Search of human proteins with 153266778

Search of human proteins with 153266778

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
         (1167 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]            2360   0.0  
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]            2302   0.0  
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]              2284   0.0  
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]            1372   0.0  
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...  1080   0.0  
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...  1080   0.0  
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             983   0.0  
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      371   e-102
gi|4503787 fyn-related kinase [Homo sapiens]                          370   e-102
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       369   e-101
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              368   e-101
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   363   e-100
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   363   e-100
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   363   e-100
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   359   7e-99
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   359   7e-99
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   358   1e-98
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   358   1e-98
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     355   2e-97
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   348   2e-95
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   347   4e-95
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 344   2e-94
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               332   1e-90
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   331   3e-90
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       322   1e-87
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     316   7e-86
gi|4758078 c-src tyrosine kinase [Homo sapiens]                       316   7e-86
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   305   2e-82
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                305   2e-82
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]      295   2e-79

>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 2360 bits (6115), Expect = 0.0
 Identities = 1167/1167 (100%), Positives = 1167/1167 (100%)

Query: 1    MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEA 60
            MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEA
Sbjct: 1    MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEA 60

Query: 61   LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 120
            LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR
Sbjct: 61   LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 120

Query: 121  VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 180
            VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF
Sbjct: 121  VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 180

Query: 181  LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 240
            LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL
Sbjct: 181  LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 240

Query: 241  VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA 300
            VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA
Sbjct: 241  VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA 300

Query: 301  VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE 360
            VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE
Sbjct: 301  VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE 360

Query: 361  CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT 420
            CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT
Sbjct: 361  CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT 420

Query: 421  GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 480
            GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
Sbjct: 421  GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 480

Query: 481  DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE 540
            DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE
Sbjct: 481  DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE 540

Query: 541  LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ 600
            LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ
Sbjct: 541  LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ 600

Query: 601  ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM 660
            ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM
Sbjct: 601  ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM 660

Query: 661  ENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGG 720
            ENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGG
Sbjct: 661  ENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGG 720

Query: 721  GGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD 780
            GGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD
Sbjct: 721  GGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD 780

Query: 781  RMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPR 840
            RMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPR
Sbjct: 781  RMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPR 840

Query: 841  GATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPS 900
            GATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPS
Sbjct: 841  GATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPS 900

Query: 901  PAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRP 960
            PAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRP
Sbjct: 901  PAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRP 960

Query: 961  RRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGK 1020
            RRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGK
Sbjct: 961  RRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGK 1020

Query: 1021 AGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADL 1080
            AGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADL
Sbjct: 1021 AGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADL 1080

Query: 1081 LSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSA 1140
            LSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSA
Sbjct: 1081 LSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSA 1140

Query: 1141 AAGVPGTNPVLNNLLSCVQEISDVVQR 1167
            AAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1141 AAGVPGTNPVLNNLLSCVQEISDVVQR 1167


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score = 2302 bits (5965), Expect = 0.0
 Identities = 1146/1167 (98%), Positives = 1146/1167 (98%), Gaps = 21/1167 (1%)

Query: 1    MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEA 60
            MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLT                     EA
Sbjct: 1    MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLT---------------------EA 39

Query: 61   LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 120
            LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR
Sbjct: 40   LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 99

Query: 121  VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 180
            VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF
Sbjct: 100  VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 159

Query: 181  LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 240
            LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL
Sbjct: 160  LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 219

Query: 241  VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA 300
            VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA
Sbjct: 220  VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA 279

Query: 301  VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE 360
            VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE
Sbjct: 280  VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE 339

Query: 361  CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT 420
            CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT
Sbjct: 340  CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT 399

Query: 421  GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 480
            GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
Sbjct: 400  GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 459

Query: 481  DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE 540
            DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE
Sbjct: 460  DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE 519

Query: 541  LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ 600
            LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ
Sbjct: 520  LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ 579

Query: 601  ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM 660
            ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM
Sbjct: 580  ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM 639

Query: 661  ENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGG 720
            ENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGG
Sbjct: 640  ENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGG 699

Query: 721  GGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD 780
            GGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD
Sbjct: 700  GGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD 759

Query: 781  RMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPR 840
            RMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPR
Sbjct: 760  RMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPR 819

Query: 841  GATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPS 900
            GATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPS
Sbjct: 820  GATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPS 879

Query: 901  PAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRP 960
            PAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRP
Sbjct: 880  PAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRP 939

Query: 961  RRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGK 1020
            RRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGK
Sbjct: 940  RRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGK 999

Query: 1021 AGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADL 1080
            AGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADL
Sbjct: 1000 AGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADL 1059

Query: 1081 LSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSA 1140
            LSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSA
Sbjct: 1060 LSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSA 1119

Query: 1141 AAGVPGTNPVLNNLLSCVQEISDVVQR 1167
            AAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1120 AAGVPGTNPVLNNLLSCVQEISDVVQR 1146


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 2284 bits (5919), Expect = 0.0
 Identities = 1130/1130 (100%), Positives = 1130/1130 (100%)

Query: 38   DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF 97
            DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF
Sbjct: 53   DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF 112

Query: 98   VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157
            VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS
Sbjct: 113  VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 172

Query: 158  WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 217
            WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV
Sbjct: 173  WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 232

Query: 218  TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH 277
            TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH
Sbjct: 233  TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH 292

Query: 278  KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337
            KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT
Sbjct: 293  KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 352

Query: 338  LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397
            LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA
Sbjct: 353  LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 412

Query: 398  RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 457
            RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG
Sbjct: 413  RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 472

Query: 458  VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517
            VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF
Sbjct: 473  VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532

Query: 518  AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI 577
            AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI
Sbjct: 533  AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI 592

Query: 578  EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF 637
            EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF
Sbjct: 593  EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF 652

Query: 638  FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANL 697
            FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANL
Sbjct: 653  FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANL 712

Query: 698  VPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASD 757
            VPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASD
Sbjct: 713  VPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASD 772

Query: 758  DTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDM 817
            DTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDM
Sbjct: 773  DTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDM 832

Query: 818  LPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKE 877
            LPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKE
Sbjct: 833  LPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKE 892

Query: 878  KNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTD 937
            KNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTD
Sbjct: 893  KNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTD 952

Query: 938  SQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAG 997
            SQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAG
Sbjct: 953  SQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAG 1012

Query: 998  QSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKT 1057
            QSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKT
Sbjct: 1013 QSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKT 1072

Query: 1058 KQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRN 1117
            KQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRN
Sbjct: 1073 KQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRN 1132

Query: 1118 KFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1167
            KFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1133 KFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score = 1372 bits (3551), Expect = 0.0
 Identities = 672/672 (100%), Positives = 672/672 (100%)

Query: 1   MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEA 60
           MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEA
Sbjct: 1   MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEA 60

Query: 61  LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 120
           LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR
Sbjct: 61  LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 120

Query: 121 VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 180
           VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF
Sbjct: 121 VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 180

Query: 181 LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 240
           LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL
Sbjct: 181 LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 240

Query: 241 VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA 300
           VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA
Sbjct: 241 VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA 300

Query: 301 VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE 360
           VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE
Sbjct: 301 VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE 360

Query: 361 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT 420
           CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT
Sbjct: 361 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT 420

Query: 421 GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 480
           GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
Sbjct: 421 GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 480

Query: 481 DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE 540
           DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE
Sbjct: 481 DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE 540

Query: 541 LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ 600
           LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ
Sbjct: 541 LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ 600

Query: 601 ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM 660
           ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM
Sbjct: 601 ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM 660

Query: 661 ENQPHKKYELTG 672
           ENQPHKKYELTG
Sbjct: 661 ENQPHKKYELTG 672



 Score =  783 bits (2021), Expect = 0.0
 Identities = 393/394 (99%), Positives = 394/394 (100%)

Query: 774  SGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP 833
            +GLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP
Sbjct: 671  TGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP 730

Query: 834  KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG 893
            KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG
Sbjct: 731  KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG 790

Query: 894  EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS 953
            EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS
Sbjct: 791  EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS 850

Query: 954  SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG 1013
            SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG
Sbjct: 851  SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG 910

Query: 1014 AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA 1073
            AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA
Sbjct: 911  AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA 970

Query: 1074 LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ 1133
            LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ
Sbjct: 971  LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ 1030

Query: 1134 ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1167
            ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1031 ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1064


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
            [Homo sapiens]
          Length = 1130

 Score = 1080 bits (2794), Expect = 0.0
 Identities = 631/1165 (54%), Positives = 755/1165 (64%), Gaps = 117/1165 (10%)

Query: 59   EALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGE 117
            EAL RP   D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGE
Sbjct: 27   EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 86

Query: 118  KLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN 177
            KLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS IN
Sbjct: 87   KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 146

Query: 178  GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA 237
            GSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVA
Sbjct: 147  GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 206

Query: 238  DGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSL 297
            DGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSL
Sbjct: 207  DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266

Query: 298  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 357
            TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDY
Sbjct: 267  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326

Query: 358  LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 417
            LRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSR
Sbjct: 327  LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 386

Query: 418  LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 477
            LMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 387  LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 446

Query: 478  QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 537
            QVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS+EV
Sbjct: 447  QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV 506

Query: 538  AEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIR 597
             +ELG+     +V   L + P LP+KTRT ++  E+++  +  +           P    
Sbjct: 507  EKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDP---- 561

Query: 598  GAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM--KKRNAPTPPKRSS 655
                 + SP LPRK+R      L ED  E    +D+K   FS+ +  KK+ APTPPKRSS
Sbjct: 562  LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIKKKKKTAPTPPKRSS 619

Query: 656  SFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLC 713
            SFREM+ QP ++   E  G   S  +L      +FTP         PK   G+       
Sbjct: 620  SFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKSPKPSNGAGVPNGAL 673

Query: 714  NDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPTASDDTSKPFPRSNS 768
             + GG               +GF +P L KK+  L +     G+      +SK F RS S
Sbjct: 674  RESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCS 718

Query: 769  TSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAP 828
             S +  G  + +  ++TLPR+ Q +  Q + +                    KSE+ A P
Sbjct: 719  ASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG---------------HKSEKPALP 763

Query: 829  SRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVGVAGVAAAPKGKEKN 879
             +     ++  + RG    P R     + A  E      +  PG     +   P  ++  
Sbjct: 764  RKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVT 823

Query: 880  GGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQ 939
                 G+    E G+     +PA A PV PT+   K            PA+      +S+
Sbjct: 824  VAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTSKGPAE------ESR 874

Query: 940  GNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQS 999
              + K  SE   +   DK +  R+KP  APPPPP             P++ P+   AG++
Sbjct: 875  VRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGGKPSQSPSQEAAGEA 926

Query: 1000 T---------------------SETQEGGKKAALGAVPISGKA---GRPVMPPPQVP--L 1033
                                  S+  EG KK  L A P    A   G P+ P P VP  L
Sbjct: 927  VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAP-VPSTL 985

Query: 1034 PTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEALLECADLLSSALT- 1086
            P++S + A    + TA      T+V+LRKT+Q  E+I++  I+K  +L+  + L  A++ 
Sbjct: 986  PSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISR 1045

Query: 1087 ---EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAG 1143
               +   +S +++ G  L  +C  YVD I Q RNKFAFREA++KLE +L+ELQ+  A AG
Sbjct: 1046 NSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAG 1105

Query: 1144 V-PGTNPVLNNLLSCVQEISDVVQR 1167
              P      + LLS V+EISD+VQR
Sbjct: 1106 SGPAATQDFSKLLSSVKEISDIVQR 1130


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
            [Homo sapiens]
          Length = 1149

 Score = 1080 bits (2794), Expect = 0.0
 Identities = 631/1165 (54%), Positives = 755/1165 (64%), Gaps = 117/1165 (10%)

Query: 59   EALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGE 117
            EAL RP   D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGE
Sbjct: 46   EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 105

Query: 118  KLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN 177
            KLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS IN
Sbjct: 106  KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 165

Query: 178  GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA 237
            GSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVA
Sbjct: 166  GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 225

Query: 238  DGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSL 297
            DGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSL
Sbjct: 226  DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 285

Query: 298  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 357
            TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDY
Sbjct: 286  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 345

Query: 358  LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 417
            LRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSR
Sbjct: 346  LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 405

Query: 418  LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 477
            LMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 406  LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 465

Query: 478  QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 537
            QVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS+EV
Sbjct: 466  QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV 525

Query: 538  AEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIR 597
             +ELG+     +V   L + P LP+KTRT ++  E+++  +  +           P    
Sbjct: 526  EKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDP---- 580

Query: 598  GAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM--KKRNAPTPPKRSS 655
                 + SP LPRK+R      L ED  E    +D+K   FS+ +  KK+ APTPPKRSS
Sbjct: 581  LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIKKKKKTAPTPPKRSS 638

Query: 656  SFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLC 713
            SFREM+ QP ++   E  G   S  +L      +FTP         PK   G+       
Sbjct: 639  SFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKSPKPSNGAGVPNGAL 692

Query: 714  NDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPTASDDTSKPFPRSNS 768
             + GG               +GF +P L KK+  L +     G+      +SK F RS S
Sbjct: 693  RESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCS 737

Query: 769  TSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAP 828
             S +  G  + +  ++TLPR+ Q +  Q + +                    KSE+ A P
Sbjct: 738  ASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG---------------HKSEKPALP 782

Query: 829  SRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVGVAGVAAAPKGKEKN 879
             +     ++  + RG    P R     + A  E      +  PG     +   P  ++  
Sbjct: 783  RKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVT 842

Query: 880  GGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQ 939
                 G+    E G+     +PA A PV PT+   K            PA+      +S+
Sbjct: 843  VAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTSKGPAE------ESR 893

Query: 940  GNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQS 999
              + K  SE   +   DK +  R+KP  APPPPP             P++ P+   AG++
Sbjct: 894  VRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGGKPSQSPSQEAAGEA 945

Query: 1000 T---------------------SETQEGGKKAALGAVPISGKA---GRPVMPPPQVP--L 1033
                                  S+  EG KK  L A P    A   G P+ P P VP  L
Sbjct: 946  VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAP-VPSTL 1004

Query: 1034 PTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEALLECADLLSSALT- 1086
            P++S + A    + TA      T+V+LRKT+Q  E+I++  I+K  +L+  + L  A++ 
Sbjct: 1005 PSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISR 1064

Query: 1087 ---EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAG 1143
               +   +S +++ G  L  +C  YVD I Q RNKFAFREA++KLE +L+ELQ+  A AG
Sbjct: 1065 NSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAG 1124

Query: 1144 V-PGTNPVLNNLLSCVQEISDVVQR 1167
              P      + LLS V+EISD+VQR
Sbjct: 1125 SGPAATQDFSKLLSSVKEISDIVQR 1149


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  983 bits (2542), Expect = 0.0
 Identities = 477/477 (100%), Positives = 477/477 (100%)

Query: 59  EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 118
           EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK
Sbjct: 53  EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 112

Query: 119 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 178
           LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING
Sbjct: 113 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 172

Query: 179 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 238
           SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD
Sbjct: 173 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 232

Query: 239 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 298
           GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT
Sbjct: 233 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 292

Query: 299 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 358
           VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL
Sbjct: 293 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 352

Query: 359 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 418
           RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL
Sbjct: 353 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 412

Query: 419 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 478
           MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ
Sbjct: 413 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 472

Query: 479 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 535
           VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE
Sbjct: 473 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 529


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  371 bits (952), Expect = e-102
 Identities = 201/455 (44%), Positives = 281/455 (61%), Gaps = 15/455 (3%)

Query: 96  LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
           LFVALYD+ A  ++ LS  KGEK ++L  ++ G+W E RS      G++PSNY+ PV+S+
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 206
           +   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R         V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204

Query: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 266
           I    +G  Y+T  ++F TL +LV H+S  ADGL   L   A  C  P   G++   D W
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261

Query: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
           E+ R  + ++ KLG G + EV++G W   +  VA+KTLK  TM  E FL+EA +MK++KH
Sbjct: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320

Query: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
             LVQL  V + E P YIVTEYM  G+LLD+L++     +    L+ MA Q+++ M Y+E
Sbjct: 321 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379

Query: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
           + N+IHRDL + N LVG   + K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  
Sbjct: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439

Query: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
           F+IKSDVW+FG+LL E+ T G  PYPG++  +V + +E+GYRM  P+ CP  ++ELM  C
Sbjct: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499

Query: 507 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
           WK  P +RP+F       E  F  +    +  E L
Sbjct: 500 WKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  370 bits (949), Expect = e-102
 Identities = 198/454 (43%), Positives = 273/454 (60%), Gaps = 16/454 (3%)

Query: 97  FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW--------SEVRSKNGQGWVPSNYIT 148
           FVAL+D+ A     LS   G+KL+VL     G W         +  S+  QG++PSNY+ 
Sbjct: 47  FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106

Query: 149 PVNSLEKHSWYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 206
              SL+   W+ G + RS AE   L S    GSFL+RESES  G+ S+S+     V HYR
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166

Query: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 265
           I    +G  ++T    FSTL E V H++  +DGL   L  P  K   P  + +S    D+
Sbjct: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226

Query: 266 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 325
           WE++R  I +  +LG GQ+GEV+ G+W   +  VAVKTLK  +M+  +FL+EA +MK ++
Sbjct: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285

Query: 326 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 385
           HP L+QL  VCTLE P YI+TE M +G+L +YL+     ++     + MA Q++S M YL
Sbjct: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345

Query: 386 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESL 442
           E +N+IHRDLAARN LVGE+++ KVADFGL+R+      D Y +    K P+KWTAPE++
Sbjct: 346 ESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI 405

Query: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 502
             N FSIKSDVW+FG+LL+EI TYG  PY G+  +QV  +L + YR+ QP  CP + Y +
Sbjct: 406 RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465

Query: 503 MRACWKWSPADRPSFAETHQAFETMFH-DSSISE 535
           M  CW   P +RP+F       E  F  DSS S+
Sbjct: 466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  369 bits (946), Expect = e-101
 Identities = 201/456 (44%), Positives = 281/456 (61%), Gaps = 14/456 (3%)

Query: 96  LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
           LFVALYD+ A  ++ LS  KGEK ++L  ++ G+W E RS      G++PSNY+ PV+S+
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 206
           +   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R         V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204

Query: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 265
           I    +G  Y+T  ++F TL +LV H+S  A GL   L  P  K   P +  +S    D 
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263

Query: 266 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 325
           WE+ R  + +  +LG GQ+GEV++G W   +  VA+KTLK  TM  E FL+EA +MK++K
Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322

Query: 326 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 385
           H  LVQL  V + E P YIVTEYM  G+LLD+L++     +    L+ MA Q+++ M Y+
Sbjct: 323 HDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381

Query: 386 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 445
           E+ N+IHRDL + N LVG   + K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y 
Sbjct: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441

Query: 446 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 505
            F+IKSDVW+FG+LL E+ T G  PYPG++  +V + +E+GYRM  P+ CP  ++ELM  
Sbjct: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501

Query: 506 CWKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
           CWK  P +RP+F       E  F  +    +  E L
Sbjct: 502 CWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  368 bits (944), Expect = e-101
 Identities = 202/455 (44%), Positives = 279/455 (61%), Gaps = 15/455 (3%)

Query: 96  LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
           +FVALYD+ A     LS  KGE+ +++  N  G+W E RS      G++PSNY+ P +S+
Sbjct: 95  IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153

Query: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 206
           +   WY G + R  AE LL +  N  G FLVRESE++ G  S+S+R         V HY+
Sbjct: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213

Query: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 266
           I    +G  Y+T  ++F TL +LV H++  ADGL   L    P   KP   G++   D W
Sbjct: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270

Query: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
           E+ R  + ++ KLG G +GEV++G W   +  VA+KTLK  TM  E FL+EA +MK+++H
Sbjct: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329

Query: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
             LV L  V + E P YIVTE+M  G+LLD+L+E + + +    L+ MA QI+  M Y+E
Sbjct: 330 DKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388

Query: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
           + N+IHRDL A N LVGEN V K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  
Sbjct: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448

Query: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
           F+IKSDVW+FG+L  E+ T G  PYPG+   +V + +E+GYRM  P+GCP  ++ELM  C
Sbjct: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508

Query: 507 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
           WK  P +RP+F       E  F  +    +  E L
Sbjct: 509 WKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL 543


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  363 bits (933), Expect = e-100
 Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%)

Query: 62  HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 121
           H P   +   QA+N     S    + G +     LF+ALYD+ A  ++ L+ TKGEK  +
Sbjct: 49  HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106

Query: 122 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 177
           L  N  G+W E RS +    G +PSNY+ PV+S++   WY G + R  AE  L S  N  
Sbjct: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165

Query: 178 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 232
           G+FL+RESE++ G  S+S+R         V HY+I     G  Y+T   +F+++ ELV H
Sbjct: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225

Query: 233 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 292
           +  V DGL   L  P     KP   G++   D WE+ R+ IT++ +LG G +G+V++G W
Sbjct: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282

Query: 293 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 352
              S  VAVKTLK  TM  + FL+EA VMK ++H  LVQL  V + E P YIVTE+M +G
Sbjct: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340

Query: 353 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 412
           +LLD+L+    +++    L+ MA Q++  M Y+E+ N+IHRDL A N LVGE    K+AD
Sbjct: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400

Query: 413 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 472
           FGL+RL+  D Y    G+KFPIKWTAPE+  +  F+IKSDVW+FG+LL E+ T G  PYP
Sbjct: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460

Query: 473 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 528
           G++  +V + +E+GY M  P GCP  +YE M   W+  P +RP+F       E  F
Sbjct: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  363 bits (933), Expect = e-100
 Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%)

Query: 62  HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 121
           H P   +   QA+N     S    + G +     LF+ALYD+ A  ++ L+ TKGEK  +
Sbjct: 49  HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106

Query: 122 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 177
           L  N  G+W E RS +    G +PSNY+ PV+S++   WY G + R  AE  L S  N  
Sbjct: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165

Query: 178 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 232
           G+FL+RESE++ G  S+S+R         V HY+I     G  Y+T   +F+++ ELV H
Sbjct: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225

Query: 233 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 292
           +  V DGL   L  P     KP   G++   D WE+ R+ IT++ +LG G +G+V++G W
Sbjct: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282

Query: 293 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 352
              S  VAVKTLK  TM  + FL+EA VMK ++H  LVQL  V + E P YIVTE+M +G
Sbjct: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340

Query: 353 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 412
           +LLD+L+    +++    L+ MA Q++  M Y+E+ N+IHRDL A N LVGE    K+AD
Sbjct: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400

Query: 413 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 472
           FGL+RL+  D Y    G+KFPIKWTAPE+  +  F+IKSDVW+FG+LL E+ T G  PYP
Sbjct: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460

Query: 473 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 528
           G++  +V + +E+GY M  P GCP  +YE M   W+  P +RP+F       E  F
Sbjct: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  363 bits (933), Expect = e-100
 Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%)

Query: 62  HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 121
           H P   +   QA+N     S    + G +     LF+ALYD+ A  ++ L+ TKGEK  +
Sbjct: 49  HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106

Query: 122 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 177
           L  N  G+W E RS +    G +PSNY+ PV+S++   WY G + R  AE  L S  N  
Sbjct: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165

Query: 178 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 232
           G+FL+RESE++ G  S+S+R         V HY+I     G  Y+T   +F+++ ELV H
Sbjct: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225

Query: 233 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 292
           +  V DGL   L  P     KP   G++   D WE+ R+ IT++ +LG G +G+V++G W
Sbjct: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282

Query: 293 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 352
              S  VAVKTLK  TM  + FL+EA VMK ++H  LVQL  V + E P YIVTE+M +G
Sbjct: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340

Query: 353 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 412
           +LLD+L+    +++    L+ MA Q++  M Y+E+ N+IHRDL A N LVGE    K+AD
Sbjct: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400

Query: 413 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 472
           FGL+RL+  D Y    G+KFPIKWTAPE+  +  F+IKSDVW+FG+LL E+ T G  PYP
Sbjct: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460

Query: 473 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 528
           G++  +V + +E+GY M  P GCP  +YE M   W+  P +RP+F       E  F
Sbjct: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  359 bits (922), Expect = 7e-99
 Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)

Query: 97  FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 155
           FVALYD+ +  +  LS  KGE+L+++   +   W       GQ G++PSNY+ P +S++ 
Sbjct: 89  FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148

Query: 156 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 208
             WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +G  V HY+I 
Sbjct: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208

Query: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 268
               G  Y+T+ ++F++L +LV ++S  ADGL   L    P  +KP   G++   D WE+
Sbjct: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265

Query: 269 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 328
            R  + ++ KLG G +GEV++G W   +  VA+KTLK  TM  E FL+EA VMK+++H  
Sbjct: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324

Query: 329 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388
           LVQL  V + E P YIVTEYM  G+LLD+L+    + +    L+ MA QI+S M Y+E+ 
Sbjct: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383

Query: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448
           N++HRDL A N LVGEN V KVADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  F+
Sbjct: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443

Query: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508
           IKSDVW+FG+LL E+ T G  PYPG+   +V D +E+GYRM  P  CP  +++LM  CW+
Sbjct: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503

Query: 509 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
             P +RP+F       E  F  +    +  E L
Sbjct: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  359 bits (922), Expect = 7e-99
 Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)

Query: 97  FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 155
           FVALYD+ +  +  LS  KGE+L+++   +   W       GQ G++PSNY+ P +S++ 
Sbjct: 89  FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148

Query: 156 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 208
             WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +G  V HY+I 
Sbjct: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208

Query: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 268
               G  Y+T+ ++F++L +LV ++S  ADGL   L    P  +KP   G++   D WE+
Sbjct: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265

Query: 269 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 328
            R  + ++ KLG G +GEV++G W   +  VA+KTLK  TM  E FL+EA VMK+++H  
Sbjct: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324

Query: 329 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388
           LVQL  V + E P YIVTEYM  G+LLD+L+    + +    L+ MA QI+S M Y+E+ 
Sbjct: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383

Query: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448
           N++HRDL A N LVGEN V KVADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  F+
Sbjct: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443

Query: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508
           IKSDVW+FG+LL E+ T G  PYPG+   +V D +E+GYRM  P  CP  +++LM  CW+
Sbjct: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503

Query: 509 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
             P +RP+F       E  F  +    +  E L
Sbjct: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  358 bits (920), Expect = 1e-98
 Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)

Query: 89  ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 146
           A+    NL +AL+ +  S D  L   KGE+LR+L   Q+GEW + +S     +G++P N+
Sbjct: 58  ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115

Query: 147 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 200
           +   NSLE   W+   +SR  AE  L +  N  GSFL+RESES+ G  S+S+R     +G
Sbjct: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175

Query: 201 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 257
            V  HY+I    +G  Y++    F  L ELV H++  +DGL T L  P    K  KP   
Sbjct: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234

Query: 258 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 317
                 D+WE+ R  + +  +LG GQ+GEV++G +  ++  VAVK+LK+ +M  + FL E
Sbjct: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288

Query: 318 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 377
           A +MK+++H  LV+L  V T EP  YI+TEYM  G+L+D+L+  +  ++T   LL MA Q
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347

Query: 378 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 437
           I+  M ++E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWT
Sbjct: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407

Query: 438 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 497
           APE++ Y TF+IKSDVW+FG+LL EI T+G  PYPG+   +V   LE+GYRM +P+ CP 
Sbjct: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467

Query: 498 KVYELMRACWKWSPADRPSFAETHQAFETMF 528
           ++Y+LMR CWK  P DRP+F       E  F
Sbjct: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  358 bits (920), Expect = 1e-98
 Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)

Query: 89  ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 146
           A+    NL +AL+ +  S D  L   KGE+LR+L   Q+GEW + +S     +G++P N+
Sbjct: 58  ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115

Query: 147 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 200
           +   NSLE   W+   +SR  AE  L +  N  GSFL+RESES+ G  S+S+R     +G
Sbjct: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175

Query: 201 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 257
            V  HY+I    +G  Y++    F  L ELV H++  +DGL T L  P    K  KP   
Sbjct: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234

Query: 258 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 317
                 D+WE+ R  + +  +LG GQ+GEV++G +  ++  VAVK+LK+ +M  + FL E
Sbjct: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288

Query: 318 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 377
           A +MK+++H  LV+L  V T EP  YI+TEYM  G+L+D+L+  +  ++T   LL MA Q
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347

Query: 378 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 437
           I+  M ++E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWT
Sbjct: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407

Query: 438 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 497
           APE++ Y TF+IKSDVW+FG+LL EI T+G  PYPG+   +V   LE+GYRM +P+ CP 
Sbjct: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467

Query: 498 KVYELMRACWKWSPADRPSFAETHQAFETMF 528
           ++Y+LMR CWK  P DRP+F       E  F
Sbjct: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  355 bits (910), Expect = 2e-97
 Identities = 199/450 (44%), Positives = 281/450 (62%), Gaps = 23/450 (5%)

Query: 81  SSKENLLGATE--SDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--K 136
           S   N  G  E  S+  + VALYD+ A     LS  KG+++ VL   ++GEW + RS   
Sbjct: 65  SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLAT 122

Query: 137 NGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSI 194
             +G++PSNY+  V+SLE   W+   +SR  AE  L +  N  GSF++R+SE++ G  S+
Sbjct: 123 RKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSL 182

Query: 195 SLR-YEGR----VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP-- 247
           S+R Y+ R    V HY+I T  +G  Y++  S FSTL ELV H+    DGL   L  P  
Sbjct: 183 SVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM 242

Query: 248 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED 307
           + K  KP         D WE+ R  + ++ KLG GQ+GEV++  + K++  VAVKT+K  
Sbjct: 243 SSKPQKPWE------KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPG 295

Query: 308 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 367
           +M VE FL EA VMK ++H  LV+L  V T EP  YI+TE+M  G+LLD+L+     +  
Sbjct: 296 SMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQP 354

Query: 368 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH 427
              L+  + QI+  M ++E++N+IHRDL A N LV  + V K+ADFGL+R++  + YTA 
Sbjct: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414

Query: 428 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY 487
            GAKFPIKWTAPE++ + +F+IKSDVW+FG+LL EI TYG  PYPG+   +V   LE+GY
Sbjct: 415 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 474

Query: 488 RMEQPEGCPPKVYELMRACWKWSPADRPSF 517
           RM +PE CP ++Y +M  CWK  P +RP+F
Sbjct: 475 RMPRPENCPEELYNIMMRCWKNRPEERPTF 504


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  348 bits (893), Expect = 2e-95
 Identities = 190/463 (41%), Positives = 281/463 (60%), Gaps = 20/463 (4%)

Query: 66  GCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN 125
           G D++ Q + E+     +       E   ++ VALY +     + LS  KGEK++VL   
Sbjct: 16  GVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--E 73

Query: 126 QNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFL 181
           ++GEW + +S     +G++PSNY+  +N+LE   W+   ++R  AE  L +  N  G+FL
Sbjct: 74  EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133

Query: 182 VRESESSPGQLSISLRYEGRVY-----HYRINTTADGKVYVTAESRFSTLAELVHHHSTV 236
           +RESE+  G  S+S+R    V+     HY+I +  +G  Y++    F  +++++ H+   
Sbjct: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193

Query: 237 ADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKK 294
           ADGL   L     +PK  KP         D WE+ R  I +  +LG GQ+GEV++G +  
Sbjct: 194 ADGLCRRLEKACISPKPQKPWD------KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN 247

Query: 295 YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 354
            S  VAVKTLK  TM V+ FL+EA +MK ++H  LV+L  V T E P YI+TEYM  G+L
Sbjct: 248 -STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 306

Query: 355 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 414
           LD+L+     +V    L+  + QI+  M Y+E+KN+IHRDL A N LV E+ + K+ADFG
Sbjct: 307 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG 366

Query: 415 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 474
           L+R++  + YTA  GAKFPIKWTAPE++ +  F+IKSDVW+FG+LL+EI TYG  PYPG 
Sbjct: 367 LARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 426

Query: 475 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517
             + V   L +GYRM + E CP ++Y++M+ CWK    +RP+F
Sbjct: 427 TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  347 bits (890), Expect = 4e-95
 Identities = 186/438 (42%), Positives = 272/438 (62%), Gaps = 20/438 (4%)

Query: 91  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 148
           E   ++ VALY +     + LS  KGEK++VL   ++GEW + +S     +G++PSNY+ 
Sbjct: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119

Query: 149 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVY--- 203
            +N+LE   W+   ++R  AE  L +  N  G+FL+RESE+  G  S+S+R    V+   
Sbjct: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179

Query: 204 --HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGV 259
             HY+I +  +G  Y++    F  +++++ H+   ADGL   L     +PK  KP     
Sbjct: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD--- 236

Query: 260 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 319
               D WE+ R  I +  +LG GQ+GEV++G +   S  VAVKTLK  TM V+ FL+EA 
Sbjct: 237 ---KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292

Query: 320 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 379
           +MK ++H  LV+L  V T E P YI+TEYM  G+LLD+L+     +V    L+  + QI+
Sbjct: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352

Query: 380 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 439
             M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAP
Sbjct: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412

Query: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499
           E++ +  F+IKSDVW+FG+LL+EI TYG  PYPG   + V   L +GYRM + E CP ++
Sbjct: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472

Query: 500 YELMRACWKWSPADRPSF 517
           Y++M+ CWK    +RP+F
Sbjct: 473 YDIMKMCWKEKAEERPTF 490


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  344 bits (883), Expect = 2e-94
 Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)

Query: 91  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 148
           + D +  VALYD+ A  D  L + KGEKL+VL     G+W   RS     +G+VPSN++ 
Sbjct: 57  DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114

Query: 149 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 202
            V SLE   W+     R  AE  L + IN  GSFL+RESE++ G  S+S++    +G  +
Sbjct: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174

Query: 203 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 262
            HY+I    +G  Y++    F +L  LV H+S   DGL   L  P   C +P        
Sbjct: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230

Query: 263 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 322
            D+WE+ R  + +  KLG GQ+GEV++G +K  ++ VA+KTLKE TM  E FL EA VMK
Sbjct: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289

Query: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382
            ++H  LV+L  V T EP  YIVTEYM  G LLD+L+      ++   L+ M+ QI+  M
Sbjct: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348

Query: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 442
            Y+E+ N IHRDL A N LV E    K+ADFGL+R++  + YTA  GAKFPIKWTAPE++
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407

Query: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 501
            +  F+IK+DVW+FGVLL E+ TYG  PYPG+   +V   LE+GYRM +P+ CPP++Y  
Sbjct: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467

Query: 502 LMRACWKWSPADRPSFAETHQAFETMF 528
           ++  CW+  P +RP+F       E  +
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  332 bits (851), Expect = 1e-90
 Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)

Query: 91  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 148
           ++   + VA+YDF A+  + L + +G++  +L  N +  W   R K G +G++PSNY+T 
Sbjct: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236

Query: 149 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 200
              N+L+++ WY   ++RS AE LL S    G F+VR+S S PG  ++SL  ++ G    
Sbjct: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295

Query: 201 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 256
             R YH +  TT+  K Y+  +  F ++ E++ +H   A GLVT L YP     K  PT 
Sbjct: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355

Query: 257 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 316
            G S  ++KWE+  +++T   +LG G +G V +G W+     VA+K ++E  M  E+F++
Sbjct: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412

Query: 317 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 376
           EA VM ++ HP LVQL GVCT + P YIVTE+M  G LL++LR+  +   +  VLL M  
Sbjct: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471

Query: 377 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 436
            +   MEYLE+ +FIHRDLAARNCLV E  VVKV+DFG++R +  D YT+ +GAKFP+KW
Sbjct: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531

Query: 437 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 496
             PE   Y+ FS KSDVW+FGVL+WE+ T G  P+      +V  ++ +G+R+ QP+   
Sbjct: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591

Query: 497 PKVYELMRACWKWSPADRPSFAE 519
             VYE+M  CW+  P  RPSF +
Sbjct: 592 NYVYEVMLRCWQEKPEGRPSFED 614


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  331 bits (848), Expect = 3e-90
 Identities = 182/431 (42%), Positives = 261/431 (60%), Gaps = 17/431 (3%)

Query: 98  VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPV-NSLEK 155
           VALYD++    N L + KG++  +L    N  W   R KNGQ G++PSNY+T   +S+E 
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILE-ESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEM 278

Query: 156 HSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRY------EGRVYHYRIN 208
           + WY   ++RS AE LL      G F+VR+S S  G+ ++S+        +G + HY + 
Sbjct: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337

Query: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 266
           +T   + Y+  +  FST+ EL+++H   + GL++ L YP  + NK  P+  G+   +  W
Sbjct: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG--YGSW 395

Query: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
           E++  D+T   +LG GQ+G V  G W+     VA+K +KE +M  +EF++EA VM  + H
Sbjct: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454

Query: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
             LVQL GVCT + P +I+TEYM  G LL+YLRE  R       LL M   +  AMEYLE
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLE 513

Query: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
            K F+HRDLAARNCLV +  VVKV+DFGLSR +  D YT+  G+KFP++W+ PE L Y+ 
Sbjct: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573

Query: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
           FS KSD+WAFGVL+WEI + G  PY     S+  + + +G R+ +P     KVY +M +C
Sbjct: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633

Query: 507 WKWSPADRPSF 517
           W     +RP+F
Sbjct: 634 WHEKADERPTF 644


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  322 bits (825), Expect = 1e-87
 Identities = 173/437 (39%), Positives = 261/437 (59%), Gaps = 18/437 (4%)

Query: 99  ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITP--VNSLEK 155
           ALYDF+      L++ + E+  +L    N  W + R + G +G +PSNY+T   + +LE 
Sbjct: 89  ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147

Query: 156 HSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISL------RYEGRVYHYRIN 208
           + WYH  ++R+ AE+LL      G+F+VR+S    G  +IS+        E  + HY+I 
Sbjct: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206

Query: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 266
               G+ YV     F ++ EL+ +H   A GL+T L YP        P   G S  ++KW
Sbjct: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264

Query: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
           E++ +++    ++G GQ+G V++G W+ + + VA+K + E +M  E+F++EA VM ++ H
Sbjct: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323

Query: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
             LVQL GVC    P YIVTE+M  G LL+YLRE N+ ++   +LL +   I   MEYLE
Sbjct: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382

Query: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
           +  +IHRDLAARNCLV    +VK++DFG++R +  D Y +  GAKFPIKW+ PE   +N 
Sbjct: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442

Query: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
           +S KSDVW+FGVL+WE+ T G  P+      QV + + +G+R+ +P   P  +YE+M +C
Sbjct: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502

Query: 507 WKWSPADRPSFAETHQA 523
           W   P  RP+FAE  +A
Sbjct: 503 WHEKPEGRPTFAELLRA 519


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  316 bits (810), Expect = 7e-86
 Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)

Query: 98  VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 156
           +A Y+F  + +  L   KG+ L ++   ++  W + ++K G +G +P+NY+     ++  
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74

Query: 157 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
           +      W+HG ++R  AE LL     G FLVRES + PG  ++ +  +G+V HYRI   
Sbjct: 75  TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134

Query: 211 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 269
           A  K+ +  E  F  L +LV H+++ ADGL T L    PK  + TV      +   W + 
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191

Query: 270 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 329
             ++ +   +G G++G+V +G ++     VAVK +K D    + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248

Query: 330 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388
           VQLLGV   E    YIVTEYM  G+L+DYLR   R  +    LL  +  +  AMEYLE  
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308

Query: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448
           NF+HRDLAARN LV E++V KV+DFGL++  +    T     K P+KWTAPE+L    FS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364

Query: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508
            KSDVW+FG+LLWEI ++G  PYP I L  V   +EKGY+M+ P+GCPP VYE+M+ CW 
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424

Query: 509 WSPADRPSFAETHQAFE 525
              A RPSF +  +  E
Sbjct: 425 LDAAMRPSFLQLREQLE 441


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  316 bits (810), Expect = 7e-86
 Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)

Query: 98  VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 156
           +A Y+F  + +  L   KG+ L ++   ++  W + ++K G +G +P+NY+     ++  
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74

Query: 157 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
           +      W+HG ++R  AE LL     G FLVRES + PG  ++ +  +G+V HYRI   
Sbjct: 75  TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134

Query: 211 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 269
           A  K+ +  E  F  L +LV H+++ ADGL T L    PK  + TV      +   W + 
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191

Query: 270 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 329
             ++ +   +G G++G+V +G ++     VAVK +K D    + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248

Query: 330 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388
           VQLLGV   E    YIVTEYM  G+L+DYLR   R  +    LL  +  +  AMEYLE  
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308

Query: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448
           NF+HRDLAARN LV E++V KV+DFGL++  +    T     K P+KWTAPE+L    FS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364

Query: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508
            KSDVW+FG+LLWEI ++G  PYP I L  V   +EKGY+M+ P+GCPP VYE+M+ CW 
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424

Query: 509 WSPADRPSFAETHQAFE 525
              A RPSF +  +  E
Sbjct: 425 LDAAMRPSFLQLREQLE 441


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  305 bits (781), Expect = 2e-82
 Identities = 173/432 (40%), Positives = 247/432 (57%), Gaps = 17/432 (3%)

Query: 94  PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ---GWVPSNYITPV 150
           P LF+ALYDF A     LS+ +G++L  L   + G +   R  +GQ   G VP  ++   
Sbjct: 53  PQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGLVPITHVAKA 110

Query: 151 N--SLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYR 206
           +  +L    WY   VSR+ A+ LL S  N  G+FL+R SESS G  S+S+R + +V HYR
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170

Query: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 266
           ++  ADG +Y+     F  L EL+ ++      +   L        +P +   +P  D W
Sbjct: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL-------QPCMPQKAPRQDVW 223

Query: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
           E   ++  +  KLG G +GEV+ G+W   SL VA+K +K   M++ +  KE   +K ++H
Sbjct: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282

Query: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
             L++L  VC+   P YIVTE M  GNL  +L       +    LL  A Q++  M YLE
Sbjct: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342

Query: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
           ++  +HRDLAARN LV +    KVADFGL+RL+  D Y+  + +K P+KWTAPE+  Y  
Sbjct: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402

Query: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
           FS KSDVW+FGVLL E+ TYG  PY G+   +    + +GYR+ +P  CP +VY LM  C
Sbjct: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462

Query: 507 WKWSPADRPSFA 518
           W+ SP +RPSFA
Sbjct: 463 WRSSPEERPSFA 474


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  305 bits (780), Expect = 2e-82
 Identities = 174/471 (36%), Positives = 271/471 (57%), Gaps = 24/471 (5%)

Query: 66  GC---DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVL 122
           GC   D    A  + +  + ++N     E +  + +ALYD+  +    L++ + E+  +L
Sbjct: 142 GCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLL 201

Query: 123 GYNQNGEWSEVRSKNG-QGWVPSNYITPV--NSLEKHSWYHGPVSRSAAE-YLLSSLING 178
             ++   W  V+ +NG +G+VPS+Y+     N+LE + WY+  +SR  AE  LL +   G
Sbjct: 202 DSSEI-HWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEG 260

Query: 179 SFLVRESESSPGQLSISLRYEGRVY-------HYRINTTADG--KVYVTAESRFSTLAEL 229
           +F+VR+S ++ G  ++S+  +  V        HY I  T D   + YV  +  F ++  L
Sbjct: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319

Query: 230 VHHHSTVADGLVTTLHYPA--PKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV 287
           +++H     GLVT L YP    +   P   G+   + KW ++ +++T   ++G GQ+G V
Sbjct: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR--YGKWVIDPSELTFVQEIGSGQFGLV 377

Query: 288 YVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 347
           ++G W      VA+KT++E  M  E+F++EA VM ++ HP LVQL GVC  + P  +V E
Sbjct: 378 HLGYWLNKD-KVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFE 436

Query: 348 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV 407
           +M +G L DYLR   R    A  LL M   +   M YLE+   IHRDLAARNCLVGEN V
Sbjct: 437 FMEHGCLSDYLRT-QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQV 495

Query: 408 VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG 467
           +KV+DFG++R +  D YT+  G KFP+KW +PE  +++ +S KSDVW+FGVL+WE+ + G
Sbjct: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555

Query: 468 MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 518
             PY     S+V + +  G+R+ +P      VY++M  CWK  P DRP+F+
Sbjct: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFS 606


>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score =  295 bits (754), Expect = 2e-79
 Identities = 178/450 (39%), Positives = 246/450 (54%), Gaps = 57/450 (12%)

Query: 96  LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
           LFVALYD+ A  ++ LS  KGEK ++L  ++ G+W E RS      G++PSNY+ PV+S+
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
           +   WY G + R  AE  L S  N  G+FL+RESE++ G            Y   I    
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKG-----------AYSLSIRDWD 193

Query: 212 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT 271
           D K                       D +    HY   K +    Y    I  + + E  
Sbjct: 194 DMK----------------------GDHVK---HYKIRKLDNGGYY----ITTRAQFETL 224

Query: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 331
              ++H          Y G W   +  VA+KTLK  TM  E FL+EA +MK++KH  LVQ
Sbjct: 225 QQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 273

Query: 332 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 391
           L  V + E P YIVTEYM  G+LLD+L++     +    L+ MA Q+++ M Y+E+ N+I
Sbjct: 274 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 332

Query: 392 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 451
           HRDL + N LVG   + K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  F+IKS
Sbjct: 333 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 392

Query: 452 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 511
           DVW+FG+LL E+ T G  PYPG++  +V + +E+GYRM  P+ CP  ++ELM  CWK  P
Sbjct: 393 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 452

Query: 512 ADRPSFAETHQAFETMFHDSSISEEVAEEL 541
            +RP+F       E  F  +    +  E L
Sbjct: 453 EERPTFEYLQSFLEDYFTATEPQYQPGENL 482


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,475,786
Number of Sequences: 37866
Number of extensions: 2615401
Number of successful extensions: 16220
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 724
Number of HSP's successfully gapped in prelim test: 592
Number of HSP's that attempted gapping in prelim test: 11810
Number of HSP's gapped (non-prelim): 3017
length of query: 1167
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1054
effective length of database: 13,968,660
effective search space: 14722967640
effective search space used: 14722967640
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.