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Search of human proteins with 151101140
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|151101140 coiled-coil domain containing 2 isoform a [Homo
sapiens]
(600 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|151101140 coiled-coil domain containing 2 isoform a [Homo sap... 1165 0.0
gi|151105223 coiled-coil domain containing 2 isoform a [Homo sap... 1165 0.0
gi|151105229 coiled-coil domain containing 2 isoform a [Homo sap... 1165 0.0
gi|151101151 coiled-coil domain containing 2 isoform b [Homo sap... 688 0.0
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 102 1e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 99 1e-20
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 99 1e-20
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 99 1e-20
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 99 1e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 99 1e-20
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 99 1e-20
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 99 1e-20
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 97 6e-20
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 91 3e-18
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 91 3e-18
gi|31982906 cingulin-like 1 [Homo sapiens] 90 7e-18
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 89 1e-17
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 89 1e-17
gi|38044112 restin isoform b [Homo sapiens] 89 2e-17
gi|4506751 restin isoform a [Homo sapiens] 89 2e-17
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 87 6e-17
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 86 7e-17
gi|71061468 centromere protein E [Homo sapiens] 85 2e-16
gi|7705415 hook homolog 1 [Homo sapiens] 84 3e-16
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 84 4e-16
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 83 8e-16
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 82 1e-15
gi|153791839 sodium channel associated protein 1 [Homo sapiens] 82 1e-15
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 82 1e-15
gi|112420968 coiled-coil domain containing 158 [Homo sapiens] 82 2e-15
>gi|151101140 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 1165 bits (3015), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV
Sbjct: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE
Sbjct: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
Sbjct: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
Query: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL
Sbjct: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
Query: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS
Sbjct: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
Query: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE 360
PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE
Sbjct: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE 360
Query: 361 LKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKM 420
LKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKM
Sbjct: 361 LKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKM 420
Query: 421 MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD 480
MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD
Sbjct: 421 MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD 480
Query: 481 LEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHS 540
LEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHS
Sbjct: 481 LEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHS 540
Query: 541 QLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN 600
QLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN
Sbjct: 541 QLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN 600
>gi|151105223 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 1165 bits (3015), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV
Sbjct: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE
Sbjct: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
Sbjct: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
Query: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL
Sbjct: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
Query: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS
Sbjct: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
Query: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE 360
PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE
Sbjct: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE 360
Query: 361 LKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKM 420
LKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKM
Sbjct: 361 LKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKM 420
Query: 421 MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD 480
MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD
Sbjct: 421 MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD 480
Query: 481 LEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHS 540
LEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHS
Sbjct: 481 LEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHS 540
Query: 541 QLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN 600
QLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN
Sbjct: 541 QLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN 600
>gi|151105229 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 1165 bits (3015), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV
Sbjct: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE
Sbjct: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
Sbjct: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
Query: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL
Sbjct: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
Query: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS
Sbjct: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
Query: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE 360
PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE
Sbjct: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE 360
Query: 361 LKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKM 420
LKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKM
Sbjct: 361 LKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKM 420
Query: 421 MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD 480
MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD
Sbjct: 421 MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD 480
Query: 481 LEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHS 540
LEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHS
Sbjct: 481 LEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHS 540
Query: 541 QLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN 600
QLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN
Sbjct: 541 QLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN 600
>gi|151101151 coiled-coil domain containing 2 isoform b [Homo
sapiens]
Length = 372
Score = 688 bits (1775), Expect = 0.0
Identities = 355/363 (97%), Positives = 357/363 (98%)
Query: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV
Sbjct: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE
Sbjct: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
Sbjct: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
Query: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL
Sbjct: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
Query: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS
Sbjct: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
Query: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE 360
PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ N +K
Sbjct: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKI 360
Query: 361 LKK 363
L+K
Sbjct: 361 LEK 363
Score = 54.7 bits (130), Expect = 2e-07
Identities = 62/289 (21%), Positives = 126/289 (43%), Gaps = 40/289 (13%)
Query: 201 IRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKES 260
+RS E+ E I+ + EN V YL + E L E+ LQ QL NM +
Sbjct: 101 LRSKISELTTEVNKLQKGIEMYNQENSV-YLSYEKRAETLAVEIKELQGQLADYNMLVDK 159
Query: 261 LEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIA 320
L ++ + E V+ + + ++ R E +S+ ER+ KQI+ +EI
Sbjct: 160 L-----NTNTEMEEVMNDYNMLKAQNDR-----ETQSLDVIFTERQAKEKQIRSVEEEI- 208
Query: 321 SMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKN 380
E+Q TD K F ++ KY E+K E + ++T ++ +
Sbjct: 209 EQEKQATDDIIKNMSFENQV----------------KYLEMKTTNEKLLQELDTLQQQLD 252
Query: 381 QELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQ 440
+ +K +EA I ++++Q + + +++L ++ + E + S +
Sbjct: 253 SQNMKKESLEAEIAH---------SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPME 303
Query: 441 NLTSDIQRLQLDLQKMELLESKMTEEQHSLK---SKIKQMTTDLEIYND 486
+++++ D Q++ +E ++T+ + + +I+Q+ DLE + D
Sbjct: 304 EREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 102 bits (253), Expect = 1e-21
Identities = 129/581 (22%), Positives = 255/581 (43%), Gaps = 68/581 (11%)
Query: 66 KVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQE 125
K A R Q L + + Q+++ + L + +K+ + ++L+ ++ Y ++
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 717
Query: 126 NSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKA-----QN 180
YLS E++ E L +IK+L+ + ++ + + + +N L+A Q
Sbjct: 718 ---YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774
Query: 181 DRETQSLDVIFTERQAKEKQIRSVEEEI---EQEKQATDDIIKNMSFENQVKYLEMKTTN 237
+ E + + + Q K + + S+++++ E+EKQ + +S E ++++
Sbjct: 775 EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH------- 827
Query: 238 EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKS 297
E+L + T +L M+KE+L E+ S VK + + + L +S ++ E++
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTEL--STVKDKLSKVSDSLKNSKSEFEK---ENQK 882
Query: 298 IGSPMEEREKLLKQIKDDNQEIASMERQLTDTKE---KINQFIEEIRQLDMDLEEHQGEM 354
+ + + EK K++K Q ME L + KE + + E QL ++L Q ++
Sbjct: 883 GKAAILDLEKTCKELKHQLQ--VQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940
Query: 355 NQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANI----VALLEHCSRNINRIEQI 410
Q LK+ E+ E K ++K QIEA +A+L+ N+++Q
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE-NKLQQQ 999
Query: 411 SSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDL----QKMELLESKMTEE 466
+ QEL ++ ++ +KSQ T + L SD + +L Q ++ +E K++
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
Query: 467 QHSLKSKIKQMTTDLEIYNDLPALKSSGEE---KIKKLHQERMILSTHRNAFKKIMEKQN 523
Q L S Q+ ++ +L K++ E+ K ++ QER K + EK+
Sbjct: 1060 QEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1119
Query: 524 I-------EYEALK-------TQLQEN------ETHSQLTNLERKWQHLEQNNFAMKE-- 561
+ E E +K T+L E E+ ++TNL+ Q L Q ++
Sbjct: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
Query: 562 ---FIATKSQESDYQPIKKNVTKQIAEYNKTIVD---ALHS 596
A + ++ + Q +K V K+ E K ++ LHS
Sbjct: 1180 DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS 1220
Score = 80.9 bits (198), Expect = 3e-15
Identities = 110/571 (19%), Positives = 236/571 (41%), Gaps = 72/571 (12%)
Query: 85 KGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIK 144
KGPQ ++ L L+S ++ELT + L + + Q+ Y E++ +V K
Sbjct: 278 KGPQ-EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD---YTKLEEKHNEESVSKK 333
Query: 145 ELQGQLADYNMLVDKLNTNTEMEEV-MNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRS 203
+Q L ++ +L + E ++ ++ ++ TQ L +E + K + +++
Sbjct: 334 NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
Query: 204 VEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEA 263
++++Q+++ + + E + ++ T +L + L++Q + K E
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 264 EIAHSQVKQEAV-------------LLHEKLYELESHRDQMIAEDKSIGSPMEER---EK 307
++A Q+K + L H+ + H++Q + + E + E+
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513
Query: 308 LLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGE---MNQKYKELKKR 364
+L+QI D +Q+I ++E L +KE I+ +E L ++ +GE +NQ ++
Sbjct: 514 VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTL 573
Query: 365 EEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRI--------EQISSITNQ 416
+E + E + + + + + H +R+ E S +
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 417 ELKMMQDDLNFKS----------------TEVQKSQSTAQNLTSDIQR------LQLDLQ 454
+ K+ Q D+ K+ ++Q TAQN D Q+ QLD
Sbjct: 634 KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693
Query: 455 KMEL---------LESKMTEEQHSLKSKIKQMTTDLE-----IYNDLPALKSSGEEKIKK 500
+L LES + E + S ++Q T +LE + D +K+S E+ ++
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLS-LEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
Query: 501 LHQERMILSTHRNAFKKIMEKQNIEYEAL-KTQLQENETHSQLTNLERKWQHLEQNNFAM 559
L Q+R + + ++ ++ +E E + T+L + L ++++K E+ +
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812
Query: 560 KEFIATKSQES--DYQPIKKNVTKQIAEYNK 588
K+ T SQE+ ++ + + + E K
Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQK 843
Score = 71.2 bits (173), Expect = 2e-12
Identities = 92/507 (18%), Positives = 222/507 (43%), Gaps = 38/507 (7%)
Query: 107 ELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN--- 163
EL E+ K Q + + + + ++L +++E Q + + + D
Sbjct: 108 ELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ 167
Query: 164 --TEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATD-DIIK 220
TE+ ++ + Y+ ++ + Q + + E + I+ ++ E+ Q D ++K
Sbjct: 168 LATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLK 227
Query: 221 NMSFENQVKY----LEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVL 276
+ Q LE + +EKL E LQ Q S L +E+A QE +
Sbjct: 228 KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKG--PQEVAV 285
Query: 277 LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDT------- 329
++L +L+S +++ +++++ + ++E+ ++++ + E + ++ + T
Sbjct: 286 YVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLD 345
Query: 330 ----KEKINQFIEEIRQLDMDLEEHQGEMNQKYK----ELKKREEHMDTFIETFEETKNQ 381
+ +++ + ++ ++L E +GE QK K E++ + +H+ + ++ + +
Sbjct: 346 CQQLQSRLSASETSLHRIHVELSE-KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE 404
Query: 382 ELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQN 441
+ + Q+++ I L ++ + ++ ++ + L K +V Q
Sbjct: 405 KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464
Query: 442 LTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD--LEIYNDL-PALKSSGEEKI 498
L ++ + +++ K T++QH + ++Q TT E NDL L+ G++
Sbjct: 465 LEEQLKEKVTNSTELQHQLDK-TKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523
Query: 499 KKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFA 558
K + E ++ + N ++EK+ + A K Q E ET + L L+ K L++
Sbjct: 524 KIQNLEALLQKSKENI--SLLEKEREDLYA-KIQAGEGET-AVLNQLQEKNHTLQEQVTQ 579
Query: 559 MKEFIATKSQESDYQPIKKNVTKQIAE 585
+ E + K+Q ++ ++N+ Q+ E
Sbjct: 580 LTEKL--KNQSESHKQAQENLHDQVQE 604
Score = 50.4 bits (119), Expect = 5e-06
Identities = 56/315 (17%), Positives = 133/315 (42%), Gaps = 36/315 (11%)
Query: 271 KQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQ-------IKDDNQEIASME 323
+ + LL +++ +L++ + + + +E+ + L +Q + D + E+ S+E
Sbjct: 82 RDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLE 141
Query: 324 RQLTDTKEK---INQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKN 380
+QL + + + I Q + Q L ++ KY E + E + + E N
Sbjct: 142 QQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELN 201
Query: 381 QELKRKAQIEANIVAL--LEHCSRNINRIEQISSIT-NQELKMMQDDLNFKSTEVQKSQS 437
+E ++ ++ +E + + Q+ ++ N L+ ++ K E +K QS
Sbjct: 202 KEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD-ECKKLQS 260
Query: 438 TAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEK 497
+ + I +L+ +L K + +E LKS + ++T + + K K
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
Query: 498 IKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENET------------------- 538
+++ H E S + + + +++++ + L+++L +ET
Sbjct: 321 LEEKHNEE---SVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
Query: 539 HSQLTNLERKWQHLE 553
+L+ +E K+QHL+
Sbjct: 378 KEELSEVETKYQHLK 392
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 99.0 bits (245), Expect = 1e-20
Identities = 123/523 (23%), Positives = 229/523 (43%), Gaps = 61/523 (11%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
KI EL ++ LQ+ ++ E + EK+ L E++ L+ +L D +D T
Sbjct: 1112 KIRELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELED---TLDSTATQ 1165
Query: 164 TEMEEVMN-DYNMLKAQNDRETQSLDVIFTERQAKEKQ-IRSVEEEIEQEKQATDDIIKN 221
E+ + +LK D ET+S + E + K Q + + E++EQ K+A ++ KN
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK-----QEAVL 276
++ N L EL L Q KK+ LEA++ Q K +
Sbjct: 1226 KQ--------TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 277 LHEKLYELESHRDQMI-----AEDK---------SIGSPMEEREKLLKQIKDDNQEIASM 322
L++K+++L++ + + AE K S+ S +++ ++LL++ +++
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQE 382
RQL + + + ++E + +LE H +N + + KK+ + + +E EE K +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 383 LKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNL 442
K +IE N+ E + +++E+ + QEL DDL ++ + NL
Sbjct: 1398 QK---EIE-NLTQQYEEKAAAYDKLEKTKNRLQQEL----DDL---VVDLDNQRQLVSNL 1446
Query: 443 TSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD-LEIYNDLPALKSSGEE----- 496
++ L + + + SK +E+ +++ ++ T L + L + EE
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506
Query: 497 KIKKLHQERMILS---THRNAFKKIMEKQNIE--YEALKTQLQENETHSQLTNLERKWQH 551
K+ K E ++ S +N + K+ +E E +KTQL+E E Q T E
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT--EDAKLR 1564
Query: 552 LEQNNFAMKEFIATKSQESDYQPIKK--NVTKQIAEYNKTIVD 592
LE N A+K Q D Q +K + +Q+ EY + D
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Score = 80.5 bits (197), Expect = 4e-15
Identities = 112/556 (20%), Positives = 241/556 (43%), Gaps = 82/556 (14%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
QQ LT MK + + +++ L +K+ L +V + ++ ++ E +
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL-QVTRQEEEMQAKEDELQKTKERQ 868
Query: 134 KRAETLAVEIKELQGQLADY-NMLVDKLNTNTEM------------------EEVMNDYN 174
++AE E+++ QL + N+L ++L TE+ EE++++
Sbjct: 869 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME 928
Query: 175 M-LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-IKNMSFENQVKYLE 232
L+ + DR Q + ER+ +Q+ +EE++E+E+ A + ++ ++ E ++K LE
Sbjct: 929 ARLEEEEDRGQQ----LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 984
Query: 233 -----MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESH 287
M N KL +E L++++ L +A + K + L +L++
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISD-------LTTNLAEEEEKAK------NLTKLKNK 1031
Query: 288 RDQMIAED----KSIGSPMEEREKLLKQIKDD----NQEIASMERQLTDTKEKINQFIEE 339
+ MI+E K +E EKL ++++ D +++IA ++ Q+ + K ++ + EE
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 340 IRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEE---TKNQELKRKAQIEANIVAL 396
++ L++ + N K++++ E H+ E + +N+ K+K + + AL
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 397 LEHCSRNINRIEQISSITNQELKMMQD----------DLNFKSTEVQKSQSTAQNLTSDI 446
++ S+ T QEL+ ++ D +S E Q Q Q +
Sbjct: 1152 KTELEDTLD-----STATQQELRAKREQEVTVLKKALDEETRSHEAQ-VQEMRQKHAQAV 1205
Query: 447 QRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERM 506
+ L L++ + ++ + + + +L+ + + +L + L K E K KKL +
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV---LGQAKQEVEHKKKKLEAQVQ 1262
Query: 507 ILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATK 566
L + + ++ + N + L+ +++ L E K L K+ +
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVE--SVTGMLNEAEGKAIKL------AKDVASLS 1314
Query: 567 SQESDYQPIKKNVTKQ 582
SQ D Q + + T+Q
Sbjct: 1315 SQLQDTQELLQEETRQ 1330
Score = 80.5 bits (197), Expect = 4e-15
Identities = 128/588 (21%), Positives = 244/588 (41%), Gaps = 102/588 (17%)
Query: 90 QILDKSYYLGLLRSKISELTTEVNKLQKGIE----MYNQENSVYLSYEKRAETLAVEIKE 145
Q+ D L S + L + QK IE Y ++ + Y EK L E+ +
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 146 LQGQLADYNMLVDKLNTNTE-----MEEVMNDYNMLKAQNDR--------ETQSLDVI-- 190
L L + LV L + E N + + DR ET++L +
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 191 ----FTERQAKEKQIRSVEEEIEQEKQATDDIIKNM--------SFENQVKYLEMKTTNE 238
++ E+ + ++ E+E + DD+ KN+ + E Q++ EMKT E
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME--EMKTQLE 1549
Query: 239 KLLQELDT-----LQQQLDSQNMK---KESLEAEIAHSQVKQEAVL--LHEKLYELESHR 288
+L EL L+ +++ Q +K + L+A ++ K+ + LHE ELE R
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 289 DQMI----AEDKSIG----------SPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN 334
Q A+ K G S ++ RE+ +KQ++ ++ +R+L D + +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 335 QFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIV 394
+ ++ + + + ++ Q ++L E + + K + + A +
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERAR----KQADLEKEELAEELASSLSGRN 1725
Query: 395 ALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQ 454
AL + R RI Q+ +EL+ Q ++ S V+K+ A+ L++++ + Q
Sbjct: 1726 ALQDEKRRLEARIAQLE----EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 455 KMELLESKMTEEQHSLKSKIKQM--TTDLEIYNDLPALKS-------------------- 492
K E ++ + L+SK+ +M + + + AL++
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 493 -SGEEKIKKLHQERMILSTHR---NAFKKIMEKQNIEYEALKTQLQENETHSQLTN---- 544
S ++K KKL + + + R +K+ EK N + LK QL+E E SQ N
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Query: 545 -LERKWQHLEQNNFAM-KEFIATKSQ-----ESDYQPIKKNVTKQIAE 585
L+R+ ++N AM +E A KS+ E+ + P +++ +++ E
Sbjct: 1902 KLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 99.0 bits (245), Expect = 1e-20
Identities = 123/523 (23%), Positives = 229/523 (43%), Gaps = 61/523 (11%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
KI EL ++ LQ+ ++ E + EK+ L E++ L+ +L D +D T
Sbjct: 1119 KIRELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELED---TLDSTATQ 1172
Query: 164 TEMEEVMN-DYNMLKAQNDRETQSLDVIFTERQAKEKQ-IRSVEEEIEQEKQATDDIIKN 221
E+ + +LK D ET+S + E + K Q + + E++EQ K+A ++ KN
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK-----QEAVL 276
++ N L EL L Q KK+ LEA++ Q K +
Sbjct: 1233 KQ--------TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 277 LHEKLYELESHRDQMI-----AEDK---------SIGSPMEEREKLLKQIKDDNQEIASM 322
L++K+++L++ + + AE K S+ S +++ ++LL++ +++
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQE 382
RQL + + + ++E + +LE H +N + + KK+ + + +E EE K +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 383 LKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNL 442
K +IE N+ E + +++E+ + QEL DDL ++ + NL
Sbjct: 1405 QK---EIE-NLTQQYEEKAAAYDKLEKTKNRLQQEL----DDL---VVDLDNQRQLVSNL 1453
Query: 443 TSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD-LEIYNDLPALKSSGEE----- 496
++ L + + + SK +E+ +++ ++ T L + L + EE
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513
Query: 497 KIKKLHQERMILS---THRNAFKKIMEKQNIE--YEALKTQLQENETHSQLTNLERKWQH 551
K+ K E ++ S +N + K+ +E E +KTQL+E E Q T E
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT--EDAKLR 1571
Query: 552 LEQNNFAMKEFIATKSQESDYQPIKK--NVTKQIAEYNKTIVD 592
LE N A+K Q D Q +K + +Q+ EY + D
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Score = 80.5 bits (197), Expect = 4e-15
Identities = 112/556 (20%), Positives = 241/556 (43%), Gaps = 82/556 (14%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
QQ LT MK + + +++ L +K+ L +V + ++ ++ E +
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL-QVTRQEEEMQAKEDELQKTKERQ 875
Query: 134 KRAETLAVEIKELQGQLADY-NMLVDKLNTNTEM------------------EEVMNDYN 174
++AE E+++ QL + N+L ++L TE+ EE++++
Sbjct: 876 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME 935
Query: 175 M-LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-IKNMSFENQVKYLE 232
L+ + DR Q + ER+ +Q+ +EE++E+E+ A + ++ ++ E ++K LE
Sbjct: 936 ARLEEEEDRGQQ----LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 991
Query: 233 -----MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESH 287
M N KL +E L++++ L +A + K + L +L++
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISD-------LTTNLAEEEEKAK------NLTKLKNK 1038
Query: 288 RDQMIAED----KSIGSPMEEREKLLKQIKDD----NQEIASMERQLTDTKEKINQFIEE 339
+ MI+E K +E EKL ++++ D +++IA ++ Q+ + K ++ + EE
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 340 IRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEE---TKNQELKRKAQIEANIVAL 396
++ L++ + N K++++ E H+ E + +N+ K+K + + AL
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 397 LEHCSRNINRIEQISSITNQELKMMQD----------DLNFKSTEVQKSQSTAQNLTSDI 446
++ S+ T QEL+ ++ D +S E Q Q Q +
Sbjct: 1159 KTELEDTLD-----STATQQELRAKREQEVTVLKKALDEETRSHEAQ-VQEMRQKHAQAV 1212
Query: 447 QRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERM 506
+ L L++ + ++ + + + +L+ + + +L + L K E K KKL +
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV---LGQAKQEVEHKKKKLEAQVQ 1269
Query: 507 ILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATK 566
L + + ++ + N + L+ +++ L E K L K+ +
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVE--SVTGMLNEAEGKAIKL------AKDVASLS 1321
Query: 567 SQESDYQPIKKNVTKQ 582
SQ D Q + + T+Q
Sbjct: 1322 SQLQDTQELLQEETRQ 1337
Score = 80.5 bits (197), Expect = 4e-15
Identities = 128/588 (21%), Positives = 244/588 (41%), Gaps = 102/588 (17%)
Query: 90 QILDKSYYLGLLRSKISELTTEVNKLQKGIE----MYNQENSVYLSYEKRAETLAVEIKE 145
Q+ D L S + L + QK IE Y ++ + Y EK L E+ +
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 146 LQGQLADYNMLVDKLNTNTE-----MEEVMNDYNMLKAQNDR--------ETQSLDVI-- 190
L L + LV L + E N + + DR ET++L +
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 191 ----FTERQAKEKQIRSVEEEIEQEKQATDDIIKNM--------SFENQVKYLEMKTTNE 238
++ E+ + ++ E+E + DD+ KN+ + E Q++ EMKT E
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME--EMKTQLE 1556
Query: 239 KLLQELDT-----LQQQLDSQNMK---KESLEAEIAHSQVKQEAVL--LHEKLYELESHR 288
+L EL L+ +++ Q +K + L+A ++ K+ + LHE ELE R
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 289 DQMI----AEDKSIG----------SPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN 334
Q A+ K G S ++ RE+ +KQ++ ++ +R+L D + +
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 335 QFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIV 394
+ ++ + + + ++ Q ++L E + + K + + A +
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERAR----KQADLEKEELAEELASSLSGRN 1732
Query: 395 ALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQ 454
AL + R RI Q+ +EL+ Q ++ S V+K+ A+ L++++ + Q
Sbjct: 1733 ALQDEKRRLEARIAQLE----EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 455 KMELLESKMTEEQHSLKSKIKQM--TTDLEIYNDLPALKS-------------------- 492
K E ++ + L+SK+ +M + + + AL++
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 493 -SGEEKIKKLHQERMILSTHR---NAFKKIMEKQNIEYEALKTQLQENETHSQLTN---- 544
S ++K KKL + + + R +K+ EK N + LK QL+E E SQ N
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Query: 545 -LERKWQHLEQNNFAM-KEFIATKSQ-----ESDYQPIKKNVTKQIAE 585
L+R+ ++N AM +E A KS+ E+ + P +++ +++ E
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 99.0 bits (245), Expect = 1e-20
Identities = 123/523 (23%), Positives = 229/523 (43%), Gaps = 61/523 (11%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
KI EL ++ LQ+ ++ E + EK+ L E++ L+ +L D +D T
Sbjct: 1119 KIRELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELED---TLDSTATQ 1172
Query: 164 TEMEEVMN-DYNMLKAQNDRETQSLDVIFTERQAKEKQ-IRSVEEEIEQEKQATDDIIKN 221
E+ + +LK D ET+S + E + K Q + + E++EQ K+A ++ KN
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK-----QEAVL 276
++ N L EL L Q KK+ LEA++ Q K +
Sbjct: 1233 KQ--------TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 277 LHEKLYELESHRDQMI-----AEDK---------SIGSPMEEREKLLKQIKDDNQEIASM 322
L++K+++L++ + + AE K S+ S +++ ++LL++ +++
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQE 382
RQL + + + ++E + +LE H +N + + KK+ + + +E EE K +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 383 LKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNL 442
K +IE N+ E + +++E+ + QEL DDL ++ + NL
Sbjct: 1405 QK---EIE-NLTQQYEEKAAAYDKLEKTKNRLQQEL----DDL---VVDLDNQRQLVSNL 1453
Query: 443 TSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD-LEIYNDLPALKSSGEE----- 496
++ L + + + SK +E+ +++ ++ T L + L + EE
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513
Query: 497 KIKKLHQERMILS---THRNAFKKIMEKQNIE--YEALKTQLQENETHSQLTNLERKWQH 551
K+ K E ++ S +N + K+ +E E +KTQL+E E Q T E
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT--EDAKLR 1571
Query: 552 LEQNNFAMKEFIATKSQESDYQPIKK--NVTKQIAEYNKTIVD 592
LE N A+K Q D Q +K + +Q+ EY + D
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Score = 80.5 bits (197), Expect = 4e-15
Identities = 112/556 (20%), Positives = 241/556 (43%), Gaps = 82/556 (14%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
QQ LT MK + + +++ L +K+ L +V + ++ ++ E +
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL-QVTRQEEEMQAKEDELQKTKERQ 875
Query: 134 KRAETLAVEIKELQGQLADY-NMLVDKLNTNTEM------------------EEVMNDYN 174
++AE E+++ QL + N+L ++L TE+ EE++++
Sbjct: 876 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME 935
Query: 175 M-LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-IKNMSFENQVKYLE 232
L+ + DR Q + ER+ +Q+ +EE++E+E+ A + ++ ++ E ++K LE
Sbjct: 936 ARLEEEEDRGQQ----LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 991
Query: 233 -----MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESH 287
M N KL +E L++++ L +A + K + L +L++
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISD-------LTTNLAEEEEKAK------NLTKLKNK 1038
Query: 288 RDQMIAED----KSIGSPMEEREKLLKQIKDD----NQEIASMERQLTDTKEKINQFIEE 339
+ MI+E K +E EKL ++++ D +++IA ++ Q+ + K ++ + EE
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 340 IRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEE---TKNQELKRKAQIEANIVAL 396
++ L++ + N K++++ E H+ E + +N+ K+K + + AL
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 397 LEHCSRNINRIEQISSITNQELKMMQD----------DLNFKSTEVQKSQSTAQNLTSDI 446
++ S+ T QEL+ ++ D +S E Q Q Q +
Sbjct: 1159 KTELEDTLD-----STATQQELRAKREQEVTVLKKALDEETRSHEAQ-VQEMRQKHAQAV 1212
Query: 447 QRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERM 506
+ L L++ + ++ + + + +L+ + + +L + L K E K KKL +
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV---LGQAKQEVEHKKKKLEAQVQ 1269
Query: 507 ILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATK 566
L + + ++ + N + L+ +++ L E K L K+ +
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVE--SVTGMLNEAEGKAIKL------AKDVASLS 1321
Query: 567 SQESDYQPIKKNVTKQ 582
SQ D Q + + T+Q
Sbjct: 1322 SQLQDTQELLQEETRQ 1337
Score = 78.2 bits (191), Expect = 2e-14
Identities = 125/566 (22%), Positives = 233/566 (41%), Gaps = 97/566 (17%)
Query: 90 QILDKSYYLGLLRSKISELTTEVNKLQKGIE----MYNQENSVYLSYEKRAETLAVEIKE 145
Q+ D L S + L + QK IE Y ++ + Y EK L E+ +
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 146 LQGQLADYNMLVDKLNTNTE-----MEEVMNDYNMLKAQNDR--------ETQSLDVI-- 190
L L + LV L + E N + + DR ET++L +
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 191 ----FTERQAKEKQIRSVEEEIEQEKQATDDIIKNM--------SFENQVKYLEMKTTNE 238
++ E+ + ++ E+E + DD+ KN+ + E Q++ EMKT E
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME--EMKTQLE 1556
Query: 239 KLLQELDT-----LQQQLDSQNMK---KESLEAEIAHSQVKQEAVL--LHEKLYELESHR 288
+L EL L+ +++ Q +K + L+A ++ K+ + LHE ELE R
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 289 DQMI----AEDKSIG----------SPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN 334
Q A+ K G S ++ RE+ +KQ++ ++ +R+L D + +
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 335 QFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIV 394
+ ++ + + + ++ Q ++L E + + K + + A +
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERAR----KQADLEKEELAEELASSLSGRN 1732
Query: 395 ALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQ 454
AL + R RI Q+ +EL+ Q ++ S V+K+ A+ L++++ + Q
Sbjct: 1733 ALQDEKRRLEARIAQLE----EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 455 KMELLESKMTEEQHSLKSKIKQM--TTDLEIYNDLPALKS-------------------- 492
K E ++ + L+SK+ +M + + + AL++
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 493 -SGEEKIKKLHQERMILSTHR---NAFKKIMEKQNIEYEALKTQLQENETHSQLTN---- 544
S ++K KKL + + + R +K+ EK N + LK QL+E E SQ N
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Query: 545 -LERKWQHLEQNNFAM-KEFIATKSQ 568
L+R+ ++N AM +E A KS+
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSK 1934
Score = 65.1 bits (157), Expect = 2e-10
Identities = 75/395 (18%), Positives = 176/395 (44%), Gaps = 29/395 (7%)
Query: 101 LRSKISEL-----TTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNM 155
+++++ EL TE KL+ + M + + R E + ++LQ QL +Y
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 156 LVDKLNTNTEM-----EEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQ 210
++ + +++ D L+ Q D + + + + + Q++ + E+E
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 211 EKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQV 270
+ + D+I EN+ K ++ +L ++L ++ +++KE L E+A S
Sbjct: 1671 ARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 271 KQEAVLLHEKLYELE-SHRDQMIAEDKSIGSPMEER-EKLLKQIKDDNQEIASMERQLTD 328
+ A+ ++ E + ++ + E++ M +R K +Q + + E+A+ ER
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQ 1788
Query: 329 TKEKINQFIE-EIRQLDMDLEEHQGEMNQKYKE----LKKREEHMDTFIETFEETKN--- 380
E Q +E + ++L L E +G + K+K L+ + ++ +E K
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 381 QELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQ 440
+ LK+K + I+ +E + + ++ + N +K ++ L ++++ +Q
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-------EEAEEESQ 1901
Query: 441 NLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIK 475
+ ++ ++LQ +L + M E ++LKSK++
Sbjct: 1902 RINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 99.0 bits (245), Expect = 1e-20
Identities = 123/523 (23%), Positives = 229/523 (43%), Gaps = 61/523 (11%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
KI EL ++ LQ+ ++ E + EK+ L E++ L+ +L D +D T
Sbjct: 1112 KIRELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELED---TLDSTATQ 1165
Query: 164 TEMEEVMN-DYNMLKAQNDRETQSLDVIFTERQAKEKQ-IRSVEEEIEQEKQATDDIIKN 221
E+ + +LK D ET+S + E + K Q + + E++EQ K+A ++ KN
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK-----QEAVL 276
++ N L EL L Q KK+ LEA++ Q K +
Sbjct: 1226 KQ--------TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 277 LHEKLYELESHRDQMI-----AEDK---------SIGSPMEEREKLLKQIKDDNQEIASM 322
L++K+++L++ + + AE K S+ S +++ ++LL++ +++
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQE 382
RQL + + + ++E + +LE H +N + + KK+ + + +E EE K +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 383 LKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNL 442
K +IE N+ E + +++E+ + QEL DDL ++ + NL
Sbjct: 1398 QK---EIE-NLTQQYEEKAAAYDKLEKTKNRLQQEL----DDL---VVDLDNQRQLVSNL 1446
Query: 443 TSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD-LEIYNDLPALKSSGEE----- 496
++ L + + + SK +E+ +++ ++ T L + L + EE
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506
Query: 497 KIKKLHQERMILS---THRNAFKKIMEKQNIE--YEALKTQLQENETHSQLTNLERKWQH 551
K+ K E ++ S +N + K+ +E E +KTQL+E E Q T E
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT--EDAKLR 1564
Query: 552 LEQNNFAMKEFIATKSQESDYQPIKK--NVTKQIAEYNKTIVD 592
LE N A+K Q D Q +K + +Q+ EY + D
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Score = 80.5 bits (197), Expect = 4e-15
Identities = 112/556 (20%), Positives = 241/556 (43%), Gaps = 82/556 (14%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
QQ LT MK + + +++ L +K+ L +V + ++ ++ E +
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL-QVTRQEEEMQAKEDELQKTKERQ 868
Query: 134 KRAETLAVEIKELQGQLADY-NMLVDKLNTNTEM------------------EEVMNDYN 174
++AE E+++ QL + N+L ++L TE+ EE++++
Sbjct: 869 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME 928
Query: 175 M-LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-IKNMSFENQVKYLE 232
L+ + DR Q + ER+ +Q+ +EE++E+E+ A + ++ ++ E ++K LE
Sbjct: 929 ARLEEEEDRGQQ----LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 984
Query: 233 -----MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESH 287
M N KL +E L++++ L +A + K + L +L++
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISD-------LTTNLAEEEEKAK------NLTKLKNK 1031
Query: 288 RDQMIAED----KSIGSPMEEREKLLKQIKDD----NQEIASMERQLTDTKEKINQFIEE 339
+ MI+E K +E EKL ++++ D +++IA ++ Q+ + K ++ + EE
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 340 IRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEE---TKNQELKRKAQIEANIVAL 396
++ L++ + N K++++ E H+ E + +N+ K+K + + AL
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 397 LEHCSRNINRIEQISSITNQELKMMQD----------DLNFKSTEVQKSQSTAQNLTSDI 446
++ S+ T QEL+ ++ D +S E Q Q Q +
Sbjct: 1152 KTELEDTLD-----STATQQELRAKREQEVTVLKKALDEETRSHEAQ-VQEMRQKHAQAV 1205
Query: 447 QRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERM 506
+ L L++ + ++ + + + +L+ + + +L + L K E K KKL +
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV---LGQAKQEVEHKKKKLEAQVQ 1262
Query: 507 ILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATK 566
L + + ++ + N + L+ +++ L E K L K+ +
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVE--SVTGMLNEAEGKAIKL------AKDVASLS 1314
Query: 567 SQESDYQPIKKNVTKQ 582
SQ D Q + + T+Q
Sbjct: 1315 SQLQDTQELLQEETRQ 1330
Score = 78.2 bits (191), Expect = 2e-14
Identities = 125/566 (22%), Positives = 233/566 (41%), Gaps = 97/566 (17%)
Query: 90 QILDKSYYLGLLRSKISELTTEVNKLQKGIE----MYNQENSVYLSYEKRAETLAVEIKE 145
Q+ D L S + L + QK IE Y ++ + Y EK L E+ +
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 146 LQGQLADYNMLVDKLNTNTE-----MEEVMNDYNMLKAQNDR--------ETQSLDVI-- 190
L L + LV L + E N + + DR ET++L +
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 191 ----FTERQAKEKQIRSVEEEIEQEKQATDDIIKNM--------SFENQVKYLEMKTTNE 238
++ E+ + ++ E+E + DD+ KN+ + E Q++ EMKT E
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME--EMKTQLE 1549
Query: 239 KLLQELDT-----LQQQLDSQNMK---KESLEAEIAHSQVKQEAVL--LHEKLYELESHR 288
+L EL L+ +++ Q +K + L+A ++ K+ + LHE ELE R
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 289 DQMI----AEDKSIG----------SPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN 334
Q A+ K G S ++ RE+ +KQ++ ++ +R+L D + +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 335 QFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIV 394
+ ++ + + + ++ Q ++L E + + K + + A +
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERAR----KQADLEKEELAEELASSLSGRN 1725
Query: 395 ALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQ 454
AL + R RI Q+ +EL+ Q ++ S V+K+ A+ L++++ + Q
Sbjct: 1726 ALQDEKRRLEARIAQLE----EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 455 KMELLESKMTEEQHSLKSKIKQM--TTDLEIYNDLPALKS-------------------- 492
K E ++ + L+SK+ +M + + + AL++
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 493 -SGEEKIKKLHQERMILSTHR---NAFKKIMEKQNIEYEALKTQLQENETHSQLTN---- 544
S ++K KKL + + + R +K+ EK N + LK QL+E E SQ N
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Query: 545 -LERKWQHLEQNNFAM-KEFIATKSQ 568
L+R+ ++N AM +E A KS+
Sbjct: 1902 KLQRELDEATESNEAMGREVNALKSK 1927
Score = 65.1 bits (157), Expect = 2e-10
Identities = 75/395 (18%), Positives = 176/395 (44%), Gaps = 29/395 (7%)
Query: 101 LRSKISEL-----TTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNM 155
+++++ EL TE KL+ + M + + R E + ++LQ QL +Y
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 156 LVDKLNTNTEM-----EEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQ 210
++ + +++ D L+ Q D + + + + + Q++ + E+E
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 211 EKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQV 270
+ + D+I EN+ K ++ +L ++L ++ +++KE L E+A S
Sbjct: 1664 ARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 271 KQEAVLLHEKLYELE-SHRDQMIAEDKSIGSPMEER-EKLLKQIKDDNQEIASMERQLTD 328
+ A+ ++ E + ++ + E++ M +R K +Q + + E+A+ ER
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQ 1781
Query: 329 TKEKINQFIE-EIRQLDMDLEEHQGEMNQKYKE----LKKREEHMDTFIETFEETKN--- 380
E Q +E + ++L L E +G + K+K L+ + ++ +E K
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 381 QELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQ 440
+ LK+K + I+ +E + + ++ + N +K ++ L ++++ +Q
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-------EEAEEESQ 1894
Query: 441 NLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIK 475
+ ++ ++LQ +L + M E ++LKSK++
Sbjct: 1895 RINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 98.6 bits (244), Expect = 1e-20
Identities = 106/443 (23%), Positives = 198/443 (44%), Gaps = 50/443 (11%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT 192
E +A +LA ++E Q A+ L + T EME++M+ D +S+ +
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFRT--EMEDLMSS-------KDDVGKSVHELEK 1525
Query: 193 ERQAKEKQIRSVE---EEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQ 249
++A E+Q+ ++ EE+E E QAT+D + +V MK E+ LQ D +
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRL----EVNLQAMKAQFERDLQGRDEQSE 1581
Query: 250 QLDSQNMKK-ESLEAEIAHSQVKQEAVLLHEK-----LYELESHRDQMIAEDKSIGSPME 303
+ Q +++ +EAE+ + ++ + K L +LE+H D S +
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID----------SANK 1631
Query: 304 EREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKEL-- 361
R++ +KQ++ ++ R+L DT+ + + + ++ + L+ + EM Q +EL
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691
Query: 362 -----KKREEHMDTFIETFEETKNQ---ELKRKAQIEANIVAL---LEHCSRNINRIEQI 410
++ ++ D + + + L+ K ++EA I L LE N I
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751
Query: 411 SSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKME-LLESKMTEEQHS 469
N ++ + DLN + + QK+++ Q L + L++ LQ+ME ++SK +
Sbjct: 1752 LKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITA 1811
Query: 470 LKSKIKQMTTDL--EIYNDLPALKSSGEEKIKKLHQERMILSTHRNA--FKKIMEKQNIE 525
L++KI Q+ L E A K + K + RNA +K +K +
Sbjct: 1812 LEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTR 1871
Query: 526 YEALKTQLQENETHSQLTNLERK 548
+ LK QL+E E +Q N R+
Sbjct: 1872 LKQLKRQLEEAEEEAQRANASRR 1894
Score = 89.4 bits (220), Expect = 9e-18
Identities = 110/518 (21%), Positives = 233/518 (44%), Gaps = 51/518 (9%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
KI EL +++++LQ+ +E E + EK+ L E++ L+ +L D L++
Sbjct: 1105 KIRELESQISELQEDLE---SERASRNKAEKQKRDLGEELEALKTELED------TLDST 1155
Query: 164 TEMEEVMN----DYNMLKAQNDRETQSLDVIFTERQAKEKQ-IRSVEEEIEQEKQATDDI 218
+E+ + + N+LK + E ++ + E + K Q + + E++EQ K+ ++
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 219 IKNMS--------FENQVKYL-EMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQ 269
K N+VK L + K +E ++++ Q+L + + E + E+A
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 270 VKQEAVL--LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLT 327
K + L + L + +S ++ + ++ S +++ ++LL++ +++ +Q+
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335
Query: 328 DTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKA 387
D K + +EE + +LE+ ++ + ++KK+ E +ET EE K
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKR------- 1388
Query: 388 QIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQ 447
+++ ++ L + + +++ T L+ DDL ++ + +A NL +
Sbjct: 1389 KLQKDLEGLSQRHEEKVAAYDKLEK-TKTRLQQELDDL---LVDLDHQRQSACNLEKKQK 1444
Query: 448 RLQLDLQKMELLESKMTEEQHSLKSKIKQMTTD-LEIYNDL-PALKSSGE-EKIKKLHQE 504
+ L + + + +K EE+ +++ ++ T L + L A++ E E++ K +
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRT 1504
Query: 505 RM--ILSTHRNAFKKIMEKQNI------EYEALKTQLQENETHSQLTNLERKWQHLEQNN 556
M ++S+ + K + E + + E +KTQL+E E Q T E LE N
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT--EDAKLRLEVNL 1562
Query: 557 FAMKEFIATKSQESDYQ--PIKKNVTKQIAEYNKTIVD 592
AMK Q D Q KK + +Q+ E + D
Sbjct: 1563 QAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Score = 85.5 bits (210), Expect = 1e-16
Identities = 127/605 (20%), Positives = 250/605 (41%), Gaps = 125/605 (20%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
QQ LT MK + + +++ L +K+ L +V++ ++ EM +E + E
Sbjct: 803 QQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLL-QVSRQEE--EMMAKEEELVKVRE 859
Query: 134 KR--AETLAVEIKELQGQL-ADYNMLVDKLNTNTEM------------------EEVMND 172
K+ AE E++ LQ QL A+ L ++L TE+ EE+ +D
Sbjct: 860 KQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHD 919
Query: 173 YNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLE 232
L+A+ + E + + E++ ++ I+ +EE++E+E+ A Q LE
Sbjct: 920 ---LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA-----------RQKLQLE 965
Query: 233 MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMI 292
K T E L++L+ Q L+ QN K + +E LL +++ E ++ +
Sbjct: 966 -KVTTEAKLKKLEEEQIILEDQNCK------------LAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 293 AEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQG 352
+ KS+ + E ++ +++ + ++L T+ K+ + L + E Q
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG---DSTDLSDQIAELQA 1069
Query: 353 EMNQKYKELKKREEHMDTFIETFEET---KNQELKRKAQIEANIVAL---LEHCSRNINR 406
++ + +L K+EE + + EE KN LK+ ++E+ I L LE + N+
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNK 1129
Query: 407 IEQISSITNQELKMMQDDL-----------NFKSTEVQKSQSTAQNLTSDIQRLQLDLQK 455
E+ +EL+ ++ +L +S Q+ + L + + + +Q+
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQE 1189
Query: 456 MELLESKMTEEQHSLKSKIKQMTTDL------------EIYNDLPAL---KSSGEEKIKK 500
M S+ EE + K++ +L E+ N++ L K E K KK
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 501 LHQERMILSTHRNAFKKI------------MEKQNI----------------EYEALKTQ 532
+ + L N +++ +E N+ ++ AL++Q
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309
Query: 533 LQE-----NETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYN 587
LQ+ E + Q +L K + +E + +E Q + + K N+ KQIA +
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE------QLEEEEEAKHNLEKQIATLH 1363
Query: 588 KTIVD 592
+ D
Sbjct: 1364 AQVAD 1368
Score = 68.9 bits (167), Expect = 1e-11
Identities = 69/359 (19%), Positives = 162/359 (45%), Gaps = 31/359 (8%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT 192
E++ + L +++E++ +L D + +++ D L+A D ++ D
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERK--QRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK 1638
Query: 193 ERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLD 252
+ + + Q++ E++ + + ++I+ EN+ K M+ +L +EL ++
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAK-ENEKKLKSMEAEMIQLQEELAAAERAKR 1697
Query: 253 SQNMKKESLEAEIAHSQVK-----QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREK 307
+++ L EIA+S K +E L ++ +LE ++ + I +++
Sbjct: 1698 QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL 1757
Query: 308 LLKQIKDDNQEIASMERQLTDTKEKINQFIE-EIRQLDMDLEEHQGEMNQKYK------- 359
+ QI D ++ER E Q +E + ++L + L+E +G + KYK
Sbjct: 1758 QIDQINTD----LNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALE 1813
Query: 360 -ELKKREEHMDTFIETFE-ETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQE 417
++ + EE +D ET E + ++++R + +++ ++ RN + + + +
Sbjct: 1814 AKIAQLEEQLDN--ETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTR 1871
Query: 418 LKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQ 476
LK ++ L ++++ AQ + ++LQ +L+ M E SLK+K+++
Sbjct: 1872 LKQLKRQL-------EEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 98.6 bits (244), Expect = 1e-20
Identities = 113/516 (21%), Positives = 245/516 (47%), Gaps = 49/516 (9%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVE--IKE 145
Q+Q+ ++ + L + K + T +++ LQ+ I++Y E + + E E I+E
Sbjct: 274 QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEE 333
Query: 146 LQGQLADYNM----LVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT-----ERQA 196
L ++ + L DKL T ++++ + Q ++E +++ + T ERQ+
Sbjct: 334 LNTKIIEEEKKTLELKDKLTT---ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQS 390
Query: 197 KE--KQIRSVEEEIEQ----EKQATDDIIKNMSFENQVKYLEMKTTNEKLL-QELDTLQQ 249
E KQ+ EE+++ + Q DI++ M E Q K +++ +++ Q++ ++Q
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE----R 305
+L Q+M + E + H + A+ + + E M + +++ +
Sbjct: 451 ELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKRE 365
EKL +++ +E +++RQL D E+++ E+I++ + E + ++N+ +K L E
Sbjct: 510 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569
Query: 366 EHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRI-EQISSITNQELKMMQDD 424
+ + E K ELK +A++ N LE + N + ++++ EL+ ++
Sbjct: 570 DLKAEIVSASESRKELELKHEAEV-TNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ 628
Query: 425 LNFK-STEVQKSQSTAQ-NLTSDIQRLQLDL-----QKMELLESKMTE-------EQHSL 470
L F E+ K + + +I++L+ +L Q+++ L+++M++ E+ +L
Sbjct: 629 LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL 688
Query: 471 KSKIKQMTTDLEIYNDL--PALKSSGEE---KIKKLHQERMILSTHRNAFKKIMEKQNIE 525
+K Q+ ++ DL + S EE +I +L +E IL +K +Q ++
Sbjct: 689 ITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK--EKGTLEQEVQ 746
Query: 526 YEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKE 561
LKT+L E + + +L+ K+ LE N +K+
Sbjct: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD 782
Score = 75.1 bits (183), Expect = 2e-13
Identities = 115/523 (21%), Positives = 221/523 (42%), Gaps = 84/523 (16%)
Query: 94 KSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADY 153
K L+ SK E+T ++N+LQK IE+ QE EK TL E++ELQ +
Sbjct: 703 KDLQQSLVNSKSEEMTLQINELQKEIEILRQE-------EKEKGTLEQEVQELQLKTE-- 753
Query: 154 NMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQ 213
L++K +M+E ND AQ + E ++ E++ E ++ ++E+
Sbjct: 754 --LLEK-----QMKEKENDLQEKFAQLEAENS---ILKDEKKTLEDMLKIHTPVSQEERL 803
Query: 214 ATDDIIKNMS----FENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEA--EIAH 267
D IK+ S +E +++ L + NE L Q+ L ++++ Q E E+ +
Sbjct: 804 IFLDSIKSKSKDSVWEKEIEILIEE--NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
Query: 268 SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEER----------EKLLKQIKDDNQ 317
++++E L + +LE +++ E KS + E K+ + D+++
Sbjct: 862 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921
Query: 318 EIAS--------MERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMD 369
+ +E+ T+ EK+ E +L L + ++ QK+ E+ E
Sbjct: 922 TFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEE-- 979
Query: 370 TFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKS 429
+++ ++ K Q R ++E I N NR E + S Q ++ + S
Sbjct: 980 --VKSLKQEKEQVSLRCRELEIII---------NHNRAENVQSCDTQVSSLLDGVVTMTS 1028
Query: 430 TEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSL--KSKIKQMTTD-LEIYND 486
+ S S + ++ ++E K++ E ++ +SK +Q+ D L
Sbjct: 1029 RGAEGSVSKVNKSFGEESKI--------MVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080
Query: 487 LPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKT-------QLQENETH 539
+L+++ + KL +E +L + +N + ME Q I + + + ENE
Sbjct: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
Query: 540 SQLTNLERKWQHLEQNNFAMKEFI--ATKSQESDYQPIKKNVT 580
L +L+ E+ FA +E I K + + Q +K T
Sbjct: 1141 KALCSLK------EELIFAQEEKIKELQKIHQLELQTMKTQET 1177
Score = 70.9 bits (172), Expect = 3e-12
Identities = 108/524 (20%), Positives = 215/524 (41%), Gaps = 100/524 (19%)
Query: 130 LSYEKRA-ETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLD 188
L E RA E LAVE+ + +G + Y ++ + + Q +T +D
Sbjct: 1903 LHEESRAREQLAVELSKAEGVIDGY----------------ADEKTLFERQIQEKTDIID 1946
Query: 189 VIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTL- 247
+ E ++ +E+E E+Q + + +S + + E ++LLQE + L
Sbjct: 1947 RLEQELLCASNRL----QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
Query: 248 QQQLDSQ--------NMKKESLEAEI-AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSI 298
+++L+ Q +++K+ EI QV + L EK EL R Q A +K +
Sbjct: 2003 KEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQL 2062
Query: 299 GSP------------------MEEREKLLKQIK----------DDNQEIASMERQLTDTK 330
+E +KL +Q+K +E+ + L +
Sbjct: 2063 EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT 2122
Query: 331 EKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQ------ELK 384
+K ++ + QL D++E E+ + +++ E+ + +TF++ +++ E K
Sbjct: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK 2182
Query: 385 RKAQIEANIVA---LLEHCSRNINRIEQISSITNQELKMMQDDLN--FKSTEVQKSQSTA 439
+ +E + A ++ + I +E+ +EL+ +++ E+QK +ST
Sbjct: 2183 PELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2242
Query: 440 --QNLTSDIQRLQLDLQKMELL----ESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSS 493
Q L + + + D++K+ L ++ T++QH L K Q+ + E+ D
Sbjct: 2243 RLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEID------Q 2296
Query: 494 GEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQ------------ENETHSQ 541
E++ KL Q+ I + + K++E++N L+TQ++ E Q
Sbjct: 2297 LNEQVTKLQQQLKITTDN-----KVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2351
Query: 542 LTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAE 585
L + K Q E N K + S + +K + IAE
Sbjct: 2352 LNEVIEKLQQ-ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE 2394
Score = 70.9 bits (172), Expect = 3e-12
Identities = 109/522 (20%), Positives = 233/522 (44%), Gaps = 70/522 (13%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLA----VEIKELQGQLADYNMLVD 158
S + +L T++ +LQ+ E+Y+ S + R E L V ++E LA + +
Sbjct: 2992 SSLKDLITKM-QLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3050
Query: 159 KLNTNTEMEEVMNDYNMLKAQNDRETQSL---------DVIFTERQAKEKQIR----SVE 205
L T T+ ++N + E Q+ + +E QA Q+ +++
Sbjct: 3051 ALGT-TDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLK 3109
Query: 206 EEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEI 265
E E EK + + + N+ + Q + LEM+ + LQ+QL S+ M L++E+
Sbjct: 3110 REQESEKPSQELLEYNIQ-QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3168
Query: 266 AHSQVKQEAVL--LHEKLYELESHR-------DQMIAEDKSIGSPMEEREKLLKQIKDDN 316
A ++++ E L H+ L ELE+ R D++ + ++ S ++ +L ++ +
Sbjct: 3169 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEK 3228
Query: 317 QEIASME----RQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFI 372
++ E +L D K + + QL++ LE+ + +N+ ++++ + D +
Sbjct: 3229 AKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQL 3288
Query: 373 ETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEV 432
E+ +N EL+ LLE S + RI ++SS ++E ++ + T
Sbjct: 3289 SE-EQGRNLELQ----------VLLE--SEKV-RIREMSSTLDRERELHAQLQSSDGTGQ 3334
Query: 433 QKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKS--KIKQMTTDLEIY-NDLPA 489
+ +++L ++Q+ QL+ + ++E E++ L S +QM D +++ L
Sbjct: 3335 SRPPLPSEDLLKELQK-QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3393
Query: 490 LKSSGEEKIKKLHQ--------ERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQ 541
+ + E KK+H+ +R + + +K +E Q ++ + Q QE E +
Sbjct: 3394 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEK 3453
Query: 542 LTNLERKWQHLEQ-----------NNFAMKEFIATKSQESDY 572
+ +Q+L + N+ +++ I +++ES+Y
Sbjct: 3454 RESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNY 3495
Score = 69.3 bits (168), Expect = 9e-12
Identities = 94/435 (21%), Positives = 189/435 (43%), Gaps = 54/435 (12%)
Query: 111 EVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLA-DYNMLVDKLNTNTEMEEV 169
EV + +EM +E + L ++ AE+ E++ L+ QL + + KL + E+E
Sbjct: 592 EVTNYKIKLEMLEKEKNAVL--DRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Query: 170 MNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEE-----------EIEQEKQATDDI 218
+N + Q +D + E K + ++ ++ EI + K +
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709
Query: 219 IKNMSFENQVKYLEMKTTNEKLLQE---LDTLQQQLDSQNMKKESLEAEIAHSQVKQEAV 275
+ + S E ++ E++ E L QE TL+Q++ +K E LE Q+K++
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE-----KQMKEKEN 764
Query: 276 LLHEKLYELESHRDQMIAEDKS------IGSPMEEREKLL------KQIKDD--NQEIAS 321
L EK +LE+ + E K+ I +P+ + E+L+ + KD +EI
Sbjct: 765 DLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824
Query: 322 MERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKN- 380
+ + D K++ Q EEI + + Y+EL++ + + E++KN
Sbjct: 825 LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884
Query: 381 QELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQ 440
QEL+ K++++A +N + I +KM + T V ++ +
Sbjct: 885 QELEYKSKLKA------------LNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGE 932
Query: 441 NLTSDIQRL--QLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYN-DLPALKSSGEEK 497
+ D L +L++ K E LE +++ L ++KQ ++ N ++ +LK E+
Sbjct: 933 VVEKDTTELMEKLEVTKREKLE--LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990
Query: 498 IKKLHQERMILSTHR 512
+ + +I++ +R
Sbjct: 991 SLRCRELEIIINHNR 1005
Score = 62.4 bits (150), Expect = 1e-09
Identities = 94/496 (18%), Positives = 219/496 (44%), Gaps = 68/496 (13%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSL----D 188
E+ A+ ++ ++ +LA +++LN E+EE+ Y Q +E ++ D
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNR--ELEEMRVTYGTEGLQQLQEFEAAIKQRD 204
Query: 189 VIFTERQAKEKQIRSVEEE-------IEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLL 241
I T+ A +Q R ++E + ++ Q + + ++ +T LL
Sbjct: 205 GIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLL 264
Query: 242 Q---ELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSI 298
Q ++ T QQQL+ Q+ E + + + L EK+ E +D+ + + S
Sbjct: 265 QAKQQILTHQQQLEEQDHLLEDYQKK--KEDFTMQISFLQEKIKVYEMEQDKKV--ENSN 320
Query: 299 GSPMEEREKLLKQIKDDNQEIASMERQLTDTKEK-------INQFIEEIRQLDMDLEEHQ 351
++E+E +++++ N +I E++ + K+K + + E+I Q + +++ +
Sbjct: 321 KEEIQEKETIIEEL---NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 377
Query: 352 GEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQI- 410
E+ ++ ++ E + + T EE + + K +Q E +IV +E ++ ++EQ+
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHK-DSQFETDIVQRMEQETQ--RKLEQLR 434
Query: 411 ---------------SSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQK 455
+ Q + M++ E++ + + N+T + +++L
Sbjct: 435 AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA 494
Query: 456 MELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAF 515
+ L K+ ++ +S K K+K+ I + AL+ E+ +++L R + R
Sbjct: 495 INELNIKL-QDTNSQKEKLKEELG--LILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551
Query: 516 KKIMEKQNIEYEALKT---------------QLQENETHSQLTNLERKWQHLEQNNFAMK 560
+ K N +++L T + E + +++TN + K + LE+ A+
Sbjct: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
Query: 561 EFIATKSQESDYQPIK 576
+ +A +SQE++ + ++
Sbjct: 612 DRMA-ESQEAELERLR 626
Score = 61.6 bits (148), Expect = 2e-09
Identities = 83/483 (17%), Positives = 201/483 (41%), Gaps = 68/483 (14%)
Query: 107 ELTTEVNKLQKG-IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTE 165
+L E KL K +E+ Q V +K+ + L ++++E + + NTE
Sbjct: 1993 QLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ-----EKNTE 2047
Query: 166 MEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDII-----K 220
+ ++ L+ Q ++ + LD +R+ + + +++EQ+ + +
Sbjct: 2048 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ 2107
Query: 221 NMSFENQVKYLEMKTTN-EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHE 279
E +L+ KT +LL + LQ+ + +N + E LE + + +A+L+
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE---QALLVSA 2164
Query: 280 KLYE----------------------LESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQ 317
++ L++ RD + ++K I + E+ E+ +++++ N+
Sbjct: 2165 DTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNE 2224
Query: 318 EIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEE 377
E+ + QL K++ ++E+ Q E K ++ M+ +E
Sbjct: 2225 EVQQLHMQLEIQKKESTTRLQELEQ-----------------ENKLFKDDMEKLGLAIKE 2267
Query: 378 TKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQS 437
+ + + + +++ I+++ + + Q+LK+ D + +++
Sbjct: 2268 SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD-----NKVIEEKNE 2322
Query: 438 TAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKS-SGEE 496
++L + I+ L D E ++ EE L I+++ +L ++ + S E
Sbjct: 2323 LIRDLETQIECLMSD---QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2379
Query: 497 KIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQE-----NETHSQLTNLERKWQH 551
+ L + ++ + A ++ +E N E +K L+E N+ +L +L+R+ +
Sbjct: 2380 EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERES 2439
Query: 552 LEQ 554
+E+
Sbjct: 2440 VEK 2442
Score = 47.0 bits (110), Expect = 5e-05
Identities = 68/336 (20%), Positives = 145/336 (43%), Gaps = 51/336 (15%)
Query: 238 EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVL-------LHEKLYELESHRDQ 290
EKLL+ + QL+ + + L E KQEA L E+L+E R+Q
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQ--KQEATESLKCQEELRERLHEESRAREQ 1912
Query: 291 MIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEH 350
+ E + + E ++ D+ ERQ+ + + I++ +E+ L+E
Sbjct: 1913 LAVE-------LSKAEGVIDGYADEK---TLFERQIQEKTDIIDRLEQELLCASNRLQEL 1962
Query: 351 QGEMNQKYKE---LKKREEHMDTFIETFEETKNQE----LKRKAQIEANIVALLEHCSRN 403
+ E Q +E L +++E M E+ QE +K K +++ + + +
Sbjct: 1963 EAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ 2022
Query: 404 INRIE-QISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKM-ELLES 461
+ +E + ++ +++ Q+ K+TE+ +L Q L+ L+KM + L+
Sbjct: 2023 VKALEIDVEEQVSRFIELEQE----KNTEL-------MDLRQQNQALEKQLEKMRKFLDE 2071
Query: 462 KMTEEQHS---LKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKI 518
+ + +H + +I+++ L++ +P + E + +++ Q L+ H
Sbjct: 2072 QAIDREHERDVFQQEIQKLEQQLKV---VPRFQPISEHQTREVEQ----LANHLKEKTDK 2124
Query: 519 MEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQ 554
+ + E L+ +QE + ++ LE + + LEQ
Sbjct: 2125 CSELLLSKEQLQRDIQER--NEEIEKLEFRVRELEQ 2158
Score = 44.7 bits (104), Expect = 2e-04
Identities = 74/350 (21%), Positives = 146/350 (41%), Gaps = 55/350 (15%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT 192
EK A L +I +L+ + +Y T + E N N+ + + D + +
Sbjct: 2549 EKVAAALVSQI-QLEA-VQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTL 2606
Query: 193 ERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTT---NEKLLQELDTLQQ 249
E Q+ + + EK+ + KN+ E + K LE++ NEK +E + +
Sbjct: 2607 RISELESQVVEMHTSLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNEKKQREKEKKRS 2665
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLL 309
D + +K + E+ HS +E+ +E LE+ R + +A + S E+ EKL
Sbjct: 2666 PQDVEVLKTTT---ELFHSN--EESGFFNE----LEALRAESVATKAELASYKEKAEKL- 2715
Query: 310 KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMD 369
+E+ E +T ++ ++Q + +H E +K L+K
Sbjct: 2716 ------QEELLVKETNMTSLQKDLSQ-----------VRDHLAEAKEKLSILEKE----- 2753
Query: 370 TFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKS 429
+ET+ QE K+ E + L + + + +ISS +NQ +++ + +
Sbjct: 2754 ------DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISS-SNQTPQILVKNAGIQI 2806
Query: 430 TEVQKSQSTAQNLTSDIQRLQLDLQKMELL--------ESKMTEEQHSLK 471
+S+ +++ +T I + ++KM+ L ES+ E +LK
Sbjct: 2807 N--LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLK 2854
Score = 42.0 bits (97), Expect = 0.002
Identities = 89/454 (19%), Positives = 184/454 (40%), Gaps = 47/454 (10%)
Query: 111 EVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTE----- 165
+ +L + +E+ +E L +R L+ ++K+ G+++ N V L E
Sbjct: 937 DTTELMEKLEVTKREK---LELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLR 993
Query: 166 ---MEEVMNDYNMLKAQN-DRETQSL--DVIFTERQAKEKQIRSVEEEIEQEKQATDDII 219
+E ++N Q+ D + SL V+ + E + V + +E + +
Sbjct: 994 CRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM--VE 1051
Query: 220 KNMSFENQVKYLEMKTTNEKLLQELDTLQQQLD---SQNMKKESLEAEIAHSQVKQEAVL 276
+SFEN E K + +L L ++ ++ +Q + + L+ E+ + +Q +
Sbjct: 1052 DKVSFENMTVGEESKQ-EQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLR 1110
Query: 277 LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQF 336
L ++E+ R I + +++ + ++ KD + + S++ +L +E+ +
Sbjct: 1111 L-----QMEAQR---ICLSLVYSTHVDQVREYMENEKD--KALCSLKEELIFAQEEKIKE 1160
Query: 337 IEEIRQLDMDLEEHQGEMNQKYKEL--------KKREEHMDTFIETFEETKNQELKRKAQ 388
+++I QL++ + Q E + K L K E F++T + +
Sbjct: 1161 LQKIHQLELQTMKTQ-ETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALK 1219
Query: 389 IEANIVALL---EHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSD 445
E N ++ S N + Q Q+ + L K TE Q S
Sbjct: 1220 CEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSK 1279
Query: 446 IQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTT----DLEIYNDLPALKSSGEEKIKKL 501
I Q D K+E E + +E+ S QMT D+ + L +L+ + K+++
Sbjct: 1280 IWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQ 1339
Query: 502 HQE-RMILSTHRNAFKKIMEKQNIEYEALKTQLQ 534
QE ++S+ + K+ + E L+ +LQ
Sbjct: 1340 VQELESLISSLQQQLKETEQNYEAEIHCLQKRLQ 1373
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 98.6 bits (244), Expect = 1e-20
Identities = 113/516 (21%), Positives = 245/516 (47%), Gaps = 49/516 (9%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVE--IKE 145
Q+Q+ ++ + L + K + T +++ LQ+ I++Y E + + E E I+E
Sbjct: 274 QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEE 333
Query: 146 LQGQLADYNM----LVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT-----ERQA 196
L ++ + L DKL T ++++ + Q ++E +++ + T ERQ+
Sbjct: 334 LNTKIIEEEKKTLELKDKLTT---ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQS 390
Query: 197 KE--KQIRSVEEEIEQ----EKQATDDIIKNMSFENQVKYLEMKTTNEKLL-QELDTLQQ 249
E KQ+ EE+++ + Q DI++ M E Q K +++ +++ Q++ ++Q
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE----R 305
+L Q+M + E + H + A+ + + E M + +++ +
Sbjct: 451 ELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKRE 365
EKL +++ +E +++RQL D E+++ E+I++ + E + ++N+ +K L E
Sbjct: 510 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569
Query: 366 EHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRI-EQISSITNQELKMMQDD 424
+ + E K ELK +A++ N LE + N + ++++ EL+ ++
Sbjct: 570 DLKAEIVSASESRKELELKHEAEV-TNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ 628
Query: 425 LNFK-STEVQKSQSTAQ-NLTSDIQRLQLDL-----QKMELLESKMTE-------EQHSL 470
L F E+ K + + +I++L+ +L Q+++ L+++M++ E+ +L
Sbjct: 629 LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL 688
Query: 471 KSKIKQMTTDLEIYNDL--PALKSSGEE---KIKKLHQERMILSTHRNAFKKIMEKQNIE 525
+K Q+ ++ DL + S EE +I +L +E IL +K +Q ++
Sbjct: 689 ITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK--EKGTLEQEVQ 746
Query: 526 YEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKE 561
LKT+L E + + +L+ K+ LE N +K+
Sbjct: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD 782
Score = 75.1 bits (183), Expect = 2e-13
Identities = 115/523 (21%), Positives = 221/523 (42%), Gaps = 84/523 (16%)
Query: 94 KSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADY 153
K L+ SK E+T ++N+LQK IE+ QE EK TL E++ELQ +
Sbjct: 703 KDLQQSLVNSKSEEMTLQINELQKEIEILRQE-------EKEKGTLEQEVQELQLKTE-- 753
Query: 154 NMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQ 213
L++K +M+E ND AQ + E ++ E++ E ++ ++E+
Sbjct: 754 --LLEK-----QMKEKENDLQEKFAQLEAENS---ILKDEKKTLEDMLKIHTPVSQEERL 803
Query: 214 ATDDIIKNMS----FENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEA--EIAH 267
D IK+ S +E +++ L + NE L Q+ L ++++ Q E E+ +
Sbjct: 804 IFLDSIKSKSKDSVWEKEIEILIEE--NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
Query: 268 SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEER----------EKLLKQIKDDNQ 317
++++E L + +LE +++ E KS + E K+ + D+++
Sbjct: 862 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921
Query: 318 EIAS--------MERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMD 369
+ +E+ T+ EK+ E +L L + ++ QK+ E+ E
Sbjct: 922 TFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEE-- 979
Query: 370 TFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKS 429
+++ ++ K Q R ++E I N NR E + S Q ++ + S
Sbjct: 980 --VKSLKQEKEQVSLRCRELEIII---------NHNRAENVQSCDTQVSSLLDGVVTMTS 1028
Query: 430 TEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSL--KSKIKQMTTD-LEIYND 486
+ S S + ++ ++E K++ E ++ +SK +Q+ D L
Sbjct: 1029 RGAEGSVSKVNKSFGEESKI--------MVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080
Query: 487 LPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKT-------QLQENETH 539
+L+++ + KL +E +L + +N + ME Q I + + + ENE
Sbjct: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
Query: 540 SQLTNLERKWQHLEQNNFAMKEFI--ATKSQESDYQPIKKNVT 580
L +L+ E+ FA +E I K + + Q +K T
Sbjct: 1141 KALCSLK------EELIFAQEEKIKELQKIHQLELQTMKTQET 1177
Score = 70.9 bits (172), Expect = 3e-12
Identities = 109/522 (20%), Positives = 233/522 (44%), Gaps = 70/522 (13%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLA----VEIKELQGQLADYNMLVD 158
S + +L T++ +LQ+ E+Y+ S + R E L V ++E LA + +
Sbjct: 2984 SSLKDLITKM-QLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3042
Query: 159 KLNTNTEMEEVMNDYNMLKAQNDRETQSL---------DVIFTERQAKEKQIR----SVE 205
L T T+ ++N + E Q+ + +E QA Q+ +++
Sbjct: 3043 ALGT-TDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLK 3101
Query: 206 EEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEI 265
E E EK + + + N+ + Q + LEM+ + LQ+QL S+ M L++E+
Sbjct: 3102 REQESEKPSQELLEYNIQ-QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3160
Query: 266 AHSQVKQEAVL--LHEKLYELESHR-------DQMIAEDKSIGSPMEEREKLLKQIKDDN 316
A ++++ E L H+ L ELE+ R D++ + ++ S ++ +L ++ +
Sbjct: 3161 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEK 3220
Query: 317 QEIASME----RQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFI 372
++ E +L D K + + QL++ LE+ + +N+ ++++ + D +
Sbjct: 3221 AKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQL 3280
Query: 373 ETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEV 432
E+ +N EL+ LLE S + RI ++SS ++E ++ + T
Sbjct: 3281 SE-EQGRNLELQ----------VLLE--SEKV-RIREMSSTLDRERELHAQLQSSDGTGQ 3326
Query: 433 QKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKS--KIKQMTTDLEIY-NDLPA 489
+ +++L ++Q+ QL+ + ++E E++ L S +QM D +++ L
Sbjct: 3327 SRPPLPSEDLLKELQK-QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3385
Query: 490 LKSSGEEKIKKLHQ--------ERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQ 541
+ + E KK+H+ +R + + +K +E Q ++ + Q QE E +
Sbjct: 3386 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEK 3445
Query: 542 LTNLERKWQHLEQ-----------NNFAMKEFIATKSQESDY 572
+ +Q+L + N+ +++ I +++ES+Y
Sbjct: 3446 RESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNY 3487
Score = 69.3 bits (168), Expect = 9e-12
Identities = 94/435 (21%), Positives = 189/435 (43%), Gaps = 54/435 (12%)
Query: 111 EVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLA-DYNMLVDKLNTNTEMEEV 169
EV + +EM +E + L ++ AE+ E++ L+ QL + + KL + E+E
Sbjct: 592 EVTNYKIKLEMLEKEKNAVL--DRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Query: 170 MNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEE-----------EIEQEKQATDDI 218
+N + Q +D + E K + ++ ++ EI + K +
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709
Query: 219 IKNMSFENQVKYLEMKTTNEKLLQE---LDTLQQQLDSQNMKKESLEAEIAHSQVKQEAV 275
+ + S E ++ E++ E L QE TL+Q++ +K E LE Q+K++
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE-----KQMKEKEN 764
Query: 276 LLHEKLYELESHRDQMIAEDKS------IGSPMEEREKLL------KQIKDD--NQEIAS 321
L EK +LE+ + E K+ I +P+ + E+L+ + KD +EI
Sbjct: 765 DLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824
Query: 322 MERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKN- 380
+ + D K++ Q EEI + + Y+EL++ + + E++KN
Sbjct: 825 LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884
Query: 381 QELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQ 440
QEL+ K++++A +N + I +KM + T V ++ +
Sbjct: 885 QELEYKSKLKA------------LNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGE 932
Query: 441 NLTSDIQRL--QLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYN-DLPALKSSGEEK 497
+ D L +L++ K E LE +++ L ++KQ ++ N ++ +LK E+
Sbjct: 933 VVEKDTTELMEKLEVTKREKLE--LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990
Query: 498 IKKLHQERMILSTHR 512
+ + +I++ +R
Sbjct: 991 SLRCRELEIIINHNR 1005
Score = 68.6 bits (166), Expect = 2e-11
Identities = 109/518 (21%), Positives = 208/518 (40%), Gaps = 96/518 (18%)
Query: 130 LSYEKRA-ETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLD 188
L E RA E LAVE+ + +G + Y ++ + + Q +T +D
Sbjct: 1903 LHEESRAREQLAVELSKAEGVIDGY----------------ADEKTLFERQIQEKTDIID 1946
Query: 189 VIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTL- 247
+ E ++ +E+E E+Q + + +S + + E ++LLQE + L
Sbjct: 1947 RLEQELLCASNRL----QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
Query: 248 QQQLDSQ--------NMKKESLEAEI-AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSI 298
+++L+ Q +++K+ EI QV + L EK EL R Q A +K +
Sbjct: 2003 KEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQL 2062
Query: 299 GSP------------------MEEREKLLKQIK----------DDNQEIASMERQLTDTK 330
+E +KL +Q+K +E+ + L +
Sbjct: 2063 EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT 2122
Query: 331 EKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIE 390
+K ++ + QL D++E E+ + E + RE +E + E K + +E
Sbjct: 2123 DKCSELLLSKEQLQRDIQERNEEIEK--LEFRVRELEQALLVEDRKHFGAVEAKPELSLE 2180
Query: 391 ANIVA---LLEHCSRNINRIEQISSITNQELKMMQDDLN--FKSTEVQKSQSTA--QNLT 443
+ A ++ + I +E+ +EL+ +++ E+QK +ST Q L
Sbjct: 2181 VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELE 2240
Query: 444 SDIQRLQLDLQKMELL----ESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIK 499
+ + + D++K+ L ++ T++QH L K Q+ + E+ D E++
Sbjct: 2241 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEID------QLNEQVT 2294
Query: 500 KLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQ------------ENETHSQLTNLER 547
KL Q+ I + + K++E++N L+TQ++ E QL +
Sbjct: 2295 KLQQQLKITTDN-----KVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2349
Query: 548 KWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAE 585
K Q E N K + S + +K + IAE
Sbjct: 2350 KLQQ-ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE 2386
Score = 66.6 bits (161), Expect = 6e-11
Identities = 83/475 (17%), Positives = 203/475 (42%), Gaps = 60/475 (12%)
Query: 107 ELTTEVNKLQKG-IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTE 165
+L E KL K +E+ Q V +K+ + L ++++E + + NTE
Sbjct: 1993 QLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ-----EKNTE 2047
Query: 166 MEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDII-----K 220
+ ++ L+ Q ++ + LD +R+ + + +++EQ+ + +
Sbjct: 2048 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ 2107
Query: 221 NMSFENQVKYLEMKTTN-EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHE 279
E +L+ KT +LL + LQ+ + +N + E LE + + +A+L+ +
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE---QALLVED 2164
Query: 280 KLY--------------ELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQ 325
+ + +L++ RD + ++K I + E+ E+ +++++ N+E+ + Q
Sbjct: 2165 RKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224
Query: 326 LTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKR 385
L K++ ++E+ Q E K ++ M+ +E+ +
Sbjct: 2225 LEIQKKESTTRLQELEQ-----------------ENKLFKDDMEKLGLAIKESDAMSTQD 2267
Query: 386 KAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSD 445
+ + +++ I+++ + + Q+LK+ D + +++ ++L +
Sbjct: 2268 QHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD-----NKVIEEKNELIRDLETQ 2322
Query: 446 IQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKS-SGEEKIKKLHQE 504
I+ L D E ++ EE L I+++ +L ++ + S E+ L +
Sbjct: 2323 IECLMSD---QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQ 2379
Query: 505 RMILSTHRNAFKKIMEKQNIEYEALKTQLQE-----NETHSQLTNLERKWQHLEQ 554
++ + A ++ +E N E +K L+E N+ +L +L+R+ + +E+
Sbjct: 2380 LDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK 2434
Score = 62.4 bits (150), Expect = 1e-09
Identities = 94/496 (18%), Positives = 219/496 (44%), Gaps = 68/496 (13%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSL----D 188
E+ A+ ++ ++ +LA +++LN E+EE+ Y Q +E ++ D
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNR--ELEEMRVTYGTEGLQQLQEFEAAIKQRD 204
Query: 189 VIFTERQAKEKQIRSVEEE-------IEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLL 241
I T+ A +Q R ++E + ++ Q + + ++ +T LL
Sbjct: 205 GIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLL 264
Query: 242 Q---ELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSI 298
Q ++ T QQQL+ Q+ E + + + L EK+ E +D+ + + S
Sbjct: 265 QAKQQILTHQQQLEEQDHLLEDYQKK--KEDFTMQISFLQEKIKVYEMEQDKKV--ENSN 320
Query: 299 GSPMEEREKLLKQIKDDNQEIASMERQLTDTKEK-------INQFIEEIRQLDMDLEEHQ 351
++E+E +++++ N +I E++ + K+K + + E+I Q + +++ +
Sbjct: 321 KEEIQEKETIIEEL---NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 377
Query: 352 GEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQI- 410
E+ ++ ++ E + + T EE + + K +Q E +IV +E ++ ++EQ+
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHK-DSQFETDIVQRMEQETQ--RKLEQLR 434
Query: 411 ---------------SSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQK 455
+ Q + M++ E++ + + N+T + +++L
Sbjct: 435 AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA 494
Query: 456 MELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAF 515
+ L K+ ++ +S K K+K+ I + AL+ E+ +++L R + R
Sbjct: 495 INELNIKL-QDTNSQKEKLKEELG--LILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551
Query: 516 KKIMEKQNIEYEALKT---------------QLQENETHSQLTNLERKWQHLEQNNFAMK 560
+ K N +++L T + E + +++TN + K + LE+ A+
Sbjct: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
Query: 561 EFIATKSQESDYQPIK 576
+ +A +SQE++ + ++
Sbjct: 612 DRMA-ESQEAELERLR 626
Score = 47.0 bits (110), Expect = 5e-05
Identities = 68/336 (20%), Positives = 145/336 (43%), Gaps = 51/336 (15%)
Query: 238 EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVL-------LHEKLYELESHRDQ 290
EKLL+ + QL+ + + L E KQEA L E+L+E R+Q
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQ--KQEATESLKCQEELRERLHEESRAREQ 1912
Query: 291 MIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEH 350
+ E + + E ++ D+ ERQ+ + + I++ +E+ L+E
Sbjct: 1913 LAVE-------LSKAEGVIDGYADEK---TLFERQIQEKTDIIDRLEQELLCASNRLQEL 1962
Query: 351 QGEMNQKYKE---LKKREEHMDTFIETFEETKNQE----LKRKAQIEANIVALLEHCSRN 403
+ E Q +E L +++E M E+ QE +K K +++ + + +
Sbjct: 1963 EAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ 2022
Query: 404 INRIE-QISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKM-ELLES 461
+ +E + ++ +++ Q+ K+TE+ +L Q L+ L+KM + L+
Sbjct: 2023 VKALEIDVEEQVSRFIELEQE----KNTEL-------MDLRQQNQALEKQLEKMRKFLDE 2071
Query: 462 KMTEEQHS---LKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKI 518
+ + +H + +I+++ L++ +P + E + +++ Q L+ H
Sbjct: 2072 QAIDREHERDVFQQEIQKLEQQLKV---VPRFQPISEHQTREVEQ----LANHLKEKTDK 2124
Query: 519 MEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQ 554
+ + E L+ +QE + ++ LE + + LEQ
Sbjct: 2125 CSELLLSKEQLQRDIQER--NEEIEKLEFRVRELEQ 2158
Score = 44.7 bits (104), Expect = 2e-04
Identities = 74/350 (21%), Positives = 146/350 (41%), Gaps = 55/350 (15%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT 192
EK A L +I +L+ + +Y T + E N N+ + + D + +
Sbjct: 2541 EKVAAALVSQI-QLEA-VQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTL 2598
Query: 193 ERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTT---NEKLLQELDTLQQ 249
E Q+ + + EK+ + KN+ E + K LE++ NEK +E + +
Sbjct: 2599 RISELESQVVEMHTSLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNEKKQREKEKKRS 2657
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLL 309
D + +K + E+ HS +E+ +E LE+ R + +A + S E+ EKL
Sbjct: 2658 PQDVEVLKTTT---ELFHSN--EESGFFNE----LEALRAESVATKAELASYKEKAEKL- 2707
Query: 310 KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMD 369
+E+ E +T ++ ++Q + +H E +K L+K
Sbjct: 2708 ------QEELLVKETNMTSLQKDLSQ-----------VRDHLAEAKEKLSILEKE----- 2745
Query: 370 TFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKS 429
+ET+ QE K+ E + L + + + +ISS +NQ +++ + +
Sbjct: 2746 ------DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISS-SNQTPQILVKNAGIQI 2798
Query: 430 TEVQKSQSTAQNLTSDIQRLQLDLQKMELL--------ESKMTEEQHSLK 471
+S+ +++ +T I + ++KM+ L ES+ E +LK
Sbjct: 2799 N--LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLK 2846
Score = 42.0 bits (97), Expect = 0.002
Identities = 89/454 (19%), Positives = 184/454 (40%), Gaps = 47/454 (10%)
Query: 111 EVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTE----- 165
+ +L + +E+ +E L +R L+ ++K+ G+++ N V L E
Sbjct: 937 DTTELMEKLEVTKREK---LELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLR 993
Query: 166 ---MEEVMNDYNMLKAQN-DRETQSL--DVIFTERQAKEKQIRSVEEEIEQEKQATDDII 219
+E ++N Q+ D + SL V+ + E + V + +E + +
Sbjct: 994 CRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM--VE 1051
Query: 220 KNMSFENQVKYLEMKTTNEKLLQELDTLQQQLD---SQNMKKESLEAEIAHSQVKQEAVL 276
+SFEN E K + +L L ++ ++ +Q + + L+ E+ + +Q +
Sbjct: 1052 DKVSFENMTVGEESKQ-EQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLR 1110
Query: 277 LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQF 336
L ++E+ R I + +++ + ++ KD + + S++ +L +E+ +
Sbjct: 1111 L-----QMEAQR---ICLSLVYSTHVDQVREYMENEKD--KALCSLKEELIFAQEEKIKE 1160
Query: 337 IEEIRQLDMDLEEHQGEMNQKYKEL--------KKREEHMDTFIETFEETKNQELKRKAQ 388
+++I QL++ + Q E + K L K E F++T + +
Sbjct: 1161 LQKIHQLELQTMKTQ-ETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALK 1219
Query: 389 IEANIVALL---EHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSD 445
E N ++ S N + Q Q+ + L K TE Q S
Sbjct: 1220 CEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSK 1279
Query: 446 IQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTT----DLEIYNDLPALKSSGEEKIKKL 501
I Q D K+E E + +E+ S QMT D+ + L +L+ + K+++
Sbjct: 1280 IWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQ 1339
Query: 502 HQE-RMILSTHRNAFKKIMEKQNIEYEALKTQLQ 534
QE ++S+ + K+ + E L+ +LQ
Sbjct: 1340 VQELESLISSLQQQLKETEQNYEAEIHCLQKRLQ 1373
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 96.7 bits (239), Expect = 6e-20
Identities = 103/465 (22%), Positives = 207/465 (44%), Gaps = 27/465 (5%)
Query: 107 ELTTEVNKLQKGIE-MYNQENSVYLSYEKRAETLAVEIKELQGQ-LADYNMLVDKLNTNT 164
++ + + K QK + + +E S+ Y + + E +E + + L+ L + L
Sbjct: 1441 QVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 165 EME----EVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVE---EEIEQEKQATDD 217
E E ++ D L + D +++ + ++A E+Q+ + EE+E E QAT+D
Sbjct: 1501 EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED 1560
Query: 218 IIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKK-ESLEAEIAHSQVKQEAVL 276
+ Q MK E+ LQ D ++ +K+ LEAE+ + ++ +
Sbjct: 1561 AKLRLEVNMQA----MKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV 1616
Query: 277 LHEKLYE--LESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN 334
+K E L+ Q+ A +K+ +++ KL Q+KD +E+ + +
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK 1676
Query: 335 QFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEET---KNQELKRKAQIEA 391
+ ++++ L+ ++ + Q E+ + + E+ D + + K+ L K ++EA
Sbjct: 1677 ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEA 1736
Query: 392 NIVALLEHCSRNINRIEQISSI---TNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQR 448
I L E + +E ++ T ++ + +L + + QKS + Q L +
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796
Query: 449 LQLDLQKME-LLESKMTEEQHSLKSKIKQMTTDLEIYNDLPA----LKSSGEEKIKKLHQ 503
L+ LQ++E ++SK +L++KI Q+ LE A L E+K+K++
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856
Query: 504 ERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERK 548
+ H + +K+ MEK N + LK QL+E E + N R+
Sbjct: 1857 QVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRR 1901
Score = 86.7 bits (213), Expect = 6e-17
Identities = 116/515 (22%), Positives = 225/515 (43%), Gaps = 47/515 (9%)
Query: 105 ISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADY---NMLVDKLN 161
+ EL ++ +LQ+ E E + EK+ L+ E++ L+ +L D +L
Sbjct: 1113 VRELQAQIAELQEDFE---SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR 1169
Query: 162 TNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
T E E + + + E Q D+ RQ + + E++EQ K+ ++ KN
Sbjct: 1170 TKREQEVAELKKALEEETKNHEAQIQDM----RQRHATALEELSEQLEQAKRFKANLEKN 1225
Query: 222 ---MSFEN-----QVKYLE-MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH--SQV 270
+ +N +VK L+ +K +E ++LD Q+L ++ + + L E+A S++
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKL 1285
Query: 271 KQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTK 330
+ E + L E E + + S+ S +++ ++LL++ ++S RQL + K
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 331 EKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIE 390
+ + EE + +LE+ + + + KK+ + IE+ EE K + LK +
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 391 ANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQ 450
LE + +++E+ + QEL DDL + ++ + A NL ++
Sbjct: 1406 QR----LEEKALAYDKLEKTKNRLQQEL----DDL---TVDLDHQRQVASNLEKKQKKFD 1454
Query: 451 LDLQKMELLESKMTEEQHSLKSKIKQMTTD-LEIYNDLPALKSSGEEKIKKLHQERM--- 506
L + + + ++ EE+ +++ ++ T L + L + EE ++ Q R
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 507 -ILSTHRNAFKKIMEKQNI------EYEALKTQLQENETHSQLTNLERKWQHLEQNNFAM 559
++S+ + K + E + + E ++TQL+E E Q T E LE N AM
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT--EDAKLRLEVNMQAM 1572
Query: 560 KEFIATKSQESDYQPIKKN--VTKQIAEYNKTIVD 592
K Q D Q +K + KQ+ E + D
Sbjct: 1573 KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/617 (20%), Positives = 271/617 (43%), Gaps = 120/617 (19%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAET-LAVEIKEL 146
+ ++ K L ++ K +++ E+ ++++ + +E ++ L+ + +AET L E +E+
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI-LAEQLQAETELFAEAEEM 909
Query: 147 QGQLA----DYNMLVDKLNTNTEMEEVMNDYNM------------LKAQNDRETQSLDVI 190
+ +LA + ++ L + E EE N L+ Q D E + +
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL 969
Query: 191 FTERQAKEKQIRSVEEEI----------EQEKQATDDIIKNMSF-----ENQVKYL---- 231
E+ E +I+ +EEEI +EK+ +D I S E + K L
Sbjct: 970 QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIR 1029
Query: 232 -----------EMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEK 280
E EK QEL+ +++LD + + AE+ +Q+ + + L +K
Sbjct: 1030 NKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL-QAQIDELKLQLAKK 1088
Query: 281 LYELES----------HRDQ----------MIAE-DKSIGSPMEEREKLLKQIKDDNQEI 319
EL+ H++ IAE + S R K KQ +D ++E+
Sbjct: 1089 EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEEL 1148
Query: 320 ASMERQLTDT----------KEKINQFIEEIRQ-LDMDLEEHQG---EMNQKY----KEL 361
+++ +L DT + K Q + E+++ L+ + + H+ +M Q++ +EL
Sbjct: 1149 EALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEEL 1208
Query: 362 KKREEHMDTFIETFE------ETKNQELKRKAQIEANIVALLEHCSRNIN-RIEQISSIT 414
++ E F E ET N+EL + ++ + A EH + ++ +++++ +
Sbjct: 1209 SEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV 1268
Query: 415 N----------QELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMT 464
+ ++ +Q++L+ ST +++++ D L+ LQ + L + T
Sbjct: 1269 SEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEET 1328
Query: 465 EEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEK--- 521
++ +L S+I+Q+ E N L + EE K L ++ + L + KK ++
Sbjct: 1329 RQKLNLSSRIRQLE---EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLG 1385
Query: 522 --QNIEYEALKTQLQENETHSQLTNLERK---WQHLEQNNFAMKEFIATKSQESDYQ-PI 575
+++E EA K L++ E SQ LE K + LE+ +++ + + + D+Q +
Sbjct: 1386 TIESLE-EAKKKLLKDAEALSQ--RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442
Query: 576 KKNVTKQIAEYNKTIVD 592
N+ K+ ++++ + +
Sbjct: 1443 ASNLEKKQKKFDQLLAE 1459
Score = 65.1 bits (157), Expect = 2e-10
Identities = 82/426 (19%), Positives = 187/426 (43%), Gaps = 35/426 (8%)
Query: 179 QNDRETQSLDVI-FTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTN 237
+ +R+ + D+I F + + R + +Q+ A + +N + ++++ +
Sbjct: 779 EEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVF 838
Query: 238 EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKS 297
K+ L +Q+ + Q +E L+ VK++ + +L E+E Q++ E
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLK-------VKEKQTKVEGELEEMERKHQQLLEEKNI 891
Query: 298 IGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQK 357
+ ++ +L + ++ +A+ +++L + + +EE EE + ++ Q
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--------EEERNQILQ- 942
Query: 358 YKELKKREEHMDTFIETFEETKNQELKRKAQIE-ANIVALLEHCSRNINRIEQISSITNQ 416
E KK + H+ E +E + ++K Q+E A ++ I +E +S +
Sbjct: 943 -NEKKKMQAHIQDLEEQLDE--EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999
Query: 417 ELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQL---DLQKMELLESKMTEEQHSLKSK 473
E K+M+D + S+++ + + A+NL + ++ DL++ E K +E K K
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059
Query: 474 IKQMTTDLEIYNDLPALKSSGEE-KIKKLHQERMILSTHRNAFKKIMEKQNI-----EYE 527
+ TTDL+ + + L++ +E K++ +E + + + K N E +
Sbjct: 1060 LDGETTDLQ--DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117
Query: 528 ALKTQLQEN--ETHSQLTNLERKWQHLEQNNFAMK-EFIATKSQESDYQPIKKNVTKQIA 584
A +LQE+ + E++ + L + A+K E T + Q ++ +++A
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177
Query: 585 EYNKTI 590
E K +
Sbjct: 1178 ELKKAL 1183
Score = 64.7 bits (156), Expect = 2e-10
Identities = 80/365 (21%), Positives = 153/365 (41%), Gaps = 56/365 (15%)
Query: 107 ELTTEVNKLQKGIEMYNQE--------NSVYLSY---EKRAETLAVEIKELQGQLADYNM 155
E+ ++ KLQ ++ Y +E + ++ EK+ ++L EI +LQ +LA
Sbjct: 1642 EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Query: 156 LVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQAT 215
+ + E +E+ ++ + E++ E +I +EEE+E+E+
Sbjct: 1702 A--RRHAEQERDELADEIT-------NSASGKSALLDEKRRLEARIAQLEEELEEEQSNM 1752
Query: 216 DDIIKNMSFENQVKYLEMKTTNEKLL------QELDTLQQQLDSQNM----KKESLEAEI 265
+ + N F L++ T N +L Q+ D +QQL+ QN K + LE +
Sbjct: 1753 E--LLNDRFRKTT--LQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808
Query: 266 AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQ 325
S+ K L K+ +LE +Q E + + EK LK+I ++ R
Sbjct: 1809 K-SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEI---FMQVEDERRH 1864
Query: 326 LTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKR 385
KE++ + ++QL LEE + E + +K + +D E N+ L R
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEA-----NEGLSR 1919
Query: 386 KAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSD 445
+ V+ L+ NR+ + I+ + + L+ + ++ S ++ TSD
Sbjct: 1920 E-------VSTLK------NRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSD 1966
Query: 446 IQRLQ 450
+ Q
Sbjct: 1967 VNETQ 1971
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 90.9 bits (224), Expect = 3e-18
Identities = 127/618 (20%), Positives = 250/618 (40%), Gaps = 132/618 (21%)
Query: 75 QGLTGMKTGTKGP-QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLS-- 131
+ L + T +KG +++ + K L L++++SE T +V +L +E+ +E ++L+
Sbjct: 806 ESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQL 865
Query: 132 ------YEKRAETLAVEIKELQGQLADYN----------------------MLVDKLNTN 163
+EK+ + + E+ LQ +L N ML + N
Sbjct: 866 EGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
Query: 164 TEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATD----DII 219
E+E+ ++ ++E Q +R++ +++R +EE+ E D +I
Sbjct: 926 GELEDTQTKLEKQVSKLEQELQK------QRESSAEKLRKMEEKCESAAHEADLKRQKVI 979
Query: 220 KNMSFENQVKYLEMKTTNEKL--------------------LQELDTLQQQLDSQNMKK- 258
+ QVK +EM E+L L +LD + Q ++ KK
Sbjct: 980 ELTGTARQVK-IEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038
Query: 259 ----------ESLEAEIAHSQVKQEAVL---------LHEKLYELESHRD-----QMIAE 294
S E E+ + K+E + L L +L+ RD Q+ E
Sbjct: 1039 NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 295 DK--SIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQG 352
+K +I E + +I+D QE+ M++ L + ++ Q ++ LDM + EH+G
Sbjct: 1099 EKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRG 1158
Query: 353 EMNQK--------------YKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLE 398
EM QK KE K+ E ++ ++ +E ++ Q E I L +
Sbjct: 1159 EMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKK 1218
Query: 399 HCSRNINRIEQISSI-----------------TNQELKMMQDDLNFKSTEVQKSQSTAQN 441
R R++++ S+ QEL++ ++ + TE+ +++
Sbjct: 1219 EIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQ 1278
Query: 442 LTSDIQRLQLDLQKMELLESKMTEEQHSL-----KSKIKQMTTDLEIYNDLPALKSSGEE 496
+I+RL +L+ M+ L + + L SK+++ + + ++ L S+ E
Sbjct: 1279 AQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKL-SAEVE 1337
Query: 497 KIKKLHQERMILSTHRNAFKKI------MEKQNIEYEALKTQLQENETHSQLTNLERKWQ 550
+K+ + MI +A KI Q + + K +L+ E ++NL ++ Q
Sbjct: 1338 SLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQ 1397
Query: 551 HLEQNNFAMKEFIATKSQ 568
+ A E + TK +
Sbjct: 1398 DRNEVIEAANEALLTKGE 1415
Score = 70.9 bits (172), Expect = 3e-12
Identities = 111/534 (20%), Positives = 241/534 (45%), Gaps = 69/534 (12%)
Query: 107 ELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEM 166
E+ ++ +L+ +E +Q+ + EK L +I Q L + L+ + +
Sbjct: 765 EMEKQIERLEAQLEKKDQQ---FKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKK 821
Query: 167 EEVMNDYNMLKAQND--RET-------QSLDVIFTERQAKEKQIRSVEEEIEQEKQATDD 217
E + D + QN ET +L++ E Q+ +E+ E++ + +
Sbjct: 822 ENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSE 881
Query: 218 IIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESL---EAEIAHSQVKQEA 274
+ + E ++K ++ T+E+ + TLQQQ Q +++E++ E E ++++++
Sbjct: 882 EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ--QQMLQQETIRNGELEDTQTKLEKQV 939
Query: 275 VLLHEKLY-ELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKI 333
L ++L + ES +++ ++ S E + +++ + ++ ++ KE++
Sbjct: 940 SKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEEL 999
Query: 334 NQFIEEI--------------RQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETK 379
++ +EI QLDM L++ + E+ +K +K+ E+ ++ ET+
Sbjct: 1000 SKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEK-----LQHSTETE 1054
Query: 380 NQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTA 439
E +K ++ LE +N + ++ S T ++L+ ++D L +++ +T
Sbjct: 1055 LTEALQKREV-------LETELQNAH--GELKS-TLRQLQELRDVLQKAQLSLEEKYTTI 1104
Query: 440 QNLTSDIQRLQLDLQ--KMELLE--SKMTEEQHSLKSKIKQMT-TDLEIYNDLPALKSSG 494
++LT++++ +++++ K ELLE + E LK + Q+T D+ I +
Sbjct: 1105 KDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREH----RGEM 1160
Query: 495 EEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENE--------THSQL-TNL 545
E+KI KL K +E N + + K QL+E E SQL +
Sbjct: 1161 EQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEI 1220
Query: 546 ERKWQHLEQNNFAMKE---FIATKSQES-DYQPIKKNVTKQIAEYNKTIVDALH 595
ER Q +++ MKE +IAT+ +E+ D + +Q+ + + +A H
Sbjct: 1221 ERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARH 1274
Score = 68.6 bits (166), Expect = 2e-11
Identities = 81/475 (17%), Positives = 201/475 (42%), Gaps = 83/475 (17%)
Query: 143 IKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTE--------- 193
I EL+ +LA + KL+ N ++ +++ + +E+ L + TE
Sbjct: 559 ISELRIKLAIKEAEIQKLHANLTANQLSQ--SLITCNDSQESSKLSSLETEPVKLGGHQV 616
Query: 194 -RQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLD 252
K++ ++ ++ E+E+Q I+ + + K ++++ N L +++ +
Sbjct: 617 AESVKDQNQHTMNKQYEKERQRLVTGIEEL----RTKLIQIEAENSDL--KVNMAHRTSQ 670
Query: 253 SQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQI 312
Q +++E LE S+++ E +L LE ++ I SI + E E+ ++
Sbjct: 671 FQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQ---EL 727
Query: 313 KDDNQEIASMERQLTDTKEKINQFIEEIRQL----------------------DMDLEEH 350
+ N++I S+E + EKI E+ +++ D +E
Sbjct: 728 MEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQ 787
Query: 351 QGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQI 410
+ M+ +++ ++ H+++ E+K + K + + + AL S ++ Q+
Sbjct: 788 EKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQL 847
Query: 411 SSI----------------------------TNQELKMMQDDLNFKSTEVQKSQSTAQNL 442
S ++E+ +Q +L K+ +Q++ L
Sbjct: 848 DSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVIL 907
Query: 443 TSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLH 502
+Q+ Q LQ+ + ++ + Q L+ ++ ++ +L+ + S EK++K+
Sbjct: 908 QHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQ------KQRESSAEKLRKM- 960
Query: 503 QERMILSTHRNAFK--KIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQN 555
+E+ + H K K++E + A + +++ ++ +L+ +E++ HL+++
Sbjct: 961 EEKCESAAHEADLKRQKVIE---LTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 1012
Score = 65.1 bits (157), Expect = 2e-10
Identities = 106/562 (18%), Positives = 238/562 (42%), Gaps = 92/562 (16%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L+ + +E+ L++ + +EN+ + +++ +AV+ E+ QL + + KL
Sbjct: 405 LQERCGLYKSELEILKEKLRQLKEENN---NGKEKLRIMAVKNSEVMAQLTESRQSILKL 461
Query: 161 NTNTEMEE--------VMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEK 212
+ E ++ +MN+ LK + + + LD+ E ++ ++RS+E+ I Q
Sbjct: 462 ESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLP 521
Query: 213 QATD--------DIIKNMSFEN-QVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEA 263
+ + SF N + + + N+ ++ E L+ +L + + + L A
Sbjct: 522 LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE---LRIKLAIKEAEIQKLHA 578
Query: 264 EIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASME 323
+ +Q+ Q + ++ + S + E +G ++ + +KD NQ +M
Sbjct: 579 NLTANQLSQSLITCNDS--QESSKLSSLETEPVKLGG-----HQVAESVKDQNQH--TMN 629
Query: 324 RQLTDTKEKINQFIEEIRQ--LDMDLEEHQGEMNQKYK---------ELKKREEHMDTFI 372
+Q ++++ IEE+R + ++ E ++N ++ EL ++ +
Sbjct: 630 KQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE 689
Query: 373 ETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEV 432
+ +Q L + Q+E IVA ++N +EQ N++++ ++ ++N + ++
Sbjct: 690 SEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNA-ELEQELMEKNEKIRSLETNINTEHEKI 748
Query: 433 QKSQSTA--------QNLTSDIQRLQLDLQK-----------MELLESKMTEEQHSLKSK 473
+ A + + I+RL+ L+K M +L+ + +QH L+S
Sbjct: 749 CLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESL 808
Query: 474 IKQMT--------TDLEIYNDLPALKSSGEEKIKKLHQ---------ERMI-----LSTH 511
+ +T +++ L AL++ E+ K+ Q E ++ L +
Sbjct: 809 DRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN 868
Query: 512 RNAFKKIMEKQNIEYEALKTQLQ-----ENETHSQLTNLERKWQHLEQNNFAMKEFIATK 566
+ F+K ++K++ E L+ +L+ ET Q L+ Q +Q +E I
Sbjct: 869 KEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQ--QQQQMLQQETIRNG 926
Query: 567 SQESDYQPIKKNVTKQIAEYNK 588
E ++K V+K E K
Sbjct: 927 ELEDTQTKLEKQVSKLEQELQK 948
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 90.9 bits (224), Expect = 3e-18
Identities = 95/515 (18%), Positives = 224/515 (43%), Gaps = 50/515 (9%)
Query: 98 LGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEI-KELQGQLADYNML 156
L L ++ LT ++ K++ + + +E S + + E VE +EL N
Sbjct: 739 LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQE 798
Query: 157 VDKL-NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQAT 215
+K N +T E++ + Q +E + + Q E ++R+V+ + Q Q
Sbjct: 799 EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQER 858
Query: 216 DDIIKNMSFENQVKYLE--MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH--SQVK 271
+D + +S E + L+ + T + +E++ Q++++S+N E +++H S ++
Sbjct: 859 NDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQ 918
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKE 331
+E +L E+++ ++Q ++K LK +K+ N+++ ++ + +E
Sbjct: 919 EEIAMLR---LEIDTIKNQNQEKEKKCFED-------LKIVKEKNEDL---QKTIKQNEE 965
Query: 332 KINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEET-------KNQELK 384
+ Q I + L +N K + K+ +E ++ +E++ ++Q
Sbjct: 966 TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 1025
Query: 385 RKAQIEANIVALLEHCSR-------NINRIEQISSITNQELKMMQDDLNFKSTEVQKSQS 437
K ++E + CSR +++ ++ + I +Q+L + LN E ++
Sbjct: 1026 SKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRD 1085
Query: 438 TAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEK 497
+ T ++R+Q DL + + +M ++ + + K+ N + S EE+
Sbjct: 1086 ALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKV----------NKYIGKQESVEER 1135
Query: 498 IKKLHQERMIL-----STHRNAFKKIMEKQNI--EYEALKTQLQENETHSQLTNLERKWQ 550
+ +L E M+L H A K NI ++ A+ +LQ L ER +
Sbjct: 1136 LSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKE 1195
Query: 551 HLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAE 585
+ + N + ++++++ + + + + +++A+
Sbjct: 1196 LISECNHLKERQYQYENEKAEREVVVRQLQQELAD 1230
Score = 58.2 bits (139), Expect = 2e-08
Identities = 106/527 (20%), Positives = 225/527 (42%), Gaps = 115/527 (21%)
Query: 100 LLRSKISELTTEVNKLQKGIEMYNQENSVY---LSYEKRAETLA---VEIKELQGQLADY 153
+L ++ + +++N L+ IE ++ +++ L E+ + L+ ++KE++ + +
Sbjct: 1061 ILSQQLFKTESKLNSLE--IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1118
Query: 154 NMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQ 213
+ V+K + E V + L+++N Q LD + KEK + +++++
Sbjct: 1119 QVKVNKYIG--KQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHA--- 1173
Query: 214 ATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQ-QLDSQNMKKE------SLEAEIA 266
I++ + E++ + L ++ N++L+ E + L++ Q +N K E L+ E+A
Sbjct: 1174 ----IVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELA 1229
Query: 267 HSQVKQ---EAVL---------LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKD 314
+ KQ EA L L ++ +L+ Q+ + + E + ++++D
Sbjct: 1230 DTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQD 1289
Query: 315 DNQEIASMERQLTDTKEKINQFIEEIRQ--LDMDLEEHQGEMNQKYKELKKREEHMDTFI 372
Q++ +L T +K IEE+++ L+ +L E + E +K ELK
Sbjct: 1290 HKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELK---------- 1339
Query: 373 ETFEETKNQELKRKAQIEANIVA---LLEHCSRNINRIEQISSITNQELKMMQ------- 422
++ E +QE+K+ ++E I LL+ + +N E + +LK Q
Sbjct: 1340 QSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQI 1399
Query: 423 -------DDLNF-------------------------------KSTEVQKSQSTAQ---- 440
DDL K ++QK++ +
Sbjct: 1400 NKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVI 1459
Query: 441 NLTSDIQRLQLDLQKMELLESKMTEE-QHSLKSKIKQMTTDLEIY------------NDL 487
NL S I+R ++L +++ + ++ E + + K+K++ L+ N+
Sbjct: 1460 NLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNF 1519
Query: 488 PALKSSGEEKIKKLHQERMILSTHRNAFKKI-MEK-QNIEYEALKTQ 532
++KS E +IK L E + T + F K +EK + + E LK +
Sbjct: 1520 ASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVR 1566
Score = 55.5 bits (132), Expect = 1e-07
Identities = 66/353 (18%), Positives = 149/353 (42%), Gaps = 18/353 (5%)
Query: 142 EIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQI 201
+I+ELQ L + N+ D+ ++ E+ Q ++ L+ T + K
Sbjct: 1311 KIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1370
Query: 202 RSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESL 261
R E E + + +K FE ++ ++K + L EL+T + + K + L
Sbjct: 1371 RKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQIL 1430
Query: 262 EAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIAS 321
+ E+ + Q +K +L+ ++ ++ E ++ S +E L Q+K QEI
Sbjct: 1431 QEELLSMKTVQ------KKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1484
Query: 322 MERQ-LTDTKEKINQFIEEIRQLDMDLEEH--------QGEMNQKYKELKKREEHMDTFI 372
RQ + + +++N F++ +LE+ + +M + K+L+ + T
Sbjct: 1485 RARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQ 1544
Query: 373 ETFEETKNQELKRKAQIEANI-VALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTE 431
E F +T+ ++ K+ E + +L ++ R+ ++++ E + + +T
Sbjct: 1545 EDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTR 1604
Query: 432 VQKSQSTAQNLTS--DIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLE 482
NL + D+ R + + + + S +S+++ + +M +LE
Sbjct: 1605 PVMEPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELE 1657
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 89.7 bits (221), Expect = 7e-18
Identities = 113/529 (21%), Positives = 224/529 (42%), Gaps = 51/529 (9%)
Query: 101 LRSKISELTTEVNKLQKGIE------MYNQENSVYLSYEKRAETLAVEIKELQGQLADYN 154
LRS+ +E E + LQ+ +E N E + E+ E EI++LQ QL++ +
Sbjct: 654 LRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER--EQHQTEIRDLQDQLSEMH 711
Query: 155 MLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQA 214
+D + + E+ +L+A+ D L + ++ +E +R E E+ K A
Sbjct: 712 DELDSAKRSEDREKGALIEELLQAKQD-----LQDLLIAKEEQEDLLRKRERELTALKGA 766
Query: 215 TDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEA 274
+ + +S +Q EM E+ EL L++ ++ E L + S+ Q
Sbjct: 767 ---LKEEVSSHDQ----EMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAG 819
Query: 275 VLLHEKLYELESHRDQMIAED---------KSIGSPMEEREKLLKQIKDDNQEIASMERQ 325
+ KL + E+ + Q +E+ + I + K + +K EI +E
Sbjct: 820 TEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEA 879
Query: 326 LTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE-------LKKREEHMDTFIETFEET 378
L +++ + + R L+ +LE QG ++Q +E LK+ E + E
Sbjct: 880 LVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEM 939
Query: 379 KNQELKRKAQIE------ANIVALLEHCSRNI-NRIEQISSITNQELKMMQDDLNFKSTE 431
+N+ IE A+IV + + N++++ +EL MQ L K+ E
Sbjct: 940 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 432 VQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLE----IYNDL 487
+KS+ TA + +++ ++ +L+ + + + ++ L+ +K + +LE + +D
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 488 PALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLER 547
L E+K+ +L E + + + + + + E L+ +L + Q +LE
Sbjct: 1060 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQ--DLEC 1117
Query: 548 KWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHS 596
LE+ N +K I E Y+ K+ + Q+ + D L S
Sbjct: 1118 DKISLERQNKDLKSRII--HLEGSYRSSKEGLVVQMEARIAELEDRLES 1164
Score = 69.3 bits (168), Expect = 9e-12
Identities = 87/444 (19%), Positives = 199/444 (44%), Gaps = 45/444 (10%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLV-DK 159
L+ + EL V +LQ+ IE + + K+ E EI++L+ L +
Sbjct: 834 LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG---EIRQLEEALVHARKEEKEA 890
Query: 160 LNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDII 219
++ +E + +Q +E + L E +++Q+R ++ E+E E+ I
Sbjct: 891 VSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
Query: 220 KNMSFE-------NQVKYLEMKTT----NEKLLQELDTLQQQLDSQNMKKESLEAEIAHS 268
+ + E ++ LE++ EK +EL +Q+QL + ++ E ++ +
Sbjct: 951 EKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAE--KSRLTAM 1008
Query: 269 QVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTD 328
+++ E L+ E+L RD A+D+++ +R+ L + +KD E+ + D
Sbjct: 1009 KMQDEMRLMEEEL------RDYQRAQDEAL----TKRQLLEQTLKDLEYELEAKSHLKDD 1058
Query: 329 TKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKA- 387
+ Q +++ QL+M+LEE + + + + + E M E+ +N+ L+ +A
Sbjct: 1059 RSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM-------EQLRNELLQERAA 1111
Query: 388 --QIEANIVALLEHCSRNINRIEQI--SSITNQELKMMQDDLNFKSTE--VQKSQSTAQN 441
+E + ++L +RI + S +++E ++Q + E ++ + N
Sbjct: 1112 RQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRAN 1171
Query: 442 LTSDIQRLQLDLQKMELL----ESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEK 497
L +RL+ ++++ + +T+++ L ++K M +E + S ++K
Sbjct: 1172 LQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKK 1231
Query: 498 IKKLHQERMILSTHRNAFKKIMEK 521
+++ +E+M ++ H M+K
Sbjct: 1232 LQRELEEQMDMNEHLQGQLNSMKK 1255
Score = 63.9 bits (154), Expect = 4e-10
Identities = 109/572 (19%), Positives = 228/572 (39%), Gaps = 106/572 (18%)
Query: 68 AHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENS 127
AH Q + G T+G Q + ++ LG K E+ T L Q +
Sbjct: 457 AHSRPPQPNIDGKVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLML------QNRA 510
Query: 128 VYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMND-------YNMLKA-- 178
S + A+ ++V+ ++ D L E+ + N+ YN LK
Sbjct: 511 TATSPDSGAKKISVKTFP---SASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGS 567
Query: 179 --QNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTT 236
+D + ++++F + Q + + + Q +T ++ K++ LE K+
Sbjct: 568 TDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEV-KDL--------LEQKS- 617
Query: 237 NEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQ-VKQEAVLLHEKLYELESHRDQMIAED 295
KL E+ LQ+QL + E+ + Q +K+E + L EL S ++ + E+
Sbjct: 618 --KLTIEVAELQRQL----------QLEVKNQQNIKEERERMRANLEELRSQHNEKVEEN 665
Query: 296 KSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMN 355
++ +EE E L++ +EE+ Q+ M+ E+HQ E+
Sbjct: 666 STLQQRLEESEGELRKN------------------------LEELFQVKMEREQHQTEIR 701
Query: 356 QKYKELKKREEHMDT-----------FIETF--------------EETKNQELKRKAQIE 390
+L + + +D+ IE EE ++ KR+ ++
Sbjct: 702 DLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELT 761
Query: 391 ANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQ 450
A AL E S + ++++ + EL+ +++ + + V+ S + D +
Sbjct: 762 ALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTE 821
Query: 451 LDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILST 510
+ ++ ++ K+ L+ ++ Q+ +E DL ++ +E +KK E
Sbjct: 822 MRVKLLQEENEKLQGRSEELERRVAQLQRQIE---DLKGDEAKAKETLKKYEGE------ 872
Query: 511 HRNAFKKIMEKQNIEYEALKT-QLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQ- 568
R + ++ + E EA+ + ENE + NL + Q +Q + +KE K Q
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL 932
Query: 569 ---ESDYQPIKKNVTKQIAEYNKTIVDALHST 597
+++ + + ++ K I + K + D + ++
Sbjct: 933 RRLKNEMENERWHLGKTIEKLQKEMADIVEAS 964
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/289 (20%), Positives = 136/289 (47%), Gaps = 28/289 (9%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
QRQ+ +K+ R ++ E+ +++ + Y + L+ + + L +K+L+
Sbjct: 990 QRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALT---KRQLLEQTLKDLE 1046
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
+L + L D + + ++++ + + L+ + + E + D++ +Q+ + E
Sbjct: 1047 YELEAKSHLKD--DRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNE 1104
Query: 208 IEQEKQATDDII--------KNMSFENQVKYLE--MKTTNEKLLQELDTLQQQLDSQNMK 257
+ QE+ A D+ +N ++++ +LE +++ E L+ +++ +L+ +
Sbjct: 1105 LLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELED---R 1161
Query: 258 KESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQ 317
ES E + A+ Q+ L K+ EL D E S+ ++ LK +K +
Sbjct: 1162 LESEERDRANLQLSNRR--LERKVKELVMQVDD---EHLSLTDQKDQLSLRLKAMKRQVE 1216
Query: 318 EIASMERQLTDTKEKINQFIEEIRQLDMDLEEH-QGEMNQKYKELKKRE 365
E +L +K+K+ + +EE MD+ EH QG++N K+L+ ++
Sbjct: 1217 EAEEEIDRLESSKKKLQRELEE----QMDMNEHLQGQLNSMKKDLRLKK 1261
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 89.0 bits (219), Expect = 1e-17
Identities = 94/444 (21%), Positives = 198/444 (44%), Gaps = 40/444 (9%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L + LT V +L+ ++ S L EK + L+ +++ L+ ++
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ-------- 516
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIK 220
E + + N N+ K + Q I T R+ E+QI+ +E+E E Q + +
Sbjct: 517 ----EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ 572
Query: 221 NMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQE-AVLLHE 279
+ + +++ N+ L + + +L +K ++ E+ H + K E A L
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 280 KLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEE 339
+L+ LE + + + ++ E+ E L QE + +ER+ K+ ++ F
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEAL-------EQENSELERENRKLKKTLDSFKNL 685
Query: 340 IRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFE--ETKNQELKRKAQIEANIVALL 397
QL+ LE+ +++++ EL++ E + + +N+EL+ + + + LL
Sbjct: 686 TFQLE-SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744
Query: 398 EHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKME 457
+ + R+E + E + +Q L + ++Q+ +S Q+L + Q LQ +L++++
Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
Query: 458 LLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKK 517
+ SK E+ ++Q T+ LE K E++ K+L Q+ I T
Sbjct: 805 -ISSKRLEQLEKENKSLEQETSQLE------KDKKQLEKENKRLRQQAEIKDT------- 850
Query: 518 IMEKQNIEYEALKTQLQENETHSQ 541
+E+ N++ L+ +EN+T S+
Sbjct: 851 TLEENNVKIGNLE---KENKTLSK 871
Score = 85.1 bits (209), Expect = 2e-16
Identities = 114/526 (21%), Positives = 240/526 (45%), Gaps = 93/526 (17%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNT 162
SK+S++ E +++K +E Y ++ +RAE L E+ L+ + N L+ K T
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKG-------ERAEELENELHHLEKE----NELLQKKIT 649
Query: 163 NTEME-EVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
N ++ E + ++ +RE + L + Q+ S+E+E Q + ++ +N
Sbjct: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRN 709
Query: 222 MSFEN--QVKYLEMKTTNEKLLQELDTLQQQLD---SQNMKKESLEA-----EIAHSQVK 271
+ +K +++ N++L E + L++ L+ + K E LE +I + +++
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEERE---KLLKQIKDDNQEIASMERQLTD 328
+ ++K+ +LES + E++++ +EE + K L+Q++ +N+ + QL
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Query: 329 TKEKINQFIEEIRQL----DMDLEEHQGEMNQKYKELKKREEHMDTFIETFE-----ETK 379
K+++ + + +RQ D LEE+ ++ KE K + + + E+ E +
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
Query: 380 NQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELK--MMQDDLNFKSTEVQKSQS 437
N+EL ++A I+ + L + +++LK M +DL + E++K
Sbjct: 890 NKELVKRATIDIKTLVTLRE------------DLVSEKLKTQQMNNDLEKLTHELEKIGL 937
Query: 438 TAQNLTSDIQRLQLDLQKMELLESKMT-----------EEQHSLKSKIKQMTT-DLEIYN 485
+ L D Q D + +LLESK+ E+ +L++++++ T + ++
Sbjct: 938 NKERLLHDEQ--STDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 995
Query: 486 DLPALKSSGEEKIKKLHQERMILS-----------------THRNAFK---KIMEKQN-- 523
+L +K + E ++ +ERM+ S T R K +++E +
Sbjct: 996 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 524 ----IEYEALKTQL-----QENETHSQLTNLERKWQHLEQNNFAMK 560
E +ALKTQL Q N +Q+ L+R+ L++ N ++
Sbjct: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ 1101
Score = 82.8 bits (203), Expect = 8e-16
Identities = 114/523 (21%), Positives = 228/523 (43%), Gaps = 60/523 (11%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
+RQI + + + EL E++ L+K E+ ++ + ++ E L E EL+
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE 669
Query: 148 GQLADYNMLVDKL-NTNTEMEEVMNDYNMLKAQN---DRETQSLDVIFTERQAKEKQIRS 203
+ +D N ++E + + + L +N R +SL + + + +
Sbjct: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 204 VEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEA 263
+E E EQ K+ + + SF+ K ++ + + L E LQ+ L++ N K + LE+
Sbjct: 730 LESEKEQLKKGLE--LLKASFK---KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 264 EIAHSQVKQEAVLLHEKLYELESHR-DQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASM 322
E+ +++ + + + + ++ S R +Q+ E+KS+ + EK KQ++ +N+ +
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQE 382
T E+ N I + + + L + G + LK+ E+ +N+E
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK------------ENKE 892
Query: 383 LKRKAQIEANIVALLEHCSRNINRIEQISSITNQELK--MMQDDLNFKSTEVQKSQSTAQ 440
L ++A I+ + L + +++LK M +DL + E++K +
Sbjct: 893 LVKRATIDIKTLVTLR------------EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Query: 441 NLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYND-LPALKSSGEEKIK 499
L D Q D + +LLESK L+S +K+ LEI + + AL++ EE
Sbjct: 941 RLLHDEQ--STDDSRYKLLESK-------LESTLKK---SLEIKEEKIAALEARLEESTN 988
Query: 500 KLHQERMILSTHRNAFKKIMEKQN----------IEYEALKTQLQENETHSQLTNLERKW 549
Q R L T + ++ + ++Q+ I E K + + ET +L ++ +
Sbjct: 989 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1048
Query: 550 QHLEQNNFAMK-EFIATKSQESDYQPIKKNVTKQIAEYNKTIV 591
+E+NN ++ E A K+Q + N+ QI + V
Sbjct: 1049 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091
Score = 73.9 bits (180), Expect = 4e-13
Identities = 101/477 (21%), Positives = 204/477 (42%), Gaps = 50/477 (10%)
Query: 101 LRSKISELTTEVNKLQKGIEMY-----NQENSVYLSYEKRAETL---AVEIKE-----LQ 147
+ + + +LT E+ K+ E + ++S Y E + E+ ++EIKE L+
Sbjct: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE 980
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRE--TQSLDVIFTERQAKEKQIRSVE 205
+L + +L E++ V +Y LK + D E QS I E E++ +
Sbjct: 981 ARLEESTNYNQQLRQ--ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETT 1038
Query: 206 EEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEI 265
E+ + K + +E++ N L E L+ QL + +L+A+I
Sbjct: 1039 RELLKVKD---------------RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083
Query: 266 AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSP----MEEREKLLKQIKDDNQEIAS 321
Q ++ V L E+ L++ ++ E+ ++ S M + +LL Q E S
Sbjct: 1084 LALQ--RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES 1141
Query: 322 MERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQ---KYKELKKREEHMDTFIETFEET 378
+ ++ D K + I++ +L++ E E K+ LK ++++ E+
Sbjct: 1142 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1201
Query: 379 KNQELKRKAQIE--ANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKS- 435
NQ LK+K Q+E ++ + + N+ + + ++L D LN +++ K
Sbjct: 1202 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1261
Query: 436 ---QSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKS 492
Q+ +NL S + +L+ ++E SK+ E+ L ++ E+ + L +
Sbjct: 1262 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG--N 1319
Query: 493 SGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQE-NETHSQLTNLERK 548
EE L Q + ++ +R ++ ME +++ + + + + NE Q LE K
Sbjct: 1320 LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
Score = 73.6 bits (179), Expect = 5e-13
Identities = 94/537 (17%), Positives = 224/537 (41%), Gaps = 62/537 (11%)
Query: 77 LTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQ----------KGIEMYNQEN 126
L K + ++++ +K+ L + ++ ++ E+ +LQ + MY E
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 127 SVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQS 186
R + L E+ + +L D ++ E +V+ + + T++
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 187 LDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ---E 243
E + + Q+++ ++E E+ I+ + EN + K + ++ L E
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432
Query: 244 LDTLQQQLDSQNMKKESLEAEIAHS------QVKQEAVLLHEKLYELESHRDQMIAEDKS 297
L+ + + + ++SL E+ +++ E L + + EL + D +
Sbjct: 433 LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASK 492
Query: 298 IGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQK 357
I +E ++L K+++ EI ++ L + + ++E QL+ +E + ++
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 358 YKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQE 417
K L++ EH++ + + L++++QI A R++ I +E
Sbjct: 553 IKILEQENEHLNQTVSS--------LRQRSQISAEA------------RVKDI----EKE 588
Query: 418 LKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESK---MTEEQHSLKSKI 474
K++ + + S+++ K + + + +++ + ++ E LE++ + +E L+ KI
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648
Query: 475 KQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEK-QNIEYEALKTQL 533
T+L+I EKI+ L QE L KK ++ +N+ ++ +
Sbjct: 649 ----TNLKITC----------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK 694
Query: 534 QENETHSQLTNLERKWQHLEQNNFAMKEF-IATKSQESDYQPIKKNVTKQIAEYNKT 589
+ ++ + L R + L+ + M + + K ES+ + +KK + A + KT
Sbjct: 695 ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
Score = 45.1 bits (105), Expect = 2e-04
Identities = 85/423 (20%), Positives = 184/423 (43%), Gaps = 58/423 (13%)
Query: 210 QEKQATDDIIKNMSFENQVK---YLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIA 266
Q+K+ + I+ + F+ + +++ T N++ + +L Q ++ +M +E +E +
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDL----QWMEVTDMSQEDIEPLLK 191
Query: 267 HSQVKQEAVLLH-----EKLYELESHRDQM-------IAEDKSIGSPMEEREKLLKQIKD 314
+ + + ++ E + EL RD + + GSP +R
Sbjct: 192 NMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT-------- 243
Query: 315 DNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKK-REEHMDTFIE 373
++++ S+E L D K KI + +E+ + L + + E+ Q ELK+ ++E+M+ +
Sbjct: 244 ESRQHLSVE--LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301
Query: 374 TFEETKNQE----LKRKA----QIEANIVAL------LEHCSRNINRIEQISSITNQELK 419
++ L+ KA ++E+ + +E + +++ + + +
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361
Query: 420 MMQDDL------NFKSTEVQKSQSTAQNLTSDIQ-RLQLDLQKM-ELLESKMTEEQHSLK 471
M++D L + K E++K + D++ +D +K+ EL+E MT E +
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 472 SKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNI--EYEAL 529
S + + E+ + E K L E L++ R K ME Q++ E L
Sbjct: 422 SMDESLHLGWEL-EQISRTSELSEAPQKSLGHEVNELTSSR-LLKLEMENQSLTKTVEEL 479
Query: 530 KTQLQENETH-SQLTNLERKWQHLEQN-NFAMKEFIATKSQESDYQPIKKNVTKQIAEYN 587
+T + E + S++ +E++ Q L + E + K + Q + K++ K+ A+
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 588 KTI 590
KTI
Sbjct: 540 KTI 542
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 89.0 bits (219), Expect = 1e-17
Identities = 94/444 (21%), Positives = 198/444 (44%), Gaps = 40/444 (9%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L + LT V +L+ ++ S L EK + L+ +++ L+ ++
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ-------- 516
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIK 220
E + + N N+ K + Q I T R+ E+QI+ +E+E E Q + +
Sbjct: 517 ----EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ 572
Query: 221 NMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQE-AVLLHE 279
+ + +++ N+ L + + +L +K ++ E+ H + K E A L
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 280 KLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEE 339
+L+ LE + + + ++ E+ E L QE + +ER+ K+ ++ F
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEAL-------EQENSELERENRKLKKTLDSFKNL 685
Query: 340 IRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFE--ETKNQELKRKAQIEANIVALL 397
QL+ LE+ +++++ EL++ E + + +N+EL+ + + + LL
Sbjct: 686 TFQLE-SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744
Query: 398 EHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKME 457
+ + R+E + E + +Q L + ++Q+ +S Q+L + Q LQ +L++++
Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
Query: 458 LLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKK 517
+ SK E+ ++Q T+ LE K E++ K+L Q+ I T
Sbjct: 805 -ISSKRLEQLEKENKSLEQETSQLE------KDKKQLEKENKRLRQQAEIKDT------- 850
Query: 518 IMEKQNIEYEALKTQLQENETHSQ 541
+E+ N++ L+ +EN+T S+
Sbjct: 851 TLEENNVKIGNLE---KENKTLSK 871
Score = 83.6 bits (205), Expect = 5e-16
Identities = 113/526 (21%), Positives = 239/526 (45%), Gaps = 94/526 (17%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNT 162
SK+S++ E +++K +E Y ++ +RAE L E+ L+ + N L+ K T
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKG-------ERAEELENELHHLEKE----NELLQKKIT 649
Query: 163 NTEME-EVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
N ++ E + ++ +RE + L + Q+ S+E+E Q + ++ +N
Sbjct: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRN 709
Query: 222 MSFEN--QVKYLEMKTTNEKLLQELDTLQQQLD---SQNMKKESLEA-----EIAHSQVK 271
+ +K +++ N++L E + L++ L+ + K E LE +I + +++
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEERE---KLLKQIKDDNQEIASMERQLTD 328
+ ++K+ +LES + E++++ +EE + K L+Q++ +N+ + QL
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Query: 329 TKEKINQFIEEIRQL----DMDLEEHQGEMNQKYKELKKREEHMDTFIETFE-----ETK 379
K+++ + + +RQ D LEE+ ++ KE K + + + E+ E +
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
Query: 380 NQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELK--MMQDDLNFKSTEVQKSQS 437
N+EL ++A I+ + L + +++LK M +DL + E++K
Sbjct: 890 NKELVKRATIDIKTLVTLRE------------DLVSEKLKTQQMNNDLEKLTHELEKIGL 937
Query: 438 TAQNLTSDIQRLQLDLQKMELLESKMT-----------EEQHSLKSKIKQMTT-DLEIYN 485
+ L D Q + +LLESK+ E+ +L++++++ T + ++
Sbjct: 938 NKERLLHDEQSTD---DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 994
Query: 486 DLPALKSSGEEKIKKLHQERMILS-----------------THRNAFK---KIMEKQN-- 523
+L +K + E ++ +ERM+ S T R K +++E +
Sbjct: 995 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1054
Query: 524 ----IEYEALKTQL-----QENETHSQLTNLERKWQHLEQNNFAMK 560
E +ALKTQL Q N +Q+ L+R+ L++ N ++
Sbjct: 1055 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ 1100
Score = 82.0 bits (201), Expect = 1e-15
Identities = 105/522 (20%), Positives = 227/522 (43%), Gaps = 59/522 (11%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
+RQI + + + EL E++ L+K E+ ++ + ++ E L E EL+
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE 669
Query: 148 GQLADYNMLVDKL-NTNTEMEEVMNDYNMLKAQN---DRETQSLDVIFTERQAKEKQIRS 203
+ +D N ++E + + + L +N R +SL + + + +
Sbjct: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 204 VEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEA 263
+E E EQ K+ + + SF+ K ++ + + L E LQ+ L++ N K + LE+
Sbjct: 730 LESEKEQLKKGLE--LLKASFK---KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 264 EIAHSQVKQEAVLLHEKLYELESHR-DQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASM 322
E+ +++ + + + + ++ S R +Q+ E+KS+ + EK KQ++ +N+ +
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQE 382
T E+ N I + + + L + G + LK+ E+ +N+E
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK------------ENKE 892
Query: 383 LKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNL 442
L ++A I+ + L +++DL + + Q+ + + L
Sbjct: 893 LVKRATIDI------------------------KTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 443 TSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQ-MTTDLEIYND-LPALKSSGEEKIKK 500
T +++++ L+ +++ E + L+SK++ + LEI + + AL++ EE
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 988
Query: 501 LHQERMILSTHRNAFKKIMEKQN----------IEYEALKTQLQENETHSQLTNLERKWQ 550
Q R L T + ++ + ++Q+ I E K + + ET +L ++ +
Sbjct: 989 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048
Query: 551 HLEQNNFAMK-EFIATKSQESDYQPIKKNVTKQIAEYNKTIV 591
+E+NN ++ E A K+Q + N+ QI + V
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1090
Score = 73.6 bits (179), Expect = 5e-13
Identities = 94/537 (17%), Positives = 224/537 (41%), Gaps = 62/537 (11%)
Query: 77 LTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQ----------KGIEMYNQEN 126
L K + ++++ +K+ L + ++ ++ E+ +LQ + MY E
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 127 SVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQS 186
R + L E+ + +L D ++ E +V+ + + T++
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 187 LDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ---E 243
E + + Q+++ ++E E+ I+ + EN + K + ++ L E
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432
Query: 244 LDTLQQQLDSQNMKKESLEAEIAHS------QVKQEAVLLHEKLYELESHRDQMIAEDKS 297
L+ + + + ++SL E+ +++ E L + + EL + D +
Sbjct: 433 LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASK 492
Query: 298 IGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQK 357
I +E ++L K+++ EI ++ L + + ++E QL+ +E + ++
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 358 YKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQE 417
K L++ EH++ + + L++++QI A R++ I +E
Sbjct: 553 IKILEQENEHLNQTVSS--------LRQRSQISAEA------------RVKDI----EKE 588
Query: 418 LKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESK---MTEEQHSLKSKI 474
K++ + + S+++ K + + + +++ + ++ E LE++ + +E L+ KI
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648
Query: 475 KQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEK-QNIEYEALKTQL 533
T+L+I EKI+ L QE L KK ++ +N+ ++ +
Sbjct: 649 ----TNLKITC----------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK 694
Query: 534 QENETHSQLTNLERKWQHLEQNNFAMKEF-IATKSQESDYQPIKKNVTKQIAEYNKT 589
+ ++ + L R + L+ + M + + K ES+ + +KK + A + KT
Sbjct: 695 ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
Score = 73.6 bits (179), Expect = 5e-13
Identities = 102/476 (21%), Positives = 204/476 (42%), Gaps = 49/476 (10%)
Query: 101 LRSKISELTTEVNKLQKGIE-MYNQENSV---YLSYEKRAETL---AVEIKE-----LQG 148
+ + + +LT E+ K+ E + + E S Y E + E+ ++EIKE L+
Sbjct: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
Query: 149 QLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRE--TQSLDVIFTERQAKEKQIRSVEE 206
+L + +L E++ V +Y LK + D E QS I E E++ +
Sbjct: 981 RLEESTNYNQQLRQ--ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTR 1038
Query: 207 EIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIA 266
E+ + K + +E++ N L E L+ QL + +L+A+I
Sbjct: 1039 ELLKVKD---------------RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1083
Query: 267 HSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSP----MEEREKLLKQIKDDNQEIASM 322
Q ++ V L E+ L++ ++ E+ ++ S M + +LL Q E S+
Sbjct: 1084 ALQ--RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1141
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQ---KYKELKKREEHMDTFIETFEETK 379
++ D K + I++ +L++ E E K+ LK ++++ E+
Sbjct: 1142 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRY 1201
Query: 380 NQELKRKAQIE--ANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKS-- 435
NQ LK+K Q+E ++ + + N+ + + ++L D LN +++ K
Sbjct: 1202 NQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE 1261
Query: 436 --QSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSS 493
Q+ +NL S + +L+ ++E SK+ E+ L ++ E+ + L +
Sbjct: 1262 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG--NL 1319
Query: 494 GEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQE-NETHSQLTNLERK 548
EE L Q + ++ +R ++ ME +++ + + + + NE Q LE K
Sbjct: 1320 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
Score = 45.1 bits (105), Expect = 2e-04
Identities = 85/423 (20%), Positives = 184/423 (43%), Gaps = 58/423 (13%)
Query: 210 QEKQATDDIIKNMSFENQVK---YLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIA 266
Q+K+ + I+ + F+ + +++ T N++ + +L Q ++ +M +E +E +
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDL----QWMEVTDMSQEDIEPLLK 191
Query: 267 HSQVKQEAVLLH-----EKLYELESHRDQM-------IAEDKSIGSPMEEREKLLKQIKD 314
+ + + ++ E + EL RD + + GSP +R
Sbjct: 192 NMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT-------- 243
Query: 315 DNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKK-REEHMDTFIE 373
++++ S+E L D K KI + +E+ + L + + E+ Q ELK+ ++E+M+ +
Sbjct: 244 ESRQHLSVE--LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301
Query: 374 TFEETKNQE----LKRKA----QIEANIVAL------LEHCSRNINRIEQISSITNQELK 419
++ L+ KA ++E+ + +E + +++ + + +
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361
Query: 420 MMQDDL------NFKSTEVQKSQSTAQNLTSDIQ-RLQLDLQKM-ELLESKMTEEQHSLK 471
M++D L + K E++K + D++ +D +K+ EL+E MT E +
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 472 SKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNI--EYEAL 529
S + + E+ + E K L E L++ R K ME Q++ E L
Sbjct: 422 SMDESLHLGWEL-EQISRTSELSEAPQKSLGHEVNELTSSR-LLKLEMENQSLTKTVEEL 479
Query: 530 KTQLQENETH-SQLTNLERKWQHLEQN-NFAMKEFIATKSQESDYQPIKKNVTKQIAEYN 587
+T + E + S++ +E++ Q L + E + K + Q + K++ K+ A+
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 588 KTI 590
KTI
Sbjct: 540 KTI 542
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 88.6 bits (218), Expect = 2e-17
Identities = 117/579 (20%), Positives = 244/579 (42%), Gaps = 100/579 (17%)
Query: 98 LGLLRSKISELTTEVNKL----QKGIE-MYNQENSVYLSYEKRAETLAVE----IKELQG 148
LG ++ +EL T++ K+ Q IE + NQ++S ++ K E L + IKE +
Sbjct: 603 LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN 662
Query: 149 QLADYNMLVDKLNTN--TEMEEVMN----------DYNMLKAQNDRETQSLDVIFTERQA 196
L +DK EME+ +N + +L+A+ + +T+ +D ++ +A
Sbjct: 663 SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 722
Query: 197 KEKQI-------------RSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ- 242
E+++ +S +++ Q+ +A + IK++ E + + + +L
Sbjct: 723 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 782
Query: 243 --ELDTLQQQLDSQNMKKESLEAEIA-----HSQVKQEAVLLHEKLYELESHRDQMIAED 295
+L LQ+ L + KE+LE E+ ++ +EAV + + E + Q +
Sbjct: 783 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 842
Query: 296 KSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMN 355
+ S +E+ + L ++ +E E QL KEK+ I EI ++ D +MN
Sbjct: 843 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 902
Query: 356 QKYK-----------ELKKREEHMDTFIETFE-----------------ETKNQELKRK- 386
+ + +L K E+ ++ E E + +EL+RK
Sbjct: 903 DELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKL 962
Query: 387 AQIEANIVALLEHCSRNINRIEQISSITNQE----LKMMQDDLNFKSTEVQKSQSTAQNL 442
+ +E + C R E+ +S T + L+ +Q L +++ ++ L
Sbjct: 963 SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1022
Query: 443 TSDIQRLQLDLQK----------MELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKS 492
+++ L+ K M+++E E+ +L S T+ ++ N+L LK
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082
Query: 493 SGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHL 552
+ + +++L++ + +L+ ME+ E E LK + QL+ L+
Sbjct: 1083 NNLKNVEELNKSKELLTVENQK----MEEFRKEIETLKQAAAQKS--QQLSALQ------ 1130
Query: 553 EQNNFAMKEFIATKSQESDYQPIKKN---VTKQIAEYNK 588
E+N +E ++ + + +Q +++ + Q+ E K
Sbjct: 1131 EENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1169
Score = 55.5 bits (132), Expect = 1e-07
Identities = 97/415 (23%), Positives = 178/415 (42%), Gaps = 84/415 (20%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L+ K+++ + LQK IE + S ++ A+ E KEL+ +L+D ++
Sbjct: 915 LQLKLTKANENASFLQKSIE--DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME-- 970
Query: 161 NTNTEMEEVMNDYNML----KAQNDRETQSLDVIFTERQAKEKQIRSVE----EEIEQEK 212
++ + +E+ Y K +++ Q+L + + K K R +E+E+ +
Sbjct: 971 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1030
Query: 213 QATDDIIKNMSFENQVKYLEMKT---------------TNEKLLQELDTLQQQ------- 250
+ D + E+ ++ +E T TN KL ELDTL++
Sbjct: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1090
Query: 251 -------LDSQNMKKESLEAEI-----AHSQVKQEAVLLHEK----LYELESHRD----- 289
L +N K E EI A +Q Q+ L E+ EL RD
Sbjct: 1091 LNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSH 1150
Query: 290 QMIAEDKSI--GSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDL 347
Q + E++S+ +E +++ K IKD ++E AS+++ ++ T + + E+ +L ++
Sbjct: 1151 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV 1210
Query: 348 EEHQGEMNQKYKELKKREEHMDTFIETFEETK-NQELKRKAQIEANIVALLEHCSRNINR 406
+GE N K L + ++T E K ELK K N+ L+ R ++
Sbjct: 1211 TVLRGE-NASAKSL-------HSVVQTLESDKVKLELKVK-----NLELQLKENKRQLS- 1256
Query: 407 IEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQN-LTSDIQRLQLDLQ-KMELL 459
SS N + + +D+ Q+SQ N + D+QR DL+ K+E++
Sbjct: 1257 ----SSSGNTDTQADEDE------RAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1301
Score = 53.1 bits (126), Expect = 7e-07
Identities = 73/344 (21%), Positives = 141/344 (40%), Gaps = 34/344 (9%)
Query: 277 LHEKLYELESHRDQMIAEDK-------SIGSPMEEREKLLKQIKDDN-QEIASMERQLTD 328
L E L E + H +Q++AE S + E E+ L +D + Q + +E ++
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 329 TKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQ 388
+ + E +L LEE + +K ++L+ R E E E R +
Sbjct: 413 LRTMVEAADREKVELLNQLEEEK----RKVEDLQFRVEEESITKGDLEVATVSEKSRIME 468
Query: 389 IEANIVALLEHCSRNINRIEQ--------ISSITNQELKMMQDDLNFKSTEVQKS-QSTA 439
+E ++ ++ + R+E +S QE+ +Q+ L T+ Q+ S
Sbjct: 469 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 528
Query: 440 QNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIK 499
++ + + Q +++ + K+++E SLKSK++ + +D+ AL S E
Sbjct: 529 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKE---NSDVIALWKSKLETAI 585
Query: 500 KLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQ--------ENETHSQLTNLERKWQH 551
HQ+ M + +F K + + E+ LKTQ++ E E + ER
Sbjct: 586 ASHQQAM--EELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA 643
Query: 552 LEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALH 595
E K K +E+ + I+ + K ++ + D L+
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLN 687
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 88.6 bits (218), Expect = 2e-17
Identities = 117/579 (20%), Positives = 244/579 (42%), Gaps = 100/579 (17%)
Query: 98 LGLLRSKISELTTEVNKL----QKGIE-MYNQENSVYLSYEKRAETLAVE----IKELQG 148
LG ++ +EL T++ K+ Q IE + NQ++S ++ K E L + IKE +
Sbjct: 638 LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN 697
Query: 149 QLADYNMLVDKLNTN--TEMEEVMN----------DYNMLKAQNDRETQSLDVIFTERQA 196
L +DK EME+ +N + +L+A+ + +T+ +D ++ +A
Sbjct: 698 SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
Query: 197 KEKQI-------------RSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ- 242
E+++ +S +++ Q+ +A + IK++ E + + + +L
Sbjct: 758 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 817
Query: 243 --ELDTLQQQLDSQNMKKESLEAEIA-----HSQVKQEAVLLHEKLYELESHRDQMIAED 295
+L LQ+ L + KE+LE E+ ++ +EAV + + E + Q +
Sbjct: 818 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
Query: 296 KSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMN 355
+ S +E+ + L ++ +E E QL KEK+ I EI ++ D +MN
Sbjct: 878 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 937
Query: 356 QKYK-----------ELKKREEHMDTFIETFE-----------------ETKNQELKRK- 386
+ + +L K E+ ++ E E + +EL+RK
Sbjct: 938 DELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKL 997
Query: 387 AQIEANIVALLEHCSRNINRIEQISSITNQE----LKMMQDDLNFKSTEVQKSQSTAQNL 442
+ +E + C R E+ +S T + L+ +Q L +++ ++ L
Sbjct: 998 SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1057
Query: 443 TSDIQRLQLDLQK----------MELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKS 492
+++ L+ K M+++E E+ +L S T+ ++ N+L LK
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
Query: 493 SGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHL 552
+ + +++L++ + +L+ ME+ E E LK + QL+ L+
Sbjct: 1118 NNLKNVEELNKSKELLTVENQK----MEEFRKEIETLKQAAAQKS--QQLSALQ------ 1165
Query: 553 EQNNFAMKEFIATKSQESDYQPIKKN---VTKQIAEYNK 588
E+N +E ++ + + +Q +++ + Q+ E K
Sbjct: 1166 EENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1204
Score = 60.1 bits (144), Expect = 6e-09
Identities = 82/398 (20%), Positives = 171/398 (42%), Gaps = 40/398 (10%)
Query: 225 ENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHS-----QVKQEAVLLHE 279
E +Y + L + L QQ ++ +++ AE+A + +++QE L +
Sbjct: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397
Query: 280 ----KLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASM-----ERQLTDTK 330
+ ELE+ DQ+ + + E+ +LL Q++++ +++ + E +T
Sbjct: 398 GHDQHVLELEAKMDQLRT---MVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
Query: 331 EKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETF-EETKNQELKRKAQI 389
+ +E R +++ Q + +K K K + E DT + T E+++ EL++ +
Sbjct: 455 LETQTKLEHARIKELE----QSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLAL 510
Query: 390 EANIVALLEH---CSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKS-QSTAQNLTSD 445
VA L ++ ++ S+ QE+ +Q+ L T+ Q+ S ++ +
Sbjct: 511 RVQEVAELRRRLESNKPAGDVDMSLSLL-QEISSLQEKLEVTRTDHQREITSLKEHFGAR 569
Query: 446 IQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQER 505
+ Q +++ + K+++E SLKSK++ + +D+ AL S E HQ+
Sbjct: 570 EETHQKEIKALYTATEKLSKENESLKSKLEHANKE---NSDVIALWKSKLETAIASHQQA 626
Query: 506 MILSTHRNAFKKIMEKQNIEYEALKTQLQ--------ENETHSQLTNLERKWQHLEQNNF 557
M + +F K + + E+ LKTQ++ E E + ER E
Sbjct: 627 M--EELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 684
Query: 558 AMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALH 595
K K +E+ + I+ + K ++ + D L+
Sbjct: 685 RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLN 722
Score = 55.5 bits (132), Expect = 1e-07
Identities = 97/415 (23%), Positives = 178/415 (42%), Gaps = 84/415 (20%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L+ K+++ + LQK IE + S ++ A+ E KEL+ +L+D ++
Sbjct: 950 LQLKLTKANENASFLQKSIE--DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME-- 1005
Query: 161 NTNTEMEEVMNDYNML----KAQNDRETQSLDVIFTERQAKEKQIRSVE----EEIEQEK 212
++ + +E+ Y K +++ Q+L + + K K R +E+E+ +
Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
Query: 213 QATDDIIKNMSFENQVKYLEMKT---------------TNEKLLQELDTLQQQ------- 250
+ D + E+ ++ +E T TN KL ELDTL++
Sbjct: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1125
Query: 251 -------LDSQNMKKESLEAEI-----AHSQVKQEAVLLHEK----LYELESHRD----- 289
L +N K E EI A +Q Q+ L E+ EL RD
Sbjct: 1126 LNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSH 1185
Query: 290 QMIAEDKSI--GSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDL 347
Q + E++S+ +E +++ K IKD ++E AS+++ ++ T + + E+ +L ++
Sbjct: 1186 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV 1245
Query: 348 EEHQGEMNQKYKELKKREEHMDTFIETFEETK-NQELKRKAQIEANIVALLEHCSRNINR 406
+GE N K L + ++T E K ELK K N+ L+ R ++
Sbjct: 1246 TVLRGE-NASAKSL-------HSVVQTLESDKVKLELKVK-----NLELQLKENKRQLS- 1291
Query: 407 IEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQN-LTSDIQRLQLDLQ-KMELL 459
SS N + + +D+ Q+SQ N + D+QR DL+ K+E++
Sbjct: 1292 ----SSSGNTDTQADEDE------RAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1336
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 86.7 bits (213), Expect = 6e-17
Identities = 104/517 (20%), Positives = 226/517 (43%), Gaps = 60/517 (11%)
Query: 61 LSSQIKVAHRPV---TQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQK 117
L Q ++ H + + + + +K G +GP L + G + +I E+ + + ++
Sbjct: 1152 LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEE---GKSQEQILEILRFIRREKE 1208
Query: 118 GIEMYNQENSVY-LSYEKRAETLAVEIKELQGQL-ADYNMLVDKLNTNTEMEEVMNDYNM 175
E + V L Y +R E L E++ELQ L A+ + T + EE+M
Sbjct: 1209 IAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELM----- 1263
Query: 176 LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKT 235
++T++++V+ K +R +E +EQ+ Q ++ + + L ++
Sbjct: 1264 ------KKTETMNVVMETN----KMLREEKERLEQDLQQMQAKVRKLELD----ILPLQE 1309
Query: 236 TNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAED 295
N +L ++ LQ + K+ LE ++ + + + ++ +K + E +R + ++
Sbjct: 1310 ANAELSEKSGMLQAE-------KKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKE 1362
Query: 296 ---KSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQG 352
K I EE +L +I N + + + + KE +N+ E + DL+
Sbjct: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
Query: 353 EMNQKYKELKKREEHMDTFIETFEETKNQE---LKRKAQIEAN------IVALLEHCSRN 403
++ +K K + + ++ + +EE K Q+ ++ AQ + V ++
Sbjct: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
Query: 404 INRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQ----KMELL 459
+N+ E S +++ +Q L+ K TE + Q L S++ RL+ DLQ + E L
Sbjct: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL 1542
Query: 460 ESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIM 519
++TE++ + I + + A + ++++ K ++E L A +
Sbjct: 1543 RQQITEKEEKTRKAIVAAKSKI-------AHLAGVKDQLTKENEE---LKQRNGALDQQK 1592
Query: 520 EKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNN 556
++ ++ ALK+Q + + + E + +HLEQ +
Sbjct: 1593 DELDVRITALKSQYEGRISRLERELREHQERHLEQRD 1629
Score = 69.7 bits (169), Expect = 7e-12
Identities = 76/439 (17%), Positives = 185/439 (42%), Gaps = 37/439 (8%)
Query: 111 EVNKLQKGIEMYNQEN---SVYLSY-EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEM 166
++ KLQ+ + +N S L + KR E L ++ + ++ + KL T+
Sbjct: 696 QLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQK 755
Query: 167 EEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEE--------EIEQEKQATDDI 218
+E + + + E ++ + E KEK++ + E + E++ + +
Sbjct: 756 QEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLL 815
Query: 219 IKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLH 278
+ N+ + T ++L +++ L+ ++ K E+ E E H+ + V L
Sbjct: 816 LTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLEN-EVEQRHTLTRNLDVQLL 874
Query: 279 EKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLT-----DTKEKI 333
+ +L++ + + + + + +E L + + + ++AS Q T KE +
Sbjct: 875 DTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDV 934
Query: 334 NQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANI 393
+ + ++RQ EE ++ ++ K E + + EE+ N+E + ++ NI
Sbjct: 935 DDLVSQLRQT----EEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNI 990
Query: 394 VALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDL 453
L+ + ++E+ +E + +QDD K ++ + L + +Q ++
Sbjct: 991 EVRLKESAEFQTQLEKKLMEVEKEKQELQDD---KRRAIESMEQQLSELKKTLSSVQNEV 1047
Query: 454 QK-MELLESKMTEEQHSLKSKIKQMTTDLEIYN-----------DLPALKSSGEEKIKKL 501
Q+ ++ + ++ EQ + + +Q +E N D+ AL+++ E+ K
Sbjct: 1048 QEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMA 1107
Query: 502 HQERMILSTHRNAFKKIME 520
+ + T + A +++E
Sbjct: 1108 SVRQHLEETTQKAESQLLE 1126
Score = 66.2 bits (160), Expect = 8e-11
Identities = 98/503 (19%), Positives = 207/503 (41%), Gaps = 69/503 (13%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKL---QKGIEMYNQENSVYLSYEKRAETLAVEIK 144
Q ++++++ LR ++ +L ++ L K +E+ N S R + +
Sbjct: 65 QERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTK------E 118
Query: 145 ELQGQLADYNMLVDKLNTNTEM--EEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIR 202
EL+ + D ++L+ E E+V LK N + + L + E QA + ++
Sbjct: 119 ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGE-LQLKLDELQASDVSVK 177
Query: 203 SVEEEIEQEKQ---------------ATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTL 247
E+ +EQEK+ TD+++ + E + LE+K E +E+ L
Sbjct: 178 YREKRLEQEKELLHSQNTWLNTELKTKTDELLA-LGREKGNEILELKCNLENKKEEVSRL 236
Query: 248 QQQLDSQNMKKESLEAEIAH-----SQVKQEAVLLHEKLY-ELESH----------RDQM 291
++Q++ E L+ + + K++ + EK + EL +H D
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
Query: 292 IAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKI-NQFIEEIRQLDMDLEEH 350
A+ + +EE KLLK+ + N+ I ++ +K+++ + +E+I +L+ +LE
Sbjct: 297 EAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENA 356
Query: 351 QGEMN-QKYKELKKREEHMDTFIETFEET--------KNQELKRKAQIEANIVALLEHCS 401
++ K K EE + T K EL A +E LLE
Sbjct: 357 NDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL-YNAYVETQDQLLLEKLE 415
Query: 402 RNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLT-------SDIQRLQLDLQ 454
RI + +E++ L + E +++Q +L+ +IQRLQ D
Sbjct: 416 N--KRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTD 473
Query: 455 KMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNA 514
K S + + ++ ++K ++ + + L E + + ++ + S ++
Sbjct: 474 KANKQSSVLERDNRRMEIQVKDLSQQIRV-----LLMELEEARGNHVIRDEEVSSADISS 528
Query: 515 FKKIMEKQNIEYEALKTQLQENE 537
+++ + + Y ++ Q+N+
Sbjct: 529 SSEVISQHLVSYRNIEELQQQNQ 551
Score = 62.0 bits (149), Expect = 2e-09
Identities = 88/406 (21%), Positives = 185/406 (45%), Gaps = 78/406 (19%)
Query: 193 ERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELD------- 245
E +A KQ++ + E ++EK + I + Q + ++++ N K+ +LD
Sbjct: 667 EAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYE 726
Query: 246 TLQQQLDSQNMKKESL---EAEIAHSQVKQEAVL---------LHEKLYELESHRDQMIA 293
LQ ++ + SL ++ + KQE ++ +EKL E + +
Sbjct: 727 MLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKK 786
Query: 294 EDKSIGSP----MEEREKLLKQIKDDNQEIAS-------MERQLTDTKEKINQFIEEIRQ 342
E + + ++RE LL + + N + + +ER T+TK++++ IE++
Sbjct: 787 EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKL-- 844
Query: 343 LDMDLEEHQGEMNQKYKELKKREEHMDTFIETFE----ETKNQELKRKAQIEANIVALLE 398
EH E++ K+L+ E T + +TK Q L + + N LL+
Sbjct: 845 ------EH--EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ-LDTETNLHLNTKELLK 895
Query: 399 HCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMEL 458
+ + I ++Q ++N E+++ Q SQ T + S+ + + DL +
Sbjct: 896 NAQKEIATLKQ--HLSNMEVQVAS----------QSSQRTGKGQPSNKEDVD-DL----V 938
Query: 459 LESKMTEEQ-HSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRN---- 513
+ + TEEQ + LK ++K T+++E Y A+ +S EE + K ++++ +N
Sbjct: 939 SQLRQTEEQVNDLKERLKTSTSNVEQYQ---AMVTSLEESLNK--EKQVTEEVRKNIEVR 993
Query: 514 -----AFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQ 554
F+ +EK+ +E E K +LQ+++ + + ++E++ L++
Sbjct: 994 LKESAEFQTQLEKKLMEVEKEKQELQDDKRRA-IESMEQQLSELKK 1038
Score = 61.2 bits (147), Expect = 3e-09
Identities = 84/395 (21%), Positives = 178/395 (45%), Gaps = 49/395 (12%)
Query: 193 ERQAKEKQIRSVEEEIEQ---EKQATDDIIKN----MSFENQVKYLEMKTTNEKLLQELD 245
ER K +SV+ ++E+ ++Q+ D +K E++ +Y E++ + L
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE-------KRLS 62
Query: 246 TLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEER 305
Q++L ++ + +SL E+ ++ + L EK ELE +D+ IA EE
Sbjct: 63 HSQERLVNETRECQSLRLEL--EKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIR----QLDMDLEEHQ-GEMNQKYKE 360
E + + N+ ++ LT+ +++N+ ++E +L + L+E Q +++ KY+E
Sbjct: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
Query: 361 LKKREE-----HMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITN 415
+ +E +T++ T +TK EL + + N + L+ C+ N+ E++S +
Sbjct: 181 KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELK-CNLE-NKKEEVSRLEE 238
Query: 416 QELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHS-LKSKI 474
Q + +++ ++L ++ L L++ + ++ M E+ H+ L + I
Sbjct: 239 Q---------------MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHI 283
Query: 475 KQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQ 534
K +D A + +++LH+ L K ++ +E E K Q+
Sbjct: 284 KLSNLYKSAADDSEAKSNELTRAVEELHK----LLKEAGEANKAIQDHLLEVEQSKDQM- 338
Query: 535 ENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQE 569
E E ++ LE++ ++ A K A S+E
Sbjct: 339 EKEMLEKIGRLEKELENANDLLSATKRKGAILSEE 373
Score = 51.2 bits (121), Expect = 3e-06
Identities = 98/519 (18%), Positives = 202/519 (38%), Gaps = 38/519 (7%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEV-NKLQKGIEMYNQENSVYLSY 132
++ + G+KT + Q+ + D L + + + + + N+L I++ N S
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
Query: 133 EKRAETLAVEIKELQGQL---ADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDV 189
E ++ L ++EL L + N + E + + ML+ E + +
Sbjct: 297 EAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENA 356
Query: 190 IFTERQAKEKQIRSVEEEI---EQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDT 246
K K EEE+ A I+K ++ ++T ++ LL++L+
Sbjct: 357 NDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLEN 416
Query: 247 LQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEERE 306
+ + KE V+ +A +L + E E + + + + M+E +
Sbjct: 417 KRINKYLDEIVKE----------VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ 466
Query: 307 KLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREE 366
+L + N++ + +ER + ++ ++IR L M+LEE +G + +E+ +
Sbjct: 467 RLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
Query: 367 HMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQ---ISSITNQELKMMQD 423
+ + + + ++ Q ++ L R EQ S IT +LK+ +
Sbjct: 527 SSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKL--E 584
Query: 424 DLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLES--------KMTEEQHSLKSKIK 475
+ +++KS+ L I R Q D+ ++ L ++ + + SL S K
Sbjct: 585 SALTELEQLRKSRQHQMQLVDSIVR-QRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK 643
Query: 476 QMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEAL-KTQLQ 534
+ +T + P E I+ + + N K+ E + I+ E L K Q Q
Sbjct: 644 RPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQ 703
Query: 535 ENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQ 573
+ SQ T + Q +FA K + + Y+
Sbjct: 704 VTDLRSQNTKIS------TQLDFASKRYEMLQDNVEGYR 736
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 86.3 bits (212), Expect = 7e-17
Identities = 126/565 (22%), Positives = 250/565 (44%), Gaps = 108/565 (19%)
Query: 104 KISELTTEVNKLQKGIEMYN------QENSVYLSYEKRAETLAVEIKELQGQLADYNMLV 157
+++ + E +L++ +E +E V L EK L ++++ Q LAD
Sbjct: 848 EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKN--DLQLQVQAEQDNLADAEERC 905
Query: 158 DKLNTNT--------EMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIE 209
D+L N EM E + D + A+ + + L+ +E + + ++E
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVE 965
Query: 210 QEKQATDDIIKNMSFE--NQVKYLEMKTTNEKLLQE-----LDTLQQQLDSQNM------ 256
+EK AT++ +KN++ E + + T +K LQE LD LQ + D N
Sbjct: 966 KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025
Query: 257 ----------------KKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQM--------- 291
KK ++ E A +++ + L E + +LE+ + Q+
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDF 1085
Query: 292 --------IAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIE-EIRQ 342
I +++++GS ++++ K L+ ++ +E ER EK+ + E+ +
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1145
Query: 343 LDMDLEEHQG------EMNQK----YKELKK----------------REEHMDTFIETFE 376
+ LEE G EMN+K ++++++ R++H D+ E E
Sbjct: 1146 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE 1205
Query: 377 ETKN-QELKRKAQIEANIVAL-LEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQK 434
+ N Q +K+K + E + L L+ + N+ +I + + + + ++D +N ++ ++
Sbjct: 1206 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEE 1265
Query: 435 SQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIY-NDLPALKSS 493
+Q + +LTS QR +L + EL S+ +E+ +L I Q+T Y L LK
Sbjct: 1266 TQRSVNDLTS--QRAKLQTENGEL--SRQLDEKEAL---ISQLTRGKLTYTQQLEDLKRQ 1318
Query: 494 GEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQE--NETHSQLTNLERKW-- 549
EE++K + L + R+ + E+ E EA K +LQ ++ +S++ K+
Sbjct: 1319 LEEEVKAKNALAHALQSARHDCDLLREQYEEETEA-KAELQRVLSKANSEVAQWRTKYET 1377
Query: 550 ---QHLEQNNFAMKEFIATKSQESD 571
Q E+ A K+ +A + QE++
Sbjct: 1378 DAIQRTEELEEAKKK-LAQRLQEAE 1401
Score = 77.0 bits (188), Expect = 5e-14
Identities = 115/522 (22%), Positives = 222/522 (42%), Gaps = 95/522 (18%)
Query: 100 LLRSKISELTTEVNKLQKGIEMYNQENSVYLS-YE----KRAETLAVEIKELQGQLADYN 154
LLR + E T +LQ+ + N E + + + YE +R E L K+L +L +
Sbjct: 1342 LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1401
Query: 155 MLVDKLNTN------------TEMEEVMNDY---NMLKAQNDRETQSLDVIFTERQAKEK 199
V+ +N E+E++M D N A D++ ++ D I E + K +
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1461
Query: 200 QIRSVEEEIEQEKQATDDIIKNM--SFENQVKYLE-MKTTNEKLLQELDTLQQQLDSQNM 256
+ +S E ++E ++ + + ++E +++LE K N+ L +E+ L +QL S
Sbjct: 1462 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSG- 1520
Query: 257 KKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEERE--------KL 308
+ ++ELE R Q+ AE + S +EE E K+
Sbjct: 1521 ----------------------KTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI 1558
Query: 309 LKQIKDDNQEIASMERQLTDTKEKINQ----FIEEIRQLDMDLEEHQGEMNQKYKELKKR 364
L+ + NQ A +ER+L + E++ Q + + L L+ N+ + KK
Sbjct: 1559 LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKM 1618
Query: 365 EEHMDTF-----------IETFEETKN-QELKRKAQIEA-NIVALLEHCSRNINRIEQIS 411
E ++ E ++ K+ Q L + QI+ + V + NI +E+ +
Sbjct: 1619 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN 1678
Query: 412 SITNQEL--------------KMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKME 457
++ EL K+ + +L S VQ S +L + +++ DL +++
Sbjct: 1679 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ 1738
Query: 458 LLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERM---ILSTHRNA 514
+ +E + + K K+ TD + + LK +E+ H ERM + T ++
Sbjct: 1739 TEVEEAVQECRNAEEKAKKAITDAAMMAE--ELK---KEQDTSAHLERMKKNMEQTIKDL 1793
Query: 515 FKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNN 556
++ E + I + K QLQ+ E +++ LE + + ++ N
Sbjct: 1794 QHRLDEAEQIALKGGKKQLQKLE--ARVRELENELEAEQKRN 1833
Score = 63.2 bits (152), Expect = 7e-10
Identities = 82/388 (21%), Positives = 168/388 (43%), Gaps = 62/388 (15%)
Query: 229 KYLEMKTTNEKLLQELDTLQQQLDS---------------QNMKKESLEAEIAHSQVKQE 273
++++ + EKLL LD Q + M+ E L I Q +
Sbjct: 734 QFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSR 793
Query: 274 AVLLHEKLYELESHRDQMIAEDKSIGSPMEERE----KLLKQIK------DDNQEIASME 323
VL + +L RD ++ +I + M + KL +IK + +E+ASM+
Sbjct: 794 GVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMK 853
Query: 324 RQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQEL 383
+ T KE + + E R+ +LEE + Q+ +L+ + + + EE +Q +
Sbjct: 854 EEFTRLKEALEK--SEARR--KELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Query: 384 KRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLT 443
K K Q+EA + + E R+E ++++N + T ++ L
Sbjct: 910 KNKIQLEAKVKEMNE-------RLED------------EEEMNAELTAKKRK------LE 944
Query: 444 SDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQ 503
+ L+ D+ +EL +K+ +E+H+ ++K+K +T ++ +++ A + ++ +++ HQ
Sbjct: 945 DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Query: 504 ERM----ILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAM 559
+ + N K K + + L+ L++ + +LER + LE +
Sbjct: 1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEK--KVRMDLERAKRKLEGDLKLT 1062
Query: 560 KEFIATKSQESDYQPIKKNVTKQIAEYN 587
+E I E+D Q + + + K+ E N
Sbjct: 1063 QESI--MDLENDKQQLDERLKKKDFELN 1088
Score = 55.1 bits (131), Expect = 2e-07
Identities = 75/347 (21%), Positives = 157/347 (45%), Gaps = 44/347 (12%)
Query: 111 EVNKLQKGIEMYNQENSVYLSYEKR-AETLAVEIKELQGQLADYNM-LVDKLNTNTEMEE 168
E +++K +E E + LS+ R A ++K LQ L D + L D + N +++E
Sbjct: 1610 EALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE 1669
Query: 169 VMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQV 228
+ A +R L QA+ +++R+V E+ E+ ++ + + S +V
Sbjct: 1670 NI-------AIVERRNNLL-------QAELEELRAVVEQTERSRKLAEQELIETS--ERV 1713
Query: 229 KYLEMKTT---NEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELE 285
+ L + T N+K + D Q Q + + +E AE + +A ++ E EL+
Sbjct: 1714 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAE---ELK 1770
Query: 286 SHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDM 345
+D A + + ME+ K L+ D+ ++IA L K+++ + +R+L+
Sbjct: 1771 KEQDTS-AHLERMKKNMEQTIKDLQHRLDEAEQIA-----LKGGKKQLQKLEARVRELEN 1824
Query: 346 DLEEHQGEMNQKYKELKKREEHM-DTFIETFEETKN----QELKRKAQIEANIV-----A 395
+LE Q + K ++K E + + +T E+ KN Q+L K Q++
Sbjct: 1825 ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEE 1884
Query: 396 LLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNL 442
E + N+++ ++ EL ++ + ++V K ++ ++++
Sbjct: 1885 AEEQANTNLSKFRKV----QHELDEAEERADIAESQVNKLRAKSRDI 1927
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 85.1 bits (209), Expect = 2e-16
Identities = 124/551 (22%), Positives = 236/551 (42%), Gaps = 91/551 (16%)
Query: 114 KLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNT-EMEEVMND 172
K + +E + N ++ K A+ + L+ +L+ +L T E++E +N+
Sbjct: 832 KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELS---YKTQELQEKTREVQERLNE 888
Query: 173 YNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLE 232
LK Q + +L + E+ ++++ EE++ Q DD+ K + Q++ +
Sbjct: 889 MEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL-KQLQESLQIERDQ 947
Query: 233 MKT-----------TNEKLLQELDTLQQQLDSQNMKKESLEAEIAHS--------QVK-- 271
+K+ T E+L L++L+Q ++ N K + E++ + + K
Sbjct: 948 LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007
Query: 272 -QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQ-------EIASME 323
Q+ ++ +K +LE+ Q + D +E++ K+ I++ N+ IA E
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 324 RQLTDTKEKINQFIE---EIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEET-- 378
+ TD KE I IE E+R L +L++ Q + Q+ K+E + + E
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 379 ----KNQELKRKAQIEANIVALLEHCSRNINRIEQI-SSITNQEL--------------K 419
K+Q+L+ K Q N+ + + IN IE + + + N+EL K
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 420 MMQDDLNFKS--------TEVQKSQSTAQ-NLTSDIQRLQL----DLQKMELLESKMTEE 466
+ ++ KS E+QKS T + +L I+ ++ +++++ + E
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEH 1247
Query: 467 QHS---LKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQN 523
Q + L+ + + T + DL + +E+I LH+E+ +L K++ E Q
Sbjct: 1248 QETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN----VKEVSETQE 1303
Query: 524 IEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQI 583
E L E T T L R +E + E K QES Q K++TK+
Sbjct: 1304 TMNEL--ELLTEQSTTKDSTTLAR----IEMERLRLNE----KFQES--QEEIKSLTKE- 1350
Query: 584 AEYNKTIVDAL 594
+ KTI +AL
Sbjct: 1351 RDNLKTIKEAL 1361
Score = 84.3 bits (207), Expect = 3e-16
Identities = 111/498 (22%), Positives = 214/498 (42%), Gaps = 61/498 (12%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQ--ENSVYLSYEKRAETLAVEIKELQGQLADYNMLVD 158
LR +SE TE++ +QK +E N +N + YEK + +I E+Q +
Sbjct: 1496 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ----------E 1545
Query: 159 KLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEE---EIEQEKQAT 215
K+N + +E R+AK+ ++S+E E+ Q +
Sbjct: 1546 KVNELKQFKE------------------------HRKAKDSALQSIESKMLELTNRLQES 1581
Query: 216 DDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMK-KESLEAEIAHSQVKQEA 274
+ I+ M E + EMK E L E D L++ K KES E E + +K A
Sbjct: 1582 QEEIQIMIKEKE----EMKRVQEALQIERDQLKENTKEIVAKMKESQEKE--YQFLKMTA 1635
Query: 275 VL-LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKI 333
V EK+ E+E ++Q + ++ + E +L + + ++ +E+ S+ ++ D +
Sbjct: 1636 VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVE 1695
Query: 334 NQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANI 393
E QL +L E +K +ELK H+ ET ++ + ++ +I +N+
Sbjct: 1696 ETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEI-SNM 1754
Query: 394 VALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDL 453
LEH S + + + + +EL++ L + + K + T + +Q DL
Sbjct: 1755 QKDLEH-SNDALKAQDLK--IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL 1811
Query: 454 QKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRN 513
+ +K+ E+ LK+ Q+ T + N+ S E+ K++ + + LS
Sbjct: 1812 ENS---NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEI 1868
Query: 514 AFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFI-ATKSQESDY 572
+ +K + E +K+ ++E + NL R + L+ +KE + TK+++ +
Sbjct: 1869 ENLNLAQKLHENLEEMKSVMKERD------NLRRVEETLKLERDQLKESLQETKARDLEI 1922
Query: 573 QPIKKNVTKQIAEYNKTI 590
Q K E+ +T+
Sbjct: 1923 QQELKTARMLSKEHKETV 1940
Score = 73.9 bits (180), Expect = 4e-13
Identities = 99/515 (19%), Positives = 226/515 (43%), Gaps = 58/515 (11%)
Query: 130 LSYEKRAETLAVEIKELQGQLADYNMLVD-----KLNTNTEMEEVMNDYNMLKAQNDRET 184
L +++ + LA K+++ + Y ++ +++ E++ N+ L + D +
Sbjct: 649 LELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV 708
Query: 185 QSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQEL 244
+ E + K I +++E+ +E + + + + + +++K L + E+L +E+
Sbjct: 709 PKDLLCNLELEGK---ITDLQKELNKEVEENEALREEVILLSELKSLPSEV--ERLRKEI 763
Query: 245 DTLQQQLDSQNMKKESLEAEIAHSQVKQEAVL-----LHEKLYELESH---RDQMIAEDK 296
++L +K+ L +E+ H + + + +L + L +S+ DQ K
Sbjct: 764 QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFK 823
Query: 297 SIGSPMEEREKL-LKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMN 355
++ E++ K+ L++ + NQEI ++ ++ + E+ +L+E E+
Sbjct: 824 TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQ 883
Query: 356 QKYKE---LKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISS 412
++ E LK++ E+ D+ ++T E K + K Q V L ++ ++++
Sbjct: 884 ERLNEMEQLKEQLENRDSTLQTVEREKTL-ITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942
Query: 413 ITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEE------ 466
I +LK D V + T + L + ++ L+ + + L+SK++EE
Sbjct: 943 IERDQLKSDIHD------TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLH 996
Query: 467 ----QHSLKSKIKQMTTDLEIYNDLPALK----SSGEEKIKKLHQERMILS--THRNAFK 516
K + +Q ++ DL A ++ + + + Q+R I S +N +
Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056
Query: 517 KIMEKQNIEYEALKTQLQEN-----ETHSQLTNLE---RKWQHL--EQNNFAMK---EFI 563
+++E E E LKT L+EN E +L L +K Q + ++ N A+K E
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Query: 564 ATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTS 598
T + ++ + K ++Q+ E + +++ S
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS 1151
Score = 71.2 bits (173), Expect = 2e-12
Identities = 106/487 (21%), Positives = 209/487 (42%), Gaps = 79/487 (16%)
Query: 145 ELQGQLADY-NMLVDKLNTNTEMEEV---------MNDYNML--KAQNDRETQSLDVIFT 192
EL ADY N+++D TE EE+ ++++ L K + D+E Q + I
Sbjct: 499 ELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISN 558
Query: 193 ERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLD 252
+ K +++E E + ++++ E+Q+K L+ ++KL L L+
Sbjct: 559 LKNLV-KHAEVYNQDLENELSSKVELLREK--EDQIKKLQEYIDSQKLENIKMDLSYSLE 615
Query: 253 S----QNMKKESLEAEIAHSQVKQEAVLLH-------EKLYELESHRDQMIAEDKSIGSP 301
S + MK+ +AE K+E+ L EK+ EL + QM + + S
Sbjct: 616 SIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQ 675
Query: 302 MEEREK----LLKQIKDDNQEIA------------------SMERQLTDTKEKINQFIEE 339
+E ++K L K+++ EI +E ++TD ++++N+ +EE
Sbjct: 676 LEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEE 735
Query: 340 ---IRQ---LDMDLEEHQGEMNQKYKELKKREEHMDTFI----ETFEETKNQELKRKAQI 389
+R+ L +L+ E+ + KE++ + E + + F E ++E + + +
Sbjct: 736 NEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLL 795
Query: 390 E---------ANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQ 440
E A + + + + + Q+ KM+ ++ + E+ AQ
Sbjct: 796 EEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQ 855
Query: 441 NLTSDIQRLQLDLQ-KMELLESKMTEEQHSLKSKIKQMTTDLE----IYNDLPALKSSGE 495
S + L+ +L K + L+ K E Q L ++++Q+ LE + K+
Sbjct: 856 KFDSSLGALKTELSYKTQELQEKTREVQERL-NEMEQLKEQLENRDSTLQTVEREKTLIT 914
Query: 496 EKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQEN-----ETHSQLTN-LERKW 549
EK+++ +E L+ ++ K++ E IE + LK+ + + +T QL N LE
Sbjct: 915 EKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK 974
Query: 550 QHLEQNN 556
QH E N
Sbjct: 975 QHQETIN 981
Score = 69.3 bits (168), Expect = 9e-12
Identities = 114/511 (22%), Positives = 226/511 (44%), Gaps = 79/511 (15%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
LR +SE T ++ Q EK L EI L + L+ +
Sbjct: 1254 LRRSVSEKTAQIINTQ--------------DLEKSHTKLQEEIPVLHEE----QELLPNV 1295
Query: 161 NTNTEMEEVMNDYNMLKAQND-RETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDII 219
+E +E MN+ +L Q+ +++ +L I ER ++ + +EEI+ + D++
Sbjct: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL- 1354
Query: 220 KNMSFENQVKYLEMKTTNEKLLQELDTLQ-QQLDSQNMKKESLEAEIAHSQVKQ----EA 274
K + +VK+ ++K + L ++ Q +Q S NMK++ E S+++Q ++
Sbjct: 1355 KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDS 1414
Query: 275 VLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN 334
LL ++ +M+ K + +E + + K+ KDD Q + + L +++
Sbjct: 1415 ALLRIEI--------EMLGLSKRLQESHDEMKSVAKE-KDDLQRLQEV---LQSESDQLK 1462
Query: 335 QFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEA--- 391
+ I+EI ++ EE E+ + LK++EE ++ E + + + Q+EA
Sbjct: 1463 ENIKEIVAKHLETEE---ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIND 1519
Query: 392 ----NIVALLEHCSR-NINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDI 446
I + E + NI +I ++ N ELK ++ K + +Q +S LT+ +
Sbjct: 1520 KLQNKIQEIYEKEEQFNIKQISEVQEKVN-ELKQFKEHRKAKDSALQSIESKMLELTNRL 1578
Query: 447 QRLQLDLQKMELLESKMTEEQHSL---KSKIKQMTTDLEIYNDLPALKSSGEEKIKKLH- 502
Q Q ++Q M + +M Q +L + ++K+ T ++ + +K S E++ + L
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEI-----VAKMKESQEKEYQFLKM 1633
Query: 503 ------QERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNN 556
QE+M H K+ E Q + E ++T EN +Q+ + ++LE+
Sbjct: 1634 TAVNETQEKMCEIEH---LKEQFETQKLNLENIET---ENIRLTQILH-----ENLEEMR 1682
Query: 557 FAMKEFIATKSQES----DYQPIKKNVTKQI 583
KE +S E + +K+N+ + I
Sbjct: 1683 SVTKERDDLRSVEETLKVERDQLKENLRETI 1713
Score = 63.2 bits (152), Expect = 7e-10
Identities = 110/568 (19%), Positives = 237/568 (41%), Gaps = 89/568 (15%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
++QI D+S L L + L KL + +E + + ETL +E +L+
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLA---QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLK 1909
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
L + T E+ + + + +++D + + K QI ++++
Sbjct: 1910 ESLQE---------TKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKD 1960
Query: 208 IEQEKQATDDIIKNMSFENQVKYLEMK---TTNEKLLQELDTLQQQLDSQNMKKESLEAE 264
+++ K I+ + + +++ L +K + K + E++ L++Q ++QN+ +S+ +
Sbjct: 1961 LDKSKDELQKKIQELQ-KKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMD 2019
Query: 265 IAHSQVKQEAVLLHEKLYELE---SHRDQMIAEDKSIGSPMEEREKLLKQIKD------D 315
K LHE L E+ RD++ +S+ ER++ + +++
Sbjct: 2020 NFQLTKK-----LHESLEEIRIVAKERDELRRIKESLKM---ERDQFIATLREMIARDRQ 2071
Query: 316 NQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETF 375
N ++ +R L+D ++ + + + E +L + EM+ Y+ L + ++ IE
Sbjct: 2072 NHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQ 2131
Query: 376 EE-----------------------TKNQE--------LKRKAQIEANIVALLEHCSRNI 404
+E T NQ +K+ + + + + E +I
Sbjct: 2132 KELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESI 2191
Query: 405 NRIEQ--ISSITNQ-----ELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKME 457
N+ E I + Q +++ +Q D + S E+ + QN+ I+ + D + E
Sbjct: 2192 NKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSREL-RDLKLNQNMDLHIEEILKDFSESE 2250
Query: 458 LLESKMTEEQHSLKSKIKQMTTDLEIY----NDLPALKSSGEEKIKKLHQERMILSTHRN 513
K TE Q L ++ K+MT LE + D+ LK+ +++ ++ Q + + N
Sbjct: 2251 FPSIK-TEFQQVLSNR-KEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ---VNNFFNN 2305
Query: 514 AFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQ 573
IM ++ E+E + + E L +L+ K + L +N +K +A+ +Q +
Sbjct: 2306 RIIAIM-NESTEFEERSATISK-EWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTT 2363
Query: 574 PIKKN------VTKQIAEYNKTIVDALH 595
KN T+ E + + ++LH
Sbjct: 2364 QDNKNPHVTSRATQLTTEKIRELENSLH 2391
Score = 57.4 bits (137), Expect = 4e-08
Identities = 92/494 (18%), Positives = 224/494 (45%), Gaps = 74/494 (14%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVE--IKELQGQLADYNMLV- 157
LRS L E ++L++ N ++ EK+ E V +KE Q + +V
Sbjct: 1691 LRSVEETLKVERDQLKE-----NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVS 1745
Query: 158 DKLNTNTEMEEVMNDYN-MLKAQNDRETQSLDVI---FTERQAKEKQIRSVEEEIEQEKQ 213
+K N + M++ + N LKAQ+ + + L + E+Q ++R + E +
Sbjct: 1746 EKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS 1805
Query: 214 ATDDIIKNMSFENQVKYLEMKTTNEKLL---QELDTLQQQL-DSQNMKKESLEAEIAHSQ 269
++N + + Q K E+K +L+ ++++ Q+++ + + +KK+ + + S+
Sbjct: 1806 NMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK 1865
Query: 270 VKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDT 329
++ E + L +KL+E + E KS+ M+ER+ L + + E ++ L +T
Sbjct: 1866 LEIENLNLAQKLHE-------NLEEMKSV---MKERDNLRRVEETLKLERDQLKESLQET 1915
Query: 330 KEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQI 389
K + + +E++ M +EH+ +++ +++ ++ + + +++K++ K+ ++
Sbjct: 1916 KARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQEL 1975
Query: 390 EANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRL 449
+ + LL R+++ +++++++ M E K Q AQNL+
Sbjct: 1976 QKKELQLL--------RVKEDVNMSHKKINEM---------EQLKKQFEAQNLS------ 2012
Query: 450 QLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQER-MIL 508
+Q + + ++T++ H +I+ + + + +L +K S L ER +
Sbjct: 2013 ---MQSVRMDNFQLTKKLHESLEEIRIVAKERD---ELRRIKES-------LKMERDQFI 2059
Query: 509 STHRNAFKKIMEKQNIEYEALKTQLQENETH---------SQLTNLERKWQHLEQNNFAM 559
+T R + ++QN + + K L + + H S++ L +++ ++ + +
Sbjct: 2060 ATLREMIAR--DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECL 2117
Query: 560 KEFIATKSQESDYQ 573
+E ++Q
Sbjct: 2118 NRLSLDLEKEIEFQ 2131
Score = 38.1 bits (87), Expect = 0.023
Identities = 92/441 (20%), Positives = 181/441 (41%), Gaps = 80/441 (18%)
Query: 114 KLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK-LNTNTEMEEVMND 172
KL + ++++ +E S E ++ E +++ + +++ LNT ++E++ N
Sbjct: 2230 KLNQNMDLHIEEILKDFS-ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNG 2288
Query: 173 YNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLE 232
++ +NDR Q ++ F R I ++ E + ++ + I K +E +K L+
Sbjct: 2289 ---IQKENDRICQ-VNNFFNNR------IIAIMNESTEFEERSATISKE--WEQDLKSLK 2336
Query: 233 MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMI 292
K NEKL + TL+ L S + + + L EK+ ELE+ +
Sbjct: 2337 EK--NEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENS----L 2390
Query: 293 AEDKSIGSPMEEREKLLKQIKD---DNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEE 349
E K S M + K++K K+ N IA ++ ++ ++ N+ +E+ ++ L++
Sbjct: 2391 HEAKE--SAMHKESKIIKMQKELEVTNDIIAKLQAKVHES----NKCLEKTKETIQVLQD 2444
Query: 350 HQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQ 409
+ YKE + ++LK K +V + +N E+
Sbjct: 2445 KVALGAKPYKE------------------EIEDLKMK------LVKIDLEKMKNAKEFEK 2480
Query: 410 ISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHS 469
S T ++ ++ + +++SQ TS I S+ T+ Q S
Sbjct: 2481 EISATKATVEYQKEVIRLLRENLRRSQQAQD--TSVI--------------SEHTDPQPS 2524
Query: 470 LK-------SKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQ 522
K S I Q T L + ++ L E++I KL Q+ L +N +
Sbjct: 2525 NKPLTCGGGSGIVQNTKALILKSEHIRL----EKEISKLKQQNEQLIKQKNELLSNNQHL 2580
Query: 523 NIEYEALKTQLQENETHSQLT 543
+ E + K + + E H Q+T
Sbjct: 2581 SNEVKTWKERTLKREAHKQVT 2601
>gi|7705415 hook homolog 1 [Homo sapiens]
Length = 728
Score = 84.3 bits (207), Expect = 3e-16
Identities = 106/482 (21%), Positives = 211/482 (43%), Gaps = 59/482 (12%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK- 159
LR + EL +V LQ +++NS+ E E L +L G D N +V K
Sbjct: 197 LRQRCEELDMQVTTLQ------DEKNSLVSENEMMNEKL----DQLDGSFDDPNTVVAKK 246
Query: 160 -LNTNTEMEEVMNDYNMLKAQNDR---ETQSLDVIFTERQAKEKQIRSVEEEIEQEK--- 212
+ ++E++ + L+A D + L+ E Q + ++ S+ EE K
Sbjct: 247 YFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEI 306
Query: 213 ---QATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQ-----QLDSQNMKKESLEAE 264
+AT D + ++ +++ N+ L +++ TLQ+ ++ ++++E +A
Sbjct: 307 DVLRATSDKANKLESTVEIYRQKLQDLND-LRKQVKTLQETNMMYMHNTVSLEEELKKAN 365
Query: 265 IAHSQV---KQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIAS 321
A +Q+ K++ LH KL D + E K + E+ E LLK+
Sbjct: 366 AARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLE---EKHEALLKE---------- 412
Query: 322 MERQLTDTKEKINQFIEEIR--QLDMD-LEEHQGEMNQKYKELKKR---EEHMDTFIETF 375
+ +L + ++ + + EE+R Q+ D L + + Y+ L E+ + FI
Sbjct: 413 -KERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQ 471
Query: 376 EETKNQELKRKAQIEANIVAL---LEHCSRNINRIEQISSITNQELKMMQDDLNF--KST 430
E K L+++ I L LE R +N +E ++ + ++ +Q + KS
Sbjct: 472 HENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSL 531
Query: 431 EVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPAL 490
+ Q S+S ++ + Q+L+ ++K+ + ++ ++Q ++ + +++ N+L A
Sbjct: 532 QEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAA 591
Query: 491 KSSGEEKIKKLHQE-RMILSTHRNAFKKIMEKQN---IEYEALKTQLQENETHSQLTNLE 546
+E +K + + +M L RN K + K N E L+ QL E E ++ E
Sbjct: 592 LQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESE 651
Query: 547 RK 548
K
Sbjct: 652 CK 653
Score = 52.0 bits (123), Expect = 2e-06
Identities = 57/314 (18%), Positives = 132/314 (42%), Gaps = 6/314 (1%)
Query: 260 SLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAE-DKSIGSPMEEREKLLKQIKDDNQE 318
+LE + H + L+ +++ L S + + E ++ + +EE ++ L + ++ Q
Sbjct: 143 TLEESVQHVVMTAIQELMSKEI--LSSPPNDAVGELEQQLKRALEELQEALAEKEELRQR 200
Query: 319 IASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEET 378
++ Q+T +++ N + E ++ L++ G + + K+ H +E +E
Sbjct: 201 CEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEE 260
Query: 379 KNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQ--ELKMMQDDLNFKSTEVQKSQ 436
+ K + L + +R ++++S+ + LK D L S + K +
Sbjct: 261 NFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLE 320
Query: 437 STAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEE 496
ST + +Q L ++++ L+ H+ S +++ L K ++
Sbjct: 321 STVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQD 380
Query: 497 KIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNN 556
KL E T K++ EK + + +++ +T + TN E + ++Q++
Sbjct: 381 LHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKE-TNEELRCSQVQQDH 439
Query: 557 FAMKEFIATKSQES 570
+ ATKS E+
Sbjct: 440 LNQTDASATKSYEN 453
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 84.0 bits (206), Expect = 4e-16
Identities = 139/646 (21%), Positives = 275/646 (42%), Gaps = 85/646 (13%)
Query: 10 ARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARP----GSRGCPIGTGGVLSSQI 65
+RP++ G V + G PP+G + G PP + P G C + L +++
Sbjct: 1273 SRPLTPGTV-VYGPPPAGAPMVYG------PPPPNFSIPFIPMGVLHCNVPEHHNLENEV 1325
Query: 66 K-----VAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
+ H ++ M+ + ++++ + + + L + L EV +L + ++
Sbjct: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLN----TNTEMEEVMNDYNML 176
Q+ + E+L E+ E++ L + +VD++ T + + + + L
Sbjct: 1386 KRQQQKDFI---DGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRL 1441
Query: 177 KAQNDRE-------TQSLDVIFTERQAKEKQIRSVEEEIEQEKQATD-DIIKN----MSF 224
A+ + E T++ FT+ + Q S EE+E+ Q T +++K S
Sbjct: 1442 LAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSL 1501
Query: 225 ENQVKYLEM-KTTNEKLLQELDTLQQQLDSQ----NMKKESLEAEIAHSQVKQEAVLLHE 279
+ K LE K E++L+E++ + DS + KKE L E+ Q Q+ + + E
Sbjct: 1502 QADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEEL---QKLQKDIEMAE 1558
Query: 280 KLYELESHRDQMIAEDKSI-GSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIE 338
+ E H Q++ E + + + E EKL Q+ QE+A ++RQL KE+++
Sbjct: 1559 RN---EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
Query: 339 EIRQLDMDLEE----HQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQI----- 389
+ Q DL+E + E+ +K +++ + ++ E Q +RK Q+
Sbjct: 1616 SMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQ 1675
Query: 390 -----EANIVALLEHCSRN---INRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQN 441
E N+ +L S++ + I + + N EL+ ++ + + +E++K+Q
Sbjct: 1676 EIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLE 1735
Query: 442 LTSDIQRLQ--LDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKI- 498
+++ LQ QK E+ K E+ K +I++MT + S +E +
Sbjct: 1736 EKLELENLQQISQQQKGEIEWQKQLLERD--KREIERMTAESRALQSCVECLSKEKEDLQ 1793
Query: 499 -------KKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQH 551
KKL Q + +L+ K ME+ N+E K +L + +L L R
Sbjct: 1794 EKCDIWEKKLAQTKRVLAAAEENSK--MEQSNLE----KLELNVRKLQQELDQLNRDKLS 1847
Query: 552 LEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHST 597
L + AM++ + K + +++ + N D LH+T
Sbjct: 1848 LHNDISAMQQQLQEKREA--VNSLQEELANVQDHLNLAKQDLLHTT 1891
Score = 78.6 bits (192), Expect = 2e-14
Identities = 104/504 (20%), Positives = 218/504 (43%), Gaps = 51/504 (10%)
Query: 104 KISELTTEV--NKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLN 161
KISE ++ +L +++ N+ L E + E EI Q ++ D + +D L+
Sbjct: 485 KISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLD 544
Query: 162 TNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
+ ++ +KAQ + Q LD++ + Q E ++ + I +E + D+ +
Sbjct: 545 SKDPK------HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQ 598
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQ--NMKKESLEAEIAHSQVKQEAVLLHE 279
++ E Q+ NE L ++L+ + L +K ++ +A+ +++ E L +
Sbjct: 599 LT-EGQI------AANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQ 651
Query: 280 KLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEE 339
+L E+E RDQ+ + + E K L +++ QE + L T+ ++ + E
Sbjct: 652 RLTEVEQERDQL----EIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAE 707
Query: 340 IRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEH 399
L+ L E NQ +EL+K + + + EL+++ Q N + +
Sbjct: 708 ---LEARLNLRDAEANQLKEELEK----VTRLTQLEQSALQAELEKERQALKNALGKAQF 760
Query: 400 CSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELL 459
EQ +S + +LK +QDD N +++ Q+ ++ + R + +++ L
Sbjct: 761 SEEK----EQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDEL 816
Query: 460 ESKM---TEEQ--HSLKSKIKQMTTDL-----EIYNDLPALKSSGEEKIKKLHQERMI-- 507
K+ T E HS + + DL EI + + + +KL +E +
Sbjct: 817 RRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQ 876
Query: 508 --LSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIA- 564
L+T + F++ E+ EA + + + +++ +E + +L++N +M+E
Sbjct: 877 EKLATGQEEFRQACER---ALEA-RMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGL 932
Query: 565 TKSQESDYQPIKKNVTKQIAEYNK 588
T Q + K+ + Q+ E K
Sbjct: 933 TDLQLQEADEEKERILAQLRELEK 956
Score = 77.8 bits (190), Expect = 3e-14
Identities = 96/482 (19%), Positives = 205/482 (42%), Gaps = 55/482 (11%)
Query: 102 RSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLN 161
+S + +L V KLQ+ ++ N++ +L +I +Q QL + V+ L
Sbjct: 1821 QSNLEKLELNVRKLQQELDQLNRDKL----------SLHNDISAMQQQLQEKREAVNSLQ 1870
Query: 162 TNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIE--QEKQATDDII 219
E+ V + N+ K T+ DV+ +E+ +K I E Q+++ T
Sbjct: 1871 E--ELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETK--- 1925
Query: 220 KNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHE 279
+ Q++ L+ NE +L +QQ++ Q ++KE E S+++ V L E
Sbjct: 1926 -----QQQLQVLQ----NEIEENKLKLVQQEMMFQRLQKER---ESEESKLETSKVTLKE 1973
Query: 280 KLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEE 339
+ ++LE ++ + S + E+ ++ ++++ + S+E+ L+ TK +
Sbjct: 1974 QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQ------- 2026
Query: 340 IRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEH 399
L E + ++ +K EL ++ D+ F +NQ L + + E + +L E
Sbjct: 2027 -------LSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEA 2079
Query: 400 CSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDL------ 453
+++E+ QE +Q ++ Q + A+ L ++ ++Q +
Sbjct: 2080 LKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQ 2139
Query: 454 ----QKMELLESKMTEEQHSLKSKIK-QMTTDLEIYND-LPALKSSGEEKIKKLHQERMI 507
+ +E + ++++ +LKS++K ++ T L+ N LP L + E +++
Sbjct: 2140 MANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGE 2199
Query: 508 LSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKS 567
L + + M + E + +Q+ + H + L K +H E A +K
Sbjct: 2200 LESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQ 2259
Query: 568 QE 569
E
Sbjct: 2260 AE 2261
Score = 67.0 bits (162), Expect = 5e-11
Identities = 102/531 (19%), Positives = 224/531 (42%), Gaps = 57/531 (10%)
Query: 62 SSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEM 121
+ +IK +T+ + + K + I YLG ++ + ++ E KL+ E
Sbjct: 589 TEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648
Query: 122 YNQENSVYLSYEKRAETLAVEIKELQGQLADY-NMLVDKLNTNTEMEEVMNDYNMLKAQN 180
Q + + E +A++ + ++ +LA+ + L ++ N +++ D + +A+
Sbjct: 649 LLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAEL 708
Query: 181 DRETQSLDVIFTE-RQAKEKQIR-------SVEEEIEQEKQATDDIIKNMSF--ENQVKY 230
+ D + ++ EK R +++ E+E+E+QA + + F E + +
Sbjct: 709 EARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQEN 768
Query: 231 LEMKTTNEKLLQELDTLQQQL-DSQNMKKESLEAEIAHSQVKQEAVLLHEKLY----ELE 285
E+ + L + + L+QQL D QN ++ + +V L KL E+
Sbjct: 769 SELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMN 828
Query: 286 SHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTD----TKEKINQFIEEIR 341
H + KS+ ++ ++L + K + E ER+L + +EK+ EE R
Sbjct: 829 IHSPSDVL-GKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFR 887
Query: 342 Q---------LDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEAN 392
Q ++ D +H+ + Q E+ +E++ + +E + + +L+ + +
Sbjct: 888 QACERALEARMNFDKRQHEARIQQMENEIHYLQENLKS-MEEIQGLTDLQLQEADEEKER 946
Query: 393 IVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTS-------- 444
I+A L R + + +++ +QE L+ + +++K+ +T+ L +
Sbjct: 947 ILAQL----RELEKKKKLEDAKSQEQVF---GLDKELKKLKKAVATSDKLATAELTIAKD 999
Query: 445 DIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDL-------EIYNDLPALKSSGEEK 497
++ L + K+ ++ +E K Q DL E+ +L L+ GE+
Sbjct: 1000 QLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNL--LRQKGEQ- 1056
Query: 498 IKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERK 548
+L E+ + T N+ +EK N E +T++ + LT + K
Sbjct: 1057 -FRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNK 1106
Score = 53.1 bits (126), Expect = 7e-07
Identities = 87/408 (21%), Positives = 184/408 (45%), Gaps = 79/408 (19%)
Query: 214 ATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQ--LDSQNMKKESLEAEIAHSQVK 271
AT+ I + + Q+K +E +E+L + L+ LD+Q E E +I+ +Q +
Sbjct: 399 ATESYIIDSAQAVQIKKME---PDEQLRNDHMNLRGHTPLDTQ---LEDKEKKISAAQTR 452
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKE 331
LH+++ + E + E K + ++ LK+I + +++ + +QL+ +
Sbjct: 453 LSE--LHDEIEKAEQQILRATEEFKQLEEAIQ-----LKKISEAGKDL--LYKQLSGRLQ 503
Query: 332 KINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTF---------IETFEETKNQE 382
+N+ +E L++ +E+ + E+ K KE+K + +D+ ++ + K Q+
Sbjct: 504 LVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQ 563
Query: 383 L----KRKAQIEANIVALLEHCSRNINRIEQISS-------ITNQELKM--------MQD 423
L K+ Q+E+ + +L ++ I+ + N+ LK +Q+
Sbjct: 564 LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQE 623
Query: 424 DLNFKSTEVQKSQSTAQNLTSD----IQRL--------QLDLQKMEL---------LESK 462
L + ++Q+ + L + +QRL QL++ M+ LES
Sbjct: 624 YLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESA 683
Query: 463 MTEEQHSLKSKIKQMTTDLEIYN-DLPA---LKSSGEEKIK-KLHQERMILSTHRNAFKK 517
+ +EQH + + ++Q DL Y +L A L+ + ++K +L + + ++A +
Sbjct: 684 L-QEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQA 742
Query: 518 IMEKQNIEYEALKTQLQE----NETHSQLTNLERKWQHLEQNNFAMKE 561
+EK E +ALK L + E + + L K +HL+ +N +K+
Sbjct: 743 ELEK---ERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQ 787
Score = 44.3 bits (103), Expect = 3e-04
Identities = 78/436 (17%), Positives = 190/436 (43%), Gaps = 56/436 (12%)
Query: 165 EMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSF 224
++E+ M + LK++ R E + ++K +S++EE +KQ+ +++ +++
Sbjct: 278 DLEKKMIETEELKSKQTR-------FLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNT 330
Query: 225 ENQV---KYLEMKTTNEKLLQ-ELDTLQQQLDSQNMKKESLEAEIAH-SQVKQEAVLLHE 279
+N++ K +E+ +K + E + ++D++ +E A + E+ + +
Sbjct: 331 KNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGK 390
Query: 280 KLYELESHRDQMIAEDKSIGSPMEEREKLL---KQIKDDNQEI---ASMERQLTDTKEKI 333
Y+ R+ E I S + K + +Q+++D+ + ++ QL D ++KI
Sbjct: 391 SRYK----RNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKI 446
Query: 334 NQFIEEIRQLDMDLEEHQGEMNQKYKELKKREE--HMDTFIETFEETKNQELKRKAQIEA 391
+ + +L ++E+ + ++ + +E K+ EE + E ++ ++L + Q+
Sbjct: 447 SAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVN 506
Query: 392 NIVALLEHCSRNINRIEQISSITNQELKMMQ---DDLNFKS-----TEVQKS-------- 435
+ + + +Q + +E+K +Q D L+ K + QKS
Sbjct: 507 KLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDI 566
Query: 436 -----QSTAQNLTSDIQRLQLDLQKMELLESKMTEEQ----HSLKSKIKQMTTDLEIY-N 485
Q L + R+ + ++++ LE ++TE Q +LK ++ + + L+ Y
Sbjct: 567 MNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLG 626
Query: 486 DLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNL 545
+ + + + +KL E+ L ++ E+ +E A+ + E L L
Sbjct: 627 TIKGQATQAQNECRKLRDEKETLLQRLTEVEQ--ERDQLEIVAMDAENMRKE----LAEL 680
Query: 546 ERKWQHLEQNNFAMKE 561
E Q + N ++++
Sbjct: 681 ESALQEQHEVNASLQQ 696
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 82.8 bits (203), Expect = 8e-16
Identities = 99/455 (21%), Positives = 191/455 (41%), Gaps = 68/455 (14%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNT 162
S + + T +N L+ +EM Q +E+ E L +I EL + +++KL +
Sbjct: 349 SILKDEVTYMNNLKLKLEMDAQHIKDEFFHER--EDLEFKINELLLAKEEQGCVIEKLKS 406
Query: 163 NTE---------MEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEK-----QIRSVEEEI 208
+E+ + LK Q+ +E L+ F KEK +I+ ++E+
Sbjct: 407 ELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQC 466
Query: 209 EQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHS 268
E +Q + I N E L + ++ LQ +L ++ K S E E
Sbjct: 467 ENLQQEKQEAILNY---------------ESLREIMEILQTEL-GESAGKISQEFESMKQ 510
Query: 269 QVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTD 328
Q + L +KL + +D ++ +++ E EKLL Q + + +E + +
Sbjct: 511 QQASDVHELQQKLRTAFTEKDALL---ETVNRLQGENEKLLSQ----QELVPELENTIKN 563
Query: 329 TKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE-------LKKREEHMDTFIETFEETKNQ 381
+EK ++ + Q D L+E +G++N +E LK E MD F + E +
Sbjct: 564 LQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERL 623
Query: 382 ELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQN 441
L+ ++E I Q +S Q++ + L E ++ +
Sbjct: 624 ILELGKKVEQTI---------------QYNSELEQKVNELTGGLEETLKEKDQNDQKLEK 668
Query: 442 LTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIY---NDLPALKSSGEEKI 498
L ++ L D + + + EE + L S+ KQ++ DLE++ + LK E I
Sbjct: 669 LMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK----EHI 724
Query: 499 KKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQL 533
+L ++ ++ ++ K++E + ++ +KTQL
Sbjct: 725 TQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQL 759
Score = 79.7 bits (195), Expect = 7e-15
Identities = 111/521 (21%), Positives = 223/521 (42%), Gaps = 68/521 (13%)
Query: 108 LTTEVNKLQKGIEMY--NQENSVYLSYEKRAETLAVE------IKELQGQLADYNMLVDK 159
L + +L+K +++ Q+N L ++ + L V+ +KE+ ++++ + D
Sbjct: 720 LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDV 779
Query: 160 LNTNTEMEEVMNDYNMLKA----QNDRETQSLD----VIFTERQAKEKQIRSVEEEIEQE 211
+N + E + N K Q D + L+ + E + ++++S+ + EQE
Sbjct: 780 VNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQE 839
Query: 212 KQATDDIIKNMSFEN---QVKYLEMKTTNEKLLQELDTLQQQLD--SQNMKKESLEAEIA 266
K ++ + E Q LEMK NEK E L Q++ SQ K + E
Sbjct: 840 KVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKE 899
Query: 267 HSQVKQEA---VLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASME 323
+K+ LL +K EL R ++I S+ + L +K+ ++I ++E
Sbjct: 900 KCFIKEHENLKPLLEQK--ELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE 957
Query: 324 RQLTDTKEKINQF----IEEIRQLDMDLEEHQ---GEMNQKYKELKKREEHMDTFIETFE 376
++ + +EKIN+ ++ ++LD +E Q E+ E + M I+ E
Sbjct: 958 KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
Query: 377 ETKNQELKRKAQ-----IEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTE 431
KN L+ + Q +E EH ++ R + S++ + + +DL +
Sbjct: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
Query: 432 VQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALK 491
+Q + + ++QR + + K EL K+ +EQ KIK+ T + +L
Sbjct: 1078 LQSNAKLLEVQILEVQRAKAMVDK-ELEAEKLQKEQ-----KIKEHATTVNELEELQVQL 1131
Query: 492 SSGEEKIKKLHQE--------------RMILSTHRNAFKKIMEK--------QNIEYEAL 529
+++++K QE M ++ + K++ +K +++E E +
Sbjct: 1132 QKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQE-I 1190
Query: 530 KTQLQENET-HSQLTNLERKWQHLEQNNFAMKEFIATKSQE 569
K Q Q+ ET ++T+L+ Q E+ N +K+ + +E
Sbjct: 1191 KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKE 1231
Score = 78.6 bits (192), Expect = 2e-14
Identities = 102/491 (20%), Positives = 224/491 (45%), Gaps = 67/491 (13%)
Query: 111 EVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL---------- 160
EV++ E++N++ ++ + + L +E KEL+ + A+ +L D L
Sbjct: 884 EVSQTCSKSEIHNEKEKCFIKEHENLKPL-LEQKELRDRRAELILLKDSLAKSPSVKNDP 942
Query: 161 -NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT----ERQAKEKQIRSVEEEIEQEKQAT 215
++ E+EE + + + + + + ++ E + K+ ++V+EE+E +
Sbjct: 943 LSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEK 1002
Query: 216 DDIIKNMS--FENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQE 273
D + +M + Y + EK ++LD +++ ++ + E L ++ +S ++ E
Sbjct: 1003 DQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCE 1062
Query: 274 AVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLK-QIKDDNQEIASMERQLTDTKEK 332
+ S + ++A +++ S KLL+ QI + + A ++++L K +
Sbjct: 1063 TI---------NSDNEDLLARIETLQS----NAKLLEVQILEVQRAKAMVDKELEAEKLQ 1109
Query: 333 INQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETK--NQELKRKAQIE 390
Q I+E +LEE Q ++ ++ K+L+K + ++ + ++T N E+ ++
Sbjct: 1110 KEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLM 1169
Query: 391 ANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQ 450
+ L + + I +EQ I Q+ + +Q+++ T +Q S + + I++L
Sbjct: 1170 KELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEI----TSLQSSVQQYEEKNTKIKQLL 1225
Query: 451 LDLQKMELLESKMTEEQH-----SLKSKIKQMTTDLEIYNDLPA------------LKSS 493
+ +K EL +SK E H SLK +++ +E+Y A LK+S
Sbjct: 1226 VKTKK-ELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTS 1284
Query: 494 GEEKIKKL--HQERM-ILSTHRNAFKKIMEKQNIEYEALKTQL------QENETHSQ--L 542
E+ + L +Q+R+ L A K E+E+ K ++ Q+N++ SQ
Sbjct: 1285 AEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAET 1344
Query: 543 TNLERKWQHLE 553
+++ +HLE
Sbjct: 1345 EGAKQEREHLE 1355
Score = 66.6 bits (161), Expect = 6e-11
Identities = 118/495 (23%), Positives = 199/495 (40%), Gaps = 110/495 (22%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
++ ++ + T++ K +E +++Y K E L E+ ++ + ++ DK
Sbjct: 102 MKQEVEDSVTKMGDAHKELEQS------HINYVKEIENLKNELMAVRSKYSE-----DKA 150
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIK 220
N ++EE MN L Q + S E ++ ++EEIE+ +
Sbjct: 151 NLQKQLEEAMNTQLELSEQLKFQNNS-----------EDNVKKLQEEIEKIRP------- 192
Query: 221 NMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEK 280
FE Q+ Y LQ+QLD A + K+E V +
Sbjct: 193 --GFEEQILY----------------LQKQLD-------------ATTDEKKETVTQLQN 221
Query: 281 LYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEI 340
+ E S Q K+I S EE L Q+K +QE + E +
Sbjct: 222 IIEANSQHYQ-----KNINSLQEE----LLQLKAIHQE----------------EVKELM 256
Query: 341 RQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHC 400
Q++ +EH+ E+N K ELK E++ E E KN + K + ++E L
Sbjct: 257 CQIEASAKEHEAEIN-KLNELK---ENLVKQCEASE--KNIQKKYECELEN-----LRKA 305
Query: 401 SRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLE 460
+ N N+ QI SI QE ++ +N K V+ + T + L S L+ ++ M L+
Sbjct: 306 TSNANQDNQICSILLQENTFVEQVVNEK---VKHLEDTLKELESQHSILKDEVTYMNNLK 362
Query: 461 SKMTEEQHSLKSKIKQMTTDLEI-YNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIM 519
K+ + +K + DLE N+L K I+KL E L+ F +
Sbjct: 363 LKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSE---LAGLNKQFCYTV 419
Query: 520 EKQNIEYEALKTQLQE-----NETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQP 574
E+ N E ++LK Q Q+ NET L++ E++ L +KE QE
Sbjct: 420 EQHNREVQSLKEQHQKEISELNETF--LSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAI 477
Query: 575 IKKNVTKQIAEYNKT 589
+ ++I E +T
Sbjct: 478 LNYESLREIMEILQT 492
Score = 60.8 bits (146), Expect = 3e-09
Identities = 77/409 (18%), Positives = 175/409 (42%), Gaps = 57/409 (13%)
Query: 225 ENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYEL 284
E +++ L K E + L ++LD+ ++K ++ +Q+ + L ++ ++
Sbjct: 52 EKEIEELRSKPVTEGTGDIIKALTERLDALLLEK---------AETEQQCLSLKKENIKM 102
Query: 285 ESHRDQMIAEDKSIGSPMEERE-KLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQL 343
+ + + + +E+ +K+I++ E+ ++ + ++ K + + +EE
Sbjct: 103 KQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNT 162
Query: 344 DMDLEEHQGEMNQKYKELKKREEHMDTFIETFEE-----------TKNQELKRKAQIEAN 392
++L E N +KK +E ++ FEE T +++ + Q++
Sbjct: 163 QLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNI 222
Query: 393 IVALLEHCSRNINRIE----QISSITNQELK--MMQDDLNFK--STEVQKSQSTAQNLTS 444
I A +H +NIN ++ Q+ +I +E+K M Q + + K E+ K +NL
Sbjct: 223 IEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVK 282
Query: 445 DIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSG-----EEKIK 499
+ + ++QK E + + S ++ Q+ + L N + E+ +K
Sbjct: 283 QCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK 342
Query: 500 KLHQERMILS---THRNAFKKIM-------------EKQNIEYEALKTQLQENETHSQLT 543
+L + IL T+ N K + E++++E++ + L + E +
Sbjct: 343 ELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIE 402
Query: 544 NLERKWQHLEQNNFAMKEFIATKSQES-DYQPIKKNVTKQIAEYNKTIV 591
L+ + L K+F T Q + + Q +K+ K+I+E N+T +
Sbjct: 403 KLKSELAGLN------KQFCYTVEQHNREVQSLKEQHQKEISELNETFL 445
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 82.4 bits (202), Expect = 1e-15
Identities = 120/538 (22%), Positives = 230/538 (42%), Gaps = 102/538 (18%)
Query: 94 KSYYLGLLRSKISE--LTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLA 151
+S YL + + K + L E +LQK + EN + ++ AET I EL+ L
Sbjct: 519 QSEYLKISQEKEQQESLALEELELQKKAILTESENKLR-DLQQEAETYRTRILELESSLE 577
Query: 152 DYNMLVDKLNTNTEM----EEVMNDYN----MLKAQNDRETQSL----DVIFTER----- 194
L + N + ++ E N +N ++ ++ E +SL D ++TE+
Sbjct: 578 --KSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLK 635
Query: 195 QAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQ 254
Q + ++ + E+ EQEK+ ++K+ Q EM NEK L++LD Q +L
Sbjct: 636 QQYQTEMEKLREKCEQEKET---LLKDKEIIFQAHIEEM---NEKTLEKLDVKQTEL--- 686
Query: 255 NMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKD 314
ESL +E+ S+V + L E+L L+ D+M E + + M+E++ +Q D
Sbjct: 687 ----ESLSSEL--SEVLKARHKLEEELSVLKDQTDKMKQE---LEAKMDEQKNHHQQQVD 737
Query: 315 D--NQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFI 372
+ S++R K++INQ +++ D L+EHQ + ++K+ E
Sbjct: 738 SIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE----- 792
Query: 373 ETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDL-----NF 427
L+ S ++ + S T+++ K ++ L
Sbjct: 793 ------------------------LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Query: 428 KSTEVQKSQSTAQNLTSDIQR----LQLDLQKMEL--LESKMTEEQHSLKSKIKQMTTDL 481
E ++ T Q + Q+ +LD K+++ L ++ ++ ++ K+K +T
Sbjct: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLT--- 885
Query: 482 EIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQ------- 534
++Y +S E+ K+ Q + IL N ++ E Q E E L +L
Sbjct: 886 QVY------ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
Query: 535 --ENETHSQLTNLERKWQHLEQNNFAMKEFIATK--SQESDYQPIKKNVTKQIAEYNK 588
E ++ N E+K + ++Q M+E + K QE+ + +N ++++ K
Sbjct: 940 ILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997
Score = 79.0 bits (193), Expect = 1e-14
Identities = 117/546 (21%), Positives = 236/546 (43%), Gaps = 65/546 (11%)
Query: 98 LGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLV 157
L R K SEL T LQ+ E + + S +K +A +ELQ L
Sbjct: 150 LSSYRGKYSELVTAYQMLQR--EKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQ 207
Query: 158 DKLNTNTEMEE-----VMNDYNMLKAQNDRETQSLDVIFTERQAK-EKQIRSVEEEIEQE 211
++ + + E ++ + ++LK + ++DV+ Q + + ++ + EE E +
Sbjct: 208 EEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESD 267
Query: 212 KQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK 271
+ E+ ++T +++ ++ + L++ ++ KE + +
Sbjct: 268 GEPV--------VEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEAL 319
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDD-NQEIASMERQLTDT- 329
QE L E+L ELE +D +AE + + + + + L++Q++ D IA +RQ+ +T
Sbjct: 320 QEQ--LDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL 377
Query: 330 ---KEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRK 386
+E+I Q I+Q+ EE + QK K + E ++ + T ++T+ K K
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEELR---EQKEKSERAAFEELEKALSTAQKTEEARRKLK 434
Query: 387 AQIEANI-----------VALLEHCSRNINRIEQISSITNQE-----LKMMQDDLNFKST 430
A+++ I ++L + SR + + +++E K+ + +L K
Sbjct: 435 AEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494
Query: 431 EVQKSQSTAQNLTSDIQRLQLDLQKMELLE-SKMTEEQHSL----------------KSK 473
E+ K T + + ++ L+ + E L+ S+ E+Q SL ++K
Sbjct: 495 ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENK 554
Query: 474 IKQMTTDLEIYND-LPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQ-NIEYEALKT 531
++ + + E Y + L+SS E+ +++ + L+ H A K K+ + E KT
Sbjct: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614
Query: 532 QLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIK-KNVTKQ--IAEYNK 588
+L E+ H Q K Q L+Q E + K ++ +K K + Q I E N+
Sbjct: 615 EL-ESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNE 673
Query: 589 TIVDAL 594
++ L
Sbjct: 674 KTLEKL 679
Score = 73.9 bits (180), Expect = 4e-13
Identities = 107/522 (20%), Positives = 232/522 (44%), Gaps = 70/522 (13%)
Query: 101 LRSKISELTTEVNKLQK----GIEMYNQENSVYLSYEKRAETLAVE----IKELQGQLAD 152
L ++ +L+ +V+ L K +E + ++ + ++K+A++ + +KELQ QL
Sbjct: 1410 LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE- 1468
Query: 153 YNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEK 212
+ E E N+LK + D++ + D + E + + ++ E +E E
Sbjct: 1469 --------LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Query: 213 QATDDIIKNMSFENQVKYLEMKTTNEKLL---QELDTLQQQLDS--QNMKKESLEAEIAH 267
++ I + K +E+++ NE L Q+ D ++L Q+ ++ E +
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Query: 268 SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQ-----EIASM 322
+ +++ + L ++Y +++ + E + + ++ +E+ LK ++D + ++A +
Sbjct: 1581 KEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAEL 1640
Query: 323 ERQLTDT-----KEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEE 377
+R+ K+ ++Q E+ Q E H E+N K +E ++ ++ +++ E
Sbjct: 1641 KRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700
Query: 378 TKNQEL--KRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQK- 434
++++ L R A+ N+ A E + + +++ ++Q +L K +Q+
Sbjct: 1701 SQSETLIVPRSAK---NVAAYTE--QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRV 1755
Query: 435 SQSTAQNLTSDIQ---RLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALK 491
Q + ++S + + Q L K+E E+K QH +S I + +L
Sbjct: 1756 GQEKEETVSSHFEMRCQYQERLIKLEHAEAK----QHEDQSMIGHLQEEL---------- 1801
Query: 492 SSGEEKIKKLHQERMILSTH---RNAFKKIMEKQNIE--YEALKTQLQENETHSQLTNLE 546
EEK KK +I++ H I KQN+E ++ ++ LQE E Q+ LE
Sbjct: 1802 ---EEKNKKY---SLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI--LE 1853
Query: 547 RKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNK 588
+K + L+ KE + +E + K +Q+ NK
Sbjct: 1854 QKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNK 1895
Score = 73.6 bits (179), Expect = 5e-13
Identities = 95/469 (20%), Positives = 213/469 (45%), Gaps = 48/469 (10%)
Query: 163 NTEMEEVMNDYNML-KAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
++E E+++ + + L K Q + + ++ + + K ++ + + +++EK+ I+
Sbjct: 121 DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQ 180
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKES----LEAEIAHSQVKQEA--- 274
++ + E++ + Q LQ++ D+ +K+ L+ ++ S +KQ
Sbjct: 181 SQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQV--SLLKQRLRNG 238
Query: 275 ---VLLHEKLYELESHRDQMIAED--KSIGSPMEEREKLLKQIKDDNQEIASMERQLTDT 329
V + + L +LE + E+ +S G P+ E +K ++ Q + E L
Sbjct: 239 PMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRC 298
Query: 330 KEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKK-REEHM-------------DTFIETF 375
KE I E+ L + E Q +++++ +EL+K ++ HM IE
Sbjct: 299 KETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQL 358
Query: 376 EETKNQEL-KRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQK 434
E+ K + + K Q+ + E ++ +RI+Q+++ + + + E++K
Sbjct: 359 EQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEK 418
Query: 435 SQSTAQNLTSDIQRLQLDL-QKMELLESKMTEEQHSLK---SKIKQMTTDLEIYNDLPAL 490
+ STAQ ++L+ ++ ++++ +E EE+ SL+ S++KQ D+ +
Sbjct: 419 ALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDV--------M 470
Query: 491 KSSGEEKIKKLHQ--ERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERK 548
K S EE+I KL + E+ + + KK+ ++ E +K L+++++ + E++
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKE 530
Query: 549 WQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHST 597
+Q + A++E K K +Q AE +T + L S+
Sbjct: 531 ----QQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESS 575
Score = 72.8 bits (177), Expect = 9e-13
Identities = 108/556 (19%), Positives = 229/556 (41%), Gaps = 79/556 (14%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q Q+ KS ++ L ++L + KL+ + +EN+ + LA E K
Sbjct: 1112 QEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKV 1171
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
+L KL T E ++ LK+ +++ +SL+ K + + + EE
Sbjct: 1172 SELTS------KLKTTDE------EFQSLKSSHEKSNKSLE-------DKSLEFKKLSEE 1212
Query: 208 IEQE------------KQATDDII-----KNMSFENQVKYLEMKTTNEKLLQELDTLQQQ 250
+ + + T+++I K + +++ + + +TT K +
Sbjct: 1213 LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVK---------EA 1263
Query: 251 LDSQNMKKESLEAEIAHSQVKQEA--VLLHEKLYELESHRDQMIAEDKSIGSPMEEREKL 308
L + LEA++ +Q + + ++LE +Q+ + I S + E+E L
Sbjct: 1264 LLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL 1323
Query: 309 LKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHM 368
K+ + Q + E +T K+++++ I + + +L+E + E++ K+L +
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Query: 369 DTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFK 428
I E+ RK Q + LL+ +++ +S L+ + D N
Sbjct: 1384 QNSISLSEKEAAISSLRK-QYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Query: 429 STEVQKSQSTAQNLTSDIQRLQLDL-----------QKMELLESKMTE----------EQ 467
S +K+QS + ++ LQ+ L +++ LL+ ++ + E
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
Query: 468 HSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYE 527
KSK+++ ++LE +L + + E + Q+ + + + K ++++IE++
Sbjct: 1503 EDDKSKMEKKESNLE--TELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK 1560
Query: 528 ALKTQLQE-----NETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQ 582
L +LQ E +++ E K LE ++MK + TK +E ++ + K
Sbjct: 1561 ELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS---VKS 1617
Query: 583 IAEYNKTIVDALHSTS 598
E K + D L S S
Sbjct: 1618 KEEELKALEDRLESES 1633
Score = 66.6 bits (161), Expect = 6e-11
Identities = 102/517 (19%), Positives = 211/517 (40%), Gaps = 74/517 (14%)
Query: 102 RSKISELTTEVNKLQKGIEMYNQE-NSVYLSYEKRAETLAVEIKELQG----QLADYNML 156
+ +I LT +++ + I + N+E + + + EK+ E + + KE+Q +L D
Sbjct: 921 KKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK 980
Query: 157 VDKLNTNTEME----EVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEK 212
+ K NT +E E + ML+ D + +++QI S+ E +E
Sbjct: 981 LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRE- 1039
Query: 213 QATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQ 272
+D+I +KL Q+ + LQ+ + Q +KE AE+ KQ
Sbjct: 1040 --LNDVIS--------------IWEKKLNQQAEELQEIHEIQLQEKEQEVAEL-----KQ 1078
Query: 273 EAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEK 332
+ +L + E+ + E + + E ++ LKQ +A E +L EK
Sbjct: 1079 KILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEK 1138
Query: 333 I----------NQFI-EEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQ 381
+ N F+ E++ +L M EE + ++++ +LK +E + +++ E N+
Sbjct: 1139 LEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS-LKSSHEKSNK 1197
Query: 382 ELKRKA----QIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQS 437
L+ K+ ++ + L+ C + + + + TN+ + + N + + Q
Sbjct: 1198 SLEDKSLEFKKLSEELAIQLDICCKKTEAL--LEAKTNELINISSSKTNAILSRISHCQH 1255
Query: 438 TAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEK 497
+ + + ++E ++TEEQ++L +Q T LE
Sbjct: 1256 RTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE--------------- 1300
Query: 498 IKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNF 557
+E I S + + EK+ ++ E Q +E S +T L+++
Sbjct: 1301 ----EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
Query: 558 AMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDAL 594
MKE + K E +++KQ+ + N + +++
Sbjct: 1357 LMKEELKEKKVEI------SSLSKQLTDLNVQLQNSI 1387
Score = 61.2 bits (147), Expect = 3e-09
Identities = 85/380 (22%), Positives = 171/380 (45%), Gaps = 43/380 (11%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAV---EIK 144
Q ++ +K+ L+ ++ E N +Q + N + V + +++ T + +IK
Sbjct: 1798 QEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIK 1857
Query: 145 ELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSV 204
EL D ++ K EMEE+ + Y L+A + ++ E +EK
Sbjct: 1858 EL-----DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKS---- 1908
Query: 205 EEEIEQEKQATDDIIKNMSFEN---QVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESL 261
+ + Q K ++ NM ++ + K + +KL +E+ LQ+ L + ++KE
Sbjct: 1909 KSHLVQPK-----LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL--RMLRKEH- 1960
Query: 262 EAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIAS 321
+QE +L + E + R++ I +++ ++ L + +++ N ++A
Sbjct: 1961 ---------QQELEILKK---EYDQEREEKIKQEQE-DLELKHNSTLKQLMREFNTQLAQ 2007
Query: 322 MERQLTDT-KEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKN 380
E++L T KE IN+ E +L LE HQ E NQ K++ ++++ + + +EE +
Sbjct: 2008 KEQELEMTIKETINKAQEVEAEL---LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILD 2064
Query: 381 -QELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMM--QDDLNFKSTEVQKSQS 437
+E + A++ L E + ++EQ + N + +M Q L K+T + S+
Sbjct: 2065 AREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKL 2124
Query: 438 TAQNLTSDIQRLQLDLQKME 457
Q I L+ L+K E
Sbjct: 2125 KEQEFREQIHNLEDRLKKYE 2144
Score = 60.1 bits (144), Expect = 6e-09
Identities = 97/501 (19%), Positives = 206/501 (41%), Gaps = 63/501 (12%)
Query: 97 YLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAV--------------- 141
+L L +K+ E EV+ L++ ++ S L + A+ +A
Sbjct: 1673 HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK 1732
Query: 142 ----EIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAK 197
+I LQ L + L+ ++ E EE ++ + ++ Q L+ ++
Sbjct: 1733 TYEEKISVLQRNLTEKEKLLQRVGQ--EKEETVSSHFEMRCQYQERLIKLEHAEAKQHED 1790
Query: 198 EKQIRSVEEEIEQEKQATDDII-KNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNM 256
+ I ++EE+E++ + I+ +++ E ++ K E + D +Q+ L + +
Sbjct: 1791 QSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVF---DDVQKTLQEKEL 1847
Query: 257 KKESLEAEI------------AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE 304
+ LE +I H +E +EKL L+ QM +K E
Sbjct: 1848 TCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ----QMDGRNKPTELLEEN 1903
Query: 305 REKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKR 364
E+ K + +++ME Q D + K+ E ++L ++ Q ++ KE
Sbjct: 1904 TEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE---H 1960
Query: 365 EEHMDTFIETFEETKNQELKRKAQ-IEANIVALLEHCSRNINRIEQISSITNQELKMMQD 423
++ ++ + +++ + +++K++ + +E + L+ R N Q++ QEL+M
Sbjct: 1961 QQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNT--QLAQ-KEQELEMTIK 2017
Query: 424 DLNFKSTEVQKS-----QSTAQNLTSDIQRLQLDLQKM-ELLESKMTEEQHSLKSKIKQM 477
+ K+ EV+ Q L I DL++ + E + + + +K++ +
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL 2077
Query: 478 TTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENE 537
T LE K EE + M L T ++ +K + ++ +L+E E
Sbjct: 2078 QTQLEELQKKYQQKLEQEENPGNDNVTIMELQT------QLAQKTTLISDS---KLKEQE 2128
Query: 538 THSQLTNLERKWQHLEQNNFA 558
Q+ NLE + + E+N +A
Sbjct: 2129 FREQIHNLEDRLKKYEKNVYA 2149
>gi|153791839 sodium channel associated protein 1 [Homo sapiens]
Length = 688
Score = 82.4 bits (202), Expect = 1e-15
Identities = 113/515 (21%), Positives = 220/515 (42%), Gaps = 78/515 (15%)
Query: 112 VNKLQKGIEMYNQENS------------------VYLSYEKRAETLAVEIKELQGQLADY 153
V LQ+ +++ NQE + +Y + A+ E ++ + QL D+
Sbjct: 130 VRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDF 189
Query: 154 NMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQ 213
L +L+ E EV N LK ++ + RQAK ++R ++E+
Sbjct: 190 QQLTKQLHVTNENMEVTNQ-QFLKTVTEQSVIIEQLRKKLRQAK-LELRVAVAKVEELTN 247
Query: 214 ATDDIIKNMSFENQ--VKYLEMKTTNEKLLQELDTLQQQLDSQNMK--KESLEAEIAHSQ 269
T+D+ M + + V + +++ LQ+L + +QL+ + +E+ + ++
Sbjct: 248 VTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTH 307
Query: 270 VKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE----REKLLKQIKDDNQEIASME-- 323
++++ L K ELE+ R + I ++ +EE + + L + K ++I M+
Sbjct: 308 LEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKET 367
Query: 324 -------------RQLTDTKEKIN----QFIEEIRQLDMDLEEHQGEMNQKYKELKKREE 366
+++ +TK++ N + EE+ L M+ E QG++ + KE K EE
Sbjct: 368 VSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEE 427
Query: 367 HMDTFIETFEETKNQELKRKAQIEANIVA------LLEHCSRNINRIEQISSITNQELKM 420
++ ++ K + + +V+ L +R NRI+Q+ + +++E+
Sbjct: 428 ELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISR 487
Query: 421 MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMEL------LESKMTEEQHSLKSKI 474
Q+ + K V +S+ L S+ QRL+L + +L L E Q K KI
Sbjct: 488 YQEMIQ-KLQNVLESERENCGLVSE-QRLKLQQENKQLRKETESLRKIALEAQKKAKVKI 545
Query: 475 KQMTTDLEIYN-----DLPALKSSGEEKIKKLHQERMILSTHRNA-------FKKIMEKQ 522
M + I L ++ S I +L R +L+T + A KK+ E
Sbjct: 546 STMEHEFSIKERGFEVQLREMEDSNRNSIVEL---RHLLATQQKAANRWKEETKKLTESA 602
Query: 523 NIEYEALKTQLQENETHSQ--LTNLERKWQHLEQN 555
I LK++L + H+Q L+ LE + + +N
Sbjct: 603 EIRINNLKSELSRQKLHTQELLSQLEMANEKVAEN 637
Score = 62.8 bits (151), Expect = 9e-10
Identities = 102/478 (21%), Positives = 198/478 (41%), Gaps = 85/478 (17%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSY------EKRAETLAVEIKELQGQLADYNML 156
+K+ ELT LQ +M +E V ++ ++R + L IK+L+ +L
Sbjct: 240 AKVEELTNVTEDLQG--QMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQE 297
Query: 157 VDKLNT-NTEMEEVMNDYNMLKAQ-NDRETQSLDVIFTER---QAKEKQIRSVEEEIEQE 211
++L T NT +E+ + L+A+ N+ E + + I R Q E+ + + +E
Sbjct: 298 ANQLRTENTHLEKQTRE---LQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEE 354
Query: 212 KQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK 271
KQ +DI K MK T + +Q+ T++ + + N KK+ I S++
Sbjct: 355 KQKEEDIEK------------MKETVSRFVQDA-TIRTKKEVANTKKQ---CNIQISRLT 398
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE-------REKLLKQIKDDNQEIASMER 324
+E L + E + +++I E K++ +E+ E +++++ +Q ER
Sbjct: 399 EELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSER 458
Query: 325 QLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKK------------REEHMDTFI 372
D + ++ + I+QL+ D E + ++L+ E+ +
Sbjct: 459 SKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQ 518
Query: 373 ETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQ----ELKMMQDDLNFK 428
E + K E RK +EA A ++ I+ +E SI + +L+ M+D
Sbjct: 519 ENKQLRKETESLRKIALEAQKKAKVK-----ISTMEHEFSIKERGFEVQLREMEDSNRNS 573
Query: 429 STEVQKSQSTAQ----------------------NLTSDIQRLQLDLQKMELLESKMTEE 466
E++ +T Q NL S++ R +L Q++ L + +M E
Sbjct: 574 IVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQEL-LSQLEMANE 632
Query: 467 QHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNI 524
+ + K+ + E N L S EE+ Q+ +++ R +M +NI
Sbjct: 633 KVAENEKL--ILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASLMNLENI 688
Score = 41.2 bits (95), Expect = 0.003
Identities = 68/370 (18%), Positives = 146/370 (39%), Gaps = 49/370 (13%)
Query: 92 LDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEI-------- 143
L+ Y ++R++ S E LQK + +E EK ET++ +
Sbjct: 322 LENERYEAIVRARNSMQLLEEANLQKSQALL-EEKQKEEDIEKMKETVSRFVQDATIRTK 380
Query: 144 KELQGQLADYNMLVDKLNTNT-----EMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKE 198
KE+ N+ + +L E E + + + L+ I+ E + E
Sbjct: 381 KEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNE 440
Query: 199 KQIRSVEEEIEQ---EKQATDDI-IKNMSFENQVKYLEMKTTNE--KLLQELDTLQQQLD 252
R +EE ++ +++ DD+ ++ EN++K LE ++ E + + + LQ L+
Sbjct: 441 SDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLE 500
Query: 253 SQN-----MKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIA-------------- 293
S+ + ++ L+ + + Q+++E L + E + I+
Sbjct: 501 SERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFE 560
Query: 294 ------EDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDL 347
ED + S +E R L Q K N+ ++ + +IN E+ + +
Sbjct: 561 VQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHT 620
Query: 348 EEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRI 407
+E ++ +++ + E+ I +E N+ +R +Q E + + S +
Sbjct: 621 QELLSQLEMANEKVAENEK----LILEHQEKANRLQRRLSQAEERAASASQQLSVITVQR 676
Query: 408 EQISSITNQE 417
+ +S+ N E
Sbjct: 677 RKAASLMNLE 686
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/561 (20%), Positives = 252/561 (44%), Gaps = 73/561 (13%)
Query: 87 PQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKEL 146
P+++ L + + L + +++EL +E K + I ++ S+ + E E+++
Sbjct: 19 PRQEELADNLLISLSKVEVNELKSE--KQENVIHLFRITQSLMKMKAQEVELALEEVEKA 76
Query: 147 QGQLADYNMLVDKLNTNTEMEEVMNDYNMLK-AQNDRETQSL--DVIFTERQA--KEKQI 201
+ A + + T++ ++ N+ M + + R+T+ L ++ E+Q K++++
Sbjct: 77 GEEQAKFENQL-----KTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDREL 131
Query: 202 RSVEEEIEQEKQATDDI-IKNMSFENQVKYLE-----MKTTNEKLLQELDTLQQQLDSQN 255
+E+E+E+EK+ + + ++N EN+ L +K NE+L Q++ Q+Q+DSQ
Sbjct: 132 EDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQ- 190
Query: 256 MKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDD 315
K+ L S + + L +K YEL + D++ ++ + +++ K +++
Sbjct: 191 -KETLLSRRGEDSDYRSQ---LSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEES 246
Query: 316 NQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFI--- 372
QE+ M + K ++Q I QL + + +Q ++ + LK + E D +
Sbjct: 247 VQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAV 306
Query: 373 -------ETFEETKNQELKRKAQIEANI-----VALLEHCSRNINRIEQISSITNQELKM 420
+ +K+ E+ Q+ N+ A L+ N+ ++Q + ++KM
Sbjct: 307 NAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKM 366
Query: 421 MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQ----------------LDLQKMELLESKMT 464
+ + + + E++K+ ++L +++QR + LD+ K + E++ T
Sbjct: 367 LTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERT 426
Query: 465 EE--QHSLKSKIKQMTTDLEIYNDLPA-----------LKSSGEEKIKKLHQERMILSTH 511
E + + K K++ L+ D + +K+ + +IK +E IL+
Sbjct: 427 AELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNC-KNQIKIRDREIEILTKE 485
Query: 512 RNAFKKIMEKQNIEYEALKTQL-QENETHSQLTNLERKWQHLEQNNFAMKEFIATK---S 567
N + + E EAL+ ++ E +T LT R +HL+Q + + I K S
Sbjct: 486 INKLELKISDFLDENEALRERVGLEPKTMIDLTEF-RNSKHLKQQQYRAENQILLKEIES 544
Query: 568 QESDYQPIKKNVTKQIAEYNK 588
E + +KK + + E K
Sbjct: 545 LEEERLDLKKKIRQMAQERGK 565
Score = 67.8 bits (164), Expect = 3e-11
Identities = 115/554 (20%), Positives = 239/554 (43%), Gaps = 92/554 (16%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQ-------ENSVYLSY-EKRAETLAVEIKELQGQLAD 152
L+ K +L ++ QK I+ + E+S Y S K+ L + E+Q L +
Sbjct: 169 LKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQ-TLTE 227
Query: 153 YNMLVDKLNTNT---------EMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRS 203
N ++ N EME++ ++YN +KA + +D + E + Q++
Sbjct: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQE 287
Query: 204 VEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDS--QNMKKESL 261
+ + ++ + + D I+ ++ + + L + + ++++++ QQ L + + +K L
Sbjct: 288 LTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIE----YQQMLHNLREKLKNAQL 343
Query: 262 EAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDD---NQE 318
+A+ K + L + + E +S + + + ME+ +++ +K++ N+
Sbjct: 344 DAD------KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKG 397
Query: 319 IASMERQ--------LTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDT 370
+++ +Q L KEK + + D E E+ + K LK E +
Sbjct: 398 ASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYG 457
Query: 371 FIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIE-QISSITNQ----------ELK 419
+ E KN K + +I + +L ++ IN++E +IS ++ E K
Sbjct: 458 LEDAVVEIKN--CKNQIKIRDREIEIL---TKEINKLELKISDFLDENEALRERVGLEPK 512
Query: 420 MMQDDLNFK-STEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQM- 477
M D F+ S +++ Q A+N Q+ L+++E LE EE+ LK KI+QM
Sbjct: 513 TMIDLTEFRNSKHLKQQQYRAEN--------QILLKEIESLE----EERLDLKKKIRQMA 560
Query: 478 -------------TTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAF--KKIMEKQ 522
T DL + ++ E K+ L + M + +N F ++++EK+
Sbjct: 561 QERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKE 620
Query: 523 NIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQ 582
+ E +T + + + ++L L + + LE+ MKE + + +K T
Sbjct: 621 R-DLERSRTVIAKFQ--NKLKELVEENKQLEE---GMKEILQAIKEMQKDPDVKGGETSL 674
Query: 583 IAEYNKTIVDALHS 596
I + +V+A+ S
Sbjct: 675 IIPSLERLVNAIES 688
Score = 62.8 bits (151), Expect = 9e-10
Identities = 90/471 (19%), Positives = 204/471 (43%), Gaps = 68/471 (14%)
Query: 93 DKSYYLGLLRSKISELTTEVNKLQKGIEMYNQE----NSVYLSYEKRAETLAVEIKELQG 148
D+ L L ++++ EL EV+KL++ ++ ++ N+ S +K E+L +++ + Q
Sbjct: 1134 DRQRILELEKNEM-ELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192
Query: 149 QLADYNML-----------------VDKLNTNTEMEEVMNDYNM-LKAQNDRETQSLDVI 190
Q + +++ + KL + T + M YN+ L+ + D + Q+L
Sbjct: 1193 QSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYA 1252
Query: 191 FTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQ 250
E + + K +R + + ++ + + F + ++++ K++QE+ QQ+
Sbjct: 1253 RLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTM--IQLQNDKLKIMQEMKNSQQE 1310
Query: 251 LDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLK 310
+NM+ ++LE E+ +++ L + + M E+ + + KL +
Sbjct: 1311 --HRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRL-----QELKLNR 1363
Query: 311 QIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDT 370
++ D +EI + +++ + I+ EEI Q + EE Q +Q+ +L+++
Sbjct: 1364 ELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQ------ 1417
Query: 371 FIETFEETKNQELKRKAQIEANIVAL----------LEHCSRNINRIEQISSITNQELKM 420
++ F+ +N+ L + E ++ LE R I +I T K
Sbjct: 1418 -LDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKS 1476
Query: 421 MQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDL------QKM--ELLESKMTEEQH---- 468
+++ L K + ++ ++ + I L+L L +K+ EL +M + H
Sbjct: 1477 LEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLK 1536
Query: 469 -------SLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHR 512
++++++ Q L+ Y L + +I K H+E + + HR
Sbjct: 1537 IAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHR 1587
Score = 58.5 bits (140), Expect = 2e-08
Identities = 70/339 (20%), Positives = 149/339 (43%), Gaps = 36/339 (10%)
Query: 71 PVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRS-KISELTTEVNKLQKGIE-----MYNQ 124
P ++ + MK + QR+ G+L S K++ + E KL+ +E + +Q
Sbjct: 2128 PELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQ 2187
Query: 125 ENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQND--- 181
+ Y S K E + E + L+ +L +KL E++N+ ++ +
Sbjct: 2188 LSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKR 2247
Query: 182 -------------RETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQV 228
+++S I R + K ++ +E +I ++ Q+ D+ K + E
Sbjct: 2248 LQFAESRGPQLEGADSKSWKSIVVTRMYETK-LKELETDIAKKNQSITDL-KQLVKEATE 2305
Query: 229 KYLEMKTTNEKLLQELDTLQQQLDS----QNMKKESLEAEIAHSQVKQEAVLLHEKLYEL 284
+ ++ NE L Q++ L+ + Q +K+E +A+ Q+ +E E ++++
Sbjct: 2306 REQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKA---ELIHQI 2362
Query: 285 ESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLD 344
E+++DQ AE S + + ++L ++IKD ++ + + KE+I + +E+ D
Sbjct: 2363 EANKDQSGAE-----STIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFD 2417
Query: 345 MDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQEL 383
E ++ YKE K+ ++ ++ E EL
Sbjct: 2418 PSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVEL 2456
Score = 55.1 bits (131), Expect = 2e-07
Identities = 104/565 (18%), Positives = 221/565 (39%), Gaps = 86/565 (15%)
Query: 66 KVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQE 125
+V P T LT + Q+Q ++ +L +I L E L+K I QE
Sbjct: 506 RVGLEPKTMIDLTEFRNSKHLKQQQYRAENQ---ILLKEIESLEEERLDLKKKIRQMAQE 562
Query: 126 NSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDY----NMLKAQND 181
KR+ T + ++L L + ++ + E D NM +AQ+
Sbjct: 563 RG------KRSATSGLTTEDLN--------LTENISQGDRISERKLDLLSLKNMSEAQSK 608
Query: 182 RETQSLDVIFTERQAKEKQI------RSVEEEIEQEKQATDDI------IKNMSFENQVK 229
E S ++I ER + + ++E +E+ KQ + + IK M + VK
Sbjct: 609 NEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVK 668
Query: 230 YLEMKT---TNEKLLQELDT------------LQQQLDSQNMKKESLEAEIAHSQVKQEA 274
E + E+L+ +++ L+ Q+D + E L E+ S ++EA
Sbjct: 669 GGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRES--RKEA 726
Query: 275 VLLHEKLYELESHRDQMIAED-------------KSIGSPMEEREKLLKQIKDDNQEIAS 321
+ ++L + D + E K I P I N+ +
Sbjct: 727 INYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIH 786
Query: 322 MERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQ 381
+ ++L + ++K+ + + + + + + YKE +E T +T +E K
Sbjct: 787 LLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKR- 845
Query: 382 ELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQN 441
K + Q++ + + + E+ N + + + E+K + + + K T +Q ++ +
Sbjct: 846 --KLEDQVQQDAIKVKEY-----NNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIR 898
Query: 442 LTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKL 501
+ + L+ L+K K E S+++++ + L+ + ++ K + +K+
Sbjct: 899 QYTTLVELERQLRKEN---EKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKV--- 952
Query: 502 HQERMILSTHRNAFKKIMEKQNIEYEALKTQLQEN-ETHSQLTNLERKWQHLEQNNFAMK 560
+ +E N +Y L + ++ + + L +HLE N ++K
Sbjct: 953 --------VDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLK 1004
Query: 561 EFIATKSQESDYQPIKKNVTKQIAE 585
E + + ++E + K + +Q E
Sbjct: 1005 EQVESINKELEITKEKLHTIEQAWE 1029
Score = 53.9 bits (128), Expect = 4e-07
Identities = 98/484 (20%), Positives = 210/484 (43%), Gaps = 105/484 (21%)
Query: 200 QIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNE--KLLQELDTLQQQLDSQNMK 257
+++ V +++E++++ T+ +K FEN L+ +E K+ E++ L+ LD +
Sbjct: 1643 KLKKVSQDLERQREITE--LKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKE 1700
Query: 258 KESLEAEIAHSQVKQEA-------------------VLLHEKLYE------LESHRDQMI 292
+ L++E+ Q ++EA + L EK + LE +
Sbjct: 1701 SQCLKSEL---QAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTA 1757
Query: 293 AEDKSIGSPMEERE--------------KLLKQIKDDNQEIASMERQLTDTKEKINQFIE 338
A ++ I S ++E +L Q++D N+ + ++ L +K + N +
Sbjct: 1758 AAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTD 1817
Query: 339 EIRQLDMDLEEHQG----------EMNQKYKELKKREEHMDTFIETFEETKN-----QEL 383
+ L+ +L++ Q E++Q+ ELK++ + + + ++ T N +EL
Sbjct: 1818 NLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEEL 1877
Query: 384 KRKA-----QIEANIVALLEHCSRNINRIEQI-----SSITNQELKMMQDDLNFKSTEV- 432
+RK Q+E + + + N E++ +++ +++ L K EV
Sbjct: 1878 QRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVF 1937
Query: 433 --QKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQ----HSLKS-----KIKQMTTDL 481
K +T ++L + + +L LQ+ +L + MT +Q +L+S ++K+ DL
Sbjct: 1938 TLTKQLNTLKDLFAKADKEKLTLQR-KLKTTGMTVDQVLGIRALESEKELEELKKRNLDL 1996
Query: 482 EIYNDLPALKS----SGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEAL-------- 529
E ND+ +++ + ++ LH + L +A +K K ++
Sbjct: 1997 E--NDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDH 2054
Query: 530 ---KTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEY 586
+ +LQ+ N+E K+Q LEQ N K+ K+Q D + + + + K+ AE
Sbjct: 2055 CQREQELQKENLKLSSENIELKFQ-LEQAN---KDLPRLKNQVRDLKEMCEFLKKEKAEV 2110
Query: 587 NKTI 590
+ +
Sbjct: 2111 QRKL 2114
Score = 48.9 bits (115), Expect = 1e-05
Identities = 105/488 (21%), Positives = 209/488 (42%), Gaps = 85/488 (17%)
Query: 119 IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADY----NMLVDKLN----TNTEMEEVM 170
+E+ N +N + + ++ E L EI +L+ +++D+ L +++ T ++ E
Sbjct: 463 VEIKNCKNQIKIR-DREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFR 521
Query: 171 NDYNMLKAQNDRETQSL----DVIFTERQAKEKQIRSVEEEIEQEKQATD-------DII 219
N ++ + Q E Q L + + ER +K+IR + +E ++ AT ++
Sbjct: 522 NSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQE-RGKRSATSGLTTEDLNLT 580
Query: 220 KNMS-----FENQVKYLEMK------TTNEKLLQELDTLQQQLDS--------QNMKKES 260
+N+S E ++ L +K + NE L +EL ++ L+ QN KE
Sbjct: 581 ENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKEL 640
Query: 261 LEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQE-- 318
+E + Q+++ + + + E++ D E I + E+L+ I+ N E
Sbjct: 641 VEE---NKQLEEGMKEILQAIKEMQKDPDVKGGETSLI---IPSLERLVNAIESKNAEGI 694
Query: 319 ------IASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFI 372
+ + QLT E++ Q + E R+ ++ + + N K L+K +T +
Sbjct: 695 FDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEK-----ETSL 749
Query: 373 ETFEETKNQELKRK------AQIEANIVALLEHCSRNINRIEQISSITNQELKMMQ---- 422
E N K A A+I+ S+N I + + N+E K+
Sbjct: 750 LRQSEGSNVVFKGIDLPDGIAPSSASIIN-----SQNEYLIHLLQELENKEKKLKNLEDS 804
Query: 423 -DDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESK-MTEEQHSLKSKIKQMTTD 480
+D N K ++ QS + + L ++ ESK + EE+ L+ +++Q
Sbjct: 805 LEDYNRKFAVIRHQQSL-------LYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIK 857
Query: 481 LEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQL-QENETH 539
++ YN+L +++KK+ E T +K + +Q L+ QL +ENE
Sbjct: 858 VKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQ 917
Query: 540 -SQLTNLE 546
++L ++E
Sbjct: 918 KNELLSME 925
Score = 45.8 bits (107), Expect = 1e-04
Identities = 89/448 (19%), Positives = 184/448 (41%), Gaps = 53/448 (11%)
Query: 142 EIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQI 201
E+ E +L DY V L + E+ N N +K + DRE ++++ E E +I
Sbjct: 440 ELVEALKRLKDYESGVYGLED--AVVEIKNCKNQIKIR-DRE---IEILTKEINKLELKI 493
Query: 202 RSVEEEIEQEKQATDDIIKNM----SFENQ--VKYLEMKTTNEKLLQELDTLQQQLDSQN 255
+E E ++ K M F N +K + + N+ LL+E+++L+++
Sbjct: 494 SDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLK 553
Query: 256 MKKESLEAE----IAHSQVKQEAVLLHEKLYELE--SHRDQMIAEDKSIGSPMEEREKLL 309
K + E A S + E + L E + + + S R + K++ + E L
Sbjct: 554 KKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLS 613
Query: 310 KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMD 369
+++ + +++ + + K+ + +EE +QL+ ++E + + K+ +
Sbjct: 614 RELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETS 673
Query: 370 TFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKS 429
I + E N + A+ I H ++++ + N+EL+
Sbjct: 674 LIIPSLERLVNAIESKNAE---GIFDASLHLKAQVDQL----TGRNEELRQ--------- 717
Query: 430 TEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDL-------- 481
E+++S+ A N + + + L K++ LE + + + S S + DL
Sbjct: 718 -ELRESRKEAINYSQQLAKANL---KIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSS 773
Query: 482 -EIYND----LPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQEN 536
I N L L E K KKL L + F I +Q++ Y+ ++ +
Sbjct: 774 ASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETW 833
Query: 537 ETHSQLTNLERK--WQHLEQNNFAMKEF 562
+T S+ E++ ++Q+ +KE+
Sbjct: 834 KTESKTIKEEKRKLEDQVQQDAIKVKEY 861
Score = 45.4 bits (106), Expect = 1e-04
Identities = 100/538 (18%), Positives = 226/538 (42%), Gaps = 94/538 (17%)
Query: 126 NSVYLSYEKRAETLAVEIKEL-QGQLADY-NMLVDKLNTNTEMEEVMNDYNMLKAQNDRE 183
NS +S K+ L E+KEL + Q A++ + + L T+ + E N + + +
Sbjct: 1049 NSDIVSISKKITML--EMKELNERQRAEHCQKMYEHLRTSLKQMEERN-FELETKFAELT 1105
Query: 184 TQSLDVIFTERQAKEKQIRSVEEEI-EQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ 242
+LD E+ +++ SV + + + ++Q ++ KN E +V+ +++ ++ +
Sbjct: 1106 KINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKN-EMELKVEVSKLREISDIARR 1164
Query: 243 ELDTLQQQLDSQNMKKESLEAEI----AHSQVKQEAVLLHE--------------KLYEL 284
+++ L Q S++ + ESL ++ A S K LH+ KL +
Sbjct: 1165 QVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESI 1224
Query: 285 ESHRDQMIAEDKSIGSPMEEREKLL--------KQIKDDNQEIASMERQLTDT-----KE 331
S +M A + + ++E+E+ L + K Q I S+ RQ + +E
Sbjct: 1225 TSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQE 1284
Query: 332 KI--------NQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETK---- 379
K N ++ ++++ +EH+ M K E++ + + ++ I T ++TK
Sbjct: 1285 KFSKTMIQLQNDKLKIMQEMKNSQQEHR-NMENKTLEMELKLKGLEELISTLKDTKGAQK 1343
Query: 380 ----NQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKS 435
+ +++ E + L I + I S + + +++++ ++ ++
Sbjct: 1344 VINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEER 1403
Query: 436 QSTAQNLTSDIQRLQLDL---QKMELLESKMTEEQ-------------HSLKSKIKQMTT 479
Q D++R QLD+ Q+ E+L + E+ + L+ ++++
Sbjct: 1404 QMAWDQREVDLER-QLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKE 1462
Query: 480 DLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNI------EYEALKTQL 533
++ I + A S EEK+K+ + + + K++ + + E E L +L
Sbjct: 1463 NIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAEL 1522
Query: 534 QENE-----------THSQLTNLERKWQHLEQNNFAMKEF--IATKSQESDYQPIKKN 578
E H + N++ + L Q +K++ + K++E + +KK+
Sbjct: 1523 GRKEMEPKSHHTLKIAHQTIANMQAR---LNQKEEVLKKYQRLLEKAREEQREIVKKH 1577
Score = 35.8 bits (81), Expect = 0.12
Identities = 44/195 (22%), Positives = 89/195 (45%), Gaps = 12/195 (6%)
Query: 81 KTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLA 140
+T K + I K+ + L+ + E T K+ K E Q+ + + AET
Sbjct: 2276 ETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQ 2335
Query: 141 VEIKELQG-QLADYNM------LVDKLNTNTEM---EEVMNDYNMLKAQ-NDRETQSLDV 189
+ELQ +LA++ + L+ ++ N + E + D + LK + D ETQ L +
Sbjct: 2336 GLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQ-LKM 2394
Query: 190 IFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQ 249
E+Q +++I+ +++E+E + + I+++ + + + + EK+ + + L
Sbjct: 2395 SDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGV 2454
Query: 250 QLDSQNMKKESLEAE 264
+L S E E E
Sbjct: 2455 ELTSPVAASEEFEDE 2469
>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
Length = 1113
Score = 81.6 bits (200), Expect = 2e-15
Identities = 103/513 (20%), Positives = 207/513 (40%), Gaps = 58/513 (11%)
Query: 105 ISELTTEVNKL-QKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
ISE E+ L +K +Q NS+ E E + QL+D V +L +
Sbjct: 273 ISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRS- 331
Query: 164 TEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNM- 222
E+ E Y + +T+ L+ ++ + R+ ++ QE DD ++ +
Sbjct: 332 -ELREAKRMY-------EDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLL 383
Query: 223 -SFENQVKYLEMKTTNEKLLQELDT--------LQQQLDSQNMKKESLEAEIAHSQVKQE 273
+ K L ++ K L + DT L+++LD++NM+ + LEA
Sbjct: 384 ADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEA---------- 433
Query: 274 AVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKI 333
LL E + ++ +A + +E+ L Q++ + + + +LT K +
Sbjct: 434 --LLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTL 491
Query: 334 NQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQ-ELKRKAQIEAN 392
I L L+E + + E+ K +D ++ + KN+ + R Q E
Sbjct: 492 ESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECE 551
Query: 393 IVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLD 452
+ L + +++ I Q+++ M + Q L +I +++
Sbjct: 552 ALKL------QMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRME 605
Query: 453 LQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEK---IKKLHQERMILS 509
L+++++L+ K + L++++ +DLE+ + L ++G E+ +K + QER L
Sbjct: 606 LKELKILKDKKDAKIRELEARV----SDLEL--EKVKLVNAGSERLRAVKDIKQERDQLL 659
Query: 510 THRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQ------HLEQNNFAMKEFI 563
+ + + EYE LK + ++T + K Q LEQ +K
Sbjct: 660 NEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLK--- 716
Query: 564 ATKSQESDYQPIKKNVTKQIAEYNKTIVDALHS 596
+ + + + + KQI + +DAL S
Sbjct: 717 SMEGSDGHAMKVAMGMQKQITA-KRGQIDALQS 748
Score = 60.1 bits (144), Expect = 6e-09
Identities = 87/478 (18%), Positives = 201/478 (42%), Gaps = 54/478 (11%)
Query: 99 GLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVD 158
G L ++ +L +++K +K + + ++N R ++ I L+ +L + NM V
Sbjct: 373 GNLDDQLQKLLADLHKREKELSLEKEQNKRLWD---RDTGNSITIDHLRRELDNRNMEVQ 429
Query: 159 KLNT-----NTEMEEVMNDYNMLKAQNDRET-QSLDVIFTERQAKEKQIRSVEEEIEQEK 212
+L +E + M + M Q E+ + + + + ++ ++ +R V EE+ +K
Sbjct: 430 RLEALLKALKSECQGQM-ERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKK 488
Query: 213 ---QATDDIIKNMSFENQVKYLEMKTTNEKL----------LQELDTLQQQLDSQNMKKE 259
++++ I +++ Q K ++ TN ++ LQEL L+ + D +++
Sbjct: 489 MTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGD--HLRNV 546
Query: 260 SLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEI 319
E E Q+ ++ ++ ++E+ + ++ G+ E+ +L K+I D E+
Sbjct: 547 QTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMEL 606
Query: 320 ASMERQLTDTKE-KINQFIEEIRQLDMD--------------LEEHQGEMNQKYKELKKR 364
+ + L D K+ KI + + L+++ +++ + E +Q E+K
Sbjct: 607 KEL-KILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTS 665
Query: 365 EEHMDTFIETFEETKNQELKRKAQIEANIVAL----------LEHCSRNINRIEQISSIT 414
++ E +E K + ++E L LE + +E
Sbjct: 666 RSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHA 725
Query: 415 NQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKI 474
+ MQ + K ++ QS Q L + + ++ +SK+++E ++ ++
Sbjct: 726 MKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEK 785
Query: 475 KQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQ 532
+M +LE+ L + + +EK+ + S + I+++Q E LK Q
Sbjct: 786 NKMAGELEV---LRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQ 840
Score = 43.9 bits (102), Expect = 4e-04
Identities = 63/303 (20%), Positives = 132/303 (43%), Gaps = 31/303 (10%)
Query: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQK--- 357
P +E + +++ + ++ ++R+L ++ E + +RQ +DL+ EM +
Sbjct: 69 PSPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDA 128
Query: 358 YKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQE 417
++++RE ++ E+ +NQ ++EA + + +IEQ+ +
Sbjct: 129 MADIRRRES------QSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSH 182
Query: 418 LKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQM 477
++Q+ +S V +++ + + L + + SK+ E + S +K
Sbjct: 183 EGVLQE---IRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGR 239
Query: 478 TTDLEIYNDLPALKSSGEEKIKKL---HQERM--ILSTHRNAFKKIMEKQNIEYEALKTQ 532
+E + L ALKS + KI+ L HQ+R+ ++S H + EK A +
Sbjct: 240 IFPVE--DQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEK------ASSAR 291
Query: 533 LQENETHSQLTNLERKWQHLEQNNFAMKEFI---ATKSQ-ESDYQPIKKNVTKQIAEYNK 588
Q N SQ+ ++ Q QN+ M++ +T SQ S+ + K+ + E K
Sbjct: 292 SQANSIQSQMEIIQE--QARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEK 349
Query: 589 TIV 591
+V
Sbjct: 350 QLV 352
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.326
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,620,007
Number of Sequences: 37866
Number of extensions: 906950
Number of successful extensions: 13122
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 317
Number of HSP's successfully gapped in prelim test: 1230
Number of HSP's that attempted gapping in prelim test: 5368
Number of HSP's gapped (non-prelim): 4352
length of query: 600
length of database: 18,247,518
effective HSP length: 108
effective length of query: 492
effective length of database: 14,157,990
effective search space: 6965731080
effective search space used: 6965731080
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.