Search of human proteins with 153792669

Search of human proteins with 153792669

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide
2 (neuronal) [Homo sapiens]
         (529 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...  1103   0.0  
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   580   e-166
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   549   e-156
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    516   e-146
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   473   e-133
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   466   e-131
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   452   e-127
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     451   e-127
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   424   e-119
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   410   e-114
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   357   1e-98
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   347   1e-95
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   330   3e-90
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   310   2e-84
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   303   3e-82
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   298   6e-81
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   284   2e-76
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              259   6e-69
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   206   4e-53
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   204   1e-52
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              197   3e-50
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   191   2e-48
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   159   5e-39
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   158   1e-38
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   152   6e-37
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p...    88   2e-17
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso...    85   1e-16
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...    85   1e-16
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso...    84   4e-16
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is...    84   4e-16

>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score = 1103 bits (2853), Expect = 0.0
 Identities = 529/529 (100%), Positives = 529/529 (100%)

Query: 1   MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED 60
           MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
Sbjct: 1   MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED 60

Query: 61  RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 120
           RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
Sbjct: 61  RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 120

Query: 121 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 180
           RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
Sbjct: 121 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 180

Query: 181 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY 240
           SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
Sbjct: 181 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY 240

Query: 241 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC 300
           NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
Sbjct: 241 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC 300

Query: 301 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 360
           ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
Sbjct: 301 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 360

Query: 361 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE 420
           TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
Sbjct: 361 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE 420

Query: 421 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL 480
           DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
Sbjct: 421 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL 480

Query: 481 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 529
           RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
Sbjct: 481 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 529


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  580 bits (1496), Expect = e-166
 Identities = 287/373 (76%), Positives = 309/373 (82%), Gaps = 9/373 (2%)

Query: 25  GGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTET----EDRLFKHLFRGYNRWARPVPNT 80
           GG  A R  P     PL     T L +  SH ET    E+RL K LF GYN+W+RPV N 
Sbjct: 4   GGPGAPRLLP-----PLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANI 58

Query: 81  SDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMI 140
           SDVV+VRFGLSIAQLIDVDEKNQMMTTNVW+KQEW DYKLRW+P D+ N+TS+R+PSE+I
Sbjct: 59  SDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELI 118

Query: 141 WIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMK 200
           W PDIVLYNNADG+FAVTH+TKAHLF  G V W PPAIYKSSCSIDVTFFPFDQQNC MK
Sbjct: 119 WRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMK 178

Query: 201 FGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFV 260
           FGSWTYDKAKIDL  M   VD  D+WESGEW IV+A GTYN++KY+CCAEIYPD+TYAFV
Sbjct: 179 FGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFV 238

Query: 261 IRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPS 320
           IRRLPLFYTINLIIPCLLISCLTVLVFYLPS+CGEKITLCISVLLSLTVFLLLITEIIPS
Sbjct: 239 IRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPS 298

Query: 321 TSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLM 380
           TSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP THTMP WVR   L  VPR LLM
Sbjct: 299 TSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLM 358

Query: 381 NRPPPPVELCHPL 393
            RP    + C  L
Sbjct: 359 KRPSVVKDNCRRL 371



 Score =  119 bits (297), Expect = 9e-27
 Identities = 55/70 (78%), Positives = 63/70 (90%)

Query: 460 LLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGL 519
           L LSP + +A+EGV YIADHL++ED D SVKEDWKYVAMVIDRIFLW+FIIVC LGT+GL
Sbjct: 558 LPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGL 617

Query: 520 FLPPFLAGMI 529
           FLPP+LAGMI
Sbjct: 618 FLPPWLAGMI 627


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  549 bits (1414), Expect = e-156
 Identities = 280/483 (57%), Positives = 345/483 (71%), Gaps = 25/483 (5%)

Query: 56  TETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEW 115
           +E E RLF+ LF  YN   RPV N SD VI+ F +S++QL+ VDE NQ+M TN+WLKQ W
Sbjct: 32  SEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIW 91

Query: 116 SDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVP 175
           +DYKL+WNP+D+G    +RVP++ IW PDIVLYNNA G+F V   TKA L  TG V W+P
Sbjct: 92  NDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIP 151

Query: 176 PAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVN 235
           PAI+KSSC IDVT+FPFD QNC MKFGSW+YDKAKIDL  +  +++LKDYWESGEWAI+ 
Sbjct: 152 PAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIK 211

Query: 236 ATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGE 295
           A G  +  KY+CC EIYPD+TY+  IRRLPLFYTINLIIPCLLIS LTVLVFYLPSDCGE
Sbjct: 212 APGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGE 271

Query: 296 KITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHR 355
           K+TLCISVLLSLTVFLL+ITE IPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVH+R
Sbjct: 272 KVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYR 331

Query: 356 SPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREV 415
           +P+THTMP WV+   L  +PR + M RP            K  P Y    SN++   R  
Sbjct: 332 TPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQ----KPRPLYGAELSNLNCFSR-- 385

Query: 416 VVEEEDRWACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLS 463
               E +    G+  P    +C + H            L   +S    +A+L      LS
Sbjct: 386 ---AESKGCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLS--ALS 438

Query: 464 PHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPP 523
           P +++A++ V YIA+++++++    +++DWKYVAMVIDRIFLW+F +VC LGT GLFL P
Sbjct: 439 PEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQP 498

Query: 524 FLA 526
            +A
Sbjct: 499 LMA 501


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  516 bits (1328), Expect = e-146
 Identities = 258/473 (54%), Positives = 327/473 (69%), Gaps = 22/473 (4%)

Query: 58  TEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSD 117
           TE+RLF  LF  YN++ RPV N SD V V F ++I QL +VDE NQ+M TN+WL+  W+D
Sbjct: 33  TEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWND 92

Query: 118 YKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPA 177
           YKLRW+P ++  I +LRVP++ IW PDIVLYNNA G+F V   TKA L   G + W PPA
Sbjct: 93  YKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPA 152

Query: 178 IYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNAT 237
           I+KSSC +D+TFFPFD QNC +KFGSWTYDKA+IDL  +   VD+ D+WE+ EW I++A+
Sbjct: 153 IFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDAS 212

Query: 238 GTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKI 297
           G  +  KY+CC EIY D+TY+F IRRLP+FYTINLIIPCL IS LTVLVFYLPSDCGEK+
Sbjct: 213 GYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKV 272

Query: 298 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP 357
           TLCISVLLSLTVFLL+ITE IPSTSLV+PL+GEYLLFTMIFVTLSIV+TVFVLN+H+R+P
Sbjct: 273 TLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTP 332

Query: 358 STHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVV 417
           +THTMP WV+   L  +P+ LLM  P                      +  DA  R +  
Sbjct: 333 TTHTMPRWVKTVFLKLLPQVLLMRWPLDKTR----------------GTGSDAVPRGLA- 375

Query: 418 EEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLL-----SPHMQKALEG 472
               +   A H  P     C H H  +  +  K     Q  + ++     SP ++  +  
Sbjct: 376 RRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINS 435

Query: 473 VHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFL 525
           V +IA++++S +    V++DWKYVAMV+DR+FLW+FIIVC  GT GLFL P L
Sbjct: 436 VQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLL 488


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  473 bits (1216), Expect = e-133
 Identities = 248/470 (52%), Positives = 320/470 (68%), Gaps = 46/470 (9%)

Query: 54  SHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQ 113
           S  E ED L +HLF+GY +W RPV +++D + V FGL I+QL+DVDEKNQ+MTTNVWLKQ
Sbjct: 24  SIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQ 83

Query: 114 EWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHW 173
           EW+D+KLRWNP D+G I S++VPSE +W+PDIVL+ NADG F  + MTK  + S GTV W
Sbjct: 84  EWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVW 143

Query: 174 VPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAI 233
            PPA YKSSC++DVTFFPFD+QNC MKFGSWTYD   +DL  + + VD KD++++GEW I
Sbjct: 144 TPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEI 203

Query: 234 VNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDC 293
           +NA G   +++    +  YP +TY+FV+RRLPLFYT+ LIIPCL +S LTVLVFYLPSD 
Sbjct: 204 LNAKGMKGNRRDGVYS--YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDE 261

Query: 294 GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVH 353
           GEK++L  SVL+SLTVFLL+I EIIPS+S VIPLIGEYLLF MIFVTLSI++TVFV+NVH
Sbjct: 262 GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVH 321

Query: 354 HRSPST-HTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEE 412
           HRS ST H M  WV+   L  +P+ L M          H  R           S+ + EE
Sbjct: 322 HRSSSTYHPMAPWVKRLFLQKLPKLLCMKD--------HVDRY----------SSPEKEE 363

Query: 413 REVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEG 472
            + VV+        G V                    K +  L +GE +L   ++KA + 
Sbjct: 364 SQPVVK--------GKVLEK-----------------KKQKQLSDGEKVLVAFLEKAADS 398

Query: 473 VHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLP 522
           + YI+ H++ E   S V +DWK+VA V+DRIFLWLF+IV   G++ +F P
Sbjct: 399 IRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTP 448


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  466 bits (1199), Expect = e-131
 Identities = 244/470 (51%), Positives = 313/470 (66%), Gaps = 16/470 (3%)

Query: 56  TETEDRLFKHLF--RGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQ 113
           T+TE+RL +HL     YN+  RP  N S++V V+  +S+AQLI V E+ Q+MTTNVWL Q
Sbjct: 26  TDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQ 85

Query: 114 EWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHW 173
           EW DY+L W P +F N+  +R+PS+ IW+PD+VLYNNADG + V+  + A +   G++ W
Sbjct: 86  EWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFW 145

Query: 174 VPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAI 233
           +PPAIYKS+C I+V  FPFDQQNC MKF SWTYD+ +IDL    +   L D+  SGEW I
Sbjct: 146 LPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDI 205

Query: 234 VNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDC 293
           V   G  N    D     Y D+TY F+IRR PLFYTINLIIPC+LI+ L +LVFYLPSDC
Sbjct: 206 VALPGRRNENPDD---STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC 262

Query: 294 GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVH 353
           GEK+TLCISVLL+LTVFLLLI++I+P TSL +PL+G+YL+FTM+ VT SIV +V VLNVH
Sbjct: 263 GEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVH 322

Query: 354 HRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEER 413
           HRSP+THTM  WV+   L  +P  L M +P      C   RL+L       E       R
Sbjct: 323 HRSPTTHTMAPWVKVVFLEKLPALLFMQQPR---HHCARQRLRLRRRQREREGAGALFFR 379

Query: 414 EVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGV 473
           E      D   C  + A   G   + G   +  +GP      + GE      +++A++GV
Sbjct: 380 E--APGADSCTCFVNRASVQGLAGAFGAEPAPVAGPG-----RSGE-PCGCGLREAVDGV 431

Query: 474 HYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPP 523
            +IADH+RSED D SV EDWKYVAMVIDR+FLW+F+ VC  GTIG+FL P
Sbjct: 432 RFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQP 481


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  452 bits (1163), Expect = e-127
 Identities = 241/475 (50%), Positives = 309/475 (65%), Gaps = 63/475 (13%)

Query: 49  LPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTN 108
           L +  S  + ED L K LF+ Y RW RPV + +D + ++FGL+I+QL+DVDEKNQ+MTTN
Sbjct: 37  LSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTN 96

Query: 109 VWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFST 168
           VWLKQEW D KLRWNP D+G I  +RVPS+ +W PDIVL++NADG F  T  TK  +   
Sbjct: 97  VWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTS-TKTVIRYN 155

Query: 169 GTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWES 228
           GTV W PPA YKSSC+IDVTFFPFD QNC MKFGSWTYD +++D+   +Q VD +D++++
Sbjct: 156 GTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDN 215

Query: 229 GEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY 288
           GEW IV+ATG+  ++   CC   YP VTY+FVI+RLPLFYT+ LIIPC+ +S LTVLVFY
Sbjct: 216 GEWEIVSATGSKGNRTDSCCW--YPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFY 273

Query: 289 LPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF 348
           LPS+ GEKI LC SVL+SLTVFLL+I EIIPS+S VIPLIGEYL+FTMIFVTLSI++TVF
Sbjct: 274 LPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVF 333

Query: 349 VLNVHHRSPSTH-TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESN 407
            +N+HHRS STH  M   VR   L  +P+ L M                         S+
Sbjct: 334 AINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCM------------------------RSH 369

Query: 408 VDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQ 467
           VD   R    +EE                          SGPK+              ++
Sbjct: 370 VD---RYFTQKEET----------------------ESGSGPKSS----------RNTLE 394

Query: 468 KALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLP 522
            AL+ + YI  H+  E+    V EDWK++A V+DR+FLW F+ V  +G++GLF+P
Sbjct: 395 AALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVP 449


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  451 bits (1160), Expect = e-127
 Identities = 231/457 (50%), Positives = 302/457 (66%), Gaps = 18/457 (3%)

Query: 70  YNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGN 129
           YN   RP  ++S ++ ++  LS+AQLI V+E+ Q+MTTNVWLKQEW+DY+L WN + +  
Sbjct: 40  YNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEG 99

Query: 130 ITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTF 189
           +  LR+P++ IW+PDIVLYNNADG + V+  T   + S G+V W+PPAIYKS+C I+V +
Sbjct: 100 VNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKY 159

Query: 190 FPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCA 249
           FPFDQQNC +KF SWTYD  +ID+  M  T  + D+  SGEW IV   G       D   
Sbjct: 160 FPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQD--- 216

Query: 250 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV 309
             Y DVTY F+I+R PLFYTINLIIPC+L + L +LVFYLPSDCGEK+TLCISVLL+LT 
Sbjct: 217 PSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTF 276

Query: 310 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGA 369
           FLLLI++I+P TSL +PLIG+YL+FTM+ VT SIV +V VLNVHHRSPSTHTM  WV+  
Sbjct: 277 FLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRC 336

Query: 370 LLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV 429
            L  +P +L M RP P            SP+  +  S     + E            G+ 
Sbjct: 337 FLHKLPTFLFMKRPGP----------DSSPARAFPPSKSCVTKPEATATSTSPSNFYGNS 386

Query: 430 APSVGTLCSHGHLHSGASG---PKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDAD 486
              V    +     +G++    P+   L   G       +Q+ALEGV +IA H++++D D
Sbjct: 387 MYFVNPASAASKSPAGSTPVAIPRDFWLRSSGR--FRQDVQEALEGVSFIAQHMKNDDED 444

Query: 487 SSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPP 523
            SV EDWKYVAMV+DR+FLW+F+ VC LGT+GLFLPP
Sbjct: 445 QSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPP 481


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  424 bits (1091), Expect = e-119
 Identities = 214/466 (45%), Positives = 294/466 (63%), Gaps = 41/466 (8%)

Query: 56  TETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEW 115
           +E E RL   LF+ Y+   RPV +   VV V  GL + QLI+VDE NQ++TTNV LKQ+W
Sbjct: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQW 80

Query: 116 SDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVP 175
            DY L+WNP D+G +  + +PSE IW PD+VLYNNADG+FA+   TK  L  TG + W P
Sbjct: 81  VDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTP 140

Query: 176 PAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVN 235
           PAI+KS C I VT FPFD+QNC MK G+WTYD + + +       DL ++ ESGEW I  
Sbjct: 141 PAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKE 200

Query: 236 ATGTYNSKKYDCCAEI-YPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCG 294
           + G  +S  Y CC +  Y D+TY FV++RLPL++ +N+IIPCLL S LT LVFYLP+D G
Sbjct: 201 SRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG 260

Query: 295 EKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHH 354
           EK+TL ISVLLSLTVFLL+I E+IPSTS  +PLIG+Y+LFTM+FV  SI+ITV V+N HH
Sbjct: 261 EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH 320

Query: 355 RSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEERE 414
           RSPSTH MP+WVR   +  +P  +  +    P                    + + ++++
Sbjct: 321 RSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRP--------------------SREKQDKK 360

Query: 415 VVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVH 474
           +  E+ D           +  +       SG  GP          L+  P ++ A+EG+ 
Sbjct: 361 IFTEDID-----------ISDI-------SGKPGPPPMGF--HSPLIKHPEVKSAIEGIK 400

Query: 475 YIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLF 520
           YIA+ ++S+   ++   +WKYVAMV+D I L +F++VC +GT+ +F
Sbjct: 401 YIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVF 446


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  410 bits (1055), Expect = e-114
 Identities = 214/491 (43%), Positives = 294/491 (59%), Gaps = 66/491 (13%)

Query: 56  TETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQ-- 113
           +E E RL   LF+ Y+   RPV +   VV V  GL + QLI+VDE NQ++TTNV LKQ  
Sbjct: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGD 80

Query: 114 -----------------------EWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNN 150
                                  +W DY L+WNP D+G +  + +PSE IW PD+VLYNN
Sbjct: 81  MVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNN 140

Query: 151 ADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAK 210
           ADG+FA+   TK  L  TG + W PPAI+KS C I VT FPFD+QNC MK G+WTYD + 
Sbjct: 141 ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 200

Query: 211 IDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEI-YPDVTYAFVIRRLPLFYT 269
           + +       DL ++ ESGEW I  + G  +S  Y CC +  Y D+TY FV++RLPL++ 
Sbjct: 201 VAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFI 260

Query: 270 INLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIG 329
           +N+IIPCLL S LT LVFYLP+D GEK+TL ISVLLSLTVFLL+I E+IPSTS  +PLIG
Sbjct: 261 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 320

Query: 330 EYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVEL 389
           +Y+LFTM+FV  SI+ITV V+N HHRSPSTH MP+WVR   +  +P  +  +    P   
Sbjct: 321 KYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRP--- 377

Query: 390 CHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGP 449
                            + + +++++  E+ D           +  +       SG  GP
Sbjct: 378 -----------------SREKQDKKIFTEDID-----------ISDI-------SGKPGP 402

Query: 450 KAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFI 509
                     L+  P ++ A+EG+ YIA+ ++S+   ++   +WKYVAMV+D I L +F+
Sbjct: 403 PPMGF--HSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFM 460

Query: 510 IVCFLGTIGLF 520
           +VC +GT+ +F
Sbjct: 461 LVCIIGTLAVF 471


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  357 bits (916), Expect = 1e-98
 Identities = 193/488 (39%), Positives = 277/488 (56%), Gaps = 46/488 (9%)

Query: 57  ETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWS 116
           E + +L+K L + YN   RPV N S  + V F LS+ Q++DVDEKNQ++TTN+WL+  W+
Sbjct: 24  EFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWT 83

Query: 117 DYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPP 176
           D+ L+WN +++  + ++R P   IW PDI+LYN+AD  F  T  T   + S+G   ++PP
Sbjct: 84  DHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPP 143

Query: 177 AIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNA 236
            I+KSSC IDV +FPFD Q+CK+KFGSW+Y    +DL+  E   D+  Y  +GEW +V  
Sbjct: 144 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE--ADISGYIPNGEWDLVGI 201

Query: 237 TGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEK 296
            G  + + Y+CC E YPDVT+   +RR  L+Y +NL+IPC+LIS L +LVF LP+D GEK
Sbjct: 202 PGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEK 261

Query: 297 ITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRS 356
           I+L I+VLLSLTVF+LL+ EI+P+TS  +PLI +Y   TMI V LS+V+TV VL  HH  
Sbjct: 262 ISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHD 321

Query: 357 PSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVV 416
           P    MP W R  LL     +L M RP          +++ +  +     ++ + E   V
Sbjct: 322 PDGGKMPKWTRVILLNWCAWFLRMKRPGED-------KVRPACQHKQRRCSLASVEMSAV 374

Query: 417 VEEEDRWACAGHV---------------APSVGTLCSH--------GHLHSGASGPKAEA 453
                  A  G++                P  G +C           HL  G   P+ + 
Sbjct: 375 APPP---ASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGD- 430

Query: 454 LLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCF 513
                     P + K LE V YIA+  R +D   +V  +WK+ A V+DR+ L  F +   
Sbjct: 431 ----------PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI 480

Query: 514 LGTIGLFL 521
           + TIG+ +
Sbjct: 481 ICTIGILM 488


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  347 bits (891), Expect = 1e-95
 Identities = 190/487 (39%), Positives = 276/487 (56%), Gaps = 29/487 (5%)

Query: 49  LPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTN 108
           L  G   +E E RL + LF GY+   RP     D V V  GL +AQLI ++EK++ M+T 
Sbjct: 17  LAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTK 76

Query: 109 VWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFST 168
           V+L  EW+DY+L W+P +   I SLR+ +E +W+PD+VL NN DG F V       + S 
Sbjct: 77  VYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSD 136

Query: 169 GTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLE-------QMEQTVD 221
           G+V W PP IY+SSCSI VT+FPFD QNC M F S++YD +++ L+       Q  Q + 
Sbjct: 137 GSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIH 196

Query: 222 LKD--YWESGEWAIVNATGTYNSKKYDCCA---EIYPDVTYAFVIRRLPLFYTINLIIPC 276
           + +  + E+G+W I++          D          +V +  +IRR PLFY +N+I PC
Sbjct: 197 IHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPC 256

Query: 277 LLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTM 336
           +LI+ L + VFYLP D GEK+ L I  LL+LTVFLLL+ + +P TSL +P+I +YL+FTM
Sbjct: 257 ILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTM 316

Query: 337 IFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLK 396
           + VT S++++V VLN+HHRSP TH MP WVR   +  +P +L + RP P  +L       
Sbjct: 317 VLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHC 376

Query: 397 LSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQ 456
            SP   W     +   R+                PS              S P     + 
Sbjct: 377 SSPGSGWGRGTDEYFIRK---------------PPSDFLFPKPNRFQPELSAPDLRRFID 421

Query: 457 --EGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFL 514
                + L P +++ +  + YIA  L+ ++   ++KEDW++VAMV+DR+FLW FII   +
Sbjct: 422 GPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSV 481

Query: 515 GTIGLFL 521
           GT+ +FL
Sbjct: 482 GTLVIFL 488


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  330 bits (845), Expect = 3e-90
 Identities = 179/486 (36%), Positives = 282/486 (58%), Gaps = 43/486 (8%)

Query: 59  EDRLFKHLF--RGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWS 116
           E+RL +HLF  +GYN+  RPV +  + V V   L+++ LI + E  + +TTNVW++  W+
Sbjct: 25  EERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWT 84

Query: 117 DYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPP 176
           D +L+WN  +FGNI+ LR+P +M+W+P+IVL NN DG F +++     ++  G V+W+PP
Sbjct: 85  DNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPP 144

Query: 177 AIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQT------------VDLKD 224
           AI++SSC I VT+FPFD QNC +KF S  Y   +I L   +              +D + 
Sbjct: 145 AIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG 204

Query: 225 YWESGEWAIVNATGTYN-SKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLT 283
           + E+GEW IV+     N   +    +    D+T+  +IRR PLFY IN+++PC+LIS + 
Sbjct: 205 FTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMV 264

Query: 284 VLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSI 343
            LVFYLP+D GEK ++ ISVLL+ +VFLLLI++ +P+TS+ IPLIG++LLF M+ VT+ +
Sbjct: 265 NLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVV 324

Query: 344 VITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRP----PPPVELCHPLR----L 395
           VI V VLN+H R+PSTH +   V+   L  +P  L M+RP    P P  L         +
Sbjct: 325 VICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYI 384

Query: 396 KLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALL 455
             +  Y  L+S  D     ++ E++                  HG      +  +  A  
Sbjct: 385 SKAEEYFLLKSRSD-----LMFEKQSE---------------RHGLARRLTTARRPPASS 424

Query: 456 QEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLG 515
           ++ +  L   ++ A++G ++I +H+R ++  +  K+ W  VA  +DR+ L++   V  +G
Sbjct: 425 EQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVG 484

Query: 516 TIGLFL 521
           T  +FL
Sbjct: 485 TAWIFL 490


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  310 bits (794), Expect = 2e-84
 Identities = 169/460 (36%), Positives = 260/460 (56%), Gaps = 23/460 (5%)

Query: 61  RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 120
           +LF  LF  Y+   RPV +T  V+ V   ++++Q+ D+DE+NQ++T  +W++Q W D  L
Sbjct: 33  KLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYL 92

Query: 121 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 180
            W+   +  + S+R+PS+++W PDIVLYN AD E +    T   L   G + W  PAI K
Sbjct: 93  TWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITK 152

Query: 181 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY 240
           SSC +DVT+FPFD Q C + FGSWTY+  ++D+     + DL D+ E  EW +       
Sbjct: 153 SSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVK 212

Query: 241 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC 300
           N   Y CC+E YPDVT+  +++R   FY +NL+IPC+LIS L  L FYLP+  GEK++L 
Sbjct: 213 NVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLG 272

Query: 301 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 360
           +++LL++TVF L++ EI+P++  V PLIG+Y + TM  +T S  +T+ V+N+H       
Sbjct: 273 VTILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTALTIMVMNIHFCGAEAR 331

Query: 361 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLK--LSPSYHWL-ESNVDAEEREVVV 417
            +PHW R  +L  + R L +          H  R +  L+  Y  L ESN+ A   + + 
Sbjct: 332 PVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLS 391

Query: 418 EEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIA 477
            ++D       +   +G          G +  +AE+   + ++L           + YIA
Sbjct: 392 RKKD---MNKRLKNDLGC--------QGKNPQEAESYCAQYKVL--------TRNIEYIA 432

Query: 478 DHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTI 517
             L+   A +S   +WK VA VIDR F+W+F I+ F+ TI
Sbjct: 433 KCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTI 472


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  303 bits (775), Expect = 3e-82
 Identities = 165/448 (36%), Positives = 237/448 (52%), Gaps = 45/448 (10%)

Query: 61  RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 120
           +LF+ LF  Y    RPV +T   + V   ++++Q+ID+DE+NQ++T  +W++QEW+D  L
Sbjct: 32  KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYL 91

Query: 121 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 180
           RW+P  +G + ++R+PS ++W PDIVLYN AD +   +  T   L   G V W  PAI +
Sbjct: 92  RWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITR 151

Query: 181 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY 240
           SSC +DV  FPFD Q+C + FGSWT+   ++D+        L D+ E+ EW ++      
Sbjct: 152 SSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARR 211

Query: 241 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC 300
               Y CC+E YPDVT+  ++RR    Y  NL++PC+LIS L  L F+LP+D GEK++L 
Sbjct: 212 RVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLG 271

Query: 301 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 360
           ++VLL+LTVF LL+ E +P    V PLIG+Y + TM  VT S  +T+ ++N+H+  PS  
Sbjct: 272 VTVLLALTVFQLLLAESMPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVR 330

Query: 361 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE 420
            +P W R  LLG + R L +     P     P  L  SP                     
Sbjct: 331 PVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQ-------------------- 370

Query: 421 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL 480
                    +P  G     G  H      + EALL                 V  IA+  
Sbjct: 371 ---------SPEGGAGPPAGPCHEPRCLCRQEALLHH---------------VATIANTF 406

Query: 481 RSEDADSSVKEDWKYVAMVIDRIFLWLF 508
           RS  A     EDWK +A V+DR FL +F
Sbjct: 407 RSHRAAQRCHEDWKRLARVMDRFFLAIF 434


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  298 bits (764), Expect = 6e-81
 Identities = 174/491 (35%), Positives = 267/491 (54%), Gaps = 67/491 (13%)

Query: 59  EDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDY 118
           E RL+ HLF  Y+  +RPV    D V +   +++  LI ++EK + +TT+VW+  +W DY
Sbjct: 24  ELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDY 83

Query: 119 KLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAI 178
           +L ++  DFG I +LRVPSE++W+P+IVL NN DG+F V +     ++  G+V W+PPAI
Sbjct: 84  RLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAI 143

Query: 179 YKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQT---------VDLKDYWESG 229
           Y+S C+++VT+FPFD QNC + F S TY+  +++                +D + Y E+G
Sbjct: 144 YRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENG 203

Query: 230 EWAIVNATGTYNSKKYDCCAEIYP---DVTYAFVIRRLPLFYTINLIIPCLLISCLTVLV 286
           EWAI    G    +++   A   P   DV Y+ +IRR PLFY IN+I+PC+LIS L +L 
Sbjct: 204 EWAIDFCPGVI--RRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLA 261

Query: 287 FYLPSDCG-EKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVI 345
           ++LP+  G +K T+ I+VLL+ TVFL LI + IP TSL +PL+G +L+F M+  TL ++ 
Sbjct: 262 YFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMN 321

Query: 346 TVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLE 405
            V VLNV  R+P+TH M   +R  LL  +PR  L+  PPPP                   
Sbjct: 322 CVIVLNVSQRTPTTHAMSPRLRHVLLELLPR--LLGSPPPP------------------- 360

Query: 406 SNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGEL----- 460
                        E  R A     A SVG L     L      P++E L+ EG+      
Sbjct: 361 -------------EAPRAASPPRRASSVGLLLRAEELI--LKKPRSE-LVFEGQRHRQGT 404

Query: 461 ----------LLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFII 510
                       +P ++  ++ V+++A+  R ++A      DW  +   +D I  W  ++
Sbjct: 405 WTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALV 464

Query: 511 VCFLGTIGLFL 521
           +  +G+  +FL
Sbjct: 465 LFSVGSSLIFL 475


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  284 bits (726), Expect = 2e-76
 Identities = 173/486 (35%), Positives = 257/486 (52%), Gaps = 27/486 (5%)

Query: 52  GGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWL 111
           G      E+RL   L + Y+   RP    SDVV V   L++  LI ++E+ + +TTNVW+
Sbjct: 19  GAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWI 78

Query: 112 KQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTV 171
           + +W DY+LRW+P D+  +  LRVPS M+W PDIVL NN DG F V       +   G +
Sbjct: 79  EMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCI 138

Query: 172 HWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQT--------VDLK 223
           +W+PPAI++S+CSI VT+FPFD QNC + F S TY   +IDL+  ++         +D +
Sbjct: 139 YWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPE 198

Query: 224 DYWESGEWAIVNATGTYNSKKYDCCAEI-YPDVTYAFVIRRLPLFYTINLIIPCLLISCL 282
            + E+GEWAI +              E  +  V +  +I+R PLFY IN+I PC+LIS +
Sbjct: 199 AFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSV 258

Query: 283 TVLVFYLPSDC-GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTL 341
            +L+ +LP+   G+K T+ I+VLL+ TVFL L+ + +P TS  +PLI +YL F ++   L
Sbjct: 259 AILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTIL 318

Query: 342 SIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMN-RPPPPVELCHPLRLKLSPS 400
            +V  V VLNV  RSP TH+M   VR   L  +P+ L M+ RP  P  +        + S
Sbjct: 319 IVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLAPAAVQDTQSRLQNGS 378

Query: 401 YHWLESNVDAEEREVVVEEED----RWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQ 456
             W  S    EE  + +   +    +W   G VA ++  L           GP+      
Sbjct: 379 SGW--SITTGEEVALCLPRSELLFQQWQRQGLVAAALEKL---------EKGPELGLSQF 427

Query: 457 EGEL-LLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLG 515
            G L   +P +Q  +E  + IA     +    +  E+W  V  V+DR+     + +   G
Sbjct: 428 CGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLSLFICG 487

Query: 516 TIGLFL 521
           T G+FL
Sbjct: 488 TAGIFL 493


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  259 bits (661), Expect = 6e-69
 Identities = 150/394 (38%), Positives = 211/394 (53%), Gaps = 46/394 (11%)

Query: 151 ADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAK 210
           AD  F  T  T   + S+G   ++PP I+KSSC IDV +FPFD Q+CK+KFGSW+Y    
Sbjct: 28  ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87

Query: 211 IDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTI 270
           +DL+  E   D+  Y  +GEW +V   G  + + Y+CC E YPDVT+   +RR  L+Y +
Sbjct: 88  LDLQMQE--ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 145

Query: 271 NLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGE 330
           NL+IPC+LIS L +LVF LP+D GEKI+L I+VLLSLTVF+LL+ EI+P+TS  +PLI +
Sbjct: 146 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 205

Query: 331 YLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELC 390
           Y   TMI V LS+V+TV VL  HH  P    MP W R  LL     +L M RP       
Sbjct: 206 YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGED---- 261

Query: 391 HPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV---------------APSVGT 435
              +++ +  +     ++ + E   V       A  G++                P  G 
Sbjct: 262 ---KVRPACQHKQRRCSLASVEMSAVAPPP---ASNGNLLYIGFRGLDGVHCVPTPDSGV 315

Query: 436 LCSH--------GHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADS 487
           +C           HL  G   P+ +           P + K LE V YIA+  R +D   
Sbjct: 316 VCGRMACSPTHDEHLLHGGQPPEGD-----------PDLAKILEEVRYIANRFRCQDESE 364

Query: 488 SVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFL 521
           +V  +WK+ A V+DR+ L  F +   + TIG+ +
Sbjct: 365 AVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 398


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  206 bits (524), Expect = 4e-53
 Identities = 109/347 (31%), Positives = 190/347 (54%), Gaps = 13/347 (3%)

Query: 46  PTALPQGGSHTETED------RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVD 99
           PT L QG +            RL  +L   Y +  RPV +      V   + +  +++VD
Sbjct: 21  PTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVD 80

Query: 100 EKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTH 159
           EKNQ++TT +W +Q W+D  L+WNP DF NIT L +P++ IW+PDI++    D   +  +
Sbjct: 81  EKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKS-PN 139

Query: 160 MTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSW--TYDKAKIDLEQME 217
           +   ++   G V    P    ++CS+D+  FPFD QNC + F SW  T     I L ++ 
Sbjct: 140 IPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLP 199

Query: 218 QTV--DLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIP 275
           + V  D   +   GEW ++     +     +  +  Y ++ +  VIRR PLFY ++L++P
Sbjct: 200 EKVKSDRSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYVVSLLLP 258

Query: 276 CLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFT 335
            + +  + ++ FYLP + GE+++  I++LL  +VFL+++++ +P+T++  PLIG Y +  
Sbjct: 259 SIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVC 318

Query: 336 MIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNR 382
           M  + +S+  T+F++ + H+      +P W+R  +L  +  WLL  R
Sbjct: 319 MALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERI-AWLLCLR 364


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  204 bits (520), Expect = 1e-52
 Identities = 104/326 (31%), Positives = 184/326 (56%), Gaps = 7/326 (2%)

Query: 61  RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 120
           RL  +L   Y +  RPV +      V   + +  +++VDEKNQ++TT +W +Q W+D  L
Sbjct: 21  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 80

Query: 121 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 180
           +WNP DF NIT L +P++ IW+PDI++    D   +  ++   ++   G V    P    
Sbjct: 81  QWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKS-PNIPYVYIRHQGEVQNYKPLQVV 139

Query: 181 SSCSIDVTFFPFDQQNCKMKFGSW--TYDKAKIDLEQMEQTV--DLKDYWESGEWAIVNA 236
           ++CS+D+  FPFD QNC + F SW  T     I L ++ + V  D   +   GEW ++  
Sbjct: 140 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGV 199

Query: 237 TGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEK 296
              +     +  +  Y ++ +  VIRR PLFY ++L++P + +  + ++ FYLP + GE+
Sbjct: 200 LPYFREFSMES-SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGER 258

Query: 297 ITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRS 356
           ++  I++LL  +VFL+++++ +P+T++  PLIG Y +  M  + +S+  T+F++ + H+ 
Sbjct: 259 VSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQ 318

Query: 357 PSTHTMPHWVRGALLGCVPRWLLMNR 382
                +P W+R  +L  +  WLL  R
Sbjct: 319 DLQQPVPAWLRHLVLERI-AWLLCLR 343


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  197 bits (500), Expect = 3e-50
 Identities = 118/327 (36%), Positives = 168/327 (51%), Gaps = 44/327 (13%)

Query: 218 QTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCL 277
           Q  D+  Y  +GEW +V   G  + + Y+CC E YPDVT+   +RR  L+Y +NL+IPC+
Sbjct: 2   QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCV 61

Query: 278 LISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMI 337
           LIS L +LVF LP+D GEKI+L I+VLLSLTVF+LL+ EI+P+TS  +PLI +Y   TMI
Sbjct: 62  LISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMI 121

Query: 338 FVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKL 397
            V LS+V+TV VL  HH  P    MP W R  LL     +L M RP          +++ 
Sbjct: 122 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGED-------KVRP 174

Query: 398 SPSYHWLESNVDAEEREVVVEEEDRWACAGHV---------------APSVGTLCSH--- 439
           +  +     ++ + E   V       A  G++                P  G +C     
Sbjct: 175 ACQHKQRRCSLASVEMSAVAPPP---ASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMAC 231

Query: 440 -----GHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWK 494
                 HL  G   P+ +           P + K LE V YIA+  R +D   +V  +WK
Sbjct: 232 SPTHDEHLLHGGQPPEGD-----------PDLAKILEEVRYIANRFRCQDESEAVCSEWK 280

Query: 495 YVAMVIDRIFLWLFIIVCFLGTIGLFL 521
           + A V+DR+ L  F +   + TIG+ +
Sbjct: 281 FAACVVDRLCLMAFSVFTIICTIGILM 307


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  191 bits (484), Expect = 2e-48
 Identities = 109/379 (28%), Positives = 191/379 (50%), Gaps = 45/379 (11%)

Query: 46  PTALPQGGSHTETED------RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVD 99
           PT L QG +            RL  +L   Y +  RPV +      V   + +  +++VD
Sbjct: 21  PTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVD 80

Query: 100 EKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTH 159
           EKNQ++TT +W +Q W+D  L+WNP DF NIT L +P++ IW+PDI++    D   +  +
Sbjct: 81  EKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKS-PN 139

Query: 160 MTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSW--TYDKAKIDLEQME 217
           +   ++   G V    P    ++CS+D+  FPFD QNC + F SW  T     I L ++ 
Sbjct: 140 IPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLP 199

Query: 218 QTV--DLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIP 275
           + V  D   +   GEW ++     +     +  +  Y ++ +  VIRR PLFY ++L++P
Sbjct: 200 EKVKSDRSVFMNQGEWELLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLP 258

Query: 276 CLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGE----- 330
            + +  + ++ FYLP + GE+++  I++LL  +VFL+++++ +P+T++  PLIG+     
Sbjct: 259 SIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGS 318

Query: 331 ---------------------------YLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMP 363
                                      Y +  M  + +S+  T+F++ + H+      +P
Sbjct: 319 RAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVP 378

Query: 364 HWVRGALLGCVPRWLLMNR 382
            W+R  +L  +  WLL  R
Sbjct: 379 AWLRHLVLERI-AWLLCLR 396


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  159 bits (403), Expect = 5e-39
 Identities = 89/297 (29%), Positives = 153/297 (51%), Gaps = 7/297 (2%)

Query: 62  LFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLR 121
           L K L + Y++  RPV N +    V   L +  ++DVD +NQ++ T+VW ++ W+D  L 
Sbjct: 35  LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94

Query: 122 WNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKS 181
           WN + F  I  + +P   IW PDI++    D E     +   ++ S+GT+    P    S
Sbjct: 95  WNSSMFDEIREISLPLSAIWAPDIIINEFVDIE-RYPDLPYVYVNSSGTIENYKPIQVVS 153

Query: 182 SCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDL----KDYWESGEWAIVNAT 237
           +CS++   FPFD QNC + F S  +    +DL  +    D+    K +    EW +++ +
Sbjct: 154 ACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVS 213

Query: 238 GTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKI 297
            TY+       A  +  + +  V+RR PL Y ++L+IP + +  + +  FYLP +C  +I
Sbjct: 214 STYSI--LQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARI 271

Query: 298 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHH 354
               SVL+  TVF + ++  +P +    PLIG +    M F+ LS+  ++ ++   H
Sbjct: 272 VFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLH 328


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  158 bits (400), Expect = 1e-38
 Identities = 84/305 (27%), Positives = 161/305 (52%), Gaps = 11/305 (3%)

Query: 75  RPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLR 134
           RPV N S    V    +++ ++DV+E+  ++++ +WL+  W +  + WNP +   IT + 
Sbjct: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129

Query: 135 VPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQ 194
           + ++ +W+PDI +    D +     +T A++ + G + +  P    S C++D+ +FPFDQ
Sbjct: 130 MAAKNLWLPDIFIIELMDVDKTPKGLT-AYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188

Query: 195 QNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWES-----GEWAIVNATGTYNSKKYDCCA 249
           QNC + F S+ Y    + L+  ++  ++ D   +     GEW ++  +    + K     
Sbjct: 189 QNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKA--TAKLSRGG 246

Query: 250 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV 309
            +Y  + +   IRR P  Y INL++P   +  +  L FYLP   G ++   I++LL   V
Sbjct: 247 NLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNV 306

Query: 310 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN-VHHRSPSTHTMPHWVRG 368
           FLL++++++P++    PLIG Y    +  +  S++ T+F+ + +H  +     +P W+  
Sbjct: 307 FLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHS 364

Query: 369 ALLGC 373
            LL C
Sbjct: 365 LLLHC 369


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  152 bits (385), Expect = 6e-37
 Identities = 86/305 (28%), Positives = 153/305 (50%), Gaps = 11/305 (3%)

Query: 75  RPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLR 134
           RP  N S    V    +++ ++ VD + Q++T+ +W+   W +  + WNP +   I  L 
Sbjct: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114

Query: 135 VPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQ 194
           V +E +W+PDI +  + D +   + +T A++ S G + +  P    S C++D+ +FPFDQ
Sbjct: 115 VLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173

Query: 195 QNCKMKFGSWTYDKAKIDLEQMEQTVDLKD-----YWESGEWAIVNATGTYNSKKYDCCA 249
           QNC   F S+ Y    + L   ++  ++ D         GEW ++       + K     
Sbjct: 174 QNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKA--TPKMSMGN 231

Query: 250 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV 309
            +Y  + +   IRR P  Y INL++P   +  +  L FYLP++   +    I++LL   V
Sbjct: 232 NLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNV 291

Query: 310 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN-VHHRSPSTHTMPHWVRG 368
           FLL++ +++P++    PLI  Y    +  + +S++ TVF+   +H  +     MP W+  
Sbjct: 292 FLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHS 349

Query: 369 ALLGC 373
            LL C
Sbjct: 350 LLLHC 354


>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
           precursor [Homo sapiens]
          Length = 474

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 77/309 (24%), Positives = 135/309 (43%), Gaps = 36/309 (11%)

Query: 57  ETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWS 116
           ET DRL K    GY+   RP       V V   + +A +  V E N   T  ++ +Q W 
Sbjct: 39  ETVDRLLK----GYDIRLRP-DFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWK 93

Query: 117 DYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNN----ADGEFAVTHMTKAHLFSTGTVH 172
           D +L ++     N+T     ++ +W+PD    N+      G      M + H    GTV 
Sbjct: 94  DKRLSYSGIPL-NLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLH--PDGTVL 150

Query: 173 WVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWA 232
           +       ++C +D+  +P D+QNC ++  S+ Y            T D++ YW  GE A
Sbjct: 151 YGLRITTTAACMMDLRRYPLDEQNCTLEIESYGY-----------TTDDIEFYWNGGEGA 199

Query: 233 IVNATG-----------TYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISC 281
           +                   SKK +     YP ++ +F ++R   ++ +   +P  LI+ 
Sbjct: 200 VTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITI 259

Query: 282 LTVLVFYLPSDC-GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVT 340
           L+ + F++  D    ++ L I+ +L++T     + E +P    V   I  YL+   +FV 
Sbjct: 260 LSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYV-KAIDIYLMGCFVFVF 318

Query: 341 LSIVITVFV 349
           L+++   FV
Sbjct: 319 LALLEYAFV 327


>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
           [Homo sapiens]
          Length = 465

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 72/291 (24%), Positives = 134/291 (46%), Gaps = 18/291 (6%)

Query: 61  RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 120
           ++   L +GY+   RP       VI    + +  +  VD  N   T ++   Q W D +L
Sbjct: 66  QILNSLLQGYDNKLRPDIGVRPTVI-ETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRL 124

Query: 121 RWNPTDFGNITSLRVPSEM---IWIPDIVLYNN--ADGEFAVTHMTKAHLFSTGTVHWVP 175
           ++N T    +  L + S M   IWIPD    N+  +D  +  T      +++ G V +  
Sbjct: 125 KFNST----MKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL 180

Query: 176 PAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKD--YWESGEWAI 233
                + C + +  FP D+ +C ++F S+ Y K +I+ +  + +V++ D  YW   ++A 
Sbjct: 181 RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF 240

Query: 234 VNATGTYNSKKY-DCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSD 292
           V   G  NS +     +  Y  +T  F + R   ++TI   IPC+L   L+ + F++  D
Sbjct: 241 V---GLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKD 297

Query: 293 C-GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPL-IGEYLLFTMIFVTL 341
               + +L I+ +L++T    +  + +P  S V  + +   + F  +F  L
Sbjct: 298 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAAL 348


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 69/284 (24%), Positives = 125/284 (44%), Gaps = 14/284 (4%)

Query: 63  FKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRW 122
           F++L  GYN++ RP      V I    L IA +  + E N   T  ++L+Q W D +L +
Sbjct: 41  FENLTAGYNKFLRPNFGGEPVQIA-LTLDIASISSISESNMDYTATIYLRQRWMDQRLVF 99

Query: 123 NPTDFGNITSLRVPSEMIWIPDIVLYNNADG---EFAVTHMTKAHLFSTGTVHWVPPAIY 179
                  + +  V  E +W+PD  +  +      E  V +     LFS GTV +      
Sbjct: 100 EGNKSFTLDARLV--EFLWVPDTYIVESKKSFLHEVTVGNRL-IRLFSNGTVLYALRITT 156

Query: 180 KSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLK--DYWESGEWAIVNAT 237
             +C++D++ +P D Q CK++  SW YD   ++   +     ++  ++    ++ I    
Sbjct: 157 TVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYF 216

Query: 238 GTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKI 297
                 + +     Y  +   F +RR  L++ +   +P   +  L+ + F++  D     
Sbjct: 217 TLVTRSQQE--TGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPAR 274

Query: 298 TLCISV--LLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFV 339
           T CI V  +LS+T  ++     +P+T+  I  I  YL     FV
Sbjct: 275 T-CIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFV 317


>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 2 [Homo sapiens]
          Length = 474

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 74/304 (24%), Positives = 133/304 (43%), Gaps = 36/304 (11%)

Query: 57  ETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWS 116
           ET DRL K    GY+   RP       V V   + IA +  V E N   T  ++ +Q W 
Sbjct: 38  ETVDRLLK----GYDIRLRP-DFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWR 92

Query: 117 DYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNN----ADGEFAVTHMTKAHLFSTGTVH 172
           D +L +N     N+T     ++ +W+PD    N+      G      M + H    GTV 
Sbjct: 93  DKRLSYNVIPL-NLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLH--PDGTVL 149

Query: 173 WVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWA 232
           +       ++C +D+  +P D+QNC ++  S+ Y            T D++ YW   + A
Sbjct: 150 YGLRITTTAACMMDLRRYPLDEQNCTLEIESYGY-----------TTDDIEFYWRGDDNA 198

Query: 233 IVNATG-----------TYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISC 281
           +   T               +KK       YP ++ +F ++R   ++ +   +P +LI+ 
Sbjct: 199 VTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITI 258

Query: 282 LTVLVFYLPSDC-GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVT 340
           L+ + F++  D    ++ L I+ +L++T     + E +P    V   I  YL+   +FV 
Sbjct: 259 LSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYV-KAIDMYLMGCFVFVF 317

Query: 341 LSIV 344
           ++++
Sbjct: 318 MALL 321


>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 1 [Homo sapiens]
          Length = 512

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 74/304 (24%), Positives = 133/304 (43%), Gaps = 36/304 (11%)

Query: 57  ETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWS 116
           ET DRL K    GY+   RP       V V   + IA +  V E N   T  ++ +Q W 
Sbjct: 38  ETVDRLLK----GYDIRLRP-DFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWR 92

Query: 117 DYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNN----ADGEFAVTHMTKAHLFSTGTVH 172
           D +L +N     N+T     ++ +W+PD    N+      G      M + H    GTV 
Sbjct: 93  DKRLSYNVIPL-NLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLH--PDGTVL 149

Query: 173 WVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWA 232
           +       ++C +D+  +P D+QNC ++  S+ Y            T D++ YW   + A
Sbjct: 150 YGLRITTTAACMMDLRRYPLDEQNCTLEIESYGY-----------TTDDIEFYWRGDDNA 198

Query: 233 IVNATG-----------TYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISC 281
           +   T               +KK       YP ++ +F ++R   ++ +   +P +LI+ 
Sbjct: 199 VTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITI 258

Query: 282 LTVLVFYLPSDC-GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVT 340
           L+ + F++  D    ++ L I+ +L++T     + E +P    V   I  YL+   +FV 
Sbjct: 259 LSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYV-KAIDMYLMGCFVFVF 317

Query: 341 LSIV 344
           ++++
Sbjct: 318 MALL 321


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.453 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,337,301
Number of Sequences: 37866
Number of extensions: 1165861
Number of successful extensions: 5394
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 5172
Number of HSP's gapped (non-prelim): 171
length of query: 529
length of database: 18,247,518
effective HSP length: 107
effective length of query: 422
effective length of database: 14,195,856
effective search space: 5990651232
effective search space used: 5990651232
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.