 1143 --SKEEIQQLLDKHKEYFQGL---ESHMILTETLFRKIIS---FAVQKETQFHTELMAQA 1194
S + ++ LL KH+++ + L E + + K+I +A++ L+++
Sbjct: 496 GDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRR 555
Query: 1195 SAVLKRAHKRGVELE---YILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLID 1251
+A+ +RA +R +L ++ + + DE + ++ +++ ++ L
Sbjct: 556 NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDE------AYKDPSNLQG 609
Query: 1252 RITLYQHLKSSLNEYQPKLYQVLDDGKRLLI--SISCSDLESQLNQLGECWLSNTNKMSK 1309
++ +Q ++ L+ Q ++ + G++L+ + ++ +++N++ W K
Sbjct: 610 KVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW-----KKLL 664
Query: 1310 ELHRLETILKHWTRYQSES----ADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 1365
E L+ I Q + D+ WL + L S ++L V++
Sbjct: 665 EATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLA-----SDDYGKDLTNVQNLQKK 719
Query: 1366 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEK 1425
+V A + Q D ++ + + +++ L + A ++K
Sbjct: 720 HALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
Query: 1426 L-HQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 1484
L L++ +L + + +WI E + K+ IG + L+K++ + +I
Sbjct: 780 LADSLRLQQL--FRDVEDEETWIREKEPIAASTNRG-KDLIG---VQNLLKKHQALQAEI 833
Query: 1485 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 1544
+ + ++V Q + VE D +L +N+ W+ L+ +++ Q LE
Sbjct: 834 AGHEPRI----KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDS 889
Query: 1545 LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEK 1604
L++ +Y + ++W +E + D+ S + LK + L + A ++
Sbjct: 890 LQA-QQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA 948
Query: 1605 IEQNGLALIQN----KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHK 1660
+ + + Q E +V++ ++ + G + LL S W K
Sbjct: 949 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDW--WK 1006
Query: 1661 VAFDKINSYL-------MEARYSLSRFRLLT--GSLEAVQVQVDNLQNLQDDLEKQERSL 1711
V + ++ ++ S SR LL GS+ Q Q+DN Q R
Sbjct: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDN----------QTRIT 1056
Query: 1712 QKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKAL--LQLWQRYK 1769
++ GS++ ++ + E L ++L E+ + +LE+ ++ + LQ W K
Sbjct: 1057 KEAGSVSLRMKQ------VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEK 1110
Query: 1770 DY---SKQCASTVQQQE------DRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTV 1820
+ S++ + ++Q E D + LKA ++ ++VA ++ + + + V
Sbjct: 1111 EAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAV 1170
Query: 1821 KDSLFFLHELGEQLKQQVDASAASAIQSDQL------------SLSQHLCALEQALCKQQ 1868
+ + G + + D+ AS +S +L L++ +L+Q L +++
Sbjct: 1171 QQQEVY----GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ-LAEER 1225
Query: 1869 TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFS 1928
+ L + + F + + + WI E + L + H DL+++Q + +G +
Sbjct: 1226 SQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGH--DLASVQALQRKHEGFERDLA 1283
Query: 1929 SMAPDLDRLNELGYRLPLNDKEI-----KRMQNLNRHWSLISSQTTERFSKL------QS 1977
++ ++ L E RL + E ++ LN+ WS + + +R +KL Q
Sbjct: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQR 1343
Query: 1978 FLLQHQTFLEKCETWMEFL--VQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQIL 2035
FL + + +W+ + + + +LA +++G + LLE+ + H + E+ +R
Sbjct: 1344 FLSDFRDLM----SWINGIRGLVSSDELAKDVTGA-EALLERHQEH---RTEIDARAGTF 1395
Query: 2036 HSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 2095
+ GQ+LL G E KL +L + + + QRR ++D Q + Q +
Sbjct: 1396 QAFEQFGQQLLAHGHYAS-PEIKQKLDILDQERADLEKAWVQRRMMLD-QCLELQLFHRD 1453
Query: 2096 AEKLRKWLV-EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQ 2154
E+ W+ ++L G L L + + +K + Q I ++A
Sbjct: 1454 CEQAENWMAAREAFLNTEDKGD---SLDSVEALIKKHEDFDKA-INVQEEKIAALQAFAD 1509
Query: 2155 LLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF------LLKDWEKCEKGIAD 2208
L++A A+ + + E+ ++W+ ++ E++ KL +D ++ E I++
Sbjct: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE 1569
Query: 2209 SLEKLRTFKKK------LSQSLPDHHE------ELHAEQMRCKELENAVGSWTDDLTQLS 2256
L+ K LS+ L H + ELHA R + + +
Sbjct: 1570 KLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGV-------------ID 1616
Query: 2257 LLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKEL 2316
+ + A + R+ L QW+ L + + + Q++ E N+ F+ K+
Sbjct: 1617 MGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDF 1675
Query: 2317 CEWLTQMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHE 2373
WL+++E+ ++ D+ + K + + +I+ ++ L + L +S
Sbjct: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSS-A 1734
Query: 2374 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 2433
S+++ K +N R+Q + + A+R KL E+ + Q ++M +W+ E +L
Sbjct: 1735 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIK--EKKLL 1791
Query: 2434 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 2493
+ +Q + + L+ ++ H + VL+ + L D + I
Sbjct: 1792 VGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDD-----NTIGKEEI 1846
Query: 2494 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSG 2553
QQ W+ + ++ R ++EE+ +Q+F+ + E W+ + + T G
Sbjct: 1847 QQRLAQFVEHWKELKQLAAARGQRLEESLE-YQQFVANVEEEEAWI-NEKMTLVASEDYG 1904
Query: 2554 VIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQ-MVHEGNQR 2612
+ LKK EAF+ ++R + C+ Q ++ + N
Sbjct: 1905 DTLAAIQGLLKKHEAFETDF----------------TVHKDRVNDVCTNGQDLIKKNNHH 1948
Query: 2613 WDNLQKRVTSI---LRRLKHFIGQRE----------EFETARDSILVWLTEMDLQLTNIE 2659
+N+ ++ + + L+ QR+ +F D + W+ E + L +
Sbjct: 1949 EENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDD 2008
Query: 2660 HFSECD-VQAKIKQ-------LKAFQQE------------ISLNHNKIEQIIAQGEQLIE 2699
+ + VQ + + L+AFQQE ++ H + + I A+ L++
Sbjct: 2009 YGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMK 2068
Query: 2700 KSEPL--DAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSD--RELEL 2753
+ L ++A +++L E + + ++V + KK + E DL+D R L
Sbjct: 2069 RWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSL 2128
Query: 2754 EDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER--SGRDTPASVDSIPLEWDH 2811
E+ AL + H D SL S Q N L + ++S R S T +++++ W +
Sbjct: 2129 EEIKALREAH--DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRN 2186
Query: 2812 DYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRF 2871
+ ++ E + + ++E + ++F +A I++ L D
Sbjct: 2187 LQKIIKERELELQKEQRRQEENDKLRQEFAQHA--------NAFHQWIQETRTYLLDGSC 2238
Query: 2872 QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 2931
++++ L++ + + E + +K++E EE+L ++
Sbjct: 2239 MVEESGT-----------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL--ILDN 2285
Query: 2932 HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 2991
TE T G+ +W+ L +RM+ NL++ Q + G TEE L++
Sbjct: 2286 KYTEHSTVGLAQQWDQLDQLG----MRMQHNLEQQIQARNT-------TGVTEEALKEFS 2334
Query: 2992 RL 2993
+
Sbjct: 2335 MM 2336
Score = 117 bits (293), Expect = 2e-25
Identities = 343/1750 (19%), Positives = 691/1750 (39%), Gaps = 214/1750 (12%)
Query: 1551 YENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGL 1610
++ + + L+ W + ++ ++ D ++Q L+ Q E ++A + K+++ G
Sbjct: 49 FQRDAEELEKWIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGN 107
Query: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQ--LKILLKSVLDQWSSH-KVAFDKIN 1667
+I ++ S + + L EL + W L + + +K+L L Q+ + D IN
Sbjct: 108 LMI-SEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIN 166
Query: 1668 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 1727
+ ++ L LE V+V + Q D+ E + + +L++E HP
Sbjct: 167 D-----KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
Query: 1728 PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTN 1787
E + EVN W L + +A Q Q QR+ + S ++++E
Sbjct: 222 E-EELIKTKQDEVNAAWQRL-KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQL-- 277
Query: 1788 ELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA-I 1846
+ +D+A V ++ L + L ++D + L ++L+Q SA +
Sbjct: 278 -MASDDFGRDLAS--VQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQV 334
Query: 1847 QSDQLSLS----QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
+ ++L + + L A A LQ + D+ L +W+ E + ++
Sbjct: 335 KREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD-------LTSWVTEMKALINAD 387
Query: 1903 D-PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKRMQNLNR 1959
+ S + + +R +E KG++ D + L +D+ +++ L+
Sbjct: 388 ELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSE 447
Query: 1960 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQK-----------LAVEIS 2008
ER + L+ + L+ Q + E+C F TEQ L ++
Sbjct: 448 ----------ERAALLELWELRRQQY-EQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496
Query: 2009 GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQW 2068
+ + + HE F+ + ++++ + ++ +L++ D + LLS +
Sbjct: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRR- 555
Query: 2069 QGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLF 2128
+ RA +RR + Q +R+ +++L+ W+ E P LQ
Sbjct: 556 NALHERAMRRRAQLADSFHLQQFFRD-SDELKSWVNEKMKTATDEAYKDPSNLQ------ 608
Query: 2129 DEVQFKEKVF---LRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRL 2185
+VQ K + F L S I +E Q L+ + A+ + A + E+ WK
Sbjct: 609 GKVQ-KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667
Query: 2186 EEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE---LE 2242
E + KL + ++ + + D +L ++ + + D+ ++L Q K+ LE
Sbjct: 668 ELKGIKLREANQQ-QQFNRNVEDI--ELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLE 724
Query: 2243 NAVGSWTDDLTQLSLLKDTL--SAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 2300
V + D + +++ + + A++I ++ E L ++E L + R+Q++
Sbjct: 725 ADVAAHQDRIDGITIQARQFQDAGHFDAENIK---KKQEALVARYEALKEPMVARKQKLA 781
Query: 2301 ERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENK 2357
+ L +F + E W+ + E + ++ D++ + + K + Q EIA +
Sbjct: 782 DSLRLQQLFRDVEDEET-WIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 2358 IQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKN 2417
+ Q G + + H + A +++ KL ++N +W+ L + R + L+++L A QQ +
Sbjct: 841 KAVTQKGNAMVEEGHFA-AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQA-QQYFAD 898
Query: 2418 MSSLRTWLAHIESELAKPIVYDSC---NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLC 2474
+ +W+ E PIV + + + + L + + L D+ + + +
Sbjct: 899 ANEAESWMREKE-----PIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSI------- 946
Query: 2475 EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKI--EETWRLWQKFLDDY 2532
+ L +C QQ D + + + + K E T +
Sbjct: 947 QALREQAQSCR--------QQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLN 998
Query: 2533 SRFEDWLKS--SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELINKQ 2586
S +DW K ++R P++ +KK + Q E L + + L +Q
Sbjct: 999 STNKDWWKVEVNDRQGFVPAAY----------VKKLDPAQSASRENLLEEQGSIALRQEQ 1048
Query: 2587 YRRLARENRTDSACSL--KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSI 2644
R + + SL KQ+ + + +KR + + K F+ RE E +
Sbjct: 1049 IDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ--- 1105
Query: 2645 LVWLTEMDLQLTNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 2703
W+ E + LT+ E ++ + V+ K+ FQ+++ N ++++ I E L +SE
Sbjct: 1106 --WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL--ESEG 1161
Query: 2704 LDAAIIEEELDELRRYCQEVFGRVERYHK--------KLIRLPLPD----------DEHD 2745
L A EE+ +++ QEV+G + R K RL + +E
Sbjct: 1162 LMA----EEVQAVQQ--QEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERW 1215
Query: 2746 LSDRELELEDSAALSDLH----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS 2801
S ++L E S L H +H R AD N Q L ++ G D AS
Sbjct: 1216 RSLQQLAEERSQLLGSAHEVQRFH-RDADETKEWIEEKN------QALNTDNYGHDL-AS 1267
Query: 2802 VDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQ 2861
V + L+ H+ RDL +A+ + S E + + A L + L
Sbjct: 1268 VQA--LQRKHE-GFERDL-AALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSS 1323
Query: 2862 LGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEE 2921
LGK D + ++ + ++ R + +L + G L+ + D V E L+
Sbjct: 1324 LGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVSSDELAKD-VTGAEALLERH 1381
Query: 2922 EESLPGFVNLHSTETQT-AGVIDRWELLQAQALSK----ELRMKQNLQKWQQFNSDLNSI 2976
+E H TE AG +E Q L+ +KQ L Q +DL
Sbjct: 1382 QE--------HRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKA 1433
Query: 2977 WAWLGDTEEELEQLQRLE----------------LSTD-----IQTIELQIKKLKELQKA 3015
W ++ +LQ L+T+ + ++E IKK ++ KA
Sbjct: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKA 1493
Query: 3016 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 3075
++ ++ I ++ + + A D+ R +++ RW R+ + + E R L ++
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTL 1553
Query: 3076 CQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVAS 3135
Q ++ + E + +E +N+ L H++ + EL + R+
Sbjct: 1554 QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRG 1613
Query: 3136 LQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLLLK---EVSRHIKELEKLLDVSSSQQ 3191
+ DM L+ +A K ++ + ++ + L++ E S+ +KE K + ++ +
Sbjct: 1614 VIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK 1673
Query: 3192 DLSSWSSADE 3201
D W S E
Sbjct: 1674 DFDFWLSEVE 1683
Score = 112 bits (281), Expect = 5e-24
Identities = 467/2475 (18%), Positives = 938/2475 (37%), Gaps = 370/2475 (14%)
Query: 135 RETEELRQMIKIRLQNLQDAA-KDMKKFEAELKKLQAALEQAQAT----LTSPEVGRLSL 189
R+ EEL + I+ +LQ D KD + +L+K QA + QA + E G L +
Sbjct: 51 RDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI 110
Query: 190 KE------------QLSHRQH--LLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA 235
E HRQ LL +M K+ Q LR EDV+ + A
Sbjct: 111 SEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEA 170
Query: 236 ALRLQEEASRLQHTAIQQ-------------------CNIMQAAVVQYEQYEQEMKHLQQ 276
+ +E L+H + Q N A ++Q + E+E+ +Q
Sbjct: 171 IVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQ 230
Query: 277 --------LIEGAHREIEDKPVATSNIQELQAQISRH----------------------- 305
++G + + K + +Q +
Sbjct: 231 DEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASV 290
Query: 306 EELAQKIKGYQEQIASLNSKCKMLTMKAKHATML--LTVTEVEGLAEGTEDLDGELLPTP 363
+ L +K +G + +A+L K K L +A L+ T+++ E + E + T
Sbjct: 291 QALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELIT-NWEQIRTL 349
Query: 364 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYY 423
+A + + R L+ + + S V A +N D
Sbjct: 350 AAERHARLNDSYRLQRFLADFRDLT------------------SWVTEMKALINADELAS 391
Query: 424 QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKN---VISEKQR 480
AE L D + H + E + S A L + + ++ V+SE++
Sbjct: 392 DVAGAEAL-LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERA 450
Query: 481 TLYEALE-RQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQA-LMDEILMLQ 538
L E E R+Q+Y+ + ++L ++ + ++ M++ +A L++E L
Sbjct: 451 ALLELWELRRQQYEQCMD--------LQLFYRDTEQV----DNWMSKQEAFLLNEDL--G 496
Query: 539 DEINELQSSLAE-ELVSESCEADPAEQLALQSTLTVLA-------ERMSTIRMKASGKRQ 590
D ++ +++ L + E +S A + AL T L E ++T R +R
Sbjct: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRN 556
Query: 591 LLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLST-KATLDTALSPPKEPMDMEAQLMD 649
L E+ + + LQ++ ++DEL SW+ K D A K+P +++ ++
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY---KDPSNLQGKVQK 613
Query: 650 CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ--RAL 707
Q E+ + L + L+ + + KDE ++ L LLE + +
Sbjct: 614 HQAFEAELSANQSRIDALEKAGQKLI-DVNHYAKDEVAARMNEVISLWKKLLEATELKGI 672
Query: 708 HDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELE--QEL 765
++ N Q E D++L WL + + +S K+L Q L
Sbjct: 673 KLREANQQQQFNRNVE-DIEL----------WLYEV-----EGHLASDDYGKDLTNVQNL 716
Query: 766 AEQKSLLRS-VASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE 824
++ +LL + VA+ + I A DAG E K E + ++E
Sbjct: 717 QKKHALLEADVAAHQDRIDGITIQARQFQDAGH--------FDAENIKKKQE-ALVARYE 767
Query: 825 SLHQEF-STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLN 883
+L + + KQKL ++ Q+ + + + P+ +D V +LL
Sbjct: 768 ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQ 827
Query: 884 QAFEEVS---------SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPE 934
E++ +Q G A + H + V A L+ E L + +
Sbjct: 828 ALQAEIAGHEPRIKAVTQKGNAMVEEGHFAA---EDVKAKLHELNQKWEALKAKASQRRQ 884
Query: 935 ETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDS 994
+ E L Q+ A + S +K + S + ++ D+ + + L+ LS S
Sbjct: 885 DLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGS 944
Query: 995 VVNQRCHQMKERLQQILNFQNDL-KVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQA 1053
+ Q + QQ+ ++ K L +L D +++ ++
Sbjct: 945 SIQALREQAQSCRQQVAPTDDETGKELVLALYD------------YQEKSPREVT----- 987
Query: 1054 EDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKS 1113
+K+ D + D +VE Q + + +S +NL L+
Sbjct: 988 ---MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA-----YVKKLDPAQSASRENL-LEE 1038
Query: 1114 QYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFR 1173
Q AL+ +T K AG + + EE+ L + E +G+ E +
Sbjct: 1039 QGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGM------LEKSCK 1092
Query: 1174 KIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELS------R 1227
K + F E Q + + + A L + + G +LE + D+ Q++L +
Sbjct: 1093 KFMLFREANELQ---QWINEKEAALT-SEEVGADLEQVEVLQKKFDDFQKDLKANESRLK 1148
Query: 1228 QLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 1287
+ V + S GL+ E E + + + +Y + +E K + ++ +++
Sbjct: 1149 DINKVAEDLESEGLMAE-EVQAVQQQEVYGMMPR--DETDSKTASPWKSARLMVHTVATF 1205
Query: 1288 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ 1347
+ + +L E W S ++++E +L R+ ++ + W++ L
Sbjct: 1206 N---SIKELNERWRS-LQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALN---- 1257
Query: 1348 QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSR 1407
+ +L V+ F +++ A +S+ T +L++ L+ + +
Sbjct: 1258 -TDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTE 1316
Query: 1408 IDSQWTDLLTNIPAVQEKL---HQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNS 1464
++ W+ L + KL H LQ R ++MSWI+ + ++ DE K+
Sbjct: 1317 LNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFR----DLMSWINGIRGLVSSDE-LAKDV 1371
Query: 1465 IGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQD--VESKRSDKTDFAEQLGA 1522
G +A+ L++++ + +I+ + T Q Q+ + + K D +Q A
Sbjct: 1372 TGAEAL---LERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA 1428
Query: 1523 -MNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASV 1581
+ K+W ++ +L+ LE + + + + W +E L + + SV
Sbjct: 1429 DLEKAW-------VQRRMMLDQCLEL-QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
Query: 1582 QNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHM 1641
+ +K +D + I +E+++ ++ LI A +
Sbjct: 1481 EALIKKHEDFDKAINVQEEKIAALQAFADQLI----------------------AAGHYA 1518
Query: 1642 VGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQ 1701
G + VLD+W K + S L E++ +L +F +EA + LQ
Sbjct: 1519 KGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQ-TLQQFSRDVDEIEAWISE--KLQTAS 1575
Query: 1702 DDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIA----EQLQS 1757
D+ K ++Q ++ + + ++ V N+L+E A E
Sbjct: 1576 DESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVK 1635
Query: 1758 SK--ALLQLWQRYKDYSKQCASTVQQQEDRTN--------ELLKAATNKDIADDEVATWI 1807
++ AL WQ S + + +++ + N + + +A ++ +
Sbjct: 1636 ARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDL 1695
Query: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA-SAASAIQSDQLSLSQHLCALEQALCK 1866
N+LLK ++ + + + L Q D+ +SA + Q+ + K
Sbjct: 1696 ASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIK 1755
Query: 1867 QQTSLQAGVLD----YETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKG 1922
+ + L+ F + ++ E+WI E + ++ +D + DL+ +Q ++ K
Sbjct: 1756 SMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSED--YGRDLTGVQNLRKKHKR 1813
Query: 1923 QMLKFSSMAPDLDRLNELGYRLP----LNDKEIK-RMQNLNRHWSLISSQTTERFSKLQS 1977
+ ++ P + + + G +L + +EI+ R+ HW + R +L+
Sbjct: 1814 LEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
Query: 1978 FLLQHQTFL---EKCETWMEFLVQTEQKLAVEISGNYQHLLEQ----QRAHELFQAEMFS 2030
L ++Q F+ E+ E W+ +K+ + S +Y L + HE F+ +
Sbjct: 1874 SL-EYQQFVANVEEEEAWIN------EKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTV 1926
Query: 2031 RQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQ 2090
+ ++ + +GQ L+++ + + + K+ L+ + + + A QR+ +D +
Sbjct: 1927 HKDRVNDVCTNGQDLIKKNNHHE-ENISSKMKGLNGKVSDLEKAAAQRKAKLDEN-SAFL 1984
Query: 2091 RYREMAEKLRKWLVEV-SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTV 2149
++ A+ + W+ E + L G L +TL + + + Q I +
Sbjct: 1985 QFNWKADVVESWIGEKENSLKTDDYGR---DLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
Query: 2150 EAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADS 2209
A K LL+A A++A A + ++W +KKKL + K E
Sbjct: 2042 TALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVE------ 2095
Query: 2210 LEKLRTFKKKLS--QSLPDHHEELHAEQMRCKELE-------------NAVGSWTDDLTQ 2254
+ TF KK S S ++ EE + +RC LE +++ S D Q
Sbjct: 2096 -DLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQ 2154
Query: 2255 LSLLKDTLSAYISADD------ISILNERVELLQR--QWEELCHQLSLRRQQIGERLNEW 2306
L+ L + ++ A + + L E LQ+ + EL Q RRQ+ ++L +
Sbjct: 2155 LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQ- 2213
Query: 2307 AVFSEKNKELCEWLTQMESKVSQNGDILIEE------MIEKLKKDYQEEIAIAQENKIQL 2360
F++ +W+ + + + +G ++EE +E K+ +QE A+ + K ++
Sbjct: 2214 -EFAQHANAFHQWIQETRTYL-LDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLK-KI 2270
Query: 2361 QQMGERLAKA--------SHESKASEIEY-KLGKVNDRWQHLLD-LIAAR------VKKL 2404
+ +G + +A H + ++ +L ++ R QH L+ I AR + L
Sbjct: 2271 EDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEAL 2330
Query: 2405 KETLVAVQQLDKNMS 2419
KE + + DK+ S
Sbjct: 2331 KEFSMMFKHFDKDKS 2345
Score = 98.2 bits (243), Expect = 1e-19
Identities = 420/2240 (18%), Positives = 861/2240 (38%), Gaps = 314/2240 (14%)
Query: 27 KLTELHQQ---TIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 83
+L ELH+Q + + + KL QA L +Y E ++ WI + + ++
Sbjct: 123 RLMELHRQWELLLEKMREKGIKLLQAQK-LVQYLRECEDVMDWINDKEAIV-------TS 174
Query: 84 SQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQM 143
+L + + L ++ +E +++ A E++ +++Q A+L +E ++
Sbjct: 175 EELGQDLEHVEVLQKKFEEFQTDMAAHEERVN---------EVNQFAAKLIQEQHPEEEL 225
Query: 144 IKIRLQNLQDA-----------------AKDMKKFEAELKKLQAALEQAQATLTSPEVGR 186
IK + + A A ++++F ++ + + +++ + + S + GR
Sbjct: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR 285
Query: 187 LSLKEQLSHRQH--LLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEE-- 242
Q R+H L ++ +L+ KV+A LC A R+ + S PL ++++ E
Sbjct: 286 DLASVQALLRKHEGLERDLAALEDKVKA--LCAEADRLQQ----SHPLSATQIQVKREEL 339
Query: 243 ---------ASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS 293
+ +H + +Q + + + ++ LI S
Sbjct: 340 ITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE--------LAS 391
Query: 294 NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT----MLLTVTEVEGLA 349
++ +A + RH+E +I +++ S + + L +A+ LTV E A
Sbjct: 392 DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
Query: 350 EGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPV 409
L+ L + + R + + N ++ +
Sbjct: 452 L----LELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG--------DSL 499
Query: 410 ANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWE 469
+ +A + + + ++LSA+ + A + Y +E AT + L R
Sbjct: 500 DSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHY--AMEDVATRRDALLSRR-N 556
Query: 470 TLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQA 529
L ++ L ++ QQ ++DS + S E ++ E+ + + + ++ +HQA
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
Query: 530 LMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKR 589
E+ Q I+ L+ + ++L+ + A + +++ + + +K
Sbjct: 617 FEAELSANQSRIDALEKA-GQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGI--- 672
Query: 590 QLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD 649
+L E Q+Q R ++++ WL + L + D L +
Sbjct: 673 ---------KLREANQQQQFNR---NVEDIELWLYEVEGHLASD--------DYGKDLTN 712
Query: 650 CQNMLVEIEQKVVALSELSVHNENLLLEG---------------KAHTKDEAEQLAGKLR 694
QN+ QK AL E V ++G + K + E L +
Sbjct: 713 VQNL-----QKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYE 767
Query: 695 RLKGSLLELQRALHDKQLNMQGTAQEKEESDV----------------DLTATQSPGVQE 738
LK ++ ++ L D L +Q ++ E+ + DL Q+ +
Sbjct: 768 ALKEPMVARKQKLAD-SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKH 826
Query: 739 WLAQARTTWTQQRQSSLQQQ---------------KELEQELAEQKSLLRSVAS-RGEEI 782
QA + R ++ Q+ K EL ++ L++ AS R +++
Sbjct: 827 QALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDL 886
Query: 783 LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ-----MRMKWESLHQEFSTKQKLL 837
A + DA E + ++ + G +D+ + K E+L + S +
Sbjct: 887 EDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSI 946
Query: 838 QNVLEQEQEQVLYSRPNRLLSGVPL------YKGDVP---TQDKSAVTSLLDGLNQAF-- 886
Q + EQ Q P +G L Y+ P T K + +LL+ N+ +
Sbjct: 947 QALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWK 1006
Query: 887 EEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEIL 946
EV+ + G + +KL SA+ L +EE+ + AL E+ + NQ +
Sbjct: 1007 VEVNDRQGFVPAAYV---KKLDPAQSASRENL--LEEQ--GSIALRQEQID----NQTRI 1055
Query: 947 AKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLG--CLLGRLSLLDSVVNQR----- 999
K+ +S M + + L+ + ++E + L + L +N++
Sbjct: 1056 TKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALT 1115
Query: 1000 -------CHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQP--VAEQIEAI 1050
Q++ ++ +FQ DLK + L D + K+A E +AE+++A+
Sbjct: 1116 SEEVGADLEQVEVLQKKFDDFQKDLKANESRLKD-----INKVAEDLESEGLMAEEVQAV 1170
Query: 1051 QQAE-DGL---KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLN 1106
QQ E G+ E D+ + + + + +L + + L + R +
Sbjct: 1171 QQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEER----S 1226
Query: 1107 QNLTLKSQYERALQDLADLLETGQEK-MAGDQKIIVSSKEEIQQLLDKHKEYFQGL---- 1161
Q L + +R +D + E +EK A + +Q L KH+ + + L
Sbjct: 1227 QLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALG 1286
Query: 1162 ESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLD 1219
+ L ET R I S E + TEL S++ KRA +R +L + L
Sbjct: 1287 DKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFL- 1345
Query: 1220 EDQQELSRQLEVVESSIPSVGLVEE--NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 1277
D ++L + + + S L ++ + L++R +Q ++ ++ G
Sbjct: 1346 SDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER---HQEHRTEIDARAGTFQAFEQFG 1402
Query: 1278 KRLL---------ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSES 1328
++LL I L+ + L + W+ + + LE L H Q+E
Sbjct: 1403 QQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQ---CLELQLFHRDCEQAE- 1458
Query: 1329 ADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGN 1388
+W+ + + L + L+ V + +F K ++ Q +++ + +
Sbjct: 1459 ----NWMAAREAFL-----NTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFAD 1509
Query: 1389 QLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWIS 1448
QL+ + S + + +W L + + KL + Q + SR + E+ +WIS
Sbjct: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRD-VDEIEAWIS 1568
Query: 1449 ----LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQ 1504
+ KD NI+ S K + ++ QK++ F+ +++ + + V+ + +
Sbjct: 1569 EKLQTASDESYKDPTNIQLS---KLLSKH-QKHQAFEAELHANADRI----RGVIDMGNS 1620
Query: 1505 DVESKRSDKTDFA--EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF 1562
+E ++ A +L A+ WQ L EK Q L+ + ++ W
Sbjct: 1621 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKE-ANKQQNFNTGIKDFDFWL 1679
Query: 1563 ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSS 1622
E L + D ASV N LK Q LE I A E ++ + +L+ + D S
Sbjct: 1680 SEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQ 1739
Query: 1623 IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKV-----AFDKINSYLMEARYSL 1677
V + + + M + L SH++ D S++ E
Sbjct: 1740 -VKDKRDTINGRFQKIKSMAASRRAKLN------ESHRLHQFFRDMDDEESWIKEK---- 1788
Query: 1678 SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTL 1737
+LL GS E + +QNL+ ++ E L +L + +++ T
Sbjct: 1789 ---KLLVGS-EDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVL-DTGKKLSDDNTIGK 1843
Query: 1738 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 1797
+E+ R +E E Q + A Q + +Y +Q + V+++E NE + ++D
Sbjct: 1844 EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASED 1902
Query: 1798 IADDEVA-TWIQDCNDLLKGLGTV-KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQ 1855
D A + ++ + TV KD + + G+ L ++ + + I S L+
Sbjct: 1903 YGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEEN-ISSKMKGLNG 1961
Query: 1856 HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQE 1915
+ LE+A +++ L + F + +E+WI E E L+ D + DLS++Q
Sbjct: 1962 KVSDLEKAAAQRKAKLDENSA-FLQFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQT 2018
Query: 1916 RMEELKG-----QMLKFSSMAPDLDRLNELGYRLPLNDKEIK-RMQNLNRHWSLISSQTT 1969
+ + + Q + +A ++L + K I+ R +L + WS + + +
Sbjct: 2019 LLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSA 2078
Query: 1970 ERFSKL---QSFLLQHQ----TFLEKCETWMEFLVQTEQKLAVEISGN-YQHLLEQQRAH 2021
R KL QS + + TF +K + + E+ L + N + + + AH
Sbjct: 2079 ARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAH 2138
Query: 2022 ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGI 2081
+ F++ + S Q + + + R ++ +V + L W+ + + ++R
Sbjct: 2139 DAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKER--- 2194
Query: 2082 IDSQIRQWQRYREMAEKLRK 2101
+ ++++ QR +E +KLR+
Sbjct: 2195 -ELELQKEQRRQEENDKLRQ 2213
Score = 88.6 bits (218), Expect = 9e-17
Identities = 222/1185 (18%), Positives = 460/1185 (38%), Gaps = 147/1185 (12%)
Query: 2088 QWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 2147
++Q ++ AE+L KW+ E + P LQ + Q E G+ +
Sbjct: 45 RFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGK---LQKHQAFEAEVQANSGAIVK 101
Query: 2148 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEE------QKKKLAFLLKDWEK 2201
E G L++S A ++ L E+ +W+ ++ E Q +KL L++ E
Sbjct: 102 LDETGN-LMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED 160
Query: 2202 CEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDT 2261
I D E + T S+ L E + Q + +E + + + + + +++
Sbjct: 161 VMDWINDK-EAIVT-----SEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAK 214
Query: 2262 LSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLT 2321
L ++ ++ + + + W+ L L+L+RQ E F+ E W+
Sbjct: 215 LIQEQHPEE-ELIKTKQDEVNAAWQRL-KGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
Query: 2322 QMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE 2378
+ E ++ + D+ + + + + + ++A ++ L +RL + SH A++
Sbjct: 273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ-SHPLSATQ 331
Query: 2379 IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-AKPIV 2437
I+ K ++ W+ + L A R +L ++ +Q+ + L +W+ +++ + A +
Sbjct: 332 IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELA 390
Query: 2438 YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 2497
D +E + L+ QE + +I+ H S + LL A D +++
Sbjct: 391 SDVAGAEAL---LDRHQEHKGEIDAHEDSFKSADESGQALL-----AAGHYASDEVREKL 442
Query: 2498 RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 2557
L + + RR + E+ L Q F D + ++W+ S + G
Sbjct: 443 TVLSEERAALLELWELRRQQYEQCMDL-QLFYRDTEQVDNWM-SKQEAFLLNEDLGDSLD 500
Query: 2558 VAKEELKKFEAFQRQV---HECLTQLE------LINKQYRRLARENRTDSACSLKQMVHE 2608
+ LKK E F++ + E +T L+ + N Y R D+ S + +HE
Sbjct: 501 SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHE 560
Query: 2609 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQA 2668
R ++ + L+ F +E ++ W+ E T+ + ++Q
Sbjct: 561 RAMR----RRAQLADSFHLQQFFRDSDELKS-------WVNEKMKTATDEAYKDPSNLQG 609
Query: 2669 KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFG--- 2725
K+++ +AF+ E+S N ++I+ + G++LI+ + DE+ EV
Sbjct: 610 KVQKHQAFEAELSANQSRIDALEKAGQKLID--------VNHYAKDEVAARMNEVISLWK 661
Query: 2726 -RVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLS 2784
+E K I+L + + + ++E L ++ H S D NL
Sbjct: 662 KLLEATELKGIKLREANQQQQFNRNVEDIE--LWLYEVEGHLASDDYGKDLTNVQNLQKK 719
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR-DLESAMSRALPSEDEEGQDDKDFYLR 2843
A + +D +D I ++ D D E+ + +E + L+
Sbjct: 720 HALLEADVAAHQD---RIDGITIQARQFQDAGHFDAENIKKK------QEALVARYEALK 770
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL---DTSYKGYMKL 2900
+ A +++QL + ++D I++ E I S T G +L K + L
Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAAS-TNRGKDLIGVQNLLKKHQAL 829
Query: 2901 LGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK 2960
E + +K + K E G + + + +WE L+A+A + ++
Sbjct: 830 QAEIAGHEPRIKAVTQKGNAMVEE--GHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
Query: 2961 QNLQKWQQFNSDLNSIWAWL------------GDTEEELEQLQRLE--LSTDIQTIELQI 3006
+LQ QQ+ +D N +W+ G E+ E L + L +D+ I
Sbjct: 888 DSLQA-QQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSI 946
Query: 3007 KKLKELQKAVDHR---------KAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 3057
+ L+E ++ + K ++L++ + + + + D+ L+ N W +
Sbjct: 947 QALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWK 1006
Query: 3058 V-------------CSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
V L+ + ++ L++ QG + L E ID +
Sbjct: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG------SIALRQEQIDNQTR------ 1054
Query: 3105 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE---------- 3154
+A + KQ+ ++ H LLE + + + SC+ + + L+
Sbjct: 1055 ITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
Query: 3155 AKEKVHVIGNRLKLLLKEVSRHIKELE----KLLDVSSSQQDLSS 3195
E+V ++++L K+ K+L+ +L D++ +DL S
Sbjct: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES 1159
Score = 85.1 bits (209), Expect = 1e-15
Identities = 198/1069 (18%), Positives = 423/1069 (39%), Gaps = 140/1069 (13%)
Query: 2187 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVG 2246
E + F +D E+ EK I + L+ K +L ++ A + + A+
Sbjct: 41 EDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIV 100
Query: 2247 SWTDDLTQLSLLKDTLSAYISADDISILNERVELLQ--RQWEELCHQLS------LRRQQ 2298
L +T + IS + R L++ RQWE L ++ L+ Q+
Sbjct: 101 K----------LDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQK 150
Query: 2299 IGERLNEWAVFSEKNKELCEWLTQMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQE 2355
+ + L E +++ +W+ E+ V+ D+ E+++K +++Q ++A +E
Sbjct: 151 LVQYLREC-------EDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
Query: 2356 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 2415
++ Q +L + H + I+ K +VN WQ L L R KL VQ+ +
Sbjct: 204 RVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAAWQRLKGLALQRQGKLFGA-AEVQRFN 261
Query: 2416 KNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE 2475
+++ +W+ E +A S++ R L Q L R E +A++ + +
Sbjct: 262 RDVDETISWIKEKEQLMA---------SDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
Query: 2476 VLLHDCDACATD--AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYS 2533
L + D IQ L W I ++ ER ++ +++RL Q+FL D+
Sbjct: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL-QRFLADFR 371
Query: 2534 RFEDWLKSSERTAAFPSSSGVIYTVAKEE--LKKFEAFQRQVHECLTQLELINKQYRRLA 2591
W+ + A ++ + VA E L + + + ++ A
Sbjct: 372 DLTSWVTEMK---ALINADELASDVAGAEALLDRHQEHKGEID----------------A 412
Query: 2592 RENRTDSACSLKQ-MVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARDSILV 2646
E+ SA Q ++ G+ D +++++T + L+ + +R+++E D L
Sbjct: 413 HEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLF 472
Query: 2647 ---------WLTEMDLQLTNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQ 2696
W+++ + L N + D V+A +K+ + F++ +S KI + +
Sbjct: 473 YRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATK 532
Query: 2697 LIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDS 2756
LI+ + ++++ + R H++ +R R +L DS
Sbjct: 533 LIQNNH--------YAMEDVATRRDALLSRRNALHERAMR------------RRAQLADS 572
Query: 2757 AALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS 2816
L R +D L S + + + + + + + + E +
Sbjct: 573 FHLQQFF---RDSDELKS-WVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
Query: 2817 RDLESAMSRALP----SEDEEGQDDKDFY-----LRGAVGLSGDHSALESQIRQLGKALD 2867
LE A + + ++DE + L A L G +Q +Q + ++
Sbjct: 629 DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVE 688
Query: 2868 DSRFQIQQTENIIRSKTPTGPEL---DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 2924
D + + E + S G +L K + L + ++ D + + + ++ +++
Sbjct: 689 DIELWLYEVEGHLASDD-YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
Query: 2925 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
G + + + + ++ R+E L+ ++++ ++ +L+ Q F D+ W+ + E
Sbjct: 748 --GHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFR-DVEDEETWIREKE 804
Query: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 3044
R D+ ++ +KK + LQ + + I ++ + + D+
Sbjct: 805 PIAASTNR---GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDV 861
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
+ +L ++N +W+ + + + R L+D+L Q F + + M E PI
Sbjct: 862 KAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREK--------EPIV 913
Query: 3105 SNLDAEILQDHHKQLMQIKHELLESQL-----RVASLQDMSCQLLVNAEGTDCLEAKEKV 3159
+ D +D + L++ KHE L S L + +L++ + TD KE V
Sbjct: 914 GSTDYGKDEDSAEALLK-KHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELV 972
Query: 3160 HVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSV 3208
+ + + +EV+ +K+ + L ++S+ +D W + D G V
Sbjct: 973 LALYDYQEKSPREVT--MKKGDILTLLNSTNKD---WWKVEVNDRQGFV 1016
Score = 79.0 bits (193), Expect = 7e-14
Identities = 337/1826 (18%), Positives = 702/1826 (38%), Gaps = 278/1826 (15%)
Query: 3 LDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLEL 62
L+ A QK ++ N +A ++ ++ L ++ + E + KL +A + +++N +E
Sbjct: 631 LEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVED 689
Query: 63 ILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV-- 120
I W+ + + + ++ H L + ++ +T + +
Sbjct: 690 IELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGH 749
Query: 121 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180
+ E + ++ L E L++ + R Q L D+ + + F +++ + + + +
Sbjct: 750 FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFR-DVEDEETWIREKEPIAA 808
Query: 181 SPEVGR--LSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALR 238
S G+ + ++ L Q L +E+ +P+++AV +A+ + E A+
Sbjct: 809 STNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAM-VEEGHFAA--------- 858
Query: 239 LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI----EDKPVATS- 293
E+ H Q+ ++A Q Q ++ QQ A+ E +P+ S
Sbjct: 859 --EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
Query: 294 ----NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLA 349
+ +A + +HE L + Y I +L + A+ + T+
Sbjct: 917 DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQ-------AQSCRQQVAPTD----D 965
Query: 350 EGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR----S 405
E ++L L P V M G TLL+ ++ + N PA
Sbjct: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025
Query: 406 PSPVANTDASVNQD----IAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 461
P+ A+ + + + + Q + R+ +A + +E Y LE K
Sbjct: 1026 PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRK- 1084
Query: 462 GDLQRSWET---------LKNVISEKQRTL--------YEALERQQKYQDSLQSISTKME 504
G L++S + L+ I+EK+ L E +E QK D Q
Sbjct: 1085 GMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK------ 1138
Query: 505 AIELKLSESPEPGRSPESQMAEHQALM-DEILMLQDEINELQSSLAEELVSESCEADPAE 563
+LK +ES + ++ E + LM +E+ +Q + E+ + + ++S A P +
Sbjct: 1139 --DLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ--EVYGMMPRD-ETDSKTASPWK 1193
Query: 564 QLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWL 623
L + + + +QL EE+ QL E +QR+ +ADE W+
Sbjct: 1194 SARLMVHTVATFNSIKELNERWRSLQQLAEER--SQLLGSAHE--VQRFHRDADETKEWI 1249
Query: 624 LSTKATLDT-----------ALSPPKEPMDME-AQLMDCQNMLVEIEQKVVALSELSVHN 671
L+T AL E + + A L D N L E ++++ S +
Sbjct: 1250 EEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAED 1309
Query: 672 ENLLLEGKAHTKDEAEQLAGK---LRRLK-GSLLELQRALHDKQLNMQGTAQEKEESDVD 727
L+ K ++A GK R+ K G +LQR L D + M + D
Sbjct: 1310 ----LQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSD 1365
Query: 728 LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHS 787
A G ++ L++ +E E+ + ++ G+++L
Sbjct: 1366 ELAKDVTGA---------------EALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
Query: 788 AAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRM-----------------KWESLHQEF 830
A S + +K D+L QE + EK+ + +M + W + + F
Sbjct: 1411 YA--SPEIKQKLDILDQERA-DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF 1467
Query: 831 ---STKQKLLQNV---------------LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK 872
K L +V +++E+ L + ++L++ KGD+ ++ +
Sbjct: 1468 LNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSR-R 1526
Query: 873 SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL 932
+ V L E S+ G +S L+Q D V W + E+L A+
Sbjct: 1527 NEVLDRWRRLKAQMIEKRSKLG----ESQTLQQFSRD-VDEIEAW---ISEKLQTASDES 1578
Query: 933 PEETETCLFNQEILAKDIKEMSEEMDKNKNL--------FSQAFPENG---DNRDVIEDT 981
++ T + ++L+K K + E + + N + E G + D ++
Sbjct: 1579 YKD-PTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKAR 1637
Query: 982 LGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQ 1041
L L + L ++ ++KE +Q NF +K L++ + ++ +
Sbjct: 1638 LAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEALLASEDYGKDLA 1696
Query: 1042 PVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD-------EL 1094
V ++ Q E + + + +L + D L S + S+++D D ++
Sbjct: 1697 SVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTS--SAFDTSQVKDKRDTINGRFQKI 1754
Query: 1095 MMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE------EIQ 1148
+ SRR+ LN++ L Q+ R + D +E ++K++V S++ +Q
Sbjct: 1755 KSMAASRRAKLNESHRL-HQFFRDMDD--------EESWIKEKKLLVGSEDYGRDLTGVQ 1805
Query: 1149 QLLDKHKEYFQGLESH------MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAH 1202
L KHK L +H ++ T + ++ Q + + + + A
Sbjct: 1806 NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA 1865
Query: 1203 KRGVELEYILETW---SHLDEDQQELSRQLEVVES-----SIPSV-GLVEENE------- 1246
RG LE LE ++++E++ ++ ++ +V S ++ ++ GL++++E
Sbjct: 1866 ARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT 1925
Query: 1247 ---DRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSN 1303
DR+ D T Q L N ++ IS L +++ L +
Sbjct: 1926 VHKDRVNDVCTNGQDLIKKNNHHEEN------------ISSKMKGLNGKVSDLEKAAAQR 1973
Query: 1304 TNKMSKELHRLETILKHWTRYQSESADLIH-WLQSAKDRLEFWTQQSVTVPQELEMVRDH 1362
K+ + L+ +W AD++ W+ ++ L ++ ++L V+
Sbjct: 1974 KAKLDENSAFLQF---NW------KADVVESWIGEKENSL-----KTDDYGRDLSSVQTL 2019
Query: 1363 LNAFLEFSKEVDA-QSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPA 1421
L F + A Q +++ + +QLL K V + + + + + +W+ LL N A
Sbjct: 2020 LTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2079
Query: 1422 VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHE---YLQKYK 1478
++KL + Q S + + E+++ + + ++ E + +
Sbjct: 2080 RKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHD 2139
Query: 1479 GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEK- 1537
F+ ++ Q + + + QI S V S + T F + A+ ++W+ LQ ++ E+
Sbjct: 2140 AFRSSLSSAQADFNQLAELDRQIKSFRVAS--NPYTWFT--MEALEETWRNLQKIIKERE 2195
Query: 1538 --IQLLEGLLES----WSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQD 1590
+Q + E E+ + W ET+ L + + ++++ L+ +
Sbjct: 2196 LELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKR 2255
Query: 1591 LEDLIKAKEKEVEKIEQNGLA-----LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 1645
I+A +++KIE G A ++ NK + S++ L Q W LD + ++
Sbjct: 2256 KHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTV------GLAQQWDQLDQLGMRM 2309
Query: 1646 KILLKSVLDQWSSHKVAFDKINSYLM 1671
+ L+ + ++ V + + + M
Sbjct: 2310 QHNLEQQIQARNTTGVTEEALKEFSM 2335
Score = 51.2 bits (121), Expect = 2e-05
Identities = 129/721 (17%), Positives = 287/721 (39%), Gaps = 55/721 (7%)
Query: 2491 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPS 2550
+ IQ+ + + R+ +S RR K+E+++R +Q F D E W++ + A+ +
Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 2551 SSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 2610
T + +L+K +AF+ +V + +++ + E S +++ + E +
Sbjct: 72 YKDP--TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE-TIRTRLMELH 128
Query: 2611 QRWDNLQKRVTSILRRLKHFIGQR-EEFETARDSILVWLTEMDLQLTNIEHFSECD-VQA 2668
++W+ L +++ + +K Q+ ++ + ++ W+ + + +T+ E + + V+
Sbjct: 129 RQWELLLEKMRE--KGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEV 186
Query: 2669 KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVE 2728
K+ + FQ +++ + ++ ++ +LI++ P + +I+ + DE+ Q + G
Sbjct: 187 LQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLKGLAL 245
Query: 2729 RYHKKLIRLP----LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLS 2784
+ KL D + E E A D S +LL L+
Sbjct: 246 QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 2785 LAQP------LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDK 2838
+ ++R + P S I ++ + +L + E R L +E +D
Sbjct: 306 ALEDKVKALCAEADRLQQSHPLSATQIQVKRE---ELITNWEQI--RTLAAERHARLND- 359
Query: 2839 DFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYM 2898
+ L+ + D ++ ++++ L A D+ + E ++ E+D +
Sbjct: 360 SYRLQRFLADFRDLTSWVTEMKALINA-DELASDVAGAEALLDRHQEHKGEIDAHEDSFK 418
Query: 2899 KLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 2958
S ++ H +E L + A +++ WEL + Q
Sbjct: 419 ----SADESGQALLAAGHYASDEVRE-----KLTVLSEERAALLELWELRRQQ------- 462
Query: 2959 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDH 3018
+ Q F D + W+ E L +L + ++E +KK ++ +K++
Sbjct: 463 -YEQCMDLQLFYRDTEQVDNWMSKQE---AFLLNEDLGDSLDSVEALLKKHEDFEKSLSA 518
Query: 3019 RKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG 3078
++ I +++ + + Q + D+ R + R + + R L D+ Q
Sbjct: 519 QEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQF 578
Query: 3079 FHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQD 3138
F + + E + +E SNL ++ Q H + EL +Q R+ +L+
Sbjct: 579 FRDSDELKSWVNEKMKTATDEAYKDPSNLQGKV-QKH----QAFEAELSANQSRIDALEK 633
Query: 3139 MSCQLL-VNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK--ELEKLLDVSSSQQDLSS 3195
+L+ VN D + A+ VI KLL + IK E + + + +D+
Sbjct: 634 AGQKLIDVNHYAKDEVAARMN-EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIEL 692
Query: 3196 W 3196
W
Sbjct: 693 W 693
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 168 bits (425), Expect = 9e-41
Identities = 409/2134 (19%), Positives = 847/2134 (39%), Gaps = 246/2134 (11%)
Query: 1047 IEAIQQAEDGLKEFDAGIIELKRRG-----DKLQVEQP--SMQELSKLQDM---YDELMM 1096
++A+ + +GL E D +E K + D+LQ P + Q K +++ ++++
Sbjct: 290 VQALLRKHEGL-ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT 348
Query: 1097 IIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMA---GDQKIIVSSKEEIQQLLDK 1153
+ R + LN + L +R L D DL E A D+ + S + LLD+
Sbjct: 349 LAAERHARLNDSYRL----QRFLADFRDLTSWVTEMKALINADE--LASDVAGAEALLDR 402
Query: 1154 HKEYFQGLESHMILTETLFRKIISF--AVQKETQFHTELMAQASAVLKRAHKRGVELEYI 1211
H+E+ +++H E F+ A+ + ++ + + VL +EL +
Sbjct: 403 HQEHKGEIDAH----EDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWEL 458
Query: 1212 LETWSHLDEDQQELSRQLEVVES--SIPSVGLVEENEDRLIDRITL----YQHLKSSLNE 1265
D Q R E V++ S L+ E+ +D + ++ + SL+
Sbjct: 459 RRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSA 518
Query: 1266 YQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILK---HWT 1322
+ K+ LD+ LI + +E + + LS N + + R L H
Sbjct: 519 QEEKI-TALDEFATKLIQNNHYAMEDVATRR-DALLSRRNALHERAMRRRAQLADSFHLQ 576
Query: 1323 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE-MVRDHLNAFLEFSKEVDAQSSLKS 1381
++ +S +L W+ ++++ T ++ P L+ V+ H F E+ A S
Sbjct: 577 QFFRDSDELKSWVN---EKMKTATDEAYKDPSNLQGKVQKHQ----AFEAELSANQSRID 629
Query: 1382 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 1441
++ G +L+ + + + ++ + S W LL KL + + +R+ +
Sbjct: 630 ALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN-VE 688
Query: 1442 EVMSWISLMENVIQKDE--DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 1499
++ W+ +E + D+ ++ N + +K+ + D+ Q +D +
Sbjct: 689 DIELWLYEVEGHLASDDYGKDLTN------VQNLQKKHALLEADVAAHQDRIDGITIQAR 742
Query: 1500 QISSQDVESKRSDKTDFAEQLGAMNKSWQIL-QGLVTEKIQLLEGLLESWSEYENNVQCL 1558
Q ++ D + ++ A+ ++ L + +V K +L + L + +V+
Sbjct: 743 QFQ----DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL--RLQQLFRDVEDE 796
Query: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKE 1618
+TW +E +R D VQN LK Q L+ I E ++ + Q G A+++ +
Sbjct: 797 ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGH 855
Query: 1619 DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 1678
+ V + L EL Q W L Q + L+ L Q + ++ S++ E
Sbjct: 856 FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESWMREK----- 909
Query: 1679 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE---CHPPVTETLTN 1735
+ GS + + + D+ + L E L +GS L ++ C V T
Sbjct: 910 --EPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDE 966
Query: 1736 TLKEVNMRWNNLLEEIAEQLQSSKA--LLQLWQRYKDYSKQCASTVQ------------- 1780
T KE+ + + E+ ++ K L L KD+ K + Q
Sbjct: 967 TGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDP 1026
Query: 1781 ----QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 1836
+E+ E A ++ D++ ++ + + V++ L ELGE+ K
Sbjct: 1027 AQSASRENLLEEQGSIALRQEQIDNQTRI-TKEAGSVSLRMKQVEELYHSLLELGEKRKG 1085
Query: 1837 QVDASAAS-AIQSDQLSLSQHLCALEQALCKQQTSL---QAGVLD--YETFAKSLEALEA 1890
++ S + + L Q + E AL ++ Q VL ++ F K L+A E+
Sbjct: 1086 MLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANES 1145
Query: 1891 WIVEAEEILQGQDPS--HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLND 1948
+ + ++ + + + ++ +Q+ +E+ G M + + + RL ++
Sbjct: 1146 RLKDINKVAEDLESEGLMAEEVQAVQQ--QEVYGMMPRDETDSKTASPWKSA--RLMVHT 1201
Query: 1949 -KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 2007
++ LN W + ER S+L + Q F + E++ + Q L +
Sbjct: 1202 VATFNSIKELNERWRSLQQLAEER-SQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD- 1259
Query: 2008 SGNYQHLLEQ----QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTL 2063
NY H L QR HE F+ ++ + ++S+ +RL+ Q + ++ K T
Sbjct: 1260 --NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTE 1316
Query: 2064 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 2123
L+ W + +RA QR+ + QR+ L W+ + L S + +
Sbjct: 1317 LNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIRGLVSS--DELAKDVTG 1373
Query: 2124 ARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA------ALQAELAEIQEK 2177
A L + Q + G++ + G+QLL + L E A++++
Sbjct: 1374 AEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKA 1433
Query: 2178 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMR 2237
W M L +Q +L +D E+ E +A L T K D + + A +
Sbjct: 1434 WVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK------GDSLDSVEALIKK 1486
Query: 2238 CKELENAVGSWTDDLTQLSLLKDTLSA--YISADDISILNERVELLQRQWEELCHQLSLR 2295
++ + A+ + + L D L A + + DIS + R E+L R W L Q+ +
Sbjct: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDIS--SRRNEVLDR-WRRLKAQMIEK 1543
Query: 2296 RQQIGERLNEWAVFSEKNKELCEWLT---QMESKVSQNGDILIEEMIEKLKKDYQEEIAI 2352
R ++GE FS E+ W++ Q S S I+ +K + E A
Sbjct: 1544 RSKLGES-QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHAN 1602
Query: 2353 AQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ 2412
A + + + + + ++ +L + D+WQ L+ A + +KLKE Q
Sbjct: 1603 ADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA-NKQQ 1661
Query: 2413 QLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLN 2472
+ + WL+ +E+ LA S + L + Q L+ DI H + + +
Sbjct: 1662 NFNTGIKDFDFWLSEVEALLASEDYGKDLAS--VNNLLKKHQLLEADISAHEDRLKDLNS 1719
Query: 2473 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 2532
+ L+ ++ + ++ ++ R++ I +M+ RR K+ E+ RL Q F D
Sbjct: 1720 QADSLM-----TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ-FFRDM 1773
Query: 2533 SRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR 2592
E W+K ++ G T + KK + + ++ ++ + ++L+
Sbjct: 1774 DDEESWIK-EKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSD 1832
Query: 2593 ENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 2652
+N T ++Q + + + W L++ + +RL+ + + ++F + W+ E
Sbjct: 1833 DN-TIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINE-K 1889
Query: 2653 LQLTNIEHFSE--CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 2710
+ L E + + +Q +K+ +AF+ + +++ +++ + G+ LI+K+
Sbjct: 1890 MTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKN--------- 1940
Query: 2711 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 2770
+ + + +++ + K + D E + R+ +L++++A +W +
Sbjct: 1941 ------NHHEENISSKMKGLNGK-----VSDLEKAAAQRKAKLDENSAFLQFNWKADVVE 1989
Query: 2771 SLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSE 2830
S + + +S L+++ GRD + + + D L + ++ +
Sbjct: 1990 SWIGEKENS---------LKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALK 2040
Query: 2831 DE----EGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPT 2886
D+ + K R A L S L + K L +++ ++ E++ +
Sbjct: 2041 DQLLAAKHVQSKAIEARHA-SLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKK 2099
Query: 2887 GPELDTSYKG---------------YMKLLGEC----SSSIDSVKRLEHKLKEEEESLPG 2927
++ ++ +K L E SS+ S + ++L E + +
Sbjct: 2100 ASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKS 2159
Query: 2928 F---VNLHSTETQTAGVIDRWELLQAQALSKEL-------RMKQNLQKWQQFNSDLNSIW 2977
F N ++ T A + + W LQ +EL R ++N + Q+F N+
Sbjct: 2160 FRVASNPYTWFTMEA-LEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFH 2218
Query: 2978 AWLGDT-----------------EEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRK 3020
W+ +T E +LE +R +I+ + Q+KK+++L A++ +
Sbjct: 2219 QWIQETRTYLLDGSCMVEESGTLESQLEATKRKH--QEIRAMRSQLKKIEDLGAAME--E 2274
Query: 3021 AIILSINLCSPEFTQADSKESRDLQDRLSQMNGR 3054
A+IL ++T+ + D+L Q+ R
Sbjct: 2275 ALIL-----DNKYTEHSTVGLAQQWDQLDQLGMR 2303
Score = 162 bits (411), Expect = 4e-39
Identities = 352/1851 (19%), Positives = 740/1851 (39%), Gaps = 218/1851 (11%)
Query: 1324 YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV 1383
+Q ++ +L W+Q ++L+ + ++ P L+ L F EV A S +
Sbjct: 49 FQRDAEELEKWIQ---EKLQIASDENYKDPTNLQ---GKLQKHQAFEAEVQANSGAIVKL 102
Query: 1384 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPS-RHAISE 1442
TGN ++ + T+R+ L + QW LL + KL LQ KL +
Sbjct: 103 DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKL--LQAQKLVQYLRECED 160
Query: 1443 VMSWISLMENVIQKDEDNIKNSIGYKAIH-EYLQ-KYKGFKIDINCKQLTVDFVNQSVLQ 1500
VM WI+ E ++ +E +G H E LQ K++ F+ D+ + V+ VNQ +
Sbjct: 161 VMDWINDKEAIVTSEE------LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAK 214
Query: 1501 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 1560
+ + + KT E +N +WQ L+GL ++ L G E + +V +
Sbjct: 215 LIQEQHPEEELIKTKQDE----VNAAWQRLKGLALQRQGKLFGAAEV-QRFNRDVDETIS 269
Query: 1561 WFETQEKRLKQQHRIGDQASVQNAL-------KDCQDLEDLIKAKEKEVEKIEQN---GL 1610
W + +E+ + D ASVQ L +D LED +KA E ++++Q+
Sbjct: 270 WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSA 329
Query: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL 1670
IQ K+E EL W + + + L + F + S++
Sbjct: 330 TQIQVKRE-----------ELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWV 377
Query: 1671 MEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVT 1730
E + +L L + + +D Q + +++ E S + LL H
Sbjct: 378 TEMK-ALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH---- 432
Query: 1731 ETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAS------TVQQQED 1784
EV + L EE A ALL+LW+ + +QC +Q ++
Sbjct: 433 ----YASDEVREKLTVLSEERA-------ALLELWELRRQQYEQCMDLQLFYRDTEQVDN 481
Query: 1785 RTNELLKAATNKDIAD--DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
++ N+D+ D D V ++ D K L ++ + L E +L Q + A
Sbjct: 482 WMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN-NHYA 540
Query: 1843 ASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
+ + + +L AL + +++ L A + F + + L++W+ E++
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQL-ADSFHLQQFFRDSDELKSWV--NEKMKTAT 597
Query: 1903 DPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-----PLNDKEIKRMQNL 1957
D ++ D S +Q ++++ + + S+ +D L + G +L D+ RM +
Sbjct: 598 DEAY-KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEV 656
Query: 1958 NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG----NYQH 2013
W + T + KL+ Q Q F E +L + E LA + G N Q+
Sbjct: 657 ISLWKKLLEATELKGIKLRE-ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQN 715
Query: 2014 LLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIR 2073
L Q+ H L +A++ + Q + I I ++ + G D + K L +++ +
Sbjct: 716 L---QKKHALLEADVAAHQDRIDGITIQARQFQDAGHF-DAENIKKKQEALVARYEALKE 771
Query: 2074 RAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQF 2133
R+ + +R Q +R++ ++ W+ E P++ + L + L + Q
Sbjct: 772 PMVARKQKLADSLRLQQLFRDVEDE-ETWIREKE--PIAASTNRGKDLIGVQNLLKKHQA 828
Query: 2134 KEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLA 2193
+ + + G ++ AE ++A+L E+ +KW++ + ++++
Sbjct: 829 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAE-DVKAKLHELNQKWEALKAKASQRRQD-- 885
Query: 2194 FLLKDWEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQMRCKE--LENAVGSWT 2249
L+D + ++ AD+ E ++K + S +E AE + K L + + ++
Sbjct: 886 --LEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYG 943
Query: 2250 DDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN----E 2305
+ L + ++ D E V L E+ ++++++ I LN +
Sbjct: 944 SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKD 1003
Query: 2306 WAVFSEKNKE---LCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQ 2362
W +++ ++ +++ S + + L+EE Q IA+ QE +I Q
Sbjct: 1004 WWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEE---------QGSIALRQE-QIDNQ- 1052
Query: 2363 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 2422
R+ K +A + ++ +V + + LL+L R K + E L + + L+
Sbjct: 1053 --TRITK-----EAGSVSLRMKQVEELYHSLLELGEKR-KGMLEKSCKKFMLFREANELQ 1104
Query: 2423 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE------V 2476
W+ E+ L V + E+++ + + Q+D++ + + + + + E +
Sbjct: 1105 QWINEKEAALTSEEV--GADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGL 1162
Query: 2477 LLHDCDAC------------ATDAECDSIQQATR-------------NLDRRWRNICAMS 2511
+ + A TD++ S ++ R L+ RWR++ ++
Sbjct: 1163 MAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLA 1222
Query: 2512 MERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQR 2571
ER + + Q+F D ++W++ + A + G + +K E F+R
Sbjct: 1223 EERSQLLGSAHEV-QRFHRDADETKEWIEEKNQ-ALNTDNYGHDLASVQALQRKHEGFER 1280
Query: 2572 QVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFI 2631
+ ++ + + RL ++ +SA L++ E NQ W +L KR +L
Sbjct: 1281 DLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSH 1339
Query: 2632 GQREEFETARDSILVWLTEMDLQLTNIEHFSE-CDVQAKIKQLKAFQQEISLNHNKIEQI 2690
+ RD ++ W+ + +++ E + +A +++ + + EI +
Sbjct: 1340 DLQRFLSDFRD-LMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAF 1398
Query: 2691 IAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRE 2750
G+QL+ + I+++LD L + ER D E R
Sbjct: 1399 EQFGQQLLAHGH-YASPEIKQKLDILDQ---------ER----------ADLEKAWVQRR 1438
Query: 2751 LELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWD 2810
+ L+ L H A++ ++ + + L +E G D+ SV+++ ++
Sbjct: 1439 MMLDQCLELQLFHRDCEQAENWMAAREAF---------LNTEDKG-DSLDSVEAL-IKKH 1487
Query: 2811 HDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDH-----SALESQIRQLGKA 2865
D+D + +++ AL + ++ Y +G + + L++Q+ +
Sbjct: 1488 EDFDKAINVQEEKIAALQAFADQ-LIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546
Query: 2866 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 2925
L +S+ Q + ++ + +L T+ K S + E +L + +
Sbjct: 1547 LGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRI 1606
Query: 2926 PGFVNL--------------HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNS 2971
G +++ + + + A + D+W+ L ++ K ++K+ K Q FN+
Sbjct: 1607 RGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKE-ANKQQNFNT 1665
Query: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
+ WL + E L + D+ ++ +KK + L+ + + + +N +
Sbjct: 1666 GIKDFDFWLSEVE---ALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQAD 1722
Query: 3032 EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEM 3082
+ + ++ ++D+ +NGR+ ++ S+ R L ++ Q F +M
Sbjct: 1723 SLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDM 1773
Score = 148 bits (374), Expect = 8e-35
Identities = 370/2037 (18%), Positives = 815/2037 (40%), Gaps = 273/2037 (13%)
Query: 1089 DMYDELMMIIGSRRSGLNQNLTLK-SQYERALQDLADLLETGQEK--MAGDQKIIVS--- 1142
D E + ++ R+ L + L+ QYE+ + +T Q M+ + +++
Sbjct: 436 DEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDL 495
Query: 1143 --SKEEIQQLLDKHKEYFQGL---ESHMILTETLFRKIIS---FAVQKETQFHTELMAQA 1194
S + ++ LL KH+++ + L E + + K+I +A++ L+++
Sbjct: 496 GDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRR 555
Query: 1195 SAVLKRAHKRGVELE---YILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLID 1251
+A+ +RA +R +L ++ + + DE + ++ +++ ++ L
Sbjct: 556 NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDE------AYKDPSNLQG 609
Query: 1252 RITLYQHLKSSLNEYQPKLYQVLDDGKRLLI--SISCSDLESQLNQLGECWLSNTNKMSK 1309
++ +Q ++ L+ Q ++ + G++L+ + ++ +++N++ W K
Sbjct: 610 KVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW-----KKLL 664
Query: 1310 ELHRLETILKHWTRYQSES----ADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 1365
E L+ I Q + D+ WL + L S ++L V++
Sbjct: 665 EATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLA-----SDDYGKDLTNVQNLQKK 719
Query: 1366 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEK 1425
+V A + Q D ++ + + +++ L + A ++K
Sbjct: 720 HALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
Query: 1426 L-HQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 1484
L L++ +L + + +WI E + K+ IG + L+K++ + +I
Sbjct: 780 LADSLRLQQL--FRDVEDEETWIREKEPIAASTNRG-KDLIG---VQNLLKKHQALQAEI 833
Query: 1485 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 1544
+ + ++V Q + VE D +L +N+ W+ L+ +++ Q LE
Sbjct: 834 AGHEPRI----KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDS 889
Query: 1545 LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEK 1604
L++ +Y + ++W +E + D+ S + LK + L + A ++
Sbjct: 890 LQA-QQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA 948
Query: 1605 IEQNGLALIQN----KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHK 1660
+ + + Q E +V++ ++ + G + LL S W K
Sbjct: 949 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDW--WK 1006
Query: 1661 VAFDKINSYL-------MEARYSLSRFRLLT--GSLEAVQVQVDNLQNLQDDLEKQERSL 1711
V + ++ ++ S SR LL GS+ Q Q+DN Q R
Sbjct: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDN----------QTRIT 1056
Query: 1712 QKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKAL--LQLWQRYK 1769
++ GS++ ++ + E L ++L E+ + +LE+ ++ + LQ W K
Sbjct: 1057 KEAGSVSLRMKQ------VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEK 1110
Query: 1770 DY---SKQCASTVQQQE------DRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTV 1820
+ S++ + ++Q E D + LKA ++ ++VA ++ + + + V
Sbjct: 1111 EAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAV 1170
Query: 1821 KDSLFFLHELGEQLKQQVDASAASAIQSDQL------------SLSQHLCALEQALCKQQ 1868
+ + G + + D+ AS +S +L L++ +L+Q L +++
Sbjct: 1171 QQQEVY----GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ-LAEER 1225
Query: 1869 TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFS 1928
+ L + + F + + + WI E + L + H DL+++Q + +G +
Sbjct: 1226 SQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGH--DLASVQALQRKHEGFERDLA 1283
Query: 1929 SMAPDLDRLNELGYRLPLNDKEI-----KRMQNLNRHWSLISSQTTERFSKL------QS 1977
++ ++ L E RL + E ++ LN+ WS + + +R +KL Q
Sbjct: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQR 1343
Query: 1978 FLLQHQTFLEKCETWMEFL--VQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQIL 2035
FL + + +W+ + + + +LA +++G + LLE+ + H + E+ +R
Sbjct: 1344 FLSDFRDLM----SWINGIRGLVSSDELAKDVTGA-EALLERHQEH---RTEIDARAGTF 1395
Query: 2036 HSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 2095
+ GQ+LL G E KL +L + + + QRR ++D Q + Q +
Sbjct: 1396 QAFEQFGQQLLAHGHYAS-PEIKQKLDILDQERADLEKAWVQRRMMLD-QCLELQLFHRD 1453
Query: 2096 AEKLRKWLV-EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQ 2154
E+ W+ ++L G L L + + +K + Q I ++A
Sbjct: 1454 CEQAENWMAAREAFLNTEDKGD---SLDSVEALIKKHEDFDKA-INVQEEKIAALQAFAD 1509
Query: 2155 LLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF------LLKDWEKCEKGIAD 2208
L++A A+ + + E+ ++W+ ++ E++ KL +D ++ E I++
Sbjct: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE 1569
Query: 2209 SLEKLRTFKKKLSQSLPDHHE-------ELHAEQMRCKELENAVGSWTDDLTQLSLLKDT 2261
L+ K ++ H+ ELHA R + + + +
Sbjct: 1570 KLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGV-------------IDMGNSL 1616
Query: 2262 LSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLT 2321
+ A + R+ L QW+ L + + + Q++ E N+ F+ K+ WL+
Sbjct: 1617 IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLS 1675
Query: 2322 QMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE 2378
++E+ ++ D+ + K + + +I+ ++ L + L +S S+
Sbjct: 1676 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSS-AFDTSQ 1734
Query: 2379 IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 2438
++ K +N R+Q + + A+R KL E+ + Q ++M +W+ E +L
Sbjct: 1735 VKDKRDTINGRFQKIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIK--EKKLLVGSED 1791
Query: 2439 DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 2498
+ +Q + + L+ ++ H + VL+ + L D + IQQ
Sbjct: 1792 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDD-----NTIGKEEIQQRLA 1846
Query: 2499 NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTV 2558
W+ + ++ R ++EE+ +Q+F+ + E W+ + + T G
Sbjct: 1847 QFVEHWKELKQLAAARGQRLEESLE-YQQFVANVEEEEAWI-NEKMTLVASEDYGDTLAA 1904
Query: 2559 AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQ-MVHEGNQRWDNLQ 2617
+ LKK EAF+ ++R + C+ Q ++ + N +N+
Sbjct: 1905 IQGLLKKHEAFETDF----------------TVHKDRVNDVCTNGQDLIKKNNHHEENIS 1948
Query: 2618 KRVTSI---LRRLKHFIGQRE----------EFETARDSILVWLTEMDLQLTNIEHFSEC 2664
++ + + L+ QR+ +F D + W+ E + L ++ +
Sbjct: 1949 SKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDL 2008
Query: 2665 D-VQAKIKQ-------LKAFQQE------------ISLNHNKIEQIIAQGEQLIEKSEPL 2704
VQ + + L+AFQQE ++ H + + I A+ L+++ L
Sbjct: 2009 SSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQL 2068
Query: 2705 --DAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSD--RELELEDSAA 2758
++A +++L E + + ++V + KK + E DL+D R LE+ A
Sbjct: 2069 LANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2128
Query: 2759 LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER--SGRDTPASVDSIPLEWDHDYDLS 2816
L + H D SL S Q N L + ++S R S T +++++ W + +
Sbjct: 2129 LREAH--DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2186
Query: 2817 RDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQT 2876
++ E + + ++E + ++F +A I++ L D ++++
Sbjct: 2187 KERELELQKEQRRQEENDKLRQEFAQHA--------NAFHQWIQETRTYLLDGSCMVEES 2238
Query: 2877 ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 2936
L++ + + E + +K++E EE+L ++ TE
Sbjct: 2239 GT-----------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL--ILDNKYTEH 2285
Query: 2937 QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL 2993
T G+ +W+ L +RM+ NL++ Q + G TEE L++ +
Sbjct: 2286 STVGLAQQWDQLDQLG----MRMQHNLEQQIQARNT-------TGVTEEALKEFSMM 2331
Score = 148 bits (373), Expect = 1e-34
Identities = 485/2441 (19%), Positives = 946/2441 (38%), Gaps = 350/2441 (14%)
Query: 453 LEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDS--LQSISTKMEAIELKL 510
++PS L + E + V+ R + R+QK +DS Q E +E +
Sbjct: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
Query: 511 SE-----SPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPA 562
E S E + P + ++ +HQA E+ I +L + ++SE A
Sbjct: 61 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDET-GNLMISEGHFA--- 116
Query: 563 EQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSW 622
+E + T M+ + +LL EK+ ++ + Q Q L +Y E +++ W
Sbjct: 117 ------------SETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDW 164
Query: 623 LLSTKATLDT-ALSPPKEPMD-MEAQLMDCQNMLVEIEQKVVALSELSV------HNENL 674
+ +A + + L E ++ ++ + + Q + E++V +++ + H E
Sbjct: 165 INDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE 224
Query: 675 LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ-EKEESDVDLTATQS 733
L+ K + +++ +RLKG L LQR Q + G A+ ++ DVD T +
Sbjct: 225 LI------KTKQDEVNAAWQRLKG--LALQR-----QGKLFGAAEVQRFNRDVDETISWI 271
Query: 734 PGVQEWLAQAR-TTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETS 792
++ +A Q+ L++ + LE++LA + ++++ + + + H + T
Sbjct: 272 KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ 331
Query: 793 GDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEF----------STKQKLLQNVLE 842
+ + + E + +AE R+ Q F T+ K L N E
Sbjct: 332 IQVKREELITNWE---QIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
Query: 843 QEQE----QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS------SQ 892
+ + L R + ++ + D+S L G + A +EV S+
Sbjct: 389 LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAG-HYASDEVREKLTVLSE 447
Query: 893 SGGAKRQSIHLEQKLYDGVSATSTWLDDVEE----RLFVATALLPEETETCLFNQEILAK 948
A + L ++ Y+ + D E+ LL E+ L + E L K
Sbjct: 448 ERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLK 507
Query: 949 D----IKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTL---GCLLGRLSLLDSVVNQRCH 1001
K +S + +K L A +N +ED LL R + L +R
Sbjct: 508 KHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRA 567
Query: 1002 QMKE--RLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKE 1059
Q+ + LQQ ++LK S + K A + +++ Q E L
Sbjct: 568 QLADSFHLQQFFRDSDELK----SWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSA 623
Query: 1060 FDAGIIELKRRGDKL--------QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111
+ I L++ G KL M E+ L E + G + NQ
Sbjct: 624 NQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQ---- 679
Query: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH------M 1165
+ Q+ R ++D+ L + +A D +Q L KH + +H +
Sbjct: 680 QQQFNRNVEDIELWLYEVEGHLASDD--YGKDLTNVQNLQKKHALLEADVAAHQDRIDGI 737
Query: 1166 ILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL 1225
+ F+ F + + L+A+ A+ + R +L L Q+L
Sbjct: 738 TIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL--------QQL 789
Query: 1226 SRQLEVVESSIPSVGLVEENEDRLIDRITL------YQHLKSSLNEYQPKLYQVLDDGKR 1279
R +E E+ I + + +R D I + +Q L++ + ++P++ V G
Sbjct: 790 FRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
Query: 1280 LLIS--ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQS 1337
++ + D++++L++L + W + K S+ LE L+ +Y +++ + W++
Sbjct: 850 MVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQA-QQYFADANEAESWMRE 908
Query: 1338 A------------KDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLS 1385
+D E ++ + +L + A E ++ Q +
Sbjct: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD--E 966
Query: 1386 TGNQL--------------LRLKKVDTATLRSELSRIDSQWTDLLTN-----IPAVQEKL 1426
TG +L + +KK D TL L+ + W + N +PA K
Sbjct: 967 TGKELVLALYDYQEKSPREVTMKKGDILTL---LNSTNKDWWKVEVNDRQGFVPAAYVK- 1022
Query: 1427 HQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG------------YKAIHEYL 1474
+L + SR + E I+L + I ++ I G Y ++ E
Sbjct: 1023 -KLDPAQSASRENLLEEQGSIALRQEQID-NQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
Query: 1475 QKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV 1534
+K KG ++ +CK+ + F + LQ Q + K + T +E++GA
Sbjct: 1081 EKRKGM-LEKSCKKFML-FREANELQ---QWINEKEAALT--SEEVGA------------ 1121
Query: 1535 TEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDL 1594
++ +E L + + +++ ++ + E RLK +++ + + + E++
Sbjct: 1122 --DLEQVEVLQKKFDDFQKDL-------KANESRLKDINKVAEDLESEGLM-----AEEV 1167
Query: 1595 IKAKEKEV------EKIEQNGLALIQNKKEDVSSI-VMSTLRELGQTWANLDHMVGQLKI 1647
+++EV ++ + + ++ + V ++ ++++EL + W +L + +
Sbjct: 1168 QAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQ 1227
Query: 1648 LLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 1707
LL S + H+ A D+ ++ E +L + + + ++Q LQ E
Sbjct: 1228 LLGSAHEVQRFHRDA-DETKEWIEEKNQAL--------NTDNYGHDLASVQALQRKHEGF 1278
Query: 1708 ERSLQKFGSITNQL------LKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKAL 1761
ER L G N L L + HP E L E+N W++L + A+Q ++
Sbjct: 1279 ERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKR-ADQRKAKLGD 1337
Query: 1762 LQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVK 1821
QR+ + S + N + ++ ++A D T + + + T
Sbjct: 1338 SHDLQRFLSDFRDLMSWI-------NGIRGLVSSDELAKD--VTGAEALLERHQEHRTEI 1388
Query: 1822 DSLFFLHELGEQLKQQVDAS---AASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 1878
D+ + EQ QQ+ A A+ I+ L Q LE+A +++ L L+
Sbjct: 1389 DARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQ-CLEL 1447
Query: 1879 ETFAKSLEALEAWIVEAEEILQGQDPSHSSD-LSTIQERMEE----LKGQMLKFSSMAPD 1933
+ F + E E W+ E L +D S D + + ++ E+ + Q K +++
Sbjct: 1448 QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAF 1507
Query: 1934 LDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL--QSFLLQHQTFLEKCET 1991
D+L G+ D +R + L+R W + +Q E+ SKL L Q +++ E
Sbjct: 1508 ADQLIAAGH-YAKGDISSRRNEVLDR-WRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEA 1565
Query: 1992 WMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ- 2050
W+ +QT + + N Q + + H+ F+AE+ + + +I G L+E+G
Sbjct: 1566 WISEKLQTASDESYKDPTNIQ---SKHQKHQAFEAELHANADRIRGVIDMGNSLIERGAC 1622
Query: 2051 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 2110
D +L L++QWQ +++++ ++ + +Q Q + + WL EV L
Sbjct: 1623 AGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEALL 1681
Query: 2111 MS-----GLGSVPIPLQQARTLFDEVQFKEKVF--LRQQGSYILTVEAGKQLLLSADSGA 2163
S L SV L++ + L ++ E L Q ++T A S
Sbjct: 1682 ASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSA---FDTSQVKDK 1738
Query: 2164 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLL-----KDWEKCEKGIADSLEKLRTFKK 2218
+ +I+ S +L E + F + W K +K + S + R
Sbjct: 1739 RDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTG 1798
Query: 2219 KLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISI----L 2274
Q+L H+ L AE E A+ D +LS DD +I +
Sbjct: 1799 --VQNLRKKHKRLEAE---LAAHEPAIQGVLDTGKKLS------------DDNTIGKEEI 1841
Query: 2275 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN--GD 2332
+R+ W+EL + R Q++ E L E+ F +E W+ + + V+ GD
Sbjct: 1842 QQRLAQFVEHWKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGD 1900
Query: 2333 IL--IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH---ESKASEIEYKLGKVN 2387
L I+ +++K + ++ + + ++ + G+ L K ++ E+ +S+++ GKV+
Sbjct: 1901 TLAAIQGLLKK-HEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVS 1959
Query: 2388 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQ 2447
D L+ AA+ K + A Q + + +W+ E+ L +S +Q
Sbjct: 1960 D-----LEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSS--VQ 2012
Query: 2448 RKLNEQQELQRDIEK-HSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRN 2506
L +Q+ ++ G+A++ L + LL A + +I+ +L +RW
Sbjct: 2013 TLLTKQETFDAGLQAFQQEGIANITALKDQLL-----AAKHVQSKAIEARHASLMKRWSQ 2067
Query: 2507 ICAMSMERRLKIEETWRLWQK-------FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 2559
+ A S R+ K+ E ++K F S F W +++E P + +
Sbjct: 2068 LLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP-----VRCNS 2122
Query: 2560 KEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQ---MVHEGNQRWDNL 2616
EE+K L+ + Q L R+ ++ S + + W NL
Sbjct: 2123 LEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL 2182
Query: 2617 QK-------RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 2669
QK + RR + R+EF ++ W+ E L D
Sbjct: 2183 QKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYL--------LDGSCM 2234
Query: 2670 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 2710
+++ + ++ K ++I A QL +K E L AA+ E
Sbjct: 2235 VEESGTLESQLEATKRKHQEIRAMRSQL-KKIEDLGAAMEE 2274
Score = 114 bits (286), Expect = 1e-24
Identities = 344/1750 (19%), Positives = 691/1750 (39%), Gaps = 219/1750 (12%)
Query: 1551 YENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGL 1610
++ + + L+ W + ++ ++ D ++Q L+ Q E ++A + K+++ G
Sbjct: 49 FQRDAEELEKWIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGN 107
Query: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQ--LKILLKSVLDQWSSH-KVAFDKIN 1667
+I ++ S + + L EL + W L + + +K+L L Q+ + D IN
Sbjct: 108 LMI-SEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIN 166
Query: 1668 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 1727
+ ++ L LE V+V + Q D+ E + + +L++E HP
Sbjct: 167 D-----KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
Query: 1728 PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTN 1787
E + EVN W L + +A Q Q QR+ + S ++++E
Sbjct: 222 E-EELIKTKQDEVNAAWQRL-KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQL-- 277
Query: 1788 ELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA-I 1846
+ +D+A V ++ L + L ++D + L ++L+Q SA +
Sbjct: 278 -MASDDFGRDLAS--VQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQV 334
Query: 1847 QSDQLSLS----QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
+ ++L + + L A A LQ + D+ L +W+ E + ++
Sbjct: 335 KREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD-------LTSWVTEMKALINAD 387
Query: 1903 D-PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKRMQNLNR 1959
+ S + + +R +E KG++ D + L +D+ +++ L+
Sbjct: 388 ELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSE 447
Query: 1960 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQK-----------LAVEIS 2008
ER + L+ + L+ Q + E+C F TEQ L ++
Sbjct: 448 ----------ERAALLELWELRRQQY-EQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496
Query: 2009 GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQW 2068
+ + + HE F+ + ++++ + ++ +L++ D + LLS +
Sbjct: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRR- 555
Query: 2069 QGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLF 2128
+ RA +RR + Q +R+ +++L+ W+ E P LQ
Sbjct: 556 NALHERAMRRRAQLADSFHLQQFFRD-SDELKSWVNEKMKTATDEAYKDPSNLQ------ 608
Query: 2129 DEVQFKEKVF---LRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRL 2185
+VQ K + F L S I +E Q L+ + A+ + A + E+ WK
Sbjct: 609 GKVQ-KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667
Query: 2186 EEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE---LE 2242
E + KL + ++ + + D +L ++ + + D+ ++L Q K+ LE
Sbjct: 668 ELKGIKLREANQQ-QQFNRNVEDI--ELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLE 724
Query: 2243 NAVGSWTDDLTQLSLLKDTL--SAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 2300
V + D + +++ + + A++I ++ E L ++E L + R+Q++
Sbjct: 725 ADVAAHQDRIDGITIQARQFQDAGHFDAENIK---KKQEALVARYEALKEPMVARKQKLA 781
Query: 2301 ERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENK 2357
+ L +F + E W+ + E + ++ D++ + + K + Q EIA +
Sbjct: 782 DSLRLQQLFRDVEDEET-WIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 2358 IQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKN 2417
+ Q G + + H + A +++ KL ++N +W+ L + R + L+++L A QQ +
Sbjct: 841 KAVTQKGNAMVEEGHFA-AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQA-QQYFAD 898
Query: 2418 MSSLRTWLAHIESELAKPIVYDSC---NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLC 2474
+ +W+ E PIV + + + + L + + L D+ + + +
Sbjct: 899 ANEAESWMREKE-----PIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSI------- 946
Query: 2475 EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKI--EETWRLWQKFLDDY 2532
+ L +C QQ D + + + + K E T +
Sbjct: 947 QALREQAQSCR--------QQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLN 998
Query: 2533 SRFEDWLKS--SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELINKQ 2586
S +DW K ++R P++ +KK + Q E L + + L +Q
Sbjct: 999 STNKDWWKVEVNDRQGFVPAAY----------VKKLDPAQSASRENLLEEQGSIALRQEQ 1048
Query: 2587 YRRLARENRTDSACSL--KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSI 2644
R + + SL KQ+ + + +KR + + K F+ RE E +
Sbjct: 1049 IDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ--- 1105
Query: 2645 LVWLTEMDLQLTNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 2703
W+ E + LT+ E ++ + V+ K+ FQ+++ N ++++ I E L +SE
Sbjct: 1106 --WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL--ESEG 1161
Query: 2704 LDAAIIEEELDELRRYCQEVFGRVERYHK--------KLIRLPLPD----------DEHD 2745
L A EE+ +++ QEV+G + R K RL + +E
Sbjct: 1162 LMA----EEVQAVQQ--QEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERW 1215
Query: 2746 LSDRELELEDSAALSDLH----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS 2801
S ++L E S L H +H R AD N Q L ++ G D AS
Sbjct: 1216 RSLQQLAEERSQLLGSAHEVQRFH-RDADETKEWIEEKN------QALNTDNYGHDL-AS 1267
Query: 2802 VDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQ 2861
V + L+ H+ RDL +A+ + S E + + A L + L
Sbjct: 1268 VQA--LQRKHE-GFERDL-AALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSS 1323
Query: 2862 LGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEE 2921
LGK D + ++ + ++ R + +L + G L+ + D V E L+
Sbjct: 1324 LGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVSSDELAKD-VTGAEALLERH 1381
Query: 2922 EESLPGFVNLHSTETQT-AGVIDRWELLQAQALSK----ELRMKQNLQKWQQFNSDLNSI 2976
+E H TE AG +E Q L+ +KQ L Q +DL
Sbjct: 1382 QE--------HRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKA 1433
Query: 2977 WAWLGDTEEELEQLQRLE----------------LSTD-----IQTIELQIKKLKELQKA 3015
W ++ +LQ L+T+ + ++E IKK ++ KA
Sbjct: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKA 1493
Query: 3016 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 3075
++ ++ I ++ + + A D+ R +++ RW R+ + + E R L ++
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTL 1553
Query: 3076 CQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVAS 3135
Q ++ + E + +E S D +Q H++ + EL + R+
Sbjct: 1554 QQFSRDVDEIEAWISEKLQTASDE-----SYKDPTNIQSKHQKHQAFEAELHANADRIRG 1608
Query: 3136 LQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLLLK---EVSRHIKELEKLLDVSSSQQ 3191
+ DM L+ +A K ++ + ++ + L++ E S+ +KE K + ++ +
Sbjct: 1609 VIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK 1668
Query: 3192 DLSSWSSADE 3201
D W S E
Sbjct: 1669 DFDFWLSEVE 1678
Score = 110 bits (276), Expect = 2e-23
Identities = 469/2475 (18%), Positives = 937/2475 (37%), Gaps = 375/2475 (15%)
Query: 135 RETEELRQMIKIRLQNLQDAA-KDMKKFEAELKKLQAALEQAQAT----LTSPEVGRLSL 189
R+ EEL + I+ +LQ D KD + +L+K QA + QA + E G L +
Sbjct: 51 RDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI 110
Query: 190 KE------------QLSHRQH--LLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA 235
E HRQ LL +M K+ Q LR EDV+ + A
Sbjct: 111 SEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEA 170
Query: 236 ALRLQEEASRLQHTAIQQ-------------------CNIMQAAVVQYEQYEQEMKHLQQ 276
+ +E L+H + Q N A ++Q + E+E+ +Q
Sbjct: 171 IVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQ 230
Query: 277 --------LIEGAHREIEDKPVATSNIQELQAQISRH----------------------- 305
++G + + K + +Q +
Sbjct: 231 DEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASV 290
Query: 306 EELAQKIKGYQEQIASLNSKCKMLTMKAKHATML--LTVTEVEGLAEGTEDLDGELLPTP 363
+ L +K +G + +A+L K K L +A L+ T+++ E + E + T
Sbjct: 291 QALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELIT-NWEQIRTL 349
Query: 364 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYY 423
+A + + R L+ + + S V A +N D
Sbjct: 350 AAERHARLNDSYRLQRFLADFRDLT------------------SWVTEMKALINADELAS 391
Query: 424 QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKN---VISEKQR 480
AE L D + H + E + S A L + + ++ V+SE++
Sbjct: 392 DVAGAEAL-LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERA 450
Query: 481 TLYEALE-RQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQA-LMDEILMLQ 538
L E E R+Q+Y+ + ++L ++ + ++ M++ +A L++E L
Sbjct: 451 ALLELWELRRQQYEQCMD--------LQLFYRDTEQV----DNWMSKQEAFLLNEDL--G 496
Query: 539 DEINELQSSLAE-ELVSESCEADPAEQLALQSTLTVLA-------ERMSTIRMKASGKRQ 590
D ++ +++ L + E +S A + AL T L E ++T R +R
Sbjct: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRN 556
Query: 591 LLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLST-KATLDTALSPPKEPMDMEAQLMD 649
L E+ + + LQ++ ++DEL SW+ K D A K+P +++ ++
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY---KDPSNLQGKVQK 613
Query: 650 CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ--RAL 707
Q E+ + L + L+ + + KDE ++ L LLE + +
Sbjct: 614 HQAFEAELSANQSRIDALEKAGQKLI-DVNHYAKDEVAARMNEVISLWKKLLEATELKGI 672
Query: 708 HDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELE--QEL 765
++ N Q E D++L WL + + +S K+L Q L
Sbjct: 673 KLREANQQQQFNRNVE-DIEL----------WLYEV-----EGHLASDDYGKDLTNVQNL 716
Query: 766 AEQKSLLRS-VASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE 824
++ +LL + VA+ + I A DAG E K E + ++E
Sbjct: 717 QKKHALLEADVAAHQDRIDGITIQARQFQDAGH--------FDAENIKKKQE-ALVARYE 767
Query: 825 SLHQEF-STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLN 883
+L + + KQKL ++ Q+ + + + P+ +D V +LL
Sbjct: 768 ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQ 827
Query: 884 QAFEEVS---------SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPE 934
E++ +Q G A + H + V A L+ E L + +
Sbjct: 828 ALQAEIAGHEPRIKAVTQKGNAMVEEGHFAA---EDVKAKLHELNQKWEALKAKASQRRQ 884
Query: 935 ETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDS 994
+ E L Q+ A + S +K + S + ++ D+ + + L+ LS S
Sbjct: 885 DLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGS 944
Query: 995 VVNQRCHQMKERLQQILNFQNDL-KVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQA 1053
+ Q + QQ+ ++ K L +L D +++ ++
Sbjct: 945 SIQALREQAQSCRQQVAPTDDETGKELVLALYD------------YQEKSPREVT----- 987
Query: 1054 EDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKS 1113
+K+ D + D +VE Q + + +S +NL L+
Sbjct: 988 ---MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA-----YVKKLDPAQSASRENL-LEE 1038
Query: 1114 QYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFR 1173
Q AL+ +T K AG + + EE+ L + E +G+ E +
Sbjct: 1039 QGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGM------LEKSCK 1092
Query: 1174 KIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELS------R 1227
K + F E Q + + + A L + + G +LE + D+ Q++L +
Sbjct: 1093 KFMLFREANELQ---QWINEKEAALT-SEEVGADLEQVEVLQKKFDDFQKDLKANESRLK 1148
Query: 1228 QLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 1287
+ V + S GL+ E E + + + +Y + +E K + ++ +++
Sbjct: 1149 DINKVAEDLESEGLMAE-EVQAVQQQEVYGMMPR--DETDSKTASPWKSARLMVHTVATF 1205
Query: 1288 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ 1347
+ + +L E W S ++++E +L R+ ++ + W++ L
Sbjct: 1206 N---SIKELNERWRS-LQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALN---- 1257
Query: 1348 QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSR 1407
+ +L V+ F +++ A +S+ T +L++ L+ + +
Sbjct: 1258 -TDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTE 1316
Query: 1408 IDSQWTDLLTNIPAVQEKL---HQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNS 1464
++ W+ L + KL H LQ R ++MSWI+ + ++ DE K+
Sbjct: 1317 LNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFR----DLMSWINGIRGLVSSDE-LAKDV 1371
Query: 1465 IGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQD--VESKRSDKTDFAEQLGA 1522
G +A+ L++++ + +I+ + T Q Q+ + + K D +Q A
Sbjct: 1372 TGAEAL---LERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA 1428
Query: 1523 -MNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASV 1581
+ K+W ++ +L+ LE + + + + W +E L + + SV
Sbjct: 1429 DLEKAW-------VQRRMMLDQCLEL-QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
Query: 1582 QNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHM 1641
+ +K +D + I +E+++ ++ LI A +
Sbjct: 1481 EALIKKHEDFDKAINVQEEKIAALQAFADQLI----------------------AAGHYA 1518
Query: 1642 VGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQ 1701
G + VLD+W K + S L E++ +L +F +EA + LQ
Sbjct: 1519 KGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQ-TLQQFSRDVDEIEAWISE--KLQTAS 1575
Query: 1702 DDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIA----EQLQS 1757
D+ K ++Q E H + ++ V N+L+E A E
Sbjct: 1576 DESYKDPTNIQSKHQKHQAFEAELHANA-----DRIRGVIDMGNSLIERGACAGSEDAVK 1630
Query: 1758 SK--ALLQLWQRYKDYSKQCASTVQQQEDRTN--------ELLKAATNKDIADDEVATWI 1807
++ AL WQ S + + +++ + N + + +A ++ +
Sbjct: 1631 ARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDL 1690
Query: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA-SAASAIQSDQLSLSQHLCALEQALCK 1866
N+LLK ++ + + + L Q D+ +SA + Q+ + K
Sbjct: 1691 ASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIK 1750
Query: 1867 QQTSLQAGVLD----YETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKG 1922
+ + L+ F + ++ E+WI E + ++ +D + DL+ +Q ++ K
Sbjct: 1751 SMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSED--YGRDLTGVQNLRKKHKR 1808
Query: 1923 QMLKFSSMAPDLDRLNELGYRLP----LNDKEIK-RMQNLNRHWSLISSQTTERFSKLQS 1977
+ ++ P + + + G +L + +EI+ R+ HW + R +L+
Sbjct: 1809 LEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1868
Query: 1978 FLLQHQTFL---EKCETWMEFLVQTEQKLAVEISGNYQHLLEQ----QRAHELFQAEMFS 2030
L ++Q F+ E+ E W+ +K+ + S +Y L + HE F+ +
Sbjct: 1869 SL-EYQQFVANVEEEEAWIN------EKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTV 1921
Query: 2031 RQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQ 2090
+ ++ + +GQ L+++ + + + K+ L+ + + + A QR+ +D +
Sbjct: 1922 HKDRVNDVCTNGQDLIKKNNHHE-ENISSKMKGLNGKVSDLEKAAAQRKAKLDEN-SAFL 1979
Query: 2091 RYREMAEKLRKWLVEV-SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTV 2149
++ A+ + W+ E + L G L +TL + + + Q I +
Sbjct: 1980 QFNWKADVVESWIGEKENSLKTDDYGR---DLSSVQTLLTKQETFDAGLQAFQQEGIANI 2036
Query: 2150 EAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADS 2209
A K LL+A A++A A + ++W +KKKL + K E
Sbjct: 2037 TALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVE------ 2090
Query: 2210 LEKLRTFKKKLS--QSLPDHHEELHAEQMRCKELE-------------NAVGSWTDDLTQ 2254
+ TF KK S S ++ EE + +RC LE +++ S D Q
Sbjct: 2091 -DLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQ 2149
Query: 2255 LSLLKDTLSAYISADD------ISILNERVELLQR--QWEELCHQLSLRRQQIGERLNEW 2306
L+ L + ++ A + + L E LQ+ + EL Q RRQ+ ++L +
Sbjct: 2150 LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQ- 2208
Query: 2307 AVFSEKNKELCEWLTQMESKVSQNGDILIEE------MIEKLKKDYQEEIAIAQENKIQL 2360
F++ +W+ + + + +G ++EE +E K+ +QE A+ + K ++
Sbjct: 2209 -EFAQHANAFHQWIQETRTYL-LDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLK-KI 2265
Query: 2361 QQMGERLAKA--------SHESKASEIEY-KLGKVNDRWQHLLD-LIAAR------VKKL 2404
+ +G + +A H + ++ +L ++ R QH L+ I AR + L
Sbjct: 2266 EDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEAL 2325
Query: 2405 KETLVAVQQLDKNMS 2419
KE + + DK+ S
Sbjct: 2326 KEFSMMFKHFDKDKS 2340
Score = 100 bits (249), Expect = 2e-20
Identities = 417/2236 (18%), Positives = 860/2236 (38%), Gaps = 311/2236 (13%)
Query: 27 KLTELHQQ---TIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 83
+L ELH+Q + + + KL QA L +Y E ++ WI + + ++
Sbjct: 123 RLMELHRQWELLLEKMREKGIKLLQAQK-LVQYLRECEDVMDWINDKEAIV-------TS 174
Query: 84 SQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQM 143
+L + + L ++ +E +++ A E++ +++Q A+L +E ++
Sbjct: 175 EELGQDLEHVEVLQKKFEEFQTDMAAHEERVN---------EVNQFAAKLIQEQHPEEEL 225
Query: 144 IKIRLQNLQDA-----------------AKDMKKFEAELKKLQAALEQAQATLTSPEVGR 186
IK + + A A ++++F ++ + + +++ + + S + GR
Sbjct: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR 285
Query: 187 LSLKEQLSHRQH--LLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEE-- 242
Q R+H L ++ +L+ KV+A LC A R+ + S PL ++++ E
Sbjct: 286 DLASVQALLRKHEGLERDLAALEDKVKA--LCAEADRLQQ----SHPLSATQIQVKREEL 339
Query: 243 ---------ASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS 293
+ +H + +Q + + + ++ LI S
Sbjct: 340 ITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE--------LAS 391
Query: 294 NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT----MLLTVTEVEGLA 349
++ +A + RH+E +I +++ S + + L +A+ LTV E A
Sbjct: 392 DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
Query: 350 EGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPV 409
L+ L + + R + + N ++ +
Sbjct: 452 L----LELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG--------DSL 499
Query: 410 ANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWE 469
+ +A + + + ++LSA+ + A + Y +E AT + L R
Sbjct: 500 DSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHY--AMEDVATRRDALLSRR-N 556
Query: 470 TLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQA 529
L ++ L ++ QQ ++DS + S E ++ E+ + + + ++ +HQA
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
Query: 530 LMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKR 589
E+ Q I+ L+ + ++L+ + A + +++ + + +K
Sbjct: 617 FEAELSANQSRIDALEKA-GQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGI--- 672
Query: 590 QLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD 649
+L E Q+Q R ++++ WL + L + D L +
Sbjct: 673 ---------KLREANQQQQFNR---NVEDIELWLYEVEGHLASD--------DYGKDLTN 712
Query: 650 CQNMLVEIEQKVVALSELSVHNENLLLEG---------------KAHTKDEAEQLAGKLR 694
QN+ QK AL E V ++G + K + E L +
Sbjct: 713 VQNL-----QKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYE 767
Query: 695 RLKGSLLELQRALHDKQLNMQGTAQEKEESDV----------------DLTATQSPGVQE 738
LK ++ ++ L D L +Q ++ E+ + DL Q+ +
Sbjct: 768 ALKEPMVARKQKLAD-SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKH 826
Query: 739 WLAQARTTWTQQRQSSLQQQ---------------KELEQELAEQKSLLRSVAS-RGEEI 782
QA + R ++ Q+ K EL ++ L++ AS R +++
Sbjct: 827 QALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDL 886
Query: 783 LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ-----MRMKWESLHQEFSTKQKLL 837
A + DA E + ++ + G +D+ + K E+L + S +
Sbjct: 887 EDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSI 946
Query: 838 QNVLEQEQEQVLYSRPNRLLSGVPL------YKGDVP---TQDKSAVTSLLDGLNQAF-- 886
Q + EQ Q P +G L Y+ P T K + +LL+ N+ +
Sbjct: 947 QALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWK 1006
Query: 887 EEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEIL 946
EV+ + G + +KL SA+ L +EE+ + AL E+ + NQ +
Sbjct: 1007 VEVNDRQGFVPAAYV---KKLDPAQSASRENL--LEEQ--GSIALRQEQID----NQTRI 1055
Query: 947 AKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLG--CLLGRLSLLDSVVNQR----- 999
K+ +S M + + L+ + ++E + L + L +N++
Sbjct: 1056 TKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALT 1115
Query: 1000 -------CHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQP--VAEQIEAI 1050
Q++ ++ +FQ DLK + L D + K+A E +AE+++A+
Sbjct: 1116 SEEVGADLEQVEVLQKKFDDFQKDLKANESRLKD-----INKVAEDLESEGLMAEEVQAV 1170
Query: 1051 QQAE-DGL---KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLN 1106
QQ E G+ E D+ + + + + +L + + L + R +
Sbjct: 1171 QQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEER----S 1226
Query: 1107 QNLTLKSQYERALQDLADLLETGQEK-MAGDQKIIVSSKEEIQQLLDKHKEYFQGL---- 1161
Q L + +R +D + E +EK A + +Q L KH+ + + L
Sbjct: 1227 QLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALG 1286
Query: 1162 ESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLD 1219
+ L ET R I S E + TEL S++ KRA +R +L + L
Sbjct: 1287 DKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFL- 1345
Query: 1220 EDQQELSRQLEVVESSIPSVGLVEE--NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 1277
D ++L + + + S L ++ + L++R +Q ++ ++ G
Sbjct: 1346 SDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER---HQEHRTEIDARAGTFQAFEQFG 1402
Query: 1278 KRLL---------ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSES 1328
++LL I L+ + L + W+ + + LE L H Q+E
Sbjct: 1403 QQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQ---CLELQLFHRDCEQAE- 1458
Query: 1329 ADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGN 1388
+W+ + + L + L+ V + +F K ++ Q +++ + +
Sbjct: 1459 ----NWMAAREAFL-----NTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFAD 1509
Query: 1389 QLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWIS 1448
QL+ + S + + +W L + + KL + Q + SR + E+ +WIS
Sbjct: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRD-VDEIEAWIS 1568
Query: 1449 LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 1508
E + +++ K+ ++ H QK++ F+ +++ + + V+ + + +E
Sbjct: 1569 --EKLQTASDESYKDPTNIQSKH---QKHQAFEAELHANADRI----RGVIDMGNSLIER 1619
Query: 1509 KRSDKTDFA--EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 1566
++ A +L A+ WQ L EK Q L+ + ++ W E
Sbjct: 1620 GACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKE-ANKQQNFNTGIKDFDFWLSEVE 1678
Query: 1567 KRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMS 1626
L + D ASV N LK Q LE I A E ++ + +L+ + D S V
Sbjct: 1679 ALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQ-VKD 1737
Query: 1627 TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKV-----AFDKINSYLMEARYSLSRFR 1681
+ + + M + L SH++ D S++ E +
Sbjct: 1738 KRDTINGRFQKIKSMAASRRAKLN------ESHRLHQFFRDMDDEESWIKEK-------K 1784
Query: 1682 LLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVN 1741
LL GS E + +QNL+ ++ E L +L + +++ T +E+
Sbjct: 1785 LLVGS-EDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVL-DTGKKLSDDNTIGKEEIQ 1842
Query: 1742 MRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADD 1801
R +E E Q + A Q + +Y +Q + V+++E NE + ++D D
Sbjct: 1843 QRLAQFVEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASEDYGDT 1901
Query: 1802 EVA-TWIQDCNDLLKGLGTV-KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859
A + ++ + TV KD + + G+ L ++ + + I S L+ +
Sbjct: 1902 LAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSD 1960
Query: 1860 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEE 1919
LE+A +++ L + F + +E+WI E E L+ D + DLS++Q + +
Sbjct: 1961 LEKAAAQRKAKLDENSA-FLQFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTK 2017
Query: 1920 LKG-----QMLKFSSMAPDLDRLNELGYRLPLNDKEIK-RMQNLNRHWSLISSQTTERFS 1973
+ Q + +A ++L + K I+ R +L + WS + + + R
Sbjct: 2018 QETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKK 2077
Query: 1974 KL---QSFLLQHQ----TFLEKCETWMEFLVQTEQKLAVEISGN-YQHLLEQQRAHELFQ 2025
KL QS + + TF +K + + E+ L + N + + + AH+ F+
Sbjct: 2078 KLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFR 2137
Query: 2026 AEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQ 2085
+ + S Q + + + R ++ +V + L W+ + + ++R + +
Sbjct: 2138 SSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKER----ELE 2192
Query: 2086 IRQWQRYREMAEKLRK 2101
+++ QR +E +KLR+
Sbjct: 2193 LQKEQRRQEENDKLRQ 2208
Score = 88.6 bits (218), Expect = 9e-17
Identities = 222/1185 (18%), Positives = 460/1185 (38%), Gaps = 147/1185 (12%)
Query: 2088 QWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 2147
++Q ++ AE+L KW+ E + P LQ + Q E G+ +
Sbjct: 45 RFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGK---LQKHQAFEAEVQANSGAIVK 101
Query: 2148 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEE------QKKKLAFLLKDWEK 2201
E G L++S A ++ L E+ +W+ ++ E Q +KL L++ E
Sbjct: 102 LDETGN-LMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED 160
Query: 2202 CEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDT 2261
I D E + T S+ L E + Q + +E + + + + + +++
Sbjct: 161 VMDWINDK-EAIVT-----SEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAK 214
Query: 2262 LSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLT 2321
L ++ ++ + + + W+ L L+L+RQ E F+ E W+
Sbjct: 215 LIQEQHPEE-ELIKTKQDEVNAAWQRL-KGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
Query: 2322 QMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE 2378
+ E ++ + D+ + + + + + ++A ++ L +RL + SH A++
Sbjct: 273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ-SHPLSATQ 331
Query: 2379 IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-AKPIV 2437
I+ K ++ W+ + L A R +L ++ +Q+ + L +W+ +++ + A +
Sbjct: 332 IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELA 390
Query: 2438 YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 2497
D +E + L+ QE + +I+ H S + LL A D +++
Sbjct: 391 SDVAGAEAL---LDRHQEHKGEIDAHEDSFKSADESGQALL-----AAGHYASDEVREKL 442
Query: 2498 RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 2557
L + + RR + E+ L Q F D + ++W+ S + G
Sbjct: 443 TVLSEERAALLELWELRRQQYEQCMDL-QLFYRDTEQVDNWM-SKQEAFLLNEDLGDSLD 500
Query: 2558 VAKEELKKFEAFQRQV---HECLTQLE------LINKQYRRLARENRTDSACSLKQMVHE 2608
+ LKK E F++ + E +T L+ + N Y R D+ S + +HE
Sbjct: 501 SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHE 560
Query: 2609 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQA 2668
R ++ + L+ F +E ++ W+ E T+ + ++Q
Sbjct: 561 RAMR----RRAQLADSFHLQQFFRDSDELKS-------WVNEKMKTATDEAYKDPSNLQG 609
Query: 2669 KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFG--- 2725
K+++ +AF+ E+S N ++I+ + G++LI+ + DE+ EV
Sbjct: 610 KVQKHQAFEAELSANQSRIDALEKAGQKLID--------VNHYAKDEVAARMNEVISLWK 661
Query: 2726 -RVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLS 2784
+E K I+L + + + ++E L ++ H S D NL
Sbjct: 662 KLLEATELKGIKLREANQQQQFNRNVEDIE--LWLYEVEGHLASDDYGKDLTNVQNLQKK 719
Query: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR-DLESAMSRALPSEDEEGQDDKDFYLR 2843
A + +D +D I ++ D D E+ + +E + L+
Sbjct: 720 HALLEADVAAHQD---RIDGITIQARQFQDAGHFDAENIKKK------QEALVARYEALK 770
Query: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL---DTSYKGYMKL 2900
+ A +++QL + ++D I++ E I S T G +L K + L
Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAAS-TNRGKDLIGVQNLLKKHQAL 829
Query: 2901 LGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK 2960
E + +K + K E G + + + +WE L+A+A + ++
Sbjct: 830 QAEIAGHEPRIKAVTQKGNAMVEE--GHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
Query: 2961 QNLQKWQQFNSDLNSIWAWL------------GDTEEELEQLQRLE--LSTDIQTIELQI 3006
+LQ QQ+ +D N +W+ G E+ E L + L +D+ I
Sbjct: 888 DSLQA-QQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSI 946
Query: 3007 KKLKELQKAVDHR---------KAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 3057
+ L+E ++ + K ++L++ + + + + D+ L+ N W +
Sbjct: 947 QALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWK 1006
Query: 3058 V-------------CSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
V L+ + ++ L++ QG + L E ID +
Sbjct: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG------SIALRQEQIDNQTR------ 1054
Query: 3105 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE---------- 3154
+A + KQ+ ++ H LLE + + + SC+ + + L+
Sbjct: 1055 ITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
Query: 3155 AKEKVHVIGNRLKLLLKEVSRHIKELE----KLLDVSSSQQDLSS 3195
E+V ++++L K+ K+L+ +L D++ +DL S
Sbjct: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES 1159
Score = 85.1 bits (209), Expect = 1e-15
Identities = 198/1069 (18%), Positives = 423/1069 (39%), Gaps = 140/1069 (13%)
Query: 2187 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVG 2246
E + F +D E+ EK I + L+ K +L ++ A + + A+
Sbjct: 41 EDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIV 100
Query: 2247 SWTDDLTQLSLLKDTLSAYISADDISILNERVELLQ--RQWEELCHQLS------LRRQQ 2298
L +T + IS + R L++ RQWE L ++ L+ Q+
Sbjct: 101 K----------LDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQK 150
Query: 2299 IGERLNEWAVFSEKNKELCEWLTQMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQE 2355
+ + L E +++ +W+ E+ V+ D+ E+++K +++Q ++A +E
Sbjct: 151 LVQYLREC-------EDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
Query: 2356 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 2415
++ Q +L + H + I+ K +VN WQ L L R KL VQ+ +
Sbjct: 204 RVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAAWQRLKGLALQRQGKLFGA-AEVQRFN 261
Query: 2416 KNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE 2475
+++ +W+ E +A S++ R L Q L R E +A++ + +
Sbjct: 262 RDVDETISWIKEKEQLMA---------SDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
Query: 2476 VLLHDCDACATD--AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYS 2533
L + D IQ L W I ++ ER ++ +++RL Q+FL D+
Sbjct: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL-QRFLADFR 371
Query: 2534 RFEDWLKSSERTAAFPSSSGVIYTVAKEE--LKKFEAFQRQVHECLTQLELINKQYRRLA 2591
W+ + A ++ + VA E L + + + ++ A
Sbjct: 372 DLTSWVTEMK---ALINADELASDVAGAEALLDRHQEHKGEID----------------A 412
Query: 2592 RENRTDSACSLKQ-MVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARDSILV 2646
E+ SA Q ++ G+ D +++++T + L+ + +R+++E D L
Sbjct: 413 HEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLF 472
Query: 2647 ---------WLTEMDLQLTNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQ 2696
W+++ + L N + D V+A +K+ + F++ +S KI + +
Sbjct: 473 YRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATK 532
Query: 2697 LIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDS 2756
LI+ + ++++ + R H++ +R R +L DS
Sbjct: 533 LIQNNH--------YAMEDVATRRDALLSRRNALHERAMR------------RRAQLADS 572
Query: 2757 AALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS 2816
L R +D L S + + + + + + + + E +
Sbjct: 573 FHLQQFF---RDSDELKS-WVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
Query: 2817 RDLESAMSRALP----SEDEEGQDDKDFY-----LRGAVGLSGDHSALESQIRQLGKALD 2867
LE A + + ++DE + L A L G +Q +Q + ++
Sbjct: 629 DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVE 688
Query: 2868 DSRFQIQQTENIIRSKTPTGPEL---DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 2924
D + + E + S G +L K + L + ++ D + + + ++ +++
Sbjct: 689 DIELWLYEVEGHLASDD-YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
Query: 2925 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
G + + + + ++ R+E L+ ++++ ++ +L+ Q F D+ W+ + E
Sbjct: 748 --GHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFR-DVEDEETWIREKE 804
Query: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 3044
R D+ ++ +KK + LQ + + I ++ + + D+
Sbjct: 805 PIAASTNR---GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDV 861
Query: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
+ +L ++N +W+ + + + R L+D+L Q F + + M E PI
Sbjct: 862 KAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREK--------EPIV 913
Query: 3105 SNLDAEILQDHHKQLMQIKHELLESQL-----RVASLQDMSCQLLVNAEGTDCLEAKEKV 3159
+ D +D + L++ KHE L S L + +L++ + TD KE V
Sbjct: 914 GSTDYGKDEDSAEALLK-KHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELV 972
Query: 3160 HVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSV 3208
+ + + +EV+ +K+ + L ++S+ +D W + D G V
Sbjct: 973 LALYDYQEKSPREVT--MKKGDILTLLNSTNKD---WWKVEVNDRQGFV 1016
Score = 79.7 bits (195), Expect = 4e-14
Identities = 333/1826 (18%), Positives = 692/1826 (37%), Gaps = 283/1826 (15%)
Query: 3 LDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLEL 62
L+ A QK ++ N +A ++ ++ L ++ + E + KL +A + +++N +E
Sbjct: 631 LEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVED 689
Query: 63 ILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV-- 120
I W+ + + + ++ H L + ++ +T + +
Sbjct: 690 IELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGH 749
Query: 121 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180
+ E + ++ L E L++ + R Q L D+ + + F +++ + + + +
Sbjct: 750 FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFR-DVEDEETWIREKEPIAA 808
Query: 181 SPEVGR--LSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALR 238
S G+ + ++ L Q L +E+ +P+++AV +A+ + E A+
Sbjct: 809 STNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAM-VEEGHFAA--------- 858
Query: 239 LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI----EDKPVATS- 293
E+ H Q+ ++A Q Q ++ QQ A+ E +P+ S
Sbjct: 859 --EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
Query: 294 ----NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLA 349
+ +A + +HE L + Y I +L + A+ + T+
Sbjct: 917 DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQ-------AQSCRQQVAPTD----D 965
Query: 350 EGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR----S 405
E ++L L P V M G TLL+ ++ + N PA
Sbjct: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025
Query: 406 PSPVANTDASVNQD----IAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 461
P+ A+ + + + + Q + R+ +A + +E Y LE K
Sbjct: 1026 PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRK- 1084
Query: 462 GDLQRSWET---------LKNVISEKQRTL--------YEALERQQKYQDSLQSISTKME 504
G L++S + L+ I+EK+ L E +E QK D Q
Sbjct: 1085 GMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK------ 1138
Query: 505 AIELKLSESPEPGRSPESQMAEHQALM-DEILMLQDEINELQSSLAEELVSESCEADPAE 563
+LK +ES + ++ E + LM +E+ +Q + E+ + + ++S A P +
Sbjct: 1139 --DLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ--EVYGMMPRD-ETDSKTASPWK 1193
Query: 564 QLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWL 623
L + + + +QL EE+ QL E +QR+ +ADE W+
Sbjct: 1194 SARLMVHTVATFNSIKELNERWRSLQQLAEER--SQLLGSAHE--VQRFHRDADETKEWI 1249
Query: 624 LSTKATLDT-----------ALSPPKEPMDME-AQLMDCQNMLVEIEQKVVALSELSVHN 671
L+T AL E + + A L D N L E ++++ S +
Sbjct: 1250 EEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAED 1309
Query: 672 ENLLLEGKAHTKDEAEQLAGK---LRRLK-GSLLELQRALHDKQLNMQGTAQEKEESDVD 727
L+ K ++A GK R+ K G +LQR L D + M + D
Sbjct: 1310 ----LQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSD 1365
Query: 728 LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHS 787
A G ++ L++ +E E+ + ++ G+++L
Sbjct: 1366 ELAKDVTGA---------------EALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
Query: 788 AAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRM-----------------KWESLHQEF 830
A S + +K D+L QE + EK+ + +M + W + + F
Sbjct: 1411 YA--SPEIKQKLDILDQERA-DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF 1467
Query: 831 ---STKQKLLQNV---------------LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK 872
K L +V +++E+ L + ++L++ KGD+ ++
Sbjct: 1468 LNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR- 1526
Query: 873 SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL 932
EV + K Q I KL + + D E +++ L
Sbjct: 1527 --------------NEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ 1572
Query: 933 PEETETCLFNQEILAKDIKEMSEEMDKNKNL--------FSQAFPENG---DNRDVIEDT 981
E+ I +K K + E + + N + E G + D ++
Sbjct: 1573 TASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKAR 1632
Query: 982 LGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQ 1041
L L + L ++ ++KE +Q NF +K L++ + ++ +
Sbjct: 1633 LAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEALLASEDYGKDLA 1691
Query: 1042 PVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD-------EL 1094
V ++ Q E + + + +L + D L S + S+++D D ++
Sbjct: 1692 SVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTS--SAFDTSQVKDKRDTINGRFQKI 1749
Query: 1095 MMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE------EIQ 1148
+ SRR+ LN++ L Q+ R + D +E ++K++V S++ +Q
Sbjct: 1750 KSMAASRRAKLNESHRL-HQFFRDMDD--------EESWIKEKKLLVGSEDYGRDLTGVQ 1800
Query: 1149 QLLDKHKEYFQGLESH------MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAH 1202
L KHK L +H ++ T + ++ Q + + + + A
Sbjct: 1801 NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA 1860
Query: 1203 KRGVELEYILETW---SHLDEDQQELSRQLEVVES-----SIPSV-GLVEENE------- 1246
RG LE LE ++++E++ ++ ++ +V S ++ ++ GL++++E
Sbjct: 1861 ARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT 1920
Query: 1247 ---DRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSN 1303
DR+ D T Q L N ++ IS L +++ L +
Sbjct: 1921 VHKDRVNDVCTNGQDLIKKNNHHEEN------------ISSKMKGLNGKVSDLEKAAAQR 1968
Query: 1304 TNKMSKELHRLETILKHWTRYQSESADLIH-WLQSAKDRLEFWTQQSVTVPQELEMVRDH 1362
K+ + L+ +W AD++ W+ ++ L ++ ++L V+
Sbjct: 1969 KAKLDENSAFLQF---NW------KADVVESWIGEKENSL-----KTDDYGRDLSSVQTL 2014
Query: 1363 LNAFLEFSKEVDA-QSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPA 1421
L F + A Q +++ + +QLL K V + + + + + +W+ LL N A
Sbjct: 2015 LTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2074
Query: 1422 VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHE---YLQKYK 1478
++KL + Q S + + E+++ + + ++ E + +
Sbjct: 2075 RKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHD 2134
Query: 1479 GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEK- 1537
F+ ++ Q + + + QI S V S + T F + A+ ++W+ LQ ++ E+
Sbjct: 2135 AFRSSLSSAQADFNQLAELDRQIKSFRVAS--NPYTWFT--MEALEETWRNLQKIIKERE 2190
Query: 1538 --IQLLEGLLES----WSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQD 1590
+Q + E E+ + W ET+ L + + ++++ L+ +
Sbjct: 2191 LELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKR 2250
Query: 1591 LEDLIKAKEKEVEKIEQNGLA-----LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 1645
I+A +++KIE G A ++ NK + S++ L Q W LD + ++
Sbjct: 2251 KHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTV------GLAQQWDQLDQLGMRM 2304
Query: 1646 KILLKSVLDQWSSHKVAFDKINSYLM 1671
+ L+ + ++ V + + + M
Sbjct: 2305 QHNLEQQIQARNTTGVTEEALKEFSM 2330
Score = 51.2 bits (121), Expect = 2e-05
Identities = 129/721 (17%), Positives = 287/721 (39%), Gaps = 55/721 (7%)
Query: 2491 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPS 2550
+ IQ+ + + R+ +S RR K+E+++R +Q F D E W++ + A+ +
Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 2551 SSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 2610
T + +L+K +AF+ +V + +++ + E S +++ + E +
Sbjct: 72 YKDP--TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE-TIRTRLMELH 128
Query: 2611 QRWDNLQKRVTSILRRLKHFIGQR-EEFETARDSILVWLTEMDLQLTNIEHFSECD-VQA 2668
++W+ L +++ + +K Q+ ++ + ++ W+ + + +T+ E + + V+
Sbjct: 129 RQWELLLEKMRE--KGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEV 186
Query: 2669 KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVE 2728
K+ + FQ +++ + ++ ++ +LI++ P + +I+ + DE+ Q + G
Sbjct: 187 LQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLKGLAL 245
Query: 2729 RYHKKLIRLP----LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLS 2784
+ KL D + E E A D S +LL L+
Sbjct: 246 QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 2785 LAQP------LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDK 2838
+ ++R + P S I ++ + +L + E R L +E +D
Sbjct: 306 ALEDKVKALCAEADRLQQSHPLSATQIQVKRE---ELITNWEQI--RTLAAERHARLND- 359
Query: 2839 DFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYM 2898
+ L+ + D ++ ++++ L A D+ + E ++ E+D +
Sbjct: 360 SYRLQRFLADFRDLTSWVTEMKALINA-DELASDVAGAEALLDRHQEHKGEIDAHEDSFK 418
Query: 2899 KLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 2958
S ++ H +E L + A +++ WEL + Q
Sbjct: 419 ----SADESGQALLAAGHYASDEVRE-----KLTVLSEERAALLELWELRRQQ------- 462
Query: 2959 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDH 3018
+ Q F D + W+ E L +L + ++E +KK ++ +K++
Sbjct: 463 -YEQCMDLQLFYRDTEQVDNWMSKQE---AFLLNEDLGDSLDSVEALLKKHEDFEKSLSA 518
Query: 3019 RKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG 3078
++ I +++ + + Q + D+ R + R + + R L D+ Q
Sbjct: 519 QEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQF 578
Query: 3079 FHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQD 3138
F + + E + +E SNL ++ Q H + EL +Q R+ +L+
Sbjct: 579 FRDSDELKSWVNEKMKTATDEAYKDPSNLQGKV-QKH----QAFEAELSANQSRIDALEK 633
Query: 3139 MSCQLL-VNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK--ELEKLLDVSSSQQDLSS 3195
+L+ VN D + A+ VI KLL + IK E + + + +D+
Sbjct: 634 AGQKLIDVNHYAKDEVAARMN-EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIEL 692
Query: 3196 W 3196
W
Sbjct: 693 W 693
>gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]
Length = 2341
Score = 161 bits (408), Expect = 9e-39
Identities = 310/1756 (17%), Positives = 660/1756 (37%), Gaps = 233/1756 (13%)
Query: 986 LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAE 1045
L LS +V Q+ +++ +Q + L ++ SL +I Q A + ++ A
Sbjct: 6 LRNLSYKKAVRRQKL--LEQSIQSAQETEKSLHLIQESLT---FIDKQLAAYIADKVDAA 60
Query: 1046 QI-EAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSG 1104
Q+ + Q+ + L + + E+K+ + Q + ++ Q ++ M +
Sbjct: 61 QMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKP 120
Query: 1105 LNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH 1164
N +E+ LQ+ +L+ + + + V +E +Q L+ ++ L
Sbjct: 121 AN--------FEQRLQESKMILDEVKMHLPALETKSVE-QEVVQSQLNHCVNLYKSLSEV 171
Query: 1165 MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV-------ELEYILETWSH 1217
E + + +K+T+ EL + +A+ ++ G +LE L+
Sbjct: 172 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 231
Query: 1218 LDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 1277
+ ++ L+ L + + VE L + + + + + + L + + G
Sbjct: 232 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 291
Query: 1278 KRLLISISCSD--LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 1335
+ L + + +E +L+ L W++ T++ + L+ L KH + + W+
Sbjct: 292 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 351
Query: 1336 QSAKDRLEFWTQQSVTVPQELEMVRDHLNAFL-EFSKEVDAQSSLKSSVLST-GNQLLRL 1393
A L+ + PQ+ E V L A L + +VD+ +++++ G+ +L
Sbjct: 352 IQADTLLD---ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 408
Query: 1394 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 1453
+ + L + I + +IP + + + KL +E+ ++L E
Sbjct: 409 VEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKL-LEPLEAEIQQGVNLKEED 467
Query: 1454 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 1513
KD N + E LQ+ N +Q D + ++I Q +++K +
Sbjct: 468 FNKD----MNEDNEGTVKELLQR------GDNLQQRITDERKREEIKIKQQLLQTKHNAL 517
Query: 1514 TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 1573
D Q + + LE + W +Y+ L + EK+L
Sbjct: 518 KDLRSQ----------------RRKKALE-ISHQWYQYKRQADDLLKCLDDIEKKLASLP 560
Query: 1574 RIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQ 1633
D+ ++ ++ Q ++ + A ++ E + ++G A+ V T +L +
Sbjct: 561 EPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM----------AVEPTQIQLSK 610
Query: 1634 TWANLDHMVGQLKIL----LKSVLDQW----------------SSHKVAFDKINSYLMEA 1673
W ++ Q + L + +V ++ S++ ++ L+E
Sbjct: 611 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
Query: 1674 RYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETL 1733
L+ L E + Q ++L+N++D L++ + S L+ P L
Sbjct: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 730
Query: 1734 TNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAA 1793
L +++ +W + + ++ ++ W+R+ K Q + L+
Sbjct: 731 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK----IFNQWLTEAEQFLRKT 786
Query: 1794 TNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSL 1853
+ + W +L G+G + + L+ GE++ QQ + AS +Q SL
Sbjct: 787 QIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 844
Query: 1854 SQHLCALEQALCKQQTSLQAGVLDYET----FAKSLEALEAWIVEAEEILQGQDPSHSSD 1909
+ Q +CKQ + + + + + F + L W+ EA+ I P
Sbjct: 845 NLRW----QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI--ASIPLEPGK 898
Query: 1910 LSTIQERMEELKGQMLKFSSMAPDLDRLNELG----YRLPLNDKEIKRMQN----LNRHW 1961
++E++E++K + + L +LNE G P++ +E +++N N W
Sbjct: 899 EQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 958
Query: 1962 SLISSQTTERFSKLQSFLLQHQTFLEKCETWME-------FLVQTEQKLAVEISGNYQHL 2014
+S E+ ++++ + +K E E +L +L + N +
Sbjct: 959 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 1018
Query: 2015 LEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRR 2074
+ Q QA +Q + I+ GQ L ++ KL LS++W+ V R
Sbjct: 1019 FDVQETEIAVQA----KQPDVEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRL 1072
Query: 2075 AQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK 2134
Q+ R L L + P + V P+ T +
Sbjct: 1073 LQE--------------LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK---- 1114
Query: 2135 EKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF 2194
L S +L V A LA+ W
Sbjct: 1115 ----LEMPSSLMLEVPA-------------------LADFNRAWTE-------------- 1137
Query: 2195 LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQ 2254
L DW L+++ ++ + L D +E + ++ ++LE + +T
Sbjct: 1138 -LTDW-------LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA 1189
Query: 2255 LSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK 2314
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +
Sbjct: 1190 AQNLKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKE 1246
Query: 2315 ELCEWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKA 2370
E + L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 1247 EAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 1306
Query: 2371 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 2430
++ +N W+ + ++ R L+ET +QQ ++ WL E+
Sbjct: 1307 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EA 1364
Query: 2431 ELAKPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 2483
E ++ D+ E ++ + + Q+LQ +IE H+ ++ + +L +
Sbjct: 1365 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG 1424
Query: 2484 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 2543
+ DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 1425 -SDDAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 1481
Query: 2544 RTAAFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELIN 2584
+ + G + +++ AF+R++ + L LE +
Sbjct: 1482 DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLY 1541
Query: 2585 KQYRRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 2643
++ R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 1542 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD- 1600
Query: 2644 ILVWLTEMDLQLTNIE 2659
E+DL+L E
Sbjct: 1601 ------ELDLKLRQAE 1610
Score = 142 bits (358), Expect = 6e-33
Identities = 279/1409 (19%), Positives = 555/1409 (39%), Gaps = 175/1409 (12%)
Query: 1876 LDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLD 1935
L Y+ + + LE I A+E L IQE + + Q+ + + D
Sbjct: 9 LSYKKAVRRQKLLEQSIQSAQET--------EKSLHLIQESLTFIDKQLAAYIADKVDAA 60
Query: 1936 RLNELGYRLP-------LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 1988
++ + ++ ++ +E+K+ + SQ KLQ ++ + F +K
Sbjct: 61 QMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLF-QK 119
Query: 1989 CETWMEFLVQTEQKL--------AVEISGNYQHLLEQQRAH--ELFQAEMFSRQQILHSI 2038
+ + L +++ L A+E Q +++ Q H L+++ + ++ +
Sbjct: 120 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEV-EMV 178
Query: 2039 IIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
I G++++++ Q ++ E + ++T L + + + +R+ ++ ++ ++ R+
Sbjct: 179 IKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNV 238
Query: 2099 LRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL 2156
L +WL ++ S + +P L + + + KE + +Q ++ ++ + L
Sbjct: 239 LTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE---IEKQKVHLKSITEVGEAL 294
Query: 2157 LSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGI---------A 2207
+ E ++ +L+ + W + + R EE L K E ++ + A
Sbjct: 295 KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 354
Query: 2208 DSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYIS 2267
D+L L +KK Q D + L AE ++ V S D L + +
Sbjct: 355 DTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDSTRDQAANLMANRGDHCRKLV 409
Query: 2268 ADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV 2327
IS LN R + + H++ + I L E F N ++ + L +E+++
Sbjct: 410 EPQISELNHR-------FAAISHRIKTGKASIP--LKELEQF---NSDIQKLLEPLEAEI 457
Query: 2328 SQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLA-KASHESKASEIEYKLGKV 2386
Q ++ E+ + + +D + + +L Q G+ L + + E K EI+ K +
Sbjct: 458 QQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNLQQRITDERKREEIKIKQQLL 510
Query: 2387 NDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK-PIVYDSCNSEE 2445
+ L DL + R KK E Q + L L IE +LA P D +E
Sbjct: 511 QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 570
Query: 2446 IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWR 2505
I R+L +++E + + + G++ D A E IQ L +RWR
Sbjct: 571 IDRELQKKKEELNAVRRQAEGLSE------------DGAAMAVEPTQIQ-----LSKRWR 613
Query: 2506 NI-CAMSMERRLKI-------EETWRLWQK------------FLDDYSRFEDWLKSSERT 2545
I + RRL EET + + +L + + L E+
Sbjct: 614 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 673
Query: 2546 AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELINKQYRRLARENRTDSACS 2601
P + E+L K E + + + L Q +++I+ + +
Sbjct: 674 LNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVK 729
Query: 2602 LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 2661
L++ + + + +W+ + K R + + F WLTE + Q
Sbjct: 730 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQI 788
Query: 2662 SECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 2720
E AK K LK Q I + + A GE++I++S DA+I++E+L L
Sbjct: 789 PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW 848
Query: 2721 QEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 2778
QEV ++ K+L L + + DL++ L LE++ ++ + L
Sbjct: 849 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 908
Query: 2779 SNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESA------MSRALPS 2829
L L L Q + + + P V S P+ + L L+ +SRALP
Sbjct: 909 VKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKLENKLKQTNLQWIKVSRALP- 966
Query: 2830 EDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL--------------GKALDDSRFQIQQ 2875
E Q + + ++ L LE Q+ L + + F +Q+
Sbjct: 967 ---EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQE 1023
Query: 2876 TENIIRSKTPTGPEL----------DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 2925
TE +++K P E+ + + + L + SS +V RL +L+ ++ L
Sbjct: 1024 TEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDL 1083
Query: 2926 -PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
PG + ++ TQT ++ + + + A+SK L M +L +D N W L D
Sbjct: 1084 APGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLMLEVPALADFNRAWTELTDWL 1142
Query: 2985 EELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKES 3041
L+Q+ + + + D++ I I K K + ++ R+ + + + + ++E+
Sbjct: 1143 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA 1202
Query: 3042 RD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQCQGFHEMSHGLLLMLENIDRR 3096
R + DR+ ++ +WD V L+ R +L+D+ + E L ++
Sbjct: 1203 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 1262
Query: 3097 KNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAK 3156
K +D+ +Q + Q+ +L + Q V D++ +LL + D
Sbjct: 1263 KEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADD----T 1312
Query: 3157 EKVHVIGNRLKLLLKEVSRHIKELEKLLD 3185
KVH+I + + + + + E E L+
Sbjct: 1313 RKVHMITENINASWRSIHKRVSEREAALE 1341
Score = 134 bits (336), Expect = 2e-30
Identities = 328/1743 (18%), Positives = 678/1743 (38%), Gaps = 241/1743 (13%)
Query: 1539 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAK 1598
+LLE ++S E E ++ ++ +K+L I D+ ++ Q ++ + +
Sbjct: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSH 76
Query: 1599 EKEVEKIEQNG------------LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLK 1646
E +E+++++ + + Q K +DVS L Q AN + + + K
Sbjct: 77 EISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESK 131
Query: 1647 ILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEK 1706
++L E + L + E VQ Q+++ NL L +
Sbjct: 132 MILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSE 170
Query: 1707 QERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQ 1766
+ ++ Q++++ + L + + + +N L ++ E+ Q + L+L +
Sbjct: 171 VKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSR 230
Query: 1767 RYKDYSKQCASTVQQQEDRTNELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDS 1823
+ + K+ + EL K + + + D EVA W + K + K
Sbjct: 231 KMR---KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVH 283
Query: 1824 LFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----E 1879
L + E+GE LK + + D+LSL + ++ +L +L+Y E
Sbjct: 284 LKSITEVGEALKTVLGKK--ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHME 338
Query: 1880 TFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE 1939
TF ++++ + WI++A+ +L S+ Q++ + LK + + + P +D +
Sbjct: 339 TFDQNVDHITKWIIQADTLLD------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRD 392
Query: 1940 LGYRLPLNDKEIKR------MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETW 1992
L N + R + LN ++ IS + T + S L Q + ++K
Sbjct: 393 QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEP 452
Query: 1993 MEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVD 2052
+E +Q L E + +E E+ R L I D ++
Sbjct: 453 LEAEIQQGVNLKEEDFNK-----DMNEDNEGTVKELLQRGDNLQQRITDERK-------- 499
Query: 2053 DRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMS 2112
R+E +K LL + + QRR QW +Y+ A+ L K L ++
Sbjct: 500 -REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----K 554
Query: 2113 GLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELA 2172
L S+P P DE + KE Q+ L + LS D GA A++
Sbjct: 555 KLASLPEPR-------DERKIKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQI 606
Query: 2173 EIQEKWKSASMRLEEQKKKLAF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQ 2222
++ ++W+ + Q ++L F ++ E I+ T +SQ
Sbjct: 607 QLSKRWREIESKFA-QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQ 665
Query: 2223 SLPDHHEELHAEQMRCKELEN------AVGSWTDDLTQLSLLKDTL-----SAYISADDI 2271
+L + + L+A + K+ E+ ++ + D L Q S D + +A SA +
Sbjct: 666 ALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV 725
Query: 2272 SI--LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ 2329
L E + L QWE++ R+ + + +W F K +WLT+ E + +
Sbjct: 726 ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK 785
Query: 2330 NGDILIEEMIEKLK-----KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 2384
I E E K K+ Q+ I Q L GE + + S ++ AS ++ KLG
Sbjct: 786 TQ---IPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 842
Query: 2385 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 2444
+N RWQ + ++ R K+L+E + + ++++ WL ++ + P+ + +
Sbjct: 843 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQ 900
Query: 2445 EIQRKLNEQQELQRDIEKHSTGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDR 2502
+++ KL + + L ++ G+ LN VL+ A + E D ++ + +
Sbjct: 901 QLKEKLEQVKLLVEELPLRQ-GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNL 956
Query: 2503 RWRNICAMSMERRLKIE----ETWRLWQKFLDDYSRFED---WLK----------SSERT 2545
+W + E++ +IE + +L +K D + WL +
Sbjct: 957 QWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQE 1016
Query: 2546 AAFPSSSGVIYTVAKE---------------ELKKFEAFQRQVHECLTQLELINKQYRRL 2590
F I AK+ E + +R++ + ++ + +N+ + L
Sbjct: 1017 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL 1076
Query: 2591 ARENRTDSACSLKQMVHEGNQRWDNLQKRV----TSILR-----RLKHFIGQREEFETAR 2641
R + D A L + Q + + V T+I + L + +F A
Sbjct: 1077 -RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 1135
Query: 2642 DSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIE 2699
+ WL+ +D ++ + D+ I + KA Q++ ++E++I + L
Sbjct: 1136 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 1195
Query: 2700 KSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA 2758
K+ +A II + ++ ++ EV ++ ++L + + + E E A
Sbjct: 1196 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 1255
Query: 2759 LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 2818
+ L ++ + Q + LA+ LR +W + D++ D
Sbjct: 1256 RAKLESWKEGPYTVDAIQKKITETKQLAKDLR-----------------QWQTNVDVAND 1298
Query: 2819 LESAMSRALPSEDEEG-----QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF- 2871
L + R ++D ++ + +S +ALE R L + LD +F
Sbjct: 1299 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1358
Query: 2872 ----QIQQTENIIRSKTPTGPELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEE 2921
+ + T N+++ T L+ S K + L GE + D L+ ++
Sbjct: 1359 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1418
Query: 2922 EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 2981
SL G + + + + +W L+ ++L+ ++ + +W++ + L + WL
Sbjct: 1419 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1478
Query: 2982 DTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE- 3040
++EL + + + D ++ Q + ++ + ++ +I+S F E
Sbjct: 1479 LKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1536
Query: 3041 --------------------SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 3080
+R L+ + ++N W+++ +W+ + + L + Q
Sbjct: 1537 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1596
Query: 3081 EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMS 3140
E + L L L + K P+ +L + LQDH +++ ++ E+ + V+ + D++
Sbjct: 1597 EATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLA 1655
Query: 3141 CQL 3143
QL
Sbjct: 1656 RQL 1658
Score = 111 bits (278), Expect = 1e-23
Identities = 257/1300 (19%), Positives = 504/1300 (38%), Gaps = 153/1300 (11%)
Query: 1218 LDEDQQELSRQLEVVESSIPS-VGLVEE--NEDRLIDRITLYQHLKSSLNEYQPKLYQVL 1274
L++ ++ + LE +E+ I V L EE N+D D + L + Q + +
Sbjct: 439 LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR---IT 495
Query: 1275 DDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 1334
D+ KR I I L+++ N L + K + H+ W +Y+ ++ DL+
Sbjct: 496 DERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQ-------WYQYKRQADDLLKC 548
Query: 1335 LQSAKDRLEFWTQ-----QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKS-------- 1381
L + +L + + + +EL+ ++ LNA ++ + + +
Sbjct: 549 LDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL 608
Query: 1382 -----SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDL-LTNIPA--VQEKLHQLQMDK 1433
+ S Q RL T+R E + ++ L ++ +P+ + E H Q
Sbjct: 609 SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQ--- 665
Query: 1434 LPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDF 1493
A+ EV ++ + + ED K K I + LQ+ G +IDI + T
Sbjct: 666 -----ALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSG-RIDIIHSKKT--- 716
Query: 1494 VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYEN 1553
+ LQ S+ VE + E L ++ W+ + + ++ + +E W +
Sbjct: 717 ---AALQ-SATPVE-----RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY 767
Query: 1554 NVQCLKTWFETQEKRLKQQH--RIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLA 1611
+++ W E+ L++ + A + LK+ L+D I ++ V + G
Sbjct: 768 DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEE 824
Query: 1612 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLM 1671
+IQ + +SI+ L L W + + K L+ + S + ++ +L
Sbjct: 825 IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE 884
Query: 1672 EARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC--HPPV 1729
EA +++ L G + ++ +++ ++ L ++L ++ L++ +L P
Sbjct: 885 EAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE 943
Query: 1730 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALL----QLWQRYKDYSKQCASTVQQQEDR 1785
+ L N LK+ N++W + + E+ +A + QL ++ +D +Q +
Sbjct: 944 QDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 1003
Query: 1786 TNEL-LKAATNK----DIADDEVATWIQ--DCNDLL-KGLGTVKDSLFF------LHELG 1831
N+L + N+ D+ + E+A + D ++L KG K+ L +L
Sbjct: 1004 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 1063
Query: 1832 EQLK-----------QQVDAS------AASAIQSDQLSLSQHLCALEQALCKQQ--TSLQ 1872
+ K +Q D + AS Q+ L ++Q + E A+ K + +SL
Sbjct: 1064 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL-VTQPVVTKETAISKLEMPSSLM 1122
Query: 1873 AGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAP 1932
V F ++ L W+ +++++ Q DL I E + + K M P
Sbjct: 1123 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRP 1181
Query: 1933 DLDRLNELGYRLP--LNDKEIK-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF 1985
L+ L L +++E + R++ + W + R +L L +
Sbjct: 1182 QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQW 1241
Query: 1986 LEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIID--GQ 2043
LE E + L Q KL G Y Q++ E Q RQ + + +
Sbjct: 1242 LEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLAL 1301
Query: 2044 RLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL 2103
+LL DD + ++ ++ W+ + +R +R ++ R Q++ EK WL
Sbjct: 1302 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL 1361
Query: 2104 VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE--KVFLRQQGS-------YILTVEAGKQ 2154
E + + ++ R L D KE K + QG Y E ++
Sbjct: 1362 TEAE----TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQK 1417
Query: 2155 LLLSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL 2213
+L S + +A LQ L + KW + + L W++ + + L L
Sbjct: 1418 ILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL 1477
Query: 2214 RTFKKKLSQSLP--------DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
+ +LS+ P ++H R + + V T + ++ L + L
Sbjct: 1478 QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL 1537
Query: 2266 IS-------------ADDIS-ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSE 2311
A +++ +L ++ E + +WE+L + +++I E L E
Sbjct: 1538 EKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1597
Query: 2312 KNKELCEWLTQME---SKVSQNGDILIEEMIEKLK--KDYQEEIAIAQENKIQLQQMGER 2366
EL L Q E GD+LI+ + + L+ K + EIA +EN + + +
Sbjct: 1598 ATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQ 1657
Query: 2367 LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKE 2406
L + + L +N RW+ L + RV++L E
Sbjct: 1658 LTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVEDRVRQLHE 1696
Score = 99.0 bits (245), Expect = 7e-20
Identities = 328/1758 (18%), Positives = 692/1758 (39%), Gaps = 282/1758 (16%)
Query: 428 AERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALE 487
A+++Q+D H + + + G E +A L + + + L++V S K R +
Sbjct: 66 AQKIQSDLTS-HEISLEEMKKHNQGKE-AAQRVLSQIDVAQKKLQDV-SMKFRLFQKPAN 122
Query: 488 RQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 547
+Q+ Q+S KM E+K+ +S E ++ + Q ++ + L ++E++S
Sbjct: 123 FEQRLQES------KMILDEVKMHLPALETKSVEQEVVQSQ--LNHCVNLYKSLSEVKSE 174
Query: 548 L------AEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLE 601
+ ++V + +P E L +T L + + K + ++Q LE+ L
Sbjct: 175 VEMVIKTGRQIVQKKQTENPKE---LDERVTALKLHYNELGAKVTERKQQLEKCL----- 226
Query: 602 EQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKV 661
+ ++ R E + L WL +T L + P ++++++ + EIE++
Sbjct: 227 -----KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQK 281
Query: 662 VALSELSVHNENL-LLEGKAHT--KDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTA 718
V L ++ E L + GK T +D+ L + E L + Q +M
Sbjct: 282 VHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHM---- 337
Query: 719 QEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQEL-AEQKSLLRSVAS 777
E + +VD + +W+ QA T + + QQ++++ + L AE + V S
Sbjct: 338 -ETFDQNVD-------HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS 389
Query: 778 RGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMK-------WESLHQEF 830
++ AA + G+ L + E A R+K + L Q
Sbjct: 390 TRDQ------AANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFN 443
Query: 831 STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS 890
S QKLL+ + + Q+ V + + D+ ++ V LL + + ++
Sbjct: 444 SDIQKLLEPLEAEIQQGVNLKEED--------FNKDMNEDNEGTVKELLQRGDNLQQRIT 495
Query: 891 SQSGGAKRQSIHLEQKLYD----------------GVSATSTW-------------LDDV 921
+ KR+ I ++Q+L + + W LDD+
Sbjct: 496 DE---RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDI 552
Query: 922 EERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLF------SQAFPENGDNR 975
E++L A LPE + + IKE+ E+ K K ++ E+G
Sbjct: 553 EKKL----ASLPEPRD---------ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 599
Query: 976 DVIEDTLGCLLGRLSLLDSVVNQ-------RCHQMKERLQQILNFQNDLKVLF---TSLA 1025
+E T L R ++S Q + H ++E ++ L++ + T L
Sbjct: 600 -AVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT 658
Query: 1026 DNKYI--ILQKLANVFEQP--VAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ------ 1075
+ ++ L ++ + P A+ E + + E+ LK + + R D +
Sbjct: 659 EITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAA 718
Query: 1076 ------VEQPSMQE-LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLET 1128
VE+ +QE LS+L ++++ + R+ ++++ ++ ++ L
Sbjct: 719 LQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTE 778
Query: 1129 GQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFA---VQKETQ 1185
++ + Q I + E K+K Y + L+ + +T+ R + + +Q+ ++
Sbjct: 779 AEQFLRKTQ--IPENWEHA-----KYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 831
Query: 1186 FHTELMAQA--------SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP 1237
++ + V K+ R LE S D E LE + +I
Sbjct: 832 TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIA 890
Query: 1238 SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS-----DLESQ 1292
S+ L E +L +++ + L L Q L Q+ + G +L+S S LE++
Sbjct: 891 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 950
Query: 1293 LNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESAD-------LIHWLQSAKDRLEFW 1345
L Q W+ + + ++ +E +K + + + D L+ WL +++LE +
Sbjct: 951 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY 1010
Query: 1346 TQQSVTVP---QELEM--------VRDHLNAFLEFSKEVDAQSSLK------SSVLSTGN 1388
Q + P QE E+ V + L+ KE A +K SS N
Sbjct: 1011 NQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 1070
Query: 1389 QL---LRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE-KLHQLQMD-----KLPS--- 1436
+L LR K+ D A + + +Q L+T +E + +L+M ++P+
Sbjct: 1071 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALAD 1130
Query: 1437 -RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 1495
A +E+ W+SL++ VI+ + + + I+E + K K D+ ++ ++
Sbjct: 1131 FNRAWTELTDWLSLLDQVIKSQRVMVGD---LEDINEMIIKQKATMQDLEQRRPQLE--- 1184
Query: 1496 QSVLQISSQDVESKRSD---KTDFAEQLGAMNKSW-QILQGLVTEKIQLLEGLLESWSEY 1551
L ++Q++++K S+ +T +++ + W ++ + L + QL E L +S
Sbjct: 1185 --ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 1242
Query: 1552 ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLA 1611
E + + + + K + ++Q + + + L ++ + V+ L
Sbjct: 1243 EAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALK 1302
Query: 1612 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLM 1671
L+++ D + V + +W ++ V + + L+ + +K ++L
Sbjct: 1303 LLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT 1362
Query: 1672 EARYSLS-------RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE 1724
EA + + + RLL S + V+ + Q+LQ ++E + ++L+
Sbjct: 1363 EAETTANVLQDATRKERLLEDS-KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS 1421
Query: 1725 CH-PPVTETLTNTLKEVNMRWNNL----------LEEIAEQ---LQSSKALLQLWQRYKD 1770
L L +N +W+ L LE ++Q L S L +W + KD
Sbjct: 1422 LEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 1481
Query: 1771 --YSKQCA-----STVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVK-- 1821
S+Q VQ+Q D + A +++ E ++ L TV+
Sbjct: 1482 DELSRQAPIGGDFPAVQKQND-----VHRAFKRELKTKEPV--------IMSTLETVRIF 1528
Query: 1822 ------DSLFFLHELGEQLKQQVDASAASAI---QSDQLSLSQHLCALEQALCKQQTSLQ 1872
+ L L++ +L + A + + Q+++++ L A Q +
Sbjct: 1529 LTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSA--DWQRKID 1586
Query: 1873 AGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAP 1932
+ + ++ + L+ + +AE I P + ++Q+ +E++K + + +
Sbjct: 1587 ETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKE 1646
Query: 1933 DLDRLNELGYRL-----PLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLE 1987
++ +N+L +L L+ + +++LN W L+ +R +L H+ F
Sbjct: 1647 NVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHE---AHRDFGP 1703
Query: 1988 KCETWMEFLVQTEQKLAV 2005
+ ++ VQ + A+
Sbjct: 1704 ASQHFLSTSVQGPWERAI 1721
Score = 92.0 bits (227), Expect = 9e-18
Identities = 279/1594 (17%), Positives = 602/1594 (37%), Gaps = 266/1594 (16%)
Query: 17 LGKPLAKKIGKLTELHQQTIR---QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVL 73
LGK KL+ L+ I +AE L+ L + H+E +++ ++ I KWI +A L
Sbjct: 298 LGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 357
Query: 74 AHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQV 130
+ Q +E + + L E +I ++++ ++ L + +C + + Q+
Sbjct: 358 LDESE--KKKPQQKEDVL--KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 413
Query: 131 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE---QAQATLTSPEVGRL 187
+EL + IK ++ K++++F ++++KL LE Q L + +
Sbjct: 414 SELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKD 471
Query: 188 SLKEQLSHRQHLLSEMESLKPKV------QAVQLCQSALRIPEDVVASLPLCHAALRLQE 241
++ + LL ++L+ ++ + +++ Q L+ + + L + ++
Sbjct: 472 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL-----RSQRRK 526
Query: 242 EASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHL-----QQLIEGAHREIEDKPVATSNIQ 296
+A + H Q + + E+++ L ++ I+ RE++ K + ++
Sbjct: 527 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 586
Query: 297 ELQAQISRHEELAQKIKGYQEQIASL--NSKCKMLTMKAKHATMLLTVTEVEGLAEGTED 354
QA+ + A ++ Q Q++ + K + + + TV E E + TED
Sbjct: 587 R-QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE-ETMMVMTED 644
Query: 355 LDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDA 414
+ E+ PS + + + T +S E +++P C
Sbjct: 645 MPLEISYVPSTYLTEI--------THVSQALLE-----VEQLLNAPDLCAKDFEDLFKQE 691
Query: 415 SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 474
++I S+ R+ IH +A+ + P L L WE + +
Sbjct: 692 ESLKNIKDSLQQSSGRIDI----IHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKM 747
Query: 475 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEI 534
++Q ++E+ +++ ++ + + E L ++ P + EH +
Sbjct: 748 YKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP------ENWEHAKYKWYL 801
Query: 535 LMLQDEINELQ------SSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGK 588
LQD I + Q ++ EE++ +S + D + LQ L L R + + S +
Sbjct: 802 KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDAS---ILQEKLGSLNLRWQEVCKQLSDR 858
Query: 589 RQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLM 648
++ LEE Q+ L ++ + +E WL L P KE ++ +L
Sbjct: 859 KKRLEE----------QKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLE 907
Query: 649 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 708
+ ++ E+ + L +L+ +L+ + +E ++L KL++ +++ RAL
Sbjct: 908 QVKLLVEELPLRQGILKQLNETGGPVLVSAPI-SPEEQDKLENKLKQTNLQWIKVSRALP 966
Query: 709 DKQLNMQGTAQE--KEESDVDLTATQSPGVQEWLAQART---TWTQQRQSSLQQQKELEQ 763
+KQ ++ ++ + E ++ Q + WL+ R + Q Q +E E
Sbjct: 967 EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEI 1026
Query: 764 ELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKW 823
+ ++ + + S+G+ + EKP A ++ K
Sbjct: 1027 AVQAKQPDVEEILSKGQHLY------------KEKP---------------ATQPVKRKL 1059
Query: 824 ESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLN 883
E L E+ +LLQ + ++ + L G+ G PTQ + VT +
Sbjct: 1060 EDLSSEWKAVNRLLQELRAKQPD---------LAPGLTTI-GASPTQTVTLVTQPVVTKE 1109
Query: 884 QAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQ 943
A ++ S S+ LE + T L D L + + +Q
Sbjct: 1110 TAISKLEMPS------SLMLEVPALADFNRAWTELTDWLSLL-----------DQVIKSQ 1152
Query: 944 EILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQM 1003
++ D+++++E + K K + QR Q+
Sbjct: 1153 RVMVGDLEDINEMIIKQKATMQD-----------------------------LEQRRPQL 1183
Query: 1004 KERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAG 1063
+E + N +N TS + + II ++IE IQ D ++E
Sbjct: 1184 EELITAAQNLKNK-----TSNQEARTII------------TDRIERIQNQWDEVQE---- 1222
Query: 1064 IIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLA 1123
LQ + + E+ K Q L K + E+ L
Sbjct: 1223 ---------HLQNRRQQLNEMLK-----------------DSTQWLEAKEEAEQVLGQAR 1256
Query: 1124 DLLETGQEKMAGDQKIIVSSKE--EIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ 1181
LE+ +E G + K+ E +QL +++ ++ L L R + +
Sbjct: 1257 AKLESWKE---GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTR 1313
Query: 1182 KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGL 1241
K + A ++ KR +R LE ET L + +L + L + + + +
Sbjct: 1314 KVHMITENINASWRSIHKRVSEREAALE---ETHRLLQQFPLDLEKFLAWLTEAETTANV 1370
Query: 1242 VEE--NEDRLI-------DRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---- 1288
+++ ++RL+ + + +Q L+ + + + + ++ +++L S+ SD
Sbjct: 1371 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 1430
Query: 1289 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ 1348
L+ +L+ + W K LE W R +L+ WLQ D L +
Sbjct: 1431 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL----SR 1486
Query: 1349 SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVD----------- 1397
+ + V+ + F +E+ + + S L T L + ++
Sbjct: 1487 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 1546
Query: 1398 ----------TATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 1447
T LR + ++++W L + Q K+ + +++L ++ + +
Sbjct: 1547 LPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE-TLERLQELQEATDELD-L 1604
Query: 1448 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVE 1507
L + + K + ++ ++L+K K + +I + V VN Q+++ ++
Sbjct: 1605 KLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQ 1664
Query: 1508 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLL 1541
+ + + +N W++LQ V ++++ L
Sbjct: 1665 LSPYNLSTLED----LNTRWKLLQVAVEDRVRQL 1694
Score = 54.7 bits (130), Expect = 2e-06
Identities = 173/972 (17%), Positives = 375/972 (38%), Gaps = 93/972 (9%)
Query: 2283 RQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKL 2342
R+ L ++ ++RRQ++ E+ + A +EK+ L I+E + +
Sbjct: 4 RKLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHL------------------IQESLTFI 45
Query: 2343 KKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIEYKLGKVNDRWQHLLDLI 2397
K IA +K+ QM + K SHE E++ K + + Q +L I
Sbjct: 46 DKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK-KHNQGKEAAQRVLSQI 100
Query: 2398 AARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLN 2451
KKL++ + + K + + L ++ L + S E +Q +LN
Sbjct: 101 DVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA-LETKSVEQEVVQSQLN 159
Query: 2452 EQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMS 2511
L + + + + V V+ ++ + + L + + A
Sbjct: 160 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELDERVTALKLHYNELGAKV 215
Query: 2512 MERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQR 2571
ER+ ++E+ +L +K + + +WL +++ S+ + + E+ +A Q+
Sbjct: 216 TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK 275
Query: 2572 QVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR 2626
++ + L+ I + L +E + SL N W + R L
Sbjct: 276 EIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------NSNWIAVTSRAEEWLNL 329
Query: 2627 LKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNK 2686
L + E F+ D I W+ + D L E + +K+LKA +I K
Sbjct: 330 LLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI---RPK 386
Query: 2687 IEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD- 2745
++ Q L+ ++E ++ EL + R++ + L D
Sbjct: 387 VDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDI 446
Query: 2746 ---LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS 2801
L E E++ L + ++ D + D+ + + +L Q + ER +
Sbjct: 447 QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 506
Query: 2802 VDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIR 2860
+ + ++ +DL S +AL + Q Y R A L +E ++
Sbjct: 507 QQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKRQADDLLKCLDDIEKKLA 557
Query: 2861 QLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKE 2920
L + D+ + I++ + ++ K + +G + G + + +L + +E
Sbjct: 558 SLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWRE 614
Query: 2921 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 2980
E F L+ + T V + ++ + + E+ + + +++ + L
Sbjct: 615 IESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST-----YLTEITHVSQAL 667
Query: 2981 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 3040
+ E+ L + D + + Q + LK ++ ++ I I+ Q+ +
Sbjct: 668 LEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV 725
Query: 3041 SR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRR 3096
R LQ+ LSQ++ +W++V + ++ +G ++ + + FH ++ + L E R+
Sbjct: 726 ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK 785
Query: 3097 KNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAK 3156
I N + + + K+L + + Q V +L +++ + TD +
Sbjct: 786 TQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASILQ 838
Query: 3157 EKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGR 3214
EK+ + R + + K++S K LE+ ++ S Q+DL+ + +E D S+ G+
Sbjct: 839 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGK 898
Query: 3215 STPNRQKTPRGK 3226
++K + K
Sbjct: 899 EQQLKEKLEQVK 910
Score = 42.0 bits (97), Expect = 0.010
Identities = 66/391 (16%), Positives = 154/391 (39%), Gaps = 49/391 (12%)
Query: 3 LDAAVQKFLEQNGQLGKP-LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
L+A ++ ++Q+ + L +K+G L Q+ +Q +R +L + + L E+ L
Sbjct: 818 LNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLN 877
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEK-----LQY 116
+ W+E+A +A + QL+E+ + L+EE L+ + E +
Sbjct: 878 EFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSA 937
Query: 117 LTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE--- 173
S +K+ ++ + + ++ + + + ++ KD+ + E +L+ L+ L
Sbjct: 938 PISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLL 997
Query: 174 ----------------------QAQATLTSPEVGRLSLKEQLSHRQHLLSE--------- 202
Q T + + + ++E LS QHL E
Sbjct: 998 LWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKR 1057
Query: 203 -MESLKPKVQAVQLCQSALRIPE-DVVASLPLCHAA----LRLQEEASRLQHTAIQQCNI 256
+E L + +AV LR + D+ L A+ + L + + TAI + +
Sbjct: 1058 KLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEM 1117
Query: 257 MQAAVVQ---YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIK 313
+ +++ + + L + + I+ + V +++++ I + + Q ++
Sbjct: 1118 PSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE 1177
Query: 314 GYQEQIASLNSKCKMLTMKAKHATMLLTVTE 344
+ Q+ L + + L K + +T+
Sbjct: 1178 QRRPQLEELITAAQNLKNKTSNQEARTIITD 1208
>gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]
Length = 2344
Score = 161 bits (407), Expect = 1e-38
Identities = 305/1739 (17%), Positives = 653/1739 (37%), Gaps = 231/1739 (13%)
Query: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI-EAIQQAEDGLKEFD 1061
+++ +Q + L ++ SL +I Q A + ++ A Q+ + Q+ + L +
Sbjct: 24 LEQSIQSAQETEKSLHLIQESLT---FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHE 80
Query: 1062 AGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQD 1121
+ E+K+ + Q + ++ Q ++ M + N +E+ LQ+
Sbjct: 81 ISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN--------FEQRLQE 132
Query: 1122 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ 1181
+L+ + + + V +E +Q L+ ++ L E + + +
Sbjct: 133 SKMILDEVKMHLPALETKSVE-QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 191
Query: 1182 KETQFHTELMAQASAVLKRAHKRGV-------ELEYILETWSHLDEDQQELSRQLEVVES 1234
K+T+ EL + +A+ ++ G +LE L+ + ++ L+ L +
Sbjct: 192 KQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDM 251
Query: 1235 SIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD--LESQ 1292
+ VE L + + + + + + L + + G+ L + + +E +
Sbjct: 252 ELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDK 311
Query: 1293 LNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTV 1352
L+ L W++ T++ + L+ L KH + + W+ A L+ +
Sbjct: 312 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD---ESEKKK 368
Query: 1353 PQELEMVRDHLNAFL-EFSKEVDAQSSLKSSVLST-GNQLLRLKKVDTATLRSELSRIDS 1410
PQ+ E V L A L + +VD+ +++++ G+ +L + + L + I
Sbjct: 369 PQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISH 428
Query: 1411 QWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAI 1470
+ +IP + + + KL +E+ ++L E KD N +
Sbjct: 429 RIKTGKASIPLKELEQFNSDIQKL-LEPLEAEIQQGVNLKEEDFNKD----MNEDNEGTV 483
Query: 1471 HEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQIL 1530
E LQ+ N +Q D + ++I Q +++K + D Q
Sbjct: 484 KELLQR------GDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQ----------- 526
Query: 1531 QGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD 1590
+ + LE + W +Y+ L + EK+L D+ ++ ++ Q
Sbjct: 527 -----RRKKALE-ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQK 580
Query: 1591 LEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKIL-- 1648
++ + A ++ E + ++G A+ V T +L + W ++ Q + L
Sbjct: 581 KKEELNAVRRQAEGLSEDGAAM----------AVEPTQIQLSKRWREIESKFAQFRRLNF 630
Query: 1649 --LKSVLDQW----------------SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAV 1690
+ +V ++ S++ ++ L+E L+ L E +
Sbjct: 631 AQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDL 690
Query: 1691 QVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE 1750
Q ++L+N++D L++ + S L+ P L L +++ +W + +
Sbjct: 691 FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKM 750
Query: 1751 IAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDC 1810
++ ++ W+R+ K Q + L+ + + W
Sbjct: 751 YKDRQGRFDRSVEKWRRFHYDIK----IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--L 804
Query: 1811 NDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTS 1870
+L G+G + + L+ GE++ QQ + AS +Q SL+ Q +CKQ +
Sbjct: 805 KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW----QEVCKQLSD 860
Query: 1871 LQAGVLDYET----FAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLK 1926
+ + + + F + L W+ EA+ I P ++E++E++K + +
Sbjct: 861 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNI--ASIPLEPGKEQQLKEKLEQVKLLVEE 918
Query: 1927 FSSMAPDLDRLNELG----YRLPLNDKEIKRMQN----LNRHWSLISSQTTERFSKLQSF 1978
L +LNE G P++ +E +++N N W +S E+ ++++
Sbjct: 919 LPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQ 978
Query: 1979 LLQHQTFLEKCETWME-------FLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSR 2031
+ +K E E +L +L + N + + Q QA +
Sbjct: 979 IKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA----K 1034
Query: 2032 QQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQR 2091
Q + I+ GQ L ++ KL LS++W+ V R Q+
Sbjct: 1035 QPDVEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQE-------------- 1078
Query: 2092 YREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEA 2151
R L L + P + V P+ T + L S +L V A
Sbjct: 1079 LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK--------LEMPSSLMLEVPA 1130
Query: 2152 GKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE 2211
LA+ W L DW L+
Sbjct: 1131 -------------------LADFNRAWTE---------------LTDW-------LSLLD 1149
Query: 2212 KLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDI 2271
++ ++ + L D +E + ++ ++LE + +T LK+ S + +
Sbjct: 1150 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS---NQEAR 1206
Query: 2272 SILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVS--Q 2329
+I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E + L Q +K+ +
Sbjct: 1207 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 1266
Query: 2330 NGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVN 2387
G ++ + +K+ K +++ Q N + +L + ++ +N
Sbjct: 1267 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 1326
Query: 2388 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEE-- 2445
W+ + ++ R L+ET +QQ ++ WL E+E ++ D+ E
Sbjct: 1327 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETTANVLQDATRKERLL 1384
Query: 2446 -----IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNL 2500
++ + + Q+LQ +IE H+ ++ + +L + + DA +Q+ N+
Sbjct: 1385 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SDDAVL--LQRRLDNM 1441
Query: 2501 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAK 2560
+ +W + S+ R +E + W++ WL+ + + + G + +
Sbjct: 1442 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 1501
Query: 2561 EELKKFEAFQRQV-------------------HECLTQLELINKQYRRLARENRTDSACS 2601
++ AF+R++ + L LE + ++ R L E R +
Sbjct: 1502 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTR 1561
Query: 2602 -LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 2659
L++ E N W+ L R++ + + +E + A D E+DL+L E
Sbjct: 1562 LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD-------ELDLKLRQAE 1613
Score = 141 bits (355), Expect = 1e-32
Identities = 275/1389 (19%), Positives = 550/1389 (39%), Gaps = 168/1389 (12%)
Query: 1896 EEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-------LND 1948
E+ +Q + S L IQE + + Q+ + + D ++ + ++ ++
Sbjct: 25 EQSIQSAQETEKS-LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISL 83
Query: 1949 KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL----- 2003
+E+K+ + SQ KLQ ++ + F +K + + L +++ L
Sbjct: 84 EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLF-QKPANFEQRLQESKMILDEVKM 142
Query: 2004 ---AVEISGNYQHLLEQQRAH--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFN 2058
A+E Q +++ Q H L+++ + ++ +I G++++++ Q ++ E +
Sbjct: 143 HLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELD 201
Query: 2059 LKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGS 2116
++T L + + + +R+ ++ ++ ++ R+ L +WL ++ S +
Sbjct: 202 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 261
Query: 2117 VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQE 2176
+P L + + + KE + +Q ++ ++ + L + E ++ +L+ +
Sbjct: 262 MPSNLD-SEVAWGKATQKE---IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNS 317
Query: 2177 KWKSASMRLEEQKKKLAFLLKDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDH 2227
W + + R EE L K E ++ + AD+L L +KK Q D
Sbjct: 318 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDV 375
Query: 2228 HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEE 2287
+ L AE ++ V S D L + + IS LN R +
Sbjct: 376 LKRLKAE---LNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR-------FAA 425
Query: 2288 LCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQ 2347
+ H++ + I L E F N ++ + L +E+++ Q ++ E+ + + +D +
Sbjct: 426 ISHRIKTGKASIP--LKELEQF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 480
Query: 2348 EEIAIAQENKIQLQQMGERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKE 2406
+ +L Q G+ L + + E K EI+ K + + L DL + R KK E
Sbjct: 481 GTVK-------ELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALE 533
Query: 2407 TLVAVQQLDKNMSSLRTWLAHIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHST 2465
Q + L L IE +LA P D +EI R+L +++E + + +
Sbjct: 534 ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAE 593
Query: 2466 GVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI------ 2518
G++ D A E IQ L +RWR I + RRL
Sbjct: 594 GLSE------------DGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTV 636
Query: 2519 -EETWRLWQK------------FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKK 2565
EET + + +L + + L E+ P + E+L K
Sbjct: 637 REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFK 692
Query: 2566 FEAFQRQVHECLTQ----LELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVT 2621
E + + + L Q +++I+ + + L++ + + + +W+ + K
Sbjct: 693 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 752
Query: 2622 SILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEI 2680
R + + F WLTE + Q E AK K LK Q I
Sbjct: 753 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGI 811
Query: 2681 SLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP-- 2738
+ + A GE++I++S DA+I++E+L L QEV ++ K+L
Sbjct: 812 GQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI 871
Query: 2739 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSG 2795
L + + DL++ L LE++ ++ + L L L L Q + + +
Sbjct: 872 LSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNE 931
Query: 2796 RDTPASVDSIPLEWDHDYDLSRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLS 2849
P V S P+ + L L+ +SRALP E Q + + ++ L
Sbjct: 932 TGGPVLV-SAPISPEEQDKLENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLE 986
Query: 2850 GDHSALESQIRQL--------------GKALDDSRFQIQQTENIIRSKTPTGPEL----- 2890
LE Q+ L + + F +Q+TE +++K P E+
Sbjct: 987 KKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 1046
Query: 2891 -----DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDR 2944
+ + + L + SS +V RL +L+ ++ L PG + ++ TQT ++ +
Sbjct: 1047 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 1106
Query: 2945 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTI 3002
+ + A+SK L M +L +D N W L D L+Q+ + + + D++ I
Sbjct: 1107 PVVTKETAISK-LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDI 1165
Query: 3003 ELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCS 3060
I K K + ++ R+ + + + + ++E+R + DR+ ++ +WD V
Sbjct: 1166 NEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQE 1225
Query: 3061 LLEEWR----GLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHH 3116
L+ R +L+D+ + E L ++ K +D+ +Q
Sbjct: 1226 HLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKI 1279
Query: 3117 KQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRH 3176
+ Q+ +L + Q V D++ +LL + D KVH+I + + + +
Sbjct: 1280 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKR 1335
Query: 3177 IKELEKLLD 3185
+ E E L+
Sbjct: 1336 VSEREAALE 1344
Score = 134 bits (336), Expect = 2e-30
Identities = 328/1743 (18%), Positives = 678/1743 (38%), Gaps = 241/1743 (13%)
Query: 1539 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAK 1598
+LLE ++S E E ++ ++ +K+L I D+ ++ Q ++ + +
Sbjct: 22 KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSH 79
Query: 1599 EKEVEKIEQNG------------LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLK 1646
E +E+++++ + + Q K +DVS L Q AN + + + K
Sbjct: 80 EISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESK 134
Query: 1647 ILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEK 1706
++L E + L + E VQ Q+++ NL L +
Sbjct: 135 MILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSE 173
Query: 1707 QERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQ 1766
+ ++ Q++++ + L + + + +N L ++ E+ Q + L+L +
Sbjct: 174 VKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSR 233
Query: 1767 RYKDYSKQCASTVQQQEDRTNELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDS 1823
+ + K+ + EL K + + + D EVA W + K + K
Sbjct: 234 KMR---KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVH 286
Query: 1824 LFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----E 1879
L + E+GE LK + + D+LSL + ++ +L +L+Y E
Sbjct: 287 LKSITEVGEALKTVLGKK--ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHME 341
Query: 1880 TFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE 1939
TF ++++ + WI++A+ +L S+ Q++ + LK + + + P +D +
Sbjct: 342 TFDQNVDHITKWIIQADTLLD------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRD 395
Query: 1940 LGYRLPLNDKEIKR------MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETW 1992
L N + R + LN ++ IS + T + S L Q + ++K
Sbjct: 396 QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEP 455
Query: 1993 MEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVD 2052
+E +Q L E + +E E+ R L I D ++
Sbjct: 456 LEAEIQQGVNLKEEDFNK-----DMNEDNEGTVKELLQRGDNLQQRITDERK-------- 502
Query: 2053 DRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMS 2112
R+E +K LL + + QRR QW +Y+ A+ L K L ++
Sbjct: 503 -REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----K 557
Query: 2113 GLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELA 2172
L S+P P DE + KE Q+ L + LS D GA A++
Sbjct: 558 KLASLPEPR-------DERKIKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQI 609
Query: 2173 EIQEKWKSASMRLEEQKKKLAF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQ 2222
++ ++W+ + Q ++L F ++ E I+ T +SQ
Sbjct: 610 QLSKRWREIESKFA-QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQ 668
Query: 2223 SLPDHHEELHAEQMRCKELEN------AVGSWTDDLTQLSLLKDTL-----SAYISADDI 2271
+L + + L+A + K+ E+ ++ + D L Q S D + +A SA +
Sbjct: 669 ALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV 728
Query: 2272 SI--LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ 2329
L E + L QWE++ R+ + + +W F K +WLT+ E + +
Sbjct: 729 ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK 788
Query: 2330 NGDILIEEMIEKLK-----KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 2384
I E E K K+ Q+ I Q L GE + + S ++ AS ++ KLG
Sbjct: 789 TQ---IPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 845
Query: 2385 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 2444
+N RWQ + ++ R K+L+E + + ++++ WL ++ + P+ + +
Sbjct: 846 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQ 903
Query: 2445 EIQRKLNEQQELQRDIEKHSTGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDR 2502
+++ KL + + L ++ G+ LN VL+ A + E D ++ + +
Sbjct: 904 QLKEKLEQVKLLVEELPLRQ-GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNL 959
Query: 2503 RWRNICAMSMERRLKIE----ETWRLWQKFLDDYSRFED---WLK----------SSERT 2545
+W + E++ +IE + +L +K D + WL +
Sbjct: 960 QWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQE 1019
Query: 2546 AAFPSSSGVIYTVAKE---------------ELKKFEAFQRQVHECLTQLELINKQYRRL 2590
F I AK+ E + +R++ + ++ + +N+ + L
Sbjct: 1020 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL 1079
Query: 2591 ARENRTDSACSLKQMVHEGNQRWDNLQKRV----TSILR-----RLKHFIGQREEFETAR 2641
R + D A L + Q + + V T+I + L + +F A
Sbjct: 1080 -RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 1138
Query: 2642 DSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIE 2699
+ WL+ +D ++ + D+ I + KA Q++ ++E++I + L
Sbjct: 1139 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 1198
Query: 2700 KSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA 2758
K+ +A II + ++ ++ EV ++ ++L + + + E E A
Sbjct: 1199 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 1258
Query: 2759 LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 2818
+ L ++ + Q + LA+ LR +W + D++ D
Sbjct: 1259 RAKLESWKEGPYTVDAIQKKITETKQLAKDLR-----------------QWQTNVDVAND 1301
Query: 2819 LESAMSRALPSEDEEG-----QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF- 2871
L + R ++D ++ + +S +ALE R L + LD +F
Sbjct: 1302 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1361
Query: 2872 ----QIQQTENIIRSKTPTGPELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEE 2921
+ + T N+++ T L+ S K + L GE + D L+ ++
Sbjct: 1362 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1421
Query: 2922 EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 2981
SL G + + + + +W L+ ++L+ ++ + +W++ + L + WL
Sbjct: 1422 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1481
Query: 2982 DTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE- 3040
++EL + + + D ++ Q + ++ + ++ +I+S F E
Sbjct: 1482 LKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1539
Query: 3041 --------------------SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 3080
+R L+ + ++N W+++ +W+ + + L + Q
Sbjct: 1540 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1599
Query: 3081 EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMS 3140
E + L L L + K P+ +L + LQDH +++ ++ E+ + V+ + D++
Sbjct: 1600 EATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLA 1658
Query: 3141 CQL 3143
QL
Sbjct: 1659 RQL 1661
Score = 111 bits (278), Expect = 1e-23
Identities = 257/1300 (19%), Positives = 504/1300 (38%), Gaps = 153/1300 (11%)
Query: 1218 LDEDQQELSRQLEVVESSIPS-VGLVEE--NEDRLIDRITLYQHLKSSLNEYQPKLYQVL 1274
L++ ++ + LE +E+ I V L EE N+D D + L + Q + +
Sbjct: 442 LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR---IT 498
Query: 1275 DDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 1334
D+ KR I I L+++ N L + K + H+ W +Y+ ++ DL+
Sbjct: 499 DERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQ-------WYQYKRQADDLLKC 551
Query: 1335 LQSAKDRLEFWTQ-----QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKS-------- 1381
L + +L + + + +EL+ ++ LNA ++ + + +
Sbjct: 552 LDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL 611
Query: 1382 -----SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDL-LTNIPA--VQEKLHQLQMDK 1433
+ S Q RL T+R E + ++ L ++ +P+ + E H Q
Sbjct: 612 SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQ--- 668
Query: 1434 LPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDF 1493
A+ EV ++ + + ED K K I + LQ+ G +IDI + T
Sbjct: 669 -----ALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSG-RIDIIHSKKT--- 719
Query: 1494 VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYEN 1553
+ LQ S+ VE + E L ++ W+ + + ++ + +E W +
Sbjct: 720 ---AALQ-SATPVE-----RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY 770
Query: 1554 NVQCLKTWFETQEKRLKQQH--RIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLA 1611
+++ W E+ L++ + A + LK+ L+D I ++ V + G
Sbjct: 771 DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEE 827
Query: 1612 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLM 1671
+IQ + +SI+ L L W + + K L+ + S + ++ +L
Sbjct: 828 IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE 887
Query: 1672 EARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC--HPPV 1729
EA +++ L G + ++ +++ ++ L ++L ++ L++ +L P
Sbjct: 888 EAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE 946
Query: 1730 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALL----QLWQRYKDYSKQCASTVQQQEDR 1785
+ L N LK+ N++W + + E+ +A + QL ++ +D +Q +
Sbjct: 947 QDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 1006
Query: 1786 TNEL-LKAATNK----DIADDEVATWIQ--DCNDLL-KGLGTVKDSLFF------LHELG 1831
N+L + N+ D+ + E+A + D ++L KG K+ L +L
Sbjct: 1007 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 1066
Query: 1832 EQLK-----------QQVDAS------AASAIQSDQLSLSQHLCALEQALCKQQ--TSLQ 1872
+ K +Q D + AS Q+ L ++Q + E A+ K + +SL
Sbjct: 1067 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL-VTQPVVTKETAISKLEMPSSLM 1125
Query: 1873 AGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAP 1932
V F ++ L W+ +++++ Q DL I E + + K M P
Sbjct: 1126 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRP 1184
Query: 1933 DLDRLNELGYRLP--LNDKEIK-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF 1985
L+ L L +++E + R++ + W + R +L L +
Sbjct: 1185 QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQW 1244
Query: 1986 LEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIID--GQ 2043
LE E + L Q KL G Y Q++ E Q RQ + + +
Sbjct: 1245 LEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLAL 1304
Query: 2044 RLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL 2103
+LL DD + ++ ++ W+ + +R +R ++ R Q++ EK WL
Sbjct: 1305 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL 1364
Query: 2104 VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE--KVFLRQQGS-------YILTVEAGKQ 2154
E + + ++ R L D KE K + QG Y E ++
Sbjct: 1365 TEAE----TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQK 1420
Query: 2155 LLLSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL 2213
+L S + +A LQ L + KW + + L W++ + + L L
Sbjct: 1421 ILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL 1480
Query: 2214 RTFKKKLSQSLP--------DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 2265
+ +LS+ P ++H R + + V T + ++ L + L
Sbjct: 1481 QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL 1540
Query: 2266 IS-------------ADDIS-ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSE 2311
A +++ +L ++ E + +WE+L + +++I E L E
Sbjct: 1541 EKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1600
Query: 2312 KNKELCEWLTQME---SKVSQNGDILIEEMIEKLK--KDYQEEIAIAQENKIQLQQMGER 2366
EL L Q E GD+LI+ + + L+ K + EIA +EN + + +
Sbjct: 1601 ATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQ 1660
Query: 2367 LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKE 2406
L + + L +N RW+ L + RV++L E
Sbjct: 1661 LTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVEDRVRQLHE 1699
Score = 92.0 bits (227), Expect = 9e-18
Identities = 279/1594 (17%), Positives = 602/1594 (37%), Gaps = 266/1594 (16%)
Query: 17 LGKPLAKKIGKLTELHQQTIR---QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVL 73
LGK KL+ L+ I +AE L+ L + H+E +++ ++ I KWI +A L
Sbjct: 301 LGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 360
Query: 74 AHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQV 130
+ Q +E + + L E +I ++++ ++ L + +C + + Q+
Sbjct: 361 LDESE--KKKPQQKEDVL--KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 416
Query: 131 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE---QAQATLTSPEVGRL 187
+EL + IK ++ K++++F ++++KL LE Q L + +
Sbjct: 417 SELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKD 474
Query: 188 SLKEQLSHRQHLLSEMESLKPKV------QAVQLCQSALRIPEDVVASLPLCHAALRLQE 241
++ + LL ++L+ ++ + +++ Q L+ + + L + ++
Sbjct: 475 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL-----RSQRRK 529
Query: 242 EASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHL-----QQLIEGAHREIEDKPVATSNIQ 296
+A + H Q + + E+++ L ++ I+ RE++ K + ++
Sbjct: 530 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 589
Query: 297 ELQAQISRHEELAQKIKGYQEQIASL--NSKCKMLTMKAKHATMLLTVTEVEGLAEGTED 354
QA+ + A ++ Q Q++ + K + + + TV E E + TED
Sbjct: 590 R-QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE-ETMMVMTED 647
Query: 355 LDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDA 414
+ E+ PS + + + T +S E +++P C
Sbjct: 648 MPLEISYVPSTYLTEI--------THVSQALLE-----VEQLLNAPDLCAKDFEDLFKQE 694
Query: 415 SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 474
++I S+ R+ IH +A+ + P L L WE + +
Sbjct: 695 ESLKNIKDSLQQSSGRIDI----IHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKM 750
Query: 475 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEI 534
++Q ++E+ +++ ++ + + E L ++ P + EH +
Sbjct: 751 YKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP------ENWEHAKYKWYL 804
Query: 535 LMLQDEINELQ------SSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGK 588
LQD I + Q ++ EE++ +S + D + LQ L L R + + S +
Sbjct: 805 KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDAS---ILQEKLGSLNLRWQEVCKQLSDR 861
Query: 589 RQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLM 648
++ LEE Q+ L ++ + +E WL L P KE ++ +L
Sbjct: 862 KKRLEE----------QKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLE 910
Query: 649 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 708
+ ++ E+ + L +L+ +L+ + +E ++L KL++ +++ RAL
Sbjct: 911 QVKLLVEELPLRQGILKQLNETGGPVLVSAPI-SPEEQDKLENKLKQTNLQWIKVSRALP 969
Query: 709 DKQLNMQGTAQE--KEESDVDLTATQSPGVQEWLAQART---TWTQQRQSSLQQQKELEQ 763
+KQ ++ ++ + E ++ Q + WL+ R + Q Q +E E
Sbjct: 970 EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEI 1029
Query: 764 ELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKW 823
+ ++ + + S+G+ + EKP A ++ K
Sbjct: 1030 AVQAKQPDVEEILSKGQHLY------------KEKP---------------ATQPVKRKL 1062
Query: 824 ESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLN 883
E L E+ +LLQ + ++ + L G+ G PTQ + VT +
Sbjct: 1063 EDLSSEWKAVNRLLQELRAKQPD---------LAPGLTTI-GASPTQTVTLVTQPVVTKE 1112
Query: 884 QAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQ 943
A ++ S S+ LE + T L D L + + +Q
Sbjct: 1113 TAISKLEMPS------SLMLEVPALADFNRAWTELTDWLSLL-----------DQVIKSQ 1155
Query: 944 EILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQM 1003
++ D+++++E + K K + QR Q+
Sbjct: 1156 RVMVGDLEDINEMIIKQKATMQD-----------------------------LEQRRPQL 1186
Query: 1004 KERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAG 1063
+E + N +N TS + + II ++IE IQ D ++E
Sbjct: 1187 EELITAAQNLKNK-----TSNQEARTII------------TDRIERIQNQWDEVQE---- 1225
Query: 1064 IIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLA 1123
LQ + + E+ K Q L K + E+ L
Sbjct: 1226 ---------HLQNRRQQLNEMLK-----------------DSTQWLEAKEEAEQVLGQAR 1259
Query: 1124 DLLETGQEKMAGDQKIIVSSKE--EIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ 1181
LE+ +E G + K+ E +QL +++ ++ L L R + +
Sbjct: 1260 AKLESWKE---GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTR 1316
Query: 1182 KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGL 1241
K + A ++ KR +R LE ET L + +L + L + + + +
Sbjct: 1317 KVHMITENINASWRSIHKRVSEREAALE---ETHRLLQQFPLDLEKFLAWLTEAETTANV 1373
Query: 1242 VEE--NEDRLI-------DRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---- 1288
+++ ++RL+ + + +Q L+ + + + + ++ +++L S+ SD
Sbjct: 1374 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 1433
Query: 1289 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ 1348
L+ +L+ + W K LE W R +L+ WLQ D L +
Sbjct: 1434 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL----SR 1489
Query: 1349 SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVD----------- 1397
+ + V+ + F +E+ + + S L T L + ++
Sbjct: 1490 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 1549
Query: 1398 ----------TATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 1447
T LR + ++++W L + Q K+ + +++L ++ + +
Sbjct: 1550 LPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE-TLERLQELQEATDELD-L 1607
Query: 1448 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVE 1507
L + + K + ++ ++L+K K + +I + V VN Q+++ ++
Sbjct: 1608 KLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQ 1667
Query: 1508 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLL 1541
+ + + +N W++LQ V ++++ L
Sbjct: 1668 LSPYNLSTLED----LNTRWKLLQVAVEDRVRQL 1697
Score = 88.2 bits (217), Expect = 1e-16
Identities = 301/1697 (17%), Positives = 650/1697 (38%), Gaps = 288/1697 (16%)
Query: 428 AERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALE 487
A+++Q+D H + + + G E +A L + + + L++V S K R +
Sbjct: 69 AQKIQSDLTS-HEISLEEMKKHNQGKE-AAQRVLSQIDVAQKKLQDV-SMKFRLFQKPAN 125
Query: 488 RQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 547
+Q+ Q+S KM E+K+ +S E ++ + Q ++ + L ++E++S
Sbjct: 126 FEQRLQES------KMILDEVKMHLPALETKSVEQEVVQSQ--LNHCVNLYKSLSEVKSE 177
Query: 548 L------AEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLE 601
+ ++V + +P E L +T L + + K + ++Q LE+ L
Sbjct: 178 VEMVIKTGRQIVQKKQTENPKE---LDERVTALKLHYNELGAKVTERKQQLEKCL----- 229
Query: 602 EQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKV 661
+ ++ R E + L WL +T L + P ++++++ + EIE++
Sbjct: 230 -----KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQK 284
Query: 662 VALSELSVHNENL-LLEGKAHT--KDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTA 718
V L ++ E L + GK T +D+ L + E L + Q +M+
Sbjct: 285 VHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 344
Query: 719 QEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQEL-AEQKSLLRSVAS 777
Q + + +W+ QA T + + QQ++++ + L AE + V S
Sbjct: 345 QNVDH------------ITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS 392
Query: 778 RGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKW-------ESLHQEF 830
++ AA + G+ L + E A R+K + L Q
Sbjct: 393 TRDQ------AANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFN 446
Query: 831 STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS 890
S QKLL+ + + Q+ V + + D+ ++ V LL + + ++
Sbjct: 447 SDIQKLLEPLEAEIQQGVNLKEED--------FNKDMNEDNEGTVKELLQRGDNLQQRIT 498
Query: 891 SQSGGAKRQSIHLEQKLYD----------------GVSATSTW-------------LDDV 921
+ KR+ I ++Q+L + + W LDD+
Sbjct: 499 DER---KREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDI 555
Query: 922 EERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFS------QAFPENGDNR 975
E++L A LPE + + IKE+ E+ K K + + E+G
Sbjct: 556 EKKL----ASLPEPRDE---------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 602
Query: 976 DVIEDTLGCLLGRLSLLDSVVNQ-------RCHQMKERLQQILNFQNDLKVLF---TSLA 1025
+E T L R ++S Q + H ++E ++ L++ + T L
Sbjct: 603 -AVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT 661
Query: 1026 DNKYI--ILQKLANVFEQP--VAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ------ 1075
+ ++ L ++ + P A+ E + + E+ LK + + R D +
Sbjct: 662 EITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAA 721
Query: 1076 ------VEQPSMQE-LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLET 1128
VE+ +QE LS+L ++++ + R+ ++++ ++ ++ L
Sbjct: 722 LQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTE 781
Query: 1129 GQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFA---VQKETQ 1185
++ + Q I + E K+K Y + L+ + +T+ R + + +Q+ ++
Sbjct: 782 AEQFLRKTQ--IPENWEHA-----KYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 834
Query: 1186 FHTELMAQA--------SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP 1237
++ + V K+ R LE S D E LE ++ I
Sbjct: 835 TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN-IA 893
Query: 1238 SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD-----LESQ 1292
S+ L E +L +++ + L L Q L Q+ + G +L+S S LE++
Sbjct: 894 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 953
Query: 1293 LNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL-------IHWLQSAKDRLEFW 1345
L Q W+ + + ++ +E +K + + + DL + WL +++LE +
Sbjct: 954 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY 1013
Query: 1346 TQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSEL 1405
Q + P +++ E V A+ +LS G L + K
Sbjct: 1014 NQPNQEGPFDVQ----------ETEIAVQAKQPDVEEILSKGQHLYKEK----------- 1052
Query: 1406 SRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSI 1465
PA Q P + + ++ S
Sbjct: 1053 --------------PATQ-----------PVKRKLEDLSS-------------------- 1067
Query: 1466 GYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNK 1525
+KA++ LQ+ + + D+ T+ + + +Q V +K + A++K
Sbjct: 1068 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET----------AISK 1117
Query: 1526 SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNA 1584
++ L+ E + L +W+E L W ++ +K Q +GD +
Sbjct: 1118 L-EMPSSLMLE-VPALADFNRAWTE-------LTDWLSLLDQVIKSQRVMVGDLEDINEM 1168
Query: 1585 L-KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVG 1643
+ K ++DL + + + E I + ++ +I+ + + W + +
Sbjct: 1169 IIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQ 1228
Query: 1644 QLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDD 1703
+ L +L + A ++ L +AR L ++ +++A+Q ++ + L D
Sbjct: 1229 NRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKD 1288
Query: 1704 LEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQ 1763
L + + ++ + +LL++ T + + +N W ++ + ++E+ + + +
Sbjct: 1289 LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHR 1348
Query: 1764 LWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE--VATWIQDCNDLLKGLGTVK 1821
L Q++ ++ + + + E N L A + + +D V ++ DL +
Sbjct: 1349 LLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 1408
Query: 1822 DSLFFLHELGEQLKQQVDASAASAIQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYET 1880
D L E +++ + ++ S + + +L +++ L + ++ L+A ++
Sbjct: 1409 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 1468
Query: 1881 FAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERME-------ELKG---------QM 1924
SL+ L W+ ++ L Q P D +Q++ + ELK +
Sbjct: 1469 LHLSLQELLVWLQLKDDELSRQAPI-GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 1527
Query: 1925 LKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT 1984
++ L+ L +L Y+ P +R QN+ R L+ Q E ++ + L
Sbjct: 1528 VRIFLTEQPLEGLEKL-YQEPRELPPEERAQNVTR---LLRKQAEEVNTEWEKLNLHSAD 1583
Query: 1985 FLEKCETWMEFLVQTEQ 2001
+ K + +E L + ++
Sbjct: 1584 WQRKIDETLERLQELQE 1600
Score = 53.1 bits (126), Expect = 4e-06
Identities = 164/921 (17%), Positives = 355/921 (38%), Gaps = 75/921 (8%)
Query: 2334 LIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIEYKLGKVND 2388
LI+E + + K IA +K+ QM + K SHE E++ K + +
Sbjct: 40 LIQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK-KHNQGKE 94
Query: 2389 RWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAKPIVYDSCN 2442
Q +L I KKL++ + + K + + L ++ L + S
Sbjct: 95 AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA-LETKSVE 153
Query: 2443 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 2502
E +Q +LN L + + + + V V+ ++ + + L
Sbjct: 154 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELDERVTALKL 209
Query: 2503 RWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEE 2562
+ + A ER+ ++E+ +L +K + + +WL +++ S+ + + E
Sbjct: 210 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
Query: 2563 LKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEGNQRWDNLQ 2617
+ +A Q+++ + L+ I + L +E + SL N W +
Sbjct: 270 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------NSNWIAVT 323
Query: 2618 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 2677
R L L + E F+ D I W+ + D L E + +K+LKA
Sbjct: 324 SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAEL 383
Query: 2678 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRL 2737
+I K++ Q L+ ++E ++ EL + R++ +
Sbjct: 384 NDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLK 440
Query: 2738 PLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLSLAQPLRSE 2792
L D L E E++ L + ++ D + D+ + + +L Q + E
Sbjct: 441 ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDE 500
Query: 2793 RSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLRGAVGLSGD 2851
R + + + ++ +DL S +AL + Q Y R A L
Sbjct: 501 RKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKRQADDLLKC 551
Query: 2852 HSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV 2911
+E ++ L + D+ + I++ + ++ K + +G + G + +
Sbjct: 552 LDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQ 608
Query: 2912 KRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNS 2971
+L + +E E F L+ + T V + ++ + + E+ + + +
Sbjct: 609 IQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST-----YLT 661
Query: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
++ + L + E+ L + D + + Q + LK ++ ++ I I+
Sbjct: 662 EITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 719
Query: 3032 EFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLL 3087
Q+ + R LQ+ LSQ++ +W++V + ++ +G ++ + + FH ++ + L
Sbjct: 720 AALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWL 779
Query: 3088 LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 3147
E R+ I N + + + K+L + + Q V +L +++ +
Sbjct: 780 TEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQS 832
Query: 3148 EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTS 3205
TD +EK+ + R + + K++S K LE+ ++ S Q+DL+ + +E D
Sbjct: 833 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI 892
Query: 3206 GSVSPTSGRSTPNRQKTPRGK 3226
S+ G+ ++K + K
Sbjct: 893 ASIPLEPGKEQQLKEKLEQVK 913
Score = 42.0 bits (97), Expect = 0.010
Identities = 66/391 (16%), Positives = 154/391 (39%), Gaps = 49/391 (12%)
Query: 3 LDAAVQKFLEQNGQLGKP-LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
L+A ++ ++Q+ + L +K+G L Q+ +Q +R +L + + L E+ L
Sbjct: 821 LNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLN 880
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEK-----LQY 116
+ W+E+A +A + QL+E+ + L+EE L+ + E +
Sbjct: 881 EFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSA 940
Query: 117 LTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE--- 173
S +K+ ++ + + ++ + + + ++ KD+ + E +L+ L+ L
Sbjct: 941 PISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLL 1000
Query: 174 ----------------------QAQATLTSPEVGRLSLKEQLSHRQHLLSE--------- 202
Q T + + + ++E LS QHL E
Sbjct: 1001 LWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKR 1060
Query: 203 -MESLKPKVQAVQLCQSALRIPE-DVVASLPLCHAA----LRLQEEASRLQHTAIQQCNI 256
+E L + +AV LR + D+ L A+ + L + + TAI + +
Sbjct: 1061 KLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEM 1120
Query: 257 MQAAVVQ---YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIK 313
+ +++ + + L + + I+ + V +++++ I + + Q ++
Sbjct: 1121 PSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE 1180
Query: 314 GYQEQIASLNSKCKMLTMKAKHATMLLTVTE 344
+ Q+ L + + L K + +T+
Sbjct: 1181 QRRPQLEELITAAQNLKNKTSNQEARTIITD 1211
Score = 35.4 bits (80), Expect = 0.95
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 463 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 522
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 1569 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 1628
Query: 523 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 578
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 1629 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 1683
Query: 579 STIRMKASGKRQLLEEKLND 598
+++ + + L E D
Sbjct: 1684 KLLQVAVEDRVRQLHEAHRD 1703
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 147 bits (372), Expect = 1e-34
Identities = 567/3049 (18%), Positives = 1188/3049 (38%), Gaps = 550/3049 (18%)
Query: 386 EESGEEGTNSEISSP--PACRSPSPVA---NTDASVNQDIAYYQALSAER---LQTDAAK 437
E SG++ T+ + +P P S + T V + +AY + L E ++ +
Sbjct: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQ 74
Query: 438 IHPSTSASQEFYEPG------LEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQK 491
+ A QE + L+ A AKL L + E +K T ++ E+ K
Sbjct: 75 LQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK 134
Query: 492 YQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQAL--------MDEILMLQDEINE 543
+ S ++E I+ KL E E + ++Q+ + QA M+E +M++ ++ E
Sbjct: 135 HDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQE 194
Query: 544 LQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQ 603
EE +S L ++S + + + ++ + E+ + + +
Sbjct: 195 -----KEEFIS------------------TLQAQLSQTQAEQAAQQVVREKDARFETQVR 231
Query: 604 RQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDC-QNMLVEIEQKVV 662
E L + +AD +++ + L L +E + AQ++D Q L EQ+
Sbjct: 232 LHEDELLQLVTQAD-VETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQ 290
Query: 663 ALSEL--SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720
LS+ + E+ L T+ E ++ L +++ + E + + H+ Q M ++
Sbjct: 291 ILSQQLQQMEAEHNTLRNTVETEREESKIL--LEKMELEVAERKLSFHNLQEEMHHLLEQ 348
Query: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 780
E++ AQA + R S+L+Q+ + E E E+ S + S+ G+
Sbjct: 349 FEQAGQ--------------AQAEL---ESRYSALEQKHKAEME--EKTSHILSLQKTGQ 389
Query: 781 EILIQHSAAETSGDAGEK--PDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQ 838
E+ SA + D K D Q + EDQ++ K + + Q L +
Sbjct: 390 EL---QSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEI------SQFLNR 440
Query: 839 NVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSL-LDGLNQAFEEVSSQSGGAK 897
L+Q + S P DV + AVT + L + E+ ++ G
Sbjct: 441 LPLQQHETASQTSFP------------DVYNEGTQAVTEENIASLQKRVVELENEKGALL 488
Query: 898 RQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEM 957
SI LE+ L E+L LL + T ++E+ I +++
Sbjct: 489 LSSIELEE------------LKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIA--- 533
Query: 958 DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDL 1017
N S + E+G +DV+E+T LS+L +MKE ++I + L
Sbjct: 534 ----NKRSSSAEESG--QDVLENTFSQKHKELSVL-------LLEMKEAQEEIAFLKLQL 580
Query: 1018 KVLFTSLADNKYIILQKLAN------------VFEQPVAEQIEAIQQAEDGLKEF----- 1060
+ AD++ + +++ VF + + + E L
Sbjct: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQA 640
Query: 1061 ---------------DAGII--ELKRRGDKL-----QVEQPSMQELSKLQDMYDELMMII 1098
DAG+ K+ GDK + Q EL +L+ EL +
Sbjct: 641 STEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNF 700
Query: 1099 GSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYF 1158
+ +NL K+ + + +L L+E ++ + + EE QLL + KE
Sbjct: 701 HKAQEIYEKNLDEKA---KEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELS 757
Query: 1159 -------QGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYI 1211
Q + M L E ++ + + + +T L Q ++ A + V++E +
Sbjct: 758 MVTELRAQVKQLEMNLAEAERQRRLDY--ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVL 815
Query: 1212 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP--- 1268
+ LD+ Q + S Q ++ S + + E +++ +H+ S + E
Sbjct: 816 Q---NELDDVQLQFSEQSTLIRSLQSQL---QNKESEVLEGAERVRHISSKVEELSQALS 869
Query: 1269 -------KLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHW 1321
K+ Q+L + KR + ++ +E + Q+ E S T KM +L+ + L
Sbjct: 870 QKELEITKMDQLLLEKKRDVETLQ-QTIEEKDQQVTEISFSMTEKMV-QLNEEKFSLGVE 927
Query: 1322 TRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKE-VDAQSSLK 1380
+ E +L+ + AK ++ V L+ D ++ + SKE + + L
Sbjct: 928 IKTLKEQLNLLSRAEEAKKEQ---VEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLL 984
Query: 1381 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTN----IPAVQEKLHQLQMDKLPS 1436
+ L+ ++ L +SR++ + +L IP + + +++ DK
Sbjct: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
Query: 1437 RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 1496
++ V S Q+ E +K +I K + LQ + K L +
Sbjct: 1045 EYSEKCVTS-------KCQEIEIYLKQTISEKEVE--LQHIR--------KDLEEKLAAE 1087
Query: 1497 SVLQISSQDVESKRSDKTDFAEQLGA-MNKSWQILQGLVT--------EKIQLLE----- 1542
Q + + DKT+ + L A ++++ I+Q L+T + + L++
Sbjct: 1088 EQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVI 1147
Query: 1543 -----GLLESWS-EYENNVQCLKTWFETQEKRLKQ---------QHRIGDQASVQNALKD 1587
G E W E E + L+ E +K+L++ + + ++ LK
Sbjct: 1148 SPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQ 1207
Query: 1588 CQD----LEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRE--------LGQTW 1635
+D L++ + KE E I L +E + + ST ++ L +
Sbjct: 1208 QKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPL 1267
Query: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 1695
+L ++ W SH ++ ++ S+++ + +EA +V+++
Sbjct: 1268 FKATEQHHTQPVLESNLCPDWPSHSE-----DASALQGGTSVAQIKAQLKEIEAEKVELE 1322
Query: 1696 -NLQNLQDDL-EKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 1753
+ + +L +K E Q I Q L+ +LK V+ E + +
Sbjct: 1323 LKVSSTTSELTKKSEEVFQLQEQINKQGLE----------IESLKTVSHEAEVHAESLQQ 1372
Query: 1754 QLQSSK---ALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDC 1810
+L+SS+ A L+ + + + + ++E+ + L + K+ A ++ T I +
Sbjct: 1373 KLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQ 1432
Query: 1811 NDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTS 1870
DL+K L T + H+ E++KQ L LC ++Q
Sbjct: 1433 EDLIKALHTQLEMQAKEHD--ERIKQ----------------LQVELCEMKQ-------- 1466
Query: 1871 LQAGVLDYETFAKSL--EALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFS 1928
+ + E+ AK L+A ++ +E L+ + ++QE + +G + + +
Sbjct: 1467 -KPEEIGEESRAKQQIQRKLQAALISRKEALK--------ENKSLQEELSLARGTIERLT 1517
Query: 1929 SMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 1988
D++ +++ + D + R+ +L+ + + +++ LL++Q+
Sbjct: 1518 KSLADVE--SQVSAQNKEKDTVLGRL-------ALLQEERDKLITEMDRSLLENQSLSSS 1568
Query: 1989 CETW---MEFLVQTEQKLAVEI----SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIID 2041
CE+ +E L + ++KL EI S E Q H+ Q E Q ++ +
Sbjct: 1569 CESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNE 1628
Query: 2042 GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRK 2101
+R+ Q V+ +Q + + ++R + ++ EK
Sbjct: 1629 AERI-----------------------QHVVEAVRQEKQELYGKLRSTEANKKETEK--- 1662
Query: 2102 WLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS--- 2158
LQ+A +E++ K + F + + IL +E L +
Sbjct: 1663 ------------------QLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVH 1704
Query: 2159 --ADSGAEA--ALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLR 2214
D+ E L + A ++E+ + M E KK L+ + + + + D ++
Sbjct: 1705 PAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
Query: 2215 -TFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL-LKDTLSAYISADDIS 2272
K+ + + H+ + +E ++ T++ LS+ + T S S
Sbjct: 1765 GNVSKQANLEATEKHDN---QTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE--SVPSAK 1819
Query: 2273 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWL-----TQMESKV 2327
N V +E+ + L + Q+ ER+ +KNKE + L T +
Sbjct: 1820 SANPAVSKDFSSHDEINNYLQ-QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS 1878
Query: 2328 SQNGDI-LIEEMIEK---LKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 2383
+++G++ +++E + K L + QEE++ +L++ E E +++
Sbjct: 1879 TKDGELKMLQEEVTKMNLLNQQIQEELS----RVTKLKETAEEEKDDLEERLMNQLAELN 1934
Query: 2384 GKVNDRWQHLLD------LIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 2437
G + + Q + D L+ + +K LK+ V +L++ L +ESE+ K +
Sbjct: 1935 GSIGNYCQDVTDAQIKNELLESEMKNLKK---CVSELEEEKQQLVKEKTKVESEIRKEYL 1991
Query: 2438 Y----------DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 2487
+ +++E+Q L E+Q+ + ++K ++ E + + T+
Sbjct: 1992 EKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE 2051
Query: 2488 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSR-----FEDWLKSS 2542
++ D ++ NL A ++E R K + ++ LDD D LK
Sbjct: 2052 SQKD-LEITKENL--------AQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLK 2102
Query: 2543 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHEC----LTQLELINKQYRRLARE--NRT 2596
+ + S V + +K E +R++ + L + + + ++ L RE +
Sbjct: 2103 KELQSNKES------VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLE 2156
Query: 2597 DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 2656
++ ++ +++ ++ LQ+ + S + +L F + RD ++ + + + +
Sbjct: 2157 ETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFS 2216
Query: 2657 NIEHFSECDVQAK----------IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA 2706
+ E +++ K ++Q+ +E+ +N +++E +Q+ E +
Sbjct: 2217 DAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH----DKQIWESKAQTEV 2272
Query: 2707 AIIEEELDELRRYCQEVFGRVER----YHKKLIRLPLPDDEHDLSDRELELED-SAALSD 2761
+ ++ D L+ +E+ ++E YH +++L+ E EL+ L+D
Sbjct: 2273 QLQQKVCDTLQGENKELLSQLEETRHLYHSS---------QNELAKLESELKSLKDQLTD 2323
Query: 2762 LHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 2821
L S++L Q E R A + + ++ L DL++
Sbjct: 2324 L---------------SNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ---LETDLQA 2365
Query: 2822 AMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 2881
SR L S E + K+ + LSG A++ I +L + D +I++ EN++
Sbjct: 2366 --SRELTSRLHEEINMKEQKIISL--LSGKEEAIQVAIAELRQQHDK---EIKELENLLS 2418
Query: 2882 SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST------- 2934
+ L+ K K + + + ++++K ++ + +++ L FV S+
Sbjct: 2419 QEEEENIVLEEENK---KAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDR 2475
Query: 2935 ---------ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNS----IWAWLG 2981
E + ++++ +L+Q +A ++ ++K+ ++ + DLNS + A L
Sbjct: 2476 IVGDYQQLEERHLSIILEKDQLIQ-EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELI 2534
Query: 2982 DTEEELEQLQRLELSTDIQTIELQIKKLKELQ-----------KAVDHRKAIILSINLCS 3030
E+L Q+ ++ S Q +E+Q+++ KEL+ ++ + + + S N
Sbjct: 2535 QYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQ 2594
Query: 3031 PEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 3090
E Q SKE L+ +SQ+ +V +L EE G L Q + E H L +
Sbjct: 2595 EE-KQDLSKEIESLKVSISQLT---RQVTALQEE--GTLGLYHAQLKVKEEEVHRLSALF 2648
Query: 3091 ENIDRR----KNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 3146
+ +R + E+V + ++ + K ++KH L + + + + V
Sbjct: 2649 SSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKH--LHHDAGIMRNETETAEERVA 2706
Query: 3147 AEGTDCLEAKEKVHVIGNRLKLLLKEV---SRHIKELEKLLDVSSSQQD 3192
D +E ++K+ ++ K L ++ R + L+ D ++ + D
Sbjct: 2707 ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELD 2755
Score = 142 bits (358), Expect = 6e-33
Identities = 652/3284 (19%), Positives = 1272/3284 (38%), Gaps = 504/3284 (15%)
Query: 38 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA--------SQLREQ 89
Q+E +LSK +++++ EE E+ ++ K EK ++++ A S E+
Sbjct: 127 QSEEQLSKHDKSST--EEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEE 184
Query: 90 YILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVA-ELGRETEELRQMIKIRL 148
+++ + L+E +E S L+A + Q E+ +QQV E E ++ + L
Sbjct: 185 FVMMKQQLQEKEEFISTLQAQLSQTQ-------AEQAAQQVVREKDARFETQVRLHEDEL 237
Query: 149 QNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM-ESLK 207
L A + + +L+ LQ LE+ + +L VGR + + L + + L
Sbjct: 238 LQLVTQADVETEMQQKLRVLQRKLEEHEESL----VGRAQVVDLLQQELTAAEQRNQILS 293
Query: 208 PKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQY 267
++Q ++ + LR + + + L++ + + N+ + EQ+
Sbjct: 294 QQLQQMEAEHNTLRNTVETERE----ESKILLEKMELEVAERKLSFHNLQEEMHHLLEQF 349
Query: 268 EQ------EMKHLQQLIEGAHR-EIEDKPVATSNI-------QELQAQI----------- 302
EQ E++ +E H+ E+E+K TS+I QELQ+
Sbjct: 350 EQAGQAQAELESRYSALEQKHKAEMEEK---TSHILSLQKTGQELQSACDALKDQNSKLL 406
Query: 303 -SRHEELAQKIKGYQEQIASLNSKCKMLTM------KAKHATMLLTVTEVEGLAEGTEDL 355
++E+ Q + Q+ L K K ++ +H T T + + EGT+ +
Sbjct: 407 QDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQT-SFPDVYNEGTQAV 465
Query: 356 DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDAS 415
E + S VV + + LLS + E + S + + D
Sbjct: 466 TEENI--ASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523
Query: 416 VNQ----DIAYYQALSAER-----LQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQ- 465
V++ DIA ++ SAE L+ ++ H S + E A KL LQ
Sbjct: 524 VSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL-QLQG 582
Query: 466 -RSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQM 524
R+ E V+ +K+ E E + + T + + ES P E
Sbjct: 583 KRAEEADHEVLDQKEMKQMEG-EGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAS 641
Query: 525 AEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMK 584
EHQ+ E + L D EL+S+ + +S A P Q L L ++ + +
Sbjct: 642 TEHQSRTSEEISLNDAGVELKSTKQDG--DKSLSAVPDIGQCHQDELERLKSQILELELN 699
Query: 585 ASGKRQLLEEKLNDQLEE-QRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKE---P 640
+++ E+ L+++ +E Q ++ ++ AD S + D LS KE
Sbjct: 700 FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMV 759
Query: 641 MDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSL 700
++ AQ+ + L E E++ E ++NLL E EA+ K+ L+ L
Sbjct: 760 TELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNEL 819
Query: 701 LELQRALHDKQL---NMQGTAQEKEE------SDVDLTATQSPGVQEWLAQARTTWTQQR 751
++Q ++ ++Q Q KE V +++ + + L+Q T+
Sbjct: 820 DDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMD 879
Query: 752 QSSLQQQKELE--QELAEQK-----------------------SLLRSVASRGEEILIQH 786
Q L++++++E Q+ E+K SL + + E++ +
Sbjct: 880 QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLS 939
Query: 787 SAAETSGDAGEKPDVLSQELGMEGEKSS-----AEDQMRMKWESLHQEFSTKQKLLQNVL 841
A E + E+ + +S L ++ S ++++++ +++ L +E +++ LQ L
Sbjct: 940 RAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAAL 999
Query: 842 EQEQEQVLYSRPNRLLSGVPLYKG----DVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK 897
+E L R +RL + K ++P + D N+ + E + +
Sbjct: 1000 INRKE--LLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSE-KCVTSKCQ 1056
Query: 898 RQSIHLEQKLYDGVSATSTWLDDVEERL-----FVATALLPEETETCLFNQ-EILAKDIK 951
I+L+Q + + D+EE+L F A +T NQ ++L +I
Sbjct: 1057 EIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
Query: 952 EMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQIL 1011
E + K + S +GD+ ++++T+ V++ C E
Sbjct: 1117 E--NQAIIQKLITSNTDASDGDSVALVKETV------------VISPPCTGSSE------ 1156
Query: 1012 NFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRG 1071
+++ +L+ +L K + +KL A ++ Q+ E L+E ELK++
Sbjct: 1157 HWKPELEEKILALEKEKEQLQKKLQEALTSRKA-ILKKAQEKERHLRE------ELKQQK 1209
Query: 1072 DKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 1131
D + ++LQ+ +DE +S N+N+ R LQ + E+
Sbjct: 1210 D----------DYNRLQEQFDE--------QSKENENI---GDQLRQLQ--IQVRESIDG 1246
Query: 1132 KM-AGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTEL 1190
K+ + DQ+ SS +++ L K E + +L L S +
Sbjct: 1247 KLPSTDQQESCSSTPGLEEPLFKATEQH---HTQPVLESNLCPDWPSHSEDASALQGGTS 1303
Query: 1191 MAQASAVLKRAHKRGVELEY-ILETWSHLDEDQQELSR-QLEVVESSIPSVGLVEENEDR 1248
+AQ A LK VELE + T S L + +E+ + Q ++ + + L + +
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1363
Query: 1249 LIDRITLYQHLKSS---------LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 1299
+ +L Q L+SS L E QPKL D + LIS D+ QL E
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLEHLRELQPKL-----DELQKLISKKEEDVSYLSGQLSEK 1418
Query: 1300 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQE---L 1356
+ T ++ + + + I T+ + ++ + ++ + L Q+ + +E
Sbjct: 1419 EAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAK 1478
Query: 1357 EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLL 1416
+ ++ L A L KE ++ LS + A + S++S + + +L
Sbjct: 1479 QQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVL 1538
Query: 1417 TNIPAVQEKLHQL--QMDK--LPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH- 1471
+ +QE+ +L +MD+ L ++ S S +E + + E +K K+
Sbjct: 1539 GRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKI 1598
Query: 1472 ----EYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 1527
E+ +K+K + + + + V+ +I VE+ R +K + +L + +
Sbjct: 1599 AESTEWQEKHKELQKEYEILLQSYENVSNEAERI-QHVVEAVRQEKQELYGKLRSTEANK 1657
Query: 1528 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQ-HRIGDQASVQNALK 1586
+ + + E Q +E + E ++ + Q E + RL+ + H GD A K
Sbjct: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTA------K 1711
Query: 1587 DCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLK 1646
+C +E L+ + E++E+ + K+ S +MS L + +L H + +
Sbjct: 1712 EC--METLLSSNASMKEELERVKMEYETLSKKFQS--LMSEKDSLSEEVQDLKHQI-EGN 1766
Query: 1647 ILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEK 1706
+ ++ L+ H V + Q++ + E+
Sbjct: 1767 VSKQANLEATEKHD---------------------------NQTNVTEEGTQSIPGETEE 1799
Query: 1707 QE---RSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQ 1763
Q+ S + S + K +P V++ ++ + NN L++I + + L +
Sbjct: 1800 QDSLSMSTRPTCSESVPSAKSANPAVSKDFSS-----HDEINNYLQQIDQLKERIAGLEE 1854
Query: 1764 LWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDS 1823
Q+ K++S Q E+ N LL + KD L +++
Sbjct: 1855 EKQKNKEFS-------QTLENEKNTLLSQISTKD-----------------GELKMLQEE 1890
Query: 1824 LFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAK 1883
+ ++ L +Q+++++ S + + + + LE+ L Q L + +Y
Sbjct: 1891 VTKMNLLNQQIQEEL-----SRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY----- 1940
Query: 1884 SLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF-SSMAPDLDRLNELGY 1942
+ +A I E+L+ + + +S ++E ++L + K S + + +
Sbjct: 1941 CQDVTDAQI--KNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQ 1998
Query: 1943 RLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ---TFLEKCETWMEFLVQT 1999
+ P N K +Q L + + + +LQ +++Q + LE+ +EF VQT
Sbjct: 1999 KEPGNKSHAKELQELLK-------EKQQEVKQLQKDCIRYQEKISALERTVKALEF-VQT 2050
Query: 2000 EQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL 2059
E + +EI+ ++L + + QAE+ S + +L + R+L D L
Sbjct: 2051 ESQKDLEIT--KENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVL-------ADNLKL 2101
Query: 2060 KLTLLSNQWQGVIRRAQQR-----RGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 2114
K L SN+ + V + +Q+ R + ++ + + + M EKL E +L + +
Sbjct: 2102 KKELQSNK-ESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEET-I 2159
Query: 2115 GSVPIPL-------QQARTLFDEVQFKEKVFLRQQGSY-----ILTVEAGKQLLLSADSG 2162
G + + L QQ + D + F + S + EA K +D+
Sbjct: 2160 GEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAI 2219
Query: 2163 AEAALQAELAE-----IQEKWKSASMRLEEQKKKLAFLLKD---WEKCEKGIADSLEK-- 2212
+ L E ++++ + S+ +EE K ++ L D WE + +K
Sbjct: 2220 QSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVC 2279
Query: 2213 --LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLS-------LLKDTLS 2263
L+ K+L L + H+ Q +LE+ + S D LT LS K L
Sbjct: 2280 DTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLE 2339
Query: 2264 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 2323
I + I N + +E+L L R ++ RL+E + K +++ L+
Sbjct: 2340 GIIRQQEADIQNSKF-----SYEQLETDLQASR-ELTSRLHE--EINMKEQKIISLLSGK 2391
Query: 2324 E-------SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENK------IQLQQMGERLAKA 2370
E +++ Q D I+E+ L ++ +E I + +ENK QL + + + K
Sbjct: 2392 EEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKE 2451
Query: 2371 SHESKA---SEIEYKLGKVNDR------WQHL----LDLIAARVKKLKETLVAVQQLDKN 2417
+ + KA S ++ NDR +Q L L +I + + ++E +L +
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511
Query: 2418 MSSLRTWLAHIESELAK---------------PIVYDSCNSEEIQRKLNEQQELQRDIEK 2462
+ LR+ + + SE AK + DS + ++ +L + +EL+ K
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAK 2571
Query: 2463 HSTGVASVLNLCEVLLHDCDACATDAE--CDSIQQATRNLDRRWRNICAMSME------- 2513
+ E L +A + + I+ ++ + R + A+ E
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH 2631
Query: 2514 --RRLKIEETWRLWQKFLDDYSR---FEDWLKSSERTAAFPSSSGVIYTVAKEELK---- 2564
++K EE RL F R E+ L ++ AA G I K+ELK
Sbjct: 2632 AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA--KKVGEIEDKLKKELKHLHH 2689
Query: 2565 -------KFEAFQRQVHECLTQLELINKQYRRLARENR---------TDSACSLKQMVHE 2608
+ E + +V E L + ++ + +EN+ S SL+
Sbjct: 2690 DAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDH 2749
Query: 2609 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQA 2668
N+ D L+++ + L+ L + ++ RD++ L+E + + E S
Sbjct: 2750 ANEELDELKRKYDASLKELAQ-LKEQGLLNRERDAL---LSETAFSMNSTEENS------ 2799
Query: 2669 KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVE 2728
+ L+ Q++ +K EQ++ QL + + + + + L+ ++ +E
Sbjct: 2800 -LSHLEKLNQQLL---SKDEQLLHLSSQLEDSYNQVQS--FSKAMASLQNERDHLWNELE 2853
Query: 2729 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQP---SSNLSLSL 2785
++ K + S E++ A S + DR L + Q N ++
Sbjct: 2854 KFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITE 2913
Query: 2786 AQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE-EGQDDKDFYLRG 2844
PL+++ I E +LS E R S E + K+ YL
Sbjct: 2914 LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMA 2973
Query: 2845 AVGLSGDHSALESQIRQLGKALDDSRFQIQQTENI-IRSKTPTGPELDTSYKGYMKLLGE 2903
S L++ IR+L R QT+ + ++ + PE S G L+ E
Sbjct: 2974 ISDKDQQLSHLQNLIREL-------RSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYE 3026
Query: 2904 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL-RMKQN 2962
+L LKE + L+S +Q L + LS +L Q+
Sbjct: 3027 TEL---LRTQLNDSLKEIHQKELRIQQLNSNFSQL--------LEEKNTLSIQLCDTSQS 3075
Query: 2963 LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAI 3022
L++ QQ DL + A L E+++++LQ L+ D+ Q +K HRK+
Sbjct: 3076 LRENQQHYGDLLNHCAVL---EKQVQELQAGPLNIDVAPGAPQ-------EKNGVHRKS- 3124
Query: 3023 ILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWR 3066
PE + + + Q +L + + LLEE R
Sbjct: 3125 -------DPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEER 3161
Score = 130 bits (327), Expect = 2e-29
Identities = 578/3038 (19%), Positives = 1181/3038 (38%), Gaps = 437/3038 (14%)
Query: 307 ELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH 366
+L QK + QE+ + ++K K L + AK L E A+G G +LPT
Sbjct: 74 QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQG-----GTVLPTEP-- 126
Query: 367 PSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQAL 426
+ LS + S EE E ++ A + Q A A
Sbjct: 127 ---------QSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQ 177
Query: 427 SAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEAL 486
S+ ++ + + +EF + A+L Q + + V+ EK +
Sbjct: 178 SSTEME-EFVMMKQQLQEKEEFIS-----TLQAQLSQTQAE-QAAQQVVREKDARFETQV 230
Query: 487 ERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALM----DEILMLQDEIN 542
+ ++D L + T+ + +E + R + ++ EH+ + + +LQ E+
Sbjct: 231 ---RLHEDELLQLVTQADV----ETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELT 283
Query: 543 ELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEE 602
+ +++S+ + AE L++T+ E + K + ++ E KL+ +
Sbjct: 284 AAEQ--RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM--ELEVAERKLSFHNLQ 339
Query: 603 QRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 662
+ L+++ +A + + L S + L+ K +ME + ++ ++
Sbjct: 340 EEMHHLLEQFE-QAGQAQAELESRYSALE-----QKHKAEMEEKTSHILSLQKTGQELQS 393
Query: 663 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE 722
A L N LL + A+ + +L+ E+ + L+ L TA +
Sbjct: 394 ACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTS 453
Query: 723 ESDVDLTATQSPGVQEWLA--QARTTWTQQRQSS-------LQQQKELEQELAEQKSLLR 773
DV TQ+ +E +A Q R + + + L++ K ++L+ Q +LL
Sbjct: 454 FPDVYNEGTQAV-TEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLE 512
Query: 774 SVASRGE------EILIQHSAAETSGDAGEK-PDVLSQELGMEGEKSSAEDQMRMKWESL 826
+ GE EI I A + S A E DVL + ++ S + ++ +
Sbjct: 513 AQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSV---LLLEMKEA 569
Query: 827 HQEFS-TKQKLLQNVLEQEQEQVLYSRPNRLL--SGVPLYKGDVPTQDKSAVTSLLDGLN 883
+E + K +L E+ +VL + + + G+ K V +D L+
Sbjct: 570 QEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEE 629
Query: 884 QAFEEVSSQSGGAKRQS------------IHLEQKLYDGVSATSTWLD------DVEERL 925
+ V + + QS + L+ DG + S D D ERL
Sbjct: 630 SSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERL 689
Query: 926 FVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL 985
L QEI K++ E ++E+ N N + F +N DN
Sbjct: 690 KSQILELELNFHKA---QEIYEKNLDEKAKEI-SNLNQLIEEFKKNADNNS--------- 736
Query: 986 LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSL--ADNKYIILQKLANVFEQPV 1043
+ L +Q Q+KE L + + +K L +L A+ + + + + +
Sbjct: 737 -SAFTALSEERDQLLSQVKE-LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLL 794
Query: 1044 AEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRS 1103
EQI ++ IE K + K++V Q EL +Q + E +I S +S
Sbjct: 795 TEQIHSLS-------------IEAKSKDVKIEVLQ---NELDDVQLQFSEQSTLIRSLQS 838
Query: 1104 GL-NQNLTLKSQYERA------LQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKE 1156
L N+ + ER +++L+ L + ++ ++++ K +++ L +E
Sbjct: 839 QLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEE 898
Query: 1157 YFQGL-ESHMILTETLFR---KIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYIL 1212
Q + E +TE + + + S V+ +T L Q + + + + ++E
Sbjct: 899 KDQQVTEISFSMTEKMVQLNEEKFSLGVEIKT-----LKEQLNLLSRAEEAKKEQVEEDN 953
Query: 1213 ETWSHLDEDQQELSRQLEVVESSIPSVG--LVEENEDR-------LIDRITLYQHLKSSL 1263
E S L ++ E+S ++ + + L +ENE R LI+R L Q +
Sbjct: 954 EVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQR----V 1009
Query: 1264 NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNK------MSKELHRLETI 1317
+ + +L + D+ K+ I S+ E GE NK ++ + +E
Sbjct: 1010 SRLEEELANLKDESKK---EIPLSETER-----GEVEEDKENKEYSEKCVTSKCQEIEIY 1061
Query: 1318 LKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQS 1377
LK + +L H + +++L Q V Q + ++D N E+
Sbjct: 1062 LKQ--TISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQ 1119
Query: 1378 SLKSSVL------STGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQM 1431
++ ++ S G+ + +K +T + + W P ++EK+ L+
Sbjct: 1120 AIIQKLITSNTDASDGDSVALVK--ETVVISPPCTGSSEHWK------PELEEKILALEK 1171
Query: 1432 DKLPSRHAISEVMSWISLMENVIQKDEDNIKNSI-----GYKAIHEYL--QKYKGFKIDI 1484
+K + + E ++ + Q+ E +++ + Y + E Q + I
Sbjct: 1172 EKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGD 1231
Query: 1485 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 1544
+QL + ++ S D + S E L ++ + T+ + L L
Sbjct: 1232 QLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPL------FKATEQHHTQPV-LESNL 1284
Query: 1545 LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEV-- 1602
W + + L+ T ++K Q + + V+ LK +L K K +EV
Sbjct: 1285 CPDWPSHSEDASALQG--GTSVAQIKAQLKEIEAEKVELELKVSSTTSELTK-KSEEVFQ 1341
Query: 1603 --EKIEQNGLAL----------------IQNKKEDVSSIV--MSTLRELGQTWANLDHMV 1642
E+I + GL + +Q K E + + LREL L ++
Sbjct: 1342 LQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLI 1401
Query: 1643 GQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD-NLQNLQ 1701
+ + + + Q S + A KI + ++E + L LE + D ++ LQ
Sbjct: 1402 SKKEEDVSYLSGQLSEKEAALTKIQTEIIEQE---DLIKALHTQLEMQAKEHDERIKQLQ 1458
Query: 1702 DDLEKQERSLQKFG--SITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSK 1759
+L + ++ ++ G S Q ++ + LKE N L+E E +
Sbjct: 1459 VELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE-----NKSLQE--ELSLARG 1511
Query: 1760 ALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGT 1819
+ +L + D Q ++ ++++ L +D E+ + + L +
Sbjct: 1512 TIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES 1571
Query: 1820 VKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYE 1879
+K +L L E E+L +++++ +S I +H + L K+ L +
Sbjct: 1572 LKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKH-----KELQKEYEILLQSYENVS 1626
Query: 1880 TFAKSLEALEAWIVEAEEILQGQDPSHSSD-------LSTIQERMEELKGQMLKFS-SMA 1931
A+ ++ + + + ++ L G+ S ++ L ++ MEE+K +M KF+ S
Sbjct: 1627 NEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQ 1686
Query: 1932 PDLDRLNELGYRL-----PLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFL 1986
+ L E RL P D + M+ +L+SS + + +L+ ++++T
Sbjct: 1687 QKILELEEENDRLRAEVHPAGDTAKECME------TLLSSNASMK-EELERVKMEYETLS 1739
Query: 1987 EKCETWM---EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQ 2043
+K ++ M + L + Q L +I GN + L E Q ++ +G
Sbjct: 1740 KKFQSLMSEKDSLSEEVQDLKHQIEGNV------SKQANLEATEKHDNQT---NVTEEGT 1790
Query: 2044 RLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL 2103
+ + G+ +++D ++ ++ + A S + Y + ++L++
Sbjct: 1791 QSI-PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKE-- 1847
Query: 2104 VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA 2163
++GL +E + K K F + T+E K LLS S
Sbjct: 1848 ------RIAGL--------------EEEKQKNKEFSQ-------TLENEKNTLLSQISTK 1880
Query: 2164 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223
+ EL +QE+ ++ ++ +++L+ + K E E+ D E+L +L+ S
Sbjct: 1881 D----GELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGS 1936
Query: 2224 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 2283
+ ++ +++ Q++ + LE+ + + +++L K L + + I E +E +Q
Sbjct: 1937 IGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQG 1996
Query: 2284 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 2343
+E ++ + Q E L E Q E K Q I +E I L+
Sbjct: 1997 AQKEPGNKSHAKELQ--ELLKE---------------KQQEVKQLQKDCIRYQEKISALE 2039
Query: 2344 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 2403
+ + + E++ L+ E LA+A K ++ E KV L D + +
Sbjct: 2040 RTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKV-----LLDDTQSEAARV 2094
Query: 2404 LKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKH 2463
L + L ++L N S+++ + + +L + + + + ++ K N Q++L + +
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRL--EQAEEKHLKEKKNMQEKLDA-LRRE 2151
Query: 2464 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSM-------ERRL 2516
+ + +V L+ D +QQ NLD + A + +R
Sbjct: 2152 KVHLEETIGEIQVTLNKKD--------KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDR 2203
Query: 2517 KIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK----KFEAFQRQ 2572
I+E + +KF D E+ ++ E + ++ EELK + E +Q
Sbjct: 2204 VIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLE-HDKQ 2262
Query: 2573 VHE--CLTQLELINKQYRRLARENR--TDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 2628
+ E T+++L K L EN+ + + H L+ + S+ +L
Sbjct: 2263 IWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLT 2322
Query: 2629 HFIGQREEFETARDSI--LVWLTEMDLQLTNIEHFS-ECDVQAKIKQLKAFQQEISLNHN 2685
E+ + + ++ ++ E D+Q + + E D+QA + +EI++
Sbjct: 2323 DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQ 2382
Query: 2686 KIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 2745
KI +++ E+ I+ + + ELR+ + ++ K+L L ++E +
Sbjct: 2383 KIISLLSGKEEAIQVA-----------IAELRQ-------QHDKEIKELENLLSQEEEEN 2424
Query: 2746 LSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL-SLAQPLRSERSGRDTPASVDS 2804
+ LE E+ A+ + + ++ L S + + S ++ RD D
Sbjct: 2425 I---VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG-DY 2480
Query: 2805 IPLEWDHDYDLSRDLE-SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLG 2863
LE H LS LE + + +E+ + +++ L+ +++ L++++ Q
Sbjct: 2481 QQLEERH---LSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYR 2537
Query: 2864 KALDD-SRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 2922
+ L+ + Q + ++ + EL+ Y + L E + + ++R + L+EE+
Sbjct: 2538 EDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEK 2597
Query: 2923 ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE-------LRMKQNLQKWQQFNSDLNS 2975
+ L S E ++ V Q AL +E ++K ++ + ++ +S
Sbjct: 2598 QDL-------SKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSS 2650
Query: 2976 IWAWLGDTEEELEQLQRLELSTDIQTIELQIKK-LKELQKAVDHRKAIILSINLCSPEFT 3034
+ + EEEL +Q+ E + + IE ++KK LK L H A I+ T
Sbjct: 2651 SQKRIAELEEELVCVQK-EAAKKVGEIEDKLKKELKHL-----HHDAGIMR------NET 2698
Query: 3035 QADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 3094
+ + +L L +M ++ + +E +GL Q Q F + + + D
Sbjct: 2699 ETAEERVAELARDLVEME---QKLLMVTKENKGL----TAQIQSF---GRSMSSLQNSRD 2748
Query: 3095 RRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE 3154
E+ + DA + K+L Q+K + L ++ R A L + + + N+ + L
Sbjct: 2749 HANEELDELKRKYDASL-----KELAQLKEQGLLNRERDALLSETAFSM--NSTEENSLS 2801
Query: 3155 AKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD 3192
EK++ +LL K+ E+LL +SS +D
Sbjct: 2802 HLEKLN-----QQLLSKD--------EQLLHLSSQLED 2826
Score = 125 bits (315), Expect = 5e-28
Identities = 435/2222 (19%), Positives = 875/2222 (39%), Gaps = 366/2222 (16%)
Query: 1 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
+E D V L+QN P A +I K H+ + + EN K A+ + E+L
Sbjct: 949 VEEDNEVSSGLKQNYDEMSP-AGQISKEELQHEFDLLKKENEQRKRKLQAALINR-KELL 1006
Query: 61 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL---LEESKEIDSELE-AMTEKLQY 116
+ + + E+ N + +++ L +T +EE KE E +T K Q
Sbjct: 1007 QRVSRLEEELA---------NLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQE 1057
Query: 117 LTSVYCTEKMSQQVAELGRETEELRQ----------MIKIRLQNLQDAAKDMKKFEAELK 166
+ +Y + +S++ EL ++L + ++K Q LQD + +AE+
Sbjct: 1058 I-EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
Query: 167 KLQAALEQAQATLTSPEVGR--LSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPE 224
+ QA +++ + T G +KE + E KP+++
Sbjct: 1117 ENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELE------------- 1163
Query: 225 DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHRE 284
L L++E +LQ +Q+ + A+++ Q ++ +HL++ E
Sbjct: 1164 ---------EKILALEKEKEQLQ-KKLQEALTSRKAILKKAQ--EKERHLRE-------E 1204
Query: 285 IEDKPVATSNIQE-LQAQISRHEELAQKIKGYQEQI-ASLNSKCKMLTMKAKHATMLLTV 342
++ + + +QE Q +E + +++ Q Q+ S++ K L
Sbjct: 1205 LKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGK--------------LPS 1250
Query: 343 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 402
T+ + T L+ L H + ++ + C S + S +G
Sbjct: 1251 TDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQG---------- 1300
Query: 403 CRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLG 462
SV Q A + + AE+++ + K+ +TS + E +
Sbjct: 1301 ----------GTSVAQIKAQLKEIEAEKVELE-LKVSSTTSELTKKSEEVFQLQEQINKQ 1349
Query: 463 DLQRSWETLKNVISEKQ---RTLYEALERQQKY---QDSLQSISTKMEAIELKLSESPEP 516
L+ E+LK V E + +L + LE Q + L+ + K++ ++ +S+ E
Sbjct: 1350 GLE--IESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407
Query: 517 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 576
Q++E +A + +I E +L +L +L ++ E D + LQ L + +
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIK-QLQVELCEMKQ 1466
Query: 577 RMSTIRMKASGKRQL---LEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTA 633
+ I ++ K+Q+ L+ L + E ++ ++LQ A L + A +++
Sbjct: 1467 KPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQ 1526
Query: 634 LSPPKEPMDME----AQLMDCQNMLV-EIEQKVVALSELSVHNENLLLEGKAHTKDEAEQ 688
+S + D A L + ++ L+ E+++ ++ LS E+L L + T+D+ E+
Sbjct: 1527 VSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK-EK 1585
Query: 689 LAGKLRRLKGSLL-----------ELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ 737
L ++ LK S + ELQ+ + + + E E + A + Q
Sbjct: 1586 LVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQE-KQ 1644
Query: 738 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQ------------ 785
E + R+T ++++ Q Q E EQE+ E K +R A ++ +++
Sbjct: 1645 ELYGKLRSTEANKKETEKQLQ-EAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV 1703
Query: 786 HSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFST------------- 832
H A +T+ + E +LS M+ E ++++M++E+L ++F +
Sbjct: 1704 HPAGDTAKECME--TLLSSNASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQ 1757
Query: 833 --KQKLLQNVLEQ---EQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFE 887
K ++ NV +Q E + ++ N G G+ QD ++++
Sbjct: 1758 DLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPS 1817
Query: 888 EVSSQSGGAKRQSIHLEQKLY----DGVSATSTWLDDVEERLFVATALLPEETETCLFNQ 943
S+ +K S H E Y D + L++ +++ + L E T L
Sbjct: 1818 AKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQI 1877
Query: 944 EILAKDIKEMSEEMDKNKNLFSQAFPEN-----------GDNRDVIEDTLGCLLGRLSLL 992
++K + EE+ K NL +Q E + +D +E+ L+ +L+ L
Sbjct: 1878 STKDGELKMLQEEVTK-MNLLNQQIQEELSRVTKLKETAEEEKDDLEER---LMNQLAEL 1933
Query: 993 DSVVNQRCHQMKE---RLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEA 1049
+ + C + + + + + + +LK + L + K ++++ V + E +E
Sbjct: 1934 NGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEK 1993
Query: 1050 IQ--QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQ 1107
IQ Q E G K + EL L+ +Q +++L K Y E + + L
Sbjct: 1994 IQGAQKEPGNKSHAKELQEL------LKEKQQEVKQLQKDCIRYQEKISALERTVKALEF 2047
Query: 1108 NLT-LKSQYERALQDLADLLE---TGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES 1163
T + E ++LA +E Q ++A + ++ ++ E ++L + + + L+S
Sbjct: 2048 VQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQS 2107
Query: 1164 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ 1223
+ + S QK+ L LK +L+ + HL+E
Sbjct: 2108 NK-------ESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG 2160
Query: 1224 ELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR---- 1279
E+ L + + ++EN D + ++ + SSL + + + V+D+ K+
Sbjct: 2161 EIQVTLNKKDKEVQQ---LQENLDSTVTQLAAFTKSMSSLQDDRDR---VIDEAKKWERK 2214
Query: 1280 ------------LLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSE 1327
L +CS L+ QL Q+ + ++ + RLE + W +S+
Sbjct: 2215 FSDAIQSKEEEIRLKEDNCSVLKDQLRQMS----IHMEELKINISRLEHDKQIW---ESK 2267
Query: 1328 SADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHL--NAFLEFSKEVDAQSSLKSSVLS 1385
+ + Q D L+ ++ ++ +LE R HL ++ E +K SLK +
Sbjct: 2268 AQTEVQLQQKVCDTLQGENKELLS---QLEETR-HLYHSSQNELAKLESELKSLKDQLTD 2323
Query: 1386 TGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMS 1445
N L + K+ + L I Q + N E QL+ D SR S +
Sbjct: 2324 LSNSLEKCKE-----QKGNLEGIIRQQEADIQNSKFSYE---QLETDLQASRELTSRLHE 2375
Query: 1446 WISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQD 1505
I++ E I + +I AI E Q++ D K+L + I ++
Sbjct: 2376 EINMKEQKIISLLSGKEEAI-QVAIAELRQQH-----DKEIKELENLLSQEEEENIVLEE 2429
Query: 1506 VESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ---LLEGLLESWSEYENNVQCLKTWF 1562
K DKT N+ + L+ + E IQ L+ ++S S +N+ + +
Sbjct: 2430 ENKKAVDKT---------NQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDY 2480
Query: 1563 ETQEKR-----LKQQHRIGDQASVQNALKD--------------------------CQDL 1591
+ E+R L++ I + A+ N LK+ +DL
Sbjct: 2481 QQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDL 2540
Query: 1592 EDLIKAKEKEVEKIEQNGLALIQNKK-EDVSSIVMSTLRELGQTWANLDHMVGQLKILLK 1650
+I K+ + +++ + + L QNK+ E+ + + L+E + +L L+ +
Sbjct: 2541 NQVITIKDSQQKQLLE--VQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
Query: 1651 SVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEK---- 1706
+ + S KV+ ++ + A L L+ + +V L L +K
Sbjct: 2599 DLSKEIESLKVSISQLTRQ-VTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657
Query: 1707 --------QERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSS 1758
Q+ + +K G I ++L KE L + + + N + +
Sbjct: 2658 LEEELVCVQKEAAKKVGEIEDKLKKE--------LKHLHHDAGIMRNETETAEERVAELA 2709
Query: 1759 KALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLG 1818
+ L+++ Q+ +K+ Q + + ++D A++E+ + + LK L
Sbjct: 2710 RDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELA 2769
Query: 1819 TVKDSLFFLHELGEQLKQQVDASAASAIQSDQLS----LSQHLCALEQALCKQQTSLQAG 1874
+K+ E L + A + ++ + + LS L+Q L + ++ L + L+
Sbjct: 2770 QLKEQGLLNRERDALLSE--TAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDS 2827
Query: 1875 VLDYETFAKSLEALE-----AWIVEAEEILQGQDPSHSS--DLSTIQERMEELKGQMLKF 1927
++F+K++ +L+ W E E+ + ++ S ST ++ LK M
Sbjct: 2828 YNQVQSFSKAMASLQNERDHLW-NELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAM--- 2883
Query: 1928 SSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLE 1987
SS+ D DRL +K ++NL + + I+ + TE L Q Q + +
Sbjct: 2884 SSLQNDRDRL-------------LKELKNLQQQYLQINQEITE----LHPLKAQLQEYQD 2926
Query: 1988 KCETWMEFLVQTEQKLAVEISGNYQHLLEQQR----AHELFQAEMFSRQQILHSIIIDGQ 2043
K + F + E+ +S +QH L Q R + E+ + M ++Q L +I Q
Sbjct: 2927 KTKA---FQIMQEELRQENLS--WQHELHQLRMEKSSWEIHERRM--KEQYLMAISDKDQ 2979
Query: 2044 RL 2045
+L
Sbjct: 2980 QL 2981
Score = 76.6 bits (187), Expect = 4e-13
Identities = 267/1330 (20%), Positives = 523/1330 (39%), Gaps = 210/1330 (15%)
Query: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
E D ++ + Q +L + +T+ + E+ + L + S LEE + L
Sbjct: 1918 EKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN-ELLESEMKNLKKCVSELEEEKQQLV 1976
Query: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
EK KV + + Q ++ +++ +E +E+ E + ++LQ Y
Sbjct: 1977 K-----EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRY 2031
Query: 122 CTEKMS---QQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQAT 178
EK+S + V L E ++ ++I +NL A + KK +AEL + L+ Q+
Sbjct: 2032 -QEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSE 2090
Query: 179 LTSPEVGRLSLKEQL-SHRQHLLSEM----ESLKPKVQAVQLCQSALRIPEDVVASL-PL 232
L LK++L S+++ + S+M E L+ +++ + + L+ +++ L L
Sbjct: 2091 AARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE--EKHLKEKKNMQEKLDAL 2148
Query: 233 CHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVAT 292
+ L+E +Q T ++ K +QQL E + T
Sbjct: 2149 RREKVHLEETIGEIQVT-----------------LNKKDKEVQQLQENLDSTVTQLAAFT 2191
Query: 293 SNIQELQAQISRHEELAQK--------IKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 344
++ LQ R + A+K I+ +E+I C +L + + ++
Sbjct: 2192 KSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSI-----H 2246
Query: 345 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 404
+E L L+ + S + V + C TL +G N E+ S
Sbjct: 2247 MEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTL----------QGENKELLS----- 2291
Query: 405 SPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL 464
+ S ++A ++ + L+ + S +E + LE + D+
Sbjct: 2292 QLEETRHLYHSSQNELAKLES-ELKSLKDQLTDLSNSLEKCKE-QKGNLEGIIRQQEADI 2349
Query: 465 QRSWETLKNVISEKQ--RTLYEAL--ERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP 520
Q S + + + ++ Q R L L E K Q + +S K EAI++ ++E +
Sbjct: 2350 QNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE 2409
Query: 521 ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMST 580
++ + +E ++ +E N+ +L+ E+ + E + ++ L + MS+
Sbjct: 2410 IKELENLLSQEEEENIVLEEENKKAVDKTNQLM-ETLKTIKKENIQQKAQLDSFVKSMSS 2468
Query: 581 I---RMKASGKRQLLEEK------LNDQL------EEQRQEQALQRYRCEADELDSWLLS 625
+ R + G Q LEE+ DQL E + ++ ++ R D+L+ S
Sbjct: 2469 LQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLN----S 2524
Query: 626 TKATLDTALSPPKEPMDMEAQLMDC-QNMLVEIEQKVVALSELSVHNENLLLEGKAHTKD 684
A LD L +E ++ + D Q L+E++ + + N+ LE K +
Sbjct: 2525 ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ----QNKELENKYAKLEEKLKESE 2580
Query: 685 EA-EQLAGKLRRLKGSLLELQRALHD-----KQLNMQGTAQEKEESDVDLTATQSPGVQE 738
EA E L L+ +L + + QL Q TA + EE + L Q +E
Sbjct: 2581 EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQ-EEGTLGLYHAQLKVKEE 2639
Query: 739 WLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEK 798
+ + ++ SS ++ ELE+EL + +Q AA+ GE
Sbjct: 2640 EVHRLSALFS----SSQKRIAELEEEL----------------VCVQKEAAK---KVGEI 2676
Query: 799 PDVLSQELG--------MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLY 850
D L +EL M E +AE+++ +L ++++E EQ+ ++
Sbjct: 2677 EDKLKKELKHLHHDAGIMRNETETAEERV--------------AELARDLVEMEQKLLMV 2722
Query: 851 SRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDG 910
++ N+ L+ G + S++ + D N+ +E+ + + ++ L+++
Sbjct: 2723 TKENKGLTAQIQSFG----RSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ---- 2774
Query: 911 VSATSTWLDDVEERLFVATALLPEETETC------LFNQEILAKD--IKEMSEEMDKNKN 962
L+ + L TA TE NQ++L+KD + +S +++ + N
Sbjct: 2775 -----GLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYN 2829
Query: 963 ---LFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKV 1019
FS+A + RD + + L + + + Q ++ LK
Sbjct: 2830 QVQSFSKAMASLQNERDHLWNE----LEKFRKSEEGKQRSAAQPSTSPAEV----QSLKK 2881
Query: 1020 LFTSLADNKYIILQKLANVFEQ--PVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVE 1077
+SL +++ +L++L N+ +Q + ++I + + L+E+ + ++L+ E
Sbjct: 2882 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2941
Query: 1078 QPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQ 1137
S Q EL + + S +K QY A+ D L Q +
Sbjct: 2942 NLSWQH---------ELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI---- 2988
Query: 1138 KIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAV 1197
+ + SS + Q L K +Q S ET S + ET+ L Q +
Sbjct: 2989 RELRSSSSQTQPL----KVQYQRQAS----PETSASPDGSQNLVYETEL---LRTQLNDS 3037
Query: 1198 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQ 1257
LK H++ + ++ + +S L E++ LS QL S+ EN+ D +
Sbjct: 3038 LKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSL------RENQQHYGDLLNHCA 3091
Query: 1258 HLKSSLNEYQ 1267
L+ + E Q
Sbjct: 3092 VLEKQVQELQ 3101
Score = 51.6 bits (122), Expect = 1e-05
Identities = 107/668 (16%), Positives = 262/668 (39%), Gaps = 71/668 (10%)
Query: 5 AAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAEN---RLSKLNQAASHLEEYNEM-- 59
A +++ L+++ + + L + L E Q ++ E+ +S+L + + L+E +
Sbjct: 2570 AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGL 2629
Query: 60 --LELILKWIEKAKVLAHGTIAWNSASQLREQYI-LHQTLLEESKEIDSELEAMTEKLQY 116
+L +K E ++ A + + ++L E+ + + + ++ EI+ +L+ + L +
Sbjct: 2630 YHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHH 2689
Query: 117 LTSVYC--TEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 174
+ TE ++VAEL R+ E+ Q + + + + ++ F + LQ + +
Sbjct: 2690 DAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDH 2749
Query: 175 AQATLTS---------PEVGRLSLKEQLSH-RQHLLSEMESLKPKVQAVQLCQSALRIPE 224
A L E+ +L + L+ R LLSE + L +
Sbjct: 2750 ANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQ 2809
Query: 225 DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHRE 284
+ L H + +L++ +++Q + ++ + + E++ ++ EG R
Sbjct: 2810 LLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQN----ERDHLWNELEKFRKSEEGKQRS 2865
Query: 285 IEDKPVATSNIQELQAQISR----HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLL 340
+ + +Q L+ +S + L +++K Q+Q +N +
Sbjct: 2866 AAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE--------------- 2910
Query: 341 TVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSP 400
+TE+ L ++ + + H L E+S E +
Sbjct: 2911 -ITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKE- 2968
Query: 401 PACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAK 460
+ +++ D ++ + L + QT K+ AS E P +
Sbjct: 2969 ---QYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPE---TSASPDGSQ- 3021
Query: 461 LGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP 520
+L E L+ +++ + +++ R Q+ + + + + ++L ++ + R
Sbjct: 3022 --NLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLREN 3079
Query: 521 ESQMAEHQALMDEILMLQDEINELQSS---------LAEELVSESCEADPAEQLALQSTL 571
+ + L++ +L+ ++ ELQ+ +E ++DP E Q +
Sbjct: 3080 QQHYGD---LLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSF 3136
Query: 572 TVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR-----QEQALQRYRCEADELDSWLLST 626
+ +++ R + + R+LLEE+ + ++ + +EQ + E D + ++ +
Sbjct: 3137 SEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGS 3196
Query: 627 KATLDTAL 634
T + AL
Sbjct: 3197 CGTQEQAL 3204
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 147 bits (370), Expect = 2e-34
Identities = 430/2235 (19%), Positives = 869/2235 (38%), Gaps = 314/2235 (14%)
Query: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
++EL L D+ EL + G + L ++++ +Q+ AD+LE +K A +
Sbjct: 133 IEELRHLWDLLLELTLEKGDQ-------LLRALKFQQYVQECADILEWIGDKEAIATSVE 185
Query: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTEL------MAQA 1194
+ E ++L K E FQ ++ E ++ +A + + H +L +
Sbjct: 186 LGEDWERTEVLHKKFEDFQ---VELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
Query: 1195 SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT 1254
+A +R ++ + L ++L +++++ ++ ++ P + + +D +
Sbjct: 243 NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302
Query: 1255 LYQH--LKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELH 1312
+ H L+ +L K+ ++ ++L +S Q+ ++ E +S+ + +
Sbjct: 303 FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSD--APQIQEMKEDLVSSW----EHIR 356
Query: 1313 RLETILKHWTRYQSESADL-IHWLQSAKDRLEFWTQQSVTVPQELEMVRDH------LNA 1365
L T +RY+ A H S D L W + E+ D L+
Sbjct: 357 ALAT-----SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
Query: 1366 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEK 1425
+ E+D+ S TG L+ + +R ++ +D+ WT LL +
Sbjct: 412 HQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQ 471
Query: 1426 LHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDIN 1485
Q L R + +V SW+S E ++ ++ + NS+G + LQK++ F+
Sbjct: 472 YEQCLDFHLFYRDS-EQVDSWMSRQEAFLENED--LGNSLG--SAEALLQKHEDFEEAFT 526
Query: 1486 CKQ---LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLE 1542
++ +TVD ++ D E+ ++ + + A+ + + L+ E + LL+
Sbjct: 527 AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESL-LLQ 585
Query: 1543 GLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEV 1602
L E + LK W ++K+L D ++++ ++ Q E + + ++
Sbjct: 586 KLYEDSDD-------LKNWI-NKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQL 637
Query: 1603 EKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV---------- 1652
E I++ G +I+ S V + L E+ W L Q L
Sbjct: 638 ENIQKTGQEMIEG-GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNA 696
Query: 1653 --LDQWSSH---KVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 1707
L +W +V + L E + L + LL ++ A Q QVD L +L E
Sbjct: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFE-- 754
Query: 1708 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQR 1767
E P ++ + + + R+ L E +A + + LL L
Sbjct: 755 ----------------EIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798
Query: 1768 YKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVAT--WIQDCNDLLKGLGTVKDSLF 1825
+D + +E E +AT+ + D +A+ + +L+ + + + +
Sbjct: 799 CRD--------TEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQ 850
Query: 1826 FLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSL 1885
+ E G ++ ++ AA + S SL+Q++ +L ++Q L+A V ++ + L
Sbjct: 851 EITERGNKMVEE-GHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV-QFQQYLADL 908
Query: 1886 EALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP 1945
E WI E E I+ + ++ +D EE G +LK A LD LN G
Sbjct: 909 HEAETWIREKEPIV--DNTNYGAD--------EEAAGALLK-KHEAFLLD-LNSFG---- 952
Query: 1946 LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 2005
+K ++N + E + Q + + +F ++ +++ +
Sbjct: 953 ---DSMKALRNQANACQQQQAAPVEGVAGEQRVMALY-----------DFQARSPREVTM 998
Query: 2006 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII-----DGQRLLEQGQVDDRDEFNLK 2060
+ G+ LL + ++ E Q I+ ++ + D +L Q + ++ +
Sbjct: 999 K-KGDVLTLLSSIN-KDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQR 1056
Query: 2061 LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM-----AEKLRKWLVEVSYLPMSGLG 2115
+ NQ++ ++ RA++RR R QRY E A + +W+ E G
Sbjct: 1057 QEQIENQYRSLLDRAEERRR------RLLQRYNEFLLAYEAGDMLEWIQEKK---AENTG 1107
Query: 2116 SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQ 2175
+ + + FDE F++ + + + A L E L E A+I+
Sbjct: 1108 VELDDVWELQKKFDE--FQKDLNTNEPRLRDINKVADDLLF-------EGLLTPEGAQIR 1158
Query: 2176 EKWKS---ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH-EEL 2231
++ S + RL +++++L E + D+ E++ + LS + P +
Sbjct: 1159 QELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSV 1218
Query: 2232 HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQ 2291
A Q R + E + D +T L + LS + +++E L WE+L +
Sbjct: 1219 QALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME-LNEAWEDLQGR 1277
Query: 2292 LSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEM--IEKLKKDYQEE 2349
R++ + E ++ +F K ++L W++ + VS L E++ IE L + +QE
Sbjct: 1278 TKDRKESLNE-AQKFYLFLSKARDLQNWISSIGGMVSSQE--LAEDLTGIEILLERHQEH 1334
Query: 2350 IAIAQENKIQLQQMGERLAKA--SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET 2407
A + Q + + A+ S + EIE KL V L R KK+ +
Sbjct: 1335 RADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKR-KKILDQ 1393
Query: 2408 LVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGV 2467
+ +Q N + +W+ E+ L D + + ++ + ++ +L + I +
Sbjct: 1394 CLELQMFQGNCDQVESWMVARENSLRSD---DKSSLDSLEALMKKRDDLDKAITAQEGKI 1450
Query: 2468 ASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQK 2527
+ + E L+ D + A + +Q R LD RW+ + A ++ R K+ + L ++
Sbjct: 1451 TDLEHFAESLIAD-EHYAKEEIATRLQ---RVLD-RWKALKAQLIDERTKLGDYANL-KQ 1504
Query: 2528 FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQY 2587
F D E+W+ TA S Y A +K+ Q HE + E ++
Sbjct: 1505 FYRDLEELEEWISEMLPTACDES-----YKDATNIQRKYLKHQTFAHEVDGRSEQVHGVI 1559
Query: 2588 RRLARENRTDSAC-----SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARD 2642
L SAC ++K+ + + + WD+L +R ++L +++ F T+
Sbjct: 1560 -NLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNE-ASRQQRFNTSIR 1617
Query: 2643 SILVWLTEMDLQLTNIEHFSE-CDVQAKIKQLKAFQQEISLNHNKI-------EQIIAQG 2694
WL+E + L + + +K+ + ++E+ + + E +++ G
Sbjct: 1618 DFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSG 1677
Query: 2695 ----EQLIEKSEPLD---------AAIIEEELDE---LRRYCQEVFGRVERYHKKLIRLP 2738
+Q+++K + ++ AA E+L E L ++ Q++ +KLIR+
Sbjct: 1678 TFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVS 1737
Query: 2739 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS--GR 2796
D DL + L+ H R L++ +P+ L +A+ L+ + +
Sbjct: 1738 SQDYGRDLQGVQNLLKK---------HKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQE 1788
Query: 2797 DTPASVDSIPLEWDHDYDLSRDLESAMSRALP-------SEDEEGQDDKDFYLRGAVGLS 2849
+ + W+ +L++ + +L +E+EE ++ L G
Sbjct: 1789 EIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNAL-AVRGDC 1847
Query: 2850 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 2909
GD A + +AL++ F + +T +++ G ++ K+L E S +
Sbjct: 1848 GDTLAATQSLLMKHEALEND-FAVHETR--VQNVCAQGEDI------LNKVLQEESQN-- 1896
Query: 2910 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 2969
K + K++ E P A I W+L ++ +Q+F
Sbjct: 1897 --KEISSKIEALNEKTPSL----------AKAIAAWKL-----------QLEDDYAFQEF 1933
Query: 2970 NSDLNSIWAWLGDTEEELE---------QLQRLELSTDIQTIELQIKKLKELQKAVDHRK 3020
N + + AW+ D E L+ L D LQ + + L + D +
Sbjct: 1934 NWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKD 1993
Query: 3021 AIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG-- 3078
+I A +S+ +++R + + RW+++ R L + + Q
Sbjct: 1994 KLI-----------SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
Query: 3079 --FHEMSH---GLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 3133
F E +H L E ++ +E V S + LQ H+ + L +Q
Sbjct: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLA---SLARAQADF 2099
Query: 3134 ASLQDMSCQLLVNAEG----------TDCLEA--KEKVHVIGNRLKLLLKEVSRHIKELE 3181
L ++ Q + A G + LE K +I R + L KE +R +K E
Sbjct: 2100 KCLLELDQQ--IKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFE 2157
Query: 3182 KLLDVSSSQQDLSSW 3196
+ + W
Sbjct: 2158 MCQEFEQNASTFLQW 2172
Score = 134 bits (337), Expect = 2e-30
Identities = 446/2355 (18%), Positives = 873/2355 (37%), Gaps = 348/2355 (14%)
Query: 558 EADPAEQLALQSTLTVL--AERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCE 615
E P E + S VL AE + R + + Q +E++ ++ ++ LQ ++ +
Sbjct: 2 EQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRD 61
Query: 616 ADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL 675
AD+L W++ K + T S ++P +++ + Q++ E++ K +SEL E
Sbjct: 62 ADDLGKWIME-KVNILTDKS-YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERF 119
Query: 676 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPG 735
G + +E + +LR L LLEL D+ L Q +E
Sbjct: 120 TMGHS-AHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQE---------CAD 169
Query: 736 VQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 795
+ EW+ T ++ E+ + E + VA G + + A E + +
Sbjct: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQ-VELVAKEGRVVEVNQYANECAEE- 227
Query: 796 GEKPDV-LSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLE------------ 842
PD+ L Q S ++++ WE L +QK L N
Sbjct: 228 -NHPDLPLIQ---------SKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAI 277
Query: 843 ---QEQEQVLYSRP--NRLLSGVPLYKGDVPTQDKSAVTS-------------------- 877
+E+E VL S L++ L+ + AV S
Sbjct: 278 QWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSD 337
Query: 878 ------LLDGLNQAFEEVS--SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 929
+ + L ++E + + S K Q+ + + S W+++
Sbjct: 338 APQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNE------KTA 391
Query: 930 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQA-------FPENGDNRDVIEDTL 982
A+ +E T + E+L ++ E+D + F A N + D + + +
Sbjct: 392 AINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKM 451
Query: 983 GCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQP 1042
L + L + ++R Q ++ L L +++ +V ++ + L N
Sbjct: 452 EILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSA 511
Query: 1043 VAEQIEAIQQAEDGLKEFDA---GIIELKRRGDKLQVEQPSMQELSK-----LQDMYDEL 1094
A +Q+ ED + F A II + + KL + E K L D L
Sbjct: 512 EA----LLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDAL 567
Query: 1095 MMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKH 1154
+RR L ++L L+ YE + DL + + ++K+A D+ ++IQ L +
Sbjct: 568 REKAATRRRLLKESLLLQKLYEDS-DDLKNWINK-KKKLADDE-----DYKDIQNLKSRV 620
Query: 1155 KEYFQGLESHMILTETLFRKIIS----------FAVQKETQFHTELMAQASAVLKRAHKR 1204
++ Q E + + +T I +A T +E+ + +L+ ++
Sbjct: 621 QKQ-QVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQK 679
Query: 1205 GVELEYILETWSHLDEDQQELSRQLEVVESSIPS----VGLVEENEDRLIDRITLYQHLK 1260
G +L + + + ++L R LE VE + S GL E + +R+ + L+
Sbjct: 680 GTQL-HEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAE-----VQNRLRKHGLLE 733
Query: 1261 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKEL-HRLETILK 1319
S++ Q ++ +L +DL + ++G + + L R E + +
Sbjct: 734 SAVAARQDQV-DIL------------TDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE 780
Query: 1320 HWTRYQSESADLIHWLQSAKDR--LEFWTQQ------SVTVPQELEMVRDHLNAFLEFSK 1371
+ + DL+H +D E W Q+ S + ++L + LN +
Sbjct: 781 PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE 840
Query: 1372 EVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLH-QLQ 1430
+ + + GN+++ + S + ++ L Q L +Q
Sbjct: 841 NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ 900
Query: 1431 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDIN----- 1485
+ + + E +WI E ++ DN +A L+K++ F +D+N
Sbjct: 901 FQQYLA--DLHEAETWIREKEPIV----DNTNYGADEEAAGALLKKHEAFLLDLNSFGDS 954
Query: 1486 ----------CKQLTVDFV-----NQSVLQISSQDVESKRS---DKTDFAEQLGAMNKSW 1527
C+Q V Q V+ + S R K D L ++NK W
Sbjct: 955 MKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDW 1014
Query: 1528 QIL-----QGLVT---------EKIQLLE--------GLLESWSEYENNVQCLKTWFETQ 1565
+ QG+V ++ +L + + + EN + L E +
Sbjct: 1015 WKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEER 1074
Query: 1566 EKRLKQQ-------HRIGD------QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 1612
+RL Q+ + GD + +N + D+ +L K ++ + + N
Sbjct: 1075 RRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTN---- 1130
Query: 1613 IQNKKEDVSSIVMSTL-------------RELGQTWANLDHMVGQLKILLKSVLDQWSSH 1659
+ + D++ + L +EL W +L + + + LL S
Sbjct: 1131 -EPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSA------- 1182
Query: 1660 KVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD--NLQNLQDDLEKQERSLQKFG-- 1715
+ + EA + + +L A D ++Q LQ E ER L G
Sbjct: 1183 ----HAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
Query: 1716 ----SITNQLLKECHPPVTETLTNTLKEVNMRWNNL---LEEIAEQLQSSKALLQLWQRY 1768
T + L E HP TE L E+N W +L ++ E L ++ +
Sbjct: 1239 VTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKA 1298
Query: 1769 KDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLH 1828
+D +S + EL + T +I + D ++D L
Sbjct: 1299 RDLQNWISSIGGMVS--SQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELI 1356
Query: 1829 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEAL 1888
+ G +++ +Q+ +L LE+A K++ L L+ + F + + +
Sbjct: 1357 DSGHHASPEIE----KKLQAVKLERDD----LEKAWEKRKKILDQ-CLELQMFQGNCDQV 1407
Query: 1889 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPL 1946
E+W+V E L+ D S L + ++ ++L + DL+ E +
Sbjct: 1408 ESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYA 1467
Query: 1947 NDKEIKRMQNLNRHWSLISSQTTERFSKLQSF--LLQHQTFLEKCETWMEFLVQTEQKLA 2004
++ R+Q + W + +Q + +KL + L Q LE+ E W+ ++ T +
Sbjct: 1468 KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDES 1527
Query: 2005 VEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE-FNLKLTL 2063
+ + N Q + H+ F E+ R + +H +I G L+E D +E +L
Sbjct: 1528 YKDATNIQ---RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQ 1584
Query: 2064 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 2123
L W ++ R + ++ RQ QR+ WL E L + L
Sbjct: 1585 LKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETL--LAMKDQARDLAS 1641
Query: 2124 ARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE------LAEIQEK 2177
A L + Q E+ L ++ + + LL S + ++ + +QE
Sbjct: 1642 AGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQEL 1701
Query: 2178 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL--RTFKKKLS--QSLPDHHEELHA 2233
+ +L+E F +D + E I + L ++ + + + L Q+L H+ L
Sbjct: 1702 AAAHHEKLKEAYALFQF-FQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEG 1760
Query: 2234 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
E + + V L LKD A + ++I + R+ WE+L
Sbjct: 1761 ELVAHEPAIQNV------LDMAEKLKD--KAAVGQEEIQL---RLAQFVEHWEKLKELAK 1809
Query: 2294 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIEEMIEKLKKDYQEEIA 2351
R ++ E L E+ F + +E W+ + + + GD L +K + E
Sbjct: 1810 ARGLKLEESL-EYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
Query: 2352 IAQENKIQ-LQQMGERLAK--ASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 2408
E ++Q + GE + ES+ EI K+ +N++ L IAA +L++
Sbjct: 1869 AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDD- 1927
Query: 2409 VAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGV 2467
A Q+ + + W+A E+ L + + + L +Q L ++ +
Sbjct: 1928 YAFQEFNWKADVVEAWIADKETSLKTN--GNGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
Query: 2468 ASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMS-------MERRLKIEE 2520
+ +L + L+ A + +I++ L +RW + S +E++L +++
Sbjct: 1986 PEITDLKDKLI-----SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQK 2040
Query: 2521 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFE----------AFQ 2570
L+ +F S +W + E + P ++ V+ E+++ + A
Sbjct: 2041 AEDLFVEFAHKASALNNWCEKMEENLSEP-----VHCVSLNEIRQLQKDHEDFLASLARA 2095
Query: 2571 RQVHECLTQLE-------LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI 2623
+ +CL +L+ + + Y L E + L ++ E Q LQK
Sbjct: 2096 QADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQ---ELQKEEA-- 2150
Query: 2624 LRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC-DVQAKIKQLKAFQQEISL 2682
R++K+F +EFE + L W+ E + E ++++++ K Q+EI
Sbjct: 2151 -RQVKNF-EMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQA 2208
Query: 2683 NHNKIEQIIAQGEQL 2697
++ +I+ G+ L
Sbjct: 2209 MKRQLTKIVDLGDNL 2223
Score = 121 bits (304), Expect = 1e-26
Identities = 247/1260 (19%), Positives = 512/1260 (40%), Gaps = 157/1260 (12%)
Query: 1327 ESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
E+ D++ W+Q K + EL+ V + F EF K+++ +
Sbjct: 1090 EAGDMLEWIQEKK---------AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKV 1140
Query: 1387 GNQLL--RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVM 1444
+ LL L + A +R EL+ S+W L ++L Q L S HA+
Sbjct: 1141 ADDLLFEGLLTPEGAQIRQELN---SRWGSL--------QRLADEQRQLLGSAHAVE--- 1186
Query: 1445 SWISLMENVIQKDEDNIKNSIGYK--------------AIHEYLQKYKGFKIDINCKQLT 1490
V ++ D+ K I K ++ ++++GF+ D+
Sbjct: 1187 --------VFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
Query: 1491 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSE 1550
V + ++ ++S ES D Q +N++W+ LQG ++ + L + +
Sbjct: 1239 VTILGETAERLS----ESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNE-AQKFYL 1293
Query: 1551 YENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGL 1610
+ + + L+ W + + Q D ++ L+ Q+ ++A+ + +E
Sbjct: 1294 FLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSA 1353
Query: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL 1670
LI + S + L+ + +L+ + K +L L + + D++ S++
Sbjct: 1354 ELI-DSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCL-ELQMFQGNCDQVESWM 1411
Query: 1671 MEARYSL-SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPV 1729
+ SL S + SLEA+ + D+L + QE + L+ + H
Sbjct: 1412 VARENSLRSDDKSSLDSLEALMKKRDDLDKA---ITAQEGKITDLEHFAESLIADEH-YA 1467
Query: 1730 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 1789
E + L+ V RW L ++ ++ L Q Y+D + + +E
Sbjct: 1468 KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDES 1527
Query: 1790 LKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLF----------FLHELGEQLKQ 1836
K ATN K + A + ++ + G+ + +SL + E EQLK+
Sbjct: 1528 YKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKE 1587
Query: 1837 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 1896
D HL LE+ K + +A + F S+ E W+ EAE
Sbjct: 1588 HWD----------------HL--LERTNDKGKKLNEAS--RQQRFNTSIRDFEFWLSEAE 1627
Query: 1897 EILQGQDPSHS-SDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKR 1953
+L +D + + + ++ + L+ +ML DL+ L E L D+ +K+
Sbjct: 1628 TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKK 1687
Query: 1954 MQNLNRHWSLISSQTTERFSKLQSFLLQHQTF--LEKCETWME--FLVQTEQKLAVEISG 2009
N+N+ + + KL+ Q F L+ E+W+E + + Q ++ G
Sbjct: 1688 KDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQG 1747
Query: 2010 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 2069
Q+LL++ H+ + E+ + + + +++ ++L ++ V ++E L+L W+
Sbjct: 1748 -VQNLLKK---HKRLEGELVAHEPAIQNVLDMAEKLKDKAAV-GQEEIQLRLAQFVEHWE 1802
Query: 2070 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 2129
++ + RG+ + ++ ++ + AE+ W+ E + L + G L ++L
Sbjct: 1803 -KLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVR--GDCGDTLAATQSLLM 1859
Query: 2130 EVQFKEKVFLRQQGSYILTVEAGKQLL--LSADSGAEAALQAELAEIQEKWKSASMRLEE 2187
+ + E F + G+ +L + + + +++ + EK S + +
Sbjct: 1860 KHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAA 1919
Query: 2188 QKKKL----AFLLKDW--EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKEL 2241
K +L AF +W + E IAD L+T L D L + L
Sbjct: 1920 WKLQLEDDYAFQEFNWKADVVEAWIADKETSLKT--NGNGADLGDFLTLLAKQD----TL 1973
Query: 2242 ENAVGSWTDD-LTQLSLLKDTLSAYISA--DDISILNERVELLQRQWEELCHQLSLRRQQ 2298
+ ++ S+ + L +++ LKD L ISA + + ER L ++WE+L ++ RQ+
Sbjct: 1974 DASLQSFQQERLPEITDLKDKL---ISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQK 2030
Query: 2299 IGERL-------NEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE--- 2348
+ E+ + + F+ K L W +ME +S+ + I +L+KD+++
Sbjct: 2031 LLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLA 2090
Query: 2349 EIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDR-WQHLLDLIAARVKKLK-- 2405
+A AQ + L ++ +++ S S + +V +R W+HL D+I R ++L+
Sbjct: 2091 SLARAQADFKCLLELDQQIKALGVPS--SPYTWLTVEVLERTWKHLSDIIEEREQELQKE 2148
Query: 2406 -----ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 2460
+ Q+ ++N S+ W+ + + + E Q + N+++ Q++I
Sbjct: 2149 EARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRK--QKEI 2206
Query: 2461 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 2520
+ + +++L + L DA I+ +T L ++W + + + + +E+
Sbjct: 2207 QAMKRQLTKIVDLGDNL--------EDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2258
Score = 107 bits (266), Expect = 3e-22
Identities = 440/2253 (19%), Positives = 874/2253 (38%), Gaps = 330/2253 (14%)
Query: 52 HLEEYNEMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTL---LEESKEIDSEL 107
HL+ + + + KWI EK +L + + + ++ +Y HQ+L ++ + SEL
Sbjct: 54 HLQVFKRDADDLGKWIMEKVNILTDKS--YEDPTNIQGKYQKHQSLEAEVQTKSRLMSEL 111
Query: 108 EAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKK 167
E E+ ++ E+ + EL + L ++ + L A K +++ E
Sbjct: 112 EKTREE-RFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALK-FQQYVQECAD 169
Query: 168 LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVV 227
+ + +A TS E+G + ++ H++ ++E + + + V++ Q A E+
Sbjct: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENH 229
Query: 228 ASLPLCHAALRLQEEA-SRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIE 286
LPL + A RL+ A+Q+ + A +++++++ Q I+ E
Sbjct: 230 PDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAA-NLQRFKRDVTEAIQWIK------E 282
Query: 287 DKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVE 346
+PV TS ++ + E L KG + +A ++ K K L KA+ T L ++
Sbjct: 283 KEPVLTS--EDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAP 339
Query: 347 GLAEGTEDL--DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 404
+ E EDL E + + + H S E SG N + ++ A
Sbjct: 340 QIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSG--WMNEKTAAINADE 397
Query: 405 SPSPVANTDASVNQ------DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT 458
P+ VA + +++ +I Y +T ++ + AS E E
Sbjct: 398 LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVRE-------- 449
Query: 459 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ--SISTKMEAIELKLSESPEP 516
K+ L +W L + E+ R + L+ Y+DS Q S ++ EA L+ +
Sbjct: 450 -KMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAF-LENEDLGNS 507
Query: 517 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 576
S E+ + +H+ +E Q+E A +L+ + D + +++ L
Sbjct: 508 LGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGD----DHYDSENIKAIRDGLLA 562
Query: 577 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 636
R +R KA+ +R+LL+E L LQ+ ++D+L +W+ K D
Sbjct: 563 RRDALREKAATRRRLLKESL-----------LLQKLYEDSDDLKNWINKKKKLAD----- 606
Query: 637 PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENL---------LLEGKAHTKDEAE 687
+ D QN+ ++++ V EL+V+ L ++EG + D
Sbjct: 607 -------DEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVT 659
Query: 688 QLAGKLRRLKGSLLELQRA----LHD--KQLNMQGTAQEKEE--SDVDLTATQSPGVQEW 739
++ L LLE + LH+ +QL + A++ + DV+ T S +
Sbjct: 660 TRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVT-SEDYGKG 718
Query: 740 LAQARTTWT-----QQRQSSLQQQKELEQELAEQKSLL-----RSVASRGEEILIQHSAA 789
LA+ + + ++ Q Q ++ +LA + + + +R E ++ + A
Sbjct: 719 LAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEAL 778
Query: 790 ETSGDAGEKP--DVLSQELG-----------MEGEKSSAEDQMRMKWESLHQEFSTKQKL 836
+ +K D+L +L E E S+ + + + + + +
Sbjct: 779 KEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVI 838
Query: 837 LQNVLEQEQE-QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG 895
L+N+ E Q + R N+++ +G +D V S + LNQ E + +++
Sbjct: 839 LENIASHEPRIQEITERGNKMVE-----EGHFAAED---VASRVKSLNQNMESLRARA-- 888
Query: 896 AKRQS-----IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQ-EILAKD 949
A+RQ+ + +Q L D + TW+ + E + EE L + E D
Sbjct: 889 ARRQNDLEANVQFQQYLAD-LHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLD 947
Query: 950 IKEMSEEMDKNKNLFS-----QAFPENG-------------DNRDVIEDTL--GCLLGRL 989
+ + M +N + QA P G R E T+ G +L L
Sbjct: 948 LNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
Query: 990 SLLDS-----------------VVNQRCH--------QMKERLQQILNFQNDLKVLFTSL 1024
S ++ V + H + +E I Q ++ + SL
Sbjct: 1008 SSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
Query: 1025 ADNKYIILQKLANVFEQ-----PVAEQIEAIQQ--AEDGLKEFDAGIIELKRRGDKLQVE 1077
D ++L + + + +E IQ+ AE+ E D + EL+++ D+ Q +
Sbjct: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELD-DVWELQKKFDEFQKD 1126
Query: 1078 ----QPSMQELSKLQD--MYDELMMIIGSR-RSGLNQ---NLTLKSQYERALQDLADLLE 1127
+P +++++K+ D +++ L+ G++ R LN +L + +R L A +E
Sbjct: 1127 LNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVE 1186
Query: 1128 TGQEKMAGDQKIIVSSKEEIQQLLDKHKEYF---------QGLESHMI-LTETLFRKIIS 1177
+ A D K + K + D + F +G E ++ L + + I+
Sbjct: 1187 VFHRE-ADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKV--TILG 1243
Query: 1178 FAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEV------ 1231
++ ++ H + A+ L+R + +EL E +D++E + +
Sbjct: 1244 ETAERLSESHPD----ATEDLQR---QKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLS 1296
Query: 1232 ----VESSIPSVGLVEENEDRLID----RITLYQHLKSSLN-EYQPKLYQVLDDGKRLLI 1282
+++ I S+G + +++ D I L +H + + E + +Q L+D LI
Sbjct: 1297 KARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELI 1356
Query: 1283 SISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR---YQSESADLIHWLQSAK 1339
S ++ + + + + K + + IL +Q + W+ + +
Sbjct: 1357 D-SGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARE 1415
Query: 1340 DRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTA 1399
+ L + S+ + L RD L+ K + AQ + + L+ +
Sbjct: 1416 NSLRSDDKSSLDSLEALMKKRDDLD------KAITAQEGKITDLEHFAESLIADEHYAKE 1469
Query: 1400 TLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI----Q 1455
+ + L R+ +W L + + KL K R + E+ WIS M
Sbjct: 1470 EIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD-LEELEEWISEMLPTACDESY 1528
Query: 1456 KDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTD 1515
KD NI+ +YL K++ F +++ + V V+ + + +E D +
Sbjct: 1529 KDATNIQR--------KYL-KHQTFAHEVDGRSEQV----HGVINLGNSLIECSACDGNE 1575
Query: 1516 FA--EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 1573
A EQL + + W L +K + L + +++ + W E L +
Sbjct: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETLLAMKD 1634
Query: 1574 RIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQ 1633
+ D AS N LK Q LE + A+E ++ + L+ + +V IV + +
Sbjct: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK-DNVNK 1693
Query: 1634 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 1693
+ N+ + LK + + D S++ E +S + L+ VQ
Sbjct: 1694 RFLNVQELAAAHHEKLKEAYALFQFFQ-DLDDEESWIEEKLIRVSS-QDYGRDLQGVQNL 1751
Query: 1694 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 1753
+ + L+ +L E ++Q + + LK+ E + L + W L+E+A+
Sbjct: 1752 LKKHKRLEGELVAHEPAIQNVLDMAEK-LKDKAAVGQEEIQLRLAQFVEHWEK-LKELAK 1809
Query: 1754 ----QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQD 1809
+L+ S LQ Q +++E NE A D D AT
Sbjct: 1810 ARGLKLEESLEYLQFMQ-----------NAEEEEAWINEKNALAVRGDCGDTLAATQ--- 1855
Query: 1810 CNDLLKGLGTVKDSLFFLHEL--------GEQLKQQV--DASAASAIQSDQLSLSQHLCA 1859
+ L+K D F +HE GE + +V + S I S +L++ +
Sbjct: 1856 -SLLMKHEALEND--FAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPS 1912
Query: 1860 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQ-GQDPSHSSDLSTIQERME 1918
L +A+ + L+ ++ F + +EAWI + E L+ + + D T+ + +
Sbjct: 1913 LAKAIAAWKLQLEDDYA-FQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQD 1971
Query: 1919 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLN-----RHWSLIS--SQTTER 1971
L + F +RL E+ L DK I N + R+ +L+ Q E
Sbjct: 1972 TLDASLQSFQQ-----ERLPEI---TDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEA 2023
Query: 1972 FSKLQSFLLQHQTFLEKCE-TWMEFLVQTE------QKLAVEISG-----NYQHLLEQQR 2019
+ + LL+ Q L+K E ++EF + +K+ +S + + + Q+
Sbjct: 2024 SAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQK 2083
Query: 2020 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
HE F A + +R Q +++ + ++ V L + +L W+ + ++R
Sbjct: 2084 DHEDFLASL-ARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEERE 2142
Query: 2080 GIIDSQ-------IRQWQRYREMAEKLRKWLVE 2105
+ + Q + + A +W++E
Sbjct: 2143 QELQKEEARQVKNFEMCQEFEQNASTFLQWILE 2175
Score = 95.1 bits (235), Expect = 1e-18
Identities = 322/1712 (18%), Positives = 637/1712 (37%), Gaps = 254/1712 (14%)
Query: 1577 DQASVQNALKDCQDLEDLIKAKEK---EVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQ 1633
D ++Q + Q LE ++ K + E+EK + + + E+ + + EL
Sbjct: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI----EELRH 138
Query: 1634 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 1693
W +LL+ L++ A K Y+ E L G EA+
Sbjct: 139 LW----------DLLLELTLEKGDQLLRAL-KFQQYVQECADILEWI----GDKEAIATS 183
Query: 1694 VD-------------NLQNLQDDLEKQERSLQKFGSITNQLLKECHP--PVTETLTNTLK 1738
V+ ++ Q +L +E + + N+ +E HP P+ ++ N
Sbjct: 184 VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQN--- 240
Query: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 1798
EVN W L +A Q Q + + QR+K + ++++E T++D
Sbjct: 241 EVNAAWERL-RGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEP-------VLTSEDY 292
Query: 1799 ADDEVAT--WIQDCNDLLKGLGTVKDSLFFLHELGEQL--KQQVDASAASAIQSDQLSLS 1854
D VA+ L + L + D + L E+L DA ++ D +S
Sbjct: 293 GKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSW 352
Query: 1855 QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQD-PSHSSDLSTI 1913
+H+ AL + + LQA Y F+ + L W+ E + + P+ + +
Sbjct: 353 EHIRALATS---RYEKLQATYW-YHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVL 408
Query: 1914 QERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKRMQNLNRHWSLISSQTTER 1971
+R ++ K ++ + D + + +D+ ++M+ L+ +W+ + ER
Sbjct: 409 LDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDER 468
Query: 1972 FSKLQSFLLQHQTFL--EKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ-RAHELFQAEM 2028
+ + L H + E+ ++WM + E L E GN E + HE F+
Sbjct: 469 HRQYEQCLDFHLFYRDSEQVDSWMS---RQEAFLENEDLGNSLGSAEALLQKHEDFEEAF 525
Query: 2029 FSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQ 2088
++++ + ++ +L+ D + ++ LL+ + + +A RR ++ +
Sbjct: 526 TAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR-DALREKAATRRRLLKESLLL 584
Query: 2089 WQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG---SY 2145
+ Y + ++ L+ W+ + L + + L VQ K++VF ++ +
Sbjct: 585 QKLYED-SDDLKNWINKKKKLADDE------DYKDIQNLKSRVQ-KQQVFEKELAVNKTQ 636
Query: 2146 ILTVEAGKQLLLSADSGAEAALQAELAEIQEKW-------KSASMRLEEQKKKLAFLLKD 2198
+ ++ Q ++ A + L+E+ W K +L E ++L F
Sbjct: 637 LENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF---- 692
Query: 2199 WEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE---LENAVGSWTDDLTQL 2255
E D L + +++ D+ + L Q R ++ LE+AV + D Q+
Sbjct: 693 ----ENNAEDLQRWLEDVEWQVTSE--DYGKGLAEVQNRLRKHGLLESAVAARQD---QV 743
Query: 2256 SLLKDTLSAY---ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 2312
+L D L+AY I D + R E L ++E L L+ R++++ + L+ + +
Sbjct: 744 DILTD-LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
Query: 2313 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 2372
E W+ + E + L KD + +++ L+ + ASH
Sbjct: 803 EDEEA-WIQETEPSATST----------YLGKDLIASKKLLNRHRVILENI------ASH 845
Query: 2373 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 2432
E + EI + K+ + + +A+RVK L++NM SLR A +++L
Sbjct: 846 EPRIQEITERGNKMVEEGHFAAEDVASRVK----------SLNQNMESLRARAARRQNDL 895
Query: 2433 AKPIVYDS--CNSEEIQRKLNEQQEL--QRDIEKHSTGVASVLNLCEVLLHDCD------ 2482
+ + + E + + E++ + + ++L E L D +
Sbjct: 896 EANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSM 955
Query: 2483 -ACATDAECDSIQQA--TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 2539
A A QQA + R + + R E T + S +DW
Sbjct: 956 KALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWW 1015
Query: 2540 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ-LELINKQYRRLARENRTDS 2598
K + + +A +E +R+ +TQ E I QYR L
Sbjct: 1016 KVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLL------- 1068
Query: 2599 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 2658
D ++R +L+R F+ E +L W+ E + T +
Sbjct: 1069 ---------------DRAEERRRRLLQRYNEFLLAYE-----AGDMLEWIQEKKAENTGV 1108
Query: 2659 EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 2718
E ++Q K + FQ++++ N ++ I + L L ++ E ++R+
Sbjct: 1109 ELDDVWELQKKFDE---FQKDLNTNEPRLRDINKVADDL------LFEGLLTPEGAQIRQ 1159
Query: 2719 YCQEVFGRVERYHKKLIRLPLPDDEHDL--SDRELELEDSAALSDLHWHDRSADSLLSPQ 2776
+G ++R L D++ L S +E+ A ++ +L +
Sbjct: 1160 ELNSRWGSLQR---------LADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAAD 1210
Query: 2777 PSSNLSLSLAQPLRSERSGRDTPASVDSIP--------LEWDHDYDLSRDLE-SAMSRAL 2827
P S+L A R E RD D + L H D + DL+ M
Sbjct: 1211 PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHP-DATEDLQRQKMELNE 1269
Query: 2828 PSEDEEGQ---------DDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQT-- 2876
ED +G+ + + FYL L++ I +G + T
Sbjct: 1270 AWEDLQGRTKDRKESLNEAQKFYL-----FLSKARDLQNWISSIGGMVSSQELAEDLTGI 1324
Query: 2877 ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 2936
E ++ +++ + L + IDS H E E V L +
Sbjct: 1325 EILLERHQEHRADMEAEAPTFQALEDFSAELIDS----GHHASPEIEKKLQAVKLERDDL 1380
Query: 2937 QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 2996
+ A WE K ++ + Q F + + + +W+ E L R +
Sbjct: 1381 EKA-----WE--------KRKKILDQCLELQMFQGNCDQVESWMVARENSL----RSDDK 1423
Query: 2997 TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD 3056
+ + ++E +KK +L KA+ ++ I + + + ++ RL ++ RW
Sbjct: 1424 SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWK 1483
Query: 3057 RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPI---DSNLDAEILQ 3113
+ + L + R L D Q + + LE ++ +E++P +S DA +Q
Sbjct: 1484 ALKAQLIDERTKLGDYANLKQFYRD--------LEELEEWISEMLPTACDESYKDATNIQ 1535
Query: 3114 DHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLLLKE 3172
+ + HE+ +V + ++ L+ + EA KE++ + LL+
Sbjct: 1536 RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLER 1595
Query: 3173 VS---RHIKELEKLLDVSSSQQDLSSWSSADE 3201
+ + + E + ++S +D W S E
Sbjct: 1596 TNDKGKKLNEASRQQRFNTSIRDFEFWLSEAE 1627
Score = 87.4 bits (215), Expect = 2e-16
Identities = 190/1051 (18%), Positives = 409/1051 (38%), Gaps = 129/1051 (12%)
Query: 2027 EMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQI 2086
E F ++ ++ S G ++LE + E + + ++Q R +R ++
Sbjct: 2 EQFPKETVVES---SGPKVLETAE-----EIQERRQEVLTRYQSFKERVAERGQKLEDSY 53
Query: 2087 RQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ----QARTLFDEVQFKEKVFLRQQ 2142
Q ++ A+ L KW++E + P +Q + ++L EVQ K ++
Sbjct: 54 HL-QVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSE-- 110
Query: 2143 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK----- 2197
+E ++ + A +A + E++ W E+ +L LK
Sbjct: 111 ------LEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYV 164
Query: 2198 -------DWEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQMRCKELENAVGSW 2248
+W ++ IA S+E +++ L + D EL A++ R E+
Sbjct: 165 QECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANEC 224
Query: 2249 TDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 2308
++ + D+ ++ + + WE L L+L+RQ+
Sbjct: 225 AEE---------------NHPDLPLIQSKQNEVNAAWERL-RGLALQRQKALSNAANLQR 268
Query: 2309 FSEKNKELCEWLTQMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGE 2365
F E +W+ + E ++ D++ E + K + +A+ + +L E
Sbjct: 269 FKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAE 328
Query: 2366 RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 2425
+L SH S A +I+ + W+H+ L +R +KL+ T + + L W+
Sbjct: 329 KLT-LSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT-YWYHRFSSDFDELSGWM 386
Query: 2426 AHIESEL-AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 2484
+ + A + D E + L+ Q+ + +I+ + S + L++
Sbjct: 387 NEKTAAINADELPTDVAGGEVL---LDRHQQHKHEIDSYDDRFQSADETGQDLVN----- 438
Query: 2485 ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 2544
A D +++ LD W + + ER + E+ + F D + + W+ E
Sbjct: 439 ANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLD-FHLFYRDSEQVDSWMSRQE- 496
Query: 2545 TAAFPSSSGVIYTVAKEE--LKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 2602
AF + + ++ E L+K E F+ ++ ++K +L ++ DS ++
Sbjct: 497 --AFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSE-NI 553
Query: 2603 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 2662
K + R D L+++ + R LK + ++ +E + D + W+ + + ++
Sbjct: 554 KAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS-DDLKNWINKKKKLADDEDYKD 612
Query: 2663 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 2722
++++++++ + F++E+++N ++E I G+++IE + + L E+ +E
Sbjct: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH-YASDNVTTRLSEVASLWEE 671
Query: 2723 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA-----LSDLHWHDRSADSLLSPQP 2777
+ ++ +L H+ ++++L+ E++A L D+ W S D
Sbjct: 672 LLEATKQKGTQL---------HE-ANQQLQFENNAEDLQRWLEDVEWQVTSED------- 714
Query: 2778 SSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD 2837
+ L ++ ++S D+ DL A E+ D
Sbjct: 715 -------YGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDL------AAYFEEIGHPDS 761
Query: 2838 KDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQI--QQTENIIRSKTPTGPELDTSYK 2895
KD R + + E + K LD Q+ + TE+ T P ++Y
Sbjct: 762 KDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYL 821
Query: 2896 G-----YMKLLGECSSSIDSVKRLEHKLKEEEES-----LPGFVNLHSTETQTAGVIDRW 2945
G KLL ++++ E +++E E G ++ +
Sbjct: 822 GKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNM 881
Query: 2946 ELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 3005
E L+A+A ++ ++ N+Q +QQ+ +DL+ W+ + E ++ D +
Sbjct: 882 ESLRARAARRQNDLEANVQ-FQQYLADLHEAETWIREKEPIVD---NTNYGADEEAAGAL 937
Query: 3006 IKK----LKELQKAVDHRKAIILSINLCSPE 3032
+KK L +L D KA+ N C +
Sbjct: 938 LKKHEAFLLDLNSFGDSMKALRNQANACQQQ 968
Score = 53.5 bits (127), Expect = 3e-06
Identities = 50/211 (23%), Positives = 94/211 (44%), Gaps = 15/211 (7%)
Query: 2867 DDSRFQIQQTENIIRSKTPTGP-ELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 2925
DD I + NI+ K+ P + Y+ + L E + + LE K +EE
Sbjct: 63 DDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELE-KTREER--- 118
Query: 2926 PGFVNLHSTETQTAGVIDR----WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 2981
F HS +T I+ W+LL L K ++ + L K+QQ+ + I W+G
Sbjct: 119 --FTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRAL-KFQQYVQECADILEWIG 175
Query: 2982 DTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 3041
D E +EL D + E+ KK ++ Q + ++ ++ +N + E + + +
Sbjct: 176 DKEAIATS---VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDL 232
Query: 3042 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDA 3072
+Q + +++N W+R+ L + + L +A
Sbjct: 233 PLIQSKQNEVNAAWERLRGLALQRQKALSNA 263
Score = 40.0 bits (92), Expect = 0.039
Identities = 65/336 (19%), Positives = 143/336 (42%), Gaps = 28/336 (8%)
Query: 33 QQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTI---AWNSASQLREQ 89
+ +R+ +L + + L++ E + + WI K K LA N S++++Q
Sbjct: 564 RDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQ 623
Query: 90 YILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQ 149
+ + L ++++ + E ++ Y ++ ++ +++E+ EEL + K +
Sbjct: 624 QVFEKELAVNKTQLENIQKTGQEMIE--GGHYASDNVTTRLSEVASLWEELLEATKQKGT 681
Query: 150 NLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPK 209
L +A + ++ FE + LQ LE + +TS + G+ + Q R+H L E
Sbjct: 682 QLHEANQQLQ-FENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLE------- 733
Query: 210 VQAVQLCQSALRIPEDVVASL-PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYE 268
AV Q + I D+ A + H ++ Q + + + ++ + ++
Sbjct: 734 -SAVAARQDQVDILTDLAAYFEEIGHPD---SKDIRARQESLVCRFEALKEPLATRKKKL 789
Query: 269 QEMKHLQQLIEGAHRE----IEDKPVATSNI--QELQAQ---ISRHEELAQKIKGYQEQI 319
++ HLQ + E E +P ATS ++L A ++RH + + I ++ +I
Sbjct: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
Query: 320 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDL 355
+ + + ++ H + V+ L + E L
Sbjct: 850 QEITERGNKM-VEEGHFAAEDVASRVKSLNQNMESL 884
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 145 bits (365), Expect = 8e-34
Identities = 489/2680 (18%), Positives = 1038/2680 (38%), Gaps = 361/2680 (13%)
Query: 476 SEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMD 532
+E T+ E YQ +L+ + T + + E E + E Q A H+A M
Sbjct: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMM 357
Query: 533 EILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLL 592
E+ Q + + + +L+++ +D E+ +Q +T+L R +R+++ +
Sbjct: 358 ELTAHQSSVGSVLQA-GNQLITQGTLSDE-EEFEIQEQMTLLNARWEALRVESMDR---- 411
Query: 593 EEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 652
+ +L+D L E +++Q Q L +WL T+ + + P + D ++
Sbjct: 412 QSRLHDVLMELQKKQLQQ--------LSAWLTLTEERIQKMETCPLDD--------DVKS 455
Query: 653 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQL 712
+ +E+ S+L E + + H ++ +G E A+ + QL
Sbjct: 456 LQKLLEEHKSLQSDLEA--EQVKVNSLTHMVVIVDENSG----------ESATAILEDQL 503
Query: 713 NMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLL 772
G + W A R WT++R + LQ+ L QEL E++ LL
Sbjct: 504 QKLG--------------------ERWTAVCR--WTEERWNRLQEINILWQELLEEQCLL 541
Query: 773 RSVASRGEEILIQHSAAETSGDAGEKP--------DVLSQELGMEGEKSSAEDQMRMKWE 824
++ + EE L + +TS +K +L +++ M+ + ++
Sbjct: 542 KAWLTEKEEAL---NKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVG 598
Query: 825 SLHQEFSTKQKLLQNVLEQEQE-----QVLYSRPNRLLSGVP-LYKGDVPTQDKSAVTSL 878
L +K+ + E Q Q L N++ V L +P +D +
Sbjct: 599 QLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRV 658
Query: 879 LDGLNQAFEEVSSQS----GGAKRQSIHLE---QKLYDGVSATS-TWLDDVEERLFVATA 930
+ QA + S Q K++ IH++ +K +D +SA W+ ++ + + T
Sbjct: 659 RE---QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI--LKWKTAIQTT 713
Query: 931 LLPE-----ETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL 985
+ E +T + L K+ +E D+ N Q E + + + +
Sbjct: 714 EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADE-LNQTGQILVEQMGKEGLPTEEIKNV 772
Query: 986 LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAE 1045
L ++S V+Q ++ ++Q Q D+ F L + + +I K V ++E
Sbjct: 773 LEKVSSEWKNVSQHLEDLERKIQ----LQEDINAYFKQLDELEKVIKTKEEWVKHTSISE 828
Query: 1046 QI-EAIQQAEDGLKEFDAGI------IELKRRGDKLQVEQPSMQEL-----SKLQDMYDE 1093
+++ +D + + IE+ R + QPS + Y
Sbjct: 829 SSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQA 888
Query: 1094 LMMIIGSRRSGLNQNLTLKSQ----YERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQ 1149
+ + R+ L L K Q Y L+ L D+L + K ++ + ++++
Sbjct: 889 VQEAVEDRQQHLENEL--KGQPGHAYLETLKTLKDVLNDSENKAQVSLNVL-NDLAKVEK 945
Query: 1150 LLDKHKEYFQGLES-----HMILTET-LFRKIISFAVQK-ETQFHTELMAQASAVLKRAH 1202
L + K + LE+ H + ET K + V+K Q ++ + + +
Sbjct: 946 ALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS 1005
Query: 1203 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENE---DRLIDRITLY--- 1256
K LE I T + D + + ++ V+ + + ++ R +D+ + +
Sbjct: 1006 KDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNE 1065
Query: 1257 -QHLKSSLN---EYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELH 1312
+ ++SSL E + L G + + D ++QL +L + + +++S+
Sbjct: 1066 IETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQE 1125
Query: 1313 RLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSK 1371
+ + K + A++ W+ A++ E+ + P+ELE + + +K
Sbjct: 1126 KAANLKK-------DLAEMQEWMTQAEE--EYLERDFEYKSPEELESAVEEMKR----AK 1172
Query: 1372 EVDAQSSLKSSVLSTGNQLLRLKKVDTAT-LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 1430
E Q ++ +L +LL K L SEL+ + + L I L ++
Sbjct: 1173 EDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVW 1232
Query: 1431 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID--INCKQ 1488
+ H + +W++ +E ++ E + + E L+ D ++
Sbjct: 1233 SCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRE 1292
Query: 1489 LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESW 1548
L ++ +L D+ S E+L A N ++ L L K LE L+
Sbjct: 1293 LGQTLIDGGILD----DIIS---------EKLEAFNSRYEDLSHLAESKQISLEKQLQVL 1339
Query: 1549 SEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 1608
E + +Q L+ +K+L + D+ ++ Q ++ I A E +E++ +N
Sbjct: 1340 RETDQMLQVLQESLGELDKQLTTY--LTDRIDAFQVPQEAQKIQAEISAHELTLEELRRN 1397
Query: 1609 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 1668
+ + ++S T R G +L+ L + S+ F K +
Sbjct: 1398 ------MRSQPLTSPESRTARG------------GSQMDVLQRKLREVSTKFQLFQKPAN 1439
Query: 1669 Y---LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 1725
+ +++ + L + L+ V D +Q D K ++L + ++K
Sbjct: 1440 FEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTG 1499
Query: 1726 HPPVTETLTNT-------LKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAST 1778
V + T+ L + + +N+L ++ E Q + QL ++ K K+ AS
Sbjct: 1500 RHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMK---KEAASL 1556
Query: 1779 VQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 1838
+ EL++ +T++ + D + T I ++LK L K L + E L+ +
Sbjct: 1557 SEWLSATETELVQKSTSEGLLGD-LDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615
Query: 1839 DASAASAIQSDQLSLSQHLCALEQALCKQQT-------SLQAGVLDYETFAKSLEALEAW 1891
+ S + L + LC L + +T +L E F ++ + W
Sbjct: 1616 EGS--------EPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTW 1667
Query: 1892 IVEAEEILQGQDPSHSSDLSTIQERM-EELKGQMLKFSSMAPD-LDRLNELGYRLPLNDK 1949
+ +AE +L + +S I +R+ EL L+ ++ L +N G + +
Sbjct: 1668 LYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGS----SSR 1723
Query: 1950 EI--KRMQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE 2006
E+ ++ LNR++ +S + + Q L Q E ET + F +KL +
Sbjct: 1724 ELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPF--SDLEKLEND 1781
Query: 2007 ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE-FNLKLTLLS 2065
I N +E+ +M + ++ G+ +L Q D++ E L+L LL
Sbjct: 1782 IE-NMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLH 1840
Query: 2066 NQWQGV--IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 2123
++ + I Q++ G + S IR + ++ K L+ + + +S + +P +
Sbjct: 1841 TRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELS----LNVP-EL 1895
Query: 2124 ARTLFDEVQFKE------KVFLRQQGSYILTVEAGKQLLLSADSGAEAA-LQAELAEIQE 2176
++++ F+E K L + G I + + ++ SG EA ++ L ++
Sbjct: 1896 NTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNA 1955
Query: 2177 KWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSL-PDHHEELHAEQ 2235
KW + ++K +++W + + D + + ++ L + P +L +
Sbjct: 1956 KWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKAR 2015
Query: 2236 MRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLR 2295
+ +ELE + S L+ D + +S D S L E++ L ++W+ + ++ R
Sbjct: 2016 IHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDR 2075
Query: 2296 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQE 2355
+ ++ + + + E+ WLT+ E + + + E +++L +D +E+ + E
Sbjct: 2076 QPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQEL-RDLTQEMEVHAE 2134
Query: 2356 -----NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK------- 2403
N+ +L+ + ++ K SE L VN W + + +K+
Sbjct: 2135 KLKWLNRTELEMLSDKSLSLPERDKISE---SLRTVNMTWNKICREVPTTLKECIQEPSS 2191
Query: 2404 LKETLVAVQ-----------------------------QLDKNMSSLRTWLAHIESELAK 2434
+ +T +A LDK ++ L WL I+ L
Sbjct: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKS 2251
Query: 2435 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 2494
IV + EEI + ++ + + D+E+ + V L + L + A ++D +I
Sbjct: 2252 NIVTVG-DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKN--KASSSDMR-TAIT 2307
Query: 2495 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER-TAAFPSSSG 2553
+ + +W R+ ++E+ + D +++D + +E + +
Sbjct: 2308 EKLERVKNQWDGTQHGVELRQQQLED-------MIIDSLQWDDHREETEELMRKYEARLY 2360
Query: 2554 VIYTVAKEELKKFEAFQRQVHECLTQ--------LELINKQYRRLARENRTDSACSLKQM 2605
++ ++ L K Q ++ L Q + + ++L E +D ++K+
Sbjct: 2361 ILQQARRDPLTK----QISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKET 2416
Query: 2606 VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--E 2663
W NL++ + L+ + ++ L W+ E + + + S E
Sbjct: 2417 TEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRE 2476
Query: 2664 CDVQAKI--KQLKAFQQEISLN---HNKIEQIIAQGEQLIEKS--EPLDAAIIEEELDEL 2716
+Q I ++LK Q+I HN I + I Q + K+ +A +++ LD++
Sbjct: 2477 NALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM 2536
Query: 2717 RRYCQEVFGR-----------VERYHKKLIRLPLPDDEHDLSDRELELE-----DSAALS 2760
+ ++ + E++++ L+ L ++ D EL+ + D AL
Sbjct: 2537 NQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQ 2596
Query: 2761 DLHWHDRSADSLLSPQPSSNLS------LSLA-QPLRS-ERSGRDTPASVDSIPLEWDHD 2812
+ H ++ L + S L+ + LA QP+ + E R+ + + P
Sbjct: 2597 LQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTP------ 2650
Query: 2813 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQ 2872
+ +++A+ + E ++ + ++R L A+DD
Sbjct: 2651 ----EERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDAD 2706
Query: 2873 IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLH 2932
+++ E++ P G L S + +++ + I + + K + S ++LH
Sbjct: 2707 MKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPI-NFKVKTVNDLSSQLSPLDLH 2765
Query: 2933 STETQTAGVID---RWELLQAQALSKELRMKQNLQKWQQF 2969
+ + + D RW+LLQ +S + R+KQ + + F
Sbjct: 2766 PSLKMSRQLDDLNMRWKLLQ---VSVDDRLKQLQEAHRDF 2802
Score = 137 bits (345), Expect = 2e-31
Identities = 486/2569 (18%), Positives = 977/2569 (38%), Gaps = 456/2569 (17%)
Query: 38 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 97
++ +R S+L+ L++ + L+ + W+ L I L + Q LL
Sbjct: 407 ESMDRQSRLHDVLMELQK--KQLQQLSAWL----TLTEERIQKMETCPLDDDVKSLQKLL 460
Query: 98 EESKEIDSELEAMTEKLQYLTSVY----------CTEKMSQQVAELGRETEELRQMIKIR 147
EE K + S+LEA K+ LT + T + Q+ +LG + + + R
Sbjct: 461 EEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEER 520
Query: 148 LQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLS---HRQHLLSEME 204
LQ+ ++ E L+A L + + L + +++LS R +L E
Sbjct: 521 WNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDM 580
Query: 205 SLKPKV--QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVV 262
+K + Q ++ Q ++ ++ AS + + L + L N + AV
Sbjct: 581 EMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVA 640
Query: 263 QYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQEL-------QAQISRHEELAQKIKGY 315
+ + K L + + + ++ + + QEL + QI E +K
Sbjct: 641 KLGMSQIPQKDLLETV-----RVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAI 695
Query: 316 QEQIAS--LNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMT 373
++ + L K + T + K + +E++ + E E +P
Sbjct: 696 SAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIP-----------R 744
Query: 374 AGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTD---------ASVNQDI-AYY 423
A + + E+ G+EG +E + S N + +DI AY+
Sbjct: 745 ADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYF 804
Query: 424 QALS--AERLQTDAAKI-HPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 480
+ L + ++T + H S S S P L+ S +L +L + E R
Sbjct: 805 KQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKI-----EMAR 859
Query: 481 TLYEALERQQKYQDSLQ----SISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILM 536
AL Q D +Q S + +A++ + E + E + A ++ +
Sbjct: 860 ASCSALMSQPSAPDFVQRGFDSFLGRYQAVQ-EAVEDRQQHLENELKGQPGHAYLETLKT 918
Query: 537 LQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKL 596
L+D +N+ ++ L + A + L + TL + E K + + + LE+ +
Sbjct: 919 LKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNV 978
Query: 597 NDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVE 656
+ +E + Y+ E D++ K + L +E + + + + + ++E
Sbjct: 979 HPDVE--------KLYKQEFDDVQGKWNKLKVLVSKDLHLLEE-IALTLRAFEADSTVIE 1029
Query: 657 IEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQG 716
V ++ L++ +A D+A L +L + + E++ ++
Sbjct: 1030 KWMDGV---------KDFLMKQQAAQGDDA-GLQRQLDQCSAFVNEIE--------TIES 1071
Query: 717 TAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE-LEQELAEQKSLLRSV 775
+ + +E + +L + G++ TW Q R Q Q E L +E+A QKS L
Sbjct: 1072 SLKNMKEIETNLRSGPVAGIK--------TWVQTRLGDYQTQLEKLSKEIATQKSRLSE- 1122
Query: 776 ASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKW-ESLHQEFSTKQ 834
Q AA D E QE + E+ E K E L +
Sbjct: 1123 --------SQEKAANLKKDLAE-----MQEWMTQAEEEYLERDFEYKSPEELESAVEEMK 1169
Query: 835 KLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSG 894
+ ++VL++E R L + L VP S L LN E
Sbjct: 1170 RAKEDVLQKE------VRVKILKDNIKLLAAKVP----SGGQELTSELNVVLENYQLLCN 1219
Query: 895 GAKRQSIHLEQ------KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAK 948
+ + LE+ +L + +TWL+ +EER+ +T +LPE+T+
Sbjct: 1220 RIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERM-KSTEVLPEKTDA---------- 1268
Query: 949 DIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQ 1008
+ E E ++ DNR I + LG L +LD +++++ R +
Sbjct: 1269 -VNEALESLE-------SVLRHPADNRTQIRE-LGQTLIDGGILDDIISEKLEAFNSRYE 1319
Query: 1009 QILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE-L 1067
+ + LA++K I L+K V + E + +Q ++ L E D + L
Sbjct: 1320 DL-----------SHLAESKQISLEKQLQV----LRETDQMLQVLQESLGELDKQLTTYL 1364
Query: 1068 KRRGDKLQVEQPSMQ---ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 1124
R D QV Q + + E+S + +EL RR+ +Q LT D
Sbjct: 1365 TDRIDAFQVPQEAQKIQAEISAHELTLEEL------RRNMRSQPLTSPESRTARGGSQMD 1418
Query: 1125 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGL--ESHMILTETLFRKIISFAVQK 1182
+L+ +++ ++ Q++LD K G+ E H++ + + +I
Sbjct: 1419 VLQRKLREVSTKFQLFQKPANFEQRMLD-CKRVLDGVKAELHVLDVKDVDPDVI------ 1471
Query: 1183 ETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLV 1242
Q H + + + K + +E+E +++T H+ + QQ
Sbjct: 1472 --QTHLD---KCMKLYKTLSEVKLEVETVIKTGRHIVQKQQ------------------- 1507
Query: 1243 EENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLS 1302
+N + +++T + L + L + +GK+ DLE + +QL
Sbjct: 1508 TDNPKGMDEQLTSLKVLYNDLGAQ-------VTEGKQ--------DLE-RASQLARKMKK 1551
Query: 1303 NTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDH 1362
+S+ L ET L + + DL + AK+ V ++LE +
Sbjct: 1552 EAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKN-----------VLKDLEKRKAD 1600
Query: 1363 LNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRI---DSQWTDLLTNI 1419
LN E SS L G++ + +++ L + SR+ W + L N
Sbjct: 1601 LNTITE--------SSAALQNLIEGSEPILEERL--CVLNAGWSRVRTWTEDWCNTLMN- 1649
Query: 1420 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 1479
HQ Q++ ++ + +W+ E ++ + E K + + K
Sbjct: 1650 -------HQNQLEIFDGN--VAHISTWLYQAEALLDEIEK--------KPTSKQEEIVKR 1692
Query: 1480 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAE-QLGAMNKSWQ-ILQGLVTEK 1537
+++ L V+ V L + + ++ S + E +L +N++++ + Q + + K
Sbjct: 1693 LVSELDDANLQVENVRDQALIL----MNARGSSSRELVEPKLAELNRNFEKVSQHIKSAK 1748
Query: 1538 IQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALK------DCQDL 1591
+ + + E QCL T ET E + + ++N LK + D
Sbjct: 1749 LLIAQ---------EPLYQCLVT-TETFETGVPFSDLEKLENDIENMLKFVEKHLESSDE 1798
Query: 1592 EDLIKAKEKEVEKIEQNGLALI-----QNKKEDV--SSIVMSTLRELGQTWANLDHMVGQ 1644
++ + + ++E++ Q G ++ NKKE + +++ T + +GQ
Sbjct: 1799 DEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQ 1858
Query: 1645 LKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDL 1704
L ++S L + + V +KI + + SL+ L T E Q D+L+N++D L
Sbjct: 1859 LASGIRSSLLP-TDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQL 1917
Query: 1705 EKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL 1764
+K + ++ E P + +TL ++N +W+ + +++ ++
Sbjct: 1918 DKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEE 1977
Query: 1765 WQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSL 1824
W+++ + + E+ + + D+ + +L G+ + + S
Sbjct: 1978 WRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQ-----QELEVGISSHQPSF 2032
Query: 1825 FFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKS 1884
L+ G+ + Q++ + S ++ L+Q A+ + +Q L+ +
Sbjct: 2033 AALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQ 2092
Query: 1885 LEALEAWIVEAEEILQGQDPSH-SSDLSTIQERMEELK--GQMLKFSSMAPDLDRLNELG 1941
L+ + W+ +AE +Q + + +L +++ +E++ + LK+ + +L+ L++
Sbjct: 2093 LDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRT-ELEMLSDKS 2151
Query: 1942 YRLPLNDKEIKRMQNLNRHWSLI---------------SSQTTERFS---KLQSFLL--- 1980
LP DK + ++ +N W+ I SS + R + +Q +L
Sbjct: 2152 LSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSS 2211
Query: 1981 -------QHQTF-------LEKCETWM-EFLVQTEQKLAVEI--SGNYQHLLEQQRAHEL 2023
H+T L+K T + ++LV +Q L I G+ + + + ++
Sbjct: 2212 ASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKI 2271
Query: 2024 FQAEMFSRQQILHSIIIDGQRLLEQGQVDD-RDEFNLKLTLLSNQWQGV-----IRRAQQ 2077
+A++ R L + Q L + D R KL + NQW G +R+ Q
Sbjct: 2272 TKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQL 2331
Query: 2078 RRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV 2137
IIDS QW +RE E+L + Y+ LQQAR Q +
Sbjct: 2332 EDMIIDS--LQWDDHREETEELMRKYEARLYI-----------LQQARRDPLTKQISDNQ 2378
Query: 2138 FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 2197
L Q+ L G A L ++ E++ S R K+ +L
Sbjct: 2379 ILLQE--------------LGPGDGIVMAFDNVLQKLLEEYGSDDTR--NVKETTEYLKT 2422
Query: 2198 DWEKCEKGIAD--------------SLEKLRTFKKKLSQS------LPD--HHEELHAEQ 2235
W ++ IAD S L F K + ++ L D H E +
Sbjct: 2423 SWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDS 2482
Query: 2236 MRCKELENAVGSWTDDLTQLSLL--------KDTLSAYISADDISILNERVELLQRQWEE 2287
+ +EL+ + ++ + + + + A ++++ ++L R++ + ++W +
Sbjct: 2483 ILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWND 2542
Query: 2288 LCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ----NGDI----LIEEMI 2339
L + + R + +W +EL +WL + ++ + GD+ L +
Sbjct: 2543 LKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHC 2602
Query: 2340 EKLKKDYQEE-------------------IAIAQENKIQLQ--------QMGERLAKASH 2372
+ L+++ +E+ I +E + LQ + +++AKA
Sbjct: 2603 KALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMR 2662
Query: 2373 ESKASEIEYK---LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
+ ++SE++ K L V WQ +D ++KL++ A+ LD +M
Sbjct: 2663 K-QSSEVKEKWESLNAVTSNWQKQVD---KALEKLRDLQGAMDDLDADM 2707
Score = 114 bits (285), Expect = 2e-24
Identities = 480/2732 (17%), Positives = 1041/2732 (38%), Gaps = 482/2732 (17%)
Query: 759 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP-DVLSQELGMEGEKS---S 814
++ ++E E+ ++S A E + AET E D+ S ++ +E + S
Sbjct: 271 RKYKKECEEEAINIQSTAPEEEH---ESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLS 327
Query: 815 AEDQMRMK------WESLHQEFSTKQKLLQNVL-EQEQEQVLYSRPNRLLSGVPLYKGDV 867
AED + + E + +F+T + + + Q + N+L++ +G +
Sbjct: 328 AEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLIT-----QGTL 382
Query: 868 PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS------IHLEQKLYDGVSATSTWLDDV 921
+++ + + LN +E + +S RQS + L++K +SA WL
Sbjct: 383 SDEEEFEIQEQMTLLNARWEALRVES--MDRQSRLHDVLMELQKKQLQQLSA---WLTLT 437
Query: 922 EERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPE----NGDNRDV 977
EER+ ++ ETC + D+K + + ++++K+L S E N V
Sbjct: 438 EERI--------QKMETCPLDD-----DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMV 484
Query: 978 I-------EDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYI 1030
+ E L +L L C +ER ++ ++ +L+ L + + +
Sbjct: 485 VIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL----QEINILWQELLEEQCL 540
Query: 1031 ILQKLANVFEQPVAEQIEAIQQAEDG----LKEFDAGIIELKRRGDKLQVEQPSMQELSK 1086
+ L E+ EA+ + + KE + L + +++++ ++ +LS+
Sbjct: 541 LKAWLT--------EKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSE 592
Query: 1087 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 1146
+ +L+ + + + + L +++ +Q L D + +A + K+
Sbjct: 593 IGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDL 652
Query: 1147 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 1206
++ + + + + + + ++ I ++ + +F + +LK K +
Sbjct: 653 LETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILK--WKTAI 710
Query: 1207 ELEYILETWSHLDEDQQELSRQLEVVESS----IPSVGLVEENEDRLIDRITLYQHLKSS 1262
+ I E +D E+ ++L+ +E IP + + L++++ K
Sbjct: 711 QTTEIKEYMKM--QDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMG-----KEG 763
Query: 1263 L--NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILK- 1319
L E + L +V + K +S DLE ++ QL E + N K+L LE ++K
Sbjct: 764 LPTEEIKNVLEKVSSEWKN--VSQHLEDLERKI-QLQE----DINAYFKQLDELEKVIKT 816
Query: 1320 --HWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQS 1377
W ++ S S L S KD + + + ++EM R +A + D
Sbjct: 817 KEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQ 876
Query: 1378 SLKSSVLSTGNQLLRLKKVDTATLRSELS-RIDSQWTDLLTNIPAV---QEKLHQLQMDK 1433
S L + + L +EL + + + L + V E Q+ ++
Sbjct: 877 RGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNV 936
Query: 1434 LPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDF 1493
L + + + ++ +++ + A+H+ ++ K + +++
Sbjct: 937 LNDLAKVEKALQEKKTLDEILENQKP---------ALHKLAEETKALEKNVH-------- 979
Query: 1494 VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYEN 1553
DVE + K +F + G NK L+ LV++ + LLE + + +E
Sbjct: 980 ----------PDVE--KLYKQEFDDVQGKWNK----LKVLVSKDLHLLEEIALTLRAFEA 1023
Query: 1554 NVQCLKTWFE-TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 1612
+ ++ W + ++ +KQQ GD A +Q L C + I+ E ++ +++ L
Sbjct: 1024 DSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNL 1083
Query: 1613 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 1672
+ + V + L + L + K L ++ ++ K ++ ++ +
Sbjct: 1084 RSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQ 1143
Query: 1673 ARYSLSRFRLLTGSLEAVQVQVDNLQNLQDD-LEKQERS--------------------- 1710
A S E ++ V+ ++ ++D L+K+ R
Sbjct: 1144 AEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQEL 1203
Query: 1711 -------LQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLE----------EIAE 1753
L+ + + N++ +CH TL+EV W LL + E
Sbjct: 1204 TSELNVVLENYQLLCNRIRGKCH---------TLEEVWSCWIELLHYLDLETTWLNTLEE 1254
Query: 1754 QLQSSKALLQLWQRYKDYSKQCASTVQQQED---RTNELLKAATNKDIADDEVATWIQDC 1810
+++S++ L + + + S ++ D + EL + + I DD ++ ++
Sbjct: 1255 RMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAF 1314
Query: 1811 NDLLKGLG--------TVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE- 1861
N + L +++ L L E +Q+ Q + S + L+ + A +
Sbjct: 1315 NSRYEDLSHLAESKQISLEKQLQVLRET-DQMLQVLQESLGELDKQLTTYLTDRIDAFQV 1373
Query: 1862 -QALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE--------EILQGQDPSHSSDLST 1912
Q K Q + A L E +++ + E+ ++LQ + S+
Sbjct: 1374 PQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQL 1433
Query: 1913 IQ------ERMEELKG---------QMLKFSSMAPD-----LDRLNELGYRLPLNDKEIK 1952
Q +RM + K +L + PD LD+ +L L E++
Sbjct: 1434 FQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVE 1493
Query: 1953 RMQNLNRHWSLISSQTTER--------------FSKLQSFLLQHQTFLEKCETWMEFLVQ 1998
+ RH ++ Q T+ ++ L + + + + LE+ + +
Sbjct: 1494 TVIKTGRH--IVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKK 1551
Query: 1999 TEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFN 2058
L+ +S L+++ + L ++ + +++ D LE+ + D +
Sbjct: 1552 EAASLSEWLSATETELVQKSTSEGLL-GDLDTEISWAKNVLKD----LEKRKAD-LNTIT 1605
Query: 2059 LKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE-VSYLPM--SGLG 2115
L N +G ++R ++++ W R R E L+ + L + +
Sbjct: 1606 ESSAALQNLIEGSEPILEERLCVLNAG---WSRVRTWTEDWCNTLMNHQNQLEIFDGNVA 1662
Query: 2116 SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE----L 2171
+ L QA L DE++ +K +Q+ E K+L+ D +A LQ E
Sbjct: 1663 HISTWLYQAEALLDEIE--KKPTSKQE-------EIVKRLVSELD---DANLQVENVRDQ 1710
Query: 2172 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE-E 2230
A I + +S R E + KLA L +++EK + I + KL ++ L Q L E
Sbjct: 1711 ALILMNARGSSSR-ELVEPKLAELNRNFEKVSQHIKSA--KLLIAQEPLYQCLVTTETFE 1767
Query: 2231 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNE---RVELLQRQWEE 2287
++LEN + + +LK S+D+ ++E ++E + ++ EE
Sbjct: 1768 TGVPFSDLEKLENDIEN---------MLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEE 1818
Query: 2288 LCHQ---------LSLRRQQIGERLNEWAVFSEKNKEL-------------CEWLTQMES 2325
+ HQ + L+ + R N+ + +++ ++L ++
Sbjct: 1819 MLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINK 1878
Query: 2326 KVSQNGDILIEEMIEKLKKDYQEEIAIAQEN----KIQLQQMGERLAKASHESK------ 2375
+ D+ + + +L E+ + +++ K QL ++GE++A HE +
Sbjct: 1879 ILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIA-VIHEKQPDVILE 1937
Query: 2376 -----ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 2430
A +I L ++N +W + + + R + +Q +++ L W+ E
Sbjct: 1938 ASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEE 1997
Query: 2431 ELAKPIVYDSC---NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 2487
++ D+C S ++++ QQEL+ I H A++ + ++ +
Sbjct: 1998 -----LLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKL----SQ 2048
Query: 2488 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 2547
A+ +++ L++RW I A +R+ +++ + K+ WL +E
Sbjct: 2049 ADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ 2108
Query: 2548 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL----- 2602
S+ T E L++ +++ +L+ +N R E +D + SL
Sbjct: 2109 KRST-----TELGENLQELRDLTQEMEVHAEKLKWLN----RTELEMLSDKSLSLPERDK 2159
Query: 2603 -KQMVHEGNQRWDNLQKRVTSILRRL-------------KHFIGQREEFETARDSILV-- 2646
+ + N W+ + + V + L+ H Q+ ++ I V
Sbjct: 2160 ISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQS 2219
Query: 2647 ---------------------WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLN 2683
WL +D L +NI + + + + ++K + ++
Sbjct: 2220 HRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQR 2279
Query: 2684 HNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD- 2741
H +++ + + L K+ D I E+L+ ++ VE ++L + +
Sbjct: 2280 HPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSL 2339
Query: 2742 --DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL---------------S 2784
D+H EL + A L L R L+ Q S N L +
Sbjct: 2340 QWDDHREETEELMRKYEARLYILQQARRDP---LTKQISDNQILLQELGPGDGIVMAFDN 2396
Query: 2785 LAQPLRSERSGRDT---PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 2841
+ Q L E DT + + + W + D ++A+ + +D ++F
Sbjct: 2397 VLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFL 2456
Query: 2842 ---------LRGAVGLSGDHSALESQI--RQLGKALDDSRFQIQQTENIIRSKTPTGPEL 2890
+ V S +AL+ I R+L + + D + +I +I +S +
Sbjct: 2457 KWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKS-------I 2509
Query: 2891 DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQA 2950
D + + +K LG + L+H+L + + RW L+A
Sbjct: 2510 DGNRQKMVKALGNS----EEATMLQHRLDDMNQ--------------------RWNDLKA 2545
Query: 2951 QALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK 3010
++ S ++ + +KW + L + WL +EEL+ +++ + D+ ++LQ K
Sbjct: 2546 KSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELK--KQMPIGGDVPALQLQYDHCK 2603
Query: 3011 ELQK-----------AVDHRKAIILSINLCSPEFTQAD-------------SKESRDLQD 3046
L++ AVD + + + +PE + + K ++ ++
Sbjct: 2604 ALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRK 2663
Query: 3047 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSN 3106
+ S++ +W+ + ++ W+ + AL + + L ++ + +N P+ +
Sbjct: 2664 QSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPV-GD 2722
Query: 3107 LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 3166
L + LQDH +++M + E+ +V ++ D+S Q L + L+ ++ + R
Sbjct: 2723 LLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQ-LSPLDLHPSLKMSRQLDDLNMRW 2781
Query: 3167 KLLLKEVSRHIKELEKL-LDVSSSQQDLSSWS 3197
KLL V +K+L++ D S Q S S
Sbjct: 2782 KLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTS 2813
Score = 67.4 bits (163), Expect = 2e-10
Identities = 198/1080 (18%), Positives = 416/1080 (38%), Gaps = 159/1080 (14%)
Query: 2274 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI 2333
+ E++ LL +WE L + R+ ++ + L E + ++ ++L WLT E ++ +
Sbjct: 390 IQEQMTLLNARWEALRVESMDRQSRLHDVLME--LQKKQLQQLSAWLTLTEERIQKMETC 447
Query: 2334 LIEEMIEKLKKDYQEEIAI-----AQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVN 2387
+++ ++ L+K +E ++ A++ K+ L M + + S ES + +E +L K+
Sbjct: 448 PLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLG 507
Query: 2388 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQ 2447
+RW + R +L+E + Q+L + L+ WL E L K + + +E+
Sbjct: 508 ERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELS 567
Query: 2448 RKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDS-IQQATRNLDRRWRN 2506
+ L+ D+E L+ + D +++ I + L +RW +
Sbjct: 568 VSVRRLAILKEDMEMKR----QTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDS 623
Query: 2507 ICAMSMERRLKIEETW------RLWQKFLDDYSRFEDWL---KSSERTAAFPSSSGVIYT 2557
+ + ++ + ++ QK L + R + KS + P
Sbjct: 624 LVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIH 683
Query: 2558 VAKEELKKFEAFQRQVHECL----TQLELIN-KQYRRLARENRTDSACSLKQMVHEGNQR 2612
V E KKF+A ++ + T ++ K+Y ++ ++ ++ LK + E +R
Sbjct: 684 VDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKM--QDTSEMKKKLKALEKEQRER 741
Query: 2613 W---DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC--DVQ 2667
D L + ++ ++ EE + + + + L ++E + D+
Sbjct: 742 IPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDIN 801
Query: 2668 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV 2727
A KQL +++E++I E+ ++ + +++ + L L+ CQ +
Sbjct: 802 AYFKQL-----------DELEKVIKTKEEWVKHTSISESS--RQSLPSLKDSCQRELTNL 848
Query: 2728 ERYHKK----------LIRLPLPDD----------------EHDLSDRELELEDSAALSD 2761
H K L+ P D + + DR+ LE+
Sbjct: 849 LGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQP 908
Query: 2762 LHWHDRSA----DSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD--YDL 2815
H + + D L + + +SL++ L ++D I LE + L
Sbjct: 909 GHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEI-LENQKPALHKL 967
Query: 2816 SRDLESAMSRALPSED----EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRF 2871
+ + ++ P + +E D + + + V +S D LE +I +A +
Sbjct: 968 AEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLE-EIALTLRAFEADST 1026
Query: 2872 QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 2931
I++ + ++ G + L +CS+ ++ ++ +E LK +E NL
Sbjct: 1027 VIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE---TNL 1083
Query: 2932 HS---------TETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGD 2982
S +T+ + E L + +++ R+ ++ +K DL + W+
Sbjct: 1084 RSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQ 1143
Query: 2983 TEEE-LEQLQRLELSTDIQTIELQIKKLKE--LQKAV------DHRKAIILSINLCSPEF 3033
EEE LE+ + ++++ ++K+ KE LQK V D+ K + + E
Sbjct: 1144 AEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQEL 1203
Query: 3034 TQADSKESRDLQDRLSQMNGRWDRVCSLLEE-----------------WRGLLQDALMQC 3076
T + + Q +++ G+ C LEE W L++ +
Sbjct: 1204 TSELNVVLENYQLLCNRIRGK----CHTLEEVWSCWIELLHYLDLETTWLNTLEERMKST 1259
Query: 3077 QGFHEMSHGLLLMLENIDR-------RKNEIVPIDSNL-DAEILQDHHKQLMQIKHELLE 3128
+ E + + LE+++ + +I + L D IL D ++ K E
Sbjct: 1260 EVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDD----IISEKLEAFN 1315
Query: 3129 SQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 3188
S+ S S Q+ + + E + + V+ L L K+++ ++ + V
Sbjct: 1316 SRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQ 1375
Query: 3189 SQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGS 3248
Q + + SA EL T N + P ++SP SR+ +GGS
Sbjct: 1376 EAQKIQAEISAHEL--------TLEELRRNMRSQP------------LTSPESRTARGGS 1415
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/289 (20%), Positives = 133/289 (46%), Gaps = 32/289 (11%)
Query: 2907 SIDSVKRLE-----HKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQ 2961
+ID+++ +E +K + EEE+ +N+ ST + + E +A+ S +
Sbjct: 259 TIDAIREVETLPRKYKKECEEEA----INIQSTAPE-----EEHESPRAETPSTVTEVDM 309
Query: 2962 NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKA 3021
+L +Q L + WL E+ ++ ++S D++ ++ Q + + ++
Sbjct: 310 DLDSYQ---IALEEVLTWLLSAEDTFQEQD--DISDDVEEVKDQFATHEAFMMELTAHQS 364
Query: 3022 IILSI----NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 3077
+ S+ N + T +D +E ++Q++++ +N RW+ + + + L D LM+ Q
Sbjct: 365 SVGSVLQAGNQLITQGTLSDEEEF-EIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQ 423
Query: 3078 --GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA-EILQDHHKQLMQIKHELLESQLRVA 3134
++S L L E I +K E P+D ++ + + L + HK L + +L Q++V
Sbjct: 424 KKQLQQLSAWLTLTEERI--QKMETCPLDDDVKSLQKLLEEHKSL---QSDLEAEQVKVN 478
Query: 3135 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 3183
SL M + N+ + ++++ +G R + + L+++
Sbjct: 479 SLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEI 527
Score = 38.1 bits (87), Expect = 0.15
Identities = 104/559 (18%), Positives = 216/559 (38%), Gaps = 84/559 (15%)
Query: 85 QLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMI 144
QL + L Q L ++ D A+TEKL+ + + + +Q EL ++ +L MI
Sbjct: 2282 QLDYVFTLAQNLKNKASSSDMRT-AITEKLERVKNQW---DGTQHGVELRQQ--QLEDMI 2335
Query: 145 KIRLQ---NLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLS 201
LQ + ++ + M+K+EA L LQ A LT L ++L ++
Sbjct: 2336 IDSLQWDDHREETEELMRKYEARLYILQQARRDP---LTKQISDNQILLQELGPGDGIVM 2392
Query: 202 EMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAV 261
+++ K+ + E L + + L++ + Q+ + +QA+
Sbjct: 2393 AFDNVLQKLLEEYGSDDTRNVKETTEY---LKTSWINLKQSIADRQNALEAEWRTVQASR 2449
Query: 262 VQYEQYEQEMKHLQQ----LIEGAHRE--IEDKPVATS---NIQELQAQISRHEELAQKI 312
E + + ++ + L++ +HRE ++D +A +Q++QA+I H ++ + I
Sbjct: 2450 RDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSI 2509
Query: 313 KGYQEQIASLNSKCKMLTM---------------KAKHATMLL-----------TVTEVE 346
G ++++ + TM KAK A++ + +E
Sbjct: 2510 DGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLE 2569
Query: 347 GLAEGTEDLDGEL---LPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC 403
L + D EL +P P++ + C L + E+
Sbjct: 2570 ELIKWLNMKDEELKKQMPIGGDVPAL-QLQYDHCKALRRELKEKEYS------------- 2615
Query: 404 RSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGD 463
V N +V+Q + E + + T + E + + + +
Sbjct: 2616 -----VLN---AVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSE 2667
Query: 464 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 523
++ WE+L V S Q+ + +ALE+ + Q ++ + ++K +ES G P
Sbjct: 2668 VKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDA-----DMKEAESVRNGWKPVGD 2722
Query: 524 MA--EHQALMDEILMLQDEINELQSSL--AEELVSESCEADPAEQLALQSTLTVLAERMS 579
+ Q +++I+ ++EI + + +L S+ D L + L L R
Sbjct: 2723 LLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWK 2782
Query: 580 TIRMKASGKRQLLEEKLND 598
+++ + + L+E D
Sbjct: 2783 LLQVSVDDRLKQLQEAHRD 2801
Score = 33.9 bits (76), Expect = 2.8
Identities = 115/624 (18%), Positives = 230/624 (36%), Gaps = 90/624 (14%)
Query: 2511 SMERRLKIEETWRLWQKF--LDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 2568
S ++ +K+ RL F Y E L + P +I + FE
Sbjct: 198 SWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTS----LFEV 253
Query: 2569 FQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRL 2627
+QV + + ++E + ++Y++ E + + + HE + VT + L
Sbjct: 254 LPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRA--ETPSTVTEVDMDL 311
Query: 2628 KHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC--DVQAKIKQLKAFQQEISLNHN 2685
+ ++ A + +L WL + + S+ +V+ + +AF E++ + +
Sbjct: 312 -------DSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQS 364
Query: 2686 KIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQ----EVFGRVERYHKKLIRLPL 2739
+ ++ G QLI + D I+E++ L + E R R H L+ L
Sbjct: 365 SVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQK 424
Query: 2740 PDDEH-----DLSDRELELEDSAALSD--------LHWHDRSADSLLSPQPSSNLSLSLA 2786
+ L++ ++ ++ L D L H L + Q N SL+
Sbjct: 425 KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVN-SLTHM 483
Query: 2787 QPLRSERSGRDTPASVDS---------------IPLEWDHDYDLS---RDL--ESAMSRA 2826
+ E SG A ++ W+ +++ ++L E + +A
Sbjct: 484 VVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKA 543
Query: 2827 LPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPT 2886
+E EE + + D L +R+L +D + Q + +
Sbjct: 544 WLTEKEEALN------KVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV 597
Query: 2887 GPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV-NLHSTETQTAGVIDRW 2945
G LD S K K+ + L +L++ + V L ++ +++
Sbjct: 598 GQLLDNS-KASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETV 656
Query: 2946 ELLQAQALSKELRMKQNL-----QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ 3000
++ QA++K + KQ L K +Q + D+ + + + E L + L+ T IQ
Sbjct: 657 R-VREQAITK--KSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI--LKWKTAIQ 711
Query: 3001 TIELQ-----------IKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE---SRDLQD 3046
T E++ KKLK L+K R +N + KE + ++++
Sbjct: 712 TTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKN 771
Query: 3047 RLSQMNGRWDRVCSLLEEWRGLLQ 3070
L +++ W V LE+ +Q
Sbjct: 772 VLEKVSSEWKNVSQHLEDLERKIQ 795
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 136 bits (343), Expect = 3e-31
Identities = 364/1854 (19%), Positives = 726/1854 (39%), Gaps = 205/1854 (11%)
Query: 25 IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSAS 84
+ K EL Q+ + +L L Q A L N L+L G A
Sbjct: 461 LSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQL------------QGDSAQGQKE 508
Query: 85 QLREQYILHQTLLEESKEIDSELEA-MTEKLQYLTSVYCTEKMSQQVAELGRETE-ELRQ 142
+ +E+ L E +E+ LEA +E L L ++ + S EL R+ + E+
Sbjct: 509 EQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTA 568
Query: 143 MIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSE 202
+ Q++ + + + E+ L+AA + A + + ++ L +QL L E
Sbjct: 569 ALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ---LEEE 625
Query: 203 MESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVV 262
+S+ +++A + ++AL++ L A R + + H Q +Q A
Sbjct: 626 NQSVCSRMEAAEQARNALQVD--------LAEAEKRREALWEKNTHLEAQ----LQKAEE 673
Query: 263 QYEQYEQEMKHLQQLIEGAHREIED----KPVATSNIQELQAQISRHEELAQKIKGYQEQ 318
+ + +++ +Q+ E +++ + + AT+ +++L + R EE+ + QE+
Sbjct: 674 AGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLAR--AVQEK 731
Query: 319 IASLNSKCKM-LTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRC 377
A + K + + ++A +++GL+ E L+ L + SV+ +T G+
Sbjct: 732 EALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN-SVIEVTKGQL 790
Query: 378 HTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAK 437
+ VT+ +E E+ + + A +D A Q AE+
Sbjct: 791 EVQIQTVTQ--AKEVIQGEVR---CLKLELDTERSQAEQERDAAARQLAQAEQ------- 838
Query: 438 IHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQ-KYQDSL 496
T+ Q+ + + ++ L+ WE ++ ++ E+LER++ + + L
Sbjct: 839 -EGKTALEQQ------KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRL 891
Query: 497 QSISTKMEAIELKLSESPEPGRSPESQMA-----EHQALMDEILMLQDEINELQSSLAEE 551
+ T+MEAI+ + E S QM E +L++ +L Q E+ + L E
Sbjct: 892 KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQL-ER 950
Query: 552 LVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQ----LLEEK---LNDQLEEQR 604
L + EQ T L E ++ A R L EE L D+++ Q+
Sbjct: 951 LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQK 1010
Query: 605 QEQALQRYRCEADELDSWL-LSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVA 663
Q + L+ D+ + + L + ++E + L+E EQ+++
Sbjct: 1011 QVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLV 1070
Query: 664 LSEL-SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLN-MQGTAQEK 721
L E S+ + L + + + ++ G+ + L + L++ + +K+ + + AQ
Sbjct: 1071 LQEADSIRQQEL-----SALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLL 1125
Query: 722 EESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKEL---EQE---LAEQKSLLRSV 775
EE + Q W +A+ Q R S + Q E EQ+ A+ ++ L S+
Sbjct: 1126 EELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASL 1185
Query: 776 ASRGEEIL--IQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTK 833
S ++ L + S E SG P V E G +S + + S S
Sbjct: 1186 YSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASAL 1245
Query: 834 QKLLQNVLEQEQEQ-VLYSRPNRL---LSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV 889
KL Q++ + +Q + VL + +L L+ K V T+ + L L+Q EE
Sbjct: 1246 HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTE----LQDLQRQLSQNQEEK 1301
Query: 890 SSQSGGAKRQSIHLE-QKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAK 948
S G K+ S+ E +L++ +++ + L E + A E E +E L
Sbjct: 1302 SKWEG--KQNSLESELMELHETMASLQSRLRRAELQRMEAQG----ERELLQAAKENLTA 1355
Query: 949 DIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQ 1008
++ + + + + S A ++E+ L L L N+ +ER Q
Sbjct: 1356 QVEHLQAAVVEARAQASAA--------GILEEDLRTARSALKLK----NEEVESERERAQ 1403
Query: 1009 QILNFQNDLKVLF-TSLADNKYIILQKLANVFEQ--PVAEQIEAIQQAEDGLKE-FDAGI 1064
L Q +LKV +L +N ++ Q LA E+ + QI+ +++ + K +
Sbjct: 1404 A-LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLS 1462
Query: 1065 IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 1124
++LK+R ++ ++Q +QEL K + + + L M + R L + E+ + +
Sbjct: 1463 LDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRN 1522
Query: 1125 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKI---ISFAVQ 1181
+LE ++ ++I S + ++Q L K+ LE + E K+ +
Sbjct: 1523 VLEHQLLELEKKDQMIESQRGQVQDL----KKQLVTLECLALELEENHHKMECQQKLIKE 1578
Query: 1182 KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGL 1241
E Q T+ +A L +R EL+ L+ L+R+L+ + + S
Sbjct: 1579 LEGQRETQRVALTHLTLD-LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
Query: 1242 VEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLES---QLNQLGE 1298
E R + +T + Q + QVL+D + I DLE L + G
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR 1697
Query: 1299 CWLSNTNKMSK--------------ELHRLETILKHWTRYQSESADLIHWLQSAKDRLEF 1344
+ M + L ++ IL+ + + IH LQ KD+LE
Sbjct: 1698 ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ 1757
Query: 1345 WTQ--------QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 1396
Q S+ + Q + + E ++ + + S L + L +
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817
Query: 1397 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQK 1456
+ L+ E + Q + A+Q L Q M L RH + E +
Sbjct: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHM-TLKERHGELQ-----DHKEQARRL 1871
Query: 1457 DEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDF 1516
+E+ +A+ E L + + L + Q Q +VE++
Sbjct: 1872 EEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ--QQCAEQAQEHEVETR------- 1922
Query: 1517 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRL------- 1569
A+ SW Q ++ E+ Q LE L + + + E ++ L
Sbjct: 1923 -----ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAAL 1977
Query: 1570 --KQQHRIGDQASVQNALK----DCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI 1623
K+QH + +QA + +L+ Q D +A +++E+ + IQ++
Sbjct: 1978 QGKEQHLL-EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQED 2036
Query: 1624 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL 1683
V + L Q L H + ++L KS+ ++ +++ + +L + R
Sbjct: 2037 VQQLQQALAQRDEELRHQQEREQLLEKSLA----------QRVQENMIQEKQNLGQER-- 2084
Query: 1684 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 1743
E ++ +++ LQ L ++E+ + + + E P + T+ ++E +++
Sbjct: 2085 --EEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK--TSPMEEQSLK 2140
Query: 1744 WNNLLEEIAEQLQSSKALLQLWQ----RYKDYSKQCASTVQQQEDRTNELLKAA 1793
++L + +L+ +A L+ + +++ ++ A ++ Q + + L + A
Sbjct: 2141 LDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVA 2194
Score = 100 bits (248), Expect = 3e-20
Identities = 483/2524 (19%), Positives = 940/2524 (37%), Gaps = 394/2524 (15%)
Query: 568 QSTLTVLAERMSTIRMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLST 626
QS VL E++ ++ + + + KL N Q +QRQ +++ + + + SW
Sbjct: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
Query: 627 KATLDTALSP-PKEPMDMEAQLMDCQNMLVEIE---QKVVALSE----LSVHNENLLLEG 678
+ L+ P P+ ++E +D +LV +E Q+ +L+E L +H E +
Sbjct: 74 EKRLEATGGPIPQRWENVEEPNLD--ELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVN 131
Query: 679 KAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQE 738
KA +++ E+L R + L+ + +Q +G + + + L +
Sbjct: 132 KA-LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRH 190
Query: 739 WLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA--- 795
+L T ++L + AE L S+ + + + + E +G
Sbjct: 191 FLEMKSAT-----------DRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD 239
Query: 796 GEKPDVL------SQELGMEGEKSSAE-DQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 848
G +P L +QEL E + S E Q++ + + E + L +L Q Q+Q
Sbjct: 240 GREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQN 299
Query: 849 L-YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKL 907
Y + + L + V L + E +S S A+ + + L+Q +
Sbjct: 300 EDYEKMIKAL--------------RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVI 345
Query: 908 YDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQA 967
D T ++ EE + I E S E+D + +FSQ
Sbjct: 346 KD------------------ITQVMVEEGDN------IAQGSGHENSLELDSS--IFSQF 379
Query: 968 FPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADN 1027
++ D L+L+ SV+ +R +++ QQ+ Q +
Sbjct: 380 DYQDADKA-------------LTLVRSVLTRRRQAVQDLRQQLAGCQEAVN--------- 417
Query: 1028 KYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKL 1087
+LQ+ + +E+ + +Q+ ++L+ D L E+ +Q+ +
Sbjct: 418 ---LLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREE 474
Query: 1088 QDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEI 1147
E++ R +N L L+ D + +E+ + + V +E +
Sbjct: 475 LRQQLEVLEQEAWRLRRVNVELQLQG----------DSAQGQKEEQQEELHLAVRERERL 524
Query: 1148 QQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAHK 1203
Q++L GLE+ +E+L I + + EL+ Q +A L RA +
Sbjct: 525 QEML-------MGLEAKQ--SESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 1204 RGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSL 1263
EL E + + EV + +V L NE +D++ L Q L
Sbjct: 576 SIAELS------------SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLE 623
Query: 1264 NEYQPKLYQV-LDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 1322
E Q ++ + R + + ++ E + L W NT+ + +L + E +
Sbjct: 624 EENQSVCSRMEAAEQARNALQVDLAEAEKRREAL---WEKNTH-LEAQLQKAE---EAGA 676
Query: 1323 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 1382
Q++ D+ + + +L Q +LE + +E Q + +
Sbjct: 677 ELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLH----------QEAKRQEEVLAR 726
Query: 1383 VLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISE 1442
+ L+R K A L L ++ DL E+L L K ++ E
Sbjct: 727 AVQEKEALVREK----AALEVRLQAVERDRQDLA-------EQLQGLSSAKELLESSLFE 775
Query: 1443 VMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ-- 1500
S++E + K + ++ I Q + + ++ C +L +D Q
Sbjct: 776 AQQQNSVIE--VTKGQLEVQ-------IQTVTQAKEVIQGEVRCLKLELDTERSQAEQER 826
Query: 1501 --ISSQDVESKRSDKTDFAEQLGAMNK-------------SW------QILQGLVTEKIQ 1539
+ Q ++++ KT +Q A K SW + L+ L EK++
Sbjct: 827 DAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME 886
Query: 1540 LLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKE 1599
L L E +E E +Q + TQ + Q ++ + + L+ + +
Sbjct: 887 LEMRLKEQQTEMEA-IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945
Query: 1600 KEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSH 1659
+++E++ Q+ + + + K+++ + I+ + L+E + LK Q
Sbjct: 946 QQLERLRQD-MKVQKLKEQETTGILQTQLQEAQRE--------------LKEAARQHRDD 990
Query: 1660 KVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNL-QDDLEKQERSLQKFGSIT 1718
A + +S L++ + L + L++ V D+ Q L + +++++ R Q++ I
Sbjct: 991 LAALQEESSSLLQDKMDLQK---QVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQ 1047
Query: 1719 NQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAST 1778
+L +E +LT +L E R L E + + Q AL Q Q + K+ ++
Sbjct: 1048 KELERE-----KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQ 1102
Query: 1779 VQ--QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 1836
++ +QE + E A + ++ A+ I + L L + L +
Sbjct: 1103 MELLRQEVKEKEADFLAQEAQLLEELEASHITE-QQLRASLWAQEAKAAQLQLRLRSTES 1161
Query: 1837 QVDASAASAIQSDQLSLSQHLC----ALEQAL---CKQQTSLQAG---------VLDYET 1880
Q++A AA +Q L AL+QAL C+ + L G + +
Sbjct: 1162 QLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN 1221
Query: 1881 FAKSLEALEAWI--VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLD--- 1935
A+SL + + AE + H DL Q+ + L+ Q+ K D +
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASALHKLHQ-DLWKTQQTRDVLRDQVQKLEERLTDTEAEK 1280
Query: 1936 -----RLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990
L +L +L N +E + + + E + LQS L + + + +
Sbjct: 1281 SQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340
Query: 1991 TWMEFLVQTEQKLAVEISGNYQHLLE---QQRAHELFQAEMFSRQQIL-------HSIII 2040
E L ++ L ++ ++E Q A + + ++ + + L S
Sbjct: 1341 GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE 1400
Query: 2041 DGQRLLEQGQ--VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
Q L EQG+ V L LL+ + RG QI++ ++ REM
Sbjct: 1401 RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRG----QIQELEKQREM--- 1453
Query: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158
+K +E+ L + + LQQ +++Q EK + + L
Sbjct: 1454 -QKAALELLSLDLKKRNQ-EVDLQQ-----EQIQELEKC------------RSVLEHLPM 1494
Query: 2159 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKK 2218
A E L + +I+E K E Q+ L L + EK ++ I +++ KK
Sbjct: 1495 AVQEREQKLTVQREQIRELEKDR----ETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
Query: 2219 KL------SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 2272
+L + L ++H ++ +Q KELE + LT L+L + S + A
Sbjct: 1551 QLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ 1610
Query: 2273 I--LNERVELLQRQWEELCHQLSLRRQQIGE--RLNEWAV--FSEKNKELC---EWLTQM 2323
I L +L R+ +E ++ +R+QI E R E +++EL E + +
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVL 1670
Query: 2324 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 2383
E + ++ IL EE +E++K +E +E Q Q M ER + SKA
Sbjct: 1671 EDQRTRQTKIL-EEDLEQIKLSLRER---GRELTTQRQLMQERAEEGKGPSKAQ------ 1720
Query: 2384 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 2443
+H+ ++ + K+++ + +L + L L + ++ + + S
Sbjct: 1721 ---RGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE 1777
Query: 2444 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL--HDCDACATDAECDSIQQATRNLD 2501
+EI + QE + E + S L+ + L D + A E Q +
Sbjct: 1778 QEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVK 1837
Query: 2502 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK-SSERTAAFPSSSGVIYTVAK 2560
+ + + + ++E Q + R E+ L R A G + ++
Sbjct: 1838 EKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897
Query: 2561 EELKKFEAFQRQV------HECLT--------QLELINKQYRRLARENRTDSACSLKQMV 2606
E+ K A Q+Q HE T Q + + K+ + R +S S +
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS-RHQE 1956
Query: 2607 HEGNQRWDNLQ----KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL------QLT 2656
R + LQ K ++ + +H + Q E + S +D QL
Sbjct: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE 2016
Query: 2657 NIEHFSECDVQAK-------IKQLK--AFQQEISLNHNK-----IEQIIAQ--GEQLIEK 2700
E ++Q + ++QL+ Q++ L H + +E+ +AQ E +I++
Sbjct: 2017 EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE 2076
Query: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRL-------------------PLPD 2741
+ L EEE+ L + +E+ + + ++++ L P+ +
Sbjct: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136
Query: 2742 DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS 2801
L E L+ A + + + +L+LSLAQ S S ++
Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
Query: 2802 VDSIPLEWDHDYDLSRDLESAMSRALPSE---DEEGQDDKDFYLRGAVGLS-GDHSALES 2857
+ + LE D + +D RAL E + RG G+ G+ S +E+
Sbjct: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256
Query: 2858 QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 2917
+ G R +++ + + L+ + + S+++ V+R K
Sbjct: 2257 EPSPDGMEKQSWRQRLEHLQQAV-------ARLEIDRSRLQRHNVQLRSTLEQVERERRK 2309
Query: 2918 LKEE 2921
LK E
Sbjct: 2310 LKRE 2313
Score = 83.2 bits (204), Expect = 4e-15
Identities = 202/971 (20%), Positives = 366/971 (37%), Gaps = 196/971 (20%)
Query: 11 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 70
L++ G+L K + + L QT+ + E + L LE+ EM + L+
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALE----- 1459
Query: 71 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 130
+L L + ++E+D + E + E EK +
Sbjct: 1460 --------------------LLSLDLKKRNQEVDLQQEQIQE----------LEKCRSVL 1489
Query: 131 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 190
L +E Q + ++ + +++ KD + L+ LE+ + S LK
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLK 1549
Query: 191 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 250
+QL + L E+E K++ Q L + + L H L L+E + LQ +
Sbjct: 1550 KQLVTLECLALELEENHHKMECQQKLIKELEGQRE-TQRVALTHLTLDLEERSQELQAQS 1608
Query: 251 IQQCNIMQAAVV---QYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEE 307
Q ++ + V + ++ +QE+K ++ IE ELQ Q E
Sbjct: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQIE-----------------ELQRQ---KEH 1648
Query: 308 LAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHP 367
L Q ++ +++ + ++L + T +L EDL+
Sbjct: 1649 LTQDLERRDQELMLQKERIQVLEDQRTRQTKIL-----------EEDLE---------QI 1688
Query: 368 SVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS 427
+ + GR T + +E EEG + PS Q S
Sbjct: 1689 KLSLRERGRELTTQRQLMQERAEEG-----------KGPSKA--------------QRGS 1723
Query: 428 AERLQTDAAKIHPSTSASQEFYE--PGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEA 485
E ++ QE L+ +L L R ++S++++ E
Sbjct: 1724 LEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ---EI 1780
Query: 486 LERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ 545
+ QQ+ Q++ + K ++++ +L E+ + +A+ E+ LQ E + Q
Sbjct: 1781 VVLQQQLQEAREQGELKEQSLQSQLDEA-------QRALAQRD---QELEALQQEQQQAQ 1830
Query: 546 SSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQ 605
EE V E + A Q AL+ L ER ++ R+L EE + Q
Sbjct: 1831 GQ--EERVKEKAD---ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL 1885
Query: 606 EQALQRYRCEADELDSWLLS-TKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVAL 664
E+ L R E+ E + LL+ + + A E ++ + Q +L E +Q++ AL
Sbjct: 1886 EEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL 1945
Query: 665 ---SELSVHNENLLLE---------GKAHTKDEAE-----QLAGKLRRLKGSLLELQRAL 707
S+ S H E GKAH + + + A R L+ S LQ +L
Sbjct: 1946 RAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASL 2005
Query: 708 -----HDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELE 762
H +QL QE E D DL + VQ Q +Q+ Q+ +EL
Sbjct: 2006 DACQAHSRQLEEALRIQEGEIQDQDLRYQED--VQ-----------QLQQALAQRDEELR 2052
Query: 763 QELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMK 822
+ ++ L +S+A R +E +IQ Q LG E E E+++R
Sbjct: 2053 HQQEREQLLEKSLAQRVQENMIQE----------------KQNLGQERE----EEEIR-- 2090
Query: 823 WESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRL---LSGVPLYKGDVPTQDKS-AVTSL 878
LHQ + LQ L Q+++++L R + L +P P +++S + SL
Sbjct: 2091 --GLHQSV----RELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL 2144
Query: 879 LDGLNQAFEEVSSQSGGAKRQSIHLEQKLYD---GVSATSTWLDDVEE-RLFVATALLPE 934
L + E + + + + I +K D ++ T + ++E +F+ ++L
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLER 2204
Query: 935 ETETCLFNQEI 945
++E E+
Sbjct: 2205 DSEQQRLQDEL 2215
Score = 80.9 bits (198), Expect = 2e-14
Identities = 279/1483 (18%), Positives = 581/1483 (39%), Gaps = 267/1483 (18%)
Query: 1780 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLL-----------KGLGTVKDSLFFLH 1828
++ +R+ EL++ + D+ E+ + + + LL K + +++++ L
Sbjct: 258 KEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILE 317
Query: 1829 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGV------------- 1875
+L + +AS + Q ++LSL Q + + Q + ++ ++ G
Sbjct: 318 TNHTELMEH-EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIF 376
Query: 1876 --LDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 1933
DY+ K+L + + + + +Q+ ++L G + +
Sbjct: 377 SQFDYQDADKALTLVRSVLTRRRQ--------------AVQDLRQQLAGCQEAVNLLQQQ 422
Query: 1934 LDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWM 1993
D+ E G L +R+Q L ++ QT + ++ S L + + L+K
Sbjct: 423 HDQWEEEGKALR------QRLQKLTGERDTLAGQTVDLQGEVDS-LSKERELLQKAR--- 472
Query: 1994 EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRL------LE 2047
E L Q + L E + +E Q + Q + +Q+ LH + + +RL LE
Sbjct: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
Query: 2048 QGQVDDRDEF-NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 2106
Q + E L+ L S+ +G + R +Q + + R Q E++ EV
Sbjct: 533 AKQSESLSELITLREALESSHLEGELLRQEQTE-VTAALARAEQSIAELSSSENTLKTEV 591
Query: 2107 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 2166
+ L + + + +E +KV L QQ +L +E Q + S AE A
Sbjct: 592 ADLRAAAV---------KLSALNEALALDKVGLNQQ---LLQLEEENQSVCSRMEAAEQA 639
Query: 2167 ---LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223
LQ +LAE +++ ++ L E+ L L+ E+ + L ++ K+++ +
Sbjct: 640 RNALQVDLAEAEKRREA----LWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695
Query: 2224 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 2283
L + + A + ++L + L + K+ L +A L R++ ++R
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAA-----LEVRLQAVER 750
Query: 2284 QWEELCHQLSLRRQQIGERLNEWAVFSEKNK----ELCEWLTQMESKVSQNGDILIEEMI 2339
++L QL + + L E ++F + + E+ + +++ + +I+ +
Sbjct: 751 DRQDLAEQL--QGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV 808
Query: 2340 EKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 2399
LK + E + A++ + +LA+A E K + + K AA
Sbjct: 809 RCLKLELDTERSQAEQER---DAAARQLAQAEQEGKTALEQQK---------------AA 850
Query: 2400 RVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRD 2459
K+ V QL + R+W + ELAK + E ++R E+ EL+
Sbjct: 851 HEKE-------VNQLREKWEKERSWH---QQELAKAL-------ESLER---EKMELEMR 890
Query: 2460 IEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRN--ICAMSME---R 2514
+++ T + ++ QA R +R +C M +E
Sbjct: 891 LKEQQTEMEAI------------------------QAQREEERTQAESALCQMQLETEKE 926
Query: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPS--SSGVIYTVAKEELKKFEAFQRQ 2572
R+ + ET QK L D S+ + L+ + ++G++ T +E ++ + RQ
Sbjct: 927 RVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ 986
Query: 2573 VHECLTQLELINKQYRRLARENRTDSACSLKQMV-HEGNQRWDNLQKRVTSILRRLKHFI 2631
+ L L+ + + + + Q+V + +QR +++ V LR + +
Sbjct: 987 HRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL--VEQEVQEKLRETQEYN 1044
Query: 2632 GQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQII 2691
++E E + S+ + L E + +L ++ E D QQE+S +++
Sbjct: 1045 RIQKELEREKASLTLSLMEKEQRLLVLQ---EAD--------SIRQQELSALRQDMQEAQ 1093
Query: 2692 AQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYH--KKLIRLPLPDDEHDLSDR 2749
+ ++L + E L + E+E D L + Q + +E H ++ +R L E +
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQ-LLEELEASHITEQQLRASLWAQEAKAAQL 1152
Query: 2750 ELELEDSAA-LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGR-DTPASVDSIPL 2807
+L L + + L L + + + ++L +L Q L S R + DS P
Sbjct: 1153 QLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPS 1212
Query: 2808 EWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALD 2867
W + D+ G + + RG + + A+ S + +L + L
Sbjct: 1213 VWGLE-----------------PDQNGA--RSLFKRGPLLTALSAEAVASALHKLHQDL- 1252
Query: 2868 DSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPG 2927
++ QQT +++R D V++LE +L +
Sbjct: 1253 ---WKTQQTRDVLR---------------------------DQVQKLEERLTD------- 1275
Query: 2928 FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEEL 2987
TE + + V + LQ Q + QN ++ ++ NS+ + L + E +
Sbjct: 1276 ------TEAEKSQVHTELQDLQRQ-------LSQNQEEKSKWEGKQNSLESELMELHETM 1322
Query: 2988 EQLQRLELSTDIQTIELQ-----IKKLKE-LQKAVDHRKAIILSINLCSPEFTQADSKES 3041
LQ ++Q +E Q ++ KE L V+H +A ++ + A
Sbjct: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA----SAAGILE 1378
Query: 3042 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 3101
DL+ S + + + V S E + L + ++ + L L+ + + R+ E+
Sbjct: 1379 EDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVE 1438
Query: 3102 PIDSNL-DAEILQDHHKQLMQ-----IKHELLESQLRVASLQDM-SCQLLVNAEGTDCLE 3154
+ + + E ++ K ++ +K E L+ +Q++ C+ ++ E
Sbjct: 1439 TLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQE 1498
Query: 3155 AKEKVHVIGNRLKLLLK--EVSRHIKELEKLLDVSSSQQDLSS 3195
++K+ V +++ L K E R++ E +LL++ Q + S
Sbjct: 1499 REQKLTVQREQIRELEKDRETQRNVLE-HQLLELEKKDQMIES 1540
Score = 60.8 bits (146), Expect = 2e-08
Identities = 298/1604 (18%), Positives = 608/1604 (37%), Gaps = 229/1604 (14%)
Query: 1718 TNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAS 1777
T +L KE H E L + ++ L + + E S L Q ++ +DY K +
Sbjct: 253 TQELEKEAHERSQE-LIQLKSQGDLEKAELQDRVTEL---SALLTQSQKQNEDYEKMIKA 308
Query: 1778 ---TVQQQEDRTNELLK-AATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 1833
TV+ E EL++ A+ A +E + Q D+ + + D++ G +
Sbjct: 309 LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNI--AQGSGHE 366
Query: 1834 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 1893
++D+S S Q D + L + L +++ ++Q L A
Sbjct: 367 NSLELDSSIFS--QFDYQDADKALTLVRSVLTRRRQAVQ-----------DLRQQLAGCQ 413
Query: 1894 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDL----DRLN----------- 1938
EA +LQ Q + +++R+++L G+ + DL D L+
Sbjct: 414 EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473
Query: 1939 ELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQ 1998
EL +L + ++E R++ +N L + + Q L H E+ E E L+
Sbjct: 474 ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL--HLAVRER-ERLQEMLMG 530
Query: 1999 TEQKL------------AVEISGNYQHLLEQQRAH--------ELFQAEMFSRQQILHSI 2038
E K A+E S LL Q++ E AE+ S + L +
Sbjct: 531 LEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTE 590
Query: 2039 IIDGQRL------LEQGQVDDRDEFNLKLTLLSNQWQGVIRR---AQQRRGIIDSQIRQW 2089
+ D + L + D+ N +L L + Q V R A+Q R + + +
Sbjct: 591 VADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEA 650
Query: 2090 QRYRE-MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILT 2148
++ RE + EK ++ +G + L+ + +E+Q K QQ +
Sbjct: 651 EKRREALWEKNTHLEAQLQKAEEAG-AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709
Query: 2149 VEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD 2208
+E Q EA Q E+ + K A +R +K L L+ E+ + +A+
Sbjct: 710 LEQLHQ---------EAKRQEEVLARAVQEKEALVR---EKAALEVRLQAVERDRQDLAE 757
Query: 2209 SLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTD-------DLTQLSLLKDT 2261
L+ L + K+ L SL + ++ ++ +LE + + T ++ L L DT
Sbjct: 758 QLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
Query: 2262 LSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVF-SEKNKELCEWL 2320
+ + + + + Q L Q + +++ + +W S +EL + L
Sbjct: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
Query: 2321 TQMESKVSQNGDILIEEM--IEKLKKDYQEEIAIAQENKIQLQ---------------QM 2363
+E + + L E+ +E ++ +EE A+ Q+Q Q
Sbjct: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
Query: 2364 GERLAKASHESKASEIEYKLGKVNDR---------WQHLLDLIAARVKKLKETLVAVQQ- 2413
+ LA AS + + + K+ K+ ++ Q + ++ ++ L A+Q+
Sbjct: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
Query: 2414 ---LDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQE---LQRDIEKHSTGV 2467
L ++ L+ + ++S+L +E+Q KL E QE +Q+++E+ +
Sbjct: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
Query: 2468 ASVLNLCE-----VLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETW 2522
L+L E ++L + D+ E +++Q + + + A R +++E
Sbjct: 1058 T--LSLMEKEQRLLVLQEADSIRQQ-ELSALRQDMQEAQGEQKELSAQMELLRQEVKE-- 1112
Query: 2523 RLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL--TQL 2580
+ A F + + EEL+ ++Q+ L +
Sbjct: 1113 ---------------------KEADFLAQEAQLL----EELEASHITEQQLRASLWAQEA 1147
Query: 2581 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQ----REE 2636
+ Q R + E++ ++ + +Q GNQ Q ++ S+ L+ +G R E
Sbjct: 1148 KAAQLQLRLRSTESQLEALAAEQQ---PGNQA--QAQAQLASLYSALQQALGSVCESRPE 1202
Query: 2637 FETARDSI-LVWLTEMDLQ-----LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQI 2690
DS VW E D + +A L Q++ + +
Sbjct: 1203 LSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVL 1262
Query: 2691 IAQGEQLIEKSEPLDA--AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 2748
Q ++L E+ +A + + EL +L+R + ++ K + L + +L +
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK--QNSLESELMELHE 1320
Query: 2749 RELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLE 2808
L+ ++L + + L NL+ + + R ++ +
Sbjct: 1321 TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGIL--- 1377
Query: 2809 WDHDYDLSRDLESAMSRALPSEDEEGQ---DDKDFYLRGAVGLSGDHSALESQIRQLGKA 2865
+ D +R + + SE E Q + + + L + + L + + +
Sbjct: 1378 -EEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEE 1436
Query: 2866 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 2925
++ R QIQ+ E + + L+ K E + ++ LE K + E L
Sbjct: 1437 VETLRGQIQELE---KQREMQKAALELLSLDLKKRNQEVDLQQEQIQELE-KCRSVLEHL 1492
Query: 2926 PGFVNLHSTETQTAGVIDRWELLQAQALSKELR--MKQNLQKWQQFNSDLNSIWAWLGDT 2983
P V E + + R ++ + + + R ++ L + ++ + + S + D
Sbjct: 1493 PMAVQ----EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDL 1548
Query: 2984 EEELEQLQ--RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 3041
+++L L+ LEL + +E Q K +KEL+ + ++ + + L E S
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEE-------RS 1601
Query: 3042 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 3101
++LQ + SQ++ L E + Q+ Q + E+ + ++++RR E++
Sbjct: 1602 QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM 1661
Query: 3102 PIDSNLDAEILQDH--------HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCL 3153
+ ++L+D + L QIK L E + + + + + +G
Sbjct: 1662 LQKERI--QVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719
Query: 3154 EAKEKVHVIGNRLKLLLKEVSR-------HIKELEKLLDVSSSQ 3190
+ H +KL+L++ + HI EL++L D Q
Sbjct: 1720 QRGSLEH-----MKLILRDKEKEVECQQEHIHELQELKDQLEQQ 1758
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 129 bits (325), Expect = 4e-29
Identities = 275/1320 (20%), Positives = 520/1320 (39%), Gaps = 149/1320 (11%)
Query: 1831 GEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEA 1890
GE L Q A Q Q L +H L QA+ + L+ ++ F + ++ EA
Sbjct: 2177 GEALLAQSHPRAGEVSQRLQ-GLRKHWEDLRQAMALRGQELEDR-RNFLEFLQRVDLAEA 2234
Query: 1891 WIVEAEEILQ----GQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL 1946
WI E E + GQD H L + R+ E +G + + +++L +L
Sbjct: 2235 WIQEKEVKMNVGDLGQDLEHCLQL---RRRLREFRGNSAGDTVGDACIRSISDLSLQLKN 2291
Query: 1947 NDKE-----IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQ 2001
D E +R LN W+ +L+ L H E +
Sbjct: 2292 RDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEAL 2351
Query: 2002 KLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKL 2061
A++ + + + R HE + E+ Q + S+ + RL ++ + +
Sbjct: 2352 IQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQ 2411
Query: 2062 TLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPL 2121
+ + WQ + RAQ+RR +D+ + Q Q+ + M ++L LV L + + + P P
Sbjct: 2412 EVAESWWQ-LRSRAQKRREALDA-LHQAQKLQAMLQEL---LVSAQRL-RAQMDTSPAPR 2465
Query: 2122 Q--QARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAE------AALQAELAE 2173
+AR + +E Q + S L G+QLL + + A L+ EL+
Sbjct: 2466 SPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSS 2525
Query: 2174 IQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHA 2233
++ W+ ++L+ Q +L L EK E+ + + L S+ L D +
Sbjct: 2526 LEGAWQEHQLQLQ-QALELQLFLSSVEKMERWLCSKEDSLA------SEGLWDPLAPMEP 2578
Query: 2234 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
+ K LE + ++ L L + S L +L R+ E L Q
Sbjct: 2579 LLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRK-EALFRQAG 2637
Query: 2294 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKK--DYQEEIA 2351
RR ++ E L + F + ++E+ WL + + G + + +L+K ++Q E+
Sbjct: 2638 TRRHRL-EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELD 2696
Query: 2352 IAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAV 2411
+ + +LQ+ G+RL + H + + I+ +L ++ W L D +V KL++ A+
Sbjct: 2697 ASMHQQQELQREGQRLLQGGHPA-SEAIQERLEELGALWGELQDNSQKKVAKLQKACEAL 2755
Query: 2412 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 2471
+L ++M L WL IE EL P V + + L Q+EL+ ++K + ++L
Sbjct: 2756 -RLRRSMEELENWLEPIEVELRAPTVGQALPG--VGELLGTQRELEAAVDKKARQAEALL 2812
Query: 2472 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 2531
+ + + A D +++ R L +R++++ ERR +E L KF D
Sbjct: 2813 GQAQAFVREGHCLAQD-----VEEQARRLLQRFKSLREPLQERRTALEAR-SLLLKFFRD 2866
Query: 2532 YSRFEDWLKSSERTAAFPSSSGVIYTV--AKEELKKFEAFQRQVHECLTQLELINKQYRR 2589
W++ AA + V +E+ + E+ + HE LT++ ++ Y+
Sbjct: 2867 ADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLES-EMSSHEALTRV-VLGTGYKL 2924
Query: 2590 LARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI---LRRLKHFIGQREEFETARDSIL- 2645
+ + HE R L+K + + R + + Q +E + +L
Sbjct: 2925 VQAGHFA---------AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLE 2975
Query: 2646 --VWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKS 2701
WL E L ++ H +E QA +++L+A ++++ +IE+ + Q L+E
Sbjct: 2976 AGSWLAERGHVLDSEDMGHSAEA-TQALLRRLEATKRDLEAFSPRIER-LQQTAALLESR 3033
Query: 2702 EPLDAAIIEEELDELRRYCQEVFGRVE-RYHKKLIRLPLPDDEHDLSDRELELEDSAALS 2760
+ ++ + +L +R E+ R E R H +L L E + + L AA +
Sbjct: 3034 KNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATA 3093
Query: 2761 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER--SGRDTPASVD-SIPLEWDHDYDLSR 2817
+ + + + + + + Q L + + R +++ P + H
Sbjct: 3094 ESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRS 3153
Query: 2818 DLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTE 2877
+E+A R L A+ ++ A ++ +A + + ++Q+
Sbjct: 3154 RIEAAWER----------------LDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKT 3197
Query: 2878 NIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 2937
+++ + G SS+ ++++ +L+ E E++ V TE
Sbjct: 3198 ALMKGEDG----------------GHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEAC 3241
Query: 2938 TAG------------VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW------ 2979
G V + W LQA+A + + Q Q F + AW
Sbjct: 3242 RLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ-GHAFLGRCQELLAWAQERQE 3300
Query: 2980 LGDTEEELEQL--------QRLELSTDIQTIELQIKKLK-ELQKAVDHRKAIILSINLCS 3030
L +EE E + Q EL +I+ LQ + L+ E Q+ VD+ + + C
Sbjct: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
Query: 3031 PEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL--LQDALMQCQGFHEMSHGLLL 3088
E L+ RL ++ W E GL L+ L Q + + GLLL
Sbjct: 3361 QE-----------LEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLL 3409
Score = 125 bits (314), Expect = 7e-28
Identities = 569/2863 (19%), Positives = 1086/2863 (37%), Gaps = 453/2863 (15%)
Query: 29 TELHQ-QTI-RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQL 86
+ LHQ QT+ R+ L +L + +Y +++ +L+WI + ++ QL
Sbjct: 247 SRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQM------------QL 294
Query: 87 REQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKI 146
E+++ L AM + L T EK + E R +
Sbjct: 295 ------------EARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTAL 342
Query: 147 RLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESL 206
+ QN + AEL + A LE A+A + + L R L +E+L
Sbjct: 343 QAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS----------QALQQRLLQLQRLETL 392
Query: 207 KPKVQ-AVQLCQSALRIPEDVV-------ASLPLCHAALRL--QEEASRLQHTAIQQCNI 256
+ Q L +S L+ E V+ ASL AA++ EA L Q
Sbjct: 393 ARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALA 452
Query: 257 MQAAVVQYEQYEQ-------------EMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 303
A +++ EQY + L Q ++G +++ D S +QE++A
Sbjct: 453 EIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASH 512
Query: 304 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT----EVEGLAEGTEDLDGEL 359
+ EEL + + A +++ + +H + V+ V LA+ T +LD L
Sbjct: 513 QLEELQEPAR----STACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSL 568
Query: 360 LPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQD 419
GT+ E+ A +A S+
Sbjct: 569 --------------------------------GTSVEVLQAKA----RTLAQLQQSLVAL 592
Query: 420 IAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLG-DLQRSWETLKNVISEK 478
+ +AL + LQ A+ + + + + + A LG DL + L +K
Sbjct: 593 VRARRALLEQTLQ--RAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGAL-----QK 645
Query: 479 QRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQ 538
+ L + R Q L + A + P+PG E+ Q +LQ
Sbjct: 646 HKALEAEVHRHQAVCVDLVRRGRDLSA--RRPPTQPDPGERAEAVQGGWQ-------LLQ 696
Query: 539 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 598
+ + L L+ AD AE + L ER S++ + G+ Q E L
Sbjct: 697 TRVVGRGARLQTALLVLQYFADAAE------AASWLRERRSSLERASCGQDQAAAETL-- 748
Query: 599 QLEEQRQEQALQRYRCEADELDSWLLSTKA-----TLDTALSPPKEPMDMEAQLMD--CQ 651
R E+ L+ + E L+ + A T+++ALSPP E + + C
Sbjct: 749 LRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCH 808
Query: 652 NMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQ 711
+ + + + N +L+ + H + E L +L +L+RA ++
Sbjct: 809 PGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLR--------ALAQLRRARLEEA 860
Query: 712 LNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ--QRQSSLQQQKELEQE----- 764
+ + G E +Q WL + +T Q Q Q+ + +L+ E
Sbjct: 861 MALFGFCSSCGE------------LQLWL-EKQTVLLQRVQPQADTLEVMQLKYENFLTA 907
Query: 765 LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG-MEGEKSSAEDQMRMKW 823
LA K L V+S E++ ++ T + + LSQ G +E K Q+
Sbjct: 908 LAVGKGLWAEVSSSAEQLRQRYPGNST--QIQRQQEELSQRWGQLEALKREKAVQLAHSV 965
Query: 824 E--SLHQEFSTKQKLLQNV--------------------LEQEQEQVLYSRPNRLLSGV- 860
E S QE Q L++V L Q++ VL R + L S V
Sbjct: 966 EVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVV 1025
Query: 861 ----PLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-IHLEQKLYDGVSATS 915
P Y P Q + V +L L Q E+V+ + A+RQ+ Q
Sbjct: 1026 KVEEPGYAESQPLQGQ--VETLQGLLKQVQEQVAQR---ARRQAETQARQSFLQESQQLL 1080
Query: 916 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFP-- 969
W + V+ + L +E + + + L ++ +++ EE+ ++ + L +Q+ P
Sbjct: 1081 LWAESVQAQ------LRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA 1134
Query: 970 --ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADN 1027
+ D+++V +TL L + L + QR ++E L ++ F ++ + A++
Sbjct: 1135 ALDCPDSQEV-PNTLRVLGQQGQELKVLWEQRQQWLQEGL-ELQKFGREVDGFTATCANH 1192
Query: 1028 K-YIILQKLANVFEQPVAEQIEAIQQAEDG---LKEFDAGIIELKRRGDKL-QVEQPS-- 1080
+ ++ L L + V E + +QQ + L L+ G+KL Q + P+
Sbjct: 1193 QAWLHLDNLG----EDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248
Query: 1081 --MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 1138
++L +Q + L RR L +L Q + QD+A+L++ +EK
Sbjct: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASL----QLQEWKQDVAELMQWMEEKGLMAAH 1304
Query: 1139 IIVSSKEEIQQLLDKHKEYFQGL---ESHMILTETLFRKIISFAVQKETQFHTELMAQAS 1195
++ I Q L +H+ L H+ + + R+++S + T L S
Sbjct: 1305 EPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRS 1364
Query: 1196 ---AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV-GLVEENEDRLID 1251
A+ ++ +RG EL+ Q++L RQL+ + + + G ++ +E
Sbjct: 1365 KWEALNRKMTERGDELQQA--------GQQEQLLRQLQDAKEQLEQLEGALQSSETG--- 1413
Query: 1252 RITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKEL 1311
Q L+SS + K +Q L+ R L + + L S + + + + K L
Sbjct: 1414 -----QDLRSS--QRLQKRHQQLESESRTL-AAKMAALASMAHGMAAS-PAILEETQKHL 1464
Query: 1312 HRLETILKHWT--RYQSESADLIHWLQSAKDRLEFWTQQSV------TVPQELEMVRDHL 1363
RLE + H Q +++ +H + W + + + + L +
Sbjct: 1465 RRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
Query: 1364 NAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQ 1423
E EV A VLS+G L + + ++ W +L A
Sbjct: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARA 1584
Query: 1424 EKLHQ---LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGF 1480
+ L Q Q L +SE+ W+ ++ + + + I+ K++
Sbjct: 1585 QCLQQAVTFQQYFLD----VSELEGWVEEKRPLVSSRDYGRDEAATLRLIN----KHQAL 1636
Query: 1481 KIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 1539
+ ++ +++ ++Q+ ++ +V E +R + EQL A LQ L + +
Sbjct: 1637 QEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA-------LQELAATRDR 1689
Query: 1540 LLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKE 1599
LEG L E+ + L+ W +Q++ K +G+ ++AL C E
Sbjct: 1690 ELEGTLR-LHEFLREAEDLQGWLASQKQAAKGGESLGEDP--EHALHLCTKFAKFQHQVE 1746
Query: 1600 KEVEKIEQNGLAL--IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWS 1657
+++ L + + +V ++L W+ L + L+ D +
Sbjct: 1747 MGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR---DTET 1803
Query: 1658 SHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSI 1717
+ +V D + + S + L ++ Q+ + Q L+ +L ER LQ+
Sbjct: 1804 TLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLET 1863
Query: 1718 TNQLLKECHPPVTETLTNTLKEVNMRWNNL---LEEIAEQLQSSKALLQLWQRYKDYSKQ 1774
++ K C P + + V W L +E+ QL+ ++ L + +DY+
Sbjct: 1864 AGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASW 1923
Query: 1775 CASTVQ--QQEDRTNE----LLKAATNKDIADDEVA---TWIQDC---NDLLKGLGT--- 1819
A Q Q E+ + E LK + ++ + + A W Q L GT
Sbjct: 1924 AARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTK 1983
Query: 1820 -VKDSLFFLHELGEQLKQ--QVDASAASAIQSDQLSLSQHLCA-LEQALCKQQTSLQAGV 1875
V++ L L + +Q+ Q A Q +QL L + C LE+ L Q+ SL+
Sbjct: 1984 EVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE--CGRLEEILAAQEVSLKTSA 2041
Query: 1876 LDYETFAKSLEALEAWIVEAE---EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAP 1932
L S+E +E I + E ++L QD ++ ++ER++ L+ ++
Sbjct: 2042 L-----GSSVEEVEQLIRKHEVFLKVLTAQDKKEAA----LRERLKTLRRPRVR------ 2086
Query: 1933 DLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 1992
DRL L R + KE+ + H SL+ + T+ ++ + ++ + W
Sbjct: 2087 --DRLPILLQR-RMRVKELAESRGHALHASLLMASFTQAATQAEDWI----------QAW 2133
Query: 1993 MEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVD 2052
+ L + G+ + L+ H+ F+AE+ + ++++ S+ G+ LL Q
Sbjct: 2134 AQQLKEPVP------PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSH-P 2186
Query: 2053 DRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMS 2112
E + +L L W+ +R+A RG R + + + + W+ E
Sbjct: 2187 RAGEVSQRLQGLRKHWED-LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEV--KM 2243
Query: 2113 GLGSVPIPLQQARTLFDEV-QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE- 2170
+G + L+ L + +F+ G + + L L E + +
Sbjct: 2244 NVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQR 2303
Query: 2171 LAEIQEKWKSAS---MRLEEQKK---KLAFLLKDWEKCEKGIADSLEKLRTFK-----KK 2219
+++ +W S +R ++Q + ++ L ++ + K I + ++ +
Sbjct: 2304 RSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLES 2363
Query: 2220 LSQSLPDHHE---ELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNE 2276
+ + L H E E+H Q + + LE VG S + L
Sbjct: 2364 VQRLLRKHEELEREVHPIQAQVESLEREVGRLCQR---------------SPEAAHGLRH 2408
Query: 2277 RVELLQRQWEELCHQLSLRR---------QQIGERLNEWAVFSEKNKELCEWLTQMESKV 2327
R + + W +L + RR Q++ L E V +++ + QM++
Sbjct: 2409 RQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR------AQMDTSP 2462
Query: 2328 SQNGDILIEEMIEKLKK------DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEY 2381
+ + M+E+ ++ + + I++A+ QL G + + A +E
Sbjct: 2463 APRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAG-LEQ 2521
Query: 2382 KLGKVNDRWQ-HLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 2440
+L + WQ H L L + +L+ L +V+++++ WL E LA ++D
Sbjct: 2522 ELSSLEGAWQEHQLQL--QQALELQLFLSSVEKMER-------WLCSKEDSLASEGLWDP 2572
Query: 2441 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNL 2500
++ L + + L+ D+E + G S L LH E S + +
Sbjct: 2573 L--APMEPLLWKHKMLEWDLEVQA-GKISALEATARGLHQ----GGHPEAQSALGRCQAM 2625
Query: 2501 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VA 2559
R + + RR ++EE +L Q FL D WL+ A G++ T +
Sbjct: 2626 LLRKEALFRQAGTRRHRLEELRQL-QAFLQDSQEVAAWLREKNLVAL---EEGLLDTAML 2681
Query: 2560 KEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRW----DN 2615
+L+K + FQ ++ + Q + + ++ +RL + S ++++ + E W DN
Sbjct: 2682 PAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASE-AIQERLEELGALWGELQDN 2740
Query: 2616 LQKRVTSILRRLKHFIGQR--EEFETARDSILVWLTEMDL--------QLTNIEHFSECD 2665
QK+V + + + +R EE E + I V L + +L + E
Sbjct: 2741 SQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAA 2800
Query: 2666 VQAKIKQLKAF----QQEISLNHNKIEQIIAQGEQLIEKSEPL 2704
V K +Q +A Q + H + + Q +L+++ + L
Sbjct: 2801 VDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSL 2843
Score = 117 bits (292), Expect = 2e-25
Identities = 297/1588 (18%), Positives = 617/1588 (38%), Gaps = 214/1588 (13%)
Query: 1220 EDQQELSRQLEVVESSIPS--VGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 1277
++ Q+L E V++ + S V + + RL+ +Q L ++ +Q +L Q LD
Sbjct: 1074 QESQQLLLWAESVQAQLRSKEVSVDVASAQRLLRE---HQDLLEEIHLWQERLQQ-LDAQ 1129
Query: 1278 KRLLISISCSD----------LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSE 1327
+ + ++ C D L Q +L W + + L L+ + + +
Sbjct: 1130 SQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTAT 1188
Query: 1328 SADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTG 1387
A+ WL D L V + L +++ H EF + + ++ + G
Sbjct: 1189 CANHQAWLHL--DNL------GEDVREALSLLQQHR----EFGRLLSTLGPRAEALRAHG 1236
Query: 1388 NQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL-HQLQMDKLPSRHAISEVMSW 1446
+L++ + T+R +L I +QWT L + +L LQ+ + + ++E+M W
Sbjct: 1237 EKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEW--KQDVAELMQW 1294
Query: 1447 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 1506
+ + + + +I + L++++ + ++ + V+ ++ Q+ + +
Sbjct: 1295 MEEKGLMAAHEPSGARRNI-----LQTLKRHEAAESELLATRRHVE----ALQQVGRELL 1345
Query: 1507 ESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 1566
+ + D +L + W+ L +TE+ L+ + + +Q K E E
Sbjct: 1346 SRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQ-EQLLRQLQDAKEQLEQLE 1404
Query: 1567 KRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMS 1626
L+ D S Q K Q LE E + LA + + +I+
Sbjct: 1405 GALQSSETGQDLRSSQRLQKRHQQLES-----ESRTLAAKMAALASMAHGMAASPAILEE 1459
Query: 1627 TLRELGQTWANLDHM-VGQLKILLKSVLDQ----------WSSHKVAFDKINSYLMEARY 1675
T + L + H+ + L++ L Q W + + SY
Sbjct: 1460 TQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSY------ 1513
Query: 1676 SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTN 1735
T L Q + LQ +++ + +Q+ S L HP + +
Sbjct: 1514 --------TECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQA-QHIVE 1564
Query: 1736 TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN 1795
+E+ W L + Q + + Q + D V + E E ++
Sbjct: 1565 QCQELEGHWAELERACEARAQCLQQAVTFQQYFLD--------VSELEGWVEEKRPLVSS 1616
Query: 1796 KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQL---- 1851
+D DE AT L+ +++ L E+L Q + Q
Sbjct: 1617 RDYGRDEAATL-----RLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQE 1671
Query: 1852 SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQG-----QDPSH 1906
L + L AL++ + L+ G L F + E L+ W+ ++ +G +DP H
Sbjct: 1672 RLREQLRALQELAATRDRELE-GTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEH 1730
Query: 1907 SSDLSTIQERME---ELKGQMLKFSSMAPD--LDRLNELGYRLPLNDKEIKRMQNLNRHW 1961
+ L T + + E+ Q + + + L+R + G + +R Q+L W
Sbjct: 1731 ALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVR------QRQQDLQTAW 1784
Query: 1962 SLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQK---LAVEISGNYQHLLEQQ 2018
S + T R L+ +T L +E L Q ++K L ++ + L Q
Sbjct: 1785 SELWELTQARGHALRDT----ETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQL 1840
Query: 2019 RAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
R+H+ + E+ ++ L ++ R+ + + ++ W + RR +QR
Sbjct: 1841 RSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQR 1900
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLVEV---------SYLPMSGLGSVPIPLQQARTLFD 2129
R ++ + R R+R W V S P SG P+ L + L
Sbjct: 1901 RAQLE-RARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSG----PLKLSAHQWLRA 1955
Query: 2130 EVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA------ALQAELAEIQEKWKSASM 2183
E++ +EK++ QQ + + G+Q LL+A + + ALQ + ++ + W
Sbjct: 1956 ELEAREKLW--QQATQL-----GQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQE 2008
Query: 2184 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 2243
RL+ ++++ FL +C + LE++ L A+++ K +
Sbjct: 2009 RLQAEQQEQLFL----RECGR-----LEEI-----------------LAAQEVSLKT--S 2040
Query: 2244 AVGSWTDDLTQLSLLKDTLSAYISADDI--SILNERVELLQRQWEELCHQLSLRRQQIGE 2301
A+GS +++ QL + ++A D + L ER++ L+R + L+R+ +
Sbjct: 2041 ALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100
Query: 2302 RLNE-----------WAVFSEKNKELCEWLTQMESKVSQN---GDILIEEMIEKLKKD-- 2345
L E A F++ + +W+ ++ + GD+ + ++ L K
Sbjct: 2101 ELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL--RDKLKPLLKHQA 2158
Query: 2346 YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK 2405
++ E+ +E + + GE L SH +A E+ +L + W+ L +A R ++L+
Sbjct: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHP-RAGEVSQRLQGLRKHWEDLRQAMALRGQELE 2217
Query: 2406 ETLVAVQQLDKNMSSLRTWLAHIESEL-AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 2464
+ ++ L + + W+ E ++ + D + +++R+L +E + + +
Sbjct: 2218 DRRNFLEFLQR-VDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL---REFRGNSAGDT 2273
Query: 2465 TGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRL 2524
G A + ++ ++ L + E I Q L+ RW + + + ++E +
Sbjct: 2274 VGDACIRSISDLSLQLKNR--DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEI 2331
Query: 2525 W--QKFLDDYSRFEDWLKSSERTAAFPS-SSGVIYTVAKEELKKFEAFQRQVHECLTQLE 2581
+ LD+ ++ + E+ A + G + L+K E +R+VH Q+E
Sbjct: 2332 HVLSRELDNVTK-----RIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVE 2386
Query: 2582 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641
+ ++ RL + + ++A L+ E + W L+ R R + Q ++ +
Sbjct: 2387 SLEREVGRLCQRS-PEAAHGLRHRQQEVAESWWQLRSRAQK-RREALDALHQAQKLQAML 2444
Query: 2642 DSILVWLTEMDLQL-TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
+LV + Q+ T+ S + + +++ + + E+ + I + G+QL+
Sbjct: 2445 QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTA 2504
Query: 2701 SEPLDAAI------IEEELDELRRYCQE 2722
P + I +E+EL L QE
Sbjct: 2505 GHPFSSDIRQVLAGLEQELSSLEGAWQE 2532
Score = 111 bits (278), Expect = 1e-23
Identities = 512/2767 (18%), Positives = 1034/2767 (37%), Gaps = 401/2767 (14%)
Query: 48 QAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSE- 106
Q HL + E L + + A + S+ + ++ QT+L + + ++
Sbjct: 834 QTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADT 893
Query: 107 LEAMTEKLQ-YLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAEL 165
LE M K + +LT++ + + AE+ E+LRQ +Q +++ + +L
Sbjct: 894 LEVMQLKYENFLTALAVGKGLW---AEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQL 950
Query: 166 KKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPE- 224
+ AL++ +A QL+H + S ++ P VQL L++
Sbjct: 951 E----ALKREKAV-------------QLAHSVEVCSFLQECGPT--QVQLRDVLLQLEAL 991
Query: 225 DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQ--------YEQEMKHLQQ 276
+S CHA Q++ L+ ++ + +Q+ VV+ E+ + +++ LQ
Sbjct: 992 QPGSSEDTCHALQLAQKKTLVLE----RRVHFLQSVVVKVEEPGYAESQPLQGQVETLQG 1047
Query: 277 LIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 336
L++ ++ + + Q Q+ + ++L + Q Q+ S K +++ A
Sbjct: 1048 LLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRS-----KEVSVDVASA 1102
Query: 337 TMLLT-----VTEVEGLAEGTEDLDGELLPTPSAH-------PSV--VMMTAGRCHTLLS 382
LL + E+ E + LD + P + P+ V+ G+ +L
Sbjct: 1103 QRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLW 1162
Query: 383 PVTEESGEEGTNSEISSPPACRSPSPVANTDA-----SVNQDIAYYQALSAE-----RLQ 432
++ +EG + + AN A ++ +D+ +L + RL
Sbjct: 1163 EQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLL 1222
Query: 433 TDAAKIHPSTSASQEFYEPGLEPSATA---KLGDLQRSWETLKNVISEKQRTLYEALERQ 489
+ + A E P+A +L +Q W L+ +++R L +L+ Q
Sbjct: 1223 STLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQ 1282
Query: 490 QKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ-MAEHQALMDEILMLQDEINELQSSL 548
+ QD + + ME L + P R Q + H+A E+L + + LQ +
Sbjct: 1283 EWKQD-VAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQ-V 1340
Query: 549 AEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQA 608
EL+S P Q +Q+ R+ +R K + + E+ ++ + +QEQ
Sbjct: 1341 GRELLSRR----PCGQEDIQT-------RLQGLRSKWEALNRKMTERGDELQQAGQQEQL 1389
Query: 609 LQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA-QLMDCQNMLVEIEQKVVALSEL 667
L++ + ++L+ L+ AL + D+ + Q + ++ +E E + +A
Sbjct: 1390 LRQLQDAKEQLEQ--------LEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMA 1441
Query: 668 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSL----------LELQRALHDKQLNMQGT 717
++ + + +E ++ +L L+G L +EL + H + +
Sbjct: 1442 ALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWV 1501
Query: 718 AQ----------------------EKEESDVDLTATQSPGVQEWLAQARTTWTQ---QRQ 752
A+ + +E V++ A Q VQ L+ R+ Q Q
Sbjct: 1502 AEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQ-VQRVLSSGRSLAASGHPQAQ 1560
Query: 753 SSLQQQKELEQELAEQKSLLRSVASRGEEILIQHS----AAETSGDAGEK-PDVLSQELG 807
++Q +ELE AE + + A ++ + +E G EK P V S++ G
Sbjct: 1561 HIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYG 1620
Query: 808 ME--------GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSG 859
+ + + ++++ + W S+ + T Q L + ++Q V RL
Sbjct: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVV----QERLREQ 1676
Query: 860 VPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLD 919
+ + T+D+ +L L++ E G Q +Q G S +
Sbjct: 1677 LRALQELAATRDRELEGTLR--LHEFLREAEDLQGWLASQ----KQAAKGGESLG----E 1726
Query: 920 DVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRD-VI 978
D E L + T + + + +Q + A L +++ E G + ++
Sbjct: 1727 DPEHALHLCTKFAKFQHQVEMGSQRVAAC-------------RLLAESLLERGHSAGPMV 1773
Query: 979 EDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANV 1038
L S L + R H +++ + L DL + T + + + +A
Sbjct: 1774 RQRQQDLQTAWSELWELTQARGHALRDT-ETTLRVHRDLLEVLTQVQEKATSLPNNVARD 1832
Query: 1039 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE--LSKLQDMYDELMM 1096
+ Q+ + Q E L + + EL ++Q P Q + + Q +
Sbjct: 1833 L-CGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWA 1891
Query: 1097 IIGSR---RSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDK 1153
++ R R + L +++ A++D A + ++ D ++ SS+E L
Sbjct: 1892 VLQRRMEQRRAQLERARLLARFRTAVRDYA----SWAARVRQDLQVEESSQEPSSGPLKL 1947
Query: 1154 HKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE---- 1209
Q L + + E L+ Q+ TQ + + A K + L+
Sbjct: 1948 SAH--QWLRAELEAREKLW--------QQATQLGQQALLAAGTPTKEVQEELRALQDQRD 1997
Query: 1210 YILETWSHLDE----DQQE---------LSRQLEVVESSIPS--VGLVEENEDRLIDRIT 1254
+ +TW+ E +QQE L L E S+ + +G E ++LI +
Sbjct: 1998 QVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHE 2057
Query: 1255 LYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRL 1314
++ + ++ ++ + L + L +R + L + ++ E S + + L
Sbjct: 2058 VFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASL--- 2114
Query: 1315 ETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLE---FSK 1371
++ +T+ +++ D W+Q+ W QQ + P +RD L L+ F
Sbjct: 2115 --LMASFTQAATQAED---WIQA-------WAQQ-LKEPVPPGDLRDKLKPLLKHQAFEA 2161
Query: 1372 EVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQM 1431
EV A + +SV G LL + L + W DL + L+
Sbjct: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDL--------RQAMALRG 2213
Query: 1432 DKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--------IHEYLQKYKGFKID 1483
+L R E + + L E IQ+ E +K ++G + L++++G
Sbjct: 2214 QELEDRRNFLEFLQRVDLAEAWIQEKE--VKMNVGDLGQDLEHCLQLRRRLREFRGNSAG 2271
Query: 1484 INCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEG 1543
+ ++ LQ+ ++D E + ++ +N W G + Q LEG
Sbjct: 2272 DTVGDACIRSISDLSLQLKNRDPEEVKI----ICQRRSQLNNRWASFHGNLLRYQQQLEG 2327
Query: 1544 LLESWSEYENNVQCLKTWFETQEKRLKQQHRI-------GDQASVQNALKDCQDLEDLIK 1596
LE + L + KR++++ + D SVQ L+ ++LE +
Sbjct: 2328 ALE--------IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVH 2379
Query: 1597 AKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 1656
+ +VE +E+ L Q E + +E+ ++W L + + L ++
Sbjct: 2380 PIQAQVESLEREVGRLCQRSPEAAHGL-RHRQQEVAESWWQLRSRAQKRREALDAL---- 2434
Query: 1657 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQD------DLEKQERS 1710
H+ K+ + L E S R R + A + V+ + L++ +L+ S
Sbjct: 2435 --HQA--QKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
Query: 1711 LQKFGSITNQLLKECHP------PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKAL-LQ 1763
+ S QLL HP V L L + W QLQ +AL LQ
Sbjct: 2491 ISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE------HQLQLQQALELQ 2544
Query: 1764 LWQRYKDYSKQCASTVQQQE----DRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGT 1819
L+ S+V++ E + + L +A E W L L
Sbjct: 2545 LF----------LSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM--LEWDLEV 2592
Query: 1820 VKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA-----LCKQQTSLQAG 1874
+ L L Q A SA+ Q L + QA ++ LQA
Sbjct: 2593 QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAF 2652
Query: 1875 VLDYETFA-----KSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSS 1929
+ D + A K+L ALE +++ + + L Q EL M +
Sbjct: 2653 LQDSQEVAAWLREKNLVALEEGLLDTAML--------PAQLQKQQNFQAELDASMHQQQE 2704
Query: 1930 MAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSF--LLQHQTFLE 1987
+ + RL + G+ P ++ +R++ L W + + ++ +KLQ L+ + +E
Sbjct: 2705 LQREGQRLLQGGH--PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSME 2762
Query: 1988 KCETWMEFL-VQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL 2046
+ E W+E + V+ + LL QR +A + + + +++ Q +
Sbjct: 2763 ELENWLEPIEVELRAPTVGQALPGVGELLGTQRE---LEAAVDKKARQAEALLGQAQAFV 2819
Query: 2047 EQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 2106
+G +D LL +++ + Q+RR ++++ + +R+ E++ W+ E
Sbjct: 2820 REGHCLAQDVEEQARRLL-QRFKSLREPLQERRTALEARSLLLKFFRDADEEM-AWVQE- 2876
Query: 2107 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 2166
LP++ L R L ++ Q E + + + G +L+ + A
Sbjct: 2877 -KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEV 2935
Query: 2167 LQAELAEIQEKWKS-ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK----LS 2221
A +Q+ K+ A +R E +++L LL+ ++ ++ + + LE ++ S
Sbjct: 2936 ----AARVQQLEKAMAHLRAEAARRRL--LLQQAQEAQQFLTELLEAGSWLAERGHVLDS 2989
Query: 2222 QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELL 2281
+ + E A R + + + +++ + +L L + + + +L +++ +
Sbjct: 2990 EDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVL-AQLQAV 3048
Query: 2282 QRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ-------NGDIL 2334
+ EL + R + E+L + + L WLT + G +
Sbjct: 3049 REAHAELLRRAEARGHGLQEQL-QLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
Query: 2335 IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLL 2394
+EE + +K+ Q ++ Q L+++ L + + + I+ + ++ W+ L
Sbjct: 3108 LEEKFDAFRKEVQ---SLGQAKVYALRKLAGTLERGA-PRRYPHIQAQRSRIEAAWERLD 3163
Query: 2395 DLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQ- 2453
I AR E L A ++ + ++ + A D +S R L +Q
Sbjct: 3164 QAIKART----ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQH 3219
Query: 2454 QELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSME 2513
+ L+R++E VA + +AC + + W + A + E
Sbjct: 3220 RRLERELEAMEKEVARL---------QTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQE 3270
Query: 2514 RRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV 2573
R WL + + AF + A+E ++ A ++
Sbjct: 3271 R---------------------GQWLAQAAQGHAFLGRCQELLAWAQE--RQELASSEEL 3307
Query: 2574 HECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQ 2633
E + E + Q+ L +E R + + + EG Q DN + L+ G+
Sbjct: 3308 AEDVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGR 3366
Query: 2634 REEFETA 2640
+E E A
Sbjct: 3367 LQELEEA 3373
Score = 99.8 bits (247), Expect = 4e-20
Identities = 274/1412 (19%), Positives = 535/1412 (37%), Gaps = 181/1412 (12%)
Query: 1474 LQKYKGFKIDINCKQ-LTVDFVNQSVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQ 1531
LQK+K + +++ Q + VD V + +D+ ++R + D E+ A+ WQ+LQ
Sbjct: 643 LQKHKALEAEVHRHQAVCVDLVRRG------RDLSARRPPTQPDPGERAEAVQGGWQLLQ 696
Query: 1532 GLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDL 1591
V + L+ L + + + +W + L++ DQA+ + L+ L
Sbjct: 697 TRVVGRGARLQTALLVLQYFADAAEAA-SWLRERRSSLERASCGQDQAAAETLLRRHVRL 755
Query: 1592 EDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMS----TLRELGQTWANLDHMVGQ--- 1644
E +++A E+ ++E+ G A + +S +LR G W+ G
Sbjct: 756 ERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGP-WSEASCHPGPGDA 814
Query: 1645 LKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV---DNLQNLQ 1701
K+ L + D + + + +L LE + LQ
Sbjct: 815 WKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQ 874
Query: 1702 DDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQ----LQS 1757
LEKQ LQ+ + +TL+ + +++ N L +A +
Sbjct: 875 LWLEKQTVLLQR----------------VQPQADTLEVMQLKYENFLTALAVGKGLWAEV 918
Query: 1758 SKALLQLWQRYKDYSKQCASTVQQQEDRTNEL--LKAATNKDIADD-EVATWIQDCN--- 1811
S + QL QRY S Q ++ R +L LK +A EV +++Q+C
Sbjct: 919 SSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQ 978
Query: 1812 ----DLLKGL-----GTVKDSLFFLHELGEQ---------------LKQQVDASAASAIQ 1847
D+L L G+ +D+ L ++ +K + A S
Sbjct: 979 VQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPL 1038
Query: 1848 SDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS-- 1905
Q+ Q L Q Q+ QA ++F + + L W + L+ ++ S
Sbjct: 1039 QGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVD 1098
Query: 1906 ----------HSSDLSTI---QERMEELKGQMLKFSSM-APDLDRLNELGYRLPLNDKEI 1951
H L I QER+++L Q +++ PD + L +E+
Sbjct: 1099 VASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQEL 1158
Query: 1952 KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKC---ETWMEFLVQTEQKLAVEIS 2008
K + + W + +LQ F + F C + W+ L + + +S
Sbjct: 1159 KVLWEQRQQW-------LQEGLELQKFGREVDGFTATCANHQAWLH-LDNLGEDVREALS 1210
Query: 2009 GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQW 2068
LL+Q R + + R + L + G++L+ Q Q +L + QW
Sbjct: 1211 -----LLQQHREFGRLLSTLGPRAEALRA---HGEKLV-QSQHPAAHTVREQLQSIQAQW 1261
Query: 2069 QGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLF 2128
+ R++QRR + + + Q Q +++ +L +W+ E GL + P R +
Sbjct: 1262 TRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWMEE------KGLMAAHEPSGARRNIL 1314
Query: 2129 DEV---QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRL 2185
+ + E L + + G++LL G E +Q L ++ KW++ + ++
Sbjct: 1315 QTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED-IQTRLQGLRSKWEALNRKM 1373
Query: 2186 EE---------QKKKLAFLLKDWEKCEKGIADSLEKLRTFKK-KLSQSLPDHHEELHAEQ 2235
E Q+++L L+D ++ + + +L+ T + + SQ L H++L +E
Sbjct: 1374 TERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESES 1433
Query: 2236 MRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLR 2295
A+ S + + + ++ R+ELLQ L++R
Sbjct: 1434 RTLAAKMAALASMAHGMAASPAILEETQKHL---------RRLELLQ-------GHLAIR 1477
Query: 2296 RQQIGERLNEWAVFSEKNKELCEWLTQ---MESKVSQNGDILIEEMIEKLKKDYQEEIAI 2352
Q+ + N EL W+ + S S + + + + K+ Q E+
Sbjct: 1478 GLQLQASVELHQFCHLSNMEL-SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKA 1536
Query: 2353 AQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ 2412
Q ++ G LA + H +A I + ++ W L AR + L++ V Q
Sbjct: 1537 HQGQVQRVLSSGRSLAASGH-PQAQHIVEQCQELEGHWAELERACEARAQCLQQA-VTFQ 1594
Query: 2413 QLDKNMSSLRTWLAHIESELAKPIVYD---SCNSEEIQRKLNEQQELQRDIEKHSTGVAS 2469
Q ++S L W+ E +P+V + R +N+ Q LQ ++ + + +
Sbjct: 1595 QYFLDVSELEGWV-----EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEE 1649
Query: 2470 VLNLCEVLLHDCDACATDAECDSIQQATR-NLDRRWRNICAMSMERRLKIEETWRLWQKF 2528
+ + L T E Q+ + L + R + ++ R ++E T RL +F
Sbjct: 1650 LDQTAQTL--------TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRL-HEF 1700
Query: 2529 LDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYR 2588
L + + WL S ++ A S G A KF FQ QV ++
Sbjct: 1701 LREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAAC----- 1755
Query: 2589 RLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWL 2648
RL E+ + S MV + Q + + + H + E +L L
Sbjct: 1756 RLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVL 1815
Query: 2649 TEMDLQLTNIEH---FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 2705
T++ + T++ + C ++A+++ + ++E+ ++++++ ++ +
Sbjct: 1816 TQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQ 1875
Query: 2706 AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 2765
A +++ + + + R+E+ +L R L L+ + D A+ +
Sbjct: 1876 AHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARL------LARFRTAVRDYASWAARVRQ 1929
Query: 2766 DRSADSLLSPQPSSNLSLSLAQPLRSERSGRD 2797
D + S L LS Q LR+E R+
Sbjct: 1930 DLQVEESSQEPSSGPLKLSAHQWLRAELEARE 1961
Score = 92.4 bits (228), Expect = 7e-18
Identities = 505/2609 (19%), Positives = 976/2609 (37%), Gaps = 349/2609 (13%)
Query: 3 LDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLEL 62
L + V K E +PL ++ L L +Q Q R + + + E +L
Sbjct: 1020 LQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQL 1079
Query: 63 ILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYC 122
+L W E + + + HQ LLEE L+ + + Q + ++ C
Sbjct: 1080 LL-WAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDC 1138
Query: 123 --TEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180
++++ + LG++ +EL+ + + R Q LQ+ +++KF E+ A QA L
Sbjct: 1139 PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGL-ELQKFGREVDGFTATCANHQAWLH 1197
Query: 181 SPEVGR-----LSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA 235
+G LSL +Q LLS +L P+ +A++ L V + P H
Sbjct: 1198 LDNLGEDVREALSLLQQHREFGRLLS---TLGPRAEALRAHGEKL-----VQSQHPAAHT 1249
Query: 236 ALR----LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE-----------G 280
+Q + +RLQ + Q+ + A++ Q ++++Q++ L Q +E G
Sbjct: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWMEEKGLMAAHEPSG 1308
Query: 281 AHREI----------EDKPVATSNIQELQAQISRH---------EELAQKIKGYQEQIAS 321
A R I E + +AT E Q+ R E++ +++G + + +
Sbjct: 1309 ARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEA 1368
Query: 322 LNSKCKMLTMKAKHATML-LTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL 380
LN K + + A + +++ E E L+G L + + + H
Sbjct: 1369 LNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQ 1428
Query: 381 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 440
L + + + SP+ + T + + E LQ A
Sbjct: 1429 LESESRTLAAKMAALASMAHGMAASPAILEETQKHLRR---------LELLQGHLAIRGL 1479
Query: 441 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 500
AS E ++ L +++ SW +++ + E L Q + +
Sbjct: 1480 QLQASVELHQ-------FCHLSNMELSW-VAEHMPHGSPTSYTECLNGAQSLHRKHKELQ 1531
Query: 501 TKMEAIELKLSESPEPGRSPESQ---MAEHQALMDEILMLQDEINELQSSLAEELVSESC 557
+++A + ++ GRS + A+H + ++ EL+ AE + +C
Sbjct: 1532 VEVKAHQGQVQRVLSSGRSLAASGHPQAQH---------IVEQCQELEGHWAE--LERAC 1580
Query: 558 EADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEAD 617
EA A+ L T +S + KR L+ + + +E + + +++ +
Sbjct: 1581 EAR-AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGR-DEAATLRLINKHQALQE 1638
Query: 618 ELDSWLLSTKATLDTA--LSPPKEPMDMEAQLMDCQNMLVE-IEQKVVALSELSVHNENL 674
EL + S + TA L+ P+ P + Q ++ E + +++ AL EL+ +
Sbjct: 1639 ELAIYWSSMEELDQTAQTLTGPEVP--------EQQRVVQERLREQLRALQELAATRDRE 1690
Query: 675 LLEGKAHTKD---EAEQLAGKLRRLKGSL-----------------LELQRALHDKQLNM 714
L EG + EAE L G L K + + + H ++
Sbjct: 1691 L-EGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749
Query: 715 QGTAQEK--EESDVDLTATQSPGVQEWLAQARTTW------TQQRQSSLQQQKELEQELA 766
Q A + ES ++ + P V++ +T W TQ R +L ++ E L
Sbjct: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHAL---RDTETTLR 1806
Query: 767 EQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQEL-GMEGEKSSAEDQMRMKWES 825
+ LL E+L Q TS P+ ++++L G+E + S +
Sbjct: 1807 VHRDLL--------EVLTQVQEKATS-----LPNNVARDLCGLEAQLRSHQ--------G 1845
Query: 826 LHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQA 885
L +E ++ LQ +LE R +L G + Q + AVT L +
Sbjct: 1846 LERELVGTERQLQELLETA------GRVQKLCPGPQAH---AVQQRQQAVTQAWAVLQRR 1896
Query: 886 FEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEI 945
E+ +Q A+ L + V ++W V + L V EE+ + +
Sbjct: 1897 MEQRRAQLERAR-----LLARFRTAVRDYASWAARVRQDLQV------EESSQEPSSGPL 1945
Query: 946 LAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKE 1005
+ + E++ + L+ QA LG+ +LL + + +++E
Sbjct: 1946 KLSAHQWLRAELEAREKLWQQATQ----------------LGQQALLAAGTPTK--EVQE 1987
Query: 1006 RLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGII 1065
L+ +L D + + Q A E+ AEQ E + E G E
Sbjct: 1988 ELR--------------ALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQ 2033
Query: 1066 ELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNL-TLKSQYER-----AL 1119
E+ + L +++L + +++ +++ + + L + L TL+ R L
Sbjct: 2034 EVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILL 2093
Query: 1120 QDLADLLETGQEK---------MAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTET 1170
Q + E + + MA + +++ IQ + KE + L
Sbjct: 2094 QRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL 2153
Query: 1171 LFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVE----LEYILETWSHLDEDQQELS 1226
L + VQ + T + + A+L ++H R E L+ + + W L +
Sbjct: 2154 LKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRG 2213
Query: 1227 RQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL------ 1280
++LE + + + V+ E + ++ +K ++ + L L +RL
Sbjct: 2214 QELEDRRNFLEFLQRVDLAEAWIQEK-----EVKMNVGDLGQDLEHCLQLRRRLREFRGN 2268
Query: 1281 ----LISISC----SDLESQL-NQLGECWLSNTNKMSKELHRLETILKHWTRYQS--ESA 1329
+ +C SDL QL N+ E + S+ +R + + RYQ E A
Sbjct: 2269 SAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGA 2328
Query: 1330 DLIHWLQSAKDRLEFWTQ------QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV 1383
IH L D + Q Q++ ++LE V+ L E +EV + S+
Sbjct: 2329 LEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388
Query: 1384 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEV 1443
+L + LR + W L + +E L D L + +
Sbjct: 2389 EREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREAL-----DALHQAQKLQAM 2443
Query: 1444 MSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISS 1503
+ + + ++ D L++++ K +++ ++ + Q+
Sbjct: 2444 LQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL-- 2501
Query: 1504 QDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFE 1563
+ + +D + L + + L+G E L+ LE + ++V+ ++ W
Sbjct: 2502 --LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL-QLFLSSVEKMERWLC 2558
Query: 1564 TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI 1623
++E L + A ++ L + LE ++ + ++ +E L Q + S
Sbjct: 2559 SKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSA 2618
Query: 1624 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL 1683
+ L + A L G + L+ L Q + ++ ++L E LL
Sbjct: 2619 LGRCQAMLLRKEA-LFRQAGTRRHRLEE-LRQLQAFLQDSQEVAAWLREKNLVALEEGLL 2676
Query: 1684 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 1743
++ Q+Q QN Q +L+ Q+ +LL+ HP +E + L+E+
Sbjct: 2677 DTAMLPAQLQKQ--QNFQAELDASMHQQQELQREGQRLLQGGHP-ASEAIQERLEELGAL 2733
Query: 1744 WNNL----------LEEIAEQLQSSKALLQLWQRYKDYSKQC-ASTVQQQEDRTNELLKA 1792
W L L++ E L+ +++ +L + + A TV Q ELL
Sbjct: 2734 WGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGT 2793
Query: 1793 ATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLS 1852
+ A D+ A + + + F+ E G L Q V+ A
Sbjct: 2794 QRELEAAVDKKARQAE---------ALLGQAQAFVRE-GHCLAQDVEEQARR-------- 2835
Query: 1853 LSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHS-SDLS 1911
L Q +L + L +++T+L+A L + F + E + AW+ E + QD S S +
Sbjct: 2836 LLQRFKSLREPLQERRTALEARSLLLKFFRDADEEM-AWVQEKLPLAAAQDYGQSLSAVR 2894
Query: 1912 TIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-----LNDKEIKRMQNLNRHWSLISS 1966
+QE+ + L+ +M ++ + GY+L + R+Q L + + + +
Sbjct: 2895 HLQEQHQNLESEMSSHEALTRVV---LGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRA 2951
Query: 1967 QTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY----QHLLEQ----Q 2018
+ R LQ + Q FL + +L + L E G+ Q LL + +
Sbjct: 2952 EAARRRLLLQQ-AQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATK 3010
Query: 2019 RAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 2078
R E F + QQ LLE + + + +L + ++RRA+ R
Sbjct: 3011 RDLEAFSPRIERLQQTA--------ALLESRKNPESPKVLAQLQAVREAHAELLRRAEAR 3062
Query: 2079 RGIIDSQIRQWQRYREMAEKLRKWLV-EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV 2137
+ Q++ Q RE L WL + + G ++ FD + KE
Sbjct: 3063 GHGLQEQLQLHQLERETL-LLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR-KEVQ 3120
Query: 2138 FLRQQGSYILTVEAGKQLLLSADSGAEAA---LQAELAEIQEKWKSASMRLEEQKKKLAF 2194
L Q Y L AG + + GA +QA+ + I+ W+ ++ + + LA
Sbjct: 3121 SLGQAKVYALRKLAG-----TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLA- 3174
Query: 2195 LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE--ELHAEQMRCKELENAVGSWTDDL 2252
+ ++ A+ +++ K L + H + Q + + LE + + ++
Sbjct: 3175 AAHEVHSFQQAAAELQGRMQE-KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEV 3233
Query: 2253 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 2312
+L L A + +Q W L + R Q + + A F +
Sbjct: 3234 ARLQTEACRLGQLHPAAPGGLAK-----VQEAWATLQAKAQERGQWLAQAAQGHA-FLGR 3287
Query: 2313 NKELCEWLTQMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK 2369
+EL W + + S D+ E + ++ +EI + L+Q G++L
Sbjct: 3288 CQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVD 3347
Query: 2370 ASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE 2429
SH A E+ L ++ R Q L + A R ++ E+ +Q+L + + WLA E
Sbjct: 3348 NSHFMSA-EVTECLQELEGRLQELEEAWALRWQRCAESW-GLQKLRQRLEQAEAWLACWE 3405
Query: 2430 SELAKPIVYDSCNSEEIQRKLNEQQELQR 2458
L KP S + +++ L+ Q+L++
Sbjct: 3406 GLLLKPDYGHSVS--DVELLLHRHQDLEK 3432
Score = 87.0 bits (214), Expect = 3e-16
Identities = 319/1603 (19%), Positives = 627/1603 (39%), Gaps = 184/1603 (11%)
Query: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680
S+ + EL Q W L+ + + + L +H V ++ S+L E + +
Sbjct: 933 STQIQRQQEELSQRWGQLEALKREKAVQL--------AHSV---EVCSFLQECGPTQVQL 981
Query: 1681 RLLTGSLEAVQV--QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 1738
R + LEA+Q D LQ +K ++ + + ++K P E+ L+
Sbjct: 982 RDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAES--QPLQ 1039
Query: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 1798
LL+++ EQ+ QR + ++ A QE + L + +
Sbjct: 1040 GQVETLQGLLKQVQEQVA---------QRARRQAETQARQSFLQESQQLLLWAESVQAQL 1090
Query: 1799 ADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQ------VDASAASAIQSDQLS 1852
EV+ + LL+ + + + E +QL Q +D + + +
Sbjct: 1091 RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRV 1150
Query: 1853 LSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQ----GQDPSHSS 1908
L Q L+ ++Q LQ G L+ + F + ++ A + L G+D +
Sbjct: 1151 LGQQGQELKVLWEQRQQWLQEG-LELQKFGREVDGFTATCANHQAWLHLDNLGEDVREA- 1208
Query: 1909 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-----PLNDKEIKRMQNLNRHWSL 1963
LS +Q+ E G++L S++ P + L G +L P +++Q++ W+
Sbjct: 1209 -LSLLQQHREF--GRLL--STLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTR 1263
Query: 1964 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 2023
+ ++ +R +L + L Q Q + + M+++ + A E SG +++L+ + HE
Sbjct: 1264 LQGRSEQRRRQLLASL-QLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEA 1322
Query: 2024 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 2083
++E+ + ++ + ++ G+ LL + D +L L ++W+ + R+ +R +
Sbjct: 1323 AESELLATRRHVEALQQVGRELLSRRPCGQED-IQTRLQGLRSKWEALNRKMTERGDELQ 1381
Query: 2084 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 2143
+Q Q R++ + + L S G Q+ + +++ + +
Sbjct: 1382 QAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTL----- 1436
Query: 2144 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFL---LKDWE 2200
A K L++ + AA A L E Q+ + RLE + LA L+
Sbjct: 1437 -------AAKMAALASMAHGMAASPAILEETQKHLR----RLELLQGHLAIRGLQLQASV 1485
Query: 2201 KCEKGIADSLEKLRTFKKKLSQSLPDHHEE-LHAEQM---RCKELENAVGSWTDDLTQLS 2256
+ + S +L + + P + E L+ Q + KEL+ V + + ++
Sbjct: 1486 ELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL 1545
Query: 2257 LLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKEL 2316
+L+A I+ E+ + L+ W EL R Q + + + F + + EL
Sbjct: 1546 SSGRSLAASGHPQAQHIV-EQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVS-EL 1603
Query: 2317 CEWLTQMESKVSQNGDILIEEMIEKLKKDYQ---EEIAIAQENKIQLQQMGERLAKASHE 2373
W+ + VS E +L +Q EE+AI + +L Q + L
Sbjct: 1604 EGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVP 1663
Query: 2374 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 2433
+ ++ +L ++ + L +L A R ++L+ TL + + + L+ WLA + + A
Sbjct: 1664 EQQRVVQERL---REQLRALQELAATRDRELEGTL-RLHEFLREAEDLQGWLAS-QKQAA 1718
Query: 2434 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 2493
K + E + + Q +E S VA+ L E LL + +
Sbjct: 1719 KGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGP-----MV 1773
Query: 2494 QQATRNLDRRWRNICAMSMERRLKI---EETWRLWQKFLDDYSRFEDWLKSSERTAAFPS 2550
+Q ++L W + ++ R + E T R+ + L+ ++ + E+ + P+
Sbjct: 1774 RQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQ------EKATSLPN 1827
Query: 2551 SSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 2610
+ + +L+ + +R++ QL+ + + R+ + A +++Q
Sbjct: 1828 NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVT 1887
Query: 2611 QRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKI 2670
Q W LQ+R+ +L+ F TA W + L +E S+ +
Sbjct: 1888 QAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWAARVRQDL-QVEESSQEPSSGPL 1945
Query: 2671 KQLKAFQ---QEISLNHNKIEQIIAQGEQ-LIEKSEPLDAAIIEEELDELRRYCQEVFGR 2726
K L A Q E+ +Q G+Q L+ P ++EEL L+ +V+
Sbjct: 1946 K-LSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE--VQEELRALQDQRDQVY-- 2000
Query: 2727 VERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLA 2786
+ + +K RL E +L L + L ++ L+ Q S + +L
Sbjct: 2001 -QTWARKQERLQAEQQE------QLFLRECGRLEEI----------LAAQEVSLKTSALG 2043
Query: 2787 QPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAV 2846
+SV+ + L R E + + L ++D++ ++
Sbjct: 2044 -------------SSVEEVE-------QLIRKHEVFL-KVLTAQDKKEAALRERLKTLRR 2082
Query: 2847 GLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 2906
D + Q R K L +SR ++ S T + + + + + L E
Sbjct: 2083 PRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVP 2142
Query: 2907 SIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKW 2966
D +L+ LK + + V H E V + E L AQ+ + + Q LQ
Sbjct: 2143 PGDLRDKLKPLLKHQ--AFEAEVQAH--EEVMTSVAKKGEALLAQSHPRAGEVSQRLQGL 2198
Query: 2967 QQFNSDLNSIWAWLGDTEEE----LEQLQRLELST---DIQTIELQIKKL-KELQKAVDH 3018
++ DL A G E+ LE LQR++L+ + +++ + L ++L+ +
Sbjct: 2199 RKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQL 2258
Query: 3019 RK----------------AIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLL 3062
R+ A I SI+ S + D +E + + R SQ+N RW L
Sbjct: 2259 RRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNL 2318
Query: 3063 EEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQI 3122
++ L+ AL H +S L + + I ++ I +D D E +Q +L++
Sbjct: 2319 LRYQQQLEGAL----EIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQ----RLLR- 2369
Query: 3123 KHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNR 3165
KHE LE ++ Q S + V G C + E H + +R
Sbjct: 2370 KHEELEREVHPIQAQVESLEREV---GRLCQRSPEAAHGLRHR 2409
Score = 57.8 bits (138), Expect = 2e-07
Identities = 145/723 (20%), Positives = 273/723 (37%), Gaps = 112/723 (15%)
Query: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
EL+AAV K Q L + + L Q QA L + L+E LE
Sbjct: 2796 ELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALE 2855
Query: 62 ---LILK----------WIEKAKVLAHGTIAWNSASQLREQYILHQTLLEE--SKEIDSE 106
L+LK W+++ LA S S +R HQ L E S E +
Sbjct: 2856 ARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915
Query: 107 LEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELK 166
+ T + +++ +V +L + LR R LQ A ++ ++F EL
Sbjct: 2916 VVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQA-QEAQQFLTELL 2974
Query: 167 KLQAALEQAQATLTSPEVGRLSLKEQ--LSHRQHLLSEMESLKPKVQAVQLCQSAL---R 221
+ + L + L S ++G + Q L + ++E+ P+++ +Q + L +
Sbjct: 2975 EAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRK 3034
Query: 222 IPED--VVASLPL---CHAALRLQEEA------SRLQHTAIQQCNIM-------QAAVVQ 263
PE V+A L HA L + EA +LQ +++ ++ +AA +
Sbjct: 3035 NPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAE 3094
Query: 264 YEQYEQEM---KHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELA-QKIKGYQEQI 319
+ Y Q++ K L++ + +E++ + + + L+ E A ++ Q Q
Sbjct: 3095 SQDYGQDLEGVKVLEEKFDAFRKEVQS--LGQAKVYALRKLAGTLERGAPRRYPHIQAQR 3152
Query: 320 ASLNSKCKMLTMKAKHATMLLTVT-EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 378
+ + + + L K T L EV + +L G + + +M H
Sbjct: 3153 SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM-----QEKTALMKGEDGGH 3207
Query: 379 TLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 438
+L S T + E+ + + +++A RLQT+A ++
Sbjct: 3208 SLSSVRTLQQQHRRLERELEA----------------MEKEVA--------RLQTEACRL 3243
Query: 439 HPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS 498
L P+A L +Q +W TL+ E+ + L +A + +
Sbjct: 3244 GQ------------LHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL 3291
Query: 499 ISTKMEAIELKLSES-PEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESC 557
++ E EL SE E E + +H+ L EI + + +L+ ++LV S
Sbjct: 3292 LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQE-GQQLVDNS- 3349
Query: 558 EADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEAD 617
++ ++ + G+ Q LEE + + + LQ+ R +
Sbjct: 3350 --------------HFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLE 3395
Query: 618 ELDSWLLSTKATLDTALSPPKEPMDMEAQLM-----DCQNMLVEIEQKVVALSELSVHNE 672
+ ++WL + L L P + +L+ D + +L E+K + + + E
Sbjct: 3396 QAEAWLACWEGLL---LKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQE 3452
Query: 673 NLL 675
LL
Sbjct: 3453 LLL 3455
Score = 51.2 bits (121), Expect = 2e-05
Identities = 236/1229 (19%), Positives = 446/1229 (36%), Gaps = 218/1229 (17%)
Query: 2059 LKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR-KWLVEVSYLPMSGLGSV 2117
L L LS W G+ R + ++ Q QR +A + + K + S+L
Sbjct: 356 LGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFL-------- 407
Query: 2118 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA---EAALQA--ELA 2172
+ A + D+ R + + TVEA Q L ++G E QA E+A
Sbjct: 408 ----KDAEQVLDQA--------RAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIA 455
Query: 2173 EI--QEK---WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDH 2227
+I QE+ W + R EE + LL+ + K +AD L ++ + S
Sbjct: 456 DILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAAS---- 511
Query: 2228 HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISI-------------L 2274
H+ E+++ A G ++ +L D L A +SA + L
Sbjct: 512 HQ---LEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSL 568
Query: 2275 NERVELLQRQWEELCH-QLSL-----RRQQIGERLNEWAVFSEKNKELCEWLTQMESKVS 2328
VE+LQ + L Q SL R+ + E+ + A F +E WL + +V
Sbjct: 569 GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRV- 627
Query: 2329 QNGDILIEEMIEKLKKDYQEEIAIAQENK------IQLQQMGERLAKASHESKASEIEYK 2382
G+ + + ++ Q+ A+ E + L + G L+ ++ E +
Sbjct: 628 --GNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGE-R 684
Query: 2383 LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCN 2442
V WQ L + R +L+ L+ +Q + + +WL S L + SC
Sbjct: 685 AEAVQGGWQLLQTRVVGRGARLQTALLVLQYF-ADAAEAASWLRERRSSLERA----SCG 739
Query: 2443 SEE------------IQRKLNEQQELQRDIEKHSTGVASVLNL----------------- 2473
++ ++R L R +E+ ++ +L
Sbjct: 740 QDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNP 799
Query: 2474 -------CEVLLHDCDACATDAECD------SIQQATRNLDRRWRNICAMSMERRLKIEE 2520
C D A AE D +I Q +L + + ++ A++ RR ++EE
Sbjct: 800 GPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEE 859
Query: 2521 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
L+ F + WL+ V+ + + E Q + LT L
Sbjct: 860 AMALFG-FCSSCGELQLWLEKQT----------VLLQRVQPQADTLEVMQLKYENFLTAL 908
Query: 2581 ELINKQYRRLA------RENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 2634
+ + ++ R+ ++ +++ E +QRW L+ +L H + +
Sbjct: 909 AVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSV-EV 967
Query: 2635 EEFETARDSILVWLTEMDLQLTNIEHFSECD----VQAKIKQLKAFQQEISLNHNKIEQI 2690
F V L ++ LQL ++ S D +Q K+ ++ + + + ++
Sbjct: 968 CSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKV 1027
Query: 2691 IAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRE 2750
G +S+PL + E L L + QE + R + + R+
Sbjct: 1028 EEPG---YAESQPLQGQV--ETLQGLLKQVQEQVAQRARR------------QAETQARQ 1070
Query: 2751 LELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWD 2810
L++S L L W A+S+ + S +S+ +A R R +D ++ I L +
Sbjct: 1071 SFLQESQQL--LLW----AESVQAQLRSKEVSVDVASAQRLLREHQDL---LEEIHLWQE 1121
Query: 2811 HDYDLSRDLESAMSRALPSEDEE---------GQDDKDFYLRGAVGLSGDHSALESQIRQ 2861
L D +S AL D + GQ ++ + LE Q +
Sbjct: 1122 RLQQL--DAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQ--K 1177
Query: 2862 LGKALDD-----SRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEH 2916
G+ +D + Q + + L ++ + +LL ++++
Sbjct: 1178 FGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGE 1237
Query: 2917 KLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSI 2976
KL + + H+ Q + +W LQ ++ + ++ +LQ Q++ D+ +
Sbjct: 1238 KLVQSQHPAA-----HTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL-QEWKQDVAEL 1291
Query: 2977 WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA 3036
W+ EE + E S + I +K+ + + + + + ++ E
Sbjct: 1292 MQWM----EEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSR 1347
Query: 3037 DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRR 3096
D+Q RL + +W+ + + E LQ A Q Q +L +
Sbjct: 1348 RPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQ-----------LLRQLQDA 1396
Query: 3097 KNEIVPIDSNL-DAEILQD-HHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE 3154
K ++ ++ L +E QD Q +Q +H+ LES+ R +L L A G
Sbjct: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR--TLAAKMAALASMAHGMAASP 1454
Query: 3155 AKEKVHVIGNRLKLLLKEVSRHIKELEKL 3183
A +L+E +H++ LE L
Sbjct: 1455 A-------------ILEETQKHLRRLELL 1470
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 128 bits (321), Expect = 1e-28
Identities = 381/2118 (17%), Positives = 860/2118 (40%), Gaps = 312/2118 (14%)
Query: 437 KIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSL 496
++ P + P + + G ++ ETL+ + ++ L E Q +++
Sbjct: 250 QLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC 309
Query: 497 QSISTKMEAIELKLSES-PEPGRSPESQMAEHQALMDEILMLQDEINELQSS----LAE- 550
++++ EA++ +L E E + + MAE L+ ++ ++ I +L+ +AE
Sbjct: 310 TLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAET 369
Query: 551 -ELVSESCEADPAEQLALQSTLTVLAERMSTIR-MKASGKRQLLEEKLNDQLEEQRQEQA 608
+ E+ E E L+S + + + +R K +R EE Q+ E+A
Sbjct: 370 KRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEA 429
Query: 609 LQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELS 668
++ + E DE + T E + + Q L ++Q+VV + + S
Sbjct: 430 RRKLKAEMDEQIKTIEKTS----------------EEERISLQQELSRVKQEVVDVMKKS 473
Query: 669 VHNENLLLEGKAHTKDEA---EQLAGKLRRLKGSLLE-LQRALHDKQLNMQGTAQEKEES 724
+ L+ K H K+ A ++L KL+ + E ++ AL Q +QEKE+
Sbjct: 474 SEEQIAKLQ-KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQ 532
Query: 725 DVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE------LEQELAEQKSLLRSVASR 778
+ A + +Q+ +A T ++ + LQQ+ E LE E + +KSL + ++
Sbjct: 533 --ESLALEELELQK---KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQEN-KNQ 586
Query: 779 GEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQ 838
+++ + A + + V + +E K + K + L Q++ T+ + L+
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646
Query: 839 NVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 898
EQE+E +L + ++ + + + T +K LD E +SS+ +
Sbjct: 647 EKCEQEKETLL--KDKEIIFQAHIEEMNEKTLEK------LDVKQTELESLSSELSEVLK 698
Query: 899 QSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMD 958
LE++L ++L ++T+ K +E+ +MD
Sbjct: 699 ARHKLEEEL----------------------SVLKDQTD----------KMKQELEAKMD 726
Query: 959 KNKNLFSQAFPENGDNRDV-IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDL 1017
+ KN Q +V I+ T L +++ L+ ++ +R +KE + N + D+
Sbjct: 727 EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADI 786
Query: 1018 KVLFTSL--ADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 1075
K L A K + Q + + E + Q + L + + I L ++ +++
Sbjct: 787 KRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVE 846
Query: 1076 VEQPSM-QELSKLQDMYDELMMIIGSRRSGLNQNL-TLKSQYERALQDLADLLETGQEKM 1133
++ + EL + +LM + + S + Q + +L YE L+D G ++
Sbjct: 847 AQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED-------GNKEQ 899
Query: 1134 AGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 1193
++I+V + I Q+ + K+ + ILT+ L K S + E ++ T+ Q
Sbjct: 900 EQTKQILVEKENMILQMREGQKKEIE------ILTQKLSAKEDSIHILNE-EYETKFKNQ 952
Query: 1194 ASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRI 1253
+++ ++ E++ L+ L + + +L ++LE ++ L ++ + +
Sbjct: 953 EKK-MEKVKQKAKEMQETLK--KKLLDQEAKLKKELENT-----ALELSQKEKQFNAKML 1004
Query: 1254 TLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHR 1313
+ Q + +++ + L+ ++ I +LN + W N+ ++EL
Sbjct: 1005 EMAQANSAGISDAVSR----LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
Query: 1314 LETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEV 1373
+ I + E A+L K ++ + + + +E+ +++ E+
Sbjct: 1061 IHEI--QLQEKEQEVAEL-------KQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNEL 1111
Query: 1374 DAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDK 1433
Q KS+ +++ Q D L++ L +++ L +QE+L +L+M
Sbjct: 1112 QEQLKQKSAHVNSLAQ-------DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA 1164
Query: 1434 LPSRHAISEVMSWISLMENVIQ---KDEDNIKNSIGYKAIH-EYLQKYKGFKIDINCKQL 1489
+ +SE+ S + + Q + S+ K++ + L + ++DI CK+
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKK- 1223
Query: 1490 TVDFVNQSVLQISSQDVESKRSDKTD--FAEQLGAMNKSWQILQGLV--TEKIQLLEGLL 1545
+++L+ + ++ + S KT+ + +++ ++ + L+ T + LE L
Sbjct: 1224 -----TEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQL 1278
Query: 1546 ESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQ-DLEDLIKAKE----- 1599
+E +N L F+ +L+++ +N +K + D+E L+ KE
Sbjct: 1279 RQLTEEQNT---LNISFQQATHQLEEK---------ENQIKSMKADIESLVTEKEALQKE 1326
Query: 1600 --KEVEKIEQNGLALIQNKKE-----DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV 1652
+ + + + Q KKE + +++ L+E ++L + L + L++
Sbjct: 1327 GGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNS 1386
Query: 1653 LD------QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQV--QVDNLQNLQDDL 1704
+ SS + +D+ L++ LS F++ T S E + QVD+ N +
Sbjct: 1387 ISLSEKEAAISSLRKQYDEEKCELLDQVQDLS-FKVDTLSKEKISALEQVDDWSNKFSEW 1445
Query: 1705 EKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL 1764
+K+ +S +F N +KE + E + E + + N L EE+ +Q + L
Sbjct: 1446 KKKAQS--RFTQHQN-TVKELQIQL-ELKSKEAYEKDEQINLLKEELDQQNKRFDCL--- 1498
Query: 1765 WQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATW----IQDCNDLLKGLGTV 1820
K + S ++++E LK+ T + + ++ T I+ N++LK
Sbjct: 1499 ----KGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQ 1554
Query: 1821 KD--------SLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQ 1872
KD L ELGE+ +V + + + LE + + L+
Sbjct: 1555 KDIEHKELVQKLQHFQELGEEKDNRVKEA------------EEKILTLENQVYSMKAELE 1602
Query: 1873 AGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLS-TIQERMEELKGQMLKFSSMA 1931
+ E S+++ E + E+ L+ + + ++L ++++ +K Q+L
Sbjct: 1603 TKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS----- 1657
Query: 1932 PDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCET 1991
+ +KE + + H S ++++ ER + + +L+ + L+ E+
Sbjct: 1658 -------------QMEEKEEQYKKGTESHLSELNTKLQER--EREVHILEEK--LKSVES 1700
Query: 1992 WMEFLVQTEQKLAVEISGNYQHLLEQQRAHE--LFQAEMFSRQQILHSIIIDGQRLLEQG 2049
Q+E + + N EQ+ A Q + +L + + ++LL++
Sbjct: 1701 -----SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRV 1755
Query: 2050 QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKW-LVEVSY 2108
+ + + + + +I+ + Q E+ EK +K+ L+ +
Sbjct: 1756 GQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQH 1815
Query: 2109 LPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADS---GAEA 2165
+ G + Q +FD+VQ K ++ LT + +Q + DS +
Sbjct: 1816 VEKEGGKNNIQAKQNLENVFDDVQ---KTLQEKE----LTCQILEQKIKELDSCLVRQKE 1868
Query: 2166 ALQAELAEIQEKWK--SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223
+ E+ E+ K++ A +++ + K L ++ E+ K + KL +
Sbjct: 1869 VHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKS--------HLVQPKLLSN 1920
Query: 2224 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL----NERVE 2279
+ H +L + + + +G ++ +L D+ +L + +E
Sbjct: 1921 MEAQHNDLEFKLAGAEREKQKLGK---EIVRLQ------------KDLRMLRKEHQQELE 1965
Query: 2280 LLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMI 2339
+L++++++ + ++++Q L + + +E L Q E ++ ++ I+E I
Sbjct: 1966 ILKKEYDQE-REEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL----EMTIKETI 2020
Query: 2340 EKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL--- 2396
K ++ E + QE QL + K +E + L + R++ +LD
Sbjct: 2021 NKAQEVEAELLESHQEETNQLLK------------KIAEKDDDLKRTAKRYEEILDAREE 2068
Query: 2397 -IAARVKKLKETLVAVQ-------QLDKNMSSLRTWLAHIESELAK--PIVYDS-CNSEE 2445
+ A+V+ L+ L +Q + ++N + + ++++LA+ ++ DS +E
Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
Query: 2446 IQRKLNEQQELQRDIEKH 2463
+ +++ ++ + EK+
Sbjct: 2129 FREQIHNLEDRLKKYEKN 2146
Score = 122 bits (306), Expect = 6e-27
Identities = 384/2012 (19%), Positives = 773/2012 (38%), Gaps = 302/2012 (15%)
Query: 27 KLTELHQQTIRQAENRLSKLNQAA-SHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ 85
K E QQ +++ EN L + + SH E+ T+ +
Sbjct: 279 KTLETLQQRVKRQENLLKRCKETIQSHKEQC--------------------TLLTSEKEA 318
Query: 86 LREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ--------VAELGRET 137
L+EQ LE+ K++ M EK + +T + + + +Q +AE R+
Sbjct: 319 LQEQLDERLQELEKIKDLH-----MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQM 373
Query: 138 EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQ--------AALEQAQATLTSPEVGRLSL 189
E +M + + L+ K M EL++ + LE+A +T E R L
Sbjct: 374 HETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
Query: 190 K----------EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCH---AA 236
K E+ S + + + E + K + V + + + E+ +A L H A
Sbjct: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKS---SEEQIAKLQKLHEKELA 490
Query: 237 LRLQEEASRLQHTAIQQCNIMQAAV----VQYEQYEQEMKHLQQLIEGAHREIEDKPVAT 292
+ QE +LQ + M+ A+ +Y + QE K Q+ + E++ K + T
Sbjct: 491 RKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE-KEQQESLALEELELQKKAILT 549
Query: 293 SNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV---------- 342
+ +L+ +L Q+ + Y+ +I L S + + K+ + L V
Sbjct: 550 ESENKLR-------DLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 602
Query: 343 -----------TEVEGLAEGTEDLDGELLPT-PSAHPSVVMMTAGRC----HTLLSP--- 383
TE+E L + L E L + + + +C TLL
Sbjct: 603 KEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEI 662
Query: 384 VTEESGEEGTNSEISSPPACRSPSPVANTDAS--VNQDIAYYQALSAERLQTDAAK--IH 439
+ + EE + ++ +++ S + + LS + QTD K +
Sbjct: 663 IFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE 722
Query: 440 PSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQ------ 493
+ ++ ++ +QR+ + LK+ I++ + L E + +++Q
Sbjct: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
Query: 494 --------DSLQSISTKMEAIELKLSESPEPGRSPESQMAE-HQALMD---EILMLQDEI 541
LQ S K++ + S + E ++ E Q+A+ Q L+D E ++L ++
Sbjct: 783 EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV 842
Query: 542 NELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLE 601
E+++ + C A ++ +Q + L ++ S + K Q+ E KL D +
Sbjct: 843 AEVEAQ-----KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK 897
Query: 602 EQRQ---------EQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 652
EQ Q LQ + E++ A D+ +E E + + +
Sbjct: 898 EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE---YETKFKNQEK 954
Query: 653 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE----QLAGKLRRLKGSLLELQRA-- 706
+ +++QK + E + LL+ +A K E E +L+ K ++ +LE+ +A
Sbjct: 955 KMEKVKQKAKEMQETL---KKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS 1011
Query: 707 --LHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELEQ 763
+ D ++ +E+ ES ++ + + + W + + ++ Q +E EQ
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 764 ELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSS------AED 817
E+AE K + EE+ + + G K D EL + ++ S A+D
Sbjct: 1072 EVAELKQKILLFGCEKEEM---NKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD 1128
Query: 818 QMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTS 877
+ ++K E + L +N QEQ L ++L+ +DK V+
Sbjct: 1129 ETKLKAHLEKLEVDLNKSLKENTFLQEQLVEL-----KMLA----------EEDKRKVSE 1173
Query: 878 LLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETE 937
L L EE S ++ + LE K + + ++ ALL +T
Sbjct: 1174 LTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN 1233
Query: 938 TCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVN 997
+ I +A +E L L + L+
Sbjct: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQ 1293
Query: 998 QRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 1057
Q HQ++E+ QI + + D++ L T LQK +Q +E+ I Q + L
Sbjct: 1294 QATHQLEEKENQIKSMKADIESLVTEKE-----ALQKEGGNQQQAASEKESCITQLKKEL 1348
Query: 1058 KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM--MIIGSRRSGLNQNLTLKSQY 1115
E + +K + +VE S+ + +L D+ +L + + + + ++ +L+ QY
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSLSK--QLTDLNVQLQNSISLSEKEAAIS---SLRKQY 1403
Query: 1116 ERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKI 1175
+ +L D ++ K+ K +S+ E++ +K E+ + +S +
Sbjct: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN----- 1458
Query: 1176 ISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETW-----------SHLDEDQQE 1224
KE Q EL + K A+++ ++ + E +++D+ +
Sbjct: 1459 ----TVKELQIQLELKS------KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSK 1508
Query: 1225 LSRQLEVVESSIPS-VGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLIS 1283
+ ++ +E+ + S + E ED + + + L L Y +
Sbjct: 1509 MEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK------------D 1556
Query: 1284 ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLE 1343
I +L +L E N++ + ++ T+ ++E L++ K LE
Sbjct: 1557 IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAE-------LETKKKELE 1609
Query: 1344 FWTQQSVTVPQELEMVRDHLNA-----FLEFSKEVDAQ-SSLKSSVLSTGNQLLRLKKVD 1397
+ +EL+ + D L + E ++ + + +++K +LS + K
Sbjct: 1610 HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG 1669
Query: 1398 TATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKD 1457
T S LS ++++ + + ++EKL ++ + SE + +NV
Sbjct: 1670 T---ESHLSELNTKLQEREREVHILEEKLKSVESSQ-------SETLIVPRSAKNVAAYT 1719
Query: 1458 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT-VDFVNQSVLQISSQDVESKRSDKTDF 1516
E +S G +QK KI + + LT + + Q V Q + V S + +
Sbjct: 1720 EQEEADSQG------CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773
Query: 1517 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 1576
E+L + + + Q + G L+ E +N L +++ K + I
Sbjct: 1774 QERLIKLEHA-----EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGK--NNIQ 1826
Query: 1577 DQASVQNALKDCQDLEDLIKAKEKEV------EKIEQNGLALIQNKKEDVSSIVMSTLRE 1630
+ +++N D Q +EKE+ +KI++ L++ K +V + M L
Sbjct: 1827 AKQNLENVFDDVQK-----TLQEKELTCQILEQKIKELDSCLVRQK--EVHRVEMEELTS 1879
Query: 1631 LGQTWANLDHMVGQLK---ILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSL 1687
+ L M G+ K +L ++ ++ SH V +++ MEA+++ F+ L G+
Sbjct: 1880 KYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN--MEAQHNDLEFK-LAGAE 1936
Query: 1688 EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNL 1747
Q + LQ DL + Q+ I L KE E + +++ ++ N+
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQELEI---LKKEYDQEREEKIKQEQEDLELKHNST 1993
Query: 1748 LEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQE--------DRTNELLKAATNKDIA 1799
L+++ + + L Q Q + K+ + Q+ E + TN+LLK KD
Sbjct: 1994 LKQLMREFNTQ--LAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDD 2051
Query: 1800 DDEVATWIQDCNDLLKGLGT--VKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 1857
A ++ D + T V+D L EL ++ +Q+++ +D +++ +
Sbjct: 2052 LKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPG--NDNVTIME-- 2107
Query: 1858 CALEQALCKQQTSLQAGVLDYETFAKSLEALE 1889
L+ L ++ T + L + F + + LE
Sbjct: 2108 --LQTQLAQKTTLISDSKLKEQEFREQIHNLE 2137
Score = 119 bits (297), Expect = 7e-26
Identities = 400/2146 (18%), Positives = 841/2146 (39%), Gaps = 294/2146 (13%)
Query: 687 EQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTT 746
EQL +LRR++ SL + + Q +EK++ L+ +Q ++ +A+ R
Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRR-IAELREE 195
Query: 747 WTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP------- 799
+Q+ Q+E + L E+K SV +L Q KP
Sbjct: 196 LQMDQQAKKHLQEEFDASL-EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQ 254
Query: 800 -DVLSQELGMEGE-KSSAEDQMRMKW-ESLHQEFSTKQKLLQNVLEQEQ----------- 845
+V ++E E + + ED +K E+L Q ++ LL+ E Q
Sbjct: 255 AEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTS 314
Query: 846 -EQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSG---GAKRQSI 901
++ L + + L + K + +T L D N E++ G ++ +
Sbjct: 315 EKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKN-LIEQLEQDKGMVIAETKRQM 373
Query: 902 H--LEQK------LYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEM 953
H LE K L + +T +++ E+ + EE E L + + +++
Sbjct: 374 HETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
Query: 954 SEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNF 1013
EMD+ + E R+SL Q ++K+ + ++
Sbjct: 434 KAEMDEQIKTIEKTSEEE----------------RISL-----QQELSRVKQEVVDVMKK 472
Query: 1014 QNDLKVLFTSLADNKYIIL--QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRG 1071
++ ++ K + Q+L + E E ++ A + + I + K +
Sbjct: 473 SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQ 532
Query: 1072 DKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ-------DLAD 1124
+ L +E+ +Q+ + L + ++L + + + L L+S E++LQ DLA
Sbjct: 533 ESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAV 592
Query: 1125 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 1184
LE + K +EI +++KHK + L+ T +++ Q E
Sbjct: 593 HLEAEKNK----------HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEM 642
Query: 1185 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 1244
+ E Q L + + E I + +H++E ++ +L+V ++ + S L E
Sbjct: 643 EKLREKCEQEKETLLK------DKEIIFQ--AHIEEMNEKTLEKLDVKQTELES--LSSE 692
Query: 1245 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 1304
+ L R L + L S L + K+ Q L+ + ++S + + E + T
Sbjct: 693 LSEVLKARHKLEEEL-SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKE-HEVSIQRT 750
Query: 1305 NKMSKE-LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHL 1363
K K+ +++LE +LK ++ E + L++ R E EL+ L
Sbjct: 751 EKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE----------GELQQASAKL 800
Query: 1364 NAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQ 1423
+ F + Q+ L+ Q L + + L +++ +++Q D+ T + A +
Sbjct: 801 DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHK 860
Query: 1424 EKLHQLQMDKLPSRHAISE--VMSWISLMENVIQ---KDEDNIKNSIGYKAIHEYLQKYK 1478
++ L M +L +++ E V S + E+ ++ K+++ K + K + LQ +
Sbjct: 861 IQVQDL-MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE-NMILQMRE 918
Query: 1479 GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKI 1538
G K +I + S+ I +++ E+K ++ E++ K Q T K
Sbjct: 919 GQKKEIEILTQKLSAKEDSI-HILNEEYETKFKNQEKKMEKVKQKAKEMQ-----ETLKK 972
Query: 1539 QLLEGLLESWSEYENNVQCL---KTWFETQEKRLKQQHRIGDQASVQNA-LKDCQDLEDL 1594
+LL+ + E EN L + F + + Q + G +V + +E L
Sbjct: 973 KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESL 1032
Query: 1595 IKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLD 1654
+ +E+ + + + E++ I L+E Q A L KILL
Sbjct: 1033 TEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQ-----KILLFGCEK 1087
Query: 1655 QWSSHKVAF-----DKINSYLMEARYSLSRFRLLTGSLEAVQVQVD-NLQNLQDDLEK-- 1706
+ + ++ + K ++ L E + L + SL + ++ +L+ L+ DL K
Sbjct: 1088 EEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Query: 1707 QERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQ 1766
+E + + + ++L E LT+ LK + + +L + +S+K+L
Sbjct: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLK---SSHEKSNKSLEDKSL 1204
Query: 1767 RYKDYSKQ--------CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLG 1818
+K S++ C T E +TNEL+ +++K A + + I C
Sbjct: 1205 EFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNA---ILSRISHCQHRTT--- 1258
Query: 1819 TVKDSLFF----LHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAG 1874
VK++L + EL QL+Q + I Q + L E + + +++
Sbjct: 1259 KVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT--HQLEEKENQIKSMKADIESL 1316
Query: 1875 VLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDL 1934
V + E K + E E + S +++ + EELK + ++ SS++ L
Sbjct: 1317 VTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL 1376
Query: 1935 DRLN-ELGYRLPLNDKEIKRMQNLNRHWSL----ISSQTTERFSKLQSFLLQHQTFLEKC 1989
LN +L + L++KE + +L + + + Q + K+ + + + LE+
Sbjct: 1377 TDLNVQLQNSISLSEKEAA-ISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQV 1435
Query: 1990 ETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG 2049
+ W + ++K + + + E Q EL E + + + ++ +
Sbjct: 1436 DDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLL----------- 1484
Query: 2050 QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR-QWQRYREMAEKLRKWLVEVSY 2108
++ D+ N + L + + + +++ ++++++ Q R E+ + + + +E+
Sbjct: 1485 -KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIE- 1542
Query: 2109 LPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQ 2168
L V Q + +++ KE V Q E G++ D+ + A +
Sbjct: 1543 ----SLNEVLKNYNQQK----DIEHKELVQKLQHFQ-----ELGEE----KDNRVKEA-E 1584
Query: 2169 AELAEIQEKWKSASMRLEEQKKKLAFL---LKDWEKCEKGIADSLE-----KLRTFKKKL 2220
++ ++ + S LE +KK+L + +K E+ K + D LE KL K+K
Sbjct: 1585 EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA 1644
Query: 2221 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 2280
Q + ++L QM KE + G+ +S LN +++
Sbjct: 1645 EQKIAAIKKQL-LSQMEEKEEQYKKGT--------------------ESHLSELNTKLQE 1683
Query: 2281 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 2340
+R+ H L + + + +E + K + + T+ E SQ
Sbjct: 1684 RERE----VHILEEKLKSVESSQSETLIVPRSAKNVAAY-TEQEEADSQGC--------- 1729
Query: 2341 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 2400
++K Y+E+I++ Q N + +++ +R+ + E+ +S E +
Sbjct: 1730 -VQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRC----------------- 1771
Query: 2401 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 2460
+ +E L+ ++ + ++ + H++ EL EE +K + +
Sbjct: 1772 --QYQERLIKLEHAEAKQHEDQSMIGHLQEEL-----------EEKNKKYSLIVAQHVEK 1818
Query: 2461 EKHSTGVASVLNLCEVLLHDCDACATDAE--CDSIQQATRNLDRRWRNICAMSME--RRL 2516
E + + NL E + D + E C ++Q + LD C + + R+
Sbjct: 1819 EGGKNNIQAKQNL-ENVFDDVQKTLQEKELTCQILEQKIKELDS-----CLVRQKEVHRV 1872
Query: 2517 KIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHEC 2576
++EE ++K L + + K +E + V + L EA +
Sbjct: 1873 EMEELTSKYEK-LQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFK 1931
Query: 2577 LT----QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIG 2632
L + + + K+ RL ++ L+ + E Q + L+K R +
Sbjct: 1932 LAGAEREKQKLGKEIVRLQKD--------LRMLRKEHQQELEILKKEYDQ--EREEKIKQ 1981
Query: 2633 QREEFETARDSILVWL-TEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH----NKI 2687
++E+ E +S L L E + QL E E ++ I + + + E+ +H N++
Sbjct: 1982 EQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQL 2041
Query: 2688 EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 2733
+ IA+ + ++++ I++ +E+ +++ ++E KK
Sbjct: 2042 LKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK 2087
Score = 103 bits (256), Expect = 4e-21
Identities = 314/1655 (18%), Positives = 648/1655 (39%), Gaps = 288/1655 (17%)
Query: 28 LTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGT--IAWNSASQ 85
+ E++++T+ + + + ++L +S L +E+L+ K E+ VL T + ++
Sbjct: 668 IEEMNEKTLEKLDVKQTELESLSSEL---SEVLKARHKLEEELSVLKDQTDKMKQELEAK 724
Query: 86 LREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEK-MSQQVAELGRETEELRQMI 144
+ EQ HQ +++DS ++ ++ S+ TEK + Q+ +L +E + +
Sbjct: 725 MDEQKNHHQ------QQVDSIIK------EHEVSIQRTEKALKDQINQLELLLKERDKHL 772
Query: 145 KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEME 204
K ++++ D+K+ E EL++ A L+ Q+ ++ + +EQL+ Q L ++E
Sbjct: 773 KEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLE 832
Query: 205 SLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 264
+ E ++ + + + ++ + L IQ ++MQ Q
Sbjct: 833 T------------------ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQN 874
Query: 265 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 324
+ EQ++K L Q+ E ++ED Q Q + + + Q +G +++I L
Sbjct: 875 SEMEQKVKSLTQVYES---KLEDG--NKEQEQTKQILVEKENMILQMREGQKKEIEILTQ 929
Query: 325 KCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPV 384
K + AK ++ + E E + E V TL +
Sbjct: 930 K-----LSAKEDSIHILNEEYETKFKNQE----------KKMEKVKQKAKEMQETLKKKL 974
Query: 385 TEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS- 443
++ + + NT ++Q + A E Q ++A I + S
Sbjct: 975 LDQE--------------AKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSR 1020
Query: 444 --ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIST 501
+Q+ L +L D+ WE N +E+ + ++E ++ Q+K Q
Sbjct: 1021 LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE-IQLQEKEQ-------- 1071
Query: 502 KMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADP 561
E ELK + G E E L +E + +NELQ L ++ S +
Sbjct: 1072 --EVAELK-QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK--SAHVNSLA 1126
Query: 562 AEQLALQSTLTVL-AERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 620
++ L++ L L + +++ + QL+E K+ + ++++ + + + +E
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQ 1186
Query: 621 SWL----LSTKATLDTALSPPKEPMDMEAQL-MDCQNMLVEIEQKVVALSELSVHNENLL 675
S S K+ D +L K ++ QL + C+ +E K L +S N +
Sbjct: 1187 SLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAI 1246
Query: 676 LEGKAHTKDEAEQLAGKL-------RRLKGSLLELQRALHDKQLNMQGTAQEKEE----- 723
L +H + ++ L L+ L +L + ++ Q + EE
Sbjct: 1247 LSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQI 1306
Query: 724 ----SDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKEL----------EQELAEQK 769
+D++ T+ +Q+ + +++ Q +KEL ++EL E+K
Sbjct: 1307 KSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKK 1366
Query: 770 SLLRSVASRGEE--ILIQHSAAETSGDAG----------EKPDVLSQELG-------MEG 810
+ S++ + + + +Q+S + + +A EK ++L Q +
Sbjct: 1367 VEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK 1426
Query: 811 EKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQ 870
EK SA +Q+ + +FS +K Q+ Q Q V + L Y+ D +
Sbjct: 1427 EKISALEQV----DDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD---E 1479
Query: 871 DKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATA 930
+ + LD N+ F+ + + K + E L + + + + ++E+ + T
Sbjct: 1480 QINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTI 1539
Query: 931 LLPEETETCL-FNQEILAKDI--KEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLG 987
+ E +NQ+ KDI KE+ +++ Q F E G+ +D
Sbjct: 1540 EIESLNEVLKNYNQQ---KDIEHKELVQKL--------QHFQELGEEKD----------- 1577
Query: 988 RLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI 1047
+++KE ++IL +N + + L K ++L +V V +
Sbjct: 1578 -------------NRVKEAEEKILTLENQVYSMKAELETKK----KELEHV-NLSVKSKE 1619
Query: 1048 EAIQQAEDGLK-EFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLN 1106
E ++ ED L+ E A + ELKR+ ++ ++ Q LS++++ ++ S S LN
Sbjct: 1620 EELKALEDRLESESAAKLAELKRKAEQ-KIAAIKKQLLSQMEEKEEQYKKGTESHLSELN 1678
Query: 1107 QNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGL----- 1161
L + + L++ +E+ Q + I+ S + + ++ + QG
Sbjct: 1679 TKLQEREREVHILEEKLKSVESSQ----SETLIVPRSAKNVAAYTEQEEADSQGCVQKTY 1734
Query: 1162 -ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDE 1220
E +L L K +Q+ Q E ++ + + +R ++LE+ E H E
Sbjct: 1735 EEKISVLQRNLTEK--EKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEH-AEAKQH--E 1789
Query: 1221 DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPK--LYQVLDDGK 1278
DQ + E +E L+ + + + N Q K L V DD +
Sbjct: 1790 DQSMIGHLQEELEEKNKKYSLI----------VAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 1279 RLL--ISISCSDLESQLNQLGECWLSNTNKMSKELHRLE--------------------- 1315
+ L ++C LE ++ +L C + KE+HR+E
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLV-----RQKEVHRVEMEELTSKYEKLQALQQMDGRN 1894
Query: 1316 ---TILKHWTRYQSES----ADLIHWLQSAKDRLEF-----------WTQQSVTVPQELE 1357
+L+ T +S+S L+ +++ + LEF ++ V + ++L
Sbjct: 1895 KPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLR 1954
Query: 1358 MVR-DHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDT--ATLRSELSRIDSQWTD 1414
M+R +H KE D + K + + L LK T +R +++ + +
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEK---IKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE 2011
Query: 1415 LLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYL 1474
L I K +++ + L S + L++ + +KD+D + + Y+ I
Sbjct: 2012 LEMTIKETINKAQEVEAELLESHQEETN-----QLLKKIAEKDDDLKRTAKRYEEI---- 2062
Query: 1475 QKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV 1534
+D +++T + LQ ++++ K K + E G N + LQ +
Sbjct: 2063 -------LDAREEEMTAKVRD---LQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQL 2112
Query: 1535 TEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRL 1569
+K L+ E+ + L+ + EK +
Sbjct: 2113 AQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
Score = 102 bits (254), Expect = 6e-21
Identities = 456/2427 (18%), Positives = 942/2427 (38%), Gaps = 461/2427 (18%)
Query: 834 QKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQS 893
+KL Q + E++Q+ P + S PT+ +S +S + L++ S
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSN-----SSTPTRMRSRTSSFTEQLDEGTPNRESGD 57
Query: 894 GGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAK-DIKE 952
+ Q + L S S + ++E LF +++ +E+ ++E L + D+
Sbjct: 58 TQSFAQKLQLRVP-----SVESLFRSPIKESLFRSSS---KESLVRTSSRESLNRLDLDS 109
Query: 953 MSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN 1012
+ D ++ S+A G++ + ++ L + RL ++ ++ + E +
Sbjct: 110 STASFDPPSDMDSEAEDLVGNSDSLNKEQL---IQRLRRMERSLSSYRGKYSELVTAYQM 166
Query: 1013 FQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKE-FDAGIIELKRRG 1071
Q + K L L+ ++ L+++A + E+++ QQA+ L+E FDA + E +
Sbjct: 167 LQREKKKLQGILSQSQDKSLRRIAEL-----REELQMDQQAKKHLQEEFDASLEEKDQYI 221
Query: 1072 DKLQVEQPSMQELSKLQDMYDELMMIIGS---RRSGLNQNLTLKSQYERALQDLADL--L 1126
LQ + +++ + M +++ + + + +S E ++D + L
Sbjct: 222 SVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTL 281
Query: 1127 ETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHM-ILTETL------FRKIISFA 1179
ET Q+++ + ++ KE IQ HKE L S L E L KI
Sbjct: 282 ETLQQRVKRQENLLKRCKETIQS----HKEQCTLLTSEKEALQEQLDERLQELEKIKDLH 337
Query: 1180 VQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 1239
+ ++T+ T+L + + + +G+ + E ++++ LE+ E I +
Sbjct: 338 MAEKTKLITQLRDAKNLIEQLEQDKGMVIA----------ETKRQMHETLEMKEEEIAQL 387
Query: 1240 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 1299
R+ T + L+ + + ++ L+ K L + + +L +
Sbjct: 388 ------RSRIKQMTTQGEELREQKEKSERAAFEELE--KALSTAQKTEEARRKLKAEMDE 439
Query: 1300 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMV 1359
+ K S+E R+ ++ + +R + E D++ +S+++++ + +EL
Sbjct: 440 QIKTIEKTSEE-ERI-SLQQELSRVKQEVVDVMK--KSSEEQI---AKLQKLHEKELARK 492
Query: 1360 RDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNI 1419
L L+ ++E + Q +K ++ + ++ L++ + L ++ Q +LT
Sbjct: 493 EQELTKKLQ-TREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTES 551
Query: 1420 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 1479
+ KL LQ + R I E +E+ ++K KN A+H +K K
Sbjct: 552 ---ENKLRDLQQEAETYRTRILE-------LESSLEKSLQENKNQSKDLAVHLEAEKNK- 600
Query: 1480 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 1539
+ K++TV VE +++ Q A+ W TEK+Q
Sbjct: 601 -----HNKEITVM-------------VEKHKTELESLKHQQDAL---W-------TEKLQ 632
Query: 1540 LLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKE 1599
+L+ +Y+ ++ L+ E +++ L + I QA ++ + E
Sbjct: 633 VLK------QQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIE-------------EMNE 673
Query: 1600 KEVEKIEQNGLALIQNKKEDVSSIVMSTLR---ELGQTWANLDHMVGQLKILLKSVLDQW 1656
K +EK++ Q + E +SS + L+ +L + + L ++K L++ +D+
Sbjct: 674 KTLEKLDVK-----QTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728
Query: 1657 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 1716
+H +++S + E S+ R +A++ Q++ L+ L + +K
Sbjct: 729 KNHHQ--QQVDSIIKEHEVSIQRTE------KALKDQINQLELLLKERDKH--------- 771
Query: 1717 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 1776
LKE H E L +K +LQ + A L ++Q Y+ + +
Sbjct: 772 -----LKE-HQAHVENLEADIKRSE-----------GELQQASAKLDVFQSYQSATHEQT 814
Query: 1777 STVQQQEDRTNE-LLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLK 1835
++Q + + LL T + + +VA D+ L K + +L +QL+
Sbjct: 815 KAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV---QDLMQQLE 871
Query: 1836 QQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEA 1895
+Q + Q + +L Q ++ L+ G K E + +VE
Sbjct: 872 KQ------------NSEMEQKVKSLTQVY---ESKLEDG-------NKEQEQTKQILVEK 909
Query: 1896 EEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQ 1955
E ++ L + + +E++ K S+ + LNE Y ++E K+M+
Sbjct: 910 ENMI----------LQMREGQKKEIEILTQKLSAKEDSIHILNE-EYETKFKNQE-KKME 957
Query: 1956 NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLL 2015
+ Q E ET + L+ E KL E+ L
Sbjct: 958 KVK------------------------QKAKEMQETLKKKLLDQEAKLKKELENT---AL 990
Query: 2016 EQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFN----LKLTLLSNQWQGV 2071
E + + F A+M Q + I D LE Q + + +L + + W+
Sbjct: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK 1050
Query: 2072 I-RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV----------EVSYLPMSGLGSVPIP 2120
+ ++A++ + I + Q+++ + +E+AE +K L+ E+++L G+
Sbjct: 1051 LNQQAEELQEIHEIQLQE--KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGV------ 1102
Query: 2121 LQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAE---IQEK 2177
+ T +E+Q + L+Q+ +++ ++ + L + E L L E +QE+
Sbjct: 1103 --KQDTTLNELQEQ----LKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
Query: 2178 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH-------EE 2230
M EE K+K++ L + + + + L++ +K ++SL D EE
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTD----EEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1212
Query: 2231 LHAE-QMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC 2289
L + + CK+ E + + T++L IS+ + + R+ Q + ++
Sbjct: 1213 LAIQLDICCKKTEALLEAKTNELIN-----------ISSSKTNAILSRISHCQHRTTKVK 1261
Query: 2290 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEE 2349
L ++ + E + +E+ L Q ++ + E I+ +K D +
Sbjct: 1262 EALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEK-----ENQIKSMKADIESL 1316
Query: 2350 IAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV 2409
+ K LQ+ G + + ASE E + ++ ++ + ++LKE V
Sbjct: 1317 VT----EKEALQKEG-----GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKV 1367
Query: 2410 AVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVAS 2469
+ L K ++ L L + S K S Q D EK
Sbjct: 1368 EISSLSKQLTDLNVQLQNSISLSEKEAAISSLRK-------------QYDEEK------- 1407
Query: 2470 VLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFL 2529
CE+L D +Q + +D +S E+ +E+ +
Sbjct: 1408 ----CELL-------------DQVQDLSFKVD-------TLSKEKISALEQ--------V 1435
Query: 2530 DDYS-RFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYR 2588
DD+S +F +W K ++ +F Q V E QLEL +K+
Sbjct: 1436 DDWSNKFSEWKKKAQ--------------------SRFTQHQNTVKELQIQLELKSKE-- 1473
Query: 2589 RLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWL 2648
+ + LK+ + + N+R+D L+ + +++ + ET S +
Sbjct: 1474 ---AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK---KESNLETELKSQTARI 1527
Query: 2649 TEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAI 2708
E++ +T ++++ + LK + Q+ + H ++ Q + ++L E+ +
Sbjct: 1528 MELEDHITQ----KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDN-RVKE 1582
Query: 2709 IEEELDELRRYCQEVFGRVERYHKKL--IRLPLPDDEHDLSDRE--LELEDSAALSDLHW 2764
EE++ L + +E K+L + L + E +L E LE E +A L++L
Sbjct: 1583 AEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAEL-- 1640
Query: 2765 HDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMS 2824
R A+ ++ LS + + + G ++ S + L+ R+ E +
Sbjct: 1641 -KRKAEQKIAAIKKQLLS-QMEEKEEQYKKGTESHLSELNTKLQ-------EREREVHIL 1691
Query: 2825 RALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSK- 2883
E Q + R A ++ E+ + + + + + Q + K
Sbjct: 1692 EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL 1751
Query: 2884 -TPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI 2942
G E + + + ++ + + ++ E K + E++S+ G + E
Sbjct: 1752 LQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK-QHEDQSMIGHLQEELEEKN----- 1805
Query: 2943 DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 3002
++ L+ AQ + KE K N+Q Q + + + + LQ EL T
Sbjct: 1806 KKYSLIVAQHVEKE-GGKNNIQAKQNLENVFDDV----------QKTLQEKEL-----TC 1849
Query: 3003 ELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLL 3062
++ +K+KEL + +K + E + SK + L QM+GR ++ LL
Sbjct: 1850 QILEQKIKELDSCLVRQKEV------HRVEMEELTSKYEK--LQALQQMDGR-NKPTELL 1900
Query: 3063 EE------WRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK----NEIVPIDSNLDAEIL 3112
EE L+Q L+ + L L +R K EIV + D +L
Sbjct: 1901 EENTEEKSKSHLVQPKLL--SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQK--DLRML 1956
Query: 3113 QDHHKQLMQI--------KHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 3164
+ H+Q ++I + E ++ + L+ S + E L KE+
Sbjct: 1957 RKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ------ 2010
Query: 3165 RLKLLLKEVSRHIKELEKLLDVSSSQQ 3191
L++ +KE +E+E L S ++
Sbjct: 2011 ELEMTIKETINKAQEVEAELLESHQEE 2037
Score = 91.3 bits (225), Expect = 1e-17
Identities = 320/1585 (20%), Positives = 637/1585 (40%), Gaps = 246/1585 (15%)
Query: 1823 SLFFLHELGEQLKQQVDASAASAIQSD-QLSLS---QHLCALEQALCKQQTSLQAGVLDY 1878
SL + EL E+L Q+D A +Q + SL Q++ L+ + + L+ G ++
Sbjct: 185 SLRRIAELREEL--QMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNV 242
Query: 1879 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 1938
+ K L LE +AE + ++P SD + E +K L
Sbjct: 243 DVL-KPLPQLEP---QAEVFTKEENPE--SDGEPVVEDGTSVK--------------TLE 282
Query: 1939 ELGYRLPLNDKEIKR----MQNLNRHWSLISS-------QTTERFSKLQSFLLQHQTFLE 1987
L R+ + +KR +Q+ +L++S Q ER +L+ H
Sbjct: 283 TLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKT 342
Query: 1988 KCETWME----FLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQ 2043
K T + + Q EQ + I+ + + E E A++ SR + + G+
Sbjct: 343 KLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR---IKQMTTQGE 399
Query: 2044 RLLEQGQVDDRDEFN-LKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE-----MAE 2097
L EQ + +R F L+ L + Q RR + + +D QI+ ++ E + +
Sbjct: 400 ELREQKEKSERAAFEELEKALSTAQKTEEARR--KLKAEMDEQIKTIEKTSEEERISLQQ 457
Query: 2098 KLRKWLVEVSYLPMSGLGSVPIPLQQA---------RTLFDEVQFKEKVFLRQQGSYILT 2148
+L + EV + LQ+ + L ++Q +E+ F ++Q L
Sbjct: 458 ELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREF-QEQMKVALE 516
Query: 2149 VEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD 2208
+ L +S + + +L E E+Q+K L E + KL L ++ E I +
Sbjct: 517 KSQSEYLKISQEKEQQESLALEELELQKK-----AILTESENKLRDLQQEAETYRTRILE 571
Query: 2209 ---SLEKLRTFKKKLSQSLPDHHEELHAEQMRC-KELENAVGSWTDDLTQLSLLKDTLSA 2264
SLEK K S+ L H L AE+ + KE+ V +L L +D L
Sbjct: 572 LESSLEKSLQENKNQSKDLAVH---LEAEKNKHNKEITVMVEKHKTELESLKHQQDAL-- 626
Query: 2265 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNE------WAVFSEKNKELCE 2318
E++++L++Q++ +L + +Q E L + A E N++ E
Sbjct: 627 ---------WTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLE 677
Query: 2319 WL----TQMESKVSQNGDIL-----IEEMIEKLK----KDYQEEIAIAQENKIQLQQMGE 2365
L T++ES S+ ++L +EE + LK K QE A E K QQ +
Sbjct: 678 KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVD 737
Query: 2366 RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 2425
+ K HE E L D+ L L+ R K LKE V+ L+ ++ L
Sbjct: 738 SIIK-EHEVSIQRTEKAL---KDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGEL 793
Query: 2426 AHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI-EKHSTGVASVLNLCEVLLHDCDAC 2484
++L Y S E+ + + +LQ+ + + + + + EV D C
Sbjct: 794 QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVC 853
Query: 2485 AT-DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-- 2541
DA +Q + L+++ + E K++ ++++ L+D ++ ++ K
Sbjct: 854 TELDAHKIQVQDLMQQLEKQ-------NSEMEQKVKSLTQVYESKLEDGNKEQEQTKQIL 906
Query: 2542 ---------------------SERTAAFPSSSGVIY----TVAKEELKKFEAFQRQVHEC 2576
+++ +A S ++ T K + KK E +++ E
Sbjct: 907 VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEM 966
Query: 2577 LTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKR----VTSILRRLKHFIG 2632
L+ ++ ++A L Q + N + + + ++ + RL+
Sbjct: 967 QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLE--TN 1024
Query: 2633 QREEFETA--------RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH 2684
Q+E+ E+ D I +W +++ Q ++ E +Q K +++ +Q+I L
Sbjct: 1025 QKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFG 1084
Query: 2685 NKIEQIIAQGEQLIEKSEPLDAAI--IEEELDELRRYCQEVFGRVERYHKKLIRLPLP-- 2740
+ E++ + L E+ D + ++E+L + + + + L +L +
Sbjct: 1085 CEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLN 1144
Query: 2741 ---DDEHDLSDRELEL-----EDSAALSDLHWHDRSAD----SLLSPQPSSNLSLSLAQP 2788
+ L ++ +EL ED +S+L ++ D SL S SN SL +
Sbjct: 1145 KSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE-DKS 1203
Query: 2789 LRSERSGRDTPASVDSIPLEWDHDYDLSRD----LESAMSRALPSEDEEGQDDKDFYLRG 2844
L ++ + +D + + + + + S+ + A+ S Q
Sbjct: 1204 LEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEA 1263
Query: 2845 AVGLSGDHSALESQIRQLGK-------ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGY 2897
+ + S LE+Q+RQL + + + Q+++ EN I+S L T +
Sbjct: 1264 LLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL 1323
Query: 2898 MK------------------LLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 2939
K L E S +I++V ++ +LKE++ V + S Q
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKK------VEISSLSKQLT 1377
Query: 2940 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 2999
+ +L + +LS++ +L+K Q++ + + + D +++ L + ++S +
Sbjct: 1378 DL--NVQLQNSISLSEKEAAISSLRK--QYDEEKCELLDQVQDLSFKVDTLSKEKISA-L 1432
Query: 3000 QTIELQIKKLKELQKAVDHR--------KAIILSINLCSPEFTQADSKESRDLQDRLSQM 3051
+ ++ K E +K R K + + + L S E + D + + L++ L Q
Sbjct: 1433 EQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL-LKEELDQQ 1491
Query: 3052 NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN-IDRRKNEIVPIDSNLDAE 3110
N R+D + +E+ + ++ + + ++ LE+ I ++ EI ++ E
Sbjct: 1492 NKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLN-----E 1546
Query: 3111 ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLL 3170
+L+++++Q I+H+ L +L+ Q L + EA+EK+ + N++ +
Sbjct: 1547 VLKNYNQQ-KDIEHKELVQKLQ-------HFQELGEEKDNRVKEAEEKILTLENQVYSMK 1598
Query: 3171 KEVSRHIKELEKL-LDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSL 3229
E+ KELE + L V S +++L + D L+ S ++ + ++K + ++
Sbjct: 1599 AELETKKKELEHVNLSVKSKEEELKALE--DRLE-----SESAAKLAELKRKAEQKIAAI 1651
Query: 3230 SQPGPSVSSPHSRSTKGGSDSSLSE 3254
+ S K G++S LSE
Sbjct: 1652 KKQLLSQMEEKEEQYKKGTESHLSE 1676
Score = 34.3 bits (77), Expect = 2.1
Identities = 44/211 (20%), Positives = 95/211 (45%), Gaps = 29/211 (13%)
Query: 16 QLGKP---LAKKIGKLTELHQQTIR-----QAENRLSKLNQAASHLE-EYNEMLELILKW 66
+LGK L K + L + HQQ + + R K+ Q LE ++N L+ +++
Sbjct: 1941 KLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMRE 2000
Query: 67 I--------EKAKVLAHGTIAWNSASQLREQYI-LHQT----LLEESKEIDSELEAMTEK 113
++ ++ TI N A ++ + + HQ LL++ E D +L+ ++
Sbjct: 2001 FNTQLAQKEQELEMTIKETI--NKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKR 2058
Query: 114 LQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE 173
+ + E+M+ +V +L + EEL++ + +L+ ++ D + +LQ L
Sbjct: 2059 YEEILDAR-EEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGND----NVTIMELQTQLA 2113
Query: 174 QAQATLTSPEVGRLSLKEQLSHRQHLLSEME 204
Q ++ ++ +EQ+ + + L + E
Sbjct: 2114 QKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 116,150,189
Number of Sequences: 37866
Number of extensions: 5132297
Number of successful extensions: 34189
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 848
Number of HSP's that attempted gapping in prelim test: 20325
Number of HSP's gapped (non-prelim): 7556
length of query: 3321
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3200
effective length of database: 13,665,732
effective search space: 43730342400
effective search space used: 43730342400
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.