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Search of human proteins with 149363642
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
(1427 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149363642 coiled-coil domain containing 144A [Homo sapiens] 2840 0.0
gi|116517224 coiled-coil domain containing 144B [Homo sapiens] 1414 0.0
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 723 0.0
gi|239756753 PREDICTED: similar to coiled-coil domain containing... 452 e-126
gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens] 442 e-124
gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo... 442 e-124
gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo... 442 e-123
gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH po... 371 e-102
gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH po... 367 e-101
gi|124517695 ankyrin repeat domain 36B [Homo sapiens] 362 1e-99
gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens] 360 5e-99
gi|115495445 ankyrin repeat domain 30A [Homo sapiens] 343 7e-94
gi|169163827 PREDICTED: similar to UPF0634 protein KIAA1641 [Hom... 323 7e-88
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 281 2e-75
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 281 2e-75
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 280 9e-75
gi|51972186 coiled-coil domain containing 144 family, N-terminal... 278 2e-74
gi|222537750 ankyrin repeat domain 30B [Homo sapiens] 278 4e-74
gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member ... 276 1e-73
gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member ... 276 1e-73
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa... 272 1e-72
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 271 3e-72
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 271 3e-72
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 271 3e-72
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 271 4e-72
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 270 1e-71
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa... 265 3e-70
gi|239754871 PREDICTED: similar to Coiled-coil domain-containing... 189 2e-47
gi|239749410 PREDICTED: similar to Coiled-coil domain-containing... 189 2e-47
gi|239743545 PREDICTED: hypothetical protein XP_002342885 [Homo ... 189 2e-47
>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
Length = 1427
Score = 2840 bits (7361), Expect = 0.0
Identities = 1427/1427 (100%), Positives = 1427/1427 (100%)
Query: 1 MASWGGEKRGGAEGSPKPAVYATRKTPSVGSQGDQWYLGYPGDQWSSGFPYSWWKNSVGS 60
MASWGGEKRGGAEGSPKPAVYATRKTPSVGSQGDQWYLGYPGDQWSSGFPYSWWKNSVGS
Sbjct: 1 MASWGGEKRGGAEGSPKPAVYATRKTPSVGSQGDQWYLGYPGDQWSSGFPYSWWKNSVGS 60
Query: 61 ESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRKKSIQQLV 120
ESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRKKSIQQLV
Sbjct: 61 ESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRKKSIQQLV 120
Query: 121 PEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKE 180
PEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKE
Sbjct: 121 PEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKE 180
Query: 181 LGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDSELTSEEEQERLKGC 240
LGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDSELTSEEEQERLKGC
Sbjct: 181 LGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDSELTSEEEQERLKGC 240
Query: 241 ENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQ 300
ENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQ
Sbjct: 241 ENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQ 300
Query: 301 RFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPFNLTNNIPGCEEEDASEISVSVVFET 360
RFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPFNLTNNIPGCEEEDASEISVSVVFET
Sbjct: 301 RFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPFNLTNNIPGCEEEDASEISVSVVFET 360
Query: 361 FPEQKEPSLKNIIHPYYHPYSGSQEHVCQSSSKFHLHENKLDCDNDNKPGIGHIFSTDKN 420
FPEQKEPSLKNIIHPYYHPYSGSQEHVCQSSSKFHLHENKLDCDNDNKPGIGHIFSTDKN
Sbjct: 361 FPEQKEPSLKNIIHPYYHPYSGSQEHVCQSSSKFHLHENKLDCDNDNKPGIGHIFSTDKN 420
Query: 421 FHNDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLP 480
FHNDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLP
Sbjct: 421 FHNDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLP 480
Query: 481 PDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTE 540
PDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTE
Sbjct: 481 PDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTE 540
Query: 541 LSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEP 600
LSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEP
Sbjct: 541 LSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEP 600
Query: 601 SEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLT 660
SEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLT
Sbjct: 601 SEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLT 660
Query: 661 VKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYN 720
VKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYN
Sbjct: 661 VKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYN 720
Query: 721 KDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQD 780
KDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQD
Sbjct: 721 KDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQD 780
Query: 781 ARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKN 840
ARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKN
Sbjct: 781 ARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKN 840
Query: 841 QNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELE 900
QNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELE
Sbjct: 841 QNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELE 900
Query: 901 NGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSG 960
NGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSG
Sbjct: 901 NGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSG 960
Query: 961 LQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQM 1020
LQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQM
Sbjct: 961 LQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQM 1020
Query: 1021 YQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSA 1080
YQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSA
Sbjct: 1021 YQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSA 1080
Query: 1081 AKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLH 1140
AKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLH
Sbjct: 1081 AKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLH 1140
Query: 1141 LDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKL 1200
LDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKL
Sbjct: 1141 LDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKL 1200
Query: 1201 LIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISR 1260
LIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISR
Sbjct: 1201 LIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISR 1260
Query: 1261 IKTSQADFNKTELERYKELYLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSL 1320
IKTSQADFNKTELERYKELYLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSL
Sbjct: 1261 IKTSQADFNKTELERYKELYLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSL 1320
Query: 1321 FTAYATRPVLESPCVGNLNDSEGLNRKHIPRKKRSALKDMESYLLKMQQKLQNDLTAEVA 1380
FTAYATRPVLESPCVGNLNDSEGLNRKHIPRKKRSALKDMESYLLKMQQKLQNDLTAEVA
Sbjct: 1321 FTAYATRPVLESPCVGNLNDSEGLNRKHIPRKKRSALKDMESYLLKMQQKLQNDLTAEVA 1380
Query: 1381 GSSQTGLHRIPQCSSFSSSSLHLLLCSICQPFFLILQLLLNMNLDPI 1427
GSSQTGLHRIPQCSSFSSSSLHLLLCSICQPFFLILQLLLNMNLDPI
Sbjct: 1381 GSSQTGLHRIPQCSSFSSSSLHLLLCSICQPFFLILQLLLNMNLDPI 1427
>gi|116517224 coiled-coil domain containing 144B [Homo sapiens]
Length = 725
Score = 1414 bits (3659), Expect = 0.0
Identities = 692/712 (97%), Positives = 697/712 (97%)
Query: 1 MASWGGEKRGGAEGSPKPAVYATRKTPSVGSQGDQWYLGYPGDQWSSGFPYSWWKNSVGS 60
MASWGGEKRGGAEGSPK AVYATRKT SV SQ DQWYLGYPGDQWSSGF YSWWKNSVGS
Sbjct: 1 MASWGGEKRGGAEGSPKLAVYATRKTRSVRSQEDQWYLGYPGDQWSSGFSYSWWKNSVGS 60
Query: 61 ESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRKKSIQQLV 120
ESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEH+LAPGDTGVDKRDRKKSIQQLV
Sbjct: 61 ESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHVLAPGDTGVDKRDRKKSIQQLV 120
Query: 121 PEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKE 180
PEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKV DK PSVSPSMPENQSATKE
Sbjct: 121 PEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVGDKSPSVSPSMPENQSATKE 180
Query: 181 LGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDSELTSEEEQERLKGC 240
LGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQD ELTSEEEQERLKGC
Sbjct: 181 LGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDLELTSEEEQERLKGC 240
Query: 241 ENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQ 300
ENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQ
Sbjct: 241 ENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQ 300
Query: 301 RFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPFNLTNNIPGCEEEDASEISVSVVFET 360
RFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPFNLTNNIPGCEEEDASEISVSVVFET
Sbjct: 301 RFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPFNLTNNIPGCEEEDASEISVSVVFET 360
Query: 361 FPEQKEPSLKNIIHPYYHPYSGSQEHVCQSSSKFHLHENKLDCDNDNKPGIGHIFSTDKN 420
FPEQKEPSLKNIIHPYYHPYSGSQEHVCQSSSK HLHENKLDCDNDNK GIGHIFSTD N
Sbjct: 361 FPEQKEPSLKNIIHPYYHPYSGSQEHVCQSSSKLHLHENKLDCDNDNKLGIGHIFSTDNN 420
Query: 421 FHNDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLP 480
FHNDASTKKARNPEVV VEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLP
Sbjct: 421 FHNDASTKKARNPEVVTVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLP 480
Query: 481 PDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTE 540
PDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKE+VQLHK+VEEEMEKHRSNSTE
Sbjct: 481 PDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKENVQLHKEVEEEMEKHRSNSTE 540
Query: 541 LSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEP 600
LSGTLTDGTTVGNDDDGLNQQIPRKEN EHDRPADKT+NEKN+VKNQIYPEADFADSMEP
Sbjct: 541 LSGTLTDGTTVGNDDDGLNQQIPRKENEEHDRPADKTANEKNKVKNQIYPEADFADSMEP 600
Query: 601 SEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLT 660
SEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLT
Sbjct: 601 SEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLT 660
Query: 661 VKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEK 712
VKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQEN K
Sbjct: 661 VKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENGRK 712
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 723 bits (1866), Expect = 0.0
Identities = 532/1366 (38%), Positives = 745/1366 (54%), Gaps = 194/1366 (14%)
Query: 88 ARSGDVPGVEHILAPGDTGVDKRDRKKSIQQLVPEYKEKQTPESLPQNNNPDWHPTNLTL 147
A SG + L V+ D+ +S QL+ EYKE++ P+ QN+N + +L
Sbjct: 186 AVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDESSEDSL 245
Query: 148 S--------DETCQRS--KNLKVDDKC---PSVSPSMPENQSATKELGQMNLTEREKMDT 194
S D++ S ++L D K PS++ M +Q + K L T R
Sbjct: 246 SRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVR----- 300
Query: 195 GVVLLSGNDTLHDLCQSQLPENKESKEAEQDSELTSEEEQERLKGCENKQP---QKTSQE 251
+GN TL + ++DS+ E E L K T Q
Sbjct: 301 -----TGNRTLFE---------------DRDSDSQDEVVVESLPTTSIKVQCFSHPTYQS 340
Query: 252 PEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKI 311
P++ + + P + K E + G + +N + + I
Sbjct: 341 PDLLPKPSHKSL----ANPGLMKEEPT--KPGIAKKENGIDI-----------------I 377
Query: 312 PACPEEEPLLDNSTRGTDV-KDIPFNLTNNIP-GCEEEDASEISVSVVFETFPEQKEPSL 369
+ P E+ DN T +V K+ ++ + + G EE+ S + E FP++
Sbjct: 378 ESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPWDSESISENFPQK----- 432
Query: 370 KNIIHPYYHPYSGSQEHV-------------CQSSSKFHLHENKLDCDNDNKPGIGHIFS 416
+ P G ++++ C S S+ D N P + H+ S
Sbjct: 433 --YVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMP-VAHMES 489
Query: 417 TDKNFH-------NDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSL 469
++ H D+ KA + V + + E DL++ Q + GS NN
Sbjct: 490 PERYLHLKPTIEMKDSVPNKAGGMKDV--QTSKAAEHDLEVASEEEQERE-GSENN---- 542
Query: 470 KPKLENLSSLPPDSDRTSEVYLHEELQQD----------MQKFKN------EVNTLEEEF 513
+P++E +++ +H+ D +QK K+ + E +
Sbjct: 543 QPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKE 602
Query: 514 LALKKEDVQLHKDVEEEMEKHRSNSTELS-----GTLTDGTTVGNDDDGLNQQIPRKENG 568
A +Q+ + E EK S + S +L G + DDD +I E
Sbjct: 603 YASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEG- 661
Query: 569 EHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRME 628
RP KTSNEKN+VKNQI D D + SE ASEDCEL HS Y+NFMLLIEQL ME
Sbjct: 662 ---RPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGME 718
Query: 629 YKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLE 688
KDS SL +IQD CE LL+LK NHC+ LTVK+K+ME+ V+VLQ ELSETK+ K QLE
Sbjct: 719 CKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLE 778
Query: 689 LQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLR 748
QK+EWE+EL LR +L QE E++RNAD LY K EQLR KEE+ K VE KQQL+ +L+
Sbjct: 779 HQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQ 838
Query: 749 RLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILT---SKQKELEMARKKMNS 805
L ELRTV++NL+ VVQERNDAQ+QLS EQ+AR+LQD ILT SKQKE+EMA+KKMNS
Sbjct: 839 TLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNS 898
Query: 806 EISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQK 865
E SH H++EKDL H++ MLQEEIA+LRLEIDTIKNQN++KEKK FED++ VKEKN++LQK
Sbjct: 899 ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQK 958
Query: 866 IIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVR 925
IK NEETLT+TI QY+G+L+ LTAEN +LNS+LEN KQ++ERLE E+ESY RLAAA+
Sbjct: 959 TIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIH 1018
Query: 926 DCDQSQTA-RDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQI 984
D DQS+T+ R+L+L FQR R E RL DKM D+S L+ NEILS++L ESK+NSL+I
Sbjct: 1019 DRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI 1078
Query: 985 QLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQ 1044
+ H+TRDAL ++L LERVQ+DLSQTQCQ KE EQ YQ EQ K+ KYI KQESVEERLSQ
Sbjct: 1079 EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQ 1138
Query: 1045 LQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMD 1104
LQSENMLLRQQLDDAH KA+++EKT IQDQFH+ + LQAESEKQ L L+E+NKEL+
Sbjct: 1139 LQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELIS 1198
Query: 1105 EYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKAIQKQC 1164
E NHLKER Q E EKA R++ + + Q+ +L TL +
Sbjct: 1199 ECNHLKERQYQYENEKAEREVVVRQLQQ----------------ELADTLKKQSMSEASL 1242
Query: 1165 ETLQKNKKQLKQEVVNLKSYME--RNMLERGKAEWHKLLIEERARKEIEEKLNEAILTLQ 1222
E + + L+ E +LK + RN L+ E +++ EA+ +
Sbjct: 1243 EVTSRYRINLEDETQDLKKKLGQIRNQLQ-----------------EAQDRHTEAVRCAE 1285
Query: 1223 KQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKELYLE 1282
K H+Q +L +DN ++++T+K +I ++ + + N +E E KE +
Sbjct: 1286 KMQ--DHKQ--KLEKDN-----AKLKVTVKKQMDKIEELQKNLLNANLSEDE--KEQLKK 1334
Query: 1283 EVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSLFTAYATRPVLESPCVGNLNDSE 1342
+++++SL L + E+ + +E+E T ++L TR L G +
Sbjct: 1335 LMELKQSLECNLDQ------EMKKNVELEREITGFKNLLK--MTRKKLNEYENGEFSFHG 1386
Query: 1343 GLNRKHIPRKKRSALKDMESYLLKMQQKLQNDLTAEVAGSSQTGLH 1388
L +++ +M+ + K++ K+ +DLTAE+ + LH
Sbjct: 1387 DL---------KTSQFEMDIQINKLKHKI-DDLTAELETAGSKCLH 1422
Score = 355 bits (910), Expect = 2e-97
Identities = 303/948 (31%), Positives = 469/948 (49%), Gaps = 133/948 (14%)
Query: 491 LHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNST---ELSGTLTD 547
L L Q+ +K +N E+ L++++ Q K+VE + + S T EL ++
Sbjct: 791 LRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSN 850
Query: 548 GTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASED 607
V + + +Q+ R++N + T++ + + ++ A + E S E+
Sbjct: 851 LNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEM---AQKKMNSENSHSHEEE 907
Query: 608 CELSHSVYENFMLL--IEQLRMEYKDSASLPRIQDTFCL---------CEHLLKLKNNHC 656
+LSH +N ML I LR+E + + ++ C E L K +
Sbjct: 908 KDLSH---KNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNE 964
Query: 657 DQLTVKLKQMENMVSVL--QNELSETKKTKLQLELQKIEWEKELYDLRLALK-----QEN 709
+ LT + Q +SVL +N + +K + +++E E E Y RLA Q
Sbjct: 965 ETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE 1024
Query: 710 EEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERN 769
KR ++ + + ++ +++ V + L + + + + N+L++
Sbjct: 1025 TSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTR 1084
Query: 770 DA--QKQLSEEQDARILQDQILTSKQ-KELEMARKKMNSEISHRHQKEKDLFHEDCMLQE 826
DA +K L E R+ +D T Q KE+E + +++ K++ + LQ
Sbjct: 1085 DALREKTLGLE---RVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQS 1141
Query: 827 EIALLRLEIDTIKNQNKQKEKKYF----------EDIEAVKEKNDNLQKIIKLNEETLTE 876
E LLR ++D N+ KEK + ++A EK L + + N+E ++E
Sbjct: 1142 ENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLE--ERNKELISE 1199
Query: 877 T--ILQYSGQLNNLTAENKILNSELENG------KQNQERLEIEMES-YRCRLAAAVRDC 927
+ + Q N AE +++ +L+ KQ+ +E+ S YR L +D
Sbjct: 1200 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDL 1259
Query: 928 DQSQ-TARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQL 986
+ R+ + Q E VR +KM+ L+ N L + KI LQ L
Sbjct: 1260 KKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNL 1319
Query: 987 HNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQ 1046
N + + E+ +LKK + ++S+E L Q
Sbjct: 1320 LNAN-----------------------------LSEDEKEQLKKLMELKQSLECNLDQEM 1350
Query: 1047 SENMLLRQQLDD-------AHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKN 1099
+N+ L +++ KK N E + FH K Q E + QI
Sbjct: 1351 KKNVELEREITGFKNLLKMTRKKLNEYENGEFS----FHGDLKTSQFEMDIQI------- 1399
Query: 1100 KELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKA 1159
N LK ++D DLT ET S+CLHLD +N++LQ + L SMK
Sbjct: 1400 -------NKLKHKID-----------DLTAELETAGSKCLHLDTKNQILQ--EELLSMKT 1439
Query: 1160 IQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAIL 1219
+QK+CE LQKNKK+L+QEV+NL+S++ERNM+E G+ + +K IEERAR+EI EKL E L
Sbjct: 1440 VQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNL 1499
Query: 1220 TLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKEL 1279
LQ QAA S E L Q RE+N S+K+QMEL IKDLESE+S+IKTSQ DFNKTELE+YK+L
Sbjct: 1500 FLQAQAA-SQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQL 1558
Query: 1280 YLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSLFTAYATRPVLESPCVGNLN 1339
YLEE+KVR+SLS++L++TNE +AEV+T+L VEK+Q SRSLFT TRPV+E PCVGNLN
Sbjct: 1559 YLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQ--SRSLFTTLTTRPVMEPPCVGNLN 1616
Query: 1340 DSEGLNRKHIPRKK--------RSALKDMESYLLKMQQKLQNDLTAEV 1379
+S LNRK IPR+ R++ ME+YL KMQQ+L+ ++T E+
Sbjct: 1617 NSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITREL 1664
Score = 87.4 bits (215), Expect = 9e-17
Identities = 163/857 (19%), Positives = 348/857 (40%), Gaps = 124/857 (14%)
Query: 419 KNFHNDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSS 478
+N H+ K + ++ E ++ KN NQ + + K +K K E+L
Sbjct: 899 ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQK 958
Query: 479 LPPDSDRTSEVYLHEELQQDMQKFKNEVN--TLEEEFLALKKEDVQLHKD-VEEEMEKHR 535
++ T L Q + ++ ++ T E L K E+ + K+ +E E+E +
Sbjct: 959 TIKQNEET--------LTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYH 1010
Query: 536 SNSTELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFA 595
S R HDR +TS + E+ Q +
Sbjct: 1011 S---------------------------RLAAAIHDRDQSETSKRELELAFQRARD---- 1039
Query: 596 DSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNH 655
E S + + ++ +N +L +QL +K + L ++ F L+ K
Sbjct: 1040 ---ECSRLQDKMNFDVSNLKDNNEILSQQL---FKTESKLNSLEIEFHHTRDALREK--- 1090
Query: 656 CDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNA 715
T+ L++++ +S Q ++ E ++ K Q E K+ + KQE+ E+R +
Sbjct: 1091 ----TLGLERVQKDLSQTQCQMKEMEQ-KYQNEQVKVN--------KYIGKQESVEERLS 1137
Query: 716 DMLYNKDSEQLRIKEEECGKVVETKQQLKWNLR----RLVKELRTVRNNLDLVVQERNDA 771
+ ++ LR + ++ + K++ N++ +V++L+ L+++ERN
Sbjct: 1138 QL--QSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERN-- 1193
Query: 772 QKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE-------KDLFHEDCML 824
K+L E + + +++ E E+ +++ E++ +K+ + L
Sbjct: 1194 -KELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINL 1252
Query: 825 QEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQ 884
++E L+ ++ I+NQ ++ + ++ E + ++ D+ QK+ K N + L T+ + +
Sbjct: 1253 EDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAK-LKVTVKKQMDK 1311
Query: 885 LNNLTAENKILNSELENGKQNQERLEIEM-ESYRCRLAAAV-RDCDQSQTARDLKLDFQR 942
+ L + +LN+ L ++ Q + +E+ +S C L + ++ + + K +
Sbjct: 1312 IEEL--QKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKM 1369
Query: 943 TRQEWVRLHD--------------KMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHN 988
TR++ + +M + ++ L+ K + L+ +L A SK + L
Sbjct: 1370 TRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKC----LHLDT 1425
Query: 989 TRDALGRESLILERVQRDLSQTQCQKKETEQ------------MYQIEQSKLKKYIAKQE 1036
L E L ++ VQ+ + Q KK+ EQ M ++ Q K K ++
Sbjct: 1426 KNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEER 1485
Query: 1037 SVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQ 1096
+ +E +L+ N+ L+ Q +E ++++ Q K+L++E K S +
Sbjct: 1486 ARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQE 1545
Query: 1097 EKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFS 1156
+ NK +++Y L + K + + E V ++ L + + L TL +
Sbjct: 1546 DFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKL--LVEKQQSRSLFTTLTT 1603
Query: 1157 MKAIQKQC-----ETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIE 1211
++ C +L N+K + +E NL E + +++ K I
Sbjct: 1604 RPVMEPPCVGNLNNSLDLNRKLIPRE--NLVISTSNPRASNNSMENYLSKMQQELEKNIT 1661
Query: 1212 EKLNEAILTLQKQAAVS 1228
+L EA L+ + S
Sbjct: 1662 RELKEAAAELESGSIAS 1678
Score = 50.1 bits (118), Expect = 2e-05
Identities = 24/58 (41%), Positives = 37/58 (63%)
Query: 55 KNSVGSESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDR 112
++S G + GEGA QP + VR DLG++H+AA +G+V V+ IL G++ RD+
Sbjct: 21 RSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDK 78
>gi|239756753 PREDICTED: similar to coiled-coil domain containing
144A [Homo sapiens]
Length = 226
Score = 452 bits (1162), Expect = e-126
Identities = 214/226 (94%), Positives = 218/226 (96%)
Query: 1 MASWGGEKRGGAEGSPKPAVYATRKTPSVGSQGDQWYLGYPGDQWSSGFPYSWWKNSVGS 60
M SWGGEKRGGAEGSPKPAVYATRKT SV SQ DQWYLGYPGDQWSSGF YSWWKNSVGS
Sbjct: 1 MVSWGGEKRGGAEGSPKPAVYATRKTGSVRSQEDQWYLGYPGDQWSSGFSYSWWKNSVGS 60
Query: 61 ESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRKKSIQQLV 120
ESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEH+L PGDTGVDKRDRKKSIQQLV
Sbjct: 61 ESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHVLVPGDTGVDKRDRKKSIQQLV 120
Query: 121 PEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKE 180
PEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKE
Sbjct: 121 PEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKE 180
Query: 181 LGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDS 226
LGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKE +++
Sbjct: 181 LGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEGNKEA 226
>gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]
Length = 917
Score = 442 bits (1138), Expect = e-124
Identities = 281/669 (42%), Positives = 397/669 (59%), Gaps = 77/669 (11%)
Query: 527 VEEEMEKHRSNSTELSGTL--TDGTTVGNDDDGL----------NQQIPRKENGEHDRPA 574
VEE+M+K R+ E+S + D +D D L N Q P KENGE DR A
Sbjct: 298 VEEKMKKCRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLA 357
Query: 575 DKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSAS 634
KTSNEK++VK+QIY D D SE SED EL +S ENFMLLI+Q ME KD S
Sbjct: 358 RKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFMLLIKQSGMECKDFVS 417
Query: 635 LPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEW 694
L + ++ C ++ + +C++L VK ++M+N +SVLQ LSET KTK Q E Q ++
Sbjct: 418 LSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQG 477
Query: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754
+K+L +LR L+Q+ EE+ A+ LY KD E+L+I EE+ E K+Q K L+ L EL
Sbjct: 478 KKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVEL 537
Query: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814
+TVR+N +++ H H++E
Sbjct: 538 KTVRSN-------------------------------------------SNQNFHTHERE 554
Query: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETL 874
+DL+ E+ ++++EIA LRLEIDTIK+QN++ E KYF+DIE +KE N++L+K +K NEETL
Sbjct: 555 RDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEETL 614
Query: 875 TETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTA- 933
T+TI +YS +LN L EN +LNSEL+ KQ+ RLE EMESYRCRLAAA+ D DQ Q++
Sbjct: 615 TKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSK 674
Query: 934 RDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDAL 993
RDL+L FQ T EW L + + +ILS++LS AES + L+ +LH R+AL
Sbjct: 675 RDLQLAFQSTVNEWCHLQEDTNSHI-------QILSQQLSKAESTSSGLETELHYEREAL 727
Query: 994 GRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLR 1053
++L +E +Q LS+TQ + ++ E MYQ +Q L+KY+ KQ+SVE+ L QLQS+N+L +
Sbjct: 728 KEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQ 787
Query: 1054 QQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERM 1113
QQ +DA KKA++QEKT IQ + + LQAE K L+E NK LM E LKER
Sbjct: 788 QQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRK----LEENNKGLMKECTLLKERQ 843
Query: 1114 DQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKA----IQKQCETLQK 1169
Q EKEK R++ + Q V DA N+ L L+ L ++ + ++L+K
Sbjct: 844 CQYEKEKEEREVVRRQLQREVD------DALNKQLLLEAMLEISSERRINLEDEAQSLKK 897
Query: 1170 NKKQLKQEV 1178
Q++ +V
Sbjct: 898 KLGQMRSQV 906
Score = 70.9 bits (172), Expect = 8e-12
Identities = 139/673 (20%), Positives = 277/673 (41%), Gaps = 105/673 (15%)
Query: 623 EQLRMEYKDSASLPRIQDTFCLCEH--LLKLKNNHCDQLTVKLKQMENMVSVLQNELSET 680
EQ R+E +S S P++++ C + + +N H D ++ ++ ++N +
Sbjct: 284 EQERLEGCES-SQPQVEEKMKKCRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDN 342
Query: 681 KKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLY-NKDSEQLRIKEEECGKVVET 739
++ + E +D RLA K NE+ + +Y D + E+ + E
Sbjct: 343 HQSPGK--------ENGEFD-RLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDEL 393
Query: 740 KQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMA 799
N L+K+ + + + +N + R ++DQ ++ +++
Sbjct: 394 PYSDDENFMLLIKQSGMECKDFVSLSKSKN------ATAACGRSIEDQKCYCERLKVKFQ 447
Query: 800 RKKMNSEISHRHQKEKDLF-----HEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIE 854
+ K N + + E D H++ ++++ LR + + + + E+ Y +DIE
Sbjct: 448 KMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKDIE 507
Query: 855 AVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEME 914
+K I++ T TE Q L +L E K + S N QN E E +
Sbjct: 508 ELK--------IMEEQYRTQTEVKKQSKLTLKSLEVELKTVRS---NSNQNFHTHERERD 556
Query: 915 SYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSN 974
++ +RD + AR L+L+ + + +K D+ ++ NE L + L
Sbjct: 557 LWQEN--HLMRD----EIAR-LRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKR 609
Query: 975 AES-----------KINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMY-Q 1022
E ++N L + L +E + R++ ++ +C+ + Q
Sbjct: 610 NEETLTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQ 669
Query: 1023 IEQSKLKKYIAKQESVEERLSQLQSEN---MLLRQQLDDAHKKANSQEKTSSTIQDQFHS 1079
+ SK +A Q +V E + N +L QQL A E TSS ++ + H
Sbjct: 670 RQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKA-------ESTSSGLETELHY 722
Query: 1080 AA-----KNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV 1134
K L E + +LS ++ +++ H+ + DQ EK RK Q++V
Sbjct: 723 EREALKEKTLHIEHMQGVLSRTQRR---LEDIEHMYQN-DQPILEKYVRK------QQSV 772
Query: 1135 PSRCLHLDAENEVLQLQ------------QTLFSMKA--------IQKQCETLQKNKKQL 1174
L ++N + Q Q +T+ +++ +Q +C L++N K L
Sbjct: 773 EDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGL 832
Query: 1175 KQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQ 1234
+E LK + E+ K E + ++ + ++E+++ LN+ +L L+ +S E+ +
Sbjct: 833 MKECTLLKE--RQCQYEKEKEE--REVVRRQLQREVDDALNKQLL-LEAMLEISSERRIN 887
Query: 1235 LREDNTTSIKTQM 1247
L ED S+K ++
Sbjct: 888 L-EDEAQSLKKKL 899
Score = 62.0 bits (149), Expect = 4e-09
Identities = 145/717 (20%), Positives = 282/717 (39%), Gaps = 121/717 (16%)
Query: 218 ESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEE 277
++ +EQD E+TSE EQERL+GCE+ QP Q E K C + + + + H S+
Sbjct: 269 QNSNSEQDLEMTSEGEQERLEGCESSQP----QVEEKMKKCRNKKMEVSRNV-HADDSD- 322
Query: 278 MWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPF-- 335
+ + + +I+++K R + ++ + S + VK +
Sbjct: 323 --------NYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFT 374
Query: 336 NLTNNIPG----CEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQSS 391
+ N+I G E+D S F +Q K+ + S S+ ++
Sbjct: 375 DDLNDISGSSEKTSEDDELPYSDDENFMLLIKQSGMECKDFV-------SLSKSKNATAA 427
Query: 392 SKFHLHENKLDCD---------NDNKPGIGHIFS-TDK-----NFHNDASTKKARNPEVV 436
+ + K C+ +N + + S TDK N KK N +
Sbjct: 428 CGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFI 487
Query: 437 MVEMKEDQ-------EFDLQMTKNMNQ------NSDSGSTNNYKSLKPKLENLSSLPPDS 483
+ + +E++ E D++ K M + S KSL+ +L+ + S +
Sbjct: 488 LQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQN 547
Query: 484 DRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSG 543
T E +L Q+ ++E+ L E +K ++ + +++E + N+ +L
Sbjct: 548 FHTHE--RERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEK 605
Query: 544 TLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEI 603
TL +++ L + I R + + + +E + +++ E +E +E+
Sbjct: 606 TLK------RNEETLTKTITR-----YSKELNVLMDENTMLNSELQKEKQSMSRLE-TEM 653
Query: 604 ASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKL 663
S C L+ ++ ++ R K L Q T HL + N+H L+ +L
Sbjct: 654 ESYRCRLAAALCDH------DQRQSSKRDLQL-AFQSTVNEWCHLQEDTNSHIQILSQQL 706
Query: 664 KQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDS 723
+ E+ S L+ EL ++ + L + ++ L + + + +Y D
Sbjct: 707 SKAESTSSGLETELHYEREALKEKTL-------HIEHMQGVLSRTQRRLEDIEHMYQNDQ 759
Query: 724 EQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARI 783
L K V +Q ++ L +L + NL L Q+ NDA+K+
Sbjct: 760 PILE-------KYVRKQQSVEDGLFQLQSQ------NL-LYQQQCNDARKKADN------ 799
Query: 784 LQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNK 843
Q++ + + Q + E +K+ +E + K L E +L+E K
Sbjct: 800 -QEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQC----------QYEK 848
Query: 844 QKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLN-NLTAENKILNSEL 899
+KE++ + +E +D LN++ L E +L+ S + NL E + L +L
Sbjct: 849 EKEEREVVRRQLQREVDD------ALNKQLLLEAMLEISSERRINLEDEAQSLKKKL 899
Score = 35.0 bits (79), Expect = 0.52
Identities = 106/581 (18%), Positives = 237/581 (40%), Gaps = 108/581 (18%)
Query: 742 QLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARK 801
+ K N RR K L+ + DL + + ++ E +++++ + K++E++R
Sbjct: 258 EYKANKRR--KSLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRN 315
Query: 802 KMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKND 861
H + D +++D + L +I K N Q K + + + K
Sbjct: 316 V--------HADDSDNYNDD------VDELIHKIKNRKPDNHQSPGKENGEFDRLARKTS 361
Query: 862 NLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLA 921
N + +K ++ T+ + SG + ++++ S+ EN L I+ C+
Sbjct: 362 NEKSKVK-SQIYFTDDLNDISGSSEKTSEDDELPYSDDENFM-----LLIKQSGMECKDF 415
Query: 922 AAVRDCDQSQTARDLKLDFQRTRQEWVRLH-DKMKVDMSGLQAKNEILSEK-LSNAESKI 979
++ + A ++ Q+ E +++ KMK ++S LQ ++LSE + ++S+
Sbjct: 416 VSLSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQ---KVLSETDKTKSQSEH 472
Query: 980 NSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVE 1039
+LQ G++ L ++ L Q + ++ + E++Y+ + +LK I +++
Sbjct: 473 QNLQ----------GKKKLC--NLRFILQQQEEERIKAEELYEKDIEELK--IMEEQYRT 518
Query: 1040 ERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKN 1099
+ + QS+ L +++ ++NS + FH+ E E+ L ++N
Sbjct: 519 QTEVKKQSKLTLKSLEVELKTVRSNSNQN--------FHTH------ERERD---LWQEN 561
Query: 1100 KELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKA 1159
+ DE L+ +D + + QET EN+ + ++
Sbjct: 562 HLMRDEIARLRLEIDTIKHQN----------QET----------ENKYFK------DIEI 595
Query: 1160 IQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAIL 1219
I++ E L+K K+ ++ + + + + +L++E E
Sbjct: 596 IKENNEDLEKTLKRNEETLTKTITRYSKEL---------NVLMDENTMLNSE-------- 638
Query: 1220 TLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKEL 1279
LQK+ +Q + E S + ++ + D + S + Q F T + + L
Sbjct: 639 -LQKE-----KQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQST-VNEWCHL 691
Query: 1280 YLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSL 1320
+ + LS +LS+ + + T+L E+E + ++L
Sbjct: 692 QEDTNSHIQILSQQLSKAESTSSGLETELHYEREALKEKTL 732
Score = 30.8 bits (68), Expect = 9.7
Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 7/62 (11%)
Query: 52 SWWKNSVGSESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRD 111
+W KN + P + VR +DLG +H+AA +GDV V + ++ RD
Sbjct: 17 TWRKN-------RDKDGFSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRD 69
Query: 112 RK 113
+K
Sbjct: 70 KK 71
>gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo
sapiens]
Length = 917
Score = 442 bits (1138), Expect = e-124
Identities = 281/669 (42%), Positives = 397/669 (59%), Gaps = 77/669 (11%)
Query: 527 VEEEMEKHRSNSTELSGTL--TDGTTVGNDDDGL----------NQQIPRKENGEHDRPA 574
VEE+M+K R+ E+S + D +D D L N Q P KENGE DR A
Sbjct: 298 VEEKMKKCRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLA 357
Query: 575 DKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSAS 634
KTSNEK++VK+QIY D D SE SED EL +S ENFMLLI+Q ME KD S
Sbjct: 358 RKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFMLLIKQSGMECKDFVS 417
Query: 635 LPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEW 694
L + ++ C ++ + +C++L VK ++M+N +SVLQ LSET KTK Q E Q ++
Sbjct: 418 LSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQG 477
Query: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754
+K+L +LR L+Q+ EE+ A+ LY KD E+L+I EE+ E K+Q K L+ L EL
Sbjct: 478 KKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVEL 537
Query: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814
+TVR+N +++ H H++E
Sbjct: 538 KTVRSN-------------------------------------------SNQNFHTHERE 554
Query: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETL 874
+DL+ E+ ++++EIA LRLEIDTIK+QN++ E KYF+DIE +KE N++L+K +K NEETL
Sbjct: 555 RDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEETL 614
Query: 875 TETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTA- 933
T+TI +YS +LN L EN +LNSEL+ KQ+ RLE EMESYRCRLAAA+ D DQ Q++
Sbjct: 615 TKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSK 674
Query: 934 RDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDAL 993
RDL+L FQ T EW L + + +ILS++LS AES + L+ +LH R+AL
Sbjct: 675 RDLQLAFQSTVNEWCHLQEDTNSHI-------QILSQQLSKAESTSSGLETELHYEREAL 727
Query: 994 GRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLR 1053
++L +E +Q LS+TQ + ++ E MYQ +Q L+KY+ KQ+SVE+ L QLQS+N+L +
Sbjct: 728 KEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQ 787
Query: 1054 QQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERM 1113
QQ +DA KKA++QEKT IQ + + LQAE K L+E NK LM E LKER
Sbjct: 788 QQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRK----LEENNKGLMKECTLLKERQ 843
Query: 1114 DQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKA----IQKQCETLQK 1169
Q EKEK R++ + Q V DA N+ L L+ L ++ + ++L+K
Sbjct: 844 CQYEKEKEEREVVRRQLQREVD------DALNKQLLLEAMLEISSERRINLEDEAQSLKK 897
Query: 1170 NKKQLKQEV 1178
Q++ +V
Sbjct: 898 KLGQMRSQV 906
Score = 70.9 bits (172), Expect = 8e-12
Identities = 139/673 (20%), Positives = 277/673 (41%), Gaps = 105/673 (15%)
Query: 623 EQLRMEYKDSASLPRIQDTFCLCEH--LLKLKNNHCDQLTVKLKQMENMVSVLQNELSET 680
EQ R+E +S S P++++ C + + +N H D ++ ++ ++N +
Sbjct: 284 EQERLEGCES-SQPQVEEKMKKCRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDN 342
Query: 681 KKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLY-NKDSEQLRIKEEECGKVVET 739
++ + E +D RLA K NE+ + +Y D + E+ + E
Sbjct: 343 HQSPGK--------ENGEFD-RLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDEL 393
Query: 740 KQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMA 799
N L+K+ + + + +N + R ++DQ ++ +++
Sbjct: 394 PYSDDENFMLLIKQSGMECKDFVSLSKSKN------ATAACGRSIEDQKCYCERLKVKFQ 447
Query: 800 RKKMNSEISHRHQKEKDLF-----HEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIE 854
+ K N + + E D H++ ++++ LR + + + + E+ Y +DIE
Sbjct: 448 KMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKDIE 507
Query: 855 AVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEME 914
+K I++ T TE Q L +L E K + S N QN E E +
Sbjct: 508 ELK--------IMEEQYRTQTEVKKQSKLTLKSLEVELKTVRS---NSNQNFHTHERERD 556
Query: 915 SYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSN 974
++ +RD + AR L+L+ + + +K D+ ++ NE L + L
Sbjct: 557 LWQEN--HLMRD----EIAR-LRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKR 609
Query: 975 AES-----------KINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMY-Q 1022
E ++N L + L +E + R++ ++ +C+ + Q
Sbjct: 610 NEETLTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQ 669
Query: 1023 IEQSKLKKYIAKQESVEERLSQLQSEN---MLLRQQLDDAHKKANSQEKTSSTIQDQFHS 1079
+ SK +A Q +V E + N +L QQL A E TSS ++ + H
Sbjct: 670 RQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKA-------ESTSSGLETELHY 722
Query: 1080 AA-----KNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV 1134
K L E + +LS ++ +++ H+ + DQ EK RK Q++V
Sbjct: 723 EREALKEKTLHIEHMQGVLSRTQRR---LEDIEHMYQN-DQPILEKYVRK------QQSV 772
Query: 1135 PSRCLHLDAENEVLQLQ------------QTLFSMKA--------IQKQCETLQKNKKQL 1174
L ++N + Q Q +T+ +++ +Q +C L++N K L
Sbjct: 773 EDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGL 832
Query: 1175 KQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQ 1234
+E LK + E+ K E + ++ + ++E+++ LN+ +L L+ +S E+ +
Sbjct: 833 MKECTLLKE--RQCQYEKEKEE--REVVRRQLQREVDDALNKQLL-LEAMLEISSERRIN 887
Query: 1235 LREDNTTSIKTQM 1247
L ED S+K ++
Sbjct: 888 L-EDEAQSLKKKL 899
Score = 62.0 bits (149), Expect = 4e-09
Identities = 145/717 (20%), Positives = 282/717 (39%), Gaps = 121/717 (16%)
Query: 218 ESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEE 277
++ +EQD E+TSE EQERL+GCE+ QP Q E K C + + + + H S+
Sbjct: 269 QNSNSEQDLEMTSEGEQERLEGCESSQP----QVEEKMKKCRNKKMEVSRNV-HADDSD- 322
Query: 278 MWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPF-- 335
+ + + +I+++K R + ++ + S + VK +
Sbjct: 323 --------NYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFT 374
Query: 336 NLTNNIPG----CEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQSS 391
+ N+I G E+D S F +Q K+ + S S+ ++
Sbjct: 375 DDLNDISGSSEKTSEDDELPYSDDENFMLLIKQSGMECKDFV-------SLSKSKNATAA 427
Query: 392 SKFHLHENKLDCD---------NDNKPGIGHIFS-TDK-----NFHNDASTKKARNPEVV 436
+ + K C+ +N + + S TDK N KK N +
Sbjct: 428 CGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFI 487
Query: 437 MVEMKEDQ-------EFDLQMTKNMNQ------NSDSGSTNNYKSLKPKLENLSSLPPDS 483
+ + +E++ E D++ K M + S KSL+ +L+ + S +
Sbjct: 488 LQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQN 547
Query: 484 DRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSG 543
T E +L Q+ ++E+ L E +K ++ + +++E + N+ +L
Sbjct: 548 FHTHE--RERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEK 605
Query: 544 TLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEI 603
TL +++ L + I R + + + +E + +++ E +E +E+
Sbjct: 606 TLK------RNEETLTKTITR-----YSKELNVLMDENTMLNSELQKEKQSMSRLE-TEM 653
Query: 604 ASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKL 663
S C L+ ++ ++ R K L Q T HL + N+H L+ +L
Sbjct: 654 ESYRCRLAAALCDH------DQRQSSKRDLQL-AFQSTVNEWCHLQEDTNSHIQILSQQL 706
Query: 664 KQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDS 723
+ E+ S L+ EL ++ + L + ++ L + + + +Y D
Sbjct: 707 SKAESTSSGLETELHYEREALKEKTL-------HIEHMQGVLSRTQRRLEDIEHMYQNDQ 759
Query: 724 EQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARI 783
L K V +Q ++ L +L + NL L Q+ NDA+K+
Sbjct: 760 PILE-------KYVRKQQSVEDGLFQLQSQ------NL-LYQQQCNDARKKADN------ 799
Query: 784 LQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNK 843
Q++ + + Q + E +K+ +E + K L E +L+E K
Sbjct: 800 -QEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQC----------QYEK 848
Query: 844 QKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLN-NLTAENKILNSEL 899
+KE++ + +E +D LN++ L E +L+ S + NL E + L +L
Sbjct: 849 EKEEREVVRRQLQREVDD------ALNKQLLLEAMLEISSERRINLEDEAQSLKKKL 899
Score = 35.0 bits (79), Expect = 0.52
Identities = 106/581 (18%), Positives = 237/581 (40%), Gaps = 108/581 (18%)
Query: 742 QLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARK 801
+ K N RR K L+ + DL + + ++ E +++++ + K++E++R
Sbjct: 258 EYKANKRR--KSLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRN 315
Query: 802 KMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKND 861
H + D +++D + L +I K N Q K + + + K
Sbjct: 316 V--------HADDSDNYNDD------VDELIHKIKNRKPDNHQSPGKENGEFDRLARKTS 361
Query: 862 NLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLA 921
N + +K ++ T+ + SG + ++++ S+ EN L I+ C+
Sbjct: 362 NEKSKVK-SQIYFTDDLNDISGSSEKTSEDDELPYSDDENFM-----LLIKQSGMECKDF 415
Query: 922 AAVRDCDQSQTARDLKLDFQRTRQEWVRLH-DKMKVDMSGLQAKNEILSEK-LSNAESKI 979
++ + A ++ Q+ E +++ KMK ++S LQ ++LSE + ++S+
Sbjct: 416 VSLSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQ---KVLSETDKTKSQSEH 472
Query: 980 NSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVE 1039
+LQ G++ L ++ L Q + ++ + E++Y+ + +LK I +++
Sbjct: 473 QNLQ----------GKKKLC--NLRFILQQQEEERIKAEELYEKDIEELK--IMEEQYRT 518
Query: 1040 ERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKN 1099
+ + QS+ L +++ ++NS + FH+ E E+ L ++N
Sbjct: 519 QTEVKKQSKLTLKSLEVELKTVRSNSNQN--------FHTH------ERERD---LWQEN 561
Query: 1100 KELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKA 1159
+ DE L+ +D + + QET EN+ + ++
Sbjct: 562 HLMRDEIARLRLEIDTIKHQN----------QET----------ENKYFK------DIEI 595
Query: 1160 IQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAIL 1219
I++ E L+K K+ ++ + + + + +L++E E
Sbjct: 596 IKENNEDLEKTLKRNEETLTKTITRYSKEL---------NVLMDENTMLNSE-------- 638
Query: 1220 TLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKEL 1279
LQK+ +Q + E S + ++ + D + S + Q F T + + L
Sbjct: 639 -LQKE-----KQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQST-VNEWCHL 691
Query: 1280 YLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSL 1320
+ + LS +LS+ + + T+L E+E + ++L
Sbjct: 692 QEDTNSHIQILSQQLSKAESTSSGLETELHYEREALKEKTL 732
Score = 30.8 bits (68), Expect = 9.7
Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 7/62 (11%)
Query: 52 SWWKNSVGSESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRD 111
+W KN + P + VR +DLG +H+AA +GDV V + ++ RD
Sbjct: 17 TWRKN-------RDKDGFSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRD 69
Query: 112 RK 113
+K
Sbjct: 70 KK 71
>gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo
sapiens]
Length = 917
Score = 442 bits (1137), Expect = e-123
Identities = 281/669 (42%), Positives = 396/669 (59%), Gaps = 77/669 (11%)
Query: 527 VEEEMEKHRSNSTELSGTL--TDGTTVGNDDDGL----------NQQIPRKENGEHDRPA 574
VEE+M+K R+ E+S + D +D D L N Q P KENGE DR A
Sbjct: 298 VEEKMKKCRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLA 357
Query: 575 DKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSAS 634
KTSNEK++VK+QIY D D SE SED EL +S ENFMLLIEQ ME KD S
Sbjct: 358 RKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFMLLIEQSGMECKDFVS 417
Query: 635 LPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEW 694
L + ++ C ++ + +C++L VK ++M+N +SVLQ LSET KTK Q E Q ++
Sbjct: 418 LSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQG 477
Query: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754
+K+L +LR L+Q+ EE+ A+ LY KD E+L+I EE+ E K+Q K L+ L EL
Sbjct: 478 KKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVEL 537
Query: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814
+TVR+N +++ H H++E
Sbjct: 538 KTVRSN-------------------------------------------SNQNFHTHERE 554
Query: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETL 874
+DL+ E+ ++++EIA LRLEIDTIK+QN++ E KYF+DIE +KE N++L+K +K NEE L
Sbjct: 555 RDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEEAL 614
Query: 875 TETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTA- 933
T+TI +YS +LN L EN +LNSEL+ KQ+ RLE EMESYRCRLAAA+ D DQ Q++
Sbjct: 615 TKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSK 674
Query: 934 RDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDAL 993
RDL+L FQ T EW L + + +ILS++LS AES + L+ +LH R+AL
Sbjct: 675 RDLQLAFQSTVNEWCHLQEDTNSHI-------QILSQQLSKAESTSSGLETELHYEREAL 727
Query: 994 GRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLR 1053
++L +E +Q LS+TQ + ++ E MYQ +Q L+KY+ KQ+SVE+ L QLQS+N+L +
Sbjct: 728 KEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQ 787
Query: 1054 QQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERM 1113
QQ +DA KKA++QEKT IQ + + LQAE K L+E NK LM E LKER
Sbjct: 788 QQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRK----LEENNKGLMKECTLLKERQ 843
Query: 1114 DQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKA----IQKQCETLQK 1169
Q EKEK R++ + Q V DA N+ L L+ L ++ + ++L+K
Sbjct: 844 CQYEKEKEEREVVRRQLQREVD------DALNKQLLLEAMLEISSERRINLEDEAQSLKK 897
Query: 1170 NKKQLKQEV 1178
Q++ +V
Sbjct: 898 KLGQMRSQV 906
Score = 69.3 bits (168), Expect = 2e-11
Identities = 138/673 (20%), Positives = 277/673 (41%), Gaps = 105/673 (15%)
Query: 623 EQLRMEYKDSASLPRIQDTFCLCEH--LLKLKNNHCDQLTVKLKQMENMVSVLQNELSET 680
EQ R+E +S S P++++ C + + +N H D ++ ++ ++N +
Sbjct: 284 EQERLEGCES-SQPQVEEKMKKCRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDN 342
Query: 681 KKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLY-NKDSEQLRIKEEECGKVVET 739
++ + E +D RLA K NE+ + +Y D + E+ + E
Sbjct: 343 HQSPGK--------ENGEFD-RLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDEL 393
Query: 740 KQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMA 799
N L+++ + + + +N + R ++DQ ++ +++
Sbjct: 394 PYSDDENFMLLIEQSGMECKDFVSLSKSKN------ATAACGRSIEDQKCYCERLKVKFQ 447
Query: 800 RKKMNSEISHRHQKEKDLF-----HEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIE 854
+ K N + + E D H++ ++++ LR + + + + E+ Y +DIE
Sbjct: 448 KMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKDIE 507
Query: 855 AVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEME 914
+K I++ T TE Q L +L E K + S N QN E E +
Sbjct: 508 ELK--------IMEEQYRTQTEVKKQSKLTLKSLEVELKTVRS---NSNQNFHTHERERD 556
Query: 915 SYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSN 974
++ +RD + AR L+L+ + + +K D+ ++ NE L + L
Sbjct: 557 LWQEN--HLMRD----EIAR-LRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKR 609
Query: 975 AES-----------KINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMY-Q 1022
E ++N L + L +E + R++ ++ +C+ + Q
Sbjct: 610 NEEALTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQ 669
Query: 1023 IEQSKLKKYIAKQESVEERLSQLQSEN---MLLRQQLDDAHKKANSQEKTSSTIQDQFHS 1079
+ SK +A Q +V E + N +L QQL A E TSS ++ + H
Sbjct: 670 RQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKA-------ESTSSGLETELHY 722
Query: 1080 AA-----KNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV 1134
K L E + +LS ++ +++ H+ + DQ EK RK Q++V
Sbjct: 723 EREALKEKTLHIEHMQGVLSRTQRR---LEDIEHMYQN-DQPILEKYVRK------QQSV 772
Query: 1135 PSRCLHLDAENEVLQLQ------------QTLFSMKA--------IQKQCETLQKNKKQL 1174
L ++N + Q Q +T+ +++ +Q +C L++N K L
Sbjct: 773 EDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGL 832
Query: 1175 KQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQ 1234
+E LK + E+ K E + ++ + ++E+++ LN+ +L L+ +S E+ +
Sbjct: 833 MKECTLLKE--RQCQYEKEKEE--REVVRRQLQREVDDALNKQLL-LEAMLEISSERRIN 887
Query: 1235 LREDNTTSIKTQM 1247
L ED S+K ++
Sbjct: 888 L-EDEAQSLKKKL 899
Score = 64.3 bits (155), Expect = 8e-10
Identities = 146/717 (20%), Positives = 282/717 (39%), Gaps = 121/717 (16%)
Query: 218 ESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEE 277
++ +EQD E+TSE EQERL+GCE+ QP Q E K C + + + + H S+
Sbjct: 269 QNSNSEQDLEMTSEGEQERLEGCESSQP----QVEEKMKKCRNKKMEVSRNV-HADDSD- 322
Query: 278 MWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPF-- 335
+ + + +I+++K R + ++ + S + VK +
Sbjct: 323 --------NYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFT 374
Query: 336 NLTNNIPG----CEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQSS 391
+ N+I G E+D S F EQ K+ + S S+ ++
Sbjct: 375 DDLNDISGSSEKTSEDDELPYSDDENFMLLIEQSGMECKDFV-------SLSKSKNATAA 427
Query: 392 SKFHLHENKLDCD---------NDNKPGIGHIFS-TDK-----NFHNDASTKKARNPEVV 436
+ + K C+ +N + + S TDK N KK N +
Sbjct: 428 CGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFI 487
Query: 437 MVEMKEDQ-------EFDLQMTKNMNQ------NSDSGSTNNYKSLKPKLENLSSLPPDS 483
+ + +E++ E D++ K M + S KSL+ +L+ + S +
Sbjct: 488 LQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQN 547
Query: 484 DRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSG 543
T E +L Q+ ++E+ L E +K ++ + +++E + N+ +L
Sbjct: 548 FHTHE--RERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEK 605
Query: 544 TLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEI 603
TL +++ L + I R + + + +E + +++ E +E +E+
Sbjct: 606 TLK------RNEEALTKTITR-----YSKELNVLMDENTMLNSELQKEKQSMSRLE-TEM 653
Query: 604 ASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKL 663
S C L+ ++ ++ R K L Q T HL + N+H L+ +L
Sbjct: 654 ESYRCRLAAALCDH------DQRQSSKRDLQL-AFQSTVNEWCHLQEDTNSHIQILSQQL 706
Query: 664 KQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDS 723
+ E+ S L+ EL ++ + L + ++ L + + + +Y D
Sbjct: 707 SKAESTSSGLETELHYEREALKEKTL-------HIEHMQGVLSRTQRRLEDIEHMYQNDQ 759
Query: 724 EQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARI 783
L K V +Q ++ L +L + NL L Q+ NDA+K+
Sbjct: 760 PILE-------KYVRKQQSVEDGLFQLQSQ------NL-LYQQQCNDARKKADN------ 799
Query: 784 LQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNK 843
Q++ + + Q + E +K+ +E + K L E +L+E K
Sbjct: 800 -QEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQC----------QYEK 848
Query: 844 QKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLN-NLTAENKILNSEL 899
+KE++ + +E +D LN++ L E +L+ S + NL E + L +L
Sbjct: 849 EKEEREVVRRQLQREVDD------ALNKQLLLEAMLEISSERRINLEDEAQSLKKKL 899
Score = 35.4 bits (80), Expect = 0.40
Identities = 103/579 (17%), Positives = 235/579 (40%), Gaps = 106/579 (18%)
Query: 744 KWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKM 803
++ + K L+ + DL + + ++ E +++++ + K++E++R
Sbjct: 258 EYKANKRCKSLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRNV- 316
Query: 804 NSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNL 863
H + D +++D + L +I K N Q K + + + K N
Sbjct: 317 -------HADDSDNYNDD------VDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNE 363
Query: 864 QKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAA 923
+ +K ++ T+ + SG + ++++ S+ EN L IE C+ +
Sbjct: 364 KSKVK-SQIYFTDDLNDISGSSEKTSEDDELPYSDDENFM-----LLIEQSGMECKDFVS 417
Query: 924 VRDCDQSQTARDLKLDFQRTRQEWVRLH-DKMKVDMSGLQAKNEILSEK-LSNAESKINS 981
+ + A ++ Q+ E +++ KMK ++S LQ ++LSE + ++S+ +
Sbjct: 418 LSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQ---KVLSETDKTKSQSEHQN 474
Query: 982 LQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEER 1041
LQ G++ L ++ L Q + ++ + E++Y+ + +LK I +++ +
Sbjct: 475 LQ----------GKKKLC--NLRFILQQQEEERIKAEELYEKDIEELK--IMEEQYRTQT 520
Query: 1042 LSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKE 1101
+ QS+ L +++ ++NS + FH+ E E+ L ++N
Sbjct: 521 EVKKQSKLTLKSLEVELKTVRSNSNQN--------FHTH------ERERD---LWQENHL 563
Query: 1102 LMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKAIQ 1161
+ DE L+ +D + + QET EN+ + ++ I+
Sbjct: 564 MRDEIARLRLEIDTIKHQN----------QET----------ENKYFK------DIEIIK 597
Query: 1162 KQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAILTL 1221
+ E L+K K+ ++ + + + + +L++E E L
Sbjct: 598 ENNEDLEKTLKRNEEALTKTITRYSKEL---------NVLMDENTMLNSE---------L 639
Query: 1222 QKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKELYL 1281
QK+ +Q + E S + ++ + D + S + Q F T + + L
Sbjct: 640 QKE-----KQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQST-VNEWCHLQE 693
Query: 1282 EEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSL 1320
+ + LS +LS+ + + T+L E+E + ++L
Sbjct: 694 DTNSHIQILSQQLSKAESTSSGLETELHYEREALKEKTL 732
Score = 30.8 bits (68), Expect = 9.7
Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 7/62 (11%)
Query: 52 SWWKNSVGSESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRD 111
+W KN + P + VR +DLG +H+AA +GDV V + ++ RD
Sbjct: 17 TWRKN-------RDKDGFSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRD 69
Query: 112 RK 113
+K
Sbjct: 70 KK 71
>gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH
polyclonal antibodies [Homo sapiens]
Length = 1430
Score = 371 bits (952), Expect = e-102
Identities = 252/667 (37%), Positives = 369/667 (55%), Gaps = 63/667 (9%)
Query: 560 QQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFM 619
Q + GE R ++ N + +VKNQI+ D D ++ S+ SED + +N +
Sbjct: 810 QDLEMASEGEQKR-LEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVI 868
Query: 620 LLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSE 679
LLI+Q M+ KD L +I+ TFCLC+ L +LK+NHC+QL VK+++++N SVLQ LSE
Sbjct: 869 LLIDQHEMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSE 928
Query: 680 TKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVET 739
++ K QL+ + +E EKEL LR A++QE +++RN + L+ K E+LRI EE+ +
Sbjct: 929 KEEIKSQLKHETLELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADV 988
Query: 740 KQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMA 799
+ +K L+ EL+T NN + V D ++ L E R++QD
Sbjct: 989 TKPIKPALKSAEVELKTGGNNSNQV--SETDEKEDLLHEN--RLMQD------------- 1031
Query: 800 RKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEK 859
EIA LRLE DTIKNQN EKKY +D E VK K
Sbjct: 1032 ---------------------------EIARLRLEKDTIKNQN--LEKKYLKDFEIVKRK 1062
Query: 860 NDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCR 919
+++LQK +K NEETL ETI YSGQL LT EN L S+LE +++ +RLE EM+SYRCR
Sbjct: 1063 HEDLQKALKRNEETLAETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEMQSYRCR 1122
Query: 920 LAAAVRDCDQSQTA-RDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESK 978
L AA+ D DQS ++ RD +L FQ T + L + L + ILS +LS AESK
Sbjct: 1123 LNAALCDHDQSHSSKRDQELAFQGTVDKCCHLQE-------NLNSHVLILSLQLSKAESK 1175
Query: 979 INSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESV 1038
L+ +LH T +AL ++L+ E VQ +L Q Q Q K+ E+MY+ + ++K I KQ
Sbjct: 1176 FRVLETELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ--- 1232
Query: 1039 EERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEK 1098
ER QL+ +NMLL+QQLDDA KA++QEK IQ + + +NLQAE K L L+E
Sbjct: 1233 -ERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLLEED 1291
Query: 1099 NKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQL--QQTLFS 1156
NK L++E NH KE+ Q EKEKA R++ + + Q+ A +L + ++
Sbjct: 1292 NKMLVNELNHSKEKKCQYEKEKAEREVAVRQLQQKQDDVLNKRSATKALLDASSRHCIYL 1351
Query: 1157 MKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNE 1216
+Q + L + + Q ++ L + + G A+ KL +E ++I +K +E
Sbjct: 1352 ENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDAQ--KLEVENVMMRKIIKKQDE 1409
Query: 1217 AILTLQK 1223
I +K
Sbjct: 1410 QIERFEK 1416
Score = 76.3 bits (186), Expect = 2e-13
Identities = 165/839 (19%), Positives = 325/839 (38%), Gaps = 149/839 (17%)
Query: 112 RKKSIQQLVPEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSM 171
+K S+ + E K+ Q ++ P T D ++ +K +K +VSP
Sbjct: 686 KKDSVSNIATEIKDGQIRGTVSSQRQPALKATG-DEKDSVSNIAREIKDGEKSGTVSPQK 744
Query: 172 PENQSAT--KELGQMNLTER------------EKMDTGVVLLSGNDTLHDLCQSQLPENK 217
Q K++ +N+ R E + T + +++ + +++ + +
Sbjct: 745 QSAQKVIFKKKVSLLNIATRITGGWKSGTEYPENLPTLKATIENKNSVLNTA-TKMKDVQ 803
Query: 218 ESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEE 277
S AEQD E+ SE EQ+RL+ EN QPQ +Q + D +DI +Q S+
Sbjct: 804 TSTPAEQDLEMASEGEQKRLEEYENNQPQVKNQ---IHSRDDLDDI--------IQSSQT 852
Query: 278 MWIEQGKL--EWKNQLKLVINELKQRFGEIYEKYKIP----ACPEEEPLLDNSTRGTDVK 331
+ + L KN + L+I++ + + + KI C L DN VK
Sbjct: 853 VSEDGDSLCCNCKNVI-LLIDQHEMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQLRVK 911
Query: 332 DIPFNLTNNIPGCEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQSS 391
++ + EI + ET +KE +C S
Sbjct: 912 IRKLKNKASVLQKRLSEKEEIKSQLKHETLELEKE--------------------LC--S 949
Query: 392 SKFHLHENKLDCDNDNKPGIGHIFSTDKNFHNDASTKKARNPEVVMVEMKEDQEFDLQMT 451
+F + + K KK RN E + +++E L++T
Sbjct: 950 LRFAIQQEK---------------------------KKRRNVEELHQKVRE----KLRIT 978
Query: 452 KNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEE 511
+ + + +LK L + +S++ SE E+L + + ++E+ L
Sbjct: 979 EEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRL 1038
Query: 512 EFLALKKEDVQLH--KDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGLNQQIPRKENGE 569
E +K ++++ KD E KH L N++ +
Sbjct: 1039 EKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALK---------------RNEETLAETIAC 1083
Query: 570 HDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEY 629
+ ++E +++++ + + +E +E+ S C L+ ++ ++ +Q
Sbjct: 1084 YSGQLAALTDENTTLRSKLEKQRESGQRLE-TEMQSYRCRLNAALCDH-----DQSHSSK 1137
Query: 630 KDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLEL 689
+D Q T C HL + N+H L+++L + E+ VL+ EL T + L+
Sbjct: 1138 RDQEL--AFQGTVDKCCHLQENLNSHVLILSLQLSKAESKFRVLETELHYTGEA---LKE 1192
Query: 690 QKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRR 749
+ + +E ++ LKQ+ + ++ + +Y + E+C + E QLK
Sbjct: 1193 KALVFE----HVQSELKQKQSQMKDIEKMYKSGYNTM----EKCIEKQERFCQLKKQNML 1244
Query: 750 LVKELRTVRNNLD------LVVQERNDA----------QKQLSEEQDARILQDQILTSKQ 793
L ++L RN D L +Q R DA + +L E+D ++L +++ SK+
Sbjct: 1245 LQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLLEEDNKMLVNELNHSKE 1304
Query: 794 KELEMARKKMNSEISHR--HQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFE 851
K+ + ++K E++ R QK+ D+ ++ + + ++N + KK +
Sbjct: 1305 KKCQYEKEKAEREVAVRQLQQKQDDVLNKRSATKALLDASSRHCIYLENGMQDSRKKLDQ 1364
Query: 852 DIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLE 910
+E D L I+ +E G L EN ++ ++ + ER E
Sbjct: 1365 MRSQFQEIQDQLTATIRCTKE--------MEGDAQKLEVENVMMRKIIKKQDEQIERFE 1415
>gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH
polyclonal antibodies [Homo sapiens]
Length = 868
Score = 367 bits (941), Expect = e-101
Identities = 250/675 (37%), Positives = 370/675 (54%), Gaps = 79/675 (11%)
Query: 560 QQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFM 619
Q + GE R ++ N + +VKNQI+ D D ++ S+ SED + +N +
Sbjct: 248 QDLEMASEGEQKR-LEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVI 306
Query: 620 LLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSE 679
LLI+Q M+ KD L +I+ TFCLC+ L +LK+NHC+QL VK+++++N SVLQ LSE
Sbjct: 307 LLIDQHEMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSE 366
Query: 680 TKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVET 739
++ K QL+ + +E EKEL LR A++QE +++RN + L+ K E+LRI EE+ +
Sbjct: 367 KEEIKSQLKHETLELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADV 426
Query: 740 KQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMA 799
+ +K L+ EL+T NN + V D ++ L E R++QD
Sbjct: 427 TKPIKPALKSAEVELKTGGNNSNQV--SETDEKEDLLHEN--RLMQD------------- 469
Query: 800 RKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEK 859
EIA LRLE DTIKNQN EKKY +D E VK K
Sbjct: 470 ---------------------------EIARLRLEKDTIKNQN--LEKKYLKDFEIVKRK 500
Query: 860 NDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCR 919
+++LQK +K NEETL ETI YSGQL LT EN L S+LE +++ +RLE EM+SYRCR
Sbjct: 501 HEDLQKALKRNEETLAETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEMQSYRCR 560
Query: 920 LAAAVRDCDQSQTA-RDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESK 978
L AA+ D DQS ++ RD +L FQ T + L + L + ILS +LS AESK
Sbjct: 561 LNAALCDHDQSHSSKRDQELAFQGTVDKCCHLQE-------NLNSHVLILSLQLSKAESK 613
Query: 979 INSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESV 1038
L+ +LH T +AL ++L+ E VQ +L Q Q Q K+ E+MY+ + ++K I KQ
Sbjct: 614 FRVLETELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ--- 670
Query: 1039 EERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEK 1098
ER QL+ +NMLL+QQLDDA KA++QEK IQ + + +NLQAE K L L+E
Sbjct: 671 -ERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLLEED 729
Query: 1099 NKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQL-QQTLFSM 1157
NK L++E H KE+ Q EKEKA R++ + + Q+ ++VL T +
Sbjct: 730 NKMLVNELTHSKEKECQYEKEKAEREVAVRQLQQ----------KRDDVLNKGSATKALL 779
Query: 1158 KAIQKQCETLQKNKKQLKQEVVNLKSYMER---------NMLERGKAEWHKLLIEERARK 1208
A + C L+ + ++++ ++S + + + + KL +E +
Sbjct: 780 DASSRHCTYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDAQKLEVENVMMR 839
Query: 1209 EIEEKLNEAILTLQK 1223
+I +K +E I +K
Sbjct: 840 KIIKKQDEQIERFEK 854
Score = 79.0 bits (193), Expect = 3e-14
Identities = 166/839 (19%), Positives = 324/839 (38%), Gaps = 149/839 (17%)
Query: 112 RKKSIQQLVPEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSM 171
+K S+ + E K+ Q ++ P T D ++ +K +K +VSP
Sbjct: 124 KKDSVSNIATEIKDGQIRGTVSSQRQPALKATG-DEKDSVSNIAREIKDGEKSGTVSPQK 182
Query: 172 PENQSAT--KELGQMNLTER------------EKMDTGVVLLSGNDTLHDLCQSQLPENK 217
Q K++ +N+ R E + T + +++ + +++ + +
Sbjct: 183 QSAQKVIFKKKVSLLNIATRITGGWKSGTEYPENLPTLKATIENKNSVLNTA-TKMKDVQ 241
Query: 218 ESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEE 277
S AEQD E+ SE EQ+RL+ EN QPQ +Q + D +DI +Q S+
Sbjct: 242 TSTPAEQDLEMASEGEQKRLEEYENNQPQVKNQ---IHSRDDLDDI--------IQSSQT 290
Query: 278 MWIEQGKL--EWKNQLKLVINELKQRFGEIYEKYKIP----ACPEEEPLLDNSTRGTDVK 331
+ + L KN + L+I++ + + + KI C L DN VK
Sbjct: 291 VSEDGDSLCCNCKNVI-LLIDQHEMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQLRVK 349
Query: 332 DIPFNLTNNIPGCEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQSS 391
++ + EI + ET +KE +C S
Sbjct: 350 IRKLKNKASVLQKRLSEKEEIKSQLKHETLELEKE--------------------LC--S 387
Query: 392 SKFHLHENKLDCDNDNKPGIGHIFSTDKNFHNDASTKKARNPEVVMVEMKEDQEFDLQMT 451
+F + + K KK RN E + +++E L++T
Sbjct: 388 LRFAIQQEK---------------------------KKRRNVEELHQKVRE----KLRIT 416
Query: 452 KNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEE 511
+ + + +LK L + +S++ SE E+L + + ++E+ L
Sbjct: 417 EEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRL 476
Query: 512 EFLALKKEDVQLH--KDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGLNQQIPRKENGE 569
E +K ++++ KD E KH L N++ +
Sbjct: 477 EKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALK---------------RNEETLAETIAC 521
Query: 570 HDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEY 629
+ ++E +++++ + + +E +E+ S C L+ ++ ++ +Q
Sbjct: 522 YSGQLAALTDENTTLRSKLEKQRESGQRLE-TEMQSYRCRLNAALCDH-----DQSHSSK 575
Query: 630 KDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLEL 689
+D Q T C HL + N+H L+++L + E+ VL+ EL T + L+
Sbjct: 576 RDQEL--AFQGTVDKCCHLQENLNSHVLILSLQLSKAESKFRVLETELHYTGEA---LKE 630
Query: 690 QKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRR 749
+ + +E ++ LKQ+ + ++ + +Y + E+C + E QLK
Sbjct: 631 KALVFE----HVQSELKQKQSQMKDIEKMYKSGYNTM----EKCIEKQERFCQLKKQNML 682
Query: 750 LVKELRTVRNNLD------LVVQERNDA----------QKQLSEEQDARILQDQILTSKQ 793
L ++L RN D L +Q R DA + +L E+D ++L +++ SK+
Sbjct: 683 LQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLLEEDNKMLVNELTHSKE 742
Query: 794 KELEMARKKMNSEISHR--HQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFE 851
KE + ++K E++ R QK D+ ++ + + ++N + KK +
Sbjct: 743 KECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQ 802
Query: 852 DIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLE 910
+E D L I+ +E G L EN ++ ++ + ER E
Sbjct: 803 MRSQFQEIQDQLTATIRCTKE--------MEGDAQKLEVENVMMRKIIKKQDEQIERFE 853
>gi|124517695 ankyrin repeat domain 36B [Homo sapiens]
Length = 1121
Score = 362 bits (930), Expect = 1e-99
Identities = 279/856 (32%), Positives = 431/856 (50%), Gaps = 118/856 (13%)
Query: 401 LDCDNDNKPGIGHIFSTDKNFHNDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDS 460
L +D K + +I + K+ + + P +K+D ++ Q +
Sbjct: 337 LKATSDKKDSVSNIPTEIKDGQQSGTVSSQKQPAWKATSVKKDSVSNIATEIKDGQIRGT 396
Query: 461 GSTNNYKSLKP------KLENLSSLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFL 514
S+ +LK + N++ D +++ V ++ Q + FK +V+ L
Sbjct: 397 VSSQRRPALKTTGDEKDSVSNIAREIKDGEKSGTVSPQKQSAQKVI-FKKKVSLL----- 450
Query: 515 ALKKEDVQLHKDVEEEMEKHRSNSTELSGTL-TDGTTVGNDDDGLNQQIPRKE------- 566
++ + + TE L T T+ N D LN KE
Sbjct: 451 -----------NIATRITGGGKSGTEYPENLRTLKATIENKDSVLNTATKMKEVQTSTPA 499
Query: 567 --------NGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENF 618
GE R ++ N + +VKNQI+ D D ++ S+ SED + +N
Sbjct: 500 EQDLEMASEGEQKR-LEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNV 558
Query: 619 MLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELS 678
+LLI+Q M+ KD L +I++TFCL + L+KLK+NHC+QL VK+++++N SVLQ +S
Sbjct: 559 ILLIDQHEMKCKDCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRIS 618
Query: 679 ETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVE 738
E ++ K QL+ + +E EKEL LR A++QE +++RN + L+ K E+LRI EE+ +
Sbjct: 619 EKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEAD 678
Query: 739 TKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEM 798
+ +K L+ EL+T NN + V D ++ L E R++QD
Sbjct: 679 VTKPIKPALKSAEVELKTGGNNSNQV--SETDEKEDLLHEN--RLMQD------------ 722
Query: 799 ARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKE 858
EIA LRLE DTIKNQN EKKY +D E VK
Sbjct: 723 ----------------------------EIARLRLEKDTIKNQN--LEKKYLKDFEIVKR 752
Query: 859 KNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRC 918
K+++LQK +K N ETL +TI YSGQL LT EN L S+LE +++++RLE EM+SYRC
Sbjct: 753 KHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYRC 812
Query: 919 RLAAAVRDCDQSQTA-RDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAES 977
RL AA D DQS ++ RD +L FQ T DK + L + ILS +LS AES
Sbjct: 813 RLNAARCDHDQSHSSKRDQELAFQGT-------VDKCRHLQENLNSHVLILSLQLSKAES 865
Query: 978 KINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQES 1037
K L+ +LH T +AL ++L+ E VQ +L Q Q Q K+ E+MY+ + ++K I KQ
Sbjct: 866 KSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ-- 923
Query: 1038 VEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQE 1097
ER QL+ +NMLL+QQLDDA KA++QEK IQ + + +NLQAE K L L+E
Sbjct: 924 --ERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEE 981
Query: 1098 KNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQL-QQTLFS 1156
NK L++E NH KE+ Q EKEKA R++ + + Q+ ++VL T
Sbjct: 982 DNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQ----------KRDDVLNKGSATKAL 1031
Query: 1157 MKAIQKQCETLQKNKKQLKQEVVNLKSYMER---------NMLERGKAEWHKLLIEERAR 1207
+ A + C L+ + ++++ ++S + + + + KL +E
Sbjct: 1032 LDASSRHCTYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMM 1091
Query: 1208 KEIEEKLNEAILTLQK 1223
++I +K ++ I L+K
Sbjct: 1092 RKIIKKQDDQIERLEK 1107
Score = 52.8 bits (125), Expect = 2e-06
Identities = 155/834 (18%), Positives = 299/834 (35%), Gaps = 139/834 (16%)
Query: 112 RKKSIQQLVPEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSM 171
+K S+ + E K+ Q ++ P T D ++ +K +K +VSP
Sbjct: 377 KKDSVSNIATEIKDGQIRGTVSSQRRPALKTTG-DEKDSVSNIAREIKDGEKSGTVSPQK 435
Query: 172 PENQSAT--KELGQMNLTER------------EKMDTGVVLLSGNDTLHDLCQSQLPENK 217
Q K++ +N+ R E + T + D++ + +++ E +
Sbjct: 436 QSAQKVIFKKKVSLLNIATRITGGGKSGTEYPENLRTLKATIENKDSVLNTA-TKMKEVQ 494
Query: 218 ESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEE 277
S AEQD E+ SE EQ+RL+ EN QPQ +Q + D +DI +Q S+
Sbjct: 495 TSTPAEQDLEMASEGEQKRLEEYENNQPQVKNQ---IHSRDDLDDI--------IQSSQT 543
Query: 278 MWIEQGKL--EWKNQLKLV-INELKQRFGEIYEKYKIPACPEEE--PLLDNSTRGTDVKD 332
+ + L KN + L+ +E+K + K K C + L DN VK
Sbjct: 544 VSEDGDSLCCNCKNVILLIDQHEMKCKDCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKI 603
Query: 333 IPFNLTNNIPGCEEEDASEISVSVVFETFPEQKE-PSLKNIIHPYYHPYSGSQEHVCQSS 391
++ + EI + E +KE SL+ I +E +
Sbjct: 604 RKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEELHQKVR 663
Query: 392 SKFHLHEN----KLDCDNDNKPGIGHI---FSTDKNFHNDASTKKARNPEVVMVEMKEDQ 444
K + E + D KP + T N N S + + + +D+
Sbjct: 664 EKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDE 723
Query: 445 EFDLQMTKN--MNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTSEVYLHEELQQDMQKF 502
L++ K+ NQN + +++ +K K E+ L + L+++ +
Sbjct: 724 IARLRLEKDTIKNQNLEKKYLKDFEIVKRKHED---------------LQKALKRNGETL 768
Query: 503 KNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGLNQQI 562
+ + AL E+ L +E++ E + TE+ D D +
Sbjct: 769 AKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYRCRLNAARCDHD-QSHSS 827
Query: 563 PRKENGEHDRPADKTSN-EKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLL 621
R + DK + ++N + + + + S + + + + L+
Sbjct: 828 KRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALV 887
Query: 622 IEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELS--- 678
E ++ E K S ++K +E M N +
Sbjct: 888 FEHVQSELKQKQS---------------------------QMKDIEKMYKSGYNTMEKCI 920
Query: 679 ETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVE 738
E ++ QL+ Q + +++L D R K +N+EK ++ D+ +++ + EC K
Sbjct: 921 EKQERFCQLKKQNMLLQQQLDDAR--NKADNQEKAILNIQARCDA-RVQNLQAECRK--- 974
Query: 739 TKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEM 798
+L E+D ++L +++ SK+KE +
Sbjct: 975 ----------------------------------HRLLLEEDNKMLVNELNHSKEKECQY 1000
Query: 799 ARKKMNSEISHR--HQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAV 856
++K E++ R QK D+ ++ + + ++N + KK +
Sbjct: 1001 EKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSQF 1060
Query: 857 KEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLE 910
+E D L I+ +E G L E+ ++ ++ ERLE
Sbjct: 1061 QEIQDQLTATIRCTKE--------MEGDTQKLEVEHVMMRKIIKKQDDQIERLE 1106
>gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]
Length = 1524
Score = 360 bits (924), Expect = 5e-99
Identities = 330/1189 (27%), Positives = 554/1189 (46%), Gaps = 167/1189 (14%)
Query: 111 DRKKSIQQLVPEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPS 170
D + S+ + E K+ + ++ P T D + +K +K +VS
Sbjct: 413 DEEDSVSNIATEIKDGEKSGTVSSQKQPALKATT-DEKDSVSNIATEIKDGEKSGTVSSQ 471
Query: 171 MPENQSATK-ELGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEA------- 222
P +AT E G + RE D + T+ + L + K++
Sbjct: 472 KPPALTATSDEEGSVLSIARENKDG-----EKSRTVSSRKKPALKATSDEKDSFSNITRG 526
Query: 223 EQDSELT---SEEEQERLKGCENKQPQ-----KTSQEPEMAKDCDREDIPIYPVLPHVQK 274
++D E++ S ++ LKG +++ + +++ E ++ E P +K
Sbjct: 527 KKDGEISRKVSSQKPPTLKGTSDEEDSVLGIARENKDGEKSRTVSSEKPPGLKA-SSAEK 585
Query: 275 SEEMWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIP 334
+ I +GK + + ++ + K + A +E+ N TR +I
Sbjct: 586 DSVLNIARGKKDGEKTKRVSSRK----------KPSLEATSDEKDSFSNITREKKDGEIS 635
Query: 335 FNLTNNIP----GCEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQS 390
+++ P G +E+ S + ++ E +K ++ + P S ++ V
Sbjct: 636 RKVSSQKPPALKGTSDEEDSVLGIAR--ENKDGEKSRTVSSEKPPGLKATSDEKDSVLNI 693
Query: 391 SSKFHLHENKLDCDNDNKPGIGHIFSTDKNFHNDASTKK----------ARNPEVVMVEM 440
+ E + +P + I + + N A+ KK + P +
Sbjct: 694 ARGKKDGEKTRTVSSPKQPALKAICDKEDSVPNMATEKKDEQISGTVSCQKQPALKATSD 753
Query: 441 KEDQEFDLQMTKNMNQNSDSGSTNN---YKSLKPKLENLSSLPPDSDRTSEVYLHEELQQ 497
K+D ++ Q S + S+ +K+ K +++S++ + + ++ L+
Sbjct: 754 KKDSVSNIPTEIKDGQQSGTVSSQKQPAWKATSVKKDSVSNIATEI-KDGQIRGTGILEY 812
Query: 498 DMQKFKNEVNTLEEEFLALKK------EDVQLHKDVEEEMEKHRSNSTELSGTLTDGT-- 549
F + +EE+F +L K + K + ++ + +T ++G GT
Sbjct: 813 T---FNVMFDQIEEKFTSLNKSAGVSPQKQSAQKVIFKKKVSLLNIATRITGGWKSGTEY 869
Query: 550 ---------TVGNDDDGLN---------------QQIPRKENGEHDRPADKTSNEKNEVK 585
T+ N + LN Q + GE R ++ N + +VK
Sbjct: 870 PENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKR-LEEYENNQPQVK 928
Query: 586 NQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLC 645
NQI+ D D ++ S+ SED + +N +LLI+Q M+ KD L +I++TFCL
Sbjct: 929 NQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVHLLKIKNTFCLW 988
Query: 646 EHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLAL 705
+ L+KLK+NHC+QL VK+++++N SVLQ +SE ++ K QL+ + +E EKEL LR A+
Sbjct: 989 KRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAI 1048
Query: 706 KQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVV 765
+QE +++RN + ++ K E+LRI EE+ + + +K L+ EL+T NN + V
Sbjct: 1049 QQEKKKRRNVEEVHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQV- 1107
Query: 766 QERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQ 825
D ++ L E R++QD
Sbjct: 1108 -SETDEKEDLLHEN--RLMQD--------------------------------------- 1125
Query: 826 EEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQL 885
EIA LRLE DTIKNQN EKKY +D E VK K+++LQK +K N ETL +TI YSGQL
Sbjct: 1126 -EIARLRLEKDTIKNQN--LEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQL 1182
Query: 886 NNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTA-RDLKLDFQRTR 944
LT EN L S+LE +++++RLE EM+SY CRL AA D DQS ++ RD +L FQ T
Sbjct: 1183 AALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGT- 1241
Query: 945 QEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQ 1004
DK + L + ILS +LS AESK L+ +LH T +AL ++L+ E VQ
Sbjct: 1242 ------VDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQ 1295
Query: 1005 RDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKAN 1064
+L Q Q Q K+ E+MY+ + ++K I KQ ER QL+ +NMLL+QQLDDA KA+
Sbjct: 1296 SELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLKKQNMLLQQQLDDARNKAD 1351
Query: 1065 SQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRK 1124
+QEK IQ + + +NLQAE K L L+E NK L++E NH KE+ Q EKEKA R+
Sbjct: 1352 NQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAERE 1411
Query: 1125 IDLTEAQETVPSRCLHLDAENEVLQL-QQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKS 1183
+ + + Q+ ++VL T + A + C L+ + ++++ ++S
Sbjct: 1412 VAVRQLQQ----------KRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRS 1461
Query: 1184 YMER---------NMLERGKAEWHKLLIEERARKEIEEKLNEAILTLQK 1223
+ + + + KL +E ++I +K ++ I L+K
Sbjct: 1462 QFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEK 1510
>gi|115495445 ankyrin repeat domain 30A [Homo sapiens]
Length = 1341
Score = 343 bits (880), Expect = 7e-94
Identities = 212/500 (42%), Positives = 300/500 (60%), Gaps = 55/500 (11%)
Query: 622 IEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETK 681
++++ + +DS SL +I DT CE +L+ +HC+Q T K++QM+ VL+ +LSE K
Sbjct: 892 MDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTGKMEQMKKKFCVLKKKLSEAK 951
Query: 682 KTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQ 741
+ K QLE QK++WE+EL +RL L QE E++RNAD+L K E+L EE+ K +E KQ
Sbjct: 952 EIKSQLENQKVKWEQELCSVRLTLNQEEEKRRNADILNEKIREELGRIEEQHRKELEVKQ 1011
Query: 742 QLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARK 801
QL+ LR EL++V +NL+
Sbjct: 1012 QLEQALRIQDIELKSVESNLN--------------------------------------- 1032
Query: 802 KMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKND 861
++SH H+ E L HE+CML++EIA+L+LEI T+K+Q ++KE KYFEDI+ +KEKN
Sbjct: 1033 ----QVSHTHENENYLLHENCMLKKEIAMLKLEIATLKHQYQEKENKYFEDIKILKEKNA 1088
Query: 862 NLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLA 921
LQ +KL EE+LT+ QYSGQL L AEN +L S+L+ KQ++E LE E+ES+ RLA
Sbjct: 1089 ELQMTLKLKEESLTKRASQYSGQLKVLIAENTMLTSKLKE-KQDKEILEAEIESHHPRLA 1147
Query: 922 AAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINS 981
+AV+D DQ T+R + + L KM VD+S NE+L + LS A+ K S
Sbjct: 1148 SAVQDHDQIVTSRKSQEPAFHIAGD-ACLQRKMNVDVSSTIYNNEVLHQPLSEAQRKSKS 1206
Query: 982 LQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEER 1041
L+I L+ DAL +L+ E QRD +TQCQ KE E MYQ EQ + K+ +QES++++
Sbjct: 1207 LKINLNYAGDALRENTLVSEHAQRDQRETQCQMKEAEHMYQNEQDNVNKHTEQQESLDQK 1266
Query: 1042 LSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKE 1101
L QLQS+NM L+QQL AHKKA+++ K TI F E + Q L+EKN+E
Sbjct: 1267 LFQLQSKNMWLQQQLVHAHKKADNKSKI--TIDIHF--------LERKMQHHLLKEKNEE 1316
Query: 1102 LMDEYNHLKERMDQCEKEKA 1121
+ + NHLK R+ Q EKEKA
Sbjct: 1317 IFNYNNHLKNRIYQYEKEKA 1336
Score = 47.4 bits (111), Expect = 1e-04
Identities = 130/707 (18%), Positives = 274/707 (38%), Gaps = 129/707 (18%)
Query: 767 ERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSE-----ISHR--------HQK 813
+++ K L + + + D+IL S+ K+ + ++E +S + HQK
Sbjct: 593 QKSVPNKALELKNEQTLRADEILPSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQK 652
Query: 814 EKD--------------LFHEDCMLQEEI---ALLRLEIDTIKNQNKQKEKKYFEDIE-- 854
E D L +C ++ I AL +++ T K + +K + IE
Sbjct: 653 EIDKINGKLEGSPVKDGLLKANCGMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQ 712
Query: 855 ------AVKEKNDNLQKIIKL---------------NEETLTETILQYSGQLNNLTAENK 893
A++ KN+ + ++ + E+L ET+ Q L T + +
Sbjct: 713 KSVPNKALELKNEQTLRADEILPSESKQKDYEESSWDSESLCETVSQKDVCLPKATHQKE 772
Query: 894 I--LNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQE----- 946
I +N +LE N L+ CR+ ++ A +L +D Q + E
Sbjct: 773 IDKINGKLEESPDNDGFLKAP-----CRMKVSI-----PTKALEL-MDMQTFKAEPPEKP 821
Query: 947 ---WVRLHDKMKVDMSGLQAKNE--ILSEKLSNAES---KINSLQIQLHNTRDALGRESL 998
+ + V L+ KNE + ++++ +ES K+ + R+ + ++ +
Sbjct: 822 SAFEPAIEMQKSVPNKALELKNEQTLRADQMFPSESKQKKVEENSWDSESLRETVSQKDV 881
Query: 999 I---------LERVQRDLSQTQCQKKETEQMYQIEQSK-LKKYIAKQESVEERLSQLQSE 1048
++++ L + K + ++ E+++ L+K +Q + ++ Q++ +
Sbjct: 882 CVPKATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRT--GKMEQMKKK 939
Query: 1049 NMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNH 1108
+L+++L +A + + E + + S L E EK+ +N ++++E
Sbjct: 940 FCVLKKKLSEAKEIKSQLENQKVKWEQELCSVRLTLNQEEEKR------RNADILNE--K 991
Query: 1109 LKERMDQCEKEKAGRKIDLTEAQETVPSRCLHL-DAENEVLQLQQTLFSMKAIQKQCETL 1167
++E + + E++ + ++ + + + L E+ + Q+ T + + + L
Sbjct: 992 IREELGRIEEQHRKELEVKQQLEQALRIQDIELKSVESNLNQVSHTHENENYLLHENCML 1051
Query: 1168 QKNKKQLKQEVVNLK-SYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAILTLQKQAA 1226
+K LK E+ LK Y E+ E E K+L E+ A ++ KL E LT K+A+
Sbjct: 1052 KKEIAMLKLEIATLKHQYQEK---ENKYFEDIKILKEKNAELQMTLKLKEESLT--KRAS 1106
Query: 1227 VSHEQLVQLREDNT-----TSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKEL-- 1279
QL L +NT K E+ ++ES R+ ++ D ++ R +
Sbjct: 1107 QYSGQLKVLIAENTMLTSKLKEKQDKEILEAEIESHHPRLASAVQDHDQIVTSRKSQEPA 1166
Query: 1280 ----------------YLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSLFTA 1323
+ E L LS + L + R +L +
Sbjct: 1167 FHIAGDACLQRKMNVDVSSTIYNNEVLHQPLSEAQRKSKSLKINLNYAGDALRENTLVSE 1226
Query: 1324 YATRPVLESPCVGNLNDSEGLNRKHIPRKKRSALKDMESYLLKMQQK 1370
+A R E+ C + N + K + ++ L ++Q K
Sbjct: 1227 HAQRDQRETQCQMKEAEHMYQNEQDNVNKHTEQQESLDQKLFQLQSK 1273
Score = 44.3 bits (103), Expect = 9e-04
Identities = 86/451 (19%), Positives = 179/451 (39%), Gaps = 84/451 (18%)
Query: 764 VVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSE-----ISHR-------- 810
+ +++ K L + + + D+IL S+ K+ + +SE +S +
Sbjct: 709 IEMQKSVPNKALELKNEQTLRADEILPSESKQKDYEESSWDSESLCETVSQKDVCLPKAT 768
Query: 811 HQKEKD--------------LFHEDCMLQEEI---ALLRLEIDTIKNQNKQKEKKYFEDI 853
HQKE D C ++ I AL +++ T K + +K + I
Sbjct: 769 HQKEIDKINGKLEESPDNDGFLKAPCRMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAI 828
Query: 854 EAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEM 913
E K + K ++L E + + E +SE +Q+ + +
Sbjct: 829 EMQKSVPN---KALELKNEQTLRADQMFPSESKQKKVEENSWDSESLRETVSQKDVCVPK 885
Query: 914 ESYR---CRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSE 970
+++ +++ + D D +R R+ ++ M ++ K +L +
Sbjct: 886 ATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTGKMEQMKKKFCVLKK 945
Query: 971 KLSNA--------------ESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQ-KK 1015
KLS A E ++ S+++ L+ + ++ E+++ +L + + Q +K
Sbjct: 946 KLSEAKEIKSQLENQKVKWEQELCSVRLTLNQEEEKRRNADILNEKIREELGRIEEQHRK 1005
Query: 1016 ETEQMYQIEQSKLKKYIAKQESVEERLSQL----QSENMLLRQ-----------QLDDAH 1060
E E Q+EQ+ L+ + +SVE L+Q+ ++EN LL + +L+ A
Sbjct: 1006 ELEVKQQLEQA-LRIQDIELKSVESNLNQVSHTHENENYLLHENCMLKKEIAMLKLEIAT 1064
Query: 1061 KKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEK 1120
K QEK + +D I L+EKN EL +E + + +
Sbjct: 1065 LKHQYQEKENKYFED----------------IKILKEKNAELQMTLKLKEESLTKRASQY 1108
Query: 1121 AGRKIDLTEAQETVPSRCLHLDAENEVLQLQ 1151
+G ++ + A+ T+ + L + E+L+ +
Sbjct: 1109 SG-QLKVLIAENTMLTSKLKEKQDKEILEAE 1138
>gi|169163827 PREDICTED: similar to UPF0634 protein KIAA1641 [Homo
sapiens]
Length = 475
Score = 323 bits (828), Expect = 7e-88
Identities = 208/498 (41%), Positives = 293/498 (58%), Gaps = 58/498 (11%)
Query: 631 DSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQ 690
D L +I++TFCL + L+KLK+NHC+QL VK+++++N SVLQ +SE ++ K QL+ +
Sbjct: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
Query: 691 KIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRL 750
+E EKEL LR A++QE +++RN + L+ K E+LRI EE+ + + +K L+
Sbjct: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
Query: 751 VKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHR 810
EL+T NN + V D ++ L E R++QD
Sbjct: 144 EVELKTGGNNSNQV--SETDEKEDLLHEN--RLMQD------------------------ 175
Query: 811 HQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLN 870
EIA LRL+ DTIKNQN EKKY +D E VK K+++LQK +K N
Sbjct: 176 ----------------EIARLRLDTDTIKNQN--LEKKYLKDFEIVKRKHEDLQKALKRN 217
Query: 871 EETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQS 930
ETL +TI YSGQL LT EN L S+LE +++++RLE EM+SY CRL AA D DQS
Sbjct: 218 GETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQS 277
Query: 931 QTA-RDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNT 989
++ RD +L FQ T DK + L + ILS +LS AESK L+ +LH T
Sbjct: 278 HSSKRDQELAFQGT-------VDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYT 330
Query: 990 RDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSEN 1049
+AL ++L+ E VQ +L Q Q Q K+ E+MY+ + ++K I KQ ER QL+ +N
Sbjct: 331 GEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLKKQN 386
Query: 1050 MLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHL 1109
MLL+QQLDDA KA++QEK IQ + + +NLQAE K L L+E NK L++E NH
Sbjct: 387 MLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHS 446
Query: 1110 KERMDQCEKEKAGRKIDL 1127
KE+ Q EKEKA R++ +
Sbjct: 447 KEKECQYEKEKAEREVSI 464
Score = 55.5 bits (132), Expect = 4e-07
Identities = 88/409 (21%), Positives = 171/409 (41%), Gaps = 66/409 (16%)
Query: 428 KKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTS 487
KK RN E + +++E L++T+ + + +LK L + +S++ S
Sbjct: 103 KKRRNVEELHQKVREK----LRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVS 158
Query: 488 EVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLH--KDVEEEMEKHRSNSTELSGTL 545
E E+L + + ++E+ L + +K ++++ KD E KH L
Sbjct: 159 ETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALK--- 215
Query: 546 TDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIAS 605
+G T+ + Q+ ++E +++++ + + +E +E+ S
Sbjct: 216 RNGETLAKTIACYSGQLAA------------LTDENTTLRSKLEKQRESRQRLE-TEMQS 262
Query: 606 EDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQD-----TFCLCEHLLKLKNNHCDQLT 660
C L+ + R ++ S S R Q+ T C HL + N+H L+
Sbjct: 263 YHCRLNAA------------RCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILS 310
Query: 661 VKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYN 720
++L + E+ VL+ EL T + + L + EL KQ+ + ++ + +Y
Sbjct: 311 LQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSEL-------KQKQSQMKDIEKMYK 363
Query: 721 KDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLD------LVVQERNDAQKQ 774
+ E+C + E QLK L ++L RN D L +Q R DA+ Q
Sbjct: 364 SGYNTM----EKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQ 419
Query: 775 ----------LSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQK 813
L E+D ++L +++ SK+KE + ++K E+S + K
Sbjct: 420 NLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVSIKKNK 468
Score = 40.8 bits (94), Expect = 0.009
Identities = 61/340 (17%), Positives = 136/340 (40%), Gaps = 32/340 (9%)
Query: 952 DKMKVDMSGLQAKNEILSEKLSNAES-------KINSLQIQLHNTRDALGRESLILERVQ 1004
++++V + L+ K +L +++S E +I L+ +L + R A+ +E V+
Sbjct: 50 EQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVE 109
Query: 1005 RDLSQTQCQKKETEQMYQIEQSKLK--KYIAKQESVEERLSQLQSENMLLRQQLDDA-HK 1061
+ + + + TE+ Y+IE K K K VE + S + + +D H+
Sbjct: 110 ELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHE 169
Query: 1062 KANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKA 1121
Q++ + D +NL+ + K ++ K+++L E + + +
Sbjct: 170 NRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYS 229
Query: 1122 GRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNL 1181
G+ LT+ T+ S+ + L+ + + + +C+ Q + + QE
Sbjct: 230 GQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQE---- 285
Query: 1182 KSYMERNMLERGKAEWHKLLIEERARKEIEEKLNE--AILTLQKQAAVSHEQLVQLREDN 1239
+ +G + + ++E LN IL+LQ A S ++++
Sbjct: 286 -------LAFQGTVD---------KCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHY 329
Query: 1240 TTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKEL 1279
T + L + ++SE+ + ++ D K Y +
Sbjct: 330 TGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTM 369
>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 281 bits (720), Expect = 2e-75
Identities = 246/870 (28%), Positives = 421/870 (48%), Gaps = 169/870 (19%)
Query: 610 LSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENM 669
L ++VY L E+L + + +L + +T L + + + LK N+
Sbjct: 245 LHYAVYNKGTSLAERLLSHHANIEALNKEGNT----PLLFAINSRRQHMVEFLLKNQANI 300
Query: 670 VSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIK 729
+V K+T L L +Q L + L Q+N + DM + + +E +
Sbjct: 301 HAV-----DNFKRTALILAVQH-----NLSSIVTLLLQQNIRISSQDM-FGQTAEDYAL- 348
Query: 730 EEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERN--DAQKQLSEEQDARILQDQ 787
C + +QQ+ + +++K N ++ N +++ E + ++ ++
Sbjct: 349 ---CSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEE 405
Query: 788 ILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEK 847
KQ+ L+ + K + S + K+KD + + ML+++IA+L+ E+ IKN + +KEK
Sbjct: 406 ----KQERLQRSENKQPQD-SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 460
Query: 848 KYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQE 907
KY ++I+++ E N N +K ++LNE+ +T+T+ +YS QLN+L AEN LNSELE K N+E
Sbjct: 461 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKE 520
Query: 908 RLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEI 967
RLE E+ES LA A+ + ++ +DL+L R + V H+KM ++S L KNE+
Sbjct: 521 RLEAEVESLHSSLATAINEYNEIVERKDLELVLWRA--DDVSRHEKMGSNISQLTDKNEL 578
Query: 968 LSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSK 1027
L+E++ A K N+L+ +L TRDAL ++L L VQ DL Q Q + KE +QM+ ++K
Sbjct: 579 LTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAK 638
Query: 1028 LKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAE 1087
+ I KQ S+EER+ Q + EN+LL +QL+DA K+ +++E + +D + ++L
Sbjct: 639 ESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDL--- 695
Query: 1088 SEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV------------- 1134
L+E+NKELM EYN+LKE++ QCEKEKA R++ + E QE +
Sbjct: 696 -------LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESP 748
Query: 1135 ---PSRCLHLDAENEVLQLQQTLFSMK------------------AIQKQCETLQKNKKQ 1173
S C H++ NE ++ LF ++ + + ++K ++
Sbjct: 749 LEGTSHC-HINL-NETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRE 806
Query: 1174 LKQEVVNLKSYMER--NMLERGKAE---WHKLLIEERAR-----KEIEEKLNEAI----- 1218
L++E K +E NML E H L ++ + K++++K N+ +
Sbjct: 807 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEA 866
Query: 1219 -----LTLQKQAAVSHEQLVQLR----------------EDNTTSIKTQMELTIKDL--- 1254
+ L K V H++L+ +R E+ ++KT ME + +L
Sbjct: 867 VSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKL 926
Query: 1255 -----------ESEISRIK----TSQADFNK---------TELERYKELYLEEV------ 1284
EI +++ QA++ K T + KEL L++V
Sbjct: 927 QEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSK 986
Query: 1285 -----------------------KVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSLF 1321
K S+S +L ++++ IA +ST+L EK+ R +
Sbjct: 987 MKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQ--RMKYFL 1044
Query: 1322 TAYATRPVLESPCVGNLNDSEGLNRKHIPR 1351
+ TRP E PCV NLN E LNRK+IP+
Sbjct: 1045 STLPTRPEPELPCVENLNSIE-LNRKYIPK 1073
Score = 59.7 bits (143), Expect = 2e-08
Identities = 116/631 (18%), Positives = 267/631 (42%), Gaps = 69/631 (10%)
Query: 452 KNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTSEVYLHEELQQ--DMQKF------- 502
+N NQ + + N K K + + +L S+ E E +Q D Q +
Sbjct: 372 RNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAM 431
Query: 503 ------KNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDD 556
K ++ L+EE A+K + ++ K +E++ + TE++
Sbjct: 432 YGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK----SITEINANFEKSVR------ 481
Query: 557 GLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYE 616
LN+++ K + + + E + +++ E + +E +E+ S L+ ++ E
Sbjct: 482 -LNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLE-AEVESLHSSLATAINE 539
Query: 617 -NFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQN 675
N ++ + L + + + R + + ++ +L + + + LT ++ + + L+
Sbjct: 540 YNEIVERKDLELVLWRADDVSRHEK---MGSNISQLTDKN-ELLTEQVHKARVKFNTLKG 595
Query: 676 ELSETKKTKLQLELQKIEWEKELYDLRLALKQ-----ENEEKRNADMLYNKDSEQLRIKE 730
+L ET+ + L + +L + +K+ N E + + + ++S + RI++
Sbjct: 596 KLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQ 655
Query: 731 EECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERND----AQKQLSEEQDARILQD 786
+E ++ L R +++ R +N ++V+ D ++ L EE++ ++++
Sbjct: 656 QELENLL---------LERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE 706
Query: 787 QILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIK-NQNKQK 845
K+K L+ ++K E+ R +E+ + H E L I N+
Sbjct: 707 YNYL-KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTS 765
Query: 846 EKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQN 905
+KK F+ +EK++ +K+ +L ++L Y+ + + +N+ L E K+
Sbjct: 766 KKKLFQVEIQPEEKHEEFRKLFEL------ISLLNYTA--DQIRKKNRELEEEATGYKKC 817
Query: 906 QERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEW---VRLHDKMKVDMSGLQ 962
E + ++ + D + Q D+ F++ +Q++ V + + + L
Sbjct: 818 LEMTINMLNAFANEDFSCHGDLNTDQLKMDIL--FKKLKQKFNDLVAEKEAVSSECVNLA 875
Query: 963 AKNEILSEKL---SNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQ 1019
NE+L ++L N + K L+ + + +E+ +L + Q K E ++
Sbjct: 876 KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDE 935
Query: 1020 MYQIEQSKLKK-YIAKQESVEERLSQLQSEN 1049
E KL++ ++ KQ E++L QL +N
Sbjct: 936 RAVQEIEKLEEIHLQKQAEYEKQLEQLNKDN 966
Score = 38.9 bits (89), Expect = 0.036
Identities = 18/36 (50%), Positives = 26/36 (72%)
Query: 211 SQLPENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246
+ L + KE +AE + ++ SEE+QERL+ ENKQPQ
Sbjct: 384 ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQ 419
Score = 34.7 bits (78), Expect = 0.67
Identities = 18/42 (42%), Positives = 24/42 (57%)
Query: 72 PQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRK 113
P +D+R +L ++HRAA GD VE L +D RDRK
Sbjct: 133 PGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRK 174
>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 281 bits (720), Expect = 2e-75
Identities = 246/870 (28%), Positives = 421/870 (48%), Gaps = 169/870 (19%)
Query: 610 LSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENM 669
L ++VY L E+L + + +L + +T L + + + LK N+
Sbjct: 245 LHYAVYNKGTSLAERLLSHHANIEALNKEGNT----PLLFAINSRRQHMVEFLLKNQANI 300
Query: 670 VSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIK 729
+V K+T L L +Q L + L Q+N + DM + + +E +
Sbjct: 301 HAV-----DNFKRTALILAVQH-----NLSSIVTLLLQQNIRISSQDM-FGQTAEDYAL- 348
Query: 730 EEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERN--DAQKQLSEEQDARILQDQ 787
C + +QQ+ + +++K N ++ N +++ E + ++ ++
Sbjct: 349 ---CSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEE 405
Query: 788 ILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEK 847
KQ+ L+ + K + S + K+KD + + ML+++IA+L+ E+ IKN + +KEK
Sbjct: 406 ----KQERLQRSENKQPQD-SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 460
Query: 848 KYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQE 907
KY ++I+++ E N N +K ++LNE+ +T+T+ +YS QLN+L AEN LNSELE K N+E
Sbjct: 461 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKE 520
Query: 908 RLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEI 967
RLE E+ES LA A+ + ++ +DL+L R + V H+KM ++S L KNE+
Sbjct: 521 RLEAEVESLHSSLATAINEYNEIVERKDLELVLWRA--DDVSRHEKMGSNISQLTDKNEL 578
Query: 968 LSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSK 1027
L+E++ A K N+L+ +L TRDAL ++L L VQ DL Q Q + KE +QM+ ++K
Sbjct: 579 LTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAK 638
Query: 1028 LKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAE 1087
+ I KQ S+EER+ Q + EN+LL +QL+DA K+ +++E + +D + ++L
Sbjct: 639 ESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDL--- 695
Query: 1088 SEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV------------- 1134
L+E+NKELM EYN+LKE++ QCEKEKA R++ + E QE +
Sbjct: 696 -------LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESP 748
Query: 1135 ---PSRCLHLDAENEVLQLQQTLFSMK------------------AIQKQCETLQKNKKQ 1173
S C H++ NE ++ LF ++ + + ++K ++
Sbjct: 749 LEGTSHC-HINL-NETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRE 806
Query: 1174 LKQEVVNLKSYMER--NMLERGKAE---WHKLLIEERAR-----KEIEEKLNEAI----- 1218
L++E K +E NML E H L ++ + K++++K N+ +
Sbjct: 807 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEA 866
Query: 1219 -----LTLQKQAAVSHEQLVQLR----------------EDNTTSIKTQMELTIKDL--- 1254
+ L K V H++L+ +R E+ ++KT ME + +L
Sbjct: 867 VSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKL 926
Query: 1255 -----------ESEISRIK----TSQADFNK---------TELERYKELYLEEV------ 1284
EI +++ QA++ K T + KEL L++V
Sbjct: 927 QEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSK 986
Query: 1285 -----------------------KVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSLF 1321
K S+S +L ++++ IA +ST+L EK+ R +
Sbjct: 987 MKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQ--RMKYFL 1044
Query: 1322 TAYATRPVLESPCVGNLNDSEGLNRKHIPR 1351
+ TRP E PCV NLN E LNRK+IP+
Sbjct: 1045 STLPTRPEPELPCVENLNSIE-LNRKYIPK 1073
Score = 59.7 bits (143), Expect = 2e-08
Identities = 116/631 (18%), Positives = 267/631 (42%), Gaps = 69/631 (10%)
Query: 452 KNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTSEVYLHEELQQ--DMQKF------- 502
+N NQ + + N K K + + +L S+ E E +Q D Q +
Sbjct: 372 RNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAM 431
Query: 503 ------KNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDD 556
K ++ L+EE A+K + ++ K +E++ + TE++
Sbjct: 432 YGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK----SITEINANFEKSVR------ 481
Query: 557 GLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYE 616
LN+++ K + + + E + +++ E + +E +E+ S L+ ++ E
Sbjct: 482 -LNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLE-AEVESLHSSLATAINE 539
Query: 617 -NFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQN 675
N ++ + L + + + R + + ++ +L + + + LT ++ + + L+
Sbjct: 540 YNEIVERKDLELVLWRADDVSRHEK---MGSNISQLTDKN-ELLTEQVHKARVKFNTLKG 595
Query: 676 ELSETKKTKLQLELQKIEWEKELYDLRLALKQ-----ENEEKRNADMLYNKDSEQLRIKE 730
+L ET+ + L + +L + +K+ N E + + + ++S + RI++
Sbjct: 596 KLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQ 655
Query: 731 EECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERND----AQKQLSEEQDARILQD 786
+E ++ L R +++ R +N ++V+ D ++ L EE++ ++++
Sbjct: 656 QELENLL---------LERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE 706
Query: 787 QILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIK-NQNKQK 845
K+K L+ ++K E+ R +E+ + H E L I N+
Sbjct: 707 YNYL-KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTS 765
Query: 846 EKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQN 905
+KK F+ +EK++ +K+ +L ++L Y+ + + +N+ L E K+
Sbjct: 766 KKKLFQVEIQPEEKHEEFRKLFEL------ISLLNYTA--DQIRKKNRELEEEATGYKKC 817
Query: 906 QERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEW---VRLHDKMKVDMSGLQ 962
E + ++ + D + Q D+ F++ +Q++ V + + + L
Sbjct: 818 LEMTINMLNAFANEDFSCHGDLNTDQLKMDIL--FKKLKQKFNDLVAEKEAVSSECVNLA 875
Query: 963 AKNEILSEKL---SNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQ 1019
NE+L ++L N + K L+ + + +E+ +L + Q K E ++
Sbjct: 876 KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDE 935
Query: 1020 MYQIEQSKLKK-YIAKQESVEERLSQLQSEN 1049
E KL++ ++ KQ E++L QL +N
Sbjct: 936 RAVQEIEKLEEIHLQKQAEYEKQLEQLNKDN 966
Score = 38.9 bits (89), Expect = 0.036
Identities = 18/36 (50%), Positives = 26/36 (72%)
Query: 211 SQLPENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246
+ L + KE +AE + ++ SEE+QERL+ ENKQPQ
Sbjct: 384 ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQ 419
Score = 34.7 bits (78), Expect = 0.67
Identities = 18/42 (42%), Positives = 24/42 (57%)
Query: 72 PQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRK 113
P +D+R +L ++HRAA GD VE L +D RDRK
Sbjct: 133 PGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRK 174
>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1002
Score = 280 bits (715), Expect = 9e-75
Identities = 246/870 (28%), Positives = 420/870 (48%), Gaps = 169/870 (19%)
Query: 610 LSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENM 669
L ++VY L E+L + + +L + +T L + + + LK N+
Sbjct: 138 LHYAVYNKGTSLAERLLSHHANIEALNKEGNT----PLLFAINSRRQHMVEFLLKNQANI 193
Query: 670 VSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIK 729
+V K+T L L +Q L + L Q+N + DM + + +E +
Sbjct: 194 HAV-----DNFKRTALILAVQH-----NLSSIVTLLLQQNIRISSQDM-FGQTAEDYAL- 241
Query: 730 EEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERN--DAQKQLSEEQDARILQDQ 787
C + +QQ+ + +++K N ++ N +++ E + ++ ++
Sbjct: 242 ---CSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEE 298
Query: 788 ILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEK 847
KQ+ L+ + K + S + K+KD + + ML+++IA+L+ E+ IKN + +KEK
Sbjct: 299 ----KQERLQRSENKQPQD-SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 353
Query: 848 KYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQE 907
KY ++I+++ E N N +K ++LNE+ +T+T+ +YS QLN+L AEN LNSELE K N+E
Sbjct: 354 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKE 413
Query: 908 RLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEI 967
RLE E+ES LA A+ + ++ +DL+L R + V H+KM ++S L KNE+
Sbjct: 414 RLEAEVESLHSSLATAINEYNEIVERKDLELVLWRA--DDVSRHEKMGSNISQLTDKNEL 471
Query: 968 LSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSK 1027
L+E++ A K N+L+ +L TRDAL ++L L VQ DL Q Q + KE +QM+ ++K
Sbjct: 472 LTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAK 531
Query: 1028 LKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAE 1087
+ I KQ S+EER+ Q + EN+LL +QL+DA K+ +++E + +D + ++L
Sbjct: 532 ESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDL--- 588
Query: 1088 SEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV------------- 1134
L+E+NKELM EYN+LKE++ QCEKEKA R++ + E QE +
Sbjct: 589 -------LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESP 641
Query: 1135 ---PSRCLHLDAENEVLQLQQTLFSMK------------------AIQKQCETLQKNKKQ 1173
S C H++ NE ++ LF ++ + + ++K ++
Sbjct: 642 LEGTSHC-HINL-NETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRE 699
Query: 1174 LKQEVVNLKSYMER--NMLERGKAE---WHKLLIEERAR-----KEIEEKLNEAI----- 1218
L++E K +E NML E H L ++ + K++++K N+ +
Sbjct: 700 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEA 759
Query: 1219 -----LTLQKQAAVSHEQLVQLR----------------EDNTTSIKTQMELTIKDL--- 1254
+ L K V H++L+ +R E+ ++KT ME + +L
Sbjct: 760 VSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKL 819
Query: 1255 -----------ESEISRIK----TSQADFNK---------TELERYKELYLEEV------ 1284
EI +++ QA++ K T + KEL L++V
Sbjct: 820 QEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSK 879
Query: 1285 -----------------------KVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSLF 1321
K S+S +L ++++ IA +ST+L +EKE R
Sbjct: 880 MKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFMEKE--RMEYFL 937
Query: 1322 TAYATRPVLESPCVGNLNDSEGLNRKHIPR 1351
+ RP E PCV NLN E LNRK+IP+
Sbjct: 938 STLPMRPDPELPCVENLNSIE-LNRKYIPK 966
Score = 60.1 bits (144), Expect = 1e-08
Identities = 128/706 (18%), Positives = 294/706 (41%), Gaps = 79/706 (11%)
Query: 452 KNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTSEVYLHEELQQ--DMQKF------- 502
+N NQ + + N K K + + +L S+ E E +Q D Q +
Sbjct: 265 RNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAM 324
Query: 503 ------KNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDD 556
K ++ L+EE A+K + ++ K +E++ + TE++
Sbjct: 325 YGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK----SITEINANFEKSVR------ 374
Query: 557 GLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYE 616
LN+++ K + + + E + +++ E + +E +E+ S L+ ++ E
Sbjct: 375 -LNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLE-AEVESLHSSLATAINE 432
Query: 617 -NFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQN 675
N ++ + L + + + R + + ++ +L + + + LT ++ + + L+
Sbjct: 433 YNEIVERKDLELVLWRADDVSRHEK---MGSNISQLTDKN-ELLTEQVHKARVKFNTLKG 488
Query: 676 ELSETKKTKLQLELQKIEWEKELYDLRLALKQ-----ENEEKRNADMLYNKDSEQLRIKE 730
+L ET+ + L + +L + +K+ N E + + + ++S + RI++
Sbjct: 489 KLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQ 548
Query: 731 EECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERND----AQKQLSEEQDARILQD 786
+E ++ L R +++ R +N ++V+ D ++ L EE++ ++++
Sbjct: 549 QELENLL---------LERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE 599
Query: 787 QILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIK-NQNKQK 845
K+K L+ ++K E+ R +E+ + H E L I N+
Sbjct: 600 YNYL-KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTS 658
Query: 846 EKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQN 905
+KK F+ +EK++ +K+ +L ++L Y+ + + +N+ L E K+
Sbjct: 659 KKKLFQVEIQPEEKHEEFRKLFEL------ISLLNYTA--DQIRKKNRELEEEATGYKKC 710
Query: 906 QERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEW---VRLHDKMKVDMSGLQ 962
E + ++ + D + Q D+ F++ +Q++ V + + + L
Sbjct: 711 LEMTINMLNAFANEDFSCHGDLNTDQLKMDIL--FKKLKQKFNDLVAEKEAVSSECVNLA 768
Query: 963 AKNEILSEKL---SNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQ 1019
NE+L ++L N + K L+ + + +E+ +L + Q K E ++
Sbjct: 769 KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDE 828
Query: 1020 MYQIEQSKLKK-YIAKQESVEERLSQLQSENM-------LLRQQLDDAHKKANSQEKTSS 1071
E KL++ ++ KQ E++L QL +N L + ++ K + + +
Sbjct: 829 RAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVT 888
Query: 1072 TIQDQFHSA---AKNLQAESEKQILSLQEKNKELMDEYNHLKERMD 1114
T ++F A A K+++ +K + + KERM+
Sbjct: 889 TELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFMEKERME 934
Score = 38.9 bits (89), Expect = 0.036
Identities = 18/36 (50%), Positives = 26/36 (72%)
Query: 211 SQLPENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246
+ L + KE +AE + ++ SEE+QERL+ ENKQPQ
Sbjct: 277 ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQ 312
Score = 34.7 bits (78), Expect = 0.67
Identities = 18/42 (42%), Positives = 24/42 (57%)
Query: 72 PQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRK 113
P +D+R +L ++HRAA GD VE L +D RDRK
Sbjct: 26 PGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRK 67
>gi|51972186 coiled-coil domain containing 144 family, N-terminal
like [Homo sapiens]
Length = 221
Score = 278 bits (712), Expect = 2e-74
Identities = 131/138 (94%), Positives = 132/138 (95%)
Query: 1 MASWGGEKRGGAEGSPKPAVYATRKTPSVGSQGDQWYLGYPGDQWSSGFPYSWWKNSVGS 60
MASWGGEKRGGA GSPKPAVYATRKTPSVGSQ DQWYL YPGDQWS GF YSWWKNSVGS
Sbjct: 1 MASWGGEKRGGAGGSPKPAVYATRKTPSVGSQEDQWYLDYPGDQWSLGFSYSWWKNSVGS 60
Query: 61 ESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRKKSIQQLV 120
ESKHGEGALDQ QHDVRLEDLGELHRAARSGDVPGVEH+LAPGDTGVDKRDRKKSIQQLV
Sbjct: 61 ESKHGEGALDQLQHDVRLEDLGELHRAARSGDVPGVEHVLAPGDTGVDKRDRKKSIQQLV 120
Query: 121 PEYKEKQTPESLPQNNNP 138
PEYKEKQTPESLPQNNNP
Sbjct: 121 PEYKEKQTPESLPQNNNP 138
>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
Length = 1392
Score = 278 bits (710), Expect = 4e-74
Identities = 211/655 (32%), Positives = 333/655 (50%), Gaps = 90/655 (13%)
Query: 497 QDMQKFKNE-VNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDD 555
+D + FK E V+++E F K + + + E + N T G T D
Sbjct: 788 KDRETFKAEDVSSVESTFSLFGKPTTENSQSTKVEED---FNLTTKEGATKTVTGQQERD 844
Query: 556 DGLNQQIPRKENG-----EHDRPADKTSNEKNEVKN-------QIYPEADFADSMEPSEI 603
G+ ++ P+ + E R D S +E+ + + PEA + ++ +
Sbjct: 845 IGIIERAPQDQTNKMPTSELGRKEDTKSTSDSEIISVSDTQNYECLPEATYQKEIKTTNG 904
Query: 604 ASEDCELSHSVYE---NFMLLIEQLRMEYK-------DSASLPRIQDTFCLCEHLLKLKN 653
E+ S +E + +E+K DS +L +I D CE +LK
Sbjct: 905 KIEESPEKPSHFEPATEMQNSVPNKGLEWKNKQTLRADSTTLSKILDALPSCERGRELKK 964
Query: 654 NHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKR 713
++C+Q+T K+ E ++ K LQ EL
Sbjct: 965 DNCEQITAKM------------EQTKNKFCVLQKEL------------------------ 988
Query: 714 NADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQK 773
SE IK + + + +Q+L ++R + + R N+D +++E+ ++
Sbjct: 989 ---------SEAKEIKSQLENQKAKWEQEL-CSVRLTLNQEEEKRRNVD-ILKEKIRPEE 1037
Query: 774 QLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRL 833
QL ++ + + +Q L + EL+ +N ++SH H+ E DLFHE+CML++EIA+L+L
Sbjct: 1038 QLRKKLEVKQQLEQTLRIQDIELKSVTSNLN-QVSHTHESENDLFHENCMLKKEIAMLKL 1096
Query: 834 EIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENK 893
E+ T+K+Q++ KE KYFEDI+ ++EKN LQ +KL ++T+T+ QY QL LTAEN
Sbjct: 1097 EVATLKHQHQVKENKYFEDIKILQEKNAELQMTLKLKQKTVTKRASQYREQLKVLTAENT 1156
Query: 894 ILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTAR-DLKLDFQRTRQEWVRLHD 952
+L S+L+ KQ++E LE E+ES+ RLA+A++D DQS T+R + +L F L
Sbjct: 1157 MLTSKLKE-KQDKEILETEIESHHPRLASALQDHDQSVTSRKNQELAFHSAGD--APLQG 1213
Query: 953 KMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQC 1012
M VD+S NE+L + L A+ K S +I L+ D L +L+ E QRD +TQC
Sbjct: 1214 IMNVDVSNTIYNNEVLHQPLYEAQRKSKSPKINLNYAGDDLRENALVSEHAQRDRCETQC 1273
Query: 1013 QKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSST 1072
Q K+ E MYQ EQ + K+ +QES+E++L QL+S+N LRQQL AHKK N + T
Sbjct: 1274 QMKKAEHMYQNEQDNVDKHTEQQESLEQKLFQLESKNRWLRQQLVYAHKKVNKSKVTI-- 1331
Query: 1073 IQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDL 1127
N+Q K L EKN+E+ + NHLKER+DQ EKEKA R++ +
Sbjct: 1332 ----------NIQFPEMKMQRHLNEKNEEVFNYGNHLKERIDQYEKEKAEREVSI 1376
Score = 38.5 bits (88), Expect = 0.047
Identities = 127/643 (19%), Positives = 240/643 (37%), Gaps = 108/643 (16%)
Query: 178 TKELGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDSELTSEEEQERL 237
TKE +T +++ D G++ + D + + S+L KE ++ DSE+ S + +
Sbjct: 829 TKEGATKTVTGQQERDIGIIERAPQDQTNKMPTSEL-GRKEDTKSTSDSEIISVSDTQNY 887
Query: 238 KGCENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMW--IEQGKLEWKNQLKLVI 295
+ C P+ T Q+ + E+ P P H + + EM + LEWKN K +
Sbjct: 888 E-C---LPEATYQKEIKTTNGKIEESPEKP--SHFEPATEMQNSVPNKGLEWKN--KQTL 939
Query: 296 NELKQRFGEIYEKYKIPACPEEEPL-LDNSTRGT------------------DVKDIPFN 336
+I + +P+C L DN + T + K+I
Sbjct: 940 RADSTTLSKILD--ALPSCERGRELKKDNCEQITAKMEQTKNKFCVLQKELSEAKEIKSQ 997
Query: 337 LTNNIPGCEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQSSSKFHL 396
L N E+E S + +++ E + LK I P E Q +
Sbjct: 998 LENQKAKWEQELCS-VRLTLNQEEEKRRNVDILKEKIRP-EEQLRKKLEVKQQLEQTLRI 1055
Query: 397 HENKLDCDNDNKPGIGHIFSTDKN-FHNDASTKKARNPEVVMVEMKEDQEFDLQMTKNMN 455
+ +L N + H ++ + FH + KK E+ M+++ ++ K+ +
Sbjct: 1056 QDIELKSVTSNLNQVSHTHESENDLFHENCMLKK----EIAMLKL------EVATLKHQH 1105
Query: 456 QNSDSGSTNNYKSLKPKLENLSSLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLA 515
Q ++ + K L+ K L +T + + Q ++ K V T E L
Sbjct: 1106 QVKENKYFEDIKILQEKNAELQMTLKLKQKT----VTKRASQYREQLK--VLTAENTMLT 1159
Query: 516 LKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPAD 575
K ++ Q + +E E+E H PR + D
Sbjct: 1160 SKLKEKQDKEILETEIESHH---------------------------PRLASALQDHDQS 1192
Query: 576 KTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASL 635
TS + E+ +A M + ++S+++Y N +L Q E + +
Sbjct: 1193 VTSRKNQELAFHSAGDAPLQGIM--------NVDVSNTIYNNEVL--HQPLYEAQRKSKS 1242
Query: 636 PRIQDTFC---LCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKI 692
P+I + L E+ L ++ D+ + QM+ + QNE K Q E
Sbjct: 1243 PKINLNYAGDDLRENALVSEHAQRDRCETQC-QMKKAEHMYQNEQDNVDKHTEQQE---- 1297
Query: 693 EWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVK 752
E++L+ L + ++ A NK + I+ E +++ +L +
Sbjct: 1298 SLEQKLFQLESKNRWLRQQLVYAHKKVNKSKVTINIQFPE--------MKMQRHLNEKNE 1349
Query: 753 ELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKE 795
E+ N+L +ER D ++ E++ I + + ++ KE
Sbjct: 1350 EVFNYGNHL----KERIDQYEKEKAEREVSIKKYKYFSNFLKE 1388
Score = 37.0 bits (84), Expect = 0.14
Identities = 74/398 (18%), Positives = 156/398 (39%), Gaps = 29/398 (7%)
Query: 966 EILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQ 1025
E ++ K+ ++K LQ +L ++ + LE + Q C + T + Q E+
Sbjct: 968 EQITAKMEQTKNKFCVLQKELSEAKEIKSQ----LENQKAKWEQELCSVRLT--LNQEEE 1021
Query: 1026 SK-----LKKYIAKQESVEERLSQLQSENMLLRQQ---LDDAHKKANSQEKTSSTIQDQF 1077
+ LK+ I +E + ++L Q LR Q L N T + D F
Sbjct: 1022 KRRNVDILKEKIRPEEQLRKKLEVKQQLEQTLRIQDIELKSVTSNLNQVSHTHESENDLF 1081
Query: 1078 HSAAKNLQAESEKQILSLQE---KNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV 1134
H +N + E +L L+ K++ + E N E + +++ A ++ L Q+TV
Sbjct: 1082 H---ENCMLKKEIAMLKLEVATLKHQHQVKE-NKYFEDIKILQEKNAELQMTLKLKQKTV 1137
Query: 1135 PSRCLHLDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGK 1194
R + +VL + T+ + K +KQ + + + +++ L S ++ +
Sbjct: 1138 TKRASQYREQLKVLTAENTMLTSKLKEKQDKEILET--EIESHHPRLASALQDHDQSVTS 1195
Query: 1195 AEWHKLLIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDL 1254
+ +L ++ +N + V H+ L + + + S K + DL
Sbjct: 1196 RKNQELAFHSAGDAPLQGIMNVDVSNTIYNNEVLHQPLYEAQR-KSKSPKINLNYAGDDL 1254
Query: 1255 ESEISRIKTSQADFNKTELERYKELYLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQ 1314
+ +Q D +T+ + K ++ ++ + + + E + +L + +
Sbjct: 1255 RENALVSEHAQRDRCETQCQMKKAEHM-----YQNEQDNVDKHTEQQESLEQKLFQLESK 1309
Query: 1315 TRSRSLFTAYATRPVLESPCVGNLNDSEGLNRKHIPRK 1352
R YA + V +S N+ E ++H+ K
Sbjct: 1310 NRWLRQQLVYAHKKVNKSKVTINIQFPEMKMQRHLNEK 1347
>gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 276 bits (706), Expect = 1e-73
Identities = 186/481 (38%), Positives = 271/481 (56%), Gaps = 61/481 (12%)
Query: 662 KLKQMENMV----SVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADM 717
K++ EN+ S + L++ +K Q + KE +D R LKQENEEK N +M
Sbjct: 396 KIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHD-RCTLKQENEEKTNVNM 454
Query: 718 LYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSE 777
L+ K+ E+L KE KQ +
Sbjct: 455 LHKKNREELERKE------------------------------------------KQYKK 472
Query: 778 EQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDT 837
E +A+ L+ + + + K + AR N + H H++ KDL E+C+L+ +IA+LR EI T
Sbjct: 473 EVEAKQLEPTVQSLEMKP-KTARNTPNQDF-HNHEEVKDLMDENCILKTDIAILRQEICT 530
Query: 838 IKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNS 897
+KN N +KE KY +DI+ KE N L+K IKLNEE +T+T Y +LN+L AEN LNS
Sbjct: 531 MKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNS 590
Query: 898 ELENGKQNQERLEIEMESYRCRLAAAV-RDCDQSQTARDLKLDFQRTRQEWVRLHDKMKV 956
EL K+++++LE E+ESY+ RLAAA+ + + +T R+LKL +RT+ + KM
Sbjct: 591 ELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQD--ISEQVKMSS 648
Query: 957 DMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKE 1016
D+S ++ KN L+E+LS + K N+L+ + TRD L ++SL LE VQ DLSQTQ Q KE
Sbjct: 649 DISEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKE 708
Query: 1017 TEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQ 1076
++MYQ ++K+ K K VEER+ QLQ EN L QQL D H+K + +E + IQ
Sbjct: 709 MKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVIN-IQRG 767
Query: 1077 FHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPS 1136
F ES K+ L L+EKNK+LM+EY+HLKE + Q E++KA + + E + S
Sbjct: 768 F--------IESRKKDLMLEEKNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTS 819
Query: 1137 R 1137
R
Sbjct: 820 R 820
Score = 51.6 bits (122), Expect = 5e-06
Identities = 96/477 (20%), Positives = 188/477 (39%), Gaps = 75/477 (15%)
Query: 493 EELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVG 552
EE QQ ++ + + + E K E +QL +++ S + + LT +G
Sbjct: 369 EEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENI------CHSTFSAAADRLTQQRKIG 422
Query: 553 NDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIY----PEADFADSMEPSEIASEDC 608
QQ P+K EHDR K NE+ N ++ E + + E+ ++
Sbjct: 423 KT---YPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQL 479
Query: 609 ELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMEN 668
E + ++ L M+ K + + P QD F E + L + +C ++
Sbjct: 480 EPT----------VQSLEMKPKTARNTPN-QD-FHNHEEVKDLMDENC--------ILKT 519
Query: 669 MVSVLQNELSETKKTKLQLE---LQKIEWEKEL-YDLRLALKQENEEKRNADMLYNKDSE 724
+++L+ E+ K L+ E L+ I+ KE L +K E Y ++
Sbjct: 520 DIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELN 579
Query: 725 QLR----------IKEEECGKVVET-----KQQLKWNLRRLVKELRTVRNNLDLVVQERN 769
L+ +KE+E K +E + +L + + + ++T R NL L ++
Sbjct: 580 DLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTER-NLKLALERTQ 638
Query: 770 DAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIA 829
D +Q+ D ++D K + + +I K+K D + ++ +A
Sbjct: 639 DISEQVKMSSDISEIED-------KNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLA 691
Query: 830 LLRLEIDTIKNQNKQKE-KKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNL 888
L ++ D + Q + KE K+ ++ EA K+ ++ E I Q L
Sbjct: 692 LETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVE-------ERICQ-------L 737
Query: 889 TAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQ 945
EN L +L + Q ++ EI + R + + +D + + L ++ ++
Sbjct: 738 QRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKE 794
Score = 31.6 bits (70), Expect = 5.7
Identities = 15/32 (46%), Positives = 21/32 (65%)
Query: 215 ENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246
+N ++ AEQ + SEEEQ+R + E KQPQ
Sbjct: 353 KNVQTLRAEQALPVASEEEQQRRERSEKKQPQ 384
>gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 276 bits (706), Expect = 1e-73
Identities = 186/481 (38%), Positives = 271/481 (56%), Gaps = 61/481 (12%)
Query: 662 KLKQMENMV----SVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADM 717
K++ EN+ S + L++ +K Q + KE +D R LKQENEEK N +M
Sbjct: 396 KIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHD-RCTLKQENEEKTNVNM 454
Query: 718 LYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSE 777
L+ K+ E+L KE KQ +
Sbjct: 455 LHKKNREELERKE------------------------------------------KQYKK 472
Query: 778 EQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDT 837
E +A+ L+ + + + K + AR N + H H++ KDL E+C+L+ +IA+LR EI T
Sbjct: 473 EVEAKQLEPTVQSLEMKP-KTARNTPNQDF-HNHEEVKDLMDENCILKTDIAILRQEICT 530
Query: 838 IKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNS 897
+KN N +KE KY +DI+ KE N L+K IKLNEE +T+T Y +LN+L AEN LNS
Sbjct: 531 MKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNS 590
Query: 898 ELENGKQNQERLEIEMESYRCRLAAAV-RDCDQSQTARDLKLDFQRTRQEWVRLHDKMKV 956
EL K+++++LE E+ESY+ RLAAA+ + + +T R+LKL +RT+ + KM
Sbjct: 591 ELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQD--ISEQVKMSS 648
Query: 957 DMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKE 1016
D+S ++ KN L+E+LS + K N+L+ + TRD L ++SL LE VQ DLSQTQ Q KE
Sbjct: 649 DISEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKE 708
Query: 1017 TEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQ 1076
++MYQ ++K+ K K VEER+ QLQ EN L QQL D H+K + +E + IQ
Sbjct: 709 MKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVIN-IQRG 767
Query: 1077 FHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPS 1136
F ES K+ L L+EKNK+LM+EY+HLKE + Q E++KA + + E + S
Sbjct: 768 F--------IESRKKDLMLEEKNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTS 819
Query: 1137 R 1137
R
Sbjct: 820 R 820
Score = 51.6 bits (122), Expect = 5e-06
Identities = 96/477 (20%), Positives = 188/477 (39%), Gaps = 75/477 (15%)
Query: 493 EELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVG 552
EE QQ ++ + + + E K E +QL +++ S + + LT +G
Sbjct: 369 EEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENI------CHSTFSAAADRLTQQRKIG 422
Query: 553 NDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIY----PEADFADSMEPSEIASEDC 608
QQ P+K EHDR K NE+ N ++ E + + E+ ++
Sbjct: 423 KT---YPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQL 479
Query: 609 ELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMEN 668
E + ++ L M+ K + + P QD F E + L + +C ++
Sbjct: 480 EPT----------VQSLEMKPKTARNTPN-QD-FHNHEEVKDLMDENC--------ILKT 519
Query: 669 MVSVLQNELSETKKTKLQLE---LQKIEWEKEL-YDLRLALKQENEEKRNADMLYNKDSE 724
+++L+ E+ K L+ E L+ I+ KE L +K E Y ++
Sbjct: 520 DIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELN 579
Query: 725 QLR----------IKEEECGKVVET-----KQQLKWNLRRLVKELRTVRNNLDLVVQERN 769
L+ +KE+E K +E + +L + + + ++T R NL L ++
Sbjct: 580 DLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTER-NLKLALERTQ 638
Query: 770 DAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIA 829
D +Q+ D ++D K + + +I K+K D + ++ +A
Sbjct: 639 DISEQVKMSSDISEIED-------KNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLA 691
Query: 830 LLRLEIDTIKNQNKQKE-KKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNL 888
L ++ D + Q + KE K+ ++ EA K+ ++ E I Q L
Sbjct: 692 LETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVE-------ERICQ-------L 737
Query: 889 TAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQ 945
EN L +L + Q ++ EI + R + + +D + + L ++ ++
Sbjct: 738 QRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKE 794
Score = 31.6 bits (70), Expect = 5.7
Identities = 15/32 (46%), Positives = 21/32 (65%)
Query: 215 ENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246
+N ++ AEQ + SEEEQ+R + E KQPQ
Sbjct: 353 KNVQTLRAEQALPVASEEEQQRRERSEKKQPQ 384
>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
sapiens]
Length = 823
Score = 272 bits (696), Expect = 1e-72
Identities = 186/490 (37%), Positives = 273/490 (55%), Gaps = 67/490 (13%)
Query: 649 LKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQE 708
++L N CD + S L++ +K Q + KE +D R LKQE
Sbjct: 397 IQLSENICDSTS----------SAAAGRLTQQRKIGKTYPQQFPKKLKEEHD-RCTLKQE 445
Query: 709 NEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQER 768
NEEK N +MLY K+ E+L KE
Sbjct: 446 NEEKTNVNMLYKKNREELERKE-------------------------------------- 467
Query: 769 NDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEI 828
KQ +E +A+ L+ + + + K + AR N + H H++ K L E+C+L+ +I
Sbjct: 468 ----KQYKKEVEAKQLEPTVQSLEMKS-KTARNTPNWDF-HNHEEMKGLMDENCILKADI 521
Query: 829 ALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNL 888
A+LR EI T+KN N +KE KY +DI+ VKE N L+K IKLNEE +TET +Y +LN+L
Sbjct: 522 AILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDL 581
Query: 889 TAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQS-QTARDLKLDFQRTRQEW 947
AEN LN+EL K++++RLE ++ESY+ RLAAA+ +S +T R+LKL +RTR
Sbjct: 582 KAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRD-- 639
Query: 948 VRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDL 1007
V + +M +S ++A+NE L+E+LS + K N+L+ + TRD+L ++SL LE VQ DL
Sbjct: 640 VSVQVEMSSAISKVKAENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDL 699
Query: 1008 SQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQE 1067
SQTQ Q +E ++MYQ ++K+ K VEER+ LQ EN L QQLDD H+K + +E
Sbjct: 700 SQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKE 759
Query: 1068 KTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDL 1127
++ IQ F ES K+ L L+EK+K+LM+E +HLKE + Q E+EK + +
Sbjct: 760 IVTN-IQRGF--------IESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSI 810
Query: 1128 TEAQETVPSR 1137
E + SR
Sbjct: 811 KEDKYFQTSR 820
Score = 58.5 bits (140), Expect = 4e-08
Identities = 100/483 (20%), Positives = 199/483 (41%), Gaps = 84/483 (17%)
Query: 478 SLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSN 537
+LP S+ E + E +Q K N N K E +QL +++ + S
Sbjct: 363 ALPVASEEEQERHERSEKKQPQVKEGNNTN---------KSEKIQLSENICD------ST 407
Query: 538 STELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIY----PEAD 593
S+ +G LT +G QQ P+K EHDR K NE+ N +Y E +
Sbjct: 408 SSAAAGRLTQQRKIGKT---YPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELE 464
Query: 594 FADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPR-----------IQDTF 642
+ E+ ++ E + ++ L M+ K + + P + D
Sbjct: 465 RKEKQYKKEVEAKQLEPT----------VQSLEMKSKTARNTPNWDFHNHEEMKGLMDEN 514
Query: 643 CLCE-HLLKLKNNHC----DQLTVKLKQMENMVSVLQNELSETKKTKLQLEL---QKIEW 694
C+ + + L+ C D L + K ++++ V + + K KL E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRY 574
Query: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754
++EL D LK EN + NA++L K+S++ R++ + + + +L + + + +
Sbjct: 575 QQELND----LKAEN-TRLNAELLKEKESKK-RLEAD----IESYQSRLAAAISKHSESV 624
Query: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814
+T R NL L ++ D Q+ + I K + + + ++I K+
Sbjct: 625 KTER-NLKLALERTRDVSVQVE-------MSSAISKVKAENEFLTEQLSETQIKFNALKD 676
Query: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKE-KKYFEDIEAVKEKNDNLQKIIKLNEET 873
K D + ++ +AL ++ D + Q + +E K+ +++ EA K+N T
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEA------------KVNNST 724
Query: 874 LTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTA 933
++ ++ +L EN L +L++ Q ++ EI R + + +D + +
Sbjct: 725 GKWNCVE--ERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKS 782
Query: 934 RDL 936
+ L
Sbjct: 783 KKL 785
Score = 32.3 bits (72), Expect = 3.3
Identities = 16/32 (50%), Positives = 21/32 (65%)
Query: 215 ENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246
+N ++ AEQ + SEEEQER + E KQPQ
Sbjct: 353 KNVQTLRAEQALPVASEEEQERHERSEKKQPQ 384
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 271 bits (694), Expect = 3e-72
Identities = 239/873 (27%), Positives = 409/873 (46%), Gaps = 166/873 (19%)
Query: 610 LSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENM 669
L ++VY L E+L + + +L + +T L + + + LK N+
Sbjct: 237 LHYAVYNEGTSLAERLLSHHANIEALNKEGNT----PLLFAINSRRQHMVEFLLKNQANI 292
Query: 670 VSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIK 729
+V K+T L L +Q L + L Q+N + DM + + +E
Sbjct: 293 HAV-----DNFKRTALILAVQH-----NLSSIVTLLLQQNIHISSQDM-FGQTAEDYAF- 340
Query: 730 EEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERN----DAQKQLSEEQDARILQ 785
C + +QQ+ + +++K N ++ N +K+L + ++ +
Sbjct: 341 ---CCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAE 397
Query: 786 DQILTS---KQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQN 842
+ + KQ+ LE + K + S + K+KD + ML+ +IA+L+ E+ IKN +
Sbjct: 398 HNLKVASEEKQERLERSENKQPQD-SQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDS 456
Query: 843 KQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENG 902
+KEKKY ++I+++ E N N +K ++LNEE +T+ + QYS QLN+L AEN LNS+LE
Sbjct: 457 LRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKE 516
Query: 903 KQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQ 962
K N+ERLE E+ES LA A+ + ++ +DL+L R + V H+ M ++S L
Sbjct: 517 KHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRA--DDVSRHETMGSNISQLT 574
Query: 963 AKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQ 1022
KNE+L+E++ A K N+L+ +L TRDAL ++L LE VQ DL Q Q + KE +QM+
Sbjct: 575 DKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHP 634
Query: 1023 IEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAK 1082
++K + I KQ S EER+ Q + EN+LL +QL+DA K+ +++E + +D + +
Sbjct: 635 NGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKE 694
Query: 1083 NLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV-------- 1134
+L L+E+NKELM+EYN+LKE++ Q EKEKA R++ + E QE +
Sbjct: 695 DL----------LEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFS 744
Query: 1135 --------PSRC----------------LHLDAENEVLQLQQTLFSMKAIQKQCETLQKN 1170
S C + + E + + ++ + + + ++K
Sbjct: 745 MSESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKK 804
Query: 1171 KKQLKQEVVNLKSYMER--NMLERGKAE---WHKLLIEERARKEI--------------- 1210
++L++E K +E NML E H L ++ + +I
Sbjct: 805 NRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAE 864
Query: 1211 EEKLNEAILTLQKQAAVSHEQLV----------------QLREDNTTSIKTQMELTIKDL 1254
+E ++ + L K V H++L+ ++ E+ ++KT ME + +L
Sbjct: 865 KEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVEL 924
Query: 1255 --------------------------------ESEISRI-KTSQADFNKTEL-------- 1273
E ++ ++ K + A K EL
Sbjct: 925 GKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECK 984
Query: 1274 ---------------ERYKELYLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSR 1318
E YKE + +K S+S +++++++ IA +ST+L +EKE R
Sbjct: 985 FSKMKTAYEDVTTELEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKE--RME 1042
Query: 1319 SLFTAYATRPVLESPCVGNLNDSEGLNRKHIPR 1351
+ RP E PCV NLN E LNRK+IP+
Sbjct: 1043 YFLSTLPMRPDPELPCVENLNSIE-LNRKYIPK 1074
Score = 65.5 bits (158), Expect = 4e-10
Identities = 133/701 (18%), Positives = 290/701 (41%), Gaps = 109/701 (15%)
Query: 503 KNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGLNQQI 562
K ++ L+EE A+K + ++ K +E++ + TE++ LN+++
Sbjct: 439 KRDIAMLKEELYAIKNDSLRKEKKYIQEIK----SITEINANFEKSVR-------LNEEM 487
Query: 563 PRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYE-NFMLL 621
K+ ++ + + E + +++ E + +E +E+ S L+ ++ E N +L
Sbjct: 488 ITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLE-AEVESLHSNLATAINEYNEILE 546
Query: 622 IEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSET- 680
+ L + + + R + + ++ +L + + + LT ++ + + L+ +L ET
Sbjct: 547 RKDLELVLWRADDVSRHE---TMGSNISQLTDKN-ELLTEQVHKARVKFNTLKGKLRETR 602
Query: 681 ---KKTKLQLELQKIEWEKELYDLR-LALKQENEEKRNADMLYNKDSEQLRIKEEECGKV 736
++ L LE +++ ++ + ++ + N E + + + ++S + RI++ E +
Sbjct: 603 DALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENL 662
Query: 737 VETKQQLKWNLRRLVKELRTVRNNLDLVVQERND----AQKQLSEEQDARILQDQILTSK 792
+ L R +++ R +N ++V+ D ++ L EE++ ++ + K
Sbjct: 663 L---------LERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYL-K 712
Query: 793 QKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIK-NQNKQKEKKYFE 851
+K L+ ++K E+ R +E+ + H E L I ++ +KK F+
Sbjct: 713 EKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQ 772
Query: 852 DIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEI 911
+EK++ +K+ +L ++L Y+ + + +N+ L E K+ E + I
Sbjct: 773 VEIQPEEKHEEFRKVFEL------ISLLNYTA--DQIRKKNRELEEEATGYKKCLE-MTI 823
Query: 912 EMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEK 971
M + A C LK+D L K+K L A+ E +S K
Sbjct: 824 NMLN---AFANEDFSCHGDLNTDQLKMDI---------LFKKLKQKFDDLMAEKEAVSSK 871
Query: 972 LSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKY 1031
N L + L +E L + +VQ + + KK E+ ++ ++K
Sbjct: 872 CVN-----------LAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKD 920
Query: 1032 IAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQ 1091
+ + V+E S+L M ++L++ H + QAE EKQ
Sbjct: 921 MVELGKVQEYKSELDERAMQAIEKLEEIHLQK---------------------QAEYEKQ 959
Query: 1092 ILSLQEKN-KELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQL 1150
+ L + N L + LK+ + K K + TE +E
Sbjct: 960 LEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEDVTTELEE----------------YK 1003
Query: 1151 QQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLE 1191
+ ++KA E + K+ K++ V++ K +ME+ +E
Sbjct: 1004 EAFAVALKANSSMSEKITKSDKKI--AVISTKLFMEKERME 1042
Score = 48.9 bits (115), Expect = 3e-05
Identities = 126/663 (19%), Positives = 247/663 (37%), Gaps = 117/663 (17%)
Query: 210 QSQLPENKESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVL 269
+ +L + KE +AE + ++ SEE+QERL+ ENKQPQ +
Sbjct: 384 RKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQS------------------- 424
Query: 270 PHVQKSEEMWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKIPACPEEEPLLDNSTRGTD 329
+ +K +EM FG K I EE + N + +
Sbjct: 425 -YGKKKDEM-----------------------FGNFMLKRDIAMLKEELYAIKNDSLRKE 460
Query: 330 VKDIPFNLTNNIPGCEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQ 389
K I +E S ++ FE E + + Y + + +
Sbjct: 461 KKYI------------QEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENAR 508
Query: 390 SSSKFHLHENKLDCDNDNKPGIGHIFSTDKNFHNDASTKKARNPEVVMVEMKEDQEFDLQ 449
+SK ++ + + +T N +N+ +K + E+V+ +D
Sbjct: 509 LNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERK--DLELVLWR-ADDVSRHET 565
Query: 450 MTKNMNQNSDSGS--TNNYKSLKPKLENL-SSLPPDSDRTSEVYLH-EELQQDMQKFKNE 505
M N++Q +D T + K L L D E L E +Q D+++ ++
Sbjct: 566 MGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHR 625
Query: 506 VNTLEE---EFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVG-NDDDGLNQQ 561
+ +++ A + + + EE + + + L L D G N + +N
Sbjct: 626 IKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIH 685
Query: 562 IPRKENGEHDRPADKTS---NEKNEVKNQIYP---------------EADFADSMEPSEI 603
ENG+ D ++ NE N +K ++ + + D ++ +
Sbjct: 686 RDCLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSM 745
Query: 604 ASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKL 663
+ E + + N + ++ + F L+ L N DQ+ K
Sbjct: 746 SESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKN 805
Query: 664 KQME--------------NMVSVLQNE------LSETKKTKLQLELQKIEWEKELYDLRL 703
+++E NM++ NE T + K+ + +K+ K+ +D
Sbjct: 806 RELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKL---KQKFD--- 859
Query: 704 ALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDL 763
L E E + + KD+E L + GKV E ++L+ + + L +++ ++ +++
Sbjct: 860 DLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEK 919
Query: 764 VVQERNDAQKQLSEEQDARILQ-----DQILTSKQKELEMARKKMNSEISHRHQKEKDLF 818
+ E Q+ S E D R +Q ++I KQ E E +++N + + K+K+L
Sbjct: 920 DMVELGKVQEYKS-ELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKD-NTASLKKKELT 977
Query: 819 HED 821
+D
Sbjct: 978 LKD 980
Score = 31.6 bits (70), Expect = 5.7
Identities = 16/40 (40%), Positives = 23/40 (57%)
Query: 74 HDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRK 113
+ +R +L ++HRAA GD VEH L +D RD+K
Sbjct: 127 YHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVRDKK 166
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 271 bits (694), Expect = 3e-72
Identities = 239/873 (27%), Positives = 409/873 (46%), Gaps = 166/873 (19%)
Query: 610 LSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENM 669
L ++VY L E+L + + +L + +T L + + + LK N+
Sbjct: 266 LHYAVYNEGTSLAERLLSHHANIEALNKEGNT----PLLFAINSRRQHMVEFLLKNQANI 321
Query: 670 VSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIK 729
+V K+T L L +Q L + L Q+N + DM + + +E
Sbjct: 322 HAV-----DNFKRTALILAVQH-----NLSSIVTLLLQQNIHISSQDM-FGQTAEDYAF- 369
Query: 730 EEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERN----DAQKQLSEEQDARILQ 785
C + +QQ+ + +++K N ++ N +K+L + ++ +
Sbjct: 370 ---CCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAE 426
Query: 786 DQILTS---KQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQN 842
+ + KQ+ LE + K + S + K+KD + ML+ +IA+L+ E+ IKN +
Sbjct: 427 HNLKVASEEKQERLERSENKQPQD-SQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDS 485
Query: 843 KQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENG 902
+KEKKY ++I+++ E N N +K ++LNEE +T+ + QYS QLN+L AEN LNS+LE
Sbjct: 486 LRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKE 545
Query: 903 KQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQ 962
K N+ERLE E+ES LA A+ + ++ +DL+L R + V H+ M ++S L
Sbjct: 546 KHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRA--DDVSRHETMGSNISQLT 603
Query: 963 AKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQ 1022
KNE+L+E++ A K N+L+ +L TRDAL ++L LE VQ DL Q Q + KE +QM+
Sbjct: 604 DKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHP 663
Query: 1023 IEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAK 1082
++K + I KQ S EER+ Q + EN+LL +QL+DA K+ +++E + +D + +
Sbjct: 664 NGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKE 723
Query: 1083 NLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV-------- 1134
+L L+E+NKELM+EYN+LKE++ Q EKEKA R++ + E QE +
Sbjct: 724 DL----------LEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFS 773
Query: 1135 --------PSRC----------------LHLDAENEVLQLQQTLFSMKAIQKQCETLQKN 1170
S C + + E + + ++ + + + ++K
Sbjct: 774 MSESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKK 833
Query: 1171 KKQLKQEVVNLKSYMER--NMLERGKAE---WHKLLIEERARKEI--------------- 1210
++L++E K +E NML E H L ++ + +I
Sbjct: 834 NRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAE 893
Query: 1211 EEKLNEAILTLQKQAAVSHEQLV----------------QLREDNTTSIKTQMELTIKDL 1254
+E ++ + L K V H++L+ ++ E+ ++KT ME + +L
Sbjct: 894 KEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVEL 953
Query: 1255 --------------------------------ESEISRI-KTSQADFNKTEL-------- 1273
E ++ ++ K + A K EL
Sbjct: 954 GKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECK 1013
Query: 1274 ---------------ERYKELYLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSR 1318
E YKE + +K S+S +++++++ IA +ST+L +EKE R
Sbjct: 1014 FSKMKTAYEDVTTELEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKE--RME 1071
Query: 1319 SLFTAYATRPVLESPCVGNLNDSEGLNRKHIPR 1351
+ RP E PCV NLN E LNRK+IP+
Sbjct: 1072 YFLSTLPMRPDPELPCVENLNSIE-LNRKYIPK 1103
Score = 65.5 bits (158), Expect = 4e-10
Identities = 133/701 (18%), Positives = 290/701 (41%), Gaps = 109/701 (15%)
Query: 503 KNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGLNQQI 562
K ++ L+EE A+K + ++ K +E++ + TE++ LN+++
Sbjct: 468 KRDIAMLKEELYAIKNDSLRKEKKYIQEIK----SITEINANFEKSVR-------LNEEM 516
Query: 563 PRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYE-NFMLL 621
K+ ++ + + E + +++ E + +E +E+ S L+ ++ E N +L
Sbjct: 517 ITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLE-AEVESLHSNLATAINEYNEILE 575
Query: 622 IEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSET- 680
+ L + + + R + + ++ +L + + + LT ++ + + L+ +L ET
Sbjct: 576 RKDLELVLWRADDVSRHE---TMGSNISQLTDKN-ELLTEQVHKARVKFNTLKGKLRETR 631
Query: 681 ---KKTKLQLELQKIEWEKELYDLR-LALKQENEEKRNADMLYNKDSEQLRIKEEECGKV 736
++ L LE +++ ++ + ++ + N E + + + ++S + RI++ E +
Sbjct: 632 DALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENL 691
Query: 737 VETKQQLKWNLRRLVKELRTVRNNLDLVVQERND----AQKQLSEEQDARILQDQILTSK 792
+ L R +++ R +N ++V+ D ++ L EE++ ++ + K
Sbjct: 692 L---------LERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYL-K 741
Query: 793 QKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIK-NQNKQKEKKYFE 851
+K L+ ++K E+ R +E+ + H E L I ++ +KK F+
Sbjct: 742 EKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQ 801
Query: 852 DIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEI 911
+EK++ +K+ +L ++L Y+ + + +N+ L E K+ E + I
Sbjct: 802 VEIQPEEKHEEFRKVFEL------ISLLNYTA--DQIRKKNRELEEEATGYKKCLE-MTI 852
Query: 912 EMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEK 971
M + A C LK+D L K+K L A+ E +S K
Sbjct: 853 NMLN---AFANEDFSCHGDLNTDQLKMDI---------LFKKLKQKFDDLMAEKEAVSSK 900
Query: 972 LSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKY 1031
N L + L +E L + +VQ + + KK E+ ++ ++K
Sbjct: 901 CVN-----------LAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKD 949
Query: 1032 IAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQ 1091
+ + V+E S+L M ++L++ H + QAE EKQ
Sbjct: 950 MVELGKVQEYKSELDERAMQAIEKLEEIHLQK---------------------QAEYEKQ 988
Query: 1092 ILSLQEKN-KELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQL 1150
+ L + N L + LK+ + K K + TE +E
Sbjct: 989 LEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEDVTTELEE----------------YK 1032
Query: 1151 QQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLE 1191
+ ++KA E + K+ K++ V++ K +ME+ +E
Sbjct: 1033 EAFAVALKANSSMSEKITKSDKKI--AVISTKLFMEKERME 1071
Score = 48.9 bits (115), Expect = 3e-05
Identities = 126/663 (19%), Positives = 247/663 (37%), Gaps = 117/663 (17%)
Query: 210 QSQLPENKESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVL 269
+ +L + KE +AE + ++ SEE+QERL+ ENKQPQ +
Sbjct: 413 RKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQS------------------- 453
Query: 270 PHVQKSEEMWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKIPACPEEEPLLDNSTRGTD 329
+ +K +EM FG K I EE + N + +
Sbjct: 454 -YGKKKDEM-----------------------FGNFMLKRDIAMLKEELYAIKNDSLRKE 489
Query: 330 VKDIPFNLTNNIPGCEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQ 389
K I +E S ++ FE E + + Y + + +
Sbjct: 490 KKYI------------QEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENAR 537
Query: 390 SSSKFHLHENKLDCDNDNKPGIGHIFSTDKNFHNDASTKKARNPEVVMVEMKEDQEFDLQ 449
+SK ++ + + +T N +N+ +K + E+V+ +D
Sbjct: 538 LNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERK--DLELVLWR-ADDVSRHET 594
Query: 450 MTKNMNQNSDSGS--TNNYKSLKPKLENL-SSLPPDSDRTSEVYLH-EELQQDMQKFKNE 505
M N++Q +D T + K L L D E L E +Q D+++ ++
Sbjct: 595 MGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHR 654
Query: 506 VNTLEE---EFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVG-NDDDGLNQQ 561
+ +++ A + + + EE + + + L L D G N + +N
Sbjct: 655 IKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIH 714
Query: 562 IPRKENGEHDRPADKTS---NEKNEVKNQIYP---------------EADFADSMEPSEI 603
ENG+ D ++ NE N +K ++ + + D ++ +
Sbjct: 715 RDCLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSM 774
Query: 604 ASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKL 663
+ E + + N + ++ + F L+ L N DQ+ K
Sbjct: 775 SESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKN 834
Query: 664 KQME--------------NMVSVLQNE------LSETKKTKLQLELQKIEWEKELYDLRL 703
+++E NM++ NE T + K+ + +K+ K+ +D
Sbjct: 835 RELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKL---KQKFD--- 888
Query: 704 ALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDL 763
L E E + + KD+E L + GKV E ++L+ + + L +++ ++ +++
Sbjct: 889 DLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEK 948
Query: 764 VVQERNDAQKQLSEEQDARILQ-----DQILTSKQKELEMARKKMNSEISHRHQKEKDLF 818
+ E Q+ S E D R +Q ++I KQ E E +++N + + K+K+L
Sbjct: 949 DMVELGKVQEYKS-ELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKD-NTASLKKKELT 1006
Query: 819 HED 821
+D
Sbjct: 1007 LKD 1009
Score = 31.6 bits (70), Expect = 5.7
Identities = 16/40 (40%), Positives = 23/40 (57%)
Query: 74 HDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRK 113
+ +R +L ++HRAA GD VEH L +D RD+K
Sbjct: 156 YHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVRDKK 195
>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1139
Score = 271 bits (694), Expect = 3e-72
Identities = 239/873 (27%), Positives = 409/873 (46%), Gaps = 166/873 (19%)
Query: 610 LSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENM 669
L ++VY L E+L + + +L + +T L + + + LK N+
Sbjct: 266 LHYAVYNEGTSLAERLLSHHANIEALNKEGNT----PLLFAINSRRQHMVEFLLKNQANI 321
Query: 670 VSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIK 729
+V K+T L L +Q L + L Q+N + DM + + +E
Sbjct: 322 HAV-----DNFKRTALILAVQH-----NLSSIVTLLLQQNIHISSQDM-FGQTAEDYAF- 369
Query: 730 EEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERN----DAQKQLSEEQDARILQ 785
C + +QQ+ + +++K N ++ N +K+L + ++ +
Sbjct: 370 ---CCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAE 426
Query: 786 DQILTS---KQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQN 842
+ + KQ+ LE + K + S + K+KD + ML+ +IA+L+ E+ IKN +
Sbjct: 427 HNLKVASEEKQERLERSENKQPQD-SQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDS 485
Query: 843 KQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENG 902
+KEKKY ++I+++ E N N +K ++LNEE +T+ + QYS QLN+L AEN LNS+LE
Sbjct: 486 LRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKE 545
Query: 903 KQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQ 962
K N+ERLE E+ES LA A+ + ++ +DL+L R + V H+ M ++S L
Sbjct: 546 KHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRA--DDVSRHETMGSNISQLT 603
Query: 963 AKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQ 1022
KNE+L+E++ A K N+L+ +L TRDAL ++L LE VQ DL Q Q + KE +QM+
Sbjct: 604 DKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHP 663
Query: 1023 IEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAK 1082
++K + I KQ S EER+ Q + EN+LL +QL+DA K+ +++E + +D + +
Sbjct: 664 NGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKE 723
Query: 1083 NLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV-------- 1134
+L L+E+NKELM+EYN+LKE++ Q EKEKA R++ + E QE +
Sbjct: 724 DL----------LEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFS 773
Query: 1135 --------PSRC----------------LHLDAENEVLQLQQTLFSMKAIQKQCETLQKN 1170
S C + + E + + ++ + + + ++K
Sbjct: 774 MSESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKK 833
Query: 1171 KKQLKQEVVNLKSYMER--NMLERGKAE---WHKLLIEERARKEI--------------- 1210
++L++E K +E NML E H L ++ + +I
Sbjct: 834 NRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAE 893
Query: 1211 EEKLNEAILTLQKQAAVSHEQLV----------------QLREDNTTSIKTQMELTIKDL 1254
+E ++ + L K V H++L+ ++ E+ ++KT ME + +L
Sbjct: 894 KEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVEL 953
Query: 1255 --------------------------------ESEISRI-KTSQADFNKTEL-------- 1273
E ++ ++ K + A K EL
Sbjct: 954 GKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECK 1013
Query: 1274 ---------------ERYKELYLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSR 1318
E YKE + +K S+S +++++++ IA +ST+L +EKE R
Sbjct: 1014 FSKMKTAYEDVTTELEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKE--RME 1071
Query: 1319 SLFTAYATRPVLESPCVGNLNDSEGLNRKHIPR 1351
+ RP E PCV NLN E LNRK+IP+
Sbjct: 1072 YFLSTLPMRPDPELPCVENLNSIE-LNRKYIPK 1103
Score = 65.5 bits (158), Expect = 4e-10
Identities = 133/701 (18%), Positives = 290/701 (41%), Gaps = 109/701 (15%)
Query: 503 KNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGLNQQI 562
K ++ L+EE A+K + ++ K +E++ + TE++ LN+++
Sbjct: 468 KRDIAMLKEELYAIKNDSLRKEKKYIQEIK----SITEINANFEKSVR-------LNEEM 516
Query: 563 PRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYE-NFMLL 621
K+ ++ + + E + +++ E + +E +E+ S L+ ++ E N +L
Sbjct: 517 ITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLE-AEVESLHSNLATAINEYNEILE 575
Query: 622 IEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSET- 680
+ L + + + R + + ++ +L + + + LT ++ + + L+ +L ET
Sbjct: 576 RKDLELVLWRADDVSRHE---TMGSNISQLTDKN-ELLTEQVHKARVKFNTLKGKLRETR 631
Query: 681 ---KKTKLQLELQKIEWEKELYDLR-LALKQENEEKRNADMLYNKDSEQLRIKEEECGKV 736
++ L LE +++ ++ + ++ + N E + + + ++S + RI++ E +
Sbjct: 632 DALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENL 691
Query: 737 VETKQQLKWNLRRLVKELRTVRNNLDLVVQERND----AQKQLSEEQDARILQDQILTSK 792
+ L R +++ R +N ++V+ D ++ L EE++ ++ + K
Sbjct: 692 L---------LERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYL-K 741
Query: 793 QKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIK-NQNKQKEKKYFE 851
+K L+ ++K E+ R +E+ + H E L I ++ +KK F+
Sbjct: 742 EKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQ 801
Query: 852 DIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEI 911
+EK++ +K+ +L ++L Y+ + + +N+ L E K+ E + I
Sbjct: 802 VEIQPEEKHEEFRKVFEL------ISLLNYTA--DQIRKKNRELEEEATGYKKCLE-MTI 852
Query: 912 EMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEK 971
M + A C LK+D L K+K L A+ E +S K
Sbjct: 853 NMLN---AFANEDFSCHGDLNTDQLKMDI---------LFKKLKQKFDDLMAEKEAVSSK 900
Query: 972 LSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKY 1031
N L + L +E L + +VQ + + KK E+ ++ ++K
Sbjct: 901 CVN-----------LAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKD 949
Query: 1032 IAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQ 1091
+ + V+E S+L M ++L++ H + QAE EKQ
Sbjct: 950 MVELGKVQEYKSELDERAMQAIEKLEEIHLQK---------------------QAEYEKQ 988
Query: 1092 ILSLQEKN-KELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQL 1150
+ L + N L + LK+ + K K + TE +E
Sbjct: 989 LEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEDVTTELEE----------------YK 1032
Query: 1151 QQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLE 1191
+ ++KA E + K+ K++ V++ K +ME+ +E
Sbjct: 1033 EAFAVALKANSSMSEKITKSDKKI--AVISTKLFMEKERME 1071
Score = 48.9 bits (115), Expect = 3e-05
Identities = 126/663 (19%), Positives = 247/663 (37%), Gaps = 117/663 (17%)
Query: 210 QSQLPENKESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVL 269
+ +L + KE +AE + ++ SEE+QERL+ ENKQPQ +
Sbjct: 413 RKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQS------------------- 453
Query: 270 PHVQKSEEMWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKIPACPEEEPLLDNSTRGTD 329
+ +K +EM FG K I EE + N + +
Sbjct: 454 -YGKKKDEM-----------------------FGNFMLKRDIAMLKEELYAIKNDSLRKE 489
Query: 330 VKDIPFNLTNNIPGCEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQ 389
K I +E S ++ FE E + + Y + + +
Sbjct: 490 KKYI------------QEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENAR 537
Query: 390 SSSKFHLHENKLDCDNDNKPGIGHIFSTDKNFHNDASTKKARNPEVVMVEMKEDQEFDLQ 449
+SK ++ + + +T N +N+ +K + E+V+ +D
Sbjct: 538 LNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERK--DLELVLWR-ADDVSRHET 594
Query: 450 MTKNMNQNSDSGS--TNNYKSLKPKLENL-SSLPPDSDRTSEVYLH-EELQQDMQKFKNE 505
M N++Q +D T + K L L D E L E +Q D+++ ++
Sbjct: 595 MGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHR 654
Query: 506 VNTLEE---EFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVG-NDDDGLNQQ 561
+ +++ A + + + EE + + + L L D G N + +N
Sbjct: 655 IKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIH 714
Query: 562 IPRKENGEHDRPADKTS---NEKNEVKNQIYP---------------EADFADSMEPSEI 603
ENG+ D ++ NE N +K ++ + + D ++ +
Sbjct: 715 RDCLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSM 774
Query: 604 ASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKL 663
+ E + + N + ++ + F L+ L N DQ+ K
Sbjct: 775 SESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKN 834
Query: 664 KQME--------------NMVSVLQNE------LSETKKTKLQLELQKIEWEKELYDLRL 703
+++E NM++ NE T + K+ + +K+ K+ +D
Sbjct: 835 RELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKL---KQKFD--- 888
Query: 704 ALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDL 763
L E E + + KD+E L + GKV E ++L+ + + L +++ ++ +++
Sbjct: 889 DLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEK 948
Query: 764 VVQERNDAQKQLSEEQDARILQ-----DQILTSKQKELEMARKKMNSEISHRHQKEKDLF 818
+ E Q+ S E D R +Q ++I KQ E E +++N + + K+K+L
Sbjct: 949 DMVELGKVQEYKS-ELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKD-NTASLKKKELT 1006
Query: 819 HED 821
+D
Sbjct: 1007 LKD 1009
Score = 32.7 bits (73), Expect = 2.6
Identities = 17/40 (42%), Positives = 23/40 (57%)
Query: 74 HDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRK 113
+ +R +L ++HRAA GD VEH L +D RDRK
Sbjct: 156 YHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVRDRK 195
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sapiens]
Length = 823
Score = 271 bits (692), Expect = 4e-72
Identities = 185/490 (37%), Positives = 272/490 (55%), Gaps = 67/490 (13%)
Query: 649 LKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQE 708
++L N CD + S L++ +K Q + KE +D R LKQE
Sbjct: 397 IQLSENICDSTS----------SAAAGRLTQQRKIGKTYPQQFPKKLKEEHD-RCTLKQE 445
Query: 709 NEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQER 768
NEEK N +MLY K+ E+L KE
Sbjct: 446 NEEKTNVNMLYKKNREELERKE-------------------------------------- 467
Query: 769 NDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEI 828
KQ +E +A+ L+ + + + K + AR N + H H++ K L E+C+L+ +I
Sbjct: 468 ----KQYKKEVEAKQLEPTVQSLEMKS-KTARNTPNRDF-HNHEEMKGLMDENCILKADI 521
Query: 829 ALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNL 888
A+LR EI T+KN N +KE KY +DI+ VKE N L+K IKLNEE +TET +Y +LN+L
Sbjct: 522 AILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDL 581
Query: 889 TAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQS-QTARDLKLDFQRTRQEW 947
AEN LN+EL K++++RLE ++ESY+ RLAAA+ +S +T R+LKL +RTR
Sbjct: 582 KAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRD-- 639
Query: 948 VRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDL 1007
V + +M +S ++ +NE L+E+LS + K N+L+ + TRD+L ++SL LE VQ DL
Sbjct: 640 VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDL 699
Query: 1008 SQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQE 1067
SQTQ Q +E ++MYQ ++K+ K VEER+ LQ EN L QQLDD H+K + +E
Sbjct: 700 SQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKE 759
Query: 1068 KTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDL 1127
++ IQ F ES K+ L L+EK+K+LM+E +HLKE + Q E+EK + +
Sbjct: 760 IVTN-IQRGF--------IESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSI 810
Query: 1128 TEAQETVPSR 1137
E + SR
Sbjct: 811 KEDKYFQTSR 820
Score = 58.9 bits (141), Expect = 3e-08
Identities = 100/483 (20%), Positives = 199/483 (41%), Gaps = 84/483 (17%)
Query: 478 SLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSN 537
+LP S+ E + E +Q K N N K E +QL +++ + S
Sbjct: 363 ALPVASEEEQERHERSEKKQPQVKEGNNTN---------KSEKIQLSENICD------ST 407
Query: 538 STELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIY----PEAD 593
S+ +G LT +G QQ P+K EHDR K NE+ N +Y E +
Sbjct: 408 SSAAAGRLTQQRKIGKT---YPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELE 464
Query: 594 FADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPR-----------IQDTF 642
+ E+ ++ E + ++ L M+ K + + P + D
Sbjct: 465 RKEKQYKKEVEAKQLEPT----------VQSLEMKSKTARNTPNRDFHNHEEMKGLMDEN 514
Query: 643 CLCE-HLLKLKNNHC----DQLTVKLKQMENMVSVLQNELSETKKTKLQLEL---QKIEW 694
C+ + + L+ C D L + K ++++ V + + K KL E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRY 574
Query: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754
++EL D LK EN + NA++L K+S++ R++ + + + +L + + + +
Sbjct: 575 QQELND----LKAEN-TRLNAELLKEKESKK-RLEAD----IESYQSRLAAAISKHSESV 624
Query: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814
+T R NL L ++ D Q+ + I K + + + ++I K+
Sbjct: 625 KTER-NLKLALERTRDVSVQVE-------MSSAISKVKDENEFLTEQLSETQIKFNALKD 676
Query: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKE-KKYFEDIEAVKEKNDNLQKIIKLNEET 873
K D + ++ +AL ++ D + Q + +E K+ +++ EA K+N T
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEA------------KVNNST 724
Query: 874 LTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTA 933
++ ++ +L EN L +L++ Q ++ EI R + + +D + +
Sbjct: 725 GKWNCVE--ERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKS 782
Query: 934 RDL 936
+ L
Sbjct: 783 KKL 785
Score = 32.3 bits (72), Expect = 3.3
Identities = 16/32 (50%), Positives = 21/32 (65%)
Query: 215 ENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246
+N ++ AEQ + SEEEQER + E KQPQ
Sbjct: 353 KNVQTLRAEQALPVASEEEQERHERSEKKQPQ 384
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sapiens]
Length = 823
Score = 270 bits (689), Expect = 1e-71
Identities = 185/490 (37%), Positives = 271/490 (55%), Gaps = 67/490 (13%)
Query: 649 LKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQE 708
++L N CD + S L++ +K Q + KE +D R LKQE
Sbjct: 397 IQLSENICDSTS----------SAAAGRLTQQRKIGKTYPQQFPKKLKEEHD-RCTLKQE 445
Query: 709 NEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQER 768
NEEK N +MLY K+ E+L KE
Sbjct: 446 NEEKTNVNMLYKKNREELERKE-------------------------------------- 467
Query: 769 NDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEI 828
KQ +E +A+ L+ + + + K + AR N + H H++ K L E+C+L+ +I
Sbjct: 468 ----KQYKKEVEAKQLEPTVQSLEMKS-KTARNTPNRDF-HNHEEMKGLMDENCILKADI 521
Query: 829 ALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNL 888
A+LR EI T+KN N +KE KY +DI+ VKE N L+K IKLNEE +TET +Y +LN L
Sbjct: 522 AILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNYL 581
Query: 889 TAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQS-QTARDLKLDFQRTRQEW 947
AEN LN+EL K++++RLE ++ESY+ RLAAA+ +S +T R+LKL +RTR
Sbjct: 582 KAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRD-- 639
Query: 948 VRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDL 1007
V + +M +S ++ +NE L+E+LS + K N+L+ + TRD+L ++SL LE VQ DL
Sbjct: 640 VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDL 699
Query: 1008 SQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQE 1067
SQTQ Q +E ++MYQ ++K+ K VEER+ LQ EN L QQLDD H+K + +E
Sbjct: 700 SQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKE 759
Query: 1068 KTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDL 1127
++ IQ F ES K+ L L+EK+K+LM+E +HLKE + Q E+EK + +
Sbjct: 760 IVTN-IQRGF--------IESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSI 810
Query: 1128 TEAQETVPSR 1137
E + SR
Sbjct: 811 KEDKYFQTSR 820
Score = 55.8 bits (133), Expect = 3e-07
Identities = 99/483 (20%), Positives = 198/483 (40%), Gaps = 84/483 (17%)
Query: 478 SLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSN 537
+LP S+ E + E +Q K N N K E +QL +++ + S
Sbjct: 363 ALPVASEEEQERHERSEKKQPQVKEGNNTN---------KSEKIQLSENICD------ST 407
Query: 538 STELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIY----PEAD 593
S+ +G LT +G QQ P+K EHDR K NE+ N +Y E +
Sbjct: 408 SSAAAGRLTQQRKIGKT---YPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELE 464
Query: 594 FADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPR-----------IQDTF 642
+ E+ ++ E + ++ L M+ K + + P + D
Sbjct: 465 RKEKQYKKEVEAKQLEPT----------VQSLEMKSKTARNTPNRDFHNHEEMKGLMDEN 514
Query: 643 CLCE-HLLKLKNNHC----DQLTVKLKQMENMVSVLQNELSETKKTKLQLEL---QKIEW 694
C+ + + L+ C D L + K ++++ V + + K KL E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRY 574
Query: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754
++EL LK EN + NA++L K+S++ R++ + + + +L + + + +
Sbjct: 575 QQELN----YLKAEN-TRLNAELLKEKESKK-RLEAD----IESYQSRLAAAISKHSESV 624
Query: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814
+T R NL L ++ D Q+ + I K + + + ++I K+
Sbjct: 625 KTER-NLKLALERTRDVSVQVE-------MSSAISKVKDENEFLTEQLSETQIKFNALKD 676
Query: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKE-KKYFEDIEAVKEKNDNLQKIIKLNEET 873
K D + ++ +AL ++ D + Q + +E K+ +++ EA K+N T
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEA------------KVNNST 724
Query: 874 LTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTA 933
++ ++ +L EN L +L++ Q ++ EI R + + +D + +
Sbjct: 725 GKWNCVE--ERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKS 782
Query: 934 RDL 936
+ L
Sbjct: 783 KKL 785
Score = 32.3 bits (72), Expect = 3.3
Identities = 16/32 (50%), Positives = 21/32 (65%)
Query: 215 ENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246
+N ++ AEQ + SEEEQER + E KQPQ
Sbjct: 353 KNVQTLRAEQALPVASEEEQERHERSEKKQPQ 384
>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
sapiens]
Length = 823
Score = 265 bits (676), Expect = 3e-70
Identities = 182/490 (37%), Positives = 271/490 (55%), Gaps = 67/490 (13%)
Query: 649 LKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQE 708
++L N CD + S L++ +K Q + KE +D R LKQE
Sbjct: 397 IQLSENICDSTS----------SAAAGRLTQQRKIGKTYPQQFPKKLKEEHD-RCTLKQE 445
Query: 709 NEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQER 768
NEEK N +MLY K+ E+L KE
Sbjct: 446 NEEKTNVNMLYKKNREELERKE-------------------------------------- 467
Query: 769 NDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEI 828
KQ +E +A+ L+ + + + K + AR N + H H++ K L E+C+L+ +I
Sbjct: 468 ----KQYKKEVEAKQLEPTVQSLEMKS-KTARNTPNWDF-HNHEEMKGLMDENCILKADI 521
Query: 829 ALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNL 888
A+LR EI T+KN N +KE KY +DI+ VKE N L+K IKLNEE +TET +Y +LN+L
Sbjct: 522 AILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDL 581
Query: 889 TAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQS-QTARDLKLDFQRTRQEW 947
AEN LN+EL K++++RLE ++ESY+ RLAAA+ +S +T R+LKL +RT+
Sbjct: 582 KAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTQD-- 639
Query: 948 VRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDL 1007
V + +M +S ++ +NE L+E+LS + K N+L+ + TRD+L ++SL LE VQ +L
Sbjct: 640 VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNNL 699
Query: 1008 SQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQE 1067
SQTQ Q +E ++MYQ ++K+ K VEER+ LQ EN L QQLDD H+K + +E
Sbjct: 700 SQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKE 759
Query: 1068 KTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDL 1127
++ IQ F ES K+ L+EK+K+LM+E +HLKE + Q E+EK + +
Sbjct: 760 IVTN-IQRGF--------IESGKKDFVLEEKSKKLMNECDHLKESLFQYEREKTEVVVSI 810
Query: 1128 TEAQETVPSR 1137
E + SR
Sbjct: 811 KEDKYFQTSR 820
Score = 56.2 bits (134), Expect = 2e-07
Identities = 101/472 (21%), Positives = 195/472 (41%), Gaps = 82/472 (17%)
Query: 478 SLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSN 537
+LP S+ + + E +Q K N N K E +QL +++ + S
Sbjct: 363 ALPVASEEEQQRHERSEKKQPQVKEGNNTN---------KSEKIQLSENICD------ST 407
Query: 538 STELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIY----PEAD 593
S+ +G LT +G QQ P+K EHDR K NE+ N +Y E +
Sbjct: 408 SSAAAGRLTQQRKIGKT---YPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELE 464
Query: 594 FADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPR-----------IQDTF 642
+ E+ ++ E + ++ L M+ K + + P + D
Sbjct: 465 RKEKQYKKEVEAKQLEPT----------VQSLEMKSKTARNTPNWDFHNHEEMKGLMDEN 514
Query: 643 CLCE-HLLKLKNNHC----DQLTVKLKQMENMVSVLQNELSETKKTKLQLEL---QKIEW 694
C+ + + L+ C D L + K ++++ V + + K KL E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRY 574
Query: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754
++EL D LK EN + NA++L K+S++ R++ + + + +L + + + +
Sbjct: 575 QQELND----LKAEN-TRLNAELLKEKESKK-RLEAD----IESYQSRLAAAISKHSESV 624
Query: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814
+T R NL L ++ D Q+ E + I SK K+ + SE +
Sbjct: 625 KTER-NLKLALERTQDVSVQV--EMSSAI-------SKVKDENEFLTEQLSETQIKFNAL 674
Query: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETL 874
KD F + ++ + L ++T++N Q + + + +KE N + K+N T
Sbjct: 675 KDKFRK---TRDSLRKKSLALETVQNNLSQTQ----QQTQEMKEMYQNAE--AKVNNSTG 725
Query: 875 TETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRD 926
++ ++ +L EN L +L++ Q ++ EI R + + +D
Sbjct: 726 KWNCVE--ERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKD 775
Score = 31.2 bits (69), Expect = 7.5
Identities = 15/32 (46%), Positives = 21/32 (65%)
Query: 215 ENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246
+N ++ AEQ + SEEEQ+R + E KQPQ
Sbjct: 353 KNVQTLRAEQALPVASEEEQQRHERSEKKQPQ 384
>gi|239754871 PREDICTED: similar to Coiled-coil domain-containing
protein 144C [Homo sapiens]
Length = 264
Score = 189 bits (479), Expect = 2e-47
Identities = 110/213 (51%), Positives = 136/213 (63%), Gaps = 33/213 (15%)
Query: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754
E E Y RL LKQE E++++ADMLY K SE+L+ KEEE GK VE QQLK L+ EL
Sbjct: 85 ENEEYH-RLTLKQEEEKRKDADMLYKKGSEELKRKEEEYGKDVEINQQLKRTLKTRAMEL 143
Query: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814
RTVR NLD + + EIS H+KE
Sbjct: 144 RTVRKNLDQTFGNLHS--------------------------------LRFEISLSHKKE 171
Query: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETL 874
K L HE+ MLQEEIA+LRLE+DTIK+QN+ KEKKYFEDIE+VKE++DNL K I LNEE L
Sbjct: 172 KGLLHENSMLQEEIAMLRLELDTIKHQNEIKEKKYFEDIESVKEEHDNLLKAITLNEEAL 231
Query: 875 TETILQYSGQLNNLTAENKILNSELENGKQNQE 907
+T+ QY+GQL+ LT ENK+L+SEL+N K N+E
Sbjct: 232 AKTVFQYNGQLSILTTENKMLSSELKNVKHNKE 264
Score = 72.8 bits (177), Expect = 2e-12
Identities = 65/255 (25%), Positives = 113/255 (44%), Gaps = 35/255 (13%)
Query: 520 DVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGL----------NQQIPRKENGE 569
+++L VEEEM++HRSN+ +S LTDG T GN DDGL NQQ P EN E
Sbjct: 29 NIKLPLKVEEEMQRHRSNNVGISENLTDGATAGNGDDGLIPQRKSRKPENQQFPSTENEE 88
Query: 570 HDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEY 629
+ R K EK + + +Y + + E +D E++ + +LR
Sbjct: 89 YHRLTLKQEEEKRKDADMLYKKGS-EELKRKEEEYGKDVEINQQLKRTLKTRAMELRTVR 147
Query: 630 KDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLEL 689
K+ + TF N H + + L + + +N + + + L+LEL
Sbjct: 148 KN------LDQTF---------GNLHSLRFEISLSHKKEKGLLHENSMLQEEIAMLRLEL 192
Query: 690 QKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVV-ETKQQLK---W 745
I+ + E+ + + E+ ++ + ++L + + + EE K V + QL
Sbjct: 193 DTIKHQNEIKEKKYFEDIESVKEEHDNLL-----KAITLNEEALAKTVFQYNGQLSILTT 247
Query: 746 NLRRLVKELRTVRNN 760
+ L EL+ V++N
Sbjct: 248 ENKMLSSELKNVKHN 262
Score = 33.1 bits (74), Expect = 2.0
Identities = 30/124 (24%), Positives = 56/124 (45%), Gaps = 14/124 (11%)
Query: 185 NLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDS--ELTSEEEQERLKGCEN 242
N+ E + G +G+D L +S+ PEN++ E + LT ++E+E+ K +
Sbjct: 47 NVGISENLTDGATAGNGDDGLIPQRKSRKPENQQFPSTENEEYHRLTLKQEEEKRKDADM 106
Query: 243 KQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQRF 302
+K S+E + ++ +D+ I L K+ M +L+ V L Q F
Sbjct: 107 LY-KKGSEELKRKEEEYGKDVEINQQLKRTLKTRAM-----------ELRTVRKNLDQTF 154
Query: 303 GEIY 306
G ++
Sbjct: 155 GNLH 158
>gi|239749410 PREDICTED: similar to Coiled-coil domain-containing
protein 144C [Homo sapiens]
Length = 264
Score = 189 bits (479), Expect = 2e-47
Identities = 110/213 (51%), Positives = 136/213 (63%), Gaps = 33/213 (15%)
Query: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754
E E Y RL LKQE E++++ADMLY K SE+L+ KEEE GK VE QQLK L+ EL
Sbjct: 85 ENEEYH-RLTLKQEEEKRKDADMLYKKGSEELKRKEEEYGKDVEINQQLKRTLKTRAMEL 143
Query: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814
RTVR NLD + + EIS H+KE
Sbjct: 144 RTVRKNLDQTFGNLHS--------------------------------LRFEISLSHKKE 171
Query: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETL 874
K L HE+ MLQEEIA+LRLE+DTIK+QN+ KEKKYFEDIE+VKE++DNL K I LNEE L
Sbjct: 172 KGLLHENSMLQEEIAMLRLELDTIKHQNEIKEKKYFEDIESVKEEHDNLLKAITLNEEAL 231
Query: 875 TETILQYSGQLNNLTAENKILNSELENGKQNQE 907
+T+ QY+GQL+ LT ENK+L+SEL+N K N+E
Sbjct: 232 AKTVFQYNGQLSILTTENKMLSSELKNVKHNKE 264
Score = 72.8 bits (177), Expect = 2e-12
Identities = 65/255 (25%), Positives = 113/255 (44%), Gaps = 35/255 (13%)
Query: 520 DVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGL----------NQQIPRKENGE 569
+++L VEEEM++HRSN+ +S LTDG T GN DDGL NQQ P EN E
Sbjct: 29 NIKLPLKVEEEMQRHRSNNVGISENLTDGATAGNGDDGLIPQRKSRKPENQQFPSTENEE 88
Query: 570 HDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEY 629
+ R K EK + + +Y + + E +D E++ + +LR
Sbjct: 89 YHRLTLKQEEEKRKDADMLYKKGS-EELKRKEEEYGKDVEINQQLKRTLKTRAMELRTVR 147
Query: 630 KDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLEL 689
K+ + TF N H + + L + + +N + + + L+LEL
Sbjct: 148 KN------LDQTF---------GNLHSLRFEISLSHKKEKGLLHENSMLQEEIAMLRLEL 192
Query: 690 QKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVV-ETKQQLK---W 745
I+ + E+ + + E+ ++ + ++L + + + EE K V + QL
Sbjct: 193 DTIKHQNEIKEKKYFEDIESVKEEHDNLL-----KAITLNEEALAKTVFQYNGQLSILTT 247
Query: 746 NLRRLVKELRTVRNN 760
+ L EL+ V++N
Sbjct: 248 ENKMLSSELKNVKHN 262
Score = 33.1 bits (74), Expect = 2.0
Identities = 30/124 (24%), Positives = 56/124 (45%), Gaps = 14/124 (11%)
Query: 185 NLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDS--ELTSEEEQERLKGCEN 242
N+ E + G +G+D L +S+ PEN++ E + LT ++E+E+ K +
Sbjct: 47 NVGISENLTDGATAGNGDDGLIPQRKSRKPENQQFPSTENEEYHRLTLKQEEEKRKDADM 106
Query: 243 KQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQRF 302
+K S+E + ++ +D+ I L K+ M +L+ V L Q F
Sbjct: 107 LY-KKGSEELKRKEEEYGKDVEINQQLKRTLKTRAM-----------ELRTVRKNLDQTF 154
Query: 303 GEIY 306
G ++
Sbjct: 155 GNLH 158
>gi|239743545 PREDICTED: hypothetical protein XP_002342885 [Homo
sapiens]
Length = 264
Score = 189 bits (479), Expect = 2e-47
Identities = 110/213 (51%), Positives = 136/213 (63%), Gaps = 33/213 (15%)
Query: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754
E E Y RL LKQE E++++ADMLY K SE+L+ KEEE GK VE QQLK L+ EL
Sbjct: 85 ENEEYH-RLTLKQEEEKRKDADMLYKKGSEELKRKEEEYGKDVEINQQLKRTLKTRAMEL 143
Query: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814
RTVR NLD + + EIS H+KE
Sbjct: 144 RTVRKNLDQTFGNLHS--------------------------------LRFEISLSHKKE 171
Query: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETL 874
K L HE+ MLQEEIA+LRLE+DTIK+QN+ KEKKYFEDIE+VKE++DNL K I LNEE L
Sbjct: 172 KGLLHENSMLQEEIAMLRLELDTIKHQNEIKEKKYFEDIESVKEEHDNLLKAITLNEEAL 231
Query: 875 TETILQYSGQLNNLTAENKILNSELENGKQNQE 907
+T+ QY+GQL+ LT ENK+L+SEL+N K N+E
Sbjct: 232 AKTVFQYNGQLSILTTENKMLSSELKNVKHNKE 264
Score = 72.8 bits (177), Expect = 2e-12
Identities = 65/255 (25%), Positives = 113/255 (44%), Gaps = 35/255 (13%)
Query: 520 DVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGL----------NQQIPRKENGE 569
+++L VEEEM++HRSN+ +S LTDG T GN DDGL NQQ P EN E
Sbjct: 29 NIKLPLKVEEEMQRHRSNNVGISENLTDGATAGNGDDGLIPQRKSRKPENQQFPSTENEE 88
Query: 570 HDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEY 629
+ R K EK + + +Y + + E +D E++ + +LR
Sbjct: 89 YHRLTLKQEEEKRKDADMLYKKGS-EELKRKEEEYGKDVEINQQLKRTLKTRAMELRTVR 147
Query: 630 KDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLEL 689
K+ + TF N H + + L + + +N + + + L+LEL
Sbjct: 148 KN------LDQTF---------GNLHSLRFEISLSHKKEKGLLHENSMLQEEIAMLRLEL 192
Query: 690 QKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVV-ETKQQLK---W 745
I+ + E+ + + E+ ++ + ++L + + + EE K V + QL
Sbjct: 193 DTIKHQNEIKEKKYFEDIESVKEEHDNLL-----KAITLNEEALAKTVFQYNGQLSILTT 247
Query: 746 NLRRLVKELRTVRNN 760
+ L EL+ V++N
Sbjct: 248 ENKMLSSELKNVKHN 262
Score = 33.1 bits (74), Expect = 2.0
Identities = 30/124 (24%), Positives = 56/124 (45%), Gaps = 14/124 (11%)
Query: 185 NLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDS--ELTSEEEQERLKGCEN 242
N+ E + G +G+D L +S+ PEN++ E + LT ++E+E+ K +
Sbjct: 47 NVGISENLTDGATAGNGDDGLIPQRKSRKPENQQFPSTENEEYHRLTLKQEEEKRKDADM 106
Query: 243 KQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQRF 302
+K S+E + ++ +D+ I L K+ M +L+ V L Q F
Sbjct: 107 LY-KKGSEELKRKEEEYGKDVEINQQLKRTLKTRAM-----------ELRTVRKNLDQTF 154
Query: 303 GEIY 306
G ++
Sbjct: 155 GNLH 158
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,887,440
Number of Sequences: 37866
Number of extensions: 2584440
Number of successful extensions: 24567
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 329
Number of HSP's successfully gapped in prelim test: 1281
Number of HSP's that attempted gapping in prelim test: 11766
Number of HSP's gapped (non-prelim): 7503
length of query: 1427
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1312
effective length of database: 13,892,928
effective search space: 18227521536
effective search space used: 18227521536
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.