Guide to the Human Genome
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Search of human proteins with 14916483

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14916483 caspase 6 isoform alpha preproprotein [Homo
sapiens]
         (293 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]      608   e-174
gi|14916485 caspase 6 isoform beta [Homo sapiens]                     396   e-110
gi|14790115 caspase 3 preproprotein [Homo sapiens]                    204   1e-52
gi|14790119 caspase 3 preproprotein [Homo sapiens]                    204   1e-52
gi|15718698 caspase 7 isoform delta [Homo sapiens]                    184   8e-47
gi|15718700 caspase 7 isoform alpha [Homo sapiens]                    184   8e-47
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]           184   8e-47
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]         132   5e-31
gi|122056476 caspase 8 isoform G precursor [Homo sapiens]             129   2e-30
gi|122056474 caspase 8 isoform C precursor [Homo sapiens]             129   2e-30
gi|15718708 caspase 8 isoform C precursor [Homo sapiens]              129   2e-30
gi|15718706 caspase 8 isoform B precursor [Homo sapiens]              129   2e-30
gi|15718704 caspase 8 isoform A precursor [Homo sapiens]              129   2e-30
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]         126   3e-29
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]      115   6e-26
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]         114   8e-26
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]          110   2e-24
gi|6912286 caspase 14 precursor [Homo sapiens]                         82   4e-16
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap...    71   1e-12
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap...    71   1e-12
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]           65   9e-11
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]           65   9e-11
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]             65   9e-11
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [...    65   9e-11
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [...    65   9e-11
gi|209870079 caspase 5 isoform f precursor [Homo sapiens]              65   9e-11
gi|209870073 caspase 5 isoform c [Homo sapiens]                        65   9e-11
gi|209870071 caspase 5 isoform b precursor [Homo sapiens]              65   9e-11
gi|209870069 caspase 5 isoform a precursor [Homo sapiens]              65   9e-11
gi|15718702 caspase 7 isoform beta [Homo sapiens]                      62   8e-10

>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
          Length = 293

 Score =  608 bits (1567), Expect = e-174
 Identities = 293/293 (100%), Positives = 293/293 (100%)

Query: 1   MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT 60
           MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT
Sbjct: 1   MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT 60

Query: 61  LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS 120
           LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS
Sbjct: 61  LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS 120

Query: 121 HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN 180
           HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN
Sbjct: 121 HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN 180

Query: 181 QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG 240
           QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG
Sbjct: 181 QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG 240

Query: 241 SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN 293
           SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
Sbjct: 241 SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN 293


>gi|14916485 caspase 6 isoform beta [Homo sapiens]
          Length = 204

 Score =  396 bits (1017), Expect = e-110
 Identities = 191/191 (100%), Positives = 191/191 (100%)

Query: 103 VSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQA 162
           VSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQA
Sbjct: 14  VSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQA 73

Query: 163 CRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRET 222
           CRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRET
Sbjct: 74  CRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRET 133

Query: 223 VNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASML 282
           VNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASML
Sbjct: 134 VNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASML 193

Query: 283 TKKLHFFPKSN 293
           TKKLHFFPKSN
Sbjct: 194 TKKLHFFPKSN 204



 Score = 32.7 bits (73), Expect = 0.39
 Identities = 15/25 (60%), Positives = 17/25 (68%)

Query: 1  MSSASGLRRGHPAGGEENMTETDAF 25
          MSSASGLRRGHPA    +  + D F
Sbjct: 1  MSSASGLRRGHPAVSTVSHADADCF 25


>gi|14790115 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  204 bits (518), Expect = 1e-52
 Identities = 105/253 (41%), Positives = 147/253 (58%), Gaps = 13/253 (5%)

Query: 37  YKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEEL 96
           YKMD+   G+ +I N++ F     +  R GT  D  NL   F +L +EV+  NDL  EE+
Sbjct: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96

Query: 97  LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPK 156
           +  + +VS   H+    FVCV LSHGE   I+  +  ++++ +T  F+GD+C SL GKPK
Sbjct: 97  VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156

Query: 157 IFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGY 216
           +FIIQACRG + D  +             +T+    D  + + +P  ADFL  YS A GY
Sbjct: 157 LFIIQACRGTELDCGI-------------ETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203

Query: 217 YSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVP 276
           YS R + +GSW+IQ LC ML +Y   LEF  +LT VNRKV+     F  D +   KKQ+P
Sbjct: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263

Query: 277 CFASMLTKKLHFF 289
           C  SMLTK+L+F+
Sbjct: 264 CIVSMLTKELYFY 276


>gi|14790119 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  204 bits (518), Expect = 1e-52
 Identities = 105/253 (41%), Positives = 147/253 (58%), Gaps = 13/253 (5%)

Query: 37  YKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEEL 96
           YKMD+   G+ +I N++ F     +  R GT  D  NL   F +L +EV+  NDL  EE+
Sbjct: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96

Query: 97  LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPK 156
           +  + +VS   H+    FVCV LSHGE   I+  +  ++++ +T  F+GD+C SL GKPK
Sbjct: 97  VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156

Query: 157 IFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGY 216
           +FIIQACRG + D  +             +T+    D  + + +P  ADFL  YS A GY
Sbjct: 157 LFIIQACRGTELDCGI-------------ETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203

Query: 217 YSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVP 276
           YS R + +GSW+IQ LC ML +Y   LEF  +LT VNRKV+     F  D +   KKQ+P
Sbjct: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263

Query: 277 CFASMLTKKLHFF 289
           C  SMLTK+L+F+
Sbjct: 264 CIVSMLTKELYFY 276


>gi|15718698 caspase 7 isoform delta [Homo sapiens]
          Length = 336

 Score =  184 bits (467), Expect = 8e-47
 Identities = 98/256 (38%), Positives = 140/256 (54%), Gaps = 10/256 (3%)

Query: 33  PAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLK 92
           P  +Y M+  + G  +I N++ F     +  R GT  D + L + F  LGF+V  +ND  
Sbjct: 89  PTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS 148

Query: 93  AEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLV 152
             ++   + + S   H +A CF C+ LSHGE N IY  D    I+ LT  F+GD+C +L+
Sbjct: 149 CAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLL 208

Query: 153 GKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSV 212
            KPK+F IQACRG +          +D+  +     I + DA   Y +P  ADFL  YS 
Sbjct: 209 EKPKLFFIQACRGTE----------LDDGIQADSGPINDTDANPRYKIPVEADFLFAYST 258

Query: 213 AEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGK 272
             GYYS R    GSW++Q LC +L ++G  LE  ++LT VN +V++       DP    K
Sbjct: 259 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 318

Query: 273 KQVPCFASMLTKKLHF 288
           KQ+PC  SMLTK+L+F
Sbjct: 319 KQIPCVVSMLTKELYF 334


>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
          Length = 303

 Score =  184 bits (467), Expect = 8e-47
 Identities = 98/256 (38%), Positives = 140/256 (54%), Gaps = 10/256 (3%)

Query: 33  PAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLK 92
           P  +Y M+  + G  +I N++ F     +  R GT  D + L + F  LGF+V  +ND  
Sbjct: 56  PTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS 115

Query: 93  AEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLV 152
             ++   + + S   H +A CF C+ LSHGE N IY  D    I+ LT  F+GD+C +L+
Sbjct: 116 CAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLL 175

Query: 153 GKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSV 212
            KPK+F IQACRG +          +D+  +     I + DA   Y +P  ADFL  YS 
Sbjct: 176 EKPKLFFIQACRGTE----------LDDGIQADSGPINDTDANPRYKIPVEADFLFAYST 225

Query: 213 AEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGK 272
             GYYS R    GSW++Q LC +L ++G  LE  ++LT VN +V++       DP    K
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 285

Query: 273 KQVPCFASMLTKKLHF 288
           KQ+PC  SMLTK+L+F
Sbjct: 286 KQIPCVVSMLTKELYF 301


>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
          Length = 303

 Score =  184 bits (467), Expect = 8e-47
 Identities = 98/256 (38%), Positives = 140/256 (54%), Gaps = 10/256 (3%)

Query: 33  PAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLK 92
           P  +Y M+  + G  +I N++ F     +  R GT  D + L + F  LGF+V  +ND  
Sbjct: 56  PTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS 115

Query: 93  AEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLV 152
             ++   + + S   H +A CF C+ LSHGE N IY  D    I+ LT  F+GD+C +L+
Sbjct: 116 CAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLL 175

Query: 153 GKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSV 212
            KPK+F IQACRG +          +D+  +     I + DA   Y +P  ADFL  YS 
Sbjct: 176 EKPKLFFIQACRGTE----------LDDGIQADSGPINDTDANPRYKIPVEADFLFAYST 225

Query: 213 AEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGK 272
             GYYS R    GSW++Q LC +L ++G  LE  ++LT VN +V++       DP    K
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 285

Query: 273 KQVPCFASMLTKKLHF 288
           KQ+PC  SMLTK+L+F
Sbjct: 286 KQIPCVVSMLTKELYF 301


>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
          Length = 479

 Score =  132 bits (331), Expect = 5e-31
 Identities = 98/278 (35%), Positives = 140/278 (50%), Gaps = 20/278 (7%)

Query: 14  GGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN 73
           G EE +++TD     E    A  Y+M+   RG+ +I N+  F    +L +R+GT  D + 
Sbjct: 210 GEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEI 266

Query: 74  LTRRFSDLGFEVKCFNDLKAEELLLKIHEVS-TVSHADADCFVCVFLSHGEGNHIYAYD- 131
           L+  F  LGF V   N++   E+ + + +     +HAD DCFV   L+HG    +Y+ D 
Sbjct: 267 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE 326

Query: 132 AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITE 191
           A I I+ +   F   +C  L  KPK+F IQAC+G +   P + ++      E+  T++ +
Sbjct: 327 ALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQ-PSVSIEADALNPEQAPTSLQD 385

Query: 192 VDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLE-FTELLT 250
                  ++PA ADFL+  +   GY S R    GSWYIQ LC  L K     E    +LT
Sbjct: 386 -------SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILT 438

Query: 251 LVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHF 288
            VN  VS RRVD         KKQ+P  A  L KKL F
Sbjct: 439 AVNDDVS-RRVD-----KQGTKKQMPQPAFTLRKKLVF 470


>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
          Length = 538

 Score =  129 bits (325), Expect = 2e-30
 Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)

Query: 37  YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
           Y+M  + RG  LI N+  F           ++ +R GT  D   LT  F +L FE+K  +
Sbjct: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344

Query: 90  DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
           D   E++  +LKI+++  + H++ DCF+C  LSHG+   IY  D  +  I  LT  F G 
Sbjct: 345 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 402

Query: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
           KC SL GKPK+F IQAC+G+  Q  +PV        +T+  +    E+D +S  T  +P 
Sbjct: 403 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 454

Query: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
            ADFL+  +      S+R    G+WYIQ LC+ L  +     +   +LT VN +VS    
Sbjct: 455 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 511

Query: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
              KD      KQ+P     L KKL F
Sbjct: 512 ---KDDKKNMGKQMPQPTFTLRKKLVF 535


>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  129 bits (325), Expect = 2e-30
 Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)

Query: 37  YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
           Y+M  + RG  LI N+  F           ++ +R GT  D   LT  F +L FE+K  +
Sbjct: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270

Query: 90  DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
           D   E++  +LKI+++  + H++ DCF+C  LSHG+   IY  D  +  I  LT  F G 
Sbjct: 271 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328

Query: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
           KC SL GKPK+F IQAC+G+  Q  +PV        +T+  +    E+D +S  T  +P 
Sbjct: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 380

Query: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
            ADFL+  +      S+R    G+WYIQ LC+ L  +     +   +LT VN +VS    
Sbjct: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 437

Query: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
              KD      KQ+P     L KKL F
Sbjct: 438 ---KDDKKNMGKQMPQPTFTLRKKLVF 461


>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  129 bits (325), Expect = 2e-30
 Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)

Query: 37  YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
           Y+M  + RG  LI N+  F           ++ +R GT  D   LT  F +L FE+K  +
Sbjct: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270

Query: 90  DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
           D   E++  +LKI+++  + H++ DCF+C  LSHG+   IY  D  +  I  LT  F G 
Sbjct: 271 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328

Query: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
           KC SL GKPK+F IQAC+G+  Q  +PV        +T+  +    E+D +S  T  +P 
Sbjct: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 380

Query: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
            ADFL+  +      S+R    G+WYIQ LC+ L  +     +   +LT VN +VS    
Sbjct: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 437

Query: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
              KD      KQ+P     L KKL F
Sbjct: 438 ---KDDKKNMGKQMPQPTFTLRKKLVF 461


>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
          Length = 479

 Score =  129 bits (325), Expect = 2e-30
 Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)

Query: 37  YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
           Y+M  + RG  LI N+  F           ++ +R GT  D   LT  F +L FE+K  +
Sbjct: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285

Query: 90  DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
           D   E++  +LKI+++  + H++ DCF+C  LSHG+   IY  D  +  I  LT  F G 
Sbjct: 286 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 343

Query: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
           KC SL GKPK+F IQAC+G+  Q  +PV        +T+  +    E+D +S  T  +P 
Sbjct: 344 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 395

Query: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
            ADFL+  +      S+R    G+WYIQ LC+ L  +     +   +LT VN +VS    
Sbjct: 396 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 452

Query: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
              KD      KQ+P     L KKL F
Sbjct: 453 ---KDDKKNMGKQMPQPTFTLRKKLVF 476


>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
          Length = 496

 Score =  129 bits (325), Expect = 2e-30
 Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)

Query: 37  YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89
           Y+M  + RG  LI N+  F           ++ +R GT  D   LT  F +L FE+K  +
Sbjct: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302

Query: 90  DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146
           D   E++  +LKI+++  + H++ DCF+C  LSHG+   IY  D  +  I  LT  F G 
Sbjct: 303 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 360

Query: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202
           KC SL GKPK+F IQAC+G+  Q  +PV        +T+  +    E+D +S  T  +P 
Sbjct: 361 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 412

Query: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261
            ADFL+  +      S+R    G+WYIQ LC+ L  +     +   +LT VN +VS    
Sbjct: 413 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 469

Query: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288
              KD      KQ+P     L KKL F
Sbjct: 470 ---KDDKKNMGKQMPQPTFTLRKKLVF 493


>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
          Length = 522

 Score =  126 bits (316), Expect = 3e-29
 Identities = 96/278 (34%), Positives = 137/278 (49%), Gaps = 25/278 (8%)

Query: 14  GGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN 73
           G   N   ++   KR     A  Y+M+   RG+ +I N+  F    +L +R+GT  D + 
Sbjct: 258 GASANTLNSETSTKR-----AAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEI 309

Query: 74  LTRRFSDLGFEVKCFNDLKAEELLLKIHEVS-TVSHADADCFVCVFLSHGEGNHIYAYD- 131
           L+  F  LGF V   N++   E+ + + +     +HAD DCFV   L+HG    +Y+ D 
Sbjct: 310 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE 369

Query: 132 AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITE 191
           A I I+ +   F   +C  L  KPK+F IQAC+G +   P + ++      E+  T++ +
Sbjct: 370 ALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQ-PSVSIEADALNPEQAPTSLQD 428

Query: 192 VDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLE-FTELLT 250
                  ++PA ADFL+  +   GY S R    GSWYIQ LC  L K     E    +LT
Sbjct: 429 -------SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILT 481

Query: 251 LVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHF 288
            VN  VS RRVD         KKQ+P  A  L KKL F
Sbjct: 482 AVNDDVS-RRVD-----KQGTKKQMPQPAFTLRKKLVF 513


>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
          Length = 416

 Score =  115 bits (287), Expect = 6e-26
 Identities = 84/265 (31%), Positives = 124/265 (46%), Gaps = 33/265 (12%)

Query: 45  GIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVS 104
           G  LI N+  F     L  R G+  D + L RRFS L F V+   DL A++++L + E++
Sbjct: 161 GHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELA 220

Query: 105 TVSHADADCFVCVFLSHG-EGNH------IYAYD-AKIEIQTLTGLFKGDKCHSLVGKPK 156
              H   DC V V LSHG + +H      +Y  D   + ++ +  +F G  C SL GKPK
Sbjct: 221 QQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPK 280

Query: 157 IFIIQACRGNQHD-----VPVIPLDVVDNQTEKLDT--------NITEVDAASVYTLPAG 203
           +F IQAC G Q D         P D       + D            ++DA S  +LP  
Sbjct: 281 LFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAIS--SLPTP 338

Query: 204 ADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDF 263
           +D  + YS   G+ S R+  +GSWY++ L ++  ++  S +   LL  V   VS + +  
Sbjct: 339 SDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGI-- 396

Query: 264 CKDPSAIGKKQVPCFASMLTKKLHF 288
                    KQ+P   + L KKL F
Sbjct: 397 --------YKQMPGCFNFLRKKLFF 413


>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
          Length = 521

 Score =  114 bits (286), Expect = 8e-26
 Identities = 75/227 (33%), Positives = 114/227 (50%), Gaps = 18/227 (7%)

Query: 14  GGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN 73
           G   N   ++   KR     A  Y+M+   RG+ +I N+  F    +L +R+GT  D + 
Sbjct: 258 GASANTLNSETSTKR-----AAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEI 309

Query: 74  LTRRFSDLGFEVKCFNDLKAEELLLKIHEVS-TVSHADADCFVCVFLSHGEGNHIYAYD- 131
           L+  F  LGF V   N++   E+ + + +     +HAD DCFV   L+HG    +Y+ D 
Sbjct: 310 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE 369

Query: 132 AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITE 191
           A I I+ +   F   +C  L  KPK+F IQAC+G +   P + ++      E+  T++ +
Sbjct: 370 ALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQ-PSVSIEADALNPEQAPTSLQD 428

Query: 192 VDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGK 238
                  ++PA ADFL+  +   GY S R    GSWYIQ LC  L K
Sbjct: 429 -------SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468


>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
          Length = 452

 Score =  110 bits (274), Expect = 2e-24
 Identities = 76/260 (29%), Positives = 118/260 (45%), Gaps = 10/260 (3%)

Query: 37  YKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEEL 96
           Y++  R RG+AL+ ++  F     L  R G   D   L   F  LG++V    D  A+E+
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251

Query: 97  LLKIHEVSTV-SHADADCFVCVFLSHGEGNHIYAYDAKI-EIQTLTGLFKGDKCHSLVGK 154
             K+   + + +H   D  +   LSHG    IY  D K+ ++Q +  LF    C SL  K
Sbjct: 252 QEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNK 311

Query: 155 PKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAAS----VYTLPAGADFLMCY 210
           PK+F IQACRG++ D  V   D  D +         E DA         LP  +D +  Y
Sbjct: 312 PKMFFIQACRGDETDRGV---DQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGY 368

Query: 211 SVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAI 270
           +  +G  + R T  GSWYI+ L ++  +    +   ++L  VN  +  R   +       
Sbjct: 369 ACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDRE-GYAPGTEFH 427

Query: 271 GKKQVPCFASMLTKKLHFFP 290
             K++  + S L + L+ FP
Sbjct: 428 RCKEMSEYCSTLCRHLYLFP 447


>gi|6912286 caspase 14 precursor [Homo sapiens]
          Length = 242

 Score = 82.4 bits (202), Expect = 4e-16
 Identities = 74/257 (28%), Positives = 107/257 (41%), Gaps = 30/257 (11%)

Query: 35  EKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAE 94
           EKY M   R  + L     R           G+  D D L   F  L FE     D  AE
Sbjct: 10  EKYDMSGARLALILCVTKAR----------EGSEEDLDALEHMFRQLRFESTMKRDPTAE 59

Query: 95  EL---LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAK-IEIQTLTGLFKGDKCHS 150
           +    L K  +          C   V ++HG    +   D + ++++ L        C +
Sbjct: 60  QFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQA 119

Query: 151 LVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCY 210
           L  KPK++IIQACRG Q D    P + V          I  V   S  T+P   D L  Y
Sbjct: 120 LRAKPKVYIIQACRGEQRD----PGETVGGD------EIVMVIKDSPQTIPTYTDALHVY 169

Query: 211 SVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAI 270
           S  EGY ++R    GS +IQ L ++  K    +   ELLT V R++++   +  ++  A 
Sbjct: 170 STVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHI--LELLTEVTRRMAE--AELVQEGKA- 224

Query: 271 GKKQVPCFASMLTKKLH 287
            +K  P   S L K+L+
Sbjct: 225 -RKTNPEIQSTLRKRLY 240


>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 62/202 (30%), Positives = 92/202 (45%), Gaps = 26/202 (12%)

Query: 81  LGFEVKCFNDLKAE---ELLLKIHEVSTVSHADADCFVCVFLSHG--EGNHIYAYDAKIE 135
           LGFE     D  A+   E L +  E          C +   ++HG   G  + A   +++
Sbjct: 209 LGFETTVRTDPTAQAFQEELAQFREQLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQ 268

Query: 136 IQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDV------------VDNQTE 183
            + L  + +  +C  L G+PKIF++QACRG   D  V P  +            V +  +
Sbjct: 269 PEAL--MQELSRCQVLQGRPKIFLLQACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHAD 326

Query: 184 KLDTNITEVDAASVYTLPAG----ADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKY 239
            L     E   +S    P G    AD L  YS AEGY ++R+   GS +IQ L E+L + 
Sbjct: 327 VLQI-YAEAQGSSCRGTPPGSSDQADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVL-RA 383

Query: 240 GSSLEFTELLTLVNRKVSQRRV 261
               +  ELLT VNR+V ++ V
Sbjct: 384 NPGRDLLELLTEVNRRVCEQEV 405


>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 62/202 (30%), Positives = 92/202 (45%), Gaps = 26/202 (12%)

Query: 81  LGFEVKCFNDLKAE---ELLLKIHEVSTVSHADADCFVCVFLSHG--EGNHIYAYDAKIE 135
           LGFE     D  A+   E L +  E          C +   ++HG   G  + A   +++
Sbjct: 209 LGFETTVRTDPTAQAFQEELAQFREQLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQ 268

Query: 136 IQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDV------------VDNQTE 183
            + L  + +  +C  L G+PKIF++QACRG   D  V P  +            V +  +
Sbjct: 269 PEAL--MQELSRCQVLQGRPKIFLLQACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHAD 326

Query: 184 KLDTNITEVDAASVYTLPAG----ADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKY 239
            L     E   +S    P G    AD L  YS AEGY ++R+   GS +IQ L E+L + 
Sbjct: 327 VLQI-YAEAQGSSCRGTPPGSSDQADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVL-RA 383

Query: 240 GSSLEFTELLTLVNRKVSQRRV 261
               +  ELLT VNR+V ++ V
Sbjct: 384 NPGRDLLELLTEVNRRVCEQEV 405


>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
          Length = 311

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 70/256 (27%), Positives = 108/256 (42%), Gaps = 22/256 (8%)

Query: 43  RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
           R  +ALI  +E F    ++P R G   D   +T    +LG+ V    +L A ++  ++  
Sbjct: 68  RTRLALIICNEEFD---SIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEA 124

Query: 103 VS-TVSHADADCFVCVFLSHG--EG----NHIYAYDAKIEIQTLTGLFKGDKCHSLVGKP 155
            +    H  +D    VF+SHG  EG     H       +++  +  +     C SL  KP
Sbjct: 125 FAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 184

Query: 156 KIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEG 215
           K+ IIQACRG+   V      V  +    L T   E +  ++       DF+   S    
Sbjct: 185 KVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTT-EEFEDDAIKKAHIEKDFIAFCSSTPD 243

Query: 216 YYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV 275
             S R    GS +I  L E + +Y  S +  E+     RKV   R  F + P   G+ Q+
Sbjct: 244 NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKV---RFSF-EQPD--GRAQM 293

Query: 276 PCFASM-LTKKLHFFP 290
           P    + LT+  + FP
Sbjct: 294 PTTERVTLTRCFYLFP 309


>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
          Length = 404

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 70/256 (27%), Positives = 108/256 (42%), Gaps = 22/256 (8%)

Query: 43  RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
           R  +ALI  +E F    ++P R G   D   +T    +LG+ V    +L A ++  ++  
Sbjct: 161 RTRLALIICNEEFD---SIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEA 217

Query: 103 VS-TVSHADADCFVCVFLSHG--EG----NHIYAYDAKIEIQTLTGLFKGDKCHSLVGKP 155
            +    H  +D    VF+SHG  EG     H       +++  +  +     C SL  KP
Sbjct: 218 FAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 277

Query: 156 KIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEG 215
           K+ IIQACRG+   V      V  +    L T   E +  ++       DF+   S    
Sbjct: 278 KVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTT-EEFEDDAIKKAHIEKDFIAFCSSTPD 336

Query: 216 YYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV 275
             S R    GS +I  L E + +Y  S +  E+     RKV   R  F + P   G+ Q+
Sbjct: 337 NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKV---RFSF-EQPD--GRAQM 386

Query: 276 PCFASM-LTKKLHFFP 290
           P    + LT+  + FP
Sbjct: 387 PTTERVTLTRCFYLFP 402


>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
          Length = 383

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 70/256 (27%), Positives = 108/256 (42%), Gaps = 22/256 (8%)

Query: 43  RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
           R  +ALI  +E F    ++P R G   D   +T    +LG+ V    +L A ++  ++  
Sbjct: 140 RTRLALIICNEEFD---SIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEA 196

Query: 103 VS-TVSHADADCFVCVFLSHG--EG----NHIYAYDAKIEIQTLTGLFKGDKCHSLVGKP 155
            +    H  +D    VF+SHG  EG     H       +++  +  +     C SL  KP
Sbjct: 197 FAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 256

Query: 156 KIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEG 215
           K+ IIQACRG+   V      V  +    L T   E +  ++       DF+   S    
Sbjct: 257 KVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTT-EEFEDDAIKKAHIEKDFIAFCSSTPD 315

Query: 216 YYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV 275
             S R    GS +I  L E + +Y  S +  E+     RKV   R  F + P   G+ Q+
Sbjct: 316 NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKV---RFSF-EQPD--GRAQM 365

Query: 276 PCFASM-LTKKLHFFP 290
           P    + LT+  + FP
Sbjct: 366 PTTERVTLTRCFYLFP 381


>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 62/235 (26%), Positives = 100/235 (42%), Gaps = 42/235 (17%)

Query: 16  EENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN-- 73
           ++++ E++AF  + +  P E+YKM  +  GI LI +                C   +   
Sbjct: 225 KKSIQESEAFLPQSI--PEERYKMKSKPLGICLIID----------------CIGNETEL 266

Query: 74  LTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTV--------SHADADCFVCVFLSHGEGN 125
           L   F+ LG+EV+ F       L L +H +S +         H D D FVCV +S G   
Sbjct: 267 LRDTFTSLGYEVQKF-------LHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQ 319

Query: 126 HIYAYD---AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQT 182
            +Y  D   + + +  +  +F GD C  L GKPK+F IQ    ++  +    L  VD   
Sbjct: 320 SVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPA 379

Query: 183 EKLDTNIT-EVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML 236
            K   N+  +     + T+   ADF      A+     +   + S Y+Q L + L
Sbjct: 380 MK---NVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKL 431


>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 62/235 (26%), Positives = 100/235 (42%), Gaps = 42/235 (17%)

Query: 16  EENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN-- 73
           ++++ E++AF  + +  P E+YKM  +  GI LI +                C   +   
Sbjct: 225 KKSIQESEAFLPQSI--PEERYKMKSKPLGICLIID----------------CIGNETEL 266

Query: 74  LTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTV--------SHADADCFVCVFLSHGEGN 125
           L   F+ LG+EV+ F       L L +H +S +         H D D FVCV +S G   
Sbjct: 267 LRDTFTSLGYEVQKF-------LHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQ 319

Query: 126 HIYAYD---AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQT 182
            +Y  D   + + +  +  +F GD C  L GKPK+F IQ    ++  +    L  VD   
Sbjct: 320 SVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPA 379

Query: 183 EKLDTNIT-EVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML 236
            K   N+  +     + T+   ADF      A+     +   + S Y+Q L + L
Sbjct: 380 MK---NVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKL 431


>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
          Length = 447

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)

Query: 43  RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
           RR +ALI  + +F     LP R G   D   + R    LG+ V    +L A ++   +  
Sbjct: 204 RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 260

Query: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155
            +    H  +D    V +SHG  EG    A+  K    +   T+  +F    C SL  KP
Sbjct: 261 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 320

Query: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209
           K+ I+QACRG +H      D P   L ++ +Q+ +       ++A SV  +    DF+  
Sbjct: 321 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 373

Query: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269
            S      S R+   GS +I +L     KY       E+   V +          + P A
Sbjct: 374 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 425

Query: 270 IGKKQVPCF-ASMLTKKLHFFP 290
             K Q+P    + LT+  + FP
Sbjct: 426 --KAQMPTIERATLTRDFYLFP 445


>gi|209870073 caspase 5 isoform c [Homo sapiens]
          Length = 292

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)

Query: 43  RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
           RR +ALI  + +F     LP R G   D   + R    LG+ V    +L A ++   +  
Sbjct: 49  RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 105

Query: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155
            +    H  +D    V +SHG  EG    A+  K    +   T+  +F    C SL  KP
Sbjct: 106 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 165

Query: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209
           K+ I+QACRG +H      D P   L ++ +Q+ +       ++A SV  +    DF+  
Sbjct: 166 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 218

Query: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269
            S      S R+   GS +I +L     KY       E+   V +          + P A
Sbjct: 219 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 270

Query: 270 IGKKQVPCF-ASMLTKKLHFFP 290
             K Q+P    + LT+  + FP
Sbjct: 271 --KAQMPTIERATLTRDFYLFP 290


>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
          Length = 376

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)

Query: 43  RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
           RR +ALI  + +F     LP R G   D   + R    LG+ V    +L A ++   +  
Sbjct: 133 RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 189

Query: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155
            +    H  +D    V +SHG  EG    A+  K    +   T+  +F    C SL  KP
Sbjct: 190 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 249

Query: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209
           K+ I+QACRG +H      D P   L ++ +Q+ +       ++A SV  +    DF+  
Sbjct: 250 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 302

Query: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269
            S      S R+   GS +I +L     KY       E+   V +          + P A
Sbjct: 303 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 354

Query: 270 IGKKQVPCF-ASMLTKKLHFFP 290
             K Q+P    + LT+  + FP
Sbjct: 355 --KAQMPTIERATLTRDFYLFP 374


>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
          Length = 434

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)

Query: 43  RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
           RR +ALI  + +F     LP R G   D   + R    LG+ V    +L A ++   +  
Sbjct: 191 RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 247

Query: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155
            +    H  +D    V +SHG  EG    A+  K    +   T+  +F    C SL  KP
Sbjct: 248 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 307

Query: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209
           K+ I+QACRG +H      D P   L ++ +Q+ +       ++A SV  +    DF+  
Sbjct: 308 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 360

Query: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269
            S      S R+   GS +I +L     KY       E+   V +          + P A
Sbjct: 361 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 412

Query: 270 IGKKQVPCF-ASMLTKKLHFFP 290
             K Q+P    + LT+  + FP
Sbjct: 413 --KAQMPTIERATLTRDFYLFP 432


>gi|15718702 caspase 7 isoform beta [Homo sapiens]
          Length = 253

 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 31/93 (33%), Positives = 48/93 (51%)

Query: 33  PAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLK 92
           P  +Y M+  + G  +I N++ F     +  R GT  D + L + F  LGF+V  +ND  
Sbjct: 56  PTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS 115

Query: 93  AEELLLKIHEVSTVSHADADCFVCVFLSHGEGN 125
             ++   + + S   H +A CF C+ LSHGE N
Sbjct: 116 CAKMQDLLKKASEEDHTNAACFACILLSHGEEN 148


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,020,129
Number of Sequences: 37866
Number of extensions: 473511
Number of successful extensions: 829
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 739
Number of HSP's gapped (non-prelim): 39
length of query: 293
length of database: 18,247,518
effective HSP length: 101
effective length of query: 192
effective length of database: 14,423,052
effective search space: 2769225984
effective search space used: 2769225984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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