Guide to the Human Genome
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Search of human proteins with 109809739

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109809739 La ribonucleoprotein domain family, member 7 [Homo
sapiens]
         (582 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109809739 La ribonucleoprotein domain family, member 7 [Homo ...  1144   0.0  
gi|109809741 La ribonucleoprotein domain family, member 7 [Homo ...  1144   0.0  
gi|10835067 autoantigen La [Homo sapiens]                              84   5e-16
gi|37537710 La ribonucleoprotein domain family, member 6 isoform...    80   5e-15
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    65   2e-10
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...    65   2e-10
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    59   2e-08
gi|61102725 la related protein isoform 2 [Homo sapiens]                58   2e-08
gi|39725634 la related protein isoform 1 [Homo sapiens]                58   2e-08
gi|118600973 RNA binding motif protein, X-linked 2 [Homo sapiens]      57   6e-08
gi|40353736 c-Mpl binding protein isoform c [Homo sapiens]             56   1e-07
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            55   2e-07
gi|222352111 MKI67 interacting nucleolar phosphoprotein [Homo sa...    55   2e-07
gi|187960109 RNA binding motif protein 28 [Homo sapiens]               54   3e-07
gi|40353740 c-Mpl binding protein isoform b [Homo sapiens]             54   3e-07
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          54   4e-07
gi|40353738 c-Mpl binding protein isoform a [Homo sapiens]             54   4e-07
gi|238859597 RNA binding motif protein 34 isoform 1 [Homo sapiens]     54   5e-07
gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]    53   7e-07
gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]    53   7e-07
gi|40068059 CBF1 interacting corepressor [Homo sapiens]                53   9e-07
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1...    53   9e-07
gi|27734775 hypothetical protein LOC286499 [Homo sapiens]              52   2e-06
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     52   2e-06
gi|104526627 triadin [Homo sapiens]                                    52   2e-06
gi|54112403 chromodomain helicase DNA binding protein 7 [Homo sa...    50   4e-06
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           50   4e-06
gi|221219020 NYD-SP11 protein [Homo sapiens]                           50   6e-06
gi|87299628 biorientation of chromosomes in cell division 1-like...    50   6e-06
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...    50   7e-06

>gi|109809739 La ribonucleoprotein domain family, member 7 [Homo
           sapiens]
          Length = 582

 Score = 1144 bits (2958), Expect = 0.0
 Identities = 582/582 (100%), Positives = 582/582 (100%)

Query: 1   METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQ 60
           METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQ
Sbjct: 1   METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQ 60

Query: 61  IEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPK 120
           IEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPK
Sbjct: 61  IEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPK 120

Query: 121 DEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAA 180
           DEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAA
Sbjct: 121 DEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAA 180

Query: 181 KAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEEN 240
           KAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEEN
Sbjct: 181 KAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEEN 240

Query: 241 MDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSS 300
           MDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSS
Sbjct: 241 MDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSS 300

Query: 301 EDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHK 360
           EDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHK
Sbjct: 301 EDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHK 360

Query: 361 KKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSG 420
           KKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSG
Sbjct: 361 KKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSG 420

Query: 421 VPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISE 480
           VPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISE
Sbjct: 421 VPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISE 480

Query: 481 VLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDR 540
           VLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDR
Sbjct: 481 VLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDR 540

Query: 541 QAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD 582
           QAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD
Sbjct: 541 QAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD 582


>gi|109809741 La ribonucleoprotein domain family, member 7 [Homo
           sapiens]
          Length = 582

 Score = 1144 bits (2958), Expect = 0.0
 Identities = 582/582 (100%), Positives = 582/582 (100%)

Query: 1   METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQ 60
           METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQ
Sbjct: 1   METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQ 60

Query: 61  IEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPK 120
           IEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPK
Sbjct: 61  IEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPK 120

Query: 121 DEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAA 180
           DEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAA
Sbjct: 121 DEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAA 180

Query: 181 KAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEEN 240
           KAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEEN
Sbjct: 181 KAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEEN 240

Query: 241 MDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSS 300
           MDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSS
Sbjct: 241 MDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSS 300

Query: 301 EDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHK 360
           EDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHK
Sbjct: 301 EDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHK 360

Query: 361 KKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSG 420
           KKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSG
Sbjct: 361 KKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSG 420

Query: 421 VPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISE 480
           VPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISE
Sbjct: 421 VPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISE 480

Query: 481 VLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDR 540
           VLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDR
Sbjct: 481 VLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDR 540

Query: 541 QAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD 582
           QAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD
Sbjct: 541 QAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD 582


>gi|10835067 autoantigen La [Homo sapiens]
          Length = 408

 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 67/228 (29%), Positives = 117/228 (51%), Gaps = 20/228 (8%)

Query: 24  EKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKL 83
           E     ++  + A I  Q++++FGD NL +D+FL+EQI K  +G+V + +++ FN++ +L
Sbjct: 3   ENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQI-KLDEGWVPLEIMIKFNRLNRL 61

Query: 84  TTDGKLIARALRSS--AVVELDLEGTRIRR--KKPL----GERPKDEDERTVYVELLPKN 135
           TTD  +I  AL  S   ++E+  + T+IRR   KPL     E   D   R+VY++  P +
Sbjct: 62  TTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTD 121

Query: 136 VNHSWIERVFGKCGNVVYISIPH--YKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEA 193
                I+      G V+ I +    +K+    KG  FV F++ E A K +E      +E 
Sbjct: 122 ATLDDIKEWLEDKGQVLNIQMRRTLHKAF---KGSIFVVFDSIESAKKFVETPGQKYKET 178

Query: 194 PR----KPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAK 237
                 K   F K  KN+     +V  + + K++++ + K E++ + K
Sbjct: 179 DLLILFKDDYFAK--KNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMK 224



 Score = 30.0 bits (66), Expect = 6.1
 Identities = 23/79 (29%), Positives = 39/79 (49%), Gaps = 8/79 (10%)

Query: 480 EVLYVDLLEGDTECHARFKTPED-----AQAVINAYTEI-NKKHCWKLEILSGDHEQRYW 533
           E+ ++D + G  E    FK         A+   N   ++ NK+  W  E+L G+ E+   
Sbjct: 258 EIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTW--EVLEGEVEKEAL 315

Query: 534 QKILVDRQAKLNQPREKKR 552
           +KI+ D+Q  LN+ + K R
Sbjct: 316 KKIIEDQQESLNKWKSKGR 334


>gi|37537710 La ribonucleoprotein domain family, member 6 isoform 1
           [Homo sapiens]
          Length = 491

 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 72/277 (25%), Positives = 127/277 (45%), Gaps = 42/277 (15%)

Query: 19  KKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFN 78
           +++++E++ +   ++++  +  Q++F+F D NL KD FL + + +++ GYV + LL SF 
Sbjct: 77  EREDLEQEWKPPDEELIKKLVDQIEFYFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFK 136

Query: 79  KMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKD---EDERTVY-VELLPK 134
           K+K LT D +  A AL+ S V+EL+ +  ++RR  P+   P +        VY + L PK
Sbjct: 137 KVKHLTRDWRTTAHALKYSVVLELNEDHRKVRRTTPVPLFPNENLPSKMLLVYDLYLSPK 196

Query: 135 -----------NVNHSWIE---RVFGKCGNVVYISI---------------PHYKSTGDP 165
                       V    +E   ++FG  G +  + I                 Y   G  
Sbjct: 197 LWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQ 256

Query: 166 KGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKK 225
           +  A VEFE  E A KA EF+     E+  K  +    +  KP P  +  ++K   ++  
Sbjct: 257 E-CAIVEFEEVEAAIKAHEFMIT---ESQGKENMKAVLIGMKP-PKKKPAKDKNHDEEPT 311

Query: 226 GRMKKEDNIQAKEENM----DTSNTSISKMKRSRPTS 258
             +    ++  + E +    D S+ + S    S PTS
Sbjct: 312 ASIHLNKSLNKRVEELQYMGDESSANSSSDPESNPTS 348


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 81/381 (21%), Positives = 143/381 (37%), Gaps = 54/381 (14%)

Query: 121 DEDERTVYV-ELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQA 179
           DE  RTVYV  L  +      +   F + G V ++ +   ++   P  FAFVEF  +   
Sbjct: 178 DEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDET--QPTRFAFVEFADQNSV 235

Query: 180 AKAIEF------------------LNNPPEEAPRKPGIFPKTVKNKPIPALRVV------ 215
            +A+ F                  +  PPE  P+      + V  +   A   +      
Sbjct: 236 PRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEP 295

Query: 216 EEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMK-RSRPTSEGSDIESTEPQKQCSK 274
           E  K  ++K GR +     +++  +   S    S+ K RSR  +     +    + +   
Sbjct: 296 ESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPH 355

Query: 275 KKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDI 334
           KK+ + R    S        R RS S D      +   +KI +K+ +KE     +  R+ 
Sbjct: 356 KKRSKSRERRKS--------RSRSHSRDKR----KDTREKIKEKERVKEKDREKEREREK 403

Query: 335 EISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLAL 394
           E   E+E+     +D    K + K K+K +ER +            K    D  KE    
Sbjct: 404 EREKEKERGKNKDRDKEREKDREKDKEKDRERER-----------EKEHEKDRDKEKEKE 452

Query: 395 QKASMASLKKTISQIKSESEMETDSGVPQNT--GMKNEKTANREECRTQEKVNATGPQFV 452
           Q       K    +I  + + +  S  P  +    +  ++++RE  R + + ++  P+  
Sbjct: 453 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPR-T 511

Query: 453 SGVIVKIISTEPLPGRKQVRD 473
           S  I +  S  P P  +  +D
Sbjct: 512 SKTIKRKSSRSPSPRSRNKKD 532



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 44/153 (28%), Positives = 74/153 (48%), Gaps = 29/153 (18%)

Query: 216 EEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKK 275
           E+ K+K+++K R K+ D  + K++   T   S +  +RSR +S               ++
Sbjct: 452 EQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR--------------ER 497

Query: 276 KKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIE 335
           +++R R  + S    +T KRK S S      +PRS+ KK  +++  KE    S E R+ E
Sbjct: 498 RRRRSRSSSRSPRTSKTIKRKSSRSP-----SPRSRNKKDKKRE--KERDHIS-ERRERE 549

Query: 336 ISTEEEKDTGDL-------KDSSLLKTKRKHKK 361
            ST   K + D        K+S+ LK K  +K+
Sbjct: 550 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE 582



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 10/136 (7%)

Query: 215 VEEKKKKKKKKGRMKKEDNI-----QAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQ 269
           ++EK+KK KK     +  N       +  E     + S S+  R+  T +     S  P+
Sbjct: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 526

Query: 270 ---KQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEA-S 325
              K+  K++K+RD +      E  T  RK S+  D +    ++    + +K+  KE  S
Sbjct: 527 SRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNST-SLKEKEHNKEPDS 585

Query: 326 EASKENRDIEISTEEE 341
             SKE  D +    EE
Sbjct: 586 SVSKEVDDKDAPRTEE 601



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 42/224 (18%), Positives = 78/224 (34%), Gaps = 8/224 (3%)

Query: 215 VEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSK 274
           ++EK++ K+K    ++E   + ++E     N    K +      +       E +K+  K
Sbjct: 384 IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEK 443

Query: 275 KKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDI 334
            + K    E     E    + K    +  +    R+  +        + +S   +  R  
Sbjct: 444 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 503

Query: 335 EISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLAL 394
             S          + SS   + R   KK K+R K  + +   R   +S  M         
Sbjct: 504 SSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN---- 559

Query: 395 QKASMASLKKTISQIK-SESEMETDSGVPQNTGMKNEKTANREE 437
            +     L+K  + +K  E   E DS V +     ++K A R E
Sbjct: 560 DRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEV---DDKDAPRTE 600



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 32/114 (28%), Positives = 50/114 (43%), Gaps = 22/114 (19%)

Query: 202 KTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGS 261
           KT+K K   + R    + + KK K R K+ D+I  + E     +TS+ K    R   E  
Sbjct: 513 KTIKRK---SSRSPSPRSRNKKDKKREKERDHISERRER--ERSTSMRKSSNDRDGKEKL 567

Query: 262 DIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKI 315
           +  ST      S K+K+ ++   SS+           S E  +  APR++  KI
Sbjct: 568 EKNST------SLKEKEHNKEPDSSV-----------SKEVDDKDAPRTEENKI 604


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 81/381 (21%), Positives = 143/381 (37%), Gaps = 54/381 (14%)

Query: 121 DEDERTVYV-ELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQA 179
           DE  RTVYV  L  +      +   F + G V ++ +   ++   P  FAFVEF  +   
Sbjct: 62  DEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDET--QPTRFAFVEFADQNSV 119

Query: 180 AKAIEF------------------LNNPPEEAPRKPGIFPKTVKNKPIPALRVV------ 215
            +A+ F                  +  PPE  P+      + V  +   A   +      
Sbjct: 120 PRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEP 179

Query: 216 EEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMK-RSRPTSEGSDIESTEPQKQCSK 274
           E  K  ++K GR +     +++  +   S    S+ K RSR  +     +    + +   
Sbjct: 180 ESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPH 239

Query: 275 KKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDI 334
           KK+ + R    S        R RS S D      +   +KI +K+ +KE     +  R+ 
Sbjct: 240 KKRSKSRERRKS--------RSRSHSRDKR----KDTREKIKEKERVKEKDREKEREREK 287

Query: 335 EISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLAL 394
           E   E+E+     +D    K + K K+K +ER +            K    D  KE    
Sbjct: 288 EREKEKERGKNKDRDKEREKDREKDKEKDRERER-----------EKEHEKDRDKEKEKE 336

Query: 395 QKASMASLKKTISQIKSESEMETDSGVPQNT--GMKNEKTANREECRTQEKVNATGPQFV 452
           Q       K    +I  + + +  S  P  +    +  ++++RE  R + + ++  P+  
Sbjct: 337 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPR-T 395

Query: 453 SGVIVKIISTEPLPGRKQVRD 473
           S  I +  S  P P  +  +D
Sbjct: 396 SKTIKRKSSRSPSPRSRNKKD 416



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 44/153 (28%), Positives = 74/153 (48%), Gaps = 29/153 (18%)

Query: 216 EEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKK 275
           E+ K+K+++K R K+ D  + K++   T   S +  +RSR +S               ++
Sbjct: 336 EQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR--------------ER 381

Query: 276 KKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIE 335
           +++R R  + S    +T KRK S S      +PRS+ KK  +++  KE    S E R+ E
Sbjct: 382 RRRRSRSSSRSPRTSKTIKRKSSRSP-----SPRSRNKKDKKRE--KERDHIS-ERRERE 433

Query: 336 ISTEEEKDTGDL-------KDSSLLKTKRKHKK 361
            ST   K + D        K+S+ LK K  +K+
Sbjct: 434 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE 466



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 10/136 (7%)

Query: 215 VEEKKKKKKKKGRMKKEDNI-----QAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQ 269
           ++EK+KK KK     +  N       +  E     + S S+  R+  T +     S  P+
Sbjct: 351 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 410

Query: 270 ---KQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEA-S 325
              K+  K++K+RD +      E  T  RK S+  D +    ++    + +K+  KE  S
Sbjct: 411 SRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNST-SLKEKEHNKEPDS 469

Query: 326 EASKENRDIEISTEEE 341
             SKE  D +    EE
Sbjct: 470 SVSKEVDDKDAPRTEE 485



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 42/224 (18%), Positives = 78/224 (34%), Gaps = 8/224 (3%)

Query: 215 VEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSK 274
           ++EK++ K+K    ++E   + ++E     N    K +      +       E +K+  K
Sbjct: 268 IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEK 327

Query: 275 KKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDI 334
            + K    E     E    + K    +  +    R+  +        + +S   +  R  
Sbjct: 328 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 387

Query: 335 EISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLAL 394
             S          + SS   + R   KK K+R K  + +   R   +S  M         
Sbjct: 388 SSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN---- 443

Query: 395 QKASMASLKKTISQIK-SESEMETDSGVPQNTGMKNEKTANREE 437
            +     L+K  + +K  E   E DS V +     ++K A R E
Sbjct: 444 DRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEV---DDKDAPRTE 484



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 32/114 (28%), Positives = 50/114 (43%), Gaps = 22/114 (19%)

Query: 202 KTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGS 261
           KT+K K   + R    + + KK K R K+ D+I  + E     +TS+ K    R   E  
Sbjct: 397 KTIKRK---SSRSPSPRSRNKKDKKREKERDHISERRER--ERSTSMRKSSNDRDGKEKL 451

Query: 262 DIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKI 315
           +  ST      S K+K+ ++   SS+           S E  +  APR++  KI
Sbjct: 452 EKNST------SLKEKEHNKEPDSSV-----------SKEVDDKDAPRTEENKI 488


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 97/419 (23%), Positives = 164/419 (39%), Gaps = 99/419 (23%)

Query: 218 KKKKKKKKGRMKKEDNIQAKE---------------------ENMDTSNTSISKMKRSRP 256
           KKKK+KKK    ++D ++  E                     EN +   TS  K K+ + 
Sbjct: 43  KKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQK 102

Query: 257 TSEGS--DIESTEPQKQCSKKKK-KRDRVEASS----------LPEVRTGKRKRSSSEDA 303
             + S  D +S E + + SK KK  + +VE  S          LP+   GK ++S+ +  
Sbjct: 103 GKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWD 162

Query: 304 ESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEK-----------DTGDLKDSSL 352
            S       KKI ++  I  + E+  E+ +   S + +K           ++G+  D + 
Sbjct: 163 GSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDAS 222

Query: 353 LKTK----RKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQ 408
            K K    +K +KK +ER K  EE   LR L + E ++  K+  + QK S    ++   +
Sbjct: 223 FKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVK 282

Query: 409 IK----------SESEMETDSGV-PQNTG--MKNEKTANREECRTQEKVNATGPQFVSGV 455
            K          SE + ET +     N G   K +K   + E   +EK    GP      
Sbjct: 283 SKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPS----- 337

Query: 456 IVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHARFKTPEDAQAVINAYTEINK 515
                           + T+ A+ E L            A+ K  E+ Q       E   
Sbjct: 338 ----------------KATVKAMQEAL------------AKLKEEEERQ---KREEEERI 366

Query: 516 KHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASK 574
           K   +LE      E+R  Q+    ++ K  + +E+ +   KL+TK+++   A+ +   K
Sbjct: 367 KRLEELE-AKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLK 424



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 71/327 (21%), Positives = 125/327 (38%), Gaps = 58/327 (17%)

Query: 168 FAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNK--------------PIPALR 213
           F   + + K Q  K   F +N  EE   K     KT K K               +P   
Sbjct: 91  FTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA 150

Query: 214 VVEEKKKKKKKKGRMKKEDN---------IQAKEENMDTSNTSISK---MKRSRPTSEGS 261
             + +K  KK  G  + EDN         I +  E+ D S+  +      K+++    G 
Sbjct: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGP 210

Query: 262 DIES------------TEPQKQCSKK---KKKRDRVEAS-----SLPEVRTGKRKRSSSE 301
           +IES            T  QK+  KK   +KKRD  +A         E+ TGK+ +S  +
Sbjct: 211 NIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQK 270

Query: 302 DAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKK 361
           +++       VK  +  D       AS+E  +   + E++ + GD         K+K  K
Sbjct: 271 ESQRKFEEETVKSKVTVDT--GVIPASEEKAETPTAAEDDNE-GD---------KKKKDK 318

Query: 362 KHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSGV 421
           K K+  K  +E    +  SK+    +++    L++      ++   +IK   E+E     
Sbjct: 319 KKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKE 378

Query: 422 PQNTGMKNEKTANREECRTQEKVNATG 448
            +    +  +   ++E   +E++   G
Sbjct: 379 EERLEQEKRERKKQKEKERKERLKKEG 405



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 47/199 (23%), Positives = 88/199 (44%), Gaps = 22/199 (11%)

Query: 217 EKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKK 276
           +K + K+K+ + K E+     +  +DT     S+ K   PT+   D E  + +K   KKK
Sbjct: 263 KKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKK--DKKK 320

Query: 277 KKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEI 336
           KK ++ E     E + G  K +     E+LA             +KE  E  K   +  I
Sbjct: 321 KKGEKEEKEK--EKKKGPSKATVKAMQEALAK------------LKEEEERQKREEEERI 366

Query: 337 STEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQK 396
              EE +    K+   L+ +++ +KK KE+ +        ++L+KS+     +E  A  +
Sbjct: 367 KRLEELE-AKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQ-----REARARAE 420

Query: 397 ASMASLKKTISQIKSESEM 415
           A++  L+    ++ S+  +
Sbjct: 421 ATLKLLQAQGVEVPSKDSL 439



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 45/228 (19%), Positives = 97/228 (42%), Gaps = 27/228 (11%)

Query: 216 EEKKKKKKKKGRMKKEDNIQAK---EENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQC 272
           ++KK KKKKKG  ++++  + K   +  +     +++K+K      +  + E  +  ++ 
Sbjct: 313 KKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEEL 372

Query: 273 SKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENR 332
             K+K+ +R+E          KR+R   ++ E      K  K++ K   +  + A    +
Sbjct: 373 EAKRKEEERLEQE--------KRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLK 424

Query: 333 DIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSK--SEWMDLKKE 390
            ++    E      L     +   +K KK            IP ++ SK  SE M+L   
Sbjct: 425 LLQAQGVEVPSKDSLPKKRPIYEDKKRKK------------IPQQLESKEVSESMELCAA 472

Query: 391 YLALQKASMASLKKTISQIKSESEMET-DSGVPQNTGMKNEKTANREE 437
            + + +  +   ++T   ++ E E +T D+G+     M +++   + E
Sbjct: 473 -VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVE 519



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 76/386 (19%), Positives = 142/386 (36%), Gaps = 53/386 (13%)

Query: 10  KVMEEESTEKKKEVEKKKR---SRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRD 66
           K M+E   + K+E E++KR    R+K++    AK+           K+    EQ ++ R 
Sbjct: 342 KAMQEALAKLKEEEERQKREEEERIKRLEELEAKR-----------KEEERLEQEKRERK 390

Query: 67  GYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPL-GERPKDEDER 125
              +        K  KL T  +  ARA   + +  L  +G  +  K  L  +RP  ED++
Sbjct: 391 KQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKK 450

Query: 126 TVYVELLPKNVNHSWIERVFGKCG--NVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAI 183
               + +P+ +    +      C    V+   +P  + T  P     VE E +E    A 
Sbjct: 451 R---KKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPP-----VEPEEEEDTEDA- 501

Query: 184 EFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDT 243
                         G+           A+   EE +K +  K  ++ ++N + +EE  + 
Sbjct: 502 --------------GL-------DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE 540

Query: 244 SNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDA 303
                   +      E    E  E  ++ S +K     ++     E+ +     S  +  
Sbjct: 541 EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRT 600

Query: 304 ESLAPRSKVKKIIQKDIIKEASEASKEN-RDIEISTEEEKDTGDLKDSSLLKTKRKHKKK 362
           +      K K+ I+K  ++ +   + E  R   I      DTG  K   L K +  H + 
Sbjct: 601 KEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTG--KTKILDKLRHTHVQD 658

Query: 363 HKE---RHKMGEEVIPLRVLSKSEWM 385
            +      ++G   +PL  +++   M
Sbjct: 659 GEAGGITQQIGATNVPLEAINEQTKM 684



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 26/120 (21%), Positives = 56/120 (46%), Gaps = 3/120 (2%)

Query: 8   QEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIE-KSRD 66
           +E+ +E+E  E+KK+ EK+++ R+K+    + K        A         + +E  S+D
Sbjct: 378 EEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKD 437

Query: 67  GYVDISLLVSFNKMKKL--TTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKDEDE 124
                  +    K KK+    + K ++ ++   A VE+  +G   + + P    P++E++
Sbjct: 438 SLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEED 497



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 68/362 (18%), Positives = 135/362 (37%), Gaps = 23/362 (6%)

Query: 237 KEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKK---KKKRDRVEASSLPEV-RT 292
           K ++ D++   I     +         +  EPQK   KK   KKK+D  E   L E+   
Sbjct: 6   KNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEEL 65

Query: 293 GKRKRSSSEDAESLAPR---SKVKKIIQKDIIKEASEASKENRDIEISTE-EEKDTGDLK 348
               +    D E++A +   +  ++   KD  K+  +  K++ D   S E E+KD+   K
Sbjct: 66  SLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKK 125

Query: 349 DSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQ 408
            +              + +K+ ++       S  +W   +++    +K    S   +  +
Sbjct: 126 TAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGE 185

Query: 409 IKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGR 468
              ES+    S   Q    KN+   N E     +  +     F    + +  + +    R
Sbjct: 186 SGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDAS-----FKIKTVAQKKAEKKERER 240

Query: 469 KQVRDTLAAISEVLYVDLLEGDTECHARFK------TPEDAQAVINAYTEINKKHCWKLE 522
           K+  +  A + ++   + LE   +  ++ K        E  ++ +   T +      K E
Sbjct: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE 300

Query: 523 ILSGDHEQRYWQKILVDRQAKLNQ----PREKKRGTEKLITKAEKIRLAKTQQASKHIRF 578
             +   +     K   D++ K  +     +EKK+G  K   KA +  LAK ++  +  + 
Sbjct: 301 TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR 360

Query: 579 SE 580
            E
Sbjct: 361 EE 362


>gi|61102725 la related protein isoform 2 [Homo sapiens]
          Length = 1096

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 34/84 (40%), Positives = 58/84 (69%), Gaps = 4/84 (4%)

Query: 32  KQVLAD-IAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLI 90
           +++L D I +Q++++F   NL +D FLR +++   DG++ I+L+ SF++++ LTTD  LI
Sbjct: 400 QELLKDYIKRQIEYYFSVDNLERDFFLRRKMDA--DGFLPITLIASFHRVQALTTDISLI 457

Query: 91  ARALRSSAVVELDLEGTRIRRKKP 114
             AL+ S VVE+  E  R RR++P
Sbjct: 458 FAALKDSKVVEIVDEKVR-RREEP 480


>gi|39725634 la related protein isoform 1 [Homo sapiens]
          Length = 1019

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 34/84 (40%), Positives = 58/84 (69%), Gaps = 4/84 (4%)

Query: 32  KQVLAD-IAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLI 90
           +++L D I +Q++++F   NL +D FLR +++   DG++ I+L+ SF++++ LTTD  LI
Sbjct: 323 QELLKDYIKRQIEYYFSVDNLERDFFLRRKMDA--DGFLPITLIASFHRVQALTTDISLI 380

Query: 91  ARALRSSAVVELDLEGTRIRRKKP 114
             AL+ S VVE+  E  R RR++P
Sbjct: 381 FAALKDSKVVEIVDEKVR-RREEP 403


>gi|118600973 RNA binding motif protein, X-linked 2 [Homo sapiens]
          Length = 322

 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 60/273 (21%), Positives = 103/273 (37%), Gaps = 28/273 (10%)

Query: 122 EDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAK 181
           +D   +++  LP  +    I  VF + G +V I++   K TG  KGF F+ +E +     
Sbjct: 33  KDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKKTGKSKGFCFLCYEDQRSTIL 92

Query: 182 AIEFLN-----------------NPPEEAPRKPGIFPKTVK-----NKPIPALRVVEEKK 219
           A++  N                   P+++     +  +  +       P P+L    E +
Sbjct: 93  AVDNFNGIKIKGRTIRVDHVSNYRAPKDSEEIDDVTRQLQEKGCGARTPSPSLSESSEDE 152

Query: 220 KKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEG-SDIESTEPQKQCSK---K 275
           K  KK  + KKE   + KE+          +   S P  +   + + T P+K  SK   +
Sbjct: 153 KPTKKHKKDKKEKKKKKKEKEKADREVQAEQPSSSSPRRKTVKEKDDTGPKKHSSKNSER 212

Query: 276 KKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIE 335
            +K +  E   LP+ RT       +ED E    + K K   +    +EA E     RD  
Sbjct: 213 AQKSEPREGQKLPKSRTA--YSGGAEDLERELKKEKPKHEHKSSSRREAREEKTRIRDRG 270

Query: 336 ISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHK 368
            S++      + +        R   +    RHK
Sbjct: 271 RSSDAHSSWYNGRSEGRSYRSRSRSRDKSHRHK 303


>gi|40353736 c-Mpl binding protein isoform c [Homo sapiens]
          Length = 653

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 75/346 (21%), Positives = 131/346 (37%), Gaps = 55/346 (15%)

Query: 38  IAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSS 97
           + KQ++F F   NL KD +L  Q++   D ++ I  + +  ++KKLTTD  LI   LRSS
Sbjct: 123 LKKQLEFCFSRENLSKDLYLISQMDS--DQFIPIWTVANMEEIKKLTTDPDLILEVLRSS 180

Query: 98  AVVELDLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVF--GKCGNVVYIS 155
            +V++D +G ++R                V +  +P+      ++ +F    C  V+   
Sbjct: 181 PMVQVDEKGEKVR---------PSHKRCIVILREIPETTPIEEVKGLFKSENCPKVISCE 231

Query: 156 IPHYKSTGDPKGFAFVEFETKEQAAKAIEFL-------NNPPEEAPRKPGIFPKTVKNKP 208
             H  +        ++ F++   A +A ++L          P  AP   G F     +  
Sbjct: 232 FAHNSNW-------YITFQSDTDAQQAFKYLREEVKTFQGKPIMAPFPNGSFVNGFNSPG 284

Query: 209 IPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSIS------------KMKRSRP 256
                       +  +K R+K +       E+    + S+               +R  P
Sbjct: 285 SYKTNAAAMNMGRPFQKNRVKPQFRSSGGSEHSTEGSVSLGDGQLNRYSSRNFPAERHNP 344

Query: 257 TSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSS-------EDAESLAPR 309
           T  G   E T  QK+ S  + +++         +  G+R+R            AES AP 
Sbjct: 345 TVTGHQ-EQTYLQKETSTLQVEQNGDYGRGRRTLFRGRRRREDDRISRPHPSTAESKAPT 403

Query: 310 SKVKKI------IQKDIIKEASEASKENR--DIEISTEEEKDTGDL 347
            K   +      +     +   E   ENR  D+     +EKD  +L
Sbjct: 404 PKFDLLASNFPPLPGSSSRMPGELVLENRMSDVVKGVYKEKDNEEL 449


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 40/159 (25%), Positives = 70/159 (44%), Gaps = 10/159 (6%)

Query: 213 RVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQC 272
           R  E ++++K+K+ R K+    + K+E          + K+ R   E    E  E +K+ 
Sbjct: 59  RKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENK--EGEEKEKRK 116

Query: 273 SKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENR 332
            K+KK+R R         R  +RKR   ++ E        +K  +++  +E  E  K  R
Sbjct: 117 KKEKKERGRTSKEGKERERKEERKREERKERE--------RKKEEREKERERKERKKRER 168

Query: 333 DIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGE 371
                 EEE+   + K+    +  RK +KK +ER +  E
Sbjct: 169 KQVGEKEEERKEKERKERKKRERNRKERKKERERKERRE 207



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 40/160 (25%), Positives = 77/160 (48%), Gaps = 10/160 (6%)

Query: 216 EEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKK 275
           E KK+++++K R ++++N + +E+          K +R R + EG + E  E +K+  +K
Sbjct: 89  ERKKEERERKKRRREKENKEGEEKE---KRKKKEKKERGRTSKEGKERERKEERKREERK 145

Query: 276 ---KKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQ---KDIIKEASEASK 329
              +KK +R +     E +  +RK+   ++ E      K +K  +   K+  KE     +
Sbjct: 146 ERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKER 205

Query: 330 ENRDIEISTEEEKDTGDLKD-SSLLKTKRKHKKKHKERHK 368
             R  E   +EE+     KD  +  + K + K++ KER K
Sbjct: 206 RERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 41/158 (25%), Positives = 75/158 (47%), Gaps = 21/158 (13%)

Query: 215 VEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSK 274
           + E++++ + +   KKE   + K+E  +       K KR R           E +++  K
Sbjct: 38  IREREREIETRKEGKKERESERKKERRERE-----KRKRER---------EKERKRERGK 83

Query: 275 KKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDI 334
           K+KK +R +     E R  K++R   E+ E    + K KK  +K+  + + E  +  R  
Sbjct: 84  KEKKGERKK-----EERERKKRRREKENKEG-EEKEKRKKKEKKERGRTSKEGKERERKE 137

Query: 335 EISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEE 372
           E   EE K+    K+    + +RK +KK +ER ++GE+
Sbjct: 138 ERKREERKERERKKEEREKERERKERKK-RERKQVGEK 174



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 36/133 (27%), Positives = 57/133 (42%), Gaps = 17/133 (12%)

Query: 241 MDTSNTSISKMKRSRP-TSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSS 299
           ++T    +S    S+P T  G   E  E +++   +K+ +   E+    E R  + KR  
Sbjct: 13  LNTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKE-RREREKRKR 71

Query: 300 SEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKH 359
             + E    R K +K  ++   KE  E  K  R+ E    EEK+            KRK 
Sbjct: 72  EREKERKRERGKKEKKGERK--KEERERKKRRREKENKEGEEKE------------KRK- 116

Query: 360 KKKHKERHKMGEE 372
           KK+ KER +  +E
Sbjct: 117 KKEKKERGRTSKE 129



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 26/129 (20%), Positives = 56/129 (43%), Gaps = 5/129 (3%)

Query: 176 KEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQ 235
           +E+  K  E      ++  ++ G   K  K +     R  EE+K++++KK   +KE   +
Sbjct: 102 REKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKE---R 158

Query: 236 AKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKR 295
            ++E        + + +  R   E  + +  E  ++  ++KK+R+R E     + R  K 
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRK--ERKKERERKERRERKKERKKKE 216

Query: 296 KRSSSEDAE 304
           +R      +
Sbjct: 217 ERKKERQKD 225



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 20/102 (19%), Positives = 49/102 (48%)

Query: 213 RVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQC 272
           R   E+KK++++K R +KE   + +++  +       K ++ R   E +  E  + +++ 
Sbjct: 144 RKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERK 203

Query: 273 SKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKK 314
            ++++K++R +     + R   R+ +  E       R + KK
Sbjct: 204 ERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245


>gi|222352111 MKI67 interacting nucleolar phosphoprotein [Homo
           sapiens]
          Length = 293

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 52/206 (25%), Positives = 88/206 (42%), Gaps = 35/206 (16%)

Query: 100 VELDLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHY 159
           VE   E  ++R++    ++ +      VYV  LP  ++ + I   F + G V    +   
Sbjct: 20  VEFQKEVAQVRKRITQRKKQEQLTPGVVYVRHLPNLLDETQIFSYFSQFGTVTRFRLSRS 79

Query: 160 KSTGDPKGFAFVEFETKEQAAKAIEFLNN-------------PPEEA----------PRK 196
           K TG+ KG+AFVEFE+++ A    E +NN             PPE+           P K
Sbjct: 80  KRTGNSKGYAFVEFESEDVAKIVAETMNNYLFGERLLECHFMPPEKVHKELFKDWNIPFK 139

Query: 197 PGIFPKTV---KNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKR 253
              +P      +N+ +     +EE+ KKK++  R K    +  K  + D  +  + K + 
Sbjct: 140 QPSYPSVKRYNRNRTLTQKLRMEERFKKKERLLRKK----LAKKGIDYDFPSLILQKTES 195

Query: 254 SRPTSEGSDIESTEPQKQCSKKKKKR 279
              T+       T  + Q  +KKKK+
Sbjct: 196 ISKTN-----RQTSTKGQVLRKKKKK 216


>gi|187960109 RNA binding motif protein 28 [Homo sapiens]
          Length = 759

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 69/295 (23%), Positives = 133/295 (45%), Gaps = 26/295 (8%)

Query: 67  GYVDISLLVSFNK-MKKLTT------DGKLIARALRSSAVVELDLEGTRIRRKKPLGERP 119
           GYV  S+L    + +K++TT      +  +  + LR+    +   E +   +K+P  ++ 
Sbjct: 48  GYVTFSMLEDVQRALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKA 107

Query: 120 KDEDERT-VYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQ 178
           K  D++  + +  L    +   ++ VF + G V+ ++IP  K  G  +GF FV+F+   +
Sbjct: 108 KVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPR-KPDGKMRGFGFVQFKNLLE 166

Query: 179 AAKAIEFLNNPPEEAPRKPGIFPKTVKN--KPIPALRVVEEKKKKK-------KKKGRMK 229
           A KA++ + N  E   R   +     K+  K   ++  + E+K  +       KKKGR  
Sbjct: 167 AGKALKGM-NMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGR-- 223

Query: 230 KEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIES--TEPQKQCSKKKKKRDRVEASSL 287
           +E++++ +E + D  +             E  +IES  T+P +   +  K+    ++S  
Sbjct: 224 EEEDMEEEENDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDH 283

Query: 288 PEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEK 342
            E  +   +  S +D E LA +S      Q+D  K    ++K+ R +     E K
Sbjct: 284 SEEDSDLEESDSIDDGEELA-QSDTSTEEQED--KAVQVSNKKKRKLPSDVNEGK 335



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 52/217 (23%), Positives = 88/217 (40%), Gaps = 32/217 (14%)

Query: 158 HYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEE 217
           H    G   G+AF EF+  E A KA+  +NN PE       IF      +PI     +E+
Sbjct: 532 HGNMKGQSLGYAFAEFQEHEHALKALRLINNNPE-------IFGPL--KRPIVEFS-LED 581

Query: 218 KKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKK 277
           ++K K K+ R+++                S+ KM RS+P +        EP K   +K  
Sbjct: 582 RRKLKMKELRIQR----------------SLQKM-RSKPATGEPQKGQPEPAKDQQQKAA 624

Query: 278 KRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEIS 337
           +    E S +P  +  K   +S    ++ A   +V+    K   K  +  S     I + 
Sbjct: 625 QHHTEEQSKVPPEQKRKAGSTSWTGFQTKAEVEQVELPDGKKRRKVLALPSHRGPKIRL- 683

Query: 338 TEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVI 374
               +D G +K     K K +  +  +E+ ++  E +
Sbjct: 684 ----RDKGKVKPVHPKKPKPQINQWKQEKQQLSSEQV 716



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 97/481 (20%), Positives = 186/481 (38%), Gaps = 64/481 (13%)

Query: 126 TVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEF 185
           T++V  LP +     +E +F + G V    +   K +   +GF +V F   E   +A++ 
Sbjct: 5   TLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKE 64

Query: 186 LNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSN 245
           +    E       +  K ++NK     +    +  KK+ K +  K   +  K+  +   N
Sbjct: 65  ITTF-EGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAK---VADKKARLIIRN 120

Query: 246 TSISKMKRSRPT---SEGSDIESTEPQKQCSKKK-----KKRDRVEAS------SLPEVR 291
            S    +    T     G+ +E   P+K   K +     + ++ +EA       ++ E++
Sbjct: 121 LSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIK 180

Query: 292 TG-------------KRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEIST 338
                          K  +S S   E  +  SK ++ ++K   +E     +EN D +   
Sbjct: 181 GRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDD 240

Query: 339 EEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKAS 398
           +EE    D +D      + K  K  + + +  +   P +    SE      E   L+++ 
Sbjct: 241 DEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSE------EDSDLEESD 294

Query: 399 MASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVK 458
                + ++Q  + +E + D  V  +   K +  ++  E +T              V ++
Sbjct: 295 SIDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKT--------------VFIR 340

Query: 459 IISTEPLPGRKQVRDTLAAISEVLYVDL-LEGDTE-----CHARFKTPEDAQAVINAYTE 512
            +S +     +++ + L    E+ YV + L  DTE       A+F T E AQ  + A + 
Sbjct: 341 NLSFD--SEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASP 398

Query: 513 INKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKK-RGTEKLITKAEKIRLAKTQQ 571
            N+    KL+      + +    +  D  AKL   + KK  GT  L    E +  A T+ 
Sbjct: 399 ENEAGGLKLD----GRQLKVDLAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKA 454

Query: 572 A 572
           A
Sbjct: 455 A 455


>gi|40353740 c-Mpl binding protein isoform b [Homo sapiens]
          Length = 730

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 46/176 (26%), Positives = 80/176 (45%), Gaps = 31/176 (17%)

Query: 38  IAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSS 97
           + KQ++F F   NL KD +L  Q++   D ++ I  + +  ++KKLTTD  LI   LRSS
Sbjct: 129 LKKQLEFCFSRENLSKDLYLISQMDS--DQFIPIWTVANMEEIKKLTTDPDLILEVLRSS 186

Query: 98  AVVELDLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVF--GKCGNVVYIS 155
            +V++D +G ++R                V +  +P+      ++ +F    C  V+   
Sbjct: 187 PMVQVDEKGEKVR---------PSHKRCIVILREIPETTPIEEVKGLFKSENCPKVISCE 237

Query: 156 IPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPA 211
             H  +        ++ F++   A +A ++L    EE         KT + KPI A
Sbjct: 238 FAHNSNW-------YITFQSDTDAQQAFKYLR---EEV--------KTFQGKPIMA 275


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 52/221 (23%), Positives = 93/221 (42%), Gaps = 24/221 (10%)

Query: 171 VEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTV--KNKPIPALRVVEEK-----KKKKK 223
           VE   K ++ + +    + P +   KP +  K V  K +P P    V EK     K K  
Sbjct: 574 VEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAA 633

Query: 224 KKGRMKKEDNIQA--KEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDR 281
           K+  +KKE  ++   K+E  +     ++K +   P  +    +  E +K+  K+ KK ++
Sbjct: 634 KEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEK 693

Query: 282 VEASS-----------LPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKE 330
            E                EV+  ++K    E+ E   P+ ++KK + KD  K ++  S+ 
Sbjct: 694 KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKE---PKKEIKK-LPKDAKKSSTPLSEA 749

Query: 331 NRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGE 371
            +   +  +  K    +K  S+   K K K K K   K G+
Sbjct: 750 KKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGK 790



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 53/242 (21%), Positives = 106/242 (43%), Gaps = 27/242 (11%)

Query: 214 VVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCS 273
           V +  K + K+K  +KK+  I+ + +   T     SK + S   +E ++ ++T+ + + +
Sbjct: 574 VEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAA 633

Query: 274 KKK--------KKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEAS 325
           K+K        K  D+ E    P+    K++  +    E    + +VKK ++K+I KE  
Sbjct: 634 KEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKE-- 691

Query: 326 EASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWM 385
           E  +  ++++  T  ++   ++K     + K++ K+  KE  K+ +              
Sbjct: 692 EKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPK-------------- 737

Query: 386 DLKKEYLALQKASM-ASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKV 444
           D KK    L +A   A+LK  +   K E  ++ DS        K +    ++E +  E V
Sbjct: 738 DAKKSSTPLSEAKKPAALKPKVP--KKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAV 795

Query: 445 NA 446
            A
Sbjct: 796 AA 797



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 44/197 (22%), Positives = 76/197 (38%), Gaps = 4/197 (2%)

Query: 251 MKRSRPTSEGSDIESTEPQKQC--SKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAP 308
           +K+++        ES +P  +   SK  +K  + E   + +V   ++        + +  
Sbjct: 530 VKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVK 589

Query: 309 RSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLL-KTKRKHKKKHKERH 367
           + K  K   K  + E    SKE      +   EK   D+K  +   KT +K  K   E  
Sbjct: 590 KDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDK 649

Query: 368 KMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTI-SQIKSESEMETDSGVPQNTG 426
           K  +E     V  K +   +KKE    ++     +KK I  + K E + E     P    
Sbjct: 650 KEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEV 709

Query: 427 MKNEKTANREECRTQEK 443
            K  K   ++E + +EK
Sbjct: 710 KKEVKKEEKKEVKKEEK 726



 Score = 37.7 bits (86), Expect = 0.029
 Identities = 105/517 (20%), Positives = 193/517 (37%), Gaps = 88/517 (17%)

Query: 2    ETESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKD---RFLR 58
            E E   +E   +E+ T  KKE EK K+  VK+ +    K+ +       + K+   + ++
Sbjct: 652  EKEKPKKEVAKKEDKTPIKKE-EKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVK 710

Query: 59   EQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGER 118
            ++++K     V         ++KKL  D K  +  L  +              KKP   +
Sbjct: 711  KEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEA--------------KKPAALK 756

Query: 119  PK-DEDERTVYVELL----PKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFV-- 171
            PK  + E +V  + +    PK      + +  GK    V  ++    +T      A +  
Sbjct: 757  PKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAA 816

Query: 172  -----EFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKG 226
                 E E +     + E L    EE   +     K +K    P L ++E+++K K+ + 
Sbjct: 817  IGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIK----PQLELIEDEEKLKETEP 872

Query: 227  -----RMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEG---------SDIESTEPQ--- 269
                   K+ +  +   E+ D   T+         T E           DIE  E +   
Sbjct: 873  VEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAG 932

Query: 270  -KQCSKKKKKRDRVEASSLPE--------VRTGKRKRSSSEDAESLAPRSKVKKIIQKDI 320
             ++ S+     ++ E     E        V     K S +ED ES    +      +++ 
Sbjct: 933  FEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRES 992

Query: 321  IKEASEASKENRDIEI------STEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVI 374
            +    + ++E+ D  I       +EEE D  D  + +        +++  E  KM  E  
Sbjct: 993  VASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDA--------REEEYEPEKMEAEDY 1044

Query: 375  PLRVLSK-SEWMDLKKEYLALQKASMASLKKTISQIKSESE-METDSGVPQNT---GMKN 429
             + V+ K +E    +++Y          L     Q+ ++S   E  S +   T   G ++
Sbjct: 1045 VMAVVDKAAEAGGAEEQY--------GFLTTPTKQLGAQSPGREPASSIHDETLPGGSES 1096

Query: 430  EKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLP 466
            E TA+ EE R  +    T     +   ++ IS+EP P
Sbjct: 1097 EATASDEENREDQPEEFTATSGYTQSTIE-ISSEPTP 1132


>gi|40353738 c-Mpl binding protein isoform a [Homo sapiens]
          Length = 724

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 28/73 (38%), Positives = 46/73 (63%), Gaps = 2/73 (2%)

Query: 38  IAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSS 97
           + KQ++F F   NL KD +L  Q++   D ++ I  + +  ++KKLTTD  LI   LRSS
Sbjct: 123 LKKQLEFCFSRENLSKDLYLISQMDS--DQFIPIWTVANMEEIKKLTTDPDLILEVLRSS 180

Query: 98  AVVELDLEGTRIR 110
            +V++D +G ++R
Sbjct: 181 PMVQVDEKGEKVR 193


>gi|238859597 RNA binding motif protein 34 isoform 1 [Homo sapiens]
          Length = 430

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 48/178 (26%), Positives = 84/178 (47%), Gaps = 22/178 (12%)

Query: 105 EGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGD 164
           +G RIR    L       D+R+V+V  LP  V  S IE+ F  CG+++ + I   K TG 
Sbjct: 269 DGFRIR--VDLASETSSRDKRSVFVGNLPYKVEESAIEKHFLDCGSIMAVRIVRDKMTGI 326

Query: 165 PKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVV-EEKKKKKK 223
            KGF +V FE  +    A++ LNN               +  + +  +R V +EK K++ 
Sbjct: 327 GKGFGYVLFENTDSVHLALK-LNN-------------SELMGRKLRVMRSVNKEKFKQQN 372

Query: 224 KKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEP--QKQCSKKKKKR 279
              R+K   N+   ++ ++ ++ +     +S    E + +  T+   QK+  + KK+R
Sbjct: 373 SNPRLK---NVSKPKQGLNFTSKTAEGHPKSLFIGEKAVLLKTKKKGQKKSGRPKKQR 427


>gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]
          Length = 237

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 49/188 (26%), Positives = 85/188 (45%), Gaps = 26/188 (13%)

Query: 205 KNKPIPALRVVEEKKKKKKKKGRMKKEDNI------------QAKEENMDTSNTSISKMK 252
           K K   AL   EEK  +  KK   K  + +            + K+E   +   S S   
Sbjct: 41  KKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSS 100

Query: 253 RSRPTSEGSDIESTEPQKQCSKKKKKRDR-----------VEASSLPEVRTGKRKRSSSE 301
            S  +S  SD E  E +KQ  ++KKK++R            E+ S   ++  K+ +  +E
Sbjct: 101 SSDSSSSSSDSED-EDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTE 159

Query: 302 DAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHK- 360
             + +   SK +K+  +D    +SE+  E+  IE    ++K + + ++ +  KTK+K K 
Sbjct: 160 KEKDIKGLSKKRKMYSEDK-PLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKH 218

Query: 361 KKHKERHK 368
           KKH ++ K
Sbjct: 219 KKHSKKKK 226



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 58/216 (26%), Positives = 89/216 (41%), Gaps = 20/216 (9%)

Query: 206 NKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIES 265
           N+P P    V+E+ +KKKK  +   E      EE M+  N      K       GS  ES
Sbjct: 25  NRPRPTWEEVKEQLEKKKKGSKALAEF-----EEKMN-ENWKKELEKHREKLLSGS--ES 76

Query: 266 TEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEAS 325
           +  ++Q  KK+KK+    +SS           S SED +    + + KK       K  S
Sbjct: 77  SSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKK-------KNRS 129

Query: 326 EASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPL--RVLSKSE 383
             S E+   E  ++ +      K S     K K  K   ++ KM  E  PL    LS+SE
Sbjct: 130 HKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESE 189

Query: 384 WMDLKKEYLALQKASMASLKKTISQIKSESEMETDS 419
           +++   E  A +K S    +K   + K + + +  S
Sbjct: 190 YIE---EVRAKKKKSSEEREKATEKTKKKKKHKKHS 222



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 29/118 (24%), Positives = 46/118 (38%), Gaps = 24/118 (20%)

Query: 216 EEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSR-------------------- 255
           ++ K++KKKK R  K       E   D S  S+ K K+S+                    
Sbjct: 117 KQGKRRKKKKNRSHKSSESSMSETESD-SKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYS 175

Query: 256 ---PTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRS 310
              P S  S  ES   ++  +KKKK  +  E ++    +  K K+ S +  +  A  S
Sbjct: 176 EDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 233



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 15/87 (17%)

Query: 218 KKKKKKKKGRMKKED------NIQAKEENMDTSNTSISKMK-------RSRPTSEGSD-- 262
           KKKKK K G  K++D        +   E+   S+ S+S+ +       + + +SE  +  
Sbjct: 149 KKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKA 208

Query: 263 IESTEPQKQCSKKKKKRDRVEASSLPE 289
            E T+ +K+  K  KK+ +  ASS P+
Sbjct: 209 TEKTKKKKKHKKHSKKKKKKAASSSPD 235


>gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]
          Length = 247

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 49/188 (26%), Positives = 85/188 (45%), Gaps = 26/188 (13%)

Query: 205 KNKPIPALRVVEEKKKKKKKKGRMKKEDNI------------QAKEENMDTSNTSISKMK 252
           K K   AL   EEK  +  KK   K  + +            + K+E   +   S S   
Sbjct: 51  KKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSS 110

Query: 253 RSRPTSEGSDIESTEPQKQCSKKKKKRDR-----------VEASSLPEVRTGKRKRSSSE 301
            S  +S  SD E  E +KQ  ++KKK++R            E+ S   ++  K+ +  +E
Sbjct: 111 SSDSSSSSSDSED-EDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTE 169

Query: 302 DAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHK- 360
             + +   SK +K+  +D    +SE+  E+  IE    ++K + + ++ +  KTK+K K 
Sbjct: 170 KEKDIKGLSKKRKMYSEDK-PLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKH 228

Query: 361 KKHKERHK 368
           KKH ++ K
Sbjct: 229 KKHSKKKK 236



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 58/216 (26%), Positives = 89/216 (41%), Gaps = 20/216 (9%)

Query: 206 NKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIES 265
           N+P P    V+E+ +KKKK  +   E      EE M+  N      K       GS  ES
Sbjct: 35  NRPRPTWEEVKEQLEKKKKGSKALAEF-----EEKMN-ENWKKELEKHREKLLSGS--ES 86

Query: 266 TEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEAS 325
           +  ++Q  KK+KK+    +SS           S SED +    + + KK       K  S
Sbjct: 87  SSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKK-------KNRS 139

Query: 326 EASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPL--RVLSKSE 383
             S E+   E  ++ +      K S     K K  K   ++ KM  E  PL    LS+SE
Sbjct: 140 HKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESE 199

Query: 384 WMDLKKEYLALQKASMASLKKTISQIKSESEMETDS 419
           +++   E  A +K S    +K   + K + + +  S
Sbjct: 200 YIE---EVRAKKKKSSEEREKATEKTKKKKKHKKHS 232



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 29/118 (24%), Positives = 46/118 (38%), Gaps = 24/118 (20%)

Query: 216 EEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSR-------------------- 255
           ++ K++KKKK R  K       E   D S  S+ K K+S+                    
Sbjct: 127 KQGKRRKKKKNRSHKSSESSMSETESD-SKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYS 185

Query: 256 ---PTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRS 310
              P S  S  ES   ++  +KKKK  +  E ++    +  K K+ S +  +  A  S
Sbjct: 186 EDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 15/87 (17%)

Query: 218 KKKKKKKKGRMKKED------NIQAKEENMDTSNTSISKMK-------RSRPTSEGSD-- 262
           KKKKK K G  K++D        +   E+   S+ S+S+ +       + + +SE  +  
Sbjct: 159 KKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKA 218

Query: 263 IESTEPQKQCSKKKKKRDRVEASSLPE 289
            E T+ +K+  K  KK+ +  ASS P+
Sbjct: 219 TEKTKKKKKHKKHSKKKKKKAASSSPD 245


>gi|40068059 CBF1 interacting corepressor [Homo sapiens]
          Length = 450

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 48/195 (24%), Positives = 92/195 (47%), Gaps = 16/195 (8%)

Query: 184 EFLNNPPEEAPRKPGIFPKTVKNKP--IPALRVVEEKKKKK-KKKGRMKKEDNIQAKEEN 240
           E++ +  EE P    +   T K K   +  L  +E+KKKKK +KK + +K  +   K ++
Sbjct: 198 EYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKS 257

Query: 241 MDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEA---SSLPEVRTGKRKR 297
             +S++S S    +  +   S+ ES   +K+  +KK+K+++      S   E    K+++
Sbjct: 258 SSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRK 317

Query: 298 SSSEDAESLAPRSKVK---KIIQKDIIKEASEASKENRDIEISTEE---EKDTGDLKDSS 351
              E + S   R K K   + ++ +  +E S+ S  + D +  T +   EK   + K+ S
Sbjct: 318 LHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGS 377

Query: 352 LLKTKRKHKKKHKER 366
                R H ++ + R
Sbjct: 378 ----SRSHGREERSR 388


>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
           [Homo sapiens]
          Length = 651

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 60/287 (20%), Positives = 117/287 (40%), Gaps = 24/287 (8%)

Query: 170 FVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMK 229
           + + +TK+ A K+ +  +   ++A +      K VK          ++KKK  KK     
Sbjct: 283 YTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKK---------DDKKKDVKKDTEST 333

Query: 230 KEDNIQAKEENMDTSNTS--ISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSL 287
             ++  +K+E  DT      + K  + + T +  +   TE       +   R+  +AS  
Sbjct: 334 DAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKN 393

Query: 288 PEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDL 347
            + +   +K + S D+ES        K  QKD  K+  ++  +N+   +  +EE    D 
Sbjct: 394 DDKKKDAKKITFSTDSES----ELESKESQKDEKKDKKDSKTDNKK-SVKNDEESTDADS 448

Query: 348 KDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWM----DLKKE--YLALQKASMAS 401
           +     K  +K +KK K+  K  ++    +  ++S  M    +LKK+  +   +K S   
Sbjct: 449 EPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKD 508

Query: 402 LKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATG 448
           +KK   +    ++ E D      TG K        +  ++E +   G
Sbjct: 509 IKKDARKDTESTDAEFDES--SKTGFKTSTKIKGSDTESEESLYKPG 553



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 56/234 (23%), Positives = 96/234 (41%), Gaps = 20/234 (8%)

Query: 235 QAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQ--KQCSKKKKKRDRVEASSLPEVRT 292
           Q   +N     T  +K    +   + SD ES + +  K+ SKK KK           V+ 
Sbjct: 270 QNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKN----------VKK 319

Query: 293 GKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEK---DTGDLK- 348
             +K+   +D ES    S   K  +KD  K+  +  K+++  +     E    ++GD K 
Sbjct: 320 DDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKD 379

Query: 349 ---DSSLLKTKRKHKKKHKERHKMGEEVIPLRVL-SKSEWMDLKKEYLALQKASMASLKK 404
              DS  LK   K+  K K+  K+         L SK    D KK+    +  +  S+K 
Sbjct: 380 ARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKN 439

Query: 405 TISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVK 458
                 ++SE + DS   +    K +K + +++ +   K NA   +  S + +K
Sbjct: 440 DEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELK 493



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 31/146 (21%), Positives = 61/146 (41%), Gaps = 10/146 (6%)

Query: 216 EEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKK 275
           +EKK KK  K   KK  +++  EE+ D  +      K+ +        +  + +K   K 
Sbjct: 421 DEKKDKKDSKTDNKK--SVKNDEESTDADSEPKGDSKKGKK-------DEKKGKKDSKKD 471

Query: 276 KKKRDRVEASSLPEVRTG-KRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDI 334
            KK+D  + +   E+ +  + K+      E    +  +KK  +KD     +E  + ++  
Sbjct: 472 DKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTG 531

Query: 335 EISTEEEKDTGDLKDSSLLKTKRKHK 360
             ++ + K +    + SL K   K K
Sbjct: 532 FKTSTKIKGSDTESEESLYKPGAKKK 557


>gi|27734775 hypothetical protein LOC286499 [Homo sapiens]
          Length = 248

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 41/166 (24%), Positives = 70/166 (42%), Gaps = 15/166 (9%)

Query: 217 EKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKK 276
           EK ++K   G        + K++    S  S S    S  +S  SD E  E +KQ  ++K
Sbjct: 74  EKSREKLLSGNESSSKKRERKKKRKKKSCRSSSSSSSSDSSSSSSDSEDEE-KKQGKRRK 132

Query: 277 KKRDRV-----------EASSLPEVRTGKRKRSSSE---DAESLAPRSKVKKIIQKDIIK 322
           KK++R            E+ S   V+  K+ +  +E   D  SL+ + K      K +  
Sbjct: 133 KKKNRSYKSSQSSTHESESESKESVKKKKKSKDETEKEKDVRSLSKKRKKSYPDDKPLSS 192

Query: 323 EASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHK 368
           E+S  S    D++   +   +  +     + K K+K  KKH ++ K
Sbjct: 193 ESSSESDYEEDVQAKKKRRCEEREQAKEKVKKKKKKQHKKHSKKKK 238



 Score = 36.2 bits (82), Expect = 0.085
 Identities = 43/212 (20%), Positives = 87/212 (41%), Gaps = 18/212 (8%)

Query: 206 NKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIES 265
           N+P P    V+++ + KK   +   E      EE M+ +     +  R +  S     ES
Sbjct: 35  NRPRPTWEEVKKQLENKKTGSKALAEF-----EEKMNENWKKELEKSREKLLSGN---ES 86

Query: 266 TEPQKQCSKKKKKRD-RVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEA 324
           +  +++  KK+KK+  R  +SS     +     S  E+ +    R K K    K      
Sbjct: 87  SSKKRERKKKRKKKSCRSSSSSSSSDSSSSSSDSEDEEKKQGKRRKKKKNRSYKSSQSST 146

Query: 325 SEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEW 384
            E+  E+++     ++ KD  + K+  +    +K KK + +   +  E       S SE 
Sbjct: 147 HESESESKESVKKKKKSKDETE-KEKDVRSLSKKRKKSYPDDKPLSSE-------SSSE- 197

Query: 385 MDLKKEYLALQKASMASLKKTISQIKSESEME 416
            D +++  A +K      ++   ++K + + +
Sbjct: 198 SDYEEDVQAKKKRRCEEREQAKEKVKKKKKKQ 229



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 22/93 (23%), Positives = 42/93 (45%), Gaps = 10/93 (10%)

Query: 216 EEKKKKKKKKGRMKKEDNIQA----------KEENMDTSNTSISKMKRSRPTSEGSDIES 265
           E  KKKKK K   +KE ++++           ++ + + ++S S  +      +    E 
Sbjct: 155 ESVKKKKKSKDETEKEKDVRSLSKKRKKSYPDDKPLSSESSSESDYEEDVQAKKKRRCEE 214

Query: 266 TEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRS 298
            E  K+  KKKKK+   + S   + ++G   +S
Sbjct: 215 REQAKEKVKKKKKKQHKKHSKKKKKKSGSSHKS 247



 Score = 30.0 bits (66), Expect = 6.1
 Identities = 25/108 (23%), Positives = 48/108 (44%), Gaps = 2/108 (1%)

Query: 191 EEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISK 250
           E+  +K G   K  KN+   + +    + + + K+   KK+ +    E+  D  + S  K
Sbjct: 121 EDEEKKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKKKKSKDETEKEKDVRSLS-KK 179

Query: 251 MKRSRPTSEGSDIEST-EPQKQCSKKKKKRDRVEASSLPEVRTGKRKR 297
            K+S P  +    ES+ E   +   + KK+ R E     + +  K+K+
Sbjct: 180 RKKSYPDDKPLSSESSSESDYEEDVQAKKKRRCEEREQAKEKVKKKKK 227


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 46/193 (23%), Positives = 80/193 (41%), Gaps = 15/193 (7%)

Query: 172 EFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKE 231
           E   KE+    ++    P E   ++P   PK  + +  PA    EEKK  KK++   K+ 
Sbjct: 813 EIPKKEEVKSPVKEEEKPQEVKVKEP---PKKAEEEKAPATPKTEEKKDSKKEEAPKKEA 869

Query: 232 DNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVR 291
              + +E+       ++ K K S+  ++  + E         KKK      EA +  EV+
Sbjct: 870 PKPKVEEKK----EPAVEKPKESKVEAKKEEAED--------KKKVPTPEKEAPAKVEVK 917

Query: 292 TGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSS 351
              + +  +E A+     +K K+  +    KEA+   K+ ++ +    EEK   + K   
Sbjct: 918 EDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977

Query: 352 LLKTKRKHKKKHK 364
             KT  K   K K
Sbjct: 978 DDKTLSKEPSKPK 990



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 46/180 (25%), Positives = 78/180 (43%), Gaps = 9/180 (5%)

Query: 172  EFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKE 231
            E E      K  E  ++  EEAP+K    PK  + K     +  E K + KK++   KK+
Sbjct: 843  EEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKK 902

Query: 232  DNIQAKEE--NMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKK----KKKRDRVEAS 285
                 KE    ++    +  K K      E  D ++ EP K   KK    +KK  + E +
Sbjct: 903  VPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA 962

Query: 286  SLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTG 345
              PE +  K +  + ED ++L+      K  + +  K +S   K+++  E +TE++   G
Sbjct: 963  KKPEEKP-KTEAKAKEDDKTLSKEPSKPKAEKAE--KSSSTDQKDSKPPEKATEDKAAKG 1019



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 53/266 (19%), Positives = 97/266 (36%), Gaps = 16/266 (6%)

Query: 165  PKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKK 224
            P+    ++ ++ E    A E   +P ++ P K     K     P  A   ++E  K  +K
Sbjct: 753  PEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEK 812

Query: 225  KGRMKKEDNIQAKEENMDTSNTSISKMKRSR----PTSEGSDIESTEPQKQCSKKKKKRD 280
            +   K+E     KEE            K++     P +  ++ +    +++  KK+  + 
Sbjct: 813  EIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP 872

Query: 281  RVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEE 340
            +VE    P V   K  +  ++  E+   +       +     E  E +K     E++ +E
Sbjct: 873  KVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKE 932

Query: 341  EKDTGDLKDSSLLKTKR---KHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKA 397
              D    + S   + K    + K   +E+ K  EE       +K +   L KE       
Sbjct: 933  PDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE------- 985

Query: 398  SMASLKKTISQIKSESEMETDSGVPQ 423
               S  K     KS S  + DS  P+
Sbjct: 986  --PSKPKAEKAEKSSSTDQKDSKPPE 1009



 Score = 30.0 bits (66), Expect = 6.1
 Identities = 31/122 (25%), Positives = 49/122 (40%), Gaps = 7/122 (5%)

Query: 160  KSTGDPKGFAFVEFETKEQAA--KAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEE 217
            K    P+  A  + E KE A   +  E     P++A  K    P   K          EE
Sbjct: 901  KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960

Query: 218  KKKKKKKKGRMKKEDNIQAKEENMDTS-NTSISKMKRSRPTSEGSDIESTEPQKQCSKKK 276
            K KK ++K + +     +AKE++   S   S  K +++  +S     +S  P+K    K 
Sbjct: 961  KAKKPEEKPKTE----AKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKA 1016

Query: 277  KK 278
             K
Sbjct: 1017 AK 1018


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 66/305 (21%), Positives = 121/305 (39%), Gaps = 57/305 (18%)

Query: 190 PEEAPRKPGIFPKTVKNKPIPALRVVEEK-----KKKKKKKGRMKKEDNIQAKEENMDTS 244
           P ++P  P   P    ++P PA   +EEK     K +KK     KK++    K+++   +
Sbjct: 284 PGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKET 343

Query: 245 NTSISKMK--RSRPTSEGS----------------DIESTEPQKQCSKKKKKRDRVEASS 286
              + K +  ++  T +G+                D + T+   +  + K K+   +   
Sbjct: 344 AIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKH 403

Query: 287 LPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGD 346
           +   ++ K++ S   D +  A   + K+ I    IK+A    KE +  +   +E +    
Sbjct: 404 VEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKS 463

Query: 347 LKDSSLLKTKRKHK-----------------KKHKERHKMGEEVIPL--RVLSKSEWM-- 385
            K SS+LK K   K                 KK ++  K G+EV P   ++  K E    
Sbjct: 464 GKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPE 523

Query: 386 -DLKK-------EYLALQKASMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREE 437
             +KK       E + + K  +   +KT+S  K E ++     + Q   +  EKTA  + 
Sbjct: 524 PQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKV-----LKQVKAVTIEKTAKPKP 578

Query: 438 CRTQE 442
            +  E
Sbjct: 579 TKKAE 583



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 52/296 (17%), Positives = 117/296 (39%), Gaps = 19/296 (6%)

Query: 191 EEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISK 250
           +E P K     + ++ K  P  + + +++KK K   + +++   + K    +    + +K
Sbjct: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAK 236

Query: 251 MKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRT-GKRKRSSSEDAESLAPR 309
           +K  + T      +  + +   SK ++K        + ++   G  K   S       P 
Sbjct: 237 VKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPT 296

Query: 310 SKVKKIIQKDIIKEASEASKENRDIEISTE-EEKDTGDLKDSSLLKTKRKHKKKH---KE 365
            +  +        E  E  K+  + ++++E ++K+  D+K  S  +T    +KK      
Sbjct: 297 EQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKAS 356

Query: 366 RHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSGVPQNT 425
             K G   I  +  +K +  + K++    +K +     K   Q K E  +E      +  
Sbjct: 357 ETKQGTVKIAAQAAAKKD--EKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEH 414

Query: 426 GMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISEV 481
            + ++K    +  R +E++ A        V +K    + +PG+K+ + T     E+
Sbjct: 415 SVPSDKQVKAKTERAKEEIGA--------VSIK----KAVPGKKEEKTTKTVEQEI 458



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 60/269 (22%), Positives = 101/269 (37%), Gaps = 49/269 (18%)

Query: 210 PALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQ 269
           P LR  E  K K +K+   K E  IQ K  + +         ++ +P  + +  E  E +
Sbjct: 136 PPLRKKEIHKDKTEKQE--KPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKK 193

Query: 270 KQCS--------KKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDII 321
           ++          KK K  ++ E  +  EV+ GK+++     A       KVK+ +QK   
Sbjct: 194 EKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAA-------KVKE-VQKTPS 245

Query: 322 KEASEASKENRDIEISTEEEKDT-------------GDLK-------------DSSLLKT 355
           K   +  KE     +S  E+KD              GDLK             + +   T
Sbjct: 246 KPKEKEDKEK--AAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPT 303

Query: 356 KRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEM 415
                 + KE  K   E        K E  D+KK+    +K +   ++K      SE++ 
Sbjct: 304 PASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKK---SEKETAIDVEKKEPGKASETKQ 360

Query: 416 ETDSGVPQNTGMKNEKTANREECRTQEKV 444
            T     Q    K+EK  + ++ +   +V
Sbjct: 361 GTVKIAAQAAAKKDEKKEDSKKTKKPAEV 389



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 82/386 (21%), Positives = 158/386 (40%), Gaps = 32/386 (8%)

Query: 12  MEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDI 71
           +EE+  EKKK  +K      K+   DI K+ +    +  +  ++    +  +++ G V I
Sbjct: 309 LEEKEGEKKKAEKKVTSETKKKEKEDIKKKSE---KETAIDVEKKEPGKASETKQGTVKI 365

Query: 72  SLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKDEDERTVYVEL 131
           +   +  K +K     K  ++  +  A VE      + +++K +      + E +V  + 
Sbjct: 366 AAQAAAKKDEK-----KEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDK 420

Query: 132 LPKNVNHSWIERVFGKCGNV-VYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPP 190
             K    +  ER   + G V +  ++P  K   + K    VE E +++ +     +    
Sbjct: 421 QVK----AKTERAKEEIGAVSIKKAVPGKK---EEKTTKTVEQEIRKEKSGKTSSILKDK 473

Query: 191 EEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISK 250
           E    K    P ++K K  P  +  +++K  K  K    K   +Q K+E           
Sbjct: 474 EPIKGKEEKVPASLKEKE-PETK--KDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIK--- 527

Query: 251 MKRSRPT-SEGSDI---ESTEPQKQCSK-KKKKRDRVEASSLPEVRTGKRKRSSSEDAES 305
            K ++P  SE   I   +  +P+K  S  K +++   +  ++   +T K K +   +   
Sbjct: 528 -KEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRE 586

Query: 306 LAPRSKVKKIIQKDIIKEASEASKE-NRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHK 364
             P S +K    K   K  SE ++   +  EIS +E K+  D+K   L + K   +K+  
Sbjct: 587 REPPS-IKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMK--HLREEKVSTRKESL 643

Query: 365 ERHKMGEEVIPLRVLSKSEWMDLKKE 390
           + H + +   P RV    E +   K+
Sbjct: 644 QLHNVTKAEKPARVSKDVEDVPASKK 669


>gi|54112403 chromodomain helicase DNA binding protein 7 [Homo
           sapiens]
          Length = 2997

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 64/287 (22%), Positives = 119/287 (41%), Gaps = 33/287 (11%)

Query: 185 FLNNPPEEAPRKPGIFPKTVKNKP-IPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDT 243
           FL  P  +  +  G   + VK+   +P++    ++KKKKKK   +  ED   +K    D 
Sbjct: 562 FLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIVAED--PSKGFGKDD 619

Query: 244 SNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDA 303
               +   + +R + +GS  E         KKKKKR + +     + +  K  +   E  
Sbjct: 620 FPGGVDNQELNRNSLDGSQEE---------KKKKKRSKAK----KDPKEPKEPKEKKEPK 666

Query: 304 ESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKH 363
           E   P  K  KI ++   K+A  A+ + +  + S+ ++ D+   + S+L K   K K + 
Sbjct: 667 EPKTP--KAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDS---EASALKKKVNKGKTEG 721

Query: 364 KERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSGVPQ 423
            E   + +   P     + E   ++K   + Q       +    +I  E   + D+    
Sbjct: 722 SENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAA--- 778

Query: 424 NTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQ 470
                 +  +N  +   QE V+A GP     V+ KI+S+  +  +K+
Sbjct: 779 ----GRDSPSNTSQSEQQESVDAEGP-----VVEKIMSSRSVKKQKE 816



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 58/235 (24%), Positives = 97/235 (41%), Gaps = 27/235 (11%)

Query: 172 EFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKE 231
           E + K++ +KA +    P E   +K    PKT K   IP     +E K+KK K    K +
Sbjct: 639 EEKKKKKRSKAKKDPKEPKEPKEKKEPKEPKTPKAPKIP-----KEPKEKKAKTATPKPK 693

Query: 232 DNIQAKEENMDTSNTSISKMKRSRPT--SEGSDIESTEPQKQCSKKKKKRDRVEASSLPE 289
            + ++  +  D+  +++ K      T  SE SD++ T P     ++ +     +  S  +
Sbjct: 694 SSKKSSNKKPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQ 753

Query: 290 VRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKD 349
           V   KRKR  +ED E             K   +EA +A    RD   +T + +    +  
Sbjct: 754 V---KRKR-YTEDLEF------------KISDEEADDADAAGRDSPSNTSQSEQQESVDA 797

Query: 350 SSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKK 404
              +  K    +  K++ + GEEV       K +       YL  Q AS+  L+K
Sbjct: 798 EGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYK----NFSYLHCQWASIEDLEK 848


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 54/201 (26%), Positives = 91/201 (45%), Gaps = 14/201 (6%)

Query: 229 KKEDNIQAKEENMDTSNTSISKM-KRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSL 287
           K +    +KE    T+ T++SK+ KR     EG+    +E  K+ +K +KK    E+S  
Sbjct: 312 KIKQRADSKESLKATTKTAVSKLAKREEVVEEGAKEARSELAKELAKTEKKAK--ESSEK 369

Query: 288 PEVRTGKRKRSSSEDAESLAP--RSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTG 345
           P  +  K +R  +E +E+L    R  +K  + K  +KE     +E +D E   E +K+  
Sbjct: 370 PPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEKISKLEEKKDKE-KKEIKKERK 428

Query: 346 DLK-DSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEY-LALQKASMASLK 403
           +LK D    + K+  KK+ K +    E    L+ +SK +      E    L KA +    
Sbjct: 429 ELKKDEGRKEEKKDAKKEEKRKDTKPE----LKKISKPDLKPFTPEVRKTLYKAKVPGRV 484

Query: 404 K--TISQIKSESEMETDSGVP 422
           K      I+ E E+ ++   P
Sbjct: 485 KIDRSRAIRGEKELSSEPQTP 505



 Score = 32.7 bits (73), Expect = 0.94
 Identities = 32/188 (17%), Positives = 79/188 (42%), Gaps = 22/188 (11%)

Query: 176 KEQAAKAIEFLNNPPEEAPRKPGIFP--------KTVKNKPIPALRVVEEKKKKKKKKGR 227
           + +A +  + L++ P+  P + G  P        + V + P    +  EE K++++    
Sbjct: 488 RSRAIRGEKELSSEPQTPPAQKGTVPLPTISGHRELVLSSPEDLTQDFEEMKREERALLA 547

Query: 228 MKKEDNIQAKEENMDTSNT------------SISKMKRSRPTSEGSDIESTEPQKQCSKK 275
            +++  +  K   +DT+              S+  + +     +  ++    P++Q SK 
Sbjct: 548 EQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSVPGLGQEEHVMKEKELVPEVPEEQGSKD 607

Query: 276 KKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIE 335
           +      E     +    K++R +    +    R + +  +++D+I++A    +E  ++ 
Sbjct: 608 RGLDSGAETEEEKDTWEEKKQREAERLPDRTEAREESEPEVKEDVIEKAE--LEEMEEVH 665

Query: 336 ISTEEEKD 343
            S EEE+D
Sbjct: 666 PSDEEEED 673


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 89/414 (21%), Positives = 177/414 (42%), Gaps = 58/414 (14%)

Query: 7    NQEKVMEEE---STEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEK 63
            ++ K+ +EE   +  K+    K++R  ++Q   DI K+ DF    + L KD   ++   K
Sbjct: 2086 DERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDI-KEWDFSEKRSELTKDE--KKLARK 2142

Query: 64   SRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGT--------------RI 109
             R     +  ++  NK +K+T +   +AR   S  +++ + EG               R 
Sbjct: 2143 QRKLANKMRRMI--NKEEKMTEEESKLARK-HSEVILDDEEEGGIEEEEVIPFLKRRWRK 2199

Query: 110  RRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFA 169
            R++   G++PK++             V+    E  F +    +   +   +S    +   
Sbjct: 2200 RKEAKRGDKPKEK---------FSSQVDEVESEEHFSEEMESLLDELEKQESLSSEE--- 2247

Query: 170  FVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMK 229
              E E +E+  +  E +    EE   +     K V+ +        EE+KKKKKK+   K
Sbjct: 2248 --EEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKE--------EEEKKKKKKE---K 2294

Query: 230  KEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSK-----KKKKRDRVEA 284
            K++ +Q KEE  +     +S+ +    + E  + ES   +++  +     KK+K+ +++ 
Sbjct: 2295 KKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQE 2354

Query: 285  SSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDT 344
                 +R  +R  S          R+    +++  + K  S A +      +   E++ +
Sbjct: 2355 QRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQIS 2414

Query: 345  GDLKDSSLLKTKRKH-KKKHKERHKMGE-EVIPLRVLS---KSEWMDLKKEYLA 393
             + K +++++  RK      KER  MG+ E IP  VL    +S+  DLK  +++
Sbjct: 2415 WEDKKATVVEIPRKFLGTMDKEREVMGKYEPIPPHVLGTVLESQAQDLKTPFMS 2468



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 77/380 (20%), Positives = 160/380 (42%), Gaps = 44/380 (11%)

Query: 216  EEKKKKKKKKGRMKKEDNIQAKEENM--------DTSNTSISKMKRSRPTSEGSDIESTE 267
            E +K  +K+K   KK + +  +EE +        +  N    K++      +  D +  E
Sbjct: 1654 EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE 1713

Query: 268  PQKQCSKKKKKRDRV----EASSLPEVRTGKRKRSSSEDAESLA-PRSKVK----KIIQK 318
              ++  + +   + +    E  +  E +  + K+  +E+ E+LA  R K+     K+ Q+
Sbjct: 1714 LAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQE 1773

Query: 319  D--IIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPL 376
            +  +I+E  + ++     E   EEE+  G  ++  + K  +  +K+ +  + M E     
Sbjct: 1774 EELLIQEKEKLAQHK---EKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEE----- 1825

Query: 377  RVLSKSEWMDLKKEYLALQKASMASLKKTISQIKS----ESEMETDS-----GVPQNTGM 427
              L+K++ +  +K+ LA +K ++A  K+ ++Q K       E  T S      V    GM
Sbjct: 1826 --LTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGM 1883

Query: 428  KNEKTANREECRTQEKVNA-TGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISEVLYVDL 486
             N+  A  EE  TQEK       + ++    K++  E    +KQ +     +   L   +
Sbjct: 1884 FNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAM 1943

Query: 487  LEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQ 546
            ++G           ++ +A+     E+ +    K+ ++ G       +     RQ K+ Q
Sbjct: 1944 VQGKKRLRGELDIAKEEKAL---NLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQ 2000

Query: 547  PREKKRGTEKLITKAEKIRL 566
              ++    E+ ++  EKI L
Sbjct: 2001 VEQEL--FERKLSLEEKILL 2018



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 41/215 (19%), Positives = 95/215 (44%), Gaps = 27/215 (12%)

Query: 218  KKKKKKKKGRMKKE------DNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQ 271
            +K+K+ K+G   KE      D ++++E   +   + + ++++    S     E  E +++
Sbjct: 2198 RKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSS----EEEEEREE 2253

Query: 272  CSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKEN 331
              +++++  R E     E   G+ K+   E+ E    + K KK  +K+ ++E  E  +E 
Sbjct: 2254 EEEREEEEVREEEEERKEEEEGEEKQVEKEEEE----KKKKKKEKKKEEVQEKEEVFEEK 2309

Query: 332  RDI-------EISTEEEKDTGDL------KDSSLLKTKRKHKKKHKERHKMGEEVIPLRV 378
             +I        +S EEE++          ++  +LK +++ K + + R  +      L +
Sbjct: 2310 EEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSI 2369

Query: 379  LSKSEWMDLKKEYLALQKASMASLKKTISQIKSES 413
            L        +   L + K+ +  L  T  ++K ++
Sbjct: 2370 LRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKT 2404



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 30/109 (27%), Positives = 55/109 (50%), Gaps = 8/109 (7%)

Query: 274  KKKKKRDRVEASSLPEVRTGKRKRSSS----EDAESLAPRSKVKKIIQ--KDIIKEASEA 327
            KK K+RD  + S+ P +   +    ++    E+A   +  S    +I+  KD+  +  + 
Sbjct: 1101 KKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDI 1160

Query: 328  SKENRDIEISTEEE-KDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIP 375
            SK++  + +   ++ +D  D K ++  K K+KHKKK KE   + EE  P
Sbjct: 1161 SKDHIALTLKRLQKIRDKRD-KKATAQKLKKKHKKKGKEAKVINEETTP 1208



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 86/429 (20%), Positives = 164/429 (38%), Gaps = 55/429 (12%)

Query: 202  KTVKNKPIPALRVVE-EKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEG 260
            KT +  P    + V+ E+K  K K+   K+E ++  + E M T    + K +      E 
Sbjct: 1394 KTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIER 1453

Query: 261  S-----------DIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPR 309
            +           + +    + + S K  K +  +     E +  +     S + E L   
Sbjct: 1454 TPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQED 1513

Query: 310  SKVK----KIIQKDIIKEASEASKENRDIEISTEEE-KDTGDLKDSSLLKTKRKHKKKHK 364
             K+K    K + ++++   S+  +   + E++ EEE    G+ K+  + + +R  +++HK
Sbjct: 1514 KKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHK 1573

Query: 365  -----------ERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSES 413
                       E+ +  EE    ++  + E +  ++  LA ++  +A     I+Q   E 
Sbjct: 1574 WARIHRKRARAEKKRAQEE---RKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREM 1630

Query: 414  EM----------------ETDSGVPQNTGMKNEKTANREE--CRTQEKVNATGPQFVSGV 455
                              E  S   +    K +K A + E   R +EK+   G +     
Sbjct: 1631 AQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVK 1690

Query: 456  IVKIISTEPLPGRKQVRD----TLAAISEVLYVDLLEGDTECHARFKTPEDAQAVINAYT 511
             +     E LP R+Q  D     LA   E L  D+ E   +     +             
Sbjct: 1691 NILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLA 1750

Query: 512  EINKKHCWKLEILSGDHEQ-RYWQKILVDRQAKLNQPREK-KRGTEKLITKAEKIRLAKT 569
            E  +   W+ E LS +  +    +++L+  + KL Q +EK     E+L  K E++   K 
Sbjct: 1751 EEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKM 1810

Query: 570  QQASKHIRF 578
            + A K  R+
Sbjct: 1811 KLAQKRERW 1819



 Score = 30.0 bits (66), Expect = 6.1
 Identities = 13/26 (50%), Positives = 19/26 (73%)

Query: 2    ETESGNQEKVMEEESTEKKKEVEKKK 27
            E E G +++V +EE  +KKK+ EKKK
Sbjct: 2271 EEEEGEEKQVEKEEEEKKKKKKEKKK 2296



 Score = 29.6 bits (65), Expect = 8.0
 Identities = 80/379 (21%), Positives = 163/379 (43%), Gaps = 46/379 (12%)

Query: 216  EEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKK 275
            ++ KKK KKKG+  K  N +     M+   T   K+ + R  S  S   ST      S  
Sbjct: 1186 QKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKI-QGRGASGISGRRSTAGDG--SSW 1242

Query: 276  KKKRDRVEASSLPEVRTGKRKRSSSE----DAESLAPRSKVKKIIQK--DIIKEASEASK 329
            +    R+ A  +   +T   +  ++E      E L  R    ++ Q+   ++K+ S+   
Sbjct: 1243 RDDLCRLMALRISGSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLL 1302

Query: 330  ENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKK 389
            E+ D ++   E+K    +++ ++ +   +   +   RHK   EV+P            ++
Sbjct: 1303 EDLDWDVVPPEKKPI-FIQEGAIREDMIQGVTQEVIRHK---EVMP------------RE 1346

Query: 390  EYLALQKA-SMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATG 448
            E  A +KA  M  L++T  Q+  +   +     P N  M  E  + +EE +T +K    G
Sbjct: 1347 EEQAQKKARDMLGLEET--QVILKKGKKVIFLEPGNVTMGKE-ISKKEEKKTFQKSPKQG 1403

Query: 449  PQFVS-----GVIVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHARFKTPEDA 503
             + V      G I + ++ E     ++V + +A + E +     EG      R  + +D 
Sbjct: 1404 RKAVQKERKVGKIKREMTKEERDMSEEVEE-MATLEEKVVKQ--EGKLVMIERTPSWQDW 1460

Query: 504  QAVINAYTEIN--KKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKA 561
            +   + + +++   +  WK         +  W+K L+  + KL+Q  EK    E+++ + 
Sbjct: 1461 KKAWDEWKQVHGETRKSWKA-------WKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQED 1513

Query: 562  EKIRLAKTQQASKHIRFSE 580
            +K++  + +Q  +++  S+
Sbjct: 1514 KKLKWEEWKQVWENMLSSK 1532


>gi|87299628 biorientation of chromosomes in cell division 1-like
           [Homo sapiens]
          Length = 3051

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 53/229 (23%), Positives = 98/229 (42%), Gaps = 36/229 (15%)

Query: 215 VEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSK 274
           +EEK+K+K +K +  K         +++ S+T   + K +R      + +  E +   SK
Sbjct: 515 LEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSK 574

Query: 275 KKKKRDR-VEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRD 333
           K+KK  R VE +S       K+K+   ED++     S+  +       KE   +SKE + 
Sbjct: 575 KRKKDSRNVEENS-------KKKQQYEEDSKETLKTSEHCE-------KEKISSSKELKH 620

Query: 334 IEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHK--MGEEVIPLRVLSKSEWMDLKKEY 391
           +   +E  K    L +S  +  + K++ K +  HK      VI   V  +++  D+K++ 
Sbjct: 621 VHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQV 680

Query: 392 LALQKASMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRT 440
                                SE+ T+    Q + +KNEK   +++  T
Sbjct: 681 -------------------ERSEICTEEPQKQKSTLKNEKHLKKDDSET 710



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 53/279 (18%), Positives = 116/279 (41%), Gaps = 32/279 (11%)

Query: 174 ETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKK--------KKK 225
           +TK Q   +++   +  +    K     + +K + +   +V   KK+KK         KK
Sbjct: 530 KTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKK 589

Query: 226 GRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCS-----------K 274
            +  +ED+ +  + +       IS  K  +     S  E ++P ++ S           +
Sbjct: 590 KQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKS--EPSKPARRLSESLHVVDENKNE 647

Query: 275 KKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDI 334
            K +R+    +S P +  G ++ + + D +    RS   +I  ++  K+ S    E    
Sbjct: 648 SKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERS---EICTEEPQKQKSTLKNEKH-- 702

Query: 335 EISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKM-GEEVIPLRVLSKSEWMDLKKEYLA 393
               +++ +T  LK  SLLK + K  K+  ER K   E+ + ++   K + M    +   
Sbjct: 703 --LKKDDSETPHLK--SLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETE 758

Query: 394 LQKASMA-SLKKTISQIKSESEMETDSGVPQNTGMKNEK 431
           L  +     +++ I +   ++++ +D    + +  +NE+
Sbjct: 759 LHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNER 797



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 37/164 (22%), Positives = 78/164 (47%), Gaps = 15/164 (9%)

Query: 222  KKKKGRMKK---EDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKK 278
            K+K+GR +K   E  ++ K+++   ++T I  +++S  +S+   +++ E  K+ +  +++
Sbjct: 2872 KRKRGRPRKYPVETTLKMKDDSK--TDTGIVTVEQSPSSSKLKVMQTDESNKETANLQER 2929

Query: 279  -------RDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKEN 331
                    +++  S     R  KR  + S+DAES  P  K +K +   +  +  + S E 
Sbjct: 2930 SISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEE 2989

Query: 332  RDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIP 375
             + E   EE++ +G    S+     ++ K +     K   EV P
Sbjct: 2990 EEEE---EEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSP 3030



 Score = 38.1 bits (87), Expect = 0.022
 Identities = 52/237 (21%), Positives = 100/237 (42%), Gaps = 32/237 (13%)

Query: 236 AKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKR 295
           A   + +TSN   S+    +  S+ +   ST+ ++       K      S    + T  +
Sbjct: 217 AARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPK 276

Query: 296 KRSSSEDAESLAPRSKVKK---------IIQKDIIKEASEASKENRDIEISTEEEKDTGD 346
              S E ++   P  ++K          ++ KD+ +E+SE   ++ D      +  + G+
Sbjct: 277 ---SEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGE 333

Query: 347 LKDSSLLKTKRK--HKKKHKERHKMGE-------EVIPLRVLS-----KSEWMDLKKEYL 392
            K     KT++K  H KK ++  K+ +       EV  L++ S     K++ ++  KE  
Sbjct: 334 RKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDF 393

Query: 393 ALQKASMASLKK-TISQIK----SESEMETDSGVPQNTGM-KNEKTANREECRTQEK 443
           +L  + +  L   T+S +     S  E +T+  V  +  M + E T++ EE   Q K
Sbjct: 394 SLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNK 450



 Score = 37.7 bits (86), Expect = 0.029
 Identities = 56/296 (18%), Positives = 103/296 (34%), Gaps = 61/296 (20%)

Query: 172 EFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKE 231
           E + ++   K  + L     E P    +  K VK+             K+K ++ +   E
Sbjct: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSS------------KEKPEREKTPSE 736

Query: 232 DNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVR 291
           D +  K +                 + +G  +E    ++    K    D+ E        
Sbjct: 737 DKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTE-------- 788

Query: 292 TGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSS 351
               ++S   +   L+   K  K + + IIK      KEN   E     E          
Sbjct: 789 ----RKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAE---------- 834

Query: 352 LLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKS 411
             KTK +HK +     K+           + + +  K+  + LQ+          S+  S
Sbjct: 835 --KTKAEHKSRRSSDSKI-----------QKDSLGSKQHGITLQRR---------SESYS 872

Query: 412 ESEMETDSGVPQNTGMKNEKTANREECRT----QEKVNATGPQFVSGVIVKIISTE 463
           E + + DS    ++ +K E+  ++E+ RT    +EK+         G  VK++ TE
Sbjct: 873 EDKCDMDS-TNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETE 927



 Score = 33.9 bits (76), Expect = 0.42
 Identities = 81/423 (19%), Positives = 154/423 (36%), Gaps = 44/423 (10%)

Query: 176 KEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKK----- 230
           K+   ++ E  N   ++  +KP    K  + K        E+K+K +KK    KK     
Sbjct: 305 KDVQQESSEQKNKSTDKGEKKPDSNEKGERKK--------EKKEKTEKKFDHSKKSEDTQ 356

Query: 231 --EDNIQAKEENMDTSNTSISKMKRSRPTSEG---------SDIESTEPQKQCSKKKKKR 279
             +D  QAKE+ +++      K      T EG         SD++        S      
Sbjct: 357 KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDL 416

Query: 280 DRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTE 339
              E  +  EV T          ++      + K   Q     E    S  +  +     
Sbjct: 417 SSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYL 476

Query: 340 EEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASM 399
             K   D  D   ++ +R+   K KE   +  ++         E ++ K++    QKA  
Sbjct: 477 YSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQI-------NREKLEEKRK----QKAEK 525

Query: 400 ASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKI 459
               KT  Q +S  ++E  S           K   +E    ++KV  +  +      V+ 
Sbjct: 526 TKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEE 585

Query: 460 ISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTE---CHARFKTPEDAQAVINAYTEINK- 515
            S +     +  ++TL   SE    + +    E    HA+ +  + A+ +  +   +++ 
Sbjct: 586 NSKKKQQYEEDSKETLKT-SEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDEN 644

Query: 516 KHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKL-ITKAEKIRLAKTQQASK 574
           K+  KLE    +H++R    ++++   +    R+ KR  E+  I   E  +   T +  K
Sbjct: 645 KNESKLE---REHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEK 701

Query: 575 HIR 577
           H++
Sbjct: 702 HLK 704



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 48/260 (18%), Positives = 94/260 (36%), Gaps = 35/260 (13%)

Query: 214  VVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIE--------- 264
            V EE++   K+K +     +    ++N D  ++ I   +R  P +E  D +         
Sbjct: 2761 VEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEE 2820

Query: 265  ----STEPQKQCSKKKKKRDRVEASSL----PEVRTGKRKRSSSEDAESLAPRS------ 310
                S+E     S+  +++D   +S      PE       +S  ED   +  R       
Sbjct: 2821 LPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRK 2880

Query: 311  -------KVKKIIQKD--IIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKK 361
                   K+K   + D  I+      S     +  + E  K+T +L++ S+     + K 
Sbjct: 2881 YPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKI 2940

Query: 362  KHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSGV 421
                R +  +   P R L+ S+  +  +     QK+    ++    Q   E E E +   
Sbjct: 2941 VTSVRRRGRK---PKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDE 2997

Query: 422  PQNTGMKNEKTANREECRTQ 441
            P     ++   +  +  +TQ
Sbjct: 2998 PSGATTRSTTRSEAQRSKTQ 3017


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 41/164 (25%), Positives = 73/164 (44%), Gaps = 19/164 (11%)

Query: 215 VEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSK 274
           VEEKK K+ K  R  ++D   +K+E   + + S  +  RSR  S  +   S    K+ S 
Sbjct: 398 VEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSS 457

Query: 275 KKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDI 334
           K K   +         ++ KR RS S+       +SK     +++      ++ K +R  
Sbjct: 458 KHKNESK--------EKSNKRSRSGSQGRTDSVEKSK-----KREHSPSKEKSRKRSRSK 504

Query: 335 EISTEEEKDTGDLKDSSLLKTKRK----HKKKHKERHKMGEEVI 374
           E S   ++D  D KD S    +R+     ++  +++HK  +E +
Sbjct: 505 ERS--HKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDETV 546



 Score = 37.7 bits (86), Expect = 0.029
 Identities = 64/285 (22%), Positives = 123/285 (43%), Gaps = 45/285 (15%)

Query: 199 IFPKTVKNKPIPALRVVEE-------KKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKM 251
           +FP+     P+P  + +++       K KK  K+G  + + +++ +       + S  + 
Sbjct: 217 LFPRI----PVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRS 272

Query: 252 -KRSRPTSE-----GS-----DIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSS 300
            +RSR  S      GS     ++E  + +++  ++ K+R++    S    R  +R+RS S
Sbjct: 273 PRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRS 332

Query: 301 EDAESLAPRSKVKKIIQKDIIKEASEASKENR------DIEISTEEEKDTGDLKDSSLLK 354
            +      RS+ +K  ++D  +E  + ++  R      D E   E EK+    ++ S  +
Sbjct: 333 RERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQ 392

Query: 355 TKR--KHKKKHKE-----RHK-----MGEEVIPLRVLSKSEWMDLKKEYLALQKASMASL 402
             R    +KKHKE     RH+       +E    R  S+      +       K S +  
Sbjct: 393 RSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRS 452

Query: 403 KKTISQIKSESEMETD----SGVPQNTGMKNEKTANREECRTQEK 443
           K+  S+ K+ES+ +++    SG    T    EK+  RE   ++EK
Sbjct: 453 KEKSSKHKNESKEKSNKRSRSGSQGRTD-SVEKSKKREHSPSKEK 496


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.127    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,461,190
Number of Sequences: 37866
Number of extensions: 1021575
Number of successful extensions: 11758
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 268
Number of HSP's successfully gapped in prelim test: 797
Number of HSP's that attempted gapping in prelim test: 6456
Number of HSP's gapped (non-prelim): 4129
length of query: 582
length of database: 18,247,518
effective HSP length: 108
effective length of query: 474
effective length of database: 14,157,990
effective search space: 6710887260
effective search space used: 6710887260
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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