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Search of human proteins with 151108509
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
(818 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 1631 0.0
gi|54860079 nadrin isoform 1 [Homo sapiens] 696 0.0
gi|54860105 nadrin isoform 2 [Homo sapiens] 665 0.0
gi|85815829 SH3-domain binding protein 1 [Homo sapiens] 464 e-130
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 122 1e-27
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 122 2e-27
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 122 2e-27
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 120 5e-27
gi|33356170 myosin IXB isoform 1 [Homo sapiens] 112 1e-24
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 109 1e-23
gi|194272142 myosin IXB isoform 2 [Homo sapiens] 107 3e-23
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 105 2e-22
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 104 3e-22
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens] 104 4e-22
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap... 103 8e-22
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 103 8e-22
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens] 102 1e-21
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 100 4e-21
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 99 2e-20
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 99 2e-20
gi|4505507 oligophrenin 1 [Homo sapiens] 99 2e-20
gi|23510413 sorting nexin 26 [Homo sapiens] 97 5e-20
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens] 97 5e-20
gi|156119615 myosin IXA [Homo sapiens] 97 6e-20
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 95 2e-19
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 95 2e-19
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 95 2e-19
gi|208022687 GTPase regulator associated with the focal adhesion... 95 3e-19
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 94 4e-19
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 94 4e-19
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 1631 bits (4223), Expect = 0.0
Identities = 818/818 (100%), Positives = 818/818 (100%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA
Sbjct: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
Query: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV
Sbjct: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
Query: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180
IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR
Sbjct: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180
Query: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI
Sbjct: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
Query: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300
KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK
Sbjct: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300
Query: 301 KLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL 360
KLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL
Sbjct: 301 KLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL 360
Query: 361 QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT 420
QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT
Sbjct: 361 QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT 420
Query: 421 EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA 480
EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA
Sbjct: 421 EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA 480
Query: 481 DRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAP 540
DRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAP
Sbjct: 481 DRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAP 540
Query: 541 PSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSA 600
PSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSA
Sbjct: 541 PSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSA 600
Query: 601 QKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVPF 660
QKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVPF
Sbjct: 601 QKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVPF 660
Query: 661 GQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSVFT 720
GQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSVFT
Sbjct: 661 GQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSVFT 720
Query: 721 STLSKSRPTPKPRQRPTLPPPQPPTVNLSASSPQSTEAPMLDGMSPGESMSTDLVHFDIP 780
STLSKSRPTPKPRQRPTLPPPQPPTVNLSASSPQSTEAPMLDGMSPGESMSTDLVHFDIP
Sbjct: 721 STLSKSRPTPKPRQRPTLPPPQPPTVNLSASSPQSTEAPMLDGMSPGESMSTDLVHFDIP 780
Query: 781 SIHIELGSTLRLSPLEHMRRHSVTDKRDSEEESESTAL 818
SIHIELGSTLRLSPLEHMRRHSVTDKRDSEEESESTAL
Sbjct: 781 SIHIELGSTLRLSPLEHMRRHSVTDKRDSEEESESTAL 818
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 696 bits (1795), Expect = 0.0
Identities = 393/772 (50%), Positives = 503/772 (65%), Gaps = 49/772 (6%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
MKKQFNRM+QLANQTVGRAEKTEVLSEDLLQ+E+RL+ V+ + H +HK+L AC QGQ G
Sbjct: 1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60
Query: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
+A++R KKLPLT LAQ + E S L +D+LLGKML+ CG+ E++LA EL E+ VE+++
Sbjct: 61 DAERRHKKLPLTALAQNMQEASTQL-EDSLLGKMLETCGDAENQLALELSQHEVFVEKEI 119
Query: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180
++PL+ +AEVEIPNIQKQRK LA+LVLD DS R RW Q KSSG ++ Q +K D L+
Sbjct: 120 VDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSG--TNFQGLPSKIDTLK 177
Query: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
EEM+EA N+VE C+DQL+ADMY+F+AKE +Y +F TL+E QA+YHRK+L +L+ LP++
Sbjct: 178 EEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEM 237
Query: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300
+A Q+ W EKP+FG PLEEHL SGREIA PIEACV +LLE GM+EEGLFR+ ASKLK
Sbjct: 238 RAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLK 297
Query: 301 KLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL 360
KLKAALDC + E+ +DPHA+AGALKSYLRELPEPLMTF LY+EW Q ++VQ+QDKKL
Sbjct: 298 KLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKL 357
Query: 361 QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT 420
Q LW C+KLP N N RYLIKFL+KL++ DVNKMTPSN+AIVLGPNLLW + EG +
Sbjct: 358 QDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLA 417
Query: 421 EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA 480
EM S+ +V +IEPIIQHADWFFP E+EFN++ + + N ++ + D
Sbjct: 418 EMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTL 477
Query: 481 DRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAP 540
+R +RP S+A + L K +S GV++MD RRG + RK
Sbjct: 478 ER------KRPASMAV--------MEGDLVKKESFGVKLMDFQ-AHRRGGTLNRK--HIS 520
Query: 541 PSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALS-----PSGLG-LQPGPERTSTTKSKE 594
P+ QPP PP + + +P+ PE P S A + S PS G L+ GP + K
Sbjct: 521 PAFQPPLPPTDGSTVVPAG-PEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKP 579
Query: 595 LSPGSAQKGSPGSSQGTACAG-TQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAP 653
P SA +PG + +G QP A G+ + P A SPHTLR+ KK AP
Sbjct: 580 KDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHN-AAGPSPHTLRRAVKKPAP 638
Query: 654 IPPK---VPFGQPGAMADQSAGQPSPVSLSPTPPS-TPSPYGLSYPQGYSLASGQLSPAA 709
PPK P G PG + Q P SLSP PP+ +PSP Q GQ P+A
Sbjct: 639 APPKPGNPPPGHPGGQSSSGTSQ-HPPSLSPKPPTRSPSP----PTQHTGQPPGQ--PSA 691
Query: 710 APPLASPSVFTSTLSKSRPTPKPRQRPTLPPPQPPT--VNLSASSPQSTEAP 759
L++P ++S+LS P Q P PPPQPPT L + P S P
Sbjct: 692 PSQLSAPRRYSSSLS-------PIQAPNHPPPQPPTQATPLMHTKPNSQGPP 736
Score = 36.2 bits (82), Expect = 0.13
Identities = 36/115 (31%), Positives = 47/115 (40%), Gaps = 17/115 (14%)
Query: 541 PSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGL-QPG--PERTSTTKSKE--- 594
P+ PP PP + A PL P P P PS GL QP P +T T S
Sbjct: 711 PNHPPPQPPTQ-ATPLMHTKPNS--QGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLG 767
Query: 595 ------LSPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHT 643
+P + G+P ++Q AGT P +P +P PS PP H+
Sbjct: 768 KQNPSLPAPQTLAGGNPETAQ--PHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHS 820
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 665 bits (1715), Expect = 0.0
Identities = 389/819 (47%), Positives = 499/819 (60%), Gaps = 67/819 (8%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
MKKQFNRM+QLANQTVGRAEKTEVLSEDLLQ+E+RL+ V+ + H +HK+L AC QGQ G
Sbjct: 1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60
Query: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
+A++R KKLPLT LAQ + E S L +D+LLGKML+ CG+ E++LA EL E+ VE+++
Sbjct: 61 DAERRHKKLPLTALAQNMQEASTQL-EDSLLGKMLETCGDAENQLALELSQHEVFVEKEI 119
Query: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180
++PL+ +AEVEIPNIQKQRK LA+LVLD DS R RW Q KSSG ++ Q +K D L+
Sbjct: 120 VDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSG--TNFQGLPSKIDTLK 177
Query: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
EEM+EA N+VE C+DQL+ADMY+F+AKE +Y +F TL+E QA+YHRK+L +L+ LP++
Sbjct: 178 EEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEM 237
Query: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300
+A Q+ W EKP+FG PLEEHL SGREIA PIEACV +LLE GM+EEGLFR+ ASKLK
Sbjct: 238 RAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLK 297
Query: 301 KLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL 360
KLKAALDC + E+ +DPHA+AGALKSYLRELPEPLMTF LY+EW Q ++VQ+QDKKL
Sbjct: 298 KLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKL 357
Query: 361 QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT 420
Q LW C+KLP N N RYLIKFL+KL++ DVNKMTPSN+AIVLGPNLLW + EG +
Sbjct: 358 QDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLA 417
Query: 421 EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA 480
EM S+ +V +IEPIIQHADWFFP E+EFN++ + + N ++ + D
Sbjct: 418 EMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTL 477
Query: 481 DRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQ---SMGVRVMDTNWVARRGSSAGRKVS 537
+R +RP S+A M + KK+ K + S V N ++ S + +
Sbjct: 478 ER------KRPASMAV--MEGDLVKKESPPKPKDPVSAAVPAPGRN-NSQIASGQNQPQA 528
Query: 538 CAPPSMQPPAPPAELAAPLPSPL---PEQPLDSPAAPALSPSGLGLQPGPERTSTTKSKE 594
A P A P P L ++P +P P P G PG + +S T
Sbjct: 529 AAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPG---HPGGQSSSGTSQ-- 583
Query: 595 LSPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPI 654
P S P S TQ QP QP A S P R+ S L+PI
Sbjct: 584 -HPPSLSPKPPTRSPSPP---TQHTGQPPGQPSAPSQLSAP---------RRYSSSLSPI 630
Query: 655 -PPKVPFGQPGAMA-------DQSAGQPSPVSL---------------SPTPPSTPSPYG 691
P P QP A S G P+P++L +PTPPSTP P G
Sbjct: 631 QAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTP-PLG 689
Query: 692 LSYPQGYSLASGQLSPAAAPPLASPSVFTSTLSKSRPTPKPRQRPTL-PPPQPPTVNLSA 750
P SL + Q P A P TL + RP PKPR RP++ PPPQPP V+ +
Sbjct: 690 KQNP---SLPAPQTLAGGNPETAQP--HAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAG 744
Query: 751 SSPQSTEAPMLDGMSPGESMSTDLVHFDI-PSIHIELGS 788
S + AP + + H I P +H + S
Sbjct: 745 DSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSDSAS 783
>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
Length = 701
Score = 464 bits (1193), Expect = e-130
Identities = 295/737 (40%), Positives = 413/737 (56%), Gaps = 75/737 (10%)
Query: 1 MKKQFNRMRQLANQ-TVGRAEKT-EVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQ 58
MK+Q +RMRQLA ++GR +T E L EDLLQVE+RLE K+ +H+ HK+L ACLQGQ
Sbjct: 2 MKRQLHRMRQLAQTGSLGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQS 61
Query: 59 GAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVER 118
GA+ DKR KKLPL L+ + E L D+ +GK L++ +++LA+ L FE+ +ER
Sbjct: 62 GADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLER 121
Query: 119 DVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGA---- 174
DV++PL L+E E+P I K +K L KLV D ++ ++R Q +K+SG S L +
Sbjct: 122 DVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHSH 181
Query: 175 -----KADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKS 229
K + L+EE EE +VE CRD+ AD+Y FV KE YANYF L+E+QA+YHR+S
Sbjct: 182 TTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRRS 241
Query: 230 LTLLQAVLPQIKAQQEAWVEKPS---------FGKPLEEHLTISGREIAFPIEACVTMLL 280
L+ L L +++ PS +G L HL GREIA PIEACV MLL
Sbjct: 242 LSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMMLL 301
Query: 281 ECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMT 340
GM+EEGLFR+A AS LK+LK + ++E+ +DPHA+AGALKSYLRELPEPLMT
Sbjct: 302 SEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMT 361
Query: 341 FELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPS 400
F+LYD+W++A++++E +LQAL C +LP N +N+RYL+KFL++L+E Q+VNKMTPS
Sbjct: 362 FDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPS 421
Query: 401 NMAIVLGPNLLW-PQAEGNITEM--MTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNY 457
N+AIVLGPNLLW P+ EG+ ++ + S+Q+VG++E +IQ AD FPG+I FN++G +
Sbjct: 422 NIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGLF 481
Query: 458 G--------SPVHVNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGL 509
S + +++P+P PA P A P
Sbjct: 482 SAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAP------------------ 523
Query: 510 RKIQSMGVRVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPEQPLDSP- 568
+ S + + V R +S KV+ +PP + AP ++A P P +P P
Sbjct: 524 -ALASAATKERTESEVPPRPASP--KVTRSPP--ETAAPVEDMARRTKRPAPARPTMPPP 578
Query: 569 --AAPALSPSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGAQP 626
+ SP L PG T ++ + +P QP + +
Sbjct: 579 QVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRS 638
Query: 627 GASPSPSQP-PADQSPHTLRKVSKKLAPIPPKVPFGQPGAMADQSAGQPSPVSLSPTPPS 685
ASPSP+ P PA SP +L P +V G A G P +S PTPP+
Sbjct: 639 PASPSPASPGPASPSPVSLSN--------PAQVDLG----AATAEGGAPEAISGVPTPPA 686
Query: 686 TPSPYGLSYPQGYSLAS 702
P P+ SLAS
Sbjct: 687 IP-----PQPRPRSLAS 698
Score = 43.9 bits (102), Expect = 6e-04
Identities = 47/181 (25%), Positives = 65/181 (35%), Gaps = 22/181 (12%)
Query: 569 AAPALSPSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGA 628
+A L P + ++ T +S A + P ++ T P P P
Sbjct: 464 SADTLFPGDINFNVSGLFSAVTLQDTVSDRLASEELPSTAVPT------PATTPAPAPAP 517
Query: 629 SPSPSQPPADQSPHTLRKVSKKLAPIP--PKVPFGQPGAMADQSAGQPSPVSLSPTPPST 686
+P+P+ PA S T + ++ P P PKV P A +P P+
Sbjct: 518 APAPA--PALASAATKERTESEVPPRPASPKVTRSPPETAAPVEDMARRTKRPAPARPTM 575
Query: 687 PSPYGLSYPQGYSLASGQLSPAAAPPL--ASPSVFTSTLSKSRPTPKPRQRPTLPPPQPP 744
P P SG S APPL S S T R + PT+PPP PP
Sbjct: 576 PPPQ----------VSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRAPTVPPPLPP 625
Query: 745 T 745
T
Sbjct: 626 T 626
Score = 42.7 bits (99), Expect = 0.001
Identities = 39/115 (33%), Positives = 55/115 (47%), Gaps = 17/115 (14%)
Query: 666 MADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGY----SLASGQLSPAAAPPL-ASPSVFT 720
++D+ A + P + PTP +TP+P P S A+ + + + PP ASP V
Sbjct: 490 VSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTR 549
Query: 721 STLSKSRP-------TPKPRQ-RPTLPPPQPPTVNLSASSPQSTEAPMLDGMSPG 767
S + P T +P RPT+PPPQ V+ S SSP + P G SPG
Sbjct: 550 SPPETAAPVEDMARRTKRPAPARPTMPPPQ---VSGSRSSPPAPPLPPGSG-SPG 600
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 122 bits (306), Expect = 1e-27
Identities = 70/207 (33%), Positives = 119/207 (57%), Gaps = 8/207 (3%)
Query: 250 KPSFGKPLEEHLTIS---GREIA-FPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAA 305
K FG+ LE+ + G +A +E CV + + G++EEGLFR+ A+ +K+L+ A
Sbjct: 37 KGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDA 96
Query: 306 LDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNV--QEQDKKLQAL 363
DC + + D H +A LK YLRELPEP++ + Y++++ + + +E++ ++ L
Sbjct: 97 FDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKEL 156
Query: 364 WNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMM 423
+ LP N+N ++Y+ +FL ++ Y VNKM+ N+A V GPN+L P+ E +T M
Sbjct: 157 AKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIME 216
Query: 424 TTVSLQIVGIIEPIIQHADWFFPGEIE 450
TV +Q ++ +I D FP + E
Sbjct: 217 GTVVVQ--QLMSVMISKHDCLFPKDAE 241
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 122 bits (305), Expect = 2e-27
Identities = 69/204 (33%), Positives = 118/204 (57%), Gaps = 8/204 (3%)
Query: 253 FGKPLEEHLTIS---GREIA-FPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDC 308
FG+ LE+ + G +A +E CV + + G++EEGLFR+ A+ +K+L+ A DC
Sbjct: 38 FGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDC 97
Query: 309 CVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNV--QEQDKKLQALWNA 366
+ + D H +A LK YLRELPEP++ + Y++++ + + +E++ ++ L
Sbjct: 98 GEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQ 157
Query: 367 CEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTV 426
+ LP N+N ++Y+ +FL ++ Y VNKM+ N+A V GPN+L P+ E +T M TV
Sbjct: 158 VKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTV 217
Query: 427 SLQIVGIIEPIIQHADWFFPGEIE 450
+Q ++ +I D FP + E
Sbjct: 218 VVQ--QLMSVMISKHDCLFPKDAE 239
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 122 bits (305), Expect = 2e-27
Identities = 69/204 (33%), Positives = 118/204 (57%), Gaps = 8/204 (3%)
Query: 253 FGKPLEEHLTIS---GREIA-FPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDC 308
FG+ LE+ + G +A +E CV + + G++EEGLFR+ A+ +K+L+ A DC
Sbjct: 133 FGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDC 192
Query: 309 CVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNV--QEQDKKLQALWNA 366
+ + D H +A LK YLRELPEP++ + Y++++ + + +E++ ++ L
Sbjct: 193 GEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQ 252
Query: 367 CEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTV 426
+ LP N+N ++Y+ +FL ++ Y VNKM+ N+A V GPN+L P+ E +T M TV
Sbjct: 253 VKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTV 312
Query: 427 SLQIVGIIEPIIQHADWFFPGEIE 450
+Q ++ +I D FP + E
Sbjct: 313 VVQ--QLMSVMISKHDCLFPKDAE 334
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 120 bits (301), Expect = 5e-27
Identities = 70/183 (38%), Positives = 107/183 (58%), Gaps = 6/183 (3%)
Query: 253 FGKPLEE---HLTISGREIA-FPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDC 308
FG+ LEE H G +A +E CV + E G+ EEGLFR+ A+ ++ L+ + DC
Sbjct: 153 FGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDC 212
Query: 309 CVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNA-- 366
+ + + D H +A LK YLRELPEP++ F Y++++ + + +D+ L A
Sbjct: 213 GEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQ 272
Query: 367 CEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTV 426
LP+AN+N +RY+ KFL ++ Y +VNKM+ N+A V GPN+L PQ E +T M T
Sbjct: 273 VSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTS 332
Query: 427 SLQ 429
+Q
Sbjct: 333 LVQ 335
>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
Length = 2157
Score = 112 bits (281), Expect = 1e-24
Identities = 129/501 (25%), Positives = 206/501 (41%), Gaps = 77/501 (15%)
Query: 245 EAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKA 304
E VE FG ++ LT + +E + + G+ EGL+R + +A++ ++L+
Sbjct: 1690 EPGVEPGHFGVCVDS-LTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQ 1748
Query: 305 ALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALW 364
AL V+ + HAI G LK +LRELPEPLMTF Y ++++A + E+ ++L A++
Sbjct: 1749 ALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIY 1808
Query: 365 NACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLL-WPQAEGNITEMM 423
E LP+ANHN++ LI L K++ +DVN+M+P +AI+ P LL P +T M
Sbjct: 1809 AVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMK 1868
Query: 424 TTVSLQIVGIIEPIIQHADWFFPGEIE----------------FNITGNYGSPVHVNHNA 467
L+I +E +I+ + ++E + N P+ + ++
Sbjct: 1869 DV--LKITTCVEMLIKEQMRKYKVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSS 1926
Query: 468 NYSSMPSPDMDPADRRQPE-------------QARRPLSVATDNMMLEFYKKDGLRKIQS 514
Y + + D ++ E + R + ++ K+D ++
Sbjct: 1927 PYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKEDITYRLPE 1986
Query: 515 MGVRVMDTNWVARRGSSA---------GRKVSCAPPSMQPPAPPAELAAPLPSPLPEQPL 565
+ R D + S++ GR S PP+ P P AP PSPLP
Sbjct: 1987 LDPRGSDEENLDSETSASTESLLEERAGRGASEGPPAPALPCP----GAPTPSPLP---- 2038
Query: 566 DSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGAQ 625
A P PS R T + + P + K PG P PGA+
Sbjct: 2039 TVAAPPRRRPSSF----VTVRVKTPRRTPIMPTANIKLPPG------LPSHLPRWAPGAR 2088
Query: 626 PGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVPFGQPGAMADQSAGQPSPVSLSPTPPS 685
A+P + P + P + V I P GA+ P+ PP
Sbjct: 2089 EAAAPVRRREPPARRPDQIHSVY-----ITPGADLPVQGAL--------EPLEEDGQPPG 2135
Query: 686 TPSPYGLSYPQGYSL--ASGQ 704
Y S P Y L ASGQ
Sbjct: 2136 AKRRY--SDPPTYCLPPASGQ 2154
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 109 bits (272), Expect = 1e-23
Identities = 128/537 (23%), Positives = 226/537 (42%), Gaps = 72/537 (13%)
Query: 252 SFGKPLEE-HLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCV 310
+FG LEE + + + AC ++ G++ G++RV + + + L+ L+
Sbjct: 808 AFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGP 867
Query: 311 VDVQ---EYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNAC 367
D+ E D + I+ LKS+ R+LPEPL T + Y+++I+A+ +++ ++++ L
Sbjct: 868 GDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLI 927
Query: 368 EKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVS 427
LP + +++L+ L ++++ + NKM P N+A+V GP L+ +E N+T+M+T +
Sbjct: 928 RDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLV-RTSEDNMTDMVTHMP 986
Query: 428 LQIVGIIEPIIQHADWFFPGE-------------------IEFNI--TGNYGSPVHVNHN 466
I+E +IQH+DWFF E IE+ + G P +
Sbjct: 987 -DRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSD 1045
Query: 467 ANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVA 526
+ S A +++P AR L+++ + + KK R+ + +G D +
Sbjct: 1046 STTCSSAKSKGSWAPKKEP-YAREMLAISFISAVNRKRKK--RREARGLGSSTDDDSEQE 1102
Query: 527 RRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPL-PEQP--LDSPAAPALSPSG--LGLQ 581
AG + AP + + P PLP + PE P L PAAP P+ +
Sbjct: 1103 AHKPGAG---ATAPGTQERP------QGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIV 1153
Query: 582 PGPERTSTTKSKELSPGSAQK---GSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPAD 638
G ST S S ++ G + + + + + A G ++ P+
Sbjct: 1154 SGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSF 1213
Query: 639 QSPHTL---RKVSKKLAPIPPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYP 695
S H + ++LA G+P + AG+ P +P PP + S
Sbjct: 1214 SSHHLMPCDTLARRRLAR-------GRPDG---EGAGRGGP--RAPEPPGSAS------- 1254
Query: 696 QGYSLASGQLSPAAAPPLASPSVFTSTLSKSRPTPKPRQRPTLPPPQPPTVNLSASS 752
S + L P AA + PS + + R T L P P SS
Sbjct: 1255 ---SSSQESLRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSS 1308
Score = 36.6 bits (83), Expect = 0.097
Identities = 56/236 (23%), Positives = 84/236 (35%), Gaps = 29/236 (12%)
Query: 530 SSAGRKVSCAPP------SMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPG 583
S R + PP + PPA + A +P P P D + A S GL + P
Sbjct: 82 SGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPA 141
Query: 584 PERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQ---- 639
S + S + SPG+ + P A P +PG+ PS+ Q
Sbjct: 142 ARAHLDNSSLGM---SQPRPSPGAFPHLSSEPRTPRAFP--EPGSRVPPSRLECQQALSH 196
Query: 640 --SPHTLRKVSKKLAP-IPPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGL---- 692
S R+ ++ P + P+ + + +A +P P S S S G
Sbjct: 197 WLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRAR 256
Query: 693 --SYPQGYSLASGQLSPAAAPPLASPSVFTSTLSKSRPTPKPRQRPT--LPPPQPP 744
Y + ++ L P A L SP + R + + PT LP PQ P
Sbjct: 257 SDDYLSRATRSAEALGPGA---LVSPRFERCGWASQRSSARTPACPTRDLPGPQAP 309
>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
Length = 2022
Score = 107 bits (268), Expect = 3e-23
Identities = 68/196 (34%), Positives = 111/196 (56%), Gaps = 4/196 (2%)
Query: 245 EAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKA 304
E VE FG ++ LT + +E + + G+ EGL+R + +A++ ++L+
Sbjct: 1690 EPGVEPGHFGVCVDS-LTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQ 1748
Query: 305 ALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALW 364
AL V+ + HAI G LK +LRELPEPLMTF Y ++++A + E+ ++L A++
Sbjct: 1749 ALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIY 1808
Query: 365 NACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLL-WPQAEGNITEMM 423
E LP+ANHN++ LI L K++ +DVN+M+P +AI+ P LL P +T M
Sbjct: 1809 AVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMK 1868
Query: 424 TTVSLQIVGIIEPIIQ 439
L+I +E +I+
Sbjct: 1869 DV--LKITTCVEMLIK 1882
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 105 bits (261), Expect = 2e-22
Identities = 65/218 (29%), Positives = 116/218 (53%), Gaps = 11/218 (5%)
Query: 264 SGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQ---EYSADP 320
+ R I ++ C ++ E G++ G++RV + + + ++ L+ + D+ + D
Sbjct: 1157 TNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDL 1216
Query: 321 HAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRY 380
+ I+ LKS+ R+LPEPL T + Y ++I+A+ ++ +L+ L LP+ ++ +++
Sbjct: 1217 NVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKF 1276
Query: 381 LIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQH 440
L L ++E + NKM P N+AIV GP L+ +E N+T M+T + Q I+E +IQH
Sbjct: 1277 LSAHLKTVAENSEKNKMEPRNLAIVFGPTLV-RTSEDNMTHMVTHMPDQ-YKIVETLIQH 1334
Query: 441 ADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMD 478
DWFF E G V + S P P++D
Sbjct: 1335 HDWFFTEE------GAEEPLTTVQEESTVDSQPVPNID 1366
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 104 bits (260), Expect = 3e-22
Identities = 76/263 (28%), Positives = 124/263 (47%), Gaps = 15/263 (5%)
Query: 238 PQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSAS 297
P+ + W E FG PL +T + I IE C+ + G+ EG++RV+ + S
Sbjct: 1233 PRPSITKATW-ESNYFGVPLTTVVTPE-KPIPIFIERCIEYIEATGLSTEGIYRVSGNKS 1290
Query: 298 KLKKLKAALDCCV-VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQ 356
+++ L+ D +D+ E + +AGA+KS+ ELP+PL+ + + + ++A + ++
Sbjct: 1291 EMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDR 1350
Query: 357 DKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAE 416
++KL AL +K PK NH +Y+I L+K+S VN MT N++I P L+ P
Sbjct: 1351 EQKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFS 1410
Query: 417 GNITEMMTTVSLQIVGIIEPIIQHADWFF-------PGEIEFNITGNYGSPVHVNHNANY 469
T T + IIE IQ +FF P + S V +
Sbjct: 1411 ---TMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGARPSSPSAVASTVPFLTSTPV 1467
Query: 470 SSMPSPDMDPADRRQPEQARRPL 492
+S PSP P P+ +PL
Sbjct: 1468 TSQPSPPQSPPP--TPQSPMQPL 1488
>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
Length = 2087
Score = 104 bits (259), Expect = 4e-22
Identities = 80/291 (27%), Positives = 146/291 (50%), Gaps = 20/291 (6%)
Query: 226 HRKSLTLLQAVLP----QIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLE 281
H K +T L+ + + K +Q +++ FG L EHL SG E+ +++C +
Sbjct: 339 HGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIER 398
Query: 282 CGMQEEGLFRVAPSASKLKKLKAALDC-CVVDV--QEYSADPHAIAGALKSYLRELPEPL 338
G+ + G++R++ AS +++L+ D V D+ + Y D H++ K Y RELP PL
Sbjct: 399 YGIVD-GIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPL 457
Query: 339 MTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMT 398
+T++LY+++ A + +++L + + ++LP ++ + +L++ LS L++Y + M
Sbjct: 458 LTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMH 517
Query: 399 PSNMAIVLGPNLLWPQ----AEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNIT 454
N+AIV PNLL + A + T V +Q V ++E I+ H D F G I ++
Sbjct: 518 AKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSV-VVEFILNHVDVLFSGRI--SMA 574
Query: 455 GNYGSPVHVNHNANYSSMPSP---DMDPADRRQPEQARRPLSVATDNMMLE 502
G+ + S PS ++ A R Q P + T+N +E
Sbjct: 575 MQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVNSP--IVTENKYIE 623
>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
sapiens]
Length = 890
Score = 103 bits (256), Expect = 8e-22
Identities = 126/498 (25%), Positives = 217/498 (43%), Gaps = 45/498 (9%)
Query: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300
K +++ ++ FG L+EHL SG+E+ +++C + E G+ + G++R++ +S ++
Sbjct: 6 KGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQ 64
Query: 301 KLKAALDC-CVVDVQE--YSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQD 357
KL+ + D++ Y D H ++ K+Y RELP+PL+T+ LYD++ +A VQ +
Sbjct: 65 KLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEP 124
Query: 358 KKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWP---Q 414
++L + +LP N+ + +L++ L ++ + M N+AIV PNLL +
Sbjct: 125 ERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIE 184
Query: 415 AEG-NITEMMTTVSLQIVGIIEPIIQHADWFF------PGEIEFNI-----TGNYGSPVH 462
A G N T V +Q + ++E I+ H D F GE+E T GSP
Sbjct: 185 ASGFNGTAAFMEVRVQSI-VVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPED 243
Query: 463 VNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGL-----RKIQSMGV 517
+ +PS + A P+ RP + + E +K L R I ++G
Sbjct: 244 LMPRPLPYHLPS--ILQAGDGPPQM--RPYHTIIE--IAEHKRKGSLKVRKWRSIFNLGR 297
Query: 518 RVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSG 577
+T RG+ R+ +++P L+A + + L P++P SP
Sbjct: 298 SGHETKRKLPRGAE-DREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPL- 355
Query: 578 LGLQPGPERTSTTKSK-ELSPGSAQKGSPGSSQGTACAG---TQPGAQPGAQPGASPSPS 633
L E S ++ E P + G S GT AG + G A+ A S
Sbjct: 356 --LPESLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHIS 413
Query: 634 QPPADQSPHTLRKVSKKLAPIPPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLS 693
P P + + +PP + A + P+ + P+P S P P G
Sbjct: 414 DPYNVNLPLHITSI----LSVPPNIISNVSLARLTRGLECPA-LQHRPSPASGPGP-GPG 467
Query: 694 YPQGYSLASGQLSPAAAP 711
G + SPA++P
Sbjct: 468 LGPGPPDEKLEASPASSP 485
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 103 bits (256), Expect = 8e-22
Identities = 126/498 (25%), Positives = 217/498 (43%), Gaps = 45/498 (9%)
Query: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300
K +++ ++ FG L+EHL SG+E+ +++C + E G+ + G++R++ +S ++
Sbjct: 6 KGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQ 64
Query: 301 KLKAALDC-CVVDVQE--YSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQD 357
KL+ + D++ Y D H ++ K+Y RELP+PL+T+ LYD++ +A VQ +
Sbjct: 65 KLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEP 124
Query: 358 KKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWP---Q 414
++L + +LP N+ + +L++ L ++ + M N+AIV PNLL +
Sbjct: 125 ERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIE 184
Query: 415 AEG-NITEMMTTVSLQIVGIIEPIIQHADWFF------PGEIEFNI-----TGNYGSPVH 462
A G N T V +Q + ++E I+ H D F GE+E T GSP
Sbjct: 185 ASGFNGTAAFMEVRVQSI-VVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPED 243
Query: 463 VNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGL-----RKIQSMGV 517
+ +PS + A P+ RP + + E +K L R I ++G
Sbjct: 244 LMPRPLPYHLPS--ILQAGDGPPQM--RPYHTIIE--IAEHKRKGSLKVRKWRSIFNLGR 297
Query: 518 RVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSG 577
+T RG+ R+ +++P L+A + + L P++P SP
Sbjct: 298 SGHETKRKLPRGAE-DREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPL- 355
Query: 578 LGLQPGPERTSTTKSK-ELSPGSAQKGSPGSSQGTACAG---TQPGAQPGAQPGASPSPS 633
L E S ++ E P + G S GT AG + G A+ A S
Sbjct: 356 --LPESLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHIS 413
Query: 634 QPPADQSPHTLRKVSKKLAPIPPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLS 693
P P + + +PP + A + P+ + P+P S P P G
Sbjct: 414 DPYNVNLPLHITSI----LSVPPNIISNVSLARLTRGLECPA-LQHRPSPASGPGP-GPG 467
Query: 694 YPQGYSLASGQLSPAAAP 711
G + SPA++P
Sbjct: 468 LGPGPPDEKLEASPASSP 485
>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
Length = 1738
Score = 102 bits (255), Expect = 1e-21
Identities = 76/272 (27%), Positives = 138/272 (50%), Gaps = 16/272 (5%)
Query: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300
K +Q +++ FG L EHL SG E+ +++C + G+ + G++R++ AS ++
Sbjct: 9 KLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQ 67
Query: 301 KLKAALDC-CVVDV--QEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQD 357
+L+ D V D+ + Y D H++ K Y RELP PL+T++LY+++ A + +
Sbjct: 68 RLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDE 127
Query: 358 KKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQ--- 414
++L + + ++LP ++ + +L++ LS L++Y + M N+AIV PNLL +
Sbjct: 128 ERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIE 187
Query: 415 -AEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMP 473
A + T V +Q V ++E I+ H D F G I ++ G+ + S P
Sbjct: 188 SACFSGTAAFMEVRIQSV-VVEFILNHVDVLFSGRI--SMAMQEGAASLSRPKSLLVSSP 244
Query: 474 SP---DMDPADRRQPEQARRPLSVATDNMMLE 502
S ++ A R Q P + T+N +E
Sbjct: 245 STKLLTLEEAQARTQAQVNSP--IVTENKYIE 274
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 100 bits (250), Expect = 4e-21
Identities = 107/406 (26%), Positives = 169/406 (41%), Gaps = 87/406 (21%)
Query: 272 IEACVTMLLECGMQEEGLFRVAPSASKLKKLKAAL----DCCVVDVQEYSAD--PHAIAG 325
I C++ + G+ ++GL+RV +SK+++L + L C VD+ E SAD I
Sbjct: 399 IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDL-ENSADWEVKTITS 457
Query: 326 ALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFL 385
ALK YLR LPEPLMT+EL+ ++I + + ++ A+ KLP+ N + L+K L
Sbjct: 458 ALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHL 517
Query: 386 SKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFF 445
+ +S + N MT +N+ +V GP L+ PQ E + +M IV +E +I++ + F
Sbjct: 518 TNVSNHSKQNLMTVANLGVVFGPTLMRPQEE-TVAALMDLKFQNIV--VEILIENHEKIF 574
Query: 446 --PGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDP-ADRRQPEQARRPLSVATDNMMLE 502
P + F S P+ P +RQ ++ +RP VA N+ LE
Sbjct: 575 RTPPDTTF-------------PEPTCLSASPPNAPPRQSKRQGQRTKRP--VAVYNLCLE 619
Query: 503 FYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPE 562
D P P E P
Sbjct: 620 LEDGDN-------------------------------------PYPSKE-------DTPT 635
Query: 563 QPLDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQP---- 618
LDS ++P+ + + PGP++ S G PG ++ + P
Sbjct: 636 SSLDSLSSPSPVTTAVPGPPGPDKNHLLADGG-SFGDWASTIPGQTRSSMVQWLNPQSPT 694
Query: 619 -----GAQPGAQPGASPSPSQPP---ADQSPHTLRKVSKKLAPIPP 656
A PG+SP P PP AD+ P ++R S+K + P
Sbjct: 695 TTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIR--SRKARAVYP 738
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 99.0 bits (245), Expect = 2e-20
Identities = 59/203 (29%), Positives = 111/203 (54%), Gaps = 6/203 (2%)
Query: 249 EKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDC 308
E FG PL++ +T + I +E CV + + G+ EGL+RV+ + + ++ D
Sbjct: 1256 ESNYFGMPLQDLVTAE-KPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQ 1314
Query: 309 CV-VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNAC 367
+++ +A+AGALK++ +LP+PL+ + L+ E ++A+ + ++ ++L AL
Sbjct: 1315 DHNINLVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIV 1374
Query: 368 EKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVS 427
+K N++ RY+I L+++S+ +N MT N++I P L+ P E E ++T
Sbjct: 1375 KKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFENR--EFLSTTK 1432
Query: 428 LQIVGIIEPIIQHADWFF-PGEI 449
+ ++E IQ +FF GEI
Sbjct: 1433 IH-QSVVETFIQQCQFFFYNGEI 1454
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 99.0 bits (245), Expect = 2e-20
Identities = 59/203 (29%), Positives = 111/203 (54%), Gaps = 6/203 (2%)
Query: 249 EKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDC 308
E FG PL++ +T + I +E CV + + G+ EGL+RV+ + + ++ D
Sbjct: 1255 ESNYFGMPLQDLVTAE-KPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQ 1313
Query: 309 CV-VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNAC 367
+++ +A+AGALK++ +LP+PL+ + L+ E ++A+ + ++ ++L AL
Sbjct: 1314 DHNINLVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIV 1373
Query: 368 EKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVS 427
+K N++ RY+I L+++S+ +N MT N++I P L+ P E E ++T
Sbjct: 1374 KKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFENR--EFLSTTK 1431
Query: 428 LQIVGIIEPIIQHADWFF-PGEI 449
+ ++E IQ +FF GEI
Sbjct: 1432 IH-QSVVETFIQQCQFFFYNGEI 1453
>gi|4505507 oligophrenin 1 [Homo sapiens]
Length = 802
Score = 98.6 bits (244), Expect = 2e-20
Identities = 64/220 (29%), Positives = 113/220 (51%), Gaps = 13/220 (5%)
Query: 241 KAQQEAWVE-----KPSFGKPLEEHLTISGREIAFP-IEACVTMLLECGMQEEGLFRVAP 294
+A + W+E +P + P+ + + E+ F + C+ ++ G++ EGL+R
Sbjct: 353 EANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVG 412
Query: 295 SASKLKKLKAAL--DCCVVDVQEYSAD--PHAIAGALKSYLRELPEPLMTFELYDEWIQA 350
S +++KL A C DV +++D I +LK YLR L EP+MT+ L+ E + A
Sbjct: 413 SNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSA 472
Query: 351 SNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNL 410
+ D +L A+ + KLP+ N + LI+ L + E+ N MTPSNM ++ GP L
Sbjct: 473 AKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTL 532
Query: 411 LWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE 450
+ +A+ + M + Q + ++E +I+H + G E
Sbjct: 533 M--RAQEDTVAAMMNIKFQNI-VVEILIEHFGKIYLGPPE 569
Score = 31.2 bits (69), Expect = 4.1
Identities = 58/222 (26%), Positives = 84/222 (37%), Gaps = 42/222 (18%)
Query: 548 PPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPGPERTST-TKSKELSPGSAQKGSPG 606
PP E AAP P P P A P + + ERT T S + S Q +P
Sbjct: 567 PPEESAAP-PVPPPRV-----TARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPN 620
Query: 607 SSQGTACAGTQPGAQP-------GAQPGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVP 659
+ ++ +P P G SPS+P D KL P P +V
Sbjct: 621 GTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDG----------KLEPCP-EVD 669
Query: 660 FGQPGAMADQSAGQPSPVSLS-PTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSV 718
G+ + + +P + + P P S P+ S + A PLA
Sbjct: 670 VGKLVSRLQDGGTKITPKATNGPMPGSGPT----------KTPSFHIKRPAPRPLAHHKE 719
Query: 719 FTS-TLSKSRPTPKPRQRPTL--PPPQPPTVNLSASSPQSTE 757
+ + SK RP P ++PT+ PP +PP A++PQ E
Sbjct: 720 GDADSFSKVRP---PGEKPTIIRPPVRPPDPPCRAATPQKPE 758
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 97.4 bits (241), Expect = 5e-20
Identities = 135/557 (24%), Positives = 217/557 (38%), Gaps = 57/557 (10%)
Query: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300
+ +Q + + FG L EHL+ SG+++ + C + G+ + G++R++ +S ++
Sbjct: 301 RLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVD-GIYRLSGVSSNIQ 359
Query: 301 KLKAALDCCVVDVQEYSA---DPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQD 357
+L+ D + A D H+++ K Y RELP PL+T++LY ++ +A +V ++
Sbjct: 360 RLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEE 419
Query: 358 KKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEG 417
++L + + ++LP ++ + YL++ L++++ + M N+AIV PNLL
Sbjct: 420 ERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELE 479
Query: 418 NI----TEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMP 473
++ V +Q V ++E ++ H D F G + + S P
Sbjct: 480 SVGMGGAAAFREVRVQSV-VVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCP 538
Query: 474 SPDMDPADRRQPEQARR------PLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVAR 527
S + + Q R P + E K + K + G T +
Sbjct: 539 STRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALG 598
Query: 528 RGSSAGRK--VSCAPPSMQPPAPPAEL--AAPLPSPLPEQPLDSPAAPALSPSGLGLQPG 583
RG S RK + + PP P L S E+ L S A+ A L G
Sbjct: 599 RGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAEL-----LGAG 653
Query: 584 PERTSTTKSKELSPGSAQKGS--PGSSQGT------ACAGTQPGAQPGAQPGASP---SP 632
S T + LSPG + + P +G AC GAQ P SP
Sbjct: 654 GAPASATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESP 713
Query: 633 SQPPADQSPHTLRKVSKKLAPIPPKVPFG----QPGAMADQSAGQPSPVSLSPTPPSTPS 688
PP P +L + P PPK P A Q A Q S TPP++ S
Sbjct: 714 LPPP----PLSLLRPG-GAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQS 768
Query: 689 PYGLSYPQGYSLASGQLSPAAAPP--LASPSVFTSTLSKSRPTPKPRQRPTLPPPQPPTV 746
P+ S S + PP LA P + P P LP Q
Sbjct: 769 PFHRSLSLEVGGEPLGTSGSGPPPNSLAHPGAWV-----------PGPPPYLPRQQSDGS 817
Query: 747 NLSASSPQSTEAPMLDG 763
L + P T L G
Sbjct: 818 LLRSQRPMGTSRRGLRG 834
>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
Length = 1444
Score = 97.4 bits (241), Expect = 5e-20
Identities = 61/210 (29%), Positives = 113/210 (53%), Gaps = 13/210 (6%)
Query: 252 SFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAAL---DC 308
+FG L E+L SG+++ + +++C + G+ + G++R++ S +++L+ C
Sbjct: 18 AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSDQC 76
Query: 309 CVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACE 368
+ + Y D H + K Y RELP PL+T+ELY+++ +A + ++ +L + N +
Sbjct: 77 PDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQ 136
Query: 369 KLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWP---QAEG-NITEMMT 424
+LP +++ + YLI+ L+ ++ + M N+A+V PNLL +A G N
Sbjct: 137 ELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFL 196
Query: 425 TVSLQIVGIIEPIIQHADWFF----PGEIE 450
V +Q V +IE I+ H D F PG +E
Sbjct: 197 AVRVQQV-VIEFILNHVDQIFNNGAPGSLE 225
Score = 31.2 bits (69), Expect = 4.1
Identities = 42/183 (22%), Positives = 68/183 (37%), Gaps = 21/183 (11%)
Query: 605 PGSSQGTACAGTQPGAQPGAQPGASPSPSQPPA-DQSPHTLRKVSK----------KLAP 653
P SQ + G QP + P ++ +Q PA D SP +L + K +P
Sbjct: 1215 PLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKEEKPKQDPGAIKSSP 1274
Query: 654 IPPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPL 713
+ P G G + +S + P G +L S +L
Sbjct: 1275 VDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDNLLSSKLE------- 1327
Query: 714 ASPSVFTSTLSKSRPTPKPRQRPTLPPPQPPTVNLSASSPQSTEAPMLDGM-SPGESMST 772
PS + +SRP +P+ PP P +L SS + +L + SP +++S
Sbjct: 1328 -RPSGGSKPFHRSRP-GRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRSPTQTVSP 1385
Query: 773 DLV 775
L+
Sbjct: 1386 GLL 1388
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 97.1 bits (240), Expect = 6e-20
Identities = 51/159 (32%), Positives = 92/159 (57%), Gaps = 1/159 (0%)
Query: 253 FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVD 312
FG L LT R + +E + + G+ EG++R + S +K+K+L+ LD
Sbjct: 2061 FGVELSR-LTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAES 2119
Query: 313 VQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPK 372
V + H IA K +LR+LP PLMTFELY+E+++A +QE+ + ++ +++ ++L +
Sbjct: 2120 VNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSR 2179
Query: 373 ANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLL 411
+ N + LI L +++ +D N+M+ + +AIV P +L
Sbjct: 2180 THLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCIL 2218
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 95.1 bits (235), Expect = 2e-19
Identities = 56/177 (31%), Positives = 100/177 (56%), Gaps = 4/177 (2%)
Query: 272 IEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCV-VDVQEYS-ADPHAIAGALKS 329
++ C+ + G+ +GL+R++ + + ++KL+ +D +D+ + D H I GALK
Sbjct: 346 VQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKL 405
Query: 330 YLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLS 389
+ RELPEPL F + ++I A +Q+Q ++ + + + LP NH+ +R L + L ++
Sbjct: 406 FFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVI 465
Query: 390 EYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFP 446
E+ + N+M+ ++AIV GP LL P+ E M Q+V +I + Q AD F P
Sbjct: 466 EHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELI--LQQCADIFPP 520
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 95.1 bits (235), Expect = 2e-19
Identities = 56/177 (31%), Positives = 100/177 (56%), Gaps = 4/177 (2%)
Query: 272 IEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCV-VDVQEYS-ADPHAIAGALKS 329
++ C+ + G+ +GL+R++ + + ++KL+ +D +D+ + D H I GALK
Sbjct: 373 VQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKL 432
Query: 330 YLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLS 389
+ RELPEPL F + ++I A +Q+Q ++ + + + LP NH+ +R L + L ++
Sbjct: 433 FFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVI 492
Query: 390 EYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFP 446
E+ + N+M+ ++AIV GP LL P+ E M Q+V +I + Q AD F P
Sbjct: 493 EHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELI--LQQCADIFPP 547
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 95.1 bits (235), Expect = 2e-19
Identities = 74/277 (26%), Positives = 141/277 (50%), Gaps = 17/277 (6%)
Query: 165 LSSSLQPAGAKAD-ALREEMEEAANRVEICRDQLSAD---MYSFVAKEIDYANYFQTLIE 220
LSS++ + D + EE+ ++ + +++ D + SF ID + +T
Sbjct: 570 LSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKT--- 626
Query: 221 VQAEYHRKSLTLLQAVLPQIKAQQE-AWVEKPSFGKPLEEHLTISGREIAFPIEACVTML 279
+K+L P ++A +E +++ FG L + ++ C+ +
Sbjct: 627 ------KKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHV 680
Query: 280 LECGMQEEGLFRVAPSASKLKKLKAALDCCV-VDVQEYS-ADPHAIAGALKSYLRELPEP 337
E G+ +G++RV+ + + ++KL+ A++ +D+ + D H I GALK + RELPEP
Sbjct: 681 EEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEP 740
Query: 338 LMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKM 397
L TF +++++ A QE +++ A+ + +LPK N + ++ L + L ++ E + N+M
Sbjct: 741 LFTFNHFNDFVNAIK-QEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRM 799
Query: 398 TPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGII 434
T ++AIV GP LL P+ E + T QIV +I
Sbjct: 800 TYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELI 836
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 94.7 bits (234), Expect = 3e-19
Identities = 91/371 (24%), Positives = 158/371 (42%), Gaps = 44/371 (11%)
Query: 272 IEACVTMLLECGMQEEGLFRVAPSASKLKKLKAAL-----------DCCVVDVQEYSADP 320
I C+ + G+ E+GL+R+ S+++KL + L D C +
Sbjct: 393 IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICA------EWEI 446
Query: 321 HAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRY 380
I ALK+YLR LP PLM ++ +I+A+ ++ Q+ ++ + + +LP+ N ++
Sbjct: 447 KTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQL 506
Query: 381 LIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQH 440
L+ L+ ++ N MT +N+ +V GP LL PQ E + +M IV IE +I++
Sbjct: 507 LMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEE-TVAAIMDIKFQNIV--IEILIEN 563
Query: 441 ADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMM 500
+ F + +T + +H++ + S P P + RPL++
Sbjct: 564 HEKIFNTVPDMPLT---NAQLHLSRKKSSDSKP-----------PSCSERPLTLFHTVQS 609
Query: 501 LEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPL 560
E ++ S+ + N + SS ++ + P + P + P P+P
Sbjct: 610 TEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLP-PNPS 668
Query: 561 PEQPLDSPAAPALS-------PSGLGLQPGPERTSTTKSKELSPGSAQKGSPGS-SQGTA 612
P PL SP+ P S S P T K+K L A+ S S + GT
Sbjct: 669 PTSPL-SPSWPMFSAPSSPMPTSSTSSDSSPVSTPFRKAKALYACKAEHDSELSFTAGTV 727
Query: 613 CAGTQPGAQPG 623
P +PG
Sbjct: 728 FDNVHPSQEPG 738
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 94.4 bits (233), Expect = 4e-19
Identities = 55/149 (36%), Positives = 83/149 (55%), Gaps = 2/149 (1%)
Query: 267 EIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSA--DPHAIA 324
++ + + CV + GM+E G++RV+ A+ ++ LKAA D DV + D +AIA
Sbjct: 1022 KVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIA 1081
Query: 325 GALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKF 384
G LK Y RELPEPL T E Y + + + + K + N LP+AN +L+
Sbjct: 1082 GTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDH 1141
Query: 385 LSKLSEYQDVNKMTPSNMAIVLGPNLLWP 413
L +++E + VNKM+ N+A V GP LL P
Sbjct: 1142 LKRVAEKEAVNKMSLHNLATVFGPTLLRP 1170
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 94.4 bits (233), Expect = 4e-19
Identities = 55/149 (36%), Positives = 83/149 (55%), Gaps = 2/149 (1%)
Query: 267 EIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSA--DPHAIA 324
++ + + CV + GM+E G++RV+ A+ ++ LKAA D DV + D +AIA
Sbjct: 1066 KVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIA 1125
Query: 325 GALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKF 384
G LK Y RELPEPL T E Y + + + + K + N LP+AN +L+
Sbjct: 1126 GTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDH 1185
Query: 385 LSKLSEYQDVNKMTPSNMAIVLGPNLLWP 413
L +++E + VNKM+ N+A V GP LL P
Sbjct: 1186 LKRVAEKEAVNKMSLHNLATVFGPTLLRP 1214
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,640,327
Number of Sequences: 37866
Number of extensions: 2235671
Number of successful extensions: 33227
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 507
Number of HSP's successfully gapped in prelim test: 2275
Number of HSP's that attempted gapping in prelim test: 14330
Number of HSP's gapped (non-prelim): 12258
length of query: 818
length of database: 18,247,518
effective HSP length: 111
effective length of query: 707
effective length of database: 14,044,392
effective search space: 9929385144
effective search space used: 9929385144
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.