BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo sapiens] (795 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 1587 0.0 gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 1002 0.0 gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 987 0.0 gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 985 0.0 gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 981 0.0 gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 971 0.0 gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 957 0.0 gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 940 0.0 gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 929 0.0 gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 926 0.0 gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 693 0.0 gi|193083131 MAP/microtubule affinity-regulating kinase 3 isofor... 522 e-148 gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 379 e-105 gi|116256471 SNF1-like kinase [Homo sapiens] 363 e-100 gi|38569460 SNF1-like kinase 2 [Homo sapiens] 351 2e-96 gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 283 4e-76 gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 278 1e-74 gi|156105707 SNF related kinase [Homo sapiens] 270 5e-72 gi|156105705 SNF related kinase [Homo sapiens] 270 5e-72 gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 267 3e-71 gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 266 7e-71 gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 256 8e-68 gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 255 1e-67 gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 252 8e-67 gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 249 5e-66 gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 244 2e-64 gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 233 4e-61 gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 195 2e-49 gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 191 3e-48 gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 182 8e-46 >gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo sapiens] Length = 795 Score = 1587 bits (4109), Expect = 0.0 Identities = 795/795 (100%), Positives = 795/795 (100%) Query: 1 MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY 60 MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY Sbjct: 1 MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY 60 Query: 61 RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV 120 RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV Sbjct: 61 RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV 120 Query: 121 KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH 180 KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH Sbjct: 121 KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH 180 Query: 181 RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV 240 RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV Sbjct: 181 RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV 240 Query: 241 WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG 300 WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG Sbjct: 241 WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG 300 Query: 301 SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE 360 SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE Sbjct: 301 SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE 360 Query: 361 VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQR 420 VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQR Sbjct: 361 VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQR 420 Query: 421 RFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP 480 RFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP Sbjct: 421 RFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP 480 Query: 481 ERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV 540 ERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV Sbjct: 481 ERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV 540 Query: 541 ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD 600 ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD Sbjct: 541 ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD 600 Query: 601 RTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKF 660 RTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKF Sbjct: 601 RTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKF 660 Query: 661 VRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMRE 720 VRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMRE Sbjct: 661 VRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMRE 720 Query: 721 IRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSI 780 IRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSI Sbjct: 721 IRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSI 780 Query: 781 AFKNIASKIANELKL 795 AFKNIASKIANELKL Sbjct: 781 AFKNIASKIANELKL 795 >gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d [Homo sapiens] Length = 788 Score = 1002 bits (2591), Expect = 0.0 Identities = 546/815 (66%), Positives = 636/815 (78%), Gaps = 50/815 (6%) Query: 2 SARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYR 61 SARTPLPT+NERDTE T G+ + +K SS+ N+ R RNS TSA DEQPHIGNYR Sbjct: 3 SARTPLPTLNERDTEQPTL--GHLD-----SKPSSKSNMIRGRNSATSA-DEQPHIGNYR 54 Query: 62 LQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 121 L KTIGKGNFAKVKLARH+LTG+EVAVKIIDKTQLN +SLQKLFREVRIMK+LNHPNIVK Sbjct: 55 LLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVK 114 Query: 122 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 181 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK+IVHR Sbjct: 115 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHR 174 Query: 182 DLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241 DLKAENLLLD DMNIKIADFGFSNEFT GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW Sbjct: 175 DLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234 Query: 242 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGS 301 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK L+LNP KRG+ Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294 Query: 302 LEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEV 361 LEQIMKDRWMNVGHE++ELKPY EP PD+ D +R ++MV+MG+ R+EI D+L+ Q+Y+EV Sbjct: 295 LEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEV 354 Query: 362 MATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRR 421 MATY+LLG K E EG + + RPS+DL NS+ SP+H KVQRS+SAN KQRR Sbjct: 355 MATYLLLGYKSSELEG------DTITLKPRPSADLTNSSAPSPSH-KVQRSVSANPKQRR 407 Query: 422 FSDH-AGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP 480 FSD AGP+IP + SY+K+ Q+N+ E+++ EE D++ RK ST +++ ASPL G Sbjct: 408 FSDQAAGPAIPTSNSYSKKTQSNNAENKRPEE-DRESGRKASST-----AKVPASPLPGL 461 Query: 481 ERKKSSTIPS-NNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSS 539 ERKK++ PS N+V S + RN+ + ER + ++QNGKDS S +S +SA Sbjct: 462 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASA--- 518 Query: 540 VASAVPSARPR-HQKSMSTSGHPIKVT-LPTIKDGSEAYRPGTT-QRVPAASPSAHSIST 596 ++AV +ARPR HQKSMS S HP K + LP + E RP T QRVP ASPSAH+IS+ Sbjct: 519 -SAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISS 577 Query: 597 A--TPDRTRFPRGSSSRSTFHGEQL---RERRSVAYNGPPASPSHETGAFAHARRGTSTG 651 + PDRT FPRG SSRSTFH QL R+++++ Y PASPS + RRG S Sbjct: 578 SGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS----GHSQGRRGASGS 633 Query: 652 IISKITSKFVRRDPS---------EGEASGRTDTSRS--TSGEPKERDKEEGKDSKPRSL 700 I SK TSKFVRR+ S E E+ R +T R +++KEE +++KPRSL Sbjct: 634 IFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSL 693 Query: 701 RFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVC 760 RFTWSMKTTSSM+PN+MMREIRKVLDAN+C E E+++L C+HG + VQWEMEVC Sbjct: 694 RFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVC 753 Query: 761 KLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 795 KLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL Sbjct: 754 KLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 788 >gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b [Homo sapiens] Length = 744 Score = 987 bits (2551), Expect = 0.0 Identities = 539/812 (66%), Positives = 604/812 (74%), Gaps = 85/812 (10%) Query: 1 MSARTPLPTVNERDTENHTSV-DGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGN 59 MS RTPLPTVNERDTENHTS DG E + ++S +R CRNSI S DEQPHIGN Sbjct: 1 MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGAR-----CRNSIASCADEQPHIGN 55 Query: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119 YRL KTIGKGNFAKVKLARH+LTGREVA+KIIDKTQLNPTSLQKLFREVRIMKILNHPNI Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115 Query: 120 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 179 VKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IV Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175 Query: 180 HRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD 239 HRDLKAENLLLD DMNIKIADFGFSNEFTVG KLDTFCGSPPYAAPELFQGKKYDGPEVD Sbjct: 176 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVD 235 Query: 240 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR 299 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+ LVLNPIKR Sbjct: 236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR 295 Query: 300 GSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYD 359 G+LEQIMKDRW+N GHEE+ELKP+ EP+ D +D KRIDIMV MG++++EI ++L KYD Sbjct: 296 GTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYD 355 Query: 360 EVMATYILLGRKPPEFEGGESLSSGNL-CQRSRPSSDLNNSTLQSPAHLKVQRSISANQK 418 E+ ATY+LLGRK E + +S SS NL + RPSSDLNNST QSP H KVQRS+ ++QK Sbjct: 356 EITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHH-KVQRSVFSSQK 414 Query: 419 QRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLV 478 QRR+SDHAGP+IP V+Y KR Q ++ +S+ KE D +RK + VG K ASP++ Sbjct: 415 QRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKE--DGISSRKSSGSAVGGKGIAPASPML 472 Query: 479 G----------PERKKSSTIPSNNVYSGGSMARRNTYVC-ERTT-DRYVALQNGKDSSLT 526 G PERKKSST+PS+N SGG M RRNTYVC ERTT DR+ +QNGK++S Sbjct: 473 GNASNPNKADIPERKKSSTVPSSNTASGG-MTRRNTYVCSERTTADRHSVIQNGKENSTI 531 Query: 527 EMSVSSISSAGSSVASAVPS--ARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRV 584 + ++S S ++A P PR S ST G R T Sbjct: 532 PDQRTPVASTHSISSAATPDRIRFPRGTASRSTF------------HGQPRERRTATYNG 579 Query: 585 PAASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHA 644 P ASPS SHE + Sbjct: 580 PPASPSL-------------------------------------------SHEATPLSQT 596 Query: 645 RRGTSTGIISKITSKFVRRDPSEGEASGRTD-TSRSTSGEPKERDKEEGKDSKPRSLRFT 703 R ST + SK+TSK RR P+E E +GR + +SR+ S E K+E K++KPRSLRFT Sbjct: 597 RSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSAE----QKDENKEAKPRSLRFT 652 Query: 704 WSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLP 763 WSMKTTSSMDP DMMREIRKVLDANNCDYEQ+ERFLLFCVHGD ++LVQWEMEVCKLP Sbjct: 653 WSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLP 712 Query: 764 RLSLNGVRFKRISGTSIAFKNIASKIANELKL 795 RLSLNGVRFKRISGTSIAFKNIASKIANELKL Sbjct: 713 RLSLNGVRFKRISGTSIAFKNIASKIANELKL 744 >gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens] Length = 745 Score = 985 bits (2546), Expect = 0.0 Identities = 525/765 (68%), Positives = 610/765 (79%), Gaps = 33/765 (4%) Query: 42 RCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL 101 R RNS TSA DEQPHIGNYRL KTIGKGNFAKVKLARH+LTG+EVAVKIIDKTQLN +SL Sbjct: 3 RGRNSATSA-DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61 Query: 102 QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 161 QKLFREVRIMK+LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA Sbjct: 62 QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121 Query: 162 KFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPP 221 KFRQIVSAVQYCHQK+IVHRDLKAENLLLD DMNIKIADFGFSNEFT GNKLDTFCGSPP Sbjct: 122 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPP 181 Query: 222 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 281 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS Sbjct: 182 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 241 Query: 282 TDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVT 341 TDCENLLKK L+LNP KRG+LEQIMKDRWMNVGHE++ELKPY EP PD+ D +R ++MV+ Sbjct: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS 301 Query: 342 MGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTL 401 MG+ R+EI D+L+ Q+Y+EVMATY+LLG K E EG + + RPS+DL NS+ Sbjct: 302 MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEG------DTITLKPRPSADLTNSSA 355 Query: 402 QSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKL 461 SP+H KVQRS+SAN KQRRFSD AGP+IP + SY+K+ Q+N+ E+++ EE D++ RK Sbjct: 356 PSPSH-KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEE-DRESGRKA 413 Query: 462 GSTTVGSKSEMTASPLVGPERKKSSTIPS-NNVYSGGSMARRNTYVCERTTDRYVALQNG 520 ST +++ ASPL G ERKK++ PS N+V S + RN+ + ER + ++QNG Sbjct: 414 SST-----AKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNG 468 Query: 521 KDSSLTEMSVSSISSAGSSVASAVPSARPR-HQKSMSTSGHPIKVT-LPTIKDGSEAYRP 578 KDS S +S +SA ++AV +ARPR HQKSMS S HP K + LP + E RP Sbjct: 469 KDSLTMPGSRASTASA----SAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRP 524 Query: 579 GTT-QRVPAASPSAHSISTA--TPDRTRFPRGSSSRSTFHGEQL---RERRSVAYNGPPA 632 T QRVP ASPSAH+IS++ PDRT FPRG SSRSTFH QL R+++++ Y PA Sbjct: 525 STAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPA 584 Query: 633 SPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTSRS--TSGEPKERDKE 690 SPS + RRG S I SK TSKFVRR+ +E E+ R +T R +++KE Sbjct: 585 SPS----GHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKE 640 Query: 691 EGKDSKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQD 750 E +++KPRSLRFTWSMKTTSSM+PN+MMREIRKVLDAN+C E E+++L C+HG + Sbjct: 641 EFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHE 700 Query: 751 SLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 795 VQWEMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL Sbjct: 701 DFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 745 >gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a [Homo sapiens] Length = 753 Score = 981 bits (2537), Expect = 0.0 Identities = 539/821 (65%), Positives = 606/821 (73%), Gaps = 94/821 (11%) Query: 1 MSARTPLPTVNERDTENHTSV-DGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGN 59 MS RTPLPTVNERDTENHTS DG E + ++S +R CRNSI S DEQPHIGN Sbjct: 1 MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGAR-----CRNSIASCADEQPHIGN 55 Query: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119 YRL KTIGKGNFAKVKLARH+LTGREVA+KIIDKTQLNPTSLQKLFREVRIMKILNHPNI Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115 Query: 120 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 179 VKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IV Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175 Query: 180 HRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD 239 HRDLKAENLLLD DMNIKIADFGFSNEFTVG KLDTFCGSPPYAAPELFQGKKYDGPEVD Sbjct: 176 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVD 235 Query: 240 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR 299 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+ LVLNPIKR Sbjct: 236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR 295 Query: 300 GSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYD 359 G+LEQIMKDRW+N GHEE+ELKP+ EP+ D +D KRIDIMV MG++++EI ++L KYD Sbjct: 296 GTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYD 355 Query: 360 EVMATYILLGRKPPEFEGGESLSSGNL-CQRSRPSSDLNNSTLQSPAHLKVQRSISANQK 418 E+ ATY+LLGRK E + +S SS NL + RPSSDLNNST QSP H KVQRS+ ++QK Sbjct: 356 EITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHH-KVQRSVFSSQK 414 Query: 419 QRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLV 478 QRR+SDHAGP+IP V+Y KR Q ++ +S+ KE D +RK + VG K ASP++ Sbjct: 415 QRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKE--DGISSRKSSGSAVGGKGIAPASPML 472 Query: 479 G----------PERKKSSTIPSNNVYSGGSMARRNTYVC-ERTT-DRYVALQNGKDSSLT 526 G PERKKSST+PS+N SGG M RRNTYVC ERTT DR+ +QNGK++S Sbjct: 473 GNASNPNKADIPERKKSSTVPSSNTASGG-MTRRNTYVCSERTTADRHSVIQNGKENSTI 531 Query: 527 EMSVSSISSAGSSVASAVPS--ARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRV 584 + ++S S ++A P PR S ST G R T Sbjct: 532 PDQRTPVASTHSISSAATPDRIRFPRGTASRSTF------------HGQPRERRTATYNG 579 Query: 585 PAASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHA 644 P ASPS SHE + Sbjct: 580 PPASPSL-------------------------------------------SHEATPLSQT 596 Query: 645 RRGTSTGIISKITSK---------FVRRDPSEGEASGRTD-TSRSTSGEPKERDKEEGKD 694 R ST + SK+TSK F++R P+E E +GR + +SR+ S E K+E K+ Sbjct: 597 RSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAE----QKDENKE 652 Query: 695 SKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQ 754 +KPRSLRFTWSMKTTSSMDP DMMREIRKVLDANNCDYEQ+ERFLLFCVHGD ++LVQ Sbjct: 653 AKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQ 712 Query: 755 WEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 795 WEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL Sbjct: 713 WEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753 >gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c [Homo sapiens] Length = 729 Score = 971 bits (2510), Expect = 0.0 Identities = 533/811 (65%), Positives = 594/811 (73%), Gaps = 98/811 (12%) Query: 1 MSARTPLPTVNERDTENHTSV-DGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGN 59 MS RTPLPTVNERDTENHTS DG E + ++S +R CRNSI S DEQPHIGN Sbjct: 1 MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGAR-----CRNSIASCADEQPHIGN 55 Query: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119 YRL KTIGKGNFAKVKLARH+LTGREVA+KIIDKTQLNPTSLQKLFREVRIMKILNHPNI Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115 Query: 120 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 179 VKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IV Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175 Query: 180 HRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD 239 HRDLKAENLLLD DMNIKIADFGFSNEFTVG KLDTFCGSPPYAAPELFQGKKYDGPEVD Sbjct: 176 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVD 235 Query: 240 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR 299 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+ LVLNPIKR Sbjct: 236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR 295 Query: 300 GSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYD 359 G+LEQIMKDRW+N GHEE+ELKP+ EP+ D +D KRIDIMV MG++++EI ++L KYD Sbjct: 296 GTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYD 355 Query: 360 EVMATYILLGRKPPEFEGGESLSSGNL-CQRSRPSSDLNNSTLQSPAHLKVQRSISANQK 418 E+ ATY+LLGRK E + +S SS NL + RPSSDLNNST QSP H KVQRS+ ++QK Sbjct: 356 EITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHH-KVQRSVFSSQK 414 Query: 419 QRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLV 478 QRR+SDHAGP+IP V+Y KR Q ++ +S+ KE D +RK + VG K ASP++ Sbjct: 415 QRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKE--DGISSRKSSGSAVGGKGIAPASPML 472 Query: 479 G----------PERKKSSTIPSNNVYSGGSMARRNTYVC-ERTT-DRYVALQNGKDSSLT 526 G PERKKSST+PS+N SGG M RRNTYVC ERTT DR+ +QNGK++S Sbjct: 473 GNASNPNKADIPERKKSSTVPSSNTASGG-MTRRNTYVCSERTTADRHSVIQNGKENSTI 531 Query: 527 EMSVSSISSAGSSVASAVPS--ARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRV 584 + ++S S ++A P PR S ST G R T Sbjct: 532 PDQRTPVASTHSISSAATPDRIRFPRGTASRSTF------------HGQPRERRTATYNG 579 Query: 585 PAASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHA 644 P ASPS SHE + Sbjct: 580 PPASPSL-------------------------------------------SHEATPLSQT 596 Query: 645 RRGTSTGIISKITSKFVRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTW 704 R ST + SK+TSK R SR+ S E K+E K++KPRSLRFTW Sbjct: 597 RSRGSTNLFSKLTSKLTR--------------SRNVSAE----QKDENKEAKPRSLRFTW 638 Query: 705 SMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPR 764 SMKTTSSMDP DMMREIRKVLDANNCDYEQ+ERFLLFCVHGD ++LVQWEMEVCKLPR Sbjct: 639 SMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPR 698 Query: 765 LSLNGVRFKRISGTSIAFKNIASKIANELKL 795 LSLNGVRFKRISGTSIAFKNIASKIANELKL Sbjct: 699 LSLNGVRFKRISGTSIAFKNIASKIANELKL 729 >gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d [Homo sapiens] Length = 713 Score = 957 bits (2473), Expect = 0.0 Identities = 528/810 (65%), Positives = 586/810 (72%), Gaps = 112/810 (13%) Query: 1 MSARTPLPTVNERDTENHTSV-DGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGN 59 MS RTPLPTVNERDTENHTS DG E + ++S +R CRNSI S DEQPHIGN Sbjct: 1 MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGAR-----CRNSIASCADEQPHIGN 55 Query: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119 YRL KTIGKGNFAKVKLARH+LTGREVA+KIIDKTQLNPTSLQKLFREVRIMKILNHPNI Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115 Query: 120 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 179 VKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IV Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175 Query: 180 HRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD 239 HRDLKAENLLLD DMNIKIADFGFSNEFTVG KLDTFCGSPPYAAPELFQGKKYDGPEVD Sbjct: 176 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVD 235 Query: 240 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR 299 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+ LVLNPIKR Sbjct: 236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR 295 Query: 300 GSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYD 359 G+LEQIMKDRW+N GHEE+ELKP+ EP+ D +D KRIDIMV MG++++EI ++L KYD Sbjct: 296 GTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYD 355 Query: 360 EVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQ 419 E+ ATY+LLGRK E RPSSDLNNST QSP H KVQRS+ ++QKQ Sbjct: 356 EITATYLLLGRKSSEV---------------RPSSDLNNSTGQSPHH-KVQRSVFSSQKQ 399 Query: 420 RRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVG 479 RR+SDHAGP+IP V+Y KR Q ++ +S+ KE D +RK + VG K ASP++G Sbjct: 400 RRYSDHAGPAIPSVVAYPKRSQTSTADSDLKE--DGISSRKSSGSAVGGKGIAPASPMLG 457 Query: 480 ----------PERKKSSTIPSNNVYSGGSMARRNTYVC-ERTT-DRYVALQNGKDSSLTE 527 PERKKSST+PS+N SGG M RRNTYVC ERTT DR+ +QNGK++S Sbjct: 458 NASNPNKADIPERKKSSTVPSSNTASGG-MTRRNTYVCSERTTADRHSVIQNGKENSTIP 516 Query: 528 MSVSSISSAGSSVASAVPS--ARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVP 585 + ++S S ++A P PR S ST G R T P Sbjct: 517 DQRTPVASTHSISSAATPDRIRFPRGTASRSTF------------HGQPRERRTATYNGP 564 Query: 586 AASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHAR 645 ASPS SHE + R Sbjct: 565 PASPSL-------------------------------------------SHEATPLSQTR 581 Query: 646 RGTSTGIISKITSKFVRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWS 705 ST + SK+TSK R SR+ S E K+E K++KPRSLRFTWS Sbjct: 582 SRGSTNLFSKLTSKLTR--------------SRNVSAE----QKDENKEAKPRSLRFTWS 623 Query: 706 MKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRL 765 MKTTSSMDP DMMREIRKVLDANNCDYEQ+ERFLLFCVHGD ++LVQWEMEVCKLPRL Sbjct: 624 MKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRL 683 Query: 766 SLNGVRFKRISGTSIAFKNIASKIANELKL 795 SLNGVRFKRISGTSIAFKNIASKIANELKL Sbjct: 684 SLNGVRFKRISGTSIAFKNIASKIANELKL 713 >gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c [Homo sapiens] Length = 724 Score = 940 bits (2430), Expect = 0.0 Identities = 509/800 (63%), Positives = 594/800 (74%), Gaps = 84/800 (10%) Query: 2 SARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYR 61 SARTPLPT+NERDTE T G+ + +K SS+ N+ R RNS TSA DEQPHIGNYR Sbjct: 3 SARTPLPTLNERDTEQPTL--GHLD-----SKPSSKSNMIRGRNSATSA-DEQPHIGNYR 54 Query: 62 LQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 121 L KTIGKGNFAKVKLARH+LTG+EVAVKIIDKTQLN +SLQKLFREVRIMK+LNHPNIVK Sbjct: 55 LLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVK 114 Query: 122 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 181 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK+IVHR Sbjct: 115 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHR 174 Query: 182 DLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241 DLKAENLLLD DMNIKIADFGFSNEFT GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW Sbjct: 175 DLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234 Query: 242 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGS 301 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK L+LNP KRG+ Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294 Query: 302 LEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEV 361 LEQIMKDRWMNVGHE++ELKPY EP PD+ D +R ++MV+MG+ R+EI D+L+ Q+Y+EV Sbjct: 295 LEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEV 354 Query: 362 MATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRR 421 MATY+LLG K E EG + + RPS+DL NS+ SP+H KVQRS+SAN KQRR Sbjct: 355 MATYLLLGYKSSELEG------DTITLKPRPSADLTNSSAPSPSH-KVQRSVSANPKQRR 407 Query: 422 FSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGPE 481 FSD AGP+IP + SY+K+ Q+N+ E+++ EE D++ RK ST +++ ASPL G E Sbjct: 408 FSDQAGPAIPTSNSYSKKTQSNNAENKRPEE-DRESGRKASST-----AKVPASPLPGLE 461 Query: 482 RKKSSTIPS-NNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV 540 RKK++ PS N+V S + RN+ + ER + ++QNGKDS+ + Sbjct: 462 RKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQ------------- 508 Query: 541 ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD 600 VP A P S+ G P + P Sbjct: 509 --RVPVASPSAHNISSSGGAPDRTNFP--------------------------------- 533 Query: 601 RTRFPRGSSSRSTFHGEQL---RERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKIT 657 RG SSRSTFH QL R+++++ Y PASPS + RRG S I SK T Sbjct: 534 -----RGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS----GHSQGRRGASGSIFSKFT 584 Query: 658 SKFVRRDPSEGEASGRTDTSRS--TSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPN 715 SKFVRR+ +E E+ R +T R +++KEE +++KPRSLRFTWSMKTTSSM+PN Sbjct: 585 SKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPN 644 Query: 716 DMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRI 775 +MMREIRKVLDAN+C E E+++L C+HG + VQWEMEVCKLPRLSLNGVRFKRI Sbjct: 645 EMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRI 704 Query: 776 SGTSIAFKNIASKIANELKL 795 SGTS+AFKNIASKIANELKL Sbjct: 705 SGTSMAFKNIASKIANELKL 724 >gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f [Homo sapiens] Length = 709 Score = 929 bits (2402), Expect = 0.0 Identities = 508/798 (63%), Positives = 588/798 (73%), Gaps = 95/798 (11%) Query: 2 SARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYR 61 SARTPLPT+NERDTE T G+ + +K SS+ N+ R RNS TSA DEQPHIGNYR Sbjct: 3 SARTPLPTLNERDTEQPTL--GHLD-----SKPSSKSNMIRGRNSATSA-DEQPHIGNYR 54 Query: 62 LQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 121 L KTIGKGNFAKVKLARH+LTG+EVAVKIIDKTQLN +SLQKLFREVRIMK+LNHPNIVK Sbjct: 55 LLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVK 114 Query: 122 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 181 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK+IVHR Sbjct: 115 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHR 174 Query: 182 DLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241 DLKAENLLLD DMNIKIADFGFSNEFT GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW Sbjct: 175 DLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234 Query: 242 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGS 301 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK L+LNP KRG+ Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294 Query: 302 LEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEV 361 LEQIMKDRWMNVGHE++ELKPY EP PD+ D +R ++MV+MG+ R+EI D+L+ Q+Y+EV Sbjct: 295 LEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEV 354 Query: 362 MATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRR 421 MATY+LLG K E EG + + RPS+DL NS+ SP+H KVQRS+SAN KQRR Sbjct: 355 MATYLLLGYKSSELEG------DTITLKPRPSADLTNSSAPSPSH-KVQRSVSANPKQRR 407 Query: 422 FSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGPE 481 FSD AGP+IP + SY+K+ Q+N+ E+++ EE D++ RK ST +++ ASPL G E Sbjct: 408 FSDQAGPAIPTSNSYSKKTQSNNAENKRPEE-DRESGRKASST-----AKVPASPLPGLE 461 Query: 482 RKKSSTIPS-NNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV 540 RKK++ PS N+V S + RN+ + ER + ++QNGKDS+ + Sbjct: 462 RKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQ------------- 508 Query: 541 ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD 600 VP A P S+ G P + P Sbjct: 509 --RVPVASPSAHNISSSGGAPDRTNFP--------------------------------- 533 Query: 601 RTRFPRGSSSRSTFHGEQL---RERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKIT 657 RG SSRSTFH QL R+++++ Y PASPS + RRG S I SK T Sbjct: 534 -----RGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS----GHSQGRRGASGSIFSKFT 584 Query: 658 SKFVRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDM 717 SKFVRR G SG D ++KEE +++KPRSLRFTWSMKTTSSM+PN+M Sbjct: 585 SKFVRRPHVVG--SGGND-----------KEKEEFREAKPRSLRFTWSMKTTSSMEPNEM 631 Query: 718 MREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISG 777 MREIRKVLDAN+C E E+++L C+HG + VQWEMEVCKLPRLSLNGVRFKRISG Sbjct: 632 MREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISG 691 Query: 778 TSIAFKNIASKIANELKL 795 TS+AFKNIASKIANELKL Sbjct: 692 TSMAFKNIASKIANELKL 709 >gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e [Homo sapiens] Length = 719 Score = 926 bits (2392), Expect = 0.0 Identities = 510/799 (63%), Positives = 590/799 (73%), Gaps = 87/799 (10%) Query: 2 SARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYR 61 SARTPLPT+NERDTE T G+ + +K SS+ N+ R RNS TSA DEQPHIGNYR Sbjct: 3 SARTPLPTLNERDTEQPTL--GHLD-----SKPSSKSNMIRGRNSATSA-DEQPHIGNYR 54 Query: 62 LQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 121 L KTIGKGNFAKVKLARH+LTG+EVAVKIIDKTQLN +SLQKLFREVRIMK+LNHPNIVK Sbjct: 55 LLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVK 114 Query: 122 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 181 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK+IVHR Sbjct: 115 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHR 174 Query: 182 DLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241 DLKAENLLLD DMNIKIADFGFSNEFT GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW Sbjct: 175 DLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234 Query: 242 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGS 301 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK L+LNP KRG+ Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294 Query: 302 LEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEV 361 LEQIMKDRWMNVGHE++ELKPY EP PD+ D +R ++MV+MG+ R+EI D+L+ Q+Y+EV Sbjct: 295 LEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEV 354 Query: 362 MATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRR 421 MATY+LLG K E EG + + RPS+DL NS+ SP+H KVQRS+SAN KQRR Sbjct: 355 MATYLLLGYKSSELEG------DTITLKPRPSADLTNSSAPSPSH-KVQRSVSANPKQRR 407 Query: 422 FSDH-AGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP 480 FSD AGP+IP + SY+K+ Q+N+ E+++ EE D++ RK ST +++ ASPL G Sbjct: 408 FSDQAAGPAIPTSNSYSKKTQSNNAENKRPEE-DRESGRKASST-----AKVPASPLPGL 461 Query: 481 ERKKSSTIPS-NNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSS 539 ERKK++ PS N+V S + RN+ + ER + ++QNGKDS+ + Sbjct: 462 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQ------------ 509 Query: 540 VASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATP 599 VP A P S+ G P + P Sbjct: 510 ---RVPVASPSAHNISSSGGAPDRTNFP-------------------------------- 534 Query: 600 DRTRFPRGSSSRSTFHGEQL---RERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKI 656 RG SSRSTFH QL R+++++ Y PASPS + RRG S I SK Sbjct: 535 ------RGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS----GHSQGRRGASGSIFSKF 584 Query: 657 TSKFVRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPND 716 TSKFVRR+ S A R + G KE KEE +++KPRSLRFTWSMKTTSSM+PN+ Sbjct: 585 TSKFVRRNLSFRFA--RRPHVVGSGGNDKE--KEEFREAKPRSLRFTWSMKTTSSMEPNE 640 Query: 717 MMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRIS 776 MMREIRKVLDAN+C E E+++L C+HG + VQWEMEVCKLPRLSLNGVRFKRIS Sbjct: 641 MMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRIS 700 Query: 777 GTSIAFKNIASKIANELKL 795 GTS+AFKNIASKIANELKL Sbjct: 701 GTSMAFKNIASKIANELKL 719 >gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo sapiens] Length = 688 Score = 693 bits (1788), Expect = 0.0 Identities = 405/723 (56%), Positives = 480/723 (66%), Gaps = 90/723 (12%) Query: 1 MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY 60 MS+RT L N+R+++ H ++ P+ SS R RCRNSI S +EQPH+GNY Sbjct: 1 MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSS-RSLGARCRNSIASCPEEQPHVGNY 59 Query: 61 RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV 120 RL +TIGKGNFAKVKLARH+LTGREVA+KIIDKTQLNP+SLQKLFREVRIMK LNHPNIV Sbjct: 60 RLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIV 119 Query: 121 KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH 180 KLFEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARAKFRQIVSAV YCHQK IVH Sbjct: 120 KLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVH 179 Query: 181 RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV 240 RDLKAENLLLD + NIKIADFGFSNEFT+G+KLDTFCGSPPYAAPELFQGKKYDGPEVD+ Sbjct: 180 RDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDI 239 Query: 241 WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG 300 WSLGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L++ LVLNP KR Sbjct: 240 WSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRC 299 Query: 301 SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE 360 +LEQIMKD+W+N+G+E EELKPYTEP+ DF DTKRI++MV MG+ R+EI ++L +QKY+E Sbjct: 300 TLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNE 359 Query: 361 VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQS--PAHLKVQRSISAN-Q 417 V ATY+LLGRK EGG+ + G R R SD N T S +H K QRS S+ Sbjct: 360 VTATYLLLGRKTE--EGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYH 417 Query: 418 KQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSE--MTAS 475 +QRR SD GPS PA + KR ++ E+E KEE + RK +T GS S +S Sbjct: 418 RQRRHSDFCGPS--PAPLHPKRSPTSTGEAELKEE--RLPGRKASCSTAGSGSRGLPPSS 473 Query: 476 PLVG----------PERKKSSTIPSNNVYSGGSMARRNTYVCERT--TDRYVALQNGKDS 523 P+V PER+K ST NN+ M RRNTYVC +R L NGK++ Sbjct: 474 PMVSSAHNPNKAEIPERRKDSTSTPNNL-PPSMMTRRNTYVCTERPGAERPSLLPNGKEN 532 Query: 524 SLTEMSVSSISSAGSSVASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQR 583 SS VP A P S H + Sbjct: 533 --------------SSGTPRVPPASP--------SSHSL--------------------- 549 Query: 584 VPAASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRS------VAYNGPPASP--S 635 A PS +R+R RGS+ RSTFHG Q+R+RR+ NGPPASP + Sbjct: 550 ---APPSG--------ERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLA 598 Query: 636 HETGAFAHARRGTSTGIISKITSKFVRR---DPSEGEASGRTDTSRSTSGEPKERDKEEG 692 HE R +T + +K+TSK RR DPS+ + S R + S K R + Sbjct: 599 HEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTNL 658 Query: 693 KDS 695 ++S Sbjct: 659 RES 661 >gi|193083131 MAP/microtubule affinity-regulating kinase 3 isoform e [Homo sapiens] Length = 659 Score = 522 bits (1345), Expect = e-148 Identities = 304/551 (55%), Positives = 360/551 (65%), Gaps = 83/551 (15%) Query: 260 QNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEE 319 ++LKELRERVLRGKYRIPFYMSTDCENLLK+ LVLNPIKRG+LEQIMKDRW+N GHEE+E Sbjct: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236 Query: 320 LKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGE 379 LKP+ EP+ D +D KRIDIMV MG++++EI ++L KYDE+ ATY+LLGRK E + + Sbjct: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296 Query: 380 SLSSGNL-CQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTK 438 S SS NL + RPSSDLNNST QSP H KVQRS+ ++QKQRR+SDHAGP+IP V+Y K Sbjct: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHH-KVQRSVFSSQKQRRYSDHAGPAIPSVVAYPK 355 Query: 439 RPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVG----------PERKKSSTI 488 R Q ++ +S+ KE D +RK + VG K ASP++G PERKKSST+ Sbjct: 356 RSQTSTADSDLKE--DGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTV 413 Query: 489 PSNNVYSGGSMARRNTYVC-ERTT-DRYVALQNGKDSSLTEMSVSSISSAGSSVASAVPS 546 PS+N SGG M RRNTYVC ERTT DR+ +QNGK++S + ++S S ++A P Sbjct: 414 PSSNTASGG-MTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPD 472 Query: 547 --ARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPDRTRF 604 PR S ST G R T P ASPS Sbjct: 473 RIRFPRGTASRSTF------------HGQPRERRTATYNGPPASPSL------------- 507 Query: 605 PRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRRD 664 SHE + R ST + SK+TSK RR+ Sbjct: 508 ------------------------------SHEATPLSQTRSRGSTNLFSKLTSKLTRRN 537 Query: 665 PSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMREIRKV 724 S R SR+ S E K+E K++KPRSLRFTWSMKTTSSMDP DMMREIRKV Sbjct: 538 -----MSFRFIKSRNVSAE----QKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKV 588 Query: 725 LDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKN 784 LDANNCDYEQ+ERFLLFCVHGD ++LVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKN Sbjct: 589 LDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKN 648 Query: 785 IASKIANELKL 795 IASKIANELKL Sbjct: 649 IASKIANELKL 659 Score = 305 bits (781), Expect = 1e-82 Identities = 157/185 (84%), Positives = 165/185 (89%), Gaps = 6/185 (3%) Query: 1 MSARTPLPTVNERDTENHTSV-DGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGN 59 MS RTPLPTVNERDTENHTS DG E + ++S +R CRNSI S DEQPHIGN Sbjct: 1 MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGAR-----CRNSIASCADEQPHIGN 55 Query: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119 YRL KTIGKGNFAKVKLARH+LTGREVA+KIIDKTQLNPTSLQKLFREVRIMKILNHPNI Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115 Query: 120 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 179 VKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IV Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175 Query: 180 HRDLK 184 HRDLK Sbjct: 176 HRDLK 180 >gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] Length = 1263 Score = 379 bits (973), Expect = e-105 Identities = 190/322 (59%), Positives = 246/322 (76%), Gaps = 12/322 (3%) Query: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNH 116 IG Y + +TIGKGNFA VK A H++T +VA+KIIDKTQL+ +L+K+FREV+IMK+L H Sbjct: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64 Query: 117 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 176 P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH + Sbjct: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124 Query: 177 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGP 236 IVHRDLKAENLLLD ++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP Sbjct: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184 Query: 237 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 296 +VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ +LVL+P Sbjct: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244 Query: 297 IKRGSLEQIMKDRWMNVGH----------EEEELKPYTEPDPDFNDTKRIDIMVTMGFAR 346 KR S+EQI K +WM +G E ++LK + DP D + M MG + Sbjct: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDV--LLAMEDMGLDK 302 Query: 347 DEINDALINQKYDEVMATYILL 368 ++ +L + YD A Y LL Sbjct: 303 EQTLQSLRSDAYDHYSAIYSLL 324 >gi|116256471 SNF1-like kinase [Homo sapiens] Length = 783 Score = 363 bits (931), Expect = e-100 Identities = 177/348 (50%), Positives = 249/348 (71%), Gaps = 8/348 (2%) Query: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNH 116 +G Y +++T+GKGNFA VKLARH +T +VA+KIIDKT+L+ ++L+K++REV++MK+LNH Sbjct: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83 Query: 117 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 176 P+I+KL++V+ET+ LY+V E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH Sbjct: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143 Query: 177 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGP 236 +IVHRDLK ENLLLDG+M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP Sbjct: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203 Query: 237 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 296 ++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L++++LV++P Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263 Query: 297 IKRGSLEQIMKDRWMNV-------GHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEI 349 +R ++ QI + RWM YT D+ D + + IM T+G R Sbjct: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322 Query: 350 NDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLN 397 ++L N Y+ A Y LL + E+ + G Q SSDL+ Sbjct: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLS 370 >gi|38569460 SNF1-like kinase 2 [Homo sapiens] Length = 926 Score = 351 bits (900), Expect = 2e-96 Identities = 170/319 (53%), Positives = 237/319 (74%), Gaps = 9/319 (2%) Query: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNH 116 +G Y ++ T+GKGNFA VKL RH +T EVA+KIIDK+QL+ +L+K++REV+IMK+L+H Sbjct: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76 Query: 117 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 176 P+I+KL++V+ET+ LYLV EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH + Sbjct: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136 Query: 177 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGP 236 IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP Sbjct: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196 Query: 237 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 296 ++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L++++LVL+P Sbjct: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256 Query: 297 IKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFND-------TKRIDIMVTMGFARDEI 349 KR ++ QI + +WM + E +P P N+ + + +M ++G + + Sbjct: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314 Query: 350 NDALINQKYDEVMATYILL 368 ++L N+ Y+ A Y LL Sbjct: 315 IESLQNKSYNHFAAIYFLL 333 >gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] Length = 778 Score = 283 bits (724), Expect = 4e-76 Identities = 149/331 (45%), Positives = 213/331 (64%), Gaps = 17/331 (5%) Query: 56 HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILN 115 ++G YRL+KT+GKG VKL H +TG++VA+KI+++ +L+ + L K+ RE+ I+K++ Sbjct: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89 Query: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 175 HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH Sbjct: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149 Query: 176 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235 I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G+KYDG Sbjct: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209 Query: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 295 D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ ++ + Sbjct: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269 Query: 296 PIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFN------------DTKRIDIMVTMG 343 P KR SLEQI K W G E + P EP P D ++ M ++G Sbjct: 270 PEKRLSLEQIQKHPWYLGGKHEPD--PCLEPAPGRRVAMRSLPSNGELDPDVLESMASLG 327 Query: 344 FARDE---INDALINQKYDEVMATYILLGRK 371 RD + ++ E M Y+LL RK Sbjct: 328 CFRDRERLHRELRSEEENQEKMIYYLLLDRK 358 >gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] Length = 668 Score = 278 bits (711), Expect = 1e-74 Identities = 144/327 (44%), Positives = 215/327 (65%), Gaps = 11/327 (3%) Query: 56 HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILN 115 ++G YRL+KT+GKG VKL H +T ++VA+KI+++ +L+ + L K+ RE+ I+K++ Sbjct: 15 YVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIE 74 Query: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 175 HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQI+SA+ +CH Sbjct: 75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 134 Query: 176 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235 I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G+KYDG Sbjct: 135 HSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194 Query: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 295 + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ ++ ++ Sbjct: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254 Query: 296 PIKRGSLEQIMKDRWMNVGHEEEE--------LKPYTEPDPDFNDTKRIDIMVTMGFARD 347 +R +LE I K W G E E ++ + P + D +D M ++G RD Sbjct: 255 AARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRD 314 Query: 348 E---INDALINQKYDEVMATYILLGRK 371 + D L ++ E M ++LL RK Sbjct: 315 RNKLLQDLLSEEENQEKMIYFLLLDRK 341 >gi|156105707 SNF related kinase [Homo sapiens] Length = 765 Score = 270 bits (689), Expect = 5e-72 Identities = 171/444 (38%), Positives = 251/444 (56%), Gaps = 47/444 (10%) Query: 58 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 117 G Y L KT+G+G+FA VKLARHV TG +VAVK+IDKT+L+ + LF+EVR MK++ HP Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73 Query: 118 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 176 NIV+L+EVI+T+ LYL++E GG++FDY++ H + E A+ F QIV A+ YCH+ Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133 Query: 177 YIVHRDLKAENLL-LDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235 ++VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193 Query: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 295 P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ ++L + Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253 Query: 296 PIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKR------IDIMVTMGFA-RDE 348 P +R SLE+I W+ G + Y P + + I MV A RD Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312 Query: 349 INDALINQKYDEVMATYILLG----RKPPEFE-GGESLSSGNLCQRSRPS---------- 393 I +AL +Y+ + ATY LL R+ E E S S N+ + R S Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372 Query: 394 -------SDLNNSTL-QSPAH-----LKVQRS--ISANQKQRRFSDHAGPSIPPAVSYTK 438 + L+++T+ QSPA L RS + + K+ + AGP++ + Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432 Query: 439 RPQANS-------VESEQKEEWDK 455 +P A+ E E+++E DK Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDK 456 >gi|156105705 SNF related kinase [Homo sapiens] Length = 765 Score = 270 bits (689), Expect = 5e-72 Identities = 171/444 (38%), Positives = 251/444 (56%), Gaps = 47/444 (10%) Query: 58 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 117 G Y L KT+G+G+FA VKLARHV TG +VAVK+IDKT+L+ + LF+EVR MK++ HP Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73 Query: 118 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 176 NIV+L+EVI+T+ LYL++E GG++FDY++ H + E A+ F QIV A+ YCH+ Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133 Query: 177 YIVHRDLKAENLL-LDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235 ++VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193 Query: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 295 P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ ++L + Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253 Query: 296 PIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKR------IDIMVTMGFA-RDE 348 P +R SLE+I W+ G + Y P + + I MV A RD Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312 Query: 349 INDALINQKYDEVMATYILLG----RKPPEFE-GGESLSSGNLCQRSRPS---------- 393 I +AL +Y+ + ATY LL R+ E E S S N+ + R S Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372 Query: 394 -------SDLNNSTL-QSPAH-----LKVQRS--ISANQKQRRFSDHAGPSIPPAVSYTK 438 + L+++T+ QSPA L RS + + K+ + AGP++ + Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432 Query: 439 RPQANS-------VESEQKEEWDK 455 +P A+ E E+++E DK Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDK 456 >gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens] Length = 552 Score = 267 bits (682), Expect = 3e-71 Identities = 132/287 (45%), Positives = 190/287 (66%), Gaps = 6/287 (2%) Query: 52 DEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRI 110 D + IG+Y L T+G G F KVK+ H LTG +VAVKI+++ ++ + K+ RE++ Sbjct: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 Query: 111 MKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 170 +K+ HP+I+KL++VI T ++VMEY SGGE+FDY+ HGR++E EAR F+QI+SAV Sbjct: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 Query: 171 QYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQG 230 YCH+ +VHRDLK EN+LLD MN KIADFG SN + G L T CGSP YAAPE+ G Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 Query: 231 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 290 + Y GPEVD+WS GVILY L+ G+LPFD +++ L +++ G + IP Y++ LL Sbjct: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247 Query: 291 LLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRID 337 +L ++P+KR +++ I + W +++L Y P+ D ID Sbjct: 248 MLQVDPLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVID 289 >gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 1 [Homo sapiens] Length = 559 Score = 266 bits (679), Expect = 7e-71 Identities = 146/386 (37%), Positives = 229/386 (59%), Gaps = 19/386 (4%) Query: 52 DEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRI 110 D + IG+Y L T+G G F KVK+ +H LTG +VAVKI+++ ++ + K+ RE++ Sbjct: 19 DGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQN 78 Query: 111 MKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 170 +K+ HP+I+KL++VI T +++VMEY SGGE+FDY+ +GR+ EKE+R F+QI+S V Sbjct: 79 LKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 138 Query: 171 QYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQG 230 YCH+ +VHRDLK EN+LLD MN KIADFG SN + G L T CGSP YAAPE+ G Sbjct: 139 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 198 Query: 231 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 290 + Y GPEVD+WS GVILY L+ G+LPFD ++ L +++ G + P Y++ +LLK Sbjct: 199 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKH 258 Query: 291 LLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEP-DPDFNDTKRID-----IMVTMGF 344 +L ++P+KR +++ I + W +++L Y P DP ++ T D + Sbjct: 259 MLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFEC 313 Query: 345 ARDEINDALINQKYDEVMAT--YILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQ 402 + +E+ L N+ + + +A ++++ + E + + S P S L++ L Sbjct: 314 SEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLA-----TSPPDSFLDDHHLT 368 Query: 403 SPAHLKVQRSISANQKQRRFSDHAGP 428 P +V ++ + R D P Sbjct: 369 RPHPERVPFLVAETPRARHTLDELNP 394 >gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 2 [Homo sapiens] Length = 574 Score = 256 bits (653), Expect = 8e-68 Identities = 146/401 (36%), Positives = 229/401 (57%), Gaps = 34/401 (8%) Query: 52 DEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRI 110 D + IG+Y L T+G G F KVK+ +H LTG +VAVKI+++ ++ + K+ RE++ Sbjct: 19 DGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQN 78 Query: 111 MKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------------MK 155 +K+ HP+I+KL++VI T +++VMEY SGGE+FDY+ +GR + Sbjct: 79 LKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELD 138 Query: 156 EKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDT 215 EKE+R F+QI+S V YCH+ +VHRDLK EN+LLD MN KIADFG SN + G L T Sbjct: 139 EKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT 198 Query: 216 FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR 275 CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L +++ G + Sbjct: 199 SCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFY 258 Query: 276 IPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEP-DPDFNDTK 334 P Y++ +LLK +L ++P+KR +++ I + W +++L Y P DP ++ T Sbjct: 259 TPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDPSYSSTM 313 Query: 335 RID-----IMVTMGFARDEINDALINQKYDEVMAT--YILLGRKPPEFEGGESLSSGNLC 387 D + + +E+ L N+ + + +A ++++ + E + + Sbjct: 314 IDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLA---- 369 Query: 388 QRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGP 428 S P S L++ L P +V ++ + R D P Sbjct: 370 -TSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP 409 >gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] Length = 436 Score = 255 bits (651), Expect = 1e-67 Identities = 129/298 (43%), Positives = 193/298 (64%), Gaps = 8/298 (2%) Query: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNH 116 IG YR++ IG GNF++VKL H LT +VA+KI+DKT+L+ + + L RE+ M+ L+H Sbjct: 71 IGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHH 130 Query: 117 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 176 PNI++L+EV+ET L+LVMEYA GGE+F + G++ E E++ F QIVSAV++ H+ Sbjct: 131 PNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHEN 190 Query: 177 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGP 236 I+HRDLKAEN+ + +K+ DFGFS G L+TFCGSPPYAAPELF+ + Y G Sbjct: 191 QIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGI 250 Query: 237 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 296 VD+W+LGV+LY +V+G++PF + + +L++ +L G Y +P ++S C L++ +L P Sbjct: 251 YVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIP 310 Query: 297 IKRGSLEQIMKDRWMNVGHEEEELKPYTEP-DPDFNDTKRIDIMVTMGFARDEINDAL 353 +R ++ IM D WM + PY P +P D K + T+ +E+ L Sbjct: 311 TERYGIDCIMNDEWM-------QGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTL 361 >gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] Length = 661 Score = 252 bits (644), Expect = 8e-67 Identities = 125/258 (48%), Positives = 176/258 (68%), Gaps = 2/258 (0%) Query: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 118 Y LQ+T+GKG + KVK A +GR VA+K I K ++ + + + RE+ IM LNHP+ Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114 Query: 119 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 178 I+ ++EV E + + ++MEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ + Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174 Query: 179 VHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV 238 VHRDLK EN+LLD + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEV Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234 Query: 239 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIK 298 D W+LGV+LYTLV G++PFDG + K L ++ G+YR P S D L++ +L++NP + Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293 Query: 299 RGSLEQIMKDRWMNVGHE 316 R ++E I W+N G++ Sbjct: 294 RATIEDIANHWWVNWGYK 311 >gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] Length = 628 Score = 249 bits (637), Expect = 5e-66 Identities = 129/257 (50%), Positives = 173/257 (67%), Gaps = 3/257 (1%) Query: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 118 Y +T+GKG + KVK AR +GR VA+K I K ++ + L + RE+ IM LNHP+ Sbjct: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Query: 119 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 178 I+ + EV E + +VMEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ + Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 Query: 179 VHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV 238 VHRDLK EN+LLD + NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 Query: 239 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIK 298 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ LL++NP + Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 Query: 299 RGSLEQIMKDRWMNVGH 315 R +LE + W+N G+ Sbjct: 291 RATLEDVASHWWVNWGY 307 >gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] Length = 651 Score = 244 bits (624), Expect = 2e-64 Identities = 135/316 (42%), Positives = 193/316 (61%), Gaps = 13/316 (4%) Query: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119 Y L +TIG G FAKVKLA H+LTG VA+KI+DK L + L ++ E+ +K L H +I Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69 Query: 120 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 179 +L+ V+ET +++V+EY GGE+FDY+++ R+ E+E R FRQIVSAV Y H + Sbjct: 70 CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129 Query: 180 HRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK---LDTFCGSPPYAAPELFQGKKYDGP 236 HRDLK ENLL D +K+ DFG + GNK L T CGS YAAPEL QGK Y G Sbjct: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188 Query: 237 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 296 E DVWS+G++LY L+ G LPFD N+ L ++++RGKY +P ++S LL+++L ++P Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248 Query: 297 IKRGSLEQIMKDRWM----NVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDA 352 KR S++ ++ W+ N E + P+ D D ++ V R + D Sbjct: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDC----VTELSVHHRNNRQTMEDL 304 Query: 353 LINQKYDEVMATYILL 368 + +YD + ATY+LL Sbjct: 305 ISLWQYDHLTATYLLL 320 Score = 52.4 bits (124), Expect = 2e-06 Identities = 30/110 (27%), Positives = 59/110 (53%), Gaps = 2/110 (1%) Query: 687 RDKEEGKDSK-PRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHG 745 R K +G PR L+ +++ TT ++P+ ++ EI +L + D+ QK L Sbjct: 543 RSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQS 602 Query: 746 DARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 795 D + ++ Q+E+EVC+L + + G+R +R+ G + +K + I + K+ Sbjct: 603 DFGKVTM-QFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651 >gi|7657214 hormonally upregulated Neu-associated kinase [Homo sapiens] Length = 714 Score = 233 bits (595), Expect = 4e-61 Identities = 131/355 (36%), Positives = 217/355 (61%), Gaps = 16/355 (4%) Query: 52 DEQPH--IGNYRL-QKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL--QKLFR 106 D Q H +GNY + + +G+G+FAKV+ HVLTG +VA+K+IDK + + + L R Sbjct: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110 Query: 107 EVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 166 E +I +++ HPNI +L +++ETE + YLVME GG + + R++E EAR RQ+ Sbjct: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170 Query: 167 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTF---CGSPPYA 223 +SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + D F CGSP YA Sbjct: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230 Query: 224 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 280 APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P + Sbjct: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289 Query: 281 STDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPD----PDFNDTKRI 336 ST + L+ LL +P+KR +++Q + +RW+N + + T P+ D + + + Sbjct: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349 Query: 337 DIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSR 391 + +G+ ++ + +++ + ++A Y LL +K + G+S +LC ++R Sbjct: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR 404 >gi|16418343 testis-specific serine kinase 3 [Homo sapiens] Length = 268 Score = 195 bits (495), Expect = 2e-49 Identities = 106/257 (41%), Positives = 166/257 (64%), Gaps = 6/257 (2%) Query: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 118 Y+L KTIG+G ++KVK A R+VA+K+IDK +Q+ RE++I++ L+H N Sbjct: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69 Query: 119 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY 177 I++++E++E+ + + LVME A GG+VFD ++ G + E A+A FRQ+V A++YCH Sbjct: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129 Query: 178 IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK--LDTFCGSPPYAAPELFQGKKYDG 235 + HRDLK EN LL G N+K+ DFGF+ ++ TFCGS YAAPE+ QG +D Sbjct: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188 Query: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKLLVL 294 + DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLK+LL Sbjct: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248 Query: 295 NPIKRGSLEQIMKDRWM 311 + I R S+E++ W+ Sbjct: 249 DMILRPSIEEVSWHPWL 265 >gi|14042947 testis-specific serine kinase 1 [Homo sapiens] Length = 367 Score = 191 bits (484), Expect = 3e-48 Identities = 104/263 (39%), Positives = 161/263 (61%), Gaps = 13/263 (4%) Query: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 118 Y L +G+G++AKVK A VA+KIID+ + L+K RE+ I+ +LNH + Sbjct: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71 Query: 119 IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY 177 I+K +E+ ET +Y+VME A G++ + + G + E EAR KF Q+ A++YCH Sbjct: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131 Query: 178 IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-----LDTFCGSPPYAAPELFQGKK 232 +VHRDLK +NLLLD D NIK++DF FS + TFCGSP YAAPE+ QG Sbjct: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191 Query: 233 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 288 Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+ Sbjct: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249 Query: 289 KKLLVLNPIKRGSLEQIMKDRWM 311 +L + +R +++I+ WM Sbjct: 250 YHMLQPDVNRRLHIDEILSHCWM 272 >gi|194294513 testis-specific serine kinase 2 [Homo sapiens] Length = 358 Score = 182 bits (463), Expect = 8e-46 Identities = 101/258 (39%), Positives = 159/258 (61%), Gaps = 15/258 (5%) Query: 66 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLF 123 +GKG++AKVK A VAVKIID+ + PT + F RE+ I+ +NH +I+K + Sbjct: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKK-TPTDFVERFLPREMDILATVNHGSIIKTY 76 Query: 124 EVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRD 182 E+ ET + +Y++ME G++ +++ G + E AR FRQ+ SAV+YCH IVHRD Sbjct: 77 EIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRD 136 Query: 183 LKAENLLLDGDMNIKIADFGFSNEFTVGNK-----LDTFCGSPPYAAPELFQGKKYDGPE 237 LK ENLLLD D NIK++DFGFS + TFCGS YAAPE+ Q Y Sbjct: 137 LKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKV 196 Query: 238 VDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKLLV 293 D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ ++L Sbjct: 197 YDIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQ 254 Query: 294 LNPIKRGSLEQIMKDRWM 311 + +R +++I+ W+ Sbjct: 255 PDVSQRLHIDEILSHSWL 272 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.130 0.371 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 30,985,041 Number of Sequences: 37866 Number of extensions: 1443788 Number of successful extensions: 7465 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 733 Number of HSP's successfully gapped in prelim test: 229 Number of HSP's that attempted gapping in prelim test: 4348 Number of HSP's gapped (non-prelim): 1543 length of query: 795 length of database: 18,247,518 effective HSP length: 110 effective length of query: 685 effective length of database: 14,082,258 effective search space: 9646346730 effective search space used: 9646346730 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.