Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 110346438
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
(1287 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 2569 0.0
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 2556 0.0
gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo sa... 635 0.0
gi|110346445 FERM and PDZ domain containing 2 like 1 isoform 4 [... 632 0.0
gi|110346449 FERM and PDZ domain containing 2 like 2 isoform 4 [... 632 0.0
gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo sap... 531 e-150
gi|110346443 FERM and PDZ domain containing 2 like 1 isoform 2 [... 530 e-150
gi|110346447 FERM and PDZ domain containing 2 like 2 isoform 2 [... 530 e-150
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 489 e-138
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 367 e-101
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 297 4e-80
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 297 4e-80
gi|109715866 FERM domain containing 6 [Homo sapiens] 125 3e-28
gi|22748721 FERM domain containing 6 [Homo sapiens] 125 3e-28
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 121 5e-27
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 113 1e-24
gi|45827729 scribble isoform b [Homo sapiens] 106 2e-22
gi|45827731 scribble isoform a [Homo sapiens] 106 2e-22
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 105 3e-22
gi|161702986 ezrin [Homo sapiens] 100 1e-20
gi|21614499 ezrin [Homo sapiens] 100 1e-20
gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens] 100 2e-20
gi|148746189 multiple PDZ domain protein [Homo sapiens] 98 4e-20
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 97 1e-19
gi|4505257 moesin [Homo sapiens] 95 4e-19
gi|4506467 radixin [Homo sapiens] 95 5e-19
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 95 5e-19
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 95 5e-19
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 95 5e-19
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 95 5e-19
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 2569 bits (6658), Expect = 0.0
Identities = 1287/1287 (100%), Positives = 1287/1287 (100%)
Query: 1 MQPLTKDAGMSLSSVTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSSDYVVCPW 60
MQPLTKDAGMSLSSVTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSSDYVVCPW
Sbjct: 1 MQPLTKDAGMSLSSVTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSSDYVVCPW 60
Query: 61 SALLSAAGSLSFQGRVSHIEAAPFKAPELLQGQSEDEQPDASQPLQLCEPLHSILLTMCE 120
SALLSAAGSLSFQGRVSHIEAAPFKAPELLQGQSEDEQPDASQPLQLCEPLHSILLTMCE
Sbjct: 61 SALLSAAGSLSFQGRVSHIEAAPFKAPELLQGQSEDEQPDASQPLQLCEPLHSILLTMCE 120
Query: 121 DQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTISEVEKRVVEESSSVQ 180
DQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTISEVEKRVVEESSSVQ
Sbjct: 121 DQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTISEVEKRVVEESSSVQ 180
Query: 181 QNRSYLLRKRLRGTSSESPAAQAPECLHPCRVSERSTETQSSPEPHWSTLTHSHCSLLVN 240
QNRSYLLRKRLRGTSSESPAAQAPECLHPCRVSERSTETQSSPEPHWSTLTHSHCSLLVN
Sbjct: 181 QNRSYLLRKRLRGTSSESPAAQAPECLHPCRVSERSTETQSSPEPHWSTLTHSHCSLLVN 240
Query: 241 RALPGADPQDQQAGRRLSSGSVHSAADSSWPTTPSQRGFLQRRSKFSRPEFILLAGEAPM 300
RALPGADPQDQQAGRRLSSGSVHSAADSSWPTTPSQRGFLQRRSKFSRPEFILLAGEAPM
Sbjct: 241 RALPGADPQDQQAGRRLSSGSVHSAADSSWPTTPSQRGFLQRRSKFSRPEFILLAGEAPM 300
Query: 301 TLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTY 360
TLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTY
Sbjct: 301 TLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTY 360
Query: 361 FGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNTFTLFLRIKFFVSHYGLLQHSL 420
FGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNTFTLFLRIKFFVSHYGLLQHSL
Sbjct: 361 FGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNTFTLFLRIKFFVSHYGLLQHSL 420
Query: 421 TRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPAS 480
TRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPAS
Sbjct: 421 TRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPAS 480
Query: 481 LIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEE 540
LIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEE
Sbjct: 481 LIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEE 540
Query: 541 MALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTITSSVTGKKHTFVTDSAK 600
MALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTITSSVTGKKHTFVTDSAK
Sbjct: 541 MALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTITSSVTGKKHTFVTDSAK 600
Query: 601 TSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMANLSPAHQARSKPLIWIQRLSCS 660
TSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMANLSPAHQARSKPLIWIQRLSCS
Sbjct: 601 TSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMANLSPAHQARSKPLIWIQRLSCS 660
Query: 661 ENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQLKSACVIQKPMTW 720
ENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQLKSACVIQKPMTW
Sbjct: 661 ENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQLKSACVIQKPMTW 720
Query: 721 DSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPG 780
DSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPG
Sbjct: 721 DSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPG 780
Query: 781 IFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKG 840
IFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKG
Sbjct: 781 IFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKG 840
Query: 841 VGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRH 900
VGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRH
Sbjct: 841 VGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRH 900
Query: 901 QLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSI 960
QLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSI
Sbjct: 901 QLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSI 960
Query: 961 VPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQC 1020
VPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQC
Sbjct: 961 VPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQC 1020
Query: 1021 PSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCS 1080
PSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCS
Sbjct: 1021 PSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCS 1080
Query: 1081 HLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLL 1140
HLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLL
Sbjct: 1081 HLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLL 1140
Query: 1141 LCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLG 1200
LCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLG
Sbjct: 1141 LCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLG 1200
Query: 1201 LRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQN 1260
LRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQN
Sbjct: 1201 LRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQN 1260
Query: 1261 CYSVCDIMRLGRYSFSSPLTRLSTDIF 1287
CYSVCDIMRLGRYSFSSPLTRLSTDIF
Sbjct: 1261 CYSVCDIMRLGRYSFSSPLTRLSTDIF 1287
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 2556 bits (6625), Expect = 0.0
Identities = 1287/1309 (98%), Positives = 1287/1309 (98%), Gaps = 22/1309 (1%)
Query: 1 MQPLTKDAGMSLSSVTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSSDYVVCPW 60
MQPLTKDAGMSLSSVTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSSDYVVCPW
Sbjct: 1 MQPLTKDAGMSLSSVTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSSDYVVCPW 60
Query: 61 SALLSAAGSLSFQGRVSHIEAAPFKAPELLQGQSEDEQPDASQ----------------- 103
SALLSAAGSLSFQGRVSHIEAAPFKAPELLQGQSEDEQPDASQ
Sbjct: 61 SALLSAAGSLSFQGRVSHIEAAPFKAPELLQGQSEDEQPDASQMHVYSLGMTLYWSAGFH 120
Query: 104 -----PLQLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLV 158
PLQLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLV
Sbjct: 121 VPPHQPLQLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLV 180
Query: 159 GLVLGTISEVEKRVVEESSSVQQNRSYLLRKRLRGTSSESPAAQAPECLHPCRVSERSTE 218
GLVLGTISEVEKRVVEESSSVQQNRSYLLRKRLRGTSSESPAAQAPECLHPCRVSERSTE
Sbjct: 181 GLVLGTISEVEKRVVEESSSVQQNRSYLLRKRLRGTSSESPAAQAPECLHPCRVSERSTE 240
Query: 219 TQSSPEPHWSTLTHSHCSLLVNRALPGADPQDQQAGRRLSSGSVHSAADSSWPTTPSQRG 278
TQSSPEPHWSTLTHSHCSLLVNRALPGADPQDQQAGRRLSSGSVHSAADSSWPTTPSQRG
Sbjct: 241 TQSSPEPHWSTLTHSHCSLLVNRALPGADPQDQQAGRRLSSGSVHSAADSSWPTTPSQRG 300
Query: 279 FLQRRSKFSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDV 338
FLQRRSKFSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDV
Sbjct: 301 FLQRRSKFSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDV 360
Query: 339 ESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMN 398
ESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMN
Sbjct: 361 ESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMN 420
Query: 399 TFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFG 458
TFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFG
Sbjct: 421 TFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFG 480
Query: 459 NYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQ 518
NYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQ
Sbjct: 481 NYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQ 540
Query: 519 QLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQ 578
QLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQ
Sbjct: 541 QLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQ 600
Query: 579 KKFTITSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMA 638
KKFTITSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMA
Sbjct: 601 KKFTITSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMA 660
Query: 639 NLSPAHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIG 698
NLSPAHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIG
Sbjct: 661 NLSPAHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIG 720
Query: 699 RSPCTGREQLKSACVIQKPMTWDSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKR 758
RSPCTGREQLKSACVIQKPMTWDSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKR
Sbjct: 721 RSPCTGREQLKSACVIQKPMTWDSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKR 780
Query: 759 DPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFN 818
DPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFN
Sbjct: 781 DPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFN 840
Query: 819 MAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQD 878
MAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQD
Sbjct: 841 MAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQD 900
Query: 879 QDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTL 938
QDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTL
Sbjct: 901 QDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTL 960
Query: 939 GFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL 998
GFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL
Sbjct: 961 GFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL 1020
Query: 999 TGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEV 1058
TGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEV
Sbjct: 1021 TGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEV 1080
Query: 1059 KLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRST 1118
KLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRST
Sbjct: 1081 KLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRST 1140
Query: 1119 EGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTS 1178
EGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTS
Sbjct: 1141 EGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTS 1200
Query: 1179 PILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLC 1238
PILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLC
Sbjct: 1201 PILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLC 1260
Query: 1239 KLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYSFSSPLTRLSTDIF 1287
KLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYSFSSPLTRLSTDIF
Sbjct: 1261 KLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYSFSSPLTRLSTDIF 1309
>gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo
sapiens]
Length = 320
Score = 635 bits (1638), Expect = 0.0
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 975 GDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 1034
GDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV
Sbjct: 8 GDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
Query: 1035 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 1094
SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP
Sbjct: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
Query: 1095 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQ 1154
GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQ
Sbjct: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQ 187
Query: 1155 EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ 1214
EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ
Sbjct: 188 EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ 247
Query: 1215 WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 1274
WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS
Sbjct: 248 WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 307
Query: 1275 FSSPLTRLSTDIF 1287
FSSPLTRLSTDIF
Sbjct: 308 FSSPLTRLSTDIF 320
Score = 42.4 bits (98), Expect = 0.003
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 907 LKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPY---GGIYVKSIVPG 963
L G SSC ++ G + V+L K LGFS S + + +K + PG
Sbjct: 73 LPGRPSSCV----SVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG 128
Query: 964 GPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
PA + G I GD +L V+G GL ++ + L G Q L+L R P
Sbjct: 129 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 754 VTLKRDPHR-GFGFVINEGEYSGQADPGIF-ISSIIPGGPAEKAKTIKPGGQILALNHIS 811
V LK++ + GF FV E E + I + PG PAE+ I G ILA+N S
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 812 LEGFTFNMAVRMIQNSPDNIELII 835
EG F + +++ +P + L++
Sbjct: 151 TEGLIFQEVLHLLRGAPQEVTLLL 174
>gi|110346445 FERM and PDZ domain containing 2 like 1 isoform 4 [Homo
sapiens]
Length = 320
Score = 632 bits (1630), Expect = 0.0
Identities = 311/313 (99%), Positives = 312/313 (99%)
Query: 975 GDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 1034
GDRLLQVDGVILCGLTHKQAVQCL GPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV
Sbjct: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
Query: 1035 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 1094
SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP
Sbjct: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
Query: 1095 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQ 1154
GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPE+EQ
Sbjct: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQ 187
Query: 1155 EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ 1214
EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ
Sbjct: 188 EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ 247
Query: 1215 WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 1274
WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS
Sbjct: 248 WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 307
Query: 1275 FSSPLTRLSTDIF 1287
FSSPLTRLSTDIF
Sbjct: 308 FSSPLTRLSTDIF 320
Score = 42.4 bits (98), Expect = 0.003
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 907 LKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPY---GGIYVKSIVPG 963
L G SSC ++ G + V+L K LGFS S + + +K + PG
Sbjct: 73 LPGRPSSCV----SVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG 128
Query: 964 GPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
PA + G I GD +L V+G GL ++ + L G Q L+L R P
Sbjct: 129 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 754 VTLKRDPHR-GFGFVINEGEYSGQADPGIF-ISSIIPGGPAEKAKTIKPGGQILALNHIS 811
V LK++ + GF FV E E + I + PG PAE+ I G ILA+N S
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 812 LEGFTFNMAVRMIQNSPDNIELII 835
EG F + +++ +P + L++
Sbjct: 151 TEGLIFQEVLHLLRGAPQEVTLLL 174
>gi|110346449 FERM and PDZ domain containing 2 like 2 isoform 4 [Homo
sapiens]
Length = 320
Score = 632 bits (1630), Expect = 0.0
Identities = 311/313 (99%), Positives = 312/313 (99%)
Query: 975 GDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 1034
GDRLLQVDGVILCGLTHKQAVQCL GPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV
Sbjct: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
Query: 1035 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 1094
SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP
Sbjct: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
Query: 1095 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQ 1154
GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPE+EQ
Sbjct: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQ 187
Query: 1155 EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ 1214
EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ
Sbjct: 188 EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ 247
Query: 1215 WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 1274
WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS
Sbjct: 248 WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 307
Query: 1275 FSSPLTRLSTDIF 1287
FSSPLTRLSTDIF
Sbjct: 308 FSSPLTRLSTDIF 320
Score = 42.4 bits (98), Expect = 0.003
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 907 LKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPY---GGIYVKSIVPG 963
L G SSC ++ G + V+L K LGFS S + + +K + PG
Sbjct: 73 LPGRPSSCV----SVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG 128
Query: 964 GPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
PA + G I GD +L V+G GL ++ + L G Q L+L R P
Sbjct: 129 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 754 VTLKRDPHR-GFGFVINEGEYSGQADPGIF-ISSIIPGGPAEKAKTIKPGGQILALNHIS 811
V LK++ + GF FV E E + I + PG PAE+ I G ILA+N S
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 812 LEGFTFNMAVRMIQNSPDNIELII 835
EG F + +++ +P + L++
Sbjct: 151 TEGLIFQEVLHLLRGAPQEVTLLL 174
>gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo sapiens]
Length = 261
Score = 531 bits (1368), Expect = e-150
Identities = 261/261 (100%), Positives = 261/261 (100%)
Query: 1027 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 1086
MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL
Sbjct: 1 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 60
Query: 1087 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 1146
VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP
Sbjct: 61 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 120
Query: 1147 GALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 1206
GALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS
Sbjct: 121 GALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 180
Query: 1207 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 1266
QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD
Sbjct: 181 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 240
Query: 1267 IMRLGRYSFSSPLTRLSTDIF 1287
IMRLGRYSFSSPLTRLSTDIF
Sbjct: 241 IMRLGRYSFSSPLTRLSTDIF 261
Score = 42.4 bits (98), Expect = 0.003
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 907 LKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPY---GGIYVKSIVPG 963
L G SSC ++ G + V+L K LGFS S + + +K + PG
Sbjct: 14 LPGRPSSCV----SVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG 69
Query: 964 GPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
PA + G I GD +L V+G GL ++ + L G Q L+L R P
Sbjct: 70 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 120
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 754 VTLKRDPHR-GFGFVINEGEYSGQADPGIF-ISSIIPGGPAEKAKTIKPGGQILALNHIS 811
V LK++ + GF FV E E + I + PG PAE+ I G ILA+N S
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 812 LEGFTFNMAVRMIQNSPDNIELII 835
EG F + +++ +P + L++
Sbjct: 92 TEGLIFQEVLHLLRGAPQEVTLLL 115
>gi|110346443 FERM and PDZ domain containing 2 like 1 isoform 2 [Homo
sapiens]
Length = 261
Score = 530 bits (1366), Expect = e-150
Identities = 260/261 (99%), Positives = 261/261 (100%)
Query: 1027 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 1086
MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL
Sbjct: 1 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 60
Query: 1087 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 1146
VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP
Sbjct: 61 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 120
Query: 1147 GALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 1206
GALPE+EQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS
Sbjct: 121 GALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 180
Query: 1207 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 1266
QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD
Sbjct: 181 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 240
Query: 1267 IMRLGRYSFSSPLTRLSTDIF 1287
IMRLGRYSFSSPLTRLSTDIF
Sbjct: 241 IMRLGRYSFSSPLTRLSTDIF 261
Score = 42.4 bits (98), Expect = 0.003
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 907 LKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPY---GGIYVKSIVPG 963
L G SSC ++ G + V+L K LGFS S + + +K + PG
Sbjct: 14 LPGRPSSCV----SVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG 69
Query: 964 GPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
PA + G I GD +L V+G GL ++ + L G Q L+L R P
Sbjct: 70 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 120
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 754 VTLKRDPHR-GFGFVINEGEYSGQADPGIF-ISSIIPGGPAEKAKTIKPGGQILALNHIS 811
V LK++ + GF FV E E + I + PG PAE+ I G ILA+N S
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 812 LEGFTFNMAVRMIQNSPDNIELII 835
EG F + +++ +P + L++
Sbjct: 92 TEGLIFQEVLHLLRGAPQEVTLLL 115
>gi|110346447 FERM and PDZ domain containing 2 like 2 isoform 2 [Homo
sapiens]
Length = 261
Score = 530 bits (1366), Expect = e-150
Identities = 260/261 (99%), Positives = 261/261 (100%)
Query: 1027 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 1086
MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL
Sbjct: 1 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 60
Query: 1087 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 1146
VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP
Sbjct: 61 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 120
Query: 1147 GALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 1206
GALPE+EQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS
Sbjct: 121 GALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 180
Query: 1207 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 1266
QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD
Sbjct: 181 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 240
Query: 1267 IMRLGRYSFSSPLTRLSTDIF 1287
IMRLGRYSFSSPLTRLSTDIF
Sbjct: 241 IMRLGRYSFSSPLTRLSTDIF 261
Score = 42.4 bits (98), Expect = 0.003
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 907 LKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPY---GGIYVKSIVPG 963
L G SSC ++ G + V+L K LGFS S + + +K + PG
Sbjct: 14 LPGRPSSCV----SVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG 69
Query: 964 GPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
PA + G I GD +L V+G GL ++ + L G Q L+L R P
Sbjct: 70 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 120
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 754 VTLKRDPHR-GFGFVINEGEYSGQADPGIF-ISSIIPGGPAEKAKTIKPGGQILALNHIS 811
V LK++ + GF FV E E + I + PG PAE+ I G ILA+N S
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 812 LEGFTFNMAVRMIQNSPDNIELII 835
EG F + +++ +P + L++
Sbjct: 92 TEGLIFQEVLHLLRGAPQEVTLLL 115
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 489 bits (1259), Expect = e-138
Identities = 342/970 (35%), Positives = 516/970 (53%), Gaps = 96/970 (9%)
Query: 286 FSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAV 345
F PEF+ + E ++L LP S++TKKGK+ R + ++LLNGQ LE+ CD ++ V
Sbjct: 538 FFGPEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDV 597
Query: 346 FNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNT--FTLF 403
F+ V + L E F LA +K E+FF+D + +L K+APEGW+E+P+K + T FTLF
Sbjct: 598 FDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLF 657
Query: 404 LRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKE 463
RIKFF+ L+QH+LT HQ+YLQLRKDILEER++C++E L L LALQAE+G+Y E
Sbjct: 658 FRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPE 717
Query: 464 QVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEY 523
V YF +E Y+PA ++E++ ++ E+ ++H ++ EL+FL+V Q+L EY
Sbjct: 718 -VHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEY 776
Query: 524 GVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTI 583
GV H+V EK+ + + LG+C+KGV+V+EV N R +LRF WRET KIS +KK T+
Sbjct: 777 GVHFHRVHPEKKS-QTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITL 835
Query: 584 TSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSH-------------VLFD 630
++ G KH F TD++K +YLL LCS QH F QM + Q + ++
Sbjct: 836 QNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSS 895
Query: 631 HDKFVQMANLSP-AHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGS 689
++ + + NL A +I +++ + +F+S + A GG +D G
Sbjct: 896 PEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSV--APGG--PADLDGCLKPGD 951
Query: 690 KEAGAEGI---GRSPCTGREQLKSA-----CVIQKPMTWDSLSGPPVQSMHAGS--KNNR 739
+ + G S E L++A VI +P + +S P +H + KN
Sbjct: 952 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTPVHLTNEMKNYM 1009
Query: 740 RKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIK 799
+KS + + + +D H G + + E S G+ S+ ++ ++T
Sbjct: 1010 KKSSYMQ---DSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSL----SSQDSRT-- 1060
Query: 800 PGGQILALNHISLEGF-TFNMAVRMIQNSPDNIELIISQSKGVGGNN-PDEEKNSTANSG 857
+ +L+ + GF ++ + Q S SK D ++ T G
Sbjct: 1061 ---ESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPG 1117
Query: 858 VSSTDILSFGYQGSL----LSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSS 913
+S D+ + +G +++ QD T + + + + ++ + SS
Sbjct: 1118 IS--DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTF--------SS 1167
Query: 914 CPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQIL 973
PP P G+I+ VEL K D +LG SVTGG+NTSV +GGIYVK+++P G A +G+I
Sbjct: 1168 SPPKP-----GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIH 1222
Query: 974 QGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLER--------RVPRSTQQCPSAND 1025
+GDR+L V+GV L G THKQAV+ L GQV L+LE+ VP + Q S +
Sbjct: 1223 KGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQN 1282
Query: 1026 SMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSD 1085
+ G V T + VT+ FEVKL KN++GLGFSF + + + +
Sbjct: 1283 AQGQGPEKVKKTTQV----KDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINAS 1338
Query: 1086 LVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPP 1145
+VR+K+LFPGQPA E+G I GD+IL VNG S +GL QEV+ LRG EV LLLCRPP
Sbjct: 1339 IVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPP 1398
Query: 1146 PGALPELEQEWQTPELS-------ADKEFTRATCTDSCTSPILDQ----------EDSWR 1188
PG LPE++ TP S + K+ ++ +C + TS ++ S R
Sbjct: 1399 PGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRR 1458
Query: 1189 DSASPDAGEG 1198
DS S +G G
Sbjct: 1459 DSYSDSSGSG 1468
Score = 108 bits (271), Expect = 3e-23
Identities = 76/208 (36%), Positives = 115/208 (55%), Gaps = 33/208 (15%)
Query: 15 VTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSS------DYVVCPWSALLSAAG 68
V+LA AL+VRG L EEEIW++L +AE L E R S +++ PWS LL +G
Sbjct: 3 VSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSG 62
Query: 69 SLSFQGR-VSHIEAAPFKAPELLQGQS----------------------EDEQPDASQPL 105
S+SF +S+ + F APE+LQ QS D + SQP+
Sbjct: 63 SVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPI 122
Query: 106 QLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTI 165
+L + L+SILL MCED + R ++++VL+AC H + + AP+ +++ LV LVLG +
Sbjct: 123 KLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNC--APSFSYVKHLVKLVLGNL 180
Query: 166 SEVEKRVVEESSSVQQNRSYLLRKRLRG 193
S ++ + +S + +RS +R RLRG
Sbjct: 181 SGTDQ--LSCNSEQKPDRSQAIRDRLRG 206
Score = 60.8 bits (146), Expect = 8e-09
Identities = 73/277 (26%), Positives = 110/277 (39%), Gaps = 50/277 (18%)
Query: 925 EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984
E+ + E G+LGF+VT G N + G YV ++ PA +G++ GDRL++V+
Sbjct: 1595 ELLITLIKSEKGSLGFTVTKG-NQRI---GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDT 1649
Query: 985 ILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRP 1044
+ +TH AV L + RLV+ R V LP P
Sbjct: 1650 DVTNMTHTDAVNLLRAASKTVRLVIGR-------------------------VLELPRIP 1684
Query: 1045 SSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS--DLVRIKRLFPGQPAEENG 1102
+ D + L N LGFS C S +V I + P A G
Sbjct: 1685 MLPHLLPD-----ITLTCNKEELGFSL-------CGGHDSLYQVVYISDINPRSVAAIEG 1732
Query: 1103 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELS 1162
+ D+I VNG ST+G+ +EV L + + L R +P ++ +S
Sbjct: 1733 NLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRS----AVS 1788
Query: 1163 ADK--EFTRATCTDSCTSPILDQEDSWRDSASPDAGE 1197
A K + + SC+ P L DS+ A + E
Sbjct: 1789 APKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE 1825
Score = 32.7 bits (73), Expect = 2.3
Identities = 18/84 (21%), Positives = 39/84 (46%), Gaps = 5/84 (5%)
Query: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
+TL + GF + +G G ++ +I PA+ +KPG +++ +N +
Sbjct: 1598 ITLIKSEKGSLGFTVTKGNQR----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1652
Query: 814 GFTFNMAVRMIQNSPDNIELIISQ 837
T AV +++ + + L+I +
Sbjct: 1653 NMTHTDAVNLLRAASKTVRLVIGR 1676
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 367 bits (943), Expect = e-101
Identities = 229/626 (36%), Positives = 348/626 (55%), Gaps = 75/626 (11%)
Query: 286 FSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAV 345
F PEF+ + E ++L LP S++TKKGK+ R + ++LLNGQ LE+ CD ++ V
Sbjct: 538 FFGPEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDV 597
Query: 346 FNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNT--FTLF 403
F+ V + L E F LA +K E+FF+D + +L K+APEGW+E+P+K + T FTLF
Sbjct: 598 FDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLF 657
Query: 404 LRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKE 463
RIKFF+ L+QH+LT HQ+YLQLRKDILEER++C++E L L LALQAE+G+Y E
Sbjct: 658 FRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPE 717
Query: 464 QVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEY 523
V YF +E Y+PA ++E++ ++ E+ ++H ++ EL+FL+V Q+L EY
Sbjct: 718 -VHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEY 776
Query: 524 GVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTI 583
GV H+V EK + + + LG+C+KGV+V+EV N R +LRF WRET KIS +KK T+
Sbjct: 777 GVHFHRVHPEK-KSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITL 835
Query: 584 TSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSHVL--------------- 628
++ G KH F TD++K +YLL LCS QH F QM + Q +
Sbjct: 836 QNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQA 895
Query: 629 -----FDHDKFVQMANL--SPAHQARSKPLI----WIQRLSCSENELFVSRLQGAAGGL- 676
F+ + + +L S ++ +PL ++RLSCSE L+ LQ ++
Sbjct: 896 ESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAEILKRLSCSELSLY-QPLQNSSKEKN 954
Query: 677 -----------LSTSMDNF--------------NVDGSKEAGAEGIGR----SPCTGREQ 707
+S S + N++ + AE +G+ + E
Sbjct: 955 DKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAES 1014
Query: 708 LKSACVIQKPMTWDSLSGPPVQSMHAGSKN--------------NRRKSFIAEPGREIVR 753
L + + SL+ P + H + ++R S ++ P REI
Sbjct: 1015 LAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITL 1074
Query: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
V LK+D G GF I GE G+ D GIFISS+ PGGPA+ +KPG +++++N +SLE
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1134
Query: 814 GFTFNMAVRMIQNSPDNIELIISQSK 839
G + + A+ ++QN+P+++ L+ISQ K
Sbjct: 1135 GVSHHAAIEILQNAPEDVTLVISQPK 1160
Score = 220 bits (561), Expect = 6e-57
Identities = 144/381 (37%), Positives = 205/381 (53%), Gaps = 48/381 (12%)
Query: 847 DEEKNSTANSGVSSTDILSFGYQGSL----LSHTQDQDRNTEELDMAGVQSLVPRLRHQL 902
D ++ T G+S D+ + +G +++ QD T + + + + ++ +
Sbjct: 1279 DSNQSKTKKPGIS--DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKT 1336
Query: 903 SFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVP 962
SS PP P G+I+ VEL K D +LG SVTGG+NTSV +GGIYVK+++P
Sbjct: 1337 F--------SSSPPKP-----GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIP 1383
Query: 963 GGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLER--------RVP 1014
G A +G+I +GDR+L V+GV L G THKQAV+ L GQV L+LE+ VP
Sbjct: 1384 QGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 1443
Query: 1015 RSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQM 1074
+ Q S ++ G V T + VT+ FEVKL KN++GLGFSF +
Sbjct: 1444 VTPQCTLSDQNAQGQGPEKVKKTTQV----KDYSFVTEENTFEVKLFKNSSGLGFSFSRE 1499
Query: 1075 EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAP 1134
+ + + +VR+K+LFPGQPA E+G I GD+IL VNG S +GL QEV+ LRG
Sbjct: 1500 DNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTA 1559
Query: 1135 QEVTLLLCRPPPGALPELEQEWQTPELS-------ADKEFTRATCTDSCTSPILDQ---- 1183
EV LLLCRPPPG LPE++ TP S + K+ ++ +C + TS ++
Sbjct: 1560 PEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDK 1619
Query: 1184 ------EDSWRDSASPDAGEG 1198
S RDS S +G G
Sbjct: 1620 SKKQCKSPSRRDSYSDSSGSG 1640
Score = 108 bits (271), Expect = 3e-23
Identities = 76/208 (36%), Positives = 115/208 (55%), Gaps = 33/208 (15%)
Query: 15 VTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSS------DYVVCPWSALLSAAG 68
V+LA AL+VRG L EEEIW++L +AE L E R S +++ PWS LL +G
Sbjct: 3 VSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSG 62
Query: 69 SLSFQGR-VSHIEAAPFKAPELLQGQS----------------------EDEQPDASQPL 105
S+SF +S+ + F APE+LQ QS D + SQP+
Sbjct: 63 SVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPI 122
Query: 106 QLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTI 165
+L + L+SILL MCED + R ++++VL+AC H + + AP+ +++ LV LVLG +
Sbjct: 123 KLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNC--APSFSYVKHLVKLVLGNL 180
Query: 166 SEVEKRVVEESSSVQQNRSYLLRKRLRG 193
S ++ + +S + +RS +R RLRG
Sbjct: 181 SGTDQ--LSCNSEQKPDRSQAIRDRLRG 206
Score = 74.3 bits (181), Expect = 7e-13
Identities = 75/294 (25%), Positives = 127/294 (43%), Gaps = 56/294 (19%)
Query: 730 SMHAGSKNNRRKSFIAEPGR--EIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSII 787
S++ +K N K+F + P + +I V L ++ + G + G + GI++ ++I
Sbjct: 1325 SVNTSNKMNF-KTFSSSPPKPGDIFEVELAKNDN-SLGISVTGGVNTSVRHGGIYVKAVI 1382
Query: 788 PGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPD 847
P G AE I G ++LA+N +SLEG T AV ++N+ + L++ + G +P
Sbjct: 1383 PQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK-----GQSP- 1436
Query: 848 EEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPL 907
T+ V T + Q + + + T+ D SF
Sbjct: 1437 -----TSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKD--------------YSF--- 1474
Query: 908 KGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFS-------VTGGINTSVPYGGIYVKSI 960
++ + V+L K LGFS + IN S+ + VK +
Sbjct: 1475 -------------VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASI----VRVKKL 1517
Query: 961 VPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
PG PAA+ G+I GD +L+V+G L GL+ ++ + L G L+L R P
Sbjct: 1518 FPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPP 1571
Score = 60.8 bits (146), Expect = 8e-09
Identities = 73/277 (26%), Positives = 110/277 (39%), Gaps = 50/277 (18%)
Query: 925 EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984
E+ + E G+LGF+VT G N + G YV ++ PA +G++ GDRL++V+
Sbjct: 1767 ELLITLIKSEKGSLGFTVTKG-NQRI---GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDT 1821
Query: 985 ILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRP 1044
+ +TH AV L + RLV+ R V LP P
Sbjct: 1822 DVTNMTHTDAVNLLRAASKTVRLVIGR-------------------------VLELPRIP 1856
Query: 1045 SSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS--DLVRIKRLFPGQPAEENG 1102
+ D + L N LGFS C S +V I + P A G
Sbjct: 1857 MLPHLLPD-----ITLTCNKEELGFSL-------CGGHDSLYQVVYISDINPRSVAAIEG 1904
Query: 1103 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELS 1162
+ D+I VNG ST+G+ +EV L + + L R +P ++ +S
Sbjct: 1905 NLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRS----AVS 1960
Query: 1163 ADK--EFTRATCTDSCTSPILDQEDSWRDSASPDAGE 1197
A K + + SC+ P L DS+ A + E
Sbjct: 1961 APKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE 1997
Score = 57.0 bits (136), Expect = 1e-07
Identities = 42/132 (31%), Positives = 69/132 (52%), Gaps = 6/132 (4%)
Query: 1015 RSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNAN-GLGFSFVQ 1073
RS ++ +DS E + V + + S VS + V LKK+A GLGF +
Sbjct: 1032 RSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIG 1091
Query: 1074 MEKESCSHLKSDL-VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRG 1132
EK + DL + I + PG PA+ +G + GD +++VN S EG+ + +L+
Sbjct: 1092 GEKMG----RLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQN 1147
Query: 1133 APQEVTLLLCRP 1144
AP++VTL++ +P
Sbjct: 1148 APEDVTLVISQP 1159
Score = 55.1 bits (131), Expect = 4e-07
Identities = 42/142 (29%), Positives = 67/142 (47%), Gaps = 10/142 (7%)
Query: 871 SLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVE 930
S+ S + +R E D + ++ P + L L + + S P EI V
Sbjct: 1026 SVASLNRSPERRKHESDSSSIED--PGQAYVLDVLHKRWSIVSSPER-------EITLVN 1076
Query: 931 LVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGL 989
L K+ LGF + GG GI++ S+ PGGPA +G + GDRL+ V+ V L G+
Sbjct: 1077 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1136
Query: 990 THKQAVQCLTGPGQVARLVLER 1011
+H A++ L + LV+ +
Sbjct: 1137 SHHAAIEILQNAPEDVTLVISQ 1158
Score = 32.7 bits (73), Expect = 2.3
Identities = 18/84 (21%), Positives = 39/84 (46%), Gaps = 5/84 (5%)
Query: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
+TL + GF + +G G ++ +I PA+ +KPG +++ +N +
Sbjct: 1770 ITLIKSEKGSLGFTVTKGNQR----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1824
Query: 814 GFTFNMAVRMIQNSPDNIELIISQ 837
T AV +++ + + L+I +
Sbjct: 1825 NMTHTDAVNLLRAASKTVRLVIGR 1848
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 297 bits (761), Expect = 4e-80
Identities = 157/340 (46%), Positives = 225/340 (66%), Gaps = 4/340 (1%)
Query: 286 FSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAV 345
F PEF+ + E ++L LP S++TKKGK+ R + ++LLNGQ LE+ CD ++ V
Sbjct: 538 FFGPEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDV 597
Query: 346 FNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNT--FTLF 403
F+ V + L E F LA +K E+FF+D + +L K+APEGW+E+P+K + T FTLF
Sbjct: 598 FDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLF 657
Query: 404 LRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKE 463
RIKFF+ L+QH+LT HQ+YLQLRKDILEER++C++E L L LALQAE+G+Y E
Sbjct: 658 FRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPE 717
Query: 464 QVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEY 523
V YF +E Y+PA ++E++ ++ E+ ++H ++ EL+FL+V Q+L EY
Sbjct: 718 -VHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEY 776
Query: 524 GVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTI 583
GV H+V EK + + + LG+C+KGV+V+EV N R +LRF WRET KIS +KK T+
Sbjct: 777 GVHFHRVHPEK-KSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITL 835
Query: 584 TSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQ 623
++ G KH F TD++K +YLL LCS QH F QM + Q
Sbjct: 836 QNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQ 875
Score = 214 bits (545), Expect = 4e-55
Identities = 144/386 (37%), Positives = 205/386 (53%), Gaps = 53/386 (13%)
Query: 847 DEEKNSTANSGVSSTDILSFGYQGSL----LSHTQDQDRNTEELDMAGVQSLVPRLRHQL 902
D ++ T G+S D+ + +G +++ QD T + + + + ++ +
Sbjct: 1298 DSNQSKTKKPGIS--DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKT 1355
Query: 903 SFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVT-----GGINTSVPYGGIYV 957
SS PP P G+I+ VEL K D +LG SVT GG+NTSV +GGIYV
Sbjct: 1356 F--------SSSPPKP-----GDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYV 1402
Query: 958 KSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLER------ 1011
K+++P G A +G+I +GDR+L V+GV L G THKQAV+ L GQV L+LE+
Sbjct: 1403 KAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTS 1462
Query: 1012 --RVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGF 1069
VP + Q S ++ G V T + VT+ FEVKL KN++GLGF
Sbjct: 1463 KEHVPVTPQCTLSDQNAQGQGPEKVKKTTQV----KDYSFVTEENTFEVKLFKNSSGLGF 1518
Query: 1070 SFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHL 1129
SF + + + + +VR+K+LFPGQPA E+G I GD+IL VNG S +GL QEV+
Sbjct: 1519 SFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISA 1578
Query: 1130 LRGAPQEVTLLLCRPPPGALPELEQEWQTPELS-------ADKEFTRATCTDSCTSPILD 1182
LRG EV LLLCRPPPG LPE++ TP S + K+ ++ +C + TS +
Sbjct: 1579 LRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDEN 1638
Query: 1183 Q----------EDSWRDSASPDAGEG 1198
+ S RDS S +G G
Sbjct: 1639 EMSDKSKKQCKSPSRRDSYSDSSGSG 1664
Score = 108 bits (271), Expect = 3e-23
Identities = 76/208 (36%), Positives = 115/208 (55%), Gaps = 33/208 (15%)
Query: 15 VTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSS------DYVVCPWSALLSAAG 68
V+LA AL+VRG L EEEIW++L +AE L E R S +++ PWS LL +G
Sbjct: 3 VSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSG 62
Query: 69 SLSFQGR-VSHIEAAPFKAPELLQGQS----------------------EDEQPDASQPL 105
S+SF +S+ + F APE+LQ QS D + SQP+
Sbjct: 63 SVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPI 122
Query: 106 QLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTI 165
+L + L+SILL MCED + R ++++VL+AC H + + AP+ +++ LV LVLG +
Sbjct: 123 KLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNC--APSFSYVKHLVKLVLGNL 180
Query: 166 SEVEKRVVEESSSVQQNRSYLLRKRLRG 193
S ++ + +S + +RS +R RLRG
Sbjct: 181 SGTDQ--LSCNSEQKPDRSQAIRDRLRG 206
Score = 98.6 bits (244), Expect = 3e-20
Identities = 46/102 (45%), Positives = 71/102 (69%)
Query: 738 NRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKT 797
++R S ++ P REI V LK+D G GF I GE G+ D GIFISS+ PGGPA+
Sbjct: 1078 HKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGC 1137
Query: 798 IKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSK 839
+KPG +++++N +SLEG + + A+ ++QN+P+++ L+ISQ K
Sbjct: 1138 LKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK 1179
Score = 70.9 bits (172), Expect = 8e-12
Identities = 77/298 (25%), Positives = 126/298 (42%), Gaps = 59/298 (19%)
Query: 730 SMHAGSKNNRRKSFIAEPGR--EIVRVTL-KRDPHRGFGFVI---NEGEYSGQADPGIFI 783
S++ +K N K+F + P + +I V L K D G + G + GI++
Sbjct: 1344 SVNTSNKMNF-KTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYV 1402
Query: 784 SSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGG 843
++IP G AE I G ++LA+N +SLEG T AV ++N+ + L++ + G
Sbjct: 1403 KAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK-----G 1457
Query: 844 NNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLS 903
+P T+ V T + Q + + + T+ D S
Sbjct: 1458 QSP------TSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKD--------------YS 1497
Query: 904 FLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFS-------VTGGINTSVPYGGIY 956
F ++ + V+L K LGFS + IN S+ +
Sbjct: 1498 F----------------VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASI----VR 1537
Query: 957 VKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
VK + PG PAA+ G+I GD +L+V+G L GL+ ++ + L G L+L R P
Sbjct: 1538 VKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPP 1595
Score = 60.8 bits (146), Expect = 8e-09
Identities = 73/277 (26%), Positives = 110/277 (39%), Gaps = 50/277 (18%)
Query: 925 EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984
E+ + E G+LGF+VT G N + G YV ++ PA +G++ GDRL++V+
Sbjct: 1791 ELLITLIKSEKGSLGFTVTKG-NQRI---GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDT 1845
Query: 985 ILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRP 1044
+ +TH AV L + RLV+ R V LP P
Sbjct: 1846 DVTNMTHTDAVNLLRAASKTVRLVIGR-------------------------VLELPRIP 1880
Query: 1045 SSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS--DLVRIKRLFPGQPAEENG 1102
+ D + L N LGFS C S +V I + P A G
Sbjct: 1881 MLPHLLPD-----ITLTCNKEELGFSL-------CGGHDSLYQVVYISDINPRSVAAIEG 1928
Query: 1103 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELS 1162
+ D+I VNG ST+G+ +EV L + + L R +P ++ +S
Sbjct: 1929 NLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRS----AVS 1984
Query: 1163 ADK--EFTRATCTDSCTSPILDQEDSWRDSASPDAGE 1197
A K + + SC+ P L DS+ A + E
Sbjct: 1985 APKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE 2021
Score = 56.2 bits (134), Expect = 2e-07
Identities = 36/101 (35%), Positives = 58/101 (57%), Gaps = 9/101 (8%)
Query: 1049 SVTDGPKFE---VKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGA 1103
S+ P+ E V LKK+A GLGF + EK + DL + I + PG PA+ +G
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMG----RLDLGIFISSVAPGGPADLDGC 1137
Query: 1104 IAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRP 1144
+ GD +++VN S EG+ + +L+ AP++VTL++ +P
Sbjct: 1138 LKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQP 1178
Score = 54.3 bits (129), Expect = 7e-07
Identities = 32/88 (36%), Positives = 48/88 (54%), Gaps = 1/88 (1%)
Query: 925 EIYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDG 983
EI V L K+ LGF + GG GI++ S+ PGGPA +G + GDRL+ V+
Sbjct: 1090 EITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNS 1149
Query: 984 VILCGLTHKQAVQCLTGPGQVARLVLER 1011
V L G++H A++ L + LV+ +
Sbjct: 1150 VSLEGVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 32.7 bits (73), Expect = 2.3
Identities = 18/84 (21%), Positives = 39/84 (46%), Gaps = 5/84 (5%)
Query: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
+TL + GF + +G G ++ +I PA+ +KPG +++ +N +
Sbjct: 1794 ITLIKSEKGSLGFTVTKGNQR----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1848
Query: 814 GFTFNMAVRMIQNSPDNIELIISQ 837
T AV +++ + + L+I +
Sbjct: 1849 NMTHTDAVNLLRAASKTVRLVIGR 1872
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 297 bits (761), Expect = 4e-80
Identities = 157/340 (46%), Positives = 225/340 (66%), Gaps = 4/340 (1%)
Query: 286 FSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAV 345
F PEF+ + E ++L LP S++TKKGK+ R + ++LLNGQ LE+ CD ++ V
Sbjct: 538 FFGPEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDV 597
Query: 346 FNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNT--FTLF 403
F+ V + L E F LA +K E+FF+D + +L K+APEGW+E+P+K + T FTLF
Sbjct: 598 FDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLF 657
Query: 404 LRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKE 463
RIKFF+ L+QH+LT HQ+YLQLRKDILEER++C++E L L LALQAE+G+Y E
Sbjct: 658 FRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPE 717
Query: 464 QVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEY 523
V YF +E Y+PA ++E++ ++ E+ ++H ++ EL+FL+V Q+L EY
Sbjct: 718 -VHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEY 776
Query: 524 GVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTI 583
GV H+V EK + + + LG+C+KGV+V+EV N R +LRF WRET KIS +KK T+
Sbjct: 777 GVHFHRVHPEK-KSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITL 835
Query: 584 TSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQ 623
++ G KH F TD++K +YLL LCS QH F QM + Q
Sbjct: 836 QNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQ 875
Score = 220 bits (561), Expect = 6e-57
Identities = 144/381 (37%), Positives = 205/381 (53%), Gaps = 48/381 (12%)
Query: 847 DEEKNSTANSGVSSTDILSFGYQGSL----LSHTQDQDRNTEELDMAGVQSLVPRLRHQL 902
D ++ T G+S D+ + +G +++ QD T + + + + ++ +
Sbjct: 1298 DSNQSKTKKPGIS--DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKT 1355
Query: 903 SFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVP 962
SS PP P G+I+ VEL K D +LG SVTGG+NTSV +GGIYVK+++P
Sbjct: 1356 F--------SSSPPKP-----GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIP 1402
Query: 963 GGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLER--------RVP 1014
G A +G+I +GDR+L V+GV L G THKQAV+ L GQV L+LE+ VP
Sbjct: 1403 QGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 1462
Query: 1015 RSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQM 1074
+ Q S ++ G V T + VT+ FEVKL KN++GLGFSF +
Sbjct: 1463 VTPQCTLSDQNAQGQGPEKVKKTTQV----KDYSFVTEENTFEVKLFKNSSGLGFSFSRE 1518
Query: 1075 EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAP 1134
+ + + +VR+K+LFPGQPA E+G I GD+IL VNG S +GL QEV+ LRG
Sbjct: 1519 DNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTA 1578
Query: 1135 QEVTLLLCRPPPGALPELEQEWQTPELS-------ADKEFTRATCTDSCTSPILDQ---- 1183
EV LLLCRPPPG LPE++ TP S + K+ ++ +C + TS ++
Sbjct: 1579 PEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDK 1638
Query: 1184 ------EDSWRDSASPDAGEG 1198
S RDS S +G G
Sbjct: 1639 SKKQCKSPSRRDSYSDSSGSG 1659
Score = 108 bits (271), Expect = 3e-23
Identities = 76/208 (36%), Positives = 115/208 (55%), Gaps = 33/208 (15%)
Query: 15 VTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSS------DYVVCPWSALLSAAG 68
V+LA AL+VRG L EEEIW++L +AE L E R S +++ PWS LL +G
Sbjct: 3 VSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSG 62
Query: 69 SLSFQGR-VSHIEAAPFKAPELLQGQS----------------------EDEQPDASQPL 105
S+SF +S+ + F APE+LQ QS D + SQP+
Sbjct: 63 SVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPI 122
Query: 106 QLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTI 165
+L + L+SILL MCED + R ++++VL+AC H + + AP+ +++ LV LVLG +
Sbjct: 123 KLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNC--APSFSYVKHLVKLVLGNL 180
Query: 166 SEVEKRVVEESSSVQQNRSYLLRKRLRG 193
S ++ + +S + +RS +R RLRG
Sbjct: 181 SGTDQ--LSCNSEQKPDRSQAIRDRLRG 206
Score = 98.6 bits (244), Expect = 3e-20
Identities = 46/102 (45%), Positives = 71/102 (69%)
Query: 738 NRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKT 797
++R S ++ P REI V LK+D G GF I GE G+ D GIFISS+ PGGPA+
Sbjct: 1078 HKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGC 1137
Query: 798 IKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSK 839
+KPG +++++N +SLEG + + A+ ++QN+P+++ L+ISQ K
Sbjct: 1138 LKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK 1179
Score = 74.3 bits (181), Expect = 7e-13
Identities = 75/294 (25%), Positives = 127/294 (43%), Gaps = 56/294 (19%)
Query: 730 SMHAGSKNNRRKSFIAEPGR--EIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSII 787
S++ +K N K+F + P + +I V L ++ + G + G + GI++ ++I
Sbjct: 1344 SVNTSNKMNF-KTFSSSPPKPGDIFEVELAKNDN-SLGISVTGGVNTSVRHGGIYVKAVI 1401
Query: 788 PGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPD 847
P G AE I G ++LA+N +SLEG T AV ++N+ + L++ + G +P
Sbjct: 1402 PQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK-----GQSP- 1455
Query: 848 EEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPL 907
T+ V T + Q + + + T+ D SF
Sbjct: 1456 -----TSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKD--------------YSF--- 1493
Query: 908 KGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFS-------VTGGINTSVPYGGIYVKSI 960
++ + V+L K LGFS + IN S+ + VK +
Sbjct: 1494 -------------VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASI----VRVKKL 1536
Query: 961 VPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
PG PAA+ G+I GD +L+V+G L GL+ ++ + L G L+L R P
Sbjct: 1537 FPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPP 1590
Score = 60.8 bits (146), Expect = 8e-09
Identities = 73/277 (26%), Positives = 110/277 (39%), Gaps = 50/277 (18%)
Query: 925 EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984
E+ + E G+LGF+VT G N + G YV ++ PA +G++ GDRL++V+
Sbjct: 1786 ELLITLIKSEKGSLGFTVTKG-NQRI---GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDT 1840
Query: 985 ILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRP 1044
+ +TH AV L + RLV+ R V LP P
Sbjct: 1841 DVTNMTHTDAVNLLRAASKTVRLVIGR-------------------------VLELPRIP 1875
Query: 1045 SSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS--DLVRIKRLFPGQPAEENG 1102
+ D + L N LGFS C S +V I + P A G
Sbjct: 1876 MLPHLLPD-----ITLTCNKEELGFSL-------CGGHDSLYQVVYISDINPRSVAAIEG 1923
Query: 1103 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELS 1162
+ D+I VNG ST+G+ +EV L + + L R +P ++ +S
Sbjct: 1924 NLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRS----AVS 1979
Query: 1163 ADK--EFTRATCTDSCTSPILDQEDSWRDSASPDAGE 1197
A K + + SC+ P L DS+ A + E
Sbjct: 1980 APKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE 2016
Score = 56.2 bits (134), Expect = 2e-07
Identities = 36/101 (35%), Positives = 58/101 (57%), Gaps = 9/101 (8%)
Query: 1049 SVTDGPKFE---VKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGA 1103
S+ P+ E V LKK+A GLGF + EK + DL + I + PG PA+ +G
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMG----RLDLGIFISSVAPGGPADLDGC 1137
Query: 1104 IAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRP 1144
+ GD +++VN S EG+ + +L+ AP++VTL++ +P
Sbjct: 1138 LKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQP 1178
Score = 54.3 bits (129), Expect = 7e-07
Identities = 32/88 (36%), Positives = 48/88 (54%), Gaps = 1/88 (1%)
Query: 925 EIYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDG 983
EI V L K+ LGF + GG GI++ S+ PGGPA +G + GDRL+ V+
Sbjct: 1090 EITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNS 1149
Query: 984 VILCGLTHKQAVQCLTGPGQVARLVLER 1011
V L G++H A++ L + LV+ +
Sbjct: 1150 VSLEGVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 32.7 bits (73), Expect = 2.3
Identities = 18/84 (21%), Positives = 39/84 (46%), Gaps = 5/84 (5%)
Query: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
+TL + GF + +G G ++ +I PA+ +KPG +++ +N +
Sbjct: 1789 ITLIKSEKGSLGFTVTKGNQR----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1843
Query: 814 GFTFNMAVRMIQNSPDNIELIISQ 837
T AV +++ + + L+I +
Sbjct: 1844 NMTHTDAVNLLRAASKTVRLVIGR 1867
>gi|109715866 FERM domain containing 6 [Homo sapiens]
Length = 614
Score = 125 bits (313), Expect = 3e-28
Identities = 73/300 (24%), Positives = 145/300 (48%), Gaps = 8/300 (2%)
Query: 320 RDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETR 379
R +C+ L N + L + +V+ + V L++ FGL+ +++ E +++ +
Sbjct: 16 RSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQK 75
Query: 380 LCKIAPEGWREQPQKTSMNTF----TLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILE 435
L K P+ W+++ K ++ F + R++++V + L+ R+ +Y LRK +L
Sbjct: 76 LYKYCPKEWKKEASK-GIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLH 134
Query: 436 ERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVS 495
+ EE L ALQA+ GN+ + + K YF E Y P+ ++ + + +
Sbjct: 135 SQCVLREEAYFLLAAFALQADLGNFKRNKHYGK-YFEPEAYFPSWVVSKRGKDYILKHIP 193
Query: 496 EMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEV 555
MH+ AL +A LK+++ +L + V ++++ +KR E + LG+ +G+ +++
Sbjct: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
Query: 556 KNNSRIAMLRFQWRETGKISTYQKKFTITSS--VTGKKHTFVTDSAKTSKYLLDLCSAQH 613
+ + + F W GK+ KKF I + +K + T S++LL L S H
Sbjct: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSH 313
>gi|22748721 FERM domain containing 6 [Homo sapiens]
Length = 614
Score = 125 bits (313), Expect = 3e-28
Identities = 73/300 (24%), Positives = 145/300 (48%), Gaps = 8/300 (2%)
Query: 320 RDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETR 379
R +C+ L N + L + +V+ + V L++ FGL+ +++ E +++ +
Sbjct: 16 RSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQK 75
Query: 380 LCKIAPEGWREQPQKTSMNTF----TLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILE 435
L K P+ W+++ K ++ F + R++++V + L+ R+ +Y LRK +L
Sbjct: 76 LYKYCPKEWKKEASK-GIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLH 134
Query: 436 ERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVS 495
+ EE L ALQA+ GN+ + + K YF E Y P+ ++ + + +
Sbjct: 135 SQCVLREEAYFLLAAFALQADLGNFKRNKHYGK-YFEPEAYFPSWVVSKRGKDYILKHIP 193
Query: 496 EMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEV 555
MH+ AL +A LK+++ +L + V ++++ +KR E + LG+ +G+ +++
Sbjct: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
Query: 556 KNNSRIAMLRFQWRETGKISTYQKKFTITSS--VTGKKHTFVTDSAKTSKYLLDLCSAQH 613
+ + + F W GK+ KKF I + +K + T S++LL L S H
Sbjct: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSH 313
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 121 bits (303), Expect = 5e-27
Identities = 89/318 (27%), Positives = 156/318 (49%), Gaps = 23/318 (7%)
Query: 304 LPGSVVTKKGKSYLALRDLCVV----LLNGQHLEVKCDVESTVGAVFNAVTSFANLEELT 359
LP + K+ + Y C+V LLN + +E VEST AV L E+T
Sbjct: 3 LPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVT 62
Query: 360 YFGLAYM-KSKEFFFLDSETRLCKIAPEGWREQPQKTSMNTFTLFLRIKFFVSHYGLLQH 418
YF L Y K + ++D E L ++Q K ++ T++ + F+V LQ
Sbjct: 63 YFSLWYYNKQNQRRWVDLEKPL--------KKQLDKYALEP-TVYFGVVFYVPSVSQLQQ 113
Query: 419 SLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIP 478
+TR+Q+YLQL+KDILE + C E +QL LA+QA+FG++ +Q ES+ + P
Sbjct: 114 EITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDF--DQYESQDFLQKFALFP 171
Query: 479 ASLIERMTALRVQVE-VSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRP 537
++ L + V+ +H+ L DAE+ +++ +++ YG + + K
Sbjct: 172 VGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYG---EESYPAKDSQ 228
Query: 538 EEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTITSSVTGKKHTFVTD 597
++++G C +G+ VK+ + + F+W + +S + F + + + F T+
Sbjct: 229 GSDISIGACLEGIF---VKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTE 285
Query: 598 SAKTSKYLLDLCSAQHGF 615
+T+KY+ LC A+H F
Sbjct: 286 DMETAKYIWRLCVARHKF 303
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
Length = 1187
Score = 113 bits (282), Expect = 1e-24
Identities = 90/326 (27%), Positives = 154/326 (47%), Gaps = 33/326 (10%)
Query: 304 LPGSVVTKKGKSYLALRDLCVV----LLNGQHLEVKCDVESTVGAVFNAVTSFANLEELT 359
+P + ++ + Y L C V LL+ +E VEST AV L E
Sbjct: 1 MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH 60
Query: 360 YFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNTFT----LFLRIKFFVSHYGL 415
YFGL ++ + + R ++ E+P K ++ F LF + F+V +
Sbjct: 61 YFGLWFLSKSQ------QARWVEL------EKPLKKHLDKFANEPLLFFGVMFYVPNVSW 108
Query: 416 LQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVED 475
LQ TR+Q+YLQ++KD+LE RL C + +++L LA+QA+FG+Y Q +S+ +
Sbjct: 109 LQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDY--NQFDSQDFLREYV 166
Query: 476 YIPASL-IERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEK 534
P L +E + +V++ H+ S + +AEL ++ ++L +G ++F K
Sbjct: 167 LFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFG---QEIFPVK 223
Query: 535 RRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTITSSVTGKKHT- 593
+ LGI G+ V+N + ++W + G I+ K TI + K+ T
Sbjct: 224 DNHGNCVHLGIFFMGIF---VRNRIGRQAVIYRWNDMGNIT--HNKSTILVELINKEETA 278
Query: 594 -FVTDSAKTSKYLLDLCSAQHGFNAQ 618
F TD + +KY+ L + +H F Q
Sbjct: 279 LFHTDDIENAKYISRLFATRHKFYKQ 304
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 106 bits (264), Expect = 2e-22
Identities = 129/458 (28%), Positives = 193/458 (42%), Gaps = 83/458 (18%)
Query: 723 LSGPPVQSMHAGSKNNRRKSFIAEPGR---EIVRVTLKRDPHRGFGFVINEGE----YSG 775
+S P V+ + NN + EP R E + +T+ R G G I G+ Y G
Sbjct: 699 VSAPSVKGVSFDQANN----LLIEPARIEEEELTLTILRQTG-GLGISIAGGKGSTPYKG 753
Query: 776 QADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELII 835
D GIFIS + GPA +A ++ G ++L +N ++L+G + AV ++ + +++ +
Sbjct: 754 D-DEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRV 811
Query: 836 SQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLV 895
+ + V E +N+ + + D S
Sbjct: 812 WRERMV------EPENAVTITPLRPEDDYS------------------------------ 835
Query: 896 PRLRHQLSFLPLKGAGSSCPPSPPEISAGEI---YFVELVKEDGTLGFSVTGGINTSVPY 952
PR R +G G P PPE S G + + L + + LGFS+ GG S PY
Sbjct: 836 PRER--------RGGGLRLPLLPPE-SPGPLRQRHVACLARSERGLGFSIAGG-KGSTPY 885
Query: 953 ----GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLV 1008
GI+V I GG A + G + GDR+L ++GV + H AV LT L+
Sbjct: 886 RAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALL 945
Query: 1009 LERRVPRSTQQCPSANDSMGDERTA-VSLVTALPG-------RPSSCVSVTDG--PKFEV 1058
LER P + S A S+ TA PG PS + +G P E+
Sbjct: 946 LEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEI 1005
Query: 1059 KLKKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 1115
+L + LG S V S SH ++ V I ++ P A +G + GD ILAVNG
Sbjct: 1006 RLPRAGGPLGLSIVGGSDHS-SHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 1116 RSTEGLIFQEVLHLLRGAPQEVTLLLCR-PPPGALPEL 1152
+ QE + L E++LL+ R P P L EL
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLREL 1101
Score = 91.3 bits (225), Expect = 5e-18
Identities = 99/389 (25%), Positives = 161/389 (41%), Gaps = 77/389 (19%)
Query: 762 RGFGFVINEGEYSGQ---ADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFN 818
RG GF I G+ S D GIF+S I GG A +A T++ G ++L++N + + +
Sbjct: 870 RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHD 929
Query: 819 MAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQD 878
AV ++ + I L++ + G G P +S+ + +T ++ G
Sbjct: 930 HAVSLLTAASPTIALLLEREAG-GPLPPSPLPHSSPPTAAVATTSITTATPG-------- 980
Query: 879 QDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTL 938
+ G+ SL P L A + P P E + L + G L
Sbjct: 981 ---------VPGLPSLAPSLL----------AAALEGPYPVE-------EIRLPRAGGPL 1014
Query: 939 GFSVTGGI-NTSVPYG----GIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQ 993
G S+ GG ++S P+G G+++ ++P G AA+ G + GDR+L V+G + TH++
Sbjct: 1015 GLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQE 1073
Query: 994 AVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDG 1053
AV L P L L RR P A PG C+ G
Sbjct: 1074 AVSALLRPCLELSL-LVRRDP------------------------APPGLRELCIQKAPG 1108
Query: 1054 PKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAV 1113
+ + ++ A G + E + I ++ P A +G + G +L V
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEG--------IFISKVSPTGAAGRDGRLRVGLRLLEV 1160
Query: 1114 NGRSTEGLIFQEVLHLLRGAPQEVTLLLC 1142
N +S GL E + LLR +T+L+C
Sbjct: 1161 NQQSLLGLTHGEAVQLLRSVGDTLTVLVC 1189
Score = 81.6 bits (200), Expect = 4e-15
Identities = 86/315 (27%), Positives = 134/315 (42%), Gaps = 31/315 (9%)
Query: 874 SHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVK 933
+ ++++ +TEE D G P ++ +SF ++ P I E+ +++
Sbjct: 680 NRAEEEEASTEEEDKEGAVVSAPSVKG-VSF----DQANNLLIEPARIEEEELTLT-ILR 733
Query: 934 EDGTLGFSVTGGINTSVPYGG----IYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGL 989
+ G LG S+ GG S PY G I++ + GPAA+ G + GD+LL+V+GV L G
Sbjct: 734 QTGGLGISIAGG-KGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGA 791
Query: 990 THKQAVQCLTGPGQVA-------RLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPG 1042
H +AV+ L G G R+V T P + S + R + LP
Sbjct: 792 EHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLP- 850
Query: 1043 RPSSCVSVTDGP---KFEVKLKKNANGLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPA 1098
P S GP + L ++ GLGFS + K S + D + + R+ G A
Sbjct: 851 -PES-----PGPLRQRHVACLARSERGLGFS-IAGGKGSTPYRAGDAGIFVSRIAEGGAA 903
Query: 1099 EENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQT 1158
G + GD +L++NG + LL A + LLL R G LP +
Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSS 963
Query: 1159 PELSADKEFTRATCT 1173
P +A + T T
Sbjct: 964 PPTAAVATTSITTAT 978
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 106 bits (264), Expect = 2e-22
Identities = 129/458 (28%), Positives = 193/458 (42%), Gaps = 83/458 (18%)
Query: 723 LSGPPVQSMHAGSKNNRRKSFIAEPGR---EIVRVTLKRDPHRGFGFVINEGE----YSG 775
+S P V+ + NN + EP R E + +T+ R G G I G+ Y G
Sbjct: 699 VSAPSVKGVSFDQANN----LLIEPARIEEEELTLTILRQTG-GLGISIAGGKGSTPYKG 753
Query: 776 QADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELII 835
D GIFIS + GPA +A ++ G ++L +N ++L+G + AV ++ + +++ +
Sbjct: 754 D-DEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRV 811
Query: 836 SQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLV 895
+ + V E +N+ + + D S
Sbjct: 812 WRERMV------EPENAVTITPLRPEDDYS------------------------------ 835
Query: 896 PRLRHQLSFLPLKGAGSSCPPSPPEISAGEI---YFVELVKEDGTLGFSVTGGINTSVPY 952
PR R +G G P PPE S G + + L + + LGFS+ GG S PY
Sbjct: 836 PRER--------RGGGLRLPLLPPE-SPGPLRQRHVACLARSERGLGFSIAGG-KGSTPY 885
Query: 953 ----GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLV 1008
GI+V I GG A + G + GDR+L ++GV + H AV LT L+
Sbjct: 886 RAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALL 945
Query: 1009 LERRVPRSTQQCPSANDSMGDERTA-VSLVTALPG-------RPSSCVSVTDG--PKFEV 1058
LER P + S A S+ TA PG PS + +G P E+
Sbjct: 946 LEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEI 1005
Query: 1059 KLKKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 1115
+L + LG S V S SH ++ V I ++ P A +G + GD ILAVNG
Sbjct: 1006 RLPRAGGPLGLSIVGGSDHS-SHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 1116 RSTEGLIFQEVLHLLRGAPQEVTLLLCR-PPPGALPEL 1152
+ QE + L E++LL+ R P P L EL
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLREL 1101
Score = 91.3 bits (225), Expect = 5e-18
Identities = 99/389 (25%), Positives = 161/389 (41%), Gaps = 77/389 (19%)
Query: 762 RGFGFVINEGEYSGQ---ADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFN 818
RG GF I G+ S D GIF+S I GG A +A T++ G ++L++N + + +
Sbjct: 870 RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHD 929
Query: 819 MAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQD 878
AV ++ + I L++ + G G P +S+ + +T ++ G
Sbjct: 930 HAVSLLTAASPTIALLLEREAG-GPLPPSPLPHSSPPTAAVATTSITTATPG-------- 980
Query: 879 QDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTL 938
+ G+ SL P L A + P P E + L + G L
Sbjct: 981 ---------VPGLPSLAPSLL----------AAALEGPYPVE-------EIRLPRAGGPL 1014
Query: 939 GFSVTGGI-NTSVPYG----GIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQ 993
G S+ GG ++S P+G G+++ ++P G AA+ G + GDR+L V+G + TH++
Sbjct: 1015 GLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQE 1073
Query: 994 AVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDG 1053
AV L P L L RR P A PG C+ G
Sbjct: 1074 AVSALLRPCLELSL-LVRRDP------------------------APPGLRELCIQKAPG 1108
Query: 1054 PKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAV 1113
+ + ++ A G + E + I ++ P A +G + G +L V
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEG--------IFISKVSPTGAAGRDGRLRVGLRLLEV 1160
Query: 1114 NGRSTEGLIFQEVLHLLRGAPQEVTLLLC 1142
N +S GL E + LLR +T+L+C
Sbjct: 1161 NQQSLLGLTHGEAVQLLRSVGDTLTVLVC 1189
Score = 81.6 bits (200), Expect = 4e-15
Identities = 86/315 (27%), Positives = 134/315 (42%), Gaps = 31/315 (9%)
Query: 874 SHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVK 933
+ ++++ +TEE D G P ++ +SF ++ P I E+ +++
Sbjct: 680 NRAEEEEASTEEEDKEGAVVSAPSVKG-VSF----DQANNLLIEPARIEEEELTLT-ILR 733
Query: 934 EDGTLGFSVTGGINTSVPYGG----IYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGL 989
+ G LG S+ GG S PY G I++ + GPAA+ G + GD+LL+V+GV L G
Sbjct: 734 QTGGLGISIAGG-KGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGA 791
Query: 990 THKQAVQCLTGPGQVA-------RLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPG 1042
H +AV+ L G G R+V T P + S + R + LP
Sbjct: 792 EHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLP- 850
Query: 1043 RPSSCVSVTDGP---KFEVKLKKNANGLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPA 1098
P S GP + L ++ GLGFS + K S + D + + R+ G A
Sbjct: 851 -PES-----PGPLRQRHVACLARSERGLGFS-IAGGKGSTPYRAGDAGIFVSRIAEGGAA 903
Query: 1099 EENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQT 1158
G + GD +L++NG + LL A + LLL R G LP +
Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSS 963
Query: 1159 PELSADKEFTRATCT 1173
P +A + T T
Sbjct: 964 PPTAAVATTSITTAT 978
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 105 bits (262), Expect = 3e-22
Identities = 84/284 (29%), Positives = 134/284 (47%), Gaps = 35/284 (12%)
Query: 339 ESTVGAV-FNAVTSFANLEELTYFGLAYM-KSKEFFFLDSETRLCKIAPEGWREQPQKTS 396
+ST G+V + V NL E+ YFGL Y +S + ++LD L + K
Sbjct: 34 KSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAE----------HKEL 83
Query: 397 MNT---FTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLAL 453
+NT +TL+ IKF+ L+ +TR+QF+LQ+++D+L+ RL C QLG A+
Sbjct: 84 INTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAI 143
Query: 454 QAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKF 513
Q+E G+Y PY H Y+ ++ + +H+ +AEL +
Sbjct: 144 QSELGDY-------DPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSEAELNY 196
Query: 514 LRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGK 573
LR + L YGV +H V+ E + E LG+ GV+VY KN ++ ++ W K
Sbjct: 197 LRTAKSLEMYGVDLHPVYGENK---SEYFLGLTPVGVVVY--KNKKQVG--KYFWPRITK 249
Query: 574 ISTYQKKFTITSSVTGK----KHTFVTDSAKTSKYLLDLCSAQH 613
+ + +F + V GK F +KT+ L CS +H
Sbjct: 250 VHFKETQFEL--RVLGKDCNETSFFFEARSKTACKHLWKCSVEH 291
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 100 bits (248), Expect = 1e-20
Identities = 81/289 (28%), Positives = 128/289 (44%), Gaps = 23/289 (7%)
Query: 332 LEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEF---FFLDSETRLCKIAPEGW 388
LE +T +F+ V L E+ YFGL Y+ +K F LD + ++ E
Sbjct: 16 LEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKE-- 73
Query: 389 REQPQKTSMNTFTLFLRIKFFVSHYGL-LQHSLTRHQFYLQLRKDILEERLYCNEEILLQ 447
N R KF+ L +T+ F+LQ+++ IL + +YC E +
Sbjct: 74 ---------NPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVL 124
Query: 448 LGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVE--VSEMHRLSSALW 505
LG A+QA+FG+Y KE V Y E IP ++++ R Q E + H +
Sbjct: 125 LGSYAVQAKFGDYNKE-VHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGML 183
Query: 506 GEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLR 565
++A L++L++ Q L YG+ F K + ++ LG+ A G+ +YE K++ +
Sbjct: 184 KDNAMLEYLKIAQDLEMYGI---NYFEIKNKKGTDLWLGVDALGLNIYE-KDDKLTPKIG 239
Query: 566 FQWRETGKISTYQKKFTITS-SVTGKKHTFVTDSAKTSKYLLDLCSAQH 613
F W E IS KKF I F + +K +L LC H
Sbjct: 240 FPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNH 288
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 100 bits (248), Expect = 1e-20
Identities = 81/289 (28%), Positives = 128/289 (44%), Gaps = 23/289 (7%)
Query: 332 LEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEF---FFLDSETRLCKIAPEGW 388
LE +T +F+ V L E+ YFGL Y+ +K F LD + ++ E
Sbjct: 16 LEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKE-- 73
Query: 389 REQPQKTSMNTFTLFLRIKFFVSHYGL-LQHSLTRHQFYLQLRKDILEERLYCNEEILLQ 447
N R KF+ L +T+ F+LQ+++ IL + +YC E +
Sbjct: 74 ---------NPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVL 124
Query: 448 LGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVE--VSEMHRLSSALW 505
LG A+QA+FG+Y KE V Y E IP ++++ R Q E + H +
Sbjct: 125 LGSYAVQAKFGDYNKE-VHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGML 183
Query: 506 GEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLR 565
++A L++L++ Q L YG+ F K + ++ LG+ A G+ +YE K++ +
Sbjct: 184 KDNAMLEYLKIAQDLEMYGI---NYFEIKNKKGTDLWLGVDALGLNIYE-KDDKLTPKIG 239
Query: 566 FQWRETGKISTYQKKFTITS-SVTGKKHTFVTDSAKTSKYLLDLCSAQH 613
F W E IS KKF I F + +K +L LC H
Sbjct: 240 FPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNH 288
>gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens]
Length = 549
Score = 99.8 bits (247), Expect = 2e-20
Identities = 60/240 (25%), Positives = 117/240 (48%), Gaps = 4/240 (1%)
Query: 320 RDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETR 379
RD+ V+L + + L + V++T +F V + A++ + +FGL +++ E+ F+D E +
Sbjct: 54 RDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQK 113
Query: 380 LCKIAPEGW---REQPQKTSMNTFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEE 436
L K + W R + + F FLR++ +V + ++ RH +Y L++ +L
Sbjct: 114 LSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRS 173
Query: 437 RLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSE 496
+ EE L ALQA+ G + +E + YF Y P +I + + +
Sbjct: 174 QCAHREEAYFLLAACALQADLGEH-RESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPT 232
Query: 497 MHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVK 556
+HR L ++A L F++ +L + V ++ +K+ + LG+ +GV +Y+ K
Sbjct: 233 LHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGK 292
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 98.2 bits (243), Expect = 4e-20
Identities = 126/542 (23%), Positives = 211/542 (38%), Gaps = 109/542 (20%)
Query: 721 DSLSGPPVQSMHAGSKNNRRKSFIAE--PGREIVRVTLKRDPHRGFGFVINEGEYSGQAD 778
++L+GP + ++ + I GR + L + P G GF + + +
Sbjct: 103 EALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGE 162
Query: 779 PGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEG-FTFNMAVRMIQNSPDNIELIISQ 837
GIF+ I G A + +K QILA+N +L+ T A+ ++Q + D ++L+I++
Sbjct: 163 LGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIAR 222
Query: 838 SK------GVGGNNPDEEKNSTANSG------------VSSTDILSFGYQGSLLSH---- 875
+ +P +A+S V+ L FG G +
Sbjct: 223 GSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVK 282
Query: 876 ---------------TQDQDRNTEELDMAGVQS-----LVPRLRHQLSFLPLKGAG---- 911
+ D + D+AG+ S ++ + +++ + +GA
Sbjct: 283 TILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERT 342
Query: 912 ---------SSCPPSPPEISA---------GEIYFVELVKEDGTLGFSVTGGI-NTSVPY 952
SS P S PE+ E + VEL K LG ++ G I + +
Sbjct: 343 APTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEP 402
Query: 953 GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERR 1012
GI+VKSI +G+I GD+++ VDG L G T++QAV+ L GQ L L RR
Sbjct: 403 SGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
Query: 1013 VPRSTQQCPSANDSMGD------------------------ERTAVSLVTALPGRP---S 1045
+ + S D D R L T G P +
Sbjct: 463 GMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSA 522
Query: 1046 SCVSVTDGPKFEVKLK---KNANGLGFSFVQMEKESCSH-------LKSDLVR--IKRLF 1093
+ D K E L + G+ + V S L++ + I+ +
Sbjct: 523 EIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVL 582
Query: 1094 PGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR--PPPGALPE 1151
P P +G + +GD +L VNG + G Q+V+++L+ P EVT++ CR PP E
Sbjct: 583 PEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSE 642
Query: 1152 LE 1153
L+
Sbjct: 643 LD 644
Score = 89.4 bits (220), Expect = 2e-17
Identities = 105/401 (26%), Positives = 175/401 (43%), Gaps = 55/401 (13%)
Query: 781 IFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSK- 839
I I + G A K + G QIL +N I L T + A+ +++ +P + L + + +
Sbjct: 1654 IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEA 1713
Query: 840 -------------------GVG-GNNPDEEKNSTANSGVSSTDILSFGY---QGSLLSHT 876
G G G + ++N T GV +DI+ G G L+
Sbjct: 1714 PYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDT---GVFVSDIVKGGIADADGRLMQGD 1770
Query: 877 QDQDRNTEELDMAGVQSLVPRLRHQLSFL-----PLKGAGSSCP---PSPPEISAGEIYF 928
Q N E++ A +++ L+ L PL G+ +S S A EI
Sbjct: 1771 QILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQG 1830
Query: 929 VELVK----EDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984
+ V+ +LG S+ GG+ + + I++ + P G AA+ ++ GDR++ + G
Sbjct: 1831 LRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGT 1890
Query: 985 ILCGLTHKQAVQCL-TGPGQVARLVL---ERRVPRSTQQCPSANDSMGDERTAVSLVTAL 1040
G+TH QAV L G + V+ + V QQ P+++ T+ S+
Sbjct: 1891 STEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDD 1950
Query: 1041 PGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEE 1100
G P C S+T L++ +GLGFS V L + +K +F A E
Sbjct: 1951 LG-PPQCKSIT--------LERGPDGLGFSIVGGYGSPHGDLP---IYVKTVFAKGAASE 1998
Query: 1101 NGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 1141
+G + GD I+AVNG+S EG+ +E + +L+ VTL++
Sbjct: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 87.4 bits (215), Expect = 8e-17
Identities = 99/403 (24%), Positives = 172/403 (42%), Gaps = 54/403 (13%)
Query: 780 GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQS- 838
GIF+ SI E I+ G QI+A++ +L+GFT AV +++++ + L + +
Sbjct: 404 GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRG 463
Query: 839 -KGVGGNNPDEEKNSTANSGVSSTDILSFGYQGS--LLSHTQDQD-RNTEE----LDMAG 890
K E+ A+ + I+ Y+ LS T++ + TEE L A
Sbjct: 464 MKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAE 523
Query: 891 VQSLVPRLRHQLSFLP----LKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGI 946
++ + + + + L + G EI + K G GI
Sbjct: 524 IEEIEDAQKQEAALLTKWQRIMGINY------------EIVVAHVSKFSENSGL----GI 567
Query: 947 NTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTG-PGQVA 1005
+ G +++S++P GP G++ GD LL+V+G+ L G H+ V L P +V
Sbjct: 568 SLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVT 627
Query: 1006 RLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSS-----CVSVTDGPKF---- 1056
+ R VP +TQ + D E T V SS +++TD +
Sbjct: 628 MVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEV 687
Query: 1057 ------------EVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAI 1104
++L+K + GLGFS ++ + S ++ I+ L PG AE++G +
Sbjct: 688 QAPLAMWEAGIQHIELEKGSKGLGFSI--LDYQDPIDPASTVIIIRSLVPGGIAEKDGRL 745
Query: 1105 AAGDIILAVNGRSTEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 1146
GD ++ VN + E +E + L+GAP V + + +P P
Sbjct: 746 LPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLP 788
Score = 80.5 bits (197), Expect = 1e-14
Identities = 92/424 (21%), Positives = 172/424 (40%), Gaps = 49/424 (11%)
Query: 753 RVTLKRDPHRGFGFVINEGE------YSGQADPGIFISSIIPGGPAEKAKTIKPGGQILA 806
RV L R+P + G I G +G+ GIFI ++ PA K T+KPG +I+
Sbjct: 1151 RVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVE 1210
Query: 807 LNHISLEGFTFNMAVRMIQNSPDNIELIISQ--SKGVGGNNPDEEKNSTANSGVSSTDIL 864
++ + L + AV I+ + + + ++ ++ P N SST+
Sbjct: 1211 VDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPF 1270
Query: 865 SFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEIS-- 922
+ Q + + E+ + V P ++ + + S +
Sbjct: 1271 ADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEF 1330
Query: 923 --------------AGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAK 968
GE++ +EL K LG S+ G + S +++ I P G A K
Sbjct: 1331 GYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM--SVFIVGIDPNGAAGK 1388
Query: 969 EGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQC-------- 1020
+G++ D LL+++G IL G +H+ A + +++ R Q
Sbjct: 1389 DGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVE 1448
Query: 1021 --PSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFE-VKLKKNANGLGFSFVQMEKE 1077
PS ++++ ++ T ++ T+ + V ++ + ++L K+ GLG + E++
Sbjct: 1449 PLPSNSENLQNKETEPTVTTS-----DAAVDLSSFKNVQHLELPKDQGGLGIAI--SEED 1501
Query: 1078 SCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEV 1137
+ S V IK L A +G + GD ILAV+ G ++ + LL+ A V
Sbjct: 1502 TLSG-----VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTV 1556
Query: 1138 TLLL 1141
L +
Sbjct: 1557 KLTI 1560
Score = 74.7 bits (182), Expect = 5e-13
Identities = 72/287 (25%), Positives = 127/287 (44%), Gaps = 65/287 (22%)
Query: 729 QSMHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIP 788
+S+ + SK N S I + + V +K+ P G I G S D IFI+ + P
Sbjct: 1813 ESLESSSKKNALASEI----QGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHP 1868
Query: 789 GGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVG---GNN 845
G A + + ++ G +I+ + S EG T AV +++N+ +IE+ + V G+
Sbjct: 1869 TGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQ 1928
Query: 846 PDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFL 905
+ +S + +G++S+ I +Q L
Sbjct: 1929 QEPASSSLSFTGLTSSSI----FQDDL--------------------------------- 1951
Query: 906 PLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGG--IYVKSIVPG 963
PP+ + + L + LGFS+ GG + P+G IYVK++
Sbjct: 1952 -----------GPPQCKS-----ITLERGPDGLGFSIVGGYGS--PHGDLPIYVKTVFAK 1993
Query: 964 GPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL-TGPGQVARLVL 1009
G A+++G++ +GD+++ V+G L G+TH++AV L G V +VL
Sbjct: 1994 GAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 73.2 bits (178), Expect = 2e-12
Identities = 88/369 (23%), Positives = 145/369 (39%), Gaps = 67/369 (18%)
Query: 763 GFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR 822
G G I+E + G+ I S+ G A +K G QILA++ + G+ +
Sbjct: 1492 GLGIAISEEDTLS----GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFIS 1547
Query: 823 MIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRN 882
+++ + ++L I NPD + +A S ++ +
Sbjct: 1548 LLKTAKMTVKLTIH------AENPDSQAVPSAAGAASG-----------------EKKNS 1584
Query: 883 TEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSV 942
++ L + S P S +S P + P I E +E+ K LG S+
Sbjct: 1585 SQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETT-IEISKGRTGLGLSI 1643
Query: 943 TGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPG 1002
GG +T + G I + + G A K+G++ GD++L+V+G+ L TH +A+ L
Sbjct: 1644 VGGSDTLL--GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTP 1701
Query: 1003 QVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKK 1062
Q RL L R + P + + D T E++ KK
Sbjct: 1702 QRVRLTLYR------DEAPYKEEEVCDTLT-----------------------IELQ-KK 1731
Query: 1063 NANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLI 1122
GLG S V ++ SD+V+ G A+ +G + GD IL VNG
Sbjct: 1732 PGKGLGLSIVG-KRNDTGVFVSDIVK------GGIADADGRLMQGDQILMVNGEDVRNAT 1784
Query: 1123 FQEVLHLLR 1131
+ V LL+
Sbjct: 1785 QEAVAALLK 1793
Score = 68.6 bits (166), Expect = 4e-11
Identities = 87/386 (22%), Positives = 153/386 (39%), Gaps = 73/386 (18%)
Query: 781 IFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKG 840
+FI I P G A K ++ ++L +N L G + A +I+ +P +++I ++K
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNK- 1433
Query: 841 VGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQD-QDRNTEELDMAGVQSLVPRLR 899
V+ + L S++++ Q++ TE P +
Sbjct: 1434 ---------------DAVNQMAVCPGNAVEPLPSNSENLQNKETE-----------PTVT 1467
Query: 900 HQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKS 959
+ + L S + +EL K+ G LG +++ S G+ +KS
Sbjct: 1468 TSDAAVDLS-------------SFKNVQHLELPKDQGGLGIAISEEDTLS----GVIIKS 1510
Query: 960 IVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQ 1019
+ G AA +G++ GD++L VD I+ G ++ + L +L + P S Q
Sbjct: 1511 LTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDS-QA 1569
Query: 1020 CPSANDSMGDER--TAVSLVTALPGRPS--------------------SCVSVTDGPKFE 1057
PSA + E+ ++ SL+ G P + + G +
Sbjct: 1570 VPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETT 1629
Query: 1058 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1117
+++ K GLG S V S + I ++ A ++G + AGD IL VNG
Sbjct: 1630 IEISKGRTGLGLSIV-----GGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
Query: 1118 TEGLIFQEVLHLLRGAPQEVTLLLCR 1143
E +++LR PQ V L L R
Sbjct: 1685 LRKATHDEAINVLRQTPQRVRLTLYR 1710
Score = 60.5 bits (145), Expect = 1e-08
Identities = 59/242 (24%), Positives = 103/242 (42%), Gaps = 29/242 (11%)
Query: 782 FISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGV 841
FI S++P GP + + G ++L +N I+L G V +++ P + ++ +
Sbjct: 577 FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCR---- 632
Query: 842 GGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQ 901
T S + S D+ D E + + +
Sbjct: 633 ------RTVPPTTQSELDSLDLC---------------DIELTEKPHVDLGEFIGSSETE 671
Query: 902 LSFLPLKGAGSSCPPSPPEISAGE--IYFVELVKEDGTLGFSVTGGINTSVPYGG-IYVK 958
L + AG S ++ E I +EL K LGFS+ + P I ++
Sbjct: 672 DPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIR 731
Query: 959 SIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTG-PGQVARLVLERRVPRST 1017
S+VPGG A K+G++L GDRL+ V+ V L + ++AV+ L G P R+ + + +P S
Sbjct: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
Query: 1018 QQ 1019
++
Sbjct: 792 EE 793
Score = 45.4 bits (106), Expect = 3e-04
Identities = 86/410 (20%), Positives = 153/410 (37%), Gaps = 82/410 (20%)
Query: 762 RGFGFVINEGEYSGQADPG---IFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFN 818
+G GF I + Y DP I I S++PGG AEK + PG +++ +N ++LE +
Sbjct: 708 KGLGFSILD--YQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLE 765
Query: 819 MAVRMIQNSPDNI-------ELIISQSKGVGGNNPDE--------EKNSTANSGVSSTDI 863
AV ++ +P L +S +G D E+ A+ + D+
Sbjct: 766 EAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADL 825
Query: 864 LSFGYQGSLL--SHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPE- 920
G + L T + + E + Q+ + L H S GSS P SPP+
Sbjct: 826 ALVGTNDADLVDESTFESPYSPENDSIYSTQASILSL-HGSSCGDGLNYGSSLPSSPPKD 884
Query: 921 -------------ISAGEIYFVELV--KEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGP 965
+S E+Y L+ +++ T ++ G P G + P
Sbjct: 885 VIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMG-----PASGFTINDYTPANA 939
Query: 966 AAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSAND 1025
++ + + I+ +H P +V S+ + PS
Sbjct: 940 IEQQ---------YECENTIVWTESHL--------PSEVI----------SSAELPSVLP 972
Query: 1026 SMGDERTAVSLVTALPGRPSSCVSVTDGPK--FE--VKLKKNANGLGFSFVQMEKESCSH 1081
+ + L + + CV + + K FE + + K + LG + V K+
Sbjct: 973 DSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMT-VSANKDGLGM 1031
Query: 1082 LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLR 1131
+ ++ + G +G IA GD IL++N ST + + +LR
Sbjct: 1032 I------VRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 43.9 bits (102), Expect = 0.001
Identities = 52/252 (20%), Positives = 101/252 (40%), Gaps = 34/252 (13%)
Query: 929 VELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCG 988
+ + K + +LG +V+ + G+ V+SI+ GG +++G+I GD +L ++
Sbjct: 1009 INIAKGNSSLGMTVSANKDGL----GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 989 LTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDER---TAVSLVTALPGRP- 1044
+T+ QA L + + VP + S+G + A+ + ++ GR
Sbjct: 1065 VTNAQARAMLRRHSLIGPDIKITYVP--AEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
Query: 1045 -----------------SSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV 1087
++ S + P+ ++ + LG S V +++
Sbjct: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
Query: 1088 R---IKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL----L 1140
R IK + PA +NG + GD I+ V+G ++ + +R A V +
Sbjct: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSI 1242
Query: 1141 LCRPPPGALPEL 1152
+ RP LP L
Sbjct: 1243 INRPRKSPLPSL 1254
Score = 32.7 bits (73), Expect = 2.3
Identities = 22/86 (25%), Positives = 40/86 (46%), Gaps = 5/86 (5%)
Query: 1058 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1117
++L+K +GLG S + S V I + P A ++G + D +L +NG+
Sbjct: 1351 IELEKGHSGLGLSLAGNKDRSRMS-----VFIVGIDPNGAAGKDGRLQIADELLEINGQI 1405
Query: 1118 TEGLIFQEVLHLLRGAPQEVTLLLCR 1143
G Q +++ AP +V ++ R
Sbjct: 1406 LYGRSHQNASSIIKCAPSKVKIIFIR 1431
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 96.7 bits (239), Expect = 1e-19
Identities = 78/262 (29%), Positives = 120/262 (45%), Gaps = 28/262 (10%)
Query: 324 VVLLNGQHLEVKCDVE--STVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLC 381
V+LL+G E CDVE S +F+ V NL E YFGL Y D+E +
Sbjct: 114 VILLDGS--EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYR--------DAENQKN 163
Query: 382 KIAPEGWREQPQKTSMNTFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCN 441
+ P +E ++ + +KF+ L +TR+ LQLR DI+ RL C+
Sbjct: 164 WLDPA--KEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCS 221
Query: 442 EEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLS 501
L LG +Q+E G+Y ++ S DYI ++ +V E+H+
Sbjct: 222 FVTLALLGSYTVQSELGDYDPDECGS-------DYISEFRFAPNHTKELEDKVIELHKSH 274
Query: 502 SALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRI 561
+ +AE+ FL ++L YGV +H K E+ LG+CA G+++Y R+
Sbjct: 275 RGMTPAEAEMHFLENAKKLSMYGVDLHHA---KDSEGVEIMLGVCASGLLIY----RDRL 327
Query: 562 AMLRFQWRETGKISTYQKKFTI 583
+ RF W + KIS + F I
Sbjct: 328 RINRFAWPKVLKISYKRNNFYI 349
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 95.1 bits (235), Expect = 4e-19
Identities = 79/286 (27%), Positives = 129/286 (45%), Gaps = 17/286 (5%)
Query: 332 LEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQ 391
LE +T +F+ V L E+ +FGL Y +K F + K+ + +
Sbjct: 16 LEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGF------STWLKLNKKVTAQD 69
Query: 392 PQKTSMNTFTLFLRIKFFVSHYGL-LQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGV 450
+K S F R KF+ L +T+ F+LQ+++ IL + +YC E + L
Sbjct: 70 VRKESPLLFKF--RAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLAS 127
Query: 451 LALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVE--VSEMHRLSSALWGED 508
A+Q+++G++ KE V Y + +P ++E+ + Q E + H + ED
Sbjct: 128 YAVQSKYGDFNKE-VHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLRED 186
Query: 509 AELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQW 568
A L++L++ Q L YGV FS K + E+ LG+ A G+ +YE +N+ + F W
Sbjct: 187 AVLEYLKIAQDLEMYGV---NYFSIKNKKGSELWLGVDALGLNIYE-QNDRLTPKIGFPW 242
Query: 569 RETGKISTYQKKFTITS-SVTGKKHTFVTDSAKTSKYLLDLCSAQH 613
E IS KKF I F + +K +L LC H
Sbjct: 243 SEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNH 288
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 94.7 bits (234), Expect = 5e-19
Identities = 75/286 (26%), Positives = 129/286 (45%), Gaps = 17/286 (5%)
Query: 332 LEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQ 391
LE +T +F+ V L E+ +FGL Y+ SK + + K+ + ++
Sbjct: 16 LEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGY------STWLKLNKKVTQQD 69
Query: 392 PQKTSMNTFTLFLRIKFFVSHYGL-LQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGV 450
+K N R KFF L +T+ F+LQ+++ IL + +YC E + L
Sbjct: 70 VKKE--NPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLAS 127
Query: 451 LALQAEFGNYPKEQVESKPYFHVEDYIPASLIE--RMTALRVQVEVSEMHRLSSALWGED 508
A+QA++G+Y KE + Y + +P ++E ++T + + + H + ED
Sbjct: 128 YAVQAKYGDYNKE-IHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLRED 186
Query: 509 AELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQW 568
+ +++L++ Q L YGV F K + E+ LG+ A G+ +YE ++ + F W
Sbjct: 187 SMMEYLKIAQDLEMYGV---NYFEIKNKKGTELWLGVDALGLNIYE-HDDKLTPKIGFPW 242
Query: 569 RETGKISTYQKKFTITS-SVTGKKHTFVTDSAKTSKYLLDLCSAQH 613
E IS KKF I F + +K +L LC H
Sbjct: 243 SEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNH 288
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 94.7 bits (234), Expect = 5e-19
Identities = 75/287 (26%), Positives = 138/287 (48%), Gaps = 20/287 (6%)
Query: 332 LEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQ 391
+E C+++ +F+ V L E +FGL Y +L + ++ + + +E+
Sbjct: 33 MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKV--LDHDVSKEE 90
Query: 392 PQKTSMNTFTLFLRIKFFVSHYGL-LQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGV 450
P T KF+ + L +T+H F+LQ++K IL+E++YC E + L
Sbjct: 91 P-------VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLAS 143
Query: 451 LALQAEFGNYPKEQVESKPYFHVEDYIPASLIE--RMTALRVQVEVSEMHRLSSALWGED 508
A+QA++G+Y V + + E+ +P +I +MT + ++ + ++
Sbjct: 144 YAVQAKYGDY-DPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDE 202
Query: 509 AELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQW 568
AE+++L++ Q L YGV F+ + + E+ LG+ A G+ +Y+ +N + F W
Sbjct: 203 AEMEYLKIAQDLEMYGV---NYFAIRNKKGTELLLGVDALGLHIYDPENR-LTPKISFPW 258
Query: 569 RETGKISTYQKKFTITSSVTGKKHTFVTDSAK--TSKYLLDLCSAQH 613
E IS K+FTI + K F +S+K +K +L LC H
Sbjct: 259 NEIRNISYSDKEFTI-KPLDKKIDVFKFNSSKLRVNKLILQLCIGNH 304
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 94.7 bits (234), Expect = 5e-19
Identities = 75/287 (26%), Positives = 138/287 (48%), Gaps = 20/287 (6%)
Query: 332 LEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQ 391
+E C+++ +F+ V L E +FGL Y +L + ++ + + +E+
Sbjct: 33 MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKV--LDHDVSKEE 90
Query: 392 PQKTSMNTFTLFLRIKFFVSHYGL-LQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGV 450
P T KF+ + L +T+H F+LQ++K IL+E++YC E + L
Sbjct: 91 P-------VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLAS 143
Query: 451 LALQAEFGNYPKEQVESKPYFHVEDYIPASLIE--RMTALRVQVEVSEMHRLSSALWGED 508
A+QA++G+Y V + + E+ +P +I +MT + ++ + ++
Sbjct: 144 YAVQAKYGDY-DPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDE 202
Query: 509 AELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQW 568
AE+++L++ Q L YGV F+ + + E+ LG+ A G+ +Y+ +N + F W
Sbjct: 203 AEMEYLKIAQDLEMYGV---NYFAIRNKKGTELLLGVDALGLHIYDPENR-LTPKISFPW 258
Query: 569 RETGKISTYQKKFTITSSVTGKKHTFVTDSAK--TSKYLLDLCSAQH 613
E IS K+FTI + K F +S+K +K +L LC H
Sbjct: 259 NEIRNISYSDKEFTI-KPLDKKIDVFKFNSSKLRVNKLILQLCIGNH 304
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 94.7 bits (234), Expect = 5e-19
Identities = 75/287 (26%), Positives = 138/287 (48%), Gaps = 20/287 (6%)
Query: 332 LEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQ 391
+E C+++ +F+ V L E +FGL Y +L + ++ + + +E+
Sbjct: 33 MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKV--LDHDVSKEE 90
Query: 392 PQKTSMNTFTLFLRIKFFVSHYGL-LQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGV 450
P T KF+ + L +T+H F+LQ++K IL+E++YC E + L
Sbjct: 91 P-------VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLAS 143
Query: 451 LALQAEFGNYPKEQVESKPYFHVEDYIPASLIE--RMTALRVQVEVSEMHRLSSALWGED 508
A+QA++G+Y V + + E+ +P +I +MT + ++ + ++
Sbjct: 144 YAVQAKYGDY-DPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDE 202
Query: 509 AELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQW 568
AE+++L++ Q L YGV F+ + + E+ LG+ A G+ +Y+ +N + F W
Sbjct: 203 AEMEYLKIAQDLEMYGV---NYFAIRNKKGTELLLGVDALGLHIYDPENR-LTPKISFPW 258
Query: 569 RETGKISTYQKKFTITSSVTGKKHTFVTDSAK--TSKYLLDLCSAQH 613
E IS K+FTI + K F +S+K +K +L LC H
Sbjct: 259 NEIRNISYSDKEFTI-KPLDKKIDVFKFNSSKLRVNKLILQLCIGNH 304
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 94.7 bits (234), Expect = 5e-19
Identities = 75/287 (26%), Positives = 138/287 (48%), Gaps = 20/287 (6%)
Query: 332 LEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQ 391
+E C+++ +F+ V L E +FGL Y +L + ++ + + +E+
Sbjct: 33 MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKV--LDHDVSKEE 90
Query: 392 PQKTSMNTFTLFLRIKFFVSHYGL-LQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGV 450
P T KF+ + L +T+H F+LQ++K IL+E++YC E + L
Sbjct: 91 P-------VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLAS 143
Query: 451 LALQAEFGNYPKEQVESKPYFHVEDYIPASLIE--RMTALRVQVEVSEMHRLSSALWGED 508
A+QA++G+Y V + + E+ +P +I +MT + ++ + ++
Sbjct: 144 YAVQAKYGDY-DPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDE 202
Query: 509 AELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQW 568
AE+++L++ Q L YGV F+ + + E+ LG+ A G+ +Y+ +N + F W
Sbjct: 203 AEMEYLKIAQDLEMYGV---NYFAIRNKKGTELLLGVDALGLHIYDPENR-LTPKISFPW 258
Query: 569 RETGKISTYQKKFTITSSVTGKKHTFVTDSAK--TSKYLLDLCSAQH 613
E IS K+FTI + K F +S+K +K +L LC H
Sbjct: 259 NEIRNISYSDKEFTI-KPLDKKIDVFKFNSSKLRVNKLILQLCIGNH 304
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,005,479
Number of Sequences: 37866
Number of extensions: 2595099
Number of successful extensions: 8286
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 169
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 7156
Number of HSP's gapped (non-prelim): 889
length of query: 1287
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1173
effective length of database: 13,930,794
effective search space: 16340821362
effective search space used: 16340821362
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.