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Search of human proteins with 110347443
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110347443 TATA element modulatory factor 1 [Homo sapiens]
(1093 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110347443 TATA element modulatory factor 1 [Homo sapiens] 2085 0.0
gi|55770834 centromere protein F [Homo sapiens] 129 2e-29
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 124 6e-28
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 124 6e-28
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 124 6e-28
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 124 6e-28
gi|42794779 myosin 18A isoform b [Homo sapiens] 118 3e-26
gi|28416946 myosin 18A isoform a [Homo sapiens] 118 3e-26
gi|31982906 cingulin-like 1 [Homo sapiens] 117 5e-26
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 115 2e-25
gi|118498368 kinectin 1 isoform c [Homo sapiens] 114 4e-25
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 114 4e-25
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 114 7e-25
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 111 3e-24
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 111 3e-24
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 110 7e-24
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 110 7e-24
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 109 2e-23
gi|38044112 restin isoform b [Homo sapiens] 108 3e-23
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 108 4e-23
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 108 4e-23
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 105 2e-22
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 105 2e-22
gi|4506751 restin isoform a [Homo sapiens] 105 3e-22
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 105 3e-22
gi|71061468 centromere protein E [Homo sapiens] 105 3e-22
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 104 4e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 104 5e-22
gi|118498356 kinectin 1 isoform a [Homo sapiens] 103 7e-22
gi|33620775 kinectin 1 isoform a [Homo sapiens] 103 7e-22
>gi|110347443 TATA element modulatory factor 1 [Homo sapiens]
Length = 1093
Score = 2085 bits (5401), Expect = 0.0
Identities = 1093/1093 (100%), Positives = 1093/1093 (100%)
Query: 1 MSWFNASQLSSFAKQALSQAQKSIDRVLDIQEEEPSIWAETIPYGEPGISSPVSGGWDTS 60
MSWFNASQLSSFAKQALSQAQKSIDRVLDIQEEEPSIWAETIPYGEPGISSPVSGGWDTS
Sbjct: 1 MSWFNASQLSSFAKQALSQAQKSIDRVLDIQEEEPSIWAETIPYGEPGISSPVSGGWDTS 60
Query: 61 TWGLKSNTEPQSPPIASPKAITKPVRRTVVDESENFFSAFLSPTDVQTIQKSPVVSKPPA 120
TWGLKSNTEPQSPPIASPKAITKPVRRTVVDESENFFSAFLSPTDVQTIQKSPVVSKPPA
Sbjct: 61 TWGLKSNTEPQSPPIASPKAITKPVRRTVVDESENFFSAFLSPTDVQTIQKSPVVSKPPA 120
Query: 121 KSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEET 180
KSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEET
Sbjct: 121 KSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEET 180
Query: 181 VNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSN 240
VNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSN
Sbjct: 181 VNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSN 240
Query: 241 TPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASA 300
TPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASA
Sbjct: 241 TPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASA 300
Query: 301 CPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIV 360
CPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIV
Sbjct: 301 CPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIV 360
Query: 361 NSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEG 420
NSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEG
Sbjct: 361 NSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEG 420
Query: 421 QTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFD 480
QTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFD
Sbjct: 421 QTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFD 480
Query: 481 NLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLN 540
NLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLN
Sbjct: 481 NLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLN 540
Query: 541 SSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKEL 600
SSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKEL
Sbjct: 541 SSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKEL 600
Query: 601 EEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAAL 660
EEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAAL
Sbjct: 601 EEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAAL 660
Query: 661 DSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGD 720
DSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGD
Sbjct: 661 DSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGD 720
Query: 721 LRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQA 780
LRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQA
Sbjct: 721 LRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQA 780
Query: 781 TLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQ 840
TLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQ
Sbjct: 781 TLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQ 840
Query: 841 ENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERM 900
ENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERM
Sbjct: 841 ENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERM 900
Query: 901 KVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHS 960
KVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHS
Sbjct: 901 KVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHS 960
Query: 961 FGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEE 1020
FGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEE
Sbjct: 961 FGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEE 1020
Query: 1021 LVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMY 1080
LVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMY
Sbjct: 1021 LVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMY 1080
Query: 1081 KTQIDELLRQSLS 1093
KTQIDELLRQSLS
Sbjct: 1081 KTQIDELLRQSLS 1093
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 129 bits (323), Expect = 2e-29
Identities = 169/716 (23%), Positives = 311/716 (43%), Gaps = 111/716 (15%)
Query: 428 AEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMF 487
AE E E S+ ++ K L EKL+ E +LS K LE L E
Sbjct: 2007 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 488 RVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSS-ETAD 546
+ +ES S+ + R++E++ + K +AA E K E A RL+S+ E
Sbjct: 2067 LLVKESESLQA-------RLSESDYEKLNVSKALEAALVE----KGEFALRLSSTQEEVH 2115
Query: 547 LLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQH 606
L+ E++R +E E K+QLH I +KL+ +++EN++ L KV+ LE ELQ
Sbjct: 2116 QLRRGIEKLRVRIEADE---KKQLH---IAEKLKERERENDS----LKDKVENLERELQM 2165
Query: 607 LKQ-----VLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALD 661
++ +LD + + ++ L + +E + L ++D+ L + ++ +
Sbjct: 2166 SEENQELVILDAENS-----KAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
Query: 662 SAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDL 721
+L++L K ++ S +E E++ KEE A+E Q + ++ E +A GD
Sbjct: 2221 EKQGQLSELDKLLSSFKSLLEEKE-QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQ 2279
Query: 722 RLALQRTEQA---AARKEDYLRHEIGELQQRLQEAENRN----QELSQSVSSTTRPLLRQ 774
+ ++ TEQ+ +E LR+ I +L+ RL+ E + Q+L +S L +
Sbjct: 2280 EI-MKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADL-LKGR 2337
Query: 775 IENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQ 834
+ENL+ L ++ E + GE +TL A + T+ L ++ + ++ S+
Sbjct: 2338 VENLERELEIARTNQEHAALEAENSKGEVETLKA----KIEGMTQSLRGLELDVVTIRSE 2393
Query: 835 NSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQ 894
L E L+ E+ R+ +LE N+ ++ L+ + E V+ E++ +L +Q
Sbjct: 2394 KENLTNE-------LQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446
Query: 895 LEMERMKVEQERKKAIFT-QETIKEKERKPFSVSSTPTMSRSSSISGVDMAG-----LQT 948
L K ER A+ QE K KE+ S + ++ + G+D A LQ+
Sbjct: 2447 L-----KELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQS 2501
Query: 949 SF-------------------------------------LSQDESHDHSFGPMPISANGS 971
S LSQ E + +
Sbjct: 2502 SVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNL 2561
Query: 972 NLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDEL 1031
+ ++ S +LQ L++ + +L+ E+ + + E++ K+T + EL
Sbjct: 2562 TVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETEL 2621
Query: 1032 EEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDEL 1087
+ ++ E+ + +L++ ++ GEK A EL+L LE++K+ K Q+ EL
Sbjct: 2622 QREMHEMAQKTAELQE---------ELSGEKNRLAGELQLLLEEIKSS-KDQLKEL 2667
Score = 114 bits (286), Expect = 4e-25
Identities = 182/823 (22%), Positives = 373/823 (45%), Gaps = 94/823 (11%)
Query: 346 DELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNC 405
D +S K AL + S K KT E +SE ++ I EAE++E ++
Sbjct: 1968 DTMSKKTTALDQL---SEKMKEKTQELESHQSECLH---CIQVAEAEVKEKTELLQTLSS 2021
Query: 406 EQPDILVSSTPINEGQTVLDKVAE-----QCEPAESQPEALSEKEDVCKTVEFLNEKLEK 460
+ ++L T + E L+K ++ +CE + EKE + K E L +L +
Sbjct: 2022 DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081
Query: 461 REAQLLSLSK--EKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLAC 518
+ + L++SK E AL+E+ L+ + +EE + ++ RI EA++K QL
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALR--LSSTQEEVHQLRRGIEKLRVRI-EADEKKQLHI 2138
Query: 519 --------KERDAAKKEIKNIKEELATRLNSSETADLLKEKDE-QIRGLMEEGEKLSKQQ 569
+E D+ K +++N++ EL + E L E + ++ L + E++++
Sbjct: 2139 AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSL 2198
Query: 570 LHNSNIIKKLRAKDKENENMVAKLNKK---VKELEEELQHLKQVLDGKEEVEKQHRENIK 626
+ LR+ E EN+ ++ +K + EL++ L K +L+ KE+ E Q +E K
Sbjct: 2199 KVFELDLVTLRS---EKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK 2255
Query: 627 KLNSMVERQEKDLGR----LQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDS-EA 681
M++ Q K+L L D + ++ +S+ ++ ++ + K A ++ E
Sbjct: 2256 TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK 2315
Query: 682 QEAALSREMKAKEELSAAL-------EKAQEEARQQQETLAIQ-------VGDLRLALQR 727
++ + +++K E + L E+ E AR QE A++ V L+ ++
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEG 2375
Query: 728 TEQAAARKE---DYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGS 784
Q+ E +R E L LQ+ + R EL + ++S+ +L++ E + +
Sbjct: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISEL-EIINSSFENILQEKEQEKVQMKE 2434
Query: 785 QTSS-WEKLE---KNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSM-----ESQN 835
++S+ E L+ K L++R+ A +E+ + ++ +++ + + E++N
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKN 2494
Query: 836 S--LLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNS 893
+ +L+ + ++E K +L K ++E +R + ++++ +++ V L + E L
Sbjct: 2495 NYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD-QEQLVSKLSQVEGEHQLWKE 2553
Query: 894 Q-LEMERMKVEQERK------KAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGL 946
Q LE+ + VE E+K K Q+T++ + ++ + +++ +S V+
Sbjct: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
Query: 947 QTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLE 1006
T+ ++ + H + R+ AG ++ L ++K + ++ L LE
Sbjct: 2614 MTAKETELQREMHEMAQKTAELQEELSGEKNRL-AGE--LQLLLEEIKSSKDQLKELTLE 2670
Query: 1007 IGNLEKTRSIMAEELV----KLTNQNDELEEKVKEIPKL-RTQLRDLDQRYNTILQMYGE 1061
L+K+ M ++ V K+ + E + ++ E K + L D +++Y +Q Y E
Sbjct: 2671 NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730
Query: 1062 KAEEAEE------LRLDL-----EDVKNMYK--TQIDELLRQS 1091
K EE L +DL E++ N K TQI E L+++
Sbjct: 2731 KLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKT 2773
Score = 109 bits (272), Expect = 2e-23
Identities = 183/933 (19%), Positives = 394/933 (42%), Gaps = 108/933 (11%)
Query: 183 KESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSNTP 242
KE + T+S VSE + D E + QSL +++ ++L E +++ Q N
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKL-----QSLEKDSQALSLTKCELENQIAQLNKE 2064
Query: 243 SPPVSTFSSGTS---TTSDIEVLDHESVISESSASSRQ---ETTDSKSSLHLMQTSFQLL 296
+ S + SD E L+ + + + + ++ +H ++ + L
Sbjct: 2065 KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKL 2124
Query: 297 SASA-CPEYNRLDDFQKLTESCCSSDAF----ERIDSFSVQSLDSRSVSEINSDDELSGK 351
E +L +KL E +D+ E ++ S +++ + +++++ +
Sbjct: 2125 RVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2184
Query: 352 GYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNC-----E 406
I + + K ++ +SE+ N T I ++ ++ E + + E
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 407 QPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVE-FLNEKLEKREAQL 465
Q +I + E +T ++ + Q + AL +++ K E L+ +E+
Sbjct: 2245 QAEIQIKE----ESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLR 2300
Query: 466 LSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAK 525
S+ K +A LE + ++KE LK R+ E+++++A ++ A
Sbjct: 2301 NSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKG----RVENLERELEIARTNQEHAA 2356
Query: 526 KEIKNIKEELAT------------RLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNS 573
E +N K E+ T R + + EK+ L +E E++S+ ++ NS
Sbjct: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416
Query: 574 NIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVE 633
+ L+ K++E M K + ++ L+ +L+ L + + ++ + + L+S VE
Sbjct: 2417 SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2476
Query: 634 RQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAK 693
E + +L +DE + +Q++++ +E+ D + KD E + L +++ +
Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEI--SRLKNQIQDQ 2534
Query: 694 EELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEA 753
E+L + L + + E + +E +++ +L + L++ Q K L+ + LQ +
Sbjct: 2535 EQLVSKLSQVEGEHQLWKEQ-NLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL 2593
Query: 754 ENR----NQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLS---DRL-GESQT 805
EN + V + ++ E LQ + +L++ LS +RL GE Q
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETE-LQREMHEMAQKTAELQEELSGEKNRLAGELQL 2652
Query: 806 LLAAAVERERAATEELLANKIQMSSME-------SQNSLLRQENSRFQAQL-ESEKNRLC 857
LL + E L N S++ + +R+E + +Q +L E+EK
Sbjct: 2653 LLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQA 2712
Query: 858 KLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIK 917
L D N +Y+VE++ +++ T KE+ L + +LE++ +K
Sbjct: 2713 LLLDTNKQYEVEIQTYREKL------TSKEECLSSQKLEIDLLK---------------S 2751
Query: 918 EKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQ-DESHDHSFGPMPISANGSNLYDA 976
KE S+ +T + + +D +++Q + ++ + G M +
Sbjct: 2752 SKEELNNSLKATTQILEELKKTKMD----NLKYVNQLKKENERAQGKMKLLIKS------ 2801
Query: 977 VRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVK 1036
+ L+ + ++ + E++ LQ +KT ++M ++ +LT + EL+E ++
Sbjct: 2802 ---------CKQLEEEKEILQKELSQLQ-AAQEKQKTGTVMDTKVDELTTEIKELKETLE 2851
Query: 1037 EIPKLRTQLRDLDQRYNTILQMYGEKAEEAEEL 1069
E K + D +Y ++L + EK E+A+E+
Sbjct: 2852 EKTKEADEYLD---KYCSLLISH-EKLEKAKEM 2880
Score = 109 bits (272), Expect = 2e-23
Identities = 185/877 (21%), Positives = 361/877 (41%), Gaps = 114/877 (12%)
Query: 123 QRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEETVN 182
Q +V L + H+ + +SQ + C +A + K E++
Sbjct: 2017 QTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ 2076
Query: 183 ---KESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQS 239
ESD + VS + ++++ +S+T + L + + E +Q
Sbjct: 2077 ARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQL 2136
Query: 240 NTPSPPVSTFSSGTSTTSDIEVLDHESVISESSA--------SSRQETTDSKSSLHLMQT 291
+ S +E L+ E +SE + +S+ E K+ + M
Sbjct: 2137 HIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMAR 2196
Query: 292 SFQLLSASACPEYNRLDDFQK-LTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSG 350
S ++ + ++ K + E +++ S L+ + +EI +E
Sbjct: 2197 SLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK- 2255
Query: 351 KGYALVPIIVNSSTPKSKTVESAEGKSEEVNET---LVIPTEEAEMEESG--RSATPVNC 405
V ++ N ++ V + G E + T L P EE + + +
Sbjct: 2256 ---TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312
Query: 406 EQPDILVSSTPINEGQTVLDKVAEQCEPAE--------SQPEALSEKEDVCKTVEFLNEK 457
++ L + E + D + + E E +Q A E E+ VE L K
Sbjct: 2313 DEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAK 2372
Query: 458 LEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEK-KVQL 516
+E L L + + +NL +E+ + +E S + + F + E E+ KVQ+
Sbjct: 2373 IEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQM 2432
Query: 517 ACKERDAAKK---EIKNIKEELATRLN------------SSETADLLKEKDEQIRGLMEE 561
K A + ++K + E +A N SS+ L EK + ++GL E
Sbjct: 2433 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
Query: 562 GEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQH 621
Q + +I+++ ++ + + K ++++ L+ ++Q +Q++ +VE +H
Sbjct: 2493 KNNYIVLQSSVNGLIQEV----EDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEH 2548
Query: 622 R----ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALD---SAYK------ELT 668
+ +N++ N VE ++K +QV L+ KN S+Q L+ S+YK ELT
Sbjct: 2549 QLWKEQNLELRNLTVELEQK----IQV----LQSKNASLQDTLEVLQSSYKNLENELELT 2600
Query: 669 DLHKAN--------AAKDSEAQE---------AALSREMKA-KEELSAALEKAQEE---A 707
+ K + AK++E Q A L E+ K L+ L+ EE +
Sbjct: 2601 KMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS 2660
Query: 708 RQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSST 767
+ Q + L ++ +L+ +L + KE +R EI E Q RL EAE ++Q L + T
Sbjct: 2661 KDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL---LLDT 2717
Query: 768 TRPLLRQIENLQATLGSQTS--SWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANK 825
+ +I+ + L S+ S +KLE +L L S+ L +++ EEL K
Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQKLEIDL---LKSSKEELNNSLKATTQILEEL--KK 2772
Query: 826 IQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETR 885
+M +++ N L ++EN R Q +++ +LE+E Q EL L + +E +
Sbjct: 2773 TKMDNLKYVNQL-KKENERAQGKMKLLIKSCKQLEEEKEILQKELSQL-----QAAQEKQ 2826
Query: 886 KEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERK 922
K T+++++++ ++++ +ET++EK ++
Sbjct: 2827 KTGTVMDTKVDELTTEIKE-------LKETLEEKTKE 2856
Score = 89.4 bits (220), Expect = 2e-17
Identities = 196/969 (20%), Positives = 391/969 (40%), Gaps = 140/969 (14%)
Query: 178 EETVNKESDMKVPTVSL--KVSESVIDVKTTMESIS-NTSTQSLTAETKDIALEPKEQKH 234
E+ +NK D V T + + S ++ ++ ++ + S Q AE+ +LE K ++
Sbjct: 333 EKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEK 392
Query: 235 EDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQ 294
E S +F + LD E + + A QE +K+ +++Q
Sbjct: 393 EKEFQEELSRQQRSF----------QTLDQECI--QMKARLTQELQQAKNMHNVLQAELD 440
Query: 295 LLSASACPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYA 354
L++ N L++F++ + C + AF+ S ++ RS+ E+ ++ L
Sbjct: 441 KLTSVKQQLENNLEEFKQ--KLCRAEQAFQA--SQIKENELRRSMEEMKKENNL------ 490
Query: 355 LVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSS 414
+ + S K++ V E + + + + L AE ++ ++ ++
Sbjct: 491 ----LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ 546
Query: 415 TPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKT----VEFLNEKLEKREAQLLSLSK 470
E L+K+ E Q + +D+ K +E LN+KL K E K
Sbjct: 547 ---QENSLTLEKLKLAVADLEKQRDC---SQDLLKKREHHIEQLNDKLSKTE-------K 593
Query: 471 EKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKN 530
E L A + K E +KEE + S K E + + + E +
Sbjct: 594 ESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESE----------------- 636
Query: 531 IKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMV 590
KE L +++N ET K +QI+ E E++ ++ N+ ++R N+
Sbjct: 637 -KENLQSKINHLETC----LKTQQIKS-HEYNERVRTLEMDRENLSVEIR-------NLH 683
Query: 591 AKLNKKVKELEEE---LQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDL-GRLQVDM 646
L+ K E+E + L+Q + ++ ++ EN+ S + Q +DL +LQ+
Sbjct: 684 NVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLS 743
Query: 647 DELEEKNRSIQAALDSAYKELTDLHK---ANAAKDSEAQEAALSREMKAK---------- 693
+E+ +K+R Q L + Y+ L DL K A+ + + Q + L+ + +
Sbjct: 744 NEIMDKDRCYQ-DLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIG 802
Query: 694 EELSAALEKAQ--EEARQQQETLAI---QVGDLRLALQRTEQAAARKEDYLRHEI---GE 745
E+ S E+++ EA Q + AI +V L +L+ +Q + + + GE
Sbjct: 803 EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGE 862
Query: 746 LQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLS-------- 797
+++ L +AE +Q S L Q + S+ E EK L
Sbjct: 863 IEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVET 922
Query: 798 -----DRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESE 852
L +S LL +++ + +E L K +MSS+ S N R +L E
Sbjct: 923 EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISL-------NKREIEELTQE 975
Query: 853 KNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFT 912
L ++ N+ ++ L + + ++E K + L+ Q + E++ + Q ++
Sbjct: 976 NGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNA 1035
Query: 913 QETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPIS---AN 969
E + +K + +S + S + + L + + +H ++
Sbjct: 1036 YEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER 1095
Query: 970 GSNL---YDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTN 1026
NL + V+ S + +N + + E L+ EI L++ ++ M +E+ L
Sbjct: 1096 NQNLMLELETVQQALRSEMTDNQNNS----KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQ 1151
Query: 1027 QNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLE------DVKNMY 1080
+N++L + +K K Q + + N++ + E+ + + ++DLE D N
Sbjct: 1152 ENEQLMKVMK--TKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQ 1209
Query: 1081 KTQIDELLR 1089
Q++ +LR
Sbjct: 1210 LVQLEAMLR 1218
Score = 89.0 bits (219), Expect = 2e-17
Identities = 137/659 (20%), Positives = 277/659 (42%), Gaps = 89/659 (13%)
Query: 449 KTVEFLNEKLE------KREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSIS--SLK 500
+T E LN LE RE +++K +E F ++++E+ R++ E +SI +L
Sbjct: 1861 ETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALY 1920
Query: 501 DEFTQRIAEAEKKVQLACKERDAAKKE--IKNIKEELATRLNSSETADLLKEKDEQIRGL 558
E + + EK C E+D K+ I ++EEL+ ++ + Q+RG
Sbjct: 1921 LEADLEVVQTEK----LCLEKDNENKQKVIVCLEEELS----------VVTSERNQLRG- 1965
Query: 559 MEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVE 618
E + +SK+ + +K++ K +E E+ + E H QV + +
Sbjct: 1966 --ELDTMSKKTTALDQLSEKMKEKTQELESH-----------QSECLHCIQVAEAE---V 2009
Query: 619 KQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKAN--AA 676
K+ E ++ L+S V KD LQ + LE+ ++++ ++ L+K
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLV 2069
Query: 677 KDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKE 736
K+SE+ +A LS K +S ALE A ++ G+ L L T++ +
Sbjct: 2070 KESESLQARLSESDYEKLNVSKALEAA-----------LVEKGEFALRLSSTQEEVHQ-- 2116
Query: 737 DYLRHEIGELQQRLQEAENRNQELSQSVSSTTR---PLLRQIENLQATLGSQTSSWEKLE 793
LR I +L+ R++ E + +++ + R L ++ENL+ L + E +
Sbjct: 2117 --LRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVI 2174
Query: 794 KNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEK 853
+ + E +TL E R+ + E LR E Q++ ++
Sbjct: 2175 LDAENSKAEVETLKTQIEEMARS-----------LKVFELDLVTLRSEKENLTKQIQEKQ 2223
Query: 854 NRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKV-----EQERKK 908
+L +L+ + ++ LE + ++ EE++ +L +QL+ V +QE K
Sbjct: 2224 GQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2283
Query: 909 AIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISA 968
A +E S +R + + LQ L + E H +
Sbjct: 2284 ATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQ--LKESEHHADL-----LKG 2336
Query: 969 NGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQN 1028
NL + + + E+ + + +GE+ L+ +I + ++ + ++V + ++
Sbjct: 2337 RVENLERELEIARTNQ--EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEK 2394
Query: 1029 DELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDEL 1087
+ L ++++ + ++L ++ + ILQ EK +E +++ M +TQ+ EL
Sbjct: 2395 ENLTNELQKEQERISELEIINSSFENILQ---EKEQEKVQMKEKSSTAMEMLQTQLKEL 2450
Score = 85.5 bits (210), Expect = 3e-16
Identities = 156/719 (21%), Positives = 289/719 (40%), Gaps = 118/719 (16%)
Query: 462 EAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKER 521
+A+L L+ K LE + K ++ R E++ S +K+ +R E KK K
Sbjct: 436 QAELDKLTSVKQQLENNLEEFKQKLCRA-EQAFQASQIKENELRRSMEEMKKENNLLKSH 494
Query: 522 DAAKK--------EIKNIK----------EELATRLNSSETA--DLLKEKDEQIRGLMEE 561
K E+KNIK EE+ + S ET DL ++ ++Q L E
Sbjct: 495 SEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE 554
Query: 562 GEKLS----------------KQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQ 605
KL+ K++ H + KL +KE++ +++ L K KE EE +
Sbjct: 555 KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614
Query: 606 HLKQVLDGKEEVEK---QHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDS 662
K E EK Q + L S + E L Q+ E E+ R+++ ++
Sbjct: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDREN 674
Query: 663 AYKELTDLHKANAAKDSEAQEAALS-REMKAKEELSAALEKAQEEARQ---QQETLAIQV 718
E+ +LH +K E + L+ E++ K E S +K Q+E + L QV
Sbjct: 675 LSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD--QKHQKEIENMCLKTSQLTGQV 732
Query: 719 GDLRLALQRTEQAAARKE---DYLRHEIGELQQRLQEAE-----NRNQELSQSVSSTTRP 770
DL LQ K+ L E L+ L+ + N + + S
Sbjct: 733 EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPA 792
Query: 771 LLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEEL-LANKIQMS 829
+ N+ GS S + RL Q+ +A+ + R + E L ++ QM+
Sbjct: 793 MHHSFANIIGEQGSMPSERSEC------RLEADQSPKNSAILQNRVDSLEFSLESQKQMN 846
Query: 830 SM-------------ESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDE 876
S E + +L++ E Q+ + R+ KL+++ + +Q N+ E
Sbjct: 847 SDLQKQCEELVQIKGEIEENLMKAEQMH-QSFVAETSQRISKLQEDTSAHQ----NVVAE 901
Query: 877 YVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSS 936
+ LE KE LLN ++E E+ ++++ +K ++++KE + +S T ++ +
Sbjct: 902 TLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQ----LLSETLSLEKKE 957
Query: 937 SISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLR 996
S + + + L+Q+ G + N S + + + S E+ + + R
Sbjct: 958 MSSIISLNKREIEELTQEN------GTLK-EINASLNQEKMNLIQKS---ESFANYIDER 1007
Query: 997 EGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDL-------- 1048
E I+ L ++ + I+ + + N ++L +K K + ++L L
Sbjct: 1008 EKSISELS---DQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLC 1064
Query: 1049 DQRYNTILQMYGEKAEEAEE--------------LRLDLEDVKNMYKTQIDELLRQSLS 1093
+ R N + Q+ A+E +E L L+LE V+ ++++ + S S
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKS 1123
Score = 80.1 bits (196), Expect = 1e-14
Identities = 145/704 (20%), Positives = 294/704 (41%), Gaps = 70/704 (9%)
Query: 440 ALSEKEDVCKTVEFLNEKLEKREAQLLSLS----KEKALLEEAFD---NLKDEMFRVKEE 492
AL + +++ ++ L ++ ++R+ QL SL K+K +E NLK E R+ E
Sbjct: 16 ALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI 75
Query: 493 SSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKD 552
S+ K + + + E +V + ++ KK+I+ +++EL + E + +
Sbjct: 76 CESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSA 135
Query: 553 EQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKE---LEEELQHL-- 607
+ +K+ L S + E++ K NK+V+E LE E++ L
Sbjct: 136 DVSLNPCNTPQKIFTTPLTPSQYY-----SGSKYEDLKEKYNKEVEERKRLEAEVKALQA 190
Query: 608 KQVLDGKEEVEKQHRENIKKLNS---MVERQEKDLGRLQVDMDELEEKNRSIQAALDSAY 664
K+ + HR+ + S +QEK L + + R A+ S
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIR-RDFSASYFSGE 249
Query: 665 KELTDLHK--------ANAAKDSEAQEAALSREMKAK-EELSAALEKAQEEARQQQETLA 715
+E+T AN++ + L ++KA+ +EL + + + + ++ +
Sbjct: 250 QEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMK 309
Query: 716 IQVG---DLRLALQRTEQAAARKEDYL---RHEIGELQQRLQEAENRNQELSQSVSSTTR 769
QV +L+L L++ + KE L R E+ + +A + L Q + T
Sbjct: 310 GQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTE 369
Query: 770 PLLRQIENLQATLGSQTSSWEKLEKNLSDRLGES----QTLLAAAVERERAATEELLANK 825
L Q +N ++ S ++ EK + L QTL ++ + T+EL K
Sbjct: 370 DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAK 429
Query: 826 IQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETR 885
+ ++++ L + + LE K +LC+ E Q++ ++E R++EE +
Sbjct: 430 NMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK----ENELRRSMEEMK 485
Query: 886 KEKTLLNSQLEME-----RMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSR------ 934
KE LL S E + ++ E + K Q +E K + +S TM R
Sbjct: 486 KENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKN-TSQETMLRDLQEKI 544
Query: 935 SSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANG-SNLYDAVRMGAGSSIIENLQSQL 993
+ + + + L+ + ++ D S + + L D + S + L S L
Sbjct: 545 NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKES--KALLSAL 602
Query: 994 KLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPK-LRTQ---LRDLD 1049
+L++ E L+ E +S + L ++ ++ + L+ K+ + L+TQ + +
Sbjct: 603 ELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYN 662
Query: 1050 QRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQSLS 1093
+R T L+M + E L +++ ++ N+ ++ E+ Q L+
Sbjct: 663 ERVRT-LEM------DRENLSVEIRNLHNVLDSKSVEVETQKLA 699
Score = 80.1 bits (196), Expect = 1e-14
Identities = 173/825 (20%), Positives = 333/825 (40%), Gaps = 102/825 (12%)
Query: 121 KSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPK----TEGK 176
K + E+E K+ L +L + + E E + S E L S K ++
Sbjct: 587 KLSKTEKESKALL-SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKIN 645
Query: 177 HEETVNKESDMKVPTVSLKVSESVIDVKTTMESISNT----STQSLTAETKDIALEPKEQ 232
H ET K +K + +V +D + I N ++S+ ET+ +A +Q
Sbjct: 646 HLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQ 705
Query: 233 KHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTS 292
K E + + T +E L+H+ + + + LH S
Sbjct: 706 KAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD---LHAEYES 762
Query: 293 FQLLSASACPEYNRLDDFQK----LTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDEL 348
+ L S +D Q+ + +F I RS + +D
Sbjct: 763 LRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ-- 820
Query: 349 SGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQP 408
S K A++ V+S ++ + ++ E LV + E+EE+ A ++ Q
Sbjct: 821 SPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV--QIKGEIEENLMKAEQMH--QS 876
Query: 409 DILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSL 468
+ +S I++ Q D A Q AE+ AL KE K ++ LN+K+E +A++ L
Sbjct: 877 FVAETSQRISKLQE--DTSAHQNVVAETL-SALENKE---KELQLLNDKVETEQAEIQEL 930
Query: 469 SKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEI 528
K LLE D+LK+ ++ S ++S K E + I+ +++++ +E K+
Sbjct: 931 KKSNHLLE---DSLKE----LQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEIN 983
Query: 529 KNIKEELATRLNSSET-ADLLKEKDEQIRGLMEE--GEKLSKQQLHN------SNIIKKL 579
++ +E + SE+ A+ + E+++ I L ++ EKL Q ++ +K
Sbjct: 984 ASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKY 1043
Query: 580 RAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDL 639
+A ++N + LN+ E L+Q+ KE K+H+E + KL ER +
Sbjct: 1044 KAAQEKNSKLECLLNECTSLCENRKNELEQL---KEAFAKEHQEFLTKLAFAEERNQ--- 1097
Query: 640 GRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAA 699
L ++++ +++ RS E+TD +S+++ L +E+ +E
Sbjct: 1098 -NLMLELETVQQALRS----------EMTD-----NQNNSKSEAGGLKQEIMTLKEEQNK 1141
Query: 700 LEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKE-DYLRHEIGELQQRLQEAENRNQ 758
++K + Q+ E L + + +T+ E + +R+ + E + + + Q
Sbjct: 1142 MQKEVNDLLQENEQL--------MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQ 1193
Query: 759 ELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTL------------ 806
+ + Q+ L+A L ++ ++ EK E QT+
Sbjct: 1194 MDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDM 1253
Query: 807 ----LAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDE 862
++ + E A E+ ++ ++S+ SQN +N+ Q L++ N+L +LE
Sbjct: 1254 QSQEISGLKDCEIDAEEKYISGPHELST--SQN-----DNAHLQCSLQTTMNKLNELEKI 1306
Query: 863 NNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERK 907
Q E K E V L ++R E ++ E K+ E K
Sbjct: 1307 CEILQAE----KYELVTELNDSRSECITATRKMAEEVGKLLNEVK 1347
Score = 77.4 bits (189), Expect = 7e-14
Identities = 103/462 (22%), Positives = 210/462 (45%), Gaps = 44/462 (9%)
Query: 470 KEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDA----AK 525
K A+L+ D+L+ + K+ +S + +E Q E E+ + A + +
Sbjct: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS 882
Query: 526 KEIKNIKEELATRLNS-SETADLLKEKDEQIRGLME--EGEKLSKQQLHNSNIIKKLRAK 582
+ I ++E+ + N +ET L+ K+++++ L + E E+ Q+L SN + + K
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
Query: 583 DKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHREN--IKKLNSMVERQEKDL- 639
+ + + L KK E+ + + K E+E+ +EN +K++N+ + +++ +L
Sbjct: 943 ELQLLSETLSLEKK------EMSSIISL--NKREIEELTQENGTLKEINASLNQEKMNLI 994
Query: 640 GRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAA 699
+ + + ++E+ +SI + L YK+ + + A E LS++ KA +E ++
Sbjct: 995 QKSESFANYIDEREKSI-SELSDQYKQEKLILLQRCEETGNAYED-LSQKYKAAQEKNSK 1052
Query: 700 LEKAQEEARQQQETLAIQVGDLRLALQRTEQA-------AARKEDYLRHEIGELQQRLQE 752
LE E E ++ L+ A + Q A + L E+ +QQ L+
Sbjct: 1053 LECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRS 1112
Query: 753 AENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVE 812
NQ S+S + + + ++ Q K++K ++D L E++ L+ V
Sbjct: 1113 EMTDNQNNSKSEAGGLKQEIMTLKEEQ----------NKMQKEVNDLLQENEQLMK--VM 1160
Query: 813 RERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELEN 872
+ + + L + I+ +S++ + S Q N + Q LE ++ L D N V+LE
Sbjct: 1161 KTKHECQNLESEPIR-NSVKERESERNQCNFKPQMDLEVKEISL----DSYNAQLVQLEA 1215
Query: 873 LKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQE 914
+ L+E+ KEK L +L+ R +E + + +QE
Sbjct: 1216 MLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQE 1257
Score = 71.2 bits (173), Expect = 5e-12
Identities = 147/736 (19%), Positives = 293/736 (39%), Gaps = 100/736 (13%)
Query: 115 VSKPPAKSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTE 174
+ K +S P E + L S+ ++R + Q LCV + + + +
Sbjct: 2281 IMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ-----LCVLQQLKESEHHADLLK 2335
Query: 175 GKHEETVNKESDMKVPTVS-----LKVSESVIDVKTTMESISNTSTQSLTAETKDIALEP 229
G+ E N E ++++ + L+ S +V+T I TQSL D+
Sbjct: 2336 GRVE---NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGM-TQSLRGLELDVVTIR 2391
Query: 230 KEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDH--ESVISESSASSRQETTDSKSSLH 287
E+++ + +S ++E+++ E+++ E Q S +++
Sbjct: 2392 SEKENLTNELQKEQERIS----------ELEIINSSFENILQEKEQEKVQMKEKSSTAME 2441
Query: 288 LMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDE 347
++QT + L+ +N E+C A E+ S V+ L+ + DE
Sbjct: 2442 MLQTQLKELNERVAALHND-------QEAC---KAKEQNLSSQVECLELEKAQLLQGLDE 2491
Query: 348 LSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQ 407
Y ++ VN + VE + K E+ +E + + + +E
Sbjct: 2492 AKNN-YIVLQSSVNGLIQE---VEDGKQKLEKKDEEISRLKNQIQDQEQ----------- 2536
Query: 408 PDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLS 467
LVS EG+ L K E E ++ TVE L +K++ +++ S
Sbjct: 2537 ---LVSKLSQVEGEHQLWK------------EQNLELRNL--TVE-LEQKIQVLQSKNAS 2578
Query: 468 LSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKE 527
L +L+ ++ NL++E+ K + S ++ T + E ++++ ++ ++E
Sbjct: 2579 LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEE 2638
Query: 528 IKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENE 587
+ K LA L LL+E + ++L + L NS + K L K+
Sbjct: 2639 LSGEKNRLAGELQL-----LLEE-------IKSSKDQLKELTLENSELKKSLDCMHKDQV 2686
Query: 588 NMVAKLNKKVKEL-----EEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRL 642
K+ +++ E E E +H +LD ++ E + + +KL S +E+ L
Sbjct: 2687 EKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS----KEECLSSQ 2742
Query: 643 QVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEK 702
++++D L+ + +L + + L +L K D+ L +E + + L K
Sbjct: 2743 KLEIDLLKSSKEELNNSLKATTQILEELKKTKM--DNLKYVNQLKKENERAQGKMKLLIK 2800
Query: 703 AQEEARQQQETLAIQVGDLRLAL--QRTEQAAARKEDYLRHEIGELQQRLQEAENRNQEL 760
+ ++ +++E L ++ L+ A Q+T K D L EI EL++ L+E E
Sbjct: 2801 SCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEY 2860
Query: 761 SQSVSS---TTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLG---ESQTLLAAAVERE 814
S + L + E L+ + S K + S LG + + + E+
Sbjct: 2861 LDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKR 2920
Query: 815 RAATEELLANKIQMSS 830
++ + + K Q SS
Sbjct: 2921 LSSGQNKASGKRQRSS 2936
Score = 60.1 bits (144), Expect = 1e-08
Identities = 153/755 (20%), Positives = 299/755 (39%), Gaps = 114/755 (15%)
Query: 421 QTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFD 480
Q ++ EQ + + + L E E + K ++ +E + E++ + S ++ E
Sbjct: 1130 QEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE-CQNLESEPIRNSVKERESERNQC 1188
Query: 481 NLKDEM-FRVKEES-SSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATR 538
N K +M VKE S S ++ + + E K+Q + KE++ + E++ I+ +L
Sbjct: 1189 NFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDL--- 1245
Query: 539 LNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLN---K 595
ET++L + ++I GL + ++ + + +L +N ++ L
Sbjct: 1246 ----ETSNLQDMQSQEISGLKDCEIDAEEKYISGPH---ELSTSQNDNAHLQCSLQTTMN 1298
Query: 596 KVKELE--------EELQHLKQVLDGKEE---VEKQHRENIKKLNSMVERQEKDLGRLQV 644
K+ ELE E+ + + ++ D + E ++ E + KL + V+ D G L
Sbjct: 1299 KLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHG 1358
Query: 645 DM----------DELEEKNRSIQAALD--SAYKELTDLHKANAAKDSEAQEAALSREMKA 692
++ ++ E++ A LD ++Y+ LT K +E QE LS + +
Sbjct: 1359 ELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEH 1418
Query: 693 KEELSAALEKAQEEARQQQETLAIQVGDLRLALQ-RTEQAAARKEDYLRHEIGELQQRLQ 751
K + + + + Q +++ +L L+ R Q KE L E G +
Sbjct: 1419 KILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSS 1478
Query: 752 EAENRNQELSQ-SVSSTTRPLLRQ------IENLQATLGSQTSSWEKL------EKNLSD 798
+ LS SS R LL Q + NL+ + + S +++ E+NL+
Sbjct: 1479 SCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTR 1538
Query: 799 RLGESQTLLAAAVERERAATEELLANKIQMSS-MESQNSLLRQENSRFQAQLESEKNRLC 857
+ E+ + A VE + E + ++ MESQ + +E + L SE+ L
Sbjct: 1539 K--ETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELD 1596
Query: 858 KLE----DENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVE---------- 903
L EN ++Q +L ++ E L +K+ L+ +LE+ R++++
Sbjct: 1597 CLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLL 1656
Query: 904 --------QERKKA--IFTQETIKEKERKP--------------------FSVSSTPTMS 933
Q R ++ I + T + ER P ++ T +
Sbjct: 1657 GIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVK 1716
Query: 934 RSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQL 993
+ SG +D++ S +S +G N + I NLQ ++
Sbjct: 1717 PTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRV 1776
Query: 994 KL--------------REGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIP 1039
K R+ ++ L E+ L+ + +L+ ELE+ V E+
Sbjct: 1777 KETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELK 1836
Query: 1040 KLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLE 1074
K + L + + ++ Q ++ E +E L DLE
Sbjct: 1837 KENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLE 1871
Score = 55.8 bits (133), Expect = 2e-07
Identities = 90/420 (21%), Positives = 162/420 (38%), Gaps = 26/420 (6%)
Query: 680 EAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYL 739
E +E +R ++ +EL L+K ++E +Q+Q Q+ L ALQ+ +Q E
Sbjct: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQ----FQLDSLEAALQKQKQ-KVENEKTE 61
Query: 740 RHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDR 799
+ QRL E ++ Q +S + Q+ + L S EKLE+ L
Sbjct: 62 GTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRC 121
Query: 800 LGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKL 859
E + AA + + KI + L ++ E K + K
Sbjct: 122 KSELERSQQAAQSADVSLNPCNTPQKIFTTP-------LTPSQYYSGSKYEDLKEKYNKE 174
Query: 860 EDENNRYQVELENLKDEYV-RTL-EETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIK 917
+E R + E++ L+ + +TL + T + + Q +QE+ + + + +
Sbjct: 175 VEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQR 234
Query: 918 EKERKPFSV---SSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLY 974
R+ FS S ++ S S + +SF + S H + A L
Sbjct: 235 TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFF-DNSSSPHLLD--QLKAQNQELR 291
Query: 975 DAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEK 1034
+ + + + LQ K +G++ Q LEK + + E+ L DEL
Sbjct: 292 NKI-----NELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRT 346
Query: 1035 VKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLED-VKNMYKTQIDELLRQSLS 1093
+ + T+ L+Q+ + + + + AE R LE +K K +EL RQ S
Sbjct: 347 TAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS 406
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 124 bits (310), Expect = 6e-28
Identities = 169/753 (22%), Positives = 340/753 (45%), Gaps = 95/753 (12%)
Query: 376 KSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAE 435
K +E+ E ++ EA +EE + E+ + Q +LD + EQ E E
Sbjct: 916 KKQELEE--ILHEMEARLEEEEDRGQQLQAERKKM---------AQQMLD-LEEQLEEEE 963
Query: 436 SQPEALS-EKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESS 494
+ + L EK ++ L +++ + Q LSKE+ LLEE +L + +E++
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 495 SISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQ 554
+++ LK++ I+E E ++ K+ + +++E++ +K +L + +D EQ
Sbjct: 1024 NLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKL-----EGDASDF----HEQ 1070
Query: 555 IRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLN---KKVKELEEELQHLKQVL 611
I L + +L K QL ++L+A ++ +A+ N KK++ELE + L++ L
Sbjct: 1071 IADLQAQIAEL-KMQLAKKE--EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 612 D----GKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKEL 667
D + + EKQ R+ ++L ++ E L EL K L A E
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDS-TATQQELRAKREQEVTVLKKALDEE 1186
Query: 668 TDLHKANA----AKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRL 723
T H+A K ++A E L+ +++ + A L+K ++ ++ LA G+LR+
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVE-ELTEQLEQFKRAKANLDKNKQTLEKENADLA---GELRV 1242
Query: 724 ALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLG 783
L + +Q K+ L ++ ELQ + + E EL+ V L ++E++ L
Sbjct: 1243 -LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV----HKLQNEVESVTGMLN 1297
Query: 784 SQTSSWEKLEK---NLSDRLGESQTLL-------------AAAVERERAATEELLANKIQ 827
KL K +LS +L ++Q LL +E ER + ++ L +++
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1357
Query: 828 -MSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEY-VRTLEETR 885
++E S L + S + +L+ + + LE+ R+Q E+ENL +Y + +
Sbjct: 1358 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 886 KEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAG 945
EKT Q E++ + V+ + ++ + + +++K+RK + + S D A
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKYADERDRA- 1474
Query: 946 LQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQL 1005
+ E+ + + ++ +A +E LK ++ +
Sbjct: 1475 -------EAEAREKETKALSLARALEEALEA------KEELERTNKMLKAEMEDLVSSKD 1521
Query: 1006 EIG----NLEKTRSIMAEELVKLTNQNDELEEKVK--EIPKLRTQ--LRDLDQRYNTILQ 1057
++G LEK++ + ++ ++ Q +ELE++++ E KLR + ++ L ++ LQ
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 1058 MYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+ E+ EE R L+ + Y+T++++ +Q
Sbjct: 1582 ---ARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Score = 115 bits (289), Expect = 2e-25
Identities = 161/701 (22%), Positives = 303/701 (43%), Gaps = 103/701 (14%)
Query: 456 EKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEK-KV 514
E+++ +E +L + + E L+ + ++ EE + + T+ AEAE+ +V
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 515 QLACKERDAAKKEIKNIKEELATRLNSSETA--DLLKEKDEQIRGLME-----EGEKLSK 567
+LA K K+E++ I E+ RL E L E+ + + +++ E E+ ++
Sbjct: 912 RLAAK-----KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 568 QQLHNSNIIKKLRAKDKENENMVA-----KLNKKVKELEEELQHLKQVLDGKEEVEKQHR 622
Q+L + + + K E+E +V KL+K+ K LEE + L L +EE K
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 623 ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQ 682
+ K SM+ E L + + ELE+ R ++ ++++ DL +AQ
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL---------QAQ 1077
Query: 683 EAALSREM-KAKEELSAALEKAQEEARQQQETLAI------QVGDLRLALQRTEQAAARK 735
A L ++ K +EEL AAL + +E Q+ L + DL+ L +E+AA K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD-SERAARNK 1136
Query: 736 EDYLRHEIGELQQRLQEAENRNQELSQSVSST-TRPLLR-----QIENLQATLGSQTSSW 789
+ + ++GE E E EL ++ ST T+ LR ++ L+ L +T S
Sbjct: 1137 AEKQKRDLGE------ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 790 EKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLL----------R 839
E + + + ++ L +E+ + A L NK ++E +N+ L +
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK---QTLEKENADLAGELRVLGQAK 1247
Query: 840 QENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMER 899
QE + +LE++ L + R + EL ++ V L+ + T + ++ E +
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAEL----NDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 900 MKVEQE----RKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDE 955
+K+ ++ + TQE ++E+ R+ +VS+ S D + E
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 956 SHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLE-------IG 1008
H + + +S + L D +S +E L+ K + EI +L +
Sbjct: 1364 RHISTLN-IQLSDSKKKLQDF------ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 1009 NLEKTRSIMAEEL----VKLTNQN---DELEEKVKEIPKLRTQLRDLDQRY--------- 1052
LEKT++ + +EL V L NQ LE+K ++ +L + +++ +Y
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 1053 -----NTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELL 1088
T EEA E + +LE M K ++++L+
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Score = 108 bits (269), Expect = 4e-23
Identities = 227/1094 (20%), Positives = 441/1094 (40%), Gaps = 159/1094 (14%)
Query: 111 KSPVVSKPPAKSQRPEEEVKSSLHESLHIGQSRTPETTESQVK-DSSLCVSGETLAAGTS 169
K + K + Q+ E E+K E H + + Q++ ++ L E + +
Sbjct: 857 KEDELQKTKERQQKAENELKEL--EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914
Query: 170 SPKTEGKH-----EETVNKESD--MKVPTVSLKVSESVIDVKTTME----SISNTSTQSL 218
+ K E + E + +E D ++ K+++ ++D++ +E + + +
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 219 TAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQE 278
TAE K LE + +D Q+N S S + + E + + ++ E
Sbjct: 975 TAEAKIKKLEDEILVMDD-QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 279 TTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESC--CSSDAFERIDSFSVQSLD- 335
+ S+ + L + E + +KL +SD E+I Q +
Sbjct: 1034 SMISELEVRLKK------------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 336 ----SRSVSEINS-----DDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETL-- 384
++ E+ + DDE++ K AL K + EG ++ E L
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNAL------------KKIRELEGHISDLQEDLDS 1129
Query: 385 ---VIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQ-------TVLDKVA-EQCEP 433
E + + G + E D L S+ E + TVL K E+
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 434 AESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEES 493
E+Q + + +K + VE L E+LE+ + +L K K LE+ +L E+ + +
Sbjct: 1190 HEAQVQEMRQKH--AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 494 SSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEI-------KNIKEELATRLNSSETAD 546
+ K + ++ E + K C + + A+ E+ +N E + LN +E
Sbjct: 1248 QEVEHKKKKLEAQVQELQSK----CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 547 LLKEKD-----EQIRGLMEEGEKLSKQQLHNSNIIKKLRAK-----DKENENMVAK---- 592
+ KD Q++ E ++ ++Q+L+ S +++L + D+ +E M AK
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 593 -----LNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQ-------EKDLG 640
LN ++ + +++LQ ++ EE +K+ ++ I+ L E + EK
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 641 RLQVDMDELE---EKNRSIQAALDSAYKELTDL---HKANAAKDSEAQEAALSREMKAKE 694
RLQ ++D+L + R + + L+ ++ L K ++K ++ ++ A E + KE
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA-EAEAREKE 1482
Query: 695 ELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLR--HEIGE----LQQ 748
+ +L +A EEA + +E L L+ + E + K+D + HE+ + L+
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 749 RLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGS-QTSSWEKLEKNLSDRLGESQTLL 807
+++E + + +EL + +T LR N+QA G + + E+N R + L
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 808 AAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQ 867
E E + LA + L Q +S + + E+ K +L KL+ + +Q
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQ 1658
Query: 868 VELENLK---DEYVRTLEETRKEKTLLNS---QLEMERMKVEQERKKAIFTQETIKEKER 921
ELE+ + DE T +E K+ L + QL+ + E+ RK+A +E + E+
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 922 KPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANG-----SNLYDA 976
S+S + +A L+ L +++ + + A SN
Sbjct: 1719 S--SLSGRNALQDEKRRLEARIAQLEEE-LEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775
Query: 977 VRMGAGSSII-------ENLQSQLKLREGE----------ITHLQLEIGNLEKTRSIMAE 1019
R A + +N + + KL E E I L+ +I LE+ A
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 1020 ELVKLTNQNDELEEKVKEI-------PKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLD 1072
E T + ++K+KEI K+ Q ++ ++ N ++ + EEAEE
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 1073 LEDVKNMYKTQIDE 1086
+ + + ++DE
Sbjct: 1896 INANRRKLQRELDE 1909
Score = 61.6 bits (148), Expect = 4e-09
Identities = 62/282 (21%), Positives = 129/282 (45%), Gaps = 32/282 (11%)
Query: 439 EALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEE-SSSIS 497
+A + ++++ T + +K + EA L+ L ++ A E A E + EE +SS+S
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 498 ---SLKDE---FTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEK 551
+L+DE RIA+ E++++ +A ++ ++ N T +K
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 552 DEQIRGLMEEGEKLSKQQLHN---------SNIIKKLRAKDKENENMVAK-------LNK 595
+E R +E K + +LH + I L AK + E V + K
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 596 KVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRS 655
+K+ +++L+ + ++ + ++ +Q++E +K N+ V++ ++ L +E EE+++
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-------EEAEEESQR 1895
Query: 656 IQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELS 697
I A +EL + ++N A E AL +++ E S
Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVN--ALKSKLRRGNETS 1935
Score = 44.3 bits (103), Expect = 6e-04
Identities = 62/313 (19%), Positives = 135/313 (43%), Gaps = 31/313 (9%)
Query: 341 EINSDDELSGKGYALVPIIVNSSTPKS--KTVESAEGKSEEVNETLVIPTEEAEMEESGR 398
E+ +D + G+ A+ + + K + +E A +E+ T +E E +
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT----AKENEKKAKSL 1685
Query: 399 SATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALS-EKEDVCKTVEFLNEK 457
A + ++ D+ + + +++AE+ + S AL EK + + L E+
Sbjct: 1686 EADLMQLQE-DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 458 LEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKD-------EFTQRIAEA 510
LE+ + + ++S + + L +E+ + + S + E ++ E
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 511 EKKVQLACKERDAA-KKEIKNIKEELATRLNSSETADL-LKEKDEQIRGLM---EEGEKL 565
E V+ K AA + +I ++E++ + A LK+KD++++ ++ E+ K+
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 566 S---KQQLHNSNI-IKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQH 621
+ K+Q N +K+L+ + +E E ++N ++L+ EL + E E
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD------EATESNEAMG 1918
Query: 622 RENIKKLNSMVER 634
RE + L S + R
Sbjct: 1919 RE-VNALKSKLRR 1930
Score = 33.9 bits (76), Expect = 0.86
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 10/112 (8%)
Query: 985 IIENLQSQLKLREGEITHL------QLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEI 1038
I N + LKLR + L L++ E+ +EL K + + E ++KE+
Sbjct: 819 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL 878
Query: 1039 PKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+ +QL + LQ E EAEE+R+ L K +++E+L +
Sbjct: 879 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA----AKKQELEEILHE 926
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 124 bits (310), Expect = 6e-28
Identities = 169/753 (22%), Positives = 340/753 (45%), Gaps = 95/753 (12%)
Query: 376 KSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAE 435
K +E+ E ++ EA +EE + E+ + Q +LD + EQ E E
Sbjct: 923 KKQELEE--ILHEMEARLEEEEDRGQQLQAERKKM---------AQQMLD-LEEQLEEEE 970
Query: 436 SQPEALS-EKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESS 494
+ + L EK ++ L +++ + Q LSKE+ LLEE +L + +E++
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 495 SISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQ 554
+++ LK++ I+E E ++ K+ + +++E++ +K +L + +D EQ
Sbjct: 1031 NLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKL-----EGDASDF----HEQ 1077
Query: 555 IRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLN---KKVKELEEELQHLKQVL 611
I L + +L K QL ++L+A ++ +A+ N KK++ELE + L++ L
Sbjct: 1078 IADLQAQIAEL-KMQLAKKE--EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 612 D----GKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKEL 667
D + + EKQ R+ ++L ++ E L EL K L A E
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDS-TATQQELRAKREQEVTVLKKALDEE 1193
Query: 668 TDLHKANA----AKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRL 723
T H+A K ++A E L+ +++ + A L+K ++ ++ LA G+LR+
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVE-ELTEQLEQFKRAKANLDKNKQTLEKENADLA---GELRV 1249
Query: 724 ALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLG 783
L + +Q K+ L ++ ELQ + + E EL+ V L ++E++ L
Sbjct: 1250 -LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV----HKLQNEVESVTGMLN 1304
Query: 784 SQTSSWEKLEK---NLSDRLGESQTLL-------------AAAVERERAATEELLANKIQ 827
KL K +LS +L ++Q LL +E ER + ++ L +++
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1364
Query: 828 -MSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEY-VRTLEETR 885
++E S L + S + +L+ + + LE+ R+Q E+ENL +Y + +
Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 886 KEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAG 945
EKT Q E++ + V+ + ++ + + +++K+RK + + S D A
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKYADERDRA- 1481
Query: 946 LQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQL 1005
+ E+ + + ++ +A +E LK ++ +
Sbjct: 1482 -------EAEAREKETKALSLARALEEALEA------KEELERTNKMLKAEMEDLVSSKD 1528
Query: 1006 EIG----NLEKTRSIMAEELVKLTNQNDELEEKVK--EIPKLRTQ--LRDLDQRYNTILQ 1057
++G LEK++ + ++ ++ Q +ELE++++ E KLR + ++ L ++ LQ
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 1058 MYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+ E+ EE R L+ + Y+T++++ +Q
Sbjct: 1589 ---ARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Score = 115 bits (289), Expect = 2e-25
Identities = 161/701 (22%), Positives = 303/701 (43%), Gaps = 103/701 (14%)
Query: 456 EKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEK-KV 514
E+++ +E +L + + E L+ + ++ EE + + T+ AEAE+ +V
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 515 QLACKERDAAKKEIKNIKEELATRLNSSETA--DLLKEKDEQIRGLME-----EGEKLSK 567
+LA K K+E++ I E+ RL E L E+ + + +++ E E+ ++
Sbjct: 919 RLAAK-----KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 568 QQLHNSNIIKKLRAKDKENENMVA-----KLNKKVKELEEELQHLKQVLDGKEEVEKQHR 622
Q+L + + + K E+E +V KL+K+ K LEE + L L +EE K
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 623 ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQ 682
+ K SM+ E L + + ELE+ R ++ ++++ DL +AQ
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL---------QAQ 1084
Query: 683 EAALSREM-KAKEELSAALEKAQEEARQQQETLAI------QVGDLRLALQRTEQAAARK 735
A L ++ K +EEL AAL + +E Q+ L + DL+ L +E+AA K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD-SERAARNK 1143
Query: 736 EDYLRHEIGELQQRLQEAENRNQELSQSVSST-TRPLLR-----QIENLQATLGSQTSSW 789
+ + ++GE E E EL ++ ST T+ LR ++ L+ L +T S
Sbjct: 1144 AEKQKRDLGE------ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 790 EKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLL----------R 839
E + + + ++ L +E+ + A L NK ++E +N+ L +
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK---QTLEKENADLAGELRVLGQAK 1254
Query: 840 QENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMER 899
QE + +LE++ L + R + EL ++ V L+ + T + ++ E +
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAEL----NDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 900 MKVEQE----RKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDE 955
+K+ ++ + TQE ++E+ R+ +VS+ S D + E
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 956 SHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLE-------IG 1008
H + + +S + L D +S +E L+ K + EI +L +
Sbjct: 1371 RHISTLN-IQLSDSKKKLQDF------ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 1009 NLEKTRSIMAEEL----VKLTNQN---DELEEKVKEIPKLRTQLRDLDQRY--------- 1052
LEKT++ + +EL V L NQ LE+K ++ +L + +++ +Y
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 1053 -----NTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELL 1088
T EEA E + +LE M K ++++L+
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Score = 108 bits (269), Expect = 4e-23
Identities = 227/1094 (20%), Positives = 441/1094 (40%), Gaps = 159/1094 (14%)
Query: 111 KSPVVSKPPAKSQRPEEEVKSSLHESLHIGQSRTPETTESQVK-DSSLCVSGETLAAGTS 169
K + K + Q+ E E+K E H + + Q++ ++ L E + +
Sbjct: 864 KEDELQKTKERQQKAENELKEL--EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921
Query: 170 SPKTEGKH-----EETVNKESD--MKVPTVSLKVSESVIDVKTTME----SISNTSTQSL 218
+ K E + E + +E D ++ K+++ ++D++ +E + + +
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 219 TAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQE 278
TAE K LE + +D Q+N S S + + E + + ++ E
Sbjct: 982 TAEAKIKKLEDEILVMDD-QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 279 TTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESC--CSSDAFERIDSFSVQSLD- 335
+ S+ + L + E + +KL +SD E+I Q +
Sbjct: 1041 SMISELEVRLKK------------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 336 ----SRSVSEINS-----DDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETL-- 384
++ E+ + DDE++ K AL K + EG ++ E L
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNAL------------KKIRELEGHISDLQEDLDS 1136
Query: 385 ---VIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQ-------TVLDKVA-EQCEP 433
E + + G + E D L S+ E + TVL K E+
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 434 AESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEES 493
E+Q + + +K + VE L E+LE+ + +L K K LE+ +L E+ + +
Sbjct: 1197 HEAQVQEMRQKH--AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 494 SSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEI-------KNIKEELATRLNSSETAD 546
+ K + ++ E + K C + + A+ E+ +N E + LN +E
Sbjct: 1255 QEVEHKKKKLEAQVQELQSK----CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 547 LLKEKD-----EQIRGLMEEGEKLSKQQLHNSNIIKKLRAK-----DKENENMVAK---- 592
+ KD Q++ E ++ ++Q+L+ S +++L + D+ +E M AK
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 593 -----LNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQ-------EKDLG 640
LN ++ + +++LQ ++ EE +K+ ++ I+ L E + EK
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 641 RLQVDMDELE---EKNRSIQAALDSAYKELTDL---HKANAAKDSEAQEAALSREMKAKE 694
RLQ ++D+L + R + + L+ ++ L K ++K ++ ++ A E + KE
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA-EAEAREKE 1489
Query: 695 ELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLR--HEIGE----LQQ 748
+ +L +A EEA + +E L L+ + E + K+D + HE+ + L+
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 749 RLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGS-QTSSWEKLEKNLSDRLGESQTLL 807
+++E + + +EL + +T LR N+QA G + + E+N R + L
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 808 AAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQ 867
E E + LA + L Q +S + + E+ K +L KL+ + +Q
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQ 1665
Query: 868 VELENLK---DEYVRTLEETRKEKTLLNS---QLEMERMKVEQERKKAIFTQETIKEKER 921
ELE+ + DE T +E K+ L + QL+ + E+ RK+A +E + E+
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 922 KPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANG-----SNLYDA 976
S+S + +A L+ L +++ + + A SN
Sbjct: 1726 S--SLSGRNALQDEKRRLEARIAQLEEE-LEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782
Query: 977 VRMGAGSSII-------ENLQSQLKLREGE----------ITHLQLEIGNLEKTRSIMAE 1019
R A + +N + + KL E E I L+ +I LE+ A
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 1020 ELVKLTNQNDELEEKVKEI-------PKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLD 1072
E T + ++K+KEI K+ Q ++ ++ N ++ + EEAEE
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 1073 LEDVKNMYKTQIDE 1086
+ + + ++DE
Sbjct: 1903 INANRRKLQRELDE 1916
Score = 61.6 bits (148), Expect = 4e-09
Identities = 62/282 (21%), Positives = 129/282 (45%), Gaps = 32/282 (11%)
Query: 439 EALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEE-SSSIS 497
+A + ++++ T + +K + EA L+ L ++ A E A E + EE +SS+S
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 498 ---SLKDE---FTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEK 551
+L+DE RIA+ E++++ +A ++ ++ N T +K
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 552 DEQIRGLMEEGEKLSKQQLHN---------SNIIKKLRAKDKENENMVAK-------LNK 595
+E R +E K + +LH + I L AK + E V + K
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 596 KVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRS 655
+K+ +++L+ + ++ + ++ +Q++E +K N+ V++ ++ L +E EE+++
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-------EEAEEESQR 1902
Query: 656 IQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELS 697
I A +EL + ++N A E AL +++ E S
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVN--ALKSKLRRGNETS 1942
Score = 44.3 bits (103), Expect = 6e-04
Identities = 62/313 (19%), Positives = 135/313 (43%), Gaps = 31/313 (9%)
Query: 341 EINSDDELSGKGYALVPIIVNSSTPKS--KTVESAEGKSEEVNETLVIPTEEAEMEESGR 398
E+ +D + G+ A+ + + K + +E A +E+ T +E E +
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT----AKENEKKAKSL 1692
Query: 399 SATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALS-EKEDVCKTVEFLNEK 457
A + ++ D+ + + +++AE+ + S AL EK + + L E+
Sbjct: 1693 EADLMQLQE-DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 458 LEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKD-------EFTQRIAEA 510
LE+ + + ++S + + L +E+ + + S + E ++ E
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 511 EKKVQLACKERDAA-KKEIKNIKEELATRLNSSETADL-LKEKDEQIRGLM---EEGEKL 565
E V+ K AA + +I ++E++ + A LK+KD++++ ++ E+ K+
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 566 S---KQQLHNSNI-IKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQH 621
+ K+Q N +K+L+ + +E E ++N ++L+ EL + E E
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD------EATESNEAMG 1925
Query: 622 RENIKKLNSMVER 634
RE + L S + R
Sbjct: 1926 RE-VNALKSKLRR 1937
Score = 33.9 bits (76), Expect = 0.86
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 10/112 (8%)
Query: 985 IIENLQSQLKLREGEITHL------QLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEI 1038
I N + LKLR + L L++ E+ +EL K + + E ++KE+
Sbjct: 826 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL 885
Query: 1039 PKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+ +QL + LQ E EAEE+R+ L K +++E+L +
Sbjct: 886 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA----AKKQELEEILHE 933
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 124 bits (310), Expect = 6e-28
Identities = 169/753 (22%), Positives = 340/753 (45%), Gaps = 95/753 (12%)
Query: 376 KSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAE 435
K +E+ E ++ EA +EE + E+ + Q +LD + EQ E E
Sbjct: 923 KKQELEE--ILHEMEARLEEEEDRGQQLQAERKKM---------AQQMLD-LEEQLEEEE 970
Query: 436 SQPEALS-EKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESS 494
+ + L EK ++ L +++ + Q LSKE+ LLEE +L + +E++
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 495 SISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQ 554
+++ LK++ I+E E ++ K+ + +++E++ +K +L + +D EQ
Sbjct: 1031 NLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKL-----EGDASDF----HEQ 1077
Query: 555 IRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLN---KKVKELEEELQHLKQVL 611
I L + +L K QL ++L+A ++ +A+ N KK++ELE + L++ L
Sbjct: 1078 IADLQAQIAEL-KMQLAKKE--EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 612 D----GKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKEL 667
D + + EKQ R+ ++L ++ E L EL K L A E
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDS-TATQQELRAKREQEVTVLKKALDEE 1193
Query: 668 TDLHKANA----AKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRL 723
T H+A K ++A E L+ +++ + A L+K ++ ++ LA G+LR+
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVE-ELTEQLEQFKRAKANLDKNKQTLEKENADLA---GELRV 1249
Query: 724 ALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLG 783
L + +Q K+ L ++ ELQ + + E EL+ V L ++E++ L
Sbjct: 1250 -LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV----HKLQNEVESVTGMLN 1304
Query: 784 SQTSSWEKLEK---NLSDRLGESQTLL-------------AAAVERERAATEELLANKIQ 827
KL K +LS +L ++Q LL +E ER + ++ L +++
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1364
Query: 828 -MSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEY-VRTLEETR 885
++E S L + S + +L+ + + LE+ R+Q E+ENL +Y + +
Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 886 KEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAG 945
EKT Q E++ + V+ + ++ + + +++K+RK + + S D A
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKYADERDRA- 1481
Query: 946 LQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQL 1005
+ E+ + + ++ +A +E LK ++ +
Sbjct: 1482 -------EAEAREKETKALSLARALEEALEA------KEELERTNKMLKAEMEDLVSSKD 1528
Query: 1006 EIG----NLEKTRSIMAEELVKLTNQNDELEEKVK--EIPKLRTQ--LRDLDQRYNTILQ 1057
++G LEK++ + ++ ++ Q +ELE++++ E KLR + ++ L ++ LQ
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 1058 MYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+ E+ EE R L+ + Y+T++++ +Q
Sbjct: 1589 ---ARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Score = 115 bits (289), Expect = 2e-25
Identities = 161/701 (22%), Positives = 303/701 (43%), Gaps = 103/701 (14%)
Query: 456 EKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEK-KV 514
E+++ +E +L + + E L+ + ++ EE + + T+ AEAE+ +V
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 515 QLACKERDAAKKEIKNIKEELATRLNSSETA--DLLKEKDEQIRGLME-----EGEKLSK 567
+LA K K+E++ I E+ RL E L E+ + + +++ E E+ ++
Sbjct: 919 RLAAK-----KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 568 QQLHNSNIIKKLRAKDKENENMVA-----KLNKKVKELEEELQHLKQVLDGKEEVEKQHR 622
Q+L + + + K E+E +V KL+K+ K LEE + L L +EE K
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 623 ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQ 682
+ K SM+ E L + + ELE+ R ++ ++++ DL +AQ
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL---------QAQ 1084
Query: 683 EAALSREM-KAKEELSAALEKAQEEARQQQETLAI------QVGDLRLALQRTEQAAARK 735
A L ++ K +EEL AAL + +E Q+ L + DL+ L +E+AA K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD-SERAARNK 1143
Query: 736 EDYLRHEIGELQQRLQEAENRNQELSQSVSST-TRPLLR-----QIENLQATLGSQTSSW 789
+ + ++GE E E EL ++ ST T+ LR ++ L+ L +T S
Sbjct: 1144 AEKQKRDLGE------ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 790 EKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLL----------R 839
E + + + ++ L +E+ + A L NK ++E +N+ L +
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK---QTLEKENADLAGELRVLGQAK 1254
Query: 840 QENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMER 899
QE + +LE++ L + R + EL ++ V L+ + T + ++ E +
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAEL----NDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 900 MKVEQE----RKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDE 955
+K+ ++ + TQE ++E+ R+ +VS+ S D + E
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 956 SHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLE-------IG 1008
H + + +S + L D +S +E L+ K + EI +L +
Sbjct: 1371 RHISTLN-IQLSDSKKKLQDF------ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 1009 NLEKTRSIMAEEL----VKLTNQN---DELEEKVKEIPKLRTQLRDLDQRY--------- 1052
LEKT++ + +EL V L NQ LE+K ++ +L + +++ +Y
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 1053 -----NTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELL 1088
T EEA E + +LE M K ++++L+
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Score = 108 bits (269), Expect = 4e-23
Identities = 227/1094 (20%), Positives = 441/1094 (40%), Gaps = 159/1094 (14%)
Query: 111 KSPVVSKPPAKSQRPEEEVKSSLHESLHIGQSRTPETTESQVK-DSSLCVSGETLAAGTS 169
K + K + Q+ E E+K E H + + Q++ ++ L E + +
Sbjct: 864 KEDELQKTKERQQKAENELKEL--EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921
Query: 170 SPKTEGKH-----EETVNKESD--MKVPTVSLKVSESVIDVKTTME----SISNTSTQSL 218
+ K E + E + +E D ++ K+++ ++D++ +E + + +
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 219 TAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQE 278
TAE K LE + +D Q+N S S + + E + + ++ E
Sbjct: 982 TAEAKIKKLEDEILVMDD-QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 279 TTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESC--CSSDAFERIDSFSVQSLD- 335
+ S+ + L + E + +KL +SD E+I Q +
Sbjct: 1041 SMISELEVRLKK------------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 336 ----SRSVSEINS-----DDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETL-- 384
++ E+ + DDE++ K AL K + EG ++ E L
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNAL------------KKIRELEGHISDLQEDLDS 1136
Query: 385 ---VIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQ-------TVLDKVA-EQCEP 433
E + + G + E D L S+ E + TVL K E+
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 434 AESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEES 493
E+Q + + +K + VE L E+LE+ + +L K K LE+ +L E+ + +
Sbjct: 1197 HEAQVQEMRQKH--AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 494 SSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEI-------KNIKEELATRLNSSETAD 546
+ K + ++ E + K C + + A+ E+ +N E + LN +E
Sbjct: 1255 QEVEHKKKKLEAQVQELQSK----CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 547 LLKEKD-----EQIRGLMEEGEKLSKQQLHNSNIIKKLRAK-----DKENENMVAK---- 592
+ KD Q++ E ++ ++Q+L+ S +++L + D+ +E M AK
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 593 -----LNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQ-------EKDLG 640
LN ++ + +++LQ ++ EE +K+ ++ I+ L E + EK
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 641 RLQVDMDELE---EKNRSIQAALDSAYKELTDL---HKANAAKDSEAQEAALSREMKAKE 694
RLQ ++D+L + R + + L+ ++ L K ++K ++ ++ A E + KE
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA-EAEAREKE 1489
Query: 695 ELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLR--HEIGE----LQQ 748
+ +L +A EEA + +E L L+ + E + K+D + HE+ + L+
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 749 RLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGS-QTSSWEKLEKNLSDRLGESQTLL 807
+++E + + +EL + +T LR N+QA G + + E+N R + L
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 808 AAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQ 867
E E + LA + L Q +S + + E+ K +L KL+ + +Q
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQ 1665
Query: 868 VELENLK---DEYVRTLEETRKEKTLLNS---QLEMERMKVEQERKKAIFTQETIKEKER 921
ELE+ + DE T +E K+ L + QL+ + E+ RK+A +E + E+
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 922 KPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANG-----SNLYDA 976
S+S + +A L+ L +++ + + A SN
Sbjct: 1726 S--SLSGRNALQDEKRRLEARIAQLEEE-LEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782
Query: 977 VRMGAGSSII-------ENLQSQLKLREGE----------ITHLQLEIGNLEKTRSIMAE 1019
R A + +N + + KL E E I L+ +I LE+ A
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 1020 ELVKLTNQNDELEEKVKEI-------PKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLD 1072
E T + ++K+KEI K+ Q ++ ++ N ++ + EEAEE
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 1073 LEDVKNMYKTQIDE 1086
+ + + ++DE
Sbjct: 1903 INANRRKLQRELDE 1916
Score = 60.1 bits (144), Expect = 1e-08
Identities = 58/265 (21%), Positives = 122/265 (46%), Gaps = 30/265 (11%)
Query: 439 EALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEE-SSSIS 497
+A + ++++ T + +K + EA L+ L ++ A E A E + EE +SS+S
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 498 ---SLKDE---FTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEK 551
+L+DE RIA+ E++++ +A ++ ++ N T +K
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 552 DEQIRGLMEEGEKLSKQQLHN---------SNIIKKLRAKDKENENMVAK-------LNK 595
+E R +E K + +LH + I L AK + E V + K
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 596 KVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRS 655
+K+ +++L+ + ++ + ++ +Q++E +K N+ V++ ++ L +E EE+++
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-------EEAEEESQR 1902
Query: 656 IQAALDSAYKELTDLHKANAAKDSE 680
I A +EL + ++N A E
Sbjct: 1903 INANRRKLQRELDEATESNEAMGRE 1927
Score = 33.9 bits (76), Expect = 0.86
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 10/112 (8%)
Query: 985 IIENLQSQLKLREGEITHL------QLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEI 1038
I N + LKLR + L L++ E+ +EL K + + E ++KE+
Sbjct: 826 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL 885
Query: 1039 PKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+ +QL + LQ E EAEE+R+ L K +++E+L +
Sbjct: 886 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA----AKKQELEEILHE 933
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 124 bits (310), Expect = 6e-28
Identities = 169/753 (22%), Positives = 340/753 (45%), Gaps = 95/753 (12%)
Query: 376 KSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAE 435
K +E+ E ++ EA +EE + E+ + Q +LD + EQ E E
Sbjct: 916 KKQELEE--ILHEMEARLEEEEDRGQQLQAERKKM---------AQQMLD-LEEQLEEEE 963
Query: 436 SQPEALS-EKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESS 494
+ + L EK ++ L +++ + Q LSKE+ LLEE +L + +E++
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 495 SISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQ 554
+++ LK++ I+E E ++ K+ + +++E++ +K +L + +D EQ
Sbjct: 1024 NLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKL-----EGDASDF----HEQ 1070
Query: 555 IRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLN---KKVKELEEELQHLKQVL 611
I L + +L K QL ++L+A ++ +A+ N KK++ELE + L++ L
Sbjct: 1071 IADLQAQIAEL-KMQLAKKE--EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 612 D----GKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKEL 667
D + + EKQ R+ ++L ++ E L EL K L A E
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDS-TATQQELRAKREQEVTVLKKALDEE 1186
Query: 668 TDLHKANA----AKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRL 723
T H+A K ++A E L+ +++ + A L+K ++ ++ LA G+LR+
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVE-ELTEQLEQFKRAKANLDKNKQTLEKENADLA---GELRV 1242
Query: 724 ALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLG 783
L + +Q K+ L ++ ELQ + + E EL+ V L ++E++ L
Sbjct: 1243 -LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV----HKLQNEVESVTGMLN 1297
Query: 784 SQTSSWEKLEK---NLSDRLGESQTLL-------------AAAVERERAATEELLANKIQ 827
KL K +LS +L ++Q LL +E ER + ++ L +++
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1357
Query: 828 -MSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEY-VRTLEETR 885
++E S L + S + +L+ + + LE+ R+Q E+ENL +Y + +
Sbjct: 1358 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 886 KEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAG 945
EKT Q E++ + V+ + ++ + + +++K+RK + + S D A
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKYADERDRA- 1474
Query: 946 LQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQL 1005
+ E+ + + ++ +A +E LK ++ +
Sbjct: 1475 -------EAEAREKETKALSLARALEEALEA------KEELERTNKMLKAEMEDLVSSKD 1521
Query: 1006 EIG----NLEKTRSIMAEELVKLTNQNDELEEKVK--EIPKLRTQ--LRDLDQRYNTILQ 1057
++G LEK++ + ++ ++ Q +ELE++++ E KLR + ++ L ++ LQ
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 1058 MYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+ E+ EE R L+ + Y+T++++ +Q
Sbjct: 1582 ---ARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Score = 115 bits (289), Expect = 2e-25
Identities = 161/701 (22%), Positives = 303/701 (43%), Gaps = 103/701 (14%)
Query: 456 EKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEK-KV 514
E+++ +E +L + + E L+ + ++ EE + + T+ AEAE+ +V
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 515 QLACKERDAAKKEIKNIKEELATRLNSSETA--DLLKEKDEQIRGLME-----EGEKLSK 567
+LA K K+E++ I E+ RL E L E+ + + +++ E E+ ++
Sbjct: 912 RLAAK-----KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 568 QQLHNSNIIKKLRAKDKENENMVA-----KLNKKVKELEEELQHLKQVLDGKEEVEKQHR 622
Q+L + + + K E+E +V KL+K+ K LEE + L L +EE K
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 623 ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQ 682
+ K SM+ E L + + ELE+ R ++ ++++ DL +AQ
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL---------QAQ 1077
Query: 683 EAALSREM-KAKEELSAALEKAQEEARQQQETLAI------QVGDLRLALQRTEQAAARK 735
A L ++ K +EEL AAL + +E Q+ L + DL+ L +E+AA K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD-SERAARNK 1136
Query: 736 EDYLRHEIGELQQRLQEAENRNQELSQSVSST-TRPLLR-----QIENLQATLGSQTSSW 789
+ + ++GE E E EL ++ ST T+ LR ++ L+ L +T S
Sbjct: 1137 AEKQKRDLGE------ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 790 EKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLL----------R 839
E + + + ++ L +E+ + A L NK ++E +N+ L +
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK---QTLEKENADLAGELRVLGQAK 1247
Query: 840 QENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMER 899
QE + +LE++ L + R + EL ++ V L+ + T + ++ E +
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAEL----NDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 900 MKVEQE----RKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDE 955
+K+ ++ + TQE ++E+ R+ +VS+ S D + E
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 956 SHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLE-------IG 1008
H + + +S + L D +S +E L+ K + EI +L +
Sbjct: 1364 RHISTLN-IQLSDSKKKLQDF------ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 1009 NLEKTRSIMAEEL----VKLTNQN---DELEEKVKEIPKLRTQLRDLDQRY--------- 1052
LEKT++ + +EL V L NQ LE+K ++ +L + +++ +Y
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 1053 -----NTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELL 1088
T EEA E + +LE M K ++++L+
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Score = 108 bits (269), Expect = 4e-23
Identities = 227/1094 (20%), Positives = 441/1094 (40%), Gaps = 159/1094 (14%)
Query: 111 KSPVVSKPPAKSQRPEEEVKSSLHESLHIGQSRTPETTESQVK-DSSLCVSGETLAAGTS 169
K + K + Q+ E E+K E H + + Q++ ++ L E + +
Sbjct: 857 KEDELQKTKERQQKAENELKEL--EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914
Query: 170 SPKTEGKH-----EETVNKESD--MKVPTVSLKVSESVIDVKTTME----SISNTSTQSL 218
+ K E + E + +E D ++ K+++ ++D++ +E + + +
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 219 TAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQE 278
TAE K LE + +D Q+N S S + + E + + ++ E
Sbjct: 975 TAEAKIKKLEDEILVMDD-QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 279 TTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESC--CSSDAFERIDSFSVQSLD- 335
+ S+ + L + E + +KL +SD E+I Q +
Sbjct: 1034 SMISELEVRLKK------------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 336 ----SRSVSEINS-----DDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETL-- 384
++ E+ + DDE++ K AL K + EG ++ E L
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNAL------------KKIRELEGHISDLQEDLDS 1129
Query: 385 ---VIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQ-------TVLDKVA-EQCEP 433
E + + G + E D L S+ E + TVL K E+
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 434 AESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEES 493
E+Q + + +K + VE L E+LE+ + +L K K LE+ +L E+ + +
Sbjct: 1190 HEAQVQEMRQKH--AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 494 SSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEI-------KNIKEELATRLNSSETAD 546
+ K + ++ E + K C + + A+ E+ +N E + LN +E
Sbjct: 1248 QEVEHKKKKLEAQVQELQSK----CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 547 LLKEKD-----EQIRGLMEEGEKLSKQQLHNSNIIKKLRAK-----DKENENMVAK---- 592
+ KD Q++ E ++ ++Q+L+ S +++L + D+ +E M AK
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 593 -----LNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQ-------EKDLG 640
LN ++ + +++LQ ++ EE +K+ ++ I+ L E + EK
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 641 RLQVDMDELE---EKNRSIQAALDSAYKELTDL---HKANAAKDSEAQEAALSREMKAKE 694
RLQ ++D+L + R + + L+ ++ L K ++K ++ ++ A E + KE
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA-EAEAREKE 1482
Query: 695 ELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLR--HEIGE----LQQ 748
+ +L +A EEA + +E L L+ + E + K+D + HE+ + L+
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 749 RLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGS-QTSSWEKLEKNLSDRLGESQTLL 807
+++E + + +EL + +T LR N+QA G + + E+N R + L
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 808 AAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQ 867
E E + LA + L Q +S + + E+ K +L KL+ + +Q
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQ 1658
Query: 868 VELENLK---DEYVRTLEETRKEKTLLNS---QLEMERMKVEQERKKAIFTQETIKEKER 921
ELE+ + DE T +E K+ L + QL+ + E+ RK+A +E + E+
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 922 KPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANG-----SNLYDA 976
S+S + +A L+ L +++ + + A SN
Sbjct: 1719 S--SLSGRNALQDEKRRLEARIAQLEEE-LEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775
Query: 977 VRMGAGSSII-------ENLQSQLKLREGE----------ITHLQLEIGNLEKTRSIMAE 1019
R A + +N + + KL E E I L+ +I LE+ A
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 1020 ELVKLTNQNDELEEKVKEI-------PKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLD 1072
E T + ++K+KEI K+ Q ++ ++ N ++ + EEAEE
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 1073 LEDVKNMYKTQIDE 1086
+ + + ++DE
Sbjct: 1896 INANRRKLQRELDE 1909
Score = 60.1 bits (144), Expect = 1e-08
Identities = 58/265 (21%), Positives = 122/265 (46%), Gaps = 30/265 (11%)
Query: 439 EALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEE-SSSIS 497
+A + ++++ T + +K + EA L+ L ++ A E A E + EE +SS+S
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 498 ---SLKDE---FTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEK 551
+L+DE RIA+ E++++ +A ++ ++ N T +K
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 552 DEQIRGLMEEGEKLSKQQLHN---------SNIIKKLRAKDKENENMVAK-------LNK 595
+E R +E K + +LH + I L AK + E V + K
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 596 KVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRS 655
+K+ +++L+ + ++ + ++ +Q++E +K N+ V++ ++ L +E EE+++
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-------EEAEEESQR 1895
Query: 656 IQAALDSAYKELTDLHKANAAKDSE 680
I A +EL + ++N A E
Sbjct: 1896 INANRRKLQRELDEATESNEAMGRE 1920
Score = 33.9 bits (76), Expect = 0.86
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 10/112 (8%)
Query: 985 IIENLQSQLKLREGEITHL------QLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEI 1038
I N + LKLR + L L++ E+ +EL K + + E ++KE+
Sbjct: 819 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL 878
Query: 1039 PKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+ +QL + LQ E EAEE+R+ L K +++E+L +
Sbjct: 879 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA----AKKQELEEILHE 926
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 118 bits (295), Expect = 3e-26
Identities = 143/666 (21%), Positives = 283/666 (42%), Gaps = 55/666 (8%)
Query: 451 VEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEA 510
++ L KLEK E + L LE L E+ + S S L D T A
Sbjct: 1263 IQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRA 1322
Query: 511 EKKVQLACKERDAAKKEIKNIKEEL-------ATRLNSSETAD------------LLKEK 551
EK+++ + DA KK+++ ++ E+ A +N D ++E
Sbjct: 1323 EKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREV 1382
Query: 552 DEQIRGLMEEGE-KLSKQQLHNSNIIKK---LRAKDKENENMVAKLNKKVKELEEELQHL 607
D + L +E E KL +Q + + ++ L+A +E++ + +L KK + L ELQ
Sbjct: 1383 DFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDT 1442
Query: 608 KQVLDGKE----EVEKQHR---ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAAL 660
K L+G++ E+EK+ R + + + +R++ +LQ + D L + S++ L
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQL 1502
Query: 661 DSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQ-----EEARQQQETLA 715
+ ++ + + ++E Q+ + ++K+E S A K Q + + Q+E L
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDIS---SQESKDEASLAKVKKQLRDLEAKVKDQEEELD 1559
Query: 716 IQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQI 775
Q G +++ Q + E + E++ R +E E Q + + L +
Sbjct: 1560 EQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY 1619
Query: 776 ENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQN 835
E+ Q L + KL LSD++ + ++ T+ LLA+ M +
Sbjct: 1620 EDKQKVLREKRELEGKL-ATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNS 1678
Query: 836 SLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQL 895
+ ++E ++ + QLE + +VE+E+L + +++ K KT L QL
Sbjct: 1679 APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQ----IDDIAKAKTALEEQL 1734
Query: 896 EMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDE 955
+ + + + + QE + E +K ++ SR + A L+ + + E
Sbjct: 1735 SRLQREKNEIQNRLEEDQEDMNELMKK--HKAAVAQASRDLAQINDLQAQLEEANKEKQE 1792
Query: 956 SHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRS 1015
+ + A S + + S++ +++++ E + + ++ LE S
Sbjct: 1793 LQE------KLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLAS 1846
Query: 1016 IMAEELVKLTNQNDE---LEEKVKEIPK-LRTQLRDLDQRYNTILQMYGEKAEEAEELRL 1071
+ E + KLT + D+ E + KE K L+ QLRD + + + E + + EL +
Sbjct: 1847 RLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEM 1906
Query: 1072 DLEDVK 1077
DLE ++
Sbjct: 1907 DLESLE 1912
Score = 74.3 bits (181), Expect = 6e-13
Identities = 102/472 (21%), Positives = 209/472 (44%), Gaps = 44/472 (9%)
Query: 424 LDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLK 483
L+ + ES+ EA K V K + L K++ +E +L + +LE+A L+
Sbjct: 1519 LEAELQDISSQESKDEASLAK--VKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLE 1576
Query: 484 DEMFRVKEESSSISSLKDEFTQRIAEA----EKKVQLACKERDAAKKEIKNIKEELATRL 539
EM R+++ S +DE + ++ K++++ +E K+++ K EL +L
Sbjct: 1577 MEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKL 1636
Query: 540 NSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKE 599
+ +D + +D + + + K +K L ++ ++ ++ +A+L +++E
Sbjct: 1637 --ATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEE 1694
Query: 600 LEEELQHLKQVLDGKE-EVEKQHR--ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSI 656
E + E E+E H ++I K + +E Q L RLQ EKN I
Sbjct: 1695 SEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQ---LSRLQ------REKN-EI 1744
Query: 657 QAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAI 716
Q L+ +++ +L K + A ++A SR++ +L A LE+A +E ++ QE L
Sbjct: 1745 QNRLEEDQEDMNELMKKHKAAVAQA-----SRDLAQINDLQAQLEEANKEKQELQEKLQA 1799
Query: 717 QVGDLRLALQRTEQAAARKEDYLRHE--IGELQQRLQEAENRNQELSQSVSSTTRPLLRQ 774
L+ ++ EQ+ K R E I EL+ RL+ + + L S + +
Sbjct: 1800 ----LQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKL 1855
Query: 775 IENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQ 834
E + ++ E+ K L +L +++ + +E A+ + ++ + S+E+
Sbjct: 1856 TEERDQRIAAENREKEQ-NKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAA 1914
Query: 835 NSLLRQE-----------NSRFQAQLESEKNRLCKLEDENNRYQVELENLKD 875
N L+ + + + ++ES++N + ++ ELE+ D
Sbjct: 1915 NQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDRVD 1966
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 118 bits (295), Expect = 3e-26
Identities = 143/666 (21%), Positives = 283/666 (42%), Gaps = 55/666 (8%)
Query: 451 VEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEA 510
++ L KLEK E + L LE L E+ + S S L D T A
Sbjct: 1263 IQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRA 1322
Query: 511 EKKVQLACKERDAAKKEIKNIKEEL-------ATRLNSSETAD------------LLKEK 551
EK+++ + DA KK+++ ++ E+ A +N D ++E
Sbjct: 1323 EKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREV 1382
Query: 552 DEQIRGLMEEGE-KLSKQQLHNSNIIKK---LRAKDKENENMVAKLNKKVKELEEELQHL 607
D + L +E E KL +Q + + ++ L+A +E++ + +L KK + L ELQ
Sbjct: 1383 DFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDT 1442
Query: 608 KQVLDGKE----EVEKQHR---ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAAL 660
K L+G++ E+EK+ R + + + +R++ +LQ + D L + S++ L
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQL 1502
Query: 661 DSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQ-----EEARQQQETLA 715
+ ++ + + ++E Q+ + ++K+E S A K Q + + Q+E L
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDIS---SQESKDEASLAKVKKQLRDLEAKVKDQEEELD 1559
Query: 716 IQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQI 775
Q G +++ Q + E + E++ R +E E Q + + L +
Sbjct: 1560 EQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY 1619
Query: 776 ENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQN 835
E+ Q L + KL LSD++ + ++ T+ LLA+ M +
Sbjct: 1620 EDKQKVLREKRELEGKL-ATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNS 1678
Query: 836 SLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQL 895
+ ++E ++ + QLE + +VE+E+L + +++ K KT L QL
Sbjct: 1679 APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQ----IDDIAKAKTALEEQL 1734
Query: 896 EMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDE 955
+ + + + + QE + E +K ++ SR + A L+ + + E
Sbjct: 1735 SRLQREKNEIQNRLEEDQEDMNELMKK--HKAAVAQASRDLAQINDLQAQLEEANKEKQE 1792
Query: 956 SHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRS 1015
+ + A S + + S++ +++++ E + + ++ LE S
Sbjct: 1793 LQE------KLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLAS 1846
Query: 1016 IMAEELVKLTNQNDE---LEEKVKEIPK-LRTQLRDLDQRYNTILQMYGEKAEEAEELRL 1071
+ E + KLT + D+ E + KE K L+ QLRD + + + E + + EL +
Sbjct: 1847 RLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEM 1906
Query: 1072 DLEDVK 1077
DLE ++
Sbjct: 1907 DLESLE 1912
Score = 76.6 bits (187), Expect = 1e-13
Identities = 103/475 (21%), Positives = 211/475 (44%), Gaps = 46/475 (9%)
Query: 424 LDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLK 483
L+ + ES+ EA K V K + L K++ +E +L + +LE+A L+
Sbjct: 1519 LEAELQDISSQESKDEASLAK--VKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLE 1576
Query: 484 DEMFRVKEESSSISSLKDEFTQRIAEA----EKKVQLACKERDAAKKEIKNIKEELATRL 539
EM R+++ S +DE + ++ K++++ +E K+++ K EL +L
Sbjct: 1577 MEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKL 1636
Query: 540 NSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKE 599
+ +D + +D + + + K +K L ++ ++ ++ +A+L +++E
Sbjct: 1637 --ATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEE 1694
Query: 600 LEEELQHLKQVLDGKE-EVEKQHR--ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSI 656
E + E E+E H ++I K + +E Q L RLQ EKN I
Sbjct: 1695 SEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQ---LSRLQ------REKN-EI 1744
Query: 657 QAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAI 716
Q L+ +++ +L K + A ++A SR++ +L A LE+A +E ++ QE L
Sbjct: 1745 QNRLEEDQEDMNELMKKHKAAVAQA-----SRDLAQINDLQAQLEEANKEKQELQEKLQA 1799
Query: 717 QVGDLRLALQRTEQAAARKEDYLRHE--IGELQQRLQEAENRNQELSQSVSSTTRPLLRQ 774
L+ ++ EQ+ K R E I EL+ RL+ + + L S + +
Sbjct: 1800 ----LQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKL 1855
Query: 775 IENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQ 834
E + ++ E+ K L +L +++ + +E A+ + ++ + S+E+
Sbjct: 1856 TEERDQRIAAENREKEQ-NKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAA 1914
Query: 835 NSLLRQE-----------NSRFQAQLESEKNR--LCKLEDENNRYQVELENLKDE 876
N L+ + + + ++ES++N + L+D +YQ L+ +
Sbjct: 1915 NQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGD 1969
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 117 bits (294), Expect = 5e-26
Identities = 146/683 (21%), Positives = 293/683 (42%), Gaps = 70/683 (10%)
Query: 429 EQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFR 488
+ C + L +K + V L +L+ ++ +E+ + + L+ +
Sbjct: 601 QACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNE 660
Query: 489 VKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLL 548
EE+S++ +E + + +++ ER+ + EI++++++L+ + ++A
Sbjct: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSA--- 717
Query: 549 KEKDEQIRGLMEEGEKLSKQQLHNSNIIKK-----LRAKDKENENMVAKLNKKVKELEEE 603
K +++ +G + E +KQ L + I K+ LR +++E + L ++V ++E
Sbjct: 718 KRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQE 777
Query: 604 LQHLKQVLDGK----EEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAA 659
+ LK+ D + E ++ +N++ L S E+D ++ + L+E+N +Q
Sbjct: 778 MDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGR 837
Query: 660 LDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVG 719
+ + + L + +D + EA +K E LE+A AR++++ +
Sbjct: 838 SEELERRVAQLQRQ--IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEK----EAV 891
Query: 720 DLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQ 779
R AL+ +AA E +L ++L+E + ++L R L ++EN +
Sbjct: 892 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL--------RRLKNEMENER 943
Query: 780 ATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLR 839
LG EKL+K ++D VE R +T EL N++ +++ L
Sbjct: 944 WHLGKTI---EKLQKEMAD-----------IVEASRTSTLEL-QNQLDEYKEKNRRELAE 988
Query: 840 QENSRFQAQLESEKNRLC--KLEDENNRYQVEL---ENLKDEYV---RTLEETRKE---K 888
+ + LE+EK+RL K++DE + EL + +DE + + LE+T K+ +
Sbjct: 989 MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
Query: 889 TLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQT 948
S L+ +R ++ ++ + + E E+ER +++ +S S S M L+
Sbjct: 1049 LEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER-----NNSDLLSERISRSREQMEQLRN 1103
Query: 949 SFLSQDESH-DHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEI 1007
L + + D + + +L S II S +EG + ++ I
Sbjct: 1104 ELLQERAARQDLECDKISLERQNKDLK--------SRIIHLEGSYRSSKEGLVVQMEARI 1155
Query: 1008 GNLEKTRSIMAEELVKLTNQNDELEEKVKE----IPKLRTQLRDLDQRYNTILQMYGEKA 1063
LE + L N LE KVKE + L D + + L+ +
Sbjct: 1156 AELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQV 1215
Query: 1064 EEAEELRLDLEDVKNMYKTQIDE 1086
EEAEE LE K + +++E
Sbjct: 1216 EEAEEEIDRLESSKKKLQRELEE 1238
Score = 99.8 bits (247), Expect = 1e-20
Identities = 177/884 (20%), Positives = 353/884 (39%), Gaps = 139/884 (15%)
Query: 171 PKTEGKHEETVNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPK 230
P +GK ET + + SL ++ E T+T +L + + A P
Sbjct: 464 PNIDGKVLETEGSQESTVIRAPSL-------GAQSKKEEEVKTATATLMLQNRATATSP- 515
Query: 231 EQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSASS----------RQETT 280
S V TF S ++T + ++L + +++ + ++ +T
Sbjct: 516 -------DSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGST 568
Query: 281 DS----KSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDS 336
D+ K ++L+ Q L + A Q ++C S+ + D +S +
Sbjct: 569 DNDDATKRKVNLVFEKIQTLKSRAA------GSAQGNNQACNSTSEVK--DLLEQKSKLT 620
Query: 337 RSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAE---- 392
V+E+ +L K + + + S + E N TL EE+E
Sbjct: 621 IEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELR 680
Query: 393 --MEESGRSATPVNCEQPDILVSSTPINEGQTVLD--KVAEQCEPAESQPEALSEKEDVC 448
+EE + Q +I ++E LD K +E E E L K+D+
Sbjct: 681 KNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQ 740
Query: 449 KTV---EFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEE-SSSISSLKDEFT 504
+ E + L KRE +L +L K L+E + EM ++KE+ + + +L++
Sbjct: 741 DLLIAKEEQEDLLRKRERELTAL---KGALKEEVSSHDQEMDKLKEQYDAELQALRES-- 795
Query: 505 QRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEK 564
+ EA K V++ + ++++ + + LL+E++E+++G EE E+
Sbjct: 796 --VEEATKNVEVLASRSNTSEQD----------QAGTEMRVKLLQEENEKLQGRSEELER 843
Query: 565 LSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHL----KQVLDGKEEVEK- 619
Q +K AK KE + K ++++LEE L H K+ + + +E
Sbjct: 844 RVAQLQRQIEDLKGDEAKAKET---LKKYEGEIRQLEEALVHARKEEKEAVSARRALENE 900
Query: 620 ---------QHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDL 670
Q + K+L+ ++ + + +L+ +E+E + + ++ KE+ D+
Sbjct: 901 LEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI 960
Query: 671 HKANAAKDSEAQE-------------AALSREMKAKEELSAALEKAQEEARQQQETLAIQ 717
+A+ E Q A + R++K K + EK++ A + Q+ + +
Sbjct: 961 VEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEK---TLEAEKSRLTAMKMQDEMRLM 1017
Query: 718 VGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIEN 777
+LR QR + A K L + +L+ L+ + + S+ V + + ++
Sbjct: 1018 EEELR-DYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLV----KQMEDKVSQ 1072
Query: 778 LQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSL 837
L+ L + ++ + L + +S R E L + +ERAA ++L +KI S+E QN
Sbjct: 1073 LEMELEEERNNSDLLSERIS-RSREQMEQLRNELLQERAARQDLECDKI---SLERQNKD 1128
Query: 838 LRQENSRFQAQLESEKN--------RLCKLED-----ENNRYQVELEN--LKDEYVRTLE 882
L+ + S K R+ +LED E +R ++L N L+ + +
Sbjct: 1129 LKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVM 1188
Query: 883 ETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIK--EKERKPFSVSSTPTMSRSSSISG 940
+ E L Q + ++++ +++ +E I E +K M + + G
Sbjct: 1189 QVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQG 1248
Query: 941 --------VDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDA 976
+ + L + L + D +S +G +LY+A
Sbjct: 1249 QLNSMKKDLRLKKLPSKVLDDMDDDD------DLSTDGGSLYEA 1286
Score = 59.3 bits (142), Expect = 2e-08
Identities = 107/565 (18%), Positives = 223/565 (39%), Gaps = 97/565 (17%)
Query: 561 EGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQ 620
+ +K + + + ++ + RA ++ K++ K Q +L G++E+ +Q
Sbjct: 490 QSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQ 549
Query: 621 HRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSE 680
E K + L D D+ ++ ++ ++++ L K+ AA ++
Sbjct: 550 TNEETAK-----QILYNYLKEGSTDNDDATKRKVNL------VFEKIQTL-KSRAAGSAQ 597
Query: 681 AQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQ---RTEQAAARKED 737
A + + K+ L +Q+ L I+V +L+ LQ + +Q + +
Sbjct: 598 GNNQACNSTSEVKDLL------------EQKSKLTIEVAELQRQLQLEVKNQQNIKEERE 645
Query: 738 YLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLS 797
+R + EL+ + E N L Q + + L + +E L + ++ ++L
Sbjct: 646 RMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEI-RDLQ 704
Query: 798 DRLGESQTLLAAAV---ERERAAT-EELLANKIQMSSM----ESQNSLLRQENSRFQAQL 849
D+L E L +A +RE+ A EELL K + + E Q LLR+ A
Sbjct: 705 DQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALK 764
Query: 850 ESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRK--EKTLLNSQLEMERMKVEQERK 907
+ L++E + + E++ LK++Y L+ R+ E+ N ++ R ++ +
Sbjct: 765 GA-------LKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQ 817
Query: 908 KAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPIS 967
+ + ++E + S R + + Q L DE+
Sbjct: 818 AGTEMRVKLLQEENEKLQGRSEELERRVAQLQR------QIEDLKGDEAK---------- 861
Query: 968 ANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELV----- 1022
++ + +++ E + H + E R + EL
Sbjct: 862 --------------AKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGN 907
Query: 1023 --KLTNQNDELEEKVKEIPKLRTQLRDL-----DQRYN---TILQMYGEKAEEAE----- 1067
+ T + +L EK+KE + + QLR L ++R++ TI ++ E A+ E
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS 967
Query: 1068 --ELRLDLEDVKNMYKTQIDELLRQ 1090
EL+ L++ K + ++ E+ RQ
Sbjct: 968 TLELQNQLDEYKEKNRRELAEMQRQ 992
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 115 bits (289), Expect = 2e-25
Identities = 187/903 (20%), Positives = 368/903 (40%), Gaps = 140/903 (15%)
Query: 250 SSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASACPEYNRLDD 309
+ GT + E+ +++I E + QE D + + ++Q + Q
Sbjct: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQ--------------- 244
Query: 310 FQKLTESCCS-----SDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSST 364
QKLTE SD ERI+ L I +D + + ++
Sbjct: 245 -QKLTEISRRHREELSDYEERIEELE-NLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKV 302
Query: 365 PKSKTVESAEGKSEEVNETL--------VIPTEEAEMEESGRSATPVNCE---------Q 407
+K +E E K +++N+ L ++ E+ ++ R CE Q
Sbjct: 303 ESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIME-ECENLKLECSKLQ 361
Query: 408 PDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLE------KR 461
P + S + E + +L + A E Q +ALS+ E+ + LN+ K
Sbjct: 362 PSAVKQSDTMTEKERILAQSASVEEVFRLQ-QALSDAENEIMRLSSLNQDNSLAEDNLKL 420
Query: 462 EAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEA-EKKVQLACKE 520
+ ++ L KEK+LL + + L+ + ++ E I S +E + ++ L KE
Sbjct: 421 KMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKE 480
Query: 521 RDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLR 580
+ E+ E T + +E +L ++ E + ++ ++LSKQQ +II KL+
Sbjct: 481 Q-----ELNQSISEKETLI--AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLK 533
Query: 581 AKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLG 640
+ + V +L ++ +EL K+ L E +KL VE L
Sbjct: 534 QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLN 593
Query: 641 RLQVDMDELEEKNRSIQAALDSAYKELTDLH---------------KANAAKDSEAQEAA 685
+ Q ++++N ++ + +EL+ + K K+ EA+
Sbjct: 594 KSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653
Query: 686 LSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQR----TEQAAARKE---DY 738
L + + E+L+ L+K + + + E L + D+R L+ Q + K +
Sbjct: 654 LKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVET 713
Query: 739 LRHEIGELQ-------QRLQEAENRN----QELSQSVSSTTRPLLRQIENLQATLGSQTS 787
L+ E GE++ +RL E N+ +ELS + + T L + E+L +
Sbjct: 714 LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDM 773
Query: 788 SWEKLEKNLSDR---LGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSR 844
+L+KN+ E++ +L++++E ++ T+ + +I + ++ ++S L++E +
Sbjct: 774 EIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDK 833
Query: 845 FQAQLE---------SEKNR-LCKLEDENNRYQVELENLKDEYVRT-----------LEE 883
+ L EK+R L +++ENN Q ELE L++E RT + E
Sbjct: 834 YSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTE 893
Query: 884 TRKEKTLLNS-------QLEMERMKVEQERKKAIFTQETIKE--KERKPF-----SVSST 929
E + LN+ +++ + +E + + + ++++E KE F +++T
Sbjct: 894 LASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNAT 953
Query: 930 PT---MSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSII 986
T + + I + Q +E D I + S+++ ++ S I
Sbjct: 954 HTQLFLEKDEEIKSLQKTIEQIKTQLHEERQD-------IQTDNSDIFQETKV--QSLNI 1004
Query: 987 ENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLR 1046
EN + L + E L I E ++ E+ + LT Q D+L + E+ KL ++
Sbjct: 1005 ENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSK--DEVGKLTQIIQ 1062
Query: 1047 DLD 1049
D
Sbjct: 1063 QKD 1065
Score = 85.1 bits (209), Expect = 3e-16
Identities = 176/930 (18%), Positives = 368/930 (39%), Gaps = 160/930 (17%)
Query: 135 ESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGK---HEETVNKESDMKVPT 191
E L QSRT + + DS ++ E T E + H++ + ++ K+
Sbjct: 870 ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQL 929
Query: 192 V-SLKVSESVID-VKTTMESISNTSTQSLTAETKDIAL------EPKEQKHEDRQSNTPS 243
+ SL+ + +D + E ++ T TQ + ++I + K Q HE+RQ
Sbjct: 930 LQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQD---- 985
Query: 244 PPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSA---SA 300
+ T +S + ++ L+ E+ SE S+ ET + + +LL+ S
Sbjct: 986 --IQTDNSDIFQETKVQSLNIENG-SEKHDLSKAETERLVKGIKERELEIKLLNEKNISL 1042
Query: 301 CPEYNRL--DDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDD----ELSGKGYA 354
+ ++L D+ KLT+ D +Q+L +R S ++ D + + YA
Sbjct: 1043 TKQIDQLSKDEVGKLTQIIQQKD-------LEIQALHARISSTSHTQDVVYLQQQLQAYA 1095
Query: 355 LVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEM----EESGRSATPVNCEQPDI 410
+ V + KT E++ K+E ++ +EA + +E+ + +T D+
Sbjct: 1096 MEREKV-FAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDM 1154
Query: 411 LVS-----STPINEGQTVLDKVAEQCEP------------------AESQPEALSEKEDV 447
S I E +D ++++C+ + E L E++ +
Sbjct: 1155 FRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKL 1214
Query: 448 CKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSI----------- 496
+ V+ + E ++ + ++ E A L+E L+ ++ + +S +
Sbjct: 1215 KQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSY 1274
Query: 497 ----SSLKDEFTQRIAEAEKKVQLACKERD----------------------------AA 524
+ LK+ F Q +A+ + + C +D A+
Sbjct: 1275 EQNETKLKN-FGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRAS 1333
Query: 525 KKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLS-----------KQQLHNS 573
K E+ + EL + E L+EKD IR L E +LS K+
Sbjct: 1334 KSEVLSESSELLQQ-ELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTD 1392
Query: 574 NIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVE 633
+ IK+L+ K + ++ + + +K ++L + K + R+ + L +
Sbjct: 1393 SEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIL 1452
Query: 634 RQEKDLGRLQVDMDELEEKNRSIQA---ALDSAYKELTDLHKANAAKDSEAQEAALSREM 690
E D+G+L+ + +++ E R + AL + + + + + +E AL+ E
Sbjct: 1453 ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQ 1512
Query: 691 KAKE----------ELSAALEKAQEEA-----RQQQETLAIQVGDLR-LALQRTEQAAAR 734
KE +L A++ QE+ + Q LA++ + ALQ Q
Sbjct: 1513 LLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRD 1572
Query: 735 KEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLE- 793
KE E+ L+ L E+E+ + + L +++ L+ L S +++ E
Sbjct: 1573 KEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASH 1632
Query: 794 ------KNLSDRLG-----ESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQEN 842
++L ++L +T L +V +E+ L +QM Q ++E
Sbjct: 1633 QASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ----QEEK 1688
Query: 843 SRFQAQLESEKNRLCKLEDENNRYQ---VELENLKDEYVRTLEETRKEKTLLNSQLEMER 899
+ + A+LE +K + + + + + L+ DE L+ + L QL+++
Sbjct: 1689 AMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASR----LTEQLDVKE 1744
Query: 900 MKVEQERKKAIFTQETIKEKERKPFSVSST 929
++E+ +++ QE + + ++K S++++
Sbjct: 1745 EQIEELKRQNELRQEMLDDVQKKLMSLANS 1774
Score = 80.9 bits (198), Expect = 6e-15
Identities = 116/580 (20%), Positives = 239/580 (41%), Gaps = 98/580 (16%)
Query: 553 EQIRGLMEEGEKLSKQQLHNSNIIKKLRAK--DKENENMVAKLNKKVKELEE-------E 603
++I L E +L + H +I + +A+ D +++ + KL +KEL++ +
Sbjct: 172 QEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDD 231
Query: 604 LQHLKQVLDGKE-----EVEKQHRENIKKLNSMVERQEKDL-----GRLQVDMDELEEKN 653
QH VL E+ ++HRE + +E E L G ++ D+ ++ E
Sbjct: 232 HQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQ 291
Query: 654 RSIQAALDSAYKELTDLHKANAAKDSEAQEAAL---SREMKAKEELSAALEKAQEEARQQ 710
++IQ + + K + K E E + ++++ + E L + QE+ +
Sbjct: 292 KTIQ---------VLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVE 342
Query: 711 QETLAIQVGDLRLALQRTEQAAARKEDYLRH------------EIGELQQRLQEAENRNQ 758
+ + + +L+L + + +A ++ D + E+ LQQ L +AEN
Sbjct: 343 KRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIM 402
Query: 759 ELSQ-----SVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVER 813
LS S++ L +IE L+ + E+L+ +L +L ++ + R
Sbjct: 403 RLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLL-KLNNEYEVIKSTATR 461
Query: 814 ERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENL 873
+ + EL ++ + + E + + E A++E +L+ +N + +
Sbjct: 462 DISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIE-------ELDRQNQEATKHMILI 514
Query: 874 KDEYVRTLEETRKEKTLLNSQLEMERMKVEQ-ERKKAIFTQETIKEKERKPFSVSSTPTM 932
KD+ + E + L L E+ +V Q E K T+E +KE+
Sbjct: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKL---------- 564
Query: 933 SRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQ 992
S+ +D + NL D + S++ ++Q +
Sbjct: 565 -----------------IQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNV--SIQKE 605
Query: 993 -LKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDE---LEEKVKEIPKLRTQLRDL 1048
L+L+E H++ L + R+ + + L + +N N + L+E+ E+ L+ L +L
Sbjct: 606 NLELKE----HIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
Query: 1049 DQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELL 1088
+Q + ++ + E E+L L EDV++ Q++E L
Sbjct: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRH----QLEECL 697
Score = 65.5 bits (158), Expect = 3e-10
Identities = 104/523 (19%), Positives = 227/523 (43%), Gaps = 66/523 (12%)
Query: 243 SPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASACP 302
SP +S+ S T +++ V+SESS +QE + + SL + + L
Sbjct: 1313 SPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQ----- 1367
Query: 303 EYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNS 362
++ +L++S ++ ER + S + ++ ++ K +++ +
Sbjct: 1368 -----ENNHRLSDSIAATSELERKEHEQTDS----EIKQLKEKQDVLQKLLKEKDLLIKA 1418
Query: 363 STPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQT 422
+ + + S E + +VNE ++ ++E IL+ I + +
Sbjct: 1419 KS--DQLLSSNENFTNKVNENELLRQAVTNLKER-------------ILILEMDIGKLKG 1463
Query: 423 VLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNL 482
+K+ E E++ +AL E T + L ++E + S+ KEKAL AF+ L
Sbjct: 1464 ENEKIVETYRGKETEYQALQE------TNMKFSMMLREKEFECHSM-KEKAL---AFEQL 1513
Query: 483 KDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSS 542
+KE+ + ++ + ++K + +ERD +K + E N++
Sbjct: 1514 ------LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQME-----NTA 1562
Query: 543 ETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKK--LRAKDKENENMVAKLNKKVKEL 600
++ + +D++ R +E E+L L + + + L A+D+E AKL KKV L
Sbjct: 1563 LQNEVQRLRDKEFRS-NQELERLRNHLLESEDSYTREALAAEDRE-----AKLRKKVTVL 1616
Query: 601 EEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAA- 659
EE+L ++ E++++ ++V +Q +D LQ+ + + + K ++ A
Sbjct: 1617 EEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQ-RDETALQLSVSQEQVKQYALSLAN 1675
Query: 660 LDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSA---ALEKAQEEARQQQETLAI 716
L + KA + + E Q+ ++ K E L +L++ +EA ++ +
Sbjct: 1676 LQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASR 1735
Query: 717 QVGDLRLALQRTEQAAARKEDYLRHE-IGELQQRLQEAENRNQ 758
L + ++ E+ ++++ LR E + ++Q++L N ++
Sbjct: 1736 LTEQLDVKEEQIEE--LKRQNELRQEMLDDVQKKLMSLANSSE 1776
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 114 bits (286), Expect = 4e-25
Identities = 173/781 (22%), Positives = 338/781 (43%), Gaps = 100/781 (12%)
Query: 362 SSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQP---------DILV 412
++T ++ AE + EEV + T E E + + V E D LV
Sbjct: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 413 SSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEK 472
S + Q ++ + + + + + +D+ + E L ++++ +Q+ + +
Sbjct: 542 SKQQLE--QRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSAS 599
Query: 473 ALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAE-------------KKVQLACK 519
L EE + ++ ++K+ S++S +D T + E + +K+Q
Sbjct: 600 VLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALAN 659
Query: 520 ERDAAKKEIKNIKEELATRLNSSETADLLKEK-DEQIRGLMEEGEKLSKQQLHNSNIIKK 578
E+ AA E++ +++ + + + LL+E+ +I MEE + L+ Q + ++K
Sbjct: 660 EQAAAAHELEKMQQSVYVK---DDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
Query: 579 LRA--KDKENENMVAKLNKKVKELEEELQHLKQVLD-GKEEVEKQHRE--NIKKLNSMVE 633
L+ ++ N+++V ++ K ++E +E+L+ ++++L+ G +V + E I+ NS +
Sbjct: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 634 RQEKDLGRLQ---VDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAA--LSR 688
++ +DL Q V L E+ + + D K + +L +A K + ++ L +
Sbjct: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Query: 689 EMKA-KEEL-SAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGEL 746
E+KA KEE+ + LEKAQ Q ++ +V +L+ L+ E+ + L + +L
Sbjct: 837 EIKALKEEIGNVQLEKAQ------QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL 890
Query: 747 QQR---LQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGES 803
LQ+ + N+ L V + L++ S S +E+LE L ++ E
Sbjct: 891 ANTGKWLQDLQEENESLKAHVQEVAQHNLKE--------ASSASQFEELEIVLKEKENEL 942
Query: 804 QTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQ---ENSRFQAQLESEKNRLCKLE 860
+ L A ERE S + S+ LL+ EN F++Q+E K
Sbjct: 943 KRLEAMLKERE--------------SDLSSKTQLLQDVQDENKLFKSQIEQLK------- 981
Query: 861 DENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIK--E 918
+ N Q +E ++ + E KE + L ++L+ + VE +RKK Q+ ++ E
Sbjct: 982 -QQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVE 1040
Query: 919 KERKPFSVSSTPTMSRSSSIS-GVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAV 977
E K P +S S++S G + G + E + G + L +A
Sbjct: 1041 LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKK---AKECMAGTSGSEEVKVLEHKLKEAD 1097
Query: 978 RMGAGSSI-IENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQ-NDELEEKV 1035
M + E +S L EG + LQ + E + +E K Q
Sbjct: 1098 EMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE 1157
Query: 1036 KEIPKLRTQLRDLD--QRYNTILQMYGEKAE--------EAEELRLDLEDVKNMYKTQID 1085
+E+ +LR++ +D++ +R L+M EKAE E EL+ L + +T+ +
Sbjct: 1158 QELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQN 1217
Query: 1086 E 1086
E
Sbjct: 1218 E 1218
Score = 97.1 bits (240), Expect = 8e-20
Identities = 142/674 (21%), Positives = 288/674 (42%), Gaps = 46/674 (6%)
Query: 265 ESVISESS--ASSRQETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDA 322
+S+ SE S +E D ++ L++ Q L A A + + +K+ +S D
Sbjct: 621 DSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDD 680
Query: 323 FERIDSFSVQSLDSRSVSE--INSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEV 380
R+ +Q S + E I +D + K + S P VE E +E
Sbjct: 681 KIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK 740
Query: 381 NETLVIPTEEAEMEESGRSATPVNCEQPDIL--VSSTPINEGQTVLDKVAEQCEPA---E 435
+E L T E E+ E+G E+ + + +S+ E Q + K +Q A E
Sbjct: 741 DEKL--KTVE-ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797
Query: 436 SQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSS 495
+ + EK+ K+VE E EA+LL ++ + E+ +LK E+ +KEE +
Sbjct: 798 ELKKVIHEKDGKIKSVE------ELLEAELLKVANK----EKTVQDLKQEIKALKEEIGN 847
Query: 496 ISSLKDE---FTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKD 552
+ K + T ++ E + ++ ++ + K ++ +++LA N+ + L+E++
Sbjct: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA---NTGKWLQDLQEEN 904
Query: 553 EQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLD 612
E ++ ++E + + ++ +++ ++L KE EN + +L +KE E +L Q+L
Sbjct: 905 ESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQ 964
Query: 613 GKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHK 672
++ K + I++L +Q + + + E+ + I + L + L D +
Sbjct: 965 DVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEI-SGLWNELDSLKDAVE 1023
Query: 673 ANAAKDSEAQEAALSREMKAKEELSAALEKAQEEA------------RQQQETLAIQVGD 720
K++E Q+ + E++AKE L K + ++ +E +A G
Sbjct: 1024 HQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS 1083
Query: 721 LRL-ALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQ 779
+ L+ + A L+ E + + L E E Q+L +SV +++
Sbjct: 1084 EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESH 1143
Query: 780 ATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLR 839
T+ SS+ E+ L E++ + ERE EL +++ S+ ++ L+
Sbjct: 1144 KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEM-ELEKAEMERSTYVTEVRELK 1202
Query: 840 QENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMER 899
+ + +L +E+N K+ + ++ Q LE ++ + V+ +T + NS + E
Sbjct: 1203 AQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDT---TVIENSDVSPET 1259
Query: 900 MKVEQERKKAIFTQ 913
E+E Q
Sbjct: 1260 ESSEKETMSVSLNQ 1273
Score = 92.4 bits (228), Expect = 2e-18
Identities = 153/816 (18%), Positives = 344/816 (42%), Gaps = 102/816 (12%)
Query: 334 LDSRSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEM 393
+D R V ++ D++ G I S T K KT E + + L+
Sbjct: 246 VDKREVIDLLKPDQVEG--------IQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFS 297
Query: 394 EESGRSATPVNCEQPDIL---VSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCK- 449
E+ + E+ ++ + + E T++ ++ E+ + + E + +D CK
Sbjct: 298 EDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ 357
Query: 450 -TVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIA 508
T E + EK +R +++ K++ E N+ V + + +K F Q
Sbjct: 358 LTQEMMTEK--ERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK--FQQVRE 413
Query: 509 EAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQ 568
+ E ++ +E + + N +L ++ S+E L ++ + L E+ KL ++
Sbjct: 414 QMEAEIAHLKQENGILRDAVSNTTNQLESK-QSAELNKLRQDYARLVNELTEKTGKLQQE 472
Query: 569 QLHNSNIIK-------KLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKE-EVEKQ 620
++ N + +L+ ++ E + + + K+ E E Q L+ KE EV+
Sbjct: 473 EVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL 532
Query: 621 H----------RENIKKLNSMVERQEKDLGR---LQVDMDELEEKNRSIQAALDSAYKEL 667
H ++ ++L ++E ++K + + LQ+ + ++ E+N +++A + + ++
Sbjct: 533 HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 668 T----------DLHKANAAKDSEAQ--EAALSRE---MKAKEELSAALEKAQ---EEARQ 709
+LHK A KD + + E +L+ E + +KEE ++ + Q
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 710 QQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTR 769
+ + LA + L++ +Q+ K+D +R L+++LQ + E + ++ +
Sbjct: 653 KLQALANEQAAAAHELEKMQQSVYVKDDKIR----LLEEQLQHEISNKMEEFKILNDQNK 708
Query: 770 PLLRQIENLQATLGSQTSS--WEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQ 827
L +++ LQ + Q + E++EK + ++ E+ + E L IQ
Sbjct: 709 ALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK-----------DEKLKTVEELLETGLIQ 757
Query: 828 MSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENL------KDEYVRTL 881
+++ E + + +R ENS +++ K + +++ + +E L KD ++++
Sbjct: 758 VATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFASLVEELKKVIHEKDGKIKSV 813
Query: 882 EE---------TRKEKTLLNSQLEMERMKVE---QERKKAIFTQETIKEKERKPFSVSST 929
EE KEKT+ + + E++ +K E + +KA T K +E +
Sbjct: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873
Query: 930 PTMSRSSSISGVDMAGLQTS--FLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIE 987
M+ ++ L + +L + + S NL +A + +S E
Sbjct: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA----SSASQFE 929
Query: 988 NLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRD 1047
L+ LK +E E+ L+ + E S + L + ++N + +++++ + Q
Sbjct: 930 ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS 989
Query: 1048 LDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQ 1083
+ +L++ E+ +E L +L+ +K+ + Q
Sbjct: 990 SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 114 bits (286), Expect = 4e-25
Identities = 171/789 (21%), Positives = 334/789 (42%), Gaps = 106/789 (13%)
Query: 369 TVESAEG------KSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQT 422
TV+S EG K E+ N+ L E E E + NC+ S + + +
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN-----LSKDLMKEKA 536
Query: 423 VLDKVAEQC-EPAESQPEALS-EKEDVCKTVEFLNEKLE-KREAQLLSLSKEKALLEEAF 479
L+K E E +E Q + L E E + +TV L ++ + EA++ + KE +L E+
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
Query: 480 DNLKDEMFRVKEESSSISSLKDEFTQ---RIAEAEKKVQLACKERDAAKKEIKNIKEELA 536
++ +++ E I + + + R E E ++ KE + +K+I N+K
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI--- 653
Query: 537 TRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAK---L 593
T + ++ +++ L E KL K N+ +L + +KEN + + L
Sbjct: 654 -------TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 594 NKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKN 653
+ V+ L+ + Q+ +E+E + +E +KK +++ K RL+V L+ +N
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESE-KEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 654 RSIQAALDSAYK-------ELTDLHKANAAKDSEAQEAALS--------REMKAKEELSA 698
+ +Q L+++ K EL DL N +E +S +E K+ E+ ++
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 699 ALEKAQEEARQQQETLAIQ--VGDLRLALQRTEQAAARKEDY-LRHEIGELQQ---RLQE 752
LEK +++ ++ + L Q + D L + KE+ L EIG ++ RL+E
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Query: 753 AENRNQELSQSVSSTTRPLLRQIENL---QATLGSQTSSWEKLEKNLSDRLGESQTLLAA 809
E N+EL + + + L+ E+L + + EKL L +++G ++ L
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL-EKIGLNKERLLH 944
Query: 810 AVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVE 869
+ + +LL +K++ S+++ + ++ + +A+LE N N + + E
Sbjct: 945 DEQSTDDSRYKLLESKLE-STLKKSLEIKEEKIAALEARLEESTNY-------NQQLRQE 996
Query: 870 LENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSST 929
L+ +K Y L++ + E+ ++ S + + ER+ T+E +K K+R +
Sbjct: 997 LKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 930 PTMSRSSSISGVDMAGLQT-----------------SFLSQDESHDHSFGPMPISANGSN 972
T+ + L+T S Q+ + + + + N
Sbjct: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115
Query: 973 LYDAVRMGAG-------SSIIENLQSQLKLREGEITHLQLEIGNLEKTRSI---MAEELV 1022
M SS+ +S +K RE + I + EK + A E
Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
Query: 1023 KLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKT 1082
L +++ L+ K L + RDL+ RYN +L+ G+ LED++ M K
Sbjct: 1176 SLISKHGTLKSAHKN---LEVEHRDLEDRYNQLLKQKGQ-----------LEDLEKMLKV 1221
Query: 1083 QIDELLRQS 1091
+ +++L ++
Sbjct: 1222 EQEKMLLEN 1230
Score = 103 bits (258), Expect = 7e-22
Identities = 216/1014 (21%), Positives = 419/1014 (41%), Gaps = 136/1014 (13%)
Query: 130 KSSLHESLHIGQ-----SRTPETTES--------------------QVKDSSLCVSGETL 164
K S+ ESLH+G SRT E +E+ ++++ SL + E L
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 479
Query: 165 AAGTSSPKTEGKHEETVNKESDMKVPTVSLKVSES-VIDVKTTMESISNTS--------- 214
T+ EG + + E + + + +++ E+ ++ K ++++ N S
Sbjct: 480 R--TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
Query: 215 ---TQSLTAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLD---HESVI 268
T E + ++ EQ++E S + S + DIE + HES+
Sbjct: 538 LEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 269 SESSASSRQETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDAFERIDS 328
SS S+ E K + ++ A N L +K E +I
Sbjct: 598 ETSSKLSKIEF--EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC 655
Query: 329 FSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNE-TLVIP 387
+++L+ + SE+ ++ K ++S + +ES E ++ +++E L +
Sbjct: 656 EKIEALEQEN-SELERENRKLKK-------TLDSFKNLTFQLESLEKENSQLDEENLELR 707
Query: 388 TEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALS-EKED 446
++ + + E ++ + +G +L ++ E E + L E +
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQR 767
Query: 447 VCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQR 506
+ KT+E N+K+++ E++L L E L++ + LK R+++ SL+ E +Q
Sbjct: 768 LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ- 826
Query: 507 IAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLS 566
E+D KK+++ + L + +T L+E + +I L +E + LS
Sbjct: 827 ------------LEKD--KKQLEKENKRLRQQAEIKDTT--LEENNVKIGNLEKENKTLS 870
Query: 567 KQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIK 626
K+ +L+ +KEN+ +V + +K L L++ L ++ +Q +++
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVT----LREDLVSEKLKTQQMNNDLE 926
Query: 627 KLNSMVERQEKDLGRLQVDMDELEE-KNRSIQAALDSAYKELTDLHKAN-AAKDSEAQEA 684
KL +E+ + RL D ++ + + +++ L+S K+ ++ + AA ++ +E+
Sbjct: 927 KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 986
Query: 685 A-----LSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYL 739
L +E+K ++ AL++ Q+E R Q + I D + +R Q R
Sbjct: 987 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK--WERESQETTR----- 1039
Query: 740 RHEIGELQQRLQEAENRNQEL---SQSVSSTTRPLLRQIENLQA---TLGSQTSSWEKLE 793
E+ +++ RL E E N L Q++ + + L Q NLQA L QT S ++
Sbjct: 1040 --ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1097
Query: 794 KNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEK 853
L + + Q + + + + IQ SS+E++N + +E ++ +S
Sbjct: 1098 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1157
Query: 854 NRLCKLEDENNRYQVELENLKDEY-------------VRTLEETRKEKTLLNSQLE-MER 899
KLE + R E E+L ++ R LE+ + QLE +E+
Sbjct: 1158 KDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1217
Query: 900 M-KVEQERK-KAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESH 957
M KVEQE+ ET+ + +K + + S + +T L D +
Sbjct: 1218 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK-------ETEVLQTDHKN 1270
Query: 958 DHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEI-----GNLEK 1012
S N S L + R+ A S ++ QL + ++ + Q E+ GNLE+
Sbjct: 1271 LKSL------LNNSKL-EQTRLEAEFSKLKEQYQQLDITSTKLNN-QCELLSQLKGNLEE 1322
Query: 1013 TRSIMAEELVKLTNQNDELEEKVKEIPKL-RTQLRDLDQRYNTILQMYGEKAEE 1065
+ +++ L QN L E+ E L + R + N L+ EK EE
Sbjct: 1323 ENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNE-LRRQKEKLEE 1375
Score = 102 bits (253), Expect = 3e-21
Identities = 140/644 (21%), Positives = 281/644 (43%), Gaps = 69/644 (10%)
Query: 493 SSSISSLKDEFTQRIAEAEKKVQ--LACK-ERDAAKKEIKNIKEELATRLNSSETADLLK 549
S ++ K + + E E+K + L CK E + + E+K +++E L+ + +A + +
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 550 EKDEQIRGLMEEGEKLS------KQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEE 603
++ + +R +KL K++LH+ K R ++ + +N V K + LE++
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKA-RVEELKEDNQVLLETKTM--LEDQ 366
Query: 604 LQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSA 663
L+ + D E+EK++ + KL+ M E+D+ R +++ EL E+N +++ A +
Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDM--EMERDMDRKKIE--ELMEENMTLEMAQKQS 422
Query: 664 YKE-------LTDLHKANAAKDS-------EAQEAALSREMKAKEELSAALEKAQEEARQ 709
E L + + + ++ E E SR +K + E + +L K EE R
Sbjct: 423 MDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME-NQSLTKTVEELRT 481
Query: 710 QQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTR 769
+++ + L +++ Q ++K + L +EI + +Q LQ +N +++L + + +
Sbjct: 482 TVDSVEGNASKI-LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 770 PLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAV----ERERAATEELLANK 825
+ EN + + E L + +S SQ A V + + E +
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 826 IQMSSMESQNSLLRQENSRFQ---AQLESEKNRLCKLEDENNRYQVELENLK--DEYVRT 880
++S +E + +++E ++ + E +N L LE EN Q ++ NLK E +
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 881 LEETRKEKTLLNSQLEMERMKVEQ---ERKKAIFTQETIKEKERKPFSVSSTPTMSRSSS 937
LE+ NS+LE E K+++ K F E++ EKE + S
Sbjct: 661 LEQE-------NSELERENRKLKKTLDSFKNLTFQLESL-EKENSQLDEENLELRRNVES 712
Query: 938 I--SGVDMAGLQ---TSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAG------SSII 986
+ + + MA LQ S+ E + S + + G +
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 987 ENLQSQLKLREGEITHLQLEIGNLEKT---RSIMAEELVKLTNQNDELEEKVKEIPKLRT 1043
EN +++ E E+ L++E L+K I ++ L +L +N LE++ ++ K +
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
Query: 1044 QLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDEL 1087
QL ++R + Q K EE + + +++ KT E+
Sbjct: 833 QLEKENKR---LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873
Score = 90.9 bits (224), Expect = 6e-18
Identities = 160/804 (19%), Positives = 317/804 (39%), Gaps = 134/804 (16%)
Query: 367 SKTVESAEGKSEEVNETLVIPTEEA-----EMEESGRSATPVNCEQPDILVSSTPINEGQ 421
S + A+ K + + L TE+ E+E+ + E ++L + +
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 422 TVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDN 481
LD + E+ + +S ++ +EF ++E+ + L + K +LE+ +
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEG 369
Query: 482 LK---DEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKER---DAAKKEIKNIKEEL 535
+ D++ +++E+ + + + KK++ +E + A+K+ + L
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 536 ATRLNS-SETADLLKEKDEQIRGLMEE--GEKLSKQQLHNSNIIK--------------- 577
L S T++L + + + + E +L K ++ N ++ K
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 578 --KLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQ 635
K+ +KEN+ +L+KKV+ LE E+ KQ L + + K + +L +E
Sbjct: 490 ASKILKMEKENQ----RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL 545
Query: 636 EKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEE 695
++ R + LE++N + + S+ ++ + + KD E + L +K E
Sbjct: 546 RENSER---QIKILEQENEHLNQTV-SSLRQRSQISAEARVKDIEKENKILHESIK---E 598
Query: 696 LSAALEKAQEEARQQQETLA--IQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEA 753
S+ L K + E RQ ++ L + G+ L+ ++ + L+ +I L+ ++
Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI 658
Query: 754 ENRNQELSQSVSSTTRPLLRQIENLQATLGS---QTSSWEKLEKNLSDRLGESQTLLAAA 810
E QE S+ L R+ L+ TL S T E LEK + +L E L
Sbjct: 659 EALEQENSE--------LERENRKLKKTLDSFKNLTFQLESLEKE-NSQLDEENLELRRN 709
Query: 811 VERERAATEELLANKIQMSSMESQNSLLRQ------------------------ENSRFQ 846
VE + A+ ++ +++ +ES+ L++ EN R Q
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 847 AQLESEKNRLCKLED-------ENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMER 899
LE+ ++ +LE EN Q LE LK R LE+ KE N LE E
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR-LEQLEKE----NKSLEQET 824
Query: 900 MKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDH 959
++E+++K+ E ++ R+ + T + I ++ + LS++
Sbjct: 825 SQLEKDKKQL----EKENKRLRQQAEIKDTTLEENNVKIGNLEK---ENKTLSKE----- 872
Query: 960 SFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAE 1019
+G L+ K + + ++I L R +
Sbjct: 873 -------------------IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS 913
Query: 1020 ELVKLTNQNDELEEKVKEIPKLRTQLRDL--------DQRYNTI---LQMYGEKAEEAEE 1068
E +K N++LE+ E+ K+ L D RY + L+ +K+ E +E
Sbjct: 914 EKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKE 973
Query: 1069 LRLDLEDVKNMYKTQIDELLRQSL 1092
++ + + T ++ LRQ L
Sbjct: 974 EKIAALEARLEESTNYNQQLRQEL 997
Score = 70.1 bits (170), Expect = 1e-11
Identities = 166/884 (18%), Positives = 340/884 (38%), Gaps = 137/884 (15%)
Query: 123 QRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEETVN 182
+ E ++K E+ H+ Q+ + SQ+ S + K E N
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQRSQI-----------------SAEARVKDIEKEN 589
Query: 183 KESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSNTP 242
K + S K+S+ + + + + + + AE + L E+++E Q
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649
Query: 243 SPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASACP 302
+ + T IE L+ E+ E ++T DS +L +FQL S
Sbjct: 650 NLKI--------TCEKIEALEQENSELERENRKLKKTLDSFKNL-----TFQLESLEK-- 694
Query: 303 EYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVS----EINSDDELSGKGYALVPI 358
E ++LD+ + + ++S S+ + E+ S+ E KG L+
Sbjct: 695 ENSQLDEE--------NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 359 IVNSSTPKSKTVESAEGKSEEVNETLV-----IPTEEAEMEESGRSATPVNCEQPDILVS 413
+ + + + +++ + +TL I E+E+++ + ++ +S
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 414 STPINEGQTVLDKVAEQCEPAESQPEALS-EKEDVCKTVEFLNEKLEKREAQLLSLSKEK 472
S + + + + ++ E + L E + + + E + LE+ ++ +L KE
Sbjct: 807 SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
Query: 473 ALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIK 532
L + K+ R+KE + E +R K + ++ + K + + +
Sbjct: 867 KTLSKEIGIYKESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922
Query: 533 EELATRLNSSETADLLKEK---------DEQIRGLMEEGEKLSKQQLH-NSNIIKKLRAK 582
+L + E L KE+ D + + L + E K+ L I L A+
Sbjct: 923 NDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEAR 982
Query: 583 DKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQE----KD 638
+E+ N +L +++K +++ + LKQ D EE Q I ++ ER+ ++
Sbjct: 983 LEESTNYNQQLRQELKTVKKNYEALKQRQD--EERMVQSSPPISGEDNKWERESQETTRE 1040
Query: 639 LGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSA 698
L +++ + E+E N ++QA + +L L N + +AQ AL R+ + +E +
Sbjct: 1041 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN--NNLQAQILALQRQTVSLQEQNT 1098
Query: 699 ALEKAQEEARQQQETLAIQVGDL----------RLALQRTEQAAARKEDYLR-------- 740
L+ + + + TL Q L + +L+ ++ ++ + L+
Sbjct: 1099 TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1158
Query: 741 -HEIGELQQRLQEAENRNQELSQSVSSTTRPLL----RQIENLQATLGSQTSSWEKLEKN 795
HE EL Q +E + + L R +E+ L Q E LEK
Sbjct: 1159 DHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKM 1218
Query: 796 L---------------------------SDRLGESQTLLAAAVE---RERAATEELLAN- 824
L +DRL + + L E + + LL N
Sbjct: 1219 LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNS 1278
Query: 825 KIQMSSMESQNSLLRQENSRFQAQLESEK-NRLCKL--------EDENNRYQVELENLKD 875
K++ + +E++ S L+++ Q + S K N C+L E+EN +++ L
Sbjct: 1279 KLEQTRLEAEFSKLKEQYQ--QLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLML 1336
Query: 876 EYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEK 919
+ LE+ + K L + + K+ + R++ +E I ++
Sbjct: 1337 QNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
Score = 53.9 bits (128), Expect = 8e-07
Identities = 100/456 (21%), Positives = 187/456 (41%), Gaps = 57/456 (12%)
Query: 676 AKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARK 735
A + +E + R + AA+ +E QE V DL+ ++ T+ +
Sbjct: 132 AVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQEN----VFDLQW-MEVTDMSQEDI 186
Query: 736 EDYLRHEIGELQQRLQEAENRNQ---ELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKL 792
E L++ L++ + E + ++ ELS+ L + Q+ GS +
Sbjct: 187 EPLLKNMALHLKRLIDERDEHSETIIELSEERDGL-HFLPHASSSAQSPCGSPGMKRTES 245
Query: 793 EKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESE 852
++LS L +++ + + TE+LL K ++ ME + L+QEN + S
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 853 KN-------------RLCKLEDENNRYQVELENLKDEYVRTLEETRKE-------KTLLN 892
+ R+ KLE E +RY+ L ++ + Y +EE +++ KT+L
Sbjct: 306 RMYRDELDALREKAVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVLLETKTMLE 364
Query: 893 SQLEMERMKVEQ---------ERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDM 943
QLE R + ++ + K + E ++ +RK M+ ++M
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMT-------LEM 417
Query: 944 AGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHL 1003
A Q S DES + IS S L +A + G + E S+L E E L
Sbjct: 418 AQKQ----SMDESLHLGWELEQISRT-SELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 1004 QLEIGNLEKTRSIM---AEELVKLTNQNDELEEKVKEIP-KLRTQLRDLDQRYNTILQMY 1059
+ L T + A +++K+ +N L +KV+ + ++ + + L N +
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
Query: 1060 GEKAEEAEELRLDLEDVKNMYK--TQIDELLRQSLS 1093
EKA+ + + E+ + K Q +E L Q++S
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 114 bits (284), Expect = 7e-25
Identities = 178/788 (22%), Positives = 333/788 (42%), Gaps = 105/788 (13%)
Query: 369 TVESAEG------KSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQT 422
TV+S EG K E+ N+ L E E E + NC+ S + + +
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN-----LSKDLMKEKA 536
Query: 423 VLDKVAEQC-EPAESQPEALS-EKEDVCKTVEFLNEKLE-KREAQLLSLSKEKALLEEAF 479
L+K E E +E Q + L E E + +TV L ++ + EA++ + KE +L E+
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
Query: 480 DNLKDEMFRVKEESSSISSLKDEFTQ---RIAEAEKKVQLACKERDAAKKEIKNIKEELA 536
++ +++ E I + + + R E E ++ KE + +K+I N+K
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI--- 653
Query: 537 TRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAK---L 593
T + ++ +++ L E KL K N+ +L + +KEN + + L
Sbjct: 654 -------TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 594 NKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKN 653
+ V+ L+ + Q+ +E+E + +E +KK +++ K RL+V L+ +N
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESE-KEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 654 RSIQAALDSAYK-------ELTDLHKANAAKDSEAQEAALS--------REMKAKEELSA 698
+ +Q L+++ K EL DL N +E +S +E K+ E+ ++
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 699 ALEKAQEEARQQQETLAIQ--VGDLRLALQRTEQAAARKEDY-LRHEIGELQQ---RLQE 752
LEK +++ ++ + L Q + D L + KE+ L EIG ++ RL+E
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Query: 753 AENRNQELSQSVSSTTRPLLRQIENLQAT----------LGSQTSSWEKL---------- 792
E N+EL + + + L+ E+L + L T EK+
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
Query: 793 EKNLSDRLGESQTLLAAAVERERAATEELLAN-KIQMSSMESQNSLLRQENSRFQAQLES 851
E++ DR ++ L + +++ EE +A + ++ + N LRQE + E+
Sbjct: 946 EQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1005
Query: 852 EKNRLCKLEDENNRYQVE--LENLKDEYVRTLEETRKEKTLLNSQL-EMERMKVE-QERK 907
K R +DE Q + +++ R +ET +E + +L E+ER Q K
Sbjct: 1006 LKQR----QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
Query: 908 KAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMA-GLQTSFLSQDESHDHSFGPMPI 966
+A+ TQ E + ++ S+ + Q + L + S +S +
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
Query: 967 SANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSI---MAEELVK 1023
+ N L SS+ +S +K RE + I + EK + A E
Sbjct: 1122 NQNAQLLIQQ------SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYES 1175
Query: 1024 LTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQ 1083
L +++ L+ K L + RDL+ RYN +L+ G+ LED++ M K +
Sbjct: 1176 LISKHGTLKSAHKN---LEVEHRDLEDRYNQLLKQKGQ-----------LEDLEKMLKVE 1221
Query: 1084 IDELLRQS 1091
+++L ++
Sbjct: 1222 QEKMLLEN 1229
Score = 108 bits (270), Expect = 3e-23
Identities = 216/1013 (21%), Positives = 419/1013 (41%), Gaps = 135/1013 (13%)
Query: 130 KSSLHESLHIGQ-----SRTPETTES--------------------QVKDSSLCVSGETL 164
K S+ ESLH+G SRT E +E+ ++++ SL + E L
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 479
Query: 165 AAGTSSPKTEGKHEETVNKESDMKVPTVSLKVSES-VIDVKTTMESISNTS--------- 214
T+ EG + + E + + + +++ E+ ++ K ++++ N S
Sbjct: 480 R--TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
Query: 215 ---TQSLTAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLD---HESVI 268
T E + ++ EQ++E S + S + DIE + HES+
Sbjct: 538 LEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 269 SESSASSRQETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDAFERIDS 328
SS S+ E K + ++ A N L +K E +I
Sbjct: 598 ETSSKLSKIEF--EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC 655
Query: 329 FSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNE-TLVIP 387
+++L+ + SE+ ++ K ++S + +ES E ++ +++E L +
Sbjct: 656 EKIEALEQEN-SELERENRKLKK-------TLDSFKNLTFQLESLEKENSQLDEENLELR 707
Query: 388 TEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALS-EKED 446
++ + + E ++ + +G +L ++ E E + L E +
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQR 767
Query: 447 VCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQR 506
+ KT+E N+K+++ E++L L E L++ + LK R+++ SL+ E +Q
Sbjct: 768 LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ- 826
Query: 507 IAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLS 566
E+D KK+++ + L + +T L+E + +I L +E + LS
Sbjct: 827 ------------LEKD--KKQLEKENKRLRQQAEIKDTT--LEENNVKIGNLEKENKTLS 870
Query: 567 KQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIK 626
K+ +L+ +KEN+ +V + +K L L++ L ++ +Q +++
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVT----LREDLVSEKLKTQQMNNDLE 926
Query: 627 KLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKAN-AAKDSEAQEAA 685
KL +E+ + RL D +++ + +++ L+S K+ ++ + AA ++ +E+
Sbjct: 927 KLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEEST 986
Query: 686 -----LSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLR 740
L +E+K ++ AL++ Q+E R Q + I D + +R Q R
Sbjct: 987 NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK--WERESQETTR------ 1038
Query: 741 HEIGELQQRLQEAENRNQEL---SQSVSSTTRPLLRQIENLQA---TLGSQTSSWEKLEK 794
E+ +++ RL E E N L Q++ + + L Q NLQA L QT S ++
Sbjct: 1039 -ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNT 1097
Query: 795 NLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKN 854
L + + Q + + + + IQ SS+E++N + +E ++ +S
Sbjct: 1098 TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1157
Query: 855 RLCKLEDENNRYQVELENLKDEY-------------VRTLEETRKEKTLLNSQLE-MERM 900
KLE + R E E+L ++ R LE+ + QLE +E+M
Sbjct: 1158 DHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKM 1217
Query: 901 -KVEQERK-KAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHD 958
KVEQE+ ET+ + +K + + S + +T L D +
Sbjct: 1218 LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK-------ETEVLQTDHKNL 1270
Query: 959 HSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEI-----GNLEKT 1013
S N S L + R+ A S ++ QL + ++ + Q E+ GNLE+
Sbjct: 1271 KSL------LNNSKL-EQTRLEAEFSKLKEQYQQLDITSTKLNN-QCELLSQLKGNLEEE 1322
Query: 1014 RSIMAEELVKLTNQNDELEEKVKEIPKL-RTQLRDLDQRYNTILQMYGEKAEE 1065
+ +++ L QN L E+ E L + R + N L+ EK EE
Sbjct: 1323 NRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNE-LRRQKEKLEE 1374
Score = 102 bits (253), Expect = 3e-21
Identities = 140/644 (21%), Positives = 281/644 (43%), Gaps = 69/644 (10%)
Query: 493 SSSISSLKDEFTQRIAEAEKKVQ--LACK-ERDAAKKEIKNIKEELATRLNSSETADLLK 549
S ++ K + + E E+K + L CK E + + E+K +++E L+ + +A + +
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 550 EKDEQIRGLMEEGEKLS------KQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEE 603
++ + +R +KL K++LH+ K R ++ + +N V K + LE++
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKA-RVEELKEDNQVLLETKTM--LEDQ 366
Query: 604 LQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSA 663
L+ + D E+EK++ + KL+ M E+D+ R +++ EL E+N +++ A +
Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDM--EMERDMDRKKIE--ELMEENMTLEMAQKQS 422
Query: 664 YKE-------LTDLHKANAAKDS-------EAQEAALSREMKAKEELSAALEKAQEEARQ 709
E L + + + ++ E E SR +K + E + +L K EE R
Sbjct: 423 MDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME-NQSLTKTVEELRT 481
Query: 710 QQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTR 769
+++ + L +++ Q ++K + L +EI + +Q LQ +N +++L + + +
Sbjct: 482 TVDSVEGNASKI-LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 770 PLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAV----ERERAATEELLANK 825
+ EN + + E L + +S SQ A V + + E +
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 826 IQMSSMESQNSLLRQENSRFQ---AQLESEKNRLCKLEDENNRYQVELENLK--DEYVRT 880
++S +E + +++E ++ + E +N L LE EN Q ++ NLK E +
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 881 LEETRKEKTLLNSQLEMERMKVEQ---ERKKAIFTQETIKEKERKPFSVSSTPTMSRSSS 937
LE+ NS+LE E K+++ K F E++ EKE + S
Sbjct: 661 LEQE-------NSELERENRKLKKTLDSFKNLTFQLESL-EKENSQLDEENLELRRNVES 712
Query: 938 I--SGVDMAGLQ---TSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAG------SSII 986
+ + + MA LQ S+ E + S + + G +
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 987 ENLQSQLKLREGEITHLQLEIGNLEKT---RSIMAEELVKLTNQNDELEEKVKEIPKLRT 1043
EN +++ E E+ L++E L+K I ++ L +L +N LE++ ++ K +
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
Query: 1044 QLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDEL 1087
QL ++R + Q K EE + + +++ KT E+
Sbjct: 833 QLEKENKR---LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873
Score = 91.3 bits (225), Expect = 5e-18
Identities = 160/803 (19%), Positives = 317/803 (39%), Gaps = 133/803 (16%)
Query: 367 SKTVESAEGKSEEVNETLVIPTEEA-----EMEESGRSATPVNCEQPDILVSSTPINEGQ 421
S + A+ K + + L TE+ E+E+ + E ++L + +
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 422 TVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDN 481
LD + E+ + +S ++ +EF ++E+ + L + K +LE+ +
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEG 369
Query: 482 LK---DEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKER---DAAKKEIKNIKEEL 535
+ D++ +++E+ + + + KK++ +E + A+K+ + L
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 536 ATRLNS-SETADLLKEKDEQIRGLMEE--GEKLSKQQLHNSNIIK--------------- 577
L S T++L + + + + E +L K ++ N ++ K
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 578 --KLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQ 635
K+ +KEN+ +L+KKV+ LE E+ KQ L + + K + +L +E
Sbjct: 490 ASKILKMEKENQ----RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL 545
Query: 636 EKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEE 695
++ R + LE++N + + S+ ++ + + KD E + L +K E
Sbjct: 546 RENSER---QIKILEQENEHLNQTV-SSLRQRSQISAEARVKDIEKENKILHESIK---E 598
Query: 696 LSAALEKAQEEARQQQETLA--IQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEA 753
S+ L K + E RQ ++ L + G+ L+ ++ + L+ +I L+ ++
Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI 658
Query: 754 ENRNQELSQSVSSTTRPLLRQIENLQATLGS---QTSSWEKLEKNLSDRLGESQTLLAAA 810
E QE S+ L R+ L+ TL S T E LEK + +L E L
Sbjct: 659 EALEQENSE--------LERENRKLKKTLDSFKNLTFQLESLEKE-NSQLDEENLELRRN 709
Query: 811 VERERAATEELLANKIQMSSMESQNSLLRQ------------------------ENSRFQ 846
VE + A+ ++ +++ +ES+ L++ EN R Q
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 847 AQLESEKNRLCKLED-------ENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMER 899
LE+ ++ +LE EN Q LE LK R LE+ KE N LE E
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR-LEQLEKE----NKSLEQET 824
Query: 900 MKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDH 959
++E+++K+ E ++ R+ + T + I ++ + LS++
Sbjct: 825 SQLEKDKKQL----EKENKRLRQQAEIKDTTLEENNVKIGNLEK---ENKTLSKE----- 872
Query: 960 SFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAE 1019
+G L+ K + + ++I L R +
Sbjct: 873 -------------------IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS 913
Query: 1020 ELVKLTNQNDELEEKVKEIPKLRTQLRDL-------DQRYNTI---LQMYGEKAEEAEEL 1069
E +K N++LE+ E+ K+ L D RY + L+ +K+ E +E
Sbjct: 914 EKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEE 973
Query: 1070 RLDLEDVKNMYKTQIDELLRQSL 1092
++ + + T ++ LRQ L
Sbjct: 974 KIAALEARLEESTNYNQQLRQEL 996
Score = 71.2 bits (173), Expect = 5e-12
Identities = 166/883 (18%), Positives = 341/883 (38%), Gaps = 136/883 (15%)
Query: 123 QRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEETVN 182
+ E ++K E+ H+ Q+ + SQ+ S + K E N
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQRSQI-----------------SAEARVKDIEKEN 589
Query: 183 KESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSNTP 242
K + S K+S+ + + + + + + AE + L E+++E Q
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649
Query: 243 SPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASACP 302
+ + T IE L+ E+ E ++T DS +L +FQL S
Sbjct: 650 NLKI--------TCEKIEALEQENSELERENRKLKKTLDSFKNL-----TFQLESLEK-- 694
Query: 303 EYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVS----EINSDDELSGKGYALVPI 358
E ++LD+ + + ++S S+ + E+ S+ E KG L+
Sbjct: 695 ENSQLDEE--------NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 359 IVNSSTPKSKTVESAEGKSEEVNETLV-----IPTEEAEMEESGRSATPVNCEQPDILVS 413
+ + + + +++ + +TL I E+E+++ + ++ +S
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 414 STPINEGQTVLDKVAEQCEPAESQPEALS-EKEDVCKTVEFLNEKLEKREAQLLSLSKEK 472
S + + + + ++ E + L E + + + E + LE+ ++ +L KE
Sbjct: 807 SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
Query: 473 ALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIK 532
L + K+ R+KE + E +R K + ++ + K + + +
Sbjct: 867 KTLSKEIGIYKESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922
Query: 533 EELATRLNSSETADLLKEK--------DEQIRGLMEEGEKLSKQQLH-NSNIIKKLRAKD 583
+L + E L KE+ D++ + L + E K+ L I L A+
Sbjct: 923 NDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
Query: 584 KENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQE----KDL 639
+E+ N +L +++K +++ + LKQ D EE Q I ++ ER+ ++L
Sbjct: 983 EESTNYNQQLRQELKTVKKNYEALKQRQD--EERMVQSSPPISGEDNKWERESQETTREL 1040
Query: 640 GRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAA 699
+++ + E+E N ++QA + +L L N + +AQ AL R+ + +E +
Sbjct: 1041 LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN--NNLQAQILALQRQTVSLQEQNTT 1098
Query: 700 LEKAQEEARQQQETLAIQVGDL----------RLALQRTEQAAARKEDYLR--------- 740
L+ + + + TL Q L + +L+ ++ ++ + L+
Sbjct: 1099 LQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD 1158
Query: 741 HEIGELQQRLQEAENRNQELSQSVSSTTRPLL----RQIENLQATLGSQTSSWEKLEKNL 796
HE EL Q +E + + L R +E+ L Q E LEK L
Sbjct: 1159 HEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1218
Query: 797 ---------------------------SDRLGESQTLLAAAVE---RERAATEELLAN-K 825
+DRL + + L E + + LL N K
Sbjct: 1219 KVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSK 1278
Query: 826 IQMSSMESQNSLLRQENSRFQAQLESEK-NRLCKL--------EDENNRYQVELENLKDE 876
++ + +E++ S L+++ Q + S K N C+L E+EN +++ L +
Sbjct: 1279 LEQTRLEAEFSKLKEQYQ--QLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQ 1336
Query: 877 YVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEK 919
LE+ + K L + + K+ + R++ +E I ++
Sbjct: 1337 NRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
Score = 53.9 bits (128), Expect = 8e-07
Identities = 100/456 (21%), Positives = 187/456 (41%), Gaps = 57/456 (12%)
Query: 676 AKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARK 735
A + +E + R + AA+ +E QE V DL+ ++ T+ +
Sbjct: 132 AVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQEN----VFDLQW-MEVTDMSQEDI 186
Query: 736 EDYLRHEIGELQQRLQEAENRNQ---ELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKL 792
E L++ L++ + E + ++ ELS+ L + Q+ GS +
Sbjct: 187 EPLLKNMALHLKRLIDERDEHSETIIELSEERDGL-HFLPHASSSAQSPCGSPGMKRTES 245
Query: 793 EKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESE 852
++LS L +++ + + TE+LL K ++ ME + L+QEN + S
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 853 KN-------------RLCKLEDENNRYQVELENLKDEYVRTLEETRKE-------KTLLN 892
+ R+ KLE E +RY+ L ++ + Y +EE +++ KT+L
Sbjct: 306 RMYRDELDALREKAVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVLLETKTMLE 364
Query: 893 SQLEMERMKVEQ---------ERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDM 943
QLE R + ++ + K + E ++ +RK M+ ++M
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMT-------LEM 417
Query: 944 AGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHL 1003
A Q S DES + IS S L +A + G + E S+L E E L
Sbjct: 418 AQKQ----SMDESLHLGWELEQISRT-SELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 1004 QLEIGNLEKTRSIM---AEELVKLTNQNDELEEKVKEIP-KLRTQLRDLDQRYNTILQMY 1059
+ L T + A +++K+ +N L +KV+ + ++ + + L N +
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
Query: 1060 GEKAEEAEELRLDLEDVKNMYK--TQIDELLRQSLS 1093
EKA+ + + E+ + K Q +E L Q++S
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 111 bits (278), Expect = 3e-24
Identities = 134/672 (19%), Positives = 292/672 (43%), Gaps = 98/672 (14%)
Query: 458 LEKREAQLLSLSKEKAL-LEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQL 516
L+K Q+ +L L E + LKDE +++ + +S + + +A+ ++V +
Sbjct: 226 LKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAV 285
Query: 517 ACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEG---EKLSKQQ---- 569
+E K + + T+ N + T +LLK++ + + +EE E +SK+
Sbjct: 286 YVQELQKLKSSVNEL-----TQKNQTLTENLLKKEQDYTK--LEEKHNEESVSKKNIQAT 338
Query: 570 LHNSNI-IKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKL 628
LH ++ ++L+++ +E + +++ ++ E E Q LK+ L E + + K+L
Sbjct: 339 LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQL 398
Query: 629 NSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAK--DSEAQEAAL 686
E +E+ +LQ ++++L K + L A+ L + + ++ K D E Q A L
Sbjct: 399 QQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADL 458
Query: 687 SREMKAKEE-----------LSAALEKAQEEARQQQ-----------------ETLAIQV 718
++ EE L L+K +++ ++QQ E + Q+
Sbjct: 459 QLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518
Query: 719 GDLRLALQRTEQAAARKED---YLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQI 775
GD +Q E + ++ L E +L ++Q E L+Q + L Q+
Sbjct: 519 GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQV 577
Query: 776 ENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQN 835
L L +Q+ S ++ ++NL D++ E + L RAA + +L+ + ++ + SQ
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHL-------RAAQDRVLSLETSVNELNSQL 630
Query: 836 SLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQL 895
+ +++ S+ Q++++ L E + +L+N D L++ ++E + +QL
Sbjct: 631 NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 896 EMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDE 955
+ K++ +++ + +KE + K S+ ++ + G + L+ L
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE-----QKTEELEG-QIKKLEADSLEVKA 744
Query: 956 SHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRS 1015
S + + L D + L + L+LR E++ LE +
Sbjct: 745 SKEQA------------LQDLQQQ-------RQLNTDLELRATELSK------QLEMEKE 779
Query: 1016 IMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLED 1075
I++ + L +++ LE +++ K + + L Q + T+ ++E ++ E+
Sbjct: 780 IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL----------SQETKIQHEE 829
Query: 1076 VKNMYKTQIDEL 1087
+ N +T + EL
Sbjct: 830 LNNRIQTTVTEL 841
Score = 107 bits (267), Expect = 6e-23
Identities = 157/745 (21%), Positives = 298/745 (40%), Gaps = 129/745 (17%)
Query: 435 ESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESS 494
E++P+ L D ++ L ++LE+ + + ++ + K L E+ L E+ +K +
Sbjct: 123 EAKPDGLVT--DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD 180
Query: 495 SISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKE---- 550
SL++ AE+KV +E + I+++K EL R + A L KE
Sbjct: 181 EERSLREA-------AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQV 233
Query: 551 ----------KDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVA-------KL 593
++ + L +E +KL Q + I +LR++ + VA KL
Sbjct: 234 QTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKL 293
Query: 594 NKKVKELEEELQHLKQVLDGKEE-----VEKQHRENIKKLNSMVERQEKDLG-------- 640
V EL ++ Q L + L KE+ EK + E++ K N +KDL
Sbjct: 294 KSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRL 353
Query: 641 --------RLQVDMDELEEKNRSIQAAL---DSAYKELTDLHKANAAKDSEAQEAAL--- 686
R+ V++ E E + ++ L ++ Y+ L K + E ++ L
Sbjct: 354 SASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQ 413
Query: 687 -------SREMKAKEELSAALEKAQEEARQQQETLAI---QVGDLRLALQRTEQAAARK- 735
S+ ++ + +L A + +E+ + E L QV DL+L L R E+ K
Sbjct: 414 SEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV 473
Query: 736 --EDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPL---LRQI-------ENLQATLG 783
L+H++ + +Q+ QE + Q + + L LRQI +NL+A L
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ 533
Query: 784 SQTSSWEKLEKNLSD-----RLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLL 838
+ LEK D + GE +T + ++ + +E + + +S++
Sbjct: 534 KSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ 593
Query: 839 RQENSRFQAQ-----LESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNS 893
QEN Q Q L + ++R+ LE N +L K++ V L+ K KT L
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK-VSQLDIQIKAKTELLL 652
Query: 894 QLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQ 953
E + + + + T + + +++ + +T ++ + + SQ
Sbjct: 653 SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD------KQEHCSQ 706
Query: 954 DESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKT 1013
ESH + +S L+ + + EG+I L+ + ++ +
Sbjct: 707 LESHLKEYKEKYLS---------------------LEQKTEELEGQIKKLEADSLEVKAS 745
Query: 1014 RSIMAEELVKLTNQNDELEEKVKEIPK-----------LRTQLRDLDQRYNTILQMYGEK 1062
+ ++L + N +LE + E+ K R L+ + +I Q ++
Sbjct: 746 KEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQ 805
Query: 1063 AEEAEELRLDLEDVKNMYKTQIDEL 1087
EE + L+ D E + K Q +EL
Sbjct: 806 EEEKQILKQDFETLSQETKIQHEEL 830
Score = 105 bits (262), Expect = 2e-22
Identities = 199/1070 (18%), Positives = 441/1070 (41%), Gaps = 137/1070 (12%)
Query: 107 QTIQKSPVVSKPPAKSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAA 166
Q + +V+ A+ Q E++++ + E+ +I Q + + E + LA
Sbjct: 122 QEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMK--DLFEQKAAQ---------LAT 170
Query: 167 GTSSPKTEGKHEETVNKESDMKVPTVSLKVSES---VIDVKTTM------ESISNTSTQS 217
+ K++ E ++ + ++ KV ++ ++++ + D+KT + E ++ +
Sbjct: 171 EIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKEL 230
Query: 218 LTAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQ 277
+ +T + + ++ ++ + S ++S +T S + + + A Q
Sbjct: 231 VQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR--SELAKGPQEVAVYVQ 288
Query: 278 ETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDAFERIDSFSVQS-LDS 336
E KSS++ + Q L+ + + D+ KL E E + ++Q+ L
Sbjct: 289 ELQKLKSSVNELTQKNQTLTENLL---KKEQDYTKLEEKHNE----ESVSKKNIQATLHQ 341
Query: 337 RSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEES 396
+ + LS +L I V S T + E SE + + E ++++
Sbjct: 342 KDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ 401
Query: 397 GRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNE 456
EQ + + S IN+ + L + Q A + L E+ + +E
Sbjct: 402 REEK-----EQHGLQLQSE-INQLHSKLLETERQLGEAHGR---LKEQRQLS------SE 446
Query: 457 KLEKREAQLLSLSKEKALLEEAFDN-------LKDEMFRVKEESSSISSLKDEFTQRIAE 509
KL +E Q+ L + + LEE L+ ++ + K++ +L+ T ++ E
Sbjct: 447 KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
Query: 510 AEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQ 569
A+ ++ ++ ++I+N++ L S E LL+++ E + ++ GE
Sbjct: 507 AQNDLEQVLRQIGDKDQKIQNLEALLQ---KSKENISLLEKEREDLYAKIQAGEG----- 558
Query: 570 LHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQH-------- 621
+ ++ +L+ K+ + V +L +K+K E + ++ L + + +K H
Sbjct: 559 --ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 622 ---RENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKD 678
++ +LNS + ++ + +L + + E S +AA + +L + H A
Sbjct: 617 LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN-HLDTAQNA 675
Query: 679 SEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAAR---- 734
+ ++ L++ ++++A L+ QE Q + L Q+TE+ +
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
Query: 735 KEDYLRHEIGELQ--QRLQEAENRNQELSQSVSSTTRPLLRQIENLQAT---LGSQTSSW 789
+ D L + + Q Q LQ+ N +L + ++ L + E + +T L ++ +
Sbjct: 736 EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 790 EKLEKNLSDRLGESQTLLA--AAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQA 847
E +++ L+ + E Q L + +E E L N+IQ + E Q ++ E
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK--VKMEKEALMT 853
Query: 848 QLESEKNRLCKLED--ENNRYQVELEN----------------LKDEYVRTLEETRKEKT 889
+L + K++L K+ D +N++ + E EN LK + +E T KE+
Sbjct: 854 ELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK 913
Query: 890 LLNSQLEMER-------MKVEQERKKAIFTQETIKEKERKPFSV---------SSTPTMS 933
L LE E+ +++ +++ I Q T+K+ E++ + SS
Sbjct: 914 ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKK 973
Query: 934 RSSSISG-VDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSS-IIENLQS 991
+ ++ G + +A LQ + L + ++A + S + LQS
Sbjct: 974 QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 992 QLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQL------ 1045
RE E+ + ++ ++E+ S+ E+L+ NQ + ++E+ + L
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAK 1093
Query: 1046 --RDLDQRYNTILQMYGEKAEEAEEL------RLDLEDVKNMYKTQIDEL 1087
+ L +R + + EK+ + +EL ++E++K + +I +L
Sbjct: 1094 KEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL 1143
Score = 99.0 bits (245), Expect = 2e-20
Identities = 196/1012 (19%), Positives = 431/1012 (42%), Gaps = 147/1012 (14%)
Query: 127 EEVKSSLHESLHIGQSRTP-------ETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEE 179
+++KSS++E Q+ T + T+ + K + VS + + A + + +
Sbjct: 291 QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
Query: 180 TVNKESDMKVPTVSLKVSESVIDVKTTMESISNTST--QSLTAETKDIALEPKEQKHEDR 237
+ S+ + + +++SE + E +S T Q L AE K + +Q+ E++
Sbjct: 351 SRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQL-----QQQREEK 405
Query: 238 QSNTPSPPVSTFSSGTSTTSDIEVLDHESVISE---SSASSRQETTDSKSSLHLMQTSFQ 294
+ + G S+I L + + +E A R + SS LM Q
Sbjct: 406 EQH-----------GLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454
Query: 295 LLSASACPEYNRLDDFQKLTESCCSSDAFE-RIDSFSVQSLDSRSVSEINSDDELSGKGY 353
+ + +RL++ +L E +S + ++D Q + +++ +
Sbjct: 455 VADLQL--KLSRLEE--QLKEKVTNSTELQHQLDKTKQQHQEQQALQQ------------ 498
Query: 354 ALVPIIVNSSTPKSKTVESAEGKSEEV-----NETLVIPTEEAEMEESGRSATPVNCEQP 408
S+T K + A+ E+V ++ I EA +++S + + + E+
Sbjct: 499 --------STTAK---LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
Query: 409 DILVSSTPINEGQT-VLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLL- 466
D L + EG+T VL+++ E+ + Q L+EK N+ ++AQ
Sbjct: 548 D-LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK--------LKNQSESHKQAQENL 598
Query: 467 --SLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAA 524
+ ++KA L A D + V E +S ++ K++ +Q + + K +L A
Sbjct: 599 HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK 658
Query: 525 KKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDK 584
+ +++ L T N+ L++K +++ + + ++++ + +L + K
Sbjct: 659 TAQRADLQNHLDTAQNA------LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 585 ENENMVAKLNKKVKELEEELQHLK----QVLDGKEEVEKQHRENIKKLNSMVERQEKDLG 640
E + L +K +ELE +++ L+ +V KE+ Q + ++LN+ +E + +L
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA-LQDLQQQRQLNTDLELRATELS 771
Query: 641 RLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEE---LS 697
+ Q++M+ KE+ + + K SEA E+ + K +EE L
Sbjct: 772 K-QLEME-----------------KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK 813
Query: 698 AALEKAQEEARQQQETLAIQVGDLRLALQRTE---QAAARKEDYLRHEIGELQQRLQEAE 754
E +E + Q E L ++ LQ+ + +A + ++ ++ ++ L+ ++
Sbjct: 814 QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK 873
Query: 755 NRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERE 814
+ ++ +Q + L + + L+ L Q + K +K L L + E+E
Sbjct: 874 SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK---------EKE 924
Query: 815 RAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLK 874
+ +L N +Q +++QN+L ++N + + QL+ N L + ++ + ++E L+
Sbjct: 925 ASHQLKLELNSMQEQLIQAQNTL--KQNEKEEQQLQGNINELKQSSEQKKK---QIEALQ 979
Query: 875 DEY-VRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMS 933
E + L++T E L QL ++ E++K Q EK ++ F +
Sbjct: 980 GELKIAVLQKTELENKL-QQQLTQAAQELAAEKEKISVLQNNY-EKSQETFKQLQSDFYG 1037
Query: 934 RSSSISGV--DMAGLQTSF-LSQDE--SHDHSFGPMPI------SANGSNLYDAVR---- 978
R S + D+ ++ L+Q++ S+ + G +A + D+ +
Sbjct: 1038 RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ 1097
Query: 979 MGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEI 1038
+ ++++Q + L+E E+ + + ++ +E+ + +E+ KL N+EL+ E
Sbjct: 1098 LQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL---NEELKSHKLES 1154
Query: 1039 PKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
K T L+D Q ++Q E +A+ L+ +E K + D++ ++
Sbjct: 1155 IKEITNLKDAKQ---LLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKE 1203
Score = 90.9 bits (224), Expect = 6e-18
Identities = 130/626 (20%), Positives = 262/626 (41%), Gaps = 112/626 (17%)
Query: 443 EKEDVCKT---VEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSL 499
EKE V T ++ +E LE + +L +EK +L++ F+ L E +++ E
Sbjct: 777 EKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET-KIQHE------- 828
Query: 500 KDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQI-RGL 558
E RI ++Q E++A E+ +K++L+ +S + + EK+ Q +
Sbjct: 829 --ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
Query: 559 MEEGEKLSKQQLHNSNI-----------IKKLRAKDKENENMVAKLNKKVKELEEELQHL 607
+ + EK K+ H + +KK K+KE + +L ++ ++E+L
Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH---QLKLELNSMQEQLIQA 943
Query: 608 KQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKEL 667
+ L E+ E+Q + NI +L E+++K + LQ ++ ++
Sbjct: 944 QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL-------------------KI 984
Query: 668 TDLHKANAAKDSEAQEAALSREMKAKEELSAAL----EKAQEEARQQQETLAIQVGDLRL 723
L K + Q ++E+ A++E + L EK+QE +Q Q + +L L
Sbjct: 985 AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL-L 1043
Query: 724 ALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLG 783
A ++ ++ K + ++ NRNQ +Q+ L+++++ +ATL
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDL---------ISNRNQIGNQN------KLIQELKTAKATLE 1088
Query: 784 SQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATE-ELLANKIQMSSMESQNSLLRQEN 842
++ K E+ L +R Q +++E++ E EL+ K +++ +E +E
Sbjct: 1089 QDSA---KKEQQLQERCKALQD-----IQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
Query: 843 SRFQAQLESEK----NRLCKLEDENN---RYQVELENLKDEYVRTLEETRKEKTLLNSQL 895
++ +L+S K + L+D + ++EL+ D +E+ ++ + +L Q+
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV 1200
Query: 896 EMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDE 955
+ E E+E KK +E E K V + ++
Sbjct: 1201 KKE----EEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT---------------- 1240
Query: 956 SHDHSFGPMPISANGSNLYDAVRMGAGSS-IIENLQSQLKLREGEITHLQLEIGNLEKTR 1014
M I+A NL + S + L+ Q GEI L+ + N + R
Sbjct: 1241 --------MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDER 1292
Query: 1015 SIMAEELVKLTNQNDELEEKVKEIPK 1040
+ E +K + ++L+ KV E+ +
Sbjct: 1293 RALLERCLKGEGEIEKLQTKVLELQR 1318
Score = 75.1 bits (183), Expect = 3e-13
Identities = 137/656 (20%), Positives = 269/656 (41%), Gaps = 60/656 (9%)
Query: 110 QKSPVVSKPPAKSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTS 169
QK+ + K + EVK+S ++L Q + T+ +++ + L
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATEL------------ 770
Query: 170 SPKTEGKHEETVNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEP 229
S + E + E + D++ + +L+ + + + + I ++L+ ETK ++
Sbjct: 771 SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK---IQH 827
Query: 230 KEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSS---- 285
+E + + + T V T V D S +S+S +S+ E
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELST-VKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
Query: 286 -LHLMQTSFQLLSASACPEYNRLDDFQKLTESC-----CSSDAFERIDSFSVQSLDSRSV 339
L L +T +L N L + ++L +S S ++S Q + +++
Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946
Query: 340 SEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAE---MEES 396
+ N +E +G + + SS K K +E+ +G+ + V+ E E ++
Sbjct: 947 LKQNEKEEQQLQGN--INELKQSSEQKKKQIEALQGELK----IAVLQKTELENKLQQQL 1000
Query: 397 GRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNE 456
++A + E+ I V + Q ++ ES E L+ ++D+ K+VE E
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES--ELLATRQDL-KSVE---E 1054
Query: 457 KLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQL 516
KL + L+S + + LK ++++S+ E + + + +K+ L
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 517 ACKE------RDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQL 570
KE + A +EIK +E+ T+LN + L E ++I L + + L +Q+L
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKL-ESIKEITNLKDAKQLLIQQKL 1173
Query: 571 HNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQH--------LKQVLDGKEEVEKQHR 622
L+A ++ + L +VK+ EEEL+ L + KE K+H
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233
Query: 623 ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQ 682
EN KL + ++LG ++ + + + ++ D E+ L +A + + +
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVL-EATVQNNQDER 1292
Query: 683 EAALSREMKAKEELSAALEKAQEEARQQQETLAI--QVGDLRLALQ-RTEQAAARK 735
A L R +K + E+ K E R+ T A ++G +LQ + QA RK
Sbjct: 1293 RALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRK 1348
Score = 69.3 bits (168), Expect = 2e-11
Identities = 154/817 (18%), Positives = 302/817 (36%), Gaps = 93/817 (11%)
Query: 127 EEVKSSLHESLHIGQSRTPETTESQVKDSSLCVS----GETLAAGTSSPKT--EGKHEET 180
E+ + L+ + G+ T + Q K+ +L E L + S K E H++
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602
Query: 181 VNKESDMK-----VPTVSLKVSESVIDVKTTMESISNTSTQS-------LTAETKDIALE 228
+++ ++ V ++ V+E + + E +S Q L+AE A
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
Query: 229 PKEQKHEDRQSNTPSPPVSTFSSGTSTTSDI------------EVLDHESVISESSASSR 276
Q H D N + T+ + ++ H E S
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE 722
Query: 277 QETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDAFERIDSFSVQ-SLD 335
Q+T + + + ++ + AS + L D Q+ + ++D R S Q ++
Sbjct: 723 QKTEELEGQIKKLEADSLEVKAS---KEQALQDLQQQRQ--LNTDLELRATELSKQLEME 777
Query: 336 SRSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKS--EEVNETLVIPTEEAEM 393
VS D L K AL I K K + E K ++ ETL T+
Sbjct: 778 KEIVSSTRLD--LQKKSEALESI-------KQKLTKQEEEKQILKQDFETLSQETKIQHE 828
Query: 394 EESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEF 453
E + R T V Q + + E TV DK+++ + ++ ++ K
Sbjct: 829 ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL 888
Query: 454 LNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKK 513
EK K L + E L E+ LK + + KE S + + +++ +A+
Sbjct: 889 DLEKTCKELKHQLQVQMENTLKEQK--ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946
Query: 514 VQLACKERDAAKKEIKNIKEELATRLNSSETAD-----LLKEKDEQIRGLMEEGEKLSKQ 568
++ KE + I +K+ + E + +K E L ++ + +++
Sbjct: 947 LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQE 1006
Query: 569 QLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKL 628
I L+ ++++ +L E EL +Q L EE +E++
Sbjct: 1007 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066
Query: 629 NSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKD----SEAQEA 684
+ + Q K + L+ LE+ + + L K L D+ K + K+ +E +
Sbjct: 1067 RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL 1126
Query: 685 ALSREMKAKEELSAA-------------------LEKAQEEARQQQETLAIQVGDLRLAL 725
A E+K ++E L+ A++ QQ+ L + L+ A+
Sbjct: 1127 AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV 1186
Query: 726 QRTEQAAARKEDYLRHEIGELQQRLQEAENR-NQELSQSVSSTTR------PLLRQIENL 778
++ ++ +D ++ E EL++ E E + + E+ + + L QI L
Sbjct: 1187 EQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITAL 1246
Query: 779 QATLGSQTSSWEKLEKNLS------DRLGESQTLLAAAVERERAATEELLANKIQMSSME 832
LG+ W+ ++ +S D L +L A V+ + LL ++ E
Sbjct: 1247 NENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLK---GE 1303
Query: 833 SQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVE 869
+ L+ + Q +L++ + +L EN Q++
Sbjct: 1304 GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
Score = 36.2 bits (82), Expect = 0.17
Identities = 60/271 (22%), Positives = 116/271 (42%), Gaps = 31/271 (11%)
Query: 836 SLLRQENSRFQAQLESEKNRLCKLEDENNRYQ-VELENLKDEYVRTLEETRKEKTLLNSQ 894
+LLRQE QA L+ EK +L+ E +YQ ++ + K + + T ++ E L Q
Sbjct: 86 TLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVT--DSSAELQSLEQQ 143
Query: 895 LE--------MERMKVEQERKKAIFTQETI-------KEKERKPFSVSSTPTMSRSSSIS 939
LE +++MK E+K A E +E+ + + ++ +
Sbjct: 144 LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
Query: 940 GVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGE 999
+ L+T L + D ++ L V+ + +E + KL++ E
Sbjct: 204 ATVIQDLKTELLQRPGIED-------VAVLKKELVQ-VQTLMDNMTLERERESEKLKD-E 254
Query: 1000 ITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMY 1059
LQ + + E T S + EL K E+ V+E+ KL++ + +L Q+ T+ +
Sbjct: 255 CKKLQSQYASSEATISQLRSELAK---GPQEVAVYVQELQKLKSSVNELTQKNQTLTENL 311
Query: 1060 GEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+K ++ +L + + +++ K I L Q
Sbjct: 312 LKKEQDYTKLE-EKHNEESVSKKNIQATLHQ 341
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 111 bits (278), Expect = 3e-24
Identities = 159/702 (22%), Positives = 294/702 (41%), Gaps = 77/702 (10%)
Query: 439 EALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISS 498
+A EK+ V+ L E++ + + L+KEK L+EA ++ ++ S+++
Sbjct: 1012 KAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTK 1071
Query: 499 LKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGL 558
K Q++ + E ++ K R ++ + ++ +L +L AD ++K +
Sbjct: 1072 AKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL--KLTQESVADAAQDKQQL---- 1125
Query: 559 MEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLD----GK 614
EKL K+ S + LR +D+ + + A++ KK+KEL+ + L++ L+ +
Sbjct: 1126 ---EEKLKKKDSELSQL--SLRVEDE--QLLGAQMQKKIKELQARAEELEEELEAERAAR 1178
Query: 615 EEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKAN 674
VEKQ E ++L + ER E + G E K + L +E H+A
Sbjct: 1179 ARVEKQRAEAARELEELSERLE-EAGGASAGQREGCRKREAELGRLRRELEEAALRHEAT 1237
Query: 675 AA--KDSEAQEAA-LSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQA 731
A + +A+ AA L ++ + + + LEK + E R + + LA V L A E+
Sbjct: 1238 VAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKL 1297
Query: 732 AARKEDYL---RHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGS---- 784
ED L + ++ ELQ++L +A + L Q+ S LL + E L + L
Sbjct: 1298 CRTYEDQLSEAKIKVEELQRQLADASTQRGRL-QTESGELSRLLEEKECLISQLSRGKAL 1356
Query: 785 QTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSR 844
S E+L + L + ++++ LA AV+ R + L + + +++ L + +
Sbjct: 1357 AAQSLEELRRQLEEE-SKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANA 1415
Query: 845 FQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRK------------EKTLLN 892
AQ S K E + + ELE K + L+E + EK L
Sbjct: 1416 EVAQWRS------KYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLR 1469
Query: 893 SQLEMERMKVEQER---------KKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDM 943
Q E E + +E ER KK + ++E+ R+ M R + +
Sbjct: 1470 LQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQ------EEEMQRELEAAQRES 1523
Query: 944 AGLQTSFLSQDESHDHSFGPM-PISANGSNLYDAV-----RMGAGSSIIENLQSQLKLRE 997
GL T H+ + + + NL + + ++ I+ L+ K E
Sbjct: 1524 RGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALE 1583
Query: 998 GEITHLQLEIG------NLEKTRSIMAE-ELVKLTNQND-ELEEKVKEIPKLRTQLRDLD 1049
GE + +Q + LE+T+++ + EL ++ + D +L EK +E LR +
Sbjct: 1584 GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAV 1643
Query: 1050 QRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQS 1091
+ L EA L+ +E N + Q+ RQ+
Sbjct: 1644 ESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQA 1685
Score = 84.3 bits (207), Expect = 6e-16
Identities = 106/512 (20%), Positives = 225/512 (43%), Gaps = 39/512 (7%)
Query: 434 AESQPEALSE-KEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEE 492
A + E L E K+ + ++ E +E A+ SL K K L+ +++ E+ R
Sbjct: 1428 AIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSA 1487
Query: 493 SSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEEL-ATRLNSSETADLLKEK 551
++++ + + + E ++ + +E +AA++E + + EL R E + L+
Sbjct: 1488 AAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETL 1547
Query: 552 DEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELE-----EELQH 606
+ + L EE L+ Q + I++L K E +++ ++E E EE +
Sbjct: 1548 KRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKT 1607
Query: 607 LKQVLD---GKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMD-ELEEKNRSIQAALDS 662
L+ L+ K EV+++ E ++ ++ ++ + LQ +D E +N +++
Sbjct: 1608 LRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLK-KK 1666
Query: 663 AYKELTDL-----HKANAAKDSEA----QEAALSREMKAKEE---LSAALEKAQEEARQQ 710
+L DL H A +++A +A L E ++E L+A L + + ++
Sbjct: 1667 MEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERR 1726
Query: 711 QETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRP 770
LA ++ +LR AL++ E++ E E+ E +RL ++N L
Sbjct: 1727 ASLLAAELEELRAALEQGERSRRLAEQ----ELLEATERLNLLHSQNTGLLNQKKKLEAD 1782
Query: 771 LLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSS 830
L + ++ + + EK +K ++D ++ L E++ +A E + ++ +
Sbjct: 1783 LAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKK---EQDTSAHLERMKKTLEQTV 1839
Query: 831 MESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTL 890
E Q L E QA L K ++ KLE + + EL+ + ++ L+ RK +
Sbjct: 1840 RELQARLEEAE----QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHE-- 1893
Query: 891 LNSQLEMERMKVEQERKKAIFTQETIKEKERK 922
+++ + E++RK Q+ + + + K
Sbjct: 1894 --RRVKELAYQAEEDRKNLARMQDLVDKLQSK 1923
Score = 84.0 bits (206), Expect = 7e-16
Identities = 141/679 (20%), Positives = 276/679 (40%), Gaps = 115/679 (16%)
Query: 456 EKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKV- 514
+ LE+ QL SK K+ L A L+ + ++E+ + + E + +++A +V
Sbjct: 1359 QSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVA 1418
Query: 515 QLACK-ERDAAKK--EIKNIKEELATRL--------------NSSETADL-LKEKDEQIR 556
Q K E DA ++ E++ K++LA RL +S E A L L+ + E +
Sbjct: 1419 QWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1478
Query: 557 GLMEEGEK----LSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLK---- 608
+E L K+Q H +++ R +++E + + ++ + L EL L+
Sbjct: 1479 LELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHE 1538
Query: 609 QVLDGKEEVEKQHR---ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYK 665
+ L+ E ++++++ E I L V K + L+ LE + IQAAL+ A
Sbjct: 1539 EALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG 1598
Query: 666 --ELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQ-QETLAIQVGDLR 722
EL + + +A + R++ K+E A L + + A + Q +L +
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARN 1658
Query: 723 LALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATL 782
AL+ ++ D L ++G ++ EA+ + L Q+ + + + L A L
Sbjct: 1659 EALRLKKKMEGDLND-LELQLGHATRQATEAQAATR-LMQAQLKEEQAGRDEEQRLAAEL 1716
Query: 783 GSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQEN 842
Q + E+ L+ L E + L R A +ELL +++ + SQN+ L +
Sbjct: 1717 HEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQK 1776
Query: 843 SRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKV 902
+ +A L + + E + + + + EE +KE+ ++ +ERMK
Sbjct: 1777 KKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ---DTSAHLERMKK 1833
Query: 903 EQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFG 962
E +T++E + + + + A L+
Sbjct: 1834 TLE--------QTVRELQAR---------------LEEAEQAALR--------------- 1855
Query: 963 PMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEI-----THLQLEIGNLEKTRSI- 1016
G ++ L+++++ E E+ H + G + R +
Sbjct: 1856 ------------------GGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVK 1897
Query: 1017 ----MAEE----LVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEE 1068
AEE L ++ + D+L+ KVK + Q + +Q+ NT L Y + E +
Sbjct: 1898 ELAYQAEEDRKNLARMQDLVDKLQSKVK---SYKRQFEEAEQQANTNLAKYRKAQHELD- 1953
Query: 1069 LRLDLEDVKNMYKTQIDEL 1087
D E+ +M +TQ ++L
Sbjct: 1954 ---DAEERADMAETQANKL 1969
Score = 73.2 bits (178), Expect = 1e-12
Identities = 131/639 (20%), Positives = 268/639 (41%), Gaps = 75/639 (11%)
Query: 454 LNEKLEKREAQLLSLSKEKA---LLEEAFDNL---KDEMFRVKEESSSISSLKDEFTQRI 507
L E ++R A++L+L + ++ L+ + L +D +F ++ + +++K+ ++
Sbjct: 822 LEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKL 881
Query: 508 AEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIR-GLMEEGEKLS 566
K + + + A++E+ ++ EL + A+ +++ E+ + +E L+
Sbjct: 882 FFKMKPLLRSAQ----AEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLA 937
Query: 567 KQ-QLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENI 625
Q Q N+ + E L K +LE +++ L + L+ +EEV
Sbjct: 938 LQLQAEQDNLA--------DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARR 989
Query: 626 KKLNSMVERQEKDLGRLQVDMDELEEKNRSIQ----------AALDSAYKELTDLHKANA 675
+KL +KD+ L++ + + E++ ++ + AALD + LT KA
Sbjct: 990 RKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKAL- 1048
Query: 676 AKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARK 735
EA + AL +++A+E+ +AL KA+ QQ E L + + TE+A +
Sbjct: 1049 ---QEAHQQALG-DLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKL 1104
Query: 736 EDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKN 795
E L+ + Q+ + ++L + S ++ LR +E+ Q LG+Q ++K
Sbjct: 1105 EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLR-VEDEQ-LLGAQ------MQKK 1156
Query: 796 LSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNR 855
+ + L A A E E EEL A + + +E Q + +E +LE
Sbjct: 1157 IKE-------LQARAEELE----EELEAERAARARVEKQRAEAARELEELSERLEEAGGA 1205
Query: 856 LCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQET 915
+ + + EL L+ R LEE + L ++ + E + + + +
Sbjct: 1206 SAGQREGCRKREAELGRLR----RELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQR 1261
Query: 916 IKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYD 975
+++K K S ++++ + A L + S + + L D
Sbjct: 1262 VRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLAD 1321
Query: 976 AVRMGAGSSIIENLQSQLKLREGEITHLQLE----IGNLEKTRSIMAEELVKLTNQNDEL 1031
A + +L+ GE++ L E I L + +++ A+ L +L Q L
Sbjct: 1322 A----------STQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQ---L 1368
Query: 1032 EEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELR 1070
EE+ K L ++ L + + + + E+AE EL+
Sbjct: 1369 EEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQ 1407
Score = 72.0 bits (175), Expect = 3e-12
Identities = 126/656 (19%), Positives = 258/656 (39%), Gaps = 76/656 (11%)
Query: 176 KHEETVNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHE 235
+HEE +++++ + K + V ++ E+ + T+ L K +AL +E +
Sbjct: 1395 QHEEEAEAQAELQ--RLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEG 1452
Query: 236 DRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSA-SSRQETTDSKSSLHLMQTSFQ 294
+N + T S+ L+ E S ++A +Q + Q
Sbjct: 1453 VEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEM 1512
Query: 295 LLSASACPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLD-SRSVSEINSDDELSGKGY 353
A +R + +A E +++ ++ + +S++ LSGK
Sbjct: 1513 QRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGK-- 1570
Query: 354 ALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVS 413
S KT ++ EG+ E+ L EEAE + E+ L
Sbjct: 1571 --------SIQELEKTKKALEGEKSEIQAAL----EEAE--------GALELEETKTLRI 1610
Query: 414 STPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKA 473
+++ + +D+ + AE E + + + + VE L L+ + K
Sbjct: 1611 QLELSQVKAEVDR-----KLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKK 1665
Query: 474 LLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKE 533
+E ++L+ ++ +++ + A + +Q KE A + E + +
Sbjct: 1666 KMEGDLNDLELQLGHATRQATEAQA-----------ATRLMQAQLKEEQAGRDEEQRLAA 1714
Query: 534 ELATRLNSSET-ADLLKEKDEQIRGLMEEGEK---LSKQQLHNSNIIKKLRAKDKENENM 589
EL + + E A LL + E++R +E+GE+ L++Q+L + ++L +N +
Sbjct: 1715 ELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEAT--ERLNLLHSQNTGL 1772
Query: 590 VAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDEL 649
LN+K K+LE +L L ++ + ++ E KK + ++L + Q L
Sbjct: 1773 ---LNQK-KKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHL 1828
Query: 650 EEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQ 709
E ++ L+ +EL A+ EA++AAL K ++L A + + + E
Sbjct: 1829 ERMKKT----LEQTVRELQ-------ARLEEAEQAALRGGKKQVQKLEAKVRELEAELDA 1877
Query: 710 QQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTR 769
+Q+ A + +R +R ++ A + E+ ++ R Q+L + S +
Sbjct: 1878 EQKKHAEALKGVRKHERRVKELAYQAEEDRKNLA------------RMQDLVDKLQSKVK 1925
Query: 770 PLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANK 825
RQ E + + + + K + L D E + + RA T + L K
Sbjct: 1926 SYKRQFEEAEQQANTNLAKYRKAQHELDD-AEERADMAETQANKLRARTRDALGPK 1980
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 110 bits (275), Expect = 7e-24
Identities = 172/845 (20%), Positives = 348/845 (41%), Gaps = 106/845 (12%)
Query: 183 KESDMKVPTVSLKVSESVIDVKTTMESISNTST--QSLTAETKDIALEPKEQKHEDRQSN 240
K S K +SE + +KT +E +T+ Q L + + E K+ E+ +++
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190
Query: 241 TPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASA 300
T+ E L+ + ++Q L Q + A +
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 301 CPEYNRLD-DFQKLTESCCSSDAF--ERIDSFSVQSLDSRSVSEINSDDELSGKGYALVP 357
+ +LD Q+L D E + S + +VS + + E G +A
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK-- 1308
Query: 358 IIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVS-STP 416
++++ +S+ ++ E EE + L + + ++EE S E+ + +
Sbjct: 1309 ---DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ 1365
Query: 417 INEGQTVLDKVAEQCEPAESQPEALSE-KEDVCKTVEFLNEKLEKREAQLLSLSKEKALL 475
+ Q+ L ++ + E+L E K+ + K E L+++LE++ L K K L
Sbjct: 1366 VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRL 1425
Query: 476 EEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEEL 535
++ D+L ++ ++ +S++ + +F Q +AE + +ERD A+ E + KE
Sbjct: 1426 QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE-KETK 1484
Query: 536 ATRLNSS--ETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKL 593
A L + E + +E + Q + L + E L + + +L + E V ++
Sbjct: 1485 ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEM 1544
Query: 594 NKKVKELEEELQHLK----------QVLDGKEEVEKQHRE------------NIKKLNSM 631
+++ELE+ELQ + Q + + E + Q R+ +++L +
Sbjct: 1545 RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Query: 632 VERQEKDLG-------RLQVDMDELEEKNRSIQAALDSAYKEL-----------TDLHKA 673
+E + K ++++D+ +LE + + A D K+L +L +A
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664
Query: 674 NAAKD--------SEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLAL 725
A++D SE + +L E+ +E A+ E+A+ A Q+++ LA ++ +
Sbjct: 1665 RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASG- 1723
Query: 726 QRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQ 785
+ A ++ L I +L++ L+E ++ + L+ TT Q++ L A L ++
Sbjct: 1724 ---KSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT----LQVDTLNAELAAE 1776
Query: 786 TSSWEK-------LEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQ---- 834
S+ +K LE+ + + Q L A + +A L A Q+ Q
Sbjct: 1777 RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836
Query: 835 ----NSLLRQENSRFQ---AQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKE 887
N L+R+ + + Q+E E+ + +++ + ++ LK R LEE +E
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK----RQLEEAEEE 1892
Query: 888 KTLLNSQLEMERMKVEQERKKAIFTQE-------TIKEKERK--PFSVSSTPTMSRSSSI 938
T N+ R K+++E A E T+K + R+ P S SS+ + R +
Sbjct: 1893 ATRANA----SRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHL 1948
Query: 939 SGVDM 943
G +
Sbjct: 1949 EGASL 1953
Score = 110 bits (274), Expect = 9e-24
Identities = 178/801 (22%), Positives = 323/801 (40%), Gaps = 131/801 (16%)
Query: 366 KSKTVESAEGKSEEVNETLV--IPTEEAEMEESGRSATPVNCEQPD----ILVSSTPINE 419
K+K + K E + L + EE +E ++ ++ E D I I+E
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080
Query: 420 GQTVLDKVAEQCEPAESQPE--------ALSEKEDVCKTVEFLNEKLEKREAQLLSLSKE 471
+ L K E+ + A ++ + AL ++ + L E E +A K+
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 472 KALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNI 531
K L E + LK E+ + +++ L+ + Q +AE +K ++ K +A +I+++
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA---QIQDM 1197
Query: 532 KEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVA 591
++ AT L L E+ EQ + EK +KQ L N K+L + K + + A
Sbjct: 1198 RQRHATALEE------LSEQLEQAKRFKANLEK-NKQGLETDN--KELACEVKVLQQVKA 1248
Query: 592 KLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEE 651
+ K K+L+ ++Q L + + + + E KL + +L + ++E E+
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKL-------QNELDNVSTLLEEAEK 1301
Query: 652 KNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQ 711
K I+ A D+A E ++ Q+ LS ++ EE +L++ QEE + +
Sbjct: 1302 K--GIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR 1359
Query: 712 ETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQR----LQEAENRNQELSQ----- 762
+ L QV LALQ +K D I L++ L++AE +Q L +
Sbjct: 1360 KNLEKQV----LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415
Query: 763 -SVSSTTRPLLRQIENLQATLGSQ---TSSWEKLEKNLSDRLGESQTLLAA-AVERERA- 816
+ T L +++++L L Q S+ EK +K L E +++ A A ER+RA
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 817 ---------------ATEELLANKIQ---------------MSS----------MESQNS 836
A EE L K + MSS +E
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 837 LLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTL----EETRKEKTLLN 892
L Q+ + QLE ++ L ED R +V ++ +K ++ R L E+ ++K LL
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 893 SQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLS 952
Q+ ++E ERK+ + K+ E +D+ L+ +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKME--------------------IDLKDLEAQIEA 1635
Query: 953 QDESHDHSFGPM-PISANGSNL---YDAVRMGAGSSIIENLQSQLKLR--EGEITHLQLE 1006
+++ D + + A + + R ++ +S+ KL+ E EI LQ E
Sbjct: 1636 ANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE 1695
Query: 1007 IGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEA 1066
+ + E+ R +E DEL +++ ++ L D +R + E+ EE
Sbjct: 1696 LASSERARRHAEQE-------RDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748
Query: 1067 EELRLDLEDVKNMYKTQIDEL 1087
+ L D Q+D L
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTL 1769
Score = 110 bits (274), Expect = 9e-24
Identities = 144/641 (22%), Positives = 282/641 (43%), Gaps = 75/641 (11%)
Query: 458 LEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLA 517
LE+ E + + +K+ A LE L+D ++EE+ +L Q + E + +Q
Sbjct: 1296 LEEAEKKGIKFAKDAASLES---QLQDTQELLQEETRQKLNLSSRIRQ-LEEEKNSLQEQ 1351
Query: 518 CKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNII- 576
+E + A+K ++ K+ LA + S+ AD K+ D+ + G +E E+ K+ L ++ +
Sbjct: 1352 QEEEEEARKNLE--KQVLALQ---SQLADTKKKVDDDL-GTIESLEEAKKKLLKDAEALS 1405
Query: 577 ----KKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMV 632
+K A DK E +L +++ +L +L H +QV E+ +K+ + + + S+
Sbjct: 1406 QRLEEKALAYDKL-EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS 1464
Query: 633 ERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKA 692
R ++ R + + E E K S+ AL+ A + + + N ++ ++ S++
Sbjct: 1465 ARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524
Query: 693 KEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQE 752
K LEK++ QQ E + Q+ +L LQ TE A R E ++ + ++ LQ
Sbjct: 1525 KNVHE--LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582
Query: 753 AENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVE 812
+ +N+E + + R L ++E+ + +S +K+E +L D L A +E
Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKD--------LEAQIE 1634
Query: 813 RERAATEELL--ANKIQMSSMESQNSLLRQENSRFQ--AQLESEKNRLCKLEDENNRYQV 868
A +E++ K+Q + Q L SR + AQ + + +L LE E + Q
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694
Query: 869 EL----------ENLKDEYVRTLEETRKEKTLL---NSQLEMERMKVEQERKKAIFTQET 915
EL E +DE + + K+ L +LE ++E+E ++ E
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754
Query: 916 IKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYD 975
+ ++ RK + T++ ++A +++ D + + L
Sbjct: 1755 LNDRFRK--TTLQVDTLN-------AELAAERSAAQKSDNARQQ------LERQNKEL-- 1797
Query: 976 AVRMGAGSSIIENLQSQLKLR-EGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEK 1034
+ ++ L+ +K + + I+ L+ +IG LE+ A+E E+K
Sbjct: 1798 -------KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 1035 VKEI-PKLRTQLRDLDQ------RYNTILQMYGEKAEEAEE 1068
+KEI ++ + R DQ + N ++ + EEAEE
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEE 1891
Score = 106 bits (264), Expect = 1e-22
Identities = 137/679 (20%), Positives = 284/679 (41%), Gaps = 86/679 (12%)
Query: 426 KVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLS----LSKEKALLEEAFDN 481
+V Q E +++ E L + ++ VE E++E++ QLL L+++ E F
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 482 LKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNS 541
++ R+ + + + + R+ E E++ Q+ E+ + I++++E+L +
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 542 SETADL--------LKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKL 593
+ L +K+ +E+I L ++ K K++ + I + ++ E E L
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 594 NKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELE--- 650
K + E + L++ L +E+ ++ + +KL+ + + LQ +DEL+
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL 1085
Query: 651 -EKNRSIQAALDSAYKELTDLHKANAAK---DSEAQEAALSREMKAKEELSAALEKAQEE 706
+K +Q AL E LHK NA K + +AQ A L + ++++ EK + +
Sbjct: 1086 AKKEEELQGALARGDDE--TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 707 ARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEA----ENRNQELSQ 762
++ E L ++ D ++ ++E E+ EL++ L+E E + Q++ Q
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKRE----QEVAELKKALEEETKNHEAQIQDMRQ 1199
Query: 763 SVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELL 822
++ L Q+E + + + + LE + + E + L E E ++L
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH-KRKKLD 1258
Query: 823 ANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVE-------LENLKD 875
A ++ + S+ LR E + ++L++E + + L +E + ++ LE+
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318
Query: 876 EYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRS 935
+ L+E ++K L+S R++ +E K ++ Q+ +E+ RK
Sbjct: 1319 DTQELLQEETRQKLNLSS-----RIRQLEEEKNSLQEQQEEEEEARKNLE---------- 1363
Query: 936 SSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLK- 994
+ LQ+ + D G IE+L+ K
Sbjct: 1364 -----KQVLALQSQLADTKKKVDDDLG----------------------TIESLEEAKKK 1396
Query: 995 -LREGEITHLQLE-----IGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDL 1048
L++ E +LE LEKT++ + +EL LT D + + K + + L
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 1049 DQRYNTILQMYGEKAEEAE 1067
+I Y E+ + AE
Sbjct: 1457 LAEEKSISARYAEERDRAE 1475
Score = 106 bits (264), Expect = 1e-22
Identities = 156/746 (20%), Positives = 333/746 (44%), Gaps = 124/746 (16%)
Query: 421 QTVLDKVAEQCEPAESQPEALS-EKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAF 479
Q + + EQ + E + L EK ++ + E++ E Q KEK L+E+
Sbjct: 949 QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008
Query: 480 DNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKK-------EIKNIK 532
++ +E++ +++ ++++ I++ E++++ K R +K E +++
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 533 EELA-TRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLR---------AK 582
+++A + E L +K+E+++G + G+ + LH +N +K +R +
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGD---DETLHKNNALKVVRELQAQIAELQE 1125
Query: 583 DKENENMVA-KLNKKVKELEEELQHLKQVLD-------GKEEVEKQHRENIKKLNSMVER 634
D E+E K K+ ++L EEL+ LK L+ ++E+ + + + +L +E
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 635 QEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEA---ALSREMK 691
+ K+ + + ++ +++ + L S E KAN K+ + E L+ E+K
Sbjct: 1186 ETKN---HEAQIQDMRQRHATALEEL-SEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 692 AKEELSAALEKAQEEARQQQETLAIQV--GDLRLALQRTEQAAARKEDYLRHEIGELQQR 749
+++ A E +++ Q + L +V GD RL ++ E+A+ L++E+ +
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEGD-RLRVELAEKASK-----LQNELDNVSTL 1295
Query: 750 LQEAENRNQELSQSVSSTTRPL--------------------LRQIENLQATLGSQTSSW 789
L+EAE + + ++ +S L +RQ+E + +L Q
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 790 EKLEKNLSDRLGESQTLLAAAVERERAATEELLANKI-QMSSMESQNSLLRQENSRFQAQ 848
E+ KNL E Q L A++ + A T++ + + + + S+E L ++ +
Sbjct: 1356 EEARKNL-----EKQVL---ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407
Query: 849 LESEKNRLCKLEDENNRYQVELENL------KDEYVRTLEETRKEKTLLNSQLEMERMKV 902
LE + KLE NR Q EL++L + + LE+ +K+ L ++ + +
Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1467
Query: 903 EQERKKAIFTQETIKEKERKPFSVS--------STPTMSRSSSISGVDMAGLQTSFLSQD 954
+ER +A + +EKE K S++ + R + DM L + S+D
Sbjct: 1468 AEERDRA---EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS---SKD 1521
Query: 955 ESHDHSFGPMPISANGSNLYDAVR-MGAGSSIIENLQSQLKLREGEI-----THLQLEIG 1008
+ G N+++ + A +E +++QL+ E E+ L+LE+
Sbjct: 1522 DV-------------GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV- 1567
Query: 1009 NLEKTRSIMAEELVKLTNQNDELEE-KVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAE 1067
N++ ++ +L QN+E + +K++ +L +L D+R L + +K
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE--DERKQRALAVASKK----- 1620
Query: 1068 ELRLDLEDVKNMYKT---QIDELLRQ 1090
++ +DL+D++ + DE+++Q
Sbjct: 1621 KMEIDLKDLEAQIEAANKARDEVIKQ 1646
Score = 92.0 bits (227), Expect = 3e-18
Identities = 137/605 (22%), Positives = 255/605 (42%), Gaps = 101/605 (16%)
Query: 548 LKEKDEQIRGLMEEGEKLSKQQLHNSNII-KKLRAKDK---ENENMVAKLNKKVKELEEE 603
+KEK ++ G +EE E+ +Q L NI+ ++L+A+ + E E M A+L K +ELEE
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI 923
Query: 604 LQHLKQVLDGKEE-------VEKQHRENIKKLNSMVERQEKDLGRLQVD----------M 646
L L+ ++ +EE +K+ + +I+ L ++ +E +LQ++ M
Sbjct: 924 LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKM 983
Query: 647 DE----LEEKN------------RSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREM 690
+E LE++N R + + A +E + A E + L +
Sbjct: 984 EEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL 1043
Query: 691 KAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRL 750
K +E+ LEKA+ + + L Q+ +L+ + + A+KE+ L+ G L +
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQ---GALARGD 1100
Query: 751 QEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEK---NLSDRLGESQTLL 807
E ++N L R L QI LQ S+ +S K EK +LS+ L +T L
Sbjct: 1101 DETLHKNNAL-----KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL 1155
Query: 808 ------------------AAAVERERAATEELLANKIQMSSMESQNSLLRQENS------ 843
E ++A EE ++ Q+ M +++ +E S
Sbjct: 1156 EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQA 1215
Query: 844 -RFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKV 902
RF+A LE K LE +N E++ L + V+ E +++K L++Q++ KV
Sbjct: 1216 KRFKANLEKNKQ---GLETDNKELACEVKVL--QQVKAESEHKRKK--LDAQVQELHAKV 1268
Query: 903 EQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFG 962
+ + + E + + + +VS T+ + G+ A S SQ
Sbjct: 1269 SEGDRLRVELAEKASKLQNELDNVS---TLLEEAEKKGIKFAKDAASLESQ--------- 1316
Query: 963 PMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELV 1022
+ L + R NL S+++ E E LQ + E+ R + ++++
Sbjct: 1317 ---LQDTQELLQEETRQKL------NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 1023 KLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKT 1082
L +Q + ++KV + L + ++ + ++ EE LE KN +
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 1083 QIDEL 1087
++D+L
Sbjct: 1428 ELDDL 1432
Score = 45.4 bits (106), Expect = 3e-04
Identities = 56/256 (21%), Positives = 109/256 (42%), Gaps = 27/256 (10%)
Query: 843 SRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEME-RMK 901
+R + +L+++ L K++++ + + ELE ++ ++ + LE EK +L QL+ E +
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLE----EKNILAEQLQAETELF 903
Query: 902 VEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSF 961
E E +A + + +E S + I + +Q +E D
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 962 GPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEEL 1021
G A + V ++++K E EI L+ + K + +M + +
Sbjct: 964 G-----ARQKLQLEKV----------TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008
Query: 1022 VKLTNQNDELEEKVKEIPKLRTQ----LRDLDQRYNTILQMYGEKAEEAEEL---RLDLE 1074
+ ++Q E EEK K + K+R + + DL++R + E + +L DL+
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 1075 DVKNMYKTQIDELLRQ 1090
D + QIDEL Q
Sbjct: 1069 DQIAELQAQIDELKLQ 1084
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 110 bits (275), Expect = 7e-24
Identities = 156/750 (20%), Positives = 300/750 (40%), Gaps = 129/750 (17%)
Query: 368 KTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKV 427
+++ E +++ E L ++ E E S A ++ EQ L I E Q ++++
Sbjct: 1068 ESIMDLENDKQQIEEKL----KKKEFELSQLQAK-IDDEQVHSLQFQKKIKELQARIEEL 1122
Query: 428 AEQCEPAESQPEALSEKE--DVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDE 485
E+ E AE A EK+ D+ + +E ++E+LE+ + + E F ++ +
Sbjct: 1123 EEEIE-AEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRD 1181
Query: 486 MFRVK-EESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSET 544
+ + ++ ++L+ + +AE +++ + + +KE +K E+ ++ E
Sbjct: 1182 LEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEA 1241
Query: 545 ADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEEL 604
K E+ +E+ +++AKD++ ++ LN + L+ +
Sbjct: 1242 LSKSKSNIERTCRTVEDQ-------------FSEIKAKDEQQTQLIHDLNMQKARLQTQN 1288
Query: 605 QHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAY 664
L ++ KE + Q ++ + L +E ++ + +E + KN A S +
Sbjct: 1289 GELSHRVEEKESLISQLTKSKQALTQQLEELKRQME------EETKAKNAMAHALQSSRH 1342
Query: 665 KELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLA 724
D + E +AK EL AL KA E Q + A
Sbjct: 1343 -------------DCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD------A 1383
Query: 725 LQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQ---SVSSTTRPLLRQIENLQ-- 779
+QRTE+ K+ +L QRLQEAE + + S+ T + L ++E+L
Sbjct: 1384 IQRTEELEEAKK--------KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRD 1435
Query: 780 --------ATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSM 831
ATL + +++K+ +L ESQ L AA + R+ + EL + +
Sbjct: 1436 LERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV 1495
Query: 832 ESQNSLLRQENSRFQAQLESEKNRLCKL-----EDENNRYQVELENLKDEYVRTLEETR- 885
Q LR+EN Q ++ ++ + E E + VE E K + LEE
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQE--KSDLQVALEEVEG 1553
Query: 886 ----KEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGV 941
+E +L QLE+ ++K E +RK I E I++ +R +
Sbjct: 1554 SLEHEESKILRVQLELSQVKSELDRK-VIEKDEEIEQLKRNSQRAAEA------------ 1600
Query: 942 DMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEIT 1001
LQ+ ++ S + DA+R+ K EG++
Sbjct: 1601 ----LQSVLDAEIRSRN----------------DALRLK-------------KKMEGDLN 1627
Query: 1002 HLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGE 1061
+++++G+ + MAE L +L++ + DL ++ + + G
Sbjct: 1628 EMEIQLGHSNRQ---MAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGL 1684
Query: 1062 KAEEAEELRLDLEDVKNMYKTQIDELLRQS 1091
EE EE+++ LE + + ELL S
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDAS 1714
Score = 109 bits (272), Expect = 2e-23
Identities = 148/717 (20%), Positives = 290/717 (40%), Gaps = 73/717 (10%)
Query: 428 AEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMF 487
A + E E L EK D+ V+ E L E + L K K LLE L + +
Sbjct: 872 ARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLE 931
Query: 488 RVKEESSSISSLKDEFTQR-------IAEAEKKVQLACKERDAAKKEIKNIKEELA---- 536
+E +S + + K + I + E + KE+ A + ++KN+ EE+
Sbjct: 932 EEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEE 991
Query: 537 -----TRLNSS------ETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKE 585
T+ S +T D L+ +++++ GL++ KL +Q L ++
Sbjct: 992 NISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQ-------TDDLEGSLEQ 1044
Query: 586 NENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVD 645
+ + A L + ++LE +L+ ++ + E ++Q E +KK + + + + QV
Sbjct: 1045 EKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVH 1104
Query: 646 MDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQ- 704
+ ++K + +QA ++ +E+ H A E Q + L+RE+ EE+S LE+A
Sbjct: 1105 SLQFQKKIKELQARIEELEEEIEAEHTLRA--KIEKQRSDLAREL---EEISERLEEASG 1159
Query: 705 ------EEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQ 758
E ++++ DL A + E AA + EL +++ + Q
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ 1219
Query: 759 ELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAAT 818
+L + S + N++A L S+ E+ + + D+ E + A E++
Sbjct: 1220 KLEKEKSELKMEIDDMASNIEA-LSKSKSNIERTCRTVEDQFSE----IKAKDEQQTQLI 1274
Query: 819 EELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYV 878
+L K ++ + + S +E +QL K L + +E R E K+
Sbjct: 1275 HDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMA 1334
Query: 879 RTLEETRKEKTLLNSQLEMER--------------MKVEQERKK----AIFTQETIKEKE 920
L+ +R + LL Q E E+ +V Q R K AI E ++E +
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 921 RK---PFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHD--HSFGPMPISANGSNLYD 975
+K + T + +S + ++ + +D D S +D
Sbjct: 1395 KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFD 1454
Query: 976 AVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKV 1035
V + ++ Q++L+ + E L E+ + + ++L L +N L+E
Sbjct: 1455 KV-LAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQE-- 1511
Query: 1036 KEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQSL 1092
EI L Q+ + + + +E +L++ LE+V+ + + ++LR L
Sbjct: 1512 -EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567
Score = 102 bits (253), Expect = 3e-21
Identities = 209/1054 (19%), Positives = 411/1054 (38%), Gaps = 129/1054 (12%)
Query: 115 VSKPPAKSQRPEEEVKSSLHESLHIG---QSRTPETTESQVKDSSLCVSGETLAAGTSSP 171
+++ A+ + EE++ S L E + QS T +++ + L S L A
Sbjct: 867 LARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKEL 926
Query: 172 KTEGKHEETVNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKE 231
+ EE +N E K + K S D+ +++ + E K L +
Sbjct: 927 TERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEM 986
Query: 232 QKHEDRQSNTPSPPVSTFSSGTSTTSDIEVL-DHESVISESSASSRQETTDSKSSLH--- 287
E+ S S + T D++V D + + + +A Q+T D + SL
Sbjct: 987 TALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK 1046
Query: 288 -----LMQTSFQLLSASACPEYNRLD---DFQKLTESCCSSDAFE------RIDSFSVQS 333
L + +L + + +D D Q++ E + FE +ID V S
Sbjct: 1047 KLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKE-FELSQLQAKIDDEQVHS 1105
Query: 334 LD-SRSVSEINS-----DDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIP 387
L + + E+ + ++E+ + + L I + ++ +E + EE +
Sbjct: 1106 LQFQKKIKELQARIEELEEEIEAE-HTLRAKIEKQRSDLARELEEISERLEEASGATSAQ 1164
Query: 388 TEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDV 447
E + E+ + E+ + +T + D VAE E ++ K+ +
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRV---KQKL 1221
Query: 448 CKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSL-------- 499
K L +++ + + +LSK K+ +E ++D+ +K + + L
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQK 1281
Query: 500 ------KDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEEL----------ATRLNSSE 543
E + R+ E E + K + A ++++ +K ++ A L SS
Sbjct: 1282 ARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSR 1341
Query: 544 -TADLLKEKDEQIRGLMEEGEK-LSKQQLHNSNIIKKLRA----KDKENENMVAKLNKKV 597
DLL+E+ E+ + E ++ LSK + K + +E E KL +++
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 598 KELEEE----------LQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMD 647
+E EE L+ KQ L G+ E + E + +++++++ ++ +
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWK 1461
Query: 648 E-LEEKNRSIQAALDSAYKELTDLHKA-NAAKDSEAQEAALSREMK-AKEELSAALEKAQ 704
+ L+E ++AA + T+L K NA ++ Q L RE K +EE+S E+
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA 1521
Query: 705 E------EARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQ 758
E EA + ++ + + DL++AL+ E + +E + EL Q E + +
Sbjct: 1522 ETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVI 1581
Query: 759 ELSQSVSSTTRPLLRQIENLQATLGSQTSSW-------EKLEKNLSD---RLGESQTLLA 808
E + + R R E LQ+ L ++ S +K+E +L++ +LG S +A
Sbjct: 1582 EKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMA 1641
Query: 809 AAVERERAATEELLANKIQMSS-------MESQNSLLRQENSRFQAQLESEKNRLCKLED 861
+ R +L +++ + ++ Q +++ + N +LE K L + E
Sbjct: 1642 ETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTER 1701
Query: 862 ENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKER 921
+ EL + D V+ L +LE + + + E + +I +EK +
Sbjct: 1702 TRRLSEQELLDASDR-VQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAK 1760
Query: 922 KPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGA 981
K + D A + + ++ H + NL V+
Sbjct: 1761 KAIT----------------DAAMMAEELKKEQDTSAH------LERMKKNLEQTVK-DL 1797
Query: 982 GSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIP-- 1039
+ E Q LK + +I L+ + LE + + + + E KVKE+
Sbjct: 1798 QHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQ 1857
Query: 1040 -----KLRTQLRDLDQRYNTILQMYGEKAEEAEE 1068
K +L+DL + ++ Y +AEEAEE
Sbjct: 1858 AEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891
Score = 98.6 bits (244), Expect = 3e-20
Identities = 124/599 (20%), Positives = 253/599 (42%), Gaps = 62/599 (10%)
Query: 508 AEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKD----------EQIRG 557
AEAEK++ ++ + K+E+ + E + + LL+EK+ E +
Sbjct: 847 AEAEKEMATMKEDFERTKEELA--RSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMD 904
Query: 558 LMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDG---- 613
E E L K ++ +K+L + +E E M ++L K + LE++ LK+ +D
Sbjct: 905 AEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELT 964
Query: 614 --KEEVEKQHREN-IKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDL 670
K E EK EN +K L+ + E+++ +L + L+E ++ L ++ L
Sbjct: 965 LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024
Query: 671 HKANAAKDSEAQ--EAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRT 728
K NA + + E +L +E K + +L A K + + + QE++ DL Q+
Sbjct: 1025 IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIM----DLENDKQQI 1080
Query: 729 EQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSS 788
E+ +KE E+ +LQ ++ + + + + + + + L +IE L+ + ++ +
Sbjct: 1081 EEKLKKKE----FELSQLQAKIDDEQVHSLQFQKKI----KELQARIEELEEEIEAEHTL 1132
Query: 789 WEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQ 848
K+EK SD E + + E A + ++ NK E++ +R++ Q
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNK----KREAEFQKMRRDLEEATLQ 1188
Query: 849 LESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKK 908
E+ L K + ++ EL D R ++ KEK+ L +++ +E K
Sbjct: 1189 HEATAATLRKKQADS---VAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKS 1245
Query: 909 AIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISA 968
+ T + E + FS ++ I ++M + + + SH
Sbjct: 1246 KSNIERTCRTVEDQ-FSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSH----------- 1293
Query: 969 NGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQN 1028
R+ S+I L + ++ L+ ++ K ++ MA L +
Sbjct: 1294 ---------RVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDC 1344
Query: 1029 DELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAE-EAEELRLDLEDVKNMYKTQIDE 1086
D L E+ +E + + +L+ + N+ + + K E +A + +LE+ K ++ E
Sbjct: 1345 DLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1403
Score = 91.3 bits (225), Expect = 5e-18
Identities = 112/558 (20%), Positives = 232/558 (41%), Gaps = 70/558 (12%)
Query: 434 AESQPEALSE-KEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEE 492
A + E L E K+ + + ++ E E ++ SL K K L+ ++L ++ R
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442
Query: 493 SSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNS-SETADLLKEK 551
+++ + F + +AE ++K+ + E +AA+KE +++ EL N+ E D L+
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502
Query: 552 DEQIRGLMEEGEKLSKQ------QLHNSNIIKKLRAKDK--------------------- 584
+ + L EE L++Q L + KKL ++K
Sbjct: 1503 RRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKI 1562
Query: 585 -----ENENMVAKLNKKVKELEEELQHLKQ-----------VLDGKEEVEKQHRENIKKL 628
E + ++L++KV E +EE++ LK+ VLD + KK+
Sbjct: 1563 LRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKM 1622
Query: 629 NSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSR 688
+ E LG M E ++ R++Q L + L D ++N +D + Q A + R
Sbjct: 1623 EGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSN--EDLKEQLAIVER 1680
Query: 689 E----MKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEI- 743
++ EE+ ALE+ + R ++ L + D L + + L +I
Sbjct: 1681 RNGLLLEELEEMKVALEQTERTRRLSEQEL-LDASDRVQLLHSQNTSLINTKKKLEADIA 1739
Query: 744 ---GELQQRLQEAENRNQELSQSVSSTTRPL--LRQIENLQATLGSQTSSWEKLEKNLSD 798
E++ +QE+ N ++ ++++ L++ ++ A L + E+ K+L
Sbjct: 1740 QCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1799
Query: 799 RLGESQTLLAAAVERERAATEEL---LANKIQMSSMESQNSL-----LRQENSRFQAQLE 850
RL E++ L +++ E L N++ + +L ++ Q E
Sbjct: 1800 RLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAE 1859
Query: 851 SEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAI 910
+ + +L+D ++ Q ++++ Y R EE ++ S+ + ++E+ ++A
Sbjct: 1860 EDHKNILRLQDLVDKLQAKVKS----YKRQAEEAEEQANTQLSRCRRVQHELEEAAERAD 1915
Query: 911 FTQETIKEKERKPFSVSS 928
+ + + K V S
Sbjct: 1916 IAESQVNKLRAKSRDVGS 1933
Score = 76.3 bits (186), Expect = 2e-13
Identities = 115/513 (22%), Positives = 215/513 (41%), Gaps = 47/513 (9%)
Query: 596 KVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRS 655
K+K L + + K++ KE+ E+ E + E +EK + LQ + ++L+ + +S
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQ-EKNDLQLQVQS 897
Query: 656 IQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLA 715
L A + L K+ +++ +E L+ ++ +EE+++ L + + +L
Sbjct: 898 ETENLMDAEERCEGLIKSKILLEAKVKE--LTERLEEEEEMNSELVAKKRNLEDKCSSLK 955
Query: 716 IQVGDLRLALQRTEQ---AAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLL 772
+ DL L L + E+ A K L E+ L++ + + + L ++ T L
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ 1015
Query: 773 RQIENLQATLGSQTSSWEKLEKNLSDRLG--ESQTLLAAAVERERAATEELLANKIQMSS 830
+ + + + KLE+ D G E + L A +ER + K++
Sbjct: 1016 VEEDKVNGLIKINA----KLEQQTDDLEGSLEQEKKLRADLERAK--------RKLEGDL 1063
Query: 831 MESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTL 890
SQ S++ EN + Q + +L K E E ++ Q +++ DE V +L+ +K K L
Sbjct: 1064 KMSQESIMDLENDKQQIE-----EKLKKKEFELSQLQAKID---DEQVHSLQFQKKIKEL 1115
Query: 891 LNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSF 950
Q +E ++ E E A T EK+R + R SG A ++ +
Sbjct: 1116 ---QARIEELEEEIE---AEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNK 1169
Query: 951 LSQDE----SHDHSFGPMPISANGSNL--YDAVRMGAGSSIIENLQSQLKLREGEITHLQ 1004
+ E D + A + L A + I+NLQ + E E + L+
Sbjct: 1170 KREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK 1229
Query: 1005 LEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEI---PKLRTQL-RDLDQRYNTILQMYG 1060
+EI ++ +++ + +E++ EI + +TQL DL+ + + G
Sbjct: 1230 MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNG 1289
Query: 1061 E---KAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
E + EE E L L K Q++EL RQ
Sbjct: 1290 ELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 109 bits (272), Expect = 2e-23
Identities = 135/655 (20%), Positives = 285/655 (43%), Gaps = 41/655 (6%)
Query: 440 ALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSL 499
AL +D T+ L +++EK + S ++ +E LK+E+ + + S L
Sbjct: 81 ALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGL 140
Query: 500 KDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLM 559
+ I + + + KERD E+ ++E LA + + + K+E +
Sbjct: 141 SMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETE--RSKEEAEHAIS 198
Query: 560 EEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEK 619
+ +++ ++Q S +K +KE + + A ++ + E++ Q++++ KEE++K
Sbjct: 199 QFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQK---SKEELQK 255
Query: 620 QHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDS 679
++ +K+ + ER K+L + Q+ +L+++N + +E AK+
Sbjct: 256 LEQQ-LKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEE 314
Query: 680 EAQEAAL--SREMKAKEELSAAL---EKAQEEARQQQETLAIQVGDLRLALQRTEQAAAR 734
E + L + K +E++ L E + E Q +ETL Q+ + L+R +A+ +
Sbjct: 315 EVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQI----VGLEREVEASKK 370
Query: 735 KEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTR--PLLRQIENLQATLGSQTSSWEKL 792
+ + R + EL L+E + N+ + ++V++T + L++ E + L + +++
Sbjct: 371 QAELDRKAMDEL---LRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDE 427
Query: 793 EKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESE 852
+ + + + + T+++L N + E+Q R++ + + +L+ +
Sbjct: 428 AQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQ 487
Query: 853 KNRLCKLEDENNRYQVELENLKDE-------------YVRTLEE--TRKEKTLLNSQLEM 897
+N + + N Y L +DE V L+E + KE L+ LE
Sbjct: 488 QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQ 547
Query: 898 ERMKVEQERKKAIFTQETIKEKERKPF-SVSSTPTMSRSSSISGVDMAGL-QTSFLSQDE 955
+R++ E+E KA + + E K F I+ D L Q L Q
Sbjct: 548 QRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVI 607
Query: 956 SHDHSFGPMPISANG--SNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKT 1013
S G + N + LY+ +++ S++ +SQ R ++ L+LEI L +
Sbjct: 608 SERDILGSQLVRRNDELALLYEKIKI--QQSVLNKGESQYNQRLEDMRILRLEIKKLRRE 665
Query: 1014 RSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEE 1068
+ I+A + + E +E+ K RT+ R L++ L ++ + EA +
Sbjct: 666 KGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASD 720
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 108 bits (270), Expect = 3e-23
Identities = 155/770 (20%), Positives = 332/770 (43%), Gaps = 112/770 (14%)
Query: 373 AEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEG--QTVLDKVAEQ 430
A+ K+ V V+ T A ++ S +++ + VSS P G + A +
Sbjct: 289 AKAKANAVRR--VMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARK 346
Query: 431 CEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVK 490
+ EAL EK+ + + + L +R+ + ++K + V
Sbjct: 347 ISGTTALQEALKEKQ------QHIEQLLAERDLERAEVAKATS--------------HVG 386
Query: 491 EESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKE 550
E ++ +D Q + E E K+ +AA +E K EL +L K
Sbjct: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADRE----KVELLNQLEEE------KR 436
Query: 551 KDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENE-----NMVAKL------NKKVKE 599
K E ++ +EE E ++K L + + +K R + E + VA+L NK +
Sbjct: 437 KVEDLQFRVEE-ESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGD 495
Query: 600 LEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVER-------QEKDLGRLQVDMDELEEK 652
++ L L+++ +E++E ++ +++ S+ E +K++ L ++L ++
Sbjct: 496 VDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKE 555
Query: 653 NRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQE 712
N S+++ L+ A KE +D+ +K E A++ +A EEL + K +
Sbjct: 556 NESLKSKLEHANKENSDVIALWKSK----LETAIASHQQAMEELKVSFSKGLGTETAEFA 611
Query: 713 TLAIQVGDLRLALQR----------TEQAAARKE-DYLR-----------HEIGELQQRL 750
L Q+ +RL Q +E+AA KE + LR + + ++ +L
Sbjct: 612 ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 671
Query: 751 QEAENRNQ-ELSQSVSSTTRPLLR--QIENLQATLGSQTSSWEKLEKNLSDRLGESQTLL 807
+AE+++ E+ +++ ++ ++E LQA QT K+ N + +L ++ L
Sbjct: 672 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQT----KVIDNFTSQLKATEEKL 727
Query: 808 AAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQ 867
+A++E K +M + Q ++ + + +E ++ + E +
Sbjct: 728 LDLDALRKASSE----GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 783
Query: 868 VELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVS 927
++L NL++ L E + K L +L++ + K + ++A+ Q +++E K
Sbjct: 784 LKLTNLQEN----LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKE 839
Query: 928 STPTMSRSSSISGV--DMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRM-GAGSS 984
M SS + + ++A ++ F +DE + N ++ + ++M G SS
Sbjct: 840 EQFNML-SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN--DIAEIMKMSGDNSS 896
Query: 985 IIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLT-----NQNDELEEKVKEIP 1039
+ + +L+L+E ++ LQL++ + S + + + +T +Q + ++ +E
Sbjct: 897 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 956
Query: 1040 KLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLR 1089
+L +L DL+++ T + +EL+ E + KT+ +E+L+
Sbjct: 957 ELERKLSDLEKKMET-------SHNQCQELKARYERATSETKTKHEEILQ 999
Score = 102 bits (253), Expect = 3e-21
Identities = 190/951 (19%), Positives = 396/951 (41%), Gaps = 145/951 (15%)
Query: 183 KESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDR--QSN 240
+E KV + +V E I K +E + + + KD+AL +E R +SN
Sbjct: 432 EEEKRKVEDLQFRVEEESI-TKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESN 490
Query: 241 TPSPPVSTFSSGTSTTSDI-EVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSAS 299
P+ V S S + E L+ + +S +E ++ H Q + L
Sbjct: 491 KPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH--QKEIKAL--- 545
Query: 300 ACPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPII 359
Y + K ES S +++ + ++ D ++ + + ++ A+ +
Sbjct: 546 ----YTATEKLSKENESLKS-----KLEHANKENSDVIALWKSKLETAIASHQQAMEELK 596
Query: 360 VNSSTPK-SKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTP-- 416
V+ S ++T E AE K++ L E ++ S + ++ + L +
Sbjct: 597 VSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKV 656
Query: 417 INEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLE 476
I E + L+ + + + AE Q L E ED ++ K+++ E +++ ++
Sbjct: 657 IKEKENSLEAIRSKLDKAEDQH--LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI- 713
Query: 477 EAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELA 536
DN ++ +E+ + +L+ ++ +E +K Q + +AA+K+IK++ E+
Sbjct: 714 ---DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ----QLEAAEKQIKHL--EIE 764
Query: 537 TRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKK 596
SS+ + + +E + L E LS+ + K+L+ L +K
Sbjct: 765 KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQI-----------LKEK 813
Query: 597 VKELEEELQHLKQVLDGKEEVEKQHR--ENIKKLNSMVERQEKDLGRLQVDMDELEEKNR 654
E EE +++ + +E V K H+ E L+S +E+ ++L ++ E +E+
Sbjct: 814 FAEASEEAVSVQRSM--QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREE 871
Query: 655 SIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKE----ELSAALEKAQEEARQQ 710
+ A + ++ ++ K + D+ +Q ++ E++ KE EL L KA E A
Sbjct: 872 QLIKAKEKLENDIAEIMKMSG--DNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL 929
Query: 711 QETLAIQVGDLRLALQRTEQAAARKEDY----LRHEIGELQQRLQEAENRNQELS----Q 762
Q+++ D+ + ++++Q AA+K + L ++ +L+++++ + N+ QEL +
Sbjct: 930 QKSIE----DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
Query: 763 SVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEE-- 820
+ S T ++NLQ TL + + S L E + L A + + A T E
Sbjct: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
Query: 821 ----------------------------------LLANKIQ-MSSMESQNSLLRQENSR- 844
L N ++ + + LL EN +
Sbjct: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
Query: 845 --FQAQLESEK-------NRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQL 895
F+ ++E+ K +L L++EN + EL +DE V + ++ +E+++LN+QL
Sbjct: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDE-VTSHQKLEEERSVLNNQL 1164
Query: 896 EMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDE 955
+E +++++ F ++ +EK S+S T + + T +
Sbjct: 1165 ------LEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE-- 1216
Query: 956 SHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRS 1015
+A+ +L+ S+++ L+S E ++ +L+L++ E R
Sbjct: 1217 -----------NASAKSLH---------SVVQTLESDKVKLELKVKNLELQL--KENKRQ 1254
Query: 1016 IMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEA 1066
+ + T +++ + +I L + + DL QR N L+M E EA
Sbjct: 1255 LSSSSGNTDTQADEDERAQESQIDFLNSVIVDL-QRKNQDLKMKVEMMSEA 1304
Score = 98.2 bits (243), Expect = 4e-20
Identities = 173/782 (22%), Positives = 319/782 (40%), Gaps = 73/782 (9%)
Query: 331 VQSLDSRSVSEINSDDELSGKGYALVPIIVNSSTPKSK---TVESAEGKSEEVNETLVIP 387
V++ D V +N +E K L + S K S + + E+ + L +
Sbjct: 417 VEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALR 476
Query: 388 TEE-AEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKED 446
+E AE+ S P D+ +S + + E ++ +K+ + + Q E S KE
Sbjct: 477 VQEVAELRRRLESNKPAG----DVDMSLSLLQEISSLQEKL--EVTRTDHQREITSLKEH 530
Query: 447 VCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQR 506
E+ ++E + L + EK L + ++LK ++ +E+S +
Sbjct: 531 FGA-----REETHQKEIKALYTATEK--LSKENESLKSKLEHANKENSDV---------- 573
Query: 507 IAEAEKKVQLACKERDAAKKEIK-NIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKL 565
IA + K++ A A +E+K + + L T ++E A+L + ++ E E L
Sbjct: 574 IALWKSKLETAIASHQQAMEELKVSFSKGLGTE--TAEFAELKTQIEKMRLDYQHEIENL 631
Query: 566 SKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENI 625
QQ + A KE E + AKL K +KE E L+ ++ LD E+ E+
Sbjct: 632 QNQQ------DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 685
Query: 626 KKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTD---LHKANAAKDSEAQ 682
E + K+L LQ +E + + + L + ++L D L KA++ SE +
Sbjct: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 745
Query: 683 EAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLA-LQRTEQAAARKEDYLRH 741
+ E K+ +EK E ++ T +Q +L+L LQ ++ ++ L
Sbjct: 746 KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 805
Query: 742 EIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSD--- 798
E+ L+++ EA + +S+ T L ++ E +S EKL +NL+D
Sbjct: 806 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML----SSDLEKLRENLADMEA 861
Query: 799 ---RLGESQTLLAAAVERERAATEELLA----NKIQMSSMESQNSLLRQENSRFQAQLES 851
E + L A E+ E++ N Q++ M + L ++ Q +L
Sbjct: 862 KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 921
Query: 852 EKNRLCKLEDENNRYQVELENLKDEYVRTLEETRK--EKTLLNSQLEMERMKVEQERKKA 909
L+ V+ E + E + EE +K E+ L + + +ME + + KA
Sbjct: 922 ANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA 981
Query: 910 IFTQET--IKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPIS 967
+ + T K K + + + G A + S L Q+ +
Sbjct: 982 RYERATSETKTKHEEILQNLQKTLLDTEDKLKG---AREENSGLLQELEELRKQADKAKA 1038
Query: 968 ANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITH--LQLEIGNLEKTRSIMAEELVK-- 1023
A + DA+++ E ++ L + + T+ LQ E+ L++ EEL K
Sbjct: 1039 AQTAE--DAMQI-MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSK 1095
Query: 1024 --LTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYK 1081
LT +N ++EE KEI L+ Q+ + + + E + AEEL ++V + K
Sbjct: 1096 ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQE---ENVKLAEELGRSRDEVTSHQK 1152
Query: 1082 TQ 1083
+
Sbjct: 1153 LE 1154
Score = 67.0 bits (162), Expect = 9e-11
Identities = 171/823 (20%), Positives = 327/823 (39%), Gaps = 139/823 (16%)
Query: 146 ETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEETVNKESDMKVPTVSLKVSESVIDVKT 205
ET + ++K +L + E L+ S K++ +H NKE+ + K+ ++ +
Sbjct: 536 ETHQKEIK--ALYTATEKLSKENESLKSKLEH---ANKENSDVIALWKSKLETAIASHQQ 590
Query: 206 TMESISNTSTQSLTAETKDIALEPKEQKHE---DRQSNTPSPPVSTFSSGTSTTSDIEVL 262
ME + + ++ L ET + A E K Q + D Q + S + ++E L
Sbjct: 591 AMEELKVSFSKGLGTETAEFA-ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 649
Query: 263 -------------DHESVISESSASSRQETTDSKSSLHLMQTS------FQLLSASACPE 303
E++ S+ + Q + + +L+ +Q + ++L A +
Sbjct: 650 RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQ 709
Query: 304 YNRLDDF----QKLTESCCSSDAFERIDSFSVQSL-----------------------DS 336
+D+F + E DA + S + +S
Sbjct: 710 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 769
Query: 337 RSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEES 396
S I EL G+ L + N S S+ E+ E + + + E +EEA +
Sbjct: 770 SKASSITR--ELQGRELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEASEEAVSVQR 826
Query: 397 GRSATPVNCEQPDI---LVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKE----DVCK 449
T Q + ++SS + + D A+ E E + + + KE D+ +
Sbjct: 827 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 886
Query: 450 TVEFLNE------------KLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSIS 497
++ + +L++R+ + L L KA +F E VK E S
Sbjct: 887 IMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE 946
Query: 498 SLKD------EFTQRIAEAEKKVQLA---CKERDA----AKKEIKNIKEELATRLNSS-- 542
+ K E +++++ EKK++ + C+E A A E K EE+ L +
Sbjct: 947 AAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLL 1006
Query: 543 ETADLLKEKDEQIRGLMEEGEKLSKQQ--------LHNSNIIKKLRAKDK--------EN 586
+T D LK E+ GL++E E+L KQ ++ I + K+K +
Sbjct: 1007 DTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDT 1066
Query: 587 ENMVAKLNKKVKELEE-ELQHLKQVLDGKE--EVEKQHRENIKKLNSMVERQEKDLGRLQ 643
+ AKL ++ L+E L++++++ KE VE Q E +K +E ++ +
Sbjct: 1067 KQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRK---EIETLKQAAAQKS 1123
Query: 644 VDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSRE-MKAKEELSAALEK 702
+ L+E+N + L + E+T K E + + L+ + ++ K+ S ++
Sbjct: 1124 QQLSALQEENVKLAEELGRSRDEVTSHQKL------EEERSVLNNQLLEMKKRESKFIKD 1177
Query: 703 AQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQ 762
A EE Q++++I AL + A K LR+E+ L+ A++ + + Q
Sbjct: 1178 ADEEKASLQKSISI-----TSALLTEKDAELEK---LRNEVTVLRGENASAKSLH-SVVQ 1228
Query: 763 SVSSTTRPLLRQIENLQATLG------SQTSSWEKLEKNLSDRLGESQTLLAAAVERERA 816
++ S L +++NL+ L S +S + + +R ESQ +V +
Sbjct: 1229 TLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQ 1288
Query: 817 ATEELLANKIQMSSMESQNSL---LRQENSRFQAQLESEKNRL 856
+ L K++M S + N L +S Q + +K RL
Sbjct: 1289 RKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRL 1331
Score = 49.3 bits (116), Expect = 2e-05
Identities = 71/336 (21%), Positives = 139/336 (41%), Gaps = 44/336 (13%)
Query: 784 SQTSSWEKLEKNLSDR------LGESQTLLAAAVERERAATEELLANKIQMSSMESQNSL 837
S SS + ++S R L E+ + A + A E L + + + ++ L
Sbjct: 314 SSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDL 373
Query: 838 LRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEM 897
R E ++ + + + L D ++++ +ELE D+ +E +EK L +QLE
Sbjct: 374 ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEE 433
Query: 898 ERMKVEQERKKAIFTQETIKEKERKPFSVSSTP---TMSRSSSISGVDMAGLQTSFLSQD 954
E+ KVE + + +E+I + + + +VS + + ++ ++A L+ S
Sbjct: 434 EKRKVEDLQFRV--EEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNK 491
Query: 955 ESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTR 1014
+ D + + S L + SS+ E L+ + EIT L+ G E+T
Sbjct: 492 PAGD-------VDMSLSLLQEI------SSLQEKLEVTRTDHQREITSLKEHFGAREETH 538
Query: 1015 SIMAEELV----KLTNQNDELEEKVKEI------------PKLRTQLRDLDQRYNTILQM 1058
+ L KL+ +N+ L+ K++ KL T + Q +
Sbjct: 539 QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 598
Query: 1059 Y----GEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+ G + E EL+ +E ++ Y+ +I+ L Q
Sbjct: 599 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQ 634
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 108 bits (269), Expect = 4e-23
Identities = 174/888 (19%), Positives = 377/888 (42%), Gaps = 145/888 (16%)
Query: 258 DIEVLDHESVISESSASS------------RQETTDSKSSLHLMQTSFQLLSASACPEYN 305
+I+ L ESV+ S R+E + +S +Q+ LL E
Sbjct: 814 EIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSD--LLEMKNANEKT 871
Query: 306 RLDD------FQKLTESCCSSDAFERIDSFSVQS-------LDSRSVSEINSDDELSGKG 352
RL++ ++++++C S+ + ++ L+ + + + ++ L
Sbjct: 872 RLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDS 931
Query: 353 YALVPIIVNSSTPKSKTVES--------AEGKSEEVNETLVIPTEEAEMEESGRSATPVN 404
A P + N K +E + K E++N+ ++ + + +S R T
Sbjct: 932 LAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTV 991
Query: 405 CEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQ 464
E+ + L S E + + + + AES L E E + ++ E+ E +
Sbjct: 992 KEELESLRS-----EKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHR 1046
Query: 465 LLSLSKE---KALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKER 521
+ L+++ L E ++ +++ E S + L + +I E ++ + KE
Sbjct: 1047 IEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEV---QILEVQRAKAMVDKEL 1103
Query: 522 DAAKKEIKNIKEELATRLNSSETADL-LKEKDEQIRGLMEEGEKLSKQQ----LHNSNII 576
+A K + + +E AT +N E + L+++ +Q++ M+E E + K L N I
Sbjct: 1104 EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIA 1163
Query: 577 KKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQE 636
R + N+ + K N K+++LE+E++ ++KQ +E + +
Sbjct: 1164 DYERLMKELNQKLTNK-NNKIEDLEQEIK-----------IQKQKQETL----------Q 1201
Query: 637 KDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKE-- 694
+++ LQ + + EEKN I+ L KEL D +A D +A+L E++A +
Sbjct: 1202 EEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAET--DHLILQASLKGELEASQQQ 1259
Query: 695 ---------ELSAALEKAQE----EARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRH 741
E+++ K E A Q Q TL+ + ALQ +AA ++ +
Sbjct: 1260 VEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRV-TALQEECRAAKAEQATVTS 1318
Query: 742 EIGELQQRLQEA--ENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDR 799
E + R+ + +N+ +SQ + T ++ E+L+ + + + NL
Sbjct: 1319 EFESYKVRVHNVLKQQKNKSMSQ---AETEGAKQEREHLEMLIDQLKIKLQDSQNNLQIN 1375
Query: 800 LGESQTLLA---AAVERERAATEELLANKIQ----MSSMESQNSLLRQENSRFQAQLESE 852
+ E QTL + +ER +E ++ + + + S++S+N +++ E+++ +QL S+
Sbjct: 1376 VSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQ 1435
Query: 853 KNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFT 912
L N ++ ++ +L++E+ +T+E +++ + + +QL ++K E + + +
Sbjct: 1436 NEVL------RNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQL--FQLKNEPTTRSPVSS 1487
Query: 913 QETIKE-KERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGS 971
Q+++K +ER+ D+ L ++++E G
Sbjct: 1488 QQSLKNLRERR-----------------NTDLPLLDMHTVTREE------------GEGM 1518
Query: 972 NLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDEL 1031
D + + S+ ++L+ L E T L+ + + E T+ + ++L T D L
Sbjct: 1519 ETTDTESVSSASTYTQSLEQLLNSPE---TKLEPPLWHAEFTKEELVQKLSSTTKSADHL 1575
Query: 1032 EEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNM 1079
++E L + + + ++ E+ +E E+ +LE +KN+
Sbjct: 1576 NGLLRETEATNAILMEQIKLLKSEIRRL-ERNQEREKSAANLEYLKNV 1622
Score = 98.6 bits (244), Expect = 3e-20
Identities = 165/833 (19%), Positives = 331/833 (39%), Gaps = 159/833 (19%)
Query: 405 CEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQ 464
CE+ + L+ + G+ V + E + E E+ K + ++KLEK Q
Sbjct: 617 CEREERLI----LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQ 672
Query: 465 LLSLSKEKALLEEAFDNLKDEMFRVKEESSSIS-------SLKDE--FTQRIAEAEKKVQ 515
+ LS++K +L +L +E ++ E +S S K++ + I + EKK+Q
Sbjct: 673 MKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQ 732
Query: 516 LACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNI 575
L +E+D K ++N E++ ++ LKE ++ EE + ++ Q ++
Sbjct: 733 LMVEEQDNLNKLLEN--EQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESL 790
Query: 576 IKKLRAKDK---ENENMVAKLNKKVKELEEE----LQHLKQVLDGKEEVEKQHRENIKKL 628
K K + + V +L K++K L+EE + LK +L E+ + R+ ++++
Sbjct: 791 AKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEI 850
Query: 629 NSMVERQEKDLGRLQV--DMDELEEKNRSIQAALDSAYKELTDLHKANAA---------- 676
S E + DL ++ + LE +N IQ S +++H
Sbjct: 851 QSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLK 910
Query: 677 ------------------KDSEAQEAALSRE-MKAKEELSAALEKAQEEARQQQETLAIQ 717
KDS A+ ++ + + + +EL +E ++E ++++E +
Sbjct: 911 PLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEE----K 966
Query: 718 VGDLRLALQRTEQA--AARKEDY-LRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLR- 773
+ ++L + ++ ++RKE ++ E+ L+ + ++L Q S LL
Sbjct: 967 INKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEY 1026
Query: 774 -------------------QIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAA---- 810
+IE+L L + T E + + D L +TL + A
Sbjct: 1027 EKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLE 1086
Query: 811 -----VERERAATE-ELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDE-- 862
V+R +A + EL A K+Q +++ E Q QL+ EK +L K E
Sbjct: 1087 VQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELE 1146
Query: 863 ---NNRYQVELENLK-DEYVRTLEETRKEKTLLNSQLE-------MERMKVEQERKKAIF 911
+ Q L N++ +Y R ++E ++ T N+++E +++ K E +++
Sbjct: 1147 LVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITS 1206
Query: 912 TQETIKEKERKPFSVSSTPTMSRS----SSISGVDMAGLQTSF-----LSQDESHDHSFG 962
Q ++++ E K + ++ S + D LQ S SQ + +
Sbjct: 1207 LQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQ 1266
Query: 963 PMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLE---------------- 1006
I++ +++ ++ A E Q L + +T LQ E
Sbjct: 1267 LAEITSEKHKIHEHLKTSA-----EQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFE 1321
Query: 1007 --------IGNLEKTRSIMAEEL------------------VKLTNQNDELEEKVKEIPK 1040
+ +K +S+ E +KL + + L+ V E+
Sbjct: 1322 SYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQT 1381
Query: 1041 LRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQSLS 1093
L+++ L +R+N +LQ K E E ++ M K++ + + Q S
Sbjct: 1382 LQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTS 1434
Score = 89.7 bits (221), Expect = 1e-17
Identities = 158/690 (22%), Positives = 285/690 (41%), Gaps = 93/690 (13%)
Query: 423 VLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNL 482
++ K +C E + E L K T + + E+ +A LL EKA E+ +L
Sbjct: 40 LIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLL----EKAETEQQCLSL 95
Query: 483 KDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEEL-ATRLNS 541
K E ++K+E ++D T ++ +A K+++ + KEI+N+K EL A R
Sbjct: 96 KKENIKMKQE------VEDSVT-KMGDAHKELE---QSHINYVKEIENLKNELMAVRSKY 145
Query: 542 SET-ADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKEN---ENMVAKLNKKV 597
SE A+L K+ +E + +E E+L Q N+ K +K E + L K++
Sbjct: 146 SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQL 205
Query: 598 KELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQ 657
+E + L E QH + K +NS+ QE+ L + +E++E I+
Sbjct: 206 DATTDEKKETVTQLQNIIEANSQHYQ--KNINSL---QEELLQLKAIHQEEVKELMCQIE 260
Query: 658 AALDSAYKELTDLH--KANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLA 715
A+ E+ L+ K N K EA E + ++ + + E L KA A Q + +
Sbjct: 261 ASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELE---NLRKATSNANQDNQICS 317
Query: 716 IQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQI 775
I + Q E + ++ L+ L+E E+++ L V+ +
Sbjct: 318 ILL-----------QENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVT--------YM 358
Query: 776 ENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQN 835
NL+ L E +++ D + L E E LLA + Q +E
Sbjct: 359 NNLKLKL-------EMDAQHIKDEFFHEREDL------EFKINELLLAKEEQGCVIEKLK 405
Query: 836 SLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQL 895
S L N +F +E + L+++ +Q E+ L + + L ++ KEK L ++
Sbjct: 406 SELAGLNKQFCYTVEQHNREVQSLKEQ---HQKEISELNETF---LSDSEKEKLTLMFEI 459
Query: 896 EMERMKVE---QERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLS 952
+ + + E QE+++AI E+++E + T + IS S
Sbjct: 460 QGLKEQCENLQQEKQEAILNYESLREI----MEILQTELGESAGKISQEF-----ESMKQ 510
Query: 953 QDESHDHSFGPMPISA--NGSNLYDAVRMGAGSSIIENLQSQLKL---REGEITHLQLEI 1007
Q S H +A L + V G + E L SQ +L E I +LQ +
Sbjct: 511 QQASDVHELQQKLRTAFTEKDALLETVNRLQGEN--EKLLSQQELVPELENTIKNLQEKN 568
Query: 1008 G----NLEKTRSIMAE---ELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYG 1060
G +L + +++ E ++ LT + D+ K+K + +R ++ G
Sbjct: 569 GVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELG 628
Query: 1061 EKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
+K E+ + +LE N ++E L++
Sbjct: 629 KKVEQTIQYNSELEQKVNELTGGLEETLKE 658
Score = 88.2 bits (217), Expect = 4e-17
Identities = 166/786 (21%), Positives = 307/786 (39%), Gaps = 163/786 (20%)
Query: 414 STPINEGQTVLDKVAEQ------CEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLS 467
S P+ EG + K + E AE++ + LS K++ K + + + + K
Sbjct: 60 SKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKE 119
Query: 468 LSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKE 527
L + + +NLK+E+ V+ + S E K L + +A +
Sbjct: 120 LEQSHINYVKEIENLKNELMAVRSKYS----------------EDKANLQKQLEEAMNTQ 163
Query: 528 IKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKEN- 586
++ + E+L + NS + L+E+ E+IR EE ++QL + KK +N
Sbjct: 164 LE-LSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNI 222
Query: 587 -ENMVAKLNKKVKELEEELQHLKQVLDGKEEVE----------KQHRENIKKLNSM---- 631
E K + L+EEL LK + +EEV+ K+H I KLN +
Sbjct: 223 IEANSQHYQKNINSLQEELLQLKAI--HQEEVKELMCQIEASAKEHEAEINKLNELKENL 280
Query: 632 ---VERQEKDL-GRLQVDMDELE-----------------EKNRSIQAALDSAYKELTDL 670
E EK++ + + +++ L ++N ++ ++ K L D
Sbjct: 281 VKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLED- 339
Query: 671 HKANAAKDSEAQEAALSREMKAKEELSAALE----KAQEEARQQQETLAIQVGDLRLALQ 726
K+ E+Q + L E+ L LE ++E ++E L ++ +L LA +
Sbjct: 340 ----TLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKE 395
Query: 727 ---------RTEQAAARKE----------------DYLRHEIGELQQRL----------- 750
++E A K+ + + EI EL +
Sbjct: 396 EQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTL 455
Query: 751 --------QEAENRNQELSQSVSSTTRPLLRQI-ENLQATLG---------------SQT 786
++ EN QE +++ + LR+I E LQ LG Q
Sbjct: 456 MFEIQGLKEQCENLQQEKQEAILNYES--LREIMEILQTELGESAGKISQEFESMKQQQA 513
Query: 787 SSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQ 846
S +L++ L E LL V R + E+LL+ + + +E+ L+++N +
Sbjct: 514 SDVHELQQKLRTAFTEKDALL-ETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYL 572
Query: 847 AQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQER 906
L L +LE + N L KD+++ L+ + +E + + E E + +
Sbjct: 573 LSLSQRDTMLKELEGKIN----SLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELG 628
Query: 907 KKAIFTQETIKEKERKPFSVS---STPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGP 963
KK T + E E+K ++ + + ++ +Q LS+D+
Sbjct: 629 KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE------- 681
Query: 964 MPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVK 1023
+SA +LY+ + + ++ L + E L+ I LEK +M EE
Sbjct: 682 -VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEE--- 737
Query: 1024 LTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQ 1083
N N LE + + ++TQL Y + +M E +E++EE +DV N+ +
Sbjct: 738 QDNLNKLLENEQVQKLFVKTQL------YGFLKEMGSEVSEDSEE-----KDVVNVLQAV 786
Query: 1084 IDELLR 1089
+ L +
Sbjct: 787 GESLAK 792
Score = 68.2 bits (165), Expect = 4e-11
Identities = 110/581 (18%), Positives = 258/581 (44%), Gaps = 50/581 (8%)
Query: 510 AEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQ 569
A+K++ L K + + K I EEL ++ + T D++K E++ L+ E + +Q
Sbjct: 34 AKKQMMLIQKAKSRCTELEKEI-EELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQC 92
Query: 570 LHNSNIIKKLRAKDK-ENENMVAKLNKKVKELEE-ELQHLKQVLDGKEEVEKQHRENIKK 627
L +KK K K E E+ V K+ KELE+ + ++K++ + K E+ R +
Sbjct: 93 LS----LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNEL-MAVRSKYSE 147
Query: 628 LNSMVERQEKDLGRLQVDMDE-LEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAAL 686
+ +++Q ++ Q+++ E L+ +N S D+ K ++ K + +
Sbjct: 148 DKANLQKQLEEAMNTQLELSEQLKFQNNS----EDNVKKLQEEIEKIRPGFEEQI----- 198
Query: 687 SREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGEL 746
+ +++L A ++ +E Q Q + + + ++ + + + E+ EL
Sbjct: 199 ---LYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKEL 255
Query: 747 QQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQ-TSSWEKLEKNLSDRLGESQT 805
+++ + ++ ++ L++Q E + + + E L K S+ ++Q
Sbjct: 256 MCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQ- 314
Query: 806 LLAAAVERERAATEELLANKIQ-----MSSMESQNSLLRQE-----NSRFQAQLESE--K 853
+ + + +E E+++ K++ + +ESQ+S+L+ E N + + +++++ K
Sbjct: 315 -ICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIK 373
Query: 854 NRLCKLEDENNRYQV-ELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFT 912
+ E E+ +++ EL K+E +E+ + E LN Q VEQ ++
Sbjct: 374 DEFFH-EREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQF---CYTVEQHNREV--- 426
Query: 913 QETIKEKERKPFSVSSTPTMSRSSS---ISGVDMAGLQTSFLS-QDESHDHSFGPMPISA 968
+++KE+ +K S + +S S ++ GL+ + Q E + +
Sbjct: 427 -QSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLRE 485
Query: 969 NGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQN 1028
L + AG I + +S + + ++ LQ ++ + + E + +L +N
Sbjct: 486 IMEILQTELGESAG-KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGEN 544
Query: 1029 DELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEEL 1069
++L + + +P+L +++L ++ L ++ +EL
Sbjct: 545 EKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKEL 585
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 108 bits (269), Expect = 4e-23
Identities = 162/785 (20%), Positives = 330/785 (42%), Gaps = 107/785 (13%)
Query: 366 KSKTVESAEGKSEEVN---ETLVIPTEEAE-MEESGRSATPVNCEQPDILVSSTPINEGQ 421
K T + +EE++ ET+ T E + ++E+ + A D+ +N
Sbjct: 969 KHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALD------DLQAEEDKVNSLN 1022
Query: 422 TVLDKVAEQCEPAESQPEALSE-KEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFD 480
K+ +Q E ES E + + D+ + L L+ + +L L +K L+E
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082
Query: 481 NLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLN 540
E +++ + +L +F ++I E + +++ +E I+ E ATR
Sbjct: 1083 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE----------IEAERATRAK 1132
Query: 541 SS-ETADLLKEKDEQIRGLMEEG-------EKLSKQQLHNSNIIKKLRAKDKENENMVAK 592
+ + +D +E +E L E G E K++ + + L ++E MVA
Sbjct: 1133 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAA 1192
Query: 593 LNKK----VKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDE 648
L KK V EL E++ +L++V E+ + + + I L+S +E K L+
Sbjct: 1193 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT 1252
Query: 649 LEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEAR 708
LE++ + + + L++L + +EA E LSR+++ KE + + L ++++
Sbjct: 1253 LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGE--LSRQLEEKESIVSQLSRSKQAFT 1310
Query: 709 QQQETLAIQVGD---LRLALQRTEQAAARKEDYLRHEI-------GELQQRLQEAEN--- 755
QQ E L Q+ + + AL Q++ D LR + ELQ+ L +A +
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370
Query: 756 ------------RNQELSQSVSSTTRPLL---RQIENLQATLGSQTSSWEKLEKNLSDRL 800
R +EL ++ + L Q+E + A S + ++L+ + D +
Sbjct: 1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLM 1430
Query: 801 G--ESQTLLAAAVERERAATEELLAN---KIQMSSMESQNSL-----LRQENSRFQAQLE 850
E LAAA+++++ +++LA K + S E + SL L E + + E
Sbjct: 1431 VDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYE 1490
Query: 851 SEKNRLCKLEDENNRYQVELENLKDEYV---RTLEETRKEKTLLNSQLEMERMKVEQERK 907
++L ++ EN + E+ +L ++ +T+ E K + Q+E+E+ ++ +
Sbjct: 1491 EALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSR----KQIELEKADIQLALE 1546
Query: 908 KAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPIS 967
+A + ++ +E K + T +S + + L ++ +
Sbjct: 1547 EA---EAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603
Query: 968 ANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQ 1027
A + +A+R+ K EG++ +++++ + + + + L + Q
Sbjct: 1604 AEVRSRNEAIRLK-------------KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQ 1650
Query: 1028 NDE----LEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQ 1083
+ L++ ++ L+ QL +++R N + E EELR LE + K
Sbjct: 1651 LKDTQLHLDDALRGQEDLKEQLAIVERRANLL-------QAEVEELRATLEQTERARKLA 1703
Query: 1084 IDELL 1088
ELL
Sbjct: 1704 EQELL 1708
Score = 102 bits (255), Expect = 2e-21
Identities = 151/674 (22%), Positives = 287/674 (42%), Gaps = 62/674 (9%)
Query: 435 ESQPEALSEKEDVCKTVEF-LNE---KLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVK 490
ES ++ + E +C+T+E L+E K E+ + L L+ +K+ L+ L ++ +
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE 1296
Query: 491 EESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSE-TADLLK 549
S +S K FTQ+ E +++++ E K LA L SS DLL+
Sbjct: 1297 SIVSQLSRSKQAFTQQTEELKRQLE-----------EENKAKNALAHALQSSRHDCDLLR 1345
Query: 550 EK-DEQIRGLMEEGEKLSKQQLHNSNIIKKLRA----KDKENENMVAKLNKKVKELEEE- 603
E+ +E+ G E LSK + K + +E E KL +++++ EE+
Sbjct: 1346 EQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQV 1405
Query: 604 ---------LQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMD-ELEEKN 653
L+ KQ L G+ E E L + +++++++ ++ + + EE
Sbjct: 1406 EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQ 1465
Query: 654 RSIQAALDSAYKELTDLHKA-NAAKDSEAQEAALSREMKAKEELSAALE-------KAQE 705
++A+L + T+L K NA +++ Q + RE K E+ A L K
Sbjct: 1466 AELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIH 1525
Query: 706 EARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVS 765
E + ++ + ++ D++LAL+ E A +E + EL Q E + + E + +
Sbjct: 1526 ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIE 1585
Query: 766 STTRPLLRQIENLQATLGSQTSSWE---KLEKNLSDRLGESQTLLAAAVERERAATEELL 822
R R +E +Q+ L ++ S +L+K + L E + L+ A R+ A T + L
Sbjct: 1586 QLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHA-NRQAAETLKHL 1644
Query: 823 ANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLE 882
+ +Q ++Q L + + Q E K +L +E N Q E+E L+ TLE
Sbjct: 1645 RS-VQGQLKDTQLHL----DDALRGQ-EDLKEQLAIVERRANLLQAEVEELR----ATLE 1694
Query: 883 ETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVD 942
+T + + L +L +V+ + T K+ E + S + + + +
Sbjct: 1695 QTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEE 1754
Query: 943 MA--GLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRM------GAGSSIIENLQSQLK 994
A + + + +E + NL V+ A ++ + Q++
Sbjct: 1755 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ 1814
Query: 995 LREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNT 1054
E I L+ E+ +K + + L K + EL + +E K +L+DL +
Sbjct: 1815 KLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQV 1874
Query: 1055 ILQMYGEKAEEAEE 1068
++ Y +AEEA+E
Sbjct: 1875 KVKSYKRQAEEADE 1888
Score = 102 bits (253), Expect = 3e-21
Identities = 156/712 (21%), Positives = 288/712 (40%), Gaps = 95/712 (13%)
Query: 426 KVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKR---EAQLLSLSKEKALLEEAFDNL 482
K+ + AE++ E + KE+ KT + L + KR E +L++L +EK
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEK---------- 885
Query: 483 KDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSS 542
D +V+ ES ++ ++ Q I +A+ +++ KE ++ + I EL +
Sbjct: 886 NDLQLQVQAESENLLDAEERCDQLI-KAKFQLEAKIKEVTERAEDEEEINAELTAKKRKL 944
Query: 543 ETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEE 602
E D E + I L K+ K++ N +K L + + +AKL ++ K L+E
Sbjct: 945 E--DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQE 1002
Query: 603 ELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDS 662
Q L +E+ + KL VE E L + + +LE R ++ L
Sbjct: 1003 AHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKL 1062
Query: 663 AYKELTDLHKANAAKDSEAQE-----AALSREMKAKEELSAALEKAQEEARQQQETLAIQ 717
A + + DL D ++ L +++ ++ L +K +E + + E L +
Sbjct: 1063 AQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE 1122
Query: 718 VGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEA---ENRNQELSQSVSSTTRPLLRQ 774
+ R +TE+ ++ DY R E+ EL +RL+EA + EL++ + L R
Sbjct: 1123 IEAERATRAKTEK---QRSDYAR-ELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 1178
Query: 775 IENLQ------------------ATLGSQTSSW----EKLEKNLSDRLGESQTLLAA--A 810
+E A LG Q + +KLEK S+ E L ++ +
Sbjct: 1179 LEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMES 1238
Query: 811 VERERAATEELLA-------------NKIQ--MSSMESQNSLLRQENSRFQAQLESEKNR 855
V + +A E++ +IQ +S + +Q S L+ E QLE +++
Sbjct: 1239 VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI 1298
Query: 856 LCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQET 915
+ +L + + E LK R LEE K K L L+ R + R++ QE
Sbjct: 1299 VSQLSRSKQAFTQQTEELK----RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354
Query: 916 IKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYD 975
E +R +S+++S +T + + E + + + S
Sbjct: 1355 KAELQR---------ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSE--- 1402
Query: 976 AVRMGAGSSIIENLQSQLKLREGEITHLQLEI-------GNLEKTR----SIMAEELVKL 1024
++ A ++ +L+ + +GE+ L +++ L+K + ++AE K
Sbjct: 1403 -EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC 1461
Query: 1025 TNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDV 1076
ELE +KE L T+L L Y L E + L ++ D+
Sbjct: 1462 EESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADL 1513
Score = 75.1 bits (183), Expect = 3e-13
Identities = 106/531 (19%), Positives = 218/531 (41%), Gaps = 59/531 (11%)
Query: 592 KLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEE 651
KL K+K L + + K++ KEE +K E K E +EK L L + ++L+
Sbjct: 832 KLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEK-LVTLVQEKNDLQL 890
Query: 652 KNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQ 711
+ ++ L A + L KA +++ +E ++ + +EE++A L + + +
Sbjct: 891 QVQAESENLLDAEERCDQLIKAKFQLEAKIKE--VTERAEDEEEINAELTAKKRKLEDEC 948
Query: 712 ETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGEL-------------QQRLQEAENR-- 756
L + DL L L + E+ E+ +++ EL ++ LQEA +
Sbjct: 949 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQAL 1008
Query: 757 -----NQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAV 811
++ S++ T L +Q+E+L+++L + LE+N G+ + + +
Sbjct: 1009 DDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESIL 1068
Query: 812 ERE---RAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDE---NNR 865
+ E + E L + ++S+ + +FQ +++ + R+ +LE+E
Sbjct: 1069 DLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA 1128
Query: 866 YQVELENLKDEYVRTLEETRKE----------KTLLNSQLEMERMKVEQERKKAIFTQET 915
+ + E + +Y R LEE + + LN + E E +K+ ++ ++A E
Sbjct: 1129 TRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA 1188
Query: 916 IKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYD 975
+ RK + S + ++ V + + E D S +S + +NL
Sbjct: 1189 MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANL-- 1246
Query: 976 AVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKV 1035
I L+ QL G+ +Q + L +S + E +L+ Q +E E V
Sbjct: 1247 -------EKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIV 1299
Query: 1036 KEIPK-----------LRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLED 1075
++ + L+ QL + ++ N + + + LR E+
Sbjct: 1300 SQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEE 1350
Score = 71.6 bits (174), Expect = 4e-12
Identities = 159/802 (19%), Positives = 320/802 (39%), Gaps = 116/802 (14%)
Query: 108 TIQKSPVVSKPPAKSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAG 167
T+Q +V+ K E+ + + Q E +E +++ L S E+++
Sbjct: 1183 TLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKS 1242
Query: 168 TSS------------PKTEGKHEETVNKESDMKVPTVSLKVSESVI----DVKTTMESIS 211
++ + GK+EE S++ L+ + + K ++ S
Sbjct: 1243 KANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQL 1302
Query: 212 NTSTQSLTAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHE-SVISE 270
+ S Q+ T +T+++ + +E E++ N + + S+ D ++L + E
Sbjct: 1303 SRSKQAFTQQTEELKRQLEE---ENKAKNALAHALQ------SSRHDCDLLREQYEEEQE 1353
Query: 271 SSASSRQETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDAFERIDSF- 329
A ++ + + S + +T ++ + E +KL + D+ E++++
Sbjct: 1354 GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK--KKLAQRL--QDSEEQVEAVN 1409
Query: 330 ----SVQSLDSRSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLV 385
S++ R E+ + +L + K + + K EE L
Sbjct: 1410 AKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAEL- 1468
Query: 386 IPTEEAEMEESGRSATPV----NCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEAL 441
EA ++ES +T + N + + T E + + ++A+ E + +
Sbjct: 1469 ----EASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI 1524
Query: 442 SEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKD 501
E E K +E LEK + QL LEEA L+ E ++ ++ +K
Sbjct: 1525 HELEKSRKQIE-----LEKADIQLA--------LEEAEAALEHEEAKILRIQLELTQVKS 1571
Query: 502 EFTQRIAEAEKKV--------------QLACKERDAAKKEIKNIKEELATRLNSSE--TA 545
E ++IAE ++++ Q A ++ E +K+++ LN E +
Sbjct: 1572 EIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLS 1631
Query: 546 DLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIK---KLRAKDKENENMVAKLNKKVKELEE 602
++ E ++ L +L QLH + ++ L+ + E L +V+EL
Sbjct: 1632 HANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRA 1691
Query: 603 ELQHL--------KQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNR 654
L+ +++LD E V+ H +N +++ ++ E DL +LQ E+E+ +R
Sbjct: 1692 TLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTK-KKLETDLMQLQ---SEVEDASR 1747
Query: 655 SIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETL 714
+ A + A K +TD A ++ E+K +++ SA LE+ ++ Q
Sbjct: 1748 DARNAEEKAKKAITD-------------AAMMAEELKKEQDTSAHLERMKKNLEQ----- 1789
Query: 715 AIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQ 774
V DL+ L EQ A + + +I +L+ R++E E E Q ++ + LR+
Sbjct: 1790 --TVKDLQHRLDEAEQLALKGG---KKQIQKLETRIRELE-FELEGEQKKNTESVKGLRK 1843
Query: 775 IENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQ 834
E L Q+ K L D + + Q + + + A E+ AN ++Q
Sbjct: 1844 YERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQ--ANAHLTKFRKAQ 1901
Query: 835 NSLLRQENSRFQAQLESEKNRL 856
+ L E A ES+ N+L
Sbjct: 1902 HELEEAEERADIA--ESQVNKL 1921
Score = 70.5 bits (171), Expect = 8e-12
Identities = 87/450 (19%), Positives = 186/450 (41%), Gaps = 40/450 (8%)
Query: 678 DSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKED 737
++E + A + E + ++ A E ++E ++ TL + DL+L +Q + E+
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 738 ----------YLRHEIGELQQRLQEAENRNQELS---QSVSSTTRPLLRQIENLQATLGS 784
L +I E+ +R ++ E N EL+ + + L + I++L+ TL
Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964
Query: 785 ---QTSSWEKLEKNLSDRLGESQTLLAAAVERERA-------ATEELLANKIQMSSMESQ 834
+ + E KNL++ L +A ++A A ++L A + +++S+
Sbjct: 965 VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024
Query: 835 NSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYV------RTLEETRKEK 888
S L Q+ ++ LE EK LE + + +L+ ++ + + L+E K+K
Sbjct: 1025 KSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKK 1084
Query: 889 TLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQT 948
QL+ KVE E+ + Q+ IKE + + + R++
Sbjct: 1085 DFEYCQLQS---KVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYA 1141
Query: 949 SFLSQ-----DESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLRE---GEI 1000
L + +E+ + + ++ + +R + +++ LR+ +
Sbjct: 1142 RELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSV 1201
Query: 1001 THLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYG 1060
L +I NL++ + + +E + + D+L ++ + K + L + + L
Sbjct: 1202 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEAR 1261
Query: 1061 EKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
K EE + +L K+ +T+ EL RQ
Sbjct: 1262 GKNEEIQRSLSELTTQKSRLQTEAGELSRQ 1291
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 105 bits (262), Expect = 2e-22
Identities = 189/876 (21%), Positives = 368/876 (42%), Gaps = 98/876 (11%)
Query: 121 KSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEET 180
++ +PEE+ SL TP S DSSL S S G E+
Sbjct: 259 RTSQPEEKKDVSLDSDA--AGPPTPCKPSSPGADSSL--SSAVGKGRQGSGARPGLPEKE 314
Query: 181 VNKESDMKVPTVSLKVSESVIDVKT--TMESISNTSTQSLTAETKDIALEPKEQKHEDRQ 238
N++S+ K+ +++ K T + S + +T D +E +
Sbjct: 315 ENEKSEPKI-------CRNLVTPKADPTGSEPAKASEKEAPEDTVDAG---EEGSRREEA 364
Query: 239 SNTPSPPVSTFSSGTSTTS-DIEVLDH--ESVISESSASSRQETTD------SKSSLHLM 289
+ P S G+S S ++E+ +H E +S+S AS + S+ S HL+
Sbjct: 365 AKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLL 424
Query: 290 QTS-FQLLSASACPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDS------------ 336
+ AC + + + +S S D + S ++ S
Sbjct: 425 DVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSP 484
Query: 337 -RSVS-------------EINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVN- 381
RS++ E +EL A + + ++ ++ + +A K +E +
Sbjct: 485 PRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHS 544
Query: 382 --ETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPE 439
E L EEAE E + +P P++ S+ P+ + + + + E A +Q
Sbjct: 545 QAEELGPGQEEAEDPEEKVAVSPTPPVSPEVR-STEPVAPPEQLSEAALKAMEEAVAQVL 603
Query: 440 ALSEK---EDVCKTVEFLNEKL-EKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSS 495
++ E + ++ L EKL ++ E ++L L ++K E++ +L++ + + EE +
Sbjct: 604 EQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQK---EQSLSSLRERLQKAIEEEEA 660
Query: 496 ISSLKDEFTQRIAEAEKKVQLACK-ERDAAKKE----IKNIKEELATRLNSSETADLLKE 550
+++E +QR++ +VQ + + + D + E ++ ++EEL ++ +E A L ++
Sbjct: 661 --RMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQ-QKAERASLEQK 717
Query: 551 KDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQV 610
+ + L EE E K + N K+ +A + E + + + V LE+E H ++
Sbjct: 718 NRQMLEQLKEEIEASEKSEQAALNAAKE-KALQQLREQLEGERKEAVATLEKE--HSAEL 774
Query: 611 LDGKEEVEKQHRENIKKLNSMV-ERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTD 669
+E +HRE + L + E Q+K+ +LQ + ++E + + EL+
Sbjct: 775 ERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSS 834
Query: 670 LHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEAR-QQQETLAIQVGDLRLALQRT 728
L + + E L K KEE + KA+E+ ++++ A +G L L+R
Sbjct: 835 LLREKRQEVEGEHERRLD---KMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERL 891
Query: 729 EQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSS 788
++A R+ + +R E +RL++ R++E + + L + ++++A L
Sbjct: 892 QRAHERELETVRQE---QHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLAL---- 944
Query: 789 WEKLEKNLSDRLGESQTLLAAAVERERAA-TEELLANKIQMSSMESQNSLLRQENSRFQA 847
LE E Q LL V+R+ A +EE A Q+ + +++ L Q N + +
Sbjct: 945 ---LEVQEETARREKQQLLD--VQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLRE 999
Query: 848 QLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERK 907
L+ + R KLE + + Q + + L+ + E +K++ LL + VE+
Sbjct: 1000 ILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLL------REVTVEENNA 1053
Query: 908 KAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDM 943
F + E RK + T +S S S S D+
Sbjct: 1054 SPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL 1089
Score = 77.0 bits (188), Expect = 9e-14
Identities = 180/893 (20%), Positives = 346/893 (38%), Gaps = 137/893 (15%)
Query: 122 SQRPEEEVKSSLHESLHIGQSRT-PETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEET 180
SQ ++E++S + L S P +Q SL E P E K E
Sbjct: 452 SQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQP--EWKEAEE 509
Query: 181 VNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSN 240
+ ++S ++SL++S + + Q AE E E E++ +
Sbjct: 510 LGEDS---AASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDP-EEKVAV 565
Query: 241 TPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASA 300
+P+PPVS T + E L ++ + A ++ D + L Q Q L
Sbjct: 566 SPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKL 625
Query: 301 CPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIV 360
C E + R+ QSL S
Sbjct: 626 CQE---------------EEEEILRLHQQKEQSLSS------------------------ 646
Query: 361 NSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEG 420
K +E E + E E+ + A+++ S ++ I E
Sbjct: 647 -LRERLQKAIEEEEARMRE-EESQRLSWLRAQVQSS------TQADEDQIRA------EQ 692
Query: 421 QTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKL---EKREAQLLSLSKEKAL--L 475
+ L K+ E+ E ++ + E S ++ + +E L E++ EK E L+ +KEKAL L
Sbjct: 693 EASLQKLREELE-SQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQL 751
Query: 476 EEAFDNLKDEMFRVKEESSS------ISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIK 529
E + + E E+ S SSL+ + + ++ +KK+Q A ++ +A ++
Sbjct: 752 REQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCL 811
Query: 530 NIKEELATRLN------SSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKD 583
E + + E + LL+EK +++ G E +L K + + ++ K R +
Sbjct: 812 GQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEG--EHERRLDKMKEEHQQVMAKAREQY 869
Query: 584 KENE---------NMVAKLNKKVKELEEELQHLKQVLDGK-EEVEKQHRENIKKLNSM-- 631
+ E ++ +L + + E EL+ ++Q + E++ ++HRE +KL +
Sbjct: 870 EAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLEL 929
Query: 632 -VERQEKDL-GRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAA----KDSEAQEAA 685
+E + KD+ RL + + E R Q LD + +A A ++++ +
Sbjct: 930 DLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTH 989
Query: 686 LSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRH---- 741
L + + E+ L+ + + Q + L Q L+ E A +K+ LR
Sbjct: 990 LLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVE 1049
Query: 742 ------------EIGELQQRLQEAENRNQELSQSVSSTTRPLL------RQIENLQATLG 783
I +L++ L N+ +E+S S+S + L + +L + G
Sbjct: 1050 ENNASPHFEPDLHIEDLRKSL--GTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEG 1107
Query: 784 SQTSSWEKLEKNLSDRLGESQTLLAAAVE---RERAATEELLANKIQMSSMESQNSLLRQ 840
S ++ + + QT L AA + E A+ +E+ + + ++E L +
Sbjct: 1108 VALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEK 1167
Query: 841 EN---SRFQAQLESEKNRLCKLEDENNRYQVEL-ENLKDEYVRTLEETRKEKTLLNSQLE 896
E ++ + N L K E++ N+ + L E DE TL + +K + +
Sbjct: 1168 ETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDE--GTLGGSPTKKAVTFDLSD 1225
Query: 897 MERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTS 949
M+ + E + +E +++ + STP+++ S I G+ + Q S
Sbjct: 1226 MDSLSSESSESFSPPHREWWRQQR-----IDSTPSLT-SRKIHGLSHSLRQIS 1272
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 105 bits (262), Expect = 2e-22
Identities = 157/722 (21%), Positives = 302/722 (41%), Gaps = 121/722 (16%)
Query: 426 KVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKR---EAQLLSLSKEKALLEEAFDNL 482
K+ + AE++ E + KE+ KT E L + KR E ++++L +EK L+
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898
Query: 483 KDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQ--------LACKER------DAAKKEI 528
D + +E + K + +I E ++ + L K+R KK+I
Sbjct: 899 ADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958
Query: 529 KNIKEELA-TRLNSSETADLLKEKDEQIRGLMEEGEKLSK-----QQLHNSNIIKKLRAK 582
+++ LA T + +K E++ GL E KL+K Q+ H + +
Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEE 1018
Query: 583 DKENENMVAK--LNKKVKELEEELQHLKQVLDGKEEVEKQHRENIK-------------- 626
DK N AK L ++V +LE L+ K++ E +++ ++K
Sbjct: 1019 DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQ 1078
Query: 627 KLNSMVERQEKDLGRLQVDMDE-------LEEKNRSIQAALDSAYKELTDLHKANAAKDS 679
+LN ++++E ++ LQ +++ L++K + +QA ++ +E+ + +A+ AK +
Sbjct: 1079 QLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEI-EAERASRAK-A 1136
Query: 680 EAQEAALSREMKAKEELSAALEKA------QEEARQQQETLAIQVG-DLRLALQRTEQAA 732
E Q + LSRE+ EE+S LE+A Q E +++E ++ DL + + E A
Sbjct: 1137 EKQRSDLSREL---EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATA 1193
Query: 733 ARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKL 792
A + EL +++ + Q+L + S + N++ T+ +++EK+
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNME-TVSKAKANFEKM 1252
Query: 793 EKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESE 852
+ L D+L E +T E++R E + +Q + L E+ F QL+ +
Sbjct: 1253 CRTLEDQLSEIKT---KEEEQQRLINE-----------LSAQKARLHTESGEFSRQLDEK 1298
Query: 853 KNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFT 912
+ +L + ++E LK R LEE K K+ L L+ R + R++
Sbjct: 1299 DAMVSQLSRGKQAFTQQIEELK----RQLEEETKAKSTLAHALQSARHDCDLLREQYEEE 1354
Query: 913 QETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSN 972
QE E +R MS+++S +T + + E + +
Sbjct: 1355 QEAKAELQRG---------MSKANSEVAQWRTKYETDAIQRTEELEEAK----------- 1394
Query: 973 LYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDE-- 1030
+ L +L+ E + + + +LEKT+ + E+ L +
Sbjct: 1395 --------------KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSN 1440
Query: 1031 -----LEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQID 1085
L++K + K+ L + Q+Y +E+ L +L VKN Y+ +D
Sbjct: 1441 AACIALDKKQRNFDKV---LAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLD 1497
Query: 1086 EL 1087
L
Sbjct: 1498 HL 1499
Score = 105 bits (261), Expect = 3e-22
Identities = 147/751 (19%), Positives = 315/751 (41%), Gaps = 99/751 (13%)
Query: 353 YALVPIIVNSSTPK--SKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDI 410
+ + P++ ++ T K + E E EE+ +T EA+ +E + E+ D+
Sbjct: 838 FKIKPLLKSAETEKEMANMKEEFEKTKEELAKT------EAKRKELEEKMVTLMQEKNDL 891
Query: 411 LVSSTPINEGQTVLDKVAEQCEPAESQPEA-LSEKEDVCKTVEFLNEKLEKREAQLLSLS 469
+ + ++ +Q + Q EA + E + + E +N +L ++ +L
Sbjct: 892 QLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL---E 948
Query: 470 KEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIK 529
E + L++ D+L+ + +V++E + + T+ +A ++ + KE+ A ++ +
Sbjct: 949 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1008
Query: 530 NIKEELATRLNSSETADLLKEKDEQ----IRGLMEEGEKL------SKQQLHNSNIIKKL 579
++L + T K K EQ + G +E+ +KL +K++L + +
Sbjct: 1009 QTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE 1068
Query: 580 RAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDL 639
D EN+ +LN+K+K+ E E+ +L+ ++ ++ + Q ++ IK+L + +E E+++
Sbjct: 1069 STMDTENDKQ--QLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEI 1126
Query: 640 GRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAA--KDSEAQEAALSREMKAKEELS 697
+ + E++ + L+ + L + A +A + ++ +EA + + EE +
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEST 1186
Query: 698 AALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRN 757
E R++ ++G+ +LQR +Q +++ L+ EI +L ++
Sbjct: 1187 LQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNME------ 1240
Query: 758 QELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAA 817
T+ +++EK+ + L D+L E +T E++R
Sbjct: 1241 -----------------------TVSKAKANFEKMCRTLEDQLSEIKT---KEEEQQRLI 1274
Query: 818 TEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEY 877
E + +Q + L E+ F QL+ + + +L + ++E LK
Sbjct: 1275 NE-----------LSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELK--- 1320
Query: 878 VRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSS 937
R LEE K K+ L L+ R + R++ QE E +R MS+++S
Sbjct: 1321 -RQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQR---------GMSKANS 1370
Query: 938 ISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDA-VRMGAGSSIIENLQSQLKLR 996
+T + + E + + + L DA + A +S +L+ +
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKL-----AQRLQDAEEHVEAVNSKCASLEKTKQRL 1425
Query: 997 EGEITHLQLEIGN-------LEKTR----SIMAEELVKLTNQNDELEEKVKEIPKLRTQL 1045
+ E+ L +++ L+K + ++AE K ELE KE L T+L
Sbjct: 1426 QNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTEL 1485
Query: 1046 RDLDQRYNTILQMYGEKAEEAEELRLDLEDV 1076
+ Y L E + L+ ++ D+
Sbjct: 1486 FKVKNAYEESLDHLETLKRENKNLQQEISDL 1516
Score = 98.6 bits (244), Expect = 3e-20
Identities = 205/966 (21%), Positives = 405/966 (41%), Gaps = 94/966 (9%)
Query: 148 TESQVKDSSLCVSG--ETLAAGTSSPKT-EGKHEETVNKESDMKVPTVSLKVSESVIDVK 204
TE++VK+ + ++G ET+A T K + H++T++ + M+ V+ ++ K
Sbjct: 975 TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD-DLQMEEDKVN-----TLTKAK 1028
Query: 205 TTMESISNTSTQSLTAETK-DIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLD 263
T +E + SL E K + LE ++K E S T +D + L+
Sbjct: 1029 TKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE-------STMDTENDKQQLN 1081
Query: 264 HESVISESSASSRQETTDSKSSLHL-MQTSFQLLSASACPEYNRLDDFQKLTESCCSSDA 322
+ E S+ Q + + +L + +Q + L A R+++ ++ E+ +
Sbjct: 1082 EKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQA-------RIEELEEEIEA----ER 1130
Query: 323 FERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNE 382
R + +S SR + EI+ E +G G I +N K + E + + +
Sbjct: 1131 ASRAKAEKQRSDLSRELEEISERLEEAG-GATSAQIEMN----KKREAEFQKMRRDLEES 1185
Query: 383 TLVIPTEEAEMEESGRSATPVNCEQPDIL--VSSTPINEGQTVLDKVAEQCEPAESQPEA 440
TL A + + + EQ D L V E + ++ + E+ +A
Sbjct: 1186 TLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKA 1245
Query: 441 LSEKEDVCKTVEF----LNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSI 496
+ E +C+T+E + K E+++ + LS +KA L ++ S +
Sbjct: 1246 KANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQL 1305
Query: 497 SSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIR 556
S K FTQ+I E +++++ K + +++ + + DLL+E+ E+ +
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHD----------CDLLREQYEEEQ 1355
Query: 557 GLMEEGEK-LSKQQLHNSNIIKKLRA----KDKENENMVAKLNKKVKELEEELQHLKQVL 611
E ++ +SK + K + +E E KL +++++ EE ++ +
Sbjct: 1356 EAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKC 1415
Query: 612 DGKEEVEKQHRENIKKLNSMVERQEKD---LGRLQVDMD----ELEEKNRSIQAALDSAY 664
E+ +++ + ++ L VER L + Q + D E ++K QA L+++
Sbjct: 1416 ASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQ 1475
Query: 665 KEL----TDLHKA-NAAKDSEAQEAALSREMK-AKEELSAALEKAQE------EARQQQE 712
KE T+L K NA ++S L RE K ++E+S E+ E E + ++
Sbjct: 1476 KESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKK 1535
Query: 713 TLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLL 772
L + +L+ +L+ E + +E + EL Q E + + E + + R L
Sbjct: 1536 QLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHL 1595
Query: 773 RQIENLQATLGSQTSSWE---KLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMS 829
R +E++Q+TL ++ S +++K + L E + L A R+ A E L N
Sbjct: 1596 RVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHA-NRQAA---EALRNLRNTQ 1651
Query: 830 SMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRK--E 887
+ L + R Q L K +L +E N Q E+E L+ RT E RK E
Sbjct: 1652 GILKDTQLHLDDAIRGQDDL---KEQLAMVERRANLMQAEVEELRASLERT-ERGRKMAE 1707
Query: 888 KTLLNSQLEMERMKVEQ----ERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDM 943
+ LL++ ++ + + KK + T I + + + + + + +
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETD--ISQIQGEMEDIVQEARNAEEKAKKAITD 1765
Query: 944 AGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSI-IENLQSQLKLREGEITH 1002
A + L +++ M + + +R+ + ++ + Q++ E +
Sbjct: 1766 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1825
Query: 1003 LQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEK 1062
L+ E+ + +K + L K + EL + +E K +L+DL + T ++ Y +
Sbjct: 1826 LESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQ 1885
Query: 1063 AEEAEE 1068
AEEAEE
Sbjct: 1886 AEEAEE 1891
Score = 81.3 bits (199), Expect = 5e-15
Identities = 159/766 (20%), Positives = 319/766 (41%), Gaps = 99/766 (12%)
Query: 127 EEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKT-EGKHEETVNKES 185
E+ KS L ++ S ++++ +C TL S KT E + + +N+ S
Sbjct: 1222 EKEKSELKMEINDLASNMETVSKAKANFEKMC---RTLEDQLSEIKTKEEEQQRLINELS 1278
Query: 186 DMK--VPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSNTPS 243
K + T S + S +D K M S + Q+ T + +++ K Q E+ ++
Sbjct: 1279 AQKARLHTESGEFSRQ-LDEKDAMVSQLSRGKQAFTQQIEEL----KRQLEEETKAK--- 1330
Query: 244 PPVSTFSSGT-STTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASACP 302
ST + S D ++L E E A + + SK++ + Q + A
Sbjct: 1331 ---STLAHALQSARHDCDLL-REQYEEEQEAKAELQRGMSKANSEVAQWRTKY-ETDAIQ 1385
Query: 303 EYNRLDDFQKLTESCCSSDAFERIDSFSVQ--SLDSRSVSEINSDDELS---GKGYALVP 357
L++ +K DA E +++ + + SL+ N ++L + A
Sbjct: 1386 RTEELEEAKKKLAQRLQ-DAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACI 1444
Query: 358 IIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPV----NCEQPDILVS 413
+ K + + K EE L EA +ES +T + N + +
Sbjct: 1445 ALDKKQRNFDKVLAEWKQKYEETQAEL-----EASQKESRSLSTELFKVKNAYEESLDHL 1499
Query: 414 STPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEF----LNEKLEKREAQLLSLS 469
T E + + ++++ E + + E E V K ++ L LE+ EA L
Sbjct: 1500 ETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEE 1559
Query: 470 KEKALLEEAFDNLKDEMFR-VKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAA---K 525
+ ++ + +K E+ R + E+ + LK + + + + + R+ A K
Sbjct: 1560 GKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIK 1619
Query: 526 KEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKD-- 583
K+++ E+ +LN + ++ E +R L L QLH + I R +D
Sbjct: 1620 KKMEGDLNEMEIQLNHAN-----RQAAEALRNLRNTQGILKDTQLHLDDAI---RGQDDL 1671
Query: 584 KENENMVAK----LNKKVKELEEELQHLK--------QVLDGKEEVEKQHRENIKKLNSM 631
KE MV + + +V+EL L+ + ++LD E V+ H +N +N+
Sbjct: 1672 KEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTK 1731
Query: 632 VERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMK 691
++ E D+ ++Q +M+++ ++ R+ + + A K +TD A ++ E+K
Sbjct: 1732 -KKLETDISQIQGEMEDIVQEARNAE---EKAKKAITDA-------------AMMAEELK 1774
Query: 692 AKEELSAALEKAQEEARQQQETLAIQVGDL-RLALQ-----------RTEQAAARKEDYL 739
+++ SA LE+ ++ Q + L +++ + +LAL+ R + + E
Sbjct: 1775 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQ 1834
Query: 740 RHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQ---IENLQATLGSQTSSWEKLEKNL 796
+H + E + L++ E R +EL+ + +LR ++ LQ + + E+ E+
Sbjct: 1835 KHNV-EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQS 1893
Query: 797 SDRLGESQTLLAAAVE-RERAATEELLANKIQMSSMESQNSLLRQE 841
+ L + + L E +ERA E NK+++ S E ++ +E
Sbjct: 1894 NVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 80.1 bits (196), Expect = 1e-14
Identities = 113/520 (21%), Positives = 216/520 (41%), Gaps = 53/520 (10%)
Query: 592 KLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEE 651
KL K+K L + + K++ + KEE EK +E + K + + E+ + L + ++L+
Sbjct: 835 KLYFKIKPLLKSAETEKEMANMKEEFEKT-KEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 652 KNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQ 711
+ ++ AL A + L K +++ +E ++ + +EE++A L + + +
Sbjct: 894 QVQAEADALADAEERCDQLIKTKIQLEAKIKE--VTERAEDEEEINAELTAKKRKLEDEC 951
Query: 712 ETLAIQVGDLRLALQRTEQ---AAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTT 768
L + DL L L + E+ A K L E+ L + + + + L ++ T
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT- 1010
Query: 769 RPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQM 828
L ++ + + + T + KLE+ + D G + ++ ERA K++
Sbjct: 1011 ---LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA------KRKLEG 1061
Query: 829 SSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEK 888
+Q S + EN + Q +L K E E + Q ++E DE ++ +K K
Sbjct: 1062 DLKLAQESTMDTENDKQQL-----NEKLKKKEFEMSNLQGKIE---DEQALAIQLQKKIK 1113
Query: 889 TLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQT 948
L Q +E ++ E E ++A EK+R S R G A ++
Sbjct: 1114 EL---QARIEELEEEIEAERA---SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE- 1166
Query: 949 SFLSQDESHDHSFGPMPISANGSNLYD-----AVRMGAGSSI------IENLQSQLKLRE 997
++ + F M S L A+R S+ I++LQ + E
Sbjct: 1167 ----MNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLE 1222
Query: 998 GEITHLQLEIGNL-------EKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQ 1050
E + L++EI +L K ++ + L +Q E++ K +E +L +L
Sbjct: 1223 KEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKA 1282
Query: 1051 RYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ 1090
R +T + + +E + + L K + QI+EL RQ
Sbjct: 1283 RLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ 1322
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 105 bits (261), Expect = 3e-22
Identities = 149/774 (19%), Positives = 336/774 (43%), Gaps = 85/774 (10%)
Query: 373 AEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEG--QTVLDKVAEQ 430
A+ K+ V V+ T A ++ S +++ + VSS P G + A +
Sbjct: 289 AKAKANAVRR--VMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARK 346
Query: 431 CEPAESQPEALSEK----EDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDN----L 482
+ EAL EK E + + ++ K + + + +E AL + D L
Sbjct: 347 ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLEL 406
Query: 483 KDEMFRVKEESSSISSLKDEFTQRIAEAEKKV---QLACKERDAAKKEIKNIKEELATRL 539
+ +M +++ + K E ++ E ++KV Q +E K +++ + R+
Sbjct: 407 EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARI 466
Query: 540 NSSETADLL-KEKDEQIRGLMEEGEKLSKQQLHNSNIIKK---LRAKDKENENMVAKLNK 595
E + L K K ++++ +E+ + + ++K LR ++ + NK
Sbjct: 467 KELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNK 526
Query: 596 KVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVER-------QEKDLGRLQVDMDE 648
+++ L L+++ +E++E ++ +++ S+ E +K++ L ++
Sbjct: 527 PAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEK 586
Query: 649 LEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEAR 708
L ++N S+++ L+ A KE +D+ +K E A++ +A EEL + K
Sbjct: 587 LSKENESLKSKLEHANKENSDVIALWKSK----LETAIASHQQAMEELKVSFSKGLGTET 642
Query: 709 QQQETLAIQVGDLRLALQR----------TEQAAARKE-DYLR-----------HEIGEL 746
+ L Q+ +RL Q +E+AA KE + LR + + +
Sbjct: 643 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAI 702
Query: 747 QQRLQEAENRNQ-ELSQSVSSTTRPLLR--QIENLQATLGSQTSSWEKLEKNLSDRLGES 803
+ +L +AE+++ E+ +++ ++ ++E LQA QT K+ N + +L +
Sbjct: 703 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQT----KVIDNFTSQLKAT 758
Query: 804 QTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDEN 863
+ L +A++E K +M + Q ++ + + +E ++ + E
Sbjct: 759 EEKLLDLDALRKASSE----GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL 814
Query: 864 NRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKP 923
+++L NL++ L E + K L +L++ + K + ++A+ Q +++E K
Sbjct: 815 QGRELKLTNLQEN----LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKL 870
Query: 924 FSVSSTPTMSRSSSISGV--DMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRM-G 980
M SS + + ++A ++ F +DE + N ++ + ++M G
Sbjct: 871 HQKEEQFNML-SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN--DIAEIMKMSG 927
Query: 981 AGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLT-----NQNDELEEKV 1035
SS + + +L+L+E ++ LQL++ + S + + + +T +Q + ++
Sbjct: 928 DNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHE 987
Query: 1036 KEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLR 1089
+E +L +L DL+++ T + +EL+ E + KT+ +E+L+
Sbjct: 988 EEKKELERKLSDLEKKMET-------SHNQCQELKARYERATSETKTKHEEILQ 1034
Score = 103 bits (257), Expect = 9e-22
Identities = 195/988 (19%), Positives = 413/988 (41%), Gaps = 147/988 (14%)
Query: 146 ETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEETVNKESDMKVPTVSLKVSESVIDVKT 205
E + +V+D V E++ G +T+ +H KE + + K + +++
Sbjct: 432 EEEKRKVEDLQFRVEEESITKGDLETQTKLEHARI--KELEQSLLFEKTKADKLQRELED 489
Query: 206 TMESISNTSTQSLTAETKDIALEPKEQKHEDR--QSNTPSPPVSTFSSGTSTTSDI-EVL 262
T + + ++ + E KD+AL +E R +SN P+ V S S + E L
Sbjct: 490 TRVATVSEKSRIMELE-KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKL 548
Query: 263 DHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDA 322
+ + +S +E ++ H Q + L Y + K ES S
Sbjct: 549 EVTRTDHQREITSLKEHFGAREETH--QKEIKAL-------YTATEKLSKENESLKS--- 596
Query: 323 FERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSSTPK-SKTVESAEGKSEEVN 381
+++ + ++ D ++ + + ++ A+ + V+ S ++T E AE K++
Sbjct: 597 --KLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEK 654
Query: 382 ETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTP--INEGQTVLDKVAEQCEPAESQPE 439
L E ++ S + ++ + L + I E + L+ + + + AE Q
Sbjct: 655 MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH- 713
Query: 440 ALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSL 499
L E ED ++ K+++ E +++ ++ DN ++ +E+ + +L
Sbjct: 714 -LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI----DNFTSQLKATEEKLLDLDAL 768
Query: 500 KDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLM 559
+ ++ +E +K Q + +AA+K+IK++ E+ SS+ + + +E + L
Sbjct: 769 RKASSEGKSEMKKLRQ----QLEAAEKQIKHL--EIEKNAESSKASSITRELQGRELKLT 822
Query: 560 EEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEK 619
E LS+ + K+L+ L +K E EE +++ + +E V K
Sbjct: 823 NLQENLSEVSQVKETLEKELQI-----------LKEKFAEASEEAVSVQRSM--QETVNK 869
Query: 620 QHR--ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAK 677
H+ E L+S +E+ ++L ++ E +E+ + A + ++ ++ K +
Sbjct: 870 LHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG-- 927
Query: 678 DSEAQEAALSREMKAKE----ELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAA 733
D+ +Q ++ E++ KE EL L KA E A Q+++ D+ + ++++Q AA
Sbjct: 928 DNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE----DMTVKAEQSQQEAA 983
Query: 734 RKEDY----LRHEIGELQQRLQEAENRNQELS----QSVSSTTRPLLRQIENLQATLGSQ 785
+K + L ++ +L+++++ + N+ QEL ++ S T ++NLQ TL
Sbjct: 984 KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDT 1043
Query: 786 TSSWEKLEKNLSDRLGESQTLLAAAVERERAATEE------------------------- 820
+ + S L E + L A + + A T E
Sbjct: 1044 EDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1103
Query: 821 -----------LLANKIQ-MSSMESQNSLLRQENSR---FQAQLESEK-------NRLCK 858
L N ++ + + LL EN + F+ ++E+ K +L
Sbjct: 1104 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSA 1163
Query: 859 LEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKE 918
L++EN + EL +DE V + ++ +E+++LN+QL +E +++++ F ++ +E
Sbjct: 1164 LQEENVKLAEELGRSRDE-VTSHQKLEEERSVLNNQL------LEMKKRESKFIKDADEE 1216
Query: 919 KERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVR 978
K S+S T + + T + +A+ +L+
Sbjct: 1217 KASLQKSISITSALLTEKDAELEKLRNEVTVLRGE-------------NASAKSLH---- 1259
Query: 979 MGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEI 1038
S+++ L+S E ++ +L+L++ E R + + T +++ + +I
Sbjct: 1260 -----SVVQTLESDKVKLELKVKNLELQL--KENKRQLSSSSGNTDTQADEDERAQESQI 1312
Query: 1039 PKLRTQLRDLDQRYNTILQMYGEKAEEA 1066
L + + DL QR N L+M E EA
Sbjct: 1313 DFLNSVIVDL-QRKNQDLKMKVEMMSEA 1339
Score = 67.0 bits (162), Expect = 9e-11
Identities = 171/823 (20%), Positives = 327/823 (39%), Gaps = 139/823 (16%)
Query: 146 ETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEETVNKESDMKVPTVSLKVSESVIDVKT 205
ET + ++K +L + E L+ S K++ +H NKE+ + K+ ++ +
Sbjct: 571 ETHQKEIK--ALYTATEKLSKENESLKSKLEH---ANKENSDVIALWKSKLETAIASHQQ 625
Query: 206 TMESISNTSTQSLTAETKDIALEPKEQKHE---DRQSNTPSPPVSTFSSGTSTTSDIEVL 262
ME + + ++ L ET + A E K Q + D Q + S + ++E L
Sbjct: 626 AMEELKVSFSKGLGTETAEFA-ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 684
Query: 263 -------------DHESVISESSASSRQETTDSKSSLHLMQTS------FQLLSASACPE 303
E++ S+ + Q + + +L+ +Q + ++L A +
Sbjct: 685 RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQ 744
Query: 304 YNRLDDF----QKLTESCCSSDAFERIDSFSVQSL-----------------------DS 336
+D+F + E DA + S + +S
Sbjct: 745 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 804
Query: 337 RSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEES 396
S I EL G+ L + N S S+ E+ E + + + E +EEA +
Sbjct: 805 SKASSITR--ELQGRELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEASEEAVSVQR 861
Query: 397 GRSATPVNCEQPDI---LVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKE----DVCK 449
T Q + ++SS + + D A+ E E + + + KE D+ +
Sbjct: 862 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 921
Query: 450 TVEFLNE------------KLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSIS 497
++ + +L++R+ + L L KA +F E VK E S
Sbjct: 922 IMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE 981
Query: 498 SLKD------EFTQRIAEAEKKVQLA---CKERDA----AKKEIKNIKEELATRLNSS-- 542
+ K E +++++ EKK++ + C+E A A E K EE+ L +
Sbjct: 982 AAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLL 1041
Query: 543 ETADLLKEKDEQIRGLMEEGEKLSKQQ--------LHNSNIIKKLRAKDK--------EN 586
+T D LK E+ GL++E E+L KQ ++ I + K+K +
Sbjct: 1042 DTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDT 1101
Query: 587 ENMVAKLNKKVKELEE-ELQHLKQVLDGKE--EVEKQHRENIKKLNSMVERQEKDLGRLQ 643
+ AKL ++ L+E L++++++ KE VE Q E +K +E ++ +
Sbjct: 1102 KQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRK---EIETLKQAAAQKS 1158
Query: 644 VDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSRE-MKAKEELSAALEK 702
+ L+E+N + L + E+T K E + + L+ + ++ K+ S ++
Sbjct: 1159 QQLSALQEENVKLAEELGRSRDEVTSHQKL------EEERSVLNNQLLEMKKRESKFIKD 1212
Query: 703 AQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQ 762
A EE Q++++I AL + A K LR+E+ L+ A++ + + Q
Sbjct: 1213 ADEEKASLQKSISI-----TSALLTEKDAELEK---LRNEVTVLRGENASAKSLH-SVVQ 1263
Query: 763 SVSSTTRPLLRQIENLQATLG------SQTSSWEKLEKNLSDRLGESQTLLAAAVERERA 816
++ S L +++NL+ L S +S + + +R ESQ +V +
Sbjct: 1264 TLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQ 1323
Query: 817 ATEELLANKIQMSSMESQNSL---LRQENSRFQAQLESEKNRL 856
+ L K++M S + N L +S Q + +K RL
Sbjct: 1324 RKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRL 1366
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 105 bits (261), Expect = 3e-22
Identities = 157/697 (22%), Positives = 301/697 (43%), Gaps = 107/697 (15%)
Query: 417 INEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLE 476
++E LDKV + +Q L + EFL +LE++EA + LS+EK+
Sbjct: 1268 LHEATAKLDKVTQLANDLAAQKTKLWSESG-----EFLR-RLEEKEALINQLSREKSNFT 1321
Query: 477 EAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELA 536
++L+ ++ ++E+ S S+L A A +K Q C +E + +K EL
Sbjct: 1322 RQIEDLRGQL---EKETKSQSAL--------AHALQKAQRDCDLLREQYEEEQEVKAELH 1370
Query: 537 TRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKK 596
L S A++++ + + +++ E L + K+L + +E + N +
Sbjct: 1371 RTL-SKVNAEMVQWRMKYENNVIQRTEDLEDAK-------KELAIRLQEAAEAMGVANAR 1422
Query: 597 VKELEEELQHLKQVL-DGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRS 655
LE L+ L D ++ K ++ + +++++ G+ D ++K+
Sbjct: 1423 NASLERARHQLQLELGDALSDLGK-----VRSAAARLDQKQLQSGKALADW---KQKHEE 1474
Query: 656 IQAALDSAYKEL----TDLHKA-NAAKDSEAQEAALSREMK-AKEELSAALEKAQE---- 705
QA LD++ KE+ T+L K N ++S + L RE K +EE+S + +E
Sbjct: 1475 SQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKN 1534
Query: 706 --EARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQS 763
E + ++ + + ++++ L+ TE A R E + H EL + E E + E +
Sbjct: 1535 LTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEE 1594
Query: 764 VSSTTRPLLRQIENLQATLGSQTSSW---EKLEKNLSDRLGESQTLLAAAVERERAATEE 820
+ + R I++LQ++L S+ S +L+K + + L E + L+ A + AT+
Sbjct: 1595 IENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKS 1654
Query: 821 LLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRT 880
L +IQ+ ++ Q Q NS + Q+ + R N+ Q ELE+L+
Sbjct: 1655 LGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERR-------NSLLQSELEDLR------ 1701
Query: 881 LEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISG 940
+ +E+T +L E + ER +TQ T ++K
Sbjct: 1702 ---SLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEA-------------- 1744
Query: 941 VDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEI 1000
D+A +Q E+ + + N + + A + NL +LK ++ I
Sbjct: 1745 -DVARMQK------EAEE-------VVQECQNAEEKAKKAAIEAA--NLSEELKKKQDTI 1788
Query: 1001 THLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYG 1060
HL+ N+E+T + + + L + + L K+I KL +++R+L+ ++
Sbjct: 1789 AHLERTRENMEQTITDLQKRLAEA--EQMALMGSRKQIQKLESRVRELEGELEGEIRRSA 1846
Query: 1061 EKAEEAEELRLDL--------EDVKNM--YKTQIDEL 1087
E A L + ED KN+ +TQ+D+L
Sbjct: 1847 EAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKL 1883
Score = 101 bits (251), Expect = 4e-21
Identities = 194/929 (20%), Positives = 362/929 (38%), Gaps = 184/929 (19%)
Query: 313 LTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVES 372
L E C F + L ++ VS ++L + A + N ++S
Sbjct: 864 LKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKS 923
Query: 373 A---EGKSEEVNETLVIPTE-EAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVA 428
E + +E++E + E +E+ GR + + I++ +T+L K
Sbjct: 924 KIQLEARVKELSERVEEEEEINSELTARGRKL------EDECFELKKEIDDLETMLVKSE 977
Query: 429 EQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFR 488
++ E + + L+E+ VEFLNE + K L++ +++EA D++
Sbjct: 978 KEKRTTEHKVKNLTEE------VEFLNEDISK-------LNRAAKVVQEAHQQTLDDLHM 1024
Query: 489 VKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSET---- 544
+E+ SS+S + Q++ E E ++ K R ++E+ ++ L S E
Sbjct: 1025 EEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESS 1084
Query: 545 ----ADLLKEKD----------EQIRGLMEEGEKLSKQ-QLHNSNIIKKLRAKDKENENM 589
A+ L++K+ E +GL+ + +K K+ Q ++ +KL A+ M
Sbjct: 1085 QRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKM 1144
Query: 590 ----------VAKLNKKVKEL------------EEELQHLKQVLDGKE----------EV 617
+A LN++++E+ ++E + K D +E +
Sbjct: 1145 ERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASL 1204
Query: 618 EKQHRENIKKLNSMVE-------RQEKDLGRLQVDMDEL--------------------- 649
+K+H +++ +L VE + EKD LQ+++D+L
Sbjct: 1205 KKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLY 1264
Query: 650 EEKNRSIQAALDSAYKELTDL------------------------------HKANAAKDS 679
EE+ A LD + DL K+N +
Sbjct: 1265 EERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQI 1324
Query: 680 EAQEAALSREMKAKEELSAALEKAQEEA---RQQQETLAIQVGDLRLALQRTE----QAA 732
E L +E K++ L+ AL+KAQ + R+Q E +L L + Q
Sbjct: 1325 EDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWR 1384
Query: 733 ARKEDYLRHEIGELQQRLQEAENRNQELSQSV---SSTTRPLLRQIENLQATLGSQTSSW 789
+ E+ + +L+ +E R QE ++++ ++ L R LQ LG S
Sbjct: 1385 MKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDL 1444
Query: 790 EKLE--------------KNLSD---RLGESQTLLAAAVERERAATEELLANKIQMSSME 832
K+ K L+D + ESQ LL A+ + +A + ELL K
Sbjct: 1445 GKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESI 1504
Query: 833 SQNSLLRQENSRFQAQLESEKNRL---CKLEDENNRYQVELENLKDEYVRTLEET----- 884
LR+EN Q ++ + N++ K E + + +E K E TLEET
Sbjct: 1505 VGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALE 1564
Query: 885 RKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMA 944
R E +L+ QLE+ K E ERK + +E + ++ ++ S SS+ +
Sbjct: 1565 RNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSL-----QSSLDSEAKS 1619
Query: 945 GLQTSFLSQDESHDHSFGPMPISANGSNLYDAVR-MGAGSSIIENLQSQLKLREGEITHL 1003
++ + L + D + + +S + +A + +G I++LQ QL + L
Sbjct: 1620 RIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDL 1679
Query: 1004 QLEIGNLEKTRSIMAEELVKLTN-----------QNDELEEKVKEIPKLRTQLRDLDQRY 1052
+ ++ E+ S++ EL L + +EL E + I TQ L +
Sbjct: 1680 KEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQK 1739
Query: 1053 NTILQMYGEKAEEAEELRLDLEDVKNMYK 1081
+ +EAEE+ + ++ + K
Sbjct: 1740 KKLEADVARMQKEAEEVVQECQNAEEKAK 1768
Score = 87.0 bits (214), Expect = 9e-17
Identities = 149/728 (20%), Positives = 308/728 (42%), Gaps = 80/728 (10%)
Query: 421 QTVLDKVAEQCEPAESQPEALS-EKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAF 479
Q L+K Q E +++ +L+ EK D+ ++ E L E Q L K K LE
Sbjct: 872 QKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARV 931
Query: 480 DNLKDEMFRVKEESSSISS----LKDE---FTQRIAEAEKKVQLACKERDAAKKEIKNIK 532
L + + +E +S +++ L+DE + I + E + + KE+ + ++KN+
Sbjct: 932 KELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLT 991
Query: 533 EELA------TRLNSS---------ETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIK 577
EE+ ++LN + +T D L ++E++ L + KL +Q ++
Sbjct: 992 EEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALE 1051
Query: 578 KLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEK 637
+ R E + KL +K E +++L+ E ++ + ++NS VE ++
Sbjct: 1052 QERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKG 1111
Query: 638 DLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELS 697
+ +LQ + EL+ + + ++ L++ E T K + Q+ A ++ + E
Sbjct: 1112 LVAQLQKTVKELQTQIKDLKEKLEA---ERTTRAKMERERADLTQDLA---DLNERLEEV 1165
Query: 698 AALEKAQEEARQQQETLAIQV-GDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENR 756
AQ E ++QET ++ D+ A E +A + + EL+ +++ +
Sbjct: 1166 GGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQV 1225
Query: 757 NQELSQSVSSTTRPLLRQIENLQATLGSQT---SSWEKLEKNLSDRLGESQTLLAAAVER 813
Q+L + S L ++++L + T ++ EKL +RL E+ A +++
Sbjct: 1226 KQKLEKDKSD----LQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEA----TAKLDK 1277
Query: 814 ERAATEELLANKIQMSS--------MESQNSLLRQ---ENSRFQAQLESEKNRLCK---- 858
+L A K ++ S +E + +L+ Q E S F Q+E + +L K
Sbjct: 1278 VTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKS 1337
Query: 859 ---LEDENNRYQVELENLKDEYVRTLE---ETRKEKTLLNSQLEMERMKVEQERKKAIFT 912
L + Q + + L+++Y E E + + +N+++ RMK E
Sbjct: 1338 QSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENN-----VI 1392
Query: 913 QETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSN 972
Q T ++ K + + ++ A L+ + + + + +
Sbjct: 1393 QRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAA 1452
Query: 973 LYDAVRMGAGSSII------ENLQSQLKLREGEITHLQLEIGNLEKT--RSIMAEELVKL 1024
D ++ +G ++ E Q+ L + E+ L E+ L+ T SI+ +E ++
Sbjct: 1453 RLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRR 1512
Query: 1025 TNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQI 1084
N+N L+E EI L Q+R+ + + ++ EE E+++ LE+ + +
Sbjct: 1513 ENKN--LQE---EISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNE 1567
Query: 1085 DELLRQSL 1092
++L L
Sbjct: 1568 SKILHFQL 1575
Score = 69.3 bits (168), Expect = 2e-11
Identities = 101/468 (21%), Positives = 202/468 (43%), Gaps = 79/468 (16%)
Query: 460 KREAQLLS--LSKEKALLEEAF---DNLKDEMFRVKEESSSISSLKDEFTQRIAEAEK-- 512
++E Q LS L K K EE+ + L+ E ++EE S++++ E T+ + E EK
Sbjct: 1483 QKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVK 1542
Query: 513 --------KVQLACKERDAA--KKEIKNIKEELATRLNSSETADLLKEKDEQIRG----- 557
+VQ+ +E + A + E K + +L +E L EKDE+I
Sbjct: 1543 KLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQ 1602
Query: 558 ------LMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKE-------LEEEL 604
L + +K ++ + + KK+ E E ++ N++V E L+ ++
Sbjct: 1603 QCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQI 1662
Query: 605 QHLKQVLDGKEEVEKQHRENI---KKLNSMVERQEKDLGRLQ--------VDMDELEE-- 651
+ L+ LD ++ +E + ++ NS+++ + +DL LQ + +EL E
Sbjct: 1663 KDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEAT 1722
Query: 652 ---------------KNRSIQAALDSAYKELTDL-----HKANAAKDSEAQEAALSREMK 691
+ + ++A + KE ++ + AK + + A LS E+K
Sbjct: 1723 ERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELK 1782
Query: 692 AKEELSAALEKAQEEARQQQETLAIQVGDL-RLALQRTEQAAARKEDYLRHEIGELQ--- 747
K++ A LE+ +E Q L ++ + ++AL + + + E +R GEL+
Sbjct: 1783 KKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEI 1842
Query: 748 QRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLE---KNLSDRLGESQ 804
+R EA+ + L + + + L Q E + L + +KL+ +N ++ ++
Sbjct: 1843 RRSAEAQRGARRLERCI----KELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAE 1898
Query: 805 TLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESE 852
T + + + EL K + ESQ + L+ + F +++ E
Sbjct: 1899 TQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
Score = 65.1 bits (157), Expect = 3e-10
Identities = 124/577 (21%), Positives = 239/577 (41%), Gaps = 97/577 (16%)
Query: 151 QVKDSSLCVSGETLAAGTSSPKTEGKHEET--VNKESDMKVPTVSLKVSESVIDVKTTME 208
+V+ ++ + + L +G + + KHEE+ + S +V +S ++ + +K T E
Sbjct: 1446 KVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTEL----LKLKNTYE 1501
Query: 209 SISNTSTQSLTAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVI 268
S ++L E K++ E ++ R+ GT +++E + + +I
Sbjct: 1502 E-SIVGQETLRRENKNLQEEISNLTNQVRE-------------GTKNLTEMEKV--KKLI 1545
Query: 269 SESSASSRQETTDSKSSLHLMQTS---FQLLSASACPEYNRLDDFQKLTESCCSSDAFER 325
E + +++ +L ++ FQL A E R KL+E + F R
Sbjct: 1546 EEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELER-----KLSEKDEEIENFRR 1600
Query: 326 IDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNET-L 384
++ SL S SE S E+ T K +E E++NE L
Sbjct: 1601 KQQCTIDSLQSSLDSEAKSRIEV---------------TRLKKKME------EDLNEMEL 1639
Query: 385 VIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEAL-SE 443
+ ++ E+ +S + + D+ + +++ + + EQ AE + L SE
Sbjct: 1640 QLSCANRQVSEATKSLGQLQIQIKDLQMQ---LDDSTQLNSDLKEQVAVAERRNSLLQSE 1696
Query: 444 KEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEF 503
ED+ E E +LL ++ L +L + +++ + + + +E
Sbjct: 1697 LEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEV 1756
Query: 504 TQRIAEAEKKVQLACKERDAAKKEIKNIKEELA----TRLNSSETADLLKEKDEQIRGLM 559
Q AE+K + A E +E+K ++ +A TR N +T L+++ +
Sbjct: 1757 VQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKR-------L 1809
Query: 560 EEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEK 619
E E+++ + + I+KL ++ +E E ELE E++ + G +E+
Sbjct: 1810 AEAEQMAL--MGSRKQIQKLESRVRELEG----------ELEGEIRRSAEAQRGARRLER 1857
Query: 620 QHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALD----------SAYKELTD 669
IK+L E +K+L R+Q MD+L+ K ++ + ++ S YK+
Sbjct: 1858 C----IKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKK--Q 1911
Query: 670 LHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEE 706
H+ N K E E A S+ K K + +K QEE
Sbjct: 1912 QHELNEVK--ERAEVAESQVNKLKIKAREFGKKVQEE 1946
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 105 bits (261), Expect = 3e-22
Identities = 206/1078 (19%), Positives = 434/1078 (40%), Gaps = 152/1078 (14%)
Query: 126 EEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEETVNKES 185
E++ K L E+ + Q + E+Q DSSL L+ T + + K E + +
Sbjct: 830 EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQ--ELQEKTREVQERLN 887
Query: 186 DMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSNTPSPP 245
+M+ L+ +S + +++ Q E K + E + K
Sbjct: 888 EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947
Query: 246 VSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASACPEYN 305
+ SDI H++V + ++++ ++ SL Q + L + E +
Sbjct: 948 LK---------SDI----HDTV--NMNIDTQEQLRNALESLKQHQETINTLKSKISEEVS 992
Query: 306 RLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDD------ELSGKGYALVP-- 357
R ++ T + + Q L++++ + +D E K ++L+
Sbjct: 993 RNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEK 1052
Query: 358 ---------IIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEES-GRSATPVNCEQ 407
+I K+ E+ E E E ++ E + +E + ++
Sbjct: 1053 NELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE 1112
Query: 408 PDILVSSTPINEGQTVLDKVAEQCEPAESQ----PEALSEKEDVCKTVEFLNEKLEKREA 463
++ + + E + L + ++Q + + Q E +SE + +E L +L+ +E
Sbjct: 1113 GELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKEL 1172
Query: 464 QLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEF-TQR------IAEAE----- 511
L + E+ L + + +E+ + +E + L+ F T+R I E E
Sbjct: 1173 TLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQ 1232
Query: 512 -----KKVQLACKERDAAKKEIK-NIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKL 565
K + KE E++ ++ E+ A +N+ + + E+I L EE E L
Sbjct: 1233 TKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL 1292
Query: 566 SK-------QQLHNSNIIKKLRAKDKENENMVA------KLNKKVKELEEELQHL----- 607
Q+ N + ++ K++ + +LN+K +E +EE++ L
Sbjct: 1293 PNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERD 1352
Query: 608 -----KQVLDGKEEVEKQH-RENIKKLNSMVERQEKDLG--------------------- 640
K+ L+ K + K+H RE + K+ +QE+ L
Sbjct: 1353 NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPK 1412
Query: 641 -----RLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALS-REMKAKE 694
R++++M L ++ + + S KE DL + SE+ + + +E+ AK
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 695 -ELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEA 753
E L+ A ++Q+ET + +LR+ L E + + L +LQ ++QE
Sbjct: 1473 LETEEELKVAHCCLKEQEET----INELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI 1528
Query: 754 ENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKN---LSDRLGESQTLLAAA 810
+ ++ + S + + +++ + ++ S+ + +E L++RL ESQ +
Sbjct: 1529 YEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
Query: 811 VER--ERAATEELLA---NKIQMSSMESQNSLLRQENSRFQ----AQLESEKNRLCKLED 861
++ E +E L ++++ ++ E + + +Q + + ++C++E
Sbjct: 1589 IKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEH 1648
Query: 862 ENNRYQVE---LENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKE 918
+++ + LEN++ E +R + +L+ LE E V +ER +ET+K
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQ-------ILHENLE-EMRSVTKERDDLRSVEETLKV 1700
Query: 919 KERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANG-SNLYDAV 977
ER + T++R ++ + E+ D G + N SN+ +
Sbjct: 1701 -ERDQLKENLRETITRDLE-KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL 1758
Query: 978 RMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELE----- 1032
+ ++L+ Q +LR + HL+ + ++K R I++E+ KL+N +LE
Sbjct: 1759 EHSNDALKAQDLKIQEELRIAHM-HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAK 1817
Query: 1033 --EKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVK-NMYKTQIDEL 1087
EK++E+ QL L + N +K E E+L+ ++D + K +I+ L
Sbjct: 1818 LQEKIQELKANEHQLITLKKDVNET----QKKVSEMEQLKKQIKDQSLTLSKLEIENL 1871
Score = 102 bits (253), Expect = 3e-21
Identities = 175/855 (20%), Positives = 369/855 (43%), Gaps = 117/855 (13%)
Query: 303 EYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNS 362
E RL+ QKL E+ +E + S + + + + + + +GY + I +
Sbjct: 1178 ETERLELAQKLNEN------YEEVKSITKERKVLKELQKSFETERDHLRGY--IREIEAT 1229
Query: 363 STPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQT 422
+ ++ A +E ET+ +E S ++A +N + D+ S T + E
Sbjct: 1230 GLQTKEELKIAHIHLKEHQETI----DELRRSVSEKTAQIINTQ--DLEKSHTKLQEEIP 1283
Query: 423 VLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLS-LSKEKALLEEAFDN 481
VL + E + +SE ++ +E L E+ +++ L+ + E+ L E F
Sbjct: 1284 VLHEEQELLPNVKE----VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQE 1339
Query: 482 LKDEMFRVKEESSSISSLK-------DEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEE 534
++E+ + +E ++ ++K D+ + I E K+Q E + +++ N+KE+
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ----ESQSKQEQSLNMKEK 1395
Query: 535 LATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLN 594
+ K KD + + E LSK+ L S+ K AK+K++ L
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKR-LQESHDEMKSVAKEKDD------LQ 1448
Query: 595 KKVKELEEELQHLKQVLDGKEEVEK--QHRENIKKLNSMVERQEKDLGRLQVDMDELEEK 652
+ + L+ E LK+ + KE V K + E +K + ++ QE+ + L+V++ E E +
Sbjct: 1449 RLQEVLQSESDQLKENI--KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506
Query: 653 NRSIQAALDSAYKELTDL--------HKANAAKDSEAQEAA-----LSREMKAKEELSAA 699
+IQ L++ +L + + N + SE QE KAK+ +
Sbjct: 1507 ISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQS 1566
Query: 700 LEKAQEEA----RQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAEN 755
+E E ++ QE + I + + + ++R ++A + D L+ E+ +++E++
Sbjct: 1567 IESKMLELTNRLQESQEEIQIMIKE-KEEMKRVQEALQIERDQLKENTKEIVAKMKESQE 1625
Query: 756 RN-QELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERE 814
+ Q L + + T+ + +IE+L+ +Q + E +E + RL + +L +E
Sbjct: 1626 KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETE-NIRLTQ---ILHENLEEM 1681
Query: 815 RAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVE----L 870
R+ T+E + +++ + L+ EN R + EK K+ + + E L
Sbjct: 1682 RSVTKERDDLRSVEETLKVERDQLK-ENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740
Query: 871 ENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTP 930
+ E + +K+ N L+ + +K+++E + A + +E K + S
Sbjct: 1741 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK 1800
Query: 931 TMSRSSSISGVDMAGLQTSFLSQD-ESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENL 989
T S+ ++ + + Q+ ++++H + N + S +E L
Sbjct: 1801 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQ--------KKVSEMEQL 1852
Query: 990 QSQLKLREGEITHLQLE--------IGNLEKTRSIM--------AEELVKLTNQNDELEE 1033
+ Q+K + ++ L++E NLE+ +S+M EE +KL + D+L+E
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKL--ERDQLKE 1910
Query: 1034 KVKEIPKLRTQLRDLD----------------QRYNTILQMYGEKAEEAEELRLDLEDVK 1077
++E T+ RDL+ + + + + EK + +++ DL+ K
Sbjct: 1911 SLQE-----TKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSK 1965
Query: 1078 NMYKTQIDELLRQSL 1092
+ + +I EL ++ L
Sbjct: 1966 DELQKKIQELQKKEL 1980
Score = 94.7 bits (234), Expect = 4e-19
Identities = 184/940 (19%), Positives = 356/940 (37%), Gaps = 130/940 (13%)
Query: 174 EGKHEETVNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQK 233
E K + V+ E +++ + S+ID K + + N + + + KE
Sbjct: 677 EAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQ------KELN 730
Query: 234 HEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSF 293
E ++ V S S S++E L R+E D LH++ +
Sbjct: 731 KEVEENEALREEVILLSELKSLPSEVERL-------------RKEIQDKSEELHIITSEK 777
Query: 294 QLLSASACPEYNRL-----------DDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEI 342
L + + +R+ DD + S+D + +F +D ++
Sbjct: 778 DKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTD--QEFQNFKTLHMDFEQKYKM 835
Query: 343 NSDDE---------LSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEM 393
++ LS + + T S + + K+ EV E L E+ +
Sbjct: 836 VLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLN-EMEQLKE 894
Query: 394 EESGRSATPVNCEQPDILVSST---PINEGQTVLDKVAEQCEPAES-QPEALSEKEDVCK 449
+ R +T E+ L++ + E +T+ + + + ES Q E K D+
Sbjct: 895 QLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHD 954
Query: 450 TVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAE 509
TV + E+ L SL + + + + +E+ R + KDEF Q++
Sbjct: 955 TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVG 1014
Query: 510 AEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQ 569
+KK L K ++K+ + + E+ +I L++E +L QQ
Sbjct: 1015 IDKKQDLEAKNTQTLTADVKD---------------NEIIEQQRKIFSLIQEKNEL--QQ 1057
Query: 570 LHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLN 629
+ S I +K + K EN+ + E +EEL+ L L ++E+ Q + + K
Sbjct: 1058 MLESVIAEKEQLKTDLKENIEMTI-----ENQEELRLLGDELKKQQEIVAQEKNHAIKKE 1112
Query: 630 SMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSRE 689
+ R L ++ + E ++ + Q L + +E++++ K K +E + L E
Sbjct: 1113 GELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK----KINEIEN--LKNE 1166
Query: 690 MKAKEELSAALEKAQEEARQQQETLAIQVGDL---RLALQRTEQAAARKEDYLRHEIGEL 746
+K KE +E + E Q+ +V + R L+ +++ + D+LR I E+
Sbjct: 1167 LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREI 1226
Query: 747 QQ--------------RLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKL 792
+ L+E + EL +SVS T QI N Q S T E++
Sbjct: 1227 EATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKT----AQIINTQDLEKSHTKLQEEI 1282
Query: 793 -----EKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQA 847
E+ L + E E E + + ++ +E + L ++ Q
Sbjct: 1283 PVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQE 1342
Query: 848 QLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERK 907
+++S L+ +V+ + LK+ TL + ++ ++ L M+ + + E
Sbjct: 1343 EIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMK--EKDNETT 1400
Query: 908 KAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPIS 967
K + E K K+ + ++M GL ESHD +
Sbjct: 1401 KIVSEMEQFKPKDSALLRIE-------------IEMLGLSKRL---QESHDE------MK 1438
Query: 968 ANGSNLYDAVRMGAGSSIIENLQSQLK--LREGEITHLQLEIGNLEKTRSIMAEELVKLT 1025
+ D R+ ++++ QLK ++E HL+ E L+ + E+ +
Sbjct: 1439 SVAKEKDDLQRL---QEVLQSESDQLKENIKEIVAKHLETE-EELKVAHCCLKEQEETIN 1494
Query: 1026 NQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEE 1065
L EK EI ++ QL ++ + +Q EK E+
Sbjct: 1495 ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ 1534
Score = 78.2 bits (191), Expect = 4e-14
Identities = 159/841 (18%), Positives = 328/841 (39%), Gaps = 115/841 (13%)
Query: 121 KSQRPEEEVKSSLHESLHIGQSRTP-ETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEE 179
K Q +EE+KS E ++ + E Q+K+ ETLA +++ K E+
Sbjct: 1336 KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIR----ETLA---KIQESQSKQEQ 1388
Query: 180 TVN-KESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQ 238
++N KE D + + VSE ME + L E + + L + Q+ D
Sbjct: 1389 SLNMKEKDNETTKI---VSE--------MEQFKPKDSALLRIEIEMLGLSKRLQESHDEM 1437
Query: 239 SNTPSPP--VSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLL 296
+ + + SD ++ ++ I + +E + L + + L
Sbjct: 1438 KSVAKEKDDLQRLQEVLQSESD-QLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496
Query: 297 SASACPEYNRLDDFQKLTESCCSS------DAFERIDSFSVQSLDS--RSVSEINSDDE- 347
+ + + QK E+ + +E+ + F+++ + V+E+ E
Sbjct: 1497 RVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEH 1556
Query: 348 LSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQ 407
K AL I +SK +E E E ++ E+ EM+ R + E+
Sbjct: 1557 RKAKDSALQSI-------ESKMLELTNRLQESQEEIQIMIKEKEEMK---RVQEALQIER 1606
Query: 408 PDILVSSTPINEGQTVLDKVAEQCEPAESQPE-----ALSEKEDVCKTVEFLNEKLEKRE 462
+ ++ I VA+ E E + + A++E ++ +E L E+ E ++
Sbjct: 1607 DQLKENTKEI---------VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQK 1657
Query: 463 AQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERD 522
L ++ E L + +EM V +E + S+++ + ++ ++
Sbjct: 1658 LNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL 1717
Query: 523 AAKKEIKNIKEELATRLNSSETADLLK----EKDEQIRGLMEE----GEKLSKQQLHNSN 574
++E+K + L ET D L+ EK +I + ++ + L Q L
Sbjct: 1718 EKQEELKIVHMHLKEH---QETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQE 1774
Query: 575 IIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVER 634
++ KE + + KL V E ++L ++++ L+ ++ + +K +
Sbjct: 1775 ELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLIT 1834
Query: 635 QEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKE 694
+KD+ Q + E+E+ + I+ ++ E + L++++
Sbjct: 1835 LKKDVNETQKKVSEMEQLKKQIK-------------DQSLTLSKLEIENLNLAQKLHENL 1881
Query: 695 ELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAE 754
E ++ K ++ R+ +ETL ++ L+ +LQ T+ E+QQ L+ A
Sbjct: 1882 EEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL-----------EIQQELKTAR 1930
Query: 755 NRNQELSQSVSSTTRPLLR---QIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAA- 810
++E ++V + QI ++Q L S ++L+K + + + LL
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDL---DKSKDELQKKIQELQKKELQLLRVKE 1987
Query: 811 -VERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLE---SEKNRLCKLEDENNRY 866
V E+ K Q + +R +N + +L E + K DE R
Sbjct: 1988 DVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRI 2047
Query: 867 QVELENLKDEYVRTLEE----------TRKEKTLLNSQLEMERMKVEQERKKAIFTQETI 916
+ L+ +D+++ TL E + EK LL+ + ++ E R+K +E +
Sbjct: 2048 KESLKMERDQFIATLREMIARDRQNHQVKPEKRLLS---DGQQHLTESLREKCSRIKELL 2104
Query: 917 K 917
K
Sbjct: 2105 K 2105
Score = 77.4 bits (189), Expect = 7e-14
Identities = 147/701 (20%), Positives = 279/701 (39%), Gaps = 122/701 (17%)
Query: 435 ESQPEALSEKEDVCKTVEFLNEKLEKREAQLLS---LSKEKALLEEAFDNLKDEMFRVKE 491
E SE + T++ L+E +LL+ + E L +DNL + +++
Sbjct: 460 EIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRT 519
Query: 492 ESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKK-------EIKNIK----------EE 534
E K+E ++ E + ER K EI N+K ++
Sbjct: 520 E-------KEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQD 572
Query: 535 LATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLN 594
L L+S +LL+EK++QI+ L E + Q+L N + + E+
Sbjct: 573 LENELSSK--VELLREKEDQIKKLQEY---IDSQKLENIKMDLSYSLESIEDP------- 620
Query: 595 KKVKELEEELQHLKQV-LDGKEEVEKQHRENI------KKLNSMVERQEKDLGRLQVDMD 647
K++++ L + V LD K E EN+ K+L + ++ E D+ Q ++
Sbjct: 621 ---KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLE 677
Query: 648 ELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEA 707
++ ++ L SA+ E+T L + + + +++ EL + Q+E
Sbjct: 678 AKKKMQVDLEKELQSAFNEITKL--------TSLIDGKVPKDLLCNLELEGKITDLQKEL 729
Query: 708 RQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSST 767
++ E E A R+E L E+ L ++ Q+ S+
Sbjct: 730 NKEVE----------------ENEALREEVILLSELKSLPSEVERLRKEIQDKSEE---- 769
Query: 768 TRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQ 827
L I + + L S+ E + L + +G+++ LA ++ +E K
Sbjct: 770 ----LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTL 825
Query: 828 MSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKE 887
E + ++ +EN R ++ + K + + EL E E+TR+
Sbjct: 826 HMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE---LQEKTREV 882
Query: 888 KTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGV--DMAG 945
+ LN EME++K + E + + T +T+ E+E+ + T+ +++ D+
Sbjct: 883 QERLN---EMEQLKEQLENRDS--TLQTV-EREKTLITEKLQQTLEEVKTLTQEKDDLKQ 936
Query: 946 LQTSF-LSQDESHDHSFGPMPISANGSNLYDAVRMGAGS-SIIENLQSQLKLREGEITHL 1003
LQ S + +D+ S+++D V M + + N LK + I L
Sbjct: 937 LQESLQIERDQLK-------------SDIHDTVNMNIDTQEQLRNALESLKQHQETINTL 983
Query: 1004 QLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLR------TQLRDLDQRYNTILQ 1057
+ +I E +R++ EE T DE ++K+ I K + TQ D + N I++
Sbjct: 984 KSKISE-EVSRNLHMEENTGET--KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE 1040
Query: 1058 MYGE---KAEEAEELRLDLEDV---KNMYKTQIDELLRQSL 1092
+ +E EL+ LE V K KT + E + ++
Sbjct: 1041 QQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTI 1081
Score = 75.5 bits (184), Expect = 3e-13
Identities = 193/999 (19%), Positives = 403/999 (40%), Gaps = 102/999 (10%)
Query: 128 EVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEETVNKESDM 187
E+ + L ES Q E E + +L + + L T + K +E+ KE
Sbjct: 1573 ELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK--EIVAKMKESQEKEYQF 1630
Query: 188 KVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSNTPSPPVS 247
T + E + +++ E ET++I L + HE+ +
Sbjct: 1631 LKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLT--QILHENLEEMRSVTKER 1688
Query: 248 TFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKS-SLHLM--QTSFQLLSASACPEY 304
T +E + + E+ ++ + K +HL Q + L +
Sbjct: 1689 DDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKT 1748
Query: 305 NRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSST 364
N + + QK E S+DA + D +Q + + E K +V + +
Sbjct: 1749 NEISNMQKDLEH--SNDALKAQD-LKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS 1805
Query: 365 PKSKTVESAEGKSEE------VNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPIN 418
K +E++ K +E NE +I T + ++ E+ + + + + I S ++
Sbjct: 1806 NMQKDLENSNAKLQEKIQELKANEHQLI-TLKKDVNETQKKVSEMEQLKKQIKDQSLTLS 1864
Query: 419 EGQTVLDKVAEQC-EPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEE 477
+ + +A++ E E + E++++ + E L KLE+ + + SL + KA E
Sbjct: 1865 KLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETL--KLERDQLKE-SLQETKARDLE 1921
Query: 478 AFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELAT 537
LK KE ++ L+++ +++ + + K +D +K+I+ ++++
Sbjct: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQ 1981
Query: 538 RLNSSETADLLKEKDEQIRGLME--EGEKLSKQ--QLHNSNIIKKLRAKDKENENMVAKL 593
L E ++ +K ++ L + E + LS Q ++ N + KKL + E +VAK
Sbjct: 1982 LLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLH-ESLEEIRIVAKE 2040
Query: 594 NKKVKELEEELQHLK-QVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDE-LEE 651
+++ ++E L+ + Q + E+ + R+N V+ +++ L Q + E L E
Sbjct: 2041 RDELRRIKESLKMERDQFIATLREMIARDRQN-----HQVKPEKRLLSDGQQHLTESLRE 2095
Query: 652 KNRSIQAALDSAYKELTDLHKA-NAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQ 710
K I+ L Y E+ D ++ N +E +E+ + + + +L Q +
Sbjct: 2096 KCSRIKELL-KRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTK---- 2150
Query: 711 QETLAIQVGDLRLALQRTEQAAAR---KEDYLRHEIGELQQRLQEAENRNQELSQSVSST 767
+ L A QR R K Y+ + ++++ E+ N+ +
Sbjct: 2151 ------HIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEK 2204
Query: 768 TRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERE----RAATEELLA 823
+ LL +I++LQ + L+ N + L + +L E E + +++L+
Sbjct: 2205 QKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL-HIEEILKDFSESEFPSIKTEFQQVLS 2263
Query: 824 NKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEE 883
N+ +M+ + R + + + ++ E +R+C++ + N + + N E+
Sbjct: 2264 NRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSAT 2323
Query: 884 TRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDM 943
KE EQ+ K ++KEK K F T S +S
Sbjct: 2324 ISKE--------------WEQDLK-------SLKEKNEKLFKNYQTLKTSLAS------- 2355
Query: 944 AGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHL 1003
G Q + +QD + H +++ + L +S+ E +S + +E +I +
Sbjct: 2356 -GAQVNPTTQDNKNPH------VTSRATQLTTEKIRELENSLHEAKESAMH-KESKIIKM 2407
Query: 1004 QLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQL--------RDLDQRYNTI 1055
Q E LE T I+A+ K+ N LE+ + I L+ ++ +++ +
Sbjct: 2408 QKE---LEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL 2464
Query: 1056 LQMYGEKAEEAEELRLDLEDVKNM--YKTQIDELLRQSL 1092
+++ EK + A+E ++ K Y+ ++ LLR++L
Sbjct: 2465 VKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENL 2503
Score = 34.3 bits (77), Expect = 0.66
Identities = 67/315 (21%), Positives = 127/315 (40%), Gaps = 35/315 (11%)
Query: 429 EQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFR 488
E E E E E K+++ NEKL K L + A + + K+
Sbjct: 2313 ESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNP--H 2370
Query: 489 VKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLL 548
V ++ ++ T++I E E + A + A KE K IK + + + A L
Sbjct: 2371 VTSRATQLT------TEKIRELENSLHEA--KESAMHKESKIIKMQKELEVTNDIIAKLQ 2422
Query: 549 KEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKL-------NKKVKELE 601
+ E + L + E + Q+ + + +E E++ KL K KE E
Sbjct: 2423 AKVHESNKCLEKTKETI---QVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFE 2479
Query: 602 EELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALD 661
+E+ K ++ ++EV + REN+++ +Q +D + D + N+ +
Sbjct: 2480 KEISATKATVEYQKEVIRLLRENLRR-----SQQAQDTSVISEHTDP-QPSNKPLTCGGG 2533
Query: 662 SAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDL 721
S + T KA K ++ L +E+ ++ + L K + E + L+ +V
Sbjct: 2534 SGIVQNT---KALILK---SEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTW 2587
Query: 722 RLALQRTEQAAARKE 736
+ +RT + A K+
Sbjct: 2588 K---ERTLKREAHKQ 2599
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 104 bits (260), Expect = 4e-22
Identities = 134/662 (20%), Positives = 283/662 (42%), Gaps = 98/662 (14%)
Query: 404 NCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREA 463
+C + D + S E Q + K+ E ++ +A E E CK+V EK K
Sbjct: 427 SCRETDS-IQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELE 485
Query: 464 QLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDA 523
+ ++L K +E A L+ E ++ +++ D EA+KK L + ++
Sbjct: 486 EEITLRKS---VESALRQLEREKALLQHKNAEYQRKADH------EADKKRNLE-NDVNS 535
Query: 524 AKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLM----EEGEKLSKQQLHNSNIIKKL 579
K +++++K+ S+E + L+ + ++ L+ + +L K Q +S I++L
Sbjct: 536 LKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQL 595
Query: 580 RAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDL 639
+ +++ ++ L +LE+E +L+ L+ + E I L + E+DL
Sbjct: 596 ESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDL 655
Query: 640 GRLQVDMDELEEKNRSIQAALDSAYKELTDL-----HKANAAKDSEAQEAALSREMKA-- 692
++ + ++E + R +Q KE +++ ++ + S QE A + KA
Sbjct: 656 KNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARL 715
Query: 693 --KEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRL 750
K ++ ++E+A+ EA ++ E ++ L+ ++ A ++ L ++ + QQ++
Sbjct: 716 ADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKI 775
Query: 751 QEAENRNQELSQSVSSTTRPLLRQIEN---LQATLGSQTSSWEKLEKNLSDRLGESQTLL 807
E + L++ V + T + ++ + Q L QT L ++ E Q
Sbjct: 776 NELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTL------KMSEKQ--- 826
Query: 808 AAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQ 867
+++E E+ N +E QN+ LR+E Q++ +++L E +Y
Sbjct: 827 ---LKQENNHLMEMKMN------LEKQNAELRKERQDADGQMKELQDQL-----EAEQY- 871
Query: 868 VELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVS 927
L VR L+E +EKT L +L+ ++ +++ ER E K +
Sbjct: 872 --FSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTK-------A 922
Query: 928 STPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIE 987
+ ++RS +A Q S L +++ I++
Sbjct: 923 DSEQLARS-------IAEEQYSDLEKEK-----------------------------IMK 946
Query: 988 NLQ--SQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQL 1045
L+ + + E+T I +LE+T + ++ L N+ +EL K+K++ + ++L
Sbjct: 947 ELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRL 1006
Query: 1046 RD 1047
+D
Sbjct: 1007 KD 1008
Score = 85.1 bits (209), Expect = 3e-16
Identities = 123/572 (21%), Positives = 250/572 (43%), Gaps = 73/572 (12%)
Query: 543 ETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEE 602
ET + K+E+ + + + KL + H SN ++ +++ +++ +L K KELEE
Sbjct: 430 ETDSIQSRKNEESQEIQK---KLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEE 486
Query: 603 ELQHLKQVLDGKEEVEK-----QHR--ENIKKLNSMVERQ---EKDLGRLQVDMDELEEK 652
E+ K V ++E+ QH+ E +K + +++ E D+ L+ +++L+++
Sbjct: 487 EITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKR 546
Query: 653 NRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQ- 711
N++ Q + + + L + NA +E+ AA R+ +A E S +++ + R Q
Sbjct: 547 NQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQA--ESSKQIQQLESNNRDLQD 604
Query: 712 -----ETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSS 766
ET +++ + LQ ++ R + I +LQ R+ E ++L
Sbjct: 605 KNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLE---EDLKNG--- 658
Query: 767 TTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERA---ATEELLA 823
+ LL ++E + L + + EK + N+ + ++ ++E+E A AT+ LA
Sbjct: 659 --KILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLA 716
Query: 824 --NKIQMSSMESQNSLLRQENSRFQAQL---ESEKNRLCKLEDENNRYQVELENLKDEYV 878
NKI S E+++ +++ + + + +N L + E + +L+ + +
Sbjct: 717 DKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQK-- 774
Query: 879 RTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSI 938
+ E K+K +LN + +K+EQE +K TQ +K + ++
Sbjct: 775 --INELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQ---------------- 816
Query: 939 SGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREG 998
V+ + L Q+ +H M ++ N ++ LQ QL+ +
Sbjct: 817 --VNTLKMSEKQLKQENNH---LMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQY 871
Query: 999 EITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQM 1058
T + ++ L+ EE + T EL++K +E+ R L Q T+ +
Sbjct: 872 FSTLYKTQVRELK-------EECEEKTKLGKELQQKKQELQDERDSL--AAQLEITLTKA 922
Query: 1059 YGEKAEE--AEELRLDLEDVKNMYKTQIDELL 1088
E+ AEE DLE K M + +I E++
Sbjct: 923 DSEQLARSIAEEQYSDLEKEKIMKELEIKEMM 954
Score = 74.3 bits (181), Expect = 6e-13
Identities = 98/477 (20%), Positives = 212/477 (44%), Gaps = 50/477 (10%)
Query: 454 LNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKK 513
L E L+ + L + EK L+E F +L+ E K + + + Q+ E E+
Sbjct: 651 LEEDLKNGKILLAKVELEKRQLQERFTDLEKE----KSNMEIDMTYQLKVIQQSLEQEEA 706
Query: 514 VQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKD--EQIRGLMEEGEK------- 564
A K R A K +I EE + LL+E+ +++ L+ E EK
Sbjct: 707 EHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDC 766
Query: 565 -LSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKE---LEEELQHLKQVLDGKEEVEKQ 620
L + Q + ++K+ +++ N+ K+ ++ ++ + +L+ Q ++ + EKQ
Sbjct: 767 DLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQ 826
Query: 621 HRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSE 680
++ L M EK L+ + + + + + +Q L+ A + + L+K
Sbjct: 827 LKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLE-AEQYFSTLYKT------- 878
Query: 681 AQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAAR--KEDY 738
Q L E + K +L L++ ++E + ++++LA Q+ ++ L +EQ A +E Y
Sbjct: 879 -QVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQL-EITLTKADSEQLARSIAEEQY 936
Query: 739 LRHEIGELQQRLQEAE---NRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKN 795
E ++ + L+ E QEL++ ++ + +E TL S ++ ++
Sbjct: 937 SDLEKEKIMKELEIKEMMARHKQELTEKDAT-----IASLEETNRTLTSDVANLANEKEE 991
Query: 796 LSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNR 855
L+++L + Q L+ + E +A A K Q L+ + A++ + K
Sbjct: 992 LNNKLKDVQEQLSRLKDEEISAA----AIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEP 1047
Query: 856 LCKLED--------ENNRYQVELENLKDEYVRTLEETRKEKTLLNSQL-EMERMKVE 903
+ + D EN + +EL++ +++ + + + +KE + +Q+ E ++++E
Sbjct: 1048 VKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIE 1104
Score = 58.9 bits (141), Expect = 3e-08
Identities = 70/290 (24%), Positives = 134/290 (46%), Gaps = 29/290 (10%)
Query: 458 LEKREAQLLSLSKEK-ALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIA---EAEKK 513
LEK+ A+L ++ ++E D L+ E + + + LK+E ++ E ++K
Sbjct: 841 LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK 900
Query: 514 VQLACKERD--AAKKEIKNIK---EELATRLNSSETADLLKE---KDEQIRGLM-EEGEK 564
Q ERD AA+ EI K E+LA + + +DL KE K+ +I+ +M ++
Sbjct: 901 KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE 960
Query: 565 LSKQQLHNSNIIKKLRAKDKENENMV---AKLNKKVKELEEELQHLK----QVLDGKEEV 617
L+++ +++ + R + N+ +LN K+K+++E+L LK K +
Sbjct: 961 LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQF 1020
Query: 618 EKQ-------HRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDL 670
EKQ + + KL ++ R+E D+ E++NR + L S ++LT
Sbjct: 1021 EKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQ- 1079
Query: 671 HKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETL-AIQVG 719
K+ +A ++ E + + EL L+ + Q + L A+ +G
Sbjct: 1080 QMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIG 1129
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 104 bits (259), Expect = 5e-22
Identities = 152/691 (21%), Positives = 285/691 (41%), Gaps = 123/691 (17%)
Query: 454 LNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKK 513
LN ++E +A L K+ L+ + L++E+ + + + L+ + ++ + E ++
Sbjct: 1090 LNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1149
Query: 514 VQLAC----------KERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGE 563
++ A K+R+A ++++ EE AT + + A L K+ + + L E
Sbjct: 1150 LEEAGGATSVQIEMNKKREAEFQKMRRDLEE-ATLQHEATAAALRKKHADSVAELGE--- 1205
Query: 564 KLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRE 623
Q+ N +K+ K+K + EL++ +++Q++ K +EK R
Sbjct: 1206 -----QIDNLQRVKQKLEKEKSEFKL---------ELDDVTSNMEQIIKAKANLEKMCRT 1251
Query: 624 NIKKLN---SMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSE 680
++N S E ++ + L +L+ +N + LD ++ L + +
Sbjct: 1252 LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1311
Query: 681 AQEAA--LSREMKAKEELSAALEKAQEEA---RQQQETLAIQVGDLRLALQRT------- 728
++ L E+KAK L+ AL+ A+ + R+Q E +L+ L +
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1371
Query: 729 ----EQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSS---TTRPLLRQIENLQ-- 779
E A ++ + L +L QRLQEAE + ++ SS T L +IE+L
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD 1431
Query: 780 --------ATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKI----- 826
A L + +++K+ + ESQ+ L ++ + R+ + EL K
Sbjct: 1432 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEES 1491
Query: 827 --QMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQ---VELENLKDEYVRTL 881
+ + + +N L++E S QL S + +LE + + +EL++ +E +L
Sbjct: 1492 LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL 1551
Query: 882 EETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGV 941
E +E +L +QLE ++K E ERK A +E + K V S T + + S
Sbjct: 1552 EH--EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS-- 1607
Query: 942 DMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGA-GSSIIENLQSQLKLREGEI 1000
+ L + + M I + +N RM A +++LQS LK
Sbjct: 1608 -----RNEALRVKKKMEGDLNEMEIQLSHAN-----RMAAEAQKQVKSLQSLLK-----D 1652
Query: 1001 THLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYG 1060
T +QL+ ND+L+E + + +R N +LQ
Sbjct: 1653 TQIQLD----------------DAVRANDDLKENIAIV-----------ERRNNLLQ--- 1682
Query: 1061 EKAEEAEELRLDLEDVKNMYKTQIDELLRQS 1091
E EELR +E + K EL+ S
Sbjct: 1683 ---AELEELRAVVEQTERSRKLAEQELIETS 1710
Score = 96.7 bits (239), Expect = 1e-19
Identities = 147/695 (21%), Positives = 287/695 (41%), Gaps = 98/695 (14%)
Query: 457 KLEKREAQLLSLSKEKALLEEAFDN-------LKDEMFRVKEESSSISSLKDEFTQRIAE 509
K +RE ++ S+ +E L+EA + L+++M + +E + + +A+
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900
Query: 510 AEKKVQLACKERDAAKKEIKNIKEELATR--LNSSETADLLKEKDE--QIRGLMEEGE-- 563
AE++ K + + ++K + E L +N+ TA K +DE +++ +++ E
Sbjct: 901 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960
Query: 564 --KLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQH 621
K+ K++ N +K L + + ++AKL K+ K L+E Q L +E+
Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1020
Query: 622 RENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEA 681
+ KL V+ E L + + +LE R ++ L + + DL D
Sbjct: 1021 TKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERL 1080
Query: 682 QEA-----ALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARK- 735
++ AL+ ++ ++ L + L+K +E + + E L + L +RT +A K
Sbjct: 1081 KKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL-----EEELEAERTARAKVEKL 1135
Query: 736 EDYLRHEIGELQQRLQEA------------------ENRNQELSQSV---SSTTRPLLRQ 774
L E+ E+ +RL+EA + ++L ++ +T L ++
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1195
Query: 775 IENLQATLGSQTSSWEKLEKNLSDRLGE------------SQTLLAAAVERERAATEELL 822
+ A LG Q + +++++ L E Q + A A + T E
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQ 1255
Query: 823 ANKIQMSSMESQNSL---------LRQENSRFQAQLESEKNRLCKLEDENNRYQVELENL 873
N+ + + E+Q S+ L+ EN QL+ ++ + +L Y +LE+L
Sbjct: 1256 MNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDL 1315
Query: 874 KDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMS 933
K R LEE K K L L+ R + R++ + +ET + E + +S
Sbjct: 1316 K----RQLEEEVKAKNALAHALQSARHDCDLLREQ--YEEETEAKAELQ-------RVLS 1362
Query: 934 RSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVR-MGAGSSIIENLQSQ 992
+++S +T + + E + + ++ +AV + A S +E + +
Sbjct: 1363 KANSEVAQWRTKYETDAIQRTEELEEA--KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR 1420
Query: 993 LKLREGEITHLQLEI-------GNLEKTR----SIMAEELVKLTNQNDELEEKVKEIPKL 1041
L + EI L +++ L+K + I+AE K ELE KE L
Sbjct: 1421 L---QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1477
Query: 1042 RTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDV 1076
T+L L Y L+ E + L+ ++ D+
Sbjct: 1478 STELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1512
Score = 96.3 bits (238), Expect = 1e-19
Identities = 138/672 (20%), Positives = 283/672 (42%), Gaps = 66/672 (9%)
Query: 439 EALSEKEDVCKTVEF-LNE---KLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESS 494
+A + E +C+T+E +NE K E+ + + L+ ++A L+ L ++ + S
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALIS 1299
Query: 495 SISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEK-DE 553
++ K +TQ++ + +++++ K ++A +++ + + DLL+E+ +E
Sbjct: 1300 QLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHD----------CDLLREQYEE 1349
Query: 554 QIRGLMEEGEKLSKQQLHNSNIIKKLRA----KDKENENMVAKLNKKVKELEEELQHLKQ 609
+ E LSK + K + +E E KL ++++E EE ++ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 610 VLDGKEEVEKQHRENIKKLNSMVERQEKD---LGRLQVDMDEL----EEKNRSIQAALDS 662
E+ + + + I+ L VER L + Q + D++ ++K Q+ L+S
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 663 AYKEL----TDLHKA-NAAKDSEAQEAALSREMK-AKEELSAALE------KAQEEARQQ 710
+ KE T+L K NA ++S RE K +EE+S E K E +
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 711 QETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRP 770
++ L + +L+ AL+ E + +E + E Q E E + E + + R
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN 1589
Query: 771 LLRQIENLQATLGSQTSSWE---KLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQ 827
LR +++LQ +L ++T S +++K + L E + L+ A R A E
Sbjct: 1590 HLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA---NRMAAEA------- 1639
Query: 828 MSSMESQNSLLRQENSRFQAQLESE---KNRLCKLEDENNRYQVELENLKDEYVRTLEET 884
++S SLL+ + + + K + +E NN Q ELE L+ +E+T
Sbjct: 1640 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR----AVVEQT 1695
Query: 885 RKEKTLLNSQL--EMERMKVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVD 942
+ + L +L ER+++ + ++ Q+ + + + +
Sbjct: 1696 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKA 1755
Query: 943 MAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAV-----RMGAGSSI-IENLQSQLKLR 996
+ + + +E + N+ + R+ I ++ + QL+
Sbjct: 1756 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL 1815
Query: 997 EGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTIL 1056
E + L+ E+ +K + + + K + EL + +E K +L+DL + +
Sbjct: 1816 EARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV 1875
Query: 1057 QMYGEKAEEAEE 1068
+ Y +AEEAEE
Sbjct: 1876 KAYKRQAEEAEE 1887
Score = 95.1 bits (235), Expect = 3e-19
Identities = 167/826 (20%), Positives = 344/826 (41%), Gaps = 125/826 (15%)
Query: 308 DDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSSTPKS 367
++F +L E+ S+A + L+ + VS + ++L + A + ++
Sbjct: 854 EEFTRLKEALEKSEARRK-------ELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCD 906
Query: 368 KTVESA---EGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVL 424
+ +++ E K +E+NE L E E E + + + I++ + L
Sbjct: 907 QLIKNKIQLEAKVKEMNERL-----EDEEEMNAELTAKKRKLEDECSELKRDIDDLELTL 961
Query: 425 DKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKD 484
KV ++ E++ V+ L E++ + + L+KEK L+EA D
Sbjct: 962 AKVEKEKHATENK-------------VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008
Query: 485 EMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSET 544
++ +++ ++++ K + Q++ + E ++ + + +++ K +L L ++
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLE----QEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 545 ADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEEL 604
+ + E D+Q + E+L K+ + L A+ ++ + + ++L KK+KEL+ +
Sbjct: 1065 SIMDLENDKQ-----QLDERLKKKDFE----LNALNARIEDEQALGSQLQKKLKELQARI 1115
Query: 605 QHLKQVLD----GKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAAL 660
+ L++ L+ + +VEK + ++L + ER E+ G V + E+ +K + +
Sbjct: 1116 EELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI-EMNKKREAEFQKM 1174
Query: 661 DSAYKELTDLHKANAA---KDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQ 717
+E T H+A AA K A L ++ + + LEK + E + ++
Sbjct: 1175 RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK-------LE 1227
Query: 718 VGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIEN 777
+ D+ +++ +A A E R L+ ++ E ++ +E +SV+ T Q
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKMCR----TLEDQMNEHRSKAEETQRSVNDLT----SQRAK 1279
Query: 778 LQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQN-- 835
LQ G + ++ E +S T + +R EE+ A +++S
Sbjct: 1280 LQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHD 1339
Query: 836 -SLLR---QENSRFQAQLESEKNRL--------CKLEDENNRYQVELENLKDEYVRTLEE 883
LLR +E + +A+L+ ++ K E + + ELE K + + L+E
Sbjct: 1340 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1399
Query: 884 TRK------------EKTLLNSQLEMERMKVEQERKKAI----------FTQETIKEKER 921
+ EKT Q E+E + V+ ER A F + + K++
Sbjct: 1400 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1459
Query: 922 KPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGA 981
S S + + + ++ L+ ++ +ES +H NL + +
Sbjct: 1460 YEESQSELESSQKEARSLSTELFKLKNAY---EESLEHL---ETFKRENKNLQEEI---- 1509
Query: 982 GSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKV--KEIP 1039
S + E L S K I LEK R + E ++L + +E E + +E
Sbjct: 1510 -SDLTEQLGSSGK-----------TIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGK 1557
Query: 1040 KLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQID 1085
LR QL + +Q I + EK EE E+ + + V + +T +D
Sbjct: 1558 ILRAQL-EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLD 1602
Score = 94.0 bits (232), Expect = 7e-19
Identities = 144/776 (18%), Positives = 315/776 (40%), Gaps = 82/776 (10%)
Query: 353 YALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILV 412
+ + P++ ++ K E A K E + EA +E + E+ D+ +
Sbjct: 834 FKIKPLLKSAEREK----EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889
Query: 413 SSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEK 472
+ Q L E+C+ + + K + V+ +NE+LE E L+ +K
Sbjct: 890 Q---VQAEQDNLADAEERCD------QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 940
Query: 473 ALLEEAFDNLKDE-------MFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAK 525
LE+ LK + + +V++E + + T+ +A ++ + KE+ A +
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 526 KEIKNIKEELATRLNSSETADLLKEKDEQ----IRGLMEEGEKL------SKQQLHNSNI 575
+ + ++L + T K K EQ + G +E+ +K+ +K++L
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 576 IKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQ 635
+ + D EN+ +L++++K+ + EL L ++ ++ + Q ++ +K+L + +E
Sbjct: 1061 LTQESIMDLENDKQ--QLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 636 EKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKD--SEAQEAALSREMKAK 693
E++L + ++E+ + L+ + L + A + + ++ +EA + +
Sbjct: 1119 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178
Query: 694 EELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQE- 752
EE + E R++ ++G+ LQR +Q +++ + E+ ++ +++
Sbjct: 1179 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1238
Query: 753 --AENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKN---LSDRLGESQTLL 807
A+ +++ +++ + E Q ++ TS KL+ LS +L E + L+
Sbjct: 1239 IKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALI 1298
Query: 808 AAAVERERAATEELLANKIQMSS-MESQNSLL------RQENSRFQAQLESEKNRLCKLE 860
+ + T++L K Q+ ++++N+L R + + Q E E +L+
Sbjct: 1299 SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1358
Query: 861 DENNRYQVELENLKDEY----VRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETI 916
++ E+ + +Y ++ EE + K L +L+ VE K ++T
Sbjct: 1359 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT- 1417
Query: 917 KEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDA 976
K R + S+ + + Q +F I A Y
Sbjct: 1418 --KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK-------------ILAEWKQKY-- 1460
Query: 977 VRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVK 1036
E QS+L+ + E L E+ L+ E L +N L+E
Sbjct: 1461 ----------EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE--- 1507
Query: 1037 EIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQSL 1092
EI L QL + + + ++ + E EL+ LE+ + + + ++LR L
Sbjct: 1508 EISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1563
Score = 87.0 bits (214), Expect = 9e-17
Identities = 109/550 (19%), Positives = 247/550 (44%), Gaps = 66/550 (12%)
Query: 434 AESQPEALSE-KEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEE 492
A + E L E K+ + + ++ E +E A+ SL K K L+ ++L ++ R
Sbjct: 1379 AIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1438
Query: 493 SSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNS-SETADLLKEK 551
++++ + F + +AE ++K + + E ++++KE +++ EL N+ E+ + L+
Sbjct: 1439 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF 1498
Query: 552 DEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQH----- 606
+ + L EE L++Q + I +L K+ E +L ++E E L+H
Sbjct: 1499 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI 1558
Query: 607 ---------LKQVLDGK-----EEVEKQHRENIKKLNSM-----------------VERQ 635
+K ++ K EE+E+ R +++ ++S+ ++
Sbjct: 1559 LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKM 1618
Query: 636 EKDLGRLQVDMD-------ELEEKNRSIQAALDSAYKELTDLHKAN-AAKDSEAQEAALS 687
E DL +++ + E +++ +S+Q+ L +L D +AN K++ A +
Sbjct: 1619 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN 1678
Query: 688 REMKAK-EELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGEL 746
++A+ EEL A +E+ E +R+ E I+ + L + ++ + ++ +L
Sbjct: 1679 NLLQAELEELRAVVEQT-ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQL 1737
Query: 747 QQRLQEA--ENRNQELSQSVSSTTRPL----LRQIENLQATLGSQTSSWEKLEKNLSDRL 800
Q ++EA E RN E + T + L++ ++ A L + E+ K+L RL
Sbjct: 1738 QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1797
Query: 801 GESQTLLAAAVERERAATE---ELLANKIQMSSMESQNSL--LRQENSRFQA---QLESE 852
E++ + +++ E L N+++ + S+ +R+ R + Q E +
Sbjct: 1798 DEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEED 1857
Query: 853 KNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFT 912
+ L +L+D ++ Q++++ Y R EE ++ S+ + ++++ ++A
Sbjct: 1858 RKNLLRLQDLVDKLQLKVK----AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIA 1913
Query: 913 QETIKEKERK 922
+ + + K
Sbjct: 1914 ESQVNKLRAK 1923
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 103 bits (258), Expect = 7e-22
Identities = 164/797 (20%), Positives = 343/797 (43%), Gaps = 94/797 (11%)
Query: 362 SSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQP---------DILV 412
++T ++ AE + EEV + T E E + + V E D LV
Sbjct: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 413 SSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEK 472
S + Q ++ + + + + + +D+ + E L ++++ +Q+ + +
Sbjct: 542 SKQQLE--QRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSAS 599
Query: 473 ALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAE-------------KKVQLACK 519
L EE + ++ ++K+ S++S +D T + E + +K+Q
Sbjct: 600 VLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALAN 659
Query: 520 ERDAAKKEIKNIKEELATRLNSSETADLLKEK-DEQIRGLMEEGEKLSKQQLHNSNIIKK 578
E+ AA E++ +++ + + + LL+E+ +I MEE + L+ Q + ++K
Sbjct: 660 EQAAAAHELEKMQQSVYVK---DDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
Query: 579 LRA--KDKENENMVAKLNKKVKELEEELQHLKQVLD-GKEEVEKQHRE--NIKKLNSMVE 633
L+ ++ N+++V ++ K ++E +E+L+ ++++L+ G +V + E I+ NS +
Sbjct: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 634 RQEKDLGRLQ---VDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAA--LSR 688
++ +DL Q V L E+ + + D K + +L +A K + ++ L +
Sbjct: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Query: 689 EMKA-KEEL-SAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGEL 746
E+KA KEE+ + LEKAQ Q ++ +V +L+ L+ E+ + L + +L
Sbjct: 837 EIKALKEEIGNVQLEKAQ------QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL 890
Query: 747 QQR---LQEAENRNQELSQSVSSTTRPLLR------QIENLQATLGSQTSSWEKLEKNLS 797
LQ+ + N+ L V + L+ Q E L+ L + + ++LE L
Sbjct: 891 ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 798 DRLGE--SQTLLAAAVERE----RAATEELLANKIQMSSMESQNSLLRQENSRFQAQLES 851
+R + S+T L V+ E ++ E+L Q +S + L + S + ++
Sbjct: 951 ERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISG 1010
Query: 852 EKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIF 911
N L L+D + + +L+++ +E + +L ++ K +ER++ +
Sbjct: 1011 LWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVN----KTSKERQQQVE 1066
Query: 912 TQET-IKEKERKPFSVSSTPT-MSRSSSISGVD------MAG---------LQTSFLSQD 954
E KE +K F S P+ +S + G + MAG L+ D
Sbjct: 1067 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1126
Query: 955 ESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGE----ITHLQLEIGNL 1010
E H + Y +V + I++ LQ ++ E + + I +
Sbjct: 1127 EMHT-------LLQLECEKYKSV-LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM 1178
Query: 1011 EKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELR 1070
+ + + +EL +L ++N ++E +E L +L + +T + E + EL+
Sbjct: 1179 QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQ 1238
Query: 1071 LDLEDVKNMYKTQIDEL 1087
L+D + Q +EL
Sbjct: 1239 KKLDDSYSEAVRQNEEL 1255
Score = 94.7 bits (234), Expect = 4e-19
Identities = 160/737 (21%), Positives = 306/737 (41%), Gaps = 106/737 (14%)
Query: 265 ESVISESS--ASSRQETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDA 322
+S+ SE S +E D ++ L++ Q L A A + + +K+ +S D
Sbjct: 621 DSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDD 680
Query: 323 FERIDSFSVQSLDSRSVSE--INSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEV 380
R+ +Q S + E I +D + K + S P VE E +E
Sbjct: 681 KIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK 740
Query: 381 NETLVIPTEEAEMEESGRSATPVNCEQPDIL--VSSTPINEGQTVLDKVAEQCEPA---E 435
+E L T E E+ E+G E+ + + +S+ E Q + K +Q A E
Sbjct: 741 DEKL--KTVE-ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797
Query: 436 SQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSS 495
+ + EK+ K+VE E EA+LL ++ + E+ +LK E+ +KEE +
Sbjct: 798 ELKKVIHEKDGKIKSVE------ELLEAELLKVANK----EKTVQDLKQEIKALKEEIGN 847
Query: 496 ISSLKDE---FTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKD 552
+ K + T ++ E + ++ ++ + K ++ +++LA N+ + L+E++
Sbjct: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA---NTGKWLQDLQEEN 904
Query: 553 EQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLD 612
E ++ ++E + + ++ +++ ++L KE EN + +L +KE E +L Q+L
Sbjct: 905 ESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQ 964
Query: 613 G--------KEEVEKQHRENIKKLNS---------MVERQEKDLGRLQVDMD-------- 647
K ++E+ ++N ++ +S ++ +EK++ L ++D
Sbjct: 965 DVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEH 1024
Query: 648 ------ELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALE 701
+L EKN AL S K L D K N E Q+ + E++AKE L
Sbjct: 1025 QRKKNNDLREKNWEAMEALASTEKMLQD--KVNKT-SKERQQQVEAVELEAKEVLKKLFP 1081
Query: 702 KAQEEA------------RQQQETLAIQVGDLRL-ALQRTEQAAARKEDYLRHEIGELQQ 748
K + ++ +E +A G + L+ + A L+ E + +
Sbjct: 1082 KVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS 1141
Query: 749 RLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLA 808
L E E Q+L +SV +++ T+ SS+ E+ L
Sbjct: 1142 VLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL------------ 1189
Query: 809 AAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQV 868
ER R+ +++ + + +E + E S + ++ K+ L +L Q
Sbjct: 1190 ---ERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTEL-------QK 1239
Query: 869 ELENLKDEYVRTLEETRKEKTLLNSQL------EMERMKVEQERKKAIFTQETIKEKERK 922
+L++ E VR EE K LN L + ER KV + KA Q++++ + K
Sbjct: 1240 KLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKA---QQSLELIQSK 1296
Query: 923 PFSVSSTPTMSRSSSIS 939
+ T+ +S +S
Sbjct: 1297 IVKAAGDTTVIENSDVS 1313
Score = 92.4 bits (228), Expect = 2e-18
Identities = 153/816 (18%), Positives = 344/816 (42%), Gaps = 102/816 (12%)
Query: 334 LDSRSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEM 393
+D R V ++ D++ G I S T K KT E + + L+
Sbjct: 246 VDKREVIDLLKPDQVEG--------IQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFS 297
Query: 394 EESGRSATPVNCEQPDIL---VSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCK- 449
E+ + E+ ++ + + E T++ ++ E+ + + E + +D CK
Sbjct: 298 EDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ 357
Query: 450 -TVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIA 508
T E + EK +R +++ K++ E N+ V + + +K F Q
Sbjct: 358 LTQEMMTEK--ERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK--FQQVRE 413
Query: 509 EAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQ 568
+ E ++ +E + + N +L ++ S+E L ++ + L E+ KL ++
Sbjct: 414 QMEAEIAHLKQENGILRDAVSNTTNQLESK-QSAELNKLRQDYARLVNELTEKTGKLQQE 472
Query: 569 QLHNSNIIK-------KLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKE-EVEKQ 620
++ N + +L+ ++ E + + + K+ E E Q L+ KE EV+
Sbjct: 473 EVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL 532
Query: 621 H----------RENIKKLNSMVERQEKDLGR---LQVDMDELEEKNRSIQAALDSAYKEL 667
H ++ ++L ++E ++K + + LQ+ + ++ E+N +++A + + ++
Sbjct: 533 HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 668 T----------DLHKANAAKDSEAQ--EAALSRE---MKAKEELSAALEKAQ---EEARQ 709
+LHK A KD + + E +L+ E + +KEE ++ + Q
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 710 QQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTR 769
+ + LA + L++ +Q+ K+D +R L+++LQ + E + ++ +
Sbjct: 653 KLQALANEQAAAAHELEKMQQSVYVKDDKIR----LLEEQLQHEISNKMEEFKILNDQNK 708
Query: 770 PLLRQIENLQATLGSQTSS--WEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQ 827
L +++ LQ + Q + E++EK + ++ E+ + E L IQ
Sbjct: 709 ALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK-----------DEKLKTVEELLETGLIQ 757
Query: 828 MSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENL------KDEYVRTL 881
+++ E + + +R ENS +++ K + +++ + +E L KD ++++
Sbjct: 758 VATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFASLVEELKKVIHEKDGKIKSV 813
Query: 882 EE---------TRKEKTLLNSQLEMERMKVE---QERKKAIFTQETIKEKERKPFSVSST 929
EE KEKT+ + + E++ +K E + +KA T K +E +
Sbjct: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873
Query: 930 PTMSRSSSISGVDMAGLQTS--FLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIE 987
M+ ++ L + +L + + S NL +A + +S E
Sbjct: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA----SSASQFE 929
Query: 988 NLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRD 1047
L+ LK +E E+ L+ + E S + L + ++N + +++++ + Q
Sbjct: 930 ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS 989
Query: 1048 LDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQ 1083
+ +L++ E+ +E L +L+ +K+ + Q
Sbjct: 990 SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 103 bits (258), Expect = 7e-22
Identities = 164/797 (20%), Positives = 343/797 (43%), Gaps = 94/797 (11%)
Query: 362 SSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQP---------DILV 412
++T ++ AE + EEV + T E E + + V E D LV
Sbjct: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 413 SSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEK 472
S + Q ++ + + + + + +D+ + E L ++++ +Q+ + +
Sbjct: 542 SKQQLE--QRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSAS 599
Query: 473 ALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAE-------------KKVQLACK 519
L EE + ++ ++K+ S++S +D T + E + +K+Q
Sbjct: 600 VLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALAN 659
Query: 520 ERDAAKKEIKNIKEELATRLNSSETADLLKEK-DEQIRGLMEEGEKLSKQQLHNSNIIKK 578
E+ AA E++ +++ + + + LL+E+ +I MEE + L+ Q + ++K
Sbjct: 660 EQAAAAHELEKMQQSVYVK---DDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
Query: 579 LRA--KDKENENMVAKLNKKVKELEEELQHLKQVLD-GKEEVEKQHRE--NIKKLNSMVE 633
L+ ++ N+++V ++ K ++E +E+L+ ++++L+ G +V + E I+ NS +
Sbjct: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 634 RQEKDLGRLQ---VDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAA--LSR 688
++ +DL Q V L E+ + + D K + +L +A K + ++ L +
Sbjct: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Query: 689 EMKA-KEEL-SAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGEL 746
E+KA KEE+ + LEKAQ Q ++ +V +L+ L+ E+ + L + +L
Sbjct: 837 EIKALKEEIGNVQLEKAQ------QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL 890
Query: 747 QQR---LQEAENRNQELSQSVSSTTRPLLR------QIENLQATLGSQTSSWEKLEKNLS 797
LQ+ + N+ L V + L+ Q E L+ L + + ++LE L
Sbjct: 891 ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 798 DRLGE--SQTLLAAAVERE----RAATEELLANKIQMSSMESQNSLLRQENSRFQAQLES 851
+R + S+T L V+ E ++ E+L Q +S + L + S + ++
Sbjct: 951 ERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISG 1010
Query: 852 EKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIF 911
N L L+D + + +L+++ +E + +L ++ K +ER++ +
Sbjct: 1011 LWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVN----KTSKERQQQVE 1066
Query: 912 TQET-IKEKERKPFSVSSTPT-MSRSSSISGVD------MAG---------LQTSFLSQD 954
E KE +K F S P+ +S + G + MAG L+ D
Sbjct: 1067 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1126
Query: 955 ESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGE----ITHLQLEIGNL 1010
E H + Y +V + I++ LQ ++ E + + I +
Sbjct: 1127 EMHT-------LLQLECEKYKSV-LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM 1178
Query: 1011 EKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELR 1070
+ + + +EL +L ++N ++E +E L +L + +T + E + EL+
Sbjct: 1179 QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQ 1238
Query: 1071 LDLEDVKNMYKTQIDEL 1087
L+D + Q +EL
Sbjct: 1239 KKLDDSYSEAVRQNEEL 1255
Score = 94.7 bits (234), Expect = 4e-19
Identities = 160/737 (21%), Positives = 306/737 (41%), Gaps = 106/737 (14%)
Query: 265 ESVISESS--ASSRQETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDA 322
+S+ SE S +E D ++ L++ Q L A A + + +K+ +S D
Sbjct: 621 DSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDD 680
Query: 323 FERIDSFSVQSLDSRSVSE--INSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEV 380
R+ +Q S + E I +D + K + S P VE E +E
Sbjct: 681 KIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK 740
Query: 381 NETLVIPTEEAEMEESGRSATPVNCEQPDIL--VSSTPINEGQTVLDKVAEQCEPA---E 435
+E L T E E+ E+G E+ + + +S+ E Q + K +Q A E
Sbjct: 741 DEKL--KTVE-ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797
Query: 436 SQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSS 495
+ + EK+ K+VE E EA+LL ++ + E+ +LK E+ +KEE +
Sbjct: 798 ELKKVIHEKDGKIKSVE------ELLEAELLKVANK----EKTVQDLKQEIKALKEEIGN 847
Query: 496 ISSLKDE---FTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKD 552
+ K + T ++ E + ++ ++ + K ++ +++LA N+ + L+E++
Sbjct: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA---NTGKWLQDLQEEN 904
Query: 553 EQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLD 612
E ++ ++E + + ++ +++ ++L KE EN + +L +KE E +L Q+L
Sbjct: 905 ESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQ 964
Query: 613 G--------KEEVEKQHRENIKKLNS---------MVERQEKDLGRLQVDMD-------- 647
K ++E+ ++N ++ +S ++ +EK++ L ++D
Sbjct: 965 DVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEH 1024
Query: 648 ------ELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALE 701
+L EKN AL S K L D K N E Q+ + E++AKE L
Sbjct: 1025 QRKKNNDLREKNWEAMEALASTEKMLQD--KVNKT-SKERQQQVEAVELEAKEVLKKLFP 1081
Query: 702 KAQEEA------------RQQQETLAIQVGDLRL-ALQRTEQAAARKEDYLRHEIGELQQ 748
K + ++ +E +A G + L+ + A L+ E + +
Sbjct: 1082 KVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS 1141
Query: 749 RLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLA 808
L E E Q+L +SV +++ T+ SS+ E+ L
Sbjct: 1142 VLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL------------ 1189
Query: 809 AAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQV 868
ER R+ +++ + + +E + E S + ++ K+ L +L Q
Sbjct: 1190 ---ERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTEL-------QK 1239
Query: 869 ELENLKDEYVRTLEETRKEKTLLNSQL------EMERMKVEQERKKAIFTQETIKEKERK 922
+L++ E VR EE K LN L + ER KV + KA Q++++ + K
Sbjct: 1240 KLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKA---QQSLELIQSK 1296
Query: 923 PFSVSSTPTMSRSSSIS 939
+ T+ +S +S
Sbjct: 1297 IVKAAGDTTVIENSDVS 1313
Score = 92.4 bits (228), Expect = 2e-18
Identities = 153/816 (18%), Positives = 344/816 (42%), Gaps = 102/816 (12%)
Query: 334 LDSRSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEM 393
+D R V ++ D++ G I S T K KT E + + L+
Sbjct: 246 VDKREVIDLLKPDQVEG--------IQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFS 297
Query: 394 EESGRSATPVNCEQPDIL---VSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCK- 449
E+ + E+ ++ + + E T++ ++ E+ + + E + +D CK
Sbjct: 298 EDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ 357
Query: 450 -TVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIA 508
T E + EK +R +++ K++ E N+ V + + +K F Q
Sbjct: 358 LTQEMMTEK--ERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK--FQQVRE 413
Query: 509 EAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQ 568
+ E ++ +E + + N +L ++ S+E L ++ + L E+ KL ++
Sbjct: 414 QMEAEIAHLKQENGILRDAVSNTTNQLESK-QSAELNKLRQDYARLVNELTEKTGKLQQE 472
Query: 569 QLHNSNIIK-------KLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKE-EVEKQ 620
++ N + +L+ ++ E + + + K+ E E Q L+ KE EV+
Sbjct: 473 EVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL 532
Query: 621 H----------RENIKKLNSMVERQEKDLGR---LQVDMDELEEKNRSIQAALDSAYKEL 667
H ++ ++L ++E ++K + + LQ+ + ++ E+N +++A + + ++
Sbjct: 533 HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 668 T----------DLHKANAAKDSEAQ--EAALSRE---MKAKEELSAALEKAQ---EEARQ 709
+LHK A KD + + E +L+ E + +KEE ++ + Q
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 710 QQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTR 769
+ + LA + L++ +Q+ K+D +R L+++LQ + E + ++ +
Sbjct: 653 KLQALANEQAAAAHELEKMQQSVYVKDDKIR----LLEEQLQHEISNKMEEFKILNDQNK 708
Query: 770 PLLRQIENLQATLGSQTSS--WEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQ 827
L +++ LQ + Q + E++EK + ++ E+ + E L IQ
Sbjct: 709 ALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK-----------DEKLKTVEELLETGLIQ 757
Query: 828 MSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENL------KDEYVRTL 881
+++ E + + +R ENS +++ K + +++ + +E L KD ++++
Sbjct: 758 VATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFASLVEELKKVIHEKDGKIKSV 813
Query: 882 EE---------TRKEKTLLNSQLEMERMKVE---QERKKAIFTQETIKEKERKPFSVSST 929
EE KEKT+ + + E++ +K E + +KA T K +E +
Sbjct: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873
Query: 930 PTMSRSSSISGVDMAGLQTS--FLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIE 987
M+ ++ L + +L + + S NL +A + +S E
Sbjct: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA----SSASQFE 929
Query: 988 NLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRD 1047
L+ LK +E E+ L+ + E S + L + ++N + +++++ + Q
Sbjct: 930 ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS 989
Query: 1048 LDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQ 1083
+ +L++ E+ +E L +L+ +K+ + Q
Sbjct: 990 SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.121 0.310
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,010,216
Number of Sequences: 37866
Number of extensions: 1730610
Number of successful extensions: 24373
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 542
Number of HSP's successfully gapped in prelim test: 1509
Number of HSP's that attempted gapping in prelim test: 8558
Number of HSP's gapped (non-prelim): 7878
length of query: 1093
length of database: 18,247,518
effective HSP length: 113
effective length of query: 980
effective length of database: 13,968,660
effective search space: 13689286800
effective search space used: 13689286800
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.