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Search of human proteins with 14916483
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14916483 caspase 6 isoform alpha preproprotein [Homo
sapiens]
(293 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 608 e-174
gi|14916485 caspase 6 isoform beta [Homo sapiens] 396 e-110
gi|14790115 caspase 3 preproprotein [Homo sapiens] 204 1e-52
gi|14790119 caspase 3 preproprotein [Homo sapiens] 204 1e-52
gi|15718698 caspase 7 isoform delta [Homo sapiens] 184 8e-47
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 184 8e-47
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 184 8e-47
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 132 5e-31
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 129 2e-30
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 129 2e-30
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 129 2e-30
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 129 2e-30
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 129 2e-30
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 126 3e-29
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 115 6e-26
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 114 8e-26
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 110 2e-24
gi|6912286 caspase 14 precursor [Homo sapiens] 82 4e-16
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap... 71 1e-12
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap... 71 1e-12
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 65 9e-11
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 65 9e-11
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 65 9e-11
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [... 65 9e-11
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [... 65 9e-11
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 65 9e-11
gi|209870073 caspase 5 isoform c [Homo sapiens] 65 9e-11
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 65 9e-11
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 65 9e-11
gi|15718702 caspase 7 isoform beta [Homo sapiens] 62 8e-10
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 608 bits (1567), Expect = e-174
Identities = 293/293 (100%), Positives = 293/293 (100%)
Query: 1 MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT 60
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT
Sbjct: 1 MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT 60
Query: 61 LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS 120
LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS
Sbjct: 61 LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS 120
Query: 121 HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN 180
HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN
Sbjct: 121 HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN 180
Query: 181 QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG 240
QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG
Sbjct: 181 QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG 240
Query: 241 SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN 293
SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
Sbjct: 241 SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN 293
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 396 bits (1017), Expect = e-110
Identities = 191/191 (100%), Positives = 191/191 (100%)
Query: 103 VSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQA 162
VSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQA
Sbjct: 14 VSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQA 73
Query: 163 CRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRET 222
CRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRET
Sbjct: 74 CRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRET 133
Query: 223 VNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASML 282
VNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASML
Sbjct: 134 VNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASML 193
Query: 283 TKKLHFFPKSN 293
TKKLHFFPKSN
Sbjct: 194 TKKLHFFPKSN 204
Score = 32.7 bits (73), Expect = 0.39
Identities = 15/25 (60%), Positives = 17/25 (68%)
Query: 1 MSSASGLRRGHPAGGEENMTETDAF 25
MSSASGLRRGHPA + + D F
Sbjct: 1 MSSASGLRRGHPAVSTVSHADADCF 25
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 204 bits (518), Expect = 1e-52
Identities = 105/253 (41%), Positives = 147/253 (58%), Gaps = 13/253 (5%)
Query: 37 YKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEEL 96
YKMD+ G+ +I N++ F + R GT D NL F +L +EV+ NDL EE+
Sbjct: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Query: 97 LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPK 156
+ + +VS H+ FVCV LSHGE I+ + ++++ +T F+GD+C SL GKPK
Sbjct: 97 VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
Query: 157 IFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGY 216
+FIIQACRG + D + +T+ D + + +P ADFL YS A GY
Sbjct: 157 LFIIQACRGTELDCGI-------------ETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203
Query: 217 YSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVP 276
YS R + +GSW+IQ LC ML +Y LEF +LT VNRKV+ F D + KKQ+P
Sbjct: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263
Query: 277 CFASMLTKKLHFF 289
C SMLTK+L+F+
Sbjct: 264 CIVSMLTKELYFY 276
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 204 bits (518), Expect = 1e-52
Identities = 105/253 (41%), Positives = 147/253 (58%), Gaps = 13/253 (5%)
Query: 37 YKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEEL 96
YKMD+ G+ +I N++ F + R GT D NL F +L +EV+ NDL EE+
Sbjct: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Query: 97 LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPK 156
+ + +VS H+ FVCV LSHGE I+ + ++++ +T F+GD+C SL GKPK
Sbjct: 97 VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
Query: 157 IFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGY 216
+FIIQACRG + D + +T+ D + + +P ADFL YS A GY
Sbjct: 157 LFIIQACRGTELDCGI-------------ETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203
Query: 217 YSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVP 276
YS R + +GSW+IQ LC ML +Y LEF +LT VNRKV+ F D + KKQ+P
Sbjct: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263
Query: 277 CFASMLTKKLHFF 289
C SMLTK+L+F+
Sbjct: 264 CIVSMLTKELYFY 276
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 184 bits (467), Expect = 8e-47
Identities = 98/256 (38%), Positives = 140/256 (54%), Gaps = 10/256 (3%)
Query: 33 PAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLK 92
P +Y M+ + G +I N++ F + R GT D + L + F LGF+V +ND
Sbjct: 89 PTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS 148
Query: 93 AEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLV 152
++ + + S H +A CF C+ LSHGE N IY D I+ LT F+GD+C +L+
Sbjct: 149 CAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLL 208
Query: 153 GKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSV 212
KPK+F IQACRG + +D+ + I + DA Y +P ADFL YS
Sbjct: 209 EKPKLFFIQACRGTE----------LDDGIQADSGPINDTDANPRYKIPVEADFLFAYST 258
Query: 213 AEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGK 272
GYYS R GSW++Q LC +L ++G LE ++LT VN +V++ DP K
Sbjct: 259 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 318
Query: 273 KQVPCFASMLTKKLHF 288
KQ+PC SMLTK+L+F
Sbjct: 319 KQIPCVVSMLTKELYF 334
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 184 bits (467), Expect = 8e-47
Identities = 98/256 (38%), Positives = 140/256 (54%), Gaps = 10/256 (3%)
Query: 33 PAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLK 92
P +Y M+ + G +I N++ F + R GT D + L + F LGF+V +ND
Sbjct: 56 PTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS 115
Query: 93 AEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLV 152
++ + + S H +A CF C+ LSHGE N IY D I+ LT F+GD+C +L+
Sbjct: 116 CAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLL 175
Query: 153 GKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSV 212
KPK+F IQACRG + +D+ + I + DA Y +P ADFL YS
Sbjct: 176 EKPKLFFIQACRGTE----------LDDGIQADSGPINDTDANPRYKIPVEADFLFAYST 225
Query: 213 AEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGK 272
GYYS R GSW++Q LC +L ++G LE ++LT VN +V++ DP K
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 285
Query: 273 KQVPCFASMLTKKLHF 288
KQ+PC SMLTK+L+F
Sbjct: 286 KQIPCVVSMLTKELYF 301
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 184 bits (467), Expect = 8e-47
Identities = 98/256 (38%), Positives = 140/256 (54%), Gaps = 10/256 (3%)
Query: 33 PAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLK 92
P +Y M+ + G +I N++ F + R GT D + L + F LGF+V +ND
Sbjct: 56 PTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS 115
Query: 93 AEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLV 152
++ + + S H +A CF C+ LSHGE N IY D I+ LT F+GD+C +L+
Sbjct: 116 CAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLL 175
Query: 153 GKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSV 212
KPK+F IQACRG + +D+ + I + DA Y +P ADFL YS
Sbjct: 176 EKPKLFFIQACRGTE----------LDDGIQADSGPINDTDANPRYKIPVEADFLFAYST 225
Query: 213 AEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGK 272
GYYS R GSW++Q LC +L ++G LE ++LT VN +V++ DP K
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 285
Query: 273 KQVPCFASMLTKKLHF 288
KQ+PC SMLTK+L+F
Sbjct: 286 KQIPCVVSMLTKELYF 301
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 132 bits (331), Expect = 5e-31
Identities = 98/278 (35%), Positives = 140/278 (50%), Gaps = 20/278 (7%)
Query: 14 GGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN 73
G EE +++TD E A Y+M+ RG+ +I N+ F +L +R+GT D +
Sbjct: 210 GEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEI 266
Query: 74 LTRRFSDLGFEVKCFNDLKAEELLLKIHEVS-TVSHADADCFVCVFLSHGEGNHIYAYD- 131
L+ F LGF V N++ E+ + + + +HAD DCFV L+HG +Y+ D
Sbjct: 267 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE 326
Query: 132 AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITE 191
A I I+ + F +C L KPK+F IQAC+G + P + ++ E+ T++ +
Sbjct: 327 ALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQ-PSVSIEADALNPEQAPTSLQD 385
Query: 192 VDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLE-FTELLT 250
++PA ADFL+ + GY S R GSWYIQ LC L K E +LT
Sbjct: 386 -------SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILT 438
Query: 251 LVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHF 288
VN VS RRVD KKQ+P A L KKL F
Sbjct: 439 AVNDDVS-RRVD-----KQGTKKQMPQPAFTLRKKLVF 470
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 129 bits (325), Expect = 2e-30
Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)
Query: 37 YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
Y+M + RG LI N+ F ++ +R GT D LT F +L FE+K +
Sbjct: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344
Query: 90 DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
D E++ +LKI+++ + H++ DCF+C LSHG+ IY D + I LT F G
Sbjct: 345 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 402
Query: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
KC SL GKPK+F IQAC+G+ Q +PV +T+ + E+D +S T +P
Sbjct: 403 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 454
Query: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
ADFL+ + S+R G+WYIQ LC+ L + + +LT VN +VS
Sbjct: 455 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 511
Query: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
KD KQ+P L KKL F
Sbjct: 512 ---KDDKKNMGKQMPQPTFTLRKKLVF 535
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 129 bits (325), Expect = 2e-30
Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)
Query: 37 YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
Y+M + RG LI N+ F ++ +R GT D LT F +L FE+K +
Sbjct: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Query: 90 DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
D E++ +LKI+++ + H++ DCF+C LSHG+ IY D + I LT F G
Sbjct: 271 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328
Query: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
KC SL GKPK+F IQAC+G+ Q +PV +T+ + E+D +S T +P
Sbjct: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 380
Query: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
ADFL+ + S+R G+WYIQ LC+ L + + +LT VN +VS
Sbjct: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 437
Query: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
KD KQ+P L KKL F
Sbjct: 438 ---KDDKKNMGKQMPQPTFTLRKKLVF 461
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 129 bits (325), Expect = 2e-30
Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)
Query: 37 YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
Y+M + RG LI N+ F ++ +R GT D LT F +L FE+K +
Sbjct: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Query: 90 DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
D E++ +LKI+++ + H++ DCF+C LSHG+ IY D + I LT F G
Sbjct: 271 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328
Query: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
KC SL GKPK+F IQAC+G+ Q +PV +T+ + E+D +S T +P
Sbjct: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 380
Query: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
ADFL+ + S+R G+WYIQ LC+ L + + +LT VN +VS
Sbjct: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 437
Query: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
KD KQ+P L KKL F
Sbjct: 438 ---KDDKKNMGKQMPQPTFTLRKKLVF 461
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 129 bits (325), Expect = 2e-30
Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)
Query: 37 YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
Y+M + RG LI N+ F ++ +R GT D LT F +L FE+K +
Sbjct: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285
Query: 90 DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
D E++ +LKI+++ + H++ DCF+C LSHG+ IY D + I LT F G
Sbjct: 286 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 343
Query: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
KC SL GKPK+F IQAC+G+ Q +PV +T+ + E+D +S T +P
Sbjct: 344 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 395
Query: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
ADFL+ + S+R G+WYIQ LC+ L + + +LT VN +VS
Sbjct: 396 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 452
Query: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
KD KQ+P L KKL F
Sbjct: 453 ---KDDKKNMGKQMPQPTFTLRKKLVF 476
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 129 bits (325), Expect = 2e-30
Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)
Query: 37 YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
Y+M + RG LI N+ F ++ +R GT D LT F +L FE+K +
Sbjct: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302
Query: 90 DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
D E++ +LKI+++ + H++ DCF+C LSHG+ IY D + I LT F G
Sbjct: 303 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 360
Query: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
KC SL GKPK+F IQAC+G+ Q +PV +T+ + E+D +S T +P
Sbjct: 361 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 412
Query: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
ADFL+ + S+R G+WYIQ LC+ L + + +LT VN +VS
Sbjct: 413 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 469
Query: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
KD KQ+P L KKL F
Sbjct: 470 ---KDDKKNMGKQMPQPTFTLRKKLVF 493
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 126 bits (316), Expect = 3e-29
Identities = 96/278 (34%), Positives = 137/278 (49%), Gaps = 25/278 (8%)
Query: 14 GGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN 73
G N ++ KR A Y+M+ RG+ +I N+ F +L +R+GT D +
Sbjct: 258 GASANTLNSETSTKR-----AAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEI 309
Query: 74 LTRRFSDLGFEVKCFNDLKAEELLLKIHEVS-TVSHADADCFVCVFLSHGEGNHIYAYD- 131
L+ F LGF V N++ E+ + + + +HAD DCFV L+HG +Y+ D
Sbjct: 310 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE 369
Query: 132 AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITE 191
A I I+ + F +C L KPK+F IQAC+G + P + ++ E+ T++ +
Sbjct: 370 ALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQ-PSVSIEADALNPEQAPTSLQD 428
Query: 192 VDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLE-FTELLT 250
++PA ADFL+ + GY S R GSWYIQ LC L K E +LT
Sbjct: 429 -------SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILT 481
Query: 251 LVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHF 288
VN VS RRVD KKQ+P A L KKL F
Sbjct: 482 AVNDDVS-RRVD-----KQGTKKQMPQPAFTLRKKLVF 513
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 115 bits (287), Expect = 6e-26
Identities = 84/265 (31%), Positives = 124/265 (46%), Gaps = 33/265 (12%)
Query: 45 GIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVS 104
G LI N+ F L R G+ D + L RRFS L F V+ DL A++++L + E++
Sbjct: 161 GHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELA 220
Query: 105 TVSHADADCFVCVFLSHG-EGNH------IYAYD-AKIEIQTLTGLFKGDKCHSLVGKPK 156
H DC V V LSHG + +H +Y D + ++ + +F G C SL GKPK
Sbjct: 221 QQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPK 280
Query: 157 IFIIQACRGNQHD-----VPVIPLDVVDNQTEKLDT--------NITEVDAASVYTLPAG 203
+F IQAC G Q D P D + D ++DA S +LP
Sbjct: 281 LFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAIS--SLPTP 338
Query: 204 ADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDF 263
+D + YS G+ S R+ +GSWY++ L ++ ++ S + LL V VS + +
Sbjct: 339 SDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGI-- 396
Query: 264 CKDPSAIGKKQVPCFASMLTKKLHF 288
KQ+P + L KKL F
Sbjct: 397 --------YKQMPGCFNFLRKKLFF 413
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 114 bits (286), Expect = 8e-26
Identities = 75/227 (33%), Positives = 114/227 (50%), Gaps = 18/227 (7%)
Query: 14 GGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN 73
G N ++ KR A Y+M+ RG+ +I N+ F +L +R+GT D +
Sbjct: 258 GASANTLNSETSTKR-----AAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEI 309
Query: 74 LTRRFSDLGFEVKCFNDLKAEELLLKIHEVS-TVSHADADCFVCVFLSHGEGNHIYAYD- 131
L+ F LGF V N++ E+ + + + +HAD DCFV L+HG +Y+ D
Sbjct: 310 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE 369
Query: 132 AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITE 191
A I I+ + F +C L KPK+F IQAC+G + P + ++ E+ T++ +
Sbjct: 370 ALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQ-PSVSIEADALNPEQAPTSLQD 428
Query: 192 VDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGK 238
++PA ADFL+ + GY S R GSWYIQ LC L K
Sbjct: 429 -------SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 110 bits (274), Expect = 2e-24
Identities = 76/260 (29%), Positives = 118/260 (45%), Gaps = 10/260 (3%)
Query: 37 YKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEEL 96
Y++ R RG+AL+ ++ F L R G D L F LG++V D A+E+
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251
Query: 97 LLKIHEVSTV-SHADADCFVCVFLSHGEGNHIYAYDAKI-EIQTLTGLFKGDKCHSLVGK 154
K+ + + +H D + LSHG IY D K+ ++Q + LF C SL K
Sbjct: 252 QEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNK 311
Query: 155 PKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAAS----VYTLPAGADFLMCY 210
PK+F IQACRG++ D V D D + E DA LP +D + Y
Sbjct: 312 PKMFFIQACRGDETDRGV---DQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGY 368
Query: 211 SVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAI 270
+ +G + R T GSWYI+ L ++ + + ++L VN + R +
Sbjct: 369 ACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDRE-GYAPGTEFH 427
Query: 271 GKKQVPCFASMLTKKLHFFP 290
K++ + S L + L+ FP
Sbjct: 428 RCKEMSEYCSTLCRHLYLFP 447
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 82.4 bits (202), Expect = 4e-16
Identities = 74/257 (28%), Positives = 107/257 (41%), Gaps = 30/257 (11%)
Query: 35 EKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAE 94
EKY M R + L R G+ D D L F L FE D AE
Sbjct: 10 EKYDMSGARLALILCVTKAR----------EGSEEDLDALEHMFRQLRFESTMKRDPTAE 59
Query: 95 EL---LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAK-IEIQTLTGLFKGDKCHS 150
+ L K + C V ++HG + D + ++++ L C +
Sbjct: 60 QFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQA 119
Query: 151 LVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCY 210
L KPK++IIQACRG Q D P + V I V S T+P D L Y
Sbjct: 120 LRAKPKVYIIQACRGEQRD----PGETVGGD------EIVMVIKDSPQTIPTYTDALHVY 169
Query: 211 SVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAI 270
S EGY ++R GS +IQ L ++ K + ELLT V R++++ + ++ A
Sbjct: 170 STVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHI--LELLTEVTRRMAE--AELVQEGKA- 224
Query: 271 GKKQVPCFASMLTKKLH 287
+K P S L K+L+
Sbjct: 225 -RKTNPEIQSTLRKRLY 240
>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
sapiens]
Length = 432
Score = 70.9 bits (172), Expect = 1e-12
Identities = 62/202 (30%), Positives = 92/202 (45%), Gaps = 26/202 (12%)
Query: 81 LGFEVKCFNDLKAE---ELLLKIHEVSTVSHADADCFVCVFLSHG--EGNHIYAYDAKIE 135
LGFE D A+ E L + E C + ++HG G + A +++
Sbjct: 209 LGFETTVRTDPTAQAFQEELAQFREQLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQ 268
Query: 136 IQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDV------------VDNQTE 183
+ L + + +C L G+PKIF++QACRG D V P + V + +
Sbjct: 269 PEAL--MQELSRCQVLQGRPKIFLLQACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHAD 326
Query: 184 KLDTNITEVDAASVYTLPAG----ADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKY 239
L E +S P G AD L YS AEGY ++R+ GS +IQ L E+L +
Sbjct: 327 VLQI-YAEAQGSSCRGTPPGSSDQADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVL-RA 383
Query: 240 GSSLEFTELLTLVNRKVSQRRV 261
+ ELLT VNR+V ++ V
Sbjct: 384 NPGRDLLELLTEVNRRVCEQEV 405
>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
sapiens]
Length = 432
Score = 70.9 bits (172), Expect = 1e-12
Identities = 62/202 (30%), Positives = 92/202 (45%), Gaps = 26/202 (12%)
Query: 81 LGFEVKCFNDLKAE---ELLLKIHEVSTVSHADADCFVCVFLSHG--EGNHIYAYDAKIE 135
LGFE D A+ E L + E C + ++HG G + A +++
Sbjct: 209 LGFETTVRTDPTAQAFQEELAQFREQLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQ 268
Query: 136 IQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDV------------VDNQTE 183
+ L + + +C L G+PKIF++QACRG D V P + V + +
Sbjct: 269 PEAL--MQELSRCQVLQGRPKIFLLQACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHAD 326
Query: 184 KLDTNITEVDAASVYTLPAG----ADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKY 239
L E +S P G AD L YS AEGY ++R+ GS +IQ L E+L +
Sbjct: 327 VLQI-YAEAQGSSCRGTPPGSSDQADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVL-RA 383
Query: 240 GSSLEFTELLTLVNRKVSQRRV 261
+ ELLT VNR+V ++ V
Sbjct: 384 NPGRDLLELLTEVNRRVCEQEV 405
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 64.7 bits (156), Expect = 9e-11
Identities = 70/256 (27%), Positives = 108/256 (42%), Gaps = 22/256 (8%)
Query: 43 RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
R +ALI +E F ++P R G D +T +LG+ V +L A ++ ++
Sbjct: 68 RTRLALIICNEEFD---SIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEA 124
Query: 103 VS-TVSHADADCFVCVFLSHG--EG----NHIYAYDAKIEIQTLTGLFKGDKCHSLVGKP 155
+ H +D VF+SHG EG H +++ + + C SL KP
Sbjct: 125 FAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 184
Query: 156 KIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEG 215
K+ IIQACRG+ V V + L T E + ++ DF+ S
Sbjct: 185 KVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTT-EEFEDDAIKKAHIEKDFIAFCSSTPD 243
Query: 216 YYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV 275
S R GS +I L E + +Y S + E+ RKV R F + P G+ Q+
Sbjct: 244 NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKV---RFSF-EQPD--GRAQM 293
Query: 276 PCFASM-LTKKLHFFP 290
P + LT+ + FP
Sbjct: 294 PTTERVTLTRCFYLFP 309
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 64.7 bits (156), Expect = 9e-11
Identities = 70/256 (27%), Positives = 108/256 (42%), Gaps = 22/256 (8%)
Query: 43 RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
R +ALI +E F ++P R G D +T +LG+ V +L A ++ ++
Sbjct: 161 RTRLALIICNEEFD---SIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEA 217
Query: 103 VS-TVSHADADCFVCVFLSHG--EG----NHIYAYDAKIEIQTLTGLFKGDKCHSLVGKP 155
+ H +D VF+SHG EG H +++ + + C SL KP
Sbjct: 218 FAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 277
Query: 156 KIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEG 215
K+ IIQACRG+ V V + L T E + ++ DF+ S
Sbjct: 278 KVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTT-EEFEDDAIKKAHIEKDFIAFCSSTPD 336
Query: 216 YYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV 275
S R GS +I L E + +Y S + E+ RKV R F + P G+ Q+
Sbjct: 337 NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKV---RFSF-EQPD--GRAQM 386
Query: 276 PCFASM-LTKKLHFFP 290
P + LT+ + FP
Sbjct: 387 PTTERVTLTRCFYLFP 402
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 64.7 bits (156), Expect = 9e-11
Identities = 70/256 (27%), Positives = 108/256 (42%), Gaps = 22/256 (8%)
Query: 43 RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
R +ALI +E F ++P R G D +T +LG+ V +L A ++ ++
Sbjct: 140 RTRLALIICNEEFD---SIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEA 196
Query: 103 VS-TVSHADADCFVCVFLSHG--EG----NHIYAYDAKIEIQTLTGLFKGDKCHSLVGKP 155
+ H +D VF+SHG EG H +++ + + C SL KP
Sbjct: 197 FAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 256
Query: 156 KIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEG 215
K+ IIQACRG+ V V + L T E + ++ DF+ S
Sbjct: 257 KVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTT-EEFEDDAIKKAHIEKDFIAFCSSTPD 315
Query: 216 YYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV 275
S R GS +I L E + +Y S + E+ RKV R F + P G+ Q+
Sbjct: 316 NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKV---RFSF-EQPD--GRAQM 365
Query: 276 PCFASM-LTKKLHFFP 290
P + LT+ + FP
Sbjct: 366 PTTERVTLTRCFYLFP 381
>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 64.7 bits (156), Expect = 9e-11
Identities = 62/235 (26%), Positives = 100/235 (42%), Gaps = 42/235 (17%)
Query: 16 EENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN-- 73
++++ E++AF + + P E+YKM + GI LI + C +
Sbjct: 225 KKSIQESEAFLPQSI--PEERYKMKSKPLGICLIID----------------CIGNETEL 266
Query: 74 LTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTV--------SHADADCFVCVFLSHGEGN 125
L F+ LG+EV+ F L L +H +S + H D D FVCV +S G
Sbjct: 267 LRDTFTSLGYEVQKF-------LHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQ 319
Query: 126 HIYAYD---AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQT 182
+Y D + + + + +F GD C L GKPK+F IQ ++ + L VD
Sbjct: 320 SVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPA 379
Query: 183 EKLDTNIT-EVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML 236
K N+ + + T+ ADF A+ + + S Y+Q L + L
Sbjct: 380 MK---NVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKL 431
>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 64.7 bits (156), Expect = 9e-11
Identities = 62/235 (26%), Positives = 100/235 (42%), Gaps = 42/235 (17%)
Query: 16 EENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN-- 73
++++ E++AF + + P E+YKM + GI LI + C +
Sbjct: 225 KKSIQESEAFLPQSI--PEERYKMKSKPLGICLIID----------------CIGNETEL 266
Query: 74 LTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTV--------SHADADCFVCVFLSHGEGN 125
L F+ LG+EV+ F L L +H +S + H D D FVCV +S G
Sbjct: 267 LRDTFTSLGYEVQKF-------LHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQ 319
Query: 126 HIYAYD---AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQT 182
+Y D + + + + +F GD C L GKPK+F IQ ++ + L VD
Sbjct: 320 SVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPA 379
Query: 183 EKLDTNIT-EVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML 236
K N+ + + T+ ADF A+ + + S Y+Q L + L
Sbjct: 380 MK---NVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKL 431
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 64.7 bits (156), Expect = 9e-11
Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)
Query: 43 RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
RR +ALI + +F LP R G D + R LG+ V +L A ++ +
Sbjct: 204 RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 260
Query: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155
+ H +D V +SHG EG A+ K + T+ +F C SL KP
Sbjct: 261 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 320
Query: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209
K+ I+QACRG +H D P L ++ +Q+ + ++A SV + DF+
Sbjct: 321 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 373
Query: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269
S S R+ GS +I +L KY E+ V + + P A
Sbjct: 374 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 425
Query: 270 IGKKQVPCF-ASMLTKKLHFFP 290
K Q+P + LT+ + FP
Sbjct: 426 --KAQMPTIERATLTRDFYLFP 445
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 64.7 bits (156), Expect = 9e-11
Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)
Query: 43 RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
RR +ALI + +F LP R G D + R LG+ V +L A ++ +
Sbjct: 49 RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 105
Query: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155
+ H +D V +SHG EG A+ K + T+ +F C SL KP
Sbjct: 106 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 165
Query: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209
K+ I+QACRG +H D P L ++ +Q+ + ++A SV + DF+
Sbjct: 166 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 218
Query: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269
S S R+ GS +I +L KY E+ V + + P A
Sbjct: 219 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 270
Query: 270 IGKKQVPCF-ASMLTKKLHFFP 290
K Q+P + LT+ + FP
Sbjct: 271 --KAQMPTIERATLTRDFYLFP 290
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 64.7 bits (156), Expect = 9e-11
Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)
Query: 43 RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
RR +ALI + +F LP R G D + R LG+ V +L A ++ +
Sbjct: 133 RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 189
Query: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155
+ H +D V +SHG EG A+ K + T+ +F C SL KP
Sbjct: 190 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 249
Query: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209
K+ I+QACRG +H D P L ++ +Q+ + ++A SV + DF+
Sbjct: 250 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 302
Query: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269
S S R+ GS +I +L KY E+ V + + P A
Sbjct: 303 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 354
Query: 270 IGKKQVPCF-ASMLTKKLHFFP 290
K Q+P + LT+ + FP
Sbjct: 355 --KAQMPTIERATLTRDFYLFP 374
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 64.7 bits (156), Expect = 9e-11
Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)
Query: 43 RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
RR +ALI + +F LP R G D + R LG+ V +L A ++ +
Sbjct: 191 RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 247
Query: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155
+ H +D V +SHG EG A+ K + T+ +F C SL KP
Sbjct: 248 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 307
Query: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209
K+ I+QACRG +H D P L ++ +Q+ + ++A SV + DF+
Sbjct: 308 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 360
Query: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269
S S R+ GS +I +L KY E+ V + + P A
Sbjct: 361 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 412
Query: 270 IGKKQVPCF-ASMLTKKLHFFP 290
K Q+P + LT+ + FP
Sbjct: 413 --KAQMPTIERATLTRDFYLFP 432
>gi|15718702 caspase 7 isoform beta [Homo sapiens]
Length = 253
Score = 61.6 bits (148), Expect = 8e-10
Identities = 31/93 (33%), Positives = 48/93 (51%)
Query: 33 PAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLK 92
P +Y M+ + G +I N++ F + R GT D + L + F LGF+V +ND
Sbjct: 56 PTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS 115
Query: 93 AEELLLKIHEVSTVSHADADCFVCVFLSHGEGN 125
++ + + S H +A CF C+ LSHGE N
Sbjct: 116 CAKMQDLLKKASEEDHTNAACFACILLSHGEEN 148
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,020,129
Number of Sequences: 37866
Number of extensions: 473511
Number of successful extensions: 829
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 739
Number of HSP's gapped (non-prelim): 39
length of query: 293
length of database: 18,247,518
effective HSP length: 101
effective length of query: 192
effective length of database: 14,423,052
effective search space: 2769225984
effective search space used: 2769225984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.