Guide to the Human Genome
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Search of human proteins with 110347425

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110347425 structural maintenance of chromosomes 2 [Homo
sapiens]
         (1197 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]  2311   0.0  
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]  2311   0.0  
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]  2311   0.0  
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]     316   7e-86
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]   283   7e-76
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ...   232   1e-60
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ...   232   1e-60
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ...   201   3e-51
gi|118498356 kinectin 1 isoform a [Homo sapiens]                      112   2e-24
gi|33620775 kinectin 1 isoform a [Homo sapiens]                       112   2e-24
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   111   4e-24
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   107   5e-23
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   107   5e-23
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   107   5e-23
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   107   5e-23
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   107   7e-23
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...   106   2e-22
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   106   2e-22
gi|118498362 kinectin 1 isoform b [Homo sapiens]                      105   3e-22
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   105   3e-22
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   105   3e-22
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   104   4e-22
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      104   4e-22
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   103   7e-22
gi|71061468 centromere protein E [Homo sapiens]                       103   7e-22
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   103   7e-22
gi|118498368 kinectin 1 isoform c [Homo sapiens]                      103   1e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            103   1e-21
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   103   1e-21
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    102   2e-21

>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
          Length = 1197

 Score = 2311 bits (5990), Expect = 0.0
 Identities = 1197/1197 (100%), Positives = 1197/1197 (100%)

Query: 1    MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
            MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS
Sbjct: 1    MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60

Query: 61   NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
            NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV
Sbjct: 61   NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120

Query: 121  NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180
            NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA
Sbjct: 121  NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180

Query: 181  AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
            AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL
Sbjct: 181  AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240

Query: 241  LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
            LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE
Sbjct: 241  LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300

Query: 301  DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
            DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH
Sbjct: 301  DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360

Query: 361  ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
            ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ
Sbjct: 361  ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420

Query: 421  MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
            MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE
Sbjct: 421  MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480

Query: 481  KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540
            KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA
Sbjct: 481  KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540

Query: 541  LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
            LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP
Sbjct: 541  LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600

Query: 601  DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
            DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH
Sbjct: 601  DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660

Query: 661  GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
            GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE
Sbjct: 661  GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720

Query: 721  MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
            MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM
Sbjct: 721  MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780

Query: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840
            KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL
Sbjct: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840

Query: 841  EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
            EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK
Sbjct: 841  EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900

Query: 901  EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960
            EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN
Sbjct: 901  EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960

Query: 961  NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
            NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE
Sbjct: 961  NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020

Query: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080
            DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE
Sbjct: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080

Query: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140
            NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF
Sbjct: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140

Query: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197
            IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV
Sbjct: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197


>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
          Length = 1197

 Score = 2311 bits (5990), Expect = 0.0
 Identities = 1197/1197 (100%), Positives = 1197/1197 (100%)

Query: 1    MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
            MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS
Sbjct: 1    MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60

Query: 61   NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
            NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV
Sbjct: 61   NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120

Query: 121  NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180
            NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA
Sbjct: 121  NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180

Query: 181  AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
            AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL
Sbjct: 181  AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240

Query: 241  LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
            LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE
Sbjct: 241  LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300

Query: 301  DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
            DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH
Sbjct: 301  DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360

Query: 361  ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
            ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ
Sbjct: 361  ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420

Query: 421  MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
            MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE
Sbjct: 421  MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480

Query: 481  KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540
            KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA
Sbjct: 481  KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540

Query: 541  LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
            LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP
Sbjct: 541  LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600

Query: 601  DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
            DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH
Sbjct: 601  DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660

Query: 661  GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
            GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE
Sbjct: 661  GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720

Query: 721  MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
            MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM
Sbjct: 721  MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780

Query: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840
            KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL
Sbjct: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840

Query: 841  EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
            EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK
Sbjct: 841  EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900

Query: 901  EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960
            EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN
Sbjct: 901  EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960

Query: 961  NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
            NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE
Sbjct: 961  NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020

Query: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080
            DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE
Sbjct: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080

Query: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140
            NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF
Sbjct: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140

Query: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197
            IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV
Sbjct: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197


>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
          Length = 1197

 Score = 2311 bits (5990), Expect = 0.0
 Identities = 1197/1197 (100%), Positives = 1197/1197 (100%)

Query: 1    MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
            MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS
Sbjct: 1    MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60

Query: 61   NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
            NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV
Sbjct: 61   NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120

Query: 121  NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180
            NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA
Sbjct: 121  NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180

Query: 181  AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
            AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL
Sbjct: 181  AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240

Query: 241  LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
            LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE
Sbjct: 241  LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300

Query: 301  DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
            DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH
Sbjct: 301  DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360

Query: 361  ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
            ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ
Sbjct: 361  ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420

Query: 421  MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
            MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE
Sbjct: 421  MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480

Query: 481  KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540
            KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA
Sbjct: 481  KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540

Query: 541  LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
            LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP
Sbjct: 541  LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600

Query: 601  DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
            DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH
Sbjct: 601  DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660

Query: 661  GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
            GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE
Sbjct: 661  GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720

Query: 721  MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
            MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM
Sbjct: 721  MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780

Query: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840
            KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL
Sbjct: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840

Query: 841  EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
            EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK
Sbjct: 841  EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900

Query: 901  EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960
            EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN
Sbjct: 901  EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960

Query: 961  NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
            NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE
Sbjct: 961  NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020

Query: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080
            DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE
Sbjct: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080

Query: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140
            NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF
Sbjct: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140

Query: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197
            IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV
Sbjct: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197


>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
          Length = 1217

 Score =  316 bits (810), Expect = 7e-86
 Identities = 303/1276 (23%), Positives = 585/1276 (45%), Gaps = 186/1276 (14%)

Query: 1    MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
            M+IK +I++GF+SY  +T V+ F    N I G NGSGKSN   +I F+L     S +R  
Sbjct: 1    MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLS-DEFSHLRPE 59

Query: 61   NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
                L+++     +  A V I FDNSD +       +  E    R+V+   +++Y ++  
Sbjct: 60   QRLALLHEGTGPRVISAFVEIIFDNSDNR-----LPIDKEEVSLRRVIGAKKDQYFLDKK 114

Query: 121  NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKK-- 178
                  V +L  S G + +NP++++ QG+I ++      + L ++ E AGTR+Y+ +K  
Sbjct: 115  MVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEE 174

Query: 179  -IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEH------LS 231
             I+  K  E K  K+ E+   +EE +  T+++ KEE + Y ++ K+ R +E+      L+
Sbjct: 175  SISLMKETEGKREKINELLKYIEERLH-TLEEEKEELAQYQKWDKMRRALEYTIYNQELN 233

Query: 232  RLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKE 291
                    L A+  +  S E+ ++++D     ++++ + +++++ L  +I  +++ K++ 
Sbjct: 234  ETRAKLDELSAK--RETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQ- 290

Query: 292  TGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAK--- 348
                       L+  ++   K ++  +LK K+L  E +   E  K ++++ + L  K   
Sbjct: 291  -----------LSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEE 339

Query: 349  -EKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAG------LSSNE---------- 391
             +KE+ +     ++++E   +    LA A Q    + A        +S E          
Sbjct: 340  KQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKEL 399

Query: 392  ---DGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQ 448
               D A      Q+ A   D+   +   ++   +     Q+L   +A V+++D  Y +  
Sbjct: 400  KSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYE-- 457

Query: 449  EALEAVKRLKEKLEAEMKKLNYEENKEESLL-------EKRRQLSRDIGRLKETYEALLA 501
                 VK  K++L++E   L  EEN E+  L       EK++QL R       T +A+L 
Sbjct: 458  -----VKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLR-----AATGKAILN 507

Query: 502  RFPNLRFAYKD-PEKNWNRNCVKGLVASLISVKDTSAT--TALELVAGERLYNVVVDTEV 558
               ++         K  N++   G    +++  +      T +E+ AG RL+  +VD++ 
Sbjct: 508  GIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDE 567

Query: 559  TGKKLL---ERGELKRRYTIIPLNKISARCIA-PETLRVAQNLVGPDNVHVALSLVEYKP 614
               K+L    +  L    T +PLNK+  R  A PET          ++    +S + Y P
Sbjct: 568  VSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPET----------NDAIPMISKLRYNP 617

Query: 615  ELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASI 674
               KA + VFG T +C +M+ + ++A  +      +TL GD     G L+GG      S 
Sbjct: 618  RFDKAFKHVFGKTLICRSMEVSTQLA--RAFTMDCITLEGDQVSHRGALTGGYYDTRKSR 675

Query: 675  LTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ 734
            L       ++Q ++R  E EL  LE +L            L++  E    E D L  ++Q
Sbjct: 676  L-------ELQKDVRKAEEELGELEAKLN---------ENLRRNIERINNEIDQLMNQMQ 719

Query: 735  QSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDA 794
            Q     QQ +  A + +I      +K  KE ++++E+ +   +  +++ EA     ++  
Sbjct: 720  Q--IETQQRKFKASRDSILSE---MKMLKEKRQQSEKTFMPKQRSLQSLEASLHA-MEST 773

Query: 795  QKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQI 854
            ++ L  A+   D  S+   E Q+ V+A+  E+ +L++E+       + +NE IK  E  I
Sbjct: 774  RESLK-AELGTDLLSQLSLEDQKRVDALNDEIRQLQQENR------QLLNERIK-LEGII 825

Query: 855  EVMAAEVAKN-KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKEL 913
              +   + +N ++ +++ ++E+ + +E  T   TV+ A  +E+    ++  D+  + ++L
Sbjct: 826  TRVETYLNENLRKRLDQVEQELNELRE--TEGGTVLTATTSELEAINKRVKDTMARSEDL 883

Query: 914  DHNISKHK---REAEDGAAKVSKMLKDY-DWINAE------------------------- 944
            D++I K +   +E +    +   M K++ D IN +                         
Sbjct: 884  DNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKI 943

Query: 945  RHLFGQPNSAYD-FKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMK 1003
            R L   P  A++ ++T + K+  ++L++     +K   +VN +A++      E+   L+K
Sbjct: 944  RELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYS-HVNKKALDQFVNFSEQKEKLIK 1002

Query: 1004 KKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQT 1063
            ++  ++     I+  +  L+ +K +A+ + +++V+K+F  +F  L+PG  A L   +G  
Sbjct: 1003 RQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDV 1062

Query: 1064 V-----------------------------LDGLEFKVALGNTWKE--NLTELSGGQRSL 1092
                                            G+  +V+      E   + +LSGGQ+SL
Sbjct: 1063 EGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSL 1122

Query: 1093 VALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNN 1152
            VAL+LI ++    PAP Y+ DE+D ALD  H + +  M+     H+QFI  + +  +  +
Sbjct: 1123 VALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLES 1182

Query: 1153 ANVLFKTKFVDGVSTV 1168
            A+  +  KF + VS +
Sbjct: 1183 ADKFYGVKFRNKVSHI 1198


>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
          Length = 1233

 Score =  283 bits (724), Expect = 7e-76
 Identities = 316/1265 (24%), Positives = 570/1265 (45%), Gaps = 179/1265 (14%)

Query: 3    IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
            +K I +E FKSY  R  +  F   F AI G NGSGKSN++D+I F+LG    S +R   L
Sbjct: 4    LKLIEIENFKSYKGRQIIGPFQR-FTAIIGPNGSGKSNLMDAISFVLG-EKTSNLRVKTL 61

Query: 63   QDLVYKN--GQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
            +DL++    G+    +A VS+ +            E  ++ T  R V++GG ++Y IN  
Sbjct: 62   RDLIHGAPVGKPAANRAFVSMVYSE----------EGAEDRTFAR-VIVGGSSEYKINNK 110

Query: 121  NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAA--GTRMYEYKK 178
                    +    +G+ +   +FL+ QG +  +    P E  ++ EE +  G    EY K
Sbjct: 111  VVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDK 170

Query: 179  -----IAAQKTIE-----KKEAKLKEIKTILEEEITPTIQKLKEE---RSSYLEYQKVMR 225
                 + A++  +     KK    +  +   E+E     Q+LK+E       L+  K+  
Sbjct: 171  RKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYH 230

Query: 226  ---EIEHLSRLYIAYQFLLAEDTKV--RSAEELKEMQDKVIKLQEELSENDKKIKALNHE 280
               EIE L++   +    + +D K   +  +ELKE + ++ K+  E  + +K+IK  + E
Sbjct: 231  NEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSE 290

Query: 281  IEELEKR--KDKE-TGGILRSLEDA---LAEAQRVNTKSQSAFDLKKKNLACEESKRKEL 334
            + +   +  K KE T   ++ LE A   L  AQ+   K +   D  +K +   E  R+E 
Sbjct: 291  LNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEF 350

Query: 335  EKNMVEDSKT----LAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSN 390
            E+ M E+S++    L  +E +VKK     H L+E ++K A  LA   + FN         
Sbjct: 351  EERMEEESQSQGRDLTLEENQVKKY----HRLKEEASKRAATLAQELEKFNRDQKADQDR 406

Query: 391  EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA 450
             D  E               K +TEAK     +K   +E++  Q  ++K++      +++
Sbjct: 407  LDLEER-------------KKVETEAK-----IKQKLREIEENQKRIEKLEEYITTSKQS 448

Query: 451  LEAVKRLKEKL--EAEMKKLNYEE-NKE-----ESLLEKR--RQLSRDIGRLKETYEALL 500
            LE  K+L+ +L  E EM K   +E NKE     E L + R  RQ S    R  E  E++ 
Sbjct: 449  LEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK 508

Query: 501  ARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
              +P                 V G +  L          A+  V G+ +  ++VD+E TG
Sbjct: 509  RLYPG---------------SVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTG 553

Query: 561  KKLLE-----RGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKP- 614
            +  ++     RGE +   T +PL+ +  +    E LR  +         + + ++ Y+P 
Sbjct: 554  RDCIQYIKEQRGEPE---TFLPLDYLEVKP-TDEKLRELKG------AKLVIDVIRYEPP 603

Query: 615  ELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASI 674
             ++KA+++  G   VCDN+++A+++AF      +TV L G +F   G +SGGA    A  
Sbjct: 604  HIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKA 663

Query: 675  LTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ--------QWEMKTEEA 726
                ++  D     ++KE + R L EEL        K  +L+Q        Q  +K  ++
Sbjct: 664  RRWDEKAVD-----KLKEKKER-LTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQS 717

Query: 727  DLLQTKLQQSSYHKQQEE------------LDALKKTIEESEETLKNTKEIQRKAEEKY- 773
            DL QTK +  + + Q++             ++ +K+ I+  E  +K+ KE   + E++  
Sbjct: 718  DLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVF 777

Query: 774  -----EVLENKMKNAEAER-ERELKDAQKKLDCAKTKA------DASSKKMKEKQ----- 816
                 E+    ++  E E+ +R+ + A+K+L+    K       D    ++KE Q     
Sbjct: 778  EEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHM 837

Query: 817  --QEVEAITLELEELKREHTSYKQ-------QLEAVNEAIKSYESQIEVMAAEVAKNKES 867
              Q V+    E+E+LK+E   + +       QL+ +     + +S++     E+ + ++ 
Sbjct: 838  WEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKK 897

Query: 868  VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKI---KELDHNISKHKREA 924
            +  A +E+T  ++ +TA +T ++ K ++     +      +K+   K    +IS+ +  +
Sbjct: 898  LGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSS 957

Query: 925  E-----DGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKL 979
            +      G+ ++S +      I  +     +       +    +E     QKL E +  L
Sbjct: 958  QGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVL 1017

Query: 980  GRNV--NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKV 1037
             R    NM+AM  L    +++ +   +         K     E + +++    N  ++ V
Sbjct: 1018 QRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESV 1077

Query: 1038 NKDFGSIFSTLL--PGANAMLAP--PEGQTVLDGLEFK-VALGNTWKENLTELSGGQRSL 1092
              +   I+  L     A A L P  PE +  LDG+ +  VA G  ++  +  LSGG++++
Sbjct: 1078 ATNIDEIYKALSRNSSAQAFLGPENPE-EPYLDGINYNCVAPGKRFRP-MDNLSGGEKTV 1135

Query: 1093 VALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFT-HSQFIVVSLKEGMFN 1151
             AL+L+ ++  +KPAP ++LDE+DAALD ++   +   ++   T + Q IV+SLKE  + 
Sbjct: 1136 AALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYT 1195

Query: 1152 NANVL 1156
             A  L
Sbjct: 1196 KAESL 1200


>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
            sapiens]
          Length = 1288

 Score =  232 bits (592), Expect = 1e-60
 Identities = 288/1240 (23%), Positives = 536/1240 (43%), Gaps = 159/1240 (12%)

Query: 3    IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
            I  I+ + FKSYA    +  F   F+ I G NGSGKSN++DS+ F+ G     ++R+  L
Sbjct: 84   ITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKL 142

Query: 63   QDLVYKNGQ-AGITKASVSITFDNSDKKQSPLGFEV--HDEITVTRQVVIGGRNKYLING 119
              L++ + +   I   +V + F     K+    +EV  +    V+R       + Y I+G
Sbjct: 143  SVLIHNSDEHKDIQSCTVEVHFQKIIDKEGD-DYEVIPNSNFYVSRTACRDNTSVYHISG 201

Query: 120  VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPE-------ILSMIEEAAGT- 171
                   V +L  S G+++++  FLI+QG + ++  MKP         +L  +E+  G  
Sbjct: 202  KKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCG 261

Query: 172  RMYEYKKIAAQKTI---EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY----QKVM 224
            R+ E  K+  ++     E +  KL  +K + +E+       L+ E++  +E+     ++ 
Sbjct: 262  RLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEK-----DALEGEKNIAIEFLTLENEIF 316

Query: 225  REIEHLSRLYI---AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIK----AL 277
            R+  H+ + YI     +    E  K +  E+ KE+ +K   L  E+   +K +K     L
Sbjct: 317  RKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376

Query: 278  NHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKN 337
            N   + +E+ K+K T      LED      +V  K + A    KK    E+  +K+ EK 
Sbjct: 377  NKITKFIEENKEKFTQ---LDLEDV-----QVREKLKHATSKAKK---LEKQLQKDKEK- 424

Query: 338  MVEDSKTLAAKEKEV-KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEA 396
             VE+ K++ AK   +  + T   +AL++   K+ + L          + GL   ++  E 
Sbjct: 425  -VEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREK 483

Query: 397  TLAGQMMACKNDISK-----------------AQTEAKQAQMKLKHAQQELKNKQAEVKK 439
             L G   +     SK                 A ++  +A+  L  A + LK ++A ++ 
Sbjct: 484  ELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRD 543

Query: 440  MDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQ----------LSRDI 489
            ++    + ++       LKEK E E++KL  EE   +SL+    Q          ++R  
Sbjct: 544  IEGKLPQTEQ------ELKEK-EKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSR 596

Query: 490  GRLKETY--EALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
            G++ +    E    R P +          + R    G +     V  +S   AL+ +  +
Sbjct: 597  GKVLDAIIQEKKSGRIPGI----------YGRLGDLGAIDEKYDVAISSCCHALDYIVVD 646

Query: 548  RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
                  +D        L+R  +    T I L+K++         +    +  P+N     
Sbjct: 647  S-----IDIAQECVNFLKRQNIGVA-TFIGLDKMAVWA------KKMTEIQTPENTPRLF 694

Query: 608  SLVEYKPE-LQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGG 666
             LV+ K E +++A  F    T V DN+D A +VA+ K    R VTL G + +  GT++GG
Sbjct: 695  DLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGG 754

Query: 667  ARS-----QAASILTKF--QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQW 719
                      +S++ +   +E+  ++ +L+    +   ++E+   L+    K R  +++ 
Sbjct: 755  GSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREM 814

Query: 720  EMKTEEADL-LQTKLQQSSY-HKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
                E+    +Q  ++Q  Y + Q +EL+A        ++  K  +E     + +Y+ + 
Sbjct: 815  RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA 874

Query: 778  NKMKNAEAERER-----------ELKDAQKKLD--------CAK--TKADASSKKMKEKQ 816
             K    EAE +R           +LK  Q KLD        CA   TKA  + K      
Sbjct: 875  EKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934

Query: 817  QEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVT 876
            Q+ +   L  E   +E    +++++ +   +KS E +    AAEV KN  +  ++  E+ 
Sbjct: 935  QKAQDSVLRTE---KEIKDTEKEVDDLTAELKSLEDK----AAEVVKNTNAAEESLPEIQ 987

Query: 877  KQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM-L 935
            K+   +  +  VI+    E A  K+  +  +LK++++D +I++H  + +    ++SK+ L
Sbjct: 988  KEHRNLLQELKVIQEN--EHALQKDALS-IKLKLEQIDGHIAEHNSKIKYWHKEISKISL 1044

Query: 936  KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ----EMKEKLGRNVNMRAMNVL 991
               +    E      P      K  NP     ++  L+    EMK  LG      A+   
Sbjct: 1045 HPIEDNPIEEISVLSPEDLEAIK--NPDSITNQIALLEARCHEMKPNLG------AIAEY 1096

Query: 992  TEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPG 1051
             + EE Y   + +   +  ++       EDL +++       +  +       +  L  G
Sbjct: 1097 KKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLG 1156

Query: 1052 ANAMLAPPEG-QTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLFKPAPIY 1110
             +A L   +      +G+ F V       + +  LSGG+++L +L+L+ ++  +KP P+Y
Sbjct: 1157 GDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1216

Query: 1111 ILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMF 1150
             +DE+DAALD  +   +   +     ++QFI++SL+  MF
Sbjct: 1217 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMF 1256


>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
            sapiens]
          Length = 1288

 Score =  232 bits (592), Expect = 1e-60
 Identities = 288/1240 (23%), Positives = 536/1240 (43%), Gaps = 159/1240 (12%)

Query: 3    IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
            I  I+ + FKSYA    +  F   F+ I G NGSGKSN++DS+ F+ G     ++R+  L
Sbjct: 84   ITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKL 142

Query: 63   QDLVYKNGQ-AGITKASVSITFDNSDKKQSPLGFEV--HDEITVTRQVVIGGRNKYLING 119
              L++ + +   I   +V + F     K+    +EV  +    V+R       + Y I+G
Sbjct: 143  SVLIHNSDEHKDIQSCTVEVHFQKIIDKEGD-DYEVIPNSNFYVSRTACRDNTSVYHISG 201

Query: 120  VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPE-------ILSMIEEAAGT- 171
                   V +L  S G+++++  FLI+QG + ++  MKP         +L  +E+  G  
Sbjct: 202  KKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCG 261

Query: 172  RMYEYKKIAAQKTI---EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY----QKVM 224
            R+ E  K+  ++     E +  KL  +K + +E+       L+ E++  +E+     ++ 
Sbjct: 262  RLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEK-----DALEGEKNIAIEFLTLENEIF 316

Query: 225  REIEHLSRLYI---AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIK----AL 277
            R+  H+ + YI     +    E  K +  E+ KE+ +K   L  E+   +K +K     L
Sbjct: 317  RKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376

Query: 278  NHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKN 337
            N   + +E+ K+K T      LED      +V  K + A    KK    E+  +K+ EK 
Sbjct: 377  NKITKFIEENKEKFTQ---LDLEDV-----QVREKLKHATSKAKK---LEKQLQKDKEK- 424

Query: 338  MVEDSKTLAAKEKEV-KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEA 396
             VE+ K++ AK   +  + T   +AL++   K+ + L          + GL   ++  E 
Sbjct: 425  -VEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREK 483

Query: 397  TLAGQMMACKNDISK-----------------AQTEAKQAQMKLKHAQQELKNKQAEVKK 439
             L G   +     SK                 A ++  +A+  L  A + LK ++A ++ 
Sbjct: 484  ELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRD 543

Query: 440  MDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQ----------LSRDI 489
            ++    + ++       LKEK E E++KL  EE   +SL+    Q          ++R  
Sbjct: 544  IEGKLPQTEQ------ELKEK-EKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSR 596

Query: 490  GRLKETY--EALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
            G++ +    E    R P +          + R    G +     V  +S   AL+ +  +
Sbjct: 597  GKVLDAIIQEKKSGRIPGI----------YGRLGDLGAIDEKYDVAISSCCHALDYIVVD 646

Query: 548  RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
                  +D        L+R  +    T I L+K++         +    +  P+N     
Sbjct: 647  S-----IDIAQECVNFLKRQNIGVA-TFIGLDKMAVWA------KKMTEIQTPENTPRLF 694

Query: 608  SLVEYKPE-LQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGG 666
             LV+ K E +++A  F    T V DN+D A +VA+ K    R VTL G + +  GT++GG
Sbjct: 695  DLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGG 754

Query: 667  ARS-----QAASILTKF--QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQW 719
                      +S++ +   +E+  ++ +L+    +   ++E+   L+    K R  +++ 
Sbjct: 755  GSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREM 814

Query: 720  EMKTEEADL-LQTKLQQSSY-HKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
                E+    +Q  ++Q  Y + Q +EL+A        ++  K  +E     + +Y+ + 
Sbjct: 815  RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA 874

Query: 778  NKMKNAEAERER-----------ELKDAQKKLD--------CAK--TKADASSKKMKEKQ 816
             K    EAE +R           +LK  Q KLD        CA   TKA  + K      
Sbjct: 875  EKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934

Query: 817  QEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVT 876
            Q+ +   L  E   +E    +++++ +   +KS E +    AAEV KN  +  ++  E+ 
Sbjct: 935  QKAQDSVLRTE---KEIKDTEKEVDDLTAELKSLEDK----AAEVVKNTNAAEESLPEIQ 987

Query: 877  KQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM-L 935
            K+   +  +  VI+    E A  K+  +  +LK++++D +I++H  + +    ++SK+ L
Sbjct: 988  KEHRNLLQELKVIQEN--EHALQKDALS-IKLKLEQIDGHIAEHNSKIKYWHKEISKISL 1044

Query: 936  KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ----EMKEKLGRNVNMRAMNVL 991
               +    E      P      K  NP     ++  L+    EMK  LG      A+   
Sbjct: 1045 HPIEDNPIEEISVLSPEDLEAIK--NPDSITNQIALLEARCHEMKPNLG------AIAEY 1096

Query: 992  TEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPG 1051
             + EE Y   + +   +  ++       EDL +++       +  +       +  L  G
Sbjct: 1097 KKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLG 1156

Query: 1052 ANAMLAPPEG-QTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLFKPAPIY 1110
             +A L   +      +G+ F V       + +  LSGG+++L +L+L+ ++  +KP P+Y
Sbjct: 1157 GDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1216

Query: 1111 ILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMF 1150
             +DE+DAALD  +   +   +     ++QFI++SL+  MF
Sbjct: 1217 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMF 1256


>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 [Homo
            sapiens]
          Length = 1235

 Score =  201 bits (512), Expect = 3e-51
 Identities = 281/1267 (22%), Positives = 526/1267 (41%), Gaps = 185/1267 (14%)

Query: 2    HIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASN 61
            H++ +++E FKS+  R  +  F   F  I G NGSGKSN++D++ F++G   ++ +R  N
Sbjct: 3    HLELLLVENFKSWRGRQVIGPFRR-FTCIIGPNGSGKSNVMDALSFVMG-EKIANLRVKN 60

Query: 62   LQDLVYKN--GQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLING 119
            +Q+L++    G+   + ASV I +            E  +E T  R ++ GG +++  N 
Sbjct: 61   IQELIHGAHIGKPISSSASVKIIYVE----------ESGEEKTFAR-IIRGGCSEFRFND 109

Query: 120  VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRM----YE 175
               + +        +G+ V   + L+ QG +  +   KP E     EE + +      YE
Sbjct: 110  NLVSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYE 169

Query: 176  YKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYI 235
             KK   QK  E  +    + K I  E     ++K + ER     YQ ++ E++ ++++ +
Sbjct: 170  EKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAER-----YQSLLEELK-MNKIQL 223

Query: 236  AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
                L   + K+       E  ++ + ++ E         +L+H  E + K + KE G +
Sbjct: 224  QLFQLYHNEKKIHLLNTKLEHVNRDLSVKRE---------SLSHH-ENIVKARKKEHGML 273

Query: 296  LRSLEDALAEAQRVNT--KSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK 353
             R L+    E + V T    +    +K K       K+ ++ K  ++DS      EK+  
Sbjct: 274  TRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDS------EKQCS 327

Query: 354  KITDGLHALQ-EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEATLAGQMMACKNDISK 411
            K  D + AL+ E ++ DA   +  +Q    +   L    D   EA+   +    K  + K
Sbjct: 328  KQEDDIKALETELADLDAAWRSFEKQIEEEI---LHKKRDIELEASQLDRYKELKEQVRK 384

Query: 412  AQTEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKK 467
                  Q   KL+  Q+  + + A  K+    +    ++ +E +E  K+  EKLE   K 
Sbjct: 385  KVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKT 444

Query: 468  ----LNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNR---- 519
                L  ++ +EE+L+++  +    +    E    + +   N      + ++   R    
Sbjct: 445  CMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVL 504

Query: 520  --------NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLE--RGEL 569
                    + V G +  L          A+  V G  +  +VV +E   K  +   + E 
Sbjct: 505  EHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEER 564

Query: 570  KRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK-PELQKAMEFVFGTTF 628
                T + L+ +  + I  E LR  +         + + +++ + P+L+K ++FV G   
Sbjct: 565  AEPETFLALDYLDIKPIN-ERLRELKGC------KMVIDVIKTQFPQLKKVIQFVCGNGL 617

Query: 629  VCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARS-QAASILTKFQELKDVQDE 687
            VC+ M+ A+ +A       +TV L G +F   G +SGG+   +  +     +ELK+++D 
Sbjct: 618  VCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDR 677

Query: 688  LRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ--QSSYHKQQEEL 745
               K  EL+       GL  T  K   LKQ           +QT +Q  Q+     Q EL
Sbjct: 678  RSQKIQELK-------GLMKTLRKETDLKQ-----------IQTLIQGTQTRLKYSQNEL 719

Query: 746  DALKKT--IEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLD---- 799
            + +KK   +   +E  +   E+    E +  +L   +K    ER+R +K+ Q+K+D    
Sbjct: 720  EMIKKKHLVAFYQEQSQLQSELLN-IESQCIMLSEGIK----ERQRRIKEFQEKIDKVED 774

Query: 800  ------CAKTKAD---ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSY 850
                  C +   +       K  ++QQE++   LE E+ K   T    QLE     +K  
Sbjct: 775  DIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQK---TRLNVQLEYSRSHLKKK 831

Query: 851  ESQIEVMAAEVAKNKESVN---KAQEEVTKQKEVITAQDTVIK----AKYAEVAKHKEQN 903
             ++I  +   + K  E ++   KA+E   +    + A+   +K     + +   K + Q 
Sbjct: 832  LNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQI 891

Query: 904  NDSQLKIKELDHNISKHKREA-------EDGAAKVSKMLKDYDWINAERHLFG------- 949
             + + K   +D  + K ++E        E    +   +L D    + E  L         
Sbjct: 892  EEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDII 951

Query: 950  ------------------QPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV-------- 983
                              +   A++   ++ KE  + LQ  QE++  L   +        
Sbjct: 952  EVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011

Query: 984  --------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQ 1035
                    N+RA+  L    +++ +          +        E + +++       ++
Sbjct: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFE 1071

Query: 1036 KVNKDFGSIFSTLLPG--ANAMLAP--PEGQTVLDGLEFKVALGNTWKENLTELSGGQRS 1091
             V+     I+  L     A A L+P  PE +  L+G+ +           +  LSGG++ 
Sbjct: 1072 HVSISIDQIYKKLCRNNSAQAFLSPENPE-EPYLEGISYNCVAPGKRFMPMDNLSGGEKC 1130

Query: 1092 LVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF--IVVSLKEGM 1149
            + AL+L+ ++  F+PAP ++LDEVDAALD ++   +   ++   T  QF  IV+SLKE  
Sbjct: 1131 VAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQ-TQDQFQMIVISLKEEF 1189

Query: 1150 FNNANVL 1156
            ++ A+ L
Sbjct: 1190 YSRADAL 1196


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score =  112 bits (280), Expect = 2e-24
 Identities = 199/948 (20%), Positives = 390/948 (41%), Gaps = 122/948 (12%)

Query: 171  TRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL-----EYQKVMR 225
            T+  + K    ++ +E + A LK+   IL + ++ T  +L+ ++S+ L     +Y +++ 
Sbjct: 401  TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460

Query: 226  EI-EHLSRLYIA-YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEE 283
            E+ E   +L     Q   AE    +   +L+E + +  ++Q  + +   + +A   +++ 
Sbjct: 461  ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520

Query: 284  LEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKE----LEKNMV 339
                K+ E   +   L D L   Q++  +     + ++K +  EES + +    LE+N  
Sbjct: 521  KFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEA 580

Query: 340  -----------------------EDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAA 376
                                   E  K +A K+K++K+  D L + ++      E L   
Sbjct: 581  LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDI 640

Query: 377  QQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLK----HAQQELKN 432
            Q     + A +   +      LA +  A  +++ K Q        K++      Q E+ N
Sbjct: 641  QNMNFLLKAEVQKLQ-----ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 695

Query: 433  KQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRL 492
            K  E K ++       +AL++  +  + L +E    +  E  E+ + EK  +L       
Sbjct: 696  KMEEFKILND----QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL------- 744

Query: 493  KETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASL--ISVKDTSATTALELVAGERLY 550
             +T E LL     ++ A K+ E N  R     L   +  +  K     +   LV  E L 
Sbjct: 745  -KTVEELLET-GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLV--EELK 800

Query: 551  NVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVA--LS 608
             V+ + +    K+    EL     +   NK        + ++  +  +G   +  A  LS
Sbjct: 801  KVIHEKD---GKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS 857

Query: 609  LVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK-RIMTRTVTLGGDVFDPHGTLSGGA 667
            +     ELQ  ++   G     + M+  K V  +K + +  T     D+ + + +L    
Sbjct: 858  ITSKVQELQNLLK---GKE---EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911

Query: 668  RSQA------ASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE- 720
            +  A      AS  ++F+EL+ V   L+ KENEL+ LE  L   ++      QL Q  + 
Sbjct: 912  QEVAQHNLKEASSASQFEELEIV---LKEKENELKRLEAMLKERESDLSSKTQLLQDVQD 968

Query: 721  ----MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVL 776
                 K++   L Q   QQ+S     EEL    K I E E+ +     +  + +   + +
Sbjct: 969  ENKLFKSQIEQLKQQNYQQASSFPPHEEL---LKVISEREKEISG---LWNELDSLKDAV 1022

Query: 777  ENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE---- 832
            E++ K     RE+  +  +      K   D  +K  KE+QQ+VEA+ LE +E+ ++    
Sbjct: 1023 EHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPK 1082

Query: 833  -----HTSYKQQLEAVNEAIK------SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEV 881
                 + SY + L    +  K      S   +++V+  ++ +  E     Q E  K K V
Sbjct: 1083 VSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV 1142

Query: 882  ITAQDTVI----KAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKD 937
            +   + ++    ++   E  K K + ++S   IK++  + +  ++E E    ++    KD
Sbjct: 1143 LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE----RLRSENKD 1198

Query: 938  YDWINAER-HLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVN--MRAMNVLTEA 994
             + +  ER HL  +   A   ++    E  +    L E+++KL  + +  +R    L   
Sbjct: 1199 IENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLL 1258

Query: 995  EERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFG 1042
            + + N+ + K R  +N++ K+   +     K  Q+L +   K+ K  G
Sbjct: 1259 KAQLNETLTKLRTEQNERQKVAGDL----HKAQQSLELIQSKIVKAAG 1302



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 175/924 (18%), Positives = 366/924 (39%), Gaps = 116/924 (12%)

Query: 179  IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQ 238
            +    ++ +++ K K+ K +LEE++      +KE  +S +  +KV  E   +++      
Sbjct: 105  VETSSSVRERKKKEKKQKPVLEEQV------IKESDASKIPGKKV--EPVPVTKQPTPPS 156

Query: 239  FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKAL--NHEIEELEKRKDKETGGIL 296
               A   K    ++ K   D   K  E L    K+ +AL  + E ++      K+     
Sbjct: 157  EAAASKKKP-GQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKK 215

Query: 297  RSLEDALAEAQRV----------NTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLA 346
            +  E+   +   +          N  S    D ++     +  + + ++K+  +  KT  
Sbjct: 216  QKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTET 275

Query: 347  AKEKEVKKITDGLHALQEASNKDAEALAAA---QQHFNAVSAGLSSNEDGAEATLAGQMM 403
             KE    K  D L +L+     + EAL      ++    +   L  +  G   TL  Q+ 
Sbjct: 276  DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335

Query: 404  ACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEA 463
                 ++  + +A   + + K   QE+  ++             + +   + R+K+++  
Sbjct: 336  EKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-------------ERSNVVITRMKDRIGT 382

Query: 464  EMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
              K+ N  +NK     ++ +Q+     +++E  EA +A         +D   N       
Sbjct: 383  LEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLES 442

Query: 524  GLVASLISVKDTSATTALEL------VAGERLYNVVVDTEVTGKKLLERGELKRRYTIIP 577
               A L  ++   A    EL      +  E +     +   T  K ++  E +RR+  + 
Sbjct: 443  KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLK-VQLQEAERRWEEVQ 501

Query: 578  LNKISARCIAPETLR--VAQNLVGPDN----VHVAL--SLVEYKPELQKAMEFVFGTTFV 629
             + I  R    E  +  +    V  +N    +H  L  +LV  +   Q+ M+ +      
Sbjct: 502  -SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKR 560

Query: 630  CDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAAS------ILTKFQELKD 683
             +  ++ +    D  I+ +   L   +   H  ++    +   +      I  K +++K 
Sbjct: 561  VNKEESLQMQVQD--ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ 618

Query: 684  VQDELRIKENELRALEEELAGLKN---------------------TAEKYRQLKQQWEMK 722
             +D L  + + L + EEEL  ++N                      A +  +++Q   +K
Sbjct: 619  TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVK 678

Query: 723  TEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQR----KAEEKYEVLEN 778
             ++  LL+ +LQ    +K +E      K + +  + LK+  E+Q+     +E+  + +  
Sbjct: 679  DDKIRLLEEQLQHEISNKMEE-----FKILNDQNKALKS--EVQKLQTLVSEQPNKDVVE 731

Query: 779  KMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELK---REHTS 835
            +M+    E++ +LK  ++ L+    +     +++   + E  ++T E+++LK    +  S
Sbjct: 732  QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791

Query: 836  YKQQLEAVNEA-------IKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTV 888
            +   +E + +        IKS E  +E    +VA  +++V   ++E+   KE I     +
Sbjct: 792  FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI-GNVQL 850

Query: 889  IKAKYAEVAKHKEQNNDSQLKIKELDHNISKH-KREAEDGAAKVSKMLKDYDWINAERHL 947
             KA+   +   K Q   + LK KE   N  K    E E   A   K L+D    N     
Sbjct: 851  EKAQQLSITS-KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKA 909

Query: 948  FGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRI 1007
              Q  + ++ K  +     + L+ +  +KEK      + AM      +ER +DL  K ++
Sbjct: 910  HVQEVAQHNLKEASSASQFEELEIV--LKEKENELKRLEAM-----LKERESDLSSKTQL 962

Query: 1008 VEN--DKSKIL-TTIEDLDQKKNQ 1028
            +++  D++K+  + IE L Q+  Q
Sbjct: 963  LQDVQDENKLFKSQIEQLKQQNYQ 986


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score =  112 bits (280), Expect = 2e-24
 Identities = 199/948 (20%), Positives = 390/948 (41%), Gaps = 122/948 (12%)

Query: 171  TRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL-----EYQKVMR 225
            T+  + K    ++ +E + A LK+   IL + ++ T  +L+ ++S+ L     +Y +++ 
Sbjct: 401  TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460

Query: 226  EI-EHLSRLYIA-YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEE 283
            E+ E   +L     Q   AE    +   +L+E + +  ++Q  + +   + +A   +++ 
Sbjct: 461  ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520

Query: 284  LEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKE----LEKNMV 339
                K+ E   +   L D L   Q++  +     + ++K +  EES + +    LE+N  
Sbjct: 521  KFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEA 580

Query: 340  -----------------------EDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAA 376
                                   E  K +A K+K++K+  D L + ++      E L   
Sbjct: 581  LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDI 640

Query: 377  QQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLK----HAQQELKN 432
            Q     + A +   +      LA +  A  +++ K Q        K++      Q E+ N
Sbjct: 641  QNMNFLLKAEVQKLQ-----ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 695

Query: 433  KQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRL 492
            K  E K ++       +AL++  +  + L +E    +  E  E+ + EK  +L       
Sbjct: 696  KMEEFKILND----QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL------- 744

Query: 493  KETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASL--ISVKDTSATTALELVAGERLY 550
             +T E LL     ++ A K+ E N  R     L   +  +  K     +   LV  E L 
Sbjct: 745  -KTVEELLET-GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLV--EELK 800

Query: 551  NVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVA--LS 608
             V+ + +    K+    EL     +   NK        + ++  +  +G   +  A  LS
Sbjct: 801  KVIHEKD---GKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS 857

Query: 609  LVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK-RIMTRTVTLGGDVFDPHGTLSGGA 667
            +     ELQ  ++   G     + M+  K V  +K + +  T     D+ + + +L    
Sbjct: 858  ITSKVQELQNLLK---GKE---EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911

Query: 668  RSQA------ASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE- 720
            +  A      AS  ++F+EL+ V   L+ KENEL+ LE  L   ++      QL Q  + 
Sbjct: 912  QEVAQHNLKEASSASQFEELEIV---LKEKENELKRLEAMLKERESDLSSKTQLLQDVQD 968

Query: 721  ----MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVL 776
                 K++   L Q   QQ+S     EEL    K I E E+ +     +  + +   + +
Sbjct: 969  ENKLFKSQIEQLKQQNYQQASSFPPHEEL---LKVISEREKEISG---LWNELDSLKDAV 1022

Query: 777  ENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE---- 832
            E++ K     RE+  +  +      K   D  +K  KE+QQ+VEA+ LE +E+ ++    
Sbjct: 1023 EHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPK 1082

Query: 833  -----HTSYKQQLEAVNEAIK------SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEV 881
                 + SY + L    +  K      S   +++V+  ++ +  E     Q E  K K V
Sbjct: 1083 VSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV 1142

Query: 882  ITAQDTVI----KAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKD 937
            +   + ++    ++   E  K K + ++S   IK++  + +  ++E E    ++    KD
Sbjct: 1143 LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE----RLRSENKD 1198

Query: 938  YDWINAER-HLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVN--MRAMNVLTEA 994
             + +  ER HL  +   A   ++    E  +    L E+++KL  + +  +R    L   
Sbjct: 1199 IENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLL 1258

Query: 995  EERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFG 1042
            + + N+ + K R  +N++ K+   +     K  Q+L +   K+ K  G
Sbjct: 1259 KAQLNETLTKLRTEQNERQKVAGDL----HKAQQSLELIQSKIVKAAG 1302



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 175/924 (18%), Positives = 366/924 (39%), Gaps = 116/924 (12%)

Query: 179  IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQ 238
            +    ++ +++ K K+ K +LEE++      +KE  +S +  +KV  E   +++      
Sbjct: 105  VETSSSVRERKKKEKKQKPVLEEQV------IKESDASKIPGKKV--EPVPVTKQPTPPS 156

Query: 239  FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKAL--NHEIEELEKRKDKETGGIL 296
               A   K    ++ K   D   K  E L    K+ +AL  + E ++      K+     
Sbjct: 157  EAAASKKKP-GQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKK 215

Query: 297  RSLEDALAEAQRV----------NTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLA 346
            +  E+   +   +          N  S    D ++     +  + + ++K+  +  KT  
Sbjct: 216  QKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTET 275

Query: 347  AKEKEVKKITDGLHALQEASNKDAEALAAA---QQHFNAVSAGLSSNEDGAEATLAGQMM 403
             KE    K  D L +L+     + EAL      ++    +   L  +  G   TL  Q+ 
Sbjct: 276  DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335

Query: 404  ACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEA 463
                 ++  + +A   + + K   QE+  ++             + +   + R+K+++  
Sbjct: 336  EKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-------------ERSNVVITRMKDRIGT 382

Query: 464  EMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
              K+ N  +NK     ++ +Q+     +++E  EA +A         +D   N       
Sbjct: 383  LEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLES 442

Query: 524  GLVASLISVKDTSATTALEL------VAGERLYNVVVDTEVTGKKLLERGELKRRYTIIP 577
               A L  ++   A    EL      +  E +     +   T  K ++  E +RR+  + 
Sbjct: 443  KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLK-VQLQEAERRWEEVQ 501

Query: 578  LNKISARCIAPETLR--VAQNLVGPDN----VHVAL--SLVEYKPELQKAMEFVFGTTFV 629
             + I  R    E  +  +    V  +N    +H  L  +LV  +   Q+ M+ +      
Sbjct: 502  -SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKR 560

Query: 630  CDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAAS------ILTKFQELKD 683
             +  ++ +    D  I+ +   L   +   H  ++    +   +      I  K +++K 
Sbjct: 561  VNKEESLQMQVQD--ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ 618

Query: 684  VQDELRIKENELRALEEELAGLKN---------------------TAEKYRQLKQQWEMK 722
             +D L  + + L + EEEL  ++N                      A +  +++Q   +K
Sbjct: 619  TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVK 678

Query: 723  TEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQR----KAEEKYEVLEN 778
             ++  LL+ +LQ    +K +E      K + +  + LK+  E+Q+     +E+  + +  
Sbjct: 679  DDKIRLLEEQLQHEISNKMEE-----FKILNDQNKALKS--EVQKLQTLVSEQPNKDVVE 731

Query: 779  KMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELK---REHTS 835
            +M+    E++ +LK  ++ L+    +     +++   + E  ++T E+++LK    +  S
Sbjct: 732  QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791

Query: 836  YKQQLEAVNEA-------IKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTV 888
            +   +E + +        IKS E  +E    +VA  +++V   ++E+   KE I     +
Sbjct: 792  FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI-GNVQL 850

Query: 889  IKAKYAEVAKHKEQNNDSQLKIKELDHNISKH-KREAEDGAAKVSKMLKDYDWINAERHL 947
             KA+   +   K Q   + LK KE   N  K    E E   A   K L+D    N     
Sbjct: 851  EKAQQLSITS-KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKA 909

Query: 948  FGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRI 1007
              Q  + ++ K  +     + L+ +  +KEK      + AM      +ER +DL  K ++
Sbjct: 910  HVQEVAQHNLKEASSASQFEELEIV--LKEKENELKRLEAM-----LKERESDLSSKTQL 962

Query: 1008 VEN--DKSKIL-TTIEDLDQKKNQ 1028
            +++  D++K+  + IE L Q+  Q
Sbjct: 963  LQDVQDENKLFKSQIEQLKQQNYQ 986


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  111 bits (278), Expect = 4e-24
 Identities = 189/876 (21%), Positives = 378/876 (43%), Gaps = 118/876 (13%)

Query: 174  YEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRL 233
            ++ K +      EK+ A +KE  T L+E +  +  + KE     LE +K++  ++  + L
Sbjct: 834  FKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKE-----LE-EKMVSLLQEKNDL 887

Query: 234  YIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETG 293
             +  Q   AE   +  AEE     D++IK + +L   + K+K +N  +E+ E+  + E  
Sbjct: 888  QLQVQ---AEQDNLADAEE---RCDQLIKNKIQL---EAKVKEMNERLED-EEEMNAELT 937

Query: 294  GILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK 353
               R LED  +E +R         D  +  LA  E ++   E  +   ++ +A  ++ + 
Sbjct: 938  AKKRKLEDECSELKR-------DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 990

Query: 354  KITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQ 413
            K+T    ALQEA  +  + L A +   N ++         A+  L  Q+    +D+  + 
Sbjct: 991  KLTKEKKALQEAHQQALDDLQAEEDKVNTLTK--------AKVKLEQQV----DDLEGSL 1038

Query: 414  TEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEEN 473
             + K+ +M L+ A+          +K++   +  QE++  ++  K++L+  +KK ++E N
Sbjct: 1039 EQEKKVRMDLERAK----------RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELN 1088

Query: 474  KEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVK 533
               + +E  + L     +L++  + L AR   L    ++ E           + S +S +
Sbjct: 1089 ALNARIEDEQALG---SQLQKKLKELQARIEELE---EELEAERTARAKVEKLRSDLSRE 1142

Query: 534  DTSATTALELVAGERLYNVVVDT--EVTGKKL---LERGELKRRYTIIPLNKISARCIAP 588
                +  LE   G     + ++   E   +K+   LE   L+   T   L K  A  +A 
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1202

Query: 589  ETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTR 648
               ++       DN    L  V+ K E +K+ EF      V  NM+   K   +   M R
Sbjct: 1203 LGEQI-------DN----LQRVKQKLEKEKS-EFKLELDDVTSNMEQIIKAKANLEKMCR 1250

Query: 649  TVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNT 708
            T+    D  + H + +   +     + ++  +L+    EL  + +E  AL  +L   K T
Sbjct: 1251 TLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLT 1307

Query: 709  -AEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQR 767
              ++   LK+Q E + +  + L   LQ + +     + D L++  EE  E     + +  
Sbjct: 1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARH-----DCDLLREQYEEETEAKAELQRVLS 1362

Query: 768  KAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELE 827
            KA  +      K +    +R  EL++A+KKL          +++++E ++ VEA+  +  
Sbjct: 1363 KANSEVAQWRTKYETDAIQRTEELEEAKKKL----------AQRLQEAEEAVEAVNAKCS 1412

Query: 828  ELKREHTSYKQQLEAV-------NEAIKSYESQIEVMAAEVAKNKESVNKAQEEV-TKQK 879
             L++     + ++E +       N A  + + +       +A+ K+   ++Q E+ + QK
Sbjct: 1413 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472

Query: 880  EVITAQDTVIKAK--YAEVAKH----KEQNNDSQLKIKELD----------HNISKHKRE 923
            E  +    + K K  Y E  +H    K +N + Q +I +L           H + K +++
Sbjct: 1473 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQ 1532

Query: 924  AEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV 983
             E    ++   L++ +   +  H  G+   A         E  ++L +  E  E+  RN 
Sbjct: 1533 LEAEKMELQSALEEAE--ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN- 1589

Query: 984  NMRAMNVL---TEAEER-YNDLMKKKRIVENDKSKI 1015
            ++R ++ L    +AE R  N+ ++ K+ +E D +++
Sbjct: 1590 HLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEM 1625



 Score =  101 bits (251), Expect = 5e-21
 Identities = 168/783 (21%), Positives = 342/783 (43%), Gaps = 133/783 (16%)

Query: 185  IEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQ----KVMREIEHLSRLYIAYQFL 240
            I K +A L+++   LE+++     K +E + S  +      K+  E   LSR     + L
Sbjct: 1238 IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEAL 1297

Query: 241  LAEDTK-----VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
            +++ T+      +  E+LK   ++ +K +  L+     +++  H+ + L ++ ++ET   
Sbjct: 1298 ISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQYEEET--- 1351

Query: 296  LRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKR-KELEKNMVEDSKTLAAKEKEVKK 354
                 +A AE QRV +K+ S     +     +  +R +ELE+   + ++ L   E+ V+ 
Sbjct: 1352 -----EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406

Query: 355  ITDGLHALQEASNK---DAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISK 411
            +     +L++  ++   + E L    +  NA +A L   +   +  LA           +
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA-----------E 1455

Query: 412  AQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYE 471
             + + +++Q +L+ +Q+E ++   E+ K+ + Y +  E LE  KR  + L+ E+  L  +
Sbjct: 1456 WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1515

Query: 472  ---ENKEESLLEK-RRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVA 527
                 K    LEK R+QL  +   L+   E   A   +        +  +N+  +K  + 
Sbjct: 1516 LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ--IKAEIE 1573

Query: 528  SLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIA 587
              ++ KD       E+   +R +  VVD+  T      R                     
Sbjct: 1574 RKLAEKDE------EMEQAKRNHLRVVDSLQTSLDAETRSR------------------- 1608

Query: 588  PETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMT 647
             E LRV + + G  N          + E+Q               + +A ++A + +   
Sbjct: 1609 NEALRVKKKMEGDLN----------EMEIQ---------------LSHANRMAAEAQKQV 1643

Query: 648  RTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKN 707
            +++           +L    + Q    +    +LK+    +  + N L+A  EEL  +  
Sbjct: 1644 KSLQ----------SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693

Query: 708  TAEKYRQLKQQWEMKTEE-ADLLQTKLQQSSYHKQQEELDA----LKKTIEESEETLKNT 762
              E+ R+L +Q  ++T E   LL +  Q +S   Q++++DA    L+  +EE+ +  +N 
Sbjct: 1694 QTERSRKLAEQELIETSERVQLLHS--QNTSLINQKKKMDADLSQLQTEVEEAVQECRNA 1751

Query: 763  KEIQRKAEEKYEVLENKMK-----NAEAER-----ERELKDAQKKLDCAKTKADASSKKM 812
            +E  +KA     ++  ++K     +A  ER     E+ +KD Q +LD A+  A    KK 
Sbjct: 1752 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811

Query: 813  KEKQQEVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKA 871
             +K   +EA   ELE EL+ E    K+  E+V    KS E +I+ +  +  ++++++ + 
Sbjct: 1812 LQK---LEARVRELENELEAEQ---KRNAESVKGMRKS-ERRIKELTYQTEEDRKNLLRL 1864

Query: 872  QEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKV 931
            Q+ V K +         +KA   +  + +EQ N +  K +++ H + + +  A+   ++V
Sbjct: 1865 QDLVDKLQ-------LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQV 1917

Query: 932  SKM 934
            +K+
Sbjct: 1918 NKL 1920



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 199/1000 (19%), Positives = 392/1000 (39%), Gaps = 152/1000 (15%)

Query: 149  RITKVLNMKPPEILSMIEEAAG-----TRMYEYKKI---AAQKTIEKKEAKLKEIKTI-- 198
            ++ K  +    ++ ++ EE AG      ++ + KK    A Q+ ++  +A+  ++ T+  
Sbjct: 963  KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTK 1022

Query: 199  ----LEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELK 254
                LE+++      L++E+   ++ ++  R++E   +L      +  E+ K +  E LK
Sbjct: 1023 AKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL-TQESIMDLENDKQQLDERLK 1081

Query: 255  EMQDKVIKLQEEL-------SENDKKIKALNHEIEELEKRKDKET----------GGILR 297
            +   ++  L   +       S+  KK+K L   IEELE+  + E             + R
Sbjct: 1082 KKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR 1141

Query: 298  SLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKE----VK 353
             LE+     +     +    ++ KK  A  +  R++LE+  ++   T AA  K+    V 
Sbjct: 1142 ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVA 1201

Query: 354  KITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDG---AEATLAGQMMACKNDIS 410
            ++ + +  LQ    K    L   +  F      ++SN +    A+A L       ++ ++
Sbjct: 1202 ELGEQIDNLQRVKQK----LEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN 1257

Query: 411  KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLK----EKLEAEMK 466
            + +++A++ Q  +     +    Q E  ++     + +  +  + R K    ++LE   +
Sbjct: 1258 EHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR 1317

Query: 467  KLNYEENKEESLLEKRRQLSRDIGRLKETYEA---LLARFPNLRFAYKDPEKNWNRNCVK 523
            +L  E   + +L    +    D   L+E YE      A    +          W      
Sbjct: 1318 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET 1377

Query: 524  GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISA 583
              +     +++     A      +RL       E    K     + K R      N+I  
Sbjct: 1378 DAIQRTEELEEAKKKLA------QRLQEAEEAVEAVNAKCSSLEKTKHRLQ----NEIED 1427

Query: 584  RCIAPETLRVAQNLVGPDNVHVALSLVEYKP-------ELQKAMEFVFGTTFVCDNMDNA 636
              +  E    A   +     +    L E+K        EL+ + +     +     + NA
Sbjct: 1428 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1487

Query: 637  KKVAFD--KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENE 694
             + + +  +        L  ++ D    L    ++          EL+ V+ +L  ++ E
Sbjct: 1488 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGKT--------IHELEKVRKQLEAEKME 1539

Query: 695  LR-ALEEELAGLKNTAEK-------YRQLKQQWEMKTEE---------------ADLLQT 731
            L+ ALEE  A L++   K       + Q+K + E K  E                D LQT
Sbjct: 1540 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1599

Query: 732  KLQQSSYHKQQEELDALKKTIE----ESEETLKNTKEIQRKAEEKYEVLENKMKNAEAER 787
             L   +  + + E   +KK +E    E E  L +   +  +A+++ + L++ +K+ + + 
Sbjct: 1600 SLDAET--RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ- 1656

Query: 788  ERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAI 847
               L DA +  D  K       ++    Q E+E +   +E+ +R     +Q+L   +E +
Sbjct: 1657 ---LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1713

Query: 848  KSYESQIEVMAAEVAKNKESVNKAQEEVTKQ-KEVITAQDTVIK-----AKYAEVAKHKE 901
            +   SQ   +  +  K    +++ Q EV +  +E   A++   K     A  AE  K KE
Sbjct: 1714 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK-KE 1772

Query: 902  QNNDSQLK---------IKELDHNISKHKREAEDGAAK-----------VSKMLKDYDWI 941
            Q+  + L+         IK+L H + + ++ A  G  K           +   L+     
Sbjct: 1773 QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKR 1832

Query: 942  NAERHLFGQPNSAYDFK--TNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYN 999
            NAE  + G   S    K  T   +E  + L +LQ++ +KL   V         EAEE+ N
Sbjct: 1833 NAE-SVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQA-EEAEEQAN 1890

Query: 1000 DLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNK 1039
              + K R V++          +LD+ + +A +IA  +VNK
Sbjct: 1891 TNLSKFRKVQH----------ELDEAEERA-DIAESQVNK 1919



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 133/691 (19%), Positives = 277/691 (40%), Gaps = 110/691 (15%)

Query: 388  SSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD 447
            S+  +   A++  +    K  + K++   K+ + K+    QE  + Q +V+         
Sbjct: 842  SAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA 901

Query: 448  QEALEAVKRLKEKLEAEMKKLNY----EENKEESLLEKRRQLSRDIGRLKETYEALLARF 503
            +E  + + + K +LEA++K++N     EE     L  K+R+L  +   LK   + L    
Sbjct: 902  EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL---- 957

Query: 504  PNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL 563
              L  A  + EK+   N VK L   +  + +  A    E                  KK 
Sbjct: 958  -ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE------------------KKA 998

Query: 564  LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFV 623
            L+    +                A + L+  ++ V         +L + K +L++ ++ +
Sbjct: 999  LQEAHQQ----------------ALDDLQAEEDKVN--------TLTKAKVKLEQQVDDL 1034

Query: 624  FGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD 683
             G+      ++  KKV  D     R              L G  +    SI+    + + 
Sbjct: 1035 EGS------LEQEKKVRMDLERAKRK-------------LEGDLKLTQESIMDLENDKQQ 1075

Query: 684  VQDELRIKENELRAL----EEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYH 739
            + + L+ K+ EL AL    E+E A      +K ++L+ + E   EE +  +T   +    
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135

Query: 740  KQQ--EELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKK 797
            +     EL+ + + +EE+        E+ +K E +++ +   ++ A  + E      +KK
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1195

Query: 798  -----------LDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEA 846
                       +D  +       K+  E + E++ +T  +E++ +   + ++    + + 
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQ 1255

Query: 847  IKSYESQIEVMAAEV---AKNKESVNKAQEEVTKQ---KEVITAQDTVIKAKYAEVAKHK 900
            +  + S+ E     V      +  +     E+++Q   KE + +Q T  K  Y +  +  
Sbjct: 1256 MNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDL 1315

Query: 901  EQNNDSQLKIKE-LDHNISKHKREAEDGAAKVSKMLKDYDWINAE-RHLFGQPNSAY-DF 957
            ++  + ++K K  L H +   + + +     + +  ++     AE + +  + NS    +
Sbjct: 1316 KRQLEEEVKAKNALAHALQSARHDCD----LLREQYEEETEAKAELQRVLSKANSEVAQW 1371

Query: 958  KTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILT 1017
            +T    +A QR ++L+E K+KL +         L EAEE    +  K   +E  K ++  
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQR--------LQEAEEAVEAVNAKCSSLEKTKHRLQN 1423

Query: 1018 TIEDL--DQKKNQALNIAWQKVNKDFGSIFS 1046
             IEDL  D +++ A   A  K  ++F  I +
Sbjct: 1424 EIEDLMVDVERSNAAAAALDKKQRNFDKILA 1454



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 85/417 (20%), Positives = 172/417 (41%), Gaps = 91/417 (21%)

Query: 149  RITKVLNMKPPEILSMIEEAAGTRMYEYKKIA-----------------AQKTIEKKEAK 191
            ++ K L  +  E+ S +EEA  +  +E  KI                  A+K  E ++AK
Sbjct: 1528 KVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1587

Query: 192  ------LKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYI-------AYQ 238
                  +  ++T L+ E     + L+ ++    +  ++  ++ H +R+         + Q
Sbjct: 1588 RNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1647

Query: 239  FLLAE-----DTKVRSAEELKE-----------MQDKVIKL--------------QEELS 268
             LL +     D  VR+ ++LKE           +Q ++ +L              ++EL 
Sbjct: 1648 SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI 1707

Query: 269  ENDKKIKALNHEIEEL---EKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLA 325
            E  ++++ L+ +   L   +K+ D +   +   +E+A+ E +    K++ A  +    + 
Sbjct: 1708 ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKA--ITDAAMM 1765

Query: 326  CEESKRKE--------LEKNMVEDSKTLAAKEKEVKKIT--DGLHALQ--EASNKDAEAL 373
             EE K+++        ++KNM +  K L  +  E ++I    G   LQ  EA  ++ E  
Sbjct: 1766 AEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENE 1825

Query: 374  AAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNK 433
              A+Q  NA S       +     L  Q    + ++ + Q    + Q+K+K  +++ +  
Sbjct: 1826 LEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEA 1885

Query: 434  QAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIG 490
            + +     S +RK Q  L+  +   +  E+++ KL              R  SRDIG
Sbjct: 1886 EEQANTNLSKFRKVQHELDEAEERADIAESQVNKL--------------RAKSRDIG 1928



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 31/133 (23%), Positives = 61/133 (45%), Gaps = 16/133 (12%)

Query: 892  KYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQP 951
            K AE  K      +   ++KE        ++E E+   K+  +L++ + +  +       
Sbjct: 841  KSAEREKEMASMKEEFTRLKEALEKSEARRKELEE---KMVSLLQEKNDLQLQ------- 890

Query: 952  NSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYN-DLMKKKRIVEN 1010
                  + +N  +A +R  +L  +K K+     ++ MN   E EE  N +L  KKR +E+
Sbjct: 891  ---VQAEQDNLADAEERCDQL--IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED 945

Query: 1011 DKSKILTTIEDLD 1023
            + S++   I+DL+
Sbjct: 946  ECSELKRDIDDLE 958


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  107 bits (268), Expect = 5e-23
 Identities = 201/970 (20%), Positives = 395/970 (40%), Gaps = 158/970 (16%)

Query: 132  CSVGLNVNNPHFLIMQGRITKVLNM--KPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE 189
            C+  L + N  +  +  ++  +L +  +  E+ +  +E   T+  + K     K +E+K 
Sbjct: 823  CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 882

Query: 190  AKLKEIKTILEEEI---TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTK 246
            ++L E K +L+E++   T    + +E R      ++ + EI H     +  +    ED  
Sbjct: 883  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRG 938

Query: 247  VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEA 306
             +   E K+M  +++ L+E+L E +   + L  E    E +        ++ LED +   
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK--------IKKLEDEILVM 990

Query: 307  QRVNTKSQSAFDLKKK-------NLACEESKRKELEK------NMVEDSKTLAAKEKEVK 353
               N K      L ++       NLA EE K K L K      +M+ + +    KE++ +
Sbjct: 991  DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050

Query: 354  KITDGLHALQEASNKD-AEALAAAQQHFNAVSAGLSSNEDGAEATLA--GQMMACKNDIS 410
            +  + L    E    D  E +A  Q     +   L+  E+  +A LA     +A KN+  
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110

Query: 411  KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVK-RLKEKLE--AEMKK 467
            K   + ++ +  +   Q++L +++A   K +   R   E LEA+K  L++ L+  A  ++
Sbjct: 1111 K---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167

Query: 468  LNYEENKEESLL-----EKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCV 522
            L  +  +E ++L     E+ R     +  +++ +   +         +K  + N ++N  
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-- 1225

Query: 523  KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
                      K T      +L AGE          V G+   E  E K++     + ++ 
Sbjct: 1226 ----------KQTLEKENADL-AGE--------LRVLGQAKQE-VEHKKKKLEAQVQELQ 1265

Query: 583  ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD 642
            ++C   E  R   N    D VH          +LQ  +E V G     +           
Sbjct: 1266 SKCSDGERARAELN----DKVH----------KLQNEVESVTGMLNEAEG---------- 1301

Query: 643  KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD-VQDELRIKEN---ELRAL 698
                 + + L  DV               AS+ ++ Q+ ++ +Q+E R K N   +LR L
Sbjct: 1302 -----KAIKLAKDV---------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341

Query: 699  EEELAGLKNTAEKYRQLKQQWE--MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
            EEE   L++  ++  + KQ  E  + T    L  +K +   +    E L+  KK  ++  
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401

Query: 757  ETLKNTKEIQRKAEEKYEVLENKMKN------AEAERERE----LKDAQKKLDCAKTKAD 806
            E L    E +  A +K E  +N+++        + + +R+    L+  Q+K D    +  
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461

Query: 807  ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAK 863
              S K  +++   EA   E  E + +  S  + LE   EA +  E   +++ AE   +  
Sbjct: 1462 NISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518

Query: 864  NKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK--------ELDH 915
            +K+ V K   E+ K K  +  Q   +K +  E+    +   D++L+++        + + 
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578

Query: 916  NISKHKREAEDGAAKVSKMLKDYDW------------INAERHLFGQPNS---AYDFKTN 960
            ++     + E+   ++ + L +Y+               A++ L G         D    
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638

Query: 961  NPKEAGQRLQKLQ-EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTI 1019
              +EA ++L+KLQ +MK+      + RA      A  + N+  KK + +E D  ++   +
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE--KKAKSLEADLMQLQEDL 1696

Query: 1020 EDLDQKKNQA 1029
               ++ + QA
Sbjct: 1697 AAAERARKQA 1706



 Score =  103 bits (257), Expect = 1e-21
 Identities = 148/737 (20%), Positives = 306/737 (41%), Gaps = 111/737 (15%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
            E+  A+L +    L+ E+      L E     +   K+ +++  LS      Q LL E+T
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI---KLAKDVASLSSQLQDTQELLQEET 1328

Query: 246  --KVRSAEELKEMQDKVIKLQEELSEN-------DKKIKALNHEIEELEKRKDKETGGIL 296
              K+  + +L++++++   LQ++L E        ++ I  LN ++ +  K+K ++    +
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD-SKKKLQDFASTV 1387

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
             +LE+     Q+        ++ K    A    K ++ +  + ++   L       +++ 
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEK----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443

Query: 357  DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
              L    E   +  + L A +++   +S+  +   D AEA  A +       +++A  EA
Sbjct: 1444 SNL----EKKQRKFDQLLAEEKN---ISSKYADERDRAEAE-AREKETKALSLARALEEA 1495

Query: 417  KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEE 476
             +A+ +L+   + LK +  ++        K+   LE  KR  E    EMK    EE ++E
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT-QLEELEDE 1554

Query: 477  SLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTS 536
                +  +L     RL+   +AL  +F     A  +  +   R   + L      ++D  
Sbjct: 1555 LQATEDAKL-----RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 537  ATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQN 596
               AL   A ++L   + D E+     ++     R   I  L K+ A+            
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKG----REEAIKQLRKLQAQ------------ 1653

Query: 597  LVGPDNVHVALSLVEYKPELQKAM---EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLG 653
                        + +++ EL+ A    + +F T       +N KK            +L 
Sbjct: 1654 ------------MKDFQRELEDARASRDEIFATA-----KENEKKAK----------SLE 1686

Query: 654  GDVFDPHGTLSGGARSQAASILTKFQELKD-----------VQDELRIKENELRALEEEL 702
             D+      L+   R++  + L K +EL +           +QDE R  E  +  LEEEL
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745

Query: 703  ----AGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEET 758
                  ++  +++ R+  QQ E  + E    ++  Q++   +QQ E              
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE-------------- 1791

Query: 759  LKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQE 818
             +  KE++ K  E    +++K K+  A  E ++   +++++    +  A++K +K+K ++
Sbjct: 1792 -RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850

Query: 819  VEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAKNKESVNKAQEEV 875
            ++ I L++E+ ++    YK+Q E  N  +K  + Q+E    E   +  N+  + +  +E 
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910

Query: 876  TKQKEVITAQDTVIKAK 892
            T+  E +  +   +K+K
Sbjct: 1911 TESNEAMGREVNALKSK 1927



 Score =  101 bits (251), Expect = 5e-21
 Identities = 157/815 (19%), Positives = 347/815 (42%), Gaps = 89/815 (10%)

Query: 178  KIAAQKTIEKKEAKLKEIK---TILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY 234
            K A  +     EA+++E++       EE+T  +++ K  +++ L+  K   E E+     
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENAD--- 1235

Query: 235  IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGG 294
            +A +  +    K     + K+++ +V +LQ + S+ ++    LN ++ +L+   +  TG 
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG- 1294

Query: 295  ILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKK 354
                L +A  +A ++            K++A   S+ ++ ++ + E+++       ++++
Sbjct: 1295 ---MLNEAEGKAIKL-----------AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 355  ITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQT 414
            + +  ++LQ+  +++ EA    ++H + ++  LS ++         ++    + +   + 
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK--------KLQDFASTVEALEE 1392

Query: 415  EAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV-------KRLKEKLEAEMKK 467
              K+ Q ++++  Q+ + K A   K++    + Q+ L+ +       ++L   LE + +K
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452

Query: 468  LNY---EENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKG 524
             +    EE    S     R  +    R KET    LAR        K+  +  N+  +K 
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKA 1511

Query: 525  LVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISAR 584
             +  L+S KD       EL   +R     ++   T  + LE  EL+         +++ +
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQ 1570

Query: 585  CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKR 644
             +  +  R   +L   D  +      E + +LQ+ +   + T    +    A   A  K+
Sbjct: 1571 ALKGQFER---DLQARDEQNE-----EKRRQLQRQLH-EYETELEDERKQRALAAAAKKK 1621

Query: 645  IMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENELRALEEE 701
                   L GD+ D           R +A   L K Q ++KD Q EL     + RA  +E
Sbjct: 1622 -------LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE----DARASRDE 1670

Query: 702  LAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTI-EESEETLK 760
            +       EK        + K+ EADL+Q +   ++  + +++ D  K+ + EE   +L 
Sbjct: 1671 IFATAKENEK--------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722

Query: 761  NTKEIQ---RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQ 817
                +Q   R+ E +   LE +++  +   E  + D  +K   A  +A+  S ++  ++ 
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRK---ATQQAEQLSNELATERS 1778

Query: 818  EVEAITLELEELKREHTSYKQQLEAVNEAIKS-YESQIEVMAAEVAKNKESVNKAQEEVT 876
              +      ++L+R++   + +L  +  A+KS ++S I  + A++A+ +E V +   E  
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 877  KQKEVITAQDTVIKAKYAEVA-------KHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
               + +  +D  +K    +V        ++KEQ      ++K+L   + + + E++   A
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 930  KVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKE 964
               K+ ++ D         G+  +A   K     E
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 188/933 (20%), Positives = 373/933 (39%), Gaps = 120/933 (12%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE-HLSRLYIAYQFLLAE- 243
            E+K   L ++K   E  I+    +LK+E  S  E +K+ R++E   S  +     L A+ 
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078

Query: 244  -DTKVRSAEELKEMQDKVIKLQEELSEND---KKIKALNHEIEELEKRKDKETGG---IL 296
             + K++ A++ +E+Q  + +L +E+++ +   KKI+ L   I +L++  D E        
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
            +   D   E + + T+ +   D    + A ++  R + E+ +    K L   ++E +   
Sbjct: 1139 KQKRDLGEELEALKTELEDTLD----STATQQELRAKREQEVTVLKKAL---DEETRSHE 1191

Query: 357  DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE---ATLAGQMMACKNDISKAQ 413
              +  +++   +  E L    + F    A L  N+   E   A LAG++      + +A+
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV----LGQAK 1247

Query: 414  TEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKKLN 469
             E +  + KL+   QEL++K ++ ++    ++    K Q  +E+V  +  + E +  KL 
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 470  YEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYK---DPEKNWNRNCVKGLV 526
             +     S L+  ++L ++  R K      L +    R + +   D E    +N  + + 
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367

Query: 527  ASLISVKDTS------ATTALELVAGERLYNVVVDT---------------EVTGKKL-- 563
               I + D+       A+T   L  G++ +   ++                E T  +L  
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427

Query: 564  ------------------LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHV 605
                              LE+ + K    +     IS++         A+     +    
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE---AREKETK 1484

Query: 606  ALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSG 665
            ALSL     E  +A E           ++   K+   K  M   V+   DV      L  
Sbjct: 1485 ALSLARALEEALEAKE----------ELERTNKML--KAEMEDLVSSKDDVGKNVHELEK 1532

Query: 666  GARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEE 725
              R+    +     +L++++DEL+  E+    LE  +  LK   E  R L+ + E   E+
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEK 1590

Query: 726  ADLLQTKLQQ-----SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
               LQ +L +         KQ+    A KK +E   + L+   +   K  E+      K+
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650

Query: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV--------------EAITLEL 826
            +    + +REL+DA+   D     A  + KK K  + ++              +   LE 
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710

Query: 827  EELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK---NKESVNKAQEEVTKQ----- 878
            EEL  E  S      A+ +  +  E++I  +  E+ +   N E+++    + T+Q     
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770

Query: 879  KEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNI-SKHKREAEDGAAKVSKMLKD 937
             E+ T + T  K + A   + + QN + + K+ E++  + SK K       AK++++ + 
Sbjct: 1771 NELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829

Query: 938  YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNV---LTEA 994
             +    E+    +     D K        +  +K+ E  ++     N R   +   L EA
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889

Query: 995  EERYNDLMKKKRIVENDKSKILTTIEDLDQKKN 1027
            EE    +   +R ++ +  +   + E + ++ N
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVN 1922



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 179/896 (19%), Positives = 354/896 (39%), Gaps = 99/896 (11%)

Query: 204  TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKL 263
            T  +  L+EER   L+   V+   + + R Y+A +       ++ + + ++      +KL
Sbjct: 772  TGVLAHLEEERD--LKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKL 829

Query: 264  QE----ELSENDKKIKALNHEIEELEKRKDK--ETGGILRSLEDALAEAQRVNTKSQSAF 317
            +      L    K +  +  + EE++ ++D+  +T    +  E+ L E ++ +++     
Sbjct: 830  RNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK 889

Query: 318  DLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQ 377
            +L ++ L  E     E E+  V     LAAK++E+++I   + A  E      + L A +
Sbjct: 890  NLLQEQLQAETELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945

Query: 378  QHFNAVSAGLSSN---EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
            +        L      E+ A   L  + +  +  I K + E      +     +E K  +
Sbjct: 946  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005

Query: 435  AEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESL---LEK-RRQLSRDIG 490
              +  + +   +++E  + + +LK K E+ + +L     KEE     LEK +R+L  D  
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065

Query: 491  RLKETYEALLARFPNLR-------------FAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
               E    L A+   L+              A  D E     N +K +      + D   
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 538  TTALELVA-----------GERLYNVVVDTEVTGKKLLERGEL--KRRYTIIPLNKISAR 584
                E  A           GE L  +  + E T      + EL  KR   +  L K    
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 585  CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT--TFVCDNMDNAKKVAF- 641
                   +V +  +   +      L E   + ++A   +     T   +N D A ++   
Sbjct: 1186 ETRSHEAQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243

Query: 642  ---DKRIMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENEL 695
                + +  +   L   V +     S G  AR++    + K Q E++ V   L   E + 
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303

Query: 696  RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES 755
              L +++A L +  +  ++L Q+   +T +   + TKL+Q      +EE ++L+  ++E 
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQE---ETRQKLNVSTKLRQ-----LEEERNSLQDQLDEE 1355

Query: 756  EETLKN------TKEIQ-RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADAS 808
             E  +N      T  IQ   +++K +   + ++  E  ++R  K+ +      + KA A 
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415

Query: 809  SKKMKEK---QQEVEAITLELE-------ELKREHTSYKQQLEAVNEAIKSYESQIEVMA 858
             K  K K   QQE++ + ++L+        L+++   + Q L         Y  + +   
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475

Query: 859  AEVAKNKE----SVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD 914
            AE A+ KE    S+ +A EE  + KE +   + ++KA+  ++   K+        + +  
Sbjct: 1476 AE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-------VGKNV 1527

Query: 915  HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974
            H + K KR  E    ++   L++      E  L    ++    + N     GQ  + LQ 
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEE-----LEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582

Query: 975  MKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
              E+       +    L E E    D  K++ +    K K+   ++DL+ + + A+
Sbjct: 1583 RDEQ-NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 74/375 (19%), Positives = 168/375 (44%), Gaps = 29/375 (7%)

Query: 675  LTKFQELKDVQDELRIKEN-------ELRALEEELAGLK-NTAEKYRQLKQQWEMKTEEA 726
            +T   ++K ++DE+ + ++       E + LEE ++ L  N AE+  + K   ++K +  
Sbjct: 974  VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033

Query: 727  DLL-QTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA 785
             ++ + +++     K ++EL+ LK+ +E            ++ A+ + ++ E KM+ A+ 
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-----EQIADLQAQIAELKMQLAK- 1087

Query: 786  ERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNE 845
             +E EL+ A  +LD    + + + KK++E +  +  +  +L+  +      ++Q   + E
Sbjct: 1088 -KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 846  AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNND 905
             +++ ++++E      A  +E   K ++EVT  K+ +  +    +A+  E+ +   Q   
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ--- 1203

Query: 906  SQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEA 965
                ++EL   + + KR   +       + K+   +  E  + GQ     + K    +  
Sbjct: 1204 ---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260

Query: 966  GQRLQKLQEMKEKLGRNVNMRAMNVLTEAE-------ERYNDLMKKKRIVENDKSKILTT 1018
             Q LQ      E+    +N +   +  E E       E     +K  + V +  S++  T
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320

Query: 1019 IEDLDQKKNQALNIA 1033
             E L ++  Q LN++
Sbjct: 1321 QELLQEETRQKLNVS 1335



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 34/145 (23%), Positives = 63/145 (43%), Gaps = 28/145 (19%)

Query: 177  KKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIA 236
            +K AA K++++K+ KLKEI   +E+E     Q  ++        +++ R++E        
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE-------- 1887

Query: 237  YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEK--RKDKET-- 292
                        + EE + +     KLQ EL E  +  +A+  E+  L+   R+  ET  
Sbjct: 1888 -----------EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSF 1936

Query: 293  -----GGILRSLEDALAEAQRVNTK 312
                  G  R +E+A    +  +T+
Sbjct: 1937 VPSRRSGGRRVIENADGSEEETDTR 1961


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  107 bits (268), Expect = 5e-23
 Identities = 201/970 (20%), Positives = 395/970 (40%), Gaps = 158/970 (16%)

Query: 132  CSVGLNVNNPHFLIMQGRITKVLNM--KPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE 189
            C+  L + N  +  +  ++  +L +  +  E+ +  +E   T+  + K     K +E+K 
Sbjct: 830  CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 889

Query: 190  AKLKEIKTILEEEI---TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTK 246
            ++L E K +L+E++   T    + +E R      ++ + EI H     +  +    ED  
Sbjct: 890  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRG 945

Query: 247  VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEA 306
             +   E K+M  +++ L+E+L E +   + L  E    E +        ++ LED +   
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK--------IKKLEDEILVM 997

Query: 307  QRVNTKSQSAFDLKKK-------NLACEESKRKELEK------NMVEDSKTLAAKEKEVK 353
               N K      L ++       NLA EE K K L K      +M+ + +    KE++ +
Sbjct: 998  DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057

Query: 354  KITDGLHALQEASNKD-AEALAAAQQHFNAVSAGLSSNEDGAEATLA--GQMMACKNDIS 410
            +  + L    E    D  E +A  Q     +   L+  E+  +A LA     +A KN+  
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117

Query: 411  KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVK-RLKEKLE--AEMKK 467
            K   + ++ +  +   Q++L +++A   K +   R   E LEA+K  L++ L+  A  ++
Sbjct: 1118 K---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174

Query: 468  LNYEENKEESLL-----EKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCV 522
            L  +  +E ++L     E+ R     +  +++ +   +         +K  + N ++N  
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-- 1232

Query: 523  KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
                      K T      +L AGE          V G+   E  E K++     + ++ 
Sbjct: 1233 ----------KQTLEKENADL-AGE--------LRVLGQAKQE-VEHKKKKLEAQVQELQ 1272

Query: 583  ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD 642
            ++C   E  R   N    D VH          +LQ  +E V G     +           
Sbjct: 1273 SKCSDGERARAELN----DKVH----------KLQNEVESVTGMLNEAEG---------- 1308

Query: 643  KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD-VQDELRIKEN---ELRAL 698
                 + + L  DV               AS+ ++ Q+ ++ +Q+E R K N   +LR L
Sbjct: 1309 -----KAIKLAKDV---------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348

Query: 699  EEELAGLKNTAEKYRQLKQQWE--MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
            EEE   L++  ++  + KQ  E  + T    L  +K +   +    E L+  KK  ++  
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408

Query: 757  ETLKNTKEIQRKAEEKYEVLENKMKN------AEAERERE----LKDAQKKLDCAKTKAD 806
            E L    E +  A +K E  +N+++        + + +R+    L+  Q+K D    +  
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468

Query: 807  ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAK 863
              S K  +++   EA   E  E + +  S  + LE   EA +  E   +++ AE   +  
Sbjct: 1469 NISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525

Query: 864  NKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK--------ELDH 915
            +K+ V K   E+ K K  +  Q   +K +  E+    +   D++L+++        + + 
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585

Query: 916  NISKHKREAEDGAAKVSKMLKDYDW------------INAERHLFGQPNS---AYDFKTN 960
            ++     + E+   ++ + L +Y+               A++ L G         D    
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645

Query: 961  NPKEAGQRLQKLQ-EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTI 1019
              +EA ++L+KLQ +MK+      + RA      A  + N+  KK + +E D  ++   +
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE--KKAKSLEADLMQLQEDL 1703

Query: 1020 EDLDQKKNQA 1029
               ++ + QA
Sbjct: 1704 AAAERARKQA 1713



 Score =  103 bits (257), Expect = 1e-21
 Identities = 148/737 (20%), Positives = 306/737 (41%), Gaps = 111/737 (15%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
            E+  A+L +    L+ E+      L E     +   K+ +++  LS      Q LL E+T
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI---KLAKDVASLSSQLQDTQELLQEET 1335

Query: 246  --KVRSAEELKEMQDKVIKLQEELSEN-------DKKIKALNHEIEELEKRKDKETGGIL 296
              K+  + +L++++++   LQ++L E        ++ I  LN ++ +  K+K ++    +
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD-SKKKLQDFASTV 1394

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
             +LE+     Q+        ++ K    A    K ++ +  + ++   L       +++ 
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEK----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450

Query: 357  DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
              L    E   +  + L A +++   +S+  +   D AEA  A +       +++A  EA
Sbjct: 1451 SNL----EKKQRKFDQLLAEEKN---ISSKYADERDRAEAE-AREKETKALSLARALEEA 1502

Query: 417  KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEE 476
             +A+ +L+   + LK +  ++        K+   LE  KR  E    EMK    EE ++E
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT-QLEELEDE 1561

Query: 477  SLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTS 536
                +  +L     RL+   +AL  +F     A  +  +   R   + L      ++D  
Sbjct: 1562 LQATEDAKL-----RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 537  ATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQN 596
               AL   A ++L   + D E+     ++     R   I  L K+ A+            
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKG----REEAIKQLRKLQAQ------------ 1660

Query: 597  LVGPDNVHVALSLVEYKPELQKAM---EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLG 653
                        + +++ EL+ A    + +F T       +N KK            +L 
Sbjct: 1661 ------------MKDFQRELEDARASRDEIFATA-----KENEKKAK----------SLE 1693

Query: 654  GDVFDPHGTLSGGARSQAASILTKFQELKD-----------VQDELRIKENELRALEEEL 702
             D+      L+   R++  + L K +EL +           +QDE R  E  +  LEEEL
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752

Query: 703  ----AGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEET 758
                  ++  +++ R+  QQ E  + E    ++  Q++   +QQ E              
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE-------------- 1798

Query: 759  LKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQE 818
             +  KE++ K  E    +++K K+  A  E ++   +++++    +  A++K +K+K ++
Sbjct: 1799 -RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857

Query: 819  VEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAKNKESVNKAQEEV 875
            ++ I L++E+ ++    YK+Q E  N  +K  + Q+E    E   +  N+  + +  +E 
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917

Query: 876  TKQKEVITAQDTVIKAK 892
            T+  E +  +   +K+K
Sbjct: 1918 TESNEAMGREVNALKSK 1934



 Score =  101 bits (251), Expect = 5e-21
 Identities = 157/815 (19%), Positives = 347/815 (42%), Gaps = 89/815 (10%)

Query: 178  KIAAQKTIEKKEAKLKEIK---TILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY 234
            K A  +     EA+++E++       EE+T  +++ K  +++ L+  K   E E+     
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENAD--- 1242

Query: 235  IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGG 294
            +A +  +    K     + K+++ +V +LQ + S+ ++    LN ++ +L+   +  TG 
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG- 1301

Query: 295  ILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKK 354
                L +A  +A ++            K++A   S+ ++ ++ + E+++       ++++
Sbjct: 1302 ---MLNEAEGKAIKL-----------AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 355  ITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQT 414
            + +  ++LQ+  +++ EA    ++H + ++  LS ++         ++    + +   + 
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK--------KLQDFASTVEALEE 1399

Query: 415  EAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV-------KRLKEKLEAEMKK 467
              K+ Q ++++  Q+ + K A   K++    + Q+ L+ +       ++L   LE + +K
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459

Query: 468  LNY---EENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKG 524
             +    EE    S     R  +    R KET    LAR        K+  +  N+  +K 
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKA 1518

Query: 525  LVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISAR 584
             +  L+S KD       EL   +R     ++   T  + LE  EL+         +++ +
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQ 1577

Query: 585  CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKR 644
             +  +  R   +L   D  +      E + +LQ+ +   + T    +    A   A  K+
Sbjct: 1578 ALKGQFER---DLQARDEQNE-----EKRRQLQRQLH-EYETELEDERKQRALAAAAKKK 1628

Query: 645  IMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENELRALEEE 701
                   L GD+ D           R +A   L K Q ++KD Q EL     + RA  +E
Sbjct: 1629 -------LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE----DARASRDE 1677

Query: 702  LAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTI-EESEETLK 760
            +       EK        + K+ EADL+Q +   ++  + +++ D  K+ + EE   +L 
Sbjct: 1678 IFATAKENEK--------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729

Query: 761  NTKEIQ---RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQ 817
                +Q   R+ E +   LE +++  +   E  + D  +K   A  +A+  S ++  ++ 
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRK---ATQQAEQLSNELATERS 1785

Query: 818  EVEAITLELEELKREHTSYKQQLEAVNEAIKS-YESQIEVMAAEVAKNKESVNKAQEEVT 876
              +      ++L+R++   + +L  +  A+KS ++S I  + A++A+ +E V +   E  
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 877  KQKEVITAQDTVIKAKYAEVA-------KHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
               + +  +D  +K    +V        ++KEQ      ++K+L   + + + E++   A
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 930  KVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKE 964
               K+ ++ D         G+  +A   K     E
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 188/933 (20%), Positives = 373/933 (39%), Gaps = 120/933 (12%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE-HLSRLYIAYQFLLAE- 243
            E+K   L ++K   E  I+    +LK+E  S  E +K+ R++E   S  +     L A+ 
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085

Query: 244  -DTKVRSAEELKEMQDKVIKLQEELSEND---KKIKALNHEIEELEKRKDKETGG---IL 296
             + K++ A++ +E+Q  + +L +E+++ +   KKI+ L   I +L++  D E        
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
            +   D   E + + T+ +   D    + A ++  R + E+ +    K L   ++E +   
Sbjct: 1146 KQKRDLGEELEALKTELEDTLD----STATQQELRAKREQEVTVLKKAL---DEETRSHE 1198

Query: 357  DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE---ATLAGQMMACKNDISKAQ 413
              +  +++   +  E L    + F    A L  N+   E   A LAG++      + +A+
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV----LGQAK 1254

Query: 414  TEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKKLN 469
             E +  + KL+   QEL++K ++ ++    ++    K Q  +E+V  +  + E +  KL 
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 470  YEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYK---DPEKNWNRNCVKGLV 526
             +     S L+  ++L ++  R K      L +    R + +   D E    +N  + + 
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374

Query: 527  ASLISVKDTS------ATTALELVAGERLYNVVVDT---------------EVTGKKL-- 563
               I + D+       A+T   L  G++ +   ++                E T  +L  
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434

Query: 564  ------------------LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHV 605
                              LE+ + K    +     IS++         A+     +    
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE---AREKETK 1491

Query: 606  ALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSG 665
            ALSL     E  +A E           ++   K+   K  M   V+   DV      L  
Sbjct: 1492 ALSLARALEEALEAKE----------ELERTNKML--KAEMEDLVSSKDDVGKNVHELEK 1539

Query: 666  GARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEE 725
              R+    +     +L++++DEL+  E+    LE  +  LK   E  R L+ + E   E+
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEK 1597

Query: 726  ADLLQTKLQQ-----SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
               LQ +L +         KQ+    A KK +E   + L+   +   K  E+      K+
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657

Query: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV--------------EAITLEL 826
            +    + +REL+DA+   D     A  + KK K  + ++              +   LE 
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717

Query: 827  EELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK---NKESVNKAQEEVTKQ----- 878
            EEL  E  S      A+ +  +  E++I  +  E+ +   N E+++    + T+Q     
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 879  KEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNI-SKHKREAEDGAAKVSKMLKD 937
             E+ T + T  K + A   + + QN + + K+ E++  + SK K       AK++++ + 
Sbjct: 1778 NELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836

Query: 938  YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNV---LTEA 994
             +    E+    +     D K        +  +K+ E  ++     N R   +   L EA
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1896

Query: 995  EERYNDLMKKKRIVENDKSKILTTIEDLDQKKN 1027
            EE    +   +R ++ +  +   + E + ++ N
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMGREVN 1929



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 179/896 (19%), Positives = 354/896 (39%), Gaps = 99/896 (11%)

Query: 204  TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKL 263
            T  +  L+EER   L+   V+   + + R Y+A +       ++ + + ++      +KL
Sbjct: 779  TGVLAHLEEERD--LKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKL 836

Query: 264  QE----ELSENDKKIKALNHEIEELEKRKDK--ETGGILRSLEDALAEAQRVNTKSQSAF 317
            +      L    K +  +  + EE++ ++D+  +T    +  E+ L E ++ +++     
Sbjct: 837  RNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK 896

Query: 318  DLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQ 377
            +L ++ L  E     E E+  V     LAAK++E+++I   + A  E      + L A +
Sbjct: 897  NLLQEQLQAETELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952

Query: 378  QHFNAVSAGLSSN---EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
            +        L      E+ A   L  + +  +  I K + E      +     +E K  +
Sbjct: 953  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012

Query: 435  AEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESL---LEK-RRQLSRDIG 490
              +  + +   +++E  + + +LK K E+ + +L     KEE     LEK +R+L  D  
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072

Query: 491  RLKETYEALLARFPNLR-------------FAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
               E    L A+   L+              A  D E     N +K +      + D   
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 538  TTALELVA-----------GERLYNVVVDTEVTGKKLLERGEL--KRRYTIIPLNKISAR 584
                E  A           GE L  +  + E T      + EL  KR   +  L K    
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 585  CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT--TFVCDNMDNAKKVAF- 641
                   +V +  +   +      L E   + ++A   +     T   +N D A ++   
Sbjct: 1193 ETRSHEAQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250

Query: 642  ---DKRIMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENEL 695
                + +  +   L   V +     S G  AR++    + K Q E++ V   L   E + 
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310

Query: 696  RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES 755
              L +++A L +  +  ++L Q+   +T +   + TKL+Q      +EE ++L+  ++E 
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQE---ETRQKLNVSTKLRQ-----LEEERNSLQDQLDEE 1362

Query: 756  EETLKN------TKEIQ-RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADAS 808
             E  +N      T  IQ   +++K +   + ++  E  ++R  K+ +      + KA A 
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422

Query: 809  SKKMKEK---QQEVEAITLELE-------ELKREHTSYKQQLEAVNEAIKSYESQIEVMA 858
             K  K K   QQE++ + ++L+        L+++   + Q L         Y  + +   
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482

Query: 859  AEVAKNKE----SVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD 914
            AE A+ KE    S+ +A EE  + KE +   + ++KA+  ++   K+        + +  
Sbjct: 1483 AE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-------VGKNV 1534

Query: 915  HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974
            H + K KR  E    ++   L++      E  L    ++    + N     GQ  + LQ 
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEE-----LEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589

Query: 975  MKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
              E+       +    L E E    D  K++ +    K K+   ++DL+ + + A+
Sbjct: 1590 RDEQ-NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 74/375 (19%), Positives = 168/375 (44%), Gaps = 29/375 (7%)

Query: 675  LTKFQELKDVQDELRIKEN-------ELRALEEELAGLK-NTAEKYRQLKQQWEMKTEEA 726
            +T   ++K ++DE+ + ++       E + LEE ++ L  N AE+  + K   ++K +  
Sbjct: 981  VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040

Query: 727  DLL-QTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA 785
             ++ + +++     K ++EL+ LK+ +E            ++ A+ + ++ E KM+ A+ 
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-----EQIADLQAQIAELKMQLAK- 1094

Query: 786  ERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNE 845
             +E EL+ A  +LD    + + + KK++E +  +  +  +L+  +      ++Q   + E
Sbjct: 1095 -KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 846  AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNND 905
             +++ ++++E      A  +E   K ++EVT  K+ +  +    +A+  E+ +   Q   
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ--- 1210

Query: 906  SQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEA 965
                ++EL   + + KR   +       + K+   +  E  + GQ     + K    +  
Sbjct: 1211 ---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267

Query: 966  GQRLQKLQEMKEKLGRNVNMRAMNVLTEAE-------ERYNDLMKKKRIVENDKSKILTT 1018
             Q LQ      E+    +N +   +  E E       E     +K  + V +  S++  T
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327

Query: 1019 IEDLDQKKNQALNIA 1033
             E L ++  Q LN++
Sbjct: 1328 QELLQEETRQKLNVS 1342



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 34/145 (23%), Positives = 63/145 (43%), Gaps = 28/145 (19%)

Query: 177  KKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIA 236
            +K AA K++++K+ KLKEI   +E+E     Q  ++        +++ R++E        
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE-------- 1894

Query: 237  YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEK--RKDKET-- 292
                        + EE + +     KLQ EL E  +  +A+  E+  L+   R+  ET  
Sbjct: 1895 -----------EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSF 1943

Query: 293  -----GGILRSLEDALAEAQRVNTK 312
                  G  R +E+A    +  +T+
Sbjct: 1944 VPSRRSGGRRVIENADGSEEETDTR 1968


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  107 bits (268), Expect = 5e-23
 Identities = 201/970 (20%), Positives = 395/970 (40%), Gaps = 158/970 (16%)

Query: 132  CSVGLNVNNPHFLIMQGRITKVLNM--KPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE 189
            C+  L + N  +  +  ++  +L +  +  E+ +  +E   T+  + K     K +E+K 
Sbjct: 830  CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 889

Query: 190  AKLKEIKTILEEEI---TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTK 246
            ++L E K +L+E++   T    + +E R      ++ + EI H     +  +    ED  
Sbjct: 890  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRG 945

Query: 247  VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEA 306
             +   E K+M  +++ L+E+L E +   + L  E    E +        ++ LED +   
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK--------IKKLEDEILVM 997

Query: 307  QRVNTKSQSAFDLKKK-------NLACEESKRKELEK------NMVEDSKTLAAKEKEVK 353
               N K      L ++       NLA EE K K L K      +M+ + +    KE++ +
Sbjct: 998  DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057

Query: 354  KITDGLHALQEASNKD-AEALAAAQQHFNAVSAGLSSNEDGAEATLA--GQMMACKNDIS 410
            +  + L    E    D  E +A  Q     +   L+  E+  +A LA     +A KN+  
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117

Query: 411  KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVK-RLKEKLE--AEMKK 467
            K   + ++ +  +   Q++L +++A   K +   R   E LEA+K  L++ L+  A  ++
Sbjct: 1118 K---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174

Query: 468  LNYEENKEESLL-----EKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCV 522
            L  +  +E ++L     E+ R     +  +++ +   +         +K  + N ++N  
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-- 1232

Query: 523  KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
                      K T      +L AGE          V G+   E  E K++     + ++ 
Sbjct: 1233 ----------KQTLEKENADL-AGE--------LRVLGQAKQE-VEHKKKKLEAQVQELQ 1272

Query: 583  ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD 642
            ++C   E  R   N    D VH          +LQ  +E V G     +           
Sbjct: 1273 SKCSDGERARAELN----DKVH----------KLQNEVESVTGMLNEAEG---------- 1308

Query: 643  KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD-VQDELRIKEN---ELRAL 698
                 + + L  DV               AS+ ++ Q+ ++ +Q+E R K N   +LR L
Sbjct: 1309 -----KAIKLAKDV---------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348

Query: 699  EEELAGLKNTAEKYRQLKQQWE--MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
            EEE   L++  ++  + KQ  E  + T    L  +K +   +    E L+  KK  ++  
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408

Query: 757  ETLKNTKEIQRKAEEKYEVLENKMKN------AEAERERE----LKDAQKKLDCAKTKAD 806
            E L    E +  A +K E  +N+++        + + +R+    L+  Q+K D    +  
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468

Query: 807  ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAK 863
              S K  +++   EA   E  E + +  S  + LE   EA +  E   +++ AE   +  
Sbjct: 1469 NISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525

Query: 864  NKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK--------ELDH 915
            +K+ V K   E+ K K  +  Q   +K +  E+    +   D++L+++        + + 
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585

Query: 916  NISKHKREAEDGAAKVSKMLKDYDW------------INAERHLFGQPNS---AYDFKTN 960
            ++     + E+   ++ + L +Y+               A++ L G         D    
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645

Query: 961  NPKEAGQRLQKLQ-EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTI 1019
              +EA ++L+KLQ +MK+      + RA      A  + N+  KK + +E D  ++   +
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE--KKAKSLEADLMQLQEDL 1703

Query: 1020 EDLDQKKNQA 1029
               ++ + QA
Sbjct: 1704 AAAERARKQA 1713



 Score =  103 bits (257), Expect = 1e-21
 Identities = 148/737 (20%), Positives = 306/737 (41%), Gaps = 111/737 (15%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
            E+  A+L +    L+ E+      L E     +   K+ +++  LS      Q LL E+T
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI---KLAKDVASLSSQLQDTQELLQEET 1335

Query: 246  --KVRSAEELKEMQDKVIKLQEELSEN-------DKKIKALNHEIEELEKRKDKETGGIL 296
              K+  + +L++++++   LQ++L E        ++ I  LN ++ +  K+K ++    +
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD-SKKKLQDFASTV 1394

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
             +LE+     Q+        ++ K    A    K ++ +  + ++   L       +++ 
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEK----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450

Query: 357  DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
              L    E   +  + L A +++   +S+  +   D AEA  A +       +++A  EA
Sbjct: 1451 SNL----EKKQRKFDQLLAEEKN---ISSKYADERDRAEAE-AREKETKALSLARALEEA 1502

Query: 417  KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEE 476
             +A+ +L+   + LK +  ++        K+   LE  KR  E    EMK    EE ++E
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT-QLEELEDE 1561

Query: 477  SLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTS 536
                +  +L     RL+   +AL  +F     A  +  +   R   + L      ++D  
Sbjct: 1562 LQATEDAKL-----RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 537  ATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQN 596
               AL   A ++L   + D E+     ++     R   I  L K+ A+            
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKG----REEAIKQLRKLQAQ------------ 1660

Query: 597  LVGPDNVHVALSLVEYKPELQKAM---EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLG 653
                        + +++ EL+ A    + +F T       +N KK            +L 
Sbjct: 1661 ------------MKDFQRELEDARASRDEIFATA-----KENEKKAK----------SLE 1693

Query: 654  GDVFDPHGTLSGGARSQAASILTKFQELKD-----------VQDELRIKENELRALEEEL 702
             D+      L+   R++  + L K +EL +           +QDE R  E  +  LEEEL
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752

Query: 703  ----AGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEET 758
                  ++  +++ R+  QQ E  + E    ++  Q++   +QQ E              
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE-------------- 1798

Query: 759  LKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQE 818
             +  KE++ K  E    +++K K+  A  E ++   +++++    +  A++K +K+K ++
Sbjct: 1799 -RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857

Query: 819  VEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAKNKESVNKAQEEV 875
            ++ I L++E+ ++    YK+Q E  N  +K  + Q+E    E   +  N+  + +  +E 
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917

Query: 876  TKQKEVITAQDTVIKAK 892
            T+  E +  +   +K+K
Sbjct: 1918 TESNEAMGREVNALKSK 1934



 Score =  102 bits (255), Expect = 2e-21
 Identities = 157/813 (19%), Positives = 347/813 (42%), Gaps = 89/813 (10%)

Query: 178  KIAAQKTIEKKEAKLKEIK---TILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY 234
            K A  +     EA+++E++       EE+T  +++ K  +++ L+  K   E E+     
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENAD--- 1242

Query: 235  IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGG 294
            +A +  +    K     + K+++ +V +LQ + S+ ++    LN ++ +L+   +  TG 
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG- 1301

Query: 295  ILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKK 354
                L +A  +A ++            K++A   S+ ++ ++ + E+++       ++++
Sbjct: 1302 ---MLNEAEGKAIKL-----------AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 355  ITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQT 414
            + +  ++LQ+  +++ EA    ++H + ++  LS ++         ++    + +   + 
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK--------KLQDFASTVEALEE 1399

Query: 415  EAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV-------KRLKEKLEAEMKK 467
              K+ Q ++++  Q+ + K A   K++    + Q+ L+ +       ++L   LE + +K
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459

Query: 468  LNY---EENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKG 524
             +    EE    S     R  +    R KET    LAR        K+  +  N+  +K 
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKA 1518

Query: 525  LVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISAR 584
             +  L+S KD       EL   +R     ++   T  + LE  EL+         +++ +
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQ 1577

Query: 585  CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKR 644
             +  +  R   +L   D  +      E + +LQ+ +   + T    +    A   A  K+
Sbjct: 1578 ALKGQFER---DLQARDEQNE-----EKRRQLQRQLH-EYETELEDERKQRALAAAAKKK 1628

Query: 645  IMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENELRALEEE 701
                   L GD+ D           R +A   L K Q ++KD Q EL     + RA  +E
Sbjct: 1629 -------LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE----DARASRDE 1677

Query: 702  LAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTI-EESEETLK 760
            +       EK        + K+ EADL+Q +   ++  + +++ D  K+ + EE   +L 
Sbjct: 1678 IFATAKENEK--------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729

Query: 761  NTKEIQ---RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQ 817
                +Q   R+ E +   LE +++  +   E  + D  +K   A  +A+  S ++  ++ 
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRK---ATQQAEQLSNELATERS 1785

Query: 818  EVEAITLELEELKREHTSYKQQLEAVNEAIKS-YESQIEVMAAEVAKNKESVNKAQEEVT 876
              +      ++L+R++   + +L  +  A+KS ++S I  + A++A+ +E V +   E  
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 877  KQKEVITAQDTVIKAKYAEVA-------KHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
               + +  +D  +K    +V        ++KEQ      ++K+L   + + + E++   A
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 930  KVSKMLKDYDWINAERHLFGQPNSAYDFKTNNP 962
               K+ ++ D         G+  +A   K   P
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRGP 1938



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 188/933 (20%), Positives = 373/933 (39%), Gaps = 120/933 (12%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE-HLSRLYIAYQFLLAE- 243
            E+K   L ++K   E  I+    +LK+E  S  E +K+ R++E   S  +     L A+ 
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085

Query: 244  -DTKVRSAEELKEMQDKVIKLQEELSEND---KKIKALNHEIEELEKRKDKETGG---IL 296
             + K++ A++ +E+Q  + +L +E+++ +   KKI+ L   I +L++  D E        
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
            +   D   E + + T+ +   D    + A ++  R + E+ +    K L   ++E +   
Sbjct: 1146 KQKRDLGEELEALKTELEDTLD----STATQQELRAKREQEVTVLKKAL---DEETRSHE 1198

Query: 357  DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE---ATLAGQMMACKNDISKAQ 413
              +  +++   +  E L    + F    A L  N+   E   A LAG++      + +A+
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV----LGQAK 1254

Query: 414  TEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKKLN 469
             E +  + KL+   QEL++K ++ ++    ++    K Q  +E+V  +  + E +  KL 
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 470  YEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYK---DPEKNWNRNCVKGLV 526
             +     S L+  ++L ++  R K      L +    R + +   D E    +N  + + 
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374

Query: 527  ASLISVKDTS------ATTALELVAGERLYNVVVDT---------------EVTGKKL-- 563
               I + D+       A+T   L  G++ +   ++                E T  +L  
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434

Query: 564  ------------------LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHV 605
                              LE+ + K    +     IS++         A+     +    
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE---AREKETK 1491

Query: 606  ALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSG 665
            ALSL     E  +A E           ++   K+   K  M   V+   DV      L  
Sbjct: 1492 ALSLARALEEALEAKE----------ELERTNKML--KAEMEDLVSSKDDVGKNVHELEK 1539

Query: 666  GARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEE 725
              R+    +     +L++++DEL+  E+    LE  +  LK   E  R L+ + E   E+
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEK 1597

Query: 726  ADLLQTKLQQ-----SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
               LQ +L +         KQ+    A KK +E   + L+   +   K  E+      K+
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657

Query: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV--------------EAITLEL 826
            +    + +REL+DA+   D     A  + KK K  + ++              +   LE 
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717

Query: 827  EELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK---NKESVNKAQEEVTKQ----- 878
            EEL  E  S      A+ +  +  E++I  +  E+ +   N E+++    + T+Q     
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 879  KEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNI-SKHKREAEDGAAKVSKMLKD 937
             E+ T + T  K + A   + + QN + + K+ E++  + SK K       AK++++ + 
Sbjct: 1778 NELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836

Query: 938  YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNV---LTEA 994
             +    E+    +     D K        +  +K+ E  ++     N R   +   L EA
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1896

Query: 995  EERYNDLMKKKRIVENDKSKILTTIEDLDQKKN 1027
            EE    +   +R ++ +  +   + E + ++ N
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMGREVN 1929



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 179/896 (19%), Positives = 354/896 (39%), Gaps = 99/896 (11%)

Query: 204  TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKL 263
            T  +  L+EER   L+   V+   + + R Y+A +       ++ + + ++      +KL
Sbjct: 779  TGVLAHLEEERD--LKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKL 836

Query: 264  QE----ELSENDKKIKALNHEIEELEKRKDK--ETGGILRSLEDALAEAQRVNTKSQSAF 317
            +      L    K +  +  + EE++ ++D+  +T    +  E+ L E ++ +++     
Sbjct: 837  RNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK 896

Query: 318  DLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQ 377
            +L ++ L  E     E E+  V     LAAK++E+++I   + A  E      + L A +
Sbjct: 897  NLLQEQLQAETELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952

Query: 378  QHFNAVSAGLSSN---EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
            +        L      E+ A   L  + +  +  I K + E      +     +E K  +
Sbjct: 953  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012

Query: 435  AEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESL---LEK-RRQLSRDIG 490
              +  + +   +++E  + + +LK K E+ + +L     KEE     LEK +R+L  D  
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072

Query: 491  RLKETYEALLARFPNLR-------------FAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
               E    L A+   L+              A  D E     N +K +      + D   
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 538  TTALELVA-----------GERLYNVVVDTEVTGKKLLERGEL--KRRYTIIPLNKISAR 584
                E  A           GE L  +  + E T      + EL  KR   +  L K    
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 585  CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT--TFVCDNMDNAKKVAF- 641
                   +V +  +   +      L E   + ++A   +     T   +N D A ++   
Sbjct: 1193 ETRSHEAQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250

Query: 642  ---DKRIMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENEL 695
                + +  +   L   V +     S G  AR++    + K Q E++ V   L   E + 
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310

Query: 696  RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES 755
              L +++A L +  +  ++L Q+   +T +   + TKL+Q      +EE ++L+  ++E 
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQE---ETRQKLNVSTKLRQ-----LEEERNSLQDQLDEE 1362

Query: 756  EETLKN------TKEIQ-RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADAS 808
             E  +N      T  IQ   +++K +   + ++  E  ++R  K+ +      + KA A 
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422

Query: 809  SKKMKEK---QQEVEAITLELE-------ELKREHTSYKQQLEAVNEAIKSYESQIEVMA 858
             K  K K   QQE++ + ++L+        L+++   + Q L         Y  + +   
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482

Query: 859  AEVAKNKE----SVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD 914
            AE A+ KE    S+ +A EE  + KE +   + ++KA+  ++   K+        + +  
Sbjct: 1483 AE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-------VGKNV 1534

Query: 915  HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974
            H + K KR  E    ++   L++      E  L    ++    + N     GQ  + LQ 
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEE-----LEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589

Query: 975  MKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
              E+       +    L E E    D  K++ +    K K+   ++DL+ + + A+
Sbjct: 1590 RDEQ-NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 74/375 (19%), Positives = 168/375 (44%), Gaps = 29/375 (7%)

Query: 675  LTKFQELKDVQDELRIKEN-------ELRALEEELAGLK-NTAEKYRQLKQQWEMKTEEA 726
            +T   ++K ++DE+ + ++       E + LEE ++ L  N AE+  + K   ++K +  
Sbjct: 981  VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040

Query: 727  DLL-QTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA 785
             ++ + +++     K ++EL+ LK+ +E            ++ A+ + ++ E KM+ A+ 
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-----EQIADLQAQIAELKMQLAK- 1094

Query: 786  ERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNE 845
             +E EL+ A  +LD    + + + KK++E +  +  +  +L+  +      ++Q   + E
Sbjct: 1095 -KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 846  AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNND 905
             +++ ++++E      A  +E   K ++EVT  K+ +  +    +A+  E+ +   Q   
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ--- 1210

Query: 906  SQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEA 965
                ++EL   + + KR   +       + K+   +  E  + GQ     + K    +  
Sbjct: 1211 ---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267

Query: 966  GQRLQKLQEMKEKLGRNVNMRAMNVLTEAE-------ERYNDLMKKKRIVENDKSKILTT 1018
             Q LQ      E+    +N +   +  E E       E     +K  + V +  S++  T
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327

Query: 1019 IEDLDQKKNQALNIA 1033
             E L ++  Q LN++
Sbjct: 1328 QELLQEETRQKLNVS 1342



 Score = 34.7 bits (78), Expect = 0.56
 Identities = 26/111 (23%), Positives = 50/111 (45%), Gaps = 19/111 (17%)

Query: 177  KKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIA 236
            +K AA K++++K+ KLKEI   +E+E     Q  ++        +++ R++E        
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE-------- 1894

Query: 237  YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKR 287
                        + EE + +     KLQ EL E  +  +A+  E+  L+ +
Sbjct: 1895 -----------EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  107 bits (268), Expect = 5e-23
 Identities = 201/970 (20%), Positives = 395/970 (40%), Gaps = 158/970 (16%)

Query: 132  CSVGLNVNNPHFLIMQGRITKVLNM--KPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE 189
            C+  L + N  +  +  ++  +L +  +  E+ +  +E   T+  + K     K +E+K 
Sbjct: 823  CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 882

Query: 190  AKLKEIKTILEEEI---TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTK 246
            ++L E K +L+E++   T    + +E R      ++ + EI H     +  +    ED  
Sbjct: 883  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRG 938

Query: 247  VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEA 306
             +   E K+M  +++ L+E+L E +   + L  E    E +        ++ LED +   
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK--------IKKLEDEILVM 990

Query: 307  QRVNTKSQSAFDLKKK-------NLACEESKRKELEK------NMVEDSKTLAAKEKEVK 353
               N K      L ++       NLA EE K K L K      +M+ + +    KE++ +
Sbjct: 991  DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050

Query: 354  KITDGLHALQEASNKD-AEALAAAQQHFNAVSAGLSSNEDGAEATLA--GQMMACKNDIS 410
            +  + L    E    D  E +A  Q     +   L+  E+  +A LA     +A KN+  
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110

Query: 411  KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVK-RLKEKLE--AEMKK 467
            K   + ++ +  +   Q++L +++A   K +   R   E LEA+K  L++ L+  A  ++
Sbjct: 1111 K---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167

Query: 468  LNYEENKEESLL-----EKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCV 522
            L  +  +E ++L     E+ R     +  +++ +   +         +K  + N ++N  
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-- 1225

Query: 523  KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
                      K T      +L AGE          V G+   E  E K++     + ++ 
Sbjct: 1226 ----------KQTLEKENADL-AGE--------LRVLGQAKQE-VEHKKKKLEAQVQELQ 1265

Query: 583  ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD 642
            ++C   E  R   N    D VH          +LQ  +E V G     +           
Sbjct: 1266 SKCSDGERARAELN----DKVH----------KLQNEVESVTGMLNEAEG---------- 1301

Query: 643  KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD-VQDELRIKEN---ELRAL 698
                 + + L  DV               AS+ ++ Q+ ++ +Q+E R K N   +LR L
Sbjct: 1302 -----KAIKLAKDV---------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341

Query: 699  EEELAGLKNTAEKYRQLKQQWE--MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
            EEE   L++  ++  + KQ  E  + T    L  +K +   +    E L+  KK  ++  
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401

Query: 757  ETLKNTKEIQRKAEEKYEVLENKMKN------AEAERERE----LKDAQKKLDCAKTKAD 806
            E L    E +  A +K E  +N+++        + + +R+    L+  Q+K D    +  
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461

Query: 807  ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAK 863
              S K  +++   EA   E  E + +  S  + LE   EA +  E   +++ AE   +  
Sbjct: 1462 NISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518

Query: 864  NKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK--------ELDH 915
            +K+ V K   E+ K K  +  Q   +K +  E+    +   D++L+++        + + 
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578

Query: 916  NISKHKREAEDGAAKVSKMLKDYDW------------INAERHLFGQPNS---AYDFKTN 960
            ++     + E+   ++ + L +Y+               A++ L G         D    
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638

Query: 961  NPKEAGQRLQKLQ-EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTI 1019
              +EA ++L+KLQ +MK+      + RA      A  + N+  KK + +E D  ++   +
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE--KKAKSLEADLMQLQEDL 1696

Query: 1020 EDLDQKKNQA 1029
               ++ + QA
Sbjct: 1697 AAAERARKQA 1706



 Score =  103 bits (257), Expect = 1e-21
 Identities = 148/737 (20%), Positives = 306/737 (41%), Gaps = 111/737 (15%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
            E+  A+L +    L+ E+      L E     +   K+ +++  LS      Q LL E+T
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI---KLAKDVASLSSQLQDTQELLQEET 1328

Query: 246  --KVRSAEELKEMQDKVIKLQEELSEN-------DKKIKALNHEIEELEKRKDKETGGIL 296
              K+  + +L++++++   LQ++L E        ++ I  LN ++ +  K+K ++    +
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD-SKKKLQDFASTV 1387

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
             +LE+     Q+        ++ K    A    K ++ +  + ++   L       +++ 
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEK----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443

Query: 357  DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
              L    E   +  + L A +++   +S+  +   D AEA  A +       +++A  EA
Sbjct: 1444 SNL----EKKQRKFDQLLAEEKN---ISSKYADERDRAEAE-AREKETKALSLARALEEA 1495

Query: 417  KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEE 476
             +A+ +L+   + LK +  ++        K+   LE  KR  E    EMK    EE ++E
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT-QLEELEDE 1554

Query: 477  SLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTS 536
                +  +L     RL+   +AL  +F     A  +  +   R   + L      ++D  
Sbjct: 1555 LQATEDAKL-----RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 537  ATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQN 596
               AL   A ++L   + D E+     ++     R   I  L K+ A+            
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKG----REEAIKQLRKLQAQ------------ 1653

Query: 597  LVGPDNVHVALSLVEYKPELQKAM---EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLG 653
                        + +++ EL+ A    + +F T       +N KK            +L 
Sbjct: 1654 ------------MKDFQRELEDARASRDEIFATA-----KENEKKAK----------SLE 1686

Query: 654  GDVFDPHGTLSGGARSQAASILTKFQELKD-----------VQDELRIKENELRALEEEL 702
             D+      L+   R++  + L K +EL +           +QDE R  E  +  LEEEL
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745

Query: 703  ----AGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEET 758
                  ++  +++ R+  QQ E  + E    ++  Q++   +QQ E              
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE-------------- 1791

Query: 759  LKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQE 818
             +  KE++ K  E    +++K K+  A  E ++   +++++    +  A++K +K+K ++
Sbjct: 1792 -RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850

Query: 819  VEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAKNKESVNKAQEEV 875
            ++ I L++E+ ++    YK+Q E  N  +K  + Q+E    E   +  N+  + +  +E 
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910

Query: 876  TKQKEVITAQDTVIKAK 892
            T+  E +  +   +K+K
Sbjct: 1911 TESNEAMGREVNALKSK 1927



 Score =  102 bits (255), Expect = 2e-21
 Identities = 157/813 (19%), Positives = 347/813 (42%), Gaps = 89/813 (10%)

Query: 178  KIAAQKTIEKKEAKLKEIK---TILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY 234
            K A  +     EA+++E++       EE+T  +++ K  +++ L+  K   E E+     
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENAD--- 1235

Query: 235  IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGG 294
            +A +  +    K     + K+++ +V +LQ + S+ ++    LN ++ +L+   +  TG 
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG- 1294

Query: 295  ILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKK 354
                L +A  +A ++            K++A   S+ ++ ++ + E+++       ++++
Sbjct: 1295 ---MLNEAEGKAIKL-----------AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 355  ITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQT 414
            + +  ++LQ+  +++ EA    ++H + ++  LS ++         ++    + +   + 
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK--------KLQDFASTVEALEE 1392

Query: 415  EAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV-------KRLKEKLEAEMKK 467
              K+ Q ++++  Q+ + K A   K++    + Q+ L+ +       ++L   LE + +K
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452

Query: 468  LNY---EENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKG 524
             +    EE    S     R  +    R KET    LAR        K+  +  N+  +K 
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKA 1511

Query: 525  LVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISAR 584
             +  L+S KD       EL   +R     ++   T  + LE  EL+         +++ +
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQ 1570

Query: 585  CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKR 644
             +  +  R   +L   D  +      E + +LQ+ +   + T    +    A   A  K+
Sbjct: 1571 ALKGQFER---DLQARDEQNE-----EKRRQLQRQLH-EYETELEDERKQRALAAAAKKK 1621

Query: 645  IMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENELRALEEE 701
                   L GD+ D           R +A   L K Q ++KD Q EL     + RA  +E
Sbjct: 1622 -------LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE----DARASRDE 1670

Query: 702  LAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTI-EESEETLK 760
            +       EK        + K+ EADL+Q +   ++  + +++ D  K+ + EE   +L 
Sbjct: 1671 IFATAKENEK--------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722

Query: 761  NTKEIQ---RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQ 817
                +Q   R+ E +   LE +++  +   E  + D  +K   A  +A+  S ++  ++ 
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRK---ATQQAEQLSNELATERS 1778

Query: 818  EVEAITLELEELKREHTSYKQQLEAVNEAIKS-YESQIEVMAAEVAKNKESVNKAQEEVT 876
              +      ++L+R++   + +L  +  A+KS ++S I  + A++A+ +E V +   E  
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 877  KQKEVITAQDTVIKAKYAEVA-------KHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
               + +  +D  +K    +V        ++KEQ      ++K+L   + + + E++   A
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 930  KVSKMLKDYDWINAERHLFGQPNSAYDFKTNNP 962
               K+ ++ D         G+  +A   K   P
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRGP 1931



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 188/933 (20%), Positives = 373/933 (39%), Gaps = 120/933 (12%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE-HLSRLYIAYQFLLAE- 243
            E+K   L ++K   E  I+    +LK+E  S  E +K+ R++E   S  +     L A+ 
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078

Query: 244  -DTKVRSAEELKEMQDKVIKLQEELSEND---KKIKALNHEIEELEKRKDKETGG---IL 296
             + K++ A++ +E+Q  + +L +E+++ +   KKI+ L   I +L++  D E        
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
            +   D   E + + T+ +   D    + A ++  R + E+ +    K L   ++E +   
Sbjct: 1139 KQKRDLGEELEALKTELEDTLD----STATQQELRAKREQEVTVLKKAL---DEETRSHE 1191

Query: 357  DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE---ATLAGQMMACKNDISKAQ 413
              +  +++   +  E L    + F    A L  N+   E   A LAG++      + +A+
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV----LGQAK 1247

Query: 414  TEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKKLN 469
             E +  + KL+   QEL++K ++ ++    ++    K Q  +E+V  +  + E +  KL 
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 470  YEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYK---DPEKNWNRNCVKGLV 526
             +     S L+  ++L ++  R K      L +    R + +   D E    +N  + + 
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367

Query: 527  ASLISVKDTS------ATTALELVAGERLYNVVVDT---------------EVTGKKL-- 563
               I + D+       A+T   L  G++ +   ++                E T  +L  
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427

Query: 564  ------------------LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHV 605
                              LE+ + K    +     IS++         A+     +    
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE---AREKETK 1484

Query: 606  ALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSG 665
            ALSL     E  +A E           ++   K+   K  M   V+   DV      L  
Sbjct: 1485 ALSLARALEEALEAKE----------ELERTNKML--KAEMEDLVSSKDDVGKNVHELEK 1532

Query: 666  GARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEE 725
              R+    +     +L++++DEL+  E+    LE  +  LK   E  R L+ + E   E+
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEK 1590

Query: 726  ADLLQTKLQQ-----SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
               LQ +L +         KQ+    A KK +E   + L+   +   K  E+      K+
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650

Query: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV--------------EAITLEL 826
            +    + +REL+DA+   D     A  + KK K  + ++              +   LE 
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710

Query: 827  EELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK---NKESVNKAQEEVTKQ----- 878
            EEL  E  S      A+ +  +  E++I  +  E+ +   N E+++    + T+Q     
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770

Query: 879  KEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNI-SKHKREAEDGAAKVSKMLKD 937
             E+ T + T  K + A   + + QN + + K+ E++  + SK K       AK++++ + 
Sbjct: 1771 NELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829

Query: 938  YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNV---LTEA 994
             +    E+    +     D K        +  +K+ E  ++     N R   +   L EA
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889

Query: 995  EERYNDLMKKKRIVENDKSKILTTIEDLDQKKN 1027
            EE    +   +R ++ +  +   + E + ++ N
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVN 1922



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 179/896 (19%), Positives = 354/896 (39%), Gaps = 99/896 (11%)

Query: 204  TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKL 263
            T  +  L+EER   L+   V+   + + R Y+A +       ++ + + ++      +KL
Sbjct: 772  TGVLAHLEEERD--LKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKL 829

Query: 264  QE----ELSENDKKIKALNHEIEELEKRKDK--ETGGILRSLEDALAEAQRVNTKSQSAF 317
            +      L    K +  +  + EE++ ++D+  +T    +  E+ L E ++ +++     
Sbjct: 830  RNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK 889

Query: 318  DLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQ 377
            +L ++ L  E     E E+  V     LAAK++E+++I   + A  E      + L A +
Sbjct: 890  NLLQEQLQAETELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945

Query: 378  QHFNAVSAGLSSN---EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
            +        L      E+ A   L  + +  +  I K + E      +     +E K  +
Sbjct: 946  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005

Query: 435  AEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESL---LEK-RRQLSRDIG 490
              +  + +   +++E  + + +LK K E+ + +L     KEE     LEK +R+L  D  
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065

Query: 491  RLKETYEALLARFPNLR-------------FAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
               E    L A+   L+              A  D E     N +K +      + D   
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 538  TTALELVA-----------GERLYNVVVDTEVTGKKLLERGEL--KRRYTIIPLNKISAR 584
                E  A           GE L  +  + E T      + EL  KR   +  L K    
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 585  CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT--TFVCDNMDNAKKVAF- 641
                   +V +  +   +      L E   + ++A   +     T   +N D A ++   
Sbjct: 1186 ETRSHEAQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243

Query: 642  ---DKRIMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENEL 695
                + +  +   L   V +     S G  AR++    + K Q E++ V   L   E + 
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303

Query: 696  RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES 755
              L +++A L +  +  ++L Q+   +T +   + TKL+Q      +EE ++L+  ++E 
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQE---ETRQKLNVSTKLRQ-----LEEERNSLQDQLDEE 1355

Query: 756  EETLKN------TKEIQ-RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADAS 808
             E  +N      T  IQ   +++K +   + ++  E  ++R  K+ +      + KA A 
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415

Query: 809  SKKMKEK---QQEVEAITLELE-------ELKREHTSYKQQLEAVNEAIKSYESQIEVMA 858
             K  K K   QQE++ + ++L+        L+++   + Q L         Y  + +   
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475

Query: 859  AEVAKNKE----SVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD 914
            AE A+ KE    S+ +A EE  + KE +   + ++KA+  ++   K+        + +  
Sbjct: 1476 AE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-------VGKNV 1527

Query: 915  HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974
            H + K KR  E    ++   L++      E  L    ++    + N     GQ  + LQ 
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEE-----LEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582

Query: 975  MKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
              E+       +    L E E    D  K++ +    K K+   ++DL+ + + A+
Sbjct: 1583 RDEQ-NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 74/375 (19%), Positives = 168/375 (44%), Gaps = 29/375 (7%)

Query: 675  LTKFQELKDVQDELRIKEN-------ELRALEEELAGLK-NTAEKYRQLKQQWEMKTEEA 726
            +T   ++K ++DE+ + ++       E + LEE ++ L  N AE+  + K   ++K +  
Sbjct: 974  VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033

Query: 727  DLL-QTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA 785
             ++ + +++     K ++EL+ LK+ +E            ++ A+ + ++ E KM+ A+ 
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-----EQIADLQAQIAELKMQLAK- 1087

Query: 786  ERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNE 845
             +E EL+ A  +LD    + + + KK++E +  +  +  +L+  +      ++Q   + E
Sbjct: 1088 -KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 846  AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNND 905
             +++ ++++E      A  +E   K ++EVT  K+ +  +    +A+  E+ +   Q   
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ--- 1203

Query: 906  SQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEA 965
                ++EL   + + KR   +       + K+   +  E  + GQ     + K    +  
Sbjct: 1204 ---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260

Query: 966  GQRLQKLQEMKEKLGRNVNMRAMNVLTEAE-------ERYNDLMKKKRIVENDKSKILTT 1018
             Q LQ      E+    +N +   +  E E       E     +K  + V +  S++  T
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320

Query: 1019 IEDLDQKKNQALNIA 1033
             E L ++  Q LN++
Sbjct: 1321 QELLQEETRQKLNVS 1335



 Score = 34.7 bits (78), Expect = 0.56
 Identities = 26/111 (23%), Positives = 50/111 (45%), Gaps = 19/111 (17%)

Query: 177  KKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIA 236
            +K AA K++++K+ KLKEI   +E+E     Q  ++        +++ R++E        
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE-------- 1887

Query: 237  YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKR 287
                        + EE + +     KLQ EL E  +  +A+  E+  L+ +
Sbjct: 1888 -----------EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  107 bits (267), Expect = 7e-23
 Identities = 183/952 (19%), Positives = 385/952 (40%), Gaps = 119/952 (12%)

Query: 149  RITKVLNMKPPEILSMIEEAAG-----TRMYEYKKI---AAQKTI------EKKEAKLKE 194
            ++ K  +    ++ ++ EE AG      ++ + KK    A Q+T+      E K   L +
Sbjct: 967  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTK 1026

Query: 195  IKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AEDTKVRSAEEL 253
             KT LE+++      L++E+   ++ ++  R++E    L +A +  +  E+ K +  E+L
Sbjct: 1027 AKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLE--GDLKLAQESTMDTENDKQQLNEKL 1084

Query: 254  KEMQDKVIKLQEELSEND-------KKIKALNHEIEELEK----------RKDKETGGIL 296
            K+ + ++  LQ ++ +         KKIK L   IEELE+          + +K+   + 
Sbjct: 1085 KKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKE----V 352
            R LE+     +     + +  ++ KK  A  +  R++LE++ ++   T AA  K+    V
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSV 1204

Query: 353  KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKA 412
             ++ + + +LQ    K  +  +  +   N +++ + +    A+A         ++ +S+ 
Sbjct: 1205 AELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSK-AKANFEKMCRTLEDQLSEI 1263

Query: 413  QTEAKQAQMKLKHAQ--------------QELKNKQAEVKKMDSGYRKDQEALEAVKRLK 458
            +T+ ++ Q  +                  ++L  K A V ++  G +   + +E +KR  
Sbjct: 1264 KTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL 1323

Query: 459  EKLEAEMKKLNYEENKEESLLEKRRQLSR-DIGRLKETYEALLARFPNLRFAYKDPEKN- 516
            E           EE K +S L    Q +R D   L+E YE        L+          
Sbjct: 1324 E-----------EETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEV 1372

Query: 517  --WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYT 574
              W        +     +++     A  L   E     V     + +K  +R + +    
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDL 1432

Query: 575  IIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMD 634
            +I + + +A CIA   L   Q               E + EL+ + +     +     + 
Sbjct: 1433 MIDVERSNAACIA---LDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVK 1489

Query: 635  NAKKVAFD--KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKE 692
            NA + + D  + +      L  ++ D    ++ G +           EL+ V+ +L  ++
Sbjct: 1490 NAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKH--------IHELEKVKKQLDHEK 1541

Query: 693  NELR-ALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKT 751
            +EL+ +LEE  A L++   K  +++ +      E D            ++ EELD LK+ 
Sbjct: 1542 SELQTSLEEAEASLEHEEGKILRIQLELNQVKSEID--------RKIAEKDEELDQLKRN 1593

Query: 752  IEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKK 811
                 E++++T + + ++      ++ KM       E +L + + +L+ A  +A  + + 
Sbjct: 1594 HLRVVESMQSTLDAEIRSRNDALRIKKKM-------EGDLNEMEIQLNHANRQAAEALRN 1646

Query: 812  MKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKA 871
            ++  Q  ++   L L++  R     K+QL  V       ++++E + A + + +     A
Sbjct: 1647 LRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMA 1706

Query: 872  QEEVTKQKEVI----TAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDG 927
            ++E+    E +    T   ++I  K        +   + +  ++E  +   K K+   D 
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDA 1766

Query: 928  AAKVSKMLKDYDW-INAERHLFGQPNSAYDFKTNNP-------KEAGQRLQKLQEMKEKL 979
            A    ++ K+ D   + ER       +  D +           K   +++QKL+    +L
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1826

Query: 980  GRNV------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQK 1025
               V      N+ A+  L + E R  +L  +    E D+  IL  ++DL  K
Sbjct: 1827 ESEVESEQKHNVEAVKGLRKHERRVKELTYQ---TEEDRKNIL-RLQDLVDK 1874



 Score =  106 bits (264), Expect = 2e-22
 Identities = 193/856 (22%), Positives = 355/856 (41%), Gaps = 114/856 (13%)

Query: 154  LNMKPPEILSMIEEAAGTRMYEYKKIA-AQKTIEKKEAKLKEIKTILEEEITPTIQKLKE 212
            L  K  E+ + IEE       E    A A+K       +L+EI   LEE    T  +++ 
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1167

Query: 213  ERSSYLEYQKVMREIEHLSRLYIAYQFLLAE---DTKVRSAEELKEMQDKVIKLQEELSE 269
             +    E+QK+ R++E  +  + A    L +   D+     E++  +Q    KL++E SE
Sbjct: 1168 NKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSE 1227

Query: 270  NDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEES 329
               +I  L   +E + K K      + R+LED L+E   + TK +     +++ L  E S
Sbjct: 1228 LKMEINDLASNMETVSKAK-ANFEKMCRTLEDQLSE---IKTKEE-----EQQRLINELS 1278

Query: 330  KRK-ELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLS 388
             +K  L     E S+ L  K+  V +++ G  A  +   +    L               
Sbjct: 1279 AQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL--------------- 1323

Query: 389  SNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQ 448
              E  A++TLA  + + ++D    + + ++ Q      Q+ +    +EV +  + Y  D 
Sbjct: 1324 EEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETD- 1382

Query: 449  EALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRF 508
             A++  + L+E  +   ++L   E   E++  K   L +   RL+   E L+        
Sbjct: 1383 -AIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA 1441

Query: 509  AYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGE 568
            A    +K   RN  K L       ++T A    EL A ++  +  + TE+   K      
Sbjct: 1442 ACIALDKK-QRNFDKVLAEWKQKYEETQA----ELEASQK-ESRSLSTELFKVKNAYEES 1495

Query: 569  LKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVH----VALSLVEYKPELQKAMEFVF 624
            L    T+   NK   + I+  T ++A+   G  ++H    V   L   K ELQ ++E   
Sbjct: 1496 LDHLETLKRENKNLQQEISDLTEQIAE---GGKHIHELEKVKKQLDHEKSELQTSLEEAE 1552

Query: 625  -------GTTFVCDNMDNAKKVAFDKRIMTRTVTLGG-------DVFDPHGTLSGGARSQ 670
                   G         N  K   D++I  +   L          V     TL    RS+
Sbjct: 1553 ASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSR 1612

Query: 671  AASILTKFQELKDVQDELRIKENEL-RALEEELAGLKNTAEKYRQ--------------L 715
              ++  K ++++   +E+ I+ N   R   E L  L+NT    +               L
Sbjct: 1613 NDALRIK-KKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDL 1671

Query: 716  KQQWEMKTEEADLLQTKLQQ--SSYHK--------QQEELDALKKT--IEESEETLKNTK 763
            K+Q  M    A+L+Q ++++  +S  +        +QE LDA ++   +     +L NTK
Sbjct: 1672 KEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTK 1731

Query: 764  EIQRKAEEKYEVLENKM-------KNAEAERERELKDAQKKLDCAKTKADASS---KKMK 813
               +K E     ++ +M       +NAE + ++ + DA    +  K + D S+   +  K
Sbjct: 1732 ---KKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788

Query: 814  EKQQEVEAITLELEELKR-EHTSYKQQLEAVNEAIKSYESQIEVMA---AEVAKNKESVN 869
              +Q V+ + L L+E ++      K+Q++ +   ++  ES++E       E  K      
Sbjct: 1789 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHE 1848

Query: 870  KAQEEVTKQ-----KEVITAQDTV------IKAKYAEVAKHKEQNNDSQLKIKELDHNIS 918
            +  +E+T Q     K ++  QD V      +KA   +  + +EQ+N +  K ++L H + 
Sbjct: 1849 RRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELE 1908

Query: 919  KHKREAEDGAAKVSKM 934
            + K  A+   ++V+K+
Sbjct: 1909 EAKERADIAESQVNKL 1924



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 183/916 (19%), Positives = 358/916 (39%), Gaps = 168/916 (18%)

Query: 174  YEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRL 233
            ++ K +      EK+ A +KE     +EE+  T  K KE     LE +K++  ++  + L
Sbjct: 838  FKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKE-----LE-EKMVTLMQEKNDL 891

Query: 234  YIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETG 293
             +  Q   AE   +  AEE     D++IK + +L   + KIK +    E+ E+  + E  
Sbjct: 892  QLQVQ---AEADALADAEE---RCDQLIKTKIQL---EAKIKEVTERAED-EEEINAELT 941

Query: 294  GILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK 353
               R LED  +E ++     +      +K     E+K K L + M    +T+A   KE K
Sbjct: 942  AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1001

Query: 354  KITDGLHALQEASNKDAEALAAAQQHFNAVSAG---LSSNEDGAEATLAGQMMAC----- 405
                   ALQEA  +  + L   +   N ++     L    D  E +L  +   C     
Sbjct: 1002 -------ALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLER 1054

Query: 406  -----KNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQE-ALEAVKRLKE 459
                 + D+  AQ      +   +   ++LK K+ E+  +      +Q  A++  K++KE
Sbjct: 1055 AKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKE 1114

Query: 460  KLEAEMKKLNYEENKEESLLEKRRQLSRDIGR-LKETYEALLARFPNLRFAYKDPEKNWN 518
             L+A +++L  E   E +   K  +   D+ R L+E  E L                   
Sbjct: 1115 -LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL------------------- 1154

Query: 519  RNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRRYTI 575
                          ++    T+ ++   ++        E   +K+   LE   L+   T 
Sbjct: 1155 --------------EEAGGATSAQIEMNKK-------REAEFQKMRRDLEESTLQHEATA 1193

Query: 576  IPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDN 635
              L K  A  +A    ++            +L  V+ K E +K+ E       +  NM+ 
Sbjct: 1194 AALRKKHADSVAELGEQID-----------SLQRVKQKLEKEKS-ELKMEINDLASNMET 1241

Query: 636  AKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENEL 695
              K   +   M RT+                   Q + I TK +E + + +EL  ++  L
Sbjct: 1242 VSKAKANFEKMCRTL-----------------EDQLSEIKTKEEEQQRLINELSAQKARL 1284

Query: 696  --------RALEEELA-------GLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHK 740
                    R L+E+ A       G +   ++  +LK+Q E +T+    L   LQ + +  
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARH-- 1342

Query: 741  QQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDC 800
               + D L++  EE +E     +    KA  +      K +    +R  EL++A+KKL  
Sbjct: 1343 ---DCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL-- 1397

Query: 801  AKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLE----------AVNEAIKSY 850
                    ++++++ ++ VEA+  +   L++     + ++E          A   A+   
Sbjct: 1398 --------AQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKK 1449

Query: 851  ESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKH----KEQNNDS 906
            +   + + AE  +  E      E   K+   ++ +   +K  Y E   H    K +N + 
Sbjct: 1450 QRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNL 1509

Query: 907  QLKIKELD----------HNISKHKREAEDGAAKVSKMLKDYD--WINAERHLFGQPNSA 954
            Q +I +L           H + K K++ +   +++   L++ +    + E  +       
Sbjct: 1510 QQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLEL 1569

Query: 955  YDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSK 1014
               K+   ++  ++ ++L ++K    R V      +  E   R ND ++ K+ +E D ++
Sbjct: 1570 NQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSR-NDALRIKKKMEGDLNE 1628

Query: 1015 ILTTIEDLDQKKNQAL 1030
            +   +   +++  +AL
Sbjct: 1629 MEIQLNHANRQAAEAL 1644



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 157/754 (20%), Positives = 320/754 (42%), Gaps = 104/754 (13%)

Query: 184  TIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE-HLSRLYIA---YQF 239
            ++++ + KL++ K+ L+ EI      ++    +   ++K+ R +E  LS +       Q 
Sbjct: 1213 SLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQR 1272

Query: 240  LLAEDT--KVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILR 297
            L+ E +  K R   E  E   ++ +    +S+  +  +A   +IEEL+++ ++ET     
Sbjct: 1273 LINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEET----- 1327

Query: 298  SLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITD 357
              +  LA A +    ++   DL ++    E+  + EL++ M + +  +A  +   K  TD
Sbjct: 1328 KAKSTLAHALQ---SARHDCDLLREQYEEEQEAKAELQRGMSKANSEVA--QWRTKYETD 1382

Query: 358  GLHA---LQEASNKDAEALAAAQQHFNAVS---AGLSSNEDGAEATLAGQMM-------A 404
             +     L+EA  K A+ L  A++H  AV+   A L   +   +  +   M+       A
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAA 1442

Query: 405  C------KNDISKAQTEAKQ----AQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV 454
            C      + +  K   E KQ     Q +L+ +Q+E ++   E+ K+ + Y +  + LE +
Sbjct: 1443 CIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETL 1502

Query: 455  KRLKEKLEAEMKKLNY---EENKEESLLEK-RRQLSRDIGRLKETYEALLARFPNLRFAY 510
            KR  + L+ E+  L     E  K    LEK ++QL  +   L+ + E   A   +     
Sbjct: 1503 KRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKI 1562

Query: 511  KDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNV-----VVDTEVTGKKLLE 565
               +   N+  VK  +   I+ KD      L+ +    L  V      +D E+  +    
Sbjct: 1563 LRIQLELNQ--VKSEIDRKIAEKDEE----LDQLKRNHLRVVESMQSTLDAEIRSRNDAL 1616

Query: 566  RGELKRRYTI----IPLNKISARCIAPETLRVAQN---------------LVGPDNVHVA 606
            R + K    +    I LN  + +  A E LR  +N               + G D++   
Sbjct: 1617 RIKKKMEGDLNEMEIQLNHANRQ--AAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQ 1674

Query: 607  LSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGG 666
            L++VE +  L +A       +   +  +  +K+A ++ ++  +  +   +     T    
Sbjct: 1675 LAMVERRANLMQAEVEELRASL--ERTERGRKMA-EQELLDASERV--QLLHTQNTSLIN 1729

Query: 667  ARSQAASILTKFQ-ELKDVQDELRIKENELRA-------LEEELAGLKNTAEKYRQLKQQ 718
             + +  + +++ Q E++D+  E R  E + +        + EEL   ++T+    ++K+ 
Sbjct: 1730 TKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789

Query: 719  WE-------MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE----ETLKNTKEIQR 767
             E       ++ +EA+ L  K  +    K +  +  L+  +E  +    E +K  ++ +R
Sbjct: 1790 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHER 1849

Query: 768  KAEEKYEVLENKMKNAEAERERELKD-AQKKLDCAKTKADASSKKMKEKQQEVEAITLEL 826
            + +E     E   KN    R ++L D  Q K+   K +A+ + ++      +   +  EL
Sbjct: 1850 RVKELTYQTEEDRKN--ILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHEL 1907

Query: 827  EELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860
            EE K      + Q+  +   +KS E   +V++ E
Sbjct: 1908 EEAKERADIAESQVNKLR--VKSREVHTKVISEE 1939


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
          Length = 1116

 Score =  106 bits (264), Expect = 2e-22
 Identities = 181/784 (23%), Positives = 336/784 (42%), Gaps = 88/784 (11%)

Query: 182  QKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL 241
            +KT+E+ E +++  K  L        + L+  +S  L  +    + E   RL  A   + 
Sbjct: 285  RKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVH 344

Query: 242  AEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLED 301
              ++ +   E+   M  + +  + E + +  K KAL   IE     KD +   + R L D
Sbjct: 345  HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIE----MKDSKISSMERGLRD 400

Query: 302  ALAEAQRVNTKSQSAFDLKKKNLACEESKRKELE-------KNMVEDSKT-LAAKE---K 350
               E Q +  KS  A   +++    EE K+ E+        KN VE  K  L++KE   +
Sbjct: 401  LEEEIQML--KSNGALSTEERE---EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWE 455

Query: 351  EVKKITDGLHA-----LQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMAC 405
            E+KK   GL A      QE S KD E LA  Q     ++   S ++   E  L   + A 
Sbjct: 456  ELKKKAAGLQAEIGQVKQELSRKDTELLAL-QTKLETLTNQFSDSKQHIEV-LKESLTAK 513

Query: 406  KNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEM 465
            +   +  QTE    +++L+  +  L  K  +++  D    K  +A E +  LK+ L+ + 
Sbjct: 514  EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ--DMAEEKGTQAGE-IHDLKDMLDVKE 570

Query: 466  KKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGL 525
            +K+N  + K E+L E+ R   + +  LKE  ++L A   N   A    E+       +  
Sbjct: 571  RKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEK--ERT 628

Query: 526  VASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL-LERGELKRRYTIIPLNKISAR 584
            +  L   +D       E    E + N   D +   +K+ L +G+L  +   +   K  A 
Sbjct: 629  IERLKEQRDRD-----EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHAS 683

Query: 585  CIAPETLRVAQNLVGPDNVHVAL-----SLVEYKPELQKAMEFVFGTTFVCDNMDNAKKV 639
             +A   L+    L     + +AL       ++ + +L+KA E         +  D  + +
Sbjct: 684  SLASSGLKKDSRL---KTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHL 740

Query: 640  AFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALE 699
               +R +TR           +   S  A+++   +L   + LK+V++E   K+ ++  LE
Sbjct: 741  ---EREITR-----------YKDESSKAQAEVDRLL---EILKEVENEKNDKDKKIAELE 783

Query: 700  EELAGLKNTAEKYRQL--KQQWEMKTEEADLLQTKLQQSSYHKQQEEL-DALKK---TIE 753
             +   +K+  +K   L  K+Q E K     L + + ++ + +   ++L D+L+K    IE
Sbjct: 784  RQ---VKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 840

Query: 754  ESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQK---KLDCAKTKADASSK 810
            E EE L+ + +I  + E      E+   NAE + E  L   +K   +L+  K K  ++ +
Sbjct: 841  ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 900

Query: 811  KMKEKQQEVEAITLELEELKREHTSYKQQ--LEAVNE--------AIKSYESQIEVMAAE 860
             + EK+  +  +  E  +   E    KQ+  L A++E         + S + + +   A 
Sbjct: 901  SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 960

Query: 861  VAKNKESVNKAQEEVTKQKEVITA---QDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNI 917
            + + K+ + +  ++ T+ +  + A   +D   K+ ++    HK   +     + ELD N 
Sbjct: 961  LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 1020

Query: 918  SKHK 921
            SK K
Sbjct: 1021 SKLK 1024



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 191/890 (21%), Positives = 371/890 (41%), Gaps = 167/890 (18%)

Query: 182  QKTIEKKEAKLKEIKTILEEEITPTIQK---LKEERSSYL-----EYQKVMREIEHLSRL 233
            +K +E KE+KL      ++   +P ++K   L+++ +S +     +Y+ V  E +H+   
Sbjct: 169  RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMT 228

Query: 234  YIAYQF----------LLAEDTKVRSAE----ELKEMQDKVIKLQEELSENDKKIKALNH 279
              A Q           L  +D+  R+ E    EL E  +   +L  E     K++  L  
Sbjct: 229  IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE--ENFQRLHAEHERQAKELFLLRK 286

Query: 280  EIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKR-KELEKNM 338
             +EE+E R + +   +    E      + + +K  SA   ++ +   E ++R  E E ++
Sbjct: 287  TLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDH---ERTRRLAEAEMHV 343

Query: 339  VEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATL 398
                  L  KEKE   + + +H   E +  D+    A Q       + +SS E G    L
Sbjct: 344  HHLESLLEQKEKENSMLREEMHRRFENA-PDSAKTKALQTVIEMKDSKISSMERGLR-DL 401

Query: 399  AGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLK 458
              ++   K++     TE ++ +MK           Q EV +  S + K++     V++LK
Sbjct: 402  EEEIQMLKSN-GALSTEEREEEMK-----------QMEVYRSHSKFMKNK-----VEQLK 444

Query: 459  EKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWN 518
            E+L ++  +    + K   L  +  Q+ +++ R      AL  +   L   + D +++  
Sbjct: 445  EELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH-- 502

Query: 519  RNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPL 578
               ++ L  SL + +  +A               ++ TEV   +L     L+ + T++  
Sbjct: 503  ---IEVLKESLTAKEQRAA---------------ILQTEVDALRL----RLEEKETMLNK 540

Query: 579  NKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKK 638
                 + +A E    A        +H    +++ K      ++           ++N ++
Sbjct: 541  KTKQIQDMAEEKGTQA------GEIHDLKDMLDVKERKVNVLQ---------KKIENLQE 585

Query: 639  VAFDKR-----IMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQD-ELRIKE 692
               DK      +  R  +L  D  +    L+    + A    T  + LK+ +D + R K+
Sbjct: 586  QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT-IERLKEQRDRDEREKQ 644

Query: 693  NELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTI 752
             E+   +++L  LK   EK   L  Q ++  +EA LL  K   SS      + D+  KT+
Sbjct: 645  EEIDNYKKDLKDLK---EKVSLL--QGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 699

Query: 753  EESEETLKNTKEIQRKAEEKYEVLENKMKNA-----EAERERELKDAQKKLDCAKTK-AD 806
            E +         +++K EE  + +E+++K A     EA    E+ D  + L+   T+  D
Sbjct: 700  EIA---------LEQKKEECLK-MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD 749

Query: 807  ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKE 866
             SSK     Q EV+ +   L+E++ E     +++  +   +K              +NK+
Sbjct: 750  ESSK----AQAEVDRLLEILKEVENEKNDKDKKIAELERQVKD-------------QNKK 792

Query: 867  SVN-KAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQN-NDSQLKIKELDHNISKHKREA 924
              N K +E+V K+K           A+  E A+ +E N NDS  ++++         R+ 
Sbjct: 793  VANLKHKEQVEKKK----------SAQMLEEARRREDNLNDSSQQLQD-------SLRKK 835

Query: 925  EDGAAKVSKMLKDYDWINAERHL-FGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV 983
            +D   ++ + L++   I AER +   Q  SA   +TN  K+  + L  ++++K++L    
Sbjct: 836  DDRIEELEEALRESVQITAEREMVLAQEESA---RTNAEKQVEELLMAMEKVKQEL---E 889

Query: 984  NMRA-----MNVLTEAEERYNDLMKKKR-----IVENDKSKILTTIEDLD 1023
            +M+A        L E E    +L  ++R     ++E  +  +L  I + D
Sbjct: 890  SMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKD 939



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 85/409 (20%), Positives = 185/409 (45%), Gaps = 71/409 (17%)

Query: 680  ELKDVQDELRIKENELRALEEELAGLKNTAEKYRQ----LKQQWEMKTEEADLLQTKLQQ 735
            E+  V+ EL  K+ EL AL+ +L  L N     +Q    LK+    K + A +LQT    
Sbjct: 467  EIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQT---- 522

Query: 736  SSYHKQQEELDALKKTIEESEETL-KNTKEIQRKAEEKYEVLE--NKMKNAEAERERELK 792
                    E+DAL+  +EE E  L K TK+IQ  AEEK       + +K+    +ER++ 
Sbjct: 523  --------EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 574

Query: 793  DAQKKLDCAKTKADASSKKMKEKQQEVEAI------------TLE---------LEELK- 830
              QKK++  + +     K+M   ++ V+++            TLE         +E LK 
Sbjct: 575  VLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKE 634

Query: 831  ---REHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDT 887
               R+    +++++   + +K  + ++ ++  ++++ + S+   +E  +        +D+
Sbjct: 635  QRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694

Query: 888  VIKAKYAEVAKHKEQ--NNDSQLK------------------IKELDHNISKHKREAEDG 927
             +K     + + KE+    +SQLK                  I+ L+  I+++K E+   
Sbjct: 695  RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 754

Query: 928  AAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRA 987
             A+V ++L+    +  E++   +  +  + +  +  +    L+  +++++K       ++
Sbjct: 755  QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKK-------KS 807

Query: 988  MNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQK 1036
              +L EA  R ++L    + +++   K    IE+L++   +++ I  ++
Sbjct: 808  AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER 856



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 84/441 (19%), Positives = 195/441 (44%), Gaps = 71/441 (16%)

Query: 668  RSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEAD 727
            + +A+ I    ++ + VQ+E +  +  ++AL++EL   ++  + ++Q       +   A+
Sbjct: 202  KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAE 261

Query: 728  LLQTKLQQ--SSYHKQQEELDALKKTIEESE---ETLKNTKEIQRKAEEK-YEVLENKMK 781
            L +   Q+  + + +Q +EL  L+KT+EE E   ET K T   + ++ +K  E+L++K  
Sbjct: 262  LTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 321

Query: 782  NAEA-----ERERELKDAQKKL-----------------------------DCAKTKA-- 805
            +A+A     ER R L +A+  +                             D AKTKA  
Sbjct: 322  SAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQ 381

Query: 806  ----------DASSKKMKEKQQEVEAI-------TLELEELKREHTSYKQQLEAVNEAIK 848
                       +  + +++ ++E++ +       T E EE  ++   Y+   + +   ++
Sbjct: 382  TVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVE 441

Query: 849  SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQL 908
              + ++    A+  + K+     Q E+ + K+ ++ +DT + A   ++     Q +DS+ 
Sbjct: 442  QLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 501

Query: 909  KIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQR 968
             I+ L  +++  ++ A     +V  +    +    E  L  +     D       +AG+ 
Sbjct: 502  HIEVLKESLTAKEQRAAILQTEVDALRLRLE--EKETMLNKKTKQIQDMAEEKGTQAGE- 558

Query: 969  LQKLQEMKEKLGRNVNMRAMNV------LTEAEERYNDLMKKKRIVENDKSK---ILTTI 1019
            +  L++M +   R VN+    +      L + E++ + L ++ + ++ D +     LTT+
Sbjct: 559  IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 618

Query: 1020 EDLDQKKNQALNIAWQKVNKD 1040
            E+   +K + +    ++ ++D
Sbjct: 619  EEALAEKERTIERLKEQRDRD 639



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 83/409 (20%), Positives = 162/409 (39%), Gaps = 54/409 (13%)

Query: 120 VNANNTRVQDLFCSVGLNVNNPH----FLIMQGRITKVLNMKPPEILSMIEEAAGTRMYE 175
           +N    ++QD+    G      H     L ++ R   VL  K   +   + +        
Sbjct: 538 LNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSL 597

Query: 176 YKKIAAQKTIEKKEAKLKEIKTILEEEITP---TIQKLKEERSSYLEYQKVMREIEHLSR 232
            +++   K+++          T LEE +     TI++LKE+R    + ++   EI++  +
Sbjct: 598 KERV---KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR--DEREKQEEIDNYKK 652

Query: 233 LYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEK---RKD 289
                              +LK++++KV  LQ +LSE +  +  L      L     +KD
Sbjct: 653 -------------------DLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 693

Query: 290 KETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKE 349
                 L++LE AL + +    K +S   LKK + A  E++         E S  +   E
Sbjct: 694 SR----LKTLEIALEQKKEECLKMES--QLKKAHEAALEARASP------EMSDRIQHLE 741

Query: 350 KEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDI 409
           +E+ +  D     Q   ++  E L   +   N     ++      E  +  Q     N  
Sbjct: 742 REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAE----LERQVKDQNKKVANLK 797

Query: 410 SKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQ---EALEAVKRLKEKLEAEMK 466
            K Q E K++   L+ A++   N     +++    RK     E LE   R   ++ AE +
Sbjct: 798 HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAERE 857

Query: 467 KLNYEENKEESLLEKR-RQLSRDIGRLKETYEALLARFPNLRFAYKDPE 514
            +  +E    +  EK+  +L   + ++K+  E++ A+  + + +  + E
Sbjct: 858 MVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKE 906



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 69/358 (19%), Positives = 157/358 (43%), Gaps = 38/358 (10%)

Query: 680  ELKDVQDELRIKENELRALEEELAGLKNTAEKY--RQLKQQWEMKTEEADLLQTKLQQSS 737
            +LK+V  E  +   ++   E +L+   N+ + +   +LK++  ++ +EA  +    +Q  
Sbjct: 157  QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQ-- 214

Query: 738  YHKQQEELDALKKTIEESEETLKNTKEIQRKAEEK----------YEVLENKMKNAEAER 787
            Y   QEE   ++ TI+  ++ L+  +++ +  ++            E+ E   +   AE 
Sbjct: 215  YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEH 274

Query: 788  ERE----------LKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
            ER+          L++ + +++  K   +A  + +K+  + +++  L  +  + +H   +
Sbjct: 275  ERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTR 334

Query: 838  QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVA 897
            +  EA    +   ES +E    E +  +E +++  E      +   A  TVI+ K ++++
Sbjct: 335  RLAEA-EMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKT-KALQTVIEMKDSKIS 392

Query: 898  KHKEQNNDSQLKIKELDHN--ISKHKREAEDGAAKV----SKMLKDYDWINAERHLFGQP 951
              +    D + +I+ L  N  +S  +RE E    +V    SK +K     N    L  + 
Sbjct: 393  SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMK-----NKVEQLKEEL 447

Query: 952  NSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVE 1009
            +S         K+A     ++ ++K++L R  +   + + T+ E   N     K+ +E
Sbjct: 448  SSKEAQWEELKKKAAGLQAEIGQVKQELSRK-DTELLALQTKLETLTNQFSDSKQHIE 504


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  106 bits (264), Expect = 2e-22
 Identities = 186/895 (20%), Positives = 367/895 (41%), Gaps = 135/895 (15%)

Query: 166  EEAAGTRMYEYKKIAAQKTIEKKE----------AKLKEIKTILEEEITPTIQKLKEERS 215
            EE    +  + +K+ A+  I+K E          +K  + K ++E+ I     +L EE  
Sbjct: 961  EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020

Query: 216  SYLEYQKVMREIE--------HLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEEL 267
                  K+  + E         L +     Q L  E  K +   E  ++QD++ +LQ ++
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL--EKAKRKLDGETTDLQDQIAELQAQI 1078

Query: 268  SENDKKIKALNHEIEELEKRKDKETGG------ILRSLEDALAEAQRVNTKSQSAFDLKK 321
             E   ++     E++    R D ET        ++R L+  +AE Q  + +S+ A   K 
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE-DFESEKASRNKA 1137

Query: 322  KNLACEESKRKELEKNMVEDSKTLAAKEKEVK-----KITDGLHALQEAS-NKDAEALAA 375
            +    + S+  E  K  +ED+    A ++E++     ++ +   AL+E + N +A+    
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197

Query: 376  AQQHFNAVS-------------AGLSSNEDGAEATLAGQMMACKNDI-SKAQTEAKQAQM 421
             Q+H  A+              A L  N+ G E     + +AC+  +  + + E++  + 
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETD--NKELACEVKVLQQVKAESEHKRK 1255

Query: 422  KLKHAQQELKNKQAEVKKMD----SGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEES 477
            KL    QEL  K +E  ++         K Q  L+ V  L E+ E +  K   +    ES
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315

Query: 478  LLEKRRQLSRDIGRLKETYEALLARFP---NLRFAYKDPEKNWNRNCVKGLVASLISVKD 534
             L+  ++L ++  R K    + + +     N     ++ E+   +N  K ++A    + D
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLAD 1375

Query: 535  TSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVA 594
            T      +L   E L       E   KKLL+  E   +       ++  + +A + L   
Sbjct: 1376 TKKKVDDDLGTIESL-------EEAKKKLLKDAEALSQ-------RLEEKALAYDKLEKT 1421

Query: 595  QNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGG 654
            +N +  +   + + L   +               V  N++  +K  FD+ ++    ++  
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQ--------------VASNLEKKQK-KFDQ-LLAEEKSISA 1465

Query: 655  DVFDPHGTLSGGAR---SQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEK 711
               +        AR   ++A S+    +E  + ++E   +  +LRA  E+L   K+   K
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525

Query: 712  Y--------RQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELD--ALKKTIEESEETLKN 761
                     R L+QQ E    + + L+ +LQ +   K + E++  A+K   E   +T   
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR-- 1583

Query: 762  TKEIQRKAEEKYEVLENKMKNAEAERERE-----------------LKDAQKKLDCAKTK 804
                  + EEK  +L  +++  EAE E E                 LKD + +++ A   
Sbjct: 1584 ----DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639

Query: 805  ADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
             D   K++++ Q +++    ELEE +        Q +   + +KS E++I  +  E+A +
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699

Query: 865  KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREA 924
            + +   A++E  +  + IT   +   A         ++    + +I +L+  + + +   
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALL-------DEKRRLEARIAQLEEELEEEQSNM 1752

Query: 925  EDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKL 979
            E    +  K     D +NAE  L  + ++A   K++N ++  +R  K  E+K KL
Sbjct: 1753 ELLNDRFRKTTLQVDTLNAE--LAAERSAAQ--KSDNARQQLERQNK--ELKAKL 1801



 Score =  101 bits (251), Expect = 5e-21
 Identities = 158/784 (20%), Positives = 327/784 (41%), Gaps = 95/784 (12%)

Query: 180  AAQKTIEKKEAKLKEIKTILEEEIT---PTIQKLKEERSSYLEYQKVMREIEHLSRLY-- 234
            A Q+   K+E ++ E+K  LEEE       IQ +++  ++ LE  ++  ++E   R    
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALE--ELSEQLEQAKRFKAN 1221

Query: 235  --------------IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDK-------K 273
                          +A +  + +  K  S  + K++  +V +L  ++SE D+       K
Sbjct: 1222 LEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK 1281

Query: 274  IKALNHEIEELEKR-KDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKK-NLAC----- 326
               L +E++ +    ++ E  GI  + + A  E+Q  +T+     + ++K NL+      
Sbjct: 1282 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341

Query: 327  -------------EESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNK---DA 370
                         EE  RK LEK ++     LA  +K+V      + +L+EA  K   DA
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401

Query: 371  EALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQEL 430
            EAL+   +        L   ++  +  L        +D++      +Q    L+  Q++ 
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQEL--------DDLTVDLDHQRQVASNLEKKQKKF 1453

Query: 431  KNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIG 490
                AE K + + Y ++++  EA  R     E E K L+     EE+L E + +  R   
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAR-----EKETKALSLARALEEAL-EAKEEFERQNK 1507

Query: 491  RLKETYEALLARFPNLRFAYKDPEKNWN--RNCVKGLVASLISVKDT-SATTALELVAGE 547
            +L+   E L++   ++     + EK+       V+ +   L  ++D   AT   +L    
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567

Query: 548  RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
             +  +    E   +   E+ E K+R  I  + ++ A     E  R  + L       + +
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL---EDERKQRALAVASKKKMEI 1624

Query: 608  SLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD-KRIMTRTVTLGGDVFDPHGTLSGG 666
             L + + +++ A +       V   +   +    D +R +        ++F         
Sbjct: 1625 DLKDLEAQIEAANK---ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681

Query: 667  ARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTA-----EKYR------QL 715
             +S  A IL   +EL   +   R  E E   L +E+    +       EK R      QL
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741

Query: 716  KQQWEMKTEEADLLQTKLQQSSYH------KQQEELDALKKTIEESEETLKNTKEIQRKA 769
            +++ E +    +LL  + ++++        +   E  A +K+    ++  +  KE++ K 
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL 1801

Query: 770  EEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEEL 829
            +E    +++K K   +  E ++   +++L+    +  A++K ++  +++++ I +++E+ 
Sbjct: 1802 QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDE 1861

Query: 830  KREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEV---TKQKEVITAQD 886
            +R    YK+Q+E  N  +K  + Q+E    E  +   S  K Q E+   T+  E ++ + 
Sbjct: 1862 RRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREV 1921

Query: 887  TVIK 890
            + +K
Sbjct: 1922 STLK 1925



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 184/901 (20%), Positives = 374/901 (41%), Gaps = 161/901 (17%)

Query: 214  RSSYLEYQKVMREIEHLSRLYIAYQFLLAED-----TKVRSAEELKEMQDKVIKLQEELS 268
            R ++ + Q+ +  ++ L R   AY  L         TKV+   ++   ++++    EEL 
Sbjct: 803  RKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELL 862

Query: 269  ENDKKIKALNHEIEELEKR----------------------------------KDKETGG 294
            +  +K   +  E+EE+E++                                  K +E   
Sbjct: 863  KVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEE 922

Query: 295  ILRSLEDALAEAQRVN-------TKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAA 347
            IL  LE  + E +  N        K Q+     ++ L  EE  R++L+   V        
Sbjct: 923  ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV-------T 975

Query: 348  KEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE--ATLAGQMMAC 405
             E ++KK+ + +  L++ ++K  +     +      S+ L+  E+ A+  A +  +    
Sbjct: 976  AEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM 1035

Query: 406  KNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRK--DQEALEAVKRLKEKLEA 463
             +D+ +   + ++ + +L+ A+++L  +  +++   +  +   D+  L+  K+ +E+L+ 
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK-EEELQG 1094

Query: 464  EMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
             + + + E   + + L+  R+L   I  L+E +E+          A ++  +   R+  +
Sbjct: 1095 ALARGDDETLHKNNALKVVRELQAQIAELQEDFES--------EKASRNKAEKQKRDLSE 1146

Query: 524  GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISA 583
             L A    ++DT  TTA +              E+  K+  E  ELK             
Sbjct: 1147 ELEALKTELEDTLDTTAAQ-------------QELRTKREQEVAELK------------- 1180

Query: 584  RCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTT-----FVCDNMDNAKK 638
            + +  ET      +      H A +L E   +L++A  F             DN + A +
Sbjct: 1181 KALEEETKNHEAQIQDMRQRH-ATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239

Query: 639  VAFDKRIMT----RTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENE 694
            V   +++      +   L   V + H  +S G R +   +  K  +L++  D +     E
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR-VELAEKASKLQNELDNVSTLLEE 1298

Query: 695  LRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQ-QEELDALKKTIE 753
              A ++ +   K+ A    QL+   E+  EE    + KL  SS  +Q +EE ++L++  E
Sbjct: 1299 --AEKKGIKFAKDAASLESQLQDTQELLQEET---RQKLNLSSRIRQLEEEKNSLQEQQE 1353

Query: 754  ESEETLKNTKE-----IQRKAEEKYEVLEN--KMKNAEAERERELKDAQKKLDCAKTKAD 806
            E EE  KN ++       + A+ K +V ++   +++ E  +++ LKDA+      + KA 
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL 1413

Query: 807  ASSKKMKEK---QQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK 863
            A  K  K K   QQE++ +T++L+  +R+  S  ++ +   + + + E  I    AE   
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDH-QRQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472

Query: 864  NKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD------HNI 917
              E+  +A+E+ TK   +  A +  ++AK     ++K+   D +  +   D      H +
Sbjct: 1473 RAEA--EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530

Query: 918  SKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKE 977
             K KR  E    ++   L++ +                             LQ  ++ K 
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELE---------------------------DELQATEDAKL 1563

Query: 978  KLGRNVNMRAMNVLTEAEERYNDLM--KKKRIVENDKSKILTTIEDLDQKKNQALNIAWQ 1035
            +L   VNM+AM    E + +  D    +KKR++     ++   +E  D++K +AL +A +
Sbjct: 1564 RL--EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE--DERKQRALAVASK 1619

Query: 1036 K 1036
            K
Sbjct: 1620 K 1620



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 174/803 (21%), Positives = 327/803 (40%), Gaps = 107/803 (13%)

Query: 183  KTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREI-EHLSRLYIAYQFLL 241
            +T+ K  A LK ++  L+ +I    +  + E++S  + +K  R++ E L  L    +  L
Sbjct: 1102 ETLHKNNA-LKVVRE-LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159

Query: 242  AEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLED 301
              DT     E   + + +V +L++ L E  K     NHE +  + R+   T   L  L +
Sbjct: 1160 --DTTAAQQELRTKREQEVAELKKALEEETK-----NHEAQIQDMRQRHATA--LEELSE 1210

Query: 302  ALAEAQRVNT---KSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK-KITD 357
             L +A+R      K++   +   K LACE    ++++       K L A+ +E+  K+++
Sbjct: 1211 QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSE 1270

Query: 358  GLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGA------EATLAGQMMACKNDISK 411
            G     E     AE  +  Q   + VS  L   E          A+L  Q+   +  + +
Sbjct: 1271 GDRLRVEL----AEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE 1326

Query: 412  AQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYE 471
               +      +++  ++E KN   E ++ +   RK+ E  + V  L+ +L    KK++ +
Sbjct: 1327 ETRQKLNLSSRIRQLEEE-KNSLQEQQEEEEEARKNLE--KQVLALQSQLADTKKKVDDD 1383

Query: 472  ENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLIS 531
                ESL E +++L +D        EAL  R      AY   EK  NR            
Sbjct: 1384 LGTIESLEEAKKKLLKDA-------EALSQRLEEKALAYDKLEKTKNR------------ 1424

Query: 532  VKDTSATTALELVAGERLYNVVVDTEVTGKKL--LERGELKRRYTIIPLNKISARCIAPE 589
                           + L ++ VD +   +    LE+ + K    +     ISAR     
Sbjct: 1425 -------------LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471

Query: 590  TLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRT 649
                A+     +    ALSL     E  +A E             N +  A  + +M+  
Sbjct: 1472 DRAEAE---AREKETKALSLARALEEALEAKEEF--------ERQNKQLRADMEDLMSSK 1520

Query: 650  VTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTA 709
              +G +V +    L    R+    +     +L++++DEL+  E+    LE  +  +K  A
Sbjct: 1521 DDVGKNVHE----LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK--A 1574

Query: 710  EKYRQLKQQWEMKTEEADLLQTKLQQ-----SSYHKQQEELDALKKTIEESEETLKNTKE 764
            +  R L+ + E   E+  LL  ++++         KQ+    A KK +E   + L+   E
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634

Query: 765  IQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITL 824
               KA ++      K++    + +REL++A+   D    ++  S KK+K  + E+  +  
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694

Query: 825  ELEELKREHTSYKQQLEAVNEAIKSYES-----------------QIEVMAAEVAKNKES 867
            EL   +R     +Q+ + + + I +  S                 Q+E    E   N E 
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754

Query: 868  VNKAQEEVTKQKEVITAQDTVIK--AKYAEVAKHK--EQNNDSQLKIKELDHNI-SKHKR 922
            +N    + T Q + + A+    +  A+ ++ A+ +   QN + + K++EL+  + SK K 
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKA 1814

Query: 923  EAEDGAAKVSKMLKDYDWINAER 945
                  AK+ ++ +  +    ER
Sbjct: 1815 TISALEAKIGQLEEQLEQEAKER 1837



 Score = 31.6 bits (70), Expect = 4.7
 Identities = 26/111 (23%), Positives = 49/111 (44%), Gaps = 19/111 (17%)

Query: 177  KKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIA 236
            ++ AA K + + E KLKEI   +E+E     Q  ++   +    +++ R++E        
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE------- 1888

Query: 237  YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKR 287
                 AE+   R+    +       KLQ EL +  +  + L+ E+  L+ R
Sbjct: 1889 -----AEEEATRANASRR-------KLQRELDDATEANEGLSREVSTLKNR 1927


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score =  105 bits (262), Expect = 3e-22
 Identities = 202/935 (21%), Positives = 401/935 (42%), Gaps = 121/935 (12%)

Query: 171  TRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL-----EYQKVMR 225
            T+  + K    ++ +E + A LK+   IL + ++ T  +L+ ++S+ L     +Y +++ 
Sbjct: 401  TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460

Query: 226  EI-EHLSRLYIA-YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEE 283
            E+ E   +L     Q   AE    +   +L+E + +  ++Q  + +   + +A   +++ 
Sbjct: 461  ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520

Query: 284  LEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSK 343
                K+ E   +   L D L   Q++  +     + ++K +  EES + +++ +++E ++
Sbjct: 521  KFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ-DILEQNE 579

Query: 344  TLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMM 403
             L A+ ++           Q A+   A  LA   +  + V A         E +LA +  
Sbjct: 580  ALKAQIQQFHS--------QIAAQTSASVLA---EELHKVIAEKDKQIKQTEDSLASE-- 626

Query: 404  ACKNDISKAQTEAKQAQ---MKLKHAQQELK---NKQA----EVKKMD-SGYRKDQEALE 452
              ++ ++  + E K  Q     LK   Q+L+   N+QA    E++KM  S Y KD +   
Sbjct: 627  --RDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK--- 681

Query: 453  AVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKD 512
             ++ L+E+L+ E+     EE K   L ++ + L  ++ +L    + L++  PN     KD
Sbjct: 682  -IRLLEEQLQHEISN-KMEEFK--ILNDQNKALKSEVQKL----QTLVSEQPN-----KD 728

Query: 513  PEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVV------VDTEVTGKKLLER 566
              +   + C++     L +V++   T  +++   E   N +      +  EV   K  + 
Sbjct: 729  VVEQMEK-CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQN 787

Query: 567  GELKRRYTIIPLNKI----SARCIAPETLRVAQNL-VGPDNVHVALSLVEYKPELQKAME 621
             ++     +  L K+      +  + E L  A+ L V      V LS+     ELQ  ++
Sbjct: 788  DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLK 847

Query: 622  FVFGTTFVCDNMDNAKKVAFDK-RIMTRTVTLGGDVFDPHGTLSGGARSQA------ASI 674
               G     + M+  K V  +K + +  T     D+ + + +L    +  A      AS 
Sbjct: 848  ---GKE---EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS 901

Query: 675  LTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE-----MKTEEADLL 729
             ++F+EL+ V   L+ KENEL+ LE  L   ++      QL Q  +      K++   L 
Sbjct: 902  ASQFEELEIV---LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK 958

Query: 730  QTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERER 789
            Q   QQ+S     EEL    K I E E+ +     +  + +   + +E++ K     RE+
Sbjct: 959  QQNYQQASSFPPHEEL---LKVISEREKEISG---LWNELDSLKDAVEHQRKKNNDLREK 1012

Query: 790  ELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE---------HTSYKQQL 840
              +  +      K   D  +K  KE+QQ+VEA+ LE +E+ ++         + SY + L
Sbjct: 1013 NWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWL 1072

Query: 841  EAVNEAIK------SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVI----K 890
                +  K      S   +++V+  ++ +  E     Q E  K K V+   + ++    +
Sbjct: 1073 HGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR 1132

Query: 891  AKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAER-HLFG 949
            +   E  K K + ++S   IK++  + +  ++E E    ++    KD + +  ER HL  
Sbjct: 1133 SVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE----RLRSENKDIENLRREREHLEM 1188

Query: 950  QPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVE 1009
            +   A   ++    E  +   +L E   KL    N        E ++   DL K ++ +E
Sbjct: 1189 ELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQN--------ERQKVAGDLHKAQQSLE 1240

Query: 1010 NDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSI 1044
              +SKI+    D    +N  ++   +   K+  S+
Sbjct: 1241 LIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1275



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 169/917 (18%), Positives = 357/917 (38%), Gaps = 125/917 (13%)

Query: 179  IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQ 238
            +    ++ +++ K K+ K +LEE++      +KE  +S +  +KV  E   +++      
Sbjct: 105  VETSSSVRERKKKEKKQKPVLEEQV------IKESDASKIPGKKV--EPVPVTKQPTPPS 156

Query: 239  FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKAL--NHEIEELEKRKDKETGGIL 296
               A   K    ++ K   D   K  E L    K+ +AL  + E ++      K+     
Sbjct: 157  EAAASKKKP-GQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKK 215

Query: 297  RSLEDALAEAQRV----------NTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLA 346
            +  E+   +   +          N  S    D ++     +  + + ++K+  +  KT  
Sbjct: 216  QKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTET 275

Query: 347  AKEKEVKKITDGLHALQEASNKDAEALAAA---QQHFNAVSAGLSSNEDGAEATLAGQMM 403
             KE    K  D L +L+     + EAL      ++    +   L  +  G   TL  Q+ 
Sbjct: 276  DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335

Query: 404  ACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEA 463
                 ++  + +A   + + K   QE+  ++             + +   + R+K+++  
Sbjct: 336  EKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-------------ERSNVVITRMKDRIGT 382

Query: 464  EMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
              K+ N  +NK     ++ +Q+     +++E  EA +A         +D   N       
Sbjct: 383  LEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLES 442

Query: 524  GLVASLISVKDTSATTALEL------VAGERLYNVVVDTEVTGKKLLERGELKRRYTIIP 577
               A L  ++   A    EL      +  E +     +   T  K ++  E +RR+  + 
Sbjct: 443  KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLK-VQLQEAERRWEEVQ 501

Query: 578  LNKISARCIAPETLR--VAQNLVGPDN----VHVAL--SLVEYKPELQKAMEFVFGTTFV 629
             + I  R    E  +  +    V  +N    +H  L  +LV  +   Q+ M+ +      
Sbjct: 502  -SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKR 560

Query: 630  CDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAAS------ILTKFQELKD 683
             +  ++ +    D  I+ +   L   +   H  ++    +   +      I  K +++K 
Sbjct: 561  VNKEESLQMQVQD--ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ 618

Query: 684  VQDELRIKENELRALEEELAGLKN---------------------TAEKYRQLKQQWEMK 722
             +D L  + + L + EEEL  ++N                      A +  +++Q   +K
Sbjct: 619  TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVK 678

Query: 723  TEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQR----KAEEKYEVLEN 778
             ++  LL+ +LQ    +K +E      K + +  + LK+  E+Q+     +E+  + +  
Sbjct: 679  DDKIRLLEEQLQHEISNKMEE-----FKILNDQNKALKS--EVQKLQTLVSEQPNKDVVE 731

Query: 779  KMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELK---REHTS 835
            +M+    E++ +LK  ++ L+    +     +++   + E  ++T E+++LK    +  S
Sbjct: 732  QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791

Query: 836  YKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAE 895
            +   +E + + I  +E   ++ + E     E +  A +E T Q  + +            
Sbjct: 792  FASLVEELKKVI--HEKDGKIKSVEELLEAELLKVANKEKTVQLSITS------------ 837

Query: 896  VAKHKEQNNDSQLKIKELDHNISKH-KREAEDGAAKVSKMLKDYDWINAERHLFGQPNSA 954
                K Q   + LK KE   N  K    E E   A   K L+D    N       Q  + 
Sbjct: 838  ----KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 893

Query: 955  YDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVEN--DK 1012
            ++ K  +     + L+ +  +KEK      + AM      +ER +DL  K +++++  D+
Sbjct: 894  HNLKEASSASQFEELEIV--LKEKENELKRLEAM-----LKERESDLSSKTQLLQDVQDE 946

Query: 1013 SKIL-TTIEDLDQKKNQ 1028
            +K+  + IE L Q+  Q
Sbjct: 947  NKLFKSQIEQLKQQNYQ 963


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  105 bits (262), Expect = 3e-22
 Identities = 189/862 (21%), Positives = 350/862 (40%), Gaps = 126/862 (14%)

Query: 154  LNMKPPEILSMIEEAAGTRMYEYKKIA-AQKTIEKKEAKLKEIKTILEEEITPTIQKLKE 212
            L  K  E+ + IEE       E    A A+K       +L+EI   LEE    T  +++ 
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169

Query: 213  ERSSYLEYQKVMREIEHLSRLYIAYQFLLAE---DTKVRSAEELKEMQDKVIKLQEELSE 269
             +    E+QK+ R++E  +  + A    L +   D+     E++  +Q    KL++E SE
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229

Query: 270  NDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAF-DLKKKNLACEE 328
               +I  L   +E + K K      + R+LED L+E +    + Q    DL         
Sbjct: 1230 MKMEIDDLASNVETVSKAKGN-LEKMCRTLEDQLSELKSKEEEQQRLINDLT-------- 1280

Query: 329  SKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLS 388
            ++R  L+    E S+ L  KE  V +++ G  A  +   +    L               
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL--------------- 1325

Query: 389  SNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD- 447
              E  A+  LA  + + ++D    + + ++ Q      Q+ L     EV +  + Y  D 
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385

Query: 448  ----QEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARF 503
                +E  EA K+L ++L+A  + +     K  SL + +++L  ++  L    E   A  
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAAC 1445

Query: 504  PNLRFAYKDPEK---NWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
              L    ++ +K    W + C +   A L + +  + +   EL   +  Y   +D   T 
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEE-THAELEASQKEARSLGTELFKIKNAYEESLDQLET- 1503

Query: 561  KKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVH----VALSLVEYKPEL 616
                    LKR       NK   + I+  T ++A+   G   +H    +   + + K EL
Sbjct: 1504 --------LKRE------NKNLQQEISDLTEQIAE---GGKRIHELEKIKKQVEQEKCEL 1546

Query: 617  QKAMEFVF-------GTTFVCDNMDNAKKVAFDKRIMTRTVTLGG-------DVFDPHGT 662
            Q A+E          G         N  K   D++I  +   +          V     T
Sbjct: 1547 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606

Query: 663  LSGGARSQAASILTKFQELKDVQDELRIKENEL-RALEEELAGLKNTA------------ 709
            L    RS+  +I  K ++++   +E+ I+ N   R   E L   +NT             
Sbjct: 1607 LDAEIRSRNDAIRLK-KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665

Query: 710  --EKYRQLKQQWEMKTEEADLLQTKLQQ----------SSYHKQQEELDALKKT--IEES 755
                   LK+Q  M    A+LLQ ++++          S    +QE LDA ++   +   
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725

Query: 756  EETLKNTK-----EIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASS- 809
              +L NTK     +I +   E  ++L+ + +NAE + ++ + DA    +  K + D S+ 
Sbjct: 1726 NTSLINTKKKLETDISQMQGEMEDILQ-EARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784

Query: 810  --KKMKEKQQEVEAITLELEELKR-EHTSYKQQLEAVNEAIKSYESQIEVMA---AEVAK 863
              +  K  +Q V+ + L L+E ++      K+Q++ +   ++  E ++E      AE  K
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVK 1844

Query: 864  NKESVNKAQEEVTKQ-----KEVITAQDTV------IKAKYAEVAKHKEQNNDSQLKIKE 912
                  +  +E+T Q     K ++  QD V      +K+   +  + +EQ+N +  K ++
Sbjct: 1845 GLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRK 1904

Query: 913  LDHNISKHKREAEDGAAKVSKM 934
            L H + + +  A+   ++V+K+
Sbjct: 1905 LQHELEEAEERADIAESQVNKL 1926



 Score =  100 bits (248), Expect = 1e-20
 Identities = 178/950 (18%), Positives = 385/950 (40%), Gaps = 115/950 (12%)

Query: 149  RITKVLNMKPPEILSMIEEAAG-----TRMYEYKKI---AAQKTIEKKEAKLKEIKTI-- 198
            ++ K  +    ++ ++ EE AG      ++ + KK    A Q+T++  +A+  ++ T+  
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028

Query: 199  ----LEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AEDTKVRSAEEL 253
                LE+++      L++E+   ++ ++  R++E    L +A + ++  E+ K +  E+L
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE--GDLKLAQESIMDIENEKQQLDEKL 1086

Query: 254  KEMQDKVIKLQEELSEND-------KKIKALNHEIEELEK----------RKDKETGGIL 296
            K+ + ++  LQ ++ +         KKIK L   IEELE+          + +K+   + 
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKE----V 352
            R LE+     +     + +  ++ KK  A  +  R++LE+  ++   T A   K+    V
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206

Query: 353  KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS------NEDGAEATLAGQMMACK 406
             ++ + +  LQ    K  +  +  +   + +++ + +      N +    TL  Q+   K
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266

Query: 407  NDISKAQT-----EAKQAQMKLKHAQ--QELKNKQAEVKKMDSGYRKDQEALEAVKRLKE 459
            +   + Q       A++ +++ +  +  ++L  K+A V ++  G    Q   + ++ LK 
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRG---KQAFTQQIEELKR 1323

Query: 460  KLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKN--- 516
            +LE E+K  N       +L    +    D   L+E YE        L+ A          
Sbjct: 1324 QLEEEIKAKN-------ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376

Query: 517  WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTII 576
            W        +     +++     A  L A E     V     + +K  +R + +    ++
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436

Query: 577  PLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA 636
             + + +A C A   L   Q               E   EL+ + +           + NA
Sbjct: 1437 DVERTNAACAA---LDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493

Query: 637  KKVAFDK--RIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENE 694
             + + D+   +      L  ++ D    ++ G +        +  EL+ ++ ++  ++ E
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGK--------RIHELEKIKKQVEQEKCE 1545

Query: 695  LRA-LEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIE 753
            L+A LEE  A L++   K  +++ +      E D            ++ EE+D LK+   
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVD--------RKIAEKDEEIDQLKRNHI 1597

Query: 754  ESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMK 813
               E++++T + + ++      L+ KM       E +L + + +L+ A   A  + +  +
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKM-------EGDLNEMEIQLNHANRMAAEALRNYR 1650

Query: 814  EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQE 873
              Q  ++   + L++  R     K+QL  V       +++IE + A + + + S   A++
Sbjct: 1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710

Query: 874  EVTKQKEVI----TAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
            E+    E +    T   ++I  K        +   + +  ++E  +   K K+   D A 
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770

Query: 930  KVSKMLKDYDW-INAERHLFGQPNSAYDFKTNNP-------KEAGQRLQKLQEMKEKLGR 981
               ++ K+ D   + ER       +  D +           K   +++QKL+    +L  
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEG 1830

Query: 982  NV------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQK 1025
             V      N  A+  L + E R  +L  +    E D+  IL  ++DL  K
Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQ---TEEDRKNIL-RLQDLVDK 1876



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 163/837 (19%), Positives = 341/837 (40%), Gaps = 95/837 (11%)

Query: 238  QFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDK--ETGGI 295
            +F   +D   +S  + KE+++K++ L +E ++   +++A    + + E+R D+  +T   
Sbjct: 861  EFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQ 920

Query: 296  LRSLEDALAEAQRVNTKSQSAFDLKKKNL--ACEESKR--KELEKNMVEDSKTLAAKEKE 351
            L +    + E      +  +    KK+ L   C E K+   +LE  + +  K   A E +
Sbjct: 921  LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980

Query: 352  VKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISK 411
            VK +T+ +  L E   K  +   A Q+        L + ED              N ++K
Sbjct: 981  VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV------------NTLTK 1028

Query: 412  AQTEAKQAQMKLKHAQQELKNKQAEV----KKMDSGYRKDQEALEAVKRLKEKLEAEMKK 467
            A+ + +Q    L+ + ++ K  + ++    +K++   +  QE++  ++  K++L+ ++KK
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088

Query: 468  LNYEENKEESLLEKRR----QLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
              +E +  +S +E  +    QL + I  L+   E L       R +    EK    +  +
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ-RSDLSR 1147

Query: 524  GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRRYTIIPLNK 580
             L      +++    T+ ++   ++        E   +K+   LE   L+   T   L K
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKK-------REAEFQKMRRDLEEATLQHEATAATLRK 1200

Query: 581  ISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVA 640
              A  +A    ++       DN    L  V+ K E +K+ E       +  N++   K  
Sbjct: 1201 KHADSVAELGEQI-------DN----LQRVKQKLEKEKS-EMKMEIDDLASNVETVSKAK 1248

Query: 641  FDKRIMTRTVTLGGDVFDPHGTLSGGARSQAA---SILTKFQELKDVQDELRIKENELRA 697
             +   M RT+       D    L      Q      +  +   L+    E   + +E  A
Sbjct: 1249 GNLEKMCRTLE------DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302

Query: 698  LEEELA-GLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
            L  +L+ G +   ++  +LK+Q E + +  + L   LQ S     + + D L++  EE +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS-----RHDCDLLREQYEEEQ 1357

Query: 757  ETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKL-----------DCAKTKA 805
            E+    +    KA  +      K +    +R  EL++A+KKL           +    K 
Sbjct: 1358 ESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC 1417

Query: 806  DASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEV-AKN 864
             +  K  +  Q EVE + L++E       +  ++    ++ +  ++ + E   AE+ A  
Sbjct: 1418 ASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477

Query: 865  KES---------VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDH 915
            KE+         +  A EE   Q E +  ++   K    E++   EQ  +   +I    H
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKREN---KNLQQEISDLTEQIAEGGKRI----H 1530

Query: 916  NISKHKREAEDGAAKVSKMLKDYD--WINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ 973
             + K K++ E    ++   L++ +    + E  +          K+   ++  ++ +++ 
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590

Query: 974  EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
            ++K    R V      +  E   R ND ++ K+ +E D +++   +   ++   +AL
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSR-NDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 210/1011 (20%), Positives = 419/1011 (41%), Gaps = 202/1011 (19%)

Query: 146  MQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEE---- 201
            ++ ++  +L  K    L +  EA G    E +     KT  + EAK+KE+    E+    
Sbjct: 879  LEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 938

Query: 202  --EITPTIQKLKEERSSY--------LEYQKVMRE-------IEHLSRLYIAYQFLLAED 244
              E+T   +KL++E S          L   KV +E       +++L+         +A+ 
Sbjct: 939  NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL 998

Query: 245  TKVRSA---------EELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
            TK + A         ++L+  +DKV  L +   + ++++  L   +E+ EK+   +    
Sbjct: 999  TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ-EKKLRMDLERA 1057

Query: 296  LRSLEDALAEAQRVNTKSQSAFDLK-KKNLACEESKRKELE----KNMVEDSKTLAAK-E 349
             R LE  L  AQ      +S  D++ +K    E+ K+KE E    ++ +ED + L  + +
Sbjct: 1058 KRKLEGDLKLAQ------ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111

Query: 350  KEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS----NEDGAEATLA------ 399
            K++K++   +  L+E    +  + A A++  + +S  L       E+   AT A      
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK 1171

Query: 400  ---GQMMACKNDISKA--QTEAKQAQMKLKHA----------------QQELKNKQAEVK 438
                +    + D+ +A  Q EA  A ++ KHA                +Q+L+ +++E+K
Sbjct: 1172 KREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK 1231

Query: 439  KMDSGYRKDQEALEAVKRLKEK----LEAEMKKLNYEENKEESLLE----KRRQLSRDIG 490
                    + E +   K   EK    LE ++ +L  +E +++ L+     +R +L  + G
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291

Query: 491  ---RLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
               R  +  EAL+++    + A+    +   R             ++  A  AL      
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL----------EEEIKAKNALAHALQS 1341

Query: 548  RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
              ++  +  E   ++   + EL+R      L+K +       T      +   + +  A 
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQR-----ALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396

Query: 608  SLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGA 667
              +  +  LQ A E V      C +++  K     +R+      L  DV   +   +   
Sbjct: 1397 KKLAQR--LQAAEEHVEAVNAKCASLEKTK-----QRLQNEVEDLMLDVERTNAACAALD 1449

Query: 668  RSQA--ASILTKF-QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTE 724
            + Q     IL ++ Q+ ++   EL   + E R+L  EL  +KN  E+   L Q   +K E
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE--SLDQLETLKRE 1507

Query: 725  EADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAE 784
              +L             Q+E+  L + I E  + +   ++I+++ E++   L+  ++ AE
Sbjct: 1508 NKNL-------------QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554

Query: 785  AERERE---LKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLE 841
            A  E E   +   Q +L+  K++ D   +K+ EK +E+       ++LKR H    + ++
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVD---RKIAEKDEEI-------DQLKRNHIRIVESMQ 1604

Query: 842  AV--------NEAIKSYE------SQIEV-------MAAEVAKNKESVN----------- 869
            +         N+AI+  +      +++E+       MAAE  +N  +             
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664

Query: 870  ---KAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAED 926
               ++QE++ +Q  ++  +  +++A+  E+    EQ   S+ KI E         +E  D
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSR-KIAE---------QELLD 1714

Query: 927  GAAKVSKM-LKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNM 985
             + +V  +  ++   IN ++ L          +T+  +  G+    LQE      RN   
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKL----------ETDISQMQGEMEDILQE-----ARNAEE 1759

Query: 986  RAMNVLTEAEERYNDLMKKKRI---VENDKSKILTTIEDLDQKKNQALNIA 1033
            +A   +T+A     +L K++     +E  K  +  T++DL  + ++A  +A
Sbjct: 1760 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 152/764 (19%), Positives = 304/764 (39%), Gaps = 102/764 (13%)

Query: 304  AEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQ 363
            AE ++     +  F   K  LA  E+KRKELE+ MV   K     + +V+   +GL   +
Sbjct: 849  AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908

Query: 364  EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEAT-----LAGQMMACKNDISKAQTEAK 417
            E  ++  +     +     V+      E+  AE T     L  +    K DI   +    
Sbjct: 909  ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968

Query: 418  QAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEES 477
            + + +    + ++KN   E+  +D    K     +  K L+E  +  +  L  EE+K  +
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAK---LTKEKKALQEAHQQTLDDLQAEEDKVNT 1025

Query: 478  LLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
            L + + +L + +  L+ + E       +L  A +  E +     +K    S++ +++   
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD-----LKLAQESIMDIENEKQ 1080

Query: 538  TTALELVAGE----RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRV 593
                +L   E     L + + D +  G +L ++           + ++ AR    E    
Sbjct: 1081 QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKK-----------IKELQARIEELEEEIE 1129

Query: 594  AQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK-RIMTRTVTL 652
            A+             L     E+ + +E   G T     M+  ++  F K R      TL
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189

Query: 653  GGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENEL----------------- 695
              +      TL        A +  +   L+ V+ +L  +++E+                 
Sbjct: 1190 QHEA--TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKA 1247

Query: 696  --------RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDA 747
                    R LE++L+ LK+  E+ ++L       T +   LQT  +   + +Q +E +A
Sbjct: 1248 KGNLEKMCRTLEDQLSELKSKEEEQQRLIND---LTAQRGRLQT--ESGEFSRQLDEKEA 1302

Query: 748  LKKTIEESEETL-KNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKAD 806
            L   +   ++   +  +E++R+ EE     E K KNA A     L+ ++   D  + + +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEE-----EIKAKNALA---HALQSSRHDCDLLREQYE 1354

Query: 807  ASSKKMKEKQQEVEAITLELEELKREH-TSYKQQLEAVNEAIKSYESQIEVMAAEVAKNK 865
               +   E Q+ +     E+ + + ++ T   Q+ E + EA K    +++  AAE     
Sbjct: 1355 EEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ--AAEEHVEA 1412

Query: 866  ESVNKAQEEVTKQKEVITAQDTVI---KAKYAEVAKHKEQNNDSQLKIKELDHNISKHKR 922
             +   A  E TKQ+     +D ++   +   A  A  K+Q N         D  +++ K+
Sbjct: 1413 VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN--------FDKILAEWKQ 1464

Query: 923  EAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRN 982
            + E+  A++    K+   +  E            FK  N  E  + L +L+ +K +  +N
Sbjct: 1465 KCEETHAELEASQKEARSLGTEL-----------FKIKNAYE--ESLDQLETLKRE-NKN 1510

Query: 983  VNMRAMNV---LTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
            +     ++   + E  +R ++L K K+ VE +K ++   +E+ +
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 86/430 (20%), Positives = 178/430 (41%), Gaps = 88/430 (20%)

Query: 683  DVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ--QSSYHK 740
            D++   R  E +L+  +E +  ++N  +   QL ++ + K  E   LQ+K++  Q+   +
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQ---QLDEKLKKKEFEISNLQSKIEDEQALGIQ 1109

Query: 741  QQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDC 800
             Q+++  L+  IEE EE ++  +  + KAE++            ++  REL++  ++L+ 
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQ-----------RSDLSRELEEISERLEE 1158

Query: 801  AKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK------------------QQLEA 842
            A     A  +  K+++ E + +  +LEE   +H +                      L+ 
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218

Query: 843  VNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAK---------- 892
            V + ++  +S++++   ++A N E+V+KA+  + K    +  Q + +K+K          
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278

Query: 893  --------YAEVAKHKEQNNDSQLKIKELD-------HNISKHKREAEDG-------AAK 930
                      E  +   Q ++ +  + +L          I + KR+ E+        A  
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338

Query: 931  VSKMLKDYDWI------------NAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEK 978
            +     D D +              +R L         ++T    +A QR ++L+E K+K
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398

Query: 979  LGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIED--LDQKKNQALNIAWQK 1036
            L +         L  AEE    +  K   +E  K ++   +ED  LD ++  A   A  K
Sbjct: 1399 LAQR--------LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK 1450

Query: 1037 VNKDFGSIFS 1046
              ++F  I +
Sbjct: 1451 KQRNFDKILA 1460



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 89/408 (21%), Positives = 175/408 (42%), Gaps = 75/408 (18%)

Query: 149  RITKVLNMKPPEILSMIEEAAGTRMYEYKKIAA-------------QKTIEKKEA--KLK 193
            +I K +  +  E+ + +EEA  +  +E  KI               +K  EK E   +LK
Sbjct: 1534 KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1593

Query: 194  EIKTILEEEITPTIQKLKEERSSYLEYQKVMR--------EIEHLSRL-------YIAYQ 238
                 + E +  T+      R+  +  +K M         ++ H +R+       Y   Q
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653

Query: 239  FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELE---KRKDKETGGI 295
             +L +DT++   + L+  +D    L+E+L+  +++   L  EIEEL    ++ ++     
Sbjct: 1654 GIL-KDTQIHLDDALRSQED----LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708

Query: 296  LRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKI 355
             + L DA    Q ++T++ S  + KKK L  + S+ +   ++++++++   A+EK  K I
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKK-LETDISQMQGEMEDILQEARN--AEEKAKKAI 1765

Query: 356  TDGLHALQEASNK-DAEA-LAAAQQHFNAVSAGLSSNEDGAEA-TLAG---QMMACKNDI 409
            TD     +E   + D  A L   +++       L    D AE   L G   Q+   +  +
Sbjct: 1766 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1825

Query: 410  SKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMK--K 467
             + + E +  Q +   A + L+  +  VK++     +D++ +  ++ L +KL+A++K  K
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885

Query: 468  LNYEENKE--------------------------ESLLEKRRQLSRDI 489
               EE +E                          ES + K R  SR++
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  105 bits (262), Expect = 3e-22
 Identities = 189/862 (21%), Positives = 350/862 (40%), Gaps = 126/862 (14%)

Query: 154  LNMKPPEILSMIEEAAGTRMYEYKKIA-AQKTIEKKEAKLKEIKTILEEEITPTIQKLKE 212
            L  K  E+ + IEE       E    A A+K       +L+EI   LEE    T  +++ 
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169

Query: 213  ERSSYLEYQKVMREIEHLSRLYIAYQFLLAE---DTKVRSAEELKEMQDKVIKLQEELSE 269
             +    E+QK+ R++E  +  + A    L +   D+     E++  +Q    KL++E SE
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229

Query: 270  NDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAF-DLKKKNLACEE 328
               +I  L   +E + K K      + R+LED L+E +    + Q    DL         
Sbjct: 1230 MKMEIDDLASNVETVSKAKGN-LEKMCRTLEDQLSELKSKEEEQQRLINDLT-------- 1280

Query: 329  SKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLS 388
            ++R  L+    E S+ L  KE  V +++ G  A  +   +    L               
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL--------------- 1325

Query: 389  SNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD- 447
              E  A+  LA  + + ++D    + + ++ Q      Q+ L     EV +  + Y  D 
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385

Query: 448  ----QEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARF 503
                +E  EA K+L ++L+A  + +     K  SL + +++L  ++  L    E   A  
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAAC 1445

Query: 504  PNLRFAYKDPEK---NWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
              L    ++ +K    W + C +   A L + +  + +   EL   +  Y   +D   T 
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEE-THAELEASQKEARSLGTELFKIKNAYEESLDQLET- 1503

Query: 561  KKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVH----VALSLVEYKPEL 616
                    LKR       NK   + I+  T ++A+   G   +H    +   + + K EL
Sbjct: 1504 --------LKRE------NKNLQQEISDLTEQIAE---GGKRIHELEKIKKQVEQEKCEL 1546

Query: 617  QKAMEFVF-------GTTFVCDNMDNAKKVAFDKRIMTRTVTLGG-------DVFDPHGT 662
            Q A+E          G         N  K   D++I  +   +          V     T
Sbjct: 1547 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606

Query: 663  LSGGARSQAASILTKFQELKDVQDELRIKENEL-RALEEELAGLKNTA------------ 709
            L    RS+  +I  K ++++   +E+ I+ N   R   E L   +NT             
Sbjct: 1607 LDAEIRSRNDAIRLK-KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665

Query: 710  --EKYRQLKQQWEMKTEEADLLQTKLQQ----------SSYHKQQEELDALKKT--IEES 755
                   LK+Q  M    A+LLQ ++++          S    +QE LDA ++   +   
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725

Query: 756  EETLKNTK-----EIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASS- 809
              +L NTK     +I +   E  ++L+ + +NAE + ++ + DA    +  K + D S+ 
Sbjct: 1726 NTSLINTKKKLETDISQMQGEMEDILQ-EARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784

Query: 810  --KKMKEKQQEVEAITLELEELKR-EHTSYKQQLEAVNEAIKSYESQIEVMA---AEVAK 863
              +  K  +Q V+ + L L+E ++      K+Q++ +   ++  E ++E      AE  K
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVK 1844

Query: 864  NKESVNKAQEEVTKQ-----KEVITAQDTV------IKAKYAEVAKHKEQNNDSQLKIKE 912
                  +  +E+T Q     K ++  QD V      +K+   +  + +EQ+N +  K ++
Sbjct: 1845 GLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRK 1904

Query: 913  LDHNISKHKREAEDGAAKVSKM 934
            L H + + +  A+   ++V+K+
Sbjct: 1905 LQHELEEAEERADIAESQVNKL 1926



 Score =  100 bits (248), Expect = 1e-20
 Identities = 178/950 (18%), Positives = 385/950 (40%), Gaps = 115/950 (12%)

Query: 149  RITKVLNMKPPEILSMIEEAAG-----TRMYEYKKI---AAQKTIEKKEAKLKEIKTI-- 198
            ++ K  +    ++ ++ EE AG      ++ + KK    A Q+T++  +A+  ++ T+  
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028

Query: 199  ----LEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AEDTKVRSAEEL 253
                LE+++      L++E+   ++ ++  R++E    L +A + ++  E+ K +  E+L
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE--GDLKLAQESIMDIENEKQQLDEKL 1086

Query: 254  KEMQDKVIKLQEELSEND-------KKIKALNHEIEELEK----------RKDKETGGIL 296
            K+ + ++  LQ ++ +         KKIK L   IEELE+          + +K+   + 
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKE----V 352
            R LE+     +     + +  ++ KK  A  +  R++LE+  ++   T A   K+    V
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206

Query: 353  KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS------NEDGAEATLAGQMMACK 406
             ++ + +  LQ    K  +  +  +   + +++ + +      N +    TL  Q+   K
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266

Query: 407  NDISKAQT-----EAKQAQMKLKHAQ--QELKNKQAEVKKMDSGYRKDQEALEAVKRLKE 459
            +   + Q       A++ +++ +  +  ++L  K+A V ++  G    Q   + ++ LK 
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRG---KQAFTQQIEELKR 1323

Query: 460  KLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKN--- 516
            +LE E+K  N       +L    +    D   L+E YE        L+ A          
Sbjct: 1324 QLEEEIKAKN-------ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376

Query: 517  WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTII 576
            W        +     +++     A  L A E     V     + +K  +R + +    ++
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436

Query: 577  PLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA 636
             + + +A C A   L   Q               E   EL+ + +           + NA
Sbjct: 1437 DVERTNAACAA---LDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493

Query: 637  KKVAFDK--RIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENE 694
             + + D+   +      L  ++ D    ++ G +        +  EL+ ++ ++  ++ E
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGK--------RIHELEKIKKQVEQEKCE 1545

Query: 695  LRA-LEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIE 753
            L+A LEE  A L++   K  +++ +      E D            ++ EE+D LK+   
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVD--------RKIAEKDEEIDQLKRNHI 1597

Query: 754  ESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMK 813
               E++++T + + ++      L+ KM       E +L + + +L+ A   A  + +  +
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKM-------EGDLNEMEIQLNHANRMAAEALRNYR 1650

Query: 814  EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQE 873
              Q  ++   + L++  R     K+QL  V       +++IE + A + + + S   A++
Sbjct: 1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710

Query: 874  EVTKQKEVI----TAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
            E+    E +    T   ++I  K        +   + +  ++E  +   K K+   D A 
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770

Query: 930  KVSKMLKDYDW-INAERHLFGQPNSAYDFKTNNP-------KEAGQRLQKLQEMKEKLGR 981
               ++ K+ D   + ER       +  D +           K   +++QKL+    +L  
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEG 1830

Query: 982  NV------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQK 1025
             V      N  A+  L + E R  +L  +    E D+  IL  ++DL  K
Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQ---TEEDRKNIL-RLQDLVDK 1876



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 163/837 (19%), Positives = 341/837 (40%), Gaps = 95/837 (11%)

Query: 238  QFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDK--ETGGI 295
            +F   +D   +S  + KE+++K++ L +E ++   +++A    + + E+R D+  +T   
Sbjct: 861  EFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQ 920

Query: 296  LRSLEDALAEAQRVNTKSQSAFDLKKKNL--ACEESKR--KELEKNMVEDSKTLAAKEKE 351
            L +    + E      +  +    KK+ L   C E K+   +LE  + +  K   A E +
Sbjct: 921  LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980

Query: 352  VKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISK 411
            VK +T+ +  L E   K  +   A Q+        L + ED              N ++K
Sbjct: 981  VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV------------NTLTK 1028

Query: 412  AQTEAKQAQMKLKHAQQELKNKQAEV----KKMDSGYRKDQEALEAVKRLKEKLEAEMKK 467
            A+ + +Q    L+ + ++ K  + ++    +K++   +  QE++  ++  K++L+ ++KK
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088

Query: 468  LNYEENKEESLLEKRR----QLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
              +E +  +S +E  +    QL + I  L+   E L       R +    EK    +  +
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ-RSDLSR 1147

Query: 524  GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRRYTIIPLNK 580
             L      +++    T+ ++   ++        E   +K+   LE   L+   T   L K
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKK-------REAEFQKMRRDLEEATLQHEATAATLRK 1200

Query: 581  ISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVA 640
              A  +A    ++       DN    L  V+ K E +K+ E       +  N++   K  
Sbjct: 1201 KHADSVAELGEQI-------DN----LQRVKQKLEKEKS-EMKMEIDDLASNVETVSKAK 1248

Query: 641  FDKRIMTRTVTLGGDVFDPHGTLSGGARSQAA---SILTKFQELKDVQDELRIKENELRA 697
             +   M RT+       D    L      Q      +  +   L+    E   + +E  A
Sbjct: 1249 GNLEKMCRTLE------DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302

Query: 698  LEEELA-GLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
            L  +L+ G +   ++  +LK+Q E + +  + L   LQ S     + + D L++  EE +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS-----RHDCDLLREQYEEEQ 1357

Query: 757  ETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKL-----------DCAKTKA 805
            E+    +    KA  +      K +    +R  EL++A+KKL           +    K 
Sbjct: 1358 ESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC 1417

Query: 806  DASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEV-AKN 864
             +  K  +  Q EVE + L++E       +  ++    ++ +  ++ + E   AE+ A  
Sbjct: 1418 ASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477

Query: 865  KES---------VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDH 915
            KE+         +  A EE   Q E +  ++   K    E++   EQ  +   +I    H
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKREN---KNLQQEISDLTEQIAEGGKRI----H 1530

Query: 916  NISKHKREAEDGAAKVSKMLKDYD--WINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ 973
             + K K++ E    ++   L++ +    + E  +          K+   ++  ++ +++ 
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590

Query: 974  EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
            ++K    R V      +  E   R ND ++ K+ +E D +++   +   ++   +AL
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSR-NDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 210/1011 (20%), Positives = 419/1011 (41%), Gaps = 202/1011 (19%)

Query: 146  MQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEE---- 201
            ++ ++  +L  K    L +  EA G    E +     KT  + EAK+KE+    E+    
Sbjct: 879  LEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 938

Query: 202  --EITPTIQKLKEERSSY--------LEYQKVMRE-------IEHLSRLYIAYQFLLAED 244
              E+T   +KL++E S          L   KV +E       +++L+         +A+ 
Sbjct: 939  NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL 998

Query: 245  TKVRSA---------EELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
            TK + A         ++L+  +DKV  L +   + ++++  L   +E+ EK+   +    
Sbjct: 999  TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ-EKKLRMDLERA 1057

Query: 296  LRSLEDALAEAQRVNTKSQSAFDLK-KKNLACEESKRKELE----KNMVEDSKTLAAK-E 349
             R LE  L  AQ      +S  D++ +K    E+ K+KE E    ++ +ED + L  + +
Sbjct: 1058 KRKLEGDLKLAQ------ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111

Query: 350  KEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS----NEDGAEATLA------ 399
            K++K++   +  L+E    +  + A A++  + +S  L       E+   AT A      
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK 1171

Query: 400  ---GQMMACKNDISKA--QTEAKQAQMKLKHA----------------QQELKNKQAEVK 438
                +    + D+ +A  Q EA  A ++ KHA                +Q+L+ +++E+K
Sbjct: 1172 KREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK 1231

Query: 439  KMDSGYRKDQEALEAVKRLKEK----LEAEMKKLNYEENKEESLLE----KRRQLSRDIG 490
                    + E +   K   EK    LE ++ +L  +E +++ L+     +R +L  + G
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291

Query: 491  ---RLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
               R  +  EAL+++    + A+    +   R             ++  A  AL      
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL----------EEEIKAKNALAHALQS 1341

Query: 548  RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
              ++  +  E   ++   + EL+R      L+K +       T      +   + +  A 
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQR-----ALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396

Query: 608  SLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGA 667
              +  +  LQ A E V      C +++  K     +R+      L  DV   +   +   
Sbjct: 1397 KKLAQR--LQAAEEHVEAVNAKCASLEKTK-----QRLQNEVEDLMLDVERTNAACAALD 1449

Query: 668  RSQA--ASILTKF-QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTE 724
            + Q     IL ++ Q+ ++   EL   + E R+L  EL  +KN  E+   L Q   +K E
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE--SLDQLETLKRE 1507

Query: 725  EADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAE 784
              +L             Q+E+  L + I E  + +   ++I+++ E++   L+  ++ AE
Sbjct: 1508 NKNL-------------QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554

Query: 785  AERERE---LKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLE 841
            A  E E   +   Q +L+  K++ D   +K+ EK +E+       ++LKR H    + ++
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVD---RKIAEKDEEI-------DQLKRNHIRIVESMQ 1604

Query: 842  AV--------NEAIKSYE------SQIEV-------MAAEVAKNKESVN----------- 869
            +         N+AI+  +      +++E+       MAAE  +N  +             
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664

Query: 870  ---KAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAED 926
               ++QE++ +Q  ++  +  +++A+  E+    EQ   S+ KI E         +E  D
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSR-KIAE---------QELLD 1714

Query: 927  GAAKVSKM-LKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNM 985
             + +V  +  ++   IN ++ L          +T+  +  G+    LQE      RN   
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKL----------ETDISQMQGEMEDILQE-----ARNAEE 1759

Query: 986  RAMNVLTEAEERYNDLMKKKRI---VENDKSKILTTIEDLDQKKNQALNIA 1033
            +A   +T+A     +L K++     +E  K  +  T++DL  + ++A  +A
Sbjct: 1760 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 152/764 (19%), Positives = 304/764 (39%), Gaps = 102/764 (13%)

Query: 304  AEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQ 363
            AE ++     +  F   K  LA  E+KRKELE+ MV   K     + +V+   +GL   +
Sbjct: 849  AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908

Query: 364  EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEAT-----LAGQMMACKNDISKAQTEAK 417
            E  ++  +     +     V+      E+  AE T     L  +    K DI   +    
Sbjct: 909  ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968

Query: 418  QAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEES 477
            + + +    + ++KN   E+  +D    K     +  K L+E  +  +  L  EE+K  +
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAK---LTKEKKALQEAHQQTLDDLQAEEDKVNT 1025

Query: 478  LLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
            L + + +L + +  L+ + E       +L  A +  E +     +K    S++ +++   
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD-----LKLAQESIMDIENEKQ 1080

Query: 538  TTALELVAGE----RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRV 593
                +L   E     L + + D +  G +L ++           + ++ AR    E    
Sbjct: 1081 QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKK-----------IKELQARIEELEEEIE 1129

Query: 594  AQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK-RIMTRTVTL 652
            A+             L     E+ + +E   G T     M+  ++  F K R      TL
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189

Query: 653  GGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENEL----------------- 695
              +      TL        A +  +   L+ V+ +L  +++E+                 
Sbjct: 1190 QHEA--TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKA 1247

Query: 696  --------RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDA 747
                    R LE++L+ LK+  E+ ++L       T +   LQT  +   + +Q +E +A
Sbjct: 1248 KGNLEKMCRTLEDQLSELKSKEEEQQRLIND---LTAQRGRLQT--ESGEFSRQLDEKEA 1302

Query: 748  LKKTIEESEETL-KNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKAD 806
            L   +   ++   +  +E++R+ EE     E K KNA A     L+ ++   D  + + +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEE-----EIKAKNALA---HALQSSRHDCDLLREQYE 1354

Query: 807  ASSKKMKEKQQEVEAITLELEELKREH-TSYKQQLEAVNEAIKSYESQIEVMAAEVAKNK 865
               +   E Q+ +     E+ + + ++ T   Q+ E + EA K    +++  AAE     
Sbjct: 1355 EEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ--AAEEHVEA 1412

Query: 866  ESVNKAQEEVTKQKEVITAQDTVI---KAKYAEVAKHKEQNNDSQLKIKELDHNISKHKR 922
             +   A  E TKQ+     +D ++   +   A  A  K+Q N         D  +++ K+
Sbjct: 1413 VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN--------FDKILAEWKQ 1464

Query: 923  EAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRN 982
            + E+  A++    K+   +  E            FK  N  E  + L +L+ +K +  +N
Sbjct: 1465 KCEETHAELEASQKEARSLGTEL-----------FKIKNAYE--ESLDQLETLKRE-NKN 1510

Query: 983  VNMRAMNV---LTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
            +     ++   + E  +R ++L K K+ VE +K ++   +E+ +
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 86/430 (20%), Positives = 178/430 (41%), Gaps = 88/430 (20%)

Query: 683  DVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ--QSSYHK 740
            D++   R  E +L+  +E +  ++N  +   QL ++ + K  E   LQ+K++  Q+   +
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQ---QLDEKLKKKEFEISNLQSKIEDEQALGIQ 1109

Query: 741  QQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDC 800
             Q+++  L+  IEE EE ++  +  + KAE++            ++  REL++  ++L+ 
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQ-----------RSDLSRELEEISERLEE 1158

Query: 801  AKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK------------------QQLEA 842
            A     A  +  K+++ E + +  +LEE   +H +                      L+ 
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218

Query: 843  VNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAK---------- 892
            V + ++  +S++++   ++A N E+V+KA+  + K    +  Q + +K+K          
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278

Query: 893  --------YAEVAKHKEQNNDSQLKIKELD-------HNISKHKREAEDG-------AAK 930
                      E  +   Q ++ +  + +L          I + KR+ E+        A  
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338

Query: 931  VSKMLKDYDWI------------NAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEK 978
            +     D D +              +R L         ++T    +A QR ++L+E K+K
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398

Query: 979  LGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIED--LDQKKNQALNIAWQK 1036
            L +         L  AEE    +  K   +E  K ++   +ED  LD ++  A   A  K
Sbjct: 1399 LAQR--------LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK 1450

Query: 1037 VNKDFGSIFS 1046
              ++F  I +
Sbjct: 1451 KQRNFDKILA 1460



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 89/408 (21%), Positives = 175/408 (42%), Gaps = 75/408 (18%)

Query: 149  RITKVLNMKPPEILSMIEEAAGTRMYEYKKIAA-------------QKTIEKKEA--KLK 193
            +I K +  +  E+ + +EEA  +  +E  KI               +K  EK E   +LK
Sbjct: 1534 KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1593

Query: 194  EIKTILEEEITPTIQKLKEERSSYLEYQKVMR--------EIEHLSRL-------YIAYQ 238
                 + E +  T+      R+  +  +K M         ++ H +R+       Y   Q
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653

Query: 239  FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELE---KRKDKETGGI 295
             +L +DT++   + L+  +D    L+E+L+  +++   L  EIEEL    ++ ++     
Sbjct: 1654 GIL-KDTQIHLDDALRSQED----LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708

Query: 296  LRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKI 355
             + L DA    Q ++T++ S  + KKK L  + S+ +   ++++++++   A+EK  K I
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKK-LETDISQMQGEMEDILQEARN--AEEKAKKAI 1765

Query: 356  TDGLHALQEASNK-DAEA-LAAAQQHFNAVSAGLSSNEDGAEA-TLAG---QMMACKNDI 409
            TD     +E   + D  A L   +++       L    D AE   L G   Q+   +  +
Sbjct: 1766 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1825

Query: 410  SKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMK--K 467
             + + E +  Q +   A + L+  +  VK++     +D++ +  ++ L +KL+A++K  K
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885

Query: 468  LNYEENKE--------------------------ESLLEKRRQLSRDI 489
               EE +E                          ES + K R  SR++
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  104 bits (260), Expect = 4e-22
 Identities = 166/867 (19%), Positives = 360/867 (41%), Gaps = 115/867 (13%)

Query: 238  QFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILR 297
            +F   +D   +S  + KE+++K++ L +E ++   +++A +  + + E+R D+    +++
Sbjct: 856  EFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQ----LIK 911

Query: 298  SLEDALAEAQRVNTKSQSAFDL------KKKNL--ACEESKR--KELEKNMVEDSKTLAA 347
            +     A+ + V  +++   ++      KK+ L   C E K+   +LE  + +  K   A
Sbjct: 912  AKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 971

Query: 348  KEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKN 407
             E +VK +T+ L  L E   K      A Q+        L + ED              N
Sbjct: 972  TENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKV------------N 1019

Query: 408  DISKAQTEAKQAQMKLKHAQQELKNKQAEV----KKMDSGYRKDQEALEAVKRLKEKLEA 463
             ++K +++ +Q    L+ + ++ K  + ++    +K++   +  QE++  ++  K++L+ 
Sbjct: 1020 SLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079

Query: 464  EMKKLNYEENKEESLLEKRR----QLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNR 519
             +KK ++E  + +S +E  +    Q  + I  L+   E L       R      EK    
Sbjct: 1080 RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQ-RS 1138

Query: 520  NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLN 579
            +  + L      +++    T+ ++   ++     +      ++ LE   L+    +  L 
Sbjct: 1139 DYARELEELSERLEEAGGVTSTQIELNKKREAEFLKL----RRDLEEATLQHEAMVAALR 1194

Query: 580  KISARCIAP-----ETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMD 634
            K  A  +A      + L+  +  +  +     L + +    ++   +       +C  ++
Sbjct: 1195 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLE 1254

Query: 635  NAKKVAFDK----------------RIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKF 678
            +    A  K                R+ T    L   + +    +S  +RS+ A      
Sbjct: 1255 DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT---- 1310

Query: 679  QELKDVQDELRIKENELRALEEELAGLKNTAEKYR-QLKQQWEMKTEEADLLQTKLQQSS 737
            Q+ ++++ +L  +     AL   L   ++  +  R Q +++ E K E    L     + +
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370

Query: 738  YHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERER---ELKDA 794
              + + E DA+++T EE EE  K   +  + +EE+ E +  K  + E  ++R   E++D 
Sbjct: 1371 QWRTKYETDAIQRT-EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL 1429

Query: 795  QKKLDCAKTKADASSKKMK--------------EKQQEVEA-------ITLELEELKREH 833
               ++ A + A A  KK +              E Q E+EA       ++ EL +LK  +
Sbjct: 1430 MVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAY 1489

Query: 834  TSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKY 893
                 QLE V    K+ E +I  +  ++A+N +++++  E+  KQ E+  A D  +  + 
Sbjct: 1490 EEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL-EKSRKQIELEKA-DIQLALEE 1547

Query: 894  AEVAKHKEQ-------------NNDSQLKIKELDHNISKHKREAEDGAAKVSKML----- 935
            AE A   E+              ++   KI E D  I + KR  +     +   L     
Sbjct: 1548 AEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR 1607

Query: 936  KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAE 995
               + I  ++ + G  N      ++  ++A + L+ L+ ++ +L ++  +     L +A 
Sbjct: 1608 SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL-KDTQLH----LDDAL 1662

Query: 996  ERYNDLMKKKRIVENDKSKILTTIEDL 1022
                DL ++  IVE   + +   +E+L
Sbjct: 1663 RGQEDLKEQLAIVERRANLLQAEVEEL 1689



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 189/886 (21%), Positives = 353/886 (39%), Gaps = 143/886 (16%)

Query: 131  FCSVGLNVNNPHFLIMQ-GRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE 189
            +C +   V +   L +Q  +  K L  +  E+   IE    TR     K   Q++   +E
Sbjct: 1088 YCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRA----KTEKQRSDYARE 1143

Query: 190  AKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAE---DTK 246
              L+E+   LEE    T  +++  +    E+ K+ R++E  +  + A    L +   D+ 
Sbjct: 1144 --LEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSV 1201

Query: 247  VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEA 306
                E++  +Q    KL++E SE   +I  L+  +E + K K      I R+LED L+EA
Sbjct: 1202 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSK-ANLEKICRTLEDQLSEA 1260

Query: 307  QRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEAS 366
            +  N + Q       ++L+   +++  L+    E S+ L  KE  V +++    A  + +
Sbjct: 1261 RGKNEEIQ-------RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQT 1313

Query: 367  NKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHA 426
             +    L                 E+ A+  LA  + + ++D    + + ++ Q      
Sbjct: 1314 EELKRQL---------------EEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1358

Query: 427  QQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLS 486
            Q+ L    +EV +  + Y  D  A++  + L+E  +   ++L   E + E++  K   L 
Sbjct: 1359 QRALSKANSEVAQWRTKYETD--AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLE 1416

Query: 487  RDIGRLKETYEALLA---RFPNLRFAYKDPEKN-------WNRNCVKGLVASLISVKDTS 536
            +   RL+   E L+    R  +L  A    ++N       W   C +       S+K+ S
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE-S 1475

Query: 537  ATTALELVAGERLYNVVVDTEVTGKK---------------LLERG----ELKRRYTIIP 577
             + + EL   +  Y   +D   T K+               + E G    EL++    I 
Sbjct: 1476 RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE 1535

Query: 578  LNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAM----EFVFGTTFVCDNM 633
            L K   + +A E    A        + + L L + K E+ + +    E +          
Sbjct: 1536 LEKADIQ-LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRT 1594

Query: 634  DNAKKVAFDKRIMTRTVTLG------GDVFDPHGTLSGGARSQAASILTKFQ----ELKD 683
                + A D  + +R   +       GD+ +    LS   R QAA  L   +    +LKD
Sbjct: 1595 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANR-QAAETLKHLRSVQGQLKD 1653

Query: 684  VQ----DELRIKE-------------NELRALEEELAGLKNTAEKYRQLKQQWEMKTEE- 725
             Q    D LR +E             N L+A  EEL       E+ R+L +Q  + + E 
Sbjct: 1654 TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNER 1713

Query: 726  ADLLQTKLQQSSYHKQQEELDA--LKKTIEESEETLKNTKEIQRKAEEKYEVLENKMK-- 781
              LL T+     + K++ E D   L+  +E++    +N +E  +KA     ++  ++K  
Sbjct: 1714 VQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE 1773

Query: 782  ---NAEAER-----ERELKDAQKKLDCAKTKADASSKKMKEK------------------ 815
               +A  ER     E+ +KD Q +LD A+  A    KK  +K                  
Sbjct: 1774 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKK 1833

Query: 816  -----------QQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
                       ++ V+ +T + EE ++     +  ++ +   +KSY+ Q E    +   +
Sbjct: 1834 NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAH 1893

Query: 865  KESVNKAQ---EEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQ 907
                 KAQ   EE  ++ ++  +Q   ++AK  +    +   ++S+
Sbjct: 1894 LTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESE 1939



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 182/877 (20%), Positives = 360/877 (41%), Gaps = 143/877 (16%)

Query: 175  EYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY 234
            E  K    + ++KK+ +  ++++ +E+E T  +Q  K+ +      +++  EIE      
Sbjct: 1071 ENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE------ 1124

Query: 235  IAYQFLLAEDTKVRS--AEELKEMQDK------VIKLQEELS-ENDKKIKALNHEIEELE 285
             A +   A+  K RS  A EL+E+ ++      V   Q EL+ + + +   L  ++EE  
Sbjct: 1125 -AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEAT 1183

Query: 286  KRKDKETGGILRSLEDALAE-------AQRVN---TKSQSAFDLKKKNLACEESKRKELE 335
             + +     + +   D++AE        QRV     K +S F L+  +L+       + +
Sbjct: 1184 LQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSK 1243

Query: 336  KNMVEDSKTL-------AAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLS 388
             N+ +  +TL         K +E+++    L   +     +A  L+   +   ++ + LS
Sbjct: 1244 ANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303

Query: 389  -----------------SNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELK 431
                               E+ A+  LA  + + ++D    + + ++ Q      Q+ L 
Sbjct: 1304 RSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1363

Query: 432  NKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGR 491
               +EV +  + Y  D  A++  + L+E  +   ++L   E + E++  K   L +   R
Sbjct: 1364 KANSEVAQWRTKYETD--AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQR 1421

Query: 492  LKETYEALLA---RFPNLRFAYKDPEKN-------WNRNCVKGLVASLISVKDTSATTAL 541
            L+   E L+    R  +L  A    ++N       W   C +       S+K+ S + + 
Sbjct: 1422 LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE-SRSLST 1480

Query: 542  ELVAGERLYNVVVDTEVTGKK---------------LLERG----ELKRRYTIIPLNKIS 582
            EL   +  Y   +D   T K+               + E G    EL++    I L K  
Sbjct: 1481 ELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKAD 1540

Query: 583  ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAM----EFVFGTTFVCDNMDNAKK 638
             + +A E    A        + + L L + K E+ + +    E +              +
Sbjct: 1541 IQ-LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599

Query: 639  VAFDKRIMTRTVT------LGGDVFDPHGTLSGGARSQAASILTKFQ----ELKDVQ--- 685
             A D  + +R         + GD+ +    LS  A  QAA  L   +    +LKD Q   
Sbjct: 1600 SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLS-HANRQAAETLKHLRSVQGQLKDTQLHL 1658

Query: 686  -DELRIKE-------------NELRALEEELAGLKNTAEKYRQLKQQWEM-KTEEADLLQ 730
             D LR +E             N L+A  EEL       E+ R+L +Q  +   E   LL 
Sbjct: 1659 DDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLH 1718

Query: 731  TKLQQSSYHKQQEELD--ALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMK-----NA 783
            T+     + K++ E D   L+  +E++    +N +E  +KA     ++  ++K     +A
Sbjct: 1719 TQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSA 1778

Query: 784  EAER-----ERELKDAQKKLDCAKTKADASSKKMKEK-QQEVEAITLELEELKREHTSYK 837
              ER     E+ +KD Q +LD A+  A    KK  +K +  +  +  ELE  ++++T   
Sbjct: 1779 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNT--- 1835

Query: 838  QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVA 897
               E+V + ++ YE +++ +  +  +++++V + Q+ V K +         +K+   +  
Sbjct: 1836 ---ESV-KGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQ-------VKVKSYKRQAE 1884

Query: 898  KHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM 934
            +  EQ N    K ++  H + + +  A+   ++V+K+
Sbjct: 1885 EADEQANAHLTKFRKAQHELEEAEERADIAESQVNKL 1921



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 190/931 (20%), Positives = 370/931 (39%), Gaps = 165/931 (17%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AED 244
            E K   L + K+ LE+++      L++E+   ++ ++  R++E    L +A + +L  E+
Sbjct: 1015 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLE--GDLKLAQESILDLEN 1072

Query: 245  TKVRSAEELKEMQDKVIKLQEELSEND-------KKIKALNHEIEELEK----------R 287
             K +  E LK+   +  +LQ ++ +         KKIK L   IEELE+          +
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 1132

Query: 288  KDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAA 347
             +K+     R LE+     +     + +  +L KK  A     R++LE+  ++    +AA
Sbjct: 1133 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAA 1192

Query: 348  KEKE----VKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMM 403
              K+    V ++ + +  LQ    K    L   +  F      LSS+ +    + A    
Sbjct: 1193 LRKKHADSVAELGEQIDNLQRVKQK----LEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248

Query: 404  ACK---NDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEK 460
             C+   + +S+A+ + ++ Q  L     +    Q E  ++     + +  +  + R K+ 
Sbjct: 1249 ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA 1308

Query: 461  LEA---EMKKLNYEENKEESLLEKRRQLSR-DIGRLKETYEALLARFPNLRFAYKDPEKN 516
                  E+K+   EENK ++ L    Q SR D   L+E YE        L+ A       
Sbjct: 1309 FTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1368

Query: 517  WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTII 576
                     VA   +  +T A    E            + E   KKL +R +        
Sbjct: 1369 ---------VAQWRTKYETDAIQRTE------------ELEEAKKKLAQRLQDSEEQ--- 1404

Query: 577  PLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA 636
             +  ++A+C + E  +  Q L G   V   +  VE    L  A++               
Sbjct: 1405 -VEAVNAKCASLE--KTKQRLQG--EVEDLMVDVERANSLAAALD--------------K 1445

Query: 637  KKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELR 696
            K+  FDK +            +   +L   +RS +  +       ++  D+L   + E +
Sbjct: 1446 KQRNFDKVLAEWKTKCEESQAELEASLKE-SRSLSTELFKLKNAYEEALDQLETVKRENK 1504

Query: 697  ALEEELAGLKN-------TAEKYRQLKQQWEMKT----------------EEADLLQTKL 733
             LE+E+A L         T  +  + ++Q E++                 EEA +L+ +L
Sbjct: 1505 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL 1564

Query: 734  QQSSYHKQ--------QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKN--- 782
            + +    +         EE++ LK+  + + ET+++  + + ++  +   L+ KM+    
Sbjct: 1565 ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN 1624

Query: 783  ------AEAERER------------ELKDAQKKLDCA-------KTKADASSKKMKEKQQ 817
                  + A R+             +LKD Q  LD A       K +     ++    Q 
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684

Query: 818  EVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTK 877
            EVE +   LE+ +R     +Q+L   NE ++   +Q   +     K +  + + Q EV  
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEV-- 1742

Query: 878  QKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKD 937
                   +D    A+ AE  K K+   D+ +  +EL        ++ +D +A + +M K+
Sbjct: 1743 -------EDASRDARNAE-EKAKKAITDAAMMAEEL--------KKEQDTSAHLERMKKN 1786

Query: 938  YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQ-KLQEMKEKL--GRNVNMRAMNVLTEA 994
             +     + L  + + A        K+  Q+L+ +++E++ +L   +  N  ++  L + 
Sbjct: 1787 LE--QTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKY 1844

Query: 995  EERYNDLMKKKRIVENDKSKILTTIEDLDQK 1025
            E R  +L  +    E D+  +L  ++DL  K
Sbjct: 1845 ERRVKELTYQS---EEDRKNVL-RLQDLVDK 1871



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 154/707 (21%), Positives = 289/707 (40%), Gaps = 96/707 (13%)

Query: 163  SMIEEAAG--TRMYEYKKIAAQKTIEKKEA---KLKEIKTILEEE------ITPTIQKLK 211
            S ++  AG  +R  E K+    +    K+A   + +E+K  LEEE      +   +Q  +
Sbjct: 1279 SRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR 1338

Query: 212  EE----RSSYLEYQKVMREIEHL---SRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQ 264
             +    R  Y E Q+   E++     +   +A      E   ++  EEL+E + K   L 
Sbjct: 1339 HDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK---LA 1395

Query: 265  EELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL 324
            + L +++++++A+N +   LEK K +  G     +ED + + +R N+ + +A D K++N 
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQG----EVEDLMVDVERANSLA-AALDKKQRNF 1450

Query: 325  ACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVS 384
               +    E +    E    L A  KE + ++  L  L+ A  +  + L   ++    + 
Sbjct: 1451 ---DKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLE 1507

Query: 385  AGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQA--QMKLKHAQQELKNKQAEVKKMDS 442
              ++   D  E          + + S+ Q E ++A  Q+ L+ A+  L++++A++ ++  
Sbjct: 1508 QEIA---DLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ- 1563

Query: 443  GYRKDQEALEAVKRLKEK-LEAEMKKLNYEENKE--ESLLEKRRQLSRDIGRLKETYEAL 499
                 Q   E  +++ EK  E E  K NY+   E  +S L+   +   +  RLK+  E  
Sbjct: 1564 -LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGD 1622

Query: 500  LARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVT 559
            L     ++ ++       NR   + L   L SV+     T L L           D  + 
Sbjct: 1623 LNEI-EIQLSHA------NRQAAETL-KHLRSVQGQLKDTQLHL-----------DDALR 1663

Query: 560  GKKLLER--GELKRRYTIIPLNKISARCIAPETLR---VAQNLVGPDNVHVAL------S 608
            G++ L+     ++RR  ++       R    +T R   +A+  +   N  V L      S
Sbjct: 1664 GQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTS 1723

Query: 609  LVEYKPEL-----QKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTL 663
            L+  K +L     Q   E    +    +  + AKK   D  +M   +    D       +
Sbjct: 1724 LIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1783

Query: 664  SGGARSQAASILTKFQE-----LKDVQDELRIKENELRALEEELAG--LKNT-----AEK 711
                      +  +  E     LK  + +++  E  +R LE EL G   KNT       K
Sbjct: 1784 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRK 1843

Query: 712  YRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEE 771
            Y +  ++   ++EE D       Q    K Q ++ + K+  EE++E         RKA+ 
Sbjct: 1844 YERRVKELTYQSEE-DRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQH 1902

Query: 772  KYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQE 818
            + E         EAE   ++ ++Q     AKT+   SS+ +  + +E
Sbjct: 1903 ELE---------EAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 139/735 (18%), Positives = 292/735 (39%), Gaps = 68/735 (9%)

Query: 388  SSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD 447
            S+  +   AT+  +    K++++K++ + K+ + KL    QE  + Q +V+         
Sbjct: 843  SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902

Query: 448  QEALEAVKRLKEKLEAEMKKLNYEENKEES----LLEKRRQLSRDIGRLKETYEALLARF 503
            +E  + + + K +LEA++K++      EE     L  K+R+L  +   LK+  + L    
Sbjct: 903  EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL---- 958

Query: 504  PNLRFAYKDPEKNWNRNCVKGLVASLISVKD-----TSATTALELVAGERLYNVVVDTEV 558
              L  A  + EK+   N VK L   L  + +     T    AL+    + L ++  + + 
Sbjct: 959  -ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDK 1017

Query: 559  TGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNV--HVALSLVEYKPEL 616
                   + +L+++   +  +    + +  +  R  + L G   +     L L   K +L
Sbjct: 1018 VNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQL 1077

Query: 617  Q---KAMEFVFGTTFVCDNMDNAKKVAFDKRI---MTRTVTLGGDVFDPHGTLSGGARSQ 670
                K  +F +         +    + F K+I     R   L  ++     T +     Q
Sbjct: 1078 DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK-TEKQ 1136

Query: 671  AASILTKFQELKDVQDEL-----------RIKENELRALEEEL--AGLKNTAEKYRQLKQ 717
             +    + +EL +  +E            + +E E   L  +L  A L++ A      K+
Sbjct: 1137 RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKK 1196

Query: 718  QWEMKTE---EADLLQTKLQQSSYHKQQE--ELDALKKTIEESEETLKNTKEIQRKAEEK 772
              +   E   + D LQ   Q+    K +   E+D L  ++E   ++  N ++I R  E+ 
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED- 1255

Query: 773  YEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE 832
             ++ E + KN E +R       QK     +T+A   S++++EK+  V  ++   +   ++
Sbjct: 1256 -QLSEARGKNEEIQRSLSELTTQKSR--LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQ 1312

Query: 833  HTSYKQQLEAVNE-------AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVIT-- 883
                K+QLE  N+       A++S     +++  +  + +E   + Q  ++K    +   
Sbjct: 1313 TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1372

Query: 884  ----AQDTVIKAKYAEVAKHK--EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKD 937
                  D + + +  E AK K  ++  DS+ +++ ++   +  ++  +    +V  ++ D
Sbjct: 1373 RTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVD 1432

Query: 938  YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEER 997
             +  N+      +    +D      K   +  Q   E   K  R+++     +    EE 
Sbjct: 1433 VERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEA 1492

Query: 998  YNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLA 1057
             + L   KR  +N + +I    E + +       +  +K  K         L  A+  LA
Sbjct: 1493 LDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL--EKSRKQIE------LEKADIQLA 1544

Query: 1058 PPEGQTVLDGLEFKV 1072
              E +  L+  E K+
Sbjct: 1545 LEEAEAALEHEEAKI 1559



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 57/259 (22%), Positives = 114/259 (44%), Gaps = 33/259 (12%)

Query: 780  MKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELE------ELKREH 833
            +K+AE E+E     A  K +  KTK + +  + K K+ E + +TL  E      +++ E 
Sbjct: 841  LKSAETEKEM----ATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAES 896

Query: 834  TSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKY 893
             +     E  ++ IK+ + Q+E    EV +  E   +   E+T +K  +  + + +K   
Sbjct: 897  ENLLDAEERCDQLIKA-KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955

Query: 894  AE----VAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFG 949
             +    +AK +++ + ++ K+K L   +S      ++  AK+++  K             
Sbjct: 956  DDLELTLAKVEKEKHATENKVKNLTEELS----GLDETIAKLTREKKAL----------- 1000

Query: 950  QPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVE 1009
                A+    ++ +    ++  L + K KL + V     ++  E + R  DL + KR +E
Sbjct: 1001 --QEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRV-DLERNKRKLE 1057

Query: 1010 NDKSKILTTIEDLDQKKNQ 1028
             D      +I DL+  K Q
Sbjct: 1058 GDLKLAQESILDLENDKQQ 1076


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  104 bits (260), Expect = 4e-22
 Identities = 182/875 (20%), Positives = 369/875 (42%), Gaps = 128/875 (14%)

Query: 183  KTIEKKEAKLKEIKTILEE--EITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
            K + K     KE+ T+ EE   I  T++K  E R   LE +K++  ++  + L +  Q  
Sbjct: 839  KPLLKSAETEKEMATMKEEFGRIKETLEK-SEARRKELE-EKMVSLLQEKNDLQLQVQ-- 894

Query: 241  LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
             AE   +  AEE     D++IK + +L   + K+K +N  +E+ E+  + E     R LE
Sbjct: 895  -AEQDNLNDAEE---RCDQLIKNKIQL---EAKVKEMNERLED-EEEMNAELTAKKRKLE 946

Query: 301  DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
            D  +E ++         D  +  LA  E ++   E  +   ++ +A  ++ + K+T    
Sbjct: 947  DECSELKK-------DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 999

Query: 361  ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
            ALQEA  +  + L   +   N++S      E   +            D+  +  + K+ +
Sbjct: 1000 ALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVD------------DLEGSLEQEKKVR 1047

Query: 421  MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
            M L+ A+          +K++   +  QE++  ++  K +LE ++KK  ++ N++ S +E
Sbjct: 1048 MDLERAK----------RKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIE 1097

Query: 481  K--------RRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISV 532
                     +++L  +  R++E  E L A     R A    EK          + S +S 
Sbjct: 1098 DEQVLALQLQKKLKENQARIEELEEELEAE----RTARAKVEK----------LRSDLSR 1143

Query: 533  KDTSATTALELVAGERLYNVVVDT--EVTGKKL---LERGELKRRYTIIPLNKISARCIA 587
            +    +  LE   G     + ++   E   +K+   LE   L+   T   L K  A  +A
Sbjct: 1144 ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVA 1203

Query: 588  PETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMT 647
                ++       DN    L  V+ K E +K+ EF      V  NM+   K   +   ++
Sbjct: 1204 ELGEQI-------DN----LQRVKQKLEKEKS-EFKLELDDVTSNMEQIIKAKANLEKVS 1251

Query: 648  RTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELA-GLK 706
            RT+    D  + +      A+       T+  +L+    EL  +  E  AL  +L  G  
Sbjct: 1252 RTLE---DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKL 1308

Query: 707  NTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQ 766
            +  ++   LK+Q E + +  + L   LQ + +     + D L++  EE  E     + + 
Sbjct: 1309 SYTQQMEDLKRQLEEEGKAKNALAHALQSARH-----DCDLLREQYEEETEAKAELQRVL 1363

Query: 767  RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLEL 826
             KA  +      K +    +R  EL++A+KKL          ++++++ ++ VEA+  + 
Sbjct: 1364 SKANSEVAQWRTKYETDAIQRTEELEEAKKKL----------AQRLQDAEEAVEAVNAKC 1413

Query: 827  EELKREHTSYKQQLEAV-------NEAIKSYESQIEVMAAEVAKNKESVNKAQEEV-TKQ 878
              L++     + ++E +       N A  + + +       +A+ K+   ++Q E+ + Q
Sbjct: 1414 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1473

Query: 879  KEVITAQDTVIKAK--YAEVAKH----KEQNNDSQLKIKELD----------HNISKHKR 922
            KE  +    + K K  Y E  +H    K +N + Q +I +L           H + K ++
Sbjct: 1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRK 1533

Query: 923  EAEDGAAKVSKMLKDYD--WINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLG 980
            + E    ++   L++ +    + E  +          K    ++  ++ +++++ K    
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQ 1593

Query: 981  RNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKI 1015
            R V+    ++  E   R N++++ K+ +E D +++
Sbjct: 1594 RVVDSLQTSLDAETRSR-NEVLRVKKKMEGDLNEM 1627



 Score =  102 bits (254), Expect = 2e-21
 Identities = 169/779 (21%), Positives = 337/779 (43%), Gaps = 125/779 (16%)

Query: 185  IEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQ----KVMREIEHLSRLYIAYQFL 240
            I K +A L+++   LE++      KL+E + S  ++     K+  E   L+R     + L
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL 1299

Query: 241  LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALN---HEIEELEKRKDKETGGILR 297
            +++ T+ + +   ++M+D   +L+EE    +    AL    H+ + L ++ ++ET     
Sbjct: 1300 ISQLTRGKLSYT-QQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEET----- 1353

Query: 298  SLEDALAEAQRVNTKSQSAFDLKKKNLACEESKR-KELEKNMVEDSKTLAAKEKEVKKIT 356
               +A AE QRV +K+ S     +     +  +R +ELE+   + ++ L   E+ V+ + 
Sbjct: 1354 ---EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN 1410

Query: 357  DGLHALQEASNK---DAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQ 413
                +L++  ++   + E L    +  NA +A L   +   +  LA           + +
Sbjct: 1411 AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA-----------EWK 1459

Query: 414  TEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNY--- 470
             + +++Q +L+ +Q+E ++   E+ K+ + Y +  E LE  KR  + L+ E+  L     
Sbjct: 1460 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1519

Query: 471  EENKEESLLEK-RRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASL 529
            E  K    LEK R+QL  +   L+   E   A   +        +  +N+  +K  +   
Sbjct: 1520 EGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQ--IKAEIERK 1577

Query: 530  ISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPE 589
            ++ KD       E+   +R +  VVD+  T      R                      E
Sbjct: 1578 LAEKDE------EMEQAKRNHQRVVDSLQTSLDAETRSR-------------------NE 1612

Query: 590  TLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRT 649
             LRV + + G  N          + E+Q               + +A ++A + +   ++
Sbjct: 1613 VLRVKKKMEGDLN----------EMEIQ---------------LSHANRMAAEAQKQVKS 1647

Query: 650  VTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTA 709
            +           +L    + Q    +    +LK+    +  + N L+A  EEL  +    
Sbjct: 1648 LQ----------SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1697

Query: 710  EKYRQLKQQWEMKTEEADLLQTKLQQSSYH---KQQEELDALKKTIEESEETLKNTKEIQ 766
            E+ R+L +Q  ++T E   L      S  +   K + +L  L+  +EE+ +  +N +E  
Sbjct: 1698 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKA 1757

Query: 767  RKAEEKYEVLENKMK-----NAEAER-----ERELKDAQKKLDCAKTKADASSKKMKEKQ 816
            +KA     ++  ++K     +A  ER     E+ +KD Q +LD A+  A    KK  +K 
Sbjct: 1758 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK- 1816

Query: 817  QEVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEV 875
              +EA   ELE EL+ E    K+  E+V    KS E +I+ +  +  ++K+++ + Q+ V
Sbjct: 1817 --LEARVRELEGELEAEQ---KRNAESVKGMRKS-ERRIKELTYQTEEDKKNLLRLQDLV 1870

Query: 876  TKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM 934
             K +         +KA   +  + +EQ N +  K +++ H + + +  A+   ++V+K+
Sbjct: 1871 DKLQ-------LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1922



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 189/953 (19%), Positives = 378/953 (39%), Gaps = 146/953 (15%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
            E K   L + K  LE+++      L++E+   ++ ++  R++E   +L      +  E+ 
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL-TQESIMDLEND 1074

Query: 246  KVRSAEELKEMQDKV--------------IKLQEELSENDKKIKALNHEIEE---LEKRK 288
            K++  E+LK+ +  +              ++LQ++L EN  +I+ L  E+E       + 
Sbjct: 1075 KLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKV 1134

Query: 289  DKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAK 348
            +K    + R LE+     +     +    ++ KK  A  +  R++LE+  ++   T AA 
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194

Query: 349  EKE----VKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLS------SNEDGAEATL 398
             K+    V ++ + +  LQ    K  +  +  +   + V++ +       +N +    TL
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254

Query: 399  AGQMMACKNDISKAQ-------TEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEAL 451
              Q    +  + +AQ       T+  + Q +     ++L+ K+A + ++  G     + +
Sbjct: 1255 EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQM 1314

Query: 452  EAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSR-DIGRLKETYEA---LLARFPNLR 507
            E +KR  E           EE K ++ L    Q +R D   L+E YE      A    + 
Sbjct: 1315 EDLKRQLE-----------EEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1363

Query: 508  FAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERG 567
                     W        +     +++     A      +RL +     E    K     
Sbjct: 1364 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLA------QRLQDAEEAVEAVNAKCSSLE 1417

Query: 568  ELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKP-------ELQKAM 620
            + K R      N+I    +  E    A   +     +    L E+K        EL+ + 
Sbjct: 1418 KTKHRLQ----NEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1473

Query: 621  EFVFGTTFVCDNMDNAKKVAFD--KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKF 678
            +     +     + NA + + +  +        L  ++ D    L  G ++         
Sbjct: 1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKN--------V 1525

Query: 679  QELKDVQDELRIKENELR-ALEEELAGLKNTAEK-------YRQLKQQWEMKTEEADLLQ 730
             EL+ V+ +L +++ EL+ ALEE  A L++   K       + Q+K + E K  E D   
Sbjct: 1526 HELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD--- 1582

Query: 731  TKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAE---AER 787
             +  + +    Q  +D+L+ +++    +      +++K E     +E ++ +A    AE 
Sbjct: 1583 -EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEA 1641

Query: 788  ERELKDAQKKLDCAKTKAD---ASSKKMKEK-----------QQEVEAITLELEELKREH 833
            ++++K  Q  L   + + D    ++  +KE            Q E+E +   +E+ +R  
Sbjct: 1642 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 1701

Query: 834  TSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQ-KEVITAQDTVIK-- 890
               +Q+L   +E ++   SQ   +  +  K +  + + Q EV +  +E   A++   K  
Sbjct: 1702 KLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAI 1761

Query: 891  ---AKYAEVAKHKEQNNDSQLK---------IKELDHNISKHKREAEDGAAKVSKMLK-- 936
               A  AE  K KEQ+  + L+         IK+L H + + ++ A  G  K  + L+  
Sbjct: 1762 TDAAMMAEELK-KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEAR 1820

Query: 937  --------DYDWINAERHLFGQPNSAYDFK--TNNPKEAGQRLQKLQEMKEKLGRNVNMR 986
                    + +       + G   S    K  T   +E  + L +LQ++ +KL   V   
Sbjct: 1821 VRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAY 1880

Query: 987  AMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNK 1039
                  EAEE+ N  + K R V++          +LD+ + +A +IA  +VNK
Sbjct: 1881 KRQA-EEAEEQANTNLSKFRKVQH----------ELDEAEERA-DIAESQVNK 1921



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 85/411 (20%), Positives = 177/411 (43%), Gaps = 77/411 (18%)

Query: 171  TRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHL 230
            T +++ K  A ++++E  E   +E K  L+EEI+   ++L E   +  E +KV +++E  
Sbjct: 1481 TELFKLKN-AYEESLEHLETFKRENKN-LQEEISDLTEQLGEGGKNVHELEKVRKQLE-- 1536

Query: 231  SRLYIAYQFLLAEDTKVRSAEE-----LKEMQDKVIKLQEELSENDKKI-KALNHEIEEL 284
                        E  +++SA E     L+  + K+++ Q E ++   +I + L  + EE+
Sbjct: 1537 -----------VEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM 1585

Query: 285  EKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKT 344
            E+ K        + + D+L  +    T+S++     KK +   E    E+E  +   ++ 
Sbjct: 1586 EQAKRNH-----QRVVDSLQTSLDAETRSRNEVLRVKKKM---EGDLNEMEIQLSHANRM 1637

Query: 345  LAAKEKEVKKITDGLHALQ-------EASNKDAEALAAAQQHFNAVSAGLSSNEDGAEAT 397
             A  +K+VK +   L   Q        A++   E +A  ++  N + A L       E T
Sbjct: 1638 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1697

Query: 398  ---------------------------LAGQMMACKNDISKAQTEAKQAQMKLKHAQQEL 430
                                       L  Q    ++D+++ Q+E ++A  + ++A+++ 
Sbjct: 1698 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKA 1757

Query: 431  KNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEK--RRQLSRD 488
            K    +   M    +K+Q+    ++R+K+ +E  +K L +  ++ E +  K  ++QL + 
Sbjct: 1758 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL 1817

Query: 489  IGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATT 539
              R++E    L            + E+  N   VKG+  S   +K+ +  T
Sbjct: 1818 EARVRELEGEL------------EAEQKRNAESVKGMRKSERRIKELTYQT 1856



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 92/446 (20%), Positives = 184/446 (41%), Gaps = 94/446 (21%)

Query: 127  VQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA------ 180
            + DL   +G    N H L    ++ K L ++  E+ S +EEA  +  +E  KI       
Sbjct: 1511 ISDLTEQLGEGGKNVHEL---EKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEF 1567

Query: 181  -----------AQKTIEKKEAK------LKEIKTILEEEITPTIQKLKEERSSYLEYQKV 223
                       A+K  E ++AK      +  ++T L+ E     + L+ ++    +  ++
Sbjct: 1568 NQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEM 1627

Query: 224  MREIEHLSRLYI-------AYQFLLAE-----DTKVRSAEELKE-----------MQDKV 260
              ++ H +R+         + Q LL +     D  VR+ ++LKE           +Q ++
Sbjct: 1628 EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAEL 1687

Query: 261  IKL--------------QEELSENDKKIKALNHEIEELEKRKDKETGGILR---SLEDAL 303
             +L              ++EL E  ++++ L+ +   L  +K K    + +    +E+A+
Sbjct: 1688 EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAV 1747

Query: 304  AEAQRVNTKSQSAFDLKKKNLACEESKRKE--------LEKNMVEDSKTLAAKEKEVKKI 355
             E +    K++ A  +    +  EE K+++        ++KNM +  K L  +  E ++I
Sbjct: 1748 QECRNAEEKAKKA--ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1805

Query: 356  T--DGLHALQ--EASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISK 411
                G   LQ  EA  ++ E    A+Q  NA S       +     L  Q    K ++ +
Sbjct: 1806 ALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR 1865

Query: 412  AQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYE 471
             Q    + Q+K+K  +++ +  + +     S +RK Q  L+  +   +  E+++ KL   
Sbjct: 1866 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL--- 1922

Query: 472  ENKEESLLEKRRQLSRDIGRLKETYE 497
                       R  SRDIG  ++ ++
Sbjct: 1923 -----------RAKSRDIGAKQKMHD 1937



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 66/293 (22%), Positives = 117/293 (39%), Gaps = 38/293 (12%)

Query: 149  RITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQ 208
            R   +L  +  E+ +++E+   +R     K+A Q+ IE  E        +L  + T  I 
Sbjct: 1678 RRNNLLQAELEELRAVVEQTERSR-----KLAEQELIETSERV-----QLLHSQNTSLIN 1727

Query: 209  KLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELS 268
            + K+  S   + Q  + E     R           D  +  AEELK+ QD    L+    
Sbjct: 1728 QKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKK 1786

Query: 269  ENDKKIKALNHEIEELE-------KRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKK 321
              ++ IK L H ++E E       K++ ++    +R LE  L   Q+ N +S        
Sbjct: 1787 NMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES-------V 1839

Query: 322  KNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFN 381
            K +   E + KEL     ED K L   +  V K+   + A +  + +  E        F 
Sbjct: 1840 KGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR 1899

Query: 382  AVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
             V   L   E+ A             DI+++Q    +A+ +   A+Q++ +++
Sbjct: 1900 KVQHELDEAEERA-------------DIAESQVNKLRAKSRDIGAKQKMHDEE 1939



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 32/133 (24%), Positives = 61/133 (45%), Gaps = 16/133 (12%)

Query: 892  KYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQP 951
            K AE  K      +   +IKE        ++E E+   K+  +L++ + +  +       
Sbjct: 843  KSAETEKEMATMKEEFGRIKETLEKSEARRKELEE---KMVSLLQEKNDLQLQ------- 892

Query: 952  NSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYN-DLMKKKRIVEN 1010
                  + +N  +A +R  +L  +K K+     ++ MN   E EE  N +L  KKR +E+
Sbjct: 893  ---VQAEQDNLNDAEERCDQL--IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED 947

Query: 1011 DKSKILTTIEDLD 1023
            + S++   I+DL+
Sbjct: 948  ECSELKKDIDDLE 960


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  103 bits (258), Expect = 7e-22
 Identities = 185/879 (21%), Positives = 378/879 (43%), Gaps = 141/879 (16%)

Query: 239  FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDK--ETGGIL 296
            F   ++   RS    KE+++K++ L +E ++   ++++    + + E+R +   ++  +L
Sbjct: 860  FERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILL 919

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNL--ACEESKRK-----------ELEKNMVED-- 341
             +    L E      +  S    KK+NL   C   KR            E EK+  E+  
Sbjct: 920  EAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKV 979

Query: 342  ---SKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNA---VSAGLSSNEDGAE 395
               S+ + A E+ + K+T    +LQEA  +  + L   +   N    ++A L    D  E
Sbjct: 980  KNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLE 1039

Query: 396  ATLAGQMMACKNDISKAQTE-------AKQAQMKLKHAQQE----LKNKQAEVKKMDSGY 444
             +L  Q    + D+ +A+ +       ++++ M L++ +Q+    LK K+ E+ ++ +  
Sbjct: 1040 GSLE-QEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKI 1098

Query: 445  RKDQ-EALEAVKRLKEKLEAEMKKLNYEENKEESL---LEKRR-QLSRDI----GRLKET 495
              +Q  +L+  K++KE L+A +++L  E   E +L   +EK+R  L+R++     RL+E 
Sbjct: 1099 DDEQVHSLQFQKKIKE-LQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEA 1157

Query: 496  YEALLARFPNLRFAYKDPEKNWNRNCVKGLV---ASLISVKDTSATTALELVAGERLYNV 552
              A  A+    +    + +K   R+  +  +   A+  +++   A +  EL  GE++ N+
Sbjct: 1158 SGATSAQIEMNKKREAEFQK-MRRDLEEATLQHEATAATLRKKQADSVAEL--GEQIDNL 1214

Query: 553  VVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEY 612
                 V  K   E+ ELK     +  N  +         R  +       V    S ++ 
Sbjct: 1215 ---QRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCR------TVEDQFSEIKA 1265

Query: 613  KPELQKAMEFVFGTTFVCD-NMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQA 671
            K E Q        T  + D NM  A       R+ T+   L   V +    +S   +S+ 
Sbjct: 1266 KDEQQ--------TQLIHDLNMQKA-------RLQTQNGELSHRVEEKESLISQLTKSKQ 1310

Query: 672  ASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQT 731
            A +  + +ELK      R  E E +A       L+++      L++Q+E + E    LQ 
Sbjct: 1311 A-LTQQLEELK------RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363

Query: 732  KLQQSSYH----KQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAER 787
             L +++      + + E DA+++T EE EE  K   +  ++AEE  E   +K  + E  +
Sbjct: 1364 ALSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQEAEENTETANSKCASLEKTK 1422

Query: 788  ER---ELKDAQKKLD-----CA----------------KTKADASSKKMKEKQQEVEAIT 823
            +R   E++D  + L+     CA                K K D S  +++  Q+E  +++
Sbjct: 1423 QRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLS 1482

Query: 824  LELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVIT 883
             EL +++  +     QLE +    K+ + +I  +  ++A+  +++ +A+    K K+++ 
Sbjct: 1483 TELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAE----KTKKLVE 1538

Query: 884  AQDTVIKAKYAEV---AKHKEQ------------NNDSQLKIKELDHNISKHKREAEDGA 928
             + + ++    EV    +H+E              ++   K+ E D  I + KR ++  A
Sbjct: 1539 QEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAA 1598

Query: 929  AKVSKML-----KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV 983
              +  +L        D +  ++ + G  N       ++ ++  +  + L+ ++ +L    
Sbjct: 1599 EALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQL---- 1654

Query: 984  NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDL 1022
               +   L +A     DL ++  IVE     +L  +E++
Sbjct: 1655 -KDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 195/982 (19%), Positives = 417/982 (42%), Gaps = 170/982 (17%)

Query: 152  KVLNMKPPEILSMIEEAAGTRMYEYKKI--AAQKTI------EKKEAKLKEIKTILEEEI 203
            KV N+   E ++ +EE       E K +  A Q+T+      E K   L +I   LE++ 
Sbjct: 978  KVKNLS--EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQT 1035

Query: 204  TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AEDTKVRSAEELKEMQDKVIK 262
                  L++E+    + ++  R++E    L ++ + ++  E+ K +  E+LK+ + ++ +
Sbjct: 1036 DDLEGSLEQEKKLRADLERAKRKLE--GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ 1093

Query: 263  LQEELSEND-------KKIKALNHEIEELEK----------RKDKETGGILRSLEDALAE 305
            LQ ++ +         KKIK L   IEELE+          + +K+   + R LE+    
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISER 1153

Query: 306  AQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEK-------EVKKITDG 358
             +  +  + +  ++ KK  A  +  R++LE+  ++   T A   K       E+ +  D 
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN 1213

Query: 359  LHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLA------GQMMACKNDISKA 412
            L  +++   K+   L        +    LS ++   E T         ++ A     ++ 
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273

Query: 413  QTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEE 472
              +    + +L+    EL ++  E + + S   K ++A      L ++LE E+K+   EE
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQA------LTQQLE-ELKRQMEEE 1326

Query: 473  NKEESLLEKRRQLSR-DIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLIS 531
             K ++ +    Q SR D   L+E YE        L+ A                VA   +
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSE---------VAQWRT 1377

Query: 532  VKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETL 591
              +T A    E            + E   KKL +R +     T       +++C + E  
Sbjct: 1378 KYETDAIQRTE------------ELEEAKKKLAQRLQEAEENT----ETANSKCASLE-- 1419

Query: 592  RVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVT 651
            +  Q L G               E++  M  +  +   C  +D  K+  FDK +      
Sbjct: 1420 KTKQRLQG---------------EVEDLMRDLERSHTACATLDK-KQRNFDKVLAEWKQK 1463

Query: 652  LGGDVFDPHGTLSGGARSQAASILTKFQELK----DVQDELRIKENELRALEEELAGL-- 705
            L     D        A+ ++ S+ T+  +++    +V D+L     E + L+EE++ L  
Sbjct: 1464 L-----DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTE 1518

Query: 706  ------KN--TAEKYRQLKQQ-------------WEMKTEEADLLQTKLQQSSYHKQQEE 744
                  KN   AEK ++L +Q               ++ EE+ +L+ +L+ S   + + E
Sbjct: 1519 QIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELS---QVKSE 1575

Query: 745  LDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKN------AEAERERELKDAQKKL 798
            LD  +K IE+ EE  +  +  QR AE    VL+ ++++       + + E +L + + +L
Sbjct: 1576 LD--RKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQL 1633

Query: 799  DCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMA 858
              +  +   + K ++  Q +++   L L++  R +   K+QL  V         ++E M 
Sbjct: 1634 GHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMK 1693

Query: 859  AEVAKNKESVNKAQEEV---TKQKEVITAQDT-VIKAK----------YAEVAKHKEQNN 904
              + + + +   +++E+   + + +++ +Q+T +I  K           AEV    +++ 
Sbjct: 1694 VALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESR 1753

Query: 905  DSQLKIKELDHN---ISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNN 961
            +++ K K+   +   +++  ++ +D +A + +M K+ +     + L  + + A       
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE--QTVKDLQHRLDEAEQLALKG 1811

Query: 962  PKEAGQRLQ-KLQEMKEKL------------GRNVNMRAMNVLT-EAEERYNDLMKKKRI 1007
             K+  Q+L+ +++E++ +L            G +   R +  +T +AEE + ++++ + +
Sbjct: 1812 GKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDL 1871

Query: 1008 VENDKSKILTTIEDLDQKKNQA 1029
            V+  ++K+ +     ++ + QA
Sbjct: 1872 VDKLQAKVKSYKRQAEEAEEQA 1893



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 152/768 (19%), Positives = 315/768 (41%), Gaps = 110/768 (14%)

Query: 304  AEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGL---- 359
            AEA++     +  F+  K+ LA  E++RKELE+ MV   +     + +V+  T+ L    
Sbjct: 847  AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906

Query: 360  ---------HALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDIS 410
                       L EA  K+       ++  N+       N +   ++L   +   +  ++
Sbjct: 907  ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLT 966

Query: 411  KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA----LEAVKRLKEKLEAEMK 466
            K + E    + K+K+  +E+   +  + K+    +  QEA    L+ ++  ++K+   +K
Sbjct: 967  KVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIK 1026

Query: 467  ---KLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
               KL  + +  E  LE+ ++L  D+ R K   E  L        +  D E +      K
Sbjct: 1027 INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE---SIMDLEND------K 1077

Query: 524  GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISA 583
              +   +  K+   +     +  E+++++    ++         EL+ R     + ++  
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIK--------ELQAR-----IEELEE 1124

Query: 584  RCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK 643
               A  TLR        D       L     E+ + +E   G T     M+  ++  F K
Sbjct: 1125 EIEAEHTLRAKIEKQRSD-------LARELEEISERLEEASGATSAQIEMNKKREAEFQK 1177

Query: 644  -RIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELR------ 696
             R      TL  +      TL        A +  +   L+ V+ +L  +++EL+      
Sbjct: 1178 MRRDLEEATLQHEA--TAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235

Query: 697  -----ALEEELAGLKNTA----EKYRQLKQQWEMKTE---EADLLQTKLQQSS---YHKQ 741
                 AL +  + ++ T     +++ ++K + E +T+   + ++ + +LQ  +    H+ 
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRV 1295

Query: 742  QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801
            +E+   + +  +  +   +  +E++R+ EE     E K KNA A     L+ ++   D  
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEELKRQMEE-----ETKAKNAMA---HALQSSRHDCDLL 1347

Query: 802  KTKADASSKKMKEKQQEVEAITLELEELKREH-TSYKQQLEAVNEAIKSYESQIEVMAAE 860
            + + +   +   E Q+ +     E+ + + ++ T   Q+ E + EA K    +++    E
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ----E 1403

Query: 861  VAKNKESVNK--AQEEVTKQK---EVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDH 915
              +N E+ N   A  E TKQ+   EV      + ++  A     K+Q N         D 
Sbjct: 1404 AEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN--------FDK 1455

Query: 916  NISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEM 975
             +++ K++ ++  A++    K+   ++ E  LF   N AY+   +  +   +  + LQE 
Sbjct: 1456 VLAEWKQKLDESQAELEAAQKESRSLSTE--LFKMRN-AYEEVVDQLETLRRENKNLQEE 1512

Query: 976  KEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
               L   +     N L EAE       K K++VE +KS +   +E+++
Sbjct: 1513 ISDLTEQIAETGKN-LQEAE-------KTKKLVEQEKSDLQVALEEVE 1552



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 177/832 (21%), Positives = 334/832 (40%), Gaps = 128/832 (15%)

Query: 177  KKIAAQKTIEKKEAK--------LKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE 228
            ++I A+ T+  K  K        L+EI   LEE    T  +++  +    E+QK+ R++E
Sbjct: 1124 EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLE 1183

Query: 229  HLSRLYIAYQFLLAE---DTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELE 285
              +  + A    L +   D+     E++  +Q    KL++E SE   +I  +   IE L 
Sbjct: 1184 EATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS 1243

Query: 286  KRKDKETGGILRSLEDALAEAQ-RVNTKSQSAFDL-------------------KKKNLA 325
            K K        R++ED  +E + +   ++Q   DL                   +K++L 
Sbjct: 1244 KSKSN-IERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLI 1302

Query: 326  CEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSA 385
             + +K K+     +E+ K    +E + K      HALQ +S  D + L    +      A
Sbjct: 1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAM--AHALQ-SSRHDCDLLREQYEEEQEAKA 1359

Query: 386  GLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNK------------ 433
             L      A + +A      + D  +   E ++A+ KL    QE +              
Sbjct: 1360 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLE 1419

Query: 434  ------QAEVKKMDSGYRKDQEA---LEAVKRLKEKLEAEMK-KLNYEENKEESLLEKRR 483
                  Q EV+ +     +   A   L+  +R  +K+ AE K KL+  + + E+  ++ R
Sbjct: 1420 KTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESR 1479

Query: 484  QLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWN----------RNCVKG-LVASLISV 532
             LS ++ +++  YE ++ +   LR   K+ ++  +          +N  +      L+  
Sbjct: 1480 SLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQ 1539

Query: 533  KDTSATTALELVAG----ERLYNVVVDTEVTG-KKLLERGELKRRYTIIPLNKISARCIA 587
            + +    ALE V G    E    + V  E++  K  L+R  +++   I  L + S R   
Sbjct: 1540 EKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAE 1599

Query: 588  P-------------ETLRVAQNLVGPDNV------HVALSLVEYKPELQKAMEFVFGTTF 628
                          + LR+ + + G  N       H    + E +  L+     +  +  
Sbjct: 1600 ALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL 1659

Query: 629  VCD-----NMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD 683
              D     N D  +++A  +R   R   L  ++ +    L    R++  S     QEL D
Sbjct: 1660 HLDDALRSNEDLKEQLAIVER---RNGLLLEELEEMKVALEQTERTRRLSE----QELLD 1712

Query: 684  VQDELRIKE-------NELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQS 736
              D +++         N  + LE ++A  +   E   Q  +  E K ++A +    +   
Sbjct: 1713 ASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA-ITDAAMMAE 1771

Query: 737  SYHKQQE---ELDALKKTIEESEETLKNT-KEIQRKAEEKYEVLENKMKNAEAERERELK 792
               K+Q+    L+ +KK +E++ + L++   E ++ A +  +    K++N   E E EL 
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELD 1831

Query: 793  DAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYES 852
              QK+   A   A    +K+KE       +T + EE  +     +  ++ +   +KSY+ 
Sbjct: 1832 VEQKRGAEALKGAHKYERKVKE-------MTYQAEEDHKNILRLQDLVDKLQAKVKSYKR 1884

Query: 853  QIEVMAAEVAKNKES----VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
            Q E  A E A  + S    V    EE  ++ ++  +Q   ++AK  +V   K
Sbjct: 1885 QAE-EAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQK 1935



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 127/673 (18%), Positives = 278/673 (41%), Gaps = 74/673 (10%)

Query: 388  SSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD 447
            S+  +   AT+       K ++++++   K+ + K+    QE  + Q +V+         
Sbjct: 846  SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905

Query: 448  QEALEAVKRLKEKLEAEMK----KLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARF 503
            +E  E + + K  LEA++K    +L  EE     L+ K+R L      LK   + L    
Sbjct: 906  EERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL---- 961

Query: 504  PNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL 563
              L     + EK+   N VK L   + ++++  +    E  + +  +   +D        
Sbjct: 962  -ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD------- 1013

Query: 564  LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPE--LQKAME 621
            L+  E K    +  L KI+A+ +  +T  +  +L     +   L   + K E  L+ + E
Sbjct: 1014 LQVEEDK----VNGLIKINAK-LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE 1068

Query: 622  FVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQEL 681
             +        +++N K+   ++++  +   L          L      +    L   +++
Sbjct: 1069 SIM-------DLENDKQ-QIEEKLKKKEFEL--------SQLQAKIDDEQVHSLQFQKKI 1112

Query: 682  KDVQDELRIKENELRALEEELAGL-KNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHK 740
            K++Q  +   E E+ A     A + K  ++  R+L++  E   E +     +++ +   K
Sbjct: 1113 KELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNK--K 1170

Query: 741  QQEELDALKKTIEESEETLKNTKEIQRKAE-----EKYEVLENKMKNAEAERERELKDAQ 795
            ++ E   +++ +EE+    + T    RK +     E  E ++N ++  + + E+E  + +
Sbjct: 1171 REAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN-LQRVKQKLEKEKSELK 1229

Query: 796  KKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIE 855
             ++D   +  +A SK     ++    +  +  E+K +    +QQ + +++ +   +++++
Sbjct: 1230 MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD---EQQTQLIHD-LNMQKARLQ 1285

Query: 856  VMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDH 915
                E++   E       ++TK K+ +T Q   +K +  E  K K     + L+    D 
Sbjct: 1286 TQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHA-LQSSRHDC 1344

Query: 916  NISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEM 975
            ++ + + E E  A               +R L    +    ++T    +A QR ++L+E 
Sbjct: 1345 DLLREQYEEEQEAK-----------AELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1393

Query: 976  KEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDL--DQKKNQALNIA 1033
            K+KL +         L EAEE       K   +E  K ++   +EDL  D +++      
Sbjct: 1394 KKKLAQR--------LQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT 1445

Query: 1034 WQKVNKDFGSIFS 1046
              K  ++F  + +
Sbjct: 1446 LDKKQRNFDKVLA 1458



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 142/705 (20%), Positives = 280/705 (39%), Gaps = 73/705 (10%)

Query: 147  QGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEA--KLKEIKTILEEE-- 202
            Q ++   LNM+   + +   E +  R+ E + + +Q T  K+    +L+E+K  +EEE  
Sbjct: 1270 QTQLIHDLNMQKARLQTQNGELSH-RVEEKESLISQLTKSKQALTQQLEELKRQMEEETK 1328

Query: 203  ----ITPTIQKLKEE----RSSYLEYQKVMREIEHL---SRLYIAYQFLLAEDTKVRSAE 251
                +   +Q  + +    R  Y E Q+   E++     +   +A      E   ++  E
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388

Query: 252  ELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNT 311
            EL+E +    KL + L E ++  +  N +   LEK K +  G     +ED + + +R +T
Sbjct: 1389 ELEEAKK---KLAQRLQEAEENTETANSKCASLEKTKQRLQG----EVEDLMRDLERSHT 1441

Query: 312  KSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAE 371
             + +  D K++N    +    E ++ + E    L A +KE + ++  L  ++ A  +  +
Sbjct: 1442 -ACATLDKKQRNF---DKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497

Query: 372  ALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACK------NDISKAQTEAKQAQMKLKH 425
             L   ++    +   +S   +    T      A K       + S  Q   ++ +  L+H
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557

Query: 426  AQQELKNKQAEVKKMDSGY-RKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQ 484
             + ++   Q E+ ++ S   RK  E  E +++LK   +   + L       +S+L+   +
Sbjct: 1558 EESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEAL-------QSVLDAEIR 1610

Query: 485  LSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELV 544
               D  RLK+  E  L     ++  + + +    +  ++ +   L   KD+       L 
Sbjct: 1611 SRNDALRLKKKMEGDLNEM-EIQLGHSNRQMAETQKHLRTVQGQL---KDSQLHLDDALR 1666

Query: 545  AGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQ--NLVGPDN 602
            + E L   +   E     LLE  EL+     +   + + R    E L  +    L+   N
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLE--ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQN 1724

Query: 603  VHVALSLVEYKPELQKAMEFVFGTTFVCDNM-DNAKKVAFDKRIMTRTVTLGGDVFDPHG 661
              +  +  + + ++ +    V  +     N  + AKK   D  +M   +    D      
Sbjct: 1725 TSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784

Query: 662  TLSGGARSQAASILTKFQE-----LKDVQDELRIKENELRALEEEL-------AGLKNTA 709
             +          +  +  E     LK  + +++  EN +R LE EL       A     A
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGA 1844

Query: 710  EKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKA 769
             KY +  ++   + EE D       Q    K Q ++ + K+  EE+EE         R+ 
Sbjct: 1845 HKYERKVKEMTYQAEE-DHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRV 1903

Query: 770  EEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKE 814
            + + E         EA    ++ ++Q     AK++ D  S+KM+E
Sbjct: 1904 QHELE---------EAAERADIAESQVNKLRAKSR-DVGSQKMEE 1938



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 72/334 (21%), Positives = 140/334 (41%), Gaps = 33/334 (9%)

Query: 703  AGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNT 762
            AGL    E+ R  K    M + +A + +  L +  + K  E  D++   I+ +  +  N 
Sbjct: 771  AGLLGLLEEMRDEKLVTLMTSTQA-VCRGYLMRVEFKKMMERRDSIF-CIQYNIRSFMNV 828

Query: 763  KEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAI 822
            K         +  ++  +K+AEAE+E     A  K D  +TK + +  + + K+ E + +
Sbjct: 829  KHWPWM--NLFFKIKPLLKSAEAEKEM----ATMKEDFERTKEELARSEARRKELEEKMV 882

Query: 823  TLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVI 882
            +L L+E        + + E + +A +  E  I+      AK KE   + +EE     E++
Sbjct: 883  SL-LQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELV 941

Query: 883  TAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDH-------NISKHKREAEDGAAKVSKML 935
             A+   ++ K + + +  +    +  K+++  H       N+S+     E+  +K++K  
Sbjct: 942  -AKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK 1000

Query: 936  KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRL-QKLQEMKEKLGRNVNMRAMNVLTEA 994
            K      A +          D K N   +   +L Q+  +++  L +   +RA       
Sbjct: 1001 KSLQ--EAHQQTLDDLQVEED-KVNGLIKINAKLEQQTDDLEGSLEQEKKLRA------- 1050

Query: 995  EERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQ 1028
                 DL + KR +E D      +I DL+  K Q
Sbjct: 1051 -----DLERAKRKLEGDLKMSQESIMDLENDKQQ 1079


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  103 bits (258), Expect = 7e-22
 Identities = 215/1005 (21%), Positives = 421/1005 (41%), Gaps = 142/1005 (14%)

Query: 78   SVSITFDNSDKKQSPL-GFEVHDEITVTRQVVIG---GRNKYLINGVNANNTRVQDLFCS 133
            +V++  D  ++ ++ L   + H E   T +  I     RN ++      N    +D F  
Sbjct: 955  TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHM----EENTGETKDEFQQ 1010

Query: 134  VGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLK 193
              + ++    L  +   T   ++K  EI   IE+         +K   Q+ +E   A+ +
Sbjct: 1011 KMVGIDKKQDLEAKNTQTLTADVKDNEI---IEQQRKIFSLIQEKNELQQMLESVIAEKE 1067

Query: 194  EIKTILEEEITPTIQKLKEERSSYLEYQK----VMREIEH-------LSRLYIAYQFLLA 242
            ++KT L+E I  TI+  +E R    E +K    V +E  H       LSR     +    
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSR--TCDRLAEV 1125

Query: 243  EDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKR-KDKETGGILRSLE- 300
            E+     +++L+E Q +++ +QEE+SE  KKI    +EIE L+   K+KE    L  +E 
Sbjct: 1126 EEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI----NEIENLKNELKNKEL--TLEHMET 1179

Query: 301  DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
            + L  AQ++N   +       K++  E    KEL+K+   +   L    +E++    GL 
Sbjct: 1180 ERLELAQKLNENYEEV-----KSITKERKVLKELQKSFETERDHLRGYIREIE--ATGLQ 1232

Query: 361  ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
              +E        L  A  H       +           A   +    D+ K+ T+  Q +
Sbjct: 1233 TKEE--------LKIAHIHLKEHQETIDELRRSVSEKTA--QIINTQDLEKSHTKL-QEE 1281

Query: 421  MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEK---------LEAEMKKLNYE 471
            + + H +QEL     EV        + QE +  ++ L E+            EM++L   
Sbjct: 1282 IPVLHEEQELLPNVKEVS-------ETQETMNELELLTEQSTTKDSTTLARIEMERLRLN 1334

Query: 472  ENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLIS 531
            E  +ES  E+ + L+++   LK   EAL  +   L+   ++               +L  
Sbjct: 1335 EKFQES-QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRE---------------TLAK 1378

Query: 532  VKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETL 591
            ++++ +     L   E+      D E T K + E  + K      P +    R I  E L
Sbjct: 1379 IQESQSKQEQSLNMKEK------DNETT-KIVSEMEQFK------PKDSALLR-IEIEML 1424

Query: 592  RVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFG-TTFVCDNMDN--AKKVAFDKRIMTR 648
             +++ L   ++     S+ + K +LQ+  E +   +  + +N+    AK +  ++ +   
Sbjct: 1425 GLSKRL--QESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVA 1482

Query: 649  TVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEE--LAGLK 706
               L  +  +    L      +   I T  ++L+ + D+L+ K  E+   EE+  +  + 
Sbjct: 1483 HCCL-KEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQIS 1541

Query: 707  NTAEKYRQLKQQWEMKTEEADLLQT----------KLQQSSYH-----KQQEELDALKKT 751
               EK  +LKQ  E +  +   LQ+          +LQ+S        K++EE+  +++ 
Sbjct: 1542 EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA 1601

Query: 752  IEESEETLK-NTKEIQRKAEEKYE----------VLENKMKNAEAERERELKDAQK-KLD 799
            ++   + LK NTKEI  K +E  E          V E + K  E E  +E  + QK  L+
Sbjct: 1602 LQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE 1661

Query: 800  CAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIK-------SYES 852
              +T+    ++ + E  +E+ ++T E ++L+    + K + + + E ++         + 
Sbjct: 1662 NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQE 1721

Query: 853  QIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIK----AKYAEVAKHKEQNNDSQL 908
            +++++   + +++E+++K +  V+++   I+     ++    A  A+  K +E+   + +
Sbjct: 1722 ELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHM 1781

Query: 909  KIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQR 968
             +KE    I K +    +   K+S M KD +  NA+     Q   A + +    K+    
Sbjct: 1782 HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE 1841

Query: 969  LQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKS 1013
             QK     E+L + +  +++ +     E  N   K    +E  KS
Sbjct: 1842 TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS 1886



 Score =  102 bits (253), Expect = 3e-21
 Identities = 189/937 (20%), Positives = 401/937 (42%), Gaps = 116/937 (12%)

Query: 151  TKVLNMKPPEI-LSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQK 209
            TK+LN +  E  L+ +       + +Y+++  +K  E+ E KLKE   + E E      K
Sbjct: 488  TKLLNQENIESELNSLRADYDNLVLDYEQLRTEK--EEMELKLKEKNDLDEFEALERKTK 545

Query: 210  LKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEEL-S 268
              +E     E   +   ++H     +  Q L  E+      E L+E +D++ KLQE + S
Sbjct: 546  KDQEMQLIHEISNLKNLVKHAE---VYNQDL--ENELSSKVELLREKEDQIKKLQEYIDS 600

Query: 269  ENDKKIKA-LNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACE 327
            +  + IK  L++ +E +E  K  +     ++L DA  E   ++ K +SAF L+ +NL   
Sbjct: 601  QKLENIKMDLSYSLESIEDPKQMK-----QTLFDA--ETVALDAKRESAF-LRSENL--- 649

Query: 328  ESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGL 387
                 EL++ M E + T    E +++     L A ++      + L +A   FN ++  L
Sbjct: 650  -----ELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSA---FNEITK-L 700

Query: 388  SSNEDG-------AEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKM 440
            +S  DG           L G++   + +++K + E  +A  +      ELK+  +EV+++
Sbjct: 701  TSLIDGKVPKDLLCNLELEGKITDLQKELNK-EVEENEALREEVILLSELKSLPSEVERL 759

Query: 441  DSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALL 500
                +   E L  +   K+KL +E+    ++E++ + LLE+  +   D+   +  Y++  
Sbjct: 760  RKEIQDKSEELHIITSEKDKLFSEVV---HKESRVQGLLEEIGKTKDDLATTQSNYKSTD 816

Query: 501  ARFPNLRFAYKDPEKNW------NRNCVKGLV-ASLISVKDTSATTALELVAGERLYNVV 553
              F N +  + D E+ +      N    + +V  S  + K  S+  AL+     +   + 
Sbjct: 817  QEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ 876

Query: 554  VDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK 613
              T    ++L E  +LK +   +     + + +  E   + + L     +    +L + K
Sbjct: 877  EKTREVQERLNEMEQLKEQ---LENRDSTLQTVEREKTLITEKL--QQTLEEVKTLTQEK 931

Query: 614  PELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDP-HGTLSGGARSQAA 672
             +L++  E       +    D  K    D      TV +  D  +     L    + Q  
Sbjct: 932  DDLKQLQE------SLQIERDQLKSDIHD------TVNMNIDTQEQLRNALESLKQHQET 979

Query: 673  SILTKFQELKDVQDELRIKENELRALEE---ELAGLKNTAEKYRQLKQQWEMKTEEADLL 729
                K +  ++V   L ++EN     +E   ++ G+    +   +  Q      ++ +++
Sbjct: 980  INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039

Query: 730  QTKLQQSSYHKQQEELDALKKTI------------EESEETLKNTKEIQRKAEE--KYEV 775
            + + +  S  +++ EL  + +++            E  E T++N +E++   +E  K + 
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099

Query: 776  LENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTS 835
            +  + KN   ++E EL     +L   + K    S++++EKQQ++  +  E+ E++++   
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKK--- 1156

Query: 836  YKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEV---TKQKEVI--------TA 884
               ++E +   +K+ E  +E M  E  +  + +N+  EEV   TK+++V+        T 
Sbjct: 1157 -INEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETE 1215

Query: 885  QDTV---IKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKV---------- 931
            +D +   I+   A   + KE+   + + +KE    I + +R   +  A++          
Sbjct: 1216 RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSH 1275

Query: 932  SKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVL 991
            +K+ ++   ++ E+ L   PN     + +  +E    L+ L E           R     
Sbjct: 1276 TKLQEEIPVLHEEQELL--PNVK---EVSETQETMNELELLTEQSTTKDSTTLARIEMER 1330

Query: 992  TEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQ 1028
                E++ +  ++ + +  ++  + T  E L+ K +Q
Sbjct: 1331 LRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQ 1367



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 171/938 (18%), Positives = 396/938 (42%), Gaps = 155/938 (16%)

Query: 152  KVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTIL--EEEITPTIQK 209
            K+ ++   E    I+E   +   +  +I   + +EK   KL+E   +L  E+E+ P +++
Sbjct: 1238 KIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKE 1297

Query: 210  LKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSE 269
            + E        Q+ M E+E           LL E +  + +  L  ++ + ++L E+  E
Sbjct: 1298 VSET-------QETMNELE-----------LLTEQSTTKDSTTLARIEMERLRLNEKFQE 1339

Query: 270  NDKKIKALNHEIEELEKRKDK---ETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLAC 326
            + ++IK+L  E + L+  K+    +   +   + + LA+ Q   +K + + ++K+K+   
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKD--- 1396

Query: 327  EESKR--KELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVS 384
             E+ +   E+E+   +DS  L     E++ +  GL    + S+ + +++A  +     + 
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRI---EIEML--GLSKRLQESHDEMKSVAKEKDDLQRLQ 1451

Query: 385  AGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGY 444
              L S  D             K +I +   +  + + +LK A   LK ++  + ++    
Sbjct: 1452 EVLQSESD-----------QLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL 1500

Query: 445  RKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFP 504
             + +  +  +++   +LEA   KL   +NK + + EK  Q +  I ++ E  E +     
Sbjct: 1501 SEKETEISTIQK---QLEAINDKL---QNKIQEIYEKEEQFN--IKQISEVQEKV----- 1547

Query: 505  NLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLL 564
            N    +K+  K                 KD SA  ++E    E    +    E     + 
Sbjct: 1548 NELKQFKEHRK----------------AKD-SALQSIESKMLELTNRLQESQEEIQIMIK 1590

Query: 565  ERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVF 624
            E+ E+KR    + + +   +    E   VA+     +  +  L +       +K  E   
Sbjct: 1591 EKEEMKRVQEALQIERDQLKENTKEI--VAKMKESQEKEYQFLKMTAVNETQEKMCEIEH 1648

Query: 625  GTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDV 684
                      N + +  +   +T+ +         H  L      +  S+  +  +L+ V
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQIL---------HENLE-----EMRSVTKERDDLRSV 1694

Query: 685  QDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEE 744
            ++ L+++ ++L+        L+ T    R L++Q E+K     L +           QE 
Sbjct: 1695 EETLKVERDQLKE------NLRETIT--RDLEKQEELKIVHMHLKE----------HQET 1736

Query: 745  LDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLD----C 800
            +D L+  + E    + N ++    + +  +  + K++         LK+ Q+ +D     
Sbjct: 1737 IDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGI 1796

Query: 801  AKTKADA----------SSKKMKEKQQEVEA-----ITL------------ELEELKRE- 832
               K D           S+ K++EK QE++A     ITL            E+E+LK++ 
Sbjct: 1797 VSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQI 1856

Query: 833  ----HTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTV 888
                 T  K ++E +N A K +E+  E+ +  V K ++++ + +E +  +++ +      
Sbjct: 1857 KDQSLTLSKLEIENLNLAQKLHENLEEMKS--VMKERDNLRRVEETLKLERDQLKESLQE 1914

Query: 889  IKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLF 948
             KA+  E+   +++   +++  KE    + K + +  +   ++S + KD D    E    
Sbjct: 1915 TKARDLEI---QQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK 1971

Query: 949  GQPNSAYDFKTNNPKE----AGQRLQKLQEMKEKL-GRNVNMRAMNVLT-EAEERYNDLM 1002
             Q     + +    KE    + +++ +++++K++   +N++M+++ +   +  ++ ++ +
Sbjct: 1972 IQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESL 2031

Query: 1003 KKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKD 1040
            ++ RIV  ++ ++    E L  +++Q +    + + +D
Sbjct: 2032 EEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD 2069



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 175/901 (19%), Positives = 356/901 (39%), Gaps = 129/901 (14%)

Query: 183  KTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY--IAYQFL 240
            K  +K ++ L  +KT L  +     +K +E +    E +++  ++E+       +  +  
Sbjct: 852  KEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKT 911

Query: 241  LAEDTKVRSAEELKEM---QDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILR 297
            L  +   ++ EE+K +   +D + +LQE L     ++K+  H+   +     ++    L 
Sbjct: 912  LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971

Query: 298  SLEDALAEAQRVNTKSQSAFDLKKKNLACEESK---RKELEKNMVEDSKTLAAKEKEVKK 354
            SL+      + +NT      +   +NL  EE+    + E ++ MV   K    + K  + 
Sbjct: 972  SLKQ---HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQT 1028

Query: 355  ITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQT 414
            +T        A  KD E +   ++ F+ +    +  +   E+ +A +    K D+ +   
Sbjct: 1029 LT--------ADVKDNEIIEQQRKIFSLIQEK-NELQQMLESVIA-EKEQLKTDLKENIE 1078

Query: 415  EAKQAQMKLKHAQQELKNKQAEV-KKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEEN 473
               + Q +L+    ELK +Q  V ++ +   +K+ E      RL E  E   +K    + 
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138

Query: 474  KEESLLEKRRQLSRDIGRLKETYEALLARFPN--LRFAYKDPEK-------NWNRNCVKG 524
            K++ LL  + ++S    ++ E  E L     N  L   + + E+       N N   VK 
Sbjct: 1139 KQQQLLNVQEEMSEMQKKINEI-ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKS 1197

Query: 525  LVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISA- 583
            +      +K+   +   E    + L   + + E TG +  E  ELK  +  +  ++ +  
Sbjct: 1198 ITKERKVLKELQKSFETER---DHLRGYIREIEATGLQTKE--ELKIAHIHLKEHQETID 1252

Query: 584  ---RCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVA 640
               R ++ +T ++  N    +  H  L   E  P L +  E           + N K+V+
Sbjct: 1253 ELRRSVSEKTAQII-NTQDLEKSHTKLQ--EEIPVLHEEQEL----------LPNVKEVS 1299

Query: 641  FDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQE--------------LKDVQD 686
              +  M     L         T       +   +  KFQE              LK +++
Sbjct: 1300 ETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKE 1359

Query: 687  ELRIKENELRA-LEEELAGLKNTAEKYRQLKQQWEMKTEEADLL----QTKLQQSSYHKQ 741
             L +K ++L+  + E LA ++ +  K  Q     E   E   ++    Q K + S+  + 
Sbjct: 1360 ALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRI 1419

Query: 742  QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA----------EREREL 791
            + E+  L K ++ES + +K+  + +   +   EVL+++    +           E E EL
Sbjct: 1420 EIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEEL 1479

Query: 792  KDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYE 851
            K A   L   +   +     + EK+ E+  I              ++QLEA+N+ ++   
Sbjct: 1480 KVAHCCLKEQEETINELRVNLSEKETEISTI--------------QKQLEAINDKLQ--- 1522

Query: 852  SQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK 911
                             NK QE   K+++    Q + ++ K  E+ + KE        ++
Sbjct: 1523 -----------------NKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQ 1565

Query: 912  ELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRL-Q 970
             ++  + +     ++   ++  M+K       E+    +   A   + +  KE  + +  
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIK-------EKEEMKRVQEALQIERDQLKENTKEIVA 1618

Query: 971  KLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
            K++E +EK  + + M A+N   E +E+  ++   K   E  K   L  IE  + +  Q L
Sbjct: 1619 KMKESQEKEYQFLKMTAVN---ETQEKMCEIEHLKEQFETQKLN-LENIETENIRLTQIL 1674

Query: 1031 N 1031
            +
Sbjct: 1675 H 1675



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 171/814 (21%), Positives = 329/814 (40%), Gaps = 131/814 (16%)

Query: 262  KLQEELSENDKKIKALNH--EIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDL 319
            +L+ E  E + K+K  N   E E LE++  K+             E Q ++  S      
Sbjct: 516  QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ------------EMQLIHEISNL---- 559

Query: 320  KKKNLACE-ESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQ 378
              KNL    E   ++LE  +    + L  KE ++KK+ + + + Q+  N   +       
Sbjct: 560  --KNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS-QKLENIKMD------- 609

Query: 379  HFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEV- 437
                +S  L S ED        QM     D      +AK+    L+    ELK K  E+ 
Sbjct: 610  ----LSYSLESIEDPK------QMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELA 659

Query: 438  ---KKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKE 494
               K+M++  +  Q  LEA K+++  LE E++    E  K  SL++ +  + +D+     
Sbjct: 660  TTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGK--VPKDL----- 712

Query: 495  TYEALLARFPNLRFAYK--DPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNV 552
                      NL    K  D +K  N+            V++  A    E++    L ++
Sbjct: 713  --------LCNLELEGKITDLQKELNKE-----------VEENEALRE-EVILLSELKSL 752

Query: 553  VVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNL--VGPDNVHVALSLV 610
              + E   K++ ++ E     T    +K+ +  +  E+ RV   L  +G     +A +  
Sbjct: 753  PSEVERLRKEIQDKSEELHIITS-EKDKLFSEVVHKES-RVQGLLEEIGKTKDDLATTQS 810

Query: 611  EYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQ 670
             YK   Q+   F    T   D     K V  +   M + +           +  G  +++
Sbjct: 811  NYKSTDQEFQNF---KTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867

Query: 671  AASILTKFQELKDVQDELRIKENELRALEEELAGLKNT-----------AEKYRQLKQQW 719
             +    K QEL++   E++ + NE+  L+E+L    +T            EK +Q  ++ 
Sbjct: 868  LSY---KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924

Query: 720  EMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES-------EETLKNTKEIQRKAEEK 772
            +  T+E D L+ +LQ+S     Q E D LK  I ++       +E L+N  E  ++ +E 
Sbjct: 925  KTLTQEKDDLK-QLQESL----QIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979

Query: 773  YEVLENKMKNAEA------ERERELKDA-QKKLDCAKTKADASSKKMKE-----KQQEVE 820
               L++K+    +      E   E KD  Q+K+     K D  +K  +      K  E+ 
Sbjct: 980  INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039

Query: 821  AITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKE 880
                ++  L +E    +Q LE+V    +  ++ ++       +N+E +    +E+ KQ+E
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099

Query: 881  VITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDW 940
            ++  +      K  E+++  ++  + + K+KE    + + +++  +   ++S+M K  + 
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159

Query: 941  I-NAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYN 999
            I N +  L  +  +    +T       +RL+  Q++ E      N   +  +T+  +   
Sbjct: 1160 IENLKNELKNKELTLEHMET-------ERLELAQKLNE------NYEEVKSITKERKVLK 1206

Query: 1000 DLMKKKRIVENDKSKILTTIEDLDQKKNQALNIA 1033
            +L K      +     +  IE    +  + L IA
Sbjct: 1207 ELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 147/795 (18%), Positives = 326/795 (41%), Gaps = 91/795 (11%)

Query: 282  EELEKRKDKETGGILRSLEDALAEAQ-RVNTKSQSAFDLKKKNLA--CEESKRKELEKNM 338
            E L KR  KE   + + LE+   E + +   K Q A  L++K+L    +  K + L + +
Sbjct: 342  EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401

Query: 339  VEDSKTLAAKE---KEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNE---- 391
            V  S     +E   K  +++T  L  + +  N +         +    +  LS N     
Sbjct: 402  VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREI 461

Query: 392  DGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEAL 451
            D +  + +       + +S+ +       +  ++ + EL + +A+   +   Y       
Sbjct: 462  DESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDY------- 514

Query: 452  EAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYK 511
            E ++  KE++E ++K+ N  +  E   LE++ +  +++         L+    NL+   K
Sbjct: 515  EQLRTEKEEMELKLKEKN--DLDEFEALERKTKKDQEM--------QLIHEISNLKNLVK 564

Query: 512  DPEKNWNRNCVKGLVAS--LISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGEL 569
              E  +N++    L +   L+  K+       E +  ++L N+ +D   + + + +  ++
Sbjct: 565  HAEV-YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQM 623

Query: 570  KRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFV 629
            K+           A  +A +  R +  L   +     L L E   EL    + +     +
Sbjct: 624  KQTL-------FDAETVALDAKRESAFLRSEN-----LELKEKMKELATTYKQMENDIQL 671

Query: 630  CDNMDNAKK---VAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQD 686
              +   AKK   V  +K + +       ++      + G         L    ++ D+Q 
Sbjct: 672  YQSQLEAKKKMQVDLEKELQSAF----NEITKLTSLIDGKVPKDLLCNLELEGKITDLQK 727

Query: 687  ELRIKENELRALEEE---LAGLKNTAEKYRQLKQQWEMKTEEADLLQT---KLQQSSYHK 740
            EL  +  E  AL EE   L+ LK+   +  +L+++ + K+EE  ++ +   KL     HK
Sbjct: 728  ELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787

Query: 741  Q-------------QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAER 787
            +             +++L   +   + +++  +N K +    E+KY+++  + +    E 
Sbjct: 788  ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847

Query: 788  ERELKDAQK---KLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVN 844
                K+AQK    L   KT+    +++++EK +EV+    E+E+L       K+QLE  +
Sbjct: 848  VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL-------KEQLENRD 900

Query: 845  EAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNN 904
              +++ E +  ++  ++ +  E V    +E    K++  +         +++      N 
Sbjct: 901  STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960

Query: 905  DSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKE 964
            D+Q +++    ++ +H+       +K+S+           R+L  + N+         K 
Sbjct: 961  DTQEQLRNALESLKQHQETINTLKSKISE--------EVSRNLHMEENTGETKDEFQQKM 1012

Query: 965  AGQRLQKLQEMKEKLGRNVNMRAM-NVLTEAEERYNDLMKKKRIVENDKSKILTTIEDL- 1022
             G  + K Q+++ K  + +      N + E + +   L+++K  ++     ++   E L 
Sbjct: 1013 VG--IDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLK 1070

Query: 1023 -DQKKNQALNIAWQK 1036
             D K+N  + I  Q+
Sbjct: 1071 TDLKENIEMTIENQE 1085



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 178/956 (18%), Positives = 375/956 (39%), Gaps = 153/956 (16%)

Query: 149  RITKVLNMKPPEILSMIEEAAGTRMYEYK--------KIAAQKTIEKKEAKLKEIKTILE 200
            R+T++L+    E+ S+ +E    R  E          K   ++TI +   K +E+K +  
Sbjct: 1669 RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHM 1728

Query: 201  --EEITPTIQKLK---EERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKE 255
              +E   TI KL+    E+++  E   + +++EH +    A    + E+ ++     LKE
Sbjct: 1729 HLKEHQETIDKLRGIVSEKTN--EISNMQKDLEHSNDALKAQDLKIQEELRIAHMH-LKE 1785

Query: 256  MQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI------LRSLEDALAEAQRV 309
             Q+ + KL+  +SE   K+  +  ++E    +  ++   +      L +L+  + E Q+ 
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKK 1845

Query: 310  NTKSQ-------------SAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
             ++ +             S  +++  NLA +  +  E  K+++++   L   E+ +K   
Sbjct: 1846 VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER 1905

Query: 357  DGL-HALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTE 415
            D L  +LQE   +D E     QQ        LS         L  ++      IS  Q +
Sbjct: 1906 DQLKESLQETKARDLEI----QQELKTARM-LSKEHKETVDKLREKISEKTIQISDIQKD 1960

Query: 416  AKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKE 475
              +++ +L+   QEL+ K+ ++ ++        + +  +++LK++ EA+   +       
Sbjct: 1961 LDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSM------- 2013

Query: 476  ESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDT 535
            +S+     QL++   +L E+ E        +R   K+      R+ ++ +  SL   +D 
Sbjct: 2014 QSVRMDNFQLTK---KLHESLE-------EIRIVAKE------RDELRRIKESLKMERDQ 2057

Query: 536  SATTALELVAGERLYNVVVD------------TEVTGKKLLERGELKRRYTIIP-----L 578
               T  E++A +R  + V              TE   +K     EL +RY+ +      L
Sbjct: 2058 FIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECL 2117

Query: 579  NKIS------ARCIAPETLRVAQNLVGP------------DNVHVALSLVEYKPELQKAM 620
            N++S             ++RV  NL  P             N   ++       +L+  +
Sbjct: 2118 NRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVL 2177

Query: 621  EFVFG---------TTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQA 671
             +V             F  D +D  +K    K ++ +   L  D   P   L     +Q 
Sbjct: 2178 SYVTKIKEEQHESINKFEMDFIDEVEK---QKELLIKIQHLQQDCDVPSRELRDLKLNQN 2234

Query: 672  ASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQT 731
              +  + + LKD        E+E  +++ E   + +  ++  Q  ++W     + + L+ 
Sbjct: 2235 MDLHIE-EILKD------FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKN 2287

Query: 732  KLQQS----------------SYHKQQEELDALKKTI-EESEETLKNTKEIQRKAEEKYE 774
             +Q+                 +   +  E +    TI +E E+ LK+ KE   K  + Y+
Sbjct: 2288 GIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQ 2347

Query: 775  VLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHT 834
             L+  +  A   +        K           +++K++E +  +          + +  
Sbjct: 2348 TLKTSL--ASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII 2405

Query: 835  SYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYA 894
              +++LE  N+ I   ++++      + K KE++   Q++V    +    +   +K K  
Sbjct: 2406 KMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLV 2465

Query: 895  EVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSA 954
            ++   K +N       KE +  IS  K   E    +V ++L++    N  R    Q  S 
Sbjct: 2466 KIDLEKMKN------AKEFEKEISATKATVE-YQKEVIRLLRE----NLRRSQQAQDTSV 2514

Query: 955  YDFKT-----NNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKK 1005
                T     N P   G     +Q  K  + ++ ++R    +++ +++   L+K+K
Sbjct: 2515 ISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQK 2570



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 167/878 (19%), Positives = 362/878 (41%), Gaps = 142/878 (16%)

Query: 156  MKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERS 215
            +K  E +  ++EA      + K+   +   + KE++ KE + +    +  T +K+ E   
Sbjct: 1589 IKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEH 1648

Query: 216  SYLEYQKVMREIEHLSRLYIAYQFLLAEDTK-----------VRSAEELKEMQDKVIK-- 262
               +++     +E++    I    +L E+ +           +RS EE  +++   +K  
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKEN 1708

Query: 263  LQEELS---ENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDL 319
            L+E ++   E  +++K ++  ++E ++  DK   GI+    + ++  Q+    S  A  L
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDK-LRGIVSEKTNEISNMQKDLEHSNDA--L 1765

Query: 320  KKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQ-EASNKDAEALAAAQQ 378
            K ++L  +E  R     ++ E  +T+      V + TD L  +Q +  N +A+     Q+
Sbjct: 1766 KAQDLKIQEELR-IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824

Query: 379  HFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTE-AKQAQMKLKHAQQELKNKQAEV 437
                    L +NE         Q++  K D+++ Q + ++  Q+K +   Q L   + E+
Sbjct: 1825 --------LKANEH--------QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEI 1868

Query: 438  KKMDSGYRKDQEALEAVKRLKE-----------KLEAEMKKLNYEENKEESL-----LEK 481
            + ++   +  +   E    +KE           KLE +  K + +E K   L     L+ 
Sbjct: 1869 ENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKT 1928

Query: 482  RRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTAL 541
             R LS++    KET + L  +         D +K+ +++            KD       
Sbjct: 1929 ARMLSKE---HKETVDKLREKISEKTIQISDIQKDLDKS------------KDELQKKIQ 1973

Query: 542  ELVAGE-RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
            EL   E +L  V  D  ++ KK+ E  +LK+++       +S + +  +  ++ + L   
Sbjct: 1974 ELQKKELQLLRVKEDVNMSHKKINEMEQLKKQF---EAQNLSMQSVRMDNFQLTKKL--H 2028

Query: 601  DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
            +++     + + + EL++  E +         M+  + +A  + ++ R       V    
Sbjct: 2029 ESLEEIRIVAKERDELRRIKESL--------KMERDQFIATLREMIARD-RQNHQVKPEK 2079

Query: 661  GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
              LS G +    S+  K   +K++       ++    L      L+   E  ++L  + +
Sbjct: 2080 RLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVK 2139

Query: 721  -------MKTEEADLLQTKLQQSS--YHK---------------QQEELDALKK------ 750
                   ++T+  + L T  Q+ S  +H+               ++E+ +++ K      
Sbjct: 2140 ANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFI 2199

Query: 751  -TIEESEETLKNTKEIQRKAE-EKYEVLENKM-KNAEAERERELKD-AQKKLDCAKTKAD 806
              +E+ +E L   + +Q+  +    E+ + K+ +N +   E  LKD ++ +    KT+  
Sbjct: 2200 DEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQ 2259

Query: 807  ASSKKMKEKQQEVEA---ITLELEELKREHTSYKQQLEAVNE-------AIKSYESQIEV 856
                  KE  Q +E       ++E+LK        ++  VN        AI +  ++ E 
Sbjct: 2260 QVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEE 2319

Query: 857  MAAEVAKNKESVNKAQEEVTKQ--KEVITAQDTVIKAKYAEVAKHKEQNNDSQL------ 908
             +A ++K  E   K+ +E  ++  K   T + ++  A  A+V    + N +  +      
Sbjct: 2320 RSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSL--ASGAQVNPTTQDNKNPHVTSRATQ 2377

Query: 909  ----KIKELDHNISKHKREAEDGAAKVSKMLKDYDWIN 942
                KI+EL++++ + K  A    +K+ KM K+ +  N
Sbjct: 2378 LTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTN 2415



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 80/408 (19%), Positives = 169/408 (41%), Gaps = 63/408 (15%)

Query: 692  ENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEA-DLLQTKLQQSSYHKQQE-----EL 745
            E+EL +L  +   L    E+ R  K++ E+K +E  DL + +  +    K QE     E+
Sbjct: 497  ESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEI 556

Query: 746  DALKKTIEESE-------ETLKNTKEIQRKAEEKYEVLEN-----KMKNAEAERERELKD 793
              LK  ++ +E         L +  E+ R+ E++ + L+      K++N + +    L+ 
Sbjct: 557  SNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLES 616

Query: 794  AQKKLDCAKTKADASSKKMKEKQQE--VEAITLELEELKRE-HTSYKQQLEAVNEAIKSY 850
             +      +T  DA +  +  K++   + +  LEL+E  +E  T+YKQ    +   I+ Y
Sbjct: 617  IEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ----MENDIQLY 672

Query: 851  ESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQ-------DTVIKAKYAEVAK--HKE 901
            +SQ+E         ++ +  A  E+TK   +I  +       +  ++ K  ++ K  +KE
Sbjct: 673  QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKE 732

Query: 902  QNNDSQLK--------IKELDHNISKHKREAEDGAAKVSKMLKDYDWINAE--------- 944
               +  L+        +K L   + + ++E +D + ++  +  + D + +E         
Sbjct: 733  VEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQ 792

Query: 945  --RHLFGQPNSAYDFKTNNPKEAGQRLQKLQ------EMKEKL----GRNVNMRAMNVLT 992
                  G+         +N K   Q  Q  +      E K K+       +N   +N+  
Sbjct: 793  GLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK 852

Query: 993  EAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKD 1040
            EA++  + L   K  +     ++     ++ ++ N+   +  Q  N+D
Sbjct: 853  EAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 72/331 (21%), Positives = 133/331 (40%), Gaps = 49/331 (14%)

Query: 116  LINGVNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYE 175
            L NG+   N R+    C V    NN        RI  ++N       +  EE + T   E
Sbjct: 2285 LKNGIQKENDRI----CQVNNFFNN--------RIIAIMNES-----TEFEERSATISKE 2327

Query: 176  YKKIAAQKTIEKKEAKL----KEIKTILEE--EITPTIQKLKEERSSYLEYQKVMREIEH 229
            +++    K++++K  KL    + +KT L    ++ PT Q  K    +    Q    +I  
Sbjct: 2328 WEQDL--KSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRE 2385

Query: 230  LSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEK--R 287
            L            E++   + E     + K+IK+Q+EL   +  I  L  ++ E  K   
Sbjct: 2386 L------------ENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLE 2433

Query: 288  KDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKR-KELEKNMVEDSKTLA 346
            K KET   ++ L+D +A   +   +      +K   +  E+ K  KE EK +     T+ 
Sbjct: 2434 KTKET---IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVE 2490

Query: 347  AKEKEVKKITDGLHALQEASNKDAEALAAAQQHFN---AVSAGLSSNEDGAEATLAGQMM 403
             +++ ++ + + L   Q+A +    +     Q  N       G    ++     L  + +
Sbjct: 2491 YQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHI 2550

Query: 404  ACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
              + +ISK +   +Q +  +K   + L N Q
Sbjct: 2551 RLEKEISKLK---QQNEQLIKQKNELLSNNQ 2578


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  103 bits (258), Expect = 7e-22
 Identities = 180/850 (21%), Positives = 364/850 (42%), Gaps = 102/850 (12%)

Query: 154  LNMKPPEILSMIEEAAGTRMYEYKKIA-AQKTIEKKEAKLKEIKTILEEEITPTIQKLKE 212
            L  K  E+ + IEE       E    A A+K       +L+EI   LEE    T  +++ 
Sbjct: 1107 LQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVEL 1166

Query: 213  ERSSYLEYQKVMREIEHLSRLYIAYQFLLAE---DTKVRSAEELKEMQDKVIKLQEELSE 269
             +    E+QK+ R++E  +  + A    L +   D+     E++  +Q    KL++E SE
Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226

Query: 270  NDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEES 329
               +   L+   E + K K      + RSLED ++E +    + Q   +      A  ++
Sbjct: 1227 LKMETDDLSSNAEAISKAKGN-LEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQT 1285

Query: 330  KRKELEKNMVED----SKTLAAKEKEVKKITDGLHALQE---ASNKDAEALAAAQQHFNA 382
            +  E  + + E     S+   +K+   ++I +  H L+E   A N  A AL +++   + 
Sbjct: 1286 EAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDL 1345

Query: 383  VSAGLSSNEDGAEATLAGQMMACKNDIS----KAQTEAKQAQMKLKHAQQELKNKQAEVK 438
            +       ++G +A L   +    ++++    K +T+A Q   +L+ A+++L  +  E +
Sbjct: 1346 LREQYEEEQEG-KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1404

Query: 439  KMDSGYRKDQEALEAVK-RLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYE 497
            +          +LE  K RL+ ++E  M  +        +L +K+R   + +   K+ YE
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE 1464

Query: 498  ALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTE 557
               A    L  + K+          + L   L  VK+    + L+ +   R  N  +  E
Sbjct: 1465 ETQAE---LEASQKES---------RSLSTELFKVKNVYEES-LDQLETLRRENKNLQQE 1511

Query: 558  VTG--KKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDN---VHVALSLVEY 612
            ++   +++ E G+       I       +C     L  A+  +  +    + + L L + 
Sbjct: 1512 ISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQV 1571

Query: 613  KPELQKAM--------EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLG------GDVFD 658
            K E+ + +        +     T V + M +      D  I +R   L       GD+ +
Sbjct: 1572 KSEVDRKIAEKDEEIDQLKRNHTRVVETMQST----LDAEIRSRNDALRVKKKMEGDLNE 1627

Query: 659  PHGTLSGGARSQAASI--------LTKFQEL---------KDVQDELRIKENELRALEEE 701
                L+   R  A S+        + K  +L         +D++++L I E     L+ E
Sbjct: 1628 MEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAE 1687

Query: 702  LAGLKNTAEKYRQLKQQWEMK----TEEADLLQTKLQQ--SSYHKQQEELDALKKTIEES 755
            +  L  T E+  + ++  E +    +E   LL T+     ++  K + ++  L+  +EE 
Sbjct: 1688 IEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEV 1747

Query: 756  EETLKNTKEIQRKAEEKYEVLENKMK-----NAEAER-----ERELKDAQKKLDCAKTKA 805
             +  +N +E  +KA     ++  ++K     +A  ER     E+ +KD Q +LD A+  A
Sbjct: 1748 IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1807

Query: 806  DASSKKMKEKQQEVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
                KK  +K   +EA   ELE E++ E    K+  EAV + ++ +E +++ +  +  ++
Sbjct: 1808 LKGGKKQIQK---LEARVRELEGEVENEQ---KRNAEAV-KGLRKHERRVKELTYQTEED 1860

Query: 865  KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREA 924
            +++V + Q+ V K +         +K+   +  + +EQ+N +  K ++L H + + +  A
Sbjct: 1861 RKNVLRLQDLVDKLQ-------AKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERA 1913

Query: 925  EDGAAKVSKM 934
            +   ++V+K+
Sbjct: 1914 DIAESQVNKL 1923



 Score =  100 bits (248), Expect = 1e-20
 Identities = 138/691 (19%), Positives = 284/691 (41%), Gaps = 110/691 (15%)

Query: 388  SSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD 447
            S+  +   AT+  +    K++++K++ + K+ + K+    +E  + Q +V+         
Sbjct: 845  SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904

Query: 448  QEALEAVKRLKEKLEAEMKKLNYEENKEE----SLLEKRRQLSRDIGRLKETYEALLARF 503
            +E  E + + K +LEA++K++     +EE     L  K+R+L  +   LK+  + L    
Sbjct: 905  EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDL---- 960

Query: 504  PNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVD---TEVTG 560
              L  A  + EK+   N VK L   +  + +T A  + E  A +  +   +D    E   
Sbjct: 961  -ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDK 1019

Query: 561  KKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAM 620
              +L + + K    +  L           +L   + L         + L   K +L+  +
Sbjct: 1020 VNILTKAKTKLEQQVDDLE---------GSLEQEKKL--------RMDLERAKRKLEGDL 1062

Query: 621  EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQE 680
            +    +T    +M+N K+   D+++  +                     + +++++K ++
Sbjct: 1063 KLAQESTM---DMENDKQ-QLDEKLEKK-------------------EFEISNLISKIED 1099

Query: 681  LKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHK 740
             + V+ +L+ K  EL+A  EEL                 E++ E A   + + Q+S   +
Sbjct: 1100 EQAVEIQLQKKIKELQARIEELGE---------------EIEAERASRAKAEKQRSDLSR 1144

Query: 741  QQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDC 800
               EL+ + + +EE+        E+ +K E +++ L   ++ A  + E  +   +KK   
Sbjct: 1145 ---ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKK--- 1198

Query: 801  AKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860
                AD S  ++ E+   ++ +  +LE+ K E       L +  EAI   +  +E M   
Sbjct: 1199 ---HAD-SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRS 1254

Query: 861  VAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNND--SQL---------K 909
            +      +   +EE  +    +TAQ   ++ +  E ++  ++ +   SQL         +
Sbjct: 1255 LEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQ 1314

Query: 910  IKELDHNISKHKREAEDGAAKVSKMLKDYDWI------------NAERHLFGQPNSAYDF 957
            I+EL H + +  +     A  +     D D +              +R L    +    +
Sbjct: 1315 IEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1374

Query: 958  KTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILT 1017
            +T    +A QR ++L+E K+KL +         L EAEE    +  K   +E  K ++  
Sbjct: 1375 RTKYETDAIQRTEELEEAKKKLAQR--------LQEAEEHVEAVNAKCASLEKTKQRLQN 1426

Query: 1018 TIED--LDQKKNQALNIAWQKVNKDFGSIFS 1046
             +ED  LD +++ A   A  K  ++F  + S
Sbjct: 1427 EVEDLMLDVERSNAACAALDKKQRNFDKVLS 1457



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 179/949 (18%), Positives = 390/949 (41%), Gaps = 113/949 (11%)

Query: 149  RITKVLNMKPPEILSMIEEAAG-----TRMYEYKKIAA---QKTIEKKEAK------LKE 194
            ++ K  +    ++ ++ EE AG      ++ + KK      Q+T++  +A+      L +
Sbjct: 966  KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTK 1025

Query: 195  IKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AEDTKVRSAEEL 253
             KT LE+++      L++E+   ++ ++  R++E    L +A +  +  E+ K +  E+L
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE--GDLKLAQESTMDMENDKQQLDEKL 1083

Query: 254  K----EMQDKVIKLQEELS---ENDKKIKALNHEIEELEK----------RKDKETGGIL 296
            +    E+ + + K+++E +   +  KKIK L   IEEL +          + +K+   + 
Sbjct: 1084 EKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLS 1143

Query: 297  RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEK------ 350
            R LE+     +     + +  +L KK  A  +  R++LE+  ++    +AA  K      
Sbjct: 1144 RELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSM 1203

Query: 351  -EVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDI 409
             E+ +  D L  +++   K+   L       ++ +  +S     A+  L     + ++ +
Sbjct: 1204 AELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK----AKGNLEKMCRSLEDQV 1259

Query: 410  SKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLN 469
            S+ +T+ ++ Q  +     +    Q E  +      +    +  + R K+    ++++L 
Sbjct: 1260 SELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELK 1319

Query: 470  Y---EENKEESLLEKRRQLSR-DIGRLKETYEALLARFPNLRFAYKDPEK---NWNRNCV 522
            +   EE K ++ L    Q SR D   L+E YE        L+ A          W     
Sbjct: 1320 HQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE 1379

Query: 523  KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
               +     +++     A  L   E     V     + +K  +R + +    ++ + + +
Sbjct: 1380 TDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSN 1439

Query: 583  ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD 642
            A C A   L   Q               E + EL+ + +     +     + N  + + D
Sbjct: 1440 AACAA---LDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLD 1496

Query: 643  --KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELR-ALE 699
              + +      L  ++ D    ++ G +        +  EL+ ++ ++  ++ E++ ALE
Sbjct: 1497 QLETLRRENKNLQQEISDLTEQIAEGGK--------QIHELEKIKKQVEQEKCEIQAALE 1548

Query: 700  EELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETL 759
            E  A L++   K  +++ +      E D            ++ EE+D LK+      ET+
Sbjct: 1549 EAEASLEHEEGKILRIQLELNQVKSEVD--------RKIAEKDEEIDQLKRNHTRVVETM 1600

Query: 760  KNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV 819
            ++T + + ++      ++ KM       E +L + + +L+ A   A  S +  +  Q  +
Sbjct: 1601 QSTLDAEIRSRNDALRVKKKM-------EGDLNEMEIQLNHANRLAAESLRNYRNTQGIL 1653

Query: 820  EAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEV---T 876
            +   L L++  R     K+QL  V       +++IE + A + + + S   A++E+   +
Sbjct: 1654 KETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDAS 1713

Query: 877  KQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLK------IKELDHNISKHKREAEDGAAK 930
            ++ +++  Q+T +        K K +N+ SQL+      I+E  +   K K+   D A  
Sbjct: 1714 ERVQLLHTQNTSLIN-----TKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMM 1768

Query: 931  VSKMLKDYDWI--------NAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRN 982
              ++ K+ D          N E+ +    +   + +    K   +++QKL+    +L   
Sbjct: 1769 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE 1828

Query: 983  V------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQK 1025
            V      N  A+  L + E R  +L  +    E D+  +L  ++DL  K
Sbjct: 1829 VENEQKRNAEAVKGLRKHERRVKELTYQ---TEEDRKNVL-RLQDLVDK 1873



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 156/816 (19%), Positives = 338/816 (41%), Gaps = 83/816 (10%)

Query: 238  QFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDK------E 291
            +F   +D   +S  + KE+++K++ L +E ++   ++++    + + E+R ++      +
Sbjct: 858  EFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQ 917

Query: 292  TGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL--ACEESKR--KELEKNMVEDSKTLAA 347
                ++ + +   E + +N +       KK+ L   C E K+   +LE  + +  K   A
Sbjct: 918  LEAKIKEVTERAEEEEEINAE----LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 973

Query: 348  KEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKN 407
             E +VK +T+ +  L E   K ++   A Q+        L + ED              N
Sbjct: 974  TENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKV------------N 1021

Query: 408  DISKAQTEAKQAQMKLKHAQQELKNKQAEV----KKMDSGYRKDQEALEAVKRLKEKLEA 463
             ++KA+T+ +Q    L+ + ++ K  + ++    +K++   +  QE+   ++  K++L+ 
Sbjct: 1022 ILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE 1081

Query: 464  EMKKLNYEENKEESLLEKRR----QLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNR 519
            +++K  +E +   S +E  +    QL + I  L+   E L       R +    EK    
Sbjct: 1082 KLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ-RS 1140

Query: 520  NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRRYTII 576
            +  + L      +++    T+ ++   ++        E   +KL   LE   L+    + 
Sbjct: 1141 DLSRELEEISERLEEAGGATSAQVELNKK-------REAEFQKLRRDLEEATLQHEAMVA 1193

Query: 577  PLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA 636
             L K  A  +A    ++       DN    L  V+ K E +K+ E    T  +  N +  
Sbjct: 1194 ALRKKHADSMAELGEQI-------DN----LQRVKQKLEKEKS-ELKMETDDLSSNAEAI 1241

Query: 637  KKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELR 696
             K   +   M R++    D      T     +     +  +   L+    E   + +E  
Sbjct: 1242 SKAKGNLEKMCRSLE---DQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKD 1298

Query: 697  ALEEELAGLKN-TAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES 755
            AL  +L+  K  + ++  +LK Q E +T+  + L   LQ S     + + D L++  EE 
Sbjct: 1299 ALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSS-----RHDCDLLREQYEEE 1353

Query: 756  EETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKAD--------- 806
            +E     +    KA  +      K +    +R  EL++A+KKL     +A+         
Sbjct: 1354 QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAK 1413

Query: 807  -ASSKKMKEK-QQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
             AS +K K++ Q EVE + L++E       +  ++    ++ +  ++ + E   AE+  +
Sbjct: 1414 CASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEAS 1473

Query: 865  KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKE---LDHNISKHK 921
            ++       E+ K K V       ++    E    +++ +D   +I E     H + K K
Sbjct: 1474 QKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIK 1533

Query: 922  REAEDGAAKVSKMLKDYD--WINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKL 979
            ++ E    ++   L++ +    + E  +          K+   ++  ++ +++ ++K   
Sbjct: 1534 KQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH 1593

Query: 980  GRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKI 1015
             R V      +  E   R ND ++ K+ +E D +++
Sbjct: 1594 TRVVETMQSTLDAEIRSR-NDALRVKKKMEGDLNEM 1628



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 185/939 (19%), Positives = 396/939 (42%), Gaps = 144/939 (15%)

Query: 189  EAKLKEIKTILEE------EITPTIQKLKEERSSY--------LEYQKVMREIEHLSR-- 232
            EAK+KE+    EE      E+T   +KL++E S          L   KV +E +H +   
Sbjct: 919  EAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE-KHATENK 977

Query: 233  -LYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKE 291
               +  +    ++T  + ++E K +Q+   +  ++L   + K+  L     +LE++ D +
Sbjct: 978  VKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVD-D 1036

Query: 292  TGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNM------------- 338
              G L   +    + +R   K +    L +++    E+ +++L++ +             
Sbjct: 1037 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISK 1096

Query: 339  VEDSKTLAAK-EKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS----NEDG 393
            +ED + +  + +K++K++   +  L E    +  + A A++  + +S  L       E+ 
Sbjct: 1097 IEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1156

Query: 394  AEATLA---------GQMMACKNDISKA--QTEAKQAQMKLKHA---------------- 426
              AT A          +    + D+ +A  Q EA  A ++ KHA                
Sbjct: 1157 GGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRV 1216

Query: 427  QQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEK----LEAEMKKLNYEENKEESLLE-- 480
            +Q+L+ +++E+K        + EA+   K   EK    LE ++ +L  +E +++ L+   
Sbjct: 1217 KQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDL 1276

Query: 481  --KRRQLSRDIG---RLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDT 535
              +R +L  + G   R  +  +AL+++            K  +   ++ L   L   ++T
Sbjct: 1277 TAQRARLQTEAGEYSRQLDEKDALVSQLSR--------SKQASTQQIEELKHQL--EEET 1326

Query: 536  SATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQ 595
             A  AL        ++  +  E   ++   + EL+R      L+K ++      T     
Sbjct: 1327 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR-----ALSKANSEVAQWRTKYETD 1381

Query: 596  NLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGD 655
             +   + +  A   +  +  LQ+A E V      C +++  K     +R+      L  D
Sbjct: 1382 AIQRTEELEEAKKKLAQR--LQEAEEHVEAVNAKCASLEKTK-----QRLQNEVEDLMLD 1434

Query: 656  VFDPHGTLSGGARSQA--ASILTKF-QELKDVQDELRIKENELRALEEELAGLKNTAEKY 712
            V   +   +   + Q     +L+++ Q+ ++ Q EL   + E R+L  EL  +KN  E  
Sbjct: 1435 VERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYE-- 1492

Query: 713  RQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEK 772
                       E  D L+T  +++     Q+E+  L + I E  + +   ++I+++ E++
Sbjct: 1493 -----------ESLDQLETLRRENK--NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQE 1539

Query: 773  YEVLENKMKNAEAERERE---LKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEEL 829
               ++  ++ AEA  E E   +   Q +L+  K++ D   +K+ EK +E+       ++L
Sbjct: 1540 KCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVD---RKIAEKDEEI-------DQL 1589

Query: 830  KREHTSYKQQLEAVNEA-IKSYESQIEV---MAAEVAKNKESVNKAQEEVTKQKEVITAQ 885
            KR HT   + +++  +A I+S    + V   M  ++ + +  +N A     +        
Sbjct: 1590 KRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNT 1649

Query: 886  DTVIKAK--YAEVAKHKEQNNDSQLKIKELDHNISKHKRE---AEDGAAKVSKMLKDYDW 940
              ++K    + + A   +++   QL I E   N+ + + E   A     + S+ + + + 
Sbjct: 1650 QGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQEL 1709

Query: 941  INAERH---LFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEER 997
            ++A      L  Q  S  + K     +  Q   +++E+ ++  RN   +A   +T+A   
Sbjct: 1710 LDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQE-SRNAEEKAKKAITDAAMM 1768

Query: 998  YNDLMKKKRI---VENDKSKILTTIEDLDQKKNQALNIA 1033
              +L K++     +E  K  +  T++DL  + ++A  +A
Sbjct: 1769 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1807



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 156/767 (20%), Positives = 310/767 (40%), Gaps = 108/767 (14%)

Query: 304  AEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQ 363
            AE ++     +  F   K  LA  E+KRKELE+ MV   K     + +V+   D L   +
Sbjct: 846  AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905

Query: 364  EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEAT-----LAGQMMACKNDISKAQTEAK 417
            E   +  +     +     V+      E+  AE T     L  +    K DI   +    
Sbjct: 906  ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 965

Query: 418  QAQMKLKHAQQELKNKQAEVKKMD---SGYRKDQEAL-EAVKRLKEKLEAEMKKLN---- 469
            + + +    + ++KN   E+  +D   +   K+++AL E  ++  + L+AE  K+N    
Sbjct: 966  KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTK 1025

Query: 470  ------YEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
                   + +  E  LE+ ++L  D+ R K   E       +L+ A    E   +    K
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG------DLKLA---QESTMDMENDK 1076

Query: 524  GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISA 583
              +   +  K+   +  +  +  E+   + +  ++         EL+ R     + ++  
Sbjct: 1077 QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIK--------ELQAR-----IEELGE 1123

Query: 584  RCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK 643
               A    R        D       L     E+ + +E   G T     ++  ++  F K
Sbjct: 1124 EIEAERASRAKAEKQRSD-------LSRELEEISERLEEAGGATSAQVELNKKREAEFQK 1176

Query: 644  -RIMTRTVTLGGDVF-----DPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRA 697
             R      TL  +         H         Q  ++    Q+L+  + EL+++ ++L +
Sbjct: 1177 LRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSS 1236

Query: 698  LEEELAGLKNTAEKY-RQLKQQ-WEMKTEE-----------ADLLQTKLQQSSYHKQQEE 744
              E ++  K   EK  R L+ Q  E+KT+E           A   + + +   Y +Q +E
Sbjct: 1237 NAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDE 1296

Query: 745  LDALKKTIEESEE-TLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKT 803
             DAL   +  S++ + +  +E++ + EE     E K KNA A     L+ ++   D  + 
Sbjct: 1297 KDALVSQLSRSKQASTQQIEELKHQLEE-----ETKAKNALA---HALQSSRHDCDLLRE 1348

Query: 804  KADASSKKMKEKQQEVEAITLELEELKREH-TSYKQQLEAVNEAIKSYESQIEVMAAEVA 862
            + +   +   E Q+ +     E+ + + ++ T   Q+ E + EA K    +++    E  
Sbjct: 1349 QYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ----EAE 1404

Query: 863  KNKESVNK--AQEEVTKQKEVITAQDTVI---KAKYAEVAKHKEQNNDSQLKIKELDHNI 917
            ++ E+VN   A  E TKQ+     +D ++   ++  A  A  K+Q N         D  +
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRN--------FDKVL 1456

Query: 918  SKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNP-KEAGQRLQKLQEMK 976
            S+ K++ E+  A++    K+   ++ E            FK  N  +E+  +L+ L+   
Sbjct: 1457 SEWKQKYEETQAELEASQKESRSLSTEL-----------FKVKNVYEESLDQLETLRREN 1505

Query: 977  EKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
            + L + ++      + E  ++ ++L K K+ VE +K +I   +E+ +
Sbjct: 1506 KNLQQEIS-DLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAE 1551



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 153/759 (20%), Positives = 319/759 (42%), Gaps = 118/759 (15%)

Query: 182  QKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSY-LEYQKVMREIEHLSRLYIAYQFL 240
            +K     E ++ E+KT  EEE    I  L  +R+    E  +  R+++    L    Q  
Sbjct: 1249 EKMCRSLEDQVSELKT-KEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDAL--VSQLS 1305

Query: 241  LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGG---ILR 297
             ++    +  EELK   ++  K +  L+     +++  H+ + L ++ ++E  G   + R
Sbjct: 1306 RSKQASTQQIEELKHQLEEETKAKNALAH---ALQSSRHDCDLLREQYEEEQEGKAELQR 1362

Query: 298  SLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRK------ELEKNMVEDSKTLAAKEKE 351
            +L  A +E  +  TK ++  D  ++    EE+K+K      E E+++   +   A+ EK 
Sbjct: 1363 ALSKANSEVAQWRTKYET--DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKT 1420

Query: 352  VKKITDGLHALQ---EASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKN- 407
             +++ + +  L    E SN    AL   Q++F+ V +      +  +A L       ++ 
Sbjct: 1421 KQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL 1480

Query: 408  --DISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEM 465
              ++ K +   +++  +L+  ++E KN Q E+  +     +  + +  ++++K+++E E 
Sbjct: 1481 STELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEK 1540

Query: 466  KKLNYEENKEESLLE----KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNW---N 518
             ++     + E+ LE    K  ++  ++ ++K   +  +A         KD E +    N
Sbjct: 1541 CEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE--------KDEEIDQLKRN 1592

Query: 519  RNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPL 578
               V   + S +  +  S   AL +                 KK +E G+L      I L
Sbjct: 1593 HTRVVETMQSTLDAEIRSRNDALRV-----------------KKKME-GDLNEME--IQL 1632

Query: 579  NKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKK 638
            N   A  +A E+LR  +N  G         L E +  L  A+             D  ++
Sbjct: 1633 NH--ANRLAAESLRNYRNTQG--------ILKETQLHLDDALR---------GQEDLKEQ 1673

Query: 639  VAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKE------ 692
            +A  +R   R   L  ++ +   TL    RS+  +     QEL D  + +++        
Sbjct: 1674 LAIVER---RANLLQAEIEELWATLEQTERSRKIAE----QELLDASERVQLLHTQNTSL 1726

Query: 693  -NELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQE---ELDAL 748
             N  + LE +++ L++  E+  Q  +  E K ++A +    +      K+Q+    L+ +
Sbjct: 1727 INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLERM 1785

Query: 749  KKTIEESEE------------TLKNTKEIQRKAEEKYEVLENKMKNAE---AERERELKD 793
            KK +E++ +             LK  K+  +K E +   LE +++N +   AE  + L+ 
Sbjct: 1786 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRK 1845

Query: 794  AQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQ 853
             ++++     + +   K +   Q  V+ +  +++       SYK+Q E   E   +  S+
Sbjct: 1846 HERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVK-------SYKRQAEEAEEQSNANLSK 1898

Query: 854  IEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAK 892
               +  E+ + +E  + A+ +V K +       T I A+
Sbjct: 1899 FRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 94/408 (23%), Positives = 174/408 (42%), Gaps = 75/408 (18%)

Query: 149  RITKVLNMKPPEILSMIEEAAGTRMYEYKKIAA-------------QKTIEKKEA--KLK 193
            +I K +  +  EI + +EEA  +  +E  KI               +K  EK E   +LK
Sbjct: 1531 KIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1590

Query: 194  EIKTILEEEITPTIQKLKEERSSYLEYQKVMR--------EIEHLSRL-------YIAYQ 238
               T + E +  T+      R+  L  +K M         ++ H +RL       Y   Q
Sbjct: 1591 RNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQ 1650

Query: 239  FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELE---KRKDKETGGI 295
             +L E T++   + L+  +D    L+E+L+  +++   L  EIEEL    ++ ++     
Sbjct: 1651 GILKE-TQLHLDDALRGQED----LKEQLAIVERRANLLQAEIEELWATLEQTERSRKIA 1705

Query: 296  LRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKI 355
             + L DA    Q ++T++ S  + KKK L  + S+ +   + ++++S+   A+EK  K I
Sbjct: 1706 EQELLDASERVQLLHTQNTSLINTKKK-LENDVSQLQSEVEEVIQESRN--AEEKAKKAI 1762

Query: 356  TDGLHALQEASNK-DAEA-LAAAQQHFNAVSAGLSSNEDGAEA-TLAG---QMMACKNDI 409
            TD     +E   + D  A L   +++       L    D AE   L G   Q+   +  +
Sbjct: 1763 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV 1822

Query: 410  SKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMK--K 467
             + + E +  Q +   A + L+  +  VK++     +D++ +  ++ L +KL+A++K  K
Sbjct: 1823 RELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYK 1882

Query: 468  LNYEENKE--------------------------ESLLEKRRQLSRDI 489
               EE +E                          ES + K R  SR++
Sbjct: 1883 RQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1930



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 60/251 (23%), Positives = 114/251 (45%), Gaps = 17/251 (6%)

Query: 780  MKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQ 839
            +K+AE E+E     A  K +  KTK + +  + K K+ E + +TL L+E        + +
Sbjct: 843  LKSAETEKEM----ATMKEEFQKTKDELAKSEAKRKELEEKMVTL-LKEKNDLQLQVQSE 897

Query: 840  LEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYA-EVAK 898
             +++ +A +  E  I+      AK KE   +A+EE     E I A+ T  K K   E ++
Sbjct: 898  ADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEE-----EEINAELTAKKRKLEDECSE 952

Query: 899  HKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFK 958
             K+  +D +L + +    + K K   E+    +++ +   D   A+     +       +
Sbjct: 953  LKKDIDDLELTLAK----VEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQ 1008

Query: 959  TNNPKEAGQ-RLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILT 1017
            T +  +A + ++  L + K KL + V+    ++  E + R  DL + KR +E D      
Sbjct: 1009 TLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRM-DLERAKRKLEGDLKLAQE 1067

Query: 1018 TIEDLDQKKNQ 1028
            +  D++  K Q
Sbjct: 1068 STMDMENDKQQ 1078



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 57/279 (20%), Positives = 113/279 (40%), Gaps = 31/279 (11%)

Query: 160  EILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEI---TPTIQKLKEERSS 216
            E L+++E  A     E +++ A  T+E+ E   K    I E+E+   +  +Q L  + +S
Sbjct: 1672 EQLAIVERRANLLQAEIEELWA--TLEQTERSRK----IAEQELLDASERVQLLHTQNTS 1725

Query: 217  YLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRS------------AEELKEMQDKVIKLQ 264
             +  +K +     +S+L    + ++ E                  AEELK+ QD    L+
Sbjct: 1726 LINTKKKLEN--DVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1783

Query: 265  EELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL 324
                  ++ +K L H ++E E+   K     ++ LE  + E +      Q       K L
Sbjct: 1784 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGL 1843

Query: 325  ACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVS 384
               E + KEL     ED K +   +  V K+   + + +  + +  E   A    F  + 
Sbjct: 1844 RKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQ 1903

Query: 385  AGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKL 423
              L   E+ A+          ++ ++K + ++++   K+
Sbjct: 1904 HELEEAEERAD--------IAESQVNKLRVKSREVHTKI 1934


>gi|118498368 kinectin 1 isoform c [Homo sapiens]
          Length = 1300

 Score =  103 bits (257), Expect = 1e-21
 Identities = 206/988 (20%), Positives = 426/988 (43%), Gaps = 132/988 (13%)

Query: 147  QGRITKVLNM--KPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEA-----KLKEIKTIL 199
            +G +T +++   +  ++L+ ++E A       K++  +   EK+ +     ++K+    L
Sbjct: 324  KGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTL 383

Query: 200  EEEITPTIQKL----KEERSSYLEYQKVMREIE----HLSRLYIAYQFLLAEDT---KVR 248
            E+E      K+    +E +   +++Q+V  ++E    HL +     +  ++  T   + +
Sbjct: 384  EKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESK 443

Query: 249  SAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQR 308
             + EL +++    +L  EL+E   K++      EE++K+  ++       L+  L EA+R
Sbjct: 444  QSAELNKLRQDYARLVNELTEKTGKLQQ-----EEVQKKNAEQAA---TQLKVQLQEAER 495

Query: 309  VNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK----KITDGLHALQE 364
               + QS     +K  A  E+ +++L+   V       AKE EV+    K+TD L + Q+
Sbjct: 496  RWEEVQSYI---RKRTAEHEAAQQDLQSKFV-------AKENEVQSLHSKLTDTLVSKQQ 545

Query: 365  ASNKDAEALAAAQQHFNAVSAGLSSNEDGAEAT--LAGQMMACKNDISKAQTEAKQAQMK 422
               +  + + + Q+  N   +     +D  E    L  Q+    + I+ AQT A     +
Sbjct: 546  LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA-AQTSASVLAEE 604

Query: 423  LKHAQQELKNKQAEVKKMDSGYRKD-----QEALEAVKRLKEKLEAEMKKLNYEENKEES 477
            L     E K+KQ +  +      +D     +E L+ ++ +   L+AE++KL    N++ +
Sbjct: 605  LHKVIAE-KDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAA 663

Query: 478  LLEKRRQLSRDI----GRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLIS-V 532
               +  ++ + +     +++   E L     N    +K    N     +K  V  L + V
Sbjct: 664  AAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI--LNDQNKALKSEVQKLQTLV 721

Query: 533  KDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLR 592
             +      +E +  E+      +   T ++LLE G ++       LN I  R       +
Sbjct: 722  SEQPNKDVVEQM--EKCIQEKDEKLKTVEELLETGLIQVATKEEELNAI--RTENSSLTK 777

Query: 593  VAQNLVGPDNVHVAL-SLVEYKPELQKAMEFVFGTTFVCDNMDNAK--KVAFDKRIMTRT 649
              Q+L    N  V+  SLVE   EL+K +    G     + +  A+  KVA  ++ +   
Sbjct: 778  EVQDLKAKQNDQVSFASLVE---ELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDL 834

Query: 650  VTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRA-LEEELAGLKNT 708
                  + +  G +    ++Q  SI +K QEL+++      + N ++A LEE+   L NT
Sbjct: 835  KQEIKALKEEIGNVQL-EKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANT 893

Query: 709  AEKYRQLKQQWE-MKTEEADLLQTKLQQSSYHKQQEELDALKKT-----------IEESE 756
             +  + L+++ E +K    ++ Q  L+++S   Q EEL+ + K            ++E E
Sbjct: 894  GKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERE 953

Query: 757  ETLKNTKEIQRKAEEKYEVLENKMKNAE--------------------AERERELKDAQK 796
              L +  ++ +  +++ ++ +++++  +                    +ERE+E+     
Sbjct: 954  SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWN 1013

Query: 797  KLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE---------HTSYKQQLEAVNEAI 847
            +LD  K   +   KK  E+QQ+VEA+ LE +E+ ++         + SY + L    +  
Sbjct: 1014 ELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKA 1073

Query: 848  K------SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVI----KAKYAEVA 897
            K      S   +++V+  ++ +  E     Q E  K K V+   + ++    ++   E  
Sbjct: 1074 KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEEN 1133

Query: 898  KHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAER-HLFGQPNSAYD 956
            K K + ++S   IK++  + +  ++E E    ++    KD + +  ER HL  +   A  
Sbjct: 1134 KWKVKVDESHKTIKQMQSSFTSSEQELE----RLRSENKDIENLRREREHLEMELEKAEM 1189

Query: 957  FKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKIL 1016
             ++    E  +   +L E   KL    N        E ++   DL K ++ +E  +SKI+
Sbjct: 1190 ERSTYVTEVRELKAQLNETLTKLRTEQN--------ERQKVAGDLHKAQQSLELIQSKIV 1241

Query: 1017 TTIEDLDQKKNQALNIAWQKVNKDFGSI 1044
                D    +N  ++   +   K+  S+
Sbjct: 1242 KAAGDTTVIENSDVSPETESSEKETMSV 1269



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 183/934 (19%), Positives = 393/934 (42%), Gaps = 114/934 (12%)

Query: 160  EILSMI--EEAAGTRMYEYKKIAAQKTIEKKEAKLKE----IKTIL--EEEITPTIQKLK 211
            E++ ++  ++  G +    KK+  +   E  E K K+    +KT++  E+E    +  LK
Sbjct: 250  EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309

Query: 212  EE---------RSSYLEYQKVMREIEHLSRLYIAY---------------QFLLAEDTKV 247
            E+         +SS  E   ++ +++   +L  A                Q ++ E  K 
Sbjct: 310  EKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTE--KE 367

Query: 248  RSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQ 307
            RS   +  M+D++  L++E +    KI     E ++++ +  +    +   +E  +A  +
Sbjct: 368  RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQ----VREQMEAEIAHLK 423

Query: 308  RVN-----TKSQSAFDLKKKNLACEESKRKELEKNMVE-DSKTLAAKEKEVKKITDGLHA 361
            + N       S +   L+ K  A     R++  + + E   KT   +++EV+K       
Sbjct: 424  QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKN----- 478

Query: 362  LQEASNKDAEALAAAQQHFNAVSAGL---SSNEDGAEATLAGQMMACKNDISKAQTEAKQ 418
             ++A+ +    L  A++ +  V + +   ++  + A+  L  + +A +N++    ++   
Sbjct: 479  AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTD 538

Query: 419  AQMKLKHAQQEL----KNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENK 474
              +  +  +Q L    +++Q  V K +S   + Q+ LE  + LK +++    ++  + + 
Sbjct: 539  TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 598

Query: 475  EESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRN-CVKGLVASLISVK 533
                 E  + ++    ++K+T ++L +    L    ++ +   N N  +K  V  L ++ 
Sbjct: 599  SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALA 658

Query: 534  DTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRV 593
            +  A  A EL   ++   V  D     ++ L+  E+  +     +     + +  E  ++
Sbjct: 659  NEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH-EISNKMEEFKILNDQNKALKSEVQKL 717

Query: 594  AQNLV----GPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRT 649
             Q LV      D V      ++ K E  K +E +  T  +      A K      I T  
Sbjct: 718  -QTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLI----QVATKEEELNAIRTEN 772

Query: 650  VTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEE----ELAGL 705
             +L  +V D         ++   S  +  +ELK V  E   K+ +++++EE    EL  +
Sbjct: 773  SSLTKEVQD-----LKAKQNDQVSFASLVEELKKVIHE---KDGKIKSVEELLEAELLKV 824

Query: 706  KNTAEKYRQLKQQWEMKTEEADLLQ----------TKLQ--QSSYHKQQEELDALKKTIE 753
             N  +  + LKQ+ +   EE   +Q          +K+Q  Q+    ++E+++ +K  +E
Sbjct: 825  ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884

Query: 754  ESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMK 813
            E E+ L NT +  +  +E+ E L+    + +   +  LK+A      + ++ +     +K
Sbjct: 885  EKEKDLANTGKWLQDLQEENESLK---AHVQEVAQHNLKEAS-----SASQFEELEIVLK 936

Query: 814  EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQE 873
            EK+ E++ +   L+E + + +S  Q L+ V +  K ++SQIE +  +  +   S     E
Sbjct: 937  EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSF-PPHE 995

Query: 874  EVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAK--- 930
            E+ K   VI+ ++  I   + E+   K+     + K  E    +   + EA++   K   
Sbjct: 996  ELLK---VISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFP 1052

Query: 931  ---VSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRA 987
               V   L   +W+    H F +        T+  +E      KL+E  E +   + +  
Sbjct: 1053 KVSVPSNLSYGEWL----HGFEKKAKECMAGTSGSEEVKVLEHKLKEADE-MHTLLQLEC 1107

Query: 988  MNVLTEAEERYNDLMKKKRIVENDKSKILTTIED 1021
                +   E    L K +R VE +++K    +++
Sbjct: 1108 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDE 1141


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  103 bits (256), Expect = 1e-21
 Identities = 197/915 (21%), Positives = 362/915 (39%), Gaps = 157/915 (17%)

Query: 142  HFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE--AKLKEIKTIL 199
            H L +Q  I + L+ K  E    + EA G R+ E ++++++K ++K++  A L+   + L
Sbjct: 408  HGLQLQSEINQ-LHSKLLETERQLGEAHG-RLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465

Query: 200  EEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDK 259
            EE++     K K   S+ L++Q    + +H        Q  L + T  +    L+E Q+ 
Sbjct: 466  EEQL-----KEKVTNSTELQHQLDKTKQQHQE------QQALQQSTTAK----LREAQND 510

Query: 260  VIKLQEELSENDKKIKALNHEIEELEKRKDKETGGIL-RSLEDALAEAQRVNTKSQSAFD 318
            + ++  ++ + D+KI+ L     E   +K KE   +L +  ED  A+ Q    ++     
Sbjct: 511  LEQVLRQIGDKDQKIQNL-----EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565

Query: 319  LKKKNLACEES-------------KRKELEKNM---VEDSKT-LAAKEKEVKKITDGLHA 361
            L++KN   +E                K+ ++N+   V++ K  L A +  V  +   ++ 
Sbjct: 566  LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625

Query: 362  LQEASNKDAEALAAAQQHFNAVSAGLSSNE---DGAEATLAGQMMACKNDISKAQTEAKQ 418
            L    N+  E ++       A +  L S E       A L   +   +N +   Q E  +
Sbjct: 626  LNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNK 685

Query: 419  AQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEE-----N 473
               +L     +L++KQ    +++S  ++ +E   ++++  E+LE ++KKL  +      +
Sbjct: 686  ITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS 745

Query: 474  KEESL--LEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLIS 531
            KE++L  L+++RQL+ D+                LR      +    +  V      L  
Sbjct: 746  KEQALQDLQQQRQLNTDL---------------ELRATELSKQLEMEKEIVSSTRLDLQK 790

Query: 532  VKDTSATTALELVAGERLYNVVV-DTEVTGKKL-LERGELKRRY--TIIPLNKISARCIA 587
              +   +   +L   E    ++  D E   ++  ++  EL  R   T+  L K+    + 
Sbjct: 791  KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK---ME 847

Query: 588  PETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMT 647
             E L    + V      V+ SL   K E +K  E   G   + D     K++    ++  
Sbjct: 848  KEALMTELSTVKDKLSKVSDSLKNSKSEFEK--ENQKGKAAILDLEKTCKELKHQLQVQM 905

Query: 648  RTVTLGGDVFDPHGTLSGGARSQAASILTKFQE-LKDVQDELRIKENELRALEEELAGLK 706
                               A  Q    L   QE L   Q+ L+  E E + L+  +  LK
Sbjct: 906  ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965

Query: 707  NTAEKYR--------QLKQQWEMKTEEADLLQTKLQQSS----------------YHKQQ 742
             ++E+ +        +LK     KTE  + LQ +L Q++                Y K Q
Sbjct: 966  QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ 1025

Query: 743  EELDALKKTIEESEETLKNTKEIQRKAEEKYE-------------------VLENKMKNA 783
            E    L+      E  L  T++  +  EEK                     + E K   A
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085

Query: 784  EAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITL-ELEELKREHTSYKQQLEA 842
              E++   K+ Q +  C   +     K +KEK+   E   L E+EE+K      ++++  
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK---CRQEKEITK 1142

Query: 843  VNEAIKSY--ESQIEVMAAEVAKN------------------------------KESVNK 870
            +NE +KS+  ES  E+   + AK                               K+ V K
Sbjct: 1143 LNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202

Query: 871  AQEEVTKQ-KEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
             +EE+ K+  E      + IK K   + KH+E      ++I  L+ N+   K+E +    
Sbjct: 1203 EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQR 1262

Query: 930  KVSKMLKDYDWINAE 944
            +VS++ K  D +  E
Sbjct: 1263 RVSELEKQTDDLRGE 1277



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 154/768 (20%), Positives = 324/768 (42%), Gaps = 82/768 (10%)

Query: 180  AAQKTIEKKEAKLKEIKTILEEEITPTIQ-----KLKEERSSYLEYQKVMREIE---HLS 231
            AAQ  +   E  + E+ + L E      Q     K K E     E  K  +  +   HL 
Sbjct: 611  AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD 670

Query: 232  RLYIAYQFLLAEDTKVRS-----AEELKEMQDKVIKLQEELSENDKKIKALNHEIEELE- 285
                A Q    E  K+ +       +L++ Q+   +L+  L E  +K  +L  + EELE 
Sbjct: 671  TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG 730

Query: 286  --KRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSK 343
              K+ + ++  +  S E AL + Q+   + Q   DL+ +  A E SK+ E+EK +V  ++
Sbjct: 731  QIKKLEADSLEVKASKEQALQDLQQ---QRQLNTDLELR--ATELSKQLEMEKEIVSSTR 785

Query: 344  TLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE---ATLAG 400
                   +++K ++ L ++++   K  E     +Q F  +S       +       T   
Sbjct: 786  L------DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839

Query: 401  QMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDS-GYRKDQEALEAVKRLKE 459
            ++   K +     TE    + KL      LKN ++E +K +  G     +  +  K LK 
Sbjct: 840  ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899

Query: 460  KLEAEMKKLNYEENKEESLLEKRRQLSRDIG-RLKETYEALLARFPNLRFAYKDPEKNWN 518
            +L+ +M+    E+ + +  LEK ++ S  +   L    E L+     L+   K+ ++   
Sbjct: 900  QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ--- 956

Query: 519  RNCVKGLVASLISVKDTSATTA--LELVAGERLYNVVVDTEVTGK-------KLLERGEL 569
                  L  ++  +K +S      +E + GE    V+  TE+  K          E    
Sbjct: 957  ------LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010

Query: 570  KRRYTIIPLNKISARCIAPETLRVAQN-LVGPDNVHVAL--SLVEYKPELQKAMEFVFGT 626
            K + +++  N   ++    ET +  Q+   G ++  +A    L   + +L  A E     
Sbjct: 1011 KEKISVLQNNYEKSQ----ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE----- 1061

Query: 627  TFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQD 686
                D + N  ++    +++    T          TL   +  +   +  + + L+D+Q 
Sbjct: 1062 ----DLISNRNQIGNQNKLIQELKTA-------KATLEQDSAKKEQQLQERCKALQDIQK 1110

Query: 687  ELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTE-EADLLQTKLQQSSYHKQQEEL 745
            E  +KE EL   + +LA ++    K RQ K+  ++  E ++  L++  + ++    ++ L
Sbjct: 1111 EKSLKEKELVNEKSKLAEIEEI--KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL 1168

Query: 746  DALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKA 805
               K  ++   ++LK   E +++ ++   +L++++K  E E ++E  + + KL     + 
Sbjct: 1169 IQQKLELQGKADSLKAAVEQEKRNQQ---ILKDQVKKEEEELKKEFIEKEAKLHSEIKEK 1225

Query: 806  DASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNK 865
            +   KK +E + +   +T+++  L     + K++ ++    +   E Q + +  E+A  +
Sbjct: 1226 EVGMKKHEENEAK---LTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282

Query: 866  ESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKEL 913
             +V   Q+E     E     +  I+    +V + + + +++   ++EL
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 167/877 (19%), Positives = 358/877 (40%), Gaps = 134/877 (15%)

Query: 185  IEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAED 244
            + +K   L E     E++ T   +K  EE  S    Q  + + + L    +  +   +E 
Sbjct: 300  LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ-KDLDCQQLQSRLSASET 358

Query: 245  TKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEEL-EKRKDKETGGILRSLEDAL 303
            +  R   EL E  +   KL+EELSE + K + L  E ++L ++R++KE  G+    E   
Sbjct: 359  SLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQ 418

Query: 304  AEAQRVNTKSQ--SAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHA 361
              ++ + T+ Q   A    K+       K  + E+ + +    L+  E+++K+       
Sbjct: 419  LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478

Query: 362  LQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQM 421
            LQ   +K        QQH    +   S+                         + ++AQ 
Sbjct: 479  LQHQLDK------TKQQHQEQQALQQSTT-----------------------AKLREAQN 509

Query: 422  KLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEK 481
             L+   +++ +K  +++ +++  +K +E +  +++ +E L A+++    E      L EK
Sbjct: 510  DLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569

Query: 482  RRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTAL 541
               L   + +L E       +  N   ++K  ++N + + V+   A L + +D       
Sbjct: 570  NHTLQEQVTQLTE-------KLKNQSESHKQAQENLH-DQVQEQKAHLRAAQD------- 614

Query: 542  ELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPD 601
                  R+ ++         +L E  E K     I +   +   ++ E  + AQ      
Sbjct: 615  ------RVLSLETSVNELNSQLNESKE-KVSQLDIQIKAKTELLLSAEAAKTAQ------ 661

Query: 602  NVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHG 661
                       + +LQ             +++D A+    DK+     +T   D      
Sbjct: 662  -----------RADLQ-------------NHLDTAQNALQDKQQELNKITTQLDQVTAKL 697

Query: 662  TLSGGARSQAASILTKFQE----LKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ 717
                   SQ  S L +++E    L+   +EL   E +++ LE +   +K + E+  Q  Q
Sbjct: 698  QDKQEHCSQLESHLKEYKEKYLSLEQKTEEL---EGQIKKLEADSLEVKASKEQALQDLQ 754

Query: 718  QWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
            Q      + +L  T+               L K +E  +E + +T+   +K  E  E ++
Sbjct: 755  QQRQLNTDLELRATE---------------LSKQLEMEKEIVSSTRLDLQKKSEALESIK 799

Query: 778  NKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
             K+   E E++   +D +      K + +  + +++    E++ + +E E L  E ++ K
Sbjct: 800  QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859

Query: 838  QQLEAVNEAIKSYESQIEVMAAEVAKNKESV---NKAQEEVTKQKEVITAQDTVIKAKYA 894
             +L  V++++K+ +S+ E    E  K K ++    K  +E+  Q +V   ++T+ + K  
Sbjct: 860  DKLSKVSDSLKNSKSEFE---KENQKGKAAILDLEKTCKELKHQLQV-QMENTLKEQKEL 915

Query: 895  EVAKHKEQNNDSQLKIK---------ELDHNISKHKREAEDGAAKVSKMLKDYDWINAE- 944
            + +  KE+    QLK++         +  + + ++++E +     ++++ +  +    + 
Sbjct: 916  KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975

Query: 945  RHLFGQPNSAYDFKTNNPKEAGQRL----QKLQEMKEKLG--RNVNMRAMNVLTEAEE-- 996
              L G+   A   KT    +  Q+L    Q+L   KEK+   +N   ++     + +   
Sbjct: 976  EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035

Query: 997  --RYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALN 1031
              R ++L+  ++ +++ + K+    EDL   +NQ  N
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 161/871 (18%), Positives = 340/871 (39%), Gaps = 116/871 (13%)

Query: 199  LEEEITP--TIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL--LAEDTKVRSAEELK 254
            L+   TP  T+    E  S      + M+ +     L+  Y+ +     D+       L 
Sbjct: 20   LDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLA 79

Query: 255  EMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETG----------------GILRS 298
              +D V  L++E+ +    +K      EEL+K  +K  G                  L+S
Sbjct: 80   LKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQS 139

Query: 299  LEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDG 358
            LE  L EAQ  N   +   DL ++  A   ++  +++    E+     A E++V ++T+ 
Sbjct: 140  LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEE 199

Query: 359  LHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQ 418
            L       NK+A  +   +               G E      +   K ++ + QT    
Sbjct: 200  L-------NKEATVIQDLKTEL--------LQRPGIE-----DVAVLKKELVQVQTLMDN 239

Query: 419  AQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVK----RLKEKLEAEMKKLNYEENK 474
              ++ +   ++LK+   E KK+ S Y   +  +  ++    +  +++   +++L   ++ 
Sbjct: 240  MTLERERESEKLKD---ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296

Query: 475  EESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKD 534
               L +K + L+ ++ + ++ Y  L  +      + K+ +   ++   K L    +  + 
Sbjct: 297  VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ---KDLDCQQLQSRL 353

Query: 535  TSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVA 594
            +++ T+L  +  E    +    E T K   E  E++ +Y  +       +    E  +  
Sbjct: 354  SASETSLHRIHVE----LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHG 409

Query: 595  QNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGG 654
              L    N  +   L+E + +L +A     G       + + K +  ++++    + L  
Sbjct: 410  LQLQSEIN-QLHSKLLETERQLGEA----HGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464

Query: 655  DVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEEL-AGLKNTAEKYR 713
                           Q    +T   EL+   D+ + +  E +AL++   A L+       
Sbjct: 465  ------------LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE 512

Query: 714  QLKQQWEMKTEEADLLQTKLQQSSYH-----KQQEELDALKKTIEESEETLKNTKEIQRK 768
            Q+ +Q   K ++   L+  LQ+S  +     K++E+L A  +  E     L   +E    
Sbjct: 513  QVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHT 572

Query: 769  AEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEE 828
             +E+   L  K+KN     ++  ++   ++   K    A+  ++   +  V  +  +L E
Sbjct: 573  LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632

Query: 829  LKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTV 888
             K + +    Q++A  E + S E+      A++  + ++   A ++  ++   IT Q   
Sbjct: 633  SKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ 692

Query: 889  IKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLF 948
            + AK  +  +H  Q    +  +KE        +++ E+   ++ K+  D   + A +   
Sbjct: 693  VTAKLQDKQEHCSQ---LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE-- 747

Query: 949  GQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIV 1008
                              Q LQ LQ+ ++            + T+ E R  +L K+   +
Sbjct: 748  ------------------QALQDLQQQRQ------------LNTDLELRATELSKQ---L 774

Query: 1009 ENDKSKILTTIEDLDQKKNQALNIAWQKVNK 1039
            E +K  + +T  DL QKK++AL    QK+ K
Sbjct: 775  EMEKEIVSSTRLDL-QKKSEALESIKQKLTK 804



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 178/914 (19%), Positives = 378/914 (41%), Gaps = 119/914 (13%)

Query: 192  LKEIKTILEEEITPTIQKLKEERSSYLEY--------QKVMREIEHLSRLYIAYQFLLAE 243
            +K++K + E++      ++ + +S Y E         QKV R  E L++     Q L  E
Sbjct: 154  IKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTE 213

Query: 244  DTKVRSAEELKEMQDKVIKLQEELS----ENDKKIKALNHEIEELEKR--KDKETGGILR 297
              +    E++  ++ +++++Q  +     E +++ + L  E ++L+ +    + T   LR
Sbjct: 214  LLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR 273

Query: 298  SL-----EDALAEAQRVNTKSQSAFDLKKKNLACEESK-RKELEKNMVEDSKTLAAKEKE 351
            S      ++     Q +     S  +L +KN    E+  +KE +   +E+     +  K 
Sbjct: 274  SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSK- 332

Query: 352  VKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISK 411
             K I   LH       +    L+A++   + +   LS      EAT        K ++S+
Sbjct: 333  -KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK---GEAT-----QKLKEELSE 383

Query: 412  AQTEAKQAQMKLKHAQQELKNK-------QAEVKKMDSGYRKDQEAL-EAVKRLKEKLEA 463
             +T+ +  + + K  QQ+ + K       Q+E+ ++ S   + +  L EA  RLKE+ + 
Sbjct: 384  VETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQL 443

Query: 464  EMKKLNYEENK-----------EESLLEK---RRQLSRDIGRLKETYEALLA----RFPN 505
              +KL  +E +           EE L EK     +L   + + K+ ++   A        
Sbjct: 444  SSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK 503

Query: 506  LRFAYKDPEKNWNR-----NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTE--- 557
            LR A  D E+   +       ++ L A L   K+  +    E    E LY  +   E   
Sbjct: 504  LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER---EDLYAKIQAGEGET 560

Query: 558  VTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQ 617
                +L E+    +        K+  +    E+ + AQ     +N+H  +   E K  L+
Sbjct: 561  AVLNQLQEKNHTLQEQVTQLTEKLKNQS---ESHKQAQ-----ENLHDQVQ--EQKAHLR 610

Query: 618  KAMEFVFGTTFVCDNM-----DNAKKVA-FDKRIMTRT-VTLGGDVFDP--HGTLSGGAR 668
             A + V       + +     ++ +KV+  D +I  +T + L  +         L     
Sbjct: 611  AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD 670

Query: 669  SQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADL 728
            +   ++  K QEL  +  +L     +L+  +E  + L++  ++Y++     E KTEE + 
Sbjct: 671  TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG 730

Query: 729  LQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERE 788
               KL+  S   +  +  AL    ++ ++  +   +++ +A E  + LE + +   + R 
Sbjct: 731  QIKKLEADSLEVKASKEQAL----QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR- 785

Query: 789  RELKDAQKKLDCAKTKADASSKKMKEKQ---QEVEAITLELEELKREHTSYKQQLEAVNE 845
                D QKK +  ++     +K+ +EKQ   Q+ E ++   +E K +H     +++    
Sbjct: 786  ---LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS---QETKIQHEELNNRIQTTVT 839

Query: 846  AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKH-KEQNN 904
             ++  + + E +  E++  K+ ++K  + +   K     ++   KA   ++ K  KE  +
Sbjct: 840  ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899

Query: 905  DSQLKI-------KELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDF 957
              Q+++       KEL  ++ K K  +     +++ M +    I A+  L          
Sbjct: 900  QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL--IQAQNTLKQNEKEEQQL 957

Query: 958  KTN------NPKEAGQRLQKLQ-EMKEKLGRNVNM--RAMNVLTEAEERYNDLMKKKRIV 1008
            + N      + ++  ++++ LQ E+K  + +   +  +    LT+A +      +K  ++
Sbjct: 958  QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017

Query: 1009 ENDKSKILTTIEDL 1022
            +N+  K   T + L
Sbjct: 1018 QNNYEKSQETFKQL 1031


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  103 bits (256), Expect = 1e-21
 Identities = 172/905 (19%), Positives = 375/905 (41%), Gaps = 130/905 (14%)

Query: 182  QKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY------QKVMREIEHLSRL-- 233
            Q+ I K+  +++ +KT+  E         ++  SS L+       +++  +++ L +L  
Sbjct: 1343 QEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS 1402

Query: 234  -------YIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELS----ENDKKIKALNHEIE 282
                   Y++ Q    E    +   E+ E +D +  L  +L     E+D++IK L  E+ 
Sbjct: 1403 KKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELC 1462

Query: 283  ELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELE------- 335
            E+ K+K +E G      E++ A+ Q++  K Q+A   +K+ L   +S ++EL        
Sbjct: 1463 EM-KQKPEEIG------EESRAK-QQIQRKLQAALISRKEALKENKSLQEELSLARGTIE 1514

Query: 336  ---KNMVEDSKTLAAKEKEVKKITDGLHALQEASNK----------DAEALAAAQQHFNA 382
               K++ +    ++A+ KE   +   L  LQE  +K          + ++L+++ +    
Sbjct: 1515 RLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL 1574

Query: 383  VSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDS 442
               GL+ +++     L  ++ + K   S    E+ + Q K K  Q+E +      + + +
Sbjct: 1575 ALEGLTEDKE----KLVKEIESLK---SSKIAESTEWQEKHKELQKEYEILLQSYENVSN 1627

Query: 443  GYRKDQEALEAVKRLKEKL-------EAEMKKLNYEENKEESLLEKRRQLSRDIGRLKET 495
               + Q  +EAV++ K++L       EA  K+   +  + E  +E+ ++  R   + K+ 
Sbjct: 1628 EAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQ 1687

Query: 496  YEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVD 555
                L    +   A   P  +  + C++ L++S  S+K             E L  V ++
Sbjct: 1688 KILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMK-------------EELERVKME 1734

Query: 556  TEVTGKK----LLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVE 611
             E   KK    + E+  L      +  ++I         L   +      NV        
Sbjct: 1735 YETLSKKFQSLMSEKDSLSEEVQDLK-HQIEGNVSKQANLEATEKHDNQTNV-------- 1785

Query: 612  YKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQA 671
                 ++  + + G T   D++  + +    + + +                   A+S  
Sbjct: 1786 ----TEEGTQSIPGETEEQDSLSMSTRPTCSESVPS-------------------AKSAN 1822

Query: 672  ASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQT 731
             ++   F    ++ + L+    ++  L+E +AGL+   +K ++  Q  E +     L Q 
Sbjct: 1823 PAVSKDFSSHDEINNYLQ----QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL-LSQI 1877

Query: 732  KLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAEREREL 791
              +       QEE+  +    ++ +E L    +++  AEE+ + LE ++ N  AE    +
Sbjct: 1878 STKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI 1937

Query: 792  KDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSY-----KQQLEAVNEA 846
             +  + +  A+ K +    +MK  ++ V  +  E ++L +E T       K+ LE +  A
Sbjct: 1938 GNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGA 1997

Query: 847  IK--SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKA-KYAEVAKHKEQN 903
             K    +S  + +   + + ++ V + Q++  + +E I+A +  +KA ++ +    K+  
Sbjct: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLE 2057

Query: 904  NDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPK 963
               +   + ++H   + K +AE  + KV   L D     A R L        + ++N   
Sbjct: 2058 ITKENLAQAVEH---RKKAQAELASFKV---LLDDTQSEAARVLADNLKLKKELQSNKES 2111

Query: 964  EAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
               Q  QK ++++ +L      + +      +E+ + L ++K  +E    +I  T+   D
Sbjct: 2112 VKSQMKQKDEDLERRL-EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKD 2170

Query: 1024 QKKNQ 1028
            ++  Q
Sbjct: 2171 KEVQQ 2175



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 191/975 (19%), Positives = 382/975 (39%), Gaps = 158/975 (16%)

Query: 163  SMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQK 222
            S++E  + +   E  K+A +   E KE  +KEI+++   +I  + +  ++ +    EY+ 
Sbjct: 1558 SLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEI 1617

Query: 223  VMREIEHLS----RLYIAYQFLLAEDT----KVRSAE-ELKEMQDKVIKLQEELSENDKK 273
            +++  E++S    R+    + +  E      K+RS E   KE + ++ + ++E+ E  +K
Sbjct: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEK 1677

Query: 274  I----KALNHEIEELEKRKDK---------------------ETGGILRSLEDALAEAQR 308
            +    K+   +I ELE+  D+                         +   LE    E + 
Sbjct: 1678 MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYET 1737

Query: 309  VNTKSQSAFDLK----------KKNLACEESKRKELEKNMVEDSKTLAAKE--KEVKKIT 356
            ++ K QS    K          K  +    SK+  LE     D++T   +E  + +   T
Sbjct: 1738 LSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGET 1797

Query: 357  DGLHALQEASNKD-AEALAAAQQHFNAVSAGLSSNE---------DGAEATLAGQMMACK 406
            +   +L  ++    +E++ +A+    AVS   SS++         D  +  +AG     +
Sbjct: 1798 EEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ 1857

Query: 407  NDISKAQT---EAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEA 463
             +   +QT   E      ++     ELK  Q EV KM+   ++ QE L  V +LKE  E 
Sbjct: 1858 KNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEE 1917

Query: 464  EMKKLNYEENKEESLLEKRRQLSRDIGRLKETY-------EALLARFPNLRFAYKDPEKN 516
            E      +++ EE L+ +  +L+  IG   +         E L +   NL+    + E+ 
Sbjct: 1918 E------KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE 1971

Query: 517  WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTII 576
              +     LV     V+       LE + G +            K+   +   K    ++
Sbjct: 1972 KQQ-----LVKEKTKVESEIRKEYLEKIQGAQ------------KEPGNKSHAKELQELL 2014

Query: 577  PLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA 636
               +   + +  + +R  + +   +    AL  V+   E QK +E       +   +++ 
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQ--TESQKDLEIT--KENLAQAVEHR 2070

Query: 637  KK----VAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKE 692
            KK    +A  K ++  T +    V   +  L    +S   S+ ++ ++ KD   E R+++
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ-KDEDLERRLEQ 2129

Query: 693  NELRALEEELAGLKNTAEKYRQLKQQ--------------WEMKTEEADLLQ-------- 730
             E + L+E+    KN  EK   L+++                 K +E   LQ        
Sbjct: 2130 AEEKHLKEK----KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185

Query: 731  -----TKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA 785
                 TK   S    +   +D  KK   +  + +++ +E  R  E+   VL+++++    
Sbjct: 2186 QLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSI 2245

Query: 786  ERERELK--------DAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
              E ELK        D Q     A+T+     K     Q E + +  +LEE +  + S +
Sbjct: 2246 HME-ELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQ 2304

Query: 838  QQLEAVNEAIKSYESQIEVMAAEVAKNKES-------VNKAQEEVTKQKEVITAQDTVIK 890
             +L  +   +KS + Q+  ++  + K KE        + + + ++   K      +T ++
Sbjct: 2305 NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ 2364

Query: 891  AKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQ 950
            A     ++  E+ N  + KI  L       K EA   A    +   D +    E  L  +
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISL----LSGKEEAIQVAIAELRQQHDKEIKELENLLSQE 2420

Query: 951  PNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVEN 1010
                   +  N K   +  Q ++ +K     N+  +A         + +  +K    ++N
Sbjct: 2421 EEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKA---------QLDSFVKSMSSLQN 2471

Query: 1011 DKSKILTTIEDLDQK 1025
            D+ +I+   + L+++
Sbjct: 2472 DRDRIVGDYQQLEER 2486



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 170/870 (19%), Positives = 365/870 (41%), Gaps = 109/870 (12%)

Query: 183  KTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY----QKVMREIEHLSRLYIAYQ 238
            K ++K  ++L+E K  L +E T    ++++E   YLE     QK      H   L    Q
Sbjct: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKE---YLEKIQGAQKEPGNKSHAKEL----Q 2011

Query: 239  FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKD--------- 289
             LL E       +E+K++Q   I+ QE++S  ++ +KAL  E  + E +KD         
Sbjct: 2012 ELLKE-----KQQEVKQLQKDCIRYQEKISALERTVKAL--EFVQTESQKDLEITKENLA 2064

Query: 290  ------KETGGILRS----LEDALAEAQRV---NTKSQSAFDLKKKNLACEESKRKELEK 336
                  K+    L S    L+D  +EA RV   N K +      K+++  +  ++ E  +
Sbjct: 2065 QAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124

Query: 337  NMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEA 396
              +E ++    KEK  K + + L AL+       E +   Q   N     +   ++  ++
Sbjct: 2125 RRLEQAEEKHLKEK--KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDS 2182

Query: 397  TLAG------QMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA 450
            T+         M + ++D  +   EAK+ + K   A Q  K ++  +K+ +    KDQ  
Sbjct: 2183 TVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQS-KEEEIRLKEDNCSVLKDQ-- 2239

Query: 451  LEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDI-GRLKETYEALLARFPNLRFA 509
            L  +    E+L+  + +L +++   ES  +   QL + +   L+   + LL++    R  
Sbjct: 2240 LRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHL 2299

Query: 510  YKDPEKNWNRNCVKGLVASLISVKD--TSATTALELVAGER--LYNVVVDTEV---TGKK 562
            Y       ++N +  L + L S+KD  T  + +LE    ++  L  ++   E      K 
Sbjct: 2300 YHS-----SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKF 2354

Query: 563  LLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK-----PELQ 617
              E+ E   + +    +++       E   ++      + + VA++ +  +      EL+
Sbjct: 2355 SYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE 2414

Query: 618  KAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTK 677
              +        V +  +N K V    ++M    T+  +       L    +S     ++ 
Sbjct: 2415 NLLSQEEEENIVLEE-ENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS-----MSS 2468

Query: 678  FQELKD--VQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQ 735
             Q  +D  V D  +++E  L  + E+   ++  A +  +LK++        D L +    
Sbjct: 2469 LQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS---- 2524

Query: 736  SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENK-MKNAEAERERELKDA 794
                 +  +LDA      E    +   K+ Q+K   + ++ +NK ++N  A+ E +LK++
Sbjct: 2525 -----ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKES 2579

Query: 795  QKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQI 854
            ++  +  +   +A  ++ ++  +E+E++ + + +L R+ T+ +++       +  Y +Q+
Sbjct: 2580 EEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE-----GTLGLYHAQL 2634

Query: 855  EVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD 914
            +V   EV +     + +Q+ + + +E +         K  E+       +  + ++K L 
Sbjct: 2635 KVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEI------EDKLKKELKHLH 2688

Query: 915  HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974
            H+    + E E    +V+++ +D   +  +  +  + N      T   +  G+ +  LQ 
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGL---TAQIQSFGRSMSSLQN 2745

Query: 975  MKEKLGRNVNMRAMNVLTEAEERYNDLMKK 1004
             ++         A   L E + +Y+  +K+
Sbjct: 2746 SRD--------HANEELDELKRKYDASLKE 2767



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 187/961 (19%), Positives = 380/961 (39%), Gaps = 140/961 (14%)

Query: 172  RMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL--------EYQKV 223
            +M ++ K   QK +E     L+E    L  E+ P     KE   + L        E ++V
Sbjct: 1677 KMRKFAKSKQQKILE-----LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731

Query: 224  MREIEHLSRLYIAYQFLLAE-DTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIE 282
              E E LS+    +Q L++E D+     ++LK   +  +  Q  L   +K     N   E
Sbjct: 1732 KMEYETLSK---KFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEE 1788

Query: 283  ELEK--RKDKETGGILRSLEDALAEA------------------QRVNTKSQSAFDLKKK 322
              +    + +E   +  S     +E+                    +N   Q    LK++
Sbjct: 1789 GTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKER 1848

Query: 323  NLACEESKRK--ELEKNMVEDSKTL----AAKEKEVKKITDGLHALQEASNKDAEALAAA 376
                EE K+K  E  + +  +  TL    + K+ E+K + + +  +   + +  E L+  
Sbjct: 1849 IAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRV 1908

Query: 377  QQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKN---- 432
             +    +       +D  E  L  Q+      I     +   AQ+K +  + E+KN    
Sbjct: 1909 TK----LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKC 1964

Query: 433  -KQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKK---LNYEENKEESLLEKR---RQL 485
              + E +K      K +   E  K   EK++   K+    ++ +  +E L EK+   +QL
Sbjct: 1965 VSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL 2024

Query: 486  SRDIGRLKETYEALLARFPNLRFAYKDPEKNW------------NRNCVKGLVASL-ISV 532
             +D  R +E   AL      L F   + +K+             +R   +  +AS  + +
Sbjct: 2025 QKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084

Query: 533  KDTSATTALELVAGERLYNVVVDTEVTGKKLLERGE--LKRRYTIIPLNKISARCIAPET 590
             DT +  A  L    +L   +   + + K  +++ +  L+RR        +  +    E 
Sbjct: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144

Query: 591  LRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA--KKVAFDKRIMTR 648
            L   +     + VH+  ++ E +  L K  + V     + +N+D+   +  AF K + + 
Sbjct: 2145 LDALRR----EKVHLEETIGEIQVTLNKKDKEV---QQLQENLDSTVTQLAAFTKSMSS- 2196

Query: 649  TVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNT 708
               L  D            R  + +I +K +E++  +D   + +++LR +   +  LK  
Sbjct: 2197 ---LQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKIN 2253

Query: 709  AEKYRQLKQQWEMKTEEADLLQTKL-----------------QQSSYHKQQEELDALKKT 751
              +    KQ WE K +    LQ K+                  +  YH  Q EL  L+  
Sbjct: 2254 ISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE 2313

Query: 752  IEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERER---ELKDAQKKLDCAKTKADAS 808
            ++  ++ L +      K +E+   LE  ++  EA+ +      +  +  L  ++      
Sbjct: 2314 LKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRL 2373

Query: 809  SKKMKEKQQEV--------EAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860
             +++  K+Q++        EAI + + EL+++H    ++L    E + S E +  ++  E
Sbjct: 2374 HEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKEL----ENLLSQEEEENIVLEE 2429

Query: 861  VAKNKESVNKAQEEV----TKQKEVITAQ---DTVIKAKYA-EVAKHKEQNNDSQLKIKE 912
              +NK++V+K  + +    T +KE I  +   D+ +K+  + +  + +   +  QL+ + 
Sbjct: 2430 --ENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487

Query: 913  LDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKE-------- 964
            L   + K +   ++ AA+ +K+ ++   + +        N+  D +    +E        
Sbjct: 2488 LSIILEKDQL-IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITI 2546

Query: 965  ---AGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIED 1021
                 ++L ++Q  + K   N   +    L E+EE   DL +    ++ +K  +   IE 
Sbjct: 2547 KDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIES 2606

Query: 1022 L 1022
            L
Sbjct: 2607 L 2607



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 146/746 (19%), Positives = 313/746 (41%), Gaps = 99/746 (13%)

Query: 146  MQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITP 205
            +Q ++   L  +  E+LS +EE     +Y     ++Q  + K E++LK +K  L + ++ 
Sbjct: 2274 LQQKVCDTLQGENKELLSQLEETR--HLYH----SSQNELAKLESELKSLKDQLTD-LSN 2326

Query: 206  TIQKLKEERSSYLEYQKVMREIE-HLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQ 264
            +++K KE++ +    + ++R+ E  +     +Y+ L   +T ++++ EL     + I ++
Sbjct: 2327 SLEKCKEQKGNL---EGIIRQQEADIQNSKFSYEQL---ETDLQASRELTSRLHEEINMK 2380

Query: 265  EE--LSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKK 322
            E+  +S    K +A+   I EL ++ DKE    ++ LE+ L++ +             ++
Sbjct: 2381 EQKIISLLSGKEEAIQVAIAELRQQHDKE----IKELENLLSQEE-------------EE 2423

Query: 323  NLACEESKRKELEKN--MVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHF 380
            N+  EE  +K ++K   ++E  KT+  +  + K   D       +   D + +    Q  
Sbjct: 2424 NIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483

Query: 381  NAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKM 440
                  +   +D                I +A  E  + + +++  +  + +  +E  K+
Sbjct: 2484 EERHLSIILEKDQL--------------IQEAAAENNKLKEEIRGLRSHMDDLNSENAKL 2529

Query: 441  DSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALL 500
            D+   + +E L  V  +K+  + ++ ++  ++NKE  L  K  +L   +   +E  E L 
Sbjct: 2530 DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE--LENKYAKLEEKLKESEEANEDLR 2587

Query: 501  ARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNV---VVDTE 557
              F  L+   +D  K      ++ L  S+  +  T   TAL+      LY+    V + E
Sbjct: 2588 RSFNALQEEKQDLSKE-----IESLKVSISQL--TRQVTALQEEGTLGLYHAQLKVKEEE 2640

Query: 558  VTGKKLLERGELKR----RYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK 613
            V     L     KR       ++ + K +A+ +     ++ + L    ++H    ++  +
Sbjct: 2641 VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKEL---KHLHHDAGIMRNE 2697

Query: 614  PELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAAS 673
             E  +          V +       V  + + +T  +   G            A  +   
Sbjct: 2698 TETAEERVAELARDLV-EMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDE 2756

Query: 674  ILTKFQ-ELKDVQD--ELRIKENELRALEEELAGLKNTAEK-----YRQLKQQWEMKTEE 725
            +  K+   LK++    E  +   E  AL  E A   N+ E+       +L QQ   K E+
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQ 2816

Query: 726  ADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEE-------------- 771
               L ++L+ S  + Q +       +++   + L N  E  RK+EE              
Sbjct: 2817 LLHLSSQLEDS--YNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPA 2874

Query: 772  KYEVLENKMKNAEAERER---ELKDAQK---KLDCAKTKADASSKKMKEKQQEVEAITLE 825
            + + L+  M + + +R+R   ELK+ Q+   +++   T+      +++E Q + +A  + 
Sbjct: 2875 EVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIM 2934

Query: 826  LEELKREHTSYKQQLEAVNEAIKSYE 851
             EEL++E+ S++ +L  +     S+E
Sbjct: 2935 QEELRQENLSWQHELHQLRMEKSSWE 2960



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 155/872 (17%), Positives = 350/872 (40%), Gaps = 126/872 (14%)

Query: 186  EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
            +K E  ++  +TI  +++   +Q+  +E S +L    +    +H +    ++  +  E T
Sbjct: 408  DKNEQAVQSAQTI--QQLEDQLQQKSKEISQFLNRLPLQ---QHETASQTSFPDVYNEGT 462

Query: 246  KVRSAEELKEMQDKVIKLQEELSENDKKIKALNH-EIEELEKRKDKETGGI-LRSLEDAL 303
            +  + E +  +Q +V++L     EN+K    L+  E+EEL+   +K +  I L   ++  
Sbjct: 463  QAVTEENIASLQKRVVEL-----ENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517

Query: 304  AEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQ 363
             EA R  ++        K++ + EES +  LE    +  K L+    E+K+  + +  L+
Sbjct: 518  GEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLK 577

Query: 364  -------------------EASNKDAEALAAAQQHFNAVSAG----LSSNEDGAEATLAG 400
                               E    + E +A  +        G    L  NE+ +   +  
Sbjct: 578  LQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEK 637

Query: 401  QMMACKNDI-SKAQTEAKQAQMKLKHAQQ------------------ELKNKQAEVKKMD 441
            +  + ++   +  +     A ++LK  +Q                  EL+  ++++ +++
Sbjct: 638  EQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697

Query: 442  SGYRKDQEALEA--------VKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLK 493
              + K QE  E         +  L + +E   K  +   +   +L E+R QL   +  L 
Sbjct: 698  LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELS 757

Query: 494  ETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVV 553
               E L A+   L     + E+                  D  + TA + +  E+++++ 
Sbjct: 758  MVTE-LRAQVKQLEMNLAEAERQRRL--------------DYESQTAHDNLLTEQIHSLS 802

Query: 554  VDTEVTGKKL-LERGELKRRYTIIPLNKISARCIAPETL-RVAQNLVGPDNV-HVALSLV 610
            ++ +    K+ + + EL              R +  +   + ++ L G + V H++  + 
Sbjct: 803  IEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862

Query: 611  EYKPEL-QKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVT-LGGDVFDPHGTLSGGAR 668
            E    L QK +E       + +   + + +        + VT +   + +    L+    
Sbjct: 863  ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922

Query: 669  SQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKY--------RQLKQQWE 720
            S    I T  ++L  +      K+ ++    E  +GLK   ++          +L+ +++
Sbjct: 923  SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982

Query: 721  MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
            +  +E +  + KLQ +  ++++     L + +   EE L N K+     E K E+  ++ 
Sbjct: 983  LLKKENEQRKRKLQAALINRKE-----LLQRVSRLEEELANLKD-----ESKKEIPLSET 1032

Query: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMK----EKQQEVEAITLELEELKREHTSY 836
            +  E E ++E K+  +K  C  +K       +K    EK+ E++ I  +LEE       +
Sbjct: 1033 ERGEVEEDKENKEYSEK--CVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090

Query: 837  KQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKE----VITAQDTVIKAK 892
            +  ++ +N+ ++   +QI+++ AE+++N+  + K     T   +     +  +  VI   
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150

Query: 893  YAEVAKH-KEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHL---- 947
                ++H K +  +  L +++    + K  +EA      + K  ++      ERHL    
Sbjct: 1151 CTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQE-----KERHLREEL 1205

Query: 948  ------FGQPNSAYDFKTNNPKEAGQRLQKLQ 973
                  + +    +D ++   +  G +L++LQ
Sbjct: 1206 KQQKDDYNRLQEQFDEQSKENENIGDQLRQLQ 1237



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 186/968 (19%), Positives = 397/968 (41%), Gaps = 146/968 (15%)

Query: 182  QKTIEKKEAKLKEI---------KTILEEEITPTIQKLKEERSSYLEYQK--VMREIEHL 230
            Q+ +++K+ ++K++         K    E     ++ ++ E    LE  K  + + +EH 
Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070

Query: 231  SRLY--IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKA-LNHEIEELEKR 287
             +    +A   +L +DT+  +A  L +     +KL++EL  N + +K+ +  + E+LE+R
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQMKQKDEDLERR 2126

Query: 288  KDKETGGILR---SLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKT 344
             ++     L+   ++++ L   +R     +      +  L  ++ + ++L++N+      
Sbjct: 2127 LEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186

Query: 345  LAAKEKEVKKITDGL-HALQEASN---KDAEALAAAQQHFNAVSAGLSSNEDGAEATLAG 400
            LAA  K +  + D     + EA     K ++A+ + ++         S  +D     ++ 
Sbjct: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ-MSI 2245

Query: 401  QMMACKNDISKAQTEAK----QAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKR 456
             M   K +IS+ + + +    +AQ +++  Q+     Q E K++ S   + +    + + 
Sbjct: 2246 HMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQN 2305

Query: 457  LKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKN 516
               KLE+E+K L  +     + LEK ++     G L+       A   N +F+Y+  E +
Sbjct: 2306 ELAKLESELKSLKDQLTDLSNSLEKCKEQK---GNLEGIIRQQEADIQNSKFSYEQLETD 2362

Query: 517  WNR------------NCVKGLVASLISVKDTSATTAL---------------ELVAGERL 549
                           N  +  + SL+S K+ +   A+                L++ E  
Sbjct: 2363 LQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE 2422

Query: 550  YNVVVDTEVTGKKLLER-GELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVA-- 606
             N+V++ E   KK +++  +L      I    I  +      ++   +L    +  V   
Sbjct: 2423 ENIVLEEE--NKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDY 2480

Query: 607  -------LSLVEYKPEL--------QKAMEFVFGTTFVCD--NMDNAK---KVAFDKRIM 646
                   LS++  K +L         K  E + G     D  N +NAK   ++   +  +
Sbjct: 2481 QQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDL 2540

Query: 647  TRTVTLGGD----VFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEEL 702
             + +T+       + +     +    ++ A +  K +E ++  ++LR   N   AL+EE 
Sbjct: 2541 NQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN---ALQEEK 2597

Query: 703  AGLKNTAEKYR----QLKQQWEMKTEEADL----LQTKLQQSSYHKQQEELDALKKTIEE 754
              L    E  +    QL +Q     EE  L     Q K+++   H+      + +K I E
Sbjct: 2598 QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657

Query: 755  SEETL--------KNTKEIQRKAEEKYE-------VLENKMKNAE---AERERELKDAQK 796
             EE L        K   EI+ K +++ +       ++ N+ + AE   AE  R+L + ++
Sbjct: 2658 LEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717

Query: 797  KLDCAK-------TKADASSKKMKEKQQEVEAITLELEELKREH-TSYKQQLEAVNEAIK 848
            KL            +  +  + M   Q   +    EL+ELKR++  S K+  +   + + 
Sbjct: 2718 KLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLL 2777

Query: 849  SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQL 908
            + E       A +++   S+N  +E      E +  Q   + +K  ++     Q  DS  
Sbjct: 2778 NRERD-----ALLSETAFSMNSTEENSLSHLEKLNQQ---LLSKDEQLLHLSSQLEDSYN 2829

Query: 909  KIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQR 968
            +++     ++  + E +    ++ K  K  +    ++    QP+++   +  + K+A   
Sbjct: 2830 QVQSFSKAMASLQNERDHLWNELEKFRKSEE---GKQRSAAQPSTS-PAEVQSLKKAMSS 2885

Query: 969  LQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTI-EDLDQKKN 1027
            LQ  ++   K  +N+  + + +  E  E +   +K +     DK+K    + E+L Q+  
Sbjct: 2886 LQNDRDRLLKELKNLQQQYLQINQEITELHP--LKAQLQEYQDKTKAFQIMQEELRQE-- 2941

Query: 1028 QALNIAWQ 1035
               N++WQ
Sbjct: 2942 ---NLSWQ 2946



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 173/921 (18%), Positives = 374/921 (40%), Gaps = 160/921 (17%)

Query: 189  EAKLKEIKT-ILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKV 247
            EAK K++K  +L+ E       L + +  + E   ++R ++         Q    E   +
Sbjct: 804  EAKSKDVKIEVLQNE-------LDDVQLQFSEQSTLIRSLQS--------QLQNKESEVL 848

Query: 248  RSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQ 307
              AE ++ +  KV +L + LS+ + +I  ++  +  LEK++D ET      L+  + E  
Sbjct: 849  EGAERVRHISSKVEELSQALSQKELEITKMDQLL--LEKKRDVET------LQQTIEEKD 900

Query: 308  RVNTKSQSAFDLKKKNLACEESKRK-ELEKNMVEDSKTLAAKEKEVKKITDGLHALQEAS 366
            +  T  + +F + +K +   E K    +E   +++   L ++ +E KK         E  
Sbjct: 901  QQVT--EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKK---------EQV 949

Query: 367  NKDAEALAAAQQHFNAVS-AGLSSNED--------------------------------- 392
             +D E  +  +Q+++ +S AG  S E+                                 
Sbjct: 950  EEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRV 1009

Query: 393  -GAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQE-----LKNKQAEVKKMDSGYRK 446
               E  LA      K +I  ++TE  + +   ++ +        K ++ E+    +   K
Sbjct: 1010 SRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEK 1069

Query: 447  DQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNL 506
            + E     K L+EKL AE +     +   ++L +K  Q+      + E  +A++ +   L
Sbjct: 1070 EVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISEN-QAIIQK---L 1125

Query: 507  RFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLER 566
              +  D     +   VK  V  +IS   T ++   +    E++  +  + E   KKL E 
Sbjct: 1126 ITSNTDASDGDSVALVKETV--VISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEA 1183

Query: 567  GELKRRYTIIPLNKISARCIAPET---------LRVAQNLVGPDNVHVALSLVEYKPELQ 617
              L  R  I+   +   R +  E          L+   +    +N ++   L + + +++
Sbjct: 1184 --LTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVR 1241

Query: 618  KAMEFVFGTTFV---CDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASI 674
            ++++    +T     C +    ++  F       T      V + +      + S+ AS 
Sbjct: 1242 ESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQP----VLESNLCPDWPSHSEDASA 1297

Query: 675  LTKFQELKDVQDELRIKENELRALEEELAG----LKNTAEKYRQLKQQWEMKTEEADLLQ 730
            L     +  ++ +L+  E E   LE +++     L   +E+  QL++Q   +  E + L+
Sbjct: 1298 LQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLK 1357

Query: 731  TKLQQSSYHKQQEELDALKKTIEESE---ETLKNTKEIQRKAEEKYEVLENKMKNAE--- 784
            T   ++  H +     +L++ +E S+     L++ +E+Q K +E  +++  K ++     
Sbjct: 1358 TVSHEAEVHAE-----SLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLS 1412

Query: 785  ---AERERELKDAQKKL----DCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
               +E+E  L   Q ++    D  K        + KE  + ++ + +EL E+       K
Sbjct: 1413 GQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEM-------K 1465

Query: 838  QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVA 897
            Q+ E + E  ++ +     + A +   KE++   +E  + Q+E+  A+ T+ +   +   
Sbjct: 1466 QKPEEIGEESRAKQQIQRKLQAALISRKEAL---KENKSLQEELSLARGTIERLTKS--- 1519

Query: 898  KHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDF 957
                        + +++  +S   +E +    +++ + ++ D +  E       N +   
Sbjct: 1520 ------------LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSS 1567

Query: 958  KTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVL---TEAEERYNDLMKKKRI------- 1007
               + K A   L+ L E KEKL + +     + +   TE +E++ +L K+  I       
Sbjct: 1568 SCESLKLA---LEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYEN 1624

Query: 1008 VENDKSKILTTIEDLDQKKNQ 1028
            V N+  +I   +E + Q+K +
Sbjct: 1625 VSNEAERIQHVVEAVRQEKQE 1645



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 167/915 (18%), Positives = 361/915 (39%), Gaps = 105/915 (11%)

Query: 166  EEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQK----LKEERSSY-LEY 220
            EE A  +    K+I   +T   +  + KE K   E+ +T   Q+    LK+  S   +E 
Sbjct: 1014 EELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVEL 1073

Query: 221  QKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHE 280
            Q + +++E        +Q L+ +  +      L++  +++  LQ E+SEN   I+ L   
Sbjct: 1074 QHIRKDLEEKLAAEEQFQALVKQMNQT-----LQDKTNQIDLLQAEISENQAIIQKL--- 1125

Query: 281  IEELEKRKDKETGGILRSLEDALAEAQRVNTKSQS-AFDLKKKNLACEESKRKELEKNMV 339
               +    D   G  +  +++ +  +      S+    +L++K LA E+ K ++L+K + 
Sbjct: 1126 ---ITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEK-EQLQKKLQ 1181

Query: 340  EDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLA 399
            E    L +++  +KK  +    L+E   +  +     Q+ F+  S     NE+  +    
Sbjct: 1182 E---ALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQS---KENENIGDQLRQ 1235

Query: 400  GQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDS-----------GYRKDQ 448
             Q+   ++   K  +  +Q         +E   K  E                  + +D 
Sbjct: 1236 LQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA 1295

Query: 449  EALEA------VKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLAR 502
             AL+       +K   +++EAE  +L  + +   S L K+   S ++ +L+E        
Sbjct: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK---SEEVFQLQEQINKQGLE 1352

Query: 503  FPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKK 562
              +L+    + E +              S++    ++ L++   E L  +    +   +K
Sbjct: 1353 IESLKTVSHEAEVHAE------------SLQQKLESSQLQIAGLEHLRELQPKLDEL-QK 1399

Query: 563  LLERGELKRRYTIIPLNKISARCIAPETLRVAQ-NLVGPDNVHVALSLVEYKPELQKAME 621
            L+ + E    Y    L++  A     +T  + Q +L+   +  + +   E+   +++   
Sbjct: 1400 LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ- 1458

Query: 622  FVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTK--FQ 679
                   +C+     +++  + R   +                   + QAA I  K   +
Sbjct: 1459 -----VELCEMKQKPEEIGEESRAKQQIQR----------------KLQAALISRKEALK 1497

Query: 680  ELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ----QWEMKTEEADLLQTKLQQ 735
            E K +Q+EL +    +  L + LA +++      + K     +  +  EE D L T++ +
Sbjct: 1498 ENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDR 1557

Query: 736  SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQ 795
            S    Q     +L  + E  +  L+   E + K  ++ E L++       E + + K+ Q
Sbjct: 1558 SLLENQ-----SLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612

Query: 796  KKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIE 855
            K+ +      +  S + +  Q  VEA+  E +EL  +  S +   +   + ++  E ++E
Sbjct: 1613 KEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME 1672

Query: 856  VMAAEVAK----NKESVNKAQEEVTK-QKEVITAQDTV---IKAKYAEVAKHKEQNNDSQ 907
             M  ++ K     ++ + + +EE  + + EV  A DT    ++   +  A  KE+    +
Sbjct: 1673 EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK 1732

Query: 908  LKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQ 967
            ++ + L         E +D  ++  + LK     N  +    +    +D +TN  +E  Q
Sbjct: 1733 MEYETLSKKFQSLMSE-KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ 1791

Query: 968  RLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKN 1027
             +    E ++ L  +        +  A+     + K      +   +I   ++ +DQ K 
Sbjct: 1792 SIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKD----FSSHDEINNYLQQIDQLKE 1847

Query: 1028 QALNIAWQK-VNKDF 1041
            +   +  +K  NK+F
Sbjct: 1848 RIAGLEEEKQKNKEF 1862



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 139/779 (17%), Positives = 308/779 (39%), Gaps = 119/779 (15%)

Query: 180 AAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREI-EHLSRL----- 233
           AAQ+ + +K+A+ +    + E+E+   + +   E     + + + R++ EH   L     
Sbjct: 214 AAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQ 273

Query: 234 ---YIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIE-ELEKRK- 288
               +  +   AE      +++L++M+ +   L+  +    ++ K L  ++E E+ +RK 
Sbjct: 274 VVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKL 333

Query: 289 -----DKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSK 343
                 +E   +L   E A           Q+  +L+ +  A E+  + E+E    E + 
Sbjct: 334 SFHNLQEEMHHLLEQFEQA----------GQAQAELESRYSALEQKHKAEME----EKTS 379

Query: 344 TLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMM 403
            + + +K  +++     AL++ ++K  +                  NE   ++    Q +
Sbjct: 380 HILSLQKTGQELQSACDALKDQNSKLLQ----------------DKNEQAVQSAQTIQQL 423

Query: 404 ACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRK-DQEALEAVKRLKEKLE 462
             ++ + +   E  Q   +L   Q E  ++ +     + G +   +E + ++++   +LE
Sbjct: 424 --EDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELE 481

Query: 463 AEMKKLNYEENKEESLLEKRRQLSRDIGRL----------KETYEALLARFPNLRFAY-- 510
            E   L     + E L  +  +LS  I  L          +E  E  +    N R +   
Sbjct: 482 NEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE 541

Query: 511 ---KDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERG 567
              +D  +N      K L   L+ +K+     A E +A  +L       E    ++L++ 
Sbjct: 542 ESGQDVLENTFSQKHKELSVLLLEMKE-----AQEEIAFLKLQLQGKRAEEADHEVLDQK 596

Query: 568 ELKRRYTIIPLNKISARCIAPETLRVAQNLVGPD-----NVHVALSLVEYKPELQKAMEF 622
           E+K         ++    IAP  ++V     G D     N   +L  VE +   Q + E 
Sbjct: 597 EMK---------QMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE---QASTEH 644

Query: 623 VFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELK 682
              T+      D   ++   K+   ++++   D+   H       +SQ   +   F + +
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQ 704

Query: 683 DVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQ 742
           +      I E  L    +E++ L    E++++                            
Sbjct: 705 E------IYEKNLDEKAKEISNLNQLIEEFKK-------------------------NAD 733

Query: 743 EELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELK-DAQKKLDCA 801
               A     EE ++ L   KE+    E + +V + +M  AEAER+R L  ++Q   D  
Sbjct: 734 NNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL 793

Query: 802 KTKADAS-SKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860
            T+   S S + K K  ++E +  EL++++ + +     + ++   +++ ES++   A  
Sbjct: 794 LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAER 853

Query: 861 VAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISK 919
           V      V +  + +++++  IT  D ++  K  +V   ++   +   ++ E+  ++++
Sbjct: 854 VRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTE 912



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 172/928 (18%), Positives = 368/928 (39%), Gaps = 137/928 (14%)

Query: 182  QKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL 241
            Q+TIE+K+ ++ EI   + E++   +Q  +E+ S  +E + +  ++  LSR         
Sbjct: 893  QQTIEEKDQQVTEISFSMTEKM---VQLNEEKFSLGVEIKTLKEQLNLLSR--------- 940

Query: 242  AEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKA-LNHEIEELEKRKDKETGGILRSLE 300
            AE+ K    EE  E+   + +  +E+S   +  K  L HE + L+K  ++    +  +L 
Sbjct: 941  AEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALI 1000

Query: 301  DALAEAQRVNTKSQSAFDLK---KKNLACEESKRKELEK---NMVEDSKTLAAKEKEVKK 354
            +     QRV+   +   +LK   KK +   E++R E+E+   N     K + +K +E++ 
Sbjct: 1001 NRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEI 1060

Query: 355  ITDGLHALQEAS----NKDAEALAAAQQHFNAV------------------SAGLSSNE- 391
                  + +E       KD E   AA++ F A+                   A +S N+ 
Sbjct: 1061 YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQA 1120

Query: 392  -------------DGAEATLAGQMMAC---------------KNDISKAQTEAKQAQMKL 423
                         DG    L  + +                 +  I   + E +Q Q KL
Sbjct: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180

Query: 424  -----------KHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYE- 471
                       K AQ++ ++ + E+K+    Y + QE  +   +  E +  ++++L  + 
Sbjct: 1181 QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQV 1240

Query: 472  -ENKEESLLEKRRQ--------LSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCV 522
             E+ +  L    +Q        L   + +  E +        NL   +  P  + + + +
Sbjct: 1241 RESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDW--PSHSEDASAL 1298

Query: 523  KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
            +G   S+  +K  +    +E    E    V   T    KK  E  +L+ +     L   S
Sbjct: 1299 QG-GTSVAQIK--AQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIES 1355

Query: 583  ARCIAPETLRVAQNL---VGPDNVHVA--LSLVEYKP---ELQKAMEFVFGTTFVCDNMD 634
             + ++ E    A++L   +    + +A    L E +P   ELQK +              
Sbjct: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415

Query: 635  NAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENE 694
            + K+ A  K I T  +     +   H  L   A+     I     EL +++ +      E
Sbjct: 1416 SEKEAALTK-IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE 1474

Query: 695  LRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEE 754
             RA ++    L+      ++  ++ +   EE  L +  +++ +  K   ++++      +
Sbjct: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLT--KSLADVESQVSAQNK 1532

Query: 755  SEETLKNTKEIQRKAEEKY------EVLENKMKNAEAER-----ERELKDAQK---KLDC 800
             ++T+     + ++  +K        +LEN+  ++  E      E   +D +K   +++ 
Sbjct: 1533 EKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIES 1592

Query: 801  AKTKADASS----KKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEV 856
             K+   A S    +K KE Q+E E +    E +  E    +  +EAV +  +    ++  
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652

Query: 857  MAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHN 916
              A   + ++ + +A++E+ + KE +       K+K  ++ + +E+N+  + ++    H 
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMR---KFAKSKQQKILELEEENDRLRAEV----HP 1705

Query: 917  ISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMK 976
                 +E  +     +  +K+      ER        +  F+ +   E     +++Q++K
Sbjct: 1706 AGDTAKECMETLLSSNASMKE----ELERVKMEYETLSKKFQ-SLMSEKDSLSEEVQDLK 1760

Query: 977  EKLGRNVNMRAMNVLTEAEERYNDLMKK 1004
             ++  NV+ +A    TE  +   ++ ++
Sbjct: 1761 HQIEGNVSKQANLEATEKHDNQTNVTEE 1788



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 178/915 (19%), Positives = 345/915 (37%), Gaps = 190/915 (20%)

Query: 235  IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIK-----------ALNHEIEE 283
            +AY   L  + K    ++  ++Q K   LQEE    D KIK           +LN  IEE
Sbjct: 54   LAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEE 113

Query: 284  LE----------------------------------KRKDKETGGILRSLEDALAEAQRV 309
            ++                                  K K +E   ++ +L+  L +AQ  
Sbjct: 114  MKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQ-A 172

Query: 310  NTKSQSAFDLKKKNLACEESKRKE---------LEKNMVEDSKTLAAKEKEVKKITD-GL 359
               +QS+ ++++  +  ++ + KE         L +   E +     +EK+ +  T   L
Sbjct: 173  EQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRL 232

Query: 360  H---ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
            H    LQ  +  D E     QQ    +   L  +E+    +L G+       +   Q E 
Sbjct: 233  HEDELLQLVTQADVE--TEMQQKLRVLQRKLEEHEE----SLVGRAQV----VDLLQQEL 282

Query: 417  KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEM--KKLNYEENK 474
              A+ + +   Q+L+  +AE   + +    ++   E  K L EK+E E+  +KL++   +
Sbjct: 283  TAAEQRNQILSQQLQQMEAEHNTLRNTVETER---EESKILLEKMELEVAERKLSFHNLQ 339

Query: 475  EE--SLLEKRRQLSRDIGRLKETYEALLARFPN---------LRFAYKDPEKNWNRNCVK 523
            EE   LLE+  Q  +    L+  Y AL  +            L       E     + +K
Sbjct: 340  EEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALK 399

Query: 524  GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLN---- 579
               + L+  K+  A  + + +  ++L + +        + L R  L++  T    +    
Sbjct: 400  DQNSKLLQDKNEQAVQSAQTI--QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDV 457

Query: 580  -KISARCIAPETLRVAQ-NLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAK 637
                 + +  E +   Q  +V  +N   AL L   + E  KA      +        N  
Sbjct: 458  YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517

Query: 638  KVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASIL-----TKFQELKDVQDELRIKE 692
              A D+ +   ++       D     S  A      +L      K +EL  +  E++  +
Sbjct: 518  GEA-DREVSEISIV------DIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQ 570

Query: 693  NELRALEEELAGLKNTAEKYRQLKQQWEMK---------------------------TEE 725
             E+  L+ +L G K   E   ++  Q EMK                            EE
Sbjct: 571  EEIAFLKLQLQG-KRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEE 629

Query: 726  ADLLQTKLQQSSYHKQ---QEELD------ALKKTIEESEETLKNTKEIQRKAEEKYEVL 776
            + L   + +Q+S   Q    EE+        LK T ++ +++L    +I +  +++ E L
Sbjct: 630  SSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERL 689

Query: 777  ENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSY 836
            ++++   E    +  +  +K LD              EK +E+  +   +EE K+   + 
Sbjct: 690  KSQILELELNFHKAQEIYEKNLD--------------EKAKEISNLNQLIEEFKKNADNN 735

Query: 837  KQQLEAVNEAIKSYESQIEVMA------AEVAKNKESVNKAQEEVTKQKEVITAQDTVIK 890
                 A++E      SQ++ ++      A+V + + ++ +A+ +     E  TA D ++ 
Sbjct: 736  SSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLL- 794

Query: 891  AKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQ 950
                      EQ +   ++ K  D  I   + E +D   + S+          +  L   
Sbjct: 795  ---------TEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSE----------QSTLIRS 835

Query: 951  PNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVEN 1010
              S    K +   E  +R++ +    E+L + ++ + + + T+ ++    L++KKR VE 
Sbjct: 836  LQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEI-TKMDQL---LLEKKRDVET 891

Query: 1011 DKSKILTTIEDLDQK 1025
                +  TIE+ DQ+
Sbjct: 892  ----LQQTIEEKDQQ 902



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 81/374 (21%), Positives = 161/374 (43%), Gaps = 66/374 (17%)

Query: 680  ELKDVQDELRIKENELRALEEELAGLKNTAE-KYRQLKQQWEMKTEEADLLQTKLQQSSY 738
            ELKD+   +R K+ +L+  +E L   +  A+ K ++LK            L  K + +S 
Sbjct: 63   ELKDI---IRQKDVQLQQKDEALQEERKAADNKIKKLK------------LHAKAKLTSL 107

Query: 739  HKQQEELDALKKTI----EESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDA 794
            +K  EE+ A   T+     +SEE L  +K  +   EE+ E+   K+K+   E+E  +   
Sbjct: 108  NKYIEEMKAQGGTVLPTEPQSEEQL--SKHDKSSTEEEMEI--EKIKHKLQEKEELISTL 163

Query: 795  QKKLDCAKTKADASSK-------KMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAI 847
            Q +L  A+ +  A S         MK++ QE E     L+    +  + +   + V E  
Sbjct: 164  QAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKD 223

Query: 848  KSYESQIEVMAAEV----------AKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVA 897
              +E+Q+ +   E+           + ++ +   Q ++ + +E +  +  V+     E+ 
Sbjct: 224  ARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELT 283

Query: 898  KHKEQNN--DSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAY 955
              +++N     QL+  E +HN  ++  E E   +K+  +L+  +   AER L     S +
Sbjct: 284  AAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKI--LLEKMELEVAERKL-----SFH 336

Query: 956  DFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKI 1015
            + +        + +  L E  E+ G+           E E RY+ L +K +    +K+  
Sbjct: 337  NLQ--------EEMHHLLEQFEQAGQ--------AQAELESRYSALEQKHKAEMEEKTSH 380

Query: 1016 LTTIEDLDQKKNQA 1029
            + +++   Q+   A
Sbjct: 381  ILSLQKTGQELQSA 394



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 89/448 (19%), Positives = 179/448 (39%), Gaps = 78/448 (17%)

Query: 663  LSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ----- 717
            L+     Q A   T+ +E   ++ +L+ KE  +  L+ +L+  +      + +++     
Sbjct: 167  LTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARF 226

Query: 718  QWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
            + +++  E +LLQ   Q     + Q++L  L++ +EE EE+L    ++        ++L+
Sbjct: 227  ETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV-------VDLLQ 279

Query: 778  NKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
             ++  AE                                Q  + ++ +L++++ EH + +
Sbjct: 280  QELTAAE--------------------------------QRNQILSQQLQQMEAEHNTLR 307

Query: 838  QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEE---VTKQKEVITAQDTVIKAKYA 894
              +E   E  K     +E M  EVA+ K S +  QEE   + +Q E        ++++Y+
Sbjct: 308  NTVETEREESKIL---LEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYS 364

Query: 895  EV-AKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQP-N 952
             +  KHK +  +    I  L     + +   +    + SK+L+D    N +     Q   
Sbjct: 365  ALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDK---NEQAVQSAQTIQ 421

Query: 953  SAYDFKTNNPKEAGQRLQKLQ-EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIV--E 1009
               D      KE  Q L +L  +  E   +       N  T+A    N    +KR+V  E
Sbjct: 422  QLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELE 481

Query: 1010 NDKSKILTTIEDLDQKKNQALNIAWQ-----------KVNKDFGSIFSTLLPGANAMLAP 1058
            N+K  +L +  +L++ K +   ++ Q           + +++   I    +    +  A 
Sbjct: 482  NEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE 541

Query: 1059 PEGQTVLDGLEFKVALGNTWKENLTELS 1086
              GQ VL+         NT+ +   ELS
Sbjct: 542  ESGQDVLE---------NTFSQKHKELS 560



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 67/334 (20%), Positives = 139/334 (41%), Gaps = 49/334 (14%)

Query: 177  KKIAAQKTIEKKEAK-LKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYI 235
            ++ AAQ +    E + LK+  + L+ +    +++LK  +  YL+  + + E+  L     
Sbjct: 2863 QRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQ 2922

Query: 236  AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKR-------- 287
             YQ    + TK     + +E++ + +  Q EL  +  +++  + EI E   +        
Sbjct: 2923 EYQ----DKTKAFQIMQ-EELRQENLSWQHEL--HQLRMEKSSWEIHERRMKEQYLMAIS 2975

Query: 288  -KDKETG---GILRSLEDALAEAQRVNTKSQ-------SAFDLKKKNLACEESKRKELEK 336
             KD++      ++R L  + ++ Q +  + Q       SA     +NL  E     EL +
Sbjct: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYE----TELLR 3031

Query: 337  NMVEDS-KTLAAKEKEVKKITDGLHALQEASN-------KDAEALAAAQQHFNAVSAGLS 388
              + DS K +  KE  ++++      L E  N         +++L   QQH+  +    +
Sbjct: 3032 TQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCA 3091

Query: 389  SNEDGAEATLAGQMMAC--------KNDISKAQ--TEAKQAQMKLKHAQQELKNKQAEVK 438
              E   +   AG +           KN + +     E ++ Q     AQQ+L N + EV 
Sbjct: 3092 VLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVN 3151

Query: 439  KMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEE 472
            ++     ++++   A +      E ++++L + E
Sbjct: 3152 ELRKLLEEERDQRVAAENALSVAEEQIRRLEHSE 3185



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 62/293 (21%), Positives = 132/293 (45%), Gaps = 23/293 (7%)

Query: 734  QQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKD 793
            Q+S         + +++ +  +E+ +   K+I R+ +     ++ + K+   + ER+  D
Sbjct: 36   QESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKD-----VQLQQKDEALQEERKAAD 90

Query: 794  AQ-KKLDC-AKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYE 851
             + KKL   AK K  + +K ++E + +   +      L  E  S ++QL   +++    E
Sbjct: 91   NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTV------LPTEPQS-EEQLSKHDKSSTEEE 143

Query: 852  SQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK 911
             +IE +  ++ + +E ++  Q ++T+ +    AQ +    +  E    K+Q  + +  I 
Sbjct: 144  MEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSS---TEMEEFVMMKQQLQEKEEFIS 200

Query: 912  ELDHNISKHKREAEDGAAKV--SKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRL 969
             L   +S  + +AE  A +V   K  +    +        Q  +  D +T   ++     
Sbjct: 201  TLQAQLS--QTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQ 258

Query: 970  QKLQEMKEKL-GR-NVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
            +KL+E +E L GR  V       LT AE+R   L ++ + +E + + +  T+E
Sbjct: 259  RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVE 311



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 55/269 (20%), Positives = 109/269 (40%), Gaps = 44/269 (16%)

Query: 674  ILTKFQELKDVQDELRIKENELRALEEELAGLKNTA-------EKYRQLKQQWEMKTEEA 726
            +L+K ++L  +  +L    N++++  + +A L+N         EK+R        K+EE 
Sbjct: 2810 LLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR--------KSEEG 2861

Query: 727  DLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAE 786
                     +S  + Q    A+     + +  LK  K +Q    ++Y  +  ++      
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ----QQYLQINQEI------ 2911

Query: 787  RERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNE- 845
               EL   + +L   + K  A     +E +QE  +   EL +L+ E +S++     + E 
Sbjct: 2912 --TELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQ 2969

Query: 846  ---AIKSYESQIEVMAAEVAKNKESVN-----KAQEEVTKQKEVITAQDTVIKAKYAEVA 897
               AI   + Q+  +   + + + S +     K Q +     E   + D      Y E  
Sbjct: 2970 YLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVY-ETE 3028

Query: 898  KHKEQNNDS-------QLKIKELDHNISK 919
              + Q NDS       +L+I++L+ N S+
Sbjct: 3029 LLRTQLNDSLKEIHQKELRIQQLNSNFSQ 3057


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  102 bits (255), Expect = 2e-21
 Identities = 189/959 (19%), Positives = 396/959 (41%), Gaps = 130/959 (13%)

Query: 150  ITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQK 209
            +T+ L+ K   I  + EE      YE K    +K +EK + K KE++  L++++     K
Sbjct: 927  LTQKLSAKEDSIHILNEE------YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK 980

Query: 210  LKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSE 269
            LK+E       +    E+    + + A    +A+      ++ +  ++    +  E L+E
Sbjct: 981  LKKE------LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034

Query: 270  NDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL--ACE 327
              ++   LN  I   EK+ +++   +    E  L E      K Q   +LK+K L   CE
Sbjct: 1035 VHRR--ELNDVISIWEKKLNQQAEELQEIHEIQLQE------KEQEVAELKQKILLFGCE 1086

Query: 328  -ESKRKE---LEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAV 383
             E   KE   L++  V+   TL   ++++K+ +  +++L +   K    L   +   N  
Sbjct: 1087 KEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNK- 1145

Query: 384  SAGLSSNEDGAEATLAGQMMA--CKNDISKAQTEAKQAQMKLKH--AQQELKNKQAEVKK 439
               L  N    E  +  +M+A   K  +S+  ++ K    + +   +  E  NK  E K 
Sbjct: 1146 --SLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203

Query: 440  MDSGYRKDQEALE---AVKRLKEKLEAEMKKL-NYEENKEESLLEKRRQLSRDIGRLKET 495
            ++     ++ A++     K+ +  LEA+  +L N   +K  ++L +         ++KE 
Sbjct: 1204 LEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEA 1263

Query: 496  Y----------EALLARFP------NLRFAYKDPEKNWNRNCVKGLVA---SLISVKDT- 535
                       EA L +        N+ F     +     N +K + A   SL++ K+  
Sbjct: 1264 LLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL 1323

Query: 536  ---------------SATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNK 580
                           S  T L+    E +  V +  E   +K +E   L ++ T + +  
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ- 1382

Query: 581  ISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVA 640
                          QN +       A+S +  + + +K           C+ +D  + ++
Sbjct: 1383 -------------LQNSISLSEKEAAISSLRKQYDEEK-----------CELLDQVQDLS 1418

Query: 641  FDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQE-LKDVQDELRIKENELRALE 699
            F    +++      +  D         + +A S  T+ Q  +K++Q +L +K  E    +
Sbjct: 1419 FKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD 1478

Query: 700  EELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETL 759
            E++  LK   E+  Q  ++++    E +  ++K+++   + + E      + +E  +   
Sbjct: 1479 EQINLLK---EELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535

Query: 760  KNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV 819
            + T EI        E L   +KN   +++ E K+  +KL   +   +    ++KE ++++
Sbjct: 1536 QKTIEI--------ESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKI 1587

Query: 820  EAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVM-----AAEVAKNKESVNKAQEE 874
              +  ++  +K E  + K++LE VN ++KS E +++ +     +   AK  E   KA+++
Sbjct: 1588 LTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQK 1647

Query: 875  VTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAK---- 930
            +   K+ + +Q    + +Y +  +      +++L+ +E + +I + K ++ + +      
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLI 1707

Query: 931  VSKMLKDYDWINAERHLFGQ--PNSAYDFKTN----NPKEAGQRLQKL-QEMKEKLGRNV 983
            V +  K+      +     Q      Y+ K +    N  E  + LQ++ QE +E +  + 
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767

Query: 984  NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFG 1042
             MR      + +ER   L   +     D+S I    E+L++K  +   I  Q V K+ G
Sbjct: 1768 EMRC-----QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGG 1821



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 187/946 (19%), Positives = 374/946 (39%), Gaps = 166/946 (17%)

Query: 196  KTILEEEITPTIQKLKEERSSYL-EYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELK 254
            K  L+E++   +Q+L++ +  ++ E  K++ ++     L       L +D  +  AE  +
Sbjct: 316  KEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ----LEQDKGMVIAETKR 371

Query: 255  EMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNT--- 311
            +M + +   +EE+++   +IK +  + EEL ++K+K        LE AL+ AQ+      
Sbjct: 372  QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431

Query: 312  KSQSAFDLKKKNL------------------------ACEESKRKELEKNMVEDSKTLAA 347
            K ++  D + K +                          ++S  +++ K      K LA 
Sbjct: 432  KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELAR 491

Query: 348  KEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKN 407
            KE+E+ K       LQ    +  E +  A +   +    +S  ++  E+    ++   K 
Sbjct: 492  KEQELTK------KLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKK 545

Query: 408  DISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD-QEALEAVKRLKEKLEAEMK 466
             I        +++ KL+  QQE +  +  + +++S   K  QE     K L   LEAE  
Sbjct: 546  AI------LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599

Query: 467  KLNYEENKEESLLEKRRQLSRDIGRLKETYEALLA-RFPNLRFAYKDPEKNWNRNCVKGL 525
            K     NKE +++ ++ +   ++  LK   +AL   +   L+  Y+   +     C +  
Sbjct: 600  K----HNKEITVMVEKHKT--ELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEK 653

Query: 526  VASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS--- 582
               L   KD        +             E   +K LE+ ++K+       +++S   
Sbjct: 654  ETLL---KDKEIIFQAHI-------------EEMNEKTLEKLDVKQTELESLSSELSEVL 697

Query: 583  -ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAF 641
             AR    E L V ++        +   + E K   Q+ ++ +     V  ++   +K   
Sbjct: 698  KARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEV--SIQRTEKALK 755

Query: 642  D----------------KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDV- 684
            D                K        L  D+    G L      QA++ L  FQ  +   
Sbjct: 756  DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQ-----QASAKLDVFQSYQSAT 810

Query: 685  QDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEE 744
             ++ +  E +L  L+++L  L+   E+    KQ  E++ ++ D+               E
Sbjct: 811  HEQTKAYEEQLAQLQQKLLDLET--ERILLTKQVAEVEAQKKDVCT-------------E 855

Query: 745  LDALKKTIEESEETL-KNTKEIQRKAEEKYEVLENKMKNAEAERER-------------E 790
            LDA K  +++  + L K   E+++K +   +V E+K+++   E+E+             +
Sbjct: 856  LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915

Query: 791  LKDAQKK---------------LDCAKTKADASSKKMKEKQQEVEAITLELEE-----LK 830
            +++ QKK               +     + +   K  ++K ++V+    E++E     L 
Sbjct: 916  MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975

Query: 831  REHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK-NKESVNKAQEEV-TKQKEVITAQDTV 888
             +    K++LE     +   E Q      E+A+ N   ++ A   + T QKE I +   V
Sbjct: 976  DQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035

Query: 889  IKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAK---------VSKMLKDYD 939
             + +  +V    E+  + Q +  +  H I   ++E E    K           +M K+  
Sbjct: 1036 HRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEIT 1095

Query: 940  WINAE----RHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAE 995
            W+  E         +       K+ +     Q   KL+   EKL  ++N +++   T  +
Sbjct: 1096 WLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLN-KSLKENTFLQ 1154

Query: 996  ERYNDLMKKKRIVENDKSKI--LTTIEDLDQKKNQALNIAWQKVNK 1039
            E+   L++ K + E DK K+  LT+      ++ Q+L  + +K NK
Sbjct: 1155 EQ---LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 167/842 (19%), Positives = 339/842 (40%), Gaps = 129/842 (15%)

Query: 184  TIEKKEAKLKEIKTILEEEITPTIQKLKEE--RSSYLEYQKV--MREIEHLSRLYIAYQF 239
            ++ +KEA +  ++   +EE    + ++++   +   L  +K+  + +++  S  +  ++ 
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK- 1446

Query: 240  LLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSL 299
              A+    +    +KE+Q ++    +E  E D++I  L  E+++  KR D   G     +
Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKG----EM 1502

Query: 300  EDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGL 359
            ED            +S  + K+ NL   E++ K     ++E    +  K  E++ + + L
Sbjct: 1503 ED-----------DKSKMEKKESNL---ETELKSQTARIMELEDHITQKTIEIESLNEVL 1548

Query: 360  HALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQA 419
                +  + + + L    QHF      L   +D        +++  +N +   + E +  
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQE----LGEEKDNRVKEAEEKILTLENQVYSMKAELETK 1604

Query: 420  QMKLKHAQQELKNKQAEVKKMDSGYRKDQEA-LEAVKRLKEKLEAEMKK--LNYEENKEE 476
            + +L+H    +K+K+ E+K ++     +  A L  +KR  E+  A +KK  L+  E KEE
Sbjct: 1605 KKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEE 1664

Query: 477  S-----------LLEKRRQLSRDIGRLKETYEA---------LLARFPNLRFAYKDPEKN 516
                        L  K ++  R++  L+E  ++         ++ R      AY + E+ 
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEA 1724

Query: 517  WNRNCVKGLVASLISVKDTSATTA---LELVAGERLYNVVVDTEVTGKKL-----LERGE 568
             ++ CV+      ISV   + T     L+ V  E+   V    E+  +       LE  E
Sbjct: 1725 DSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAE 1784

Query: 569  LKRRYTIIPLNKISARCIAPE---TLRVAQNLV---GPDNVHVALSLVEYKPELQKAMEF 622
             K+      +  +           +L VAQ++    G +N+    +L     ++QK ++ 
Sbjct: 1785 AKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ- 1843

Query: 623  VFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELK 682
                   C  ++   K      +  + V                 R +   + +K+++L+
Sbjct: 1844 --EKELTCQILEQKIKELDSCLVRQKEVH----------------RVEMEELTSKYEKLQ 1885

Query: 683  DVQD-ELRIKENELRALEEELAGLKNTAEKYR----QLKQQWEMKTEEADLLQTKLQQSS 737
             +Q  + R K  EL  LEE      NT EK +    Q K    M+ +  DL + KL  + 
Sbjct: 1886 ALQQMDGRNKPTEL--LEE------NTEEKSKSHLVQPKLLSNMEAQHNDL-EFKLAGAE 1936

Query: 738  YHKQ---------QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERE 788
              KQ         Q++L  L+K  ++  E LK  KE  ++ EEK   ++ + ++ E +  
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQELEILK--KEYDQEREEK---IKQEQEDLELKHN 1991

Query: 789  RELKDAQKKLDCA----KTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVN 844
              LK   ++ +      + + + + K+   K QEVEA  LE  +            E  N
Sbjct: 1992 STLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQ------------EETN 2039

Query: 845  EAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNN 904
            + +K    + + +     + +E ++  +EE+T +   +  Q   ++ KY +  + +E   
Sbjct: 2040 QLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPG 2099

Query: 905  DSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKE 964
            +  + I EL   +++      D   K  +  +     N E  L     + Y      P +
Sbjct: 2100 NDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH--NLEDRLKKYEKNVYATTVGTPYK 2157

Query: 965  AG 966
             G
Sbjct: 2158 GG 2159



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 186/933 (19%), Positives = 393/933 (42%), Gaps = 126/933 (13%)

Query: 152  KVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLK 211
            K +  +  E+    E++      E +K  A  T +K E   +++K  ++E+I  TI+K  
Sbjct: 392  KQMTTQGEELREQKEKSERAAFEELEK--ALSTAQKTEEARRKLKAEMDEQI-KTIEKTS 448

Query: 212  EERSSYLEY------QKVMREIEHLSRLYIAYQFLLAEDTKVRSAEEL-KEMQDKVIKLQ 264
            EE    L+       Q+V+  ++  S   IA    L E    R  +EL K++Q +  + Q
Sbjct: 449  EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQ 508

Query: 265  EELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL 324
            E++     K+     + E L+  ++KE    L +LE+   + + + T+S++     ++  
Sbjct: 509  EQM-----KVALEKSQSEYLKISQEKEQQESL-ALEELELQKKAILTESENKLRDLQQEA 562

Query: 325  ACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVS 384
                ++  ELE ++    K+L   + + K +   L A +   NK  E     ++H     
Sbjct: 563  ETYRTRILELESSL---EKSLQENKNQSKDLAVHLEAEKNKHNK--EITVMVEKH----K 613

Query: 385  AGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQE-LKNK----QAEVKK 439
              L S +   +A    ++   K    + QTE ++ + K +  ++  LK+K    QA +++
Sbjct: 614  TELESLKHQQDALWTEKLQVLK---QQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670

Query: 440  MDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEAL 499
            M+             ++  EKL+ +  +L    ++   +L+ R +L  ++  LK+  + +
Sbjct: 671  MN-------------EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKM 717

Query: 500  LARFPNLRFAYKDPEKNWNRNCVKGLVAS-LISVKDTSAT-----TALELVAGERLYNV- 552
                     A  D +KN ++  V  ++    +S++ T          LEL+  ER  ++ 
Sbjct: 718  KQELE----AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLK 773

Query: 553  -----VVDTEVTGKKLLERGELKRRYTIIPL-------NKISARCIAPETLRVAQNLVGP 600
                 V + E   K+    GEL++    + +            +    +  ++ Q L+  
Sbjct: 774  EHQAHVENLEADIKR--SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL 831

Query: 601  DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
            +   + L+    + E QK          VC  +D  K    D  +M +      ++    
Sbjct: 832  ETERILLTKQVAEVEAQK--------KDVCTELDAHKIQVQD--LMQQLEKQNSEMEQKV 881

Query: 661  GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
             +L+    S+      + ++ K +  E   KEN +  + E   G K   E    L Q+  
Sbjct: 882  KSLTQVYESKLEDGNKEQEQTKQILVE---KENMILQMRE---GQKKEIE---ILTQKLS 932

Query: 721  MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
             K +   +L  +  ++ +  Q+++++ +K+  +E +ETLK  K + ++A+ K E+    +
Sbjct: 933  AKEDSIHILNEE-YETKFKNQEKKMEKVKQKAKEMQETLKK-KLLDQEAKLKKELENTAL 990

Query: 781  KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAIT-LELEELKREHTSYKQQ 839
            + ++ E++   K  +     +   +DA S+    +++++E++T +   EL    + ++++
Sbjct: 991  ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK 1050

Query: 840  LEAVNEAIKS-YESQIEVMAAEVAKNKESV-------NKAQEEVTKQKEVITAQDTVIKA 891
            L    E ++  +E Q++    EVA+ K+ +        +  +E+T  KE    QDT +  
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN- 1109

Query: 892  KYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAE----RHL 947
                  + +EQ       +  L  + +K K   E     ++K LK+  ++  +    + L
Sbjct: 1110 ------ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML 1163

Query: 948  FGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEER--YNDLMKKK 1005
              +        T+  K   +  Q L+   EK  +++  +++     +EE     D+  KK
Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKK 1223

Query: 1006 RIVENDKSKILTTIEDLDQKKNQALNIAWQKVN 1038
                        T   L+ K N+ +NI+  K N
Sbjct: 1224 ------------TEALLEAKTNELINISSSKTN 1244



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 170/870 (19%), Positives = 344/870 (39%), Gaps = 136/870 (15%)

Query: 207  IQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDK----VIK 262
            IQ+L+    S   Y+         S L  AYQ L  E  K++    L + QDK    + +
Sbjct: 140  IQRLRRMERSLSSYRG------KYSELVTAYQMLQREKKKLQGI--LSQSQDKSLRRIAE 191

Query: 263  LQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKK 322
            L+EEL  + +  K L  E +   + KD+    +L++    L   QR+     +   LK  
Sbjct: 192  LREELQMDQQAKKHLQEEFDASLEEKDQYIS-VLQTQVSLLK--QRLRNGPMNVDVLKPL 248

Query: 323  NLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNA 382
                 +++    E+N   D + +      VK     L  LQ+   +    L   ++    
Sbjct: 249  PQLEPQAEVFTKEENPESDGEPVVEDGTSVKT----LETLQQRVKRQENLLKRCKE---- 300

Query: 383  VSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDS 442
                          T+      C    S+ +   +Q   +L+  ++      AE  K+ +
Sbjct: 301  --------------TIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLIT 346

Query: 443  GYRKDQEALEAVKRLKEKLEAEMKKLNYE--ENKEESLLEKRRQLSRDIGRLKETYEALL 500
              R  +  +E +++ K  + AE K+  +E  E KEE + + R ++ +   + +E  E   
Sbjct: 347  QLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQ-- 404

Query: 501  ARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
             +  + R A+++ EK  +           +  +       +E  + E   ++  +     
Sbjct: 405  -KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK 463

Query: 561  KKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAM 620
            +++++  +      I  L K+  + +A +   + + L   +         E++ +++ A+
Sbjct: 464  QEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER--------EFQEQMKVAL 515

Query: 621  EFVFGTTF-VCDNMDNAKKVAFD------KRIMTRTVTLGGDVFDPHGTLSGGARSQAAS 673
            E        +    +  + +A +      K I+T +     D+           + +A +
Sbjct: 516  EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDL-----------QQEAET 564

Query: 674  ILTKFQELKD-VQDELRIKENELRALEEELAGLKNTAEK-----YRQLKQQWEMKTEEAD 727
              T+  EL+  ++  L+  +N+ + L   L   KN   K       + K + E    + D
Sbjct: 565  YRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQD 624

Query: 728  LLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAER 787
             L T+  Q    + Q E++ L++  E+ +ETL   KEI  +A            + E   
Sbjct: 625  ALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA------------HIEEMN 672

Query: 788  ERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAI 847
            E+ L+    KLD  +T+ ++ S ++ E  +    +  EL  LK +    KQ+LE      
Sbjct: 673  EKTLE----KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE------ 722

Query: 848  KSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKH----KEQN 903
                          AK  E  N  Q++V          D++IK     + +     K+Q 
Sbjct: 723  --------------AKMDEQKNHHQQQV----------DSIIKEHEVSIQRTEKALKDQI 758

Query: 904  NDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPK 963
            N  +L +KE D ++ +H+   E+  A + +   +    +A+  +F     +Y   T+   
Sbjct: 759  NQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVF----QSYQSATHEQT 814

Query: 964  EAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
            +A +  ++L ++++KL   +++    +L   +    +  KK    E D  KI   ++DL 
Sbjct: 815  KAYE--EQLAQLQQKL---LDLETERILLTKQVAEVEAQKKDVCTELDAHKI--QVQDLM 867

Query: 1024 QKKNQALNIAWQKVNKDFGSIFSTLLPGAN 1053
            Q+  +  +   QKV K    ++ + L   N
Sbjct: 868  QQLEKQNSEMEQKV-KSLTQVYESKLEDGN 896



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 83/329 (25%), Positives = 142/329 (43%), Gaps = 55/329 (16%)

Query: 182  QKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLE----YQKVMREIEHLSRLYIAY 237
            QKT E+K + L+   T  E+ +    Q+ +E  SS+ E    YQ+ + ++EH        
Sbjct: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEH-------- 1782

Query: 238  QFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILR 297
                       +  +  E Q  +  LQEEL E +KK   +    + +EK   K      +
Sbjct: 1783 -----------AEAKQHEDQSMIGHLQEELEEKNKKYSLI--VAQHVEKEGGKNNIQAKQ 1829

Query: 298  SLEDALAEAQRVNTKSQSAFDLKKKNLACE--ESKRKELEKNMVEDSKTLAAKEKEVKKI 355
            +LE+   + Q+          L++K L C+  E K KEL+  +V   +    + +E+   
Sbjct: 1830 NLENVFDDVQKT---------LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSK 1880

Query: 356  TDGLHALQ--EASNKDAEAL---AAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDIS 410
             + L ALQ  +  NK  E L      +   + V   L SN +     L  ++   + +  
Sbjct: 1881 YEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQ 1940

Query: 411  KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLE----AEMK 466
            K   E  + Q  L+  ++E + +   +KK       DQE  E +K+ +E LE    + +K
Sbjct: 1941 KLGKEIVRLQKDLRMLRKEHQQELEILKK-----EYDQEREEKIKQEQEDLELKHNSTLK 1995

Query: 467  KLNYEENKEESLLEKRRQLSRDIGRLKET 495
            +L  E N +  L +K ++L   I   KET
Sbjct: 1996 QLMREFNTQ--LAQKEQELEMTI---KET 2019


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.127    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,071,307
Number of Sequences: 37866
Number of extensions: 1695530
Number of successful extensions: 29146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 518
Number of HSP's successfully gapped in prelim test: 1363
Number of HSP's that attempted gapping in prelim test: 9107
Number of HSP's gapped (non-prelim): 10398
length of query: 1197
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1083
effective length of database: 13,930,794
effective search space: 15087049902
effective search space used: 15087049902
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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