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Search of human proteins with 153946391
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
(1336 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 2783 0.0
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 1106 0.0
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 976 0.0
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 976 0.0
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 976 0.0
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 938 0.0
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 288 2e-77
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 276 7e-74
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 263 8e-70
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 263 8e-70
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 263 8e-70
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 186 1e-46
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 185 3e-46
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 179 2e-44
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 179 2e-44
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 179 2e-44
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 179 2e-44
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 179 2e-44
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 175 2e-43
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 175 2e-43
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 174 4e-43
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 174 4e-43
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 174 5e-43
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 171 3e-42
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 171 4e-42
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 167 5e-41
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 167 5e-41
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 164 5e-40
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 164 5e-40
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 80 1e-14
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor [Homo
sapiens]
Length = 1336
Score = 2783 bits (7214), Expect = 0.0
Identities = 1336/1336 (100%), Positives = 1336/1336 (100%)
Query: 1 MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGP 60
MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGP
Sbjct: 1 MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGP 60
Query: 61 AYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDD 120
AYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDD
Sbjct: 61 AYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDD 120
Query: 121 SRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLE 180
SRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLE
Sbjct: 121 SRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLE 180
Query: 181 EYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVS 240
EYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVS
Sbjct: 181 EYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVS 240
Query: 241 AQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPL 300
AQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPL
Sbjct: 241 AQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPL 300
Query: 301 PAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESL 360
PAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESL
Sbjct: 301 PAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESL 360
Query: 361 HRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG 420
HRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG
Sbjct: 361 HRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG 420
Query: 421 RFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPE 480
RFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPE
Sbjct: 421 RFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPE 480
Query: 481 KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSL 540
KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSL
Sbjct: 481 KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSL 540
Query: 541 TINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVT 600
TINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVT
Sbjct: 541 TINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVT 600
Query: 601 VFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVL 660
VFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVL
Sbjct: 601 VFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVL 660
Query: 661 VWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEK 720
VWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEK
Sbjct: 661 VWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEK 720
Query: 721 NIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGS 780
NIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGS
Sbjct: 721 NIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGS 780
Query: 781 GKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKL 840
GKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKL
Sbjct: 781 GKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKL 840
Query: 841 DIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAE 900
DIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAE
Sbjct: 841 DIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAE 900
Query: 901 AAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADG 960
AAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADG
Sbjct: 901 AAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADG 960
Query: 961 FHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPP 1020
FHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPP
Sbjct: 961 FHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPP 1020
Query: 1021 AGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAG 1080
AGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAG
Sbjct: 1021 AGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAG 1080
Query: 1081 GTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYP 1140
GTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYP
Sbjct: 1081 GTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYP 1140
Query: 1141 YAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHD 1200
YAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHD
Sbjct: 1141 YAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHD 1200
Query: 1201 GLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGW 1260
GLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGW
Sbjct: 1201 GLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGW 1260
Query: 1261 DLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDL 1320
DLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDL
Sbjct: 1261 DLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDL 1320
Query: 1321 GTRRGSAHFSSLESEV 1336
GTRRGSAHFSSLESEV
Sbjct: 1321 GTRRGSAHFSSLESEV 1336
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [Homo
sapiens]
Length = 1233
Score = 1106 bits (2861), Expect = 0.0
Identities = 597/1037 (57%), Positives = 714/1037 (68%), Gaps = 67/1037 (6%)
Query: 40 GPGGGLGGARPLNVALVFS--GPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPR 97
GPG G G + VA+VFS GP A ARL P + L+++P+ + +N ++P
Sbjct: 22 GPGQGEQG---MTVAVVFSSSGPPQAQFRARLTPQ---SFLDLPLEIQPLTVGVNTTNPS 75
Query: 98 SLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEK 157
SL+ Q+C LL VHG+VFED+ AVA ILDF+S+QT +PI+++ GG+A+VLTPKE
Sbjct: 76 SLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEP 135
Query: 158 GSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEH 217
GS FLQLG S EQQLQV+F+VLEEYDW++F +T+ PGH FL + + D S V W
Sbjct: 136 GSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRL 195
Query: 218 RGALTLD--PGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMV 275
+TL+ PG A LR + A + + +C+REEAE +F A +AGL G G+VW +
Sbjct: 196 LDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLV- 254
Query: 276 GPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALL 335
P LA G P A P GL +V + WR L ++V GVA++A GA +
Sbjct: 255 -PNLALGSTDAPP---------ATFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYW 304
Query: 336 RDYGFLPELGHDCRAQNRTHRG------ESLHRYFMNITWDNRDYSFNEDGFLVNPSLVV 389
R +G LP DCR H G E+ +R+ +N+TW+ RD+SF+ G+LV P++VV
Sbjct: 305 RQHGTLPAPAGDCRV----HPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV 360
Query: 390 ISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPAD 449
I+L R R WE+VG WE L +KYP+W RY LQPV D++HLTVATLEERPFVIVE D
Sbjct: 361 IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD 420
Query: 450 PISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVT 509
P +G C+ ++VPCR Q N T S AP K CCKGFCIDILK+LA + FSYDLYLVT
Sbjct: 421 PGTGGCVPNTVPCRRQSNHTFSSGDVAPYT-KLCCKGFCIDILKKLARVVKFSYDLYLVT 479
Query: 510 NGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN 569
NGKHGK++ GVWNGMIGEV+Y+RADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN
Sbjct: 480 NGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN 539
Query: 570 GTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTI 629
GTVSPSAFLEPYSPAVWVMMFVMCLTVVA+TVF+FEY SPV YN++L GK+ GG FTI
Sbjct: 540 GTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTI 599
Query: 630 GKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDT 689
GKS+WLLWALVFNNSVP+ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQE+Y+DT
Sbjct: 600 GKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDT 659
Query: 690 VSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLK 749
VSGLSD+KFQRPQ+QYPP +FGTVPNGSTE+NIRSNY DMH++MV++NQ VE+ALT LK
Sbjct: 660 VSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLK 719
Query: 750 AGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQ 809
GKLDAFIYDAAVLNYMA KDEGCKLVTIGSGKVFATTGYGIA+ K S WKR IDLALLQ
Sbjct: 720 MGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQ 779
Query: 810 FLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLV 869
FLGD E + LE +WLSGIC N+K EVMSSKLDIDNMAGVFYMLLVAMGL+LLVFAWEHLV
Sbjct: 780 FLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLV 839
Query: 870 YWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGP 929
YW+LRH + + ++DFLLAFSRG+YSC S Q L SP PR A P
Sbjct: 840 YWKLRHSVPNSSQLDFLLAFSRGIYSCFSG------------VQSLASP----PRQA-SP 882
Query: 930 APFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAAG 989
+ASV + + AG++ R IE G G P +G
Sbjct: 883 DLTASSAQASVLKMLQA-ARDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSG 941
Query: 990 RPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGF----PSPPAPPAAAATAVGPPL 1045
P PP +P P+ + PP G P PP P GPPL
Sbjct: 942 PSPCLPTPDPPPEPSPTGWG---------PPDGGRAALVRRAPQPPGRPPTP----GPPL 988
Query: 1046 CRLAFEDESPPAPARWP 1062
++ P ARWP
Sbjct: 989 SDVSRVSRRPAWEARWP 1005
Score = 34.3 bits (77), Expect = 0.82
Identities = 71/246 (28%), Positives = 90/246 (36%), Gaps = 37/246 (15%)
Query: 1086 GGGAPAAPP-PC---RAAPPPC-PYLDLEPSPSDSEDSESLGG-ASLGGLEPWWFADFPY 1139
GGG A PP PC R+ P PC P D P PS + GG A+L P P
Sbjct: 924 GGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGRPPT 983
Query: 1140 PYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHC-RHCASLEL-LPPPR--HL 1195
P GPP V + W A W P R+G HC RH ++ E L P R +
Sbjct: 984 P-----GPPLSDVSRVSRRPAWEA-RW---PVRTG----HCGRHLSASERPLSPARCHYS 1030
Query: 1196 SCSHDGLDGGWWAPPPPPWAAGP------LPRRRARCGCPRSHPHRPRASHRTPAAAAPH 1249
S G + P P P L RR A + RPR + P++ A
Sbjct: 1031 SFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA-SLPSSVAEA 1089
Query: 1250 HHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPT 1309
R G P + S+C R A A+ + P + C G P
Sbjct: 1090 FARPSSLPAGC----TGPACARPDGHSACRRLAQAQSMCLPI-YREACQEGEQAG--APA 1142
Query: 1310 ASHRRH 1315
HR+H
Sbjct: 1143 WQHRQH 1148
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 976 bits (2522), Expect = 0.0
Identities = 489/872 (56%), Positives = 617/872 (70%), Gaps = 39/872 (4%)
Query: 51 LNVALVFSGPAYAAEAARLGPAVAAAV--------------------RSPGL--DVRPVA 88
L LV+ GPA +A A + PA+ AV ++ GL DV VA
Sbjct: 12 LPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVA 71
Query: 89 LVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGA 148
L++N +DP+SL+ +CDL+SG R+HG+VF DD+ AVA +LDF+S+ T +PI+ +HGGA
Sbjct: 72 LLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGA 131
Query: 149 ALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLT 208
++++ K+ STF Q G+S +QQ V+ +++++YDW F VTT PG+R F+S+++
Sbjct: 132 SMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTV 191
Query: 209 DGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGS 268
D S VGW+ + +TLD +A QL+ + + + LL+C+++EA + A GLTG
Sbjct: 192 DNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGY 251
Query: 269 GYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVA 328
+ W + P L G P E P+GL +V W L RV G+ ++
Sbjct: 252 DFFWIV--PSLVSGNTELIPKE---------FPSGLISVSYDDWDYSLEARVRDGIGILT 300
Query: 329 RGAQALLRDYGFLPELGHDCRAQNRTHRG--ESLHRYFMNITWDNRDYSFNEDGFLVNPS 386
A ++L + ++PE C Q +LH + +N+TWD +D SF E+G+ V+P
Sbjct: 301 TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR 360
Query: 387 LVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVE 446
LVVI L +DR WE VG WE TL L++ +W RY F D HL++ TLEE PFVIVE
Sbjct: 361 LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE 420
Query: 447 PADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLY 506
DP++ TC+R++VPCR + +S + K+CCKGFCIDILK+L+ T+ F+YDLY
Sbjct: 421 DIDPLTETCVRNTVPCRKFVKINNST--NEGMNVKKCCKGFCIDILKKLSRTVKFTYDLY 478
Query: 507 LVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVA 566
LVTNGKHGKK++ VWNGMIGEV YQRA MA+GSLTINEERSE+VDFSVPFVETGISVMV+
Sbjct: 479 LVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVS 538
Query: 567 RSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGST 626
RSNGTVSPSAFLEP+S +VWVMMFVM L V A+ VF+FEY SPVGYNR+LA GK P G +
Sbjct: 539 RSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPS 598
Query: 627 FTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEY 686
FTIGK+IWLLW LVFNNSVPV+NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQEE+
Sbjct: 599 FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEF 658
Query: 687 VDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALT 746
VD V+GLSD+KFQRP + PP +FGTVPNGSTE+NIR+NYP MH YM ++NQ VE+AL
Sbjct: 659 VDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALV 718
Query: 747 QLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLA 806
LK GKLDAFIYDAAVLNY A +DEGCKLVTIGSG +FATTGYGIAL KGS WKR IDLA
Sbjct: 719 SLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLA 778
Query: 807 LLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 866
LLQF+GD E+E LE LWL+GICHN+K EVMSS+LDIDNMAGVFYML AM LSL+ F WE
Sbjct: 779 LLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWE 838
Query: 867 HLVYWRLRHCLGP--THRMDFLLAFSRGMYSC 896
HL YW+LR C + R L + SRG+YSC
Sbjct: 839 HLFYWKLRFCFTGVCSDRPGLLFSISRGIYSC 870
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 976 bits (2522), Expect = 0.0
Identities = 489/872 (56%), Positives = 617/872 (70%), Gaps = 39/872 (4%)
Query: 51 LNVALVFSGPAYAAEAARLGPAVAAAV--------------------RSPGL--DVRPVA 88
L LV+ GPA +A A + PA+ AV ++ GL DV VA
Sbjct: 12 LPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVA 71
Query: 89 LVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGA 148
L++N +DP+SL+ +CDL+SG R+HG+VF DD+ AVA +LDF+S+ T +PI+ +HGGA
Sbjct: 72 LLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGA 131
Query: 149 ALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLT 208
++++ K+ STF Q G+S +QQ V+ +++++YDW F VTT PG+R F+S+++
Sbjct: 132 SMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTV 191
Query: 209 DGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGS 268
D S VGW+ + +TLD +A QL+ + + + LL+C+++EA + A GLTG
Sbjct: 192 DNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGY 251
Query: 269 GYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVA 328
+ W + P L G P E P+GL +V W L RV G+ ++
Sbjct: 252 DFFWIV--PSLVSGNTELIPKE---------FPSGLISVSYDDWDYSLEARVRDGIGILT 300
Query: 329 RGAQALLRDYGFLPELGHDCRAQNRTHRG--ESLHRYFMNITWDNRDYSFNEDGFLVNPS 386
A ++L + ++PE C Q +LH + +N+TWD +D SF E+G+ V+P
Sbjct: 301 TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR 360
Query: 387 LVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVE 446
LVVI L +DR WE VG WE TL L++ +W RY F D HL++ TLEE PFVIVE
Sbjct: 361 LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE 420
Query: 447 PADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLY 506
DP++ TC+R++VPCR + +S + K+CCKGFCIDILK+L+ T+ F+YDLY
Sbjct: 421 DIDPLTETCVRNTVPCRKFVKINNST--NEGMNVKKCCKGFCIDILKKLSRTVKFTYDLY 478
Query: 507 LVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVA 566
LVTNGKHGKK++ VWNGMIGEV YQRA MA+GSLTINEERSE+VDFSVPFVETGISVMV+
Sbjct: 479 LVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVS 538
Query: 567 RSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGST 626
RSNGTVSPSAFLEP+S +VWVMMFVM L V A+ VF+FEY SPVGYNR+LA GK P G +
Sbjct: 539 RSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPS 598
Query: 627 FTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEY 686
FTIGK+IWLLW LVFNNSVPV+NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQEE+
Sbjct: 599 FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEF 658
Query: 687 VDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALT 746
VD V+GLSD+KFQRP + PP +FGTVPNGSTE+NIR+NYP MH YM ++NQ VE+AL
Sbjct: 659 VDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALV 718
Query: 747 QLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLA 806
LK GKLDAFIYDAAVLNY A +DEGCKLVTIGSG +FATTGYGIAL KGS WKR IDLA
Sbjct: 719 SLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLA 778
Query: 807 LLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 866
LLQF+GD E+E LE LWL+GICHN+K EVMSS+LDIDNMAGVFYML AM LSL+ F WE
Sbjct: 779 LLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWE 838
Query: 867 HLVYWRLRHCLGP--THRMDFLLAFSRGMYSC 896
HL YW+LR C + R L + SRG+YSC
Sbjct: 839 HLFYWKLRFCFTGVCSDRPGLLFSISRGIYSC 870
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 976 bits (2522), Expect = 0.0
Identities = 489/872 (56%), Positives = 617/872 (70%), Gaps = 39/872 (4%)
Query: 51 LNVALVFSGPAYAAEAARLGPAVAAAV--------------------RSPGL--DVRPVA 88
L LV+ GPA +A A + PA+ AV ++ GL DV VA
Sbjct: 12 LPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVA 71
Query: 89 LVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGA 148
L++N +DP+SL+ +CDL+SG R+HG+VF DD+ AVA +LDF+S+ T +PI+ +HGGA
Sbjct: 72 LLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGA 131
Query: 149 ALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLT 208
++++ K+ STF Q G+S +QQ V+ +++++YDW F VTT PG+R F+S+++
Sbjct: 132 SMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTV 191
Query: 209 DGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGS 268
D S VGW+ + +TLD +A QL+ + + + LL+C+++EA + A GLTG
Sbjct: 192 DNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGY 251
Query: 269 GYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVA 328
+ W + P L G P E P+GL +V W L RV G+ ++
Sbjct: 252 DFFWIV--PSLVSGNTELIPKE---------FPSGLISVSYDDWDYSLEARVRDGIGILT 300
Query: 329 RGAQALLRDYGFLPELGHDCRAQNRTHRG--ESLHRYFMNITWDNRDYSFNEDGFLVNPS 386
A ++L + ++PE C Q +LH + +N+TWD +D SF E+G+ V+P
Sbjct: 301 TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR 360
Query: 387 LVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVE 446
LVVI L +DR WE VG WE TL L++ +W RY F D HL++ TLEE PFVIVE
Sbjct: 361 LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE 420
Query: 447 PADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLY 506
DP++ TC+R++VPCR + +S + K+CCKGFCIDILK+L+ T+ F+YDLY
Sbjct: 421 DIDPLTETCVRNTVPCRKFVKINNST--NEGMNVKKCCKGFCIDILKKLSRTVKFTYDLY 478
Query: 507 LVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVA 566
LVTNGKHGKK++ VWNGMIGEV YQRA MA+GSLTINEERSE+VDFSVPFVETGISVMV+
Sbjct: 479 LVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVS 538
Query: 567 RSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGST 626
RSNGTVSPSAFLEP+S +VWVMMFVM L V A+ VF+FEY SPVGYNR+LA GK P G +
Sbjct: 539 RSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPS 598
Query: 627 FTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEY 686
FTIGK+IWLLW LVFNNSVPV+NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQEE+
Sbjct: 599 FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEF 658
Query: 687 VDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALT 746
VD V+GLSD+KFQRP + PP +FGTVPNGSTE+NIR+NYP MH YM ++NQ VE+AL
Sbjct: 659 VDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALV 718
Query: 747 QLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLA 806
LK GKLDAFIYDAAVLNY A +DEGCKLVTIGSG +FATTGYGIAL KGS WKR IDLA
Sbjct: 719 SLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLA 778
Query: 807 LLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 866
LLQF+GD E+E LE LWL+GICHN+K EVMSS+LDIDNMAGVFYML AM LSL+ F WE
Sbjct: 779 LLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWE 838
Query: 867 HLVYWRLRHCLGP--THRMDFLLAFSRGMYSC 896
HL YW+LR C + R L + SRG+YSC
Sbjct: 839 HLFYWKLRFCFTGVCSDRPGLLFSISRGIYSC 870
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 938 bits (2425), Expect = 0.0
Identities = 463/814 (56%), Positives = 594/814 (72%), Gaps = 19/814 (2%)
Query: 89 LVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGA 148
+ +N +DP+S++ ++CDL+S ++ GVVF DD+ A+A ILDF+SAQT PI+ +HGG+
Sbjct: 71 VAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGS 130
Query: 149 ALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLT 208
++++ K++ S F Q G S EQQ V+ ++EEYDW F VTT PG++ F++ I
Sbjct: 131 SMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTI 190
Query: 209 DGSLVGWEHRGALTLDPGA--GEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLT 266
+ S VGWE L LD G++ + QL+ + + I LL+C +EEA +F A GLT
Sbjct: 191 ENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLT 250
Query: 267 GSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAV 326
G GY W + P L G P E P GL +V W L RV G+A+
Sbjct: 251 GYGYTWIV--PSLVAGDTDTVPAE---------FPTGLISVSYDEWDYGLPARVRDGIAI 299
Query: 327 VARGAQALLRDYGFLPELGHDC--RAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVN 384
+ A +L ++ F+PE C + R ++ L+RY +N+T++ R+ SF+EDG+ ++
Sbjct: 300 ITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMH 359
Query: 385 PSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVI 444
P LV+I L ++R WE VG W+ ++L++KY +W R + +D HL++ TLEE PFVI
Sbjct: 360 PKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQED-DHLSIVTLEEAPFVI 418
Query: 445 VEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYD 504
VE DP+SGTC+R++VPC+ ++ T + + P K+CCKGFCIDILK+++ ++ F+YD
Sbjct: 419 VESVDPLSGTCMRNTVPCQKRIV-TENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYD 477
Query: 505 LYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVM 564
LYLVTNGKHGKKI+G WNGMIGEV +RA MA+GSLTINEERSE+VDFSVPF+ETGISVM
Sbjct: 478 LYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVM 537
Query: 565 VARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGG 624
V+RSNGTVSPSAFLEP+S VWVMMFVM L V AV VF+FEY SPVGYNR LA G+ PGG
Sbjct: 538 VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGG 597
Query: 625 STFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQE 684
+FTIGK+IWLLW LVFNNSVPV+NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQE
Sbjct: 598 PSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQE 657
Query: 685 EYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEA 744
EYVD VSGLSD+KFQRP + PP +FGTVPNGSTE+NIR+NY +MH+YM ++NQ V++A
Sbjct: 658 EYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDA 717
Query: 745 LTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPID 804
L LK GKLDAFIYDAAVLNYMA +DEGCKLVTIGSGKVFA+TGYGIA+ K S WKR +D
Sbjct: 718 LLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVD 777
Query: 805 LALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFA 864
LA+LQ GD E+E LE LWL+GICHN+K EVMSS+LDIDNMAGVFYML AM LSL+ F
Sbjct: 778 LAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFI 837
Query: 865 WEHLVYWRLRHCLGP--THRMDFLLAFSRGMYSC 896
EHL YW+ RHC + + + + SRG+YSC
Sbjct: 838 CEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSC 871
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 288 bits (737), Expect = 2e-77
Identities = 292/1033 (28%), Positives = 445/1033 (43%), Gaps = 125/1033 (12%)
Query: 32 APGPGGAGG---PGG---GLGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVR 85
A GPG AGG P G LGG+ L L + A A A L A A L +
Sbjct: 14 ALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARAALAPRLPHNLSLE 73
Query: 86 PVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVA-V 144
V DP SL LC L V ++ ++R + L FL+A T P+++ +
Sbjct: 74 LVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQ--LHFLAAATETPVLSLL 131
Query: 145 HGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDW--TSFVAVTTRAPGHRAFLS 202
A L L S E L V+ VL+ + W T+ PG
Sbjct: 132 RREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPG------ 185
Query: 203 YIEVLTDGSLVGWEHRGA----LTLD---PGAGEAVLSAQLRSVSAQIR---------LL 246
G + W R L LD G+A L A+L ++A + LL
Sbjct: 186 -------GLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPAAVLL 238
Query: 247 FCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFA 306
C A V A G W + G P P LP A LP GL A
Sbjct: 239 GCDIARARRVLEAVP------PGPHWLL-----------GTPLPPKALP-TAGLPPGLLA 280
Query: 307 VRSAGWRDDLARRVAAGVAVVAR--GAQALLRDYGFL---PELGHDCRAQNRTHRGESLH 361
+ R L + V +VAR G+ A ++ L P D + G L
Sbjct: 281 LGEVA-RPPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLA 339
Query: 362 RYFMNITWDNRD---YSFNEDGFLVNPSLVVISLTRD----RTWEVVGSWEQQTLRLKYP 414
R+ N ++ R + ++ V SL RD W VGSW L L+
Sbjct: 340 RFLANTSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPG 399
Query: 415 LWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPAD-----PISGTCIRDSVPCRSQLNRT 469
S Q L V TL E PFV D P C+ + L+
Sbjct: 400 GASARPPPPQGAQVWPKLRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDAL 459
Query: 470 HSPPPD--APRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGE 527
+ + APR ++CC G+CID+L+RLA F ++LYLV +GK+G DG W G++G+
Sbjct: 460 FAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGD 519
Query: 528 VFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSP-SAFLEPYSPAVW 586
+ RA MA+ S +IN RS++VDF+ PF T + +MV R+ T SP AF+ P + W
Sbjct: 520 LLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RARDTASPIGAFMWPLHWSTW 578
Query: 587 VMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVP 646
+ +F L + A+ + ++E+ SP G L R + F+ ++ L +A++F +V
Sbjct: 579 LGVFA-ALHLTALFLTVYEWRSPYG----LTPRGRNRSTVFSYSSALNLCYAILFRRTVS 633
Query: 647 VENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYP 706
+ P+ T ++++ +WA F ++ L+SYTANLAA M+ ++ + +SG+ D K P + +
Sbjct: 634 SKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGF- 692
Query: 707 PLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAG--KLDAFIYDAAVLN 764
+FGTV S E I+ ++PDMH++M R++ P + L + KL+AFI D ++L+
Sbjct: 693 --RFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLD 750
Query: 765 YMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL 824
Y D CKL+T+ GK FA GYGI L + S + + ++ I++L W
Sbjct: 751 YEVSIDADCKLLTV--GKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWY 808
Query: 825 SGICHNDKIEVMSS--KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHR 882
+ ++ ++ ++ I + AG+F +L + +G +LL EH + + R
Sbjct: 809 KMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSR 868
Query: 883 MDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVP----RERA 938
+ + L S+ ++ + E PP + PS + P P R R
Sbjct: 869 LQYWLHTSQKIHRALNTE--PPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKRARR 926
Query: 939 SVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRG------AAGRPL 992
+VD+ RR + P + P+ EA AAPR + GR
Sbjct: 927 AVDKERRVRFLLEPAVV------------VAPE----ADAEAEAAPREGPVWLCSYGR-- 968
Query: 993 SPPAAQPPQKPPP 1005
PPAA+P P P
Sbjct: 969 -PPAARPTGAPQP 980
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
3A [Homo sapiens]
Length = 1115
Score = 276 bits (707), Expect = 7e-74
Identities = 176/540 (32%), Positives = 276/540 (51%), Gaps = 39/540 (7%)
Query: 357 GESLHRYFMNITWDNRDYSFNEDGFLVNPS---LVVISLTRDRT----WEVVGSWEQQTL 409
G+ L R+ N T+ S G + S + +L D W +GSW+ +
Sbjct: 430 GQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKI 489
Query: 410 RLKYPLWSRYGR-----FLQPVDDTQHLTVATLEERPFVIVEPAD-----PISGTCI--- 456
+ Y +W + F P HL V TL E PFV D P C+
Sbjct: 490 VMDYGIWPEQAQRHKTHFQHP--SKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPM 547
Query: 457 -RDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGK 515
DS S + HS P K+CC G+CID+L+++A + F +DLY+V +GK+G
Sbjct: 548 TNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGA 607
Query: 516 KIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSP- 574
+G W G++G++ A MA+ S +IN RS+++DF+ PF T + ++V R+ T +P
Sbjct: 608 WKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILV-RTRDTAAPI 666
Query: 575 SAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIW 634
AF+ P +W+ +FV L + AV + ++E+ SP G L R F+ ++
Sbjct: 667 GAFMWPLHWTMWLGIFV-ALHITAVFLTLYEWKSPFG----LTPKGRNRSKVFSFSSALN 721
Query: 635 LLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLS 694
+ +AL+F +V ++ P+ T + ++ +WA F + L++YTANLAA M+ E+ + +SG+
Sbjct: 722 ICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIH 781
Query: 695 DRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLK--AGK 752
D K P + + +FGTV S E +R ++P+MH YM RYN P + + LK K
Sbjct: 782 DPKLHHPSQGF---RFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEK 838
Query: 753 LDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLG 812
LDAFI D A+L+Y D CKL+T+ GK FA GYGI L S I + Q+
Sbjct: 839 LDAFIMDKALLDYEVSIDADCKLLTV--GKPFAIEGYGIGLPPNSPLTANISELISQYKS 896
Query: 813 DDEIEMLERLWLSGI-CHNDKIEVMSS-KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVY 870
++ML W + C V + ++ I + +G+F +L + GLS+L EH+VY
Sbjct: 897 HGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVY 956
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 263 bits (672), Expect = 8e-70
Identities = 196/725 (27%), Positives = 356/725 (49%), Gaps = 52/725 (7%)
Query: 160 TFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRG 219
+FL+ Q V FE++ Y W + + + RA +E L + E
Sbjct: 136 SFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEK-- 193
Query: 220 ALTLDPGAGEAV-LSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQ 278
L DPG L + + + A++ +L + ++A V+RAA +TGSGYVW + +
Sbjct: 194 VLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGERE 253
Query: 279 LAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDY 338
++G AP G+ ++ +++ A ++ V VVA+ LL
Sbjct: 254 ISGNALRYAPD-------------GILGLQLINGKNESAH-ISDAVGVVAQAVHELLEKE 299
Query: 339 GFLPELGHDCRAQNRTHRGESLHRYFMNITWDNR---DYSFNEDGFLVNPSLVVISLTRD 395
N G R M+ + + FNEDG + +++L
Sbjct: 300 NITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNR 359
Query: 396 RTWEV-VGSWEQQTLRLKYPLWSRYGRFLQP--VDDTQHLTVATLEERPFVIVEPADPIS 452
+ +V + + + +W G +P + L + T+ + PFV V+P
Sbjct: 360 KLVQVGIYNGTHVIPNDRKIIWPG-GETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLS-D 417
Query: 453 GTCIRDSVPCRSQLNRT-----HSPPPDAPRPE-KRCCKGFCIDILKRLAHTIGFSYDLY 506
GTC + + + + P +PR +CC GFCID+L +LA T+ F+Y+++
Sbjct: 418 GTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVH 477
Query: 507 LVTNGKHG--KKIDGV----WNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETG 560
LV +GK G ++++ WNGM+GE+ +ADM + LTIN ER++ ++FS PF G
Sbjct: 478 LVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQG 537
Query: 561 ISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGK 620
++++V + + +F++P+ +W+++ + + VVAV +++ + SP G R +
Sbjct: 538 LTILVKKEIPRSTLDSFMQPFQSTLWLLVG-LSVHVVAVMLYLLDRFSPFG--RFKVNSE 594
Query: 621 RPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAF 680
T+ ++W W ++ N+ + PR +++I+ +VWA FA+I +ASYTANLAAF
Sbjct: 595 EEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAF 654
Query: 681 MIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRS--NYPDMHSYMVRYNQ 738
++ + + ++G++D + + P +++ + TV S + R M+ +M ++N
Sbjct: 655 LVLDRPEERITGINDPRLRNPSDKF---IYATVKQSSVDIYFRRQVELSTMYRHMEKHNY 711
Query: 739 PRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSR 798
EA+ ++ KL AFI+D+AVL + A + C LVT +G++F +G+GI + K S
Sbjct: 712 ESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFRSGFGIGMRKDSP 767
Query: 799 WKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGL 858
WK+ + L++L+ + +E L++ W+ D + L +NMAGVF +LVA G+
Sbjct: 768 WKQNVSLSILKSHENGFMEDLDKTWVR-YQECDSRSNAPATLTFENMAGVF--MLVAGGI 824
Query: 859 SLLVF 863
+F
Sbjct: 825 VAGIF 829
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 263 bits (672), Expect = 8e-70
Identities = 196/725 (27%), Positives = 356/725 (49%), Gaps = 52/725 (7%)
Query: 160 TFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRG 219
+FL+ Q V FE++ Y W + + + RA +E L + E
Sbjct: 136 SFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEK-- 193
Query: 220 ALTLDPGAGEAV-LSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQ 278
L DPG L + + + A++ +L + ++A V+RAA +TGSGYVW + +
Sbjct: 194 VLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGERE 253
Query: 279 LAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDY 338
++G AP G+ ++ +++ A ++ V VVA+ LL
Sbjct: 254 ISGNALRYAPD-------------GILGLQLINGKNESAH-ISDAVGVVAQAVHELLEKE 299
Query: 339 GFLPELGHDCRAQNRTHRGESLHRYFMNITWDNR---DYSFNEDGFLVNPSLVVISLTRD 395
N G R M+ + + FNEDG + +++L
Sbjct: 300 NITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNR 359
Query: 396 RTWEV-VGSWEQQTLRLKYPLWSRYGRFLQP--VDDTQHLTVATLEERPFVIVEPADPIS 452
+ +V + + + +W G +P + L + T+ + PFV V+P
Sbjct: 360 KLVQVGIYNGTHVIPNDRKIIWPG-GETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLS-D 417
Query: 453 GTCIRDSVPCRSQLNRT-----HSPPPDAPRPE-KRCCKGFCIDILKRLAHTIGFSYDLY 506
GTC + + + + P +PR +CC GFCID+L +LA T+ F+Y+++
Sbjct: 418 GTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVH 477
Query: 507 LVTNGKHG--KKIDGV----WNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETG 560
LV +GK G ++++ WNGM+GE+ +ADM + LTIN ER++ ++FS PF G
Sbjct: 478 LVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQG 537
Query: 561 ISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGK 620
++++V + + +F++P+ +W+++ + + VVAV +++ + SP G R +
Sbjct: 538 LTILVKKEIPRSTLDSFMQPFQSTLWLLVG-LSVHVVAVMLYLLDRFSPFG--RFKVNSE 594
Query: 621 RPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAF 680
T+ ++W W ++ N+ + PR +++I+ +VWA FA+I +ASYTANLAAF
Sbjct: 595 EEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAF 654
Query: 681 MIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRS--NYPDMHSYMVRYNQ 738
++ + + ++G++D + + P +++ + TV S + R M+ +M ++N
Sbjct: 655 LVLDRPEERITGINDPRLRNPSDKF---IYATVKQSSVDIYFRRQVELSTMYRHMEKHNY 711
Query: 739 PRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSR 798
EA+ ++ KL AFI+D+AVL + A + C LVT +G++F +G+GI + K S
Sbjct: 712 ESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFRSGFGIGMRKDSP 767
Query: 799 WKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGL 858
WK+ + L++L+ + +E L++ W+ D + L +NMAGVF +LVA G+
Sbjct: 768 WKQNVSLSILKSHENGFMEDLDKTWVR-YQECDSRSNAPATLTFENMAGVF--MLVAGGI 824
Query: 859 SLLVF 863
+F
Sbjct: 825 VAGIF 829
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 263 bits (672), Expect = 8e-70
Identities = 196/725 (27%), Positives = 356/725 (49%), Gaps = 52/725 (7%)
Query: 160 TFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRG 219
+FL+ Q V FE++ Y W + + + RA +E L + E
Sbjct: 136 SFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEK-- 193
Query: 220 ALTLDPGAGEAV-LSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQ 278
L DPG L + + + A++ +L + ++A V+RAA +TGSGYVW + +
Sbjct: 194 VLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGERE 253
Query: 279 LAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDY 338
++G AP G+ ++ +++ A ++ V VVA+ LL
Sbjct: 254 ISGNALRYAPD-------------GILGLQLINGKNESAH-ISDAVGVVAQAVHELLEKE 299
Query: 339 GFLPELGHDCRAQNRTHRGESLHRYFMNITWDNR---DYSFNEDGFLVNPSLVVISLTRD 395
N G R M+ + + FNEDG + +++L
Sbjct: 300 NITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNR 359
Query: 396 RTWEV-VGSWEQQTLRLKYPLWSRYGRFLQP--VDDTQHLTVATLEERPFVIVEPADPIS 452
+ +V + + + +W G +P + L + T+ + PFV V+P
Sbjct: 360 KLVQVGIYNGTHVIPNDRKIIWPG-GETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLS-D 417
Query: 453 GTCIRDSVPCRSQLNRT-----HSPPPDAPRPE-KRCCKGFCIDILKRLAHTIGFSYDLY 506
GTC + + + + P +PR +CC GFCID+L +LA T+ F+Y+++
Sbjct: 418 GTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVH 477
Query: 507 LVTNGKHG--KKIDGV----WNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETG 560
LV +GK G ++++ WNGM+GE+ +ADM + LTIN ER++ ++FS PF G
Sbjct: 478 LVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQG 537
Query: 561 ISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGK 620
++++V + + +F++P+ +W+++ + + VVAV +++ + SP G R +
Sbjct: 538 LTILVKKEIPRSTLDSFMQPFQSTLWLLVG-LSVHVVAVMLYLLDRFSPFG--RFKVNSE 594
Query: 621 RPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAF 680
T+ ++W W ++ N+ + PR +++I+ +VWA FA+I +ASYTANLAAF
Sbjct: 595 EEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAF 654
Query: 681 MIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRS--NYPDMHSYMVRYNQ 738
++ + + ++G++D + + P +++ + TV S + R M+ +M ++N
Sbjct: 655 LVLDRPEERITGINDPRLRNPSDKF---IYATVKQSSVDIYFRRQVELSTMYRHMEKHNY 711
Query: 739 PRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSR 798
EA+ ++ KL AFI+D+AVL + A + C LVT +G++F +G+GI + K S
Sbjct: 712 ESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFRSGFGIGMRKDSP 767
Query: 799 WKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGL 858
WK+ + L++L+ + +E L++ W+ D + L +NMAGVF +LVA G+
Sbjct: 768 WKQNVSLSILKSHENGFMEDLDKTWVR-YQECDSRSNAPATLTFENMAGVF--MLVAGGI 824
Query: 859 SLLVF 863
+F
Sbjct: 825 VAGIF 829
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 186 bits (472), Expect = 1e-46
Identities = 220/901 (24%), Positives = 378/901 (41%), Gaps = 122/901 (13%)
Query: 13 PAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLGPA 72
PA++LLLL +A ASP + L +A + RL A
Sbjct: 2 PAELLLLLIVAFASPSCQVLSS----------------LRMAAILDDQTVCGRGERLALA 45
Query: 73 VAAAVRSPGLDVRPVALVLNG--SDPRSLVLQLCDLLSGLRVHGVVFE-DDSRAPAVAPI 129
+A + ++V A V R + D + + GVV S +PA A
Sbjct: 46 LAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASAST 105
Query: 130 LDFLSAQTSLPIVAVHGGAALVLTPKEKGSTF--LQLGSSTEQQLQVIFEVLEEYDWTSF 187
+ + + +P + V TP+ + F + L S E + +L+ +++ S
Sbjct: 106 VSHICGEKEIPHIKVGPEE----TPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSA 161
Query: 188 VAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLF 247
+ +A L +E L G L+ E LD L ++R ++
Sbjct: 162 SLICAKAE----CLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIID 217
Query: 248 CAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGA------PLP 301
+ + R A E G+T + Y + + G + + G + P
Sbjct: 218 ANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFY 277
Query: 302 AGLFAVRSAGWRDDLARRVAAGVAVVA-------RGAQALLRDYGFLPELGHD---CRAQ 351
+ WR++ G A+ A + +R+ E+G C +
Sbjct: 278 PEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSA 337
Query: 352 NRTHRGESLHRYFMNITWDNRD--YSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTL 409
N G SL Y + +D FN G N +L ++ +R E+ + +TL
Sbjct: 338 NIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTL 397
Query: 410 RLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPA-DPISGTCIRDSVPCRSQLNR 468
+ + L + L V T+ E P+V+ P +SG
Sbjct: 398 AMNA---TTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGN-------------- 440
Query: 469 THSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGK-KIDGVWNGMIGE 527
+GFC+D+L+ LA + F Y L LV +G +G + +G W GM+GE
Sbjct: 441 -------------ERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGE 487
Query: 528 VFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVM----VARSNGTVSPSAFLEPYSP 583
+ ++AD+A+ + TI ER +++DFS PF+ GIS++ + R G S FL+P+SP
Sbjct: 488 LINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSP 544
Query: 584 AVWVMMFVMCLTVVAVTVFIFEYLSPV-GYNRSLATGKRPG--GSTFTIGKSIWLLWALV 640
AVW+ M + L V V +F+ LSP YN RP + +T+G S+W
Sbjct: 545 AVWLFMLLAYLAVSCV-LFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGF 603
Query: 641 FNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMI---QEEYVDTVSGLSDRK 697
+ PR +++ + VW F +I ++SYTANLAAF+ E V++ L+D+
Sbjct: 604 MQQGSEI-MPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQ- 661
Query: 698 FQRPQEQYPPLKFGTVPNGST----EKNIRSNYPDMHSYMVRYNQPRV-----EEALTQL 748
+++GT+ GST + + Y M +YM + QP V EE + ++
Sbjct: 662 --------TNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYM-QSKQPSVFVKSTEEGIARV 712
Query: 749 KAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALL 808
+ AF+ ++ + Y R + C L IG + T GYGI + GS ++ I LA+L
Sbjct: 713 LNSRY-AFLLESTMNEYHRRLN--CNLTQIGG--LLDTKGYGIGMPLGSPFRDEITLAIL 767
Query: 809 QFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYM----LLVAMGLSLLVFA 864
Q ++ +E+L+R W G + + + L ++N+ G+F + L++A+ ++++ F
Sbjct: 768 QLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFI 827
Query: 865 W 865
W
Sbjct: 828 W 828
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 185 bits (469), Expect = 3e-46
Identities = 125/400 (31%), Positives = 211/400 (52%), Gaps = 38/400 (9%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID-GVWNGMIGEVFYQRADMAIGSLTIN 543
+G+CID+LK LAH +GFSY++ LV +GK+G + D G WNGM+ E+ +AD+A+ LTI
Sbjct: 463 EGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTIT 522
Query: 544 EERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTV 601
R + +DFS PF+ G+S++ + NGT +PS +FL P SP +W+ + + L V V +
Sbjct: 523 HVREKAIDFSKPFMTLGVSILYRKPNGT-NPSVFSFLNPLSPDIWMYVLLAYLGVSCV-L 580
Query: 602 FIFEYLSPVGYNRSLATGKRPGG----STFTIGKSIWLLWALVFNNSVPVENPRGTTSKI 657
F+ SP Y A PG + FT+ S W + + P+ +++I
Sbjct: 581 FVIARFSP--YEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSEL-MPKALSTRI 637
Query: 658 MVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGS 717
+ +W FF +I ++SYTANLAAF+ E + D Q +++G V +G+
Sbjct: 638 IGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TKIEYGAVKDGA 691
Query: 718 T----EKNIRSNYPDMHSYM-------VRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYM 766
T +K+ S + M ++M V+ N+ ++ ALT A + ++ + Y+
Sbjct: 692 TMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADY-----ALLMESTTIEYV 746
Query: 767 ARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSG 826
+++ C L IG + + GYGI GS ++ I +A+LQ +D++ +++ W G
Sbjct: 747 TQRN--CNLTQIGG--LIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRG 802
Query: 827 ICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 866
++ +S L I + G+F +L + LS+LV E
Sbjct: 803 SGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGE 842
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 179 bits (454), Expect = 2e-44
Identities = 134/462 (29%), Positives = 234/462 (50%), Gaps = 55/462 (11%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHG-KKIDGVWNGMIGEVFYQRADMAIGSLTIN 543
+GFC+D+LK LA + F+Y + LV +G +G + +G W GM+GE+ ++AD+A+ LTI
Sbjct: 445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTIT 504
Query: 544 EERSEIVDFSVPFVETGISVM----VARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAV 599
ER +++DFS PF+ GIS++ + R G S FL+P+SP VW+ M + L V V
Sbjct: 505 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPGVWLFMLLAYLAVSCV 561
Query: 600 TVFI-----FEYLSPVGYNRSLATGK-RPGGSTFTIGKSIWLLWALVFNNSVPVENPRGT 653
+ +E+ SP A G+ + +++G S+W + PR
Sbjct: 562 LFLVARLTPYEWYSP----HPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIA-PRAL 616
Query: 654 TSKIMVLVWAFFAVIFLASYTANLAAFMIQEEY---VDTVSGLSDRKFQRPQEQYPPLKF 710
+++ + VW F +I ++SYTANLAAF+ + +++V L+D+ +++
Sbjct: 617 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQ---------TAIEY 667
Query: 711 GTVPNGST----EKNIRSNYPDMHSYMVRYNQPRV-----EEALTQLKAGKLDAFIYDAA 761
GT+ GS+ + + Y M +YM QP V EE + ++ AF+ ++
Sbjct: 668 GTIHGGSSMTFFQNSRYQTYQRMWNYMYS-KQPSVFVKSTEEGIARVLNSNY-AFLLEST 725
Query: 762 VLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLER 821
+ Y +++ C L IG + T GYGI + GS ++ DLA+LQ ++ +E+L+R
Sbjct: 726 MNEYYRQRN--CNLTQIGG--LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKR 781
Query: 822 LWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTH 881
W G + + + L ++N+ G+F +L+ + +++ + E L W LRH
Sbjct: 782 KWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL--WTLRHSEATEV 839
Query: 882 RM-DFLLAFSRGMYSCCSA------EAAPPPAKPPPPPQPLP 916
+ ++ R + C + AA PP +PP P + P
Sbjct: 840 SVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRP 881
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 179 bits (454), Expect = 2e-44
Identities = 153/570 (26%), Positives = 267/570 (46%), Gaps = 72/570 (12%)
Query: 323 GVAVVARGAQALLRDYGFLPELGH--DCRAQNRTHRGESL--HRYFMNITWDNR--DYSF 376
GV V+A Q+L R + G+ DC A G+ + R + ++ + F
Sbjct: 296 GVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQF 355
Query: 377 NEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVAT 436
NE G N +L VI + D ++ G W + + ++ G V + ++
Sbjct: 356 NEKGRRTNYTLHVIEMKHDGIRKI-GYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTI 414
Query: 437 LEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLA 496
LE+ ++ + A+ G R E G+C+++ +A
Sbjct: 415 LEDPYVMLKKNANQFEGN----------------------DRYE-----GYCVELAAEIA 447
Query: 497 HTIGFSYDLYLVTNGKHGKKIDGV--WNGMIGEVFYQRADMAIGSLTINEERSEIVDFSV 554
+G+SY L +V++GK+G + WNGM+GE+ Y RAD+A+ LTI R E++DFS
Sbjct: 448 KHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSK 507
Query: 555 PFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYN 613
PF+ GIS+M+ + +FL+P + +W M V V+V +F+ SP ++
Sbjct: 508 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWH 566
Query: 614 -------RSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFA 666
R T + + F I S+W + +PR + +I+ VW FF
Sbjct: 567 SEEFEEGRDQTTSDQ--SNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFT 623
Query: 667 VIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSN- 725
+I ++SYTANLAAF+ E V + D Q + +GT+ GST++ R +
Sbjct: 624 LIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLEAGSTKEFFRRSK 677
Query: 726 ---YPDMHSYMVRYNQPRV-----EEALTQLKAGK-LDAFIYDAAVLNYMARKDEGCKLV 776
+ M +YM + +P V EE + +++ K A++ ++ + Y+ ++ + C +
Sbjct: 678 IAVFEKMWTYM-KSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQR-KPCDTM 735
Query: 777 TIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL--SGIC--HNDK 832
+G + GYGIA KGS + P++LA+L+ ++ L+ W G C +
Sbjct: 736 KVGGN--LDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSG 793
Query: 833 IEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 862
+ +S L + N+AGVFY+L+ +GL++LV
Sbjct: 794 SKDKTSALSLSNVAGVFYILIGGLGLAMLV 823
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 179 bits (454), Expect = 2e-44
Identities = 153/570 (26%), Positives = 267/570 (46%), Gaps = 72/570 (12%)
Query: 323 GVAVVARGAQALLRDYGFLPELGH--DCRAQNRTHRGESL--HRYFMNITWDNR--DYSF 376
GV V+A Q+L R + G+ DC A G+ + R + ++ + F
Sbjct: 296 GVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQF 355
Query: 377 NEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVAT 436
NE G N +L VI + D ++ G W + + ++ G V + ++
Sbjct: 356 NEKGRRTNYTLHVIEMKHDGIRKI-GYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTI 414
Query: 437 LEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLA 496
LE+ ++ + A+ G R E G+C+++ +A
Sbjct: 415 LEDPYVMLKKNANQFEGN----------------------DRYE-----GYCVELAAEIA 447
Query: 497 HTIGFSYDLYLVTNGKHGKKIDGV--WNGMIGEVFYQRADMAIGSLTINEERSEIVDFSV 554
+G+SY L +V++GK+G + WNGM+GE+ Y RAD+A+ LTI R E++DFS
Sbjct: 448 KHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSK 507
Query: 555 PFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYN 613
PF+ GIS+M+ + +FL+P + +W M V V+V +F+ SP ++
Sbjct: 508 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWH 566
Query: 614 -------RSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFA 666
R T + + F I S+W + +PR + +I+ VW FF
Sbjct: 567 SEEFEEGRDQTTSDQ--SNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFT 623
Query: 667 VIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSN- 725
+I ++SYTANLAAF+ E V + D Q + +GT+ GST++ R +
Sbjct: 624 LIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLEAGSTKEFFRRSK 677
Query: 726 ---YPDMHSYMVRYNQPRV-----EEALTQLKAGK-LDAFIYDAAVLNYMARKDEGCKLV 776
+ M +YM + +P V EE + +++ K A++ ++ + Y+ ++ + C +
Sbjct: 678 IAVFEKMWTYM-KSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQR-KPCDTM 735
Query: 777 TIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL--SGICHN--DK 832
+G + GYGIA KGS + P++LA+L+ ++ L+ W G C +
Sbjct: 736 KVGGN--LDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGD 793
Query: 833 IEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 862
+ +S L + N+AGVFY+L+ +GL++LV
Sbjct: 794 SKDKTSALSLSNVAGVFYILIGGLGLAMLV 823
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 179 bits (453), Expect = 2e-44
Identities = 122/401 (30%), Positives = 209/401 (52%), Gaps = 35/401 (8%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID-GVWNGMIGEVFYQRADMAIGSLTIN 543
+G+C+D+LK L++ +GF YD+ LV +GK+G + D G WNGM+ E+ RAD+A+ LTI
Sbjct: 461 EGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTIT 520
Query: 544 EERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTV 601
R +++DFS PF+ GIS++ + NGT +P +FL P SP +W+ + + CL V V
Sbjct: 521 YVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCVLF 579
Query: 602 FIFEYLSPVGYN-RSLATGKRPGGSTFTIGKSIWL-LWALVFNNSVPVENPRGTTSKIMV 659
I + YN + FT+ S W + AL+ S + P+ +++I+
Sbjct: 580 VIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM--PKALSTRIVG 637
Query: 660 LVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGST- 718
+W FF +I ++SYTANLAAF+ E + D Q +++G V +GST
Sbjct: 638 GIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TKIEYGAVRDGSTM 691
Query: 719 ---EKNIRSNYPDMHSYM--------VRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMA 767
+K+ S Y M ++M VR + ++ LT A + ++ + Y+
Sbjct: 692 TFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY-----ALLMESTSIEYVT 746
Query: 768 RKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGI 827
+++ C L IG + + GYG+ GS ++ I +A+LQ + ++ M++ W G
Sbjct: 747 QRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN 802
Query: 828 CHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL 868
++ +S L ++N+ G+F +L + LS+ V E +
Sbjct: 803 GCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFI 843
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 179 bits (453), Expect = 2e-44
Identities = 122/401 (30%), Positives = 209/401 (52%), Gaps = 35/401 (8%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID-GVWNGMIGEVFYQRADMAIGSLTIN 543
+G+C+D+LK L++ +GF YD+ LV +GK+G + D G WNGM+ E+ RAD+A+ LTI
Sbjct: 476 EGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTIT 535
Query: 544 EERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTV 601
R +++DFS PF+ GIS++ + NGT +P +FL P SP +W+ + + CL V V
Sbjct: 536 YVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCVLF 594
Query: 602 FIFEYLSPVGYN-RSLATGKRPGGSTFTIGKSIWL-LWALVFNNSVPVENPRGTTSKIMV 659
I + YN + FT+ S W + AL+ S + P+ +++I+
Sbjct: 595 VIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM--PKALSTRIVG 652
Query: 660 LVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGST- 718
+W FF +I ++SYTANLAAF+ E + D Q +++G V +GST
Sbjct: 653 GIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TKIEYGAVRDGSTM 706
Query: 719 ---EKNIRSNYPDMHSYM--------VRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMA 767
+K+ S Y M ++M VR + ++ LT A + ++ + Y+
Sbjct: 707 TFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY-----ALLMESTSIEYVT 761
Query: 768 RKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGI 827
+++ C L IG + + GYG+ GS ++ I +A+LQ + ++ M++ W G
Sbjct: 762 QRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN 817
Query: 828 CHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL 868
++ +S L ++N+ G+F +L + LS+ V E +
Sbjct: 818 GCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFI 858
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 175 bits (444), Expect = 2e-43
Identities = 121/400 (30%), Positives = 206/400 (51%), Gaps = 34/400 (8%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDG--VWNGMIGEVFYQRADMAIGSLTI 542
+G+C+D+ +A GF Y L +V +GK+G + +WNGM+GE+ Y +AD+AI LTI
Sbjct: 396 EGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTI 455
Query: 543 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTV 601
R E++DFS PF+ GIS+M+ + +FL+P + +W M V V+V +
Sbjct: 456 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 514
Query: 602 FIFEYLSPVGYNR-----SLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSK 656
F+ SP ++ T + F I S+W + +PR + +
Sbjct: 515 FLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDI-SPRSLSGR 573
Query: 657 IMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNG 716
I+ VW FF +I ++SYTANLAAF+ E V + D Q + +GT+ +G
Sbjct: 574 IVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQ------TEIAYGTLDSG 627
Query: 717 STEKNIRSN----YPDMHSYMVRYNQPRV-----EEALTQLKAGK-LDAFIYDAAVLNYM 766
ST++ R + + M +YM R +P V E + +++ K A++ ++ + Y+
Sbjct: 628 STKEFFRRSKIAVFDKMWTYM-RSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI 686
Query: 767 ARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL-- 824
++ + C + +G + GYGIA KGS + P++LA+L+ ++ L+ W
Sbjct: 687 EQR-KPCDTMKVGGN--LDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYD 743
Query: 825 SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 862
G C + + +S L + N+AGVFY+L+ +GL++LV
Sbjct: 744 KGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLV 783
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 175 bits (444), Expect = 2e-43
Identities = 121/400 (30%), Positives = 206/400 (51%), Gaps = 34/400 (8%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDG--VWNGMIGEVFYQRADMAIGSLTI 542
+G+C+D+ +A GF Y L +V +GK+G + +WNGM+GE+ Y +AD+AI LTI
Sbjct: 443 EGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTI 502
Query: 543 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTV 601
R E++DFS PF+ GIS+M+ + +FL+P + +W M V V+V +
Sbjct: 503 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 561
Query: 602 FIFEYLSPVGYNR-----SLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSK 656
F+ SP ++ T + F I S+W + +PR + +
Sbjct: 562 FLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDI-SPRSLSGR 620
Query: 657 IMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNG 716
I+ VW FF +I ++SYTANLAAF+ E V + D Q + +GT+ +G
Sbjct: 621 IVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQ------TEIAYGTLDSG 674
Query: 717 STEKNIRSN----YPDMHSYMVRYNQPRV-----EEALTQLKAGK-LDAFIYDAAVLNYM 766
ST++ R + + M +YM R +P V E + +++ K A++ ++ + Y+
Sbjct: 675 STKEFFRRSKIAVFDKMWTYM-RSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI 733
Query: 767 ARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL-- 824
++ + C + +G + GYGIA KGS + P++LA+L+ ++ L+ W
Sbjct: 734 EQR-KPCDTMKVGGN--LDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYD 790
Query: 825 SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 862
G C + + +S L + N+AGVFY+L+ +GL++LV
Sbjct: 791 KGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLV 830
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 174 bits (442), Expect = 4e-43
Identities = 135/473 (28%), Positives = 230/473 (48%), Gaps = 54/473 (11%)
Query: 432 LTVATLEERPFVIVEPADPISG-----------TCIRDSVPCRSQLNRTHSPPP------ 474
L V +L+E + DP SG I DS+ RS + T P
Sbjct: 389 LDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKK 448
Query: 475 -DAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID--GVWNGMIGEVFYQ 531
D P +G+CID+L+ L+ +GF+Y++ LV +GK+G + D G WNGM+ E+
Sbjct: 449 SDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDH 508
Query: 532 RADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMM 589
+AD+A+ L I R +++DFS PF+ GIS++ + NGT +P +FL P SP +W+ +
Sbjct: 509 KADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYI 567
Query: 590 FVMCLTVVAVTVFIFEYLSPVGYN-RSLATGKRPGGSTFTIGKSIWL-LWALVFNNSVPV 647
+ L V V I + YN + FT+ S W + AL+ S +
Sbjct: 568 LLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM 627
Query: 648 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPP 707
P+ +++I+ +W FF +I ++SYTANLAAF+ E + D Q
Sbjct: 628 --PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TK 679
Query: 708 LKFGTVPNGST----EKNIRSNYPDMHSYM--------VRYNQPRVEEALTQLKAGKLDA 755
+++G V +G+T +K+ S Y M ++M V+ N+ ++ LT A
Sbjct: 680 IEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----A 734
Query: 756 FIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDE 815
F+ ++ + ++ +++ C L IG + + GYG+ GS ++ I +A+LQ + +
Sbjct: 735 FLMESTTIEFVTQRN--CNLTQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGK 790
Query: 816 IEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL 868
+ M++ W G ++ +S L + N+ G+F +L + LS+ V E L
Sbjct: 791 LHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 843
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 174 bits (442), Expect = 4e-43
Identities = 135/473 (28%), Positives = 230/473 (48%), Gaps = 54/473 (11%)
Query: 432 LTVATLEERPFVIVEPADPISG-----------TCIRDSVPCRSQLNRTHSPPP------ 474
L V +L+E + DP SG I DS+ RS + T P
Sbjct: 389 LDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKK 448
Query: 475 -DAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID--GVWNGMIGEVFYQ 531
D P +G+CID+L+ L+ +GF+Y++ LV +GK+G + D G WNGM+ E+
Sbjct: 449 SDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDH 508
Query: 532 RADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMM 589
+AD+A+ L I R +++DFS PF+ GIS++ + NGT +P +FL P SP +W+ +
Sbjct: 509 KADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYI 567
Query: 590 FVMCLTVVAVTVFIFEYLSPVGYN-RSLATGKRPGGSTFTIGKSIWL-LWALVFNNSVPV 647
+ L V V I + YN + FT+ S W + AL+ S +
Sbjct: 568 LLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM 627
Query: 648 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPP 707
P+ +++I+ +W FF +I ++SYTANLAAF+ E + D Q
Sbjct: 628 --PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TK 679
Query: 708 LKFGTVPNGST----EKNIRSNYPDMHSYM--------VRYNQPRVEEALTQLKAGKLDA 755
+++G V +G+T +K+ S Y M ++M V+ N+ ++ LT A
Sbjct: 680 IEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----A 734
Query: 756 FIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDE 815
F+ ++ + ++ +++ C L IG + + GYG+ GS ++ I +A+LQ + +
Sbjct: 735 FLMESTTIEFVTQRN--CNLTQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGK 790
Query: 816 IEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL 868
+ M++ W G ++ +S L + N+ G+F +L + LS+ V E L
Sbjct: 791 LHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 843
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 174 bits (441), Expect = 5e-43
Identities = 121/400 (30%), Positives = 206/400 (51%), Gaps = 34/400 (8%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDG--VWNGMIGEVFYQRADMAIGSLTI 542
+G+C+D+ +A IG Y + +V +GK+G + +WNGM+GE+ Y +A++AI LTI
Sbjct: 444 EGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTI 503
Query: 543 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTV 601
R E++DFS PF+ GIS+M+ + +FL+P + +W M V V+V +
Sbjct: 504 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 562
Query: 602 FIFEYLSPVGYNRSLATGKRPGGS-----TFTIGKSIWLLWALVFNNSVPVENPRGTTSK 656
F+ SP ++ + G S F I S+W + +PR + +
Sbjct: 563 FLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGR 621
Query: 657 IMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNG 716
I+ VW FF +I ++SYTANLAAF+ E V + D Q + +GT+ +G
Sbjct: 622 IVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLDSG 675
Query: 717 STEKNIRSN----YPDMHSYMVRYNQPRV-----EEALTQLKAGK-LDAFIYDAAVLNYM 766
ST++ R + Y M +YM R +P V E + +++ K AF+ ++ + Y+
Sbjct: 676 STKEFFRRSKIAVYEKMWTYM-RSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYI 734
Query: 767 ARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL-- 824
++ + C + +G + GYG+A KGS P++LA+L+ ++ L+ W
Sbjct: 735 EQR-KPCDTMKVGGN--LDSKGYGVATPKGSSLGTPVNLAVLKLSEAGVLDKLKNKWWYD 791
Query: 825 SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 862
G C + + +S L + N+AGVFY+L+ +GL++LV
Sbjct: 792 KGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLV 831
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 171 bits (434), Expect = 3e-42
Identities = 120/400 (30%), Positives = 205/400 (51%), Gaps = 34/400 (8%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDG--VWNGMIGEVFYQRADMAIGSLTI 542
+G+C+D+ +A GF Y L +V +GK+G + +WNGM+GE+ Y +AD+AI LTI
Sbjct: 443 EGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTI 502
Query: 543 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTV 601
R E++DFS PF+ GIS+M+ + +FL+P + +W M V V+V +
Sbjct: 503 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 561
Query: 602 FIFEYLSPVGYNR-----SLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSK 656
F+ SP ++ T + F I S+W + +PR + +
Sbjct: 562 FLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDI-SPRSLSGR 620
Query: 657 IMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNG 716
I+ VW FF +I ++SYTANLAAF+ E V + D Q + +GT+ +G
Sbjct: 621 IVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQ------TEIAYGTLDSG 674
Query: 717 STEKNIRSN----YPDMHSYMVRYNQPRV-----EEALTQLKAGK-LDAFIYDAAVLNYM 766
ST++ R + + M +YM R +P V E + +++ K A++ ++ + Y+
Sbjct: 675 STKEFFRRSKIAVFDKMWTYM-RSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI 733
Query: 767 ARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL-- 824
++ + C + +G + GYGIA KGS + ++LA+L+ ++ L+ W
Sbjct: 734 EQR-KPCDTMKVGGN--LDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYD 790
Query: 825 SGICHN--DKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 862
G C + + +S L + N+AGVFY+L+ +GL++LV
Sbjct: 791 KGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLV 830
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 171 bits (433), Expect = 4e-42
Identities = 120/400 (30%), Positives = 205/400 (51%), Gaps = 34/400 (8%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDG--VWNGMIGEVFYQRADMAIGSLTI 542
+G+C+D+ +A IG Y + +V +GK+G + +WNGM+GE+ Y +A++AI LTI
Sbjct: 444 EGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTI 503
Query: 543 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTV 601
R E++DFS PF+ GIS+M+ + +FL+P + +W M V V+V +
Sbjct: 504 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 562
Query: 602 FIFEYLSPVGYNRSLATGKRPGGS-----TFTIGKSIWLLWALVFNNSVPVENPRGTTSK 656
F+ SP ++ + G S F I S+W + +PR + +
Sbjct: 563 FLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGR 621
Query: 657 IMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNG 716
I+ VW FF +I ++SYTANLAAF+ E V + D Q + +GT+ +G
Sbjct: 622 IVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLDSG 675
Query: 717 STEKNIRSN----YPDMHSYMVRYNQPRV-----EEALTQLKAGK-LDAFIYDAAVLNYM 766
ST++ R + Y M +YM R +P V E + +++ K AF+ ++ + Y+
Sbjct: 676 STKEFFRRSKIAVYEKMWTYM-RSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYI 734
Query: 767 ARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL-- 824
++ + C + +G + GYG+A KGS ++LA+L+ ++ L+ W
Sbjct: 735 EQR-KPCDTMKVGGN--LDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYD 791
Query: 825 SGICHN--DKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 862
G C + + +S L + N+AGVFY+L+ +GL++LV
Sbjct: 792 KGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLV 831
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 167 bits (424), Expect = 5e-41
Identities = 121/403 (30%), Positives = 203/403 (50%), Gaps = 38/403 (9%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDG--VWNGMIGEVFYQRADMAIGSLTI 542
+G+C+D+ +A + Y L +V +GK+G + +WNGM+GE+ Y RAD+A+ LTI
Sbjct: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
Query: 543 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTV 601
R E++DFS PF+ GIS+M+ + +FL+P + +W M V V+V +
Sbjct: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
Query: 602 FIFEYLSPVGY-----NRSLATGKRPGG--STFTIGKSIWLLWALVFNNSVPVENPRGTT 654
F+ SP + N + P + F I S+W + +PR +
Sbjct: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
Query: 655 SKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVP 714
+I+ VW FF +I ++SYTANLAAF+ E V + D Q + +GT+
Sbjct: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
Query: 715 NGSTEKNIRSN----YPDMHSYMVRYNQPRVEEALT-------QLKAGKLDAFIYDAAVL 763
+GST++ R + Y M SYM + +P V T + GK AF+ ++ +
Sbjct: 684 SGSTKEFFRRSKIAVYEKMWSYM-KSAEPSVFTKTTADGVARVRKSKGKF-AFLLESTMN 741
Query: 764 NYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLW 823
Y+ ++ + C + +G + GYG+A KGS P++LA+L+ ++ L+ W
Sbjct: 742 EYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKW 798
Query: 824 L--SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 862
G C + + +S L + N+AGVFY+L+ +GL+++V
Sbjct: 799 WYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMV 841
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 167 bits (424), Expect = 5e-41
Identities = 119/412 (28%), Positives = 206/412 (50%), Gaps = 43/412 (10%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGK-KIDGVWNGMIGEVFYQRADMAIGSLTIN 543
+GF ID+L L++ +GF+Y++Y+ + K+G + DG WNG++GE+ ++RAD+ I +LTI
Sbjct: 468 QGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTIT 527
Query: 544 EERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFI 603
+R +VDF+ +++ + V++ R+ TV A L P+ ++W + L +V + V++
Sbjct: 528 PDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVL-LVGLLVYL 586
Query: 604 FEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGT-TSKIMVLVW 662
+L+P T + T+ S+W ++ V P T +++M+ W
Sbjct: 587 LNWLNPPRLQMGSMT-------STTLYNSMWFVYGSFVQQGGEV--PYTTLATRMMMGAW 637
Query: 663 AFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNI 722
FA+I ++SYTANLAAF+ ++ L D Q + +GTV + + +++
Sbjct: 638 WLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQ------TEIPYGTVLDSAVYEHV 691
Query: 723 RS------NYPDMHSYMVRY---------NQPRVEEALTQLKAGKLDAFIYDAAVLNYMA 767
R M+S M R N + + ++K G AF++DAAVL Y+A
Sbjct: 692 RMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNY-AFVWDAAVLEYVA 750
Query: 768 RKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGI 827
D C TIG+ A GYGIAL GS ++ +L+ + ++++L+ W
Sbjct: 751 INDPDCSFYTIGN--TVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKN 808
Query: 828 CHNDKIEVMSSK-----LDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLR 874
D + +K LDI + AGVF +L + LS + E +W R
Sbjct: 809 GQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLE--TWWNKR 858
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 164 bits (415), Expect = 5e-40
Identities = 119/423 (28%), Positives = 207/423 (48%), Gaps = 41/423 (9%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGV-WNGMIGEVFYQRADMAIGSLTIN 543
KGF ID+L LA +GF Y++Y +G++G ++ WNGMIGE+ +RAD+AI ++TI
Sbjct: 464 KGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITIT 523
Query: 544 EERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFI 603
ER +VDFS +++ + +++ + +S + P+ AVW + + VV V +F+
Sbjct: 524 PERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACI-AAAIPVVGVLIFV 582
Query: 604 FEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWA 663
+ V A RP S T+ +IW+++ F + +I++ W
Sbjct: 583 LNRIQAV--RAQSAAQPRPSASA-TLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWW 638
Query: 664 FFAVIFLASYTANLAAFMIQEEYVDTVSGLSD--RKFQRPQEQYPPLKFGTVPNGSTEKN 721
F +I +SYTANLAAF+ TVS + + R FQ +Q + +GTV + + +
Sbjct: 639 LFTLIVCSSYTANLAAFL-------TVSRMDNPIRTFQDLSKQV-EMSYGTVRDSAVYEY 690
Query: 722 IR----------SNYPDMHSYMVRYN-----QPRVEEALTQLKAGKLDAFIYDAAVLNYM 766
R S + ++ + + E + + K G AF++D AV+ Y
Sbjct: 691 FRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNY-AFLWDVAVVEYA 749
Query: 767 ARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSG 826
A D+ C + IG+ ++ GYGIAL GS ++ +L+ ++++L++ W
Sbjct: 750 ALTDDDCSVTVIGNS--ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPH 807
Query: 827 ICHNDKIEVMSSKLD-----IDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTH 881
+ D S++ D + + AGVF +L + + L+ LV A E ++W C T
Sbjct: 808 MGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWWNSNRCHQETP 865
Query: 882 RMD 884
+ D
Sbjct: 866 KED 868
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 164 bits (415), Expect = 5e-40
Identities = 120/403 (29%), Positives = 202/403 (50%), Gaps = 38/403 (9%)
Query: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDG--VWNGMIGEVFYQRADMAIGSLTI 542
+G+C+D+ +A + Y L +V +GK+G + +WNGM+GE+ Y RAD+A+ LTI
Sbjct: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
Query: 543 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTV 601
R E++DFS PF+ GIS+M+ + +FL+P + +W M V V+V +
Sbjct: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
Query: 602 FIFEYLSPVGY-----NRSLATGKRPGG--STFTIGKSIWLLWALVFNNSVPVENPRGTT 654
F+ SP + N + P + F I S+W + +PR +
Sbjct: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
Query: 655 SKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVP 714
+I+ VW FF +I ++SYTANLAAF+ E V + D Q + +GT+
Sbjct: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
Query: 715 NGSTEKNIRSN----YPDMHSYMVRYNQPRVEEALT-------QLKAGKLDAFIYDAAVL 763
+GST++ R + Y M SYM + +P V T + GK AF+ ++ +
Sbjct: 684 SGSTKEFFRRSKIAVYEKMWSYM-KSAEPSVFTKTTADGVARVRKSKGKF-AFLLESTMN 741
Query: 764 NYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLW 823
Y+ ++ + C + +G + GYG+A KGS ++LA+L+ ++ L+ W
Sbjct: 742 EYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKW 798
Query: 824 L--SGICHN--DKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 862
G C + + +S L + N+AGVFY+L+ +GL+++V
Sbjct: 799 WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMV 841
>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
Length = 416
Score = 80.1 bits (196), Expect = 1e-14
Identities = 108/400 (27%), Positives = 138/400 (34%), Gaps = 78/400 (19%)
Query: 903 PPPAKPP-PPPQPLPSPAYPAPRPAP-GPAPFVPRERASVDRWRRTKGAGPPGGAGLADG 960
PPP KP PPPQ P P P P GP P + R+ + +G P GG
Sbjct: 73 PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGN----- 127
Query: 961 FHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVR-DKEPAEP 1019
+PQG G+ + P +P PP PQ PPP R + P
Sbjct: 128 --------QPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGK 179
Query: 1020 PAGAFP-GFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPAR----WPRSDPESQPLLGP 1074
P G P G P PP GPP + + + PP P + P+ D +SQ P
Sbjct: 180 PQGPPPQGGNQPQGPPPPPGKPQGPP-PQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSP 238
Query: 1075 GAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWF 1134
G G GG P PPP PP P G GG +P
Sbjct: 239 -PGKPQGPPPQGGNQPQGPPP----PPGKPQ----------------GPPPQGGNKP--- 274
Query: 1135 ADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRH 1194
P P + GPPP + S + G PP+ G + PPP
Sbjct: 275 -QGPPPPGKPQGPPP-QGGSKSRSSRSPPGKPQGPPPQGG----------NQPQGPPPPP 322
Query: 1195 LSCSHDGLDGG--WWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHR 1252
GG PPPP GP P+ ++ RS P +P+ P
Sbjct: 323 GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQ---------GPPQQE 373
Query: 1253 HRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSR 1292
G PP P + + P+A PA + GP R
Sbjct: 374 GNNPQG-----PPPPAGGNPQQ----PQAPPAGQPQGPPR 404
Score = 57.4 bits (137), Expect = 9e-08
Identities = 78/294 (26%), Positives = 93/294 (31%), Gaps = 24/294 (8%)
Query: 978 GEARAAPRGAAGRPLSPPAAQPPQKP--PPSYFAIVRDKEPAEP--PAGAFP-GFPSPPA 1032
G + AP +P PP+ PP KP PP P P P G P G P
Sbjct: 34 GNPQGAPPQGGNKPQGPPS--PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQG 91
Query: 1033 PPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPL-LGPGAGGAGGTGGAGGGAPA 1091
PP PP + SPP + P +QP P G G GG P
Sbjct: 92 PPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 151
Query: 1092 APPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGR 1151
PPP P P D + S S + G GG +P P P + GPPP
Sbjct: 152 GPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQP---QGPPPPPGKPQGPPP-- 206
Query: 1152 YWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPP 1211
G G PP+ + R PPP+ G + PPP
Sbjct: 207 QGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQ-------GGNQPQGPPPP 259
Query: 1212 PPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPP 1265
P GP P+ G P P P R G PPP
Sbjct: 260 PGKPQGPPPQG----GNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPP 309
Score = 55.8 bits (133), Expect = 3e-07
Identities = 67/248 (27%), Positives = 81/248 (32%), Gaps = 39/248 (15%)
Query: 898 SAEAAPPPAKPP-PPPQ-------PLPSPAYPAPRPAPG-------PAPFVPRERASVDR 942
S + PP KP PPPQ P P P P P G P P P+
Sbjct: 170 SRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGD 229
Query: 943 WRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQK 1002
+ PPG G +PQG G+ + P +P PP PQ
Sbjct: 230 NKSQSARSPPGKPQGPPP----QGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG 285
Query: 1003 PPPSYFAIVR-DKEPAEPPAGAFP-GFPSPPAPPAAAATAVGPPLCRLAFEDESPPAP-- 1058
PPP + R + P P G P G P PP GPP + + + PP P
Sbjct: 286 PPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP-PQGGNKPQGPPPPGK 344
Query: 1059 --------------ARWPRSDPESQPLL-GPGAGGAGGTGGAGGGAPAAPPPCRAAPPPC 1103
AR P P+ P G G G P APP + PP
Sbjct: 345 PQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPR 404
Query: 1104 PYLDLEPS 1111
P PS
Sbjct: 405 PPQGGRPS 412
Score = 51.6 bits (122), Expect = 5e-06
Identities = 51/179 (28%), Positives = 64/179 (35%), Gaps = 29/179 (16%)
Query: 904 PPAKPPPPPQPLPSPAY----PAPRPAPGPAPFVPRERASVDRWRRT---KGAGPPGGAG 956
P PPPP +P P P P PG P + S R R+ K GPP G
Sbjct: 253 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGG 312
Query: 957 LADGFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEP 1016
+PQG G+ + P +P PP PQ PPP + R
Sbjct: 313 -----------NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRS--- 358
Query: 1017 AEPPAGAFPGFP-----SPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQP 1070
A P G G P +P PP A P A + + PP P P+ S+P
Sbjct: 359 ARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRP---PQGGRPSRP 414
Score = 41.2 bits (95), Expect = 0.007
Identities = 36/106 (33%), Positives = 42/106 (39%), Gaps = 14/106 (13%)
Query: 903 PPPAKPP-PPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRT---KGAGPPGGAGLA 958
PPP KP PPPQ P P P PG P + S R R+ K GPP G
Sbjct: 320 PPPGKPQGPPPQGGNKPQGPPP---PGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEG-- 374
Query: 959 DGFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPP 1004
+ GP P G + +A P G P PP P +PP
Sbjct: 375 ---NNPQGP--PPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPP 415
Score = 33.9 bits (76), Expect = 1.1
Identities = 48/178 (26%), Positives = 61/178 (34%), Gaps = 24/178 (13%)
Query: 1064 SDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGG 1123
S ES L+ GA GG P +PP PP P +P + G
Sbjct: 24 SQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPP--PQGGNQPQGPPPPPGKPQGP 81
Query: 1124 ASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRA--GSWDYLPPRSGPAAWHCR 1181
GG +P P P + GPPP DK R+ G PP+ G
Sbjct: 82 PPQGGNKP----QGPPPPGKPQGPPP----QGDKSRSPRSPPGKPQGPPPQGG------- 126
Query: 1182 HCASLELLPPPRHLSCSHDGLDGG--WWAPPPPPWAAGPLPRRRARCGCPRSHPHRPR 1237
+ PPP GG PPPP GP P+ + RS P +P+
Sbjct: 127 ---NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQ 181
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.448
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,381,427
Number of Sequences: 37866
Number of extensions: 4784873
Number of successful extensions: 78406
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 662
Number of HSP's successfully gapped in prelim test: 1768
Number of HSP's that attempted gapping in prelim test: 33050
Number of HSP's gapped (non-prelim): 27557
length of query: 1336
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1222
effective length of database: 13,930,794
effective search space: 17023430268
effective search space used: 17023430268
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.