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Search of human proteins with 148839339
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
(675 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148839339 nexilin (F actin binding protein) [Homo sapiens] 1322 0.0
gi|148746195 trichohyalin [Homo sapiens] 151 2e-36
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 132 8e-31
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 122 1e-27
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 119 1e-26
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 118 2e-26
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 103 4e-22
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 103 5e-22
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 103 5e-22
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 103 5e-22
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 103 5e-22
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 103 5e-22
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 103 5e-22
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 103 5e-22
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 103 5e-22
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 102 2e-21
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 100 7e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 98 2e-20
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 98 2e-20
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 98 2e-20
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 98 2e-20
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 97 6e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 96 8e-20
gi|221219020 NYD-SP11 protein [Homo sapiens] 95 2e-19
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 95 2e-19
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 92 1e-18
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens] 92 1e-18
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens] 92 2e-18
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 91 5e-18
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 91 5e-18
>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
Length = 675
Score = 1322 bits (3421), Expect = 0.0
Identities = 675/675 (100%), Positives = 675/675 (100%)
Query: 1 MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQ 60
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQ
Sbjct: 1 MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQ 60
Query: 61 YIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKR 120
YIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKR
Sbjct: 61 YIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKR 120
Query: 121 TEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYK 180
TEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYK
Sbjct: 121 TEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYK 180
Query: 181 TSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKE 240
TSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKE
Sbjct: 181 TSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKE 240
Query: 241 SLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAK 300
SLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAK
Sbjct: 241 SLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAK 300
Query: 301 IFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEM 360
IFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEM
Sbjct: 301 IFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEM 360
Query: 361 YKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEE 420
YKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEE
Sbjct: 361 YKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEE 420
Query: 421 ENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLE 480
ENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLE
Sbjct: 421 ENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLE 480
Query: 481 IKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRM 540
IKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRM
Sbjct: 481 IKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRM 540
Query: 541 QFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVR 600
QFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVR
Sbjct: 541 QFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVR 600
Query: 601 FTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNK 660
FTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNK
Sbjct: 601 FTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNK 660
Query: 661 GSAASTCILTIESKN 675
GSAASTCILTIESKN
Sbjct: 661 GSAASTCILTIESKN 675
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 151 bits (381), Expect = 2e-36
Identities = 166/659 (25%), Positives = 303/659 (45%), Gaps = 110/659 (16%)
Query: 23 VPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQ-RRKEQYIREREWNRRKQEIK------ 75
V +L + + +++ + EER Q+ + E+Q R++Q +R + RR+Q +K
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Query: 76 ----------------EMLASDDEEDVSSKVEKAYVPK----LTGTVKGRFAEM--EKQR 113
+ LA +++E ++ K+ +PK L R +++ ++
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERI-KSRIPKWQWQLESEADARQSKVYSRPRK 725
Query: 114 QEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGT-----ESASEEGDDS 168
QE QR+R E+E KRR + L+ + + E A R +Q E+ T E SE G
Sbjct: 726 QEGQRRRQEQEEKRRRRESELQWQ--EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783
Query: 169 LLITVVPVKSYK-------TSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKE 221
L P++ + + ++ F E+E+E++ R + E +K +++ E+ L+
Sbjct: 784 LSAR-PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842
Query: 222 AKCLSLVMDDE------IESEAKKESLSPGKLKLTFEE---------------LERQRQE 260
+ + ++E E +E K + EE E+ R+E
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902
Query: 261 NRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQ 320
+ Q EEE +R E EKR +E RQ E++ Q+ ++ + R + + +E ERQ
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR---QERERQ 959
Query: 321 RREDEKRKAEE--------EARRRIEEEKK-----AFAEARRNMVVDDDSPEMYKTISQE 367
R+D+K + +E E RRR E EKK + ++ ++ + ++
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019
Query: 368 FLTPGKLEINFEELLKQKMEEEKRRTEE-ERKHKLEMEKQEFEQLRQEMGEEEEENETFG 426
+ +L+ E+LL++ E EKRR +E ER+++ E E Q+ E+ Q +GEE E
Sbjct: 1020 YRKKDELQQEEEQLLRE--EREKRRLQERERQYREEEELQQEEE--QLLGEERETRRRQE 1075
Query: 427 LSREY---EELIKLKRSGSIQAKNLKSKFEKIGQL-SEKEIQKK----IEEERARRRAID 478
L R+Y EEL + + + + + E+ Q E+E+Q++ + EER +RR +
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQE 1135
Query: 479 LEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLL 538
LE + RE E +E++ +R E P K R +++ + EEE+ + EE++LL
Sbjct: 1136 LERQYREEEEVQQEEEQLLR-----EEP------EKRRRQELERQYREEEELQQEEEQLL 1184
Query: 539 RMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSE 597
R + E+R +++R+ EEEE +E RS W +P K +V D++
Sbjct: 1185 REEQEKRR----QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239
Score = 147 bits (370), Expect = 4e-35
Identities = 149/601 (24%), Positives = 287/601 (47%), Gaps = 59/601 (9%)
Query: 32 KDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWN----RRKQEIKEMLASDDEEDVS 87
+ + A RE+R ++ +E+Q+R+++++ E E R+++E ++ L +EE+
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840
Query: 88 SKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRK------RTEEERKRRIEQDMLEKRKIQR 141
+ E+A +L G + E++R +EQR+ + EEERKRR + K +Q
Sbjct: 841 QRRERAQ--QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR-RHTLYAKPALQE 897
Query: 142 ELAKRA----EQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKERE 197
+L K E+ E++ E + + + Y+ ++++ E L +E
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQE---------RQYREEEQLQQEEEQLLREER 948
Query: 198 EKERIK-----YEEDKRIRYEEQR-----PSLKEAKCLSLVMDDEIESEAKKESL-SPGK 246
EK R + Y +DK+++ +E++ P + + +E E + ++E L +
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 247 LKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYR 306
K +E ERQ ++ + Q EEE R E EKR +E RQ E+E Q+ ++ R
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 307 PGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQ 366
+ + +E+ERQ R++E+ + EEE R E EK+ E R +++ + +
Sbjct: 1069 ETRRR---QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE----EE 1121
Query: 367 EFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEE-ENETF 425
+ L + + +EL +Q EEE+ + EEE+ + E EK+ ++L ++ EEEE + E
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Query: 426 GLSREYEELIKLKRSGS------IQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDL 479
L RE +E + +R +Q + K ++ Q S+ + Q + E+E A R +
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDN-KV 1240
Query: 480 EIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLR 539
K RE E F + +D +R R+S+ H + EQ + RE+E +RR +++
Sbjct: 1241 YCKGRENEQFRQLEDSQLRD-RQSQQDLQHLLG-----EQQERDREQE-RRRWQQRDRHF 1293
Query: 540 MQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPV 599
+ EQ E + + KR + + +E + E++ + + F++ + + +P+
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 600 R 600
R
Sbjct: 1354 R 1354
Score = 144 bits (363), Expect = 3e-34
Identities = 150/603 (24%), Positives = 278/603 (46%), Gaps = 67/603 (11%)
Query: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRE 64
S++ LS+ P+ + +L + + + + EE+ QRR + ++ ++ Q++ E
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 65 REWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE 124
E +R++ +++ +EED + ++ R E++R ++ R + EEE
Sbjct: 837 EEQLQRRERAQQL---QEEEDGLQEDQE------------RRRSQEQRRDQKWRWQLEEE 881
Query: 125 RKRRIEQDMLEKRKIQRELAKR----AEQIEDINNTGTESASEEGDDSLLITVVPVKSYK 180
RKRR + K +Q +L K E+ E++ E + + + Y+
Sbjct: 882 RKRR-RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE---------RQYR 931
Query: 181 TSGKMKKNFEDLEKEREEKER-----IKYEEDKRIRYEEQR-----PSLKEAKCLSLVMD 230
++++ E L +E EK R +Y +DK+++ +E++ P + +
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 231 DEIESEAKKES-LSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMV 289
+E E + ++E L + K +E ERQ ++ + Q EEE R E EKR +E RQ
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR 1051
Query: 290 NEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARR 349
E+E Q+ ++ R + + +E+ERQ R++E+ + EEE R E EK+ E R
Sbjct: 1052 EEEELQQEEEQLLGEERETRRR---QELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Query: 350 NMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFE 409
+++ + ++ L + + +EL +Q EEE+ + EEE+ + E EK+ +
Sbjct: 1109 QCREEEELQQE----EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ 1164
Query: 410 QLRQEMGEEEE-ENETFGLSREYEELIKLKR------SGSIQAKNLKSKFEKIGQLSEKE 462
+L ++ EEEE + E L RE +E + +R +Q + K ++ Q S+ +
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 463 IQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTH---------KVNM 513
Q + E+E A R + K RE E F + +D +R R+S+ H +
Sbjct: 1225 WQWEPEKENAVRDN-KVYCKGRENEQFRQLEDSQLRD-RQSQQDLQHLLGEQQERDREQE 1282
Query: 514 KARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAED 573
+ R++Q + EEEQ EEQK + + R+ Q REE EE+ +
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRR--DRKSQEEKQLLREEREEKRRRQETDRKFRE 1340
Query: 574 EEQ 576
EEQ
Sbjct: 1341 EEQ 1343
Score = 141 bits (356), Expect = 2e-33
Identities = 138/553 (24%), Positives = 252/553 (45%), Gaps = 53/553 (9%)
Query: 36 EAMQRAREERNQRRSRDEKQRRKEQYIRE-REWNRRKQEI------KEMLASDDEEDVSS 88
E Q REE+ + + RD K + ++Q +RE RE RR+QE +E L + EE
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 89 KVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAE 148
+ E+ +F E E + QE+ RK EEE++ R ++ E++ ++ E R +
Sbjct: 1355 RQER----------DRKFREEELRHQEQGRKFLEEEQRLRRQER--ERKFLKEEQQLRCQ 1402
Query: 149 QIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDK 208
+ E + E + L + K E+ + R+E+ER EE++
Sbjct: 1403 EREQQLRQDRDRKFREEEQQLS---------RQERDRKFREEEQQVRRQERERKFLEEEQ 1453
Query: 209 RIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEE 268
++R E R +E + L + ++ + + + +L +E +R+ +E + E
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP 1513
Query: 269 EARKRLEEEKRAFEEAR-RQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKR 327
E RK LEEE++ + R R+ + E+++ + + + + K EE RQ RE+++
Sbjct: 1514 E-RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQL 1572
Query: 328 KAEEEARR-RIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKM 386
+E R+ R+EE+K E R + D+ + Q + E+LL+++
Sbjct: 1573 SRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE 1632
Query: 387 EEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAK 446
E++ R E +RK +E QLR++ E++ ++ RE E+L++ ++ +
Sbjct: 1633 EQQLHRQERDRKFL-----EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ 1687
Query: 447 NLKSKF-EKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEA 505
KF E+ QL +E ++K +E + R +LE K RE E +E + +
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE--------- 1738
Query: 506 PFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSI 565
R E+ K EEE+ R E++ LR Q R+ Q ++E EE++ S
Sbjct: 1739 -------QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791
Query: 566 MNGSTAEDEEQTR 578
+ +EEQ R
Sbjct: 1792 ESDRKFREEEQLR 1804
Score = 140 bits (354), Expect = 3e-33
Identities = 139/597 (23%), Positives = 272/597 (45%), Gaps = 62/597 (10%)
Query: 36 EAMQRAREERNQRRSRDEKQ---RRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
E Q+ R ER R ++E++ R++E +R+ E +++E + +EE+ K+E+
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIED 152
+ + E +++ Q++QR R E++ +R+ E++ E+++ +RE +R EQ E+
Sbjct: 284 QELRR----------ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 153 INNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRY 212
EE + L E E+ RE++ R + EE++R +
Sbjct: 334 RREQQLRREQEERREQQL-----------------RREQEEERREQQLRREQEEERREQQ 376
Query: 213 EEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARK 272
+ L+ + L E + ++E + +L E+ R+ Q+ R++Q EE +
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436
Query: 273 RLEEEKRAFEEARRQMVNED--EENQDTAKIFKGYRPGKLKLSFEEMERQR----REDEK 326
+ E+E+R R Q D + ++T + + R +LK EE R+R E+E+
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 327 RKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKM 386
R+ +E +++ E++ E R + ++ + + + E + E E+LLK+
Sbjct: 497 REQQERREQQLRREQEERREQR--LKRQEEEERLQQRLRSEQQLRREQEERREQLLKR-- 552
Query: 387 EEEKRRTEEERKHKLEME---------KQEFEQLRQEMGEEEEENETFGLSREYEELIKL 437
EEEKR +E R+ +L+ E K+E E+ +Q + E+EE L RE E ++
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612
Query: 438 KRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDV 497
+ + K + + E+ QL + E Q++ +++ RR E +E+ + EE+ ++
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE--QQERREQRLKREEEEERLEQ 670
Query: 498 RPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFE-QREIDAALQKKRE 556
R R+ E + R EQ E+E+ R + ++ + Q++ + E DA K
Sbjct: 671 RLKREHE---------EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 557 EEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVR-FTVKVTGEPKPE 612
++EG E + S W ++ + + E R FT + E K E
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Score = 135 bits (339), Expect = 2e-31
Identities = 144/601 (23%), Positives = 280/601 (46%), Gaps = 72/601 (11%)
Query: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNR-RKQEIKEMLASDDEEDV 86
K + + + + ++R +EER R+E+ R EQ R+++ R +++E +E +EE+
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 87 SSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQ-RKRTEEERKRRIEQDMLEKRKIQRELAK 145
+ E+ + R +++Q +EE+ ++R E++ R EQ+ ++ ++RE K
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556
Query: 146 RAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYE 205
R EQ + + EE D LL + + + ++ E K REE ER++ E
Sbjct: 557 RLEQ--ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK-REEVERLEQE 613
Query: 206 E--DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRK 263
E ++R++ EE ++ S ++ + + ++E + +L EE E +R E R
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE-EEERLEQRL 672
Query: 264 KQAEEEARKRLEEEKRAFEEARRQMVN---------EDEENQDTAKIFKGYR--PGKLKL 312
K+ EE R+ E + E+AR ++ + E E + +K++ R G+ +
Sbjct: 673 KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732
Query: 313 SFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDS----------PEMYK 362
+E +R+RRE E + EEE R ++E++ + ++ S P + +
Sbjct: 733 QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792
Query: 363 TISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEEN 422
++ + + L +++ +E++RR ER+ +L+ ++E + R+E ++ +E
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852
Query: 423 ETFGLSREYE-----------------ELIKLKRSGSIQAK-NLKSKFEKIGQLSEKEIQ 464
E GL + E E + +R ++ AK L+ + K QL ++E +
Sbjct: 853 ED-GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911
Query: 465 KKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPAR--------------------KSE 504
+ EER +RR + E + RE E +E++ +R R K E
Sbjct: 912 ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971
Query: 505 APFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQR---EIDAALQKKREEEEEE 561
+ + R E+ K REEEE ++ EE++LLR + E+R E + +KK E ++EE
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQ-EEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 562 E 562
E
Sbjct: 1031 E 1031
Score = 133 bits (334), Expect = 6e-31
Identities = 138/592 (23%), Positives = 275/592 (46%), Gaps = 92/592 (15%)
Query: 32 KDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVE 91
+++ E ++ E R Q+ R++++RR++Q RE+E RR+Q+++ + E + +
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 92 KAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIE 151
+ + + E+Q + EQ+ R E++ +R EQ + +++++RE R EQ E
Sbjct: 382 QLR--------REQQLRREQQLRREQQLRREQQLRR--EQQLRREQQLRREQQLRREQEE 431
Query: 152 DINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF--EDLEKEREEKERIKYEEDKR 209
+ + E E + K + ++++ + E ER E+ER K ++ KR
Sbjct: 432 ERHEQKHEQERRE------------QRLKREQEERRDWLKREEETERHEQERRK-QQLKR 478
Query: 210 IRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEE 269
+ EE+R ++E E ++E + +L E+ ER+ Q ++++ EE
Sbjct: 479 DQEEERRERWL-----------KLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527
Query: 270 ARKRLEEE---KRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQ--RRED 324
++RL E +R EE R Q++ +EE ++ + R +LK EE Q +RE+
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEK----RLEQERREQRLKREQEERRDQLLKREE 583
Query: 325 E------KRKAEEEARRRI--EEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEI 376
E KR+ EE +R+ EE ++ E RR + + PE + Q+ L + E
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER--RQQLLKSEEQEE 641
Query: 377 NFEELLKQKMEEE-----KRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREY 431
++ L+++ +E KR EEER + + E E+ QE+ EEE+E R
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ---ARERIK 698
Query: 432 EELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHE 491
+ K + +A +SK + E + +++ +EE+ RRR +L+ +E E + +
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 492 EDD----------------------VDVRPARKSEAPFTHKVNMKARFEQ--MAKAREEE 527
+++ + RP + + + + + EQ + + E+E
Sbjct: 759 QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE 818
Query: 528 EQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRS 579
++RR ++ +QF + E +++ ++ +EEE + ED+E+ RS
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ-----EDQERRRS 865
Score = 132 bits (333), Expect = 8e-31
Identities = 115/562 (20%), Positives = 278/562 (49%), Gaps = 31/562 (5%)
Query: 32 KDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDE---EDVSS 88
+++ + ++ REE+ +R+ D K R +EQ ++ERE +++ ++ ++E ++
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR 1374
Query: 89 KVEKAYVPKLTGTVKGRFAEMEKQ---RQEEQRKRTEEERKRRIEQDMLEKRKIQRELAK 145
K + + +F + E+Q ++ EQ+ R + +RK R E+ L +++ R+ +
Sbjct: 1375 KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434
Query: 146 RAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYE 205
+Q+ E + ++ + + ++ ++ + E+ + R+E++R E
Sbjct: 1435 EEQQVR-----RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLE 1489
Query: 206 EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQ 265
E++++R +E+ +E + S + + E ++ + K EE + +RQE +++
Sbjct: 1490 EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549
Query: 266 AEEEARKRLEEEKRAFEEARRQMVNEDEENQ---DTAKIFKGYRPGKL-----KLSFEEM 317
++ RK EEE+ E +Q+ ++ + + + K+ + + K +L +E
Sbjct: 1550 RQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG 1609
Query: 318 ERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEIN 377
++Q R++ RK E+ + E E++ R+ ++ P++ + ++ L + +
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR-DRK 1668
Query: 378 F---EELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEEL 434
F E+LL++ E++ RR E +RK + E ++ ++ ++ +EE++ L R++ E
Sbjct: 1669 FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREE 1728
Query: 435 IKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDD 494
+L++ + + ++ KI L E++++ + EE++ RR+ D K RE E +E +
Sbjct: 1729 EQLRQETEQEQLRRQERYRKI--LEEEQLRPEREEQQLRRQERDR--KFREEEQLRQERE 1784
Query: 495 VDVRPARKSEAPFTHKVNMK-ARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQK 553
+++S+ F + ++ R EQ + ++ + + R EE++L Q E++E ++
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL---QLEEQEQRLRQER 1841
Query: 554 KREEEEEEEGSIMNGSTAEDEE 575
R+ EE+ + S E++E
Sbjct: 1842 DRQYRAEEQFATQEKSRREEQE 1863
Score = 130 bits (328), Expect = 3e-30
Identities = 135/602 (22%), Positives = 280/602 (46%), Gaps = 76/602 (12%)
Query: 36 EAMQRAREERNQR-RSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDE--EDVSSKVEK 92
E +R R+ER ++ R +E Q+ +EQ +RE RR+QE++ ++E ++ + +
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDML--EKRKIQRELAKRAEQI 150
+ ++ ++ E E+ +QEE++ EE+ KRR E++ E+ ++QR+ K+ +
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRD 1216
Query: 151 EDINNTGTESASEEGDDSLLITVVPVKSYKTSG---------KMKKNFEDL--------E 193
ED + E ++++ V K + + +++ +DL E
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE 1276
Query: 194 KEREEKERIKYEEDKRIRYEEQ--RPSLKEAKCLSLVMDDEIE----------------- 234
++RE++ R + D+ EEQ R KEAK +E +
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Query: 235 ---------SEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEAR 285
E +++ L + F E E + QE +K EEE R R +E +R F +
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396
Query: 286 RQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFA 345
+Q+ ++ E Q + +R + +LS +E +R+ RE+E++ +E R+ EE++
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456
Query: 346 EARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEK 405
+ R +++ Q + +++ +E ++ +EEE++ +ER K ++
Sbjct: 1457 QERHRKFREEE---------QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE 1507
Query: 406 QEFEQLRQEMGEEEEENETFGLSREY---EELIKLKRSGSIQAKNLKSKFEKIGQL-SEK 461
++ ++ EEE++ R++ E+ ++ + G + ++ KF + QL E+
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Query: 462 EIQKKIEEERARR-RAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQM 520
E Q+ +ER R+ R + +++ +E E ED+ +R + + R E+
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR---------RQEGQQQLRQERD 1618
Query: 521 AKAREEEE--QRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTR 578
K RE+E+ Q R EEQ+L R + +++ ++ Q +R+E E++ + E+E+ +
Sbjct: 1619 RKFREDEQLLQER-EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677
Query: 579 SG 580
G
Sbjct: 1678 EG 1679
Score = 128 bits (322), Expect = 2e-29
Identities = 148/583 (25%), Positives = 267/583 (45%), Gaps = 73/583 (12%)
Query: 36 EAMQRAREERNQRR-------SRDEKQRRKEQYIRER---EWNRRKQEIKEMLASDDEED 85
E QR R++R ++ + EKQ R EQ R+R E R++QE +E EE+
Sbjct: 132 EPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE 191
Query: 86 VSSKVEKAYVPKLTGTVKGRFAEM----EKQRQEEQRKRTEEERKRRIEQDMLEKRKIQR 141
+ + + R E+ K R+E+Q++R E + + E++ E RK +
Sbjct: 192 QLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRET 251
Query: 142 ELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKE- 200
L K E++++ EE + K ++L +ER+E+E
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQ----------------LRKLERQELRRERQEEEQ 295
Query: 201 ---RIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQ 257
R++ E+ R + EE+R +E + + E +++ + +L E+ ER+
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEER--------REQQERREQQEERREQQLRREQEERR 347
Query: 258 RQENRKKQAEE----EARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLS 313
Q+ R++Q EE + R+ EEE+R + R Q + +++ + ++ R +L+
Sbjct: 348 EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL---RREQQLRRE 404
Query: 314 FE-EMERQRREDEKRKAEEEARRRIEEEK--KAFAEARRNMVVDDDSPEMYKTISQEFLT 370
+ E+Q R +++ + E++ RR EEE+ + + RR + + E + +E T
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464
Query: 371 PGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLR--QEMGEEEEENETFGLS 428
+ ++ LK+ EEE+R ER KLE E++ +Q R Q++ E+EE L
Sbjct: 465 ERHEQERRKQQLKRDQEEERR----ERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 429 REYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAEN 488
R+ EE +R S Q + + E+ QL ++E +K++E+ER +R + + R+
Sbjct: 521 RQEEEERLQQRLRSEQQLR-REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 489 FHEEDDVDVRPARKSEAPF--------THKVNMKARFEQMAKAREEEEQRR-----IEEQ 535
EE+ R R+ E ++ + R EQ K E EE+RR EEQ
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 536 KLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTR 578
+ R Q +RE +++ + EEEEE + E EE+ R
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEE-RLEQRLKREHEEERR 681
Score = 128 bits (321), Expect = 2e-29
Identities = 122/514 (23%), Positives = 241/514 (46%), Gaps = 56/514 (10%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSK 89
D K + E Q R+ER ++ +E+Q R+E++ + RE + QE +E E D
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488
Query: 90 VEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE----RKRRIEQDMLEKRKIQR-ELA 144
E+ + + K F E E + QE +RK EEE R++R + + E+++++R E
Sbjct: 1489 EEEQQLRRQERDRK--FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG 1546
Query: 145 KRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKY 204
++ Q D E +E ++ L + K E+ + R+E+ER
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQL--------SRQERDRKFRLEEQKVRRQEQERKFM 1598
Query: 205 EEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQ-RQENRK 263
E+++++R +E + L++ + D+++ E +++ L + F E E Q R++ R+
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658
Query: 264 KQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRRE 323
+Q + ++ EE++ +E Q + E + + +R + +L +E ER+ +
Sbjct: 1659 QQLRHDRDRKFREEEQLLQEGEEQQLRRQERD-------RKFREEEQQLRRQERERKFLQ 1711
Query: 324 DEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLK 383
+E++ +E R+ EE++ E + + E Y+ I +E E+L
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQL---RRQERYRKILEE-----------EQLRP 1757
Query: 384 QKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEE-EENETFGLSREYEELIKLKRSGS 442
++ E++ RR E +RK + E EQLRQE E++ E+ RE E+L + +
Sbjct: 1758 EREEQQLRRQERDRKFR------EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Query: 443 IQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARK 502
++ + K+ + E+++Q + +E+R R +ER+ + EE +R+
Sbjct: 1812 LRPQQRDGKY----RWEEEQLQLEEQEQRLR--------QERDRQYRAEEQFATQEKSRR 1859
Query: 503 SEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQK 536
E + K R E+ K REE +R+ +E++
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893
Score = 127 bits (318), Expect = 4e-29
Identities = 132/601 (21%), Positives = 271/601 (45%), Gaps = 94/601 (15%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDE-EDVSSKVEKAYVPK 97
+R +E Q R +E Q+ +EQ + E RR+QE++ ++E + ++ + K
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 98 LTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTG 157
+ R E++ Q+E+ + EER++R Q++ + + + E+ + EQ+ +
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL--LREEP 1158
Query: 158 TESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDL-----EKEREEKERIKYEED----- 207
+ +E + + Y+ ++++ E L EK R+E+ER EE+
Sbjct: 1159 EKRRRQELE----------RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Query: 208 ---KRIRYEEQRPSLK---EAKCLSLVMDDEIESEAKK----ESLSPGKLK--------- 248
+R R E+QR LK E + + V D+++ + ++ L +L+
Sbjct: 1209 KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ 1268
Query: 249 -LTFEELERQRQENRKK------------QAEEEARKRLEEEKRAFEEARRQMVNEDEEN 295
L E+ ER R++ R++ Q E E +K + R +E ++ + E EE
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Query: 296 QDTAKIFKGYRPGKLKLSFEEMERQRREDEKRK---------------AEEEARRRIEEE 340
+ + + +R + L E + RR++ RK EEE R R +E
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER 1388
Query: 341 KKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHK 400
++ F + + + + ++ + ++F + +++ +E ++ EEE++ +ER+ K
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKF-REEEQQLSRQERDRKFREEEQQVRRQERERK 1447
Query: 401 LEMEKQEFEQLRQEMGEEEE----ENETFGLSR---------EYEELIKLKRSGSIQAKN 447
E+Q+ Q R EEE E E L R E ++L + +R + +
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE 1507
Query: 448 LKSK------FEKIGQLSEKEIQKKI--EEERARRRAIDLEIKEREAENFHEEDDVDVRP 499
L+S+ E+ QL ++ Q+K EE++ RR+ + ++ F EE+ +R
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE--QLRQ 1565
Query: 500 ARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE 559
R+ + + + K R E+ R+E+E++ +E+++ LR Q Q+++ +K E+E
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE 1625
Query: 560 E 560
+
Sbjct: 1626 Q 1626
Score = 125 bits (315), Expect = 1e-28
Identities = 124/550 (22%), Positives = 262/550 (47%), Gaps = 55/550 (10%)
Query: 43 EERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTV 102
E+R +R+ R+ K ++EQ +R +E R+Q++++ + D + E+ + +
Sbjct: 1380 EQRLRRQERERKFLKEEQQLRCQE---REQQLRQ------DRDRKFREEEQQLSRQERDR 1430
Query: 103 KGRFAEMEKQRQEEQRKRTEEE--------RKRRIEQDMLEKRKIQRELAKRAEQ--IED 152
K R E + +RQE +RK EEE RK R E+ +L++R+ Q+ + ++ +E+
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490
Query: 153 INNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRY 212
+ + + L + P + + E+ + R++++R +E++++R
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLE--------EEQQLHRQQRQRKFLQEEQQLRR 1542
Query: 213 EEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKL--KLTFEELERQRQENRKKQAEEEA 270
+E+ ++ + ++++ E +++ LS + K EE + +RQE +K E+E
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602
Query: 271 RKRLEEEKRAFEEARRQMVNEDE---ENQDTAKIFKGYRPGKL-----KLSFEEMERQRR 322
+ R +E ++ + R + EDE + ++ ++ + R K +L +E E+Q R
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 323 EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELL 382
D RK EE + E E++ R+ ++ ++ + + + ++ +EL
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722
Query: 383 KQKMEEEKRRTEEERKHKLEMEKQ----EFEQLRQEMGEEE-EENETFGLSREYEELIKL 437
++ EEE+ R E E++ E+ E EQLR E E++ E RE E+L +
Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782
Query: 438 KRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDV 497
+ ++++ KF + E++++++ EE++ R + D + + E + EE + +
Sbjct: 1783 REEQQLRSQESDRKFRE-----EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL 1837
Query: 498 RPARKSE--APFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKR 555
R R + A K+R E+ +EEE++RR E ++ LR + +R Q+K
Sbjct: 1838 RQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR------QQKE 1891
Query: 556 EEEEEEEGSI 565
E+ + G I
Sbjct: 1892 EQRHRQVGEI 1901
Score = 123 bits (309), Expect = 5e-28
Identities = 128/594 (21%), Positives = 274/594 (46%), Gaps = 61/594 (10%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKL 98
++ E R Q+ R++++ R+EQ +R + RR+Q+++ E+ + + + +L
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Query: 99 TGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIE-DINNTG 157
+ R + ++ QEE+R + E++RR EQ + +++ +R+ KR E+ E
Sbjct: 414 RREQQLRREQQLRREQEEERHEQKHEQERR-EQRLKREQEERRDWLKREEETERHEQERR 472
Query: 158 TESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEK--ERIKYEEDK-----RI 210
+ + ++ + ++ + + ++ + L +E+EE+ +R+K +E++ R+
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 211 RYEEQRPSLKEAKCLSLVMDDE---IESEAKKESLSPGKLKLTFEELERQ---RQENRKK 264
R E+Q +E + L+ +E +E E +++ L + + + L+R+ RQ+ K+
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592
Query: 265 QAEEEARKRL--EEEKRAFEEARRQ--MVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQ 320
+ EE +RL EE +R +E RR+ + E+ E + ++ K + + E+Q
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 321 RREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEE 380
R +++ K EEE R + K+ E RR + ++ E + + + + ++ E
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712
Query: 381 LLKQ--------KMEEEKRRTEEE---RKHKLEMEKQEFEQLRQEMGEEEEENETFGLSR 429
+Q K E ++RR E+E R+ + E++ QE E+ ++ +EEE+ F
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ-QEEEQRRDFTWQW 771
Query: 430 EYEEL-------------IKLKRSGSIQAKNLKSKFEK-IGQLSEKEIQKKIEEERARRR 475
+ EE ++ +R ++A+ + + ++ + + EKE +++ ER +
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 476 AI-----DLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREE---- 526
L+ +ER + EED + R+ + + E+ K R
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891
Query: 527 ----EEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQ 576
+EQ R E+Q L Q E+ E+ ++KR +E+E ++EEQ
Sbjct: 892 KPALQEQLRKEQQLL---QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942
Score = 107 bits (266), Expect = 5e-23
Identities = 106/457 (23%), Positives = 220/457 (48%), Gaps = 49/457 (10%)
Query: 36 EAMQRAREERNQRRSRDEKQRRKE---QYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
E Q+ R + R+ R+++ R +E +++ E + R+Q ++ L EE + E+
Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL---QEEQQLRRQER 1545
Query: 93 AYVPKLTGTVKGRFAE-MEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIE 151
+ K R E + ++R+E+Q R E +RK R+E+ + +++ +R+ + +Q+
Sbjct: 1546 GQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605
Query: 152 DINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIR 211
G + +E D + ++ ++ + E+ + R+E++R EE+ ++R
Sbjct: 1606 --RQEGQQQLRQERD----------RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653
Query: 212 YEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQ--RQENRKKQAEEE 269
+E+ L+ + ++++ E +++ L + F E E+Q RQE +K +EE
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE 1713
Query: 270 ARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRP--GKLKLSFEEMERQ-RREDEK 326
+ R +E +R F E Q+ E E+ Q + + YR + +L E E+Q RR++
Sbjct: 1714 QQLRRQELERKFRE-EEQLRQETEQEQLRRQ--ERYRKILEEEQLRPEREEQQLRRQERD 1770
Query: 327 RKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKM 386
RK EE + R E E++ + ++ + + QE E+ L+ +
Sbjct: 1771 RKFREEEQLRQEREEQQLRSQESDRKFREE-----EQLRQE---------REEQQLRPQQ 1816
Query: 387 EEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAK 446
+ K R EEE +L++E+QE ++LRQE + E F +E + + Q +
Sbjct: 1817 RDGKYRWEEE---QLQLEEQE-QRLRQERDRQYRAEEQFAT----QEKSRREEQELWQEE 1868
Query: 447 NLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKE 483
K + E+ +L E+ I+++ +EE+ R+ +++ +E
Sbjct: 1869 EQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 80.9 bits (198), Expect = 4e-15
Identities = 81/348 (23%), Positives = 155/348 (44%), Gaps = 52/348 (14%)
Query: 36 EAMQRAREERNQRRSRDEK--QRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKA 93
E Q+ R+ER+++ DE+ Q R+EQ + +E +R+ E + L + E
Sbjct: 1608 EGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ-------- 1659
Query: 94 YVPKLTGTVKGRFAEMEK---QRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQI 150
+L +F E E+ + +E+Q +R E +RK R E+ L +++ +R+ + +Q+
Sbjct: 1660 ---QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716
Query: 151 EDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFED--LEKEREEKERIKYEEDK 208
E + ++ L + + + +K E+ L EREE++ + E D+
Sbjct: 1717 RR-----QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDR 1771
Query: 209 RIRYEEQ-RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAE 267
+ R EEQ R +E + S D + E E+L ++R+E + + +
Sbjct: 1772 KFREEEQLRQEREEQQLRSQESDRKFREE---------------EQLRQEREEQQLRPQQ 1816
Query: 268 EEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKR 327
+ + R EEE+ EE +++ E + R + + F E+ RRE+++
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERD------------RQYRAEEQFATQEKSRREEQEL 1864
Query: 328 -KAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKL 374
+ EE+ RR+ E K RR + ++ + SQE G+L
Sbjct: 1865 WQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRL 1912
Score = 78.2 bits (191), Expect = 2e-14
Identities = 85/395 (21%), Positives = 163/395 (41%), Gaps = 93/395 (23%)
Query: 252 EELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLK 311
+E +++R E R +Q EEE +R +++ +E R++ +E+++ ++ + R +
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKR---QEQERELAEGEEQSEKQERLEQRDRQRR-- 169
Query: 312 LSFEEMERQRRE----DEKRKAEE-------------------------EARRRIEEEKK 342
EE+ RQR+E +E+R EE E RR+ EEK+
Sbjct: 170 --DEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ 227
Query: 343 AFAEARRNMV----------------------VDDDSPEMYKTISQEFLTPGKLE----- 375
R++ V + ++ P+ + + +E KLE
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Query: 376 ------------INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENE 423
+ E+ L++K EEE+R +EER+ + E +Q+ E+ Q++ E+EE
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347
Query: 424 TFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKE 483
L RE EE + + + + + +E Q + E++ R + + E +
Sbjct: 348 EQQLRREQEE------------ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395
Query: 484 REAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFE 543
R + E + + E + ++ E+ ++ E++RR EQ+L R Q E
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR--EQRLKREQEE 453
Query: 544 QREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTR 578
+R+ K+ EE E E D+E+ R
Sbjct: 454 RRD----WLKREEETERHEQERRKQQLKRDQEEER 484
Score = 54.7 bits (130), Expect = 3e-07
Identities = 50/196 (25%), Positives = 92/196 (46%), Gaps = 14/196 (7%)
Query: 386 MEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQA 445
++EEKR + ++ L+ +QE +Q R E + + E E R+ ++ +
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ------KRQEQEREL 148
Query: 446 KNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEA 505
+ + EK +L +++ Q++ EE +R+ E +ERE EE + E
Sbjct: 149 AEGEEQSEKQERLEQRDRQRRDEELWRQRQ----EWQEREERRAEEEQLQSCKGHETEEF 204
Query: 506 PFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQRE---IDAALQKKREEEEEEE 562
P ++ + E K REE++Q+R E Q + + E++E + L+K+ E+ +EEE
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264
Query: 563 GSIMNGSTAEDEEQTR 578
E+EEQ R
Sbjct: 265 PQ-RQRELQEEEEQLR 279
Score = 36.2 bits (82), Expect = 0.10
Identities = 27/103 (26%), Positives = 49/103 (47%), Gaps = 14/103 (13%)
Query: 24 PKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDE 83
P+ G + + E +Q +E+ R+ RD + R +EQ+ + + R +QE+ + E
Sbjct: 1814 PQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQ------E 1867
Query: 84 EDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERK 126
E+ + E+ K R + +Q++EEQR R E K
Sbjct: 1868 EEQKRRQERER--------KLREEHIRRQQKEEQRHRQVGEIK 1902
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 132 bits (333), Expect = 8e-31
Identities = 148/605 (24%), Positives = 272/605 (44%), Gaps = 104/605 (17%)
Query: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKE--QYIREREWN---RRKQEIKEMLASDD 82
+GD + F REER Q+R ++ +R+KE I + + RR Q + +
Sbjct: 89 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 148
Query: 83 EEDVSSKVEKAYVPKLTGTV-----KGRFAEMEKQRQEEQRKRTEEERKRR--------- 128
+E+ S ++ Y + T TV K + + E+ ++E++ K EEE K +
Sbjct: 149 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQV 208
Query: 129 ---IEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKM 185
+E+ E ++ ++ + QI E E+G D + S
Sbjct: 209 EVMVEEKTTESQEETVVMSLKNGQISS-EEPKQEEEREQGSDEI------------SHHE 255
Query: 186 KKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPG 245
K ED E+ E+ R++ EE +RI+ E+ + + D+ EA++++ +
Sbjct: 256 KMEEEDKERAEAERARLEAEERERIKAEQDKK----------IADERARIEAEEKAAAQE 305
Query: 246 KLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGY 305
+ + EE ER R+E +K+A EE ++ EEEKRA EE RQ + E+E+
Sbjct: 306 RERREAEERERMREE--EKRAAEERQRIKEEEKRAAEE--RQRIKEEEKRAAE------- 354
Query: 306 RPGKLKLSFEEMERQR-REDEKRKAEEEARRRIEEEKKA-FAEARRNMVVDDDSPEMYKT 363
ERQR +E+EKR AEE R R EEE+KA E +RN +++ M +T
Sbjct: 355 ------------ERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQET 402
Query: 364 ISQEFLTPGKLEINFEELLKQKMEEEKRRTE------EERKHKLEMEKQEFEQLRQEMGE 417
+ K+E + ++K +E+K +T EE+ K++ ++++ ++ + +
Sbjct: 403 KIKGEKVEQKIEGKWVN--EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460
Query: 418 EEEENETFGLSREYEELIKL------------KRSGSIQAKNLK---SKFEKIG---QLS 459
EE ++E +E +E +K ++G LK + F + G +
Sbjct: 461 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD 520
Query: 460 EKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQ 519
KE + + E +R E++ R E EE + + +K + +K + E+
Sbjct: 521 TKEAEGAPQVEAGKRLE---ELRRRRGETESEEFE---KLKQKQQEAALELEELKKKREE 574
Query: 520 MAKAREEEEQRRIEEQ--KLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQT 577
K EEEEQRR +E+ + LR + E+R + ++++R E E+ + ++D++
Sbjct: 575 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 634
Query: 578 RSGAP 582
+ P
Sbjct: 635 KCFTP 639
Score = 110 bits (276), Expect = 3e-24
Identities = 145/617 (23%), Positives = 276/617 (44%), Gaps = 101/617 (16%)
Query: 30 DVKDKFEAMQRAREERN--------QRRSRDEKQRRKEQYIREREWN-RRKQEIKEMLAS 80
D + + E ++ REE QR DE++ +E+ R R+ R+KQE + +
Sbjct: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
Query: 81 DDEEDVSSKV----EKAYVPKLTGTVKG----RFAEMEKQRQEEQRKRTEEERKRRIEQD 132
D+ +V+++ E+A V+G F E +R+E ++KR +E +R+ E D
Sbjct: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
Query: 133 --------MLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLI--TVVPVKSYKTS 182
L R++Q + A+ T E SE + I T KSY+
Sbjct: 123 PTITDASLSLPSRRMQNDTAEN-------ETTEKEEKSESRQERYEIEETETVTKSYQ-- 173
Query: 183 GKMKKNFEDLEK-EREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKES 241
K ++ D E+ ++E+KE+ + EE+K +R S+ E + +V + ES+ +
Sbjct: 174 ---KNDWRDAEENKKEDKEKEEEEEEK-----PKRGSIGENQVEVMVEEKTTESQEETVV 225
Query: 242 LSPGKLKLTFEELERQRQENRKKQAEEEA--RKRLEEEKRAFEEARRQMVNEDEENQDTA 299
+S +++ EE +QE ++Q +E +++EEE + EA R + +E + A
Sbjct: 226 MSLKNGQISSEE---PKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282
Query: 300 KIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPE 359
+ K + ++ EE + ++ +R+ EE R EEEK+A E +R + + E
Sbjct: 283 EQDKKIADERARIEAEE--KAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAE 340
Query: 360 MYKTISQEFLTPGKLEINFEELLKQKMEEEKR-RTEEERKHKLEMEKQEFE--------- 409
+ I +E + +E K+ EE +R R EEE K K+E +K+ +
Sbjct: 341 ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQ 400
Query: 410 --QLRQEMGEEEEENETFGLSREYEELIK---LKRSGSIQAKNLKSKFEKI--------- 455
+++ E E++ E + + E+ ++ LK+ G + +++K EK+
Sbjct: 401 ETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460
Query: 456 GQLSEKEIQKKIEEERARRRAID-----LEIKEREAE----NFHEEDDVDVRPARKS--- 503
++ +++I+K E + + +D E+K + E ++ RP ++
Sbjct: 461 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD 520
Query: 504 --EAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEE 561
EA +V R E++ + R E E E+ K Q++ +AAL+ + +++ E
Sbjct: 521 TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK-------QKQQEAALELEELKKKRE 573
Query: 562 EGSIMNGSTAEDEEQTR 578
E E+EEQ R
Sbjct: 574 E----RRKVLEEEEQRR 586
Score = 90.9 bits (224), Expect = 3e-18
Identities = 108/460 (23%), Positives = 207/460 (45%), Gaps = 76/460 (16%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSK 89
D + + EA ++A + +RR +E++R +E+ R E +R +E +E A+++ + + +
Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKE-EEKRAAEERQRIKEE 348
Query: 90 VEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKR-RIEQDMLEKRKIQRELAKRAE 148
++A AE E+QR +E+ KR EER+R R E++ EK K++ + KR +
Sbjct: 349 EKRA-------------AE-ERQRIKEEEKRAAEERQRARAEEE--EKAKVEEQ--KRNK 390
Query: 149 QIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERI----KY 204
Q+E+ + E+ +K K K++ + + +K +E+K + K
Sbjct: 391 QLEEKKHAMQET--------------KIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQ 436
Query: 205 EEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKK 264
E+K + + +R L+E K +EI+ E K+ P + +F + ++ E + +
Sbjct: 437 GEEKGTKVQAKREKLQEDK--PTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
Query: 265 QAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRRED 324
E K L+ + F + + +E + ++ G R +L+ E E + E
Sbjct: 495 NGEFMTHK-LKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK 553
Query: 325 EKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQ 384
K+K ++EA +EE KK E R+ V+++ EE ++
Sbjct: 554 LKQK-QQEAALELEELKKKREERRK--VLEE-----------------------EEQRRK 587
Query: 385 KMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQ 444
+ E +++ EEE K +L K+E E+ R E E+ ++ GLS + + GS
Sbjct: 588 QEEADRKLREEEEKRRL---KEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS-- 642
Query: 445 AKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKER 484
K E+ + K +QK + + AI +I R
Sbjct: 643 ----SLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 678
Score = 58.5 bits (140), Expect = 2e-08
Identities = 72/346 (20%), Positives = 146/346 (42%), Gaps = 49/346 (14%)
Query: 252 EELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLK 311
++ ER+R+ R+K+ E RLE E+ A++ D++ ++ A+
Sbjct: 2 DDFERRRELRRQKREE----MRLEAERIAYQR-------NDDDEEEAAR----------- 39
Query: 312 LSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTP 371
E R R+E ++K EEE+ ++ ++ + A+ N V D+++ KT +
Sbjct: 40 ---ERRRRARQERLRQKQEEESLGQVTDQVEVNAQ---NSVPDEEA----KTTTTNTQVE 89
Query: 372 GKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREY 431
G E F E L ++ E ++R +E + + E + + +N+T E
Sbjct: 90 GDDEAAFLERLARREERRQKRLQEALERQKEFDPT-ITDASLSLPSRRMQNDT----AEN 144
Query: 432 EELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHE 491
E K ++S S Q + + E + + +K + EE + + + E +E+
Sbjct: 145 ETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIG 204
Query: 492 EDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAAL 551
E+ V+V K+ V M + Q++ ++E+ R ++ D
Sbjct: 205 ENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER------------EQGSDEIS 252
Query: 552 QKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSE 597
++ EEE++E + + E EE+ R A KK + +++E
Sbjct: 253 HHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298
Score = 43.5 bits (101), Expect = 6e-04
Identities = 56/240 (23%), Positives = 100/240 (41%), Gaps = 29/240 (12%)
Query: 386 MEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEE-----------NETFGLSREYEEL 434
M++ +RR E R+ + EM + E E++ + +++EE E +E E L
Sbjct: 1 MDDFERRRELRRQKREEM-RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
Query: 435 IKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEE---ERARRRAIDLEIKEREAENFHE 491
++ + A+N E + +++ E ER RR + + +EA +
Sbjct: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
Query: 492 EDDVDVRPARKSEAPFTHKVNMKAR---FEQMAKAREEEEQRRIEEQKLLRMQFEQ---R 545
E D + A S P N A E+ K+ +E+ IEE + + +++ R
Sbjct: 120 EFDPTITDASLS-LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAE-------DEEQTRSGAPWFKKPLKNTSVVDSEP 598
+ + ++ +E+EEEEE GS E +E+ T S LKN + EP
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/202 (22%), Positives = 83/202 (41%), Gaps = 33/202 (16%)
Query: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRE 64
SQ E + K T+ G+ V K EA + E +R E+ RR+
Sbjct: 493 SQNGEFMTHKLKHTENTFSRPGGRASVDTK-EAEGAPQVEAGKRL---EELRRRRGETES 548
Query: 65 REWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE 124
E+ + KQ+ +++ + ++E+ K+++EE+RK EEE
Sbjct: 549 EEFEKLKQK---------QQEAALELEEL-----------------KKKREERRKVLEEE 582
Query: 125 RKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSG- 183
+RR +++ K + + E + E+IE E + +D L P K + G
Sbjct: 583 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS 642
Query: 184 --KMKKNFEDLEKEREEKERIK 203
K+++ E L K ++ +K
Sbjct: 643 SLKIEERAEFLNKSVQKSSGVK 664
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 122 bits (306), Expect = 1e-27
Identities = 127/531 (23%), Positives = 247/531 (46%), Gaps = 105/531 (19%)
Query: 36 EAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYV 95
E ++ RE+ + R ++EK RR+E+ + E+E R+QE EM+ +E
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE--EMMWEKEE------------ 363
Query: 96 PKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
K+ + + + EK R++E+ +EE+ R +E+ M E+ KI+ + KR E+ E I
Sbjct: 364 -KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE-EKIRE 421
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE--KERIKYEEDKRIRYE 213
E K ++ K+++ E + ++ ++ ++ K E ++IR E
Sbjct: 422 QEKRQEQE------------AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE 469
Query: 214 EQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKR 273
E+R +E + ++ E +KE + + K+ +E + RQE + ++ EE+ R++
Sbjct: 470 EKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQ 529
Query: 274 LEEEKRAFEEARRQ--MVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEE 331
E+ R E+ R Q M E+E+ + KI+ EE +RQ +ED+ + EE
Sbjct: 530 EEKMWRQEEKIREQEEMWREEEKMHEQEKIW------------EEEKRQEQEDKMWRQEE 577
Query: 332 EARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKR 391
+ R E+E+K + + EE +++ +EEKR
Sbjct: 578 KIR---EQEEKVWRQ--------------------------------EEKIRE--QEEKR 600
Query: 392 RTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSK 451
+ +EE+ K E + +E E+ QE E+ E E RE EE+ + +
Sbjct: 601 QEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE--KIREQEEMTQEQE------------ 646
Query: 452 FEKIGQLSEK--EIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTH 509
EK+G+ EK E ++K++E+ + +I+E+E + +E+ + + E
Sbjct: 647 -EKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQE--- 702
Query: 510 KVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEE 560
+ +EQ K E+EE+ + +E+K+ R + + E + L+++ E+ +E
Sbjct: 703 ----EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 105 bits (263), Expect = 1e-22
Identities = 124/557 (22%), Positives = 249/557 (44%), Gaps = 44/557 (7%)
Query: 52 DEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEK 111
++K + Q RE + I+ + E ++ + V +L G + + +
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 169
Query: 112 QRQEEQRKRTEEERKRRIEQDMLEKRKIQR---ELAKRAE--QIEDINNTGTESASEEGD 166
+ E ++ + +K+K R EL K + +E NT T+ +E +
Sbjct: 170 SW------KFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 223
Query: 167 DSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKE--AKC 224
L + V+S K+ +++ N ++L+++ E + + ++ + + L+ AK
Sbjct: 224 AKLQEKLQLVESEKS--EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 281
Query: 225 LSLVMDDEIESEAKKESLSP-GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEE 283
+ V ++E+ + ++ + + +E E + QE +K E+E + R +EEK +E
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQE 341
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLK----LSFEEMERQRREDEKRKAEEEARRRIEE 339
+M+ E EE + + K++ + +E+ E+ RR++E +EE R +EE
Sbjct: 342 ---EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 398
Query: 340 ---EKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEE 396
E++ E ++ E K QE + E E+ K + +E+K +EE
Sbjct: 399 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 458
Query: 397 RKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIG 456
+ H E EK E+ RQE E + E E EE+ + K Q + ++ + EK+
Sbjct: 459 KIH--EQEKIREEEKRQEQEEMWRQEEKI---HEQEEIWRQKEKMHEQEEKIRKQEEKVW 513
Query: 457 QLSEK--EIQKKIEEERARRRAIDLEIKE-----REAENFHEEDDVDVRPARKSEAPFTH 509
+ EK E ++KI E+ + + +I+E RE E HE++ + R+ +
Sbjct: 514 RQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMW 573
Query: 510 KVNMKAR------FEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEG 563
+ K R + Q K RE+EE+R+ +E+K+ + + + RE + +Q++ E+ E+E
Sbjct: 574 RQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE 633
Query: 564 SIMNGSTAEDEEQTRSG 580
I E++ + G
Sbjct: 634 KIREQEEMTQEQEEKMG 650
Score = 101 bits (252), Expect = 2e-21
Identities = 115/522 (22%), Positives = 236/522 (45%), Gaps = 84/522 (16%)
Query: 62 IRERE-WNRRKQEIKEMLASDDE--EDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQR 118
+ E E WNR Q+ +E + +E ++ K+++ + EK R++E++
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQE---------------QEEKIREQEEK 329
Query: 119 KRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKS 178
R +EE+ RR E+ M EK + R + + E+ E E+ + +
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR-------RQ 382
Query: 179 YKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAK 238
+ + ++ +LE++ E+E+I+ +E+KR E+ R K + E + +
Sbjct: 383 EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-------QEQEAKMWRQ 435
Query: 239 KESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDT 298
+E + + K+ +E + RQE + + E K EEEKR +E +M ++E+ +
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQE----KIREEEKRQEQE---EMWRQEEKIHEQ 488
Query: 299 AKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSP 358
+I++ K E E + R+ E++ +E + R +EEK + +
Sbjct: 489 EEIWRQ------KEKMHEQEEKIRKQEEKVWRQEEKIREQEEK-----------IREQEE 531
Query: 359 EMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEE 418
+M++ E E + EEEK +E+ + + ++QE + RQE
Sbjct: 532 KMWRQ-----------EEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580
Query: 419 EEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAID 478
E+E + + R+ E++ + + Q + + + EKI +E ++KI+E+ + R +
Sbjct: 581 EQEEKVW---RQEEKIREQEEKRQEQEEKMWKQEEKI-----REQEEKIQEQEEKIREQE 632
Query: 479 LEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLL 538
+I+E+E +E+ + + + E + + + Q K RE+E++ R +E+K+
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKI- 691
Query: 539 RMQFEQREIDAALQKKREE--EEEEEGSIMNGSTAEDEEQTR 578
RE + +Q++ E+ E+EE+ E EE+ R
Sbjct: 692 ------REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 727
Score = 99.0 bits (245), Expect = 1e-20
Identities = 113/532 (21%), Positives = 244/532 (45%), Gaps = 46/532 (8%)
Query: 54 KQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQR 113
++++ ++YI E R ++ + +E++ K K ++ + +E ++
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK---------LQEKLQLVESEK 237
Query: 114 QEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITV 173
E Q E +RK + +L ++++Q E ++++ ++ E + L
Sbjct: 238 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQ 297
Query: 174 VPVKSYKTSGKMK----KNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVM 229
K ++ K++ K E EK RE++E+I+ +E+K R EE +E M
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK------M 351
Query: 230 DDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMV 289
+ E +KE + ++ +E+ E+ R++ +EE + LEE+ E+ R Q
Sbjct: 352 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ-- 409
Query: 290 NEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARR 349
+E+ Q+ KI + + + + E + RE E++ E+E + +EEK E R
Sbjct: 410 --EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 467
Query: 350 NMVVDDDSPEMY----KTISQEFLTPGKLEINFEELLKQKMEE-------------EKRR 392
+ EM+ K QE + K +++ +E +K EE EK R
Sbjct: 468 EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIR 527
Query: 393 TEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKF 452
+EE+ + E + +E E++ +E + E+ + + + E+ K+ R Q + ++ +
Sbjct: 528 EQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWR----QEEKIREQE 583
Query: 453 EKIGQLSEK--EIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHK 510
EK+ + EK E ++K +E+ + + +I+E+E + +E+ + + + E +
Sbjct: 584 EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ 643
Query: 511 VNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEE 562
+ EQ K E+EE+ + +E+ + R + + RE + ++++ E+ E+E
Sbjct: 644 EQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQE 695
Score = 92.4 bits (228), Expect = 1e-18
Identities = 95/409 (23%), Positives = 196/409 (47%), Gaps = 27/409 (6%)
Query: 35 FEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAY 94
+E ++ R + ++EK RR+E+ + E+E R+QE EM+ + EE + EK +
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE--EMMW-EKEEKIRELEEKMH 401
Query: 95 VPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKI---QRELAKRAEQIE 151
+ + + E EK R++E+R+ E + R+ E+ ++ KI ++++ ++ E+I
Sbjct: 402 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 461
Query: 152 DINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIR 211
+ E +E ++ + + + +K E EK R+++E++ +E+K IR
Sbjct: 462 EQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEK-IR 520
Query: 212 YEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEAR 271
+E++ +E K + E +E + + +EE +RQ QE++ + EE+ R
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580
Query: 272 KRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEE 331
++ E+ R E+ R Q E+ + K + R + K+ +E + + +E++ R+ EE
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEE 640
Query: 332 ---EARRRIEEEKKAFAEARRNMVVDDDSP--------EMYKTI--------SQEFLTPG 372
E ++ E+++ E M +++ E K I QE +
Sbjct: 641 MTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQE 700
Query: 373 KLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFE-QLRQEMGEEEE 420
+ E +E+ K +EEK + +EE+ + E + E E +LRQ+ + +E
Sbjct: 701 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 85.9 bits (211), Expect = 1e-16
Identities = 70/340 (20%), Positives = 165/340 (48%), Gaps = 31/340 (9%)
Query: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRERE---WNR-----RKQEIKEMLA 79
K ++K ++ +E+ + ++EK R +E+ IRE+E W + +++I+E
Sbjct: 412 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 471
Query: 80 SDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRK--------RTEEERKRRIEQ 131
++E++ + EK + + K + E E++ ++++ K R +EE+ R E+
Sbjct: 472 RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEE 531
Query: 132 DML---EKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTS-GKMKK 187
M EK + Q E+ + E++ + E +E +D + ++ + + ++
Sbjct: 532 KMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEE 591
Query: 188 NFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCL---SLVMDDEIESEAKKESLSP 244
+ E++R+E+E ++++++IR +E++ +E K + + E ++ ++E +
Sbjct: 592 KIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGE 651
Query: 245 GKLKLTFEELERQRQENRKKQAEEEAR---KRLEEEKRAFEEARRQMVNEDEENQDTAKI 301
+ K+ +E + Q QE + EE+ R K++ E++ E M ++E+ + +
Sbjct: 652 QEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE- 710
Query: 302 FKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEK 341
+ + + +E E + R E++ E+E R R +EEK
Sbjct: 711 ----KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Score = 64.7 bits (156), Expect = 3e-10
Identities = 101/450 (22%), Positives = 190/450 (42%), Gaps = 45/450 (10%)
Query: 133 MLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLL--ITVVPVKSYKTSGKMKKNFE 190
M+ K Q +LA+ EQ+ D + S D+ I TSG +
Sbjct: 50 MMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPED 109
Query: 191 DLEKEREEKERIKYEEDKRIRYEE----QRPSLKEAKCLSLVMDDEIESEAKKESLSPGK 246
+ + + +E ++ E + ++ Q+ L+ A S ++E EA+ + +S
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR-DLISRLH 168
Query: 247 LKLTFE-ELERQRQE--NRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFK 303
F ELE+ +KK+A+ + +E E R + ++E + AK+ +
Sbjct: 169 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 228
Query: 304 GYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKT 363
KL E E+ E + +E +R++E K + + D E+
Sbjct: 229 -------KLQLVESEKS----EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 277
Query: 364 ISQEFLTPGKLEINFEE-----LLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEE 418
+ KL+ EE L Q+ EE+ R EE+ + E +++ E++R++ +
Sbjct: 278 SA-------KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 330
Query: 419 EEENETFGLSRE--YEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRA 476
E+ E E +E+ K++R Q + + K EK+ + E +K+ + R
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRR----QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 386
Query: 477 IDLEIKEREAEN-FHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQ 535
+ E K RE E HE++ + + ++ E + + R EQ AK +EE+ R +E+
Sbjct: 387 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE--QEKRQEQEAKMWRQEEKIREQEE 444
Query: 536 KLLRMQ---FEQREIDAALQKKREEEEEEE 562
K+ + + Q E +K REEE+ +E
Sbjct: 445 KIREQEKKMWRQEEKIHEQEKIREEEKRQE 474
Score = 54.7 bits (130), Expect = 3e-07
Identities = 54/275 (19%), Positives = 127/275 (46%), Gaps = 33/275 (12%)
Query: 325 EKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLT----PGKLEINFEE 380
+K+KA+ +E E RN + D++ E + ++ ++++N +E
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 246
Query: 381 LLKQKMEEEKRRTEEER-KHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKR 439
L K+K+E K +++ + + + +E + + ++ + EENE + + +E
Sbjct: 247 L-KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE------ 299
Query: 440 SGSIQAKNLKSKFEKIGQLSEK--EIQKKIEEERARRRAIDLEIKEREAENFHEED---D 494
EK+ + EK E ++KI+E+ + R + +I+E+E + +E+ +
Sbjct: 300 -------------EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE 346
Query: 495 VDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKK 554
+ + R+ E + + M+ + E M E+EE+ R +E+ + + + RE++ + ++
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRQEEMMW---EKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 403
Query: 555 REEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLK 589
+ E+EE E E++ A +++ K
Sbjct: 404 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 438
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 119 bits (297), Expect = 1e-26
Identities = 118/545 (21%), Positives = 259/545 (47%), Gaps = 54/545 (9%)
Query: 32 KDKFEAMQRAREERNQRRSRDEKQRRKEQYIRERE--WNRRKQEIKEMLASDDEEDVSSK 89
K E Q+ R++ + +DE+ R KE+ +RE+E W + ++ +E + E+ +
Sbjct: 383 KQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ 442
Query: 90 VEKAYVPKLTGTVKGRFAEMEKQ-RQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAE 148
EK + R E EK+ R+EE+ R +EE+ ++ E++M E+ + + + + E
Sbjct: 443 EEKMQEEE-------RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 495
Query: 149 QIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDK 208
Q E + + +E ++ + ++ + +K EK RE+++++ +E+++
Sbjct: 496 QKEKL---WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM-WEQEE 551
Query: 209 RIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEE 268
++R +EQ+ + D E E K + K T+++ E+ R+E R ++ E
Sbjct: 552 KMRDQEQK-----------MWDQEERMEKKTQEQE----KKTWDQEEKMREEERMRERE- 595
Query: 269 EARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRK 328
K++ EE+ E +M ++E+ Q+ + + + + +E E + E E++
Sbjct: 596 ---KKMREEEEMMREQEEKMQEQEEKMQEQEE-----KMWEQEEKMQEQEEKMWEQEEKM 647
Query: 329 AEEEAR----RRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQ 384
E+E + +R+ E+K+ E + + + K QE + E + ++
Sbjct: 648 WEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQE 707
Query: 385 KMEEEKRRTEEERKHKLE---MEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSG 441
KM EE+ E E+K + E M +QE + QE +E+E E + E EE + +
Sbjct: 708 KMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMW----EQEEKMWEQEEK 763
Query: 442 SIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPAR 501
+ + L + EK+ + + + Q+KI E+ + R + +++ +E + +E+ + + +
Sbjct: 764 MWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK 823
Query: 502 ---KSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEE 558
+ E + + M + E+M E+ E++ +++ +R Q + ++ +K RE+E
Sbjct: 824 MWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQ--EEKMRGQEEKMREQE 881
Query: 559 EEEEG 563
E+ G
Sbjct: 882 EKMRG 886
Score = 114 bits (286), Expect = 2e-25
Identities = 118/542 (21%), Positives = 256/542 (47%), Gaps = 43/542 (7%)
Query: 30 DVKDKFEAMQRARE--ERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVS 87
+VK+ ++RA+ + Q + E+ R+E+ +RE+E RKQE K + +
Sbjct: 247 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQE 306
Query: 88 SKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRA 147
K+ + + EK ++E+R R +E+ R E+++ E Q+EL ++
Sbjct: 307 GKMRE---------------QEEKMWRQEKRLREQEKELREQEKELRE----QKELREQE 347
Query: 148 EQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEED 207
EQ+++ E + + + + ++ +M+ E +K R+++ER+ +E+D
Sbjct: 348 EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR---EQEQKMRDQEERM-WEQD 403
Query: 208 KRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAE 267
+R+R +E+R +E M +++E +++ + + K T ++ E+ ++E R ++ E
Sbjct: 404 ERLREKEERMREQEK------MWEQVEKMREEKKMQEQEKK-TRDQEEKMQEEERIRERE 456
Query: 268 EEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKR 327
++ R EEE+ E+ + E+ + K ++ R + K E E+ + ++EK
Sbjct: 457 KKMR---EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
Query: 328 KAEEEARRRIEE----EKKAFAEARRNMVVDDDSPEMYKTISQE---FLTPGKLEINFEE 380
+EE R EE EKK + + + D + K QE + ++E +E
Sbjct: 514 WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQE 573
Query: 381 LLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRS 440
K+ ++E++ EEER + E + +E E++ +E E+ +E E + + E++ + +
Sbjct: 574 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE-KMQEQEEKMWEQEEK 632
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPA 500
Q + + + EK+ + EK +++ E+ + +++E+E EE +
Sbjct: 633 MQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKM 692
Query: 501 RKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEE 560
K K + + + RE E++ R EE+ + + + +E + +Q++ EE E
Sbjct: 693 EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWE 752
Query: 561 EE 562
+E
Sbjct: 753 QE 754
Score = 88.2 bits (217), Expect = 2e-17
Identities = 96/378 (25%), Positives = 174/378 (46%), Gaps = 30/378 (7%)
Query: 51 RDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEME 110
R EK R +E + E+E R QE K D EE + K ++ K T + + E E
Sbjct: 535 RQEKMREQEDQMWEQEEKMRDQEQKMW---DQEERMEKKTQEQ--EKKTWDQEEKMREEE 589
Query: 111 KQRQEEQRKRTEEERKRRIEQDMLEKR-KIQRELAKRAEQIEDINNTGTESASEEGDDSL 169
+ R+ E++ R EEE R E+ M E+ K+Q + K EQ E + E E ++ +
Sbjct: 590 RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ--EEKMWEQEEKM 647
Query: 170 LITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVM 229
+ + + K+ + EK +E+E+++ +E+K E+ +E + +
Sbjct: 648 WEQEEKMWEQQRLPEQKEKLWEHEK-MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQ 706
Query: 230 DDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEA----R 285
+ E E+ +E + K EE E R++ K Q +EE + EEE EE
Sbjct: 707 EKMREEESMRE-----REKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQE 761
Query: 286 RQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFA 345
+M + + K+++ + + + +E+ E+ R ++EK + +EE R EE+ +
Sbjct: 762 EKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQE 821
Query: 346 EARRNMVVDDDSPEMYKTISQEFLTPGKLEINF--EELLKQKME-EEKRRTEEERKHKLE 402
E + K QE G+ E + EE +++KM+ +E++ E+E K + +
Sbjct: 822 EKMWG--------QEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQ 873
Query: 403 MEKQEFEQLRQEMGEEEE 420
EK EQ + G+EE+
Sbjct: 874 EEKMR-EQEEKMRGQEEK 890
Score = 87.0 bits (214), Expect = 5e-17
Identities = 94/489 (19%), Positives = 226/489 (46%), Gaps = 51/489 (10%)
Query: 86 VSSKVEKA--YVPKLTGTVKGRFAEMEKQR-QEEQRKRTEEERKRRIEQDMLEKRKIQ-- 140
VS++ +KA Y+ +LT E+ + E+ K+ E + ++ EK +IQ
Sbjct: 188 VSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLN 247
Query: 141 -RELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEK 199
+EL ++ E+ + + + +T+ ++ + E+ RE++
Sbjct: 248 VKELKRKLERAKFL----------------------LPQVQTNTLQEEMWRQEEELREQE 285
Query: 200 ERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQ 259
++I+ +E+K R EE+ L+E + ++++ + K+ +L+ +EL Q++
Sbjct: 286 KKIRKQEEKMWRQEER---LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKE 342
Query: 260 ENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMER 319
+++ +E +++ E++ E +M ++E + K E E+
Sbjct: 343 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK------------QMREQEQ 390
Query: 320 QRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFE 379
+ R+ E+R E++ R R +EE+ E V + E K QE T + E E
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQV--EKMREEKKMQEQEKKTRDQEEKMQE 448
Query: 380 ELLKQKMEEEKRRTEE---ERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIK 436
E ++ E++ R EE E++ K++ +++ + ++ +++ E E E++ +
Sbjct: 449 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 508
Query: 437 LKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVD 496
+ Q + ++ + E GQ + Q+K+ E+ + + +++++E + + +E+ ++
Sbjct: 509 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERME 568
Query: 497 VRPARKSEAPFTHKVNMKAR---FEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQK 553
+ + + + + M+ E+ K REEEE R +E+K+ + + +E + + +
Sbjct: 569 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWE 628
Query: 554 KREEEEEEE 562
+ E+ +E+E
Sbjct: 629 QEEKMQEQE 637
Score = 85.9 bits (211), Expect = 1e-16
Identities = 99/417 (23%), Positives = 204/417 (48%), Gaps = 42/417 (10%)
Query: 190 EDLEKEREE-KERIKYEEDKR----IRYEEQRPSLKEAK-CLSLVMDDEIESEA--KKES 241
E+L+K+ E +E++ E ++ + +E + L+ AK L V + ++ E ++E
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 280
Query: 242 LSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEAR-RQMVNEDEENQDTAK 300
L + K+ +E + RQE R + E+E + R +EEK +E R R+ E E + +
Sbjct: 281 LREQEKKIRKQEEKMWRQEERLR--EQEGKMREQEEKMWRQEKRLREQEKELREQEKELR 338
Query: 301 IFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARR---RIEEEKKAFAEARRNMVVDDDS 357
K R + ++ +E + +E++ R+ EE+ R R+ E++K E + M D
Sbjct: 339 EQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKM--RDQE 396
Query: 358 PEMYKTISQEFLTPGKLEINFEELL---KQKMEEEKRRTEEERKHKLEMEK-QEFEQLRQ 413
M++ E L + + +E + +KM EEK+ E+E+K + + EK QE E++R+
Sbjct: 397 ERMWE--QDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRE 454
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEI-QKKIEEERA 472
+ EE ET RE EE ++ + + + + + +++ + EK Q+K++E+
Sbjct: 455 REKKMREEEETM---REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 511
Query: 473 RRRAIDLEIKEREA-----------ENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMA 521
+ + +I+++E E E++D + + E + M + E+M
Sbjct: 512 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED---QMWEQEEKMRDQEQKMWDQEERME 568
Query: 522 KAREEEEQRRIEEQKLLRMQFEQREIDAALQKKRE--EEEEEEGSIMNGSTAEDEEQ 576
K +E+E++ ++++ +R + RE + ++++ E E+EE+ E EE+
Sbjct: 569 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625
Score = 73.2 bits (178), Expect = 8e-13
Identities = 111/557 (19%), Positives = 235/557 (42%), Gaps = 40/557 (7%)
Query: 46 NQRRSRDEKQRRKEQYIREREWN-----RRKQEIKEMLASDDEEDVSSKVEKAYVPKLTG 100
+++ +++ K+++ R+WN + K+ + ++ + P+ T
Sbjct: 14 SEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSGGCHSPEDTQ 73
Query: 101 TVKGRFAEMEKQRQEEQR--KRTEEERKRRIEQDMLEKRKIQREL---AKRAEQIEDINN 155
+ + E +K + Q +R E + I +K +++ L A + ED N
Sbjct: 74 QNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFED-GN 132
Query: 156 TGTESA-----SEEGDDSLL----ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEE 206
GT S+ S+ S L +++P +S +G++ ++ + + +
Sbjct: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
K RY E+ ++A L L + E KK++ + KL E E+ + K
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQE-KLPLAESEKSEIQLNVK-- 249
Query: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEK 326
E +++LE K + + + E+ Q+ + R + K+ +E + R+E+
Sbjct: 250 --ELKRKLERAKFLLPQVQTNTLQEEMWRQE-----EELREQEKKIRKQEEKMWRQEERL 302
Query: 327 RKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKM 386
R+ E + R E+E+K + + +R + + E K + ++ + E E+ K
Sbjct: 303 REQEGKMR---EQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWE 359
Query: 387 EEEKRRTEEERKHKLE-----MEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSG 441
+EEK R +EE+ + E EKQ EQ ++ +EE E RE EE ++ +
Sbjct: 360 QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKM 419
Query: 442 SIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPAR 501
Q + ++ EK Q EK+ + + E+ + R + E K RE E E + ++
Sbjct: 420 WEQVEKMRE--EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 477
Query: 502 KSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEE 561
++ K + R + + E+E+ + +E+K+ + + R+ + ++++ +E
Sbjct: 478 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 537
Query: 562 EGSIMNGSTAEDEEQTR 578
+ E EE+ R
Sbjct: 538 KMREQEDQMWEQEEKMR 554
Score = 47.4 bits (111), Expect = 4e-05
Identities = 46/202 (22%), Positives = 94/202 (46%), Gaps = 18/202 (8%)
Query: 32 KDKFEAMQRAREERN---QRRSRDEKQRRKEQYIREREWNRRKQEIK----EMLASDDEE 84
++K E + +E++ ++ +E R +E+ +RE E R+QE K E + EE
Sbjct: 689 QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Query: 85 DVSSKVEKAYVPKLTGTVKGRFAEM-----EKQRQEEQRKRTEEERKRRIEQDML--EKR 137
++ + EK + + + R E E ++ +EQ K E+E K R +++ + ++
Sbjct: 749 EMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEE 808
Query: 138 KIQRELAKRAEQIEDINNTGTESASEE----GDDSLLITVVPVKSYKTSGKMKKNFEDLE 193
K++ + K Q E + + +E G + + K G+ +K E E
Sbjct: 809 KMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE 868
Query: 194 KEREEKERIKYEEDKRIRYEEQ 215
K R ++E+++ +E+K EE+
Sbjct: 869 KMRGQEEKMREQEEKMRGQEEK 890
Score = 36.2 bits (82), Expect = 0.10
Identities = 30/128 (23%), Positives = 63/128 (49%), Gaps = 14/128 (10%)
Query: 33 DKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
+K + ++ E+ + R ++EK R +E+ +R +E R QE K EE + + EK
Sbjct: 781 EKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMW---GQEEKMWGQEEK 837
Query: 93 AYVPKLTGTVKGRFAEM--EKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQI 150
+ G+ +M ++++ EE+ + EE+ + + E+ ++ K++ + K Q
Sbjct: 838 MW---------GQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQE 888
Query: 151 EDINNTGT 158
E I G+
Sbjct: 889 EKIYCVGS 896
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 118 bits (296), Expect = 2e-26
Identities = 142/556 (25%), Positives = 260/556 (46%), Gaps = 87/556 (15%)
Query: 30 DVKDKFEAMQRARE--ERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVS 87
+VK+ ++RA+ + Q + E+ R+E+ +RE+E RKQE K +
Sbjct: 209 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE------ 262
Query: 88 SKVEKAYVPKLTGTVKGRFAEME-KQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKR 146
R E E K R++E++ R +E+R R E+++ E+ K RE K
Sbjct: 263 -----------------RLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKL 305
Query: 147 AEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEE 206
EQ E + EE K ++ KM+ E EK ++ER+ +E+
Sbjct: 306 REQEEQMQE------QEE------------KMWEQEEKMR---EQEEKMWRQEERL-WEQ 343
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
+K++R +EQ+ +E + M ++ E +KE + K+ +E+ E+ ++E R ++
Sbjct: 344 EKQMREQEQKMRDQEER-----MWEQDERLREKEERMREQEKM-WEQEEKMQEEERIRER 397
Query: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEK 326
E++ R EEE+ E+ + E+ + K ++ R + K E E+ + ++EK
Sbjct: 398 EKKMR---EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 454
Query: 327 RKAEEEARRRIEE----EKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFE--E 380
+EE R EE EKK + + + D + K QE + E +E E
Sbjct: 455 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDE 514
Query: 381 LLKQK---MEEEKRRTEEERKHKLEMEKQEFEQL----RQEMGEEEEENETFGLSREYEE 433
L++K M E+K+ ++E K + E + QE E+ ++M EEE E RE EE
Sbjct: 515 RLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 574
Query: 434 LIKLKRSGSIQAKNLKSKFEKIGQLSEK--EIQKKIEEERARRRAIDLEIKEREAENFHE 491
+++ Q + ++ + EK+ + EK E ++K++E+ + + ++ E+E E
Sbjct: 575 MMRE------QEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE-----E 623
Query: 492 EDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAAL 551
ED + + E + + +EQ K RE+EE+ R +E+K+ + + RE + +
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKM 683
Query: 552 Q----KKREEEEEEEG 563
Q K RE+EE+ G
Sbjct: 684 QGQEEKMREQEEKMRG 699
Score = 95.5 bits (236), Expect = 1e-19
Identities = 94/402 (23%), Positives = 189/402 (47%), Gaps = 34/402 (8%)
Query: 31 VKDKFEAMQRARE--ERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSS 88
+++K E M+ + E+ ++ +E+ R +E+ +RE E R+QE K EE++
Sbjct: 368 LREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK---MQKQEENMWE 424
Query: 89 KVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAE 148
+ EK + + K + E EK QE++ K E+E K R +++M + K K E
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKM-QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 483
Query: 149 QIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDK 208
Q + + + +E K + ++ +E E+ RE++ER++ E+ K
Sbjct: 484 QEDQMWEQEEKMRDQE--------------QKMWDQEERMWEQDERLREKEERMR-EQKK 528
Query: 209 RIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEE 268
+ EE+ K+ + D+ E ++E + + K+ EE E R++ K Q +E
Sbjct: 529 MWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE-EMMREQEEKMQEQE 587
Query: 269 EARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLK----LSFEEMERQRRED 324
E K E+E++ +E+ + E++ + K+++ K++ + +E+ E+ + ++
Sbjct: 588 E--KMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQE 645
Query: 325 EK------RKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINF 378
EK + E+E + R +EEK E + + + K QE G+ E +
Sbjct: 646 EKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMW 705
Query: 379 EELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEE 420
+ K +EEK +EE + K E + + E++++ + E EE
Sbjct: 706 GQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEE 747
Score = 93.6 bits (231), Expect = 5e-19
Identities = 120/491 (24%), Positives = 233/491 (47%), Gaps = 54/491 (10%)
Query: 108 EMEKQRQEEQRK-RTEEERKRRIEQDMLE-KRKIQRELAKRAEQIEDINNTGTESASEEG 165
E++K+ E Q K R E K I+ ++ E KRK++R AK N E +E
Sbjct: 184 ELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLER--AKFLLPQVQTNTLQEEMWRQEE 241
Query: 166 DDSLLITVVPVKSYKTSGKMKKNFEDLEKE----REEKERIKYEEDKRIRYEEQ--RPSL 219
+ + K K KM + E L ++ RE++E+++ +E KR+R +E+ R
Sbjct: 242 E----LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQE-KRLREQEKELREQE 296
Query: 220 KEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR----KKQAEEEARKRLE 275
KE + + + E + + ++E + + K+ +E + RQE R +KQ E+ +K +
Sbjct: 297 KELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD 356
Query: 276 EEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARR 335
+E+R +E+ R + ++E ++ K+++ +E ER R ++K + EEE R
Sbjct: 357 QEERMWEQDER-LREKEERMREQEKMWEQEE------KMQEEERIREREKKMREEEETMR 409
Query: 336 RIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEE 395
EE+ + E NM ++ K Q+ L P + E +E+ Q+ EE+ EE
Sbjct: 410 EQEEKMQKQEE---NMWEQEE-----KEWQQQRL-PEQKEKLWEQEKMQEQEEKIWEQEE 460
Query: 396 ERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKI 455
+ + + EM QE + RQE E+E+ + +E+ K++ Q + + + E++
Sbjct: 461 KIRDQEEMWGQEKKMWRQEKMREQED-------QMWEQEEKMRD----QEQKMWDQEERM 509
Query: 456 GQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKA 515
+ E+ +++K E R +++ E K RE + E++ + E + M+
Sbjct: 510 WEQDER-LREKEERMREQKKMWQQEEKMREEKKTQEQE----KKTWDQEEKMREEERMRE 564
Query: 516 RFEQMAKARE---EEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAE 572
R ++M + E E+E++ E+++ +R Q E+ +++EE+ E+ M E
Sbjct: 565 REKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624
Query: 573 DEEQTRSGAPW 583
D+ Q + W
Sbjct: 625 DKMQEQEEMMW 635
Score = 84.7 bits (208), Expect = 2e-16
Identities = 91/395 (23%), Positives = 183/395 (46%), Gaps = 40/395 (10%)
Query: 190 EDLEKEREE-KERIKYEEDKR----IRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSP 244
E+L+K+ E +E+++ E ++ + +E + L+ AK L ++++ +E +
Sbjct: 183 EELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLL----PQVQTNTLQEEMWR 238
Query: 245 GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKG 304
+ +L +E + ++QE + + EE R++ + + E+ RRQ E+ ++ + K
Sbjct: 239 QEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE 298
Query: 305 YRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTI 364
R K E E Q +E E++ E+E + R +EEK E R E K +
Sbjct: 299 LREQK---KLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEER--------LWEQEKQM 347
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENET 424
++ E E ++ E+E+R E+E+ + E + QE E++R+ + EE ET
Sbjct: 348 REQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEET 407
Query: 425 FGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKER 484
RE EE ++ + E + + EKE Q++ E+ + +++E+
Sbjct: 408 M---REQEE-------------KMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 451
Query: 485 EAENFHEEDDV-DVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFE 543
E + + +E+ + D E + M+ + +QM E+EE+ R +EQK+ +
Sbjct: 452 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM---WEQEEKMRDQEQKMWDQEER 508
Query: 544 QREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTR 578
E D L++K E E++ +E++T+
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ 543
Score = 63.5 bits (153), Expect = 6e-10
Identities = 94/397 (23%), Positives = 179/397 (45%), Gaps = 61/397 (15%)
Query: 235 SEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEE 294
++ KK+ ++ G T E+ KK A + ++ L E A + R + + E
Sbjct: 45 TDTKKKKINNGTNPETTTSEGCHSPEDEKK-ASHQHQEALRREIEAQDHTIRILTCQKTE 103
Query: 295 -------NQDTAKIFKGYRPGKLKLSFEEM--------ERQRREDEKRKAEEEARRRIEE 339
+QD A+ F+ G+ K + E QR ++A R IEE
Sbjct: 104 LETALYYSQDAARKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEE 163
Query: 340 ---EKKAFA-EARRNMVVDDD----SPEMYKTISQEFLTPGKLEINFEELLKQKMEEEK- 390
E+ A + E RN + +++ + E+ + + ++++N +EL K+K+E K
Sbjct: 164 LTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKEL-KRKLERAKF 222
Query: 391 ---------------RRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELI 435
R+ EE R+ + ++ KQE + RQE E+E G RE EE
Sbjct: 223 LLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQE----GKMREQEE-- 276
Query: 436 KLKRSGSIQAKNLKSKFEKIGQLSEKEI--QKKIEEERARRRAIDLEIKEREAENFHEED 493
K++R Q K L+ + +++ + EKE+ QKK+ E+ + + + ++ E+E E E++
Sbjct: 277 KMRR----QEKRLREQEKELRE-QEKELREQKKLREQEEQMQEQEEKMWEQE-EKMREQE 330
Query: 494 DVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQK 553
+ + R+ E + + M+ EQ K R++EE+ ++++L + RE + ++
Sbjct: 331 E---KMWRQEERLWEQEKQMR---EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 384
Query: 554 KREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKN 590
+ + +EEE E+EE R +K +N
Sbjct: 385 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 421
Score = 59.7 bits (143), Expect = 9e-09
Identities = 80/365 (21%), Positives = 156/365 (42%), Gaps = 80/365 (21%)
Query: 231 DEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARK-----RLEEEKRAFEEAR 285
+E+ E SL + +T EEL+++ E ++K E+ K ++E KR E A+
Sbjct: 162 EELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAK 221
Query: 286 ------------RQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEA 333
+M ++EE ++ K K++ E+M RQ E+R E+E
Sbjct: 222 FLLPQVQTNTLQEEMWRQEEELREQEK--------KIRKQEEKMWRQ----EERLREQEG 269
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRT 393
+ R +EEK E R + E E K+ E++K R
Sbjct: 270 KMREQEEKMRRQEKRLR----------------------EQEKELREQEKELREQKKLRE 307
Query: 394 EEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFE 453
+EE+ E E++ +EQ ++M E+EE+ + R+ E L + ++ Q + ++ + E
Sbjct: 308 QEEQMQ--EQEEKMWEQ-EEKMREQEEK-----MWRQEERLWEQEKQMREQEQKMRDQEE 359
Query: 454 KIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNM 513
++ + E+ +++K E R + + + E K +E E E +
Sbjct: 360 RMWEQDER-LREKEERMREQEKMWEQEEKMQEEERIRERE-------------------- 398
Query: 514 KARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAED 573
K E+ RE+EE+ + +E+ + + ++ + ++K + E+E+ E
Sbjct: 399 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 458
Query: 574 EEQTR 578
EE+ R
Sbjct: 459 EEKIR 463
Score = 58.9 bits (141), Expect = 1e-08
Identities = 68/288 (23%), Positives = 133/288 (46%), Gaps = 37/288 (12%)
Query: 309 KLKLSFEEMERQRREDEKRKAE-----EEARRRIEEEKKAFAEARRNMVVDDDSPEMYKT 363
+LK E++ + R E K+E +E +R++E K + + N +
Sbjct: 184 ELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTL----------- 232
Query: 364 ISQEFLTPGKLEINFEELLKQKMEEEKRRTEEE-RKHKLEMEKQEFEQLRQEMGEEEEEN 422
QE + + E+ +E +K EE+ R EE R+ + +M +QE + RQE E+E
Sbjct: 233 --QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEK 290
Query: 423 ETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEK--EIQKKIEEERARRRAIDLE 480
E +E E KL+ Q + ++ + EK+ + EK E ++K+ + R + +
Sbjct: 291 ELREQEKELREQKKLRE----QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 481 IKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRM 540
++E+E + +E+ + + R E + R + K E+EE+ + EE+++
Sbjct: 347 MREQEQKMRDQEERMWEQDERLREK--------EERMREQEKMWEQEEKMQ-EEERIRER 397
Query: 541 QFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPL 588
+ + RE + + RE+EE+ + N E++E + P K+ L
Sbjct: 398 EKKMREEEETM---REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 442
Score = 44.3 bits (103), Expect = 4e-04
Identities = 32/135 (23%), Positives = 68/135 (50%), Gaps = 7/135 (5%)
Query: 25 KLGKGDVKDKFEAMQRAREERNQR-RSRDEKQRRKEQYIREREWNRRKQEIK----EMLA 79
K+ + + +DK + + E+ ++ + ++EK +E+ +RE+E R+QE K E
Sbjct: 617 KMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKM 676
Query: 80 SDDEEDVSSKVEKA--YVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR 137
+ EE + + EK K+ G + + + EK +E++ +EE + + E+ +K
Sbjct: 677 REQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKE 736
Query: 138 KIQRELAKRAEQIED 152
K+Q L + E+ +
Sbjct: 737 KMQERLPEHEERCSE 751
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 103 bits (258), Expect = 4e-22
Identities = 114/461 (24%), Positives = 223/461 (48%), Gaps = 32/461 (6%)
Query: 110 EKQRQEEQRKRTEEERKRRIEQDMLE-KRKIQR-ELAKRAEQIE-DINNTGTESASEEGD 166
EK + +++ + E K I+ ++ E KRK++R +L +Q++ + ++ G E S
Sbjct: 282 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 341
Query: 167 DSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLS 226
+ + + + +K + EK +E +E+I+ +E+K IR +E++ +E K
Sbjct: 342 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEK-IREQEEKIREQEEK--- 397
Query: 227 LVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARR 286
M + E +KE + ++ +E+ E+ R++ +EE + LEE+ E+ R
Sbjct: 398 --MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 455
Query: 287 QMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAE 346
Q +E+ Q+ KI + + + + E + RE E++ E+E + +EEK E
Sbjct: 456 Q----EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQE 511
Query: 347 ARRNMVVDDDSPEMY----KTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLE 402
R + EM+ K QE + K +I+ +E +K EE+ R +EE+ H E
Sbjct: 512 KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWR-QEEKMHDQE 570
Query: 403 --MEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSE 460
+ +QE + RQE E+E + RE EE I+ Q + + + EK+G+ E
Sbjct: 571 EKIREQEEKVWRQEEKIREQEEKI----REQEEKIR------EQEEMTQEQEEKMGEQEE 620
Query: 461 K--EIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFE 518
K E ++K++E+ + R + +I+E+E + +E+ + + E + E
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 680
Query: 519 QMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE 559
Q K +E+EE+ R +E+K+ + R+ + +Q+ +E E
Sbjct: 681 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 95.5 bits (236), Expect = 1e-19
Identities = 89/384 (23%), Positives = 181/384 (47%), Gaps = 32/384 (8%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKL 98
++ +E + + ++EK R +E+ IRE+E R+QE EM+ +E K+
Sbjct: 368 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQE--EMMWEKEE-------------KM 412
Query: 99 TGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGT 158
+ + + EK R++E+ +EE+ R +E+ M E+ KI+ + KR E+ E I
Sbjct: 413 RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE-EKIREQEK 471
Query: 159 ESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE--KERIKYEEDKRIRYEEQR 216
E K ++ K+++ E + ++ E+ ++ K E ++IR EE+R
Sbjct: 472 RQEQE------------AKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKR 519
Query: 217 PSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEE 276
+E + ++ E +KE + + K+ +E + RQE + EE+ R++ E+
Sbjct: 520 QEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEK 579
Query: 277 EKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRR 336
R E+ R Q E+ + + + + + K+ +E + +E++ ++ EE+ RR+
Sbjct: 580 VWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQ 639
Query: 337 IEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEE 396
E+ ++ + R + EM + ++ + EE K + +EEK R +EE
Sbjct: 640 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE--KMQEQEEKMRRQEE 697
Query: 397 RKHKLEMEKQEFEQLRQEMGEEEE 420
+ + E+ ++ E+ QE E E
Sbjct: 698 KMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 93.6 bits (231), Expect = 5e-19
Identities = 121/549 (22%), Positives = 241/549 (43%), Gaps = 48/549 (8%)
Query: 52 DEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEK 111
++K + Q RE + I+ + E ++ + V +L G + + +
Sbjct: 171 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 230
Query: 112 QRQEEQRKRTEEERKRRIEQDMLEKRKIQR---ELAKRAE--QIEDINNTGTESASEEGD 166
+ E ++ + +K+K R EL K + +E NT T+ +E +
Sbjct: 231 SW------KFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 284
Query: 167 DSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKE--AKC 224
L + V+S K+ +++ N ++L+++ E + + ++ + + L+ AK
Sbjct: 285 AKLQEKLQLVESEKS--EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 342
Query: 225 LSLVMDDEIESEAKKESLSP-GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEE 283
+ V ++E+ + ++ + + +E E + QE +K E+E + R +EEK +E
Sbjct: 343 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQE 402
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEE---E 340
+M+ E EE + ++ +E+ E+ RR++E +EE R +EE E
Sbjct: 403 ---EMMWEKEEKMRRQE----------EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 449
Query: 341 KKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHK 400
++ E ++ E K QE + E E+ K + +EEK +EE+ H
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIH- 508
Query: 401 LEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSE 460
E EK E+ RQE E + E RE EE+ + K Q + ++ + EK+ + E
Sbjct: 509 -EQEKIREEEKRQEQEEMWRQEEKI---REQEEIWRQKEKIHEQEEKIRKQEEKMWRQEE 564
Query: 461 K---------EIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKV 511
K E ++K+ + + R + +I+E+E + +E+ + + E
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE 624
Query: 512 NMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREE--EEEEEGSIMNGS 569
+ EQ K R +EE+ R +E+K+ + + RE + +Q++ E+ E+EE+
Sbjct: 625 QEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 684
Query: 570 TAEDEEQTR 578
E EE+ R
Sbjct: 685 MQEQEEKMR 693
Score = 85.9 bits (211), Expect = 1e-16
Identities = 83/326 (25%), Positives = 154/326 (47%), Gaps = 38/326 (11%)
Query: 35 FEAMQRAREERNQRRSRDEKQRR-------KEQYIREREWNRRKQE-IKEMLASDDEEDV 86
+E ++ R + ++EK RR KE+ IRE E +QE I+E EE+
Sbjct: 406 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 465
Query: 87 SSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKR 146
+ EK + + + EK R++E++ R +EE+ R E+ + E+ KI RE KR
Sbjct: 466 IREQEKRQEQEAK-----MWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKI-REEEKR 519
Query: 147 AEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDL----EKEREEKERI 202
EQ E EE I K ++ K++K E + EK +++E+I
Sbjct: 520 QEQEEMWRQEEKIREQEE------IWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKI 573
Query: 203 KYEEDKRIRYE----EQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQR 258
+ +E+K R E EQ ++E + + + E ++ ++E + + K+ +E + Q
Sbjct: 574 REQEEKVWRQEEKIREQEEKIREQE--EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 631
Query: 259 QENRKKQAEEEAR---KRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFE 315
QE + ++ EE+ R K++ E++ E M ++E+ + + + + + +
Sbjct: 632 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE-----KMCEQEEKMQ 686
Query: 316 EMERQRREDEKRKAEEEARRRIEEEK 341
E E + R E++ E+E R R +EEK
Sbjct: 687 EQEEKMRRQEEKMWEQEVRLRQQEEK 712
Score = 72.0 bits (175), Expect = 2e-12
Identities = 89/392 (22%), Positives = 170/392 (43%), Gaps = 61/392 (15%)
Query: 193 EKEREEKERIKYEEDKR----IRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLK 248
EK + +E+++ E ++ + +E + L+ AK L + E++ + L K
Sbjct: 282 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 341
Query: 249 LTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPG 308
L ++E NR Q +EE R EE+ + +EE ++ + E ++ + +
Sbjct: 342 LQ-AQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 400
Query: 309 KLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEF 368
+ ++ +E+ E+ RR++E +EE RR EE E R
Sbjct: 401 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR------------------- 441
Query: 369 LTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLS 428
+LE E K + +EEKR+ EE+ + + + ++QE + RQE E+E +
Sbjct: 442 ----ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI---- 493
Query: 429 REYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAEN 488
RE EE + + EKI + Q+KI EE R+ + E R+ E
Sbjct: 494 REQEE-------------KMWRQEEKIHE------QEKIREEEKRQ---EQEEMWRQEEK 531
Query: 489 FHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREID 548
E++++ R+ E H+ K R +Q K +EE+ +E+K+ + + +
Sbjct: 532 IREQEEI----WRQKEK--IHEQEEKIR-KQEEKMWRQEEKMHDQEEKIREQEEKVWRQE 584
Query: 549 AALQKKREEEEEEEGSIMNGSTAEDEEQTRSG 580
++++ E+ E+E I E++ + G
Sbjct: 585 EKIREQEEKIREQEEKIREQEEMTQEQEEKMG 616
Score = 69.7 bits (169), Expect = 8e-12
Identities = 61/261 (23%), Positives = 129/261 (49%), Gaps = 17/261 (6%)
Query: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE--------IKEMLA 79
K ++K ++ +E+ + ++EK R +E+ IRE+E +QE I+E
Sbjct: 459 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK 518
Query: 80 SDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDML--EKR 137
++E++ + EK + K + E E++ ++++ K +E K +++ + ++
Sbjct: 519 RQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEE 578
Query: 138 KIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKERE 197
K+ R+ K EQ E I + +E + + K + +K E EK R
Sbjct: 579 KVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRR 638
Query: 198 EKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQ 257
++E+I+ E++K+IR +E++ +E ++ + E + ++E + + K+ +E + +
Sbjct: 639 QEEKIR-EQEKKIREQEEKIREQE----EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 693
Query: 258 RQENRKKQAEEEARKRLEEEK 278
RQE +K E+E R R +EEK
Sbjct: 694 RQE--EKMWEQEVRLRQQEEK 712
Score = 63.5 bits (153), Expect = 6e-10
Identities = 102/443 (23%), Positives = 186/443 (41%), Gaps = 45/443 (10%)
Query: 133 MLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLL--ITVVPVKSYKTSGKMKKNFE 190
M+ K Q +LA+ EQ+ D + S D+ I TSG +
Sbjct: 111 MMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPED 170
Query: 191 DLEKEREEKERIKYEEDKRIRYEE----QRPSLKEAKCLSLVMDDEIESEAKKESLSPGK 246
+ + + +E ++ E + ++ Q+ L+ A S ++E EA+ + +S
Sbjct: 171 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR-DLISRLH 229
Query: 247 LKLTFE-ELERQRQE--NRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFK 303
F ELE+ +KK+A+ + +E E R + ++E + AK+ +
Sbjct: 230 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 289
Query: 304 GYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKT 363
KL E E+ E + +E +R++E K + + D E+
Sbjct: 290 -------KLQLVESEKS----EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 338
Query: 364 ISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENE 423
+ KL+ EE ++ + +EE+ + E + QE+E+ QE E+ E E
Sbjct: 339 SA-------KLQAQVEE---NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 388
Query: 424 TFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKE 483
RE EE K++R Q + + K EK+ + E +K+ + R + E K
Sbjct: 389 E--KIREQEE--KMRR----QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 440
Query: 484 REAEN-FHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQ- 541
RE E HE++ + + ++ E + + R EQ AK +EE+ R +E+K+ +
Sbjct: 441 RELEEKMHEQEKIREQEEKRQEEEKIRE--QEKRQEQEAKMWRQEEKIREQEEKIREQEE 498
Query: 542 --FEQREIDAALQKKREEEEEEE 562
+ Q E +K REEE+ +E
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQE 521
Score = 50.1 bits (118), Expect = 7e-06
Identities = 54/272 (19%), Positives = 119/272 (43%), Gaps = 41/272 (15%)
Query: 325 EKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLT----PGKLEINFEE 380
+K+KA+ +E E RN + D++ E + ++ ++++N +E
Sbjct: 248 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 307
Query: 381 LLKQKMEEEKRRTEEER-KHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKR 439
L K+K+E K +++ + + + +E + + ++ + EENE + + +E
Sbjct: 308 L-KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE------ 360
Query: 440 SGSIQAKNLKSKFEKIGQLSEK--EIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDV 497
EK+ + EK E ++KI+E+ + R + +I+E+E +
Sbjct: 361 -------------EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK---------- 397
Query: 498 RPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREE 557
R+ E K R E+M E+EE+ R +E+ + + + RE++ + ++ +
Sbjct: 398 --MRRQEEMMWEKEEKMRRQEEMMW--EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKI 453
Query: 558 EEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLK 589
E+EE E E++ A +++ K
Sbjct: 454 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 485
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 103 bits (257), Expect = 5e-22
Identities = 138/617 (22%), Positives = 263/617 (42%), Gaps = 85/617 (13%)
Query: 25 KLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEE 84
+L + + K +A + A+E Q+R ++E RR+E + ++ R QE + L E
Sbjct: 1374 QLAEAHAQAKAQAEREAKEL--QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431
Query: 85 DVSSKVEKAYVP---KLTGTVKGRFAEMEKQRQEEQRKRTEEER---KRRIEQDMLEKRK 138
++ +K +A +L + R ++ + E QR E E + R E+ +KR+
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 139 IQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE 198
Q E + Q++D + ++ E + ++K + E RE+
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVE-----------------LASRVKA---EAEAAREK 1531
Query: 199 KERIKYEEDKRIRYEEQRPSLKEAKC-LSLVMDDEIESEAKKESLSPGKLKLTFEELERQ 257
+ ++ E+ R++ EE L++A+ + + +E+ + + +F E Q
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1591
Query: 258 RQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEM 317
+ + +++ A+ R E E+RA ++A + E+ E + K +L+L EE+
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1651
Query: 318 ERQR------REDEKRKAEEEARRRIEEEKKAF-------AEARRNMVVDDDSPEMYKTI 364
+Q+ E +K +AE EARRR + E++A E + + + + +
Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1711
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRTEEE------RKHKLEME----KQEFEQLRQE 414
QE + + E E +Q +EEE R + E ++ +LE E + E E L
Sbjct: 1712 EQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 415 MGEEEEENET------------FGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKE 462
EEE+ + G RE E R+ + +AK + E+ E
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 463 IQKKIEEERAR-------RRAIDLEIKEREAENFHEE---DDVDVRPARKSEAPFTHKVN 512
++ + E+ A + ++ +KE+EAEN +D + R E HK +
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 513 MKARFEQMAKAREEEEQRR---IEEQKLLRMQFEQR--EIDAALQKK---REEEEEEEGS 564
++ R Q+ KA + E +R+ +E+ R Q E+ + A+ +K + E E E G
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 565 IMNGSTAEDEEQTRSGA 581
I S AED +++ A
Sbjct: 1951 IR--SNAEDTLRSKEQA 1965
Score = 95.1 bits (235), Expect = 2e-19
Identities = 139/615 (22%), Positives = 256/615 (41%), Gaps = 99/615 (16%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKL 98
+ A ER +R + DE +R+ E + + K +I+E LA K + + +
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRL---EEQAAQHKADIEERLAQ------LRKASDSELERQ 1909
Query: 99 TGTVKGRFAEMEKQRQEEQRKRTEEE---RKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
G V+ QR++ EEE K E+ K +++ EL + ED
Sbjct: 1910 KGLVEDTL---------RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF---EDLEKER----EEKERIK--YEE 206
+ ++ E L + + +++K+ E+ ++R EE ER+K EE
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
+R+R ++ S ++ + +++E K + + + +E E Q+ +++
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQELQQTLQQEQSV 2075
Query: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE- 325
++ R E +RA EEA V + E + + + +LK S EE + R + +
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQA 2133
Query: 326 -----KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEE 380
+++AE+EA RR + E+ A R D E +K + E+
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFA-------------EQ 2176
Query: 381 LLKQKMEEEKRRTE-----EERKHKLEMEKQEFEQLRQEMGE-----EEEENETFGLSRE 430
L+QK + E+ T EE H+ + +E ++L+ E E + E E F + +
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 431 YEELIKLKRSGSIQAKN--------------LKSKFEKIGQLSEKEIQKKI-EEERARRR 475
EEL KLK I+A+N L+ + EK+ Q++E+ + + +E AR R
Sbjct: 2237 MEELSKLK--ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 476 AI---DLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRI 532
+ DL + AE +E V+ A + +A K ++ A+ R +E++ ++
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR-RLQEDKEQM 2353
Query: 533 EEQKLLRMQFEQREIDAALQKKREEEEEEEG--------SIMNGSTAEDEEQTRSGAPWF 584
+Q Q QR ++A Q++ E E E S ED ++ R A
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 585 KKPLKNTSVVDSEPV 599
+ L T + E V
Sbjct: 2414 GEKLHRTELATQEKV 2428
Score = 88.2 bits (217), Expect = 2e-17
Identities = 120/555 (21%), Positives = 241/555 (43%), Gaps = 63/555 (11%)
Query: 36 EAMQRAREERNQRRSRDEKQRR---KEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
+++ +A E+ + + E +RR +EQ +R+RE ++ E + LA + + E+
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-AEQ 1713
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE------RKRRIEQDMLEKR-KIQRELAK 145
+ T +G E ++Q EE+ R + E +++ +E ++ + R +++ LA
Sbjct: 1714 ELIRLRAETEQG---EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 146 RAEQIEDINNTGTESASEEGDDS-----LLITVVPVKSYKTSGKMKKNF--EDLEKEREE 198
+A E+ +T +S ++ L +++ K ++ ED ++R E
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 199 KERIKYE------EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFE 252
ER+ E E R++ E + +LKE + ++ + A+ E+ +L E
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEI-ALKEKEA----ENERLRRLAEDEAFQRRRL----E 1881
Query: 253 ELERQRQ---ENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309
E Q + E R Q + + LE +K E+ RQ +EE F+ GK
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 310 LKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL 369
+L E + ++ +++E+A +++ AE R ++ + +E
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 370 TPGKLEINFEELLKQKMEEEKR---RTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG 426
K + E LK K+EE +R R E+E +L++ ++ Q+ + EE+ F
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA----QEAAQKRLQAEEKAHAFA 2057
Query: 427 LSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREA 486
+ ++ +EL + + L+ + E + +E E E AR +A EREA
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------EAEEARVQA------EREA 2104
Query: 487 ENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE-EQKLLRMQFEQR 545
+ + R + +E + +A E++ K E+E RR + EQ LR +++
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQ 2161
Query: 546 EIDAALQKKREEEEE 560
DA ++K ++ E+
Sbjct: 2162 AADAEMEKHKKFAEQ 2176
Score = 88.2 bits (217), Expect = 2e-17
Identities = 118/561 (21%), Positives = 246/561 (43%), Gaps = 59/561 (10%)
Query: 43 EERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVE-KAYVPKLTGT 101
E RR+ +E + + Q RE +RR+ E E L EE ++ + +A KL
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 102 VKGRFA-----EMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNT 156
+ A E RQ++ E+ K+ EQ + +K ++++EL Q+E+
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2197
Query: 157 GTESASEEGDDSLL-ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQ 215
T+ D+ L + ++ + ++++ + + EE ++K RI E +
Sbjct: 2198 -TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK----ARIEAENR 2252
Query: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA--RKR 273
L++ + +E E + K+ + +L + +E R RQ + A++ A K
Sbjct: 2253 ALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Query: 274 LEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEA 333
L+E+ +A +EA R + Q K +E R+ +ED+++ A++ A
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQ-------------KELAQEQARRLQEDKEQMAQQLA 2358
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--EEKR 391
++ AE +R + + ++ + +++ + E + + KQ E E+
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2418
Query: 392 RTEEERKHK------LEMEKQEF----EQLRQEMGEEEEENETFGLSREYEEL-IKLKRS 440
RTE + K LE+++Q+ E+LR+ + E E E E L +E + L +K +
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--LQQEAKLLQLKSEEM 2476
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPA 500
++Q + L + + + Q E ++ ER +E ++ + E +++ +
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERF------IEQEKAKLEQLFQDEVAKAQQL 2530
Query: 501 RKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE- 559
R+ + + M+ +++ + EE +R+ E ++ +R +Q E+ Q++R++EE
Sbjct: 2531 REEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--KQEELQQLEQQRRQQEEL 2586
Query: 560 -EEEGSIMNGSTAEDEEQTRS 579
EE + EEQ R+
Sbjct: 2587 LAEENQRLREQLQLLEEQHRA 2607
Score = 66.6 bits (161), Expect = 7e-11
Identities = 124/631 (19%), Positives = 245/631 (38%), Gaps = 108/631 (17%)
Query: 3 DISQKAEILLSSSKPVPKTYVPKLG--KGDVKDKFEAMQRAREE-----RNQRRSRDE-- 53
++ + E L ++ VP T +P+L K +K K A A++ R++ R E
Sbjct: 1103 EVLRAHEEQLKEAQAVPAT-LPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVG 1160
Query: 54 ---KQRRKEQYIREREWNRRKQEIKE----MLASDD--EEDVSSKVEKAYVPKLTGTVKG 104
+QR E+ + W R ++ E +LA D + ++ + + + G
Sbjct: 1161 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1220
Query: 105 RFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEE 164
+ + ++RQE+ + + + + + + +++ + E+ + E++E+ + +
Sbjct: 1221 AWLQDARRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1279
Query: 165 GDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKC 224
D L + + + KK E +E + D R Y E
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV----DLRTHYSELT-------- 1327
Query: 225 LSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR-KKQAEEEARKRLEEEKRAFEE 283
+L+ +K E L R +E R +Q E R+RL E + A E+
Sbjct: 1328 ----------------TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA 343
R+ + + + K + E E Q+R E+ EEA +++K++
Sbjct: 1372 QRQ--------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEEL----LKQKMEEEKRRTEEERKH 399
E + + ++ K E +L I EE+ L+ + E +R E
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 400 KLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSI--------QAKNLKSK 451
L +E E +++ EE E L R+ ++ + KR + +A+ + K
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAER-----LRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 452 FEKIGQLSEKEIQ--------KKIEEERARRRAIDLEIKEREAE--------NFHEED-- 493
+ L E +Q ++ E ERAR+ + LE +R AE +F E+
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1591
Query: 494 -DVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKL-------LRMQFEQR 545
+ ++ + A + +A+ + A+ EE +R +E +L LR+Q E+
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1651
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQ 576
+L + E+++EE + EEQ
Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Score = 57.0 bits (136), Expect = 6e-08
Identities = 98/486 (20%), Positives = 208/486 (42%), Gaps = 110/486 (22%)
Query: 33 DKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE----IKEMLASDDEEDVSS 88
++ E ++++ EE+ Q R++ + K + E+E RR Q +++ A+D E +
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 89 KV------EKAYVPKLTGTVKGRFAEMEKQR----QEEQRKR---TEEERKR-------- 127
K +KA V + T++ + E + Q+ +E QR + TE R+R
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231
Query: 128 --RIEQDMLEKRKIQRELAKRAEQIEDINNTG------TESASEEGDDSLLITVVPVKSY 179
R++ + L K K + E RA + D +NT E + +++ ++V ++
Sbjct: 2232 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291
Query: 180 KTSGKMKKNF-------EDLEKER----EEKERIKYE-----EDKRIRYEEQRPSLKEAK 223
+ +++ E + KE+ +E R+K E + K + E+ R ++ +
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 224 CLSLVMDDE-------IESEAKKE---SLSPGKLKLTFEELERQRQ------ENRKKQAE 267
++ + +E +E+E +++ S +LKL E+ R + + +KQAE
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 268 EEA-----------------------RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKG 304
E R++ + + EA ++ E E+ Q AK+
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--- 2468
Query: 305 YRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTI 364
L+L EEM+ ++E ++ + + + E+ +R ++ + ++ +
Sbjct: 2469 -----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL---QRERFIEQEKAKLEQLF 2520
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRT----EEERKHKLEMEK------QEFEQLRQE 414
E +L ++ +Q+ME+E++R EE R+ + E E+ +E +QL Q+
Sbjct: 2521 QDEVAKAQQLREE-QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Query: 415 MGEEEE 420
++EE
Sbjct: 2580 RRQQEE 2585
Score = 53.5 bits (127), Expect = 6e-07
Identities = 87/407 (21%), Positives = 178/407 (43%), Gaps = 59/407 (14%)
Query: 31 VKDKFEAMQRA---REERNQRRSRDEKQRRKEQYIRER-EWNRRKQEIKEM--LASDDEE 84
+K + EA RA R++ N +R E+ + +Q E + QE + LA +D
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 85 DVSSKVEKAYVPKLTGT-------VKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR 137
+ EK K+ + + +K+ +EQ +R +E++++ +Q E +
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 138 KIQREL-AKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKER 196
QR L A+R Q+E SA E + ++ + S + ED ++ R
Sbjct: 2363 GFQRTLEAERQRQLE-------MSAEAER--------LKLRVAEMSRAQARAEEDAQRFR 2407
Query: 197 EEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELER 256
++ E I + R L + ++LV EI+ + +L+ ELER
Sbjct: 2408 KQAEEIGEKL--------HRTELATQEKVTLVQTLEIQRQQSDHDAE--RLREAIAELER 2457
Query: 257 QRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEE 316
+++ K Q E + + EE Q V +++ Q+T + + + K L
Sbjct: 2458 EKE---KLQQEAKLLQLKSEEM--------QTVQQEQLLQETQALQQSFLSEKDSL---- 2502
Query: 317 MERQRR-EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE 375
++R+R E EK K E+ + + + ++ E +R + + +E + +
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQ 2559
Query: 376 INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEEN 422
EE +++K +EE ++ E++R+ + E+ +E ++LR+++ EE++
Sbjct: 2560 HEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Score = 33.9 bits (76), Expect = 0.50
Identities = 64/281 (22%), Positives = 112/281 (39%), Gaps = 67/281 (23%)
Query: 318 ERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE-- 375
E +R E++KA+ E + + AEA + + + + SP S+ LT GKLE
Sbjct: 1018 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1077
Query: 376 -----INFEELL--------KQKMEEEKRRTEEERKH---------KLEMEKQEFEQLRQ 413
I E+L Q EE R EE+ K +LE K ++LR
Sbjct: 1078 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR- 1136
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERAR 473
+ E + TF R+ L+ E +L ++ ++ +E ER R
Sbjct: 1137 --AQAEAQQPTFDALRD----------------ELRGAQEVGERLQQRHGERDVEVERWR 1178
Query: 474 RRAIDL-----------EIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
R L ++++RE E + +R R+S P + A + +
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQ----LRYYRESADP------LGAWLQDARR 1228
Query: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQK-KREEEEEEE 562
+E+ + + + + +R Q Q + A L++ +R E+ EE
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQ--ALLEEIERHGEKVEE 1267
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 103 bits (257), Expect = 5e-22
Identities = 138/617 (22%), Positives = 263/617 (42%), Gaps = 85/617 (13%)
Query: 25 KLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEE 84
+L + + K +A + A+E Q+R ++E RR+E + ++ R QE + L E
Sbjct: 1378 QLAEAHAQAKAQAEREAKEL--QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1435
Query: 85 DVSSKVEKAYVP---KLTGTVKGRFAEMEKQRQEEQRKRTEEER---KRRIEQDMLEKRK 138
++ +K +A +L + R ++ + E QR E E + R E+ +KR+
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495
Query: 139 IQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE 198
Q E + Q++D + ++ E + ++K + E RE+
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVE-----------------LASRVKA---EAEAAREK 1535
Query: 199 KERIKYEEDKRIRYEEQRPSLKEAKC-LSLVMDDEIESEAKKESLSPGKLKLTFEELERQ 257
+ ++ E+ R++ EE L++A+ + + +E+ + + +F E Q
Sbjct: 1536 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1595
Query: 258 RQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEM 317
+ + +++ A+ R E E+RA ++A + E+ E + K +L+L EE+
Sbjct: 1596 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1655
Query: 318 ERQR------REDEKRKAEEEARRRIEEEKKAF-------AEARRNMVVDDDSPEMYKTI 364
+Q+ E +K +AE EARRR + E++A E + + + + +
Sbjct: 1656 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1715
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRTEEE------RKHKLEME----KQEFEQLRQE 414
QE + + E E +Q +EEE R + E ++ +LE E + E E L
Sbjct: 1716 EQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1774
Query: 415 MGEEEEENET------------FGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKE 462
EEE+ + G RE E R+ + +AK + E+ E
Sbjct: 1775 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834
Query: 463 IQKKIEEERAR-------RRAIDLEIKEREAENFHEE---DDVDVRPARKSEAPFTHKVN 512
++ + E+ A + ++ +KE+EAEN +D + R E HK +
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894
Query: 513 MKARFEQMAKAREEEEQRR---IEEQKLLRMQFEQR--EIDAALQKK---REEEEEEEGS 564
++ R Q+ KA + E +R+ +E+ R Q E+ + A+ +K + E E E G
Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954
Query: 565 IMNGSTAEDEEQTRSGA 581
I S AED +++ A
Sbjct: 1955 IR--SNAEDTLRSKEQA 1969
Score = 95.1 bits (235), Expect = 2e-19
Identities = 139/615 (22%), Positives = 256/615 (41%), Gaps = 99/615 (16%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKL 98
+ A ER +R + DE +R+ E + + K +I+E LA K + + +
Sbjct: 1863 KEAENERLRRLAEDEAFQRRRL---EEQAAQHKADIEERLAQ------LRKASDSELERQ 1913
Query: 99 TGTVKGRFAEMEKQRQEEQRKRTEEE---RKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
G V+ QR++ EEE K E+ K +++ EL + ED
Sbjct: 1914 KGLVEDTL---------RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF---EDLEKER----EEKERIK--YEE 206
+ ++ E L + + +++K+ E+ ++R EE ER+K EE
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2024
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
+R+R ++ S ++ + +++E K + + + +E E Q+ +++
Sbjct: 2025 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQELQQTLQQEQSV 2079
Query: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE- 325
++ R E +RA EEA V + E + + + +LK S EE + R + +
Sbjct: 2080 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQA 2137
Query: 326 -----KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEE 380
+++AE+EA RR + E+ A R D E +K + E+
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFA-------------EQ 2180
Query: 381 LLKQKMEEEKRRTE-----EERKHKLEMEKQEFEQLRQEMGE-----EEEENETFGLSRE 430
L+QK + E+ T EE H+ + +E ++L+ E E + E E F + +
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 431 YEELIKLKRSGSIQAKN--------------LKSKFEKIGQLSEKEIQKKI-EEERARRR 475
EEL KLK I+A+N L+ + EK+ Q++E+ + + +E AR R
Sbjct: 2241 MEELSKLK--ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298
Query: 476 AI---DLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRI 532
+ DL + AE +E V+ A + +A K ++ A+ R +E++ ++
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR-RLQEDKEQM 2357
Query: 533 EEQKLLRMQFEQREIDAALQKKREEEEEEEG--------SIMNGSTAEDEEQTRSGAPWF 584
+Q Q QR ++A Q++ E E E S ED ++ R A
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2417
Query: 585 KKPLKNTSVVDSEPV 599
+ L T + E V
Sbjct: 2418 GEKLHRTELATQEKV 2432
Score = 88.2 bits (217), Expect = 2e-17
Identities = 120/555 (21%), Positives = 241/555 (43%), Gaps = 63/555 (11%)
Query: 36 EAMQRAREERNQRRSRDEKQRR---KEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
+++ +A E+ + + E +RR +EQ +R+RE ++ E + LA + + E+
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-AEQ 1717
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE------RKRRIEQDMLEKR-KIQRELAK 145
+ T +G E ++Q EE+ R + E +++ +E ++ + R +++ LA
Sbjct: 1718 ELIRLRAETEQG---EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1774
Query: 146 RAEQIEDINNTGTESASEEGDDS-----LLITVVPVKSYKTSGKMKKNF--EDLEKEREE 198
+A E+ +T +S ++ L +++ K ++ ED ++R E
Sbjct: 1775 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834
Query: 199 KERIKYE------EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFE 252
ER+ E E R++ E + +LKE + ++ + A+ E+ +L E
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEI-ALKEKEA----ENERLRRLAEDEAFQRRRL----E 1885
Query: 253 ELERQRQ---ENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309
E Q + E R Q + + LE +K E+ RQ +EE F+ GK
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1945
Query: 310 LKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL 369
+L E + ++ +++E+A +++ AE R ++ + +E
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005
Query: 370 TPGKLEINFEELLKQKMEEEKR---RTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG 426
K + E LK K+EE +R R E+E +L++ ++ Q+ + EE+ F
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA----QEAAQKRLQAEEKAHAFA 2061
Query: 427 LSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREA 486
+ ++ +EL + + L+ + E + +E E E AR +A EREA
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------EAEEARVQA------EREA 2108
Query: 487 ENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE-EQKLLRMQFEQR 545
+ + R + +E + +A E++ K E+E RR + EQ LR +++
Sbjct: 2109 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQ 2165
Query: 546 EIDAALQKKREEEEE 560
DA ++K ++ E+
Sbjct: 2166 AADAEMEKHKKFAEQ 2180
Score = 88.2 bits (217), Expect = 2e-17
Identities = 118/561 (21%), Positives = 246/561 (43%), Gaps = 59/561 (10%)
Query: 43 EERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVE-KAYVPKLTGT 101
E RR+ +E + + Q RE +RR+ E E L EE ++ + +A KL
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145
Query: 102 VKGRFA-----EMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNT 156
+ A E RQ++ E+ K+ EQ + +K ++++EL Q+E+
Sbjct: 2146 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2201
Query: 157 GTESASEEGDDSLL-ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQ 215
T+ D+ L + ++ + ++++ + + EE ++K RI E +
Sbjct: 2202 -TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK----ARIEAENR 2256
Query: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA--RKR 273
L++ + +E E + K+ + +L + +E R RQ + A++ A K
Sbjct: 2257 ALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315
Query: 274 LEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEA 333
L+E+ +A +EA R + Q K +E R+ +ED+++ A++ A
Sbjct: 2316 LKEKMQAVQEATRLKAEAELLQQQ-------------KELAQEQARRLQEDKEQMAQQLA 2362
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--EEKR 391
++ AE +R + + ++ + +++ + E + + KQ E E+
Sbjct: 2363 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2422
Query: 392 RTEEERKHK------LEMEKQEF----EQLRQEMGEEEEENETFGLSREYEEL-IKLKRS 440
RTE + K LE+++Q+ E+LR+ + E E E E L +E + L +K +
Sbjct: 2423 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--LQQEAKLLQLKSEEM 2480
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPA 500
++Q + L + + + Q E ++ ER +E ++ + E +++ +
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERF------IEQEKAKLEQLFQDEVAKAQQL 2534
Query: 501 RKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE- 559
R+ + + M+ +++ + EE +R+ E ++ +R +Q E+ Q++R++EE
Sbjct: 2535 REEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--KQEELQQLEQQRRQQEEL 2590
Query: 560 -EEEGSIMNGSTAEDEEQTRS 579
EE + EEQ R+
Sbjct: 2591 LAEENQRLREQLQLLEEQHRA 2611
Score = 66.6 bits (161), Expect = 7e-11
Identities = 124/631 (19%), Positives = 245/631 (38%), Gaps = 108/631 (17%)
Query: 3 DISQKAEILLSSSKPVPKTYVPKLG--KGDVKDKFEAMQRAREE-----RNQRRSRDE-- 53
++ + E L ++ VP T +P+L K +K K A A++ R++ R E
Sbjct: 1107 EVLRAHEEQLKEAQAVPAT-LPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVG 1164
Query: 54 ---KQRRKEQYIREREWNRRKQEIKE----MLASDD--EEDVSSKVEKAYVPKLTGTVKG 104
+QR E+ + W R ++ E +LA D + ++ + + + G
Sbjct: 1165 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1224
Query: 105 RFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEE 164
+ + ++RQE+ + + + + + + +++ + E+ + E++E+ + +
Sbjct: 1225 AWLQDARRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1283
Query: 165 GDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKC 224
D L + + + KK E +E + D R Y E
Sbjct: 1284 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV----DLRTHYSELT-------- 1331
Query: 225 LSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR-KKQAEEEARKRLEEEKRAFEE 283
+L+ +K E L R +E R +Q E R+RL E + A E+
Sbjct: 1332 ----------------TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1375
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA 343
R+ + + + K + E E Q+R E+ EEA +++K++
Sbjct: 1376 QRQ--------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1421
Query: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEEL----LKQKMEEEKRRTEEERKH 399
E + + ++ K E +L I EE+ L+ + E +R E
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQ 1480
Query: 400 KLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSI--------QAKNLKSK 451
L +E E +++ EE E L R+ ++ + KR + +A+ + K
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAER-----LRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1535
Query: 452 FEKIGQLSEKEIQ--------KKIEEERARRRAIDLEIKEREAE--------NFHEED-- 493
+ L E +Q ++ E ERAR+ + LE +R AE +F E+
Sbjct: 1536 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1595
Query: 494 -DVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKL-------LRMQFEQR 545
+ ++ + A + +A+ + A+ EE +R +E +L LR+Q E+
Sbjct: 1596 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1655
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQ 576
+L + E+++EE + EEQ
Sbjct: 1656 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1686
Score = 57.0 bits (136), Expect = 6e-08
Identities = 98/486 (20%), Positives = 208/486 (42%), Gaps = 110/486 (22%)
Query: 33 DKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE----IKEMLASDDEEDVSS 88
++ E ++++ EE+ Q R++ + K + E+E RR Q +++ A+D E +
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175
Query: 89 KV------EKAYVPKLTGTVKGRFAEMEKQR----QEEQRKR---TEEERKR-------- 127
K +KA V + T++ + E + Q+ +E QR + TE R+R
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2235
Query: 128 --RIEQDMLEKRKIQRELAKRAEQIEDINNTG------TESASEEGDDSLLITVVPVKSY 179
R++ + L K K + E RA + D +NT E + +++ ++V ++
Sbjct: 2236 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2295
Query: 180 KTSGKMKKNF-------EDLEKER----EEKERIKYE-----EDKRIRYEEQRPSLKEAK 223
+ +++ E + KE+ +E R+K E + K + E+ R ++ +
Sbjct: 2296 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2355
Query: 224 CLSLVMDDE-------IESEAKKE---SLSPGKLKLTFEELERQRQ------ENRKKQAE 267
++ + +E +E+E +++ S +LKL E+ R + + +KQAE
Sbjct: 2356 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2415
Query: 268 EEA-----------------------RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKG 304
E R++ + + EA ++ E E+ Q AK+
Sbjct: 2416 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--- 2472
Query: 305 YRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTI 364
L+L EEM+ ++E ++ + + + E+ +R ++ + ++ +
Sbjct: 2473 -----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL---QRERFIEQEKAKLEQLF 2524
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRT----EEERKHKLEMEK------QEFEQLRQE 414
E +L ++ +Q+ME+E++R EE R+ + E E+ +E +QL Q+
Sbjct: 2525 QDEVAKAQQLREE-QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2583
Query: 415 MGEEEE 420
++EE
Sbjct: 2584 RRQQEE 2589
Score = 53.5 bits (127), Expect = 6e-07
Identities = 87/407 (21%), Positives = 178/407 (43%), Gaps = 59/407 (14%)
Query: 31 VKDKFEAMQRA---REERNQRRSRDEKQRRKEQYIRER-EWNRRKQEIKEM--LASDDEE 84
+K + EA RA R++ N +R E+ + +Q E + QE + LA +D
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2306
Query: 85 DVSSKVEKAYVPKLTGT-------VKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR 137
+ EK K+ + + +K+ +EQ +R +E++++ +Q E +
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 138 KIQREL-AKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKER 196
QR L A+R Q+E SA E + ++ + S + ED ++ R
Sbjct: 2367 GFQRTLEAERQRQLE-------MSAEAER--------LKLRVAEMSRAQARAEEDAQRFR 2411
Query: 197 EEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELER 256
++ E I + R L + ++LV EI+ + +L+ ELER
Sbjct: 2412 KQAEEIGEKL--------HRTELATQEKVTLVQTLEIQRQQSDHDAE--RLREAIAELER 2461
Query: 257 QRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEE 316
+++ K Q E + + EE Q V +++ Q+T + + + K L
Sbjct: 2462 EKE---KLQQEAKLLQLKSEEM--------QTVQQEQLLQETQALQQSFLSEKDSL---- 2506
Query: 317 MERQRR-EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE 375
++R+R E EK K E+ + + + ++ E +R + + +E + +
Sbjct: 2507 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQ 2563
Query: 376 INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEEN 422
EE +++K +EE ++ E++R+ + E+ +E ++LR+++ EE++
Sbjct: 2564 HEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2609
Score = 33.9 bits (76), Expect = 0.50
Identities = 64/281 (22%), Positives = 112/281 (39%), Gaps = 67/281 (23%)
Query: 318 ERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE-- 375
E +R E++KA+ E + + AEA + + + + SP S+ LT GKLE
Sbjct: 1022 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1081
Query: 376 -----INFEELL--------KQKMEEEKRRTEEERKH---------KLEMEKQEFEQLRQ 413
I E+L Q EE R EE+ K +LE K ++LR
Sbjct: 1082 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR- 1140
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERAR 473
+ E + TF R+ L+ E +L ++ ++ +E ER R
Sbjct: 1141 --AQAEAQQPTFDALRD----------------ELRGAQEVGERLQQRHGERDVEVERWR 1182
Query: 474 RRAIDL-----------EIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
R L ++++RE E + +R R+S P + A + +
Sbjct: 1183 ERVAQLLERWQAVLAQTDVRQRELEQLGRQ----LRYYRESADP------LGAWLQDARR 1232
Query: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQK-KREEEEEEE 562
+E+ + + + + +R Q Q + A L++ +R E+ EE
Sbjct: 1233 RQEQIQAMPLADSQAVREQLRQEQ--ALLEEIERHGEKVEE 1271
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 103 bits (257), Expect = 5e-22
Identities = 138/617 (22%), Positives = 263/617 (42%), Gaps = 85/617 (13%)
Query: 25 KLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEE 84
+L + + K +A + A+E Q+R ++E RR+E + ++ R QE + L E
Sbjct: 1374 QLAEAHAQAKAQAEREAKEL--QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431
Query: 85 DVSSKVEKAYVP---KLTGTVKGRFAEMEKQRQEEQRKRTEEER---KRRIEQDMLEKRK 138
++ +K +A +L + R ++ + E QR E E + R E+ +KR+
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 139 IQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE 198
Q E + Q++D + ++ E + ++K + E RE+
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVE-----------------LASRVKA---EAEAAREK 1531
Query: 199 KERIKYEEDKRIRYEEQRPSLKEAKC-LSLVMDDEIESEAKKESLSPGKLKLTFEELERQ 257
+ ++ E+ R++ EE L++A+ + + +E+ + + +F E Q
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1591
Query: 258 RQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEM 317
+ + +++ A+ R E E+RA ++A + E+ E + K +L+L EE+
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1651
Query: 318 ERQR------REDEKRKAEEEARRRIEEEKKAF-------AEARRNMVVDDDSPEMYKTI 364
+Q+ E +K +AE EARRR + E++A E + + + + +
Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1711
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRTEEE------RKHKLEME----KQEFEQLRQE 414
QE + + E E +Q +EEE R + E ++ +LE E + E E L
Sbjct: 1712 EQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 415 MGEEEEENET------------FGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKE 462
EEE+ + G RE E R+ + +AK + E+ E
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 463 IQKKIEEERAR-------RRAIDLEIKEREAENFHEE---DDVDVRPARKSEAPFTHKVN 512
++ + E+ A + ++ +KE+EAEN +D + R E HK +
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 513 MKARFEQMAKAREEEEQRR---IEEQKLLRMQFEQR--EIDAALQKK---REEEEEEEGS 564
++ R Q+ KA + E +R+ +E+ R Q E+ + A+ +K + E E E G
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 565 IMNGSTAEDEEQTRSGA 581
I S AED +++ A
Sbjct: 1951 IR--SNAEDTLRSKEQA 1965
Score = 95.1 bits (235), Expect = 2e-19
Identities = 139/615 (22%), Positives = 256/615 (41%), Gaps = 99/615 (16%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKL 98
+ A ER +R + DE +R+ E + + K +I+E LA K + + +
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRL---EEQAAQHKADIEERLAQ------LRKASDSELERQ 1909
Query: 99 TGTVKGRFAEMEKQRQEEQRKRTEEE---RKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
G V+ QR++ EEE K E+ K +++ EL + ED
Sbjct: 1910 KGLVEDTL---------RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF---EDLEKER----EEKERIK--YEE 206
+ ++ E L + + +++K+ E+ ++R EE ER+K EE
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
+R+R ++ S ++ + +++E K + + + +E E Q+ +++
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQELQQTLQQEQSV 2075
Query: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE- 325
++ R E +RA EEA V + E + + + +LK S EE + R + +
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQA 2133
Query: 326 -----KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEE 380
+++AE+EA RR + E+ A R D E +K + E+
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFA-------------EQ 2176
Query: 381 LLKQKMEEEKRRTE-----EERKHKLEMEKQEFEQLRQEMGE-----EEEENETFGLSRE 430
L+QK + E+ T EE H+ + +E ++L+ E E + E E F + +
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 431 YEELIKLKRSGSIQAKN--------------LKSKFEKIGQLSEKEIQKKI-EEERARRR 475
EEL KLK I+A+N L+ + EK+ Q++E+ + + +E AR R
Sbjct: 2237 MEELSKLK--ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 476 AI---DLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRI 532
+ DL + AE +E V+ A + +A K ++ A+ R +E++ ++
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR-RLQEDKEQM 2353
Query: 533 EEQKLLRMQFEQREIDAALQKKREEEEEEEG--------SIMNGSTAEDEEQTRSGAPWF 584
+Q Q QR ++A Q++ E E E S ED ++ R A
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 585 KKPLKNTSVVDSEPV 599
+ L T + E V
Sbjct: 2414 GEKLHRTELATQEKV 2428
Score = 88.2 bits (217), Expect = 2e-17
Identities = 120/555 (21%), Positives = 241/555 (43%), Gaps = 63/555 (11%)
Query: 36 EAMQRAREERNQRRSRDEKQRR---KEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
+++ +A E+ + + E +RR +EQ +R+RE ++ E + LA + + E+
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-AEQ 1713
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE------RKRRIEQDMLEKR-KIQRELAK 145
+ T +G E ++Q EE+ R + E +++ +E ++ + R +++ LA
Sbjct: 1714 ELIRLRAETEQG---EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 146 RAEQIEDINNTGTESASEEGDDS-----LLITVVPVKSYKTSGKMKKNF--EDLEKEREE 198
+A E+ +T +S ++ L +++ K ++ ED ++R E
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 199 KERIKYE------EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFE 252
ER+ E E R++ E + +LKE + ++ + A+ E+ +L E
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEI-ALKEKEA----ENERLRRLAEDEAFQRRRL----E 1881
Query: 253 ELERQRQ---ENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309
E Q + E R Q + + LE +K E+ RQ +EE F+ GK
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 310 LKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL 369
+L E + ++ +++E+A +++ AE R ++ + +E
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 370 TPGKLEINFEELLKQKMEEEKR---RTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG 426
K + E LK K+EE +R R E+E +L++ ++ Q+ + EE+ F
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA----QEAAQKRLQAEEKAHAFA 2057
Query: 427 LSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREA 486
+ ++ +EL + + L+ + E + +E E E AR +A EREA
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------EAEEARVQA------EREA 2104
Query: 487 ENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE-EQKLLRMQFEQR 545
+ + R + +E + +A E++ K E+E RR + EQ LR +++
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQ 2161
Query: 546 EIDAALQKKREEEEE 560
DA ++K ++ E+
Sbjct: 2162 AADAEMEKHKKFAEQ 2176
Score = 88.2 bits (217), Expect = 2e-17
Identities = 118/561 (21%), Positives = 246/561 (43%), Gaps = 59/561 (10%)
Query: 43 EERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVE-KAYVPKLTGT 101
E RR+ +E + + Q RE +RR+ E E L EE ++ + +A KL
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 102 VKGRFA-----EMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNT 156
+ A E RQ++ E+ K+ EQ + +K ++++EL Q+E+
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2197
Query: 157 GTESASEEGDDSLL-ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQ 215
T+ D+ L + ++ + ++++ + + EE ++K RI E +
Sbjct: 2198 -TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK----ARIEAENR 2252
Query: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA--RKR 273
L++ + +E E + K+ + +L + +E R RQ + A++ A K
Sbjct: 2253 ALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Query: 274 LEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEA 333
L+E+ +A +EA R + Q K +E R+ +ED+++ A++ A
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQ-------------KELAQEQARRLQEDKEQMAQQLA 2358
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--EEKR 391
++ AE +R + + ++ + +++ + E + + KQ E E+
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2418
Query: 392 RTEEERKHK------LEMEKQEF----EQLRQEMGEEEEENETFGLSREYEEL-IKLKRS 440
RTE + K LE+++Q+ E+LR+ + E E E E L +E + L +K +
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--LQQEAKLLQLKSEEM 2476
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPA 500
++Q + L + + + Q E ++ ER +E ++ + E +++ +
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERF------IEQEKAKLEQLFQDEVAKAQQL 2530
Query: 501 RKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE- 559
R+ + + M+ +++ + EE +R+ E ++ +R +Q E+ Q++R++EE
Sbjct: 2531 REEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--KQEELQQLEQQRRQQEEL 2586
Query: 560 -EEEGSIMNGSTAEDEEQTRS 579
EE + EEQ R+
Sbjct: 2587 LAEENQRLREQLQLLEEQHRA 2607
Score = 66.6 bits (161), Expect = 7e-11
Identities = 124/631 (19%), Positives = 245/631 (38%), Gaps = 108/631 (17%)
Query: 3 DISQKAEILLSSSKPVPKTYVPKLG--KGDVKDKFEAMQRAREE-----RNQRRSRDE-- 53
++ + E L ++ VP T +P+L K +K K A A++ R++ R E
Sbjct: 1103 EVLRAHEEQLKEAQAVPAT-LPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVG 1160
Query: 54 ---KQRRKEQYIREREWNRRKQEIKE----MLASDD--EEDVSSKVEKAYVPKLTGTVKG 104
+QR E+ + W R ++ E +LA D + ++ + + + G
Sbjct: 1161 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1220
Query: 105 RFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEE 164
+ + ++RQE+ + + + + + + +++ + E+ + E++E+ + +
Sbjct: 1221 AWLQDARRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1279
Query: 165 GDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKC 224
D L + + + KK E +E + D R Y E
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV----DLRTHYSELT-------- 1327
Query: 225 LSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR-KKQAEEEARKRLEEEKRAFEE 283
+L+ +K E L R +E R +Q E R+RL E + A E+
Sbjct: 1328 ----------------TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA 343
R+ + + + K + E E Q+R E+ EEA +++K++
Sbjct: 1372 QRQ--------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEEL----LKQKMEEEKRRTEEERKH 399
E + + ++ K E +L I EE+ L+ + E +R E
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 400 KLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSI--------QAKNLKSK 451
L +E E +++ EE E L R+ ++ + KR + +A+ + K
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAER-----LRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 452 FEKIGQLSEKEIQ--------KKIEEERARRRAIDLEIKEREAE--------NFHEED-- 493
+ L E +Q ++ E ERAR+ + LE +R AE +F E+
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1591
Query: 494 -DVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKL-------LRMQFEQR 545
+ ++ + A + +A+ + A+ EE +R +E +L LR+Q E+
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1651
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQ 576
+L + E+++EE + EEQ
Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Score = 57.0 bits (136), Expect = 6e-08
Identities = 98/486 (20%), Positives = 208/486 (42%), Gaps = 110/486 (22%)
Query: 33 DKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE----IKEMLASDDEEDVSS 88
++ E ++++ EE+ Q R++ + K + E+E RR Q +++ A+D E +
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 89 KV------EKAYVPKLTGTVKGRFAEMEKQR----QEEQRKR---TEEERKR-------- 127
K +KA V + T++ + E + Q+ +E QR + TE R+R
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231
Query: 128 --RIEQDMLEKRKIQRELAKRAEQIEDINNTG------TESASEEGDDSLLITVVPVKSY 179
R++ + L K K + E RA + D +NT E + +++ ++V ++
Sbjct: 2232 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291
Query: 180 KTSGKMKKNF-------EDLEKER----EEKERIKYE-----EDKRIRYEEQRPSLKEAK 223
+ +++ E + KE+ +E R+K E + K + E+ R ++ +
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 224 CLSLVMDDE-------IESEAKKE---SLSPGKLKLTFEELERQRQ------ENRKKQAE 267
++ + +E +E+E +++ S +LKL E+ R + + +KQAE
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 268 EEA-----------------------RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKG 304
E R++ + + EA ++ E E+ Q AK+
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--- 2468
Query: 305 YRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTI 364
L+L EEM+ ++E ++ + + + E+ +R ++ + ++ +
Sbjct: 2469 -----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL---QRERFIEQEKAKLEQLF 2520
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRT----EEERKHKLEMEK------QEFEQLRQE 414
E +L ++ +Q+ME+E++R EE R+ + E E+ +E +QL Q+
Sbjct: 2521 QDEVAKAQQLREE-QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Query: 415 MGEEEE 420
++EE
Sbjct: 2580 RRQQEE 2585
Score = 53.5 bits (127), Expect = 6e-07
Identities = 87/407 (21%), Positives = 178/407 (43%), Gaps = 59/407 (14%)
Query: 31 VKDKFEAMQRA---REERNQRRSRDEKQRRKEQYIRER-EWNRRKQEIKEM--LASDDEE 84
+K + EA RA R++ N +R E+ + +Q E + QE + LA +D
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 85 DVSSKVEKAYVPKLTGT-------VKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR 137
+ EK K+ + + +K+ +EQ +R +E++++ +Q E +
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 138 KIQREL-AKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKER 196
QR L A+R Q+E SA E + ++ + S + ED ++ R
Sbjct: 2363 GFQRTLEAERQRQLE-------MSAEAER--------LKLRVAEMSRAQARAEEDAQRFR 2407
Query: 197 EEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELER 256
++ E I + R L + ++LV EI+ + +L+ ELER
Sbjct: 2408 KQAEEIGEKL--------HRTELATQEKVTLVQTLEIQRQQSDHDAE--RLREAIAELER 2457
Query: 257 QRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEE 316
+++ K Q E + + EE Q V +++ Q+T + + + K L
Sbjct: 2458 EKE---KLQQEAKLLQLKSEEM--------QTVQQEQLLQETQALQQSFLSEKDSL---- 2502
Query: 317 MERQRR-EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE 375
++R+R E EK K E+ + + + ++ E +R + + +E + +
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQ 2559
Query: 376 INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEEN 422
EE +++K +EE ++ E++R+ + E+ +E ++LR+++ EE++
Sbjct: 2560 HEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Score = 33.9 bits (76), Expect = 0.50
Identities = 64/281 (22%), Positives = 112/281 (39%), Gaps = 67/281 (23%)
Query: 318 ERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE-- 375
E +R E++KA+ E + + AEA + + + + SP S+ LT GKLE
Sbjct: 1018 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1077
Query: 376 -----INFEELL--------KQKMEEEKRRTEEERKH---------KLEMEKQEFEQLRQ 413
I E+L Q EE R EE+ K +LE K ++LR
Sbjct: 1078 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR- 1136
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERAR 473
+ E + TF R+ L+ E +L ++ ++ +E ER R
Sbjct: 1137 --AQAEAQQPTFDALRD----------------ELRGAQEVGERLQQRHGERDVEVERWR 1178
Query: 474 RRAIDL-----------EIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
R L ++++RE E + +R R+S P + A + +
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQ----LRYYRESADP------LGAWLQDARR 1228
Query: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQK-KREEEEEEE 562
+E+ + + + + +R Q Q + A L++ +R E+ EE
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQ--ALLEEIERHGEKVEE 1267
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 103 bits (257), Expect = 5e-22
Identities = 138/617 (22%), Positives = 263/617 (42%), Gaps = 85/617 (13%)
Query: 25 KLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEE 84
+L + + K +A + A+E Q+R ++E RR+E + ++ R QE + L E
Sbjct: 1342 QLAEAHAQAKAQAEREAKEL--QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1399
Query: 85 DVSSKVEKAYVP---KLTGTVKGRFAEMEKQRQEEQRKRTEEER---KRRIEQDMLEKRK 138
++ +K +A +L + R ++ + E QR E E + R E+ +KR+
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459
Query: 139 IQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE 198
Q E + Q++D + ++ E + ++K + E RE+
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVE-----------------LASRVKA---EAEAAREK 1499
Query: 199 KERIKYEEDKRIRYEEQRPSLKEAKC-LSLVMDDEIESEAKKESLSPGKLKLTFEELERQ 257
+ ++ E+ R++ EE L++A+ + + +E+ + + +F E Q
Sbjct: 1500 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1559
Query: 258 RQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEM 317
+ + +++ A+ R E E+RA ++A + E+ E + K +L+L EE+
Sbjct: 1560 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1619
Query: 318 ERQR------REDEKRKAEEEARRRIEEEKKAF-------AEARRNMVVDDDSPEMYKTI 364
+Q+ E +K +AE EARRR + E++A E + + + + +
Sbjct: 1620 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1679
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRTEEE------RKHKLEME----KQEFEQLRQE 414
QE + + E E +Q +EEE R + E ++ +LE E + E E L
Sbjct: 1680 EQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1738
Query: 415 MGEEEEENET------------FGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKE 462
EEE+ + G RE E R+ + +AK + E+ E
Sbjct: 1739 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798
Query: 463 IQKKIEEERAR-------RRAIDLEIKEREAENFHEE---DDVDVRPARKSEAPFTHKVN 512
++ + E+ A + ++ +KE+EAEN +D + R E HK +
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858
Query: 513 MKARFEQMAKAREEEEQRR---IEEQKLLRMQFEQR--EIDAALQKK---REEEEEEEGS 564
++ R Q+ KA + E +R+ +E+ R Q E+ + A+ +K + E E E G
Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918
Query: 565 IMNGSTAEDEEQTRSGA 581
I S AED +++ A
Sbjct: 1919 IR--SNAEDTLRSKEQA 1933
Score = 95.1 bits (235), Expect = 2e-19
Identities = 139/615 (22%), Positives = 256/615 (41%), Gaps = 99/615 (16%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKL 98
+ A ER +R + DE +R+ E + + K +I+E LA K + + +
Sbjct: 1827 KEAENERLRRLAEDEAFQRRRL---EEQAAQHKADIEERLAQ------LRKASDSELERQ 1877
Query: 99 TGTVKGRFAEMEKQRQEEQRKRTEEE---RKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
G V+ QR++ EEE K E+ K +++ EL + ED
Sbjct: 1878 KGLVEDTL---------RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF---EDLEKER----EEKERIK--YEE 206
+ ++ E L + + +++K+ E+ ++R EE ER+K EE
Sbjct: 1929 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1988
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
+R+R ++ S ++ + +++E K + + + +E E Q+ +++
Sbjct: 1989 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQELQQTLQQEQSV 2043
Query: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE- 325
++ R E +RA EEA V + E + + + +LK S EE + R + +
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQA 2101
Query: 326 -----KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEE 380
+++AE+EA RR + E+ A R D E +K + E+
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFA-------------EQ 2144
Query: 381 LLKQKMEEEKRRTE-----EERKHKLEMEKQEFEQLRQEMGE-----EEEENETFGLSRE 430
L+QK + E+ T EE H+ + +E ++L+ E E + E E F + +
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 431 YEELIKLKRSGSIQAKN--------------LKSKFEKIGQLSEKEIQKKI-EEERARRR 475
EEL KLK I+A+N L+ + EK+ Q++E+ + + +E AR R
Sbjct: 2205 MEELSKLK--ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262
Query: 476 AI---DLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRI 532
+ DL + AE +E V+ A + +A K ++ A+ R +E++ ++
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR-RLQEDKEQM 2321
Query: 533 EEQKLLRMQFEQREIDAALQKKREEEEEEEG--------SIMNGSTAEDEEQTRSGAPWF 584
+Q Q QR ++A Q++ E E E S ED ++ R A
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2381
Query: 585 KKPLKNTSVVDSEPV 599
+ L T + E V
Sbjct: 2382 GEKLHRTELATQEKV 2396
Score = 88.2 bits (217), Expect = 2e-17
Identities = 120/555 (21%), Positives = 241/555 (43%), Gaps = 63/555 (11%)
Query: 36 EAMQRAREERNQRRSRDEKQRR---KEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
+++ +A E+ + + E +RR +EQ +R+RE ++ E + LA + + E+
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-AEQ 1681
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE------RKRRIEQDMLEKR-KIQRELAK 145
+ T +G E ++Q EE+ R + E +++ +E ++ + R +++ LA
Sbjct: 1682 ELIRLRAETEQG---EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1738
Query: 146 RAEQIEDINNTGTESASEEGDDS-----LLITVVPVKSYKTSGKMKKNF--EDLEKEREE 198
+A E+ +T +S ++ L +++ K ++ ED ++R E
Sbjct: 1739 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798
Query: 199 KERIKYE------EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFE 252
ER+ E E R++ E + +LKE + ++ + A+ E+ +L E
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEI-ALKEKEA----ENERLRRLAEDEAFQRRRL----E 1849
Query: 253 ELERQRQ---ENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309
E Q + E R Q + + LE +K E+ RQ +EE F+ GK
Sbjct: 1850 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1909
Query: 310 LKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL 369
+L E + ++ +++E+A +++ AE R ++ + +E
Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1969
Query: 370 TPGKLEINFEELLKQKMEEEKR---RTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG 426
K + E LK K+EE +R R E+E +L++ ++ Q+ + EE+ F
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA----QEAAQKRLQAEEKAHAFA 2025
Query: 427 LSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREA 486
+ ++ +EL + + L+ + E + +E E E AR +A EREA
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------EAEEARVQA------EREA 2072
Query: 487 ENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE-EQKLLRMQFEQR 545
+ + R + +E + +A E++ K E+E RR + EQ LR +++
Sbjct: 2073 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQ 2129
Query: 546 EIDAALQKKREEEEE 560
DA ++K ++ E+
Sbjct: 2130 AADAEMEKHKKFAEQ 2144
Score = 88.2 bits (217), Expect = 2e-17
Identities = 118/561 (21%), Positives = 246/561 (43%), Gaps = 59/561 (10%)
Query: 43 EERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVE-KAYVPKLTGT 101
E RR+ +E + + Q RE +RR+ E E L EE ++ + +A KL
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109
Query: 102 VKGRFA-----EMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNT 156
+ A E RQ++ E+ K+ EQ + +K ++++EL Q+E+
Sbjct: 2110 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2165
Query: 157 GTESASEEGDDSLL-ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQ 215
T+ D+ L + ++ + ++++ + + EE ++K RI E +
Sbjct: 2166 -TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK----ARIEAENR 2220
Query: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA--RKR 273
L++ + +E E + K+ + +L + +E R RQ + A++ A K
Sbjct: 2221 ALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279
Query: 274 LEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEA 333
L+E+ +A +EA R + Q K +E R+ +ED+++ A++ A
Sbjct: 2280 LKEKMQAVQEATRLKAEAELLQQQ-------------KELAQEQARRLQEDKEQMAQQLA 2326
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--EEKR 391
++ AE +R + + ++ + +++ + E + + KQ E E+
Sbjct: 2327 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2386
Query: 392 RTEEERKHK------LEMEKQEF----EQLRQEMGEEEEENETFGLSREYEEL-IKLKRS 440
RTE + K LE+++Q+ E+LR+ + E E E E L +E + L +K +
Sbjct: 2387 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--LQQEAKLLQLKSEEM 2444
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPA 500
++Q + L + + + Q E ++ ER +E ++ + E +++ +
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERF------IEQEKAKLEQLFQDEVAKAQQL 2498
Query: 501 RKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE- 559
R+ + + M+ +++ + EE +R+ E ++ +R +Q E+ Q++R++EE
Sbjct: 2499 REEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--KQEELQQLEQQRRQQEEL 2554
Query: 560 -EEEGSIMNGSTAEDEEQTRS 579
EE + EEQ R+
Sbjct: 2555 LAEENQRLREQLQLLEEQHRA 2575
Score = 66.6 bits (161), Expect = 7e-11
Identities = 124/631 (19%), Positives = 245/631 (38%), Gaps = 108/631 (17%)
Query: 3 DISQKAEILLSSSKPVPKTYVPKLG--KGDVKDKFEAMQRAREE-----RNQRRSRDE-- 53
++ + E L ++ VP T +P+L K +K K A A++ R++ R E
Sbjct: 1071 EVLRAHEEQLKEAQAVPAT-LPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVG 1128
Query: 54 ---KQRRKEQYIREREWNRRKQEIKE----MLASDD--EEDVSSKVEKAYVPKLTGTVKG 104
+QR E+ + W R ++ E +LA D + ++ + + + G
Sbjct: 1129 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1188
Query: 105 RFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEE 164
+ + ++RQE+ + + + + + + +++ + E+ + E++E+ + +
Sbjct: 1189 AWLQDARRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1247
Query: 165 GDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKC 224
D L + + + KK E +E + D R Y E
Sbjct: 1248 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV----DLRTHYSELT-------- 1295
Query: 225 LSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR-KKQAEEEARKRLEEEKRAFEE 283
+L+ +K E L R +E R +Q E R+RL E + A E+
Sbjct: 1296 ----------------TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1339
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA 343
R+ + + + K + E E Q+R E+ EEA +++K++
Sbjct: 1340 QRQ--------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1385
Query: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEEL----LKQKMEEEKRRTEEERKH 399
E + + ++ K E +L I EE+ L+ + E +R E
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQ 1444
Query: 400 KLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSI--------QAKNLKSK 451
L +E E +++ EE E L R+ ++ + KR + +A+ + K
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAER-----LRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1499
Query: 452 FEKIGQLSEKEIQ--------KKIEEERARRRAIDLEIKEREAE--------NFHEED-- 493
+ L E +Q ++ E ERAR+ + LE +R AE +F E+
Sbjct: 1500 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1559
Query: 494 -DVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKL-------LRMQFEQR 545
+ ++ + A + +A+ + A+ EE +R +E +L LR+Q E+
Sbjct: 1560 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1619
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQ 576
+L + E+++EE + EEQ
Sbjct: 1620 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1650
Score = 57.0 bits (136), Expect = 6e-08
Identities = 98/486 (20%), Positives = 208/486 (42%), Gaps = 110/486 (22%)
Query: 33 DKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE----IKEMLASDDEEDVSS 88
++ E ++++ EE+ Q R++ + K + E+E RR Q +++ A+D E +
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139
Query: 89 KV------EKAYVPKLTGTVKGRFAEMEKQR----QEEQRKR---TEEERKR-------- 127
K +KA V + T++ + E + Q+ +E QR + TE R+R
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2199
Query: 128 --RIEQDMLEKRKIQRELAKRAEQIEDINNTG------TESASEEGDDSLLITVVPVKSY 179
R++ + L K K + E RA + D +NT E + +++ ++V ++
Sbjct: 2200 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2259
Query: 180 KTSGKMKKNF-------EDLEKER----EEKERIKYE-----EDKRIRYEEQRPSLKEAK 223
+ +++ E + KE+ +E R+K E + K + E+ R ++ +
Sbjct: 2260 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2319
Query: 224 CLSLVMDDE-------IESEAKKE---SLSPGKLKLTFEELERQRQ------ENRKKQAE 267
++ + +E +E+E +++ S +LKL E+ R + + +KQAE
Sbjct: 2320 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2379
Query: 268 EEA-----------------------RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKG 304
E R++ + + EA ++ E E+ Q AK+
Sbjct: 2380 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--- 2436
Query: 305 YRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTI 364
L+L EEM+ ++E ++ + + + E+ +R ++ + ++ +
Sbjct: 2437 -----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL---QRERFIEQEKAKLEQLF 2488
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRT----EEERKHKLEMEK------QEFEQLRQE 414
E +L ++ +Q+ME+E++R EE R+ + E E+ +E +QL Q+
Sbjct: 2489 QDEVAKAQQLREE-QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2547
Query: 415 MGEEEE 420
++EE
Sbjct: 2548 RRQQEE 2553
Score = 53.5 bits (127), Expect = 6e-07
Identities = 87/407 (21%), Positives = 178/407 (43%), Gaps = 59/407 (14%)
Query: 31 VKDKFEAMQRA---REERNQRRSRDEKQRRKEQYIRER-EWNRRKQEIKEM--LASDDEE 84
+K + EA RA R++ N +R E+ + +Q E + QE + LA +D
Sbjct: 2211 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2270
Query: 85 DVSSKVEKAYVPKLTGT-------VKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR 137
+ EK K+ + + +K+ +EQ +R +E++++ +Q E +
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 138 KIQREL-AKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKER 196
QR L A+R Q+E SA E + ++ + S + ED ++ R
Sbjct: 2331 GFQRTLEAERQRQLE-------MSAEAER--------LKLRVAEMSRAQARAEEDAQRFR 2375
Query: 197 EEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELER 256
++ E I + R L + ++LV EI+ + +L+ ELER
Sbjct: 2376 KQAEEIGEKL--------HRTELATQEKVTLVQTLEIQRQQSDHDAE--RLREAIAELER 2425
Query: 257 QRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEE 316
+++ K Q E + + EE Q V +++ Q+T + + + K L
Sbjct: 2426 EKE---KLQQEAKLLQLKSEEM--------QTVQQEQLLQETQALQQSFLSEKDSL---- 2470
Query: 317 MERQRR-EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE 375
++R+R E EK K E+ + + + ++ E +R + + +E + +
Sbjct: 2471 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQ 2527
Query: 376 INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEEN 422
EE +++K +EE ++ E++R+ + E+ +E ++LR+++ EE++
Sbjct: 2528 HEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2573
Score = 33.9 bits (76), Expect = 0.50
Identities = 64/281 (22%), Positives = 112/281 (39%), Gaps = 67/281 (23%)
Query: 318 ERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE-- 375
E +R E++KA+ E + + AEA + + + + SP S+ LT GKLE
Sbjct: 986 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1045
Query: 376 -----INFEELL--------KQKMEEEKRRTEEERKH---------KLEMEKQEFEQLRQ 413
I E+L Q EE R EE+ K +LE K ++LR
Sbjct: 1046 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR- 1104
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERAR 473
+ E + TF R+ L+ E +L ++ ++ +E ER R
Sbjct: 1105 --AQAEAQQPTFDALRD----------------ELRGAQEVGERLQQRHGERDVEVERWR 1146
Query: 474 RRAIDL-----------EIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
R L ++++RE E + +R R+S P + A + +
Sbjct: 1147 ERVAQLLERWQAVLAQTDVRQRELEQLGRQ----LRYYRESADP------LGAWLQDARR 1196
Query: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQK-KREEEEEEE 562
+E+ + + + + +R Q Q + A L++ +R E+ EE
Sbjct: 1197 RQEQIQAMPLADSQAVREQLRQEQ--ALLEEIERHGEKVEE 1235
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 103 bits (257), Expect = 5e-22
Identities = 138/617 (22%), Positives = 263/617 (42%), Gaps = 85/617 (13%)
Query: 25 KLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEE 84
+L + + K +A + A+E Q+R ++E RR+E + ++ R QE + L E
Sbjct: 1511 QLAEAHAQAKAQAEREAKEL--QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1568
Query: 85 DVSSKVEKAYVP---KLTGTVKGRFAEMEKQRQEEQRKRTEEER---KRRIEQDMLEKRK 138
++ +K +A +L + R ++ + E QR E E + R E+ +KR+
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628
Query: 139 IQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE 198
Q E + Q++D + ++ E + ++K + E RE+
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVE-----------------LASRVKA---EAEAAREK 1668
Query: 199 KERIKYEEDKRIRYEEQRPSLKEAKC-LSLVMDDEIESEAKKESLSPGKLKLTFEELERQ 257
+ ++ E+ R++ EE L++A+ + + +E+ + + +F E Q
Sbjct: 1669 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1728
Query: 258 RQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEM 317
+ + +++ A+ R E E+RA ++A + E+ E + K +L+L EE+
Sbjct: 1729 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1788
Query: 318 ERQR------REDEKRKAEEEARRRIEEEKKAF-------AEARRNMVVDDDSPEMYKTI 364
+Q+ E +K +AE EARRR + E++A E + + + + +
Sbjct: 1789 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1848
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRTEEE------RKHKLEME----KQEFEQLRQE 414
QE + + E E +Q +EEE R + E ++ +LE E + E E L
Sbjct: 1849 EQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1907
Query: 415 MGEEEEENET------------FGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKE 462
EEE+ + G RE E R+ + +AK + E+ E
Sbjct: 1908 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967
Query: 463 IQKKIEEERAR-------RRAIDLEIKEREAENFHEE---DDVDVRPARKSEAPFTHKVN 512
++ + E+ A + ++ +KE+EAEN +D + R E HK +
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027
Query: 513 MKARFEQMAKAREEEEQRR---IEEQKLLRMQFEQR--EIDAALQKK---REEEEEEEGS 564
++ R Q+ KA + E +R+ +E+ R Q E+ + A+ +K + E E E G
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087
Query: 565 IMNGSTAEDEEQTRSGA 581
I S AED +++ A
Sbjct: 2088 IR--SNAEDTLRSKEQA 2102
Score = 95.1 bits (235), Expect = 2e-19
Identities = 139/615 (22%), Positives = 256/615 (41%), Gaps = 99/615 (16%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKL 98
+ A ER +R + DE +R+ E + + K +I+E LA K + + +
Sbjct: 1996 KEAENERLRRLAEDEAFQRRRL---EEQAAQHKADIEERLAQ------LRKASDSELERQ 2046
Query: 99 TGTVKGRFAEMEKQRQEEQRKRTEEE---RKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
G V+ QR++ EEE K E+ K +++ EL + ED
Sbjct: 2047 KGLVEDTL---------RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF---EDLEKER----EEKERIK--YEE 206
+ ++ E L + + +++K+ E+ ++R EE ER+K EE
Sbjct: 2098 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2157
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
+R+R ++ S ++ + +++E K + + + +E E Q+ +++
Sbjct: 2158 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQELQQTLQQEQSV 2212
Query: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE- 325
++ R E +RA EEA V + E + + + +LK S EE + R + +
Sbjct: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQA 2270
Query: 326 -----KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEE 380
+++AE+EA RR + E+ A R D E +K + E+
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFA-------------EQ 2313
Query: 381 LLKQKMEEEKRRTE-----EERKHKLEMEKQEFEQLRQEMGE-----EEEENETFGLSRE 430
L+QK + E+ T EE H+ + +E ++L+ E E + E E F + +
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 431 YEELIKLKRSGSIQAKN--------------LKSKFEKIGQLSEKEIQKKI-EEERARRR 475
EEL KLK I+A+N L+ + EK+ Q++E+ + + +E AR R
Sbjct: 2374 MEELSKLK--ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431
Query: 476 AI---DLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRI 532
+ DL + AE +E V+ A + +A K ++ A+ R +E++ ++
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR-RLQEDKEQM 2490
Query: 533 EEQKLLRMQFEQREIDAALQKKREEEEEEEG--------SIMNGSTAEDEEQTRSGAPWF 584
+Q Q QR ++A Q++ E E E S ED ++ R A
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2550
Query: 585 KKPLKNTSVVDSEPV 599
+ L T + E V
Sbjct: 2551 GEKLHRTELATQEKV 2565
Score = 88.2 bits (217), Expect = 2e-17
Identities = 120/555 (21%), Positives = 241/555 (43%), Gaps = 63/555 (11%)
Query: 36 EAMQRAREERNQRRSRDEKQRR---KEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
+++ +A E+ + + E +RR +EQ +R+RE ++ E + LA + + E+
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-AEQ 1850
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE------RKRRIEQDMLEKR-KIQRELAK 145
+ T +G E ++Q EE+ R + E +++ +E ++ + R +++ LA
Sbjct: 1851 ELIRLRAETEQG---EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1907
Query: 146 RAEQIEDINNTGTESASEEGDDS-----LLITVVPVKSYKTSGKMKKNF--EDLEKEREE 198
+A E+ +T +S ++ L +++ K ++ ED ++R E
Sbjct: 1908 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967
Query: 199 KERIKYE------EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFE 252
ER+ E E R++ E + +LKE + ++ + A+ E+ +L E
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEI-ALKEKEA----ENERLRRLAEDEAFQRRRL----E 2018
Query: 253 ELERQRQ---ENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309
E Q + E R Q + + LE +K E+ RQ +EE F+ GK
Sbjct: 2019 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 2078
Query: 310 LKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL 369
+L E + ++ +++E+A +++ AE R ++ + +E
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138
Query: 370 TPGKLEINFEELLKQKMEEEKR---RTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG 426
K + E LK K+EE +R R E+E +L++ ++ Q+ + EE+ F
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA----QEAAQKRLQAEEKAHAFA 2194
Query: 427 LSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREA 486
+ ++ +EL + + L+ + E + +E E E AR +A EREA
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------EAEEARVQA------EREA 2241
Query: 487 ENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE-EQKLLRMQFEQR 545
+ + R + +E + +A E++ K E+E RR + EQ LR +++
Sbjct: 2242 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQ 2298
Query: 546 EIDAALQKKREEEEE 560
DA ++K ++ E+
Sbjct: 2299 AADAEMEKHKKFAEQ 2313
Score = 88.2 bits (217), Expect = 2e-17
Identities = 118/561 (21%), Positives = 246/561 (43%), Gaps = 59/561 (10%)
Query: 43 EERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVE-KAYVPKLTGT 101
E RR+ +E + + Q RE +RR+ E E L EE ++ + +A KL
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278
Query: 102 VKGRFA-----EMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNT 156
+ A E RQ++ E+ K+ EQ + +K ++++EL Q+E+
Sbjct: 2279 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2334
Query: 157 GTESASEEGDDSLL-ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQ 215
T+ D+ L + ++ + ++++ + + EE ++K RI E +
Sbjct: 2335 -TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK----ARIEAENR 2389
Query: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA--RKR 273
L++ + +E E + K+ + +L + +E R RQ + A++ A K
Sbjct: 2390 ALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448
Query: 274 LEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEA 333
L+E+ +A +EA R + Q K +E R+ +ED+++ A++ A
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQQQ-------------KELAQEQARRLQEDKEQMAQQLA 2495
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--EEKR 391
++ AE +R + + ++ + +++ + E + + KQ E E+
Sbjct: 2496 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2555
Query: 392 RTEEERKHK------LEMEKQEF----EQLRQEMGEEEEENETFGLSREYEEL-IKLKRS 440
RTE + K LE+++Q+ E+LR+ + E E E E L +E + L +K +
Sbjct: 2556 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--LQQEAKLLQLKSEEM 2613
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPA 500
++Q + L + + + Q E ++ ER +E ++ + E +++ +
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERF------IEQEKAKLEQLFQDEVAKAQQL 2667
Query: 501 RKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE- 559
R+ + + M+ +++ + EE +R+ E ++ +R +Q E+ Q++R++EE
Sbjct: 2668 REEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--KQEELQQLEQQRRQQEEL 2723
Query: 560 -EEEGSIMNGSTAEDEEQTRS 579
EE + EEQ R+
Sbjct: 2724 LAEENQRLREQLQLLEEQHRA 2744
Score = 66.6 bits (161), Expect = 7e-11
Identities = 124/631 (19%), Positives = 245/631 (38%), Gaps = 108/631 (17%)
Query: 3 DISQKAEILLSSSKPVPKTYVPKLG--KGDVKDKFEAMQRAREE-----RNQRRSRDE-- 53
++ + E L ++ VP T +P+L K +K K A A++ R++ R E
Sbjct: 1240 EVLRAHEEQLKEAQAVPAT-LPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVG 1297
Query: 54 ---KQRRKEQYIREREWNRRKQEIKE----MLASDD--EEDVSSKVEKAYVPKLTGTVKG 104
+QR E+ + W R ++ E +LA D + ++ + + + G
Sbjct: 1298 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1357
Query: 105 RFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEE 164
+ + ++RQE+ + + + + + + +++ + E+ + E++E+ + +
Sbjct: 1358 AWLQDARRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1416
Query: 165 GDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKC 224
D L + + + KK E +E + D R Y E
Sbjct: 1417 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV----DLRTHYSELT-------- 1464
Query: 225 LSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR-KKQAEEEARKRLEEEKRAFEE 283
+L+ +K E L R +E R +Q E R+RL E + A E+
Sbjct: 1465 ----------------TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1508
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA 343
R+ + + + K + E E Q+R E+ EEA +++K++
Sbjct: 1509 QRQ--------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554
Query: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEEL----LKQKMEEEKRRTEEERKH 399
E + + ++ K E +L I EE+ L+ + E +R E
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQ 1613
Query: 400 KLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSI--------QAKNLKSK 451
L +E E +++ EE E L R+ ++ + KR + +A+ + K
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAER-----LRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1668
Query: 452 FEKIGQLSEKEIQ--------KKIEEERARRRAIDLEIKEREAE--------NFHEED-- 493
+ L E +Q ++ E ERAR+ + LE +R AE +F E+
Sbjct: 1669 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1728
Query: 494 -DVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKL-------LRMQFEQR 545
+ ++ + A + +A+ + A+ EE +R +E +L LR+Q E+
Sbjct: 1729 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1788
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQ 576
+L + E+++EE + EEQ
Sbjct: 1789 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1819
Score = 57.0 bits (136), Expect = 6e-08
Identities = 98/486 (20%), Positives = 208/486 (42%), Gaps = 110/486 (22%)
Query: 33 DKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE----IKEMLASDDEEDVSS 88
++ E ++++ EE+ Q R++ + K + E+E RR Q +++ A+D E +
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308
Query: 89 KV------EKAYVPKLTGTVKGRFAEMEKQR----QEEQRKR---TEEERKR-------- 127
K +KA V + T++ + E + Q+ +E QR + TE R+R
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2368
Query: 128 --RIEQDMLEKRKIQRELAKRAEQIEDINNTG------TESASEEGDDSLLITVVPVKSY 179
R++ + L K K + E RA + D +NT E + +++ ++V ++
Sbjct: 2369 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2428
Query: 180 KTSGKMKKNF-------EDLEKER----EEKERIKYE-----EDKRIRYEEQRPSLKEAK 223
+ +++ E + KE+ +E R+K E + K + E+ R ++ +
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2488
Query: 224 CLSLVMDDE-------IESEAKKE---SLSPGKLKLTFEELERQRQ------ENRKKQAE 267
++ + +E +E+E +++ S +LKL E+ R + + +KQAE
Sbjct: 2489 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2548
Query: 268 EEA-----------------------RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKG 304
E R++ + + EA ++ E E+ Q AK+
Sbjct: 2549 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--- 2605
Query: 305 YRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTI 364
L+L EEM+ ++E ++ + + + E+ +R ++ + ++ +
Sbjct: 2606 -----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL---QRERFIEQEKAKLEQLF 2657
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRT----EEERKHKLEMEK------QEFEQLRQE 414
E +L ++ +Q+ME+E++R EE R+ + E E+ +E +QL Q+
Sbjct: 2658 QDEVAKAQQLREE-QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2716
Query: 415 MGEEEE 420
++EE
Sbjct: 2717 RRQQEE 2722
Score = 53.5 bits (127), Expect = 6e-07
Identities = 87/407 (21%), Positives = 178/407 (43%), Gaps = 59/407 (14%)
Query: 31 VKDKFEAMQRA---REERNQRRSRDEKQRRKEQYIRER-EWNRRKQEIKEM--LASDDEE 84
+K + EA RA R++ N +R E+ + +Q E + QE + LA +D
Sbjct: 2380 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2439
Query: 85 DVSSKVEKAYVPKLTGT-------VKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR 137
+ EK K+ + + +K+ +EQ +R +E++++ +Q E +
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 138 KIQREL-AKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKER 196
QR L A+R Q+E SA E + ++ + S + ED ++ R
Sbjct: 2500 GFQRTLEAERQRQLE-------MSAEAER--------LKLRVAEMSRAQARAEEDAQRFR 2544
Query: 197 EEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELER 256
++ E I + R L + ++LV EI+ + +L+ ELER
Sbjct: 2545 KQAEEIGEKL--------HRTELATQEKVTLVQTLEIQRQQSDHDAE--RLREAIAELER 2594
Query: 257 QRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEE 316
+++ K Q E + + EE Q V +++ Q+T + + + K L
Sbjct: 2595 EKE---KLQQEAKLLQLKSEEM--------QTVQQEQLLQETQALQQSFLSEKDSL---- 2639
Query: 317 MERQRR-EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE 375
++R+R E EK K E+ + + + ++ E +R + + +E + +
Sbjct: 2640 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQ 2696
Query: 376 INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEEN 422
EE +++K +EE ++ E++R+ + E+ +E ++LR+++ EE++
Sbjct: 2697 HEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742
Score = 33.9 bits (76), Expect = 0.50
Identities = 64/281 (22%), Positives = 112/281 (39%), Gaps = 67/281 (23%)
Query: 318 ERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE-- 375
E +R E++KA+ E + + AEA + + + + SP S+ LT GKLE
Sbjct: 1155 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1214
Query: 376 -----INFEELL--------KQKMEEEKRRTEEERKH---------KLEMEKQEFEQLRQ 413
I E+L Q EE R EE+ K +LE K ++LR
Sbjct: 1215 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR- 1273
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERAR 473
+ E + TF R+ L+ E +L ++ ++ +E ER R
Sbjct: 1274 --AQAEAQQPTFDALRD----------------ELRGAQEVGERLQQRHGERDVEVERWR 1315
Query: 474 RRAIDL-----------EIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
R L ++++RE E + +R R+S P + A + +
Sbjct: 1316 ERVAQLLERWQAVLAQTDVRQRELEQLGRQ----LRYYRESADP------LGAWLQDARR 1365
Query: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQK-KREEEEEEE 562
+E+ + + + + +R Q Q + A L++ +R E+ EE
Sbjct: 1366 RQEQIQAMPLADSQAVREQLRQEQ--ALLEEIERHGEKVEE 1404
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 103 bits (257), Expect = 5e-22
Identities = 138/617 (22%), Positives = 263/617 (42%), Gaps = 85/617 (13%)
Query: 25 KLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEE 84
+L + + K +A + A+E Q+R ++E RR+E + ++ R QE + L E
Sbjct: 1352 QLAEAHAQAKAQAEREAKEL--QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1409
Query: 85 DVSSKVEKAYVP---KLTGTVKGRFAEMEKQRQEEQRKRTEEER---KRRIEQDMLEKRK 138
++ +K +A +L + R ++ + E QR E E + R E+ +KR+
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
Query: 139 IQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE 198
Q E + Q++D + ++ E + ++K + E RE+
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVE-----------------LASRVKA---EAEAAREK 1509
Query: 199 KERIKYEEDKRIRYEEQRPSLKEAKC-LSLVMDDEIESEAKKESLSPGKLKLTFEELERQ 257
+ ++ E+ R++ EE L++A+ + + +E+ + + +F E Q
Sbjct: 1510 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1569
Query: 258 RQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEM 317
+ + +++ A+ R E E+RA ++A + E+ E + K +L+L EE+
Sbjct: 1570 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1629
Query: 318 ERQR------REDEKRKAEEEARRRIEEEKKAF-------AEARRNMVVDDDSPEMYKTI 364
+Q+ E +K +AE EARRR + E++A E + + + + +
Sbjct: 1630 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1689
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRTEEE------RKHKLEME----KQEFEQLRQE 414
QE + + E E +Q +EEE R + E ++ +LE E + E E L
Sbjct: 1690 EQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1748
Query: 415 MGEEEEENET------------FGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKE 462
EEE+ + G RE E R+ + +AK + E+ E
Sbjct: 1749 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808
Query: 463 IQKKIEEERAR-------RRAIDLEIKEREAENFHEE---DDVDVRPARKSEAPFTHKVN 512
++ + E+ A + ++ +KE+EAEN +D + R E HK +
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1868
Query: 513 MKARFEQMAKAREEEEQRR---IEEQKLLRMQFEQR--EIDAALQKK---REEEEEEEGS 564
++ R Q+ KA + E +R+ +E+ R Q E+ + A+ +K + E E E G
Sbjct: 1869 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928
Query: 565 IMNGSTAEDEEQTRSGA 581
I S AED +++ A
Sbjct: 1929 IR--SNAEDTLRSKEQA 1943
Score = 95.1 bits (235), Expect = 2e-19
Identities = 139/615 (22%), Positives = 256/615 (41%), Gaps = 99/615 (16%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKL 98
+ A ER +R + DE +R+ E + + K +I+E LA K + + +
Sbjct: 1837 KEAENERLRRLAEDEAFQRRRL---EEQAAQHKADIEERLAQ------LRKASDSELERQ 1887
Query: 99 TGTVKGRFAEMEKQRQEEQRKRTEEE---RKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
G V+ QR++ EEE K E+ K +++ EL + ED
Sbjct: 1888 KGLVEDTL---------RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF---EDLEKER----EEKERIK--YEE 206
+ ++ E L + + +++K+ E+ ++R EE ER+K EE
Sbjct: 1939 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1998
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
+R+R ++ S ++ + +++E K + + + +E E Q+ +++
Sbjct: 1999 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQELQQTLQQEQSV 2053
Query: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE- 325
++ R E +RA EEA V + E + + + +LK S EE + R + +
Sbjct: 2054 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQA 2111
Query: 326 -----KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEE 380
+++AE+EA RR + E+ A R D E +K + E+
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFA-------------EQ 2154
Query: 381 LLKQKMEEEKRRTE-----EERKHKLEMEKQEFEQLRQEMGE-----EEEENETFGLSRE 430
L+QK + E+ T EE H+ + +E ++L+ E E + E E F + +
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 431 YEELIKLKRSGSIQAKN--------------LKSKFEKIGQLSEKEIQKKI-EEERARRR 475
EEL KLK I+A+N L+ + EK+ Q++E+ + + +E AR R
Sbjct: 2215 MEELSKLK--ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272
Query: 476 AI---DLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRI 532
+ DL + AE +E V+ A + +A K ++ A+ R +E++ ++
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR-RLQEDKEQM 2331
Query: 533 EEQKLLRMQFEQREIDAALQKKREEEEEEEG--------SIMNGSTAEDEEQTRSGAPWF 584
+Q Q QR ++A Q++ E E E S ED ++ R A
Sbjct: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2391
Query: 585 KKPLKNTSVVDSEPV 599
+ L T + E V
Sbjct: 2392 GEKLHRTELATQEKV 2406
Score = 88.2 bits (217), Expect = 2e-17
Identities = 120/555 (21%), Positives = 241/555 (43%), Gaps = 63/555 (11%)
Query: 36 EAMQRAREERNQRRSRDEKQRR---KEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
+++ +A E+ + + E +RR +EQ +R+RE ++ E + LA + + E+
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-AEQ 1691
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE------RKRRIEQDMLEKR-KIQRELAK 145
+ T +G E ++Q EE+ R + E +++ +E ++ + R +++ LA
Sbjct: 1692 ELIRLRAETEQG---EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1748
Query: 146 RAEQIEDINNTGTESASEEGDDS-----LLITVVPVKSYKTSGKMKKNF--EDLEKEREE 198
+A E+ +T +S ++ L +++ K ++ ED ++R E
Sbjct: 1749 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808
Query: 199 KERIKYE------EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFE 252
ER+ E E R++ E + +LKE + ++ + A+ E+ +L E
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEI-ALKEKEA----ENERLRRLAEDEAFQRRRL----E 1859
Query: 253 ELERQRQ---ENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309
E Q + E R Q + + LE +K E+ RQ +EE F+ GK
Sbjct: 1860 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1919
Query: 310 LKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL 369
+L E + ++ +++E+A +++ AE R ++ + +E
Sbjct: 1920 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979
Query: 370 TPGKLEINFEELLKQKMEEEKR---RTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG 426
K + E LK K+EE +R R E+E +L++ ++ Q+ + EE+ F
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA----QEAAQKRLQAEEKAHAFA 2035
Query: 427 LSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREA 486
+ ++ +EL + + L+ + E + +E E E AR +A EREA
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------EAEEARVQA------EREA 2082
Query: 487 ENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE-EQKLLRMQFEQR 545
+ + R + +E + +A E++ K E+E RR + EQ LR +++
Sbjct: 2083 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQ 2139
Query: 546 EIDAALQKKREEEEE 560
DA ++K ++ E+
Sbjct: 2140 AADAEMEKHKKFAEQ 2154
Score = 88.2 bits (217), Expect = 2e-17
Identities = 118/561 (21%), Positives = 246/561 (43%), Gaps = 59/561 (10%)
Query: 43 EERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVE-KAYVPKLTGT 101
E RR+ +E + + Q RE +RR+ E E L EE ++ + +A KL
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119
Query: 102 VKGRFA-----EMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNT 156
+ A E RQ++ E+ K+ EQ + +K ++++EL Q+E+
Sbjct: 2120 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2175
Query: 157 GTESASEEGDDSLL-ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQ 215
T+ D+ L + ++ + ++++ + + EE ++K RI E +
Sbjct: 2176 -TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK----ARIEAENR 2230
Query: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA--RKR 273
L++ + +E E + K+ + +L + +E R RQ + A++ A K
Sbjct: 2231 ALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289
Query: 274 LEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEA 333
L+E+ +A +EA R + Q K +E R+ +ED+++ A++ A
Sbjct: 2290 LKEKMQAVQEATRLKAEAELLQQQ-------------KELAQEQARRLQEDKEQMAQQLA 2336
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--EEKR 391
++ AE +R + + ++ + +++ + E + + KQ E E+
Sbjct: 2337 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2396
Query: 392 RTEEERKHK------LEMEKQEF----EQLRQEMGEEEEENETFGLSREYEEL-IKLKRS 440
RTE + K LE+++Q+ E+LR+ + E E E E L +E + L +K +
Sbjct: 2397 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--LQQEAKLLQLKSEEM 2454
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPA 500
++Q + L + + + Q E ++ ER +E ++ + E +++ +
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERF------IEQEKAKLEQLFQDEVAKAQQL 2508
Query: 501 RKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE- 559
R+ + + M+ +++ + EE +R+ E ++ +R +Q E+ Q++R++EE
Sbjct: 2509 REEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--KQEELQQLEQQRRQQEEL 2564
Query: 560 -EEEGSIMNGSTAEDEEQTRS 579
EE + EEQ R+
Sbjct: 2565 LAEENQRLREQLQLLEEQHRA 2585
Score = 66.6 bits (161), Expect = 7e-11
Identities = 124/631 (19%), Positives = 245/631 (38%), Gaps = 108/631 (17%)
Query: 3 DISQKAEILLSSSKPVPKTYVPKLG--KGDVKDKFEAMQRAREE-----RNQRRSRDE-- 53
++ + E L ++ VP T +P+L K +K K A A++ R++ R E
Sbjct: 1081 EVLRAHEEQLKEAQAVPAT-LPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVG 1138
Query: 54 ---KQRRKEQYIREREWNRRKQEIKE----MLASDD--EEDVSSKVEKAYVPKLTGTVKG 104
+QR E+ + W R ++ E +LA D + ++ + + + G
Sbjct: 1139 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1198
Query: 105 RFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEE 164
+ + ++RQE+ + + + + + + +++ + E+ + E++E+ + +
Sbjct: 1199 AWLQDARRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1257
Query: 165 GDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKC 224
D L + + + KK E +E + D R Y E
Sbjct: 1258 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV----DLRTHYSELT-------- 1305
Query: 225 LSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR-KKQAEEEARKRLEEEKRAFEE 283
+L+ +K E L R +E R +Q E R+RL E + A E+
Sbjct: 1306 ----------------TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1349
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA 343
R+ + + + K + E E Q+R E+ EEA +++K++
Sbjct: 1350 QRQ--------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1395
Query: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEEL----LKQKMEEEKRRTEEERKH 399
E + + ++ K E +L I EE+ L+ + E +R E
Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQ 1454
Query: 400 KLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSI--------QAKNLKSK 451
L +E E +++ EE E L R+ ++ + KR + +A+ + K
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAER-----LRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1509
Query: 452 FEKIGQLSEKEIQ--------KKIEEERARRRAIDLEIKEREAE--------NFHEED-- 493
+ L E +Q ++ E ERAR+ + LE +R AE +F E+
Sbjct: 1510 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1569
Query: 494 -DVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKL-------LRMQFEQR 545
+ ++ + A + +A+ + A+ EE +R +E +L LR+Q E+
Sbjct: 1570 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1629
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQ 576
+L + E+++EE + EEQ
Sbjct: 1630 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1660
Score = 57.0 bits (136), Expect = 6e-08
Identities = 98/486 (20%), Positives = 208/486 (42%), Gaps = 110/486 (22%)
Query: 33 DKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE----IKEMLASDDEEDVSS 88
++ E ++++ EE+ Q R++ + K + E+E RR Q +++ A+D E +
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149
Query: 89 KV------EKAYVPKLTGTVKGRFAEMEKQR----QEEQRKR---TEEERKR-------- 127
K +KA V + T++ + E + Q+ +E QR + TE R+R
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2209
Query: 128 --RIEQDMLEKRKIQRELAKRAEQIEDINNTG------TESASEEGDDSLLITVVPVKSY 179
R++ + L K K + E RA + D +NT E + +++ ++V ++
Sbjct: 2210 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2269
Query: 180 KTSGKMKKNF-------EDLEKER----EEKERIKYE-----EDKRIRYEEQRPSLKEAK 223
+ +++ E + KE+ +E R+K E + K + E+ R ++ +
Sbjct: 2270 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2329
Query: 224 CLSLVMDDE-------IESEAKKE---SLSPGKLKLTFEELERQRQ------ENRKKQAE 267
++ + +E +E+E +++ S +LKL E+ R + + +KQAE
Sbjct: 2330 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2389
Query: 268 EEA-----------------------RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKG 304
E R++ + + EA ++ E E+ Q AK+
Sbjct: 2390 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--- 2446
Query: 305 YRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTI 364
L+L EEM+ ++E ++ + + + E+ +R ++ + ++ +
Sbjct: 2447 -----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL---QRERFIEQEKAKLEQLF 2498
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRT----EEERKHKLEMEK------QEFEQLRQE 414
E +L ++ +Q+ME+E++R EE R+ + E E+ +E +QL Q+
Sbjct: 2499 QDEVAKAQQLREE-QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2557
Query: 415 MGEEEE 420
++EE
Sbjct: 2558 RRQQEE 2563
Score = 53.5 bits (127), Expect = 6e-07
Identities = 87/407 (21%), Positives = 178/407 (43%), Gaps = 59/407 (14%)
Query: 31 VKDKFEAMQRA---REERNQRRSRDEKQRRKEQYIRER-EWNRRKQEIKEM--LASDDEE 84
+K + EA RA R++ N +R E+ + +Q E + QE + LA +D
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280
Query: 85 DVSSKVEKAYVPKLTGT-------VKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR 137
+ EK K+ + + +K+ +EQ +R +E++++ +Q E +
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 138 KIQREL-AKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKER 196
QR L A+R Q+E SA E + ++ + S + ED ++ R
Sbjct: 2341 GFQRTLEAERQRQLE-------MSAEAER--------LKLRVAEMSRAQARAEEDAQRFR 2385
Query: 197 EEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELER 256
++ E I + R L + ++LV EI+ + +L+ ELER
Sbjct: 2386 KQAEEIGEKL--------HRTELATQEKVTLVQTLEIQRQQSDHDAE--RLREAIAELER 2435
Query: 257 QRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEE 316
+++ K Q E + + EE Q V +++ Q+T + + + K L
Sbjct: 2436 EKE---KLQQEAKLLQLKSEEM--------QTVQQEQLLQETQALQQSFLSEKDSL---- 2480
Query: 317 MERQRR-EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE 375
++R+R E EK K E+ + + + ++ E +R + + +E + +
Sbjct: 2481 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQ 2537
Query: 376 INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEEN 422
EE +++K +EE ++ E++R+ + E+ +E ++LR+++ EE++
Sbjct: 2538 HEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583
Score = 33.9 bits (76), Expect = 0.50
Identities = 64/281 (22%), Positives = 112/281 (39%), Gaps = 67/281 (23%)
Query: 318 ERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE-- 375
E +R E++KA+ E + + AEA + + + + SP S+ LT GKLE
Sbjct: 996 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1055
Query: 376 -----INFEELL--------KQKMEEEKRRTEEERKH---------KLEMEKQEFEQLRQ 413
I E+L Q EE R EE+ K +LE K ++LR
Sbjct: 1056 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR- 1114
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERAR 473
+ E + TF R+ L+ E +L ++ ++ +E ER R
Sbjct: 1115 --AQAEAQQPTFDALRD----------------ELRGAQEVGERLQQRHGERDVEVERWR 1156
Query: 474 RRAIDL-----------EIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
R L ++++RE E + +R R+S P + A + +
Sbjct: 1157 ERVAQLLERWQAVLAQTDVRQRELEQLGRQ----LRYYRESADP------LGAWLQDARR 1206
Query: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQK-KREEEEEEE 562
+E+ + + + + +R Q Q + A L++ +R E+ EE
Sbjct: 1207 RQEQIQAMPLADSQAVREQLRQEQ--ALLEEIERHGEKVEE 1245
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 103 bits (257), Expect = 5e-22
Identities = 138/617 (22%), Positives = 263/617 (42%), Gaps = 85/617 (13%)
Query: 25 KLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEE 84
+L + + K +A + A+E Q+R ++E RR+E + ++ R QE + L E
Sbjct: 1360 QLAEAHAQAKAQAEREAKEL--QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1417
Query: 85 DVSSKVEKAYVP---KLTGTVKGRFAEMEKQRQEEQRKRTEEER---KRRIEQDMLEKRK 138
++ +K +A +L + R ++ + E QR E E + R E+ +KR+
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477
Query: 139 IQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE 198
Q E + Q++D + ++ E + ++K + E RE+
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVE-----------------LASRVKA---EAEAAREK 1517
Query: 199 KERIKYEEDKRIRYEEQRPSLKEAKC-LSLVMDDEIESEAKKESLSPGKLKLTFEELERQ 257
+ ++ E+ R++ EE L++A+ + + +E+ + + +F E Q
Sbjct: 1518 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1577
Query: 258 RQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEM 317
+ + +++ A+ R E E+RA ++A + E+ E + K +L+L EE+
Sbjct: 1578 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1637
Query: 318 ERQR------REDEKRKAEEEARRRIEEEKKAF-------AEARRNMVVDDDSPEMYKTI 364
+Q+ E +K +AE EARRR + E++A E + + + + +
Sbjct: 1638 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1697
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRTEEE------RKHKLEME----KQEFEQLRQE 414
QE + + E E +Q +EEE R + E ++ +LE E + E E L
Sbjct: 1698 EQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1756
Query: 415 MGEEEEENET------------FGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKE 462
EEE+ + G RE E R+ + +AK + E+ E
Sbjct: 1757 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1816
Query: 463 IQKKIEEERAR-------RRAIDLEIKEREAENFHEE---DDVDVRPARKSEAPFTHKVN 512
++ + E+ A + ++ +KE+EAEN +D + R E HK +
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1876
Query: 513 MKARFEQMAKAREEEEQRR---IEEQKLLRMQFEQR--EIDAALQKK---REEEEEEEGS 564
++ R Q+ KA + E +R+ +E+ R Q E+ + A+ +K + E E E G
Sbjct: 1877 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936
Query: 565 IMNGSTAEDEEQTRSGA 581
I S AED +++ A
Sbjct: 1937 IR--SNAEDTLRSKEQA 1951
Score = 95.1 bits (235), Expect = 2e-19
Identities = 139/615 (22%), Positives = 256/615 (41%), Gaps = 99/615 (16%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKL 98
+ A ER +R + DE +R+ E + + K +I+E LA K + + +
Sbjct: 1845 KEAENERLRRLAEDEAFQRRRL---EEQAAQHKADIEERLAQ------LRKASDSELERQ 1895
Query: 99 TGTVKGRFAEMEKQRQEEQRKRTEEE---RKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
G V+ QR++ EEE K E+ K +++ EL + ED
Sbjct: 1896 KGLVEDTL---------RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1946
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF---EDLEKER----EEKERIK--YEE 206
+ ++ E L + + +++K+ E+ ++R EE ER+K EE
Sbjct: 1947 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2006
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
+R+R ++ S ++ + +++E K + + + +E E Q+ +++
Sbjct: 2007 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQELQQTLQQEQSV 2061
Query: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE- 325
++ R E +RA EEA V + E + + + +LK S EE + R + +
Sbjct: 2062 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQA 2119
Query: 326 -----KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEE 380
+++AE+EA RR + E+ A R D E +K + E+
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFA-------------EQ 2162
Query: 381 LLKQKMEEEKRRTE-----EERKHKLEMEKQEFEQLRQEMGE-----EEEENETFGLSRE 430
L+QK + E+ T EE H+ + +E ++L+ E E + E E F + +
Sbjct: 2163 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 431 YEELIKLKRSGSIQAKN--------------LKSKFEKIGQLSEKEIQKKI-EEERARRR 475
EEL KLK I+A+N L+ + EK+ Q++E+ + + +E AR R
Sbjct: 2223 MEELSKLK--ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280
Query: 476 AI---DLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRI 532
+ DL + AE +E V+ A + +A K ++ A+ R +E++ ++
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR-RLQEDKEQM 2339
Query: 533 EEQKLLRMQFEQREIDAALQKKREEEEEEEG--------SIMNGSTAEDEEQTRSGAPWF 584
+Q Q QR ++A Q++ E E E S ED ++ R A
Sbjct: 2340 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2399
Query: 585 KKPLKNTSVVDSEPV 599
+ L T + E V
Sbjct: 2400 GEKLHRTELATQEKV 2414
Score = 88.2 bits (217), Expect = 2e-17
Identities = 120/555 (21%), Positives = 241/555 (43%), Gaps = 63/555 (11%)
Query: 36 EAMQRAREERNQRRSRDEKQRR---KEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
+++ +A E+ + + E +RR +EQ +R+RE ++ E + LA + + E+
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-AEQ 1699
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE------RKRRIEQDMLEKR-KIQRELAK 145
+ T +G E ++Q EE+ R + E +++ +E ++ + R +++ LA
Sbjct: 1700 ELIRLRAETEQG---EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1756
Query: 146 RAEQIEDINNTGTESASEEGDDS-----LLITVVPVKSYKTSGKMKKNF--EDLEKEREE 198
+A E+ +T +S ++ L +++ K ++ ED ++R E
Sbjct: 1757 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1816
Query: 199 KERIKYE------EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFE 252
ER+ E E R++ E + +LKE + ++ + A+ E+ +L E
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEI-ALKEKEA----ENERLRRLAEDEAFQRRRL----E 1867
Query: 253 ELERQRQ---ENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309
E Q + E R Q + + LE +K E+ RQ +EE F+ GK
Sbjct: 1868 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1927
Query: 310 LKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL 369
+L E + ++ +++E+A +++ AE R ++ + +E
Sbjct: 1928 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1987
Query: 370 TPGKLEINFEELLKQKMEEEKR---RTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG 426
K + E LK K+EE +R R E+E +L++ ++ Q+ + EE+ F
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA----QEAAQKRLQAEEKAHAFA 2043
Query: 427 LSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREA 486
+ ++ +EL + + L+ + E + +E E E AR +A EREA
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------EAEEARVQA------EREA 2090
Query: 487 ENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE-EQKLLRMQFEQR 545
+ + R + +E + +A E++ K E+E RR + EQ LR +++
Sbjct: 2091 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQ 2147
Query: 546 EIDAALQKKREEEEE 560
DA ++K ++ E+
Sbjct: 2148 AADAEMEKHKKFAEQ 2162
Score = 88.2 bits (217), Expect = 2e-17
Identities = 118/561 (21%), Positives = 246/561 (43%), Gaps = 59/561 (10%)
Query: 43 EERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVE-KAYVPKLTGT 101
E RR+ +E + + Q RE +RR+ E E L EE ++ + +A KL
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127
Query: 102 VKGRFA-----EMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNT 156
+ A E RQ++ E+ K+ EQ + +K ++++EL Q+E+
Sbjct: 2128 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2183
Query: 157 GTESASEEGDDSLL-ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQ 215
T+ D+ L + ++ + ++++ + + EE ++K RI E +
Sbjct: 2184 -TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK----ARIEAENR 2238
Query: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA--RKR 273
L++ + +E E + K+ + +L + +E R RQ + A++ A K
Sbjct: 2239 ALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2297
Query: 274 LEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEA 333
L+E+ +A +EA R + Q K +E R+ +ED+++ A++ A
Sbjct: 2298 LKEKMQAVQEATRLKAEAELLQQQ-------------KELAQEQARRLQEDKEQMAQQLA 2344
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--EEKR 391
++ AE +R + + ++ + +++ + E + + KQ E E+
Sbjct: 2345 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2404
Query: 392 RTEEERKHK------LEMEKQEF----EQLRQEMGEEEEENETFGLSREYEEL-IKLKRS 440
RTE + K LE+++Q+ E+LR+ + E E E E L +E + L +K +
Sbjct: 2405 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--LQQEAKLLQLKSEEM 2462
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPA 500
++Q + L + + + Q E ++ ER +E ++ + E +++ +
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERF------IEQEKAKLEQLFQDEVAKAQQL 2516
Query: 501 RKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE- 559
R+ + + M+ +++ + EE +R+ E ++ +R +Q E+ Q++R++EE
Sbjct: 2517 REEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--KQEELQQLEQQRRQQEEL 2572
Query: 560 -EEEGSIMNGSTAEDEEQTRS 579
EE + EEQ R+
Sbjct: 2573 LAEENQRLREQLQLLEEQHRA 2593
Score = 66.6 bits (161), Expect = 7e-11
Identities = 124/631 (19%), Positives = 245/631 (38%), Gaps = 108/631 (17%)
Query: 3 DISQKAEILLSSSKPVPKTYVPKLG--KGDVKDKFEAMQRAREE-----RNQRRSRDE-- 53
++ + E L ++ VP T +P+L K +K K A A++ R++ R E
Sbjct: 1089 EVLRAHEEQLKEAQAVPAT-LPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVG 1146
Query: 54 ---KQRRKEQYIREREWNRRKQEIKE----MLASDD--EEDVSSKVEKAYVPKLTGTVKG 104
+QR E+ + W R ++ E +LA D + ++ + + + G
Sbjct: 1147 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1206
Query: 105 RFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEE 164
+ + ++RQE+ + + + + + + +++ + E+ + E++E+ + +
Sbjct: 1207 AWLQDARRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1265
Query: 165 GDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKC 224
D L + + + KK E +E + D R Y E
Sbjct: 1266 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV----DLRTHYSELT-------- 1313
Query: 225 LSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR-KKQAEEEARKRLEEEKRAFEE 283
+L+ +K E L R +E R +Q E R+RL E + A E+
Sbjct: 1314 ----------------TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1357
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA 343
R+ + + + K + E E Q+R E+ EEA +++K++
Sbjct: 1358 QRQ--------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1403
Query: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEEL----LKQKMEEEKRRTEEERKH 399
E + + ++ K E +L I EE+ L+ + E +R E
Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQ 1462
Query: 400 KLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSI--------QAKNLKSK 451
L +E E +++ EE E L R+ ++ + KR + +A+ + K
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAER-----LRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1517
Query: 452 FEKIGQLSEKEIQ--------KKIEEERARRRAIDLEIKEREAE--------NFHEED-- 493
+ L E +Q ++ E ERAR+ + LE +R AE +F E+
Sbjct: 1518 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1577
Query: 494 -DVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKL-------LRMQFEQR 545
+ ++ + A + +A+ + A+ EE +R +E +L LR+Q E+
Sbjct: 1578 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1637
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQ 576
+L + E+++EE + EEQ
Sbjct: 1638 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1668
Score = 57.0 bits (136), Expect = 6e-08
Identities = 98/486 (20%), Positives = 208/486 (42%), Gaps = 110/486 (22%)
Query: 33 DKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE----IKEMLASDDEEDVSS 88
++ E ++++ EE+ Q R++ + K + E+E RR Q +++ A+D E +
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2157
Query: 89 KV------EKAYVPKLTGTVKGRFAEMEKQR----QEEQRKR---TEEERKR-------- 127
K +KA V + T++ + E + Q+ +E QR + TE R+R
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2217
Query: 128 --RIEQDMLEKRKIQRELAKRAEQIEDINNTG------TESASEEGDDSLLITVVPVKSY 179
R++ + L K K + E RA + D +NT E + +++ ++V ++
Sbjct: 2218 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2277
Query: 180 KTSGKMKKNF-------EDLEKER----EEKERIKYE-----EDKRIRYEEQRPSLKEAK 223
+ +++ E + KE+ +E R+K E + K + E+ R ++ +
Sbjct: 2278 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2337
Query: 224 CLSLVMDDE-------IESEAKKE---SLSPGKLKLTFEELERQRQ------ENRKKQAE 267
++ + +E +E+E +++ S +LKL E+ R + + +KQAE
Sbjct: 2338 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2397
Query: 268 EEA-----------------------RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKG 304
E R++ + + EA ++ E E+ Q AK+
Sbjct: 2398 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--- 2454
Query: 305 YRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTI 364
L+L EEM+ ++E ++ + + + E+ +R ++ + ++ +
Sbjct: 2455 -----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL---QRERFIEQEKAKLEQLF 2506
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRT----EEERKHKLEMEK------QEFEQLRQE 414
E +L ++ +Q+ME+E++R EE R+ + E E+ +E +QL Q+
Sbjct: 2507 QDEVAKAQQLREE-QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2565
Query: 415 MGEEEE 420
++EE
Sbjct: 2566 RRQQEE 2571
Score = 53.5 bits (127), Expect = 6e-07
Identities = 87/407 (21%), Positives = 178/407 (43%), Gaps = 59/407 (14%)
Query: 31 VKDKFEAMQRA---REERNQRRSRDEKQRRKEQYIRER-EWNRRKQEIKEM--LASDDEE 84
+K + EA RA R++ N +R E+ + +Q E + QE + LA +D
Sbjct: 2229 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2288
Query: 85 DVSSKVEKAYVPKLTGT-------VKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR 137
+ EK K+ + + +K+ +EQ +R +E++++ +Q E +
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Query: 138 KIQREL-AKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKER 196
QR L A+R Q+E SA E + ++ + S + ED ++ R
Sbjct: 2349 GFQRTLEAERQRQLE-------MSAEAER--------LKLRVAEMSRAQARAEEDAQRFR 2393
Query: 197 EEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELER 256
++ E I + R L + ++LV EI+ + +L+ ELER
Sbjct: 2394 KQAEEIGEKL--------HRTELATQEKVTLVQTLEIQRQQSDHDAE--RLREAIAELER 2443
Query: 257 QRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEE 316
+++ K Q E + + EE Q V +++ Q+T + + + K L
Sbjct: 2444 EKE---KLQQEAKLLQLKSEEM--------QTVQQEQLLQETQALQQSFLSEKDSL---- 2488
Query: 317 MERQRR-EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE 375
++R+R E EK K E+ + + + ++ E +R + + +E + +
Sbjct: 2489 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQ 2545
Query: 376 INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEEN 422
EE +++K +EE ++ E++R+ + E+ +E ++LR+++ EE++
Sbjct: 2546 HEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2591
Score = 33.9 bits (76), Expect = 0.50
Identities = 64/281 (22%), Positives = 112/281 (39%), Gaps = 67/281 (23%)
Query: 318 ERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE-- 375
E +R E++KA+ E + + AEA + + + + SP S+ LT GKLE
Sbjct: 1004 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1063
Query: 376 -----INFEELL--------KQKMEEEKRRTEEERKH---------KLEMEKQEFEQLRQ 413
I E+L Q EE R EE+ K +LE K ++LR
Sbjct: 1064 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR- 1122
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERAR 473
+ E + TF R+ L+ E +L ++ ++ +E ER R
Sbjct: 1123 --AQAEAQQPTFDALRD----------------ELRGAQEVGERLQQRHGERDVEVERWR 1164
Query: 474 RRAIDL-----------EIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
R L ++++RE E + +R R+S P + A + +
Sbjct: 1165 ERVAQLLERWQAVLAQTDVRQRELEQLGRQ----LRYYRESADP------LGAWLQDARR 1214
Query: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQK-KREEEEEEE 562
+E+ + + + + +R Q Q + A L++ +R E+ EE
Sbjct: 1215 RQEQIQAMPLADSQAVREQLRQEQ--ALLEEIERHGEKVEE 1253
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 103 bits (257), Expect = 5e-22
Identities = 138/617 (22%), Positives = 263/617 (42%), Gaps = 85/617 (13%)
Query: 25 KLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEE 84
+L + + K +A + A+E Q+R ++E RR+E + ++ R QE + L E
Sbjct: 1401 QLAEAHAQAKAQAEREAKEL--QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1458
Query: 85 DVSSKVEKAYVP---KLTGTVKGRFAEMEKQRQEEQRKRTEEER---KRRIEQDMLEKRK 138
++ +K +A +L + R ++ + E QR E E + R E+ +KR+
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518
Query: 139 IQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE 198
Q E + Q++D + ++ E + ++K + E RE+
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVE-----------------LASRVKA---EAEAAREK 1558
Query: 199 KERIKYEEDKRIRYEEQRPSLKEAKC-LSLVMDDEIESEAKKESLSPGKLKLTFEELERQ 257
+ ++ E+ R++ EE L++A+ + + +E+ + + +F E Q
Sbjct: 1559 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1618
Query: 258 RQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEM 317
+ + +++ A+ R E E+RA ++A + E+ E + K +L+L EE+
Sbjct: 1619 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1678
Query: 318 ERQR------REDEKRKAEEEARRRIEEEKKAF-------AEARRNMVVDDDSPEMYKTI 364
+Q+ E +K +AE EARRR + E++A E + + + + +
Sbjct: 1679 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1738
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRTEEE------RKHKLEME----KQEFEQLRQE 414
QE + + E E +Q +EEE R + E ++ +LE E + E E L
Sbjct: 1739 EQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1797
Query: 415 MGEEEEENET------------FGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKE 462
EEE+ + G RE E R+ + +AK + E+ E
Sbjct: 1798 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857
Query: 463 IQKKIEEERAR-------RRAIDLEIKEREAENFHEE---DDVDVRPARKSEAPFTHKVN 512
++ + E+ A + ++ +KE+EAEN +D + R E HK +
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1917
Query: 513 MKARFEQMAKAREEEEQRR---IEEQKLLRMQFEQR--EIDAALQKK---REEEEEEEGS 564
++ R Q+ KA + E +R+ +E+ R Q E+ + A+ +K + E E E G
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
Query: 565 IMNGSTAEDEEQTRSGA 581
I S AED +++ A
Sbjct: 1978 IR--SNAEDTLRSKEQA 1992
Score = 95.1 bits (235), Expect = 2e-19
Identities = 139/615 (22%), Positives = 256/615 (41%), Gaps = 99/615 (16%)
Query: 39 QRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKL 98
+ A ER +R + DE +R+ E + + K +I+E LA K + + +
Sbjct: 1886 KEAENERLRRLAEDEAFQRRRL---EEQAAQHKADIEERLAQ------LRKASDSELERQ 1936
Query: 99 TGTVKGRFAEMEKQRQEEQRKRTEEE---RKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
G V+ QR++ EEE K E+ K +++ EL + ED
Sbjct: 1937 KGLVEDTL---------RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF---EDLEKER----EEKERIK--YEE 206
+ ++ E L + + +++K+ E+ ++R EE ER+K EE
Sbjct: 1988 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2047
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
+R+R ++ S ++ + +++E K + + + +E E Q+ +++
Sbjct: 2048 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQELQQTLQQEQSV 2102
Query: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE- 325
++ R E +RA EEA V + E + + + +LK S EE + R + +
Sbjct: 2103 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQA 2160
Query: 326 -----KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEE 380
+++AE+EA RR + E+ A R D E +K + E+
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFA-------------EQ 2203
Query: 381 LLKQKMEEEKRRTE-----EERKHKLEMEKQEFEQLRQEMGE-----EEEENETFGLSRE 430
L+QK + E+ T EE H+ + +E ++L+ E E + E E F + +
Sbjct: 2204 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263
Query: 431 YEELIKLKRSGSIQAKN--------------LKSKFEKIGQLSEKEIQKKI-EEERARRR 475
EEL KLK I+A+N L+ + EK+ Q++E+ + + +E AR R
Sbjct: 2264 MEELSKLK--ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321
Query: 476 AI---DLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRI 532
+ DL + AE +E V+ A + +A K ++ A+ R +E++ ++
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR-RLQEDKEQM 2380
Query: 533 EEQKLLRMQFEQREIDAALQKKREEEEEEEG--------SIMNGSTAEDEEQTRSGAPWF 584
+Q Q QR ++A Q++ E E E S ED ++ R A
Sbjct: 2381 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2440
Query: 585 KKPLKNTSVVDSEPV 599
+ L T + E V
Sbjct: 2441 GEKLHRTELATQEKV 2455
Score = 88.2 bits (217), Expect = 2e-17
Identities = 120/555 (21%), Positives = 241/555 (43%), Gaps = 63/555 (11%)
Query: 36 EAMQRAREERNQRRSRDEKQRR---KEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEK 92
+++ +A E+ + + E +RR +EQ +R+RE ++ E + LA + + E+
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-AEQ 1740
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE------RKRRIEQDMLEKR-KIQRELAK 145
+ T +G E ++Q EE+ R + E +++ +E ++ + R +++ LA
Sbjct: 1741 ELIRLRAETEQG---EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1797
Query: 146 RAEQIEDINNTGTESASEEGDDS-----LLITVVPVKSYKTSGKMKKNF--EDLEKEREE 198
+A E+ +T +S ++ L +++ K ++ ED ++R E
Sbjct: 1798 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857
Query: 199 KERIKYE------EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFE 252
ER+ E E R++ E + +LKE + ++ + A+ E+ +L E
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEI-ALKEKEA----ENERLRRLAEDEAFQRRRL----E 1908
Query: 253 ELERQRQ---ENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309
E Q + E R Q + + LE +K E+ RQ +EE F+ GK
Sbjct: 1909 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1968
Query: 310 LKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL 369
+L E + ++ +++E+A +++ AE R ++ + +E
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028
Query: 370 TPGKLEINFEELLKQKMEEEKR---RTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG 426
K + E LK K+EE +R R E+E +L++ ++ Q+ + EE+ F
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA----QEAAQKRLQAEEKAHAFA 2084
Query: 427 LSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREA 486
+ ++ +EL + + L+ + E + +E E E AR +A EREA
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------EAEEARVQA------EREA 2131
Query: 487 ENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE-EQKLLRMQFEQR 545
+ + R + +E + +A E++ K E+E RR + EQ LR +++
Sbjct: 2132 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQ 2188
Query: 546 EIDAALQKKREEEEE 560
DA ++K ++ E+
Sbjct: 2189 AADAEMEKHKKFAEQ 2203
Score = 88.2 bits (217), Expect = 2e-17
Identities = 118/561 (21%), Positives = 246/561 (43%), Gaps = 59/561 (10%)
Query: 43 EERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVE-KAYVPKLTGT 101
E RR+ +E + + Q RE +RR+ E E L EE ++ + +A KL
Sbjct: 2109 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2168
Query: 102 VKGRFA-----EMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNT 156
+ A E RQ++ E+ K+ EQ + +K ++++EL Q+E+
Sbjct: 2169 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2224
Query: 157 GTESASEEGDDSLL-ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQ 215
T+ D+ L + ++ + ++++ + + EE ++K RI E +
Sbjct: 2225 -TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK----ARIEAENR 2279
Query: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA--RKR 273
L++ + +E E + K+ + +L + +E R RQ + A++ A K
Sbjct: 2280 ALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338
Query: 274 LEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEA 333
L+E+ +A +EA R + Q K +E R+ +ED+++ A++ A
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQ-------------KELAQEQARRLQEDKEQMAQQLA 2385
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--EEKR 391
++ AE +R + + ++ + +++ + E + + KQ E E+
Sbjct: 2386 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2445
Query: 392 RTEEERKHK------LEMEKQEF----EQLRQEMGEEEEENETFGLSREYEEL-IKLKRS 440
RTE + K LE+++Q+ E+LR+ + E E E E L +E + L +K +
Sbjct: 2446 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--LQQEAKLLQLKSEEM 2503
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPA 500
++Q + L + + + Q E ++ ER +E ++ + E +++ +
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERF------IEQEKAKLEQLFQDEVAKAQQL 2557
Query: 501 RKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE- 559
R+ + + M+ +++ + EE +R+ E ++ +R +Q E+ Q++R++EE
Sbjct: 2558 REEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--KQEELQQLEQQRRQQEEL 2613
Query: 560 -EEEGSIMNGSTAEDEEQTRS 579
EE + EEQ R+
Sbjct: 2614 LAEENQRLREQLQLLEEQHRA 2634
Score = 66.6 bits (161), Expect = 7e-11
Identities = 124/631 (19%), Positives = 245/631 (38%), Gaps = 108/631 (17%)
Query: 3 DISQKAEILLSSSKPVPKTYVPKLG--KGDVKDKFEAMQRAREE-----RNQRRSRDE-- 53
++ + E L ++ VP T +P+L K +K K A A++ R++ R E
Sbjct: 1130 EVLRAHEEQLKEAQAVPAT-LPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVG 1187
Query: 54 ---KQRRKEQYIREREWNRRKQEIKE----MLASDD--EEDVSSKVEKAYVPKLTGTVKG 104
+QR E+ + W R ++ E +LA D + ++ + + + G
Sbjct: 1188 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1247
Query: 105 RFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEE 164
+ + ++RQE+ + + + + + + +++ + E+ + E++E+ + +
Sbjct: 1248 AWLQDARRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1306
Query: 165 GDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKC 224
D L + + + KK E +E + D R Y E
Sbjct: 1307 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV----DLRTHYSELT-------- 1354
Query: 225 LSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR-KKQAEEEARKRLEEEKRAFEE 283
+L+ +K E L R +E R +Q E R+RL E + A E+
Sbjct: 1355 ----------------TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1398
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA 343
R+ + + + K + E E Q+R E+ EEA +++K++
Sbjct: 1399 QRQ--------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1444
Query: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEEL----LKQKMEEEKRRTEEERKH 399
E + + ++ K E +L I EE+ L+ + E +R E
Sbjct: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQ 1503
Query: 400 KLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSI--------QAKNLKSK 451
L +E E +++ EE E L R+ ++ + KR + +A+ + K
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAER-----LRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1558
Query: 452 FEKIGQLSEKEIQ--------KKIEEERARRRAIDLEIKEREAE--------NFHEED-- 493
+ L E +Q ++ E ERAR+ + LE +R AE +F E+
Sbjct: 1559 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1618
Query: 494 -DVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKL-------LRMQFEQR 545
+ ++ + A + +A+ + A+ EE +R +E +L LR+Q E+
Sbjct: 1619 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1678
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQ 576
+L + E+++EE + EEQ
Sbjct: 1679 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1709
Score = 57.0 bits (136), Expect = 6e-08
Identities = 98/486 (20%), Positives = 208/486 (42%), Gaps = 110/486 (22%)
Query: 33 DKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE----IKEMLASDDEEDVSS 88
++ E ++++ EE+ Q R++ + K + E+E RR Q +++ A+D E +
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2198
Query: 89 KV------EKAYVPKLTGTVKGRFAEMEKQR----QEEQRKR---TEEERKR-------- 127
K +KA V + T++ + E + Q+ +E QR + TE R+R
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2258
Query: 128 --RIEQDMLEKRKIQRELAKRAEQIEDINNTG------TESASEEGDDSLLITVVPVKSY 179
R++ + L K K + E RA + D +NT E + +++ ++V ++
Sbjct: 2259 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2318
Query: 180 KTSGKMKKNF-------EDLEKER----EEKERIKYE-----EDKRIRYEEQRPSLKEAK 223
+ +++ E + KE+ +E R+K E + K + E+ R ++ +
Sbjct: 2319 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2378
Query: 224 CLSLVMDDE-------IESEAKKE---SLSPGKLKLTFEELERQRQ------ENRKKQAE 267
++ + +E +E+E +++ S +LKL E+ R + + +KQAE
Sbjct: 2379 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2438
Query: 268 EEA-----------------------RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKG 304
E R++ + + EA ++ E E+ Q AK+
Sbjct: 2439 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--- 2495
Query: 305 YRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTI 364
L+L EEM+ ++E ++ + + + E+ +R ++ + ++ +
Sbjct: 2496 -----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL---QRERFIEQEKAKLEQLF 2547
Query: 365 SQEFLTPGKLEINFEELLKQKMEEEKRRT----EEERKHKLEMEK------QEFEQLRQE 414
E +L ++ +Q+ME+E++R EE R+ + E E+ +E +QL Q+
Sbjct: 2548 QDEVAKAQQLREE-QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2606
Query: 415 MGEEEE 420
++EE
Sbjct: 2607 RRQQEE 2612
Score = 53.5 bits (127), Expect = 6e-07
Identities = 87/407 (21%), Positives = 178/407 (43%), Gaps = 59/407 (14%)
Query: 31 VKDKFEAMQRA---REERNQRRSRDEKQRRKEQYIRER-EWNRRKQEIKEM--LASDDEE 84
+K + EA RA R++ N +R E+ + +Q E + QE + LA +D
Sbjct: 2270 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2329
Query: 85 DVSSKVEKAYVPKLTGT-------VKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR 137
+ EK K+ + + +K+ +EQ +R +E++++ +Q E +
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Query: 138 KIQREL-AKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKER 196
QR L A+R Q+E SA E + ++ + S + ED ++ R
Sbjct: 2390 GFQRTLEAERQRQLE-------MSAEAER--------LKLRVAEMSRAQARAEEDAQRFR 2434
Query: 197 EEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELER 256
++ E I + R L + ++LV EI+ + +L+ ELER
Sbjct: 2435 KQAEEIGEKL--------HRTELATQEKVTLVQTLEIQRQQSDHDAE--RLREAIAELER 2484
Query: 257 QRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEE 316
+++ K Q E + + EE Q V +++ Q+T + + + K L
Sbjct: 2485 EKE---KLQQEAKLLQLKSEEM--------QTVQQEQLLQETQALQQSFLSEKDSL---- 2529
Query: 317 MERQRR-EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE 375
++R+R E EK K E+ + + + ++ E +R + + +E + +
Sbjct: 2530 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQ 2586
Query: 376 INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEEN 422
EE +++K +EE ++ E++R+ + E+ +E ++LR+++ EE++
Sbjct: 2587 HEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2632
Score = 33.9 bits (76), Expect = 0.50
Identities = 64/281 (22%), Positives = 112/281 (39%), Gaps = 67/281 (23%)
Query: 318 ERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE-- 375
E +R E++KA+ E + + AEA + + + + SP S+ LT GKLE
Sbjct: 1045 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1104
Query: 376 -----INFEELL--------KQKMEEEKRRTEEERKH---------KLEMEKQEFEQLRQ 413
I E+L Q EE R EE+ K +LE K ++LR
Sbjct: 1105 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR- 1163
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERAR 473
+ E + TF R+ L+ E +L ++ ++ +E ER R
Sbjct: 1164 --AQAEAQQPTFDALRD----------------ELRGAQEVGERLQQRHGERDVEVERWR 1205
Query: 474 RRAIDL-----------EIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
R L ++++RE E + +R R+S P + A + +
Sbjct: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGRQ----LRYYRESADP------LGAWLQDARR 1255
Query: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQK-KREEEEEEE 562
+E+ + + + + +R Q Q + A L++ +R E+ EE
Sbjct: 1256 RQEQIQAMPLADSQAVREQLRQEQ--ALLEEIERHGEKVEE 1294
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 102 bits (253), Expect = 2e-21
Identities = 101/395 (25%), Positives = 193/395 (48%), Gaps = 57/395 (14%)
Query: 36 EAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYV 95
E ++ RE+ + R ++EK RR+E+ + E+E R+QE EM+ ++E+ ++E+
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE--EMMW--EKEEKMRRLEEMMW 373
Query: 96 PKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
K + + E+E ++ EQ K E+E KR+ E+ + E+ K Q + AK Q E I
Sbjct: 374 EK-----EEKIRELE-EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 427
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEE----DKRIR 211
+ +E K + ++ + EK REE++R + EE +++IR
Sbjct: 428 QEEKIREQE---------------KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR 472
Query: 212 YEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEAR 271
+E+ KE M ++ + ++E + + K+ +E + + QE + + EE+ R
Sbjct: 473 EQEEIWRQKEK------MHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIR 526
Query: 272 KRLEEEKRAFEEARRQ--MVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKA 329
++ E+ + E+ R Q M+ E EE + G+ + +E E+ RR++EK +
Sbjct: 527 EQEEKIREQEEKIREQEEMMQEQEE-----------KMGEQEEKMQEQEKMRRQEEKIRE 575
Query: 330 EEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEE 389
+EE +I E+K+ E + ++ K QE + + E +E+ K +EE
Sbjct: 576 QEE---KIREQKEKIREQEEKIWEQEE-----KIREQEEMMQEQEEKMWEQEEKMCEQEE 627
Query: 390 KRRTEEERKHKLEMEKQEFE-QLRQEMGEEEEENE 423
K + +EE+ + E + E E +LRQ+ + +E E
Sbjct: 628 KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 100 bits (249), Expect = 4e-21
Identities = 106/461 (22%), Positives = 227/461 (49%), Gaps = 28/461 (6%)
Query: 110 EKQRQEEQRKRTEEERKRRIEQDMLE-KRKIQR-ELAKRAEQIE-DINNTGTESASEEGD 166
EK + +++ + E K I+ ++ E KRK++R +L +Q++ + ++ G E S
Sbjct: 221 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280
Query: 167 DSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLS 226
+ + + + +K + EK +E +E+I+ +E+K IR +E++ +E K
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEK-IREQEEKIREQEEK--- 336
Query: 227 LVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARR 286
M + E +KE + ++ +E+ E+ R+ +EE + LEE+ E+ R
Sbjct: 337 --MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIRE 394
Query: 287 QMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAE 346
Q +E+ Q+ KI + + + + E + RE E++ E+E + +EEK E
Sbjct: 395 Q----EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 450
Query: 347 ARRNMVVDDDSPEMY----KTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLE 402
R + EM+ K QE + K +++ +E ++++ E+ R+ E+ + +
Sbjct: 451 KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEK 510
Query: 403 MEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEK- 461
+ +QE + RQE E+E + RE EE I+ Q + ++ + EK+G+ EK
Sbjct: 511 IREQEEKMWRQEEKIREQEEKI----REQEEKIR------EQEEMMQEQEEKMGEQEEKM 560
Query: 462 EIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMA 521
+ Q+K+ + + R + +I+E++ + +E+ + + + E + + +EQ
Sbjct: 561 QEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE 620
Query: 522 KAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEE 562
K E+EE+ + +E+K+ R + + E + L+++ E+ +E +
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661
Score = 96.7 bits (239), Expect = 6e-20
Identities = 117/542 (21%), Positives = 244/542 (45%), Gaps = 29/542 (5%)
Query: 52 DEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEK 111
++K + Q RE + I+ + E ++ + V +L G + + +
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 169
Query: 112 QRQEEQRKRTEEERKRRIEQDMLEKRKIQR---ELAKRAE--QIEDINNTGTESASEEGD 166
+ E ++ + +K+K R EL K + +E NT T+ +E +
Sbjct: 170 SW------KFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 223
Query: 167 DSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKE--AKC 224
L + V+S K+ +++ N ++L+++ E + + ++ + + L+ AK
Sbjct: 224 AKLQEKLQLVESEKS--EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 281
Query: 225 LSLVMDDEIESEAKKESLSP-GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEE 283
+ V ++E+ + ++ + + +E E + QE +K E+E + R +EEK +E
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQE 341
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA 343
E Q+ K + +L+ E E + RE E++ E+E R EE+++
Sbjct: 342 EMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE 401
Query: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKM---EEEKRRTEEERKHK 400
+ R + +M++ + K+ +++ +Q+ E+EK R EE+R+ +
Sbjct: 402 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ 461
Query: 401 LEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSE 460
EM +QE +++ E+EE E E++ K + Q + + + EKI + E
Sbjct: 462 EEMWRQE-----EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE 516
Query: 461 K--EIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFE 518
K ++KI E+ + R + +I+E+E +E+ + + + E + K R E
Sbjct: 517 KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIR-E 575
Query: 519 QMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREE--EEEEEGSIMNGSTAEDEEQ 576
Q K RE++E+ R +E+K+ + + RE + +Q++ E+ E+EE+ E EE+
Sbjct: 576 QEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 635
Query: 577 TR 578
R
Sbjct: 636 MR 637
Score = 96.3 bits (238), Expect = 8e-20
Identities = 113/516 (21%), Positives = 234/516 (45%), Gaps = 47/516 (9%)
Query: 54 KQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQR 113
++++ ++YI E R ++ + +E++ K K ++ + +E ++
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK---------LQEKLQLVESEK 237
Query: 114 QEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITV 173
E Q E +RK + +L ++++Q E ++++ ++ E + L
Sbjct: 238 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQ 297
Query: 174 VPVKSYKTSGKMK----KNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVM 229
K ++ K++ K E EK RE++E+I+ +E+K R EE +E M
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM 357
Query: 230 DDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEAR----KRLEEEKRAFEEAR 285
E E + ++ + + ELE + E K + +EE R K E+EKR +EA+
Sbjct: 358 MWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 417
Query: 286 RQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFA 345
E Q+ + + + + E E+ R E+EKR+ +EE R+ EE+ +
Sbjct: 418 MWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR-EEEKRQEQEEMWRQ-EEKIREQE 475
Query: 346 EARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEK 405
E R + ++ K + + K+ E++ +Q EE+ R EE+ + + E +
Sbjct: 476 EIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ--EEKMWRQEEKIREQEEKIR 533
Query: 406 QEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEK--EI 463
++ E++R++ +E+ E G E EE ++ + Q + ++ + EKI + EK E
Sbjct: 534 EQEEKIREQEEMMQEQEEKMG---EQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQ 590
Query: 464 QKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKA 523
++KI E+ + R + ++E+E + + +E+ + EQ K
Sbjct: 591 EEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM---------------------CEQEEKM 629
Query: 524 REEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE 559
+E+EE+ R +E+K+ + R+ + +Q+ +E E
Sbjct: 630 QEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 77.8 bits (190), Expect = 3e-14
Identities = 75/315 (23%), Positives = 153/315 (48%), Gaps = 42/315 (13%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSK 89
++++K ++ RE+ E++R++E+ IRE+E R++QE K + + K
Sbjct: 381 ELEEKMHEQEKIREQ--------EEKRQEEEKIREQE-KRQEQEAKMWRQEEKIREQEEK 431
Query: 90 VEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQ 149
+ + K + + E EK R+EE KR E+E R E+ + E+ +I R+ K EQ
Sbjct: 432 IREQ--EKKMWRQEEKIHEQEKIREEE--KRQEQEEMWRQEEKIREQEEIWRQKEKMHEQ 487
Query: 150 IEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKR 209
E I + +E + + K + +K + EK RE++E+I+ E++++
Sbjct: 488 -EKIRKQEEKVWRQE-------EKMHDQEEKIREQEEKMWRQEEKIREQEEKIR-EQEEK 538
Query: 210 IRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEE- 268
IR +E+ +E K M ++ E ++E + + K+ +E + + Q+ + ++ EE
Sbjct: 539 IREQEEMMQEQEEK-----MGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEK 593
Query: 269 --EARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEK 326
E +++ E++ +E +M ++E+ + + +E E + R E+
Sbjct: 594 IWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE------------KMQEQEEKMRRQEE 641
Query: 327 RKAEEEARRRIEEEK 341
+ E+E R R +EEK
Sbjct: 642 KMWEQEVRLRQQEEK 656
Score = 74.7 bits (182), Expect = 3e-13
Identities = 64/279 (22%), Positives = 136/279 (48%), Gaps = 23/279 (8%)
Query: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE--------IKEMLA 79
K ++K ++ +E+ + ++EK R +E+ IRE+E +QE I+E
Sbjct: 398 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 457
Query: 80 SDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR-K 138
++E++ + EK + K + E EK R++E++ +EE+ E+ + E+ K
Sbjct: 458 RQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEK 517
Query: 139 IQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE 198
+ R+ K EQ E I + +E + + + G+ ++ ++ EK R +
Sbjct: 518 MWRQEEKIREQEEKIREQEEKIREQEE--------MMQEQEEKMGEQEEKMQEQEKMRRQ 569
Query: 199 KERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQR 258
+E+I+ +E+K EQ+ ++E + + + E + ++E + + K+ +E+ E+
Sbjct: 570 EEKIREQEEK---IREQKEKIREQE--EKIWEQEEKIREQEEMMQEQEEKM-WEQEEKMC 623
Query: 259 QENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQD 297
++ K Q +EE +R EE+ E RQ + +E+Q+
Sbjct: 624 EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 73.2 bits (178), Expect = 8e-13
Identities = 86/392 (21%), Positives = 167/392 (42%), Gaps = 62/392 (15%)
Query: 193 EKEREEKERIKYEEDKR----IRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLK 248
EK + +E+++ E ++ + +E + L+ AK L + E++ + L K
Sbjct: 221 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280
Query: 249 LTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPG 308
L ++E NR Q +EE R EE+ + +EE ++ + E ++ + +
Sbjct: 281 LQ-AQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339
Query: 309 KLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEF 368
+ ++ +E+ E+ RR++E +EE RR+EE E R
Sbjct: 340 QEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIR------------------- 380
Query: 369 LTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLS 428
+LE E K + +EEKR+ EE+ + + + ++QE + RQE E+E +
Sbjct: 381 ----ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI---- 432
Query: 429 REYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAEN 488
RE E K + + EKI + Q+KI EE R+ + E R+ E
Sbjct: 433 REQE-------------KKMWRQEEKIHE------QEKIREEEKRQ---EQEEMWRQEEK 470
Query: 489 FHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREID 548
E++++ + + E K Q K +EE+ +E+K+ + + +
Sbjct: 471 IREQEEIWRQKEKMHEQEKIRK--------QEEKVWRQEEKMHDQEEKIREQEEKMWRQE 522
Query: 549 AALQKKREEEEEEEGSIMNGSTAEDEEQTRSG 580
++++ E+ E+E I E++ + G
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMG 554
Score = 63.5 bits (153), Expect = 6e-10
Identities = 102/443 (23%), Positives = 186/443 (41%), Gaps = 45/443 (10%)
Query: 133 MLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLL--ITVVPVKSYKTSGKMKKNFE 190
M+ K Q +LA+ EQ+ D + S D+ I TSG +
Sbjct: 50 MMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPED 109
Query: 191 DLEKEREEKERIKYEEDKRIRYEE----QRPSLKEAKCLSLVMDDEIESEAKKESLSPGK 246
+ + + +E ++ E + ++ Q+ L+ A S ++E EA+ + +S
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR-DLISRLH 168
Query: 247 LKLTFE-ELERQRQE--NRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFK 303
F ELE+ +KK+A+ + +E E R + ++E + AK+ +
Sbjct: 169 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 228
Query: 304 GYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKT 363
KL E E+ E + +E +R++E K + + D E+
Sbjct: 229 -------KLQLVESEKS----EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 277
Query: 364 ISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENE 423
+ KL+ EE ++ + +EE+ + E + QE+E+ QE E+ E E
Sbjct: 278 SA-------KLQAQVEE---NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 424 TFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKE 483
RE EE K++R Q + + K EK+ + E +K+ + R + E K
Sbjct: 328 E--KIREQEE--KMRR----QEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKI 379
Query: 484 REAEN-FHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQ- 541
RE E HE++ + + ++ E + + R EQ AK +EE+ R +E+K+ +
Sbjct: 380 RELEEKMHEQEKIREQEEKRQEEEKIRE--QEKRQEQEAKMWRQEEKIREQEEKIREQEK 437
Query: 542 --FEQREIDAALQKKREEEEEEE 562
+ Q E +K REEE+ +E
Sbjct: 438 KMWRQEEKIHEQEKIREEEKRQE 460
Score = 48.1 bits (113), Expect = 3e-05
Identities = 54/272 (19%), Positives = 118/272 (43%), Gaps = 41/272 (15%)
Query: 325 EKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLT----PGKLEINFEE 380
+K+KA+ +E E RN + D++ E + ++ ++++N +E
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 246
Query: 381 LLKQKMEEEKRRTEEER-KHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKR 439
L K+K+E K +++ + + + +E + + ++ + EENE + + +E
Sbjct: 247 L-KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE------ 299
Query: 440 SGSIQAKNLKSKFEKIGQLSEK--EIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDV 497
EK+ + EK E ++KI+E+ + R + +I+E+E +
Sbjct: 300 -------------EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK---------- 336
Query: 498 RPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREE 557
R+ E K R E+M E+EE+ R E+ + + + RE++ + ++ +
Sbjct: 337 --MRRQEEMMWEKEEKMRRQEEMMW--EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKI 392
Query: 558 EEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLK 589
E+EE E E++ A +++ K
Sbjct: 393 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 424
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/131 (25%), Positives = 68/131 (51%), Gaps = 21/131 (16%)
Query: 25 KLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEE 84
K+G+ + K + + R +EE+ R ++EK R +++ IRE+E +QE K + EE
Sbjct: 552 KMGEQEEKMQEQEKMRRQEEK--IREQEEKIREQKEKIREQEEKIWEQEEK---IREQEE 606
Query: 85 DVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEK----RKIQ 140
+ + EK + + EK ++E++ + +EE+ RR E+ M E+ R+ +
Sbjct: 607 MMQEQEEKMW------------EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQE 654
Query: 141 RELAKRAEQIE 151
++ + E +E
Sbjct: 655 EKMQEHQEHLE 665
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 99.8 bits (247), Expect = 7e-21
Identities = 119/540 (22%), Positives = 241/540 (44%), Gaps = 42/540 (7%)
Query: 37 AMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVP 96
A+ R +E + + + R + I E + + ++ A + D+S ++E A
Sbjct: 1095 ALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELE-ALKT 1153
Query: 97 KLTGTVKGRFAEMEKQRQEEQ-----RKRTEEERKRRIEQ--DM-------LEKRKIQRE 142
+L T+ A+ E + + EQ +K EEE K Q DM LE+ Q E
Sbjct: 1154 ELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLE 1213
Query: 143 LAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERI 202
AKR + + N G E+ ++E L V ++ K + K+ D + + +
Sbjct: 1214 QAKRFKANLEKNKQGLETDNKE----LACEVKVLQQVKAESEHKRKKLDAQVQ---ELHA 1266
Query: 203 KYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR 262
K E R+R E + K L V + EA+K+ + K LE Q Q+ +
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNV--STLLEEAEKKGI---KFAKDAASLESQLQDTQ 1321
Query: 263 KKQAEEEARK-RLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQR 321
+ EE +K L R EE + + + EE ++ K L L + + ++
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK---NLEKQVLALQSQLADTKK 1378
Query: 322 REDEKR---KAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINF 378
+ D+ ++ EEA++++ ++ +A ++ + D E K Q+ L ++++
Sbjct: 1379 KVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Query: 379 EELLKQKMEEEKRRTEEERKHKLEMEKQEFEQL-RQEMGEEEEENETFGLSREYEELIKL 437
+ + +E+++++ ++ + + + E+ R E E+E + L+R EE ++
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 438 KRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDV 497
K Q K L++ E + S+ ++ K + E +RA++ +++E + ED++
Sbjct: 1499 KEEFERQNKQLRADMEDL-MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQA 1557
Query: 498 RPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREE 557
K + MKA+FE+ + R+E+ + E+++LL Q RE++A L+ +R++
Sbjct: 1558 TEDAKLRLEVNMQA-MKAQFERDLQTRDEQNE---EKKRLLIKQV--RELEAELEDERKQ 1611
Score = 90.9 bits (224), Expect = 3e-18
Identities = 131/527 (24%), Positives = 233/527 (44%), Gaps = 80/527 (15%)
Query: 6 QKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREER--NQRRSRDEKQRRKEQYIR 63
+K + LL+ K + Y + +D+ EA R +E + + R+ +E KE++
Sbjct: 1451 KKFDQLLAEEKSISARYAEE------RDRAEAEAREKETKALSLARALEEALEAKEEF-- 1502
Query: 64 EREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQE-EQRKRTE 122
ER+ + + +++++++S D DV V + + K ++ + EM Q +E E +
Sbjct: 1503 ERQNKQLRADMEDLMSSKD--DVGKNVHE--LEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 123 EERKRRIEQDMLE-KRKIQRELAKRAEQIEDINNTGTESASE---EGDDSLLITVVPVKS 178
E+ K R+E +M K + +R+L R EQ E+ + E E +D + V S
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618
Query: 179 YKTSGKMKKNFEDLEKEREEKERIKYEEDKRIR-----YEEQRPSLKEAKCLSLVMDDEI 233
K KM+ + +DLE + E + + E K++R ++ + L+EA+ DEI
Sbjct: 1619 KK---KMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASR----DEI 1671
Query: 234 -----ESEAKKESLSPGKLKL-----TFEELERQRQENRKKQAEE-----EARKRLEEEK 278
ESE K +SL L+L + E R ++ R + A+E + L +EK
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 279 RAFEEARRQMVNEDEENQDTAKIFKG-YRPGKLKLSFEEMERQRREDEKRKAEEEARRRI 337
R E Q+ E EE Q ++ +R L++ E +K++ AR+++
Sbjct: 1732 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDN-ARQQL 1790
Query: 338 EEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEK--RRTE- 394
E + K +A+ + + TIS G+LE E+ K++ K RRTE
Sbjct: 1791 ERQNKEL-KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEK 1849
Query: 395 ----------EERKH----KLEMEKQE--FEQLRQEMGEEEEENETFG-----LSREYEE 433
+ER+H K +MEK +QL++++ E EEE L RE ++
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Query: 434 LIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLE 480
+ S + LK++ + G +S R+ RR + LE
Sbjct: 1910 ATEANEGLSREVSTLKNRLRRGGPIS-------FSSSRSGRRQLHLE 1949
Score = 86.3 bits (212), Expect = 9e-17
Identities = 135/619 (21%), Positives = 265/619 (42%), Gaps = 106/619 (17%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSK 89
D D A Q R +R Q + +K +E E + +Q L E+ +K
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 90 VEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRR--------IEQDMLEKRKIQR 141
KA + K ++ E+ + + Q+ + E E KR+ + + E +++
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV 1276
Query: 142 ELAKRAEQIE-DINNTGT--ESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE 198
ELA++A +++ +++N T E A ++G +K K + ++ +D ++ +E
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKG----------IKFAKDAASLESQLQDTQELLQE 1326
Query: 199 KERIKYEEDKRIRY-EEQRPSLKEAKCLSLVMDDEIESE--AKKESLSPGKLKL-----T 250
+ R K RIR EE++ SL+E + +E + A + L+ K K+ T
Sbjct: 1327 ETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGT 1386
Query: 251 FEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQM-----------VNEDEENQDTA 299
E LE +++ K E +RLEE+ A+++ + V+ D + Q +
Sbjct: 1387 IESLEEAKKKLLKDA--EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVAS 1444
Query: 300 KIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPE 359
+ K + L+ E+ R +E+ +AE EAR E+E KA + AR + E
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR---EKETKALSLAR--------ALE 1493
Query: 360 MYKTISQEFLTPGK-LEINFEELLKQKMEEEKRRTE-EERKHKLEMEKQEFEQLRQEMGE 417
+EF K L + E+L+ K + K E E+ K LE + +E +E+ +
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 418 EEEENETFGLSREYE-ELIKLKRSGSIQAKNLKSKFEKIGQLSE-KEIQKKIEEERARRR 475
E + E L E + +K + +Q ++ +++ +K + + +E++ ++E+ER +R
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Query: 476 A---------IDLEIKEREAENFHEEDDVDVRPARKSEAPFTH-----KVNMKARFEQMA 521
IDL+ E + E ++ D ++ RK +A + +R E A
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 522 KAREEEEQRRIEEQKLLRMQFE-----------------------------------QRE 546
+++E E++ + E ++L++Q E +R
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733
Query: 547 IDAALQKKREEEEEEEGSI 565
++A + + EE EEE+ ++
Sbjct: 1734 LEARIAQLEEELEEEQSNM 1752
Score = 81.6 bits (200), Expect = 2e-15
Identities = 129/629 (20%), Positives = 274/629 (43%), Gaps = 70/629 (11%)
Query: 31 VKDKFEAMQRAREERNQRRSR--DEKQRRKEQYIREREWNRRKQEIKEMLASDDEE---- 84
VK+K ++ EE ++ + +EK EQ E E +E++ LA+ +E
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI 923
Query: 85 --DVSSKVEKA-----YVPKLTGTVKGRFAEMEKQRQEEQRKR--------TEEERKRRI 129
D+ S+VE+ + ++ ++E+Q EE+ R T E + +++
Sbjct: 924 LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKM 983
Query: 130 EQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF 189
E+++L + K + +ED + +EE + + + + K +++
Sbjct: 984 EEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL 1043
Query: 190 EDLEKEREEKERIKYE-----EDKRIRYEEQRPSLKEAKCLSLVMDDEIE---SEAKKES 241
+ EK R+E E+ K + D + + E + + E K ++E++ + E+
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDET 1103
Query: 242 LSPGKLKLTFEELERQRQENRKK-QAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAK 300
L EL+ Q E ++ ++E+ +R + E++KR E + E E+ DT
Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163
Query: 301 IFKGYRP------GKLKLSFEE----MERQRREDEKRKAE--EEARRRIEEEKKAFAEAR 348
+ R +LK + EE E Q ++ +R A EE ++E+ K+ A
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223
Query: 349 RN-MVVDDDSPEM---YKTISQEFLTP----GKLEINFEELLKQKMEEEKRRTE-EERKH 399
+N ++ D+ E+ K + Q KL+ +EL + E ++ R E E+
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283
Query: 400 KLEMEKQEFEQLRQEMGEE--EEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQ 457
KL+ E L +E ++ + + L + ++ +L + + Q NL S+ ++ +
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343
Query: 458 LSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVD--------VRPARKSEAPFTH 509
+ +Q++ EEE R+ ++ ++ +++ + VD + A+K
Sbjct: 1344 -EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402
Query: 510 KVNMKARFEQMAKAREEEEQRRIEEQ--KLLRMQFEQREIDAALQKKREEEEE---EEGS 564
++ + + +A + E+ + R++++ L QR++ + L+KK+++ ++ EE S
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS 1462
Query: 565 IMNGSTAEDEEQTRSGAPWFKKPLKNTSV 593
I S EE+ R+ A +K K S+
Sbjct: 1463 I---SARYAEERDRAEAEAREKETKALSL 1488
Score = 45.8 bits (107), Expect = 1e-04
Identities = 44/190 (23%), Positives = 91/190 (47%), Gaps = 24/190 (12%)
Query: 373 KLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYE 432
+L+ EELLK K E++ K+E E +E E+ Q++ EE+ L+ + +
Sbjct: 853 ELQAKDEELLKVK----------EKQTKVEGELEEMERKHQQLLEEKNI-----LAEQLQ 897
Query: 433 ELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEE 492
+L L +K +++ ++ +++ ++EEE R + + E K+ +A E
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILH-DLESRVEEEEERNQILQNEKKKMQAHIQDLE 956
Query: 493 DDVDVRPARKSEAPFTHKVNMKARFEQMAK---AREEEEQRRIEEQKLLRMQFEQREIDA 549
+ +D + + KV +A+ ++M + E++ + I+E+KL+ E R +
Sbjct: 957 EQLDEEEGARQKLQL-EKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM----EDRIAEC 1011
Query: 550 ALQKKREEEE 559
+ Q EEE+
Sbjct: 1012 SSQLAEEEEK 1021
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 98.2 bits (243), Expect = 2e-20
Identities = 149/615 (24%), Positives = 262/615 (42%), Gaps = 98/615 (15%)
Query: 30 DVKDKFEAMQRAREERNQ-----RRSRDEKQRRKEQYIREREWNRRK--QEIKEMLASDD 82
D D Q R +R Q +++ DE+ R E ++E + +E+ E L
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 83 EEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQE-EQRKRTEEERKRRIEQDMLEKRKIQR 141
+ K + K + G + + +QE E +K+ E + + ++ + + +
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276
Query: 142 ELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKER 201
EL + ++++ + T +E + +K K + +D ++ +E+ R
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKA-------IKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 202 IKYEEDKRIRY-EEQRPSLKEAKCLSLVMDDEIESEAKKE--------SLSPGKLKL--- 249
K ++R EE+R SL++ +D+E+E++ E LS K KL
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQ------LDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Query: 250 --TFEELERQRQ------ENRKKQAEEEARK--RLEEEK-RAFEEARRQMVNEDEENQDT 298
T E LE ++ EN +Q EE+A +LE+ K R +E +V+ D + Q
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443
Query: 299 AKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSP 358
+ + K R L+ E+ + DE+ +AE EAR E+E KA + AR +
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKETKALSLARALEEALEAKE 1500
Query: 359 EMYKT-----ISQEFLTPGKLEI--NFEELLKQK------MEEEKRRTEE---------E 396
E+ +T E L K ++ N EL K K MEE K + EE +
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 397 RKHKLEMEKQ----EFEQLRQEMGEEEEENETFGLSR---EYEELIKLKRSGSIQAKNLK 449
K +LE+ Q +FE+ Q E+ EE L R EYE ++ +R A K
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETELEDERKQRALAAAAK 1619
Query: 450 SKFEKIGQLSEKEIQ-----KKIEEERARRRAIDLEIKE--REAENFHEEDDVDVRPARK 502
K E G L + E+Q K EE + R + ++K+ RE E+ D A++
Sbjct: 1620 KKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1677
Query: 503 SEAPFTH-KVNMKARFEQMAKAREEEEQRRIEEQKLLR-----------MQFEQREIDAA 550
+E + ++ E +A A +Q +E+++L +Q E+R ++A
Sbjct: 1678 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1737
Query: 551 LQKKREEEEEEEGSI 565
+ + EE EEE+G++
Sbjct: 1738 IAQLEEELEEEQGNM 1752
Score = 79.3 bits (194), Expect = 1e-14
Identities = 137/640 (21%), Positives = 261/640 (40%), Gaps = 122/640 (19%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRK-----EQYIREREWNRRKQEIK--------- 75
++ + EA E+R Q+ + K+ + E+ + E E R+K +++
Sbjct: 922 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 76 ----EMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQ------------EEQRK 119
E+L DD+ + SK K +++ E EK + E
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 120 RTEEERKRRIEQDMLEKRKIQRELAKRAEQIED----INNTGTESASEEGDDSLLITVVP 175
R ++E K R E + L KRK++ + + EQI D I + A +E + + +
Sbjct: 1042 RLKKEEKSRQELEKL-KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 176 VKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSL-KEAKCLSLVMDDEIE 234
+ + + +KK E + +E + E R + E+Q+ L +E + L ++D ++
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160
Query: 235 SEAKKESLSPGK------LKLTFEE----LERQRQENRKK--QAEEEARKRLEEEKRAFE 282
S A ++ L + LK +E E Q QE R+K QA EE ++LE+ KRA
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 283 EARRQMVNEDEENQD---------TAKIFKGYRPGKLKLSFEEMERQRREDEKRKAE-EE 332
+ ++EN D AK ++ KL+ +E++ + + E+ +AE +
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 333 ARRRIEEEKKAF------AEARRNMVVDD---------DSPEMYKTISQEFLTPGKLEIN 377
+++ E ++ AE + + D D+ E+ + +++ L
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 378 FEE---LLKQKMEEEKRRTEEERKH------KLEMEKQEFEQLRQ-----EMGEEEEENE 423
EE L+ +++EE + +H +L K++ + E G++ + E
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 424 TFGLSREYEELIKL-----KRSGSIQ----------------AKNLKSKFEKIGQL--SE 460
L+++YEE K +Q NL+ K K QL E
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 461 KEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQM 520
K I K +ER R A E +E+E + ++ K E T+K+ +KA E +
Sbjct: 1461 KNISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKM-LKAEMEDL 1516
Query: 521 AKAREE--------EEQRRIEEQKLLRMQFEQREIDAALQ 552
++++ E+ +R E ++ M+ + E++ LQ
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Score = 79.0 bits (193), Expect = 1e-14
Identities = 119/507 (23%), Positives = 213/507 (42%), Gaps = 75/507 (14%)
Query: 6 QKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREER--NQRRSRDEKQRRKEQYIR 63
+K + LL+ K + Y D +D+ EA R +E + + R+ +E KE+
Sbjct: 1451 RKFDQLLAEEKNISSKYA------DERDRAEAEAREKETKALSLARALEEALEAKEEL-- 1502
Query: 64 EREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQE-EQRKRTE 122
ER K E++++++S D DV V + + K ++ + EM+ Q +E E +
Sbjct: 1503 ERTNKMLKAEMEDLVSSKD--DVGKNVHE--LEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 123 EERKRRIEQDMLE-KRKIQRELAKRAEQIED----INNTGTESASEEGDDSLLITVVPVK 177
E+ K R+E +M K + +R+L R EQ E+ + E +E D+ +
Sbjct: 1559 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618
Query: 178 SYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIR-----YEEQRPSLKEAKCLSLVMDDE 232
K G +K DLE + + + + E K++R ++ + L++A+ DE
Sbjct: 1619 KKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR----DE 1670
Query: 233 I-----ESEAKKESLSPGKLKL-----TFEELERQRQENRKKQAEEEA-----RKRLEEE 277
I E+E K +SL ++L E +Q +++ AEE A R L++E
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 278 KRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQ-RREDEKRKAEEEARRR 336
KR E Q+ E EE Q + R K E++ + E + E AR++
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSD-RVRKATQQAEQLSNELATERSTAQKNESARQQ 1789
Query: 337 IEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--------- 387
+E + K M S + TI+ +LE E+ ++K
Sbjct: 1790 LERQNKELRSKLHEMEGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 388 ----------EEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG-----LSREYE 432
E++R+ E+ K + E +QL++++ E EEE++ L RE +
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908
Query: 433 ELIKLKRSGSIQAKNLKSKFEKIGQLS 459
E + + + LKSK + + S
Sbjct: 1909 EATESNEAMGREVNALKSKLRRGNETS 1935
Score = 74.3 bits (181), Expect = 3e-13
Identities = 126/648 (19%), Positives = 276/648 (42%), Gaps = 96/648 (14%)
Query: 38 MQRAREERNQRRSRDEKQRRKEQY------IREREWNR---------------------- 69
+Q R+E + DE Q+ KE+ ++E E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 70 -----------RKQEIKEMLAS-----DDEEDVSSKV--EKAYVPKLTGTVKGRFAEMEK 111
+KQE++E+L ++EED ++ E+ + + ++ + E E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 112 QRQEEQ-RKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLL 170
RQ+ Q K T E + +++E ++L +L+K + +E+ + T + +EE + +
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 171 ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYE-EDKRIRYEEQ----RPSLKEAKCL 225
+T + K +++ + EK R+E E++K + E + EQ + + E K
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 226 SLVMDDEIESEAKK---ESLSPGKLKLTFEELERQRQENRKK-QAEEEARKRLEEEKRAF 281
++E+++ + E ELE + ++ +E AR + E++KR
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 282 EEARRQMVNEDEENQDTAKIFKGYRPGK------LKLSFEEMER--QRREDEKRKAEEEA 333
E + E E+ D+ + R + LK + +E R + + E R+ +A
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKT-ISQEFLTPG-----------KLEINFEEL 381
+ E+ + F A+ N+ + + E ++ E G KLE +EL
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 382 LKQKMEEEKRRTE-EERKHKLEMEKQEFEQLRQEMGEEEEE-----NETFGLSREYEELI 435
+ + E+ R E ++ HKL+ E E + + E E + + LS + ++
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQ---NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 436 KLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAID-----LEIKEREAENFH 490
+L + + Q N+ +K ++ + +Q +++EE ++ ++ L I+ +++
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 491 EEDDVDVRPARKSEAPFTHKV-NMKARFEQMAKARE--EEEQRRIEEQ--KLLRMQFEQR 545
++ V + + F ++ N+ ++E+ A A + E+ + R++++ L+ QR
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSV 593
++ + L+KK+ + ++ N S+ +E+ R+ A +K K S+
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1488
Score = 70.1 bits (170), Expect = 6e-12
Identities = 111/540 (20%), Positives = 227/540 (42%), Gaps = 60/540 (11%)
Query: 44 ERNQRRSRDEKQRRKEQYIR--------EREWNRRKQEIKEMLAS-DDEEDVSSKVEKAY 94
E ++R + E + +QY E+ NR +QE+ +++ D++ + S +EK
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450
Query: 95 --VPKLTGTVKGRFAEMEKQRQEEQRKRTEEERK-----RRIEQDMLEKRKIQRELAKRA 147
+L K ++ +R + + E+E K R +E+ + K +++R
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 148 EQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKE-RIKYEE 206
++ED+ S + G + + K+ ++ E+++ + EE E ++ E
Sbjct: 1511 AEMEDL----VSSKDDVGKNVHELE-------KSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
D ++R E +LK L DE E +++ L+ E E + ++ RK++A
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ------LQRQLHEYETELEDERKQRA 1613
Query: 267 -EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE 325
A+K+LE + + E + EE K R KL+ ++ +R+ ED
Sbjct: 1614 LAAAAKKKLEGDLKDLELQADSAIKGREE------AIKQLR--KLQAQMKDFQREL-EDA 1664
Query: 326 KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELL--K 383
+ +E E EKKA + M + +D + Q L +L L +
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 384 QKMEEEKRRTEE---ERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRS 440
+++EKRR E + + +LE E+ E + + + ++ E LS E + +RS
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ--LSNE----LATERS 1778
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEE-ERARRRAIDLEIKEREAENFHEEDDVDVRP 499
+ + ++ + + E+ KE++ K+ E E A + I EA+ E+ V+
Sbjct: 1779 TAQKNESARQQLER----QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 500 ARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE 559
K A + K K E + + +E + +++ + +++ L++ EE +
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 98.2 bits (243), Expect = 2e-20
Identities = 149/615 (24%), Positives = 262/615 (42%), Gaps = 98/615 (15%)
Query: 30 DVKDKFEAMQRAREERNQ-----RRSRDEKQRRKEQYIREREWNRRK--QEIKEMLASDD 82
D D Q R +R Q +++ DE+ R E ++E + +E+ E L
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
Query: 83 EEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQE-EQRKRTEEERKRRIEQDMLEKRKIQR 141
+ K + K + G + + +QE E +K+ E + + ++ + + +
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283
Query: 142 ELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKER 201
EL + ++++ + T +E + +K K + +D ++ +E+ R
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGKA-------IKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 202 IKYEEDKRIRY-EEQRPSLKEAKCLSLVMDDEIESEAKKE--------SLSPGKLKL--- 249
K ++R EE+R SL++ +D+E+E++ E LS K KL
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQ------LDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390
Query: 250 --TFEELERQRQ------ENRKKQAEEEARK--RLEEEK-RAFEEARRQMVNEDEENQDT 298
T E LE ++ EN +Q EE+A +LE+ K R +E +V+ D + Q
Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450
Query: 299 AKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSP 358
+ + K R L+ E+ + DE+ +AE EAR E+E KA + AR +
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKETKALSLARALEEALEAKE 1507
Query: 359 EMYKT-----ISQEFLTPGKLEI--NFEELLKQK------MEEEKRRTEE---------E 396
E+ +T E L K ++ N EL K K MEE K + EE +
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 397 RKHKLEMEKQ----EFEQLRQEMGEEEEENETFGLSR---EYEELIKLKRSGSIQAKNLK 449
K +LE+ Q +FE+ Q E+ EE L R EYE ++ +R A K
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETELEDERKQRALAAAAK 1626
Query: 450 SKFEKIGQLSEKEIQ-----KKIEEERARRRAIDLEIKE--REAENFHEEDDVDVRPARK 502
K E G L + E+Q K EE + R + ++K+ RE E+ D A++
Sbjct: 1627 KKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1684
Query: 503 SEAPFTH-KVNMKARFEQMAKAREEEEQRRIEEQKLLR-----------MQFEQREIDAA 550
+E + ++ E +A A +Q +E+++L +Q E+R ++A
Sbjct: 1685 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1744
Query: 551 LQKKREEEEEEEGSI 565
+ + EE EEE+G++
Sbjct: 1745 IAQLEEELEEEQGNM 1759
Score = 79.3 bits (194), Expect = 1e-14
Identities = 137/640 (21%), Positives = 261/640 (40%), Gaps = 122/640 (19%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRK-----EQYIREREWNRRKQEIK--------- 75
++ + EA E+R Q+ + K+ + E+ + E E R+K +++
Sbjct: 929 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 76 ----EMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQ------------EEQRK 119
E+L DD+ + SK K +++ E EK + E
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 120 RTEEERKRRIEQDMLEKRKIQRELAKRAEQIED----INNTGTESASEEGDDSLLITVVP 175
R ++E K R E + L KRK++ + + EQI D I + A +E + + +
Sbjct: 1049 RLKKEEKSRQELEKL-KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 176 VKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSL-KEAKCLSLVMDDEIE 234
+ + + +KK E + +E + E R + E+Q+ L +E + L ++D ++
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167
Query: 235 SEAKKESLSPGK------LKLTFEE----LERQRQENRKK--QAEEEARKRLEEEKRAFE 282
S A ++ L + LK +E E Q QE R+K QA EE ++LE+ KRA
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 283 EARRQMVNEDEENQD---------TAKIFKGYRPGKLKLSFEEMERQRREDEKRKAE-EE 332
+ ++EN D AK ++ KL+ +E++ + + E+ +AE +
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 333 ARRRIEEEKKAF------AEARRNMVVDD---------DSPEMYKTISQEFLTPGKLEIN 377
+++ E ++ AE + + D D+ E+ + +++ L
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 378 FEE---LLKQKMEEEKRRTEEERKH------KLEMEKQEFEQLRQ-----EMGEEEEENE 423
EE L+ +++EE + +H +L K++ + E G++ + E
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 424 TFGLSREYEELIKL-----KRSGSIQ----------------AKNLKSKFEKIGQL--SE 460
L+++YEE K +Q NL+ K K QL E
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 461 KEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQM 520
K I K +ER R A E +E+E + ++ K E T+K+ +KA E +
Sbjct: 1468 KNISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKM-LKAEMEDL 1523
Query: 521 AKAREE--------EEQRRIEEQKLLRMQFEQREIDAALQ 552
++++ E+ +R E ++ M+ + E++ LQ
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Score = 79.0 bits (193), Expect = 1e-14
Identities = 119/507 (23%), Positives = 213/507 (42%), Gaps = 75/507 (14%)
Query: 6 QKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREER--NQRRSRDEKQRRKEQYIR 63
+K + LL+ K + Y D +D+ EA R +E + + R+ +E KE+
Sbjct: 1458 RKFDQLLAEEKNISSKYA------DERDRAEAEAREKETKALSLARALEEALEAKEEL-- 1509
Query: 64 EREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQE-EQRKRTE 122
ER K E++++++S D DV V + + K ++ + EM+ Q +E E +
Sbjct: 1510 ERTNKMLKAEMEDLVSSKD--DVGKNVHE--LEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 123 EERKRRIEQDMLE-KRKIQRELAKRAEQIED----INNTGTESASEEGDDSLLITVVPVK 177
E+ K R+E +M K + +R+L R EQ E+ + E +E D+ +
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625
Query: 178 SYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIR-----YEEQRPSLKEAKCLSLVMDDE 232
K G +K DLE + + + + E K++R ++ + L++A+ DE
Sbjct: 1626 KKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR----DE 1677
Query: 233 I-----ESEAKKESLSPGKLKL-----TFEELERQRQENRKKQAEEEA-----RKRLEEE 277
I E+E K +SL ++L E +Q +++ AEE A R L++E
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 278 KRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQ-RREDEKRKAEEEARRR 336
KR E Q+ E EE Q + R K E++ + E + E AR++
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSD-RVRKATQQAEQLSNELATERSTAQKNESARQQ 1796
Query: 337 IEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--------- 387
+E + K M S + TI+ +LE E+ ++K
Sbjct: 1797 LERQNKELRSKLHEMEGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
Query: 388 ----------EEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG-----LSREYE 432
E++R+ E+ K + E +QL++++ E EEE++ L RE +
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915
Query: 433 ELIKLKRSGSIQAKNLKSKFEKIGQLS 459
E + + + LKSK + + S
Sbjct: 1916 EATESNEAMGREVNALKSKLRRGNETS 1942
Score = 74.3 bits (181), Expect = 3e-13
Identities = 126/648 (19%), Positives = 276/648 (42%), Gaps = 96/648 (14%)
Query: 38 MQRAREERNQRRSRDEKQRRKEQY------IREREWNR---------------------- 69
+Q R+E + DE Q+ KE+ ++E E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 70 -----------RKQEIKEMLAS-----DDEEDVSSKV--EKAYVPKLTGTVKGRFAEMEK 111
+KQE++E+L ++EED ++ E+ + + ++ + E E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 112 QRQEEQ-RKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLL 170
RQ+ Q K T E + +++E ++L +L+K + +E+ + T + +EE + +
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 171 ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYE-EDKRIRYEEQ----RPSLKEAKCL 225
+T + K +++ + EK R+E E++K + E + EQ + + E K
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 226 SLVMDDEIESEAKK---ESLSPGKLKLTFEELERQRQENRKK-QAEEEARKRLEEEKRAF 281
++E+++ + E ELE + ++ +E AR + E++KR
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 282 EEARRQMVNEDEENQDTAKIFKGYRPGK------LKLSFEEMER--QRREDEKRKAEEEA 333
E + E E+ D+ + R + LK + +E R + + E R+ +A
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKT-ISQEFLTPG-----------KLEINFEEL 381
+ E+ + F A+ N+ + + E ++ E G KLE +EL
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 382 LKQKMEEEKRRTE-EERKHKLEMEKQEFEQLRQEMGEEEEE-----NETFGLSREYEELI 435
+ + E+ R E ++ HKL+ E E + + E E + + LS + ++
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQ---NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 436 KLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAID-----LEIKEREAENFH 490
+L + + Q N+ +K ++ + +Q +++EE ++ ++ L I+ +++
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 491 EEDDVDVRPARKSEAPFTHKV-NMKARFEQMAKARE--EEEQRRIEEQ--KLLRMQFEQR 545
++ V + + F ++ N+ ++E+ A A + E+ + R++++ L+ QR
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSV 593
++ + L+KK+ + ++ N S+ +E+ R+ A +K K S+
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1495
Score = 70.1 bits (170), Expect = 6e-12
Identities = 111/540 (20%), Positives = 227/540 (42%), Gaps = 60/540 (11%)
Query: 44 ERNQRRSRDEKQRRKEQYIR--------EREWNRRKQEIKEMLAS-DDEEDVSSKVEKAY 94
E ++R + E + +QY E+ NR +QE+ +++ D++ + S +EK
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457
Query: 95 --VPKLTGTVKGRFAEMEKQRQEEQRKRTEEERK-----RRIEQDMLEKRKIQRELAKRA 147
+L K ++ +R + + E+E K R +E+ + K +++R
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 148 EQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKE-RIKYEE 206
++ED+ S + G + + K+ ++ E+++ + EE E ++ E
Sbjct: 1518 AEMEDL----VSSKDDVGKNVHELE-------KSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
D ++R E +LK L DE E +++ L+ E E + ++ RK++A
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ------LQRQLHEYETELEDERKQRA 1620
Query: 267 -EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE 325
A+K+LE + + E + EE K R KL+ ++ +R+ ED
Sbjct: 1621 LAAAAKKKLEGDLKDLELQADSAIKGREE------AIKQLR--KLQAQMKDFQREL-EDA 1671
Query: 326 KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELL--K 383
+ +E E EKKA + M + +D + Q L +L L +
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 384 QKMEEEKRRTEE---ERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRS 440
+++EKRR E + + +LE E+ E + + + ++ E LS E + +RS
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ--LSNE----LATERS 1785
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEE-ERARRRAIDLEIKEREAENFHEEDDVDVRP 499
+ + ++ + + E+ KE++ K+ E E A + I EA+ E+ V+
Sbjct: 1786 TAQKNESARQQLER----QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 500 ARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE 559
K A + K K E + + +E + +++ + +++ L++ EE +
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 98.2 bits (243), Expect = 2e-20
Identities = 149/615 (24%), Positives = 262/615 (42%), Gaps = 98/615 (15%)
Query: 30 DVKDKFEAMQRAREERNQ-----RRSRDEKQRRKEQYIREREWNRRK--QEIKEMLASDD 82
D D Q R +R Q +++ DE+ R E ++E + +E+ E L
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
Query: 83 EEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQE-EQRKRTEEERKRRIEQDMLEKRKIQR 141
+ K + K + G + + +QE E +K+ E + + ++ + + +
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283
Query: 142 ELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKER 201
EL + ++++ + T +E + +K K + +D ++ +E+ R
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGKA-------IKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 202 IKYEEDKRIRY-EEQRPSLKEAKCLSLVMDDEIESEAKKE--------SLSPGKLKL--- 249
K ++R EE+R SL++ +D+E+E++ E LS K KL
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQ------LDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390
Query: 250 --TFEELERQRQ------ENRKKQAEEEARK--RLEEEK-RAFEEARRQMVNEDEENQDT 298
T E LE ++ EN +Q EE+A +LE+ K R +E +V+ D + Q
Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450
Query: 299 AKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSP 358
+ + K R L+ E+ + DE+ +AE EAR E+E KA + AR +
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKETKALSLARALEEALEAKE 1507
Query: 359 EMYKT-----ISQEFLTPGKLEI--NFEELLKQK------MEEEKRRTEE---------E 396
E+ +T E L K ++ N EL K K MEE K + EE +
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 397 RKHKLEMEKQ----EFEQLRQEMGEEEEENETFGLSR---EYEELIKLKRSGSIQAKNLK 449
K +LE+ Q +FE+ Q E+ EE L R EYE ++ +R A K
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETELEDERKQRALAAAAK 1626
Query: 450 SKFEKIGQLSEKEIQ-----KKIEEERARRRAIDLEIKE--REAENFHEEDDVDVRPARK 502
K E G L + E+Q K EE + R + ++K+ RE E+ D A++
Sbjct: 1627 KKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1684
Query: 503 SEAPFTH-KVNMKARFEQMAKAREEEEQRRIEEQKLLR-----------MQFEQREIDAA 550
+E + ++ E +A A +Q +E+++L +Q E+R ++A
Sbjct: 1685 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1744
Query: 551 LQKKREEEEEEEGSI 565
+ + EE EEE+G++
Sbjct: 1745 IAQLEEELEEEQGNM 1759
Score = 79.3 bits (194), Expect = 1e-14
Identities = 137/640 (21%), Positives = 261/640 (40%), Gaps = 122/640 (19%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRK-----EQYIREREWNRRKQEIK--------- 75
++ + EA E+R Q+ + K+ + E+ + E E R+K +++
Sbjct: 929 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 76 ----EMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQ------------EEQRK 119
E+L DD+ + SK K +++ E EK + E
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 120 RTEEERKRRIEQDMLEKRKIQRELAKRAEQIED----INNTGTESASEEGDDSLLITVVP 175
R ++E K R E + L KRK++ + + EQI D I + A +E + + +
Sbjct: 1049 RLKKEEKSRQELEKL-KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 176 VKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSL-KEAKCLSLVMDDEIE 234
+ + + +KK E + +E + E R + E+Q+ L +E + L ++D ++
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167
Query: 235 SEAKKESLSPGK------LKLTFEE----LERQRQENRKK--QAEEEARKRLEEEKRAFE 282
S A ++ L + LK +E E Q QE R+K QA EE ++LE+ KRA
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 283 EARRQMVNEDEENQD---------TAKIFKGYRPGKLKLSFEEMERQRREDEKRKAE-EE 332
+ ++EN D AK ++ KL+ +E++ + + E+ +AE +
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 333 ARRRIEEEKKAF------AEARRNMVVDD---------DSPEMYKTISQEFLTPGKLEIN 377
+++ E ++ AE + + D D+ E+ + +++ L
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 378 FEE---LLKQKMEEEKRRTEEERKH------KLEMEKQEFEQLRQ-----EMGEEEEENE 423
EE L+ +++EE + +H +L K++ + E G++ + E
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 424 TFGLSREYEELIKL-----KRSGSIQ----------------AKNLKSKFEKIGQL--SE 460
L+++YEE K +Q NL+ K K QL E
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 461 KEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQM 520
K I K +ER R A E +E+E + ++ K E T+K+ +KA E +
Sbjct: 1468 KNISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKM-LKAEMEDL 1523
Query: 521 AKAREE--------EEQRRIEEQKLLRMQFEQREIDAALQ 552
++++ E+ +R E ++ M+ + E++ LQ
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Score = 77.8 bits (190), Expect = 3e-14
Identities = 118/499 (23%), Positives = 210/499 (42%), Gaps = 75/499 (15%)
Query: 6 QKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREER--NQRRSRDEKQRRKEQYIR 63
+K + LL+ K + Y D +D+ EA R +E + + R+ +E KE+
Sbjct: 1458 RKFDQLLAEEKNISSKYA------DERDRAEAEAREKETKALSLARALEEALEAKEEL-- 1509
Query: 64 EREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQE-EQRKRTE 122
ER K E++++++S D DV V + + K ++ + EM+ Q +E E +
Sbjct: 1510 ERTNKMLKAEMEDLVSSKD--DVGKNVHE--LEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 123 EERKRRIEQDMLE-KRKIQRELAKRAEQIED----INNTGTESASEEGDDSLLITVVPVK 177
E+ K R+E +M K + +R+L R EQ E+ + E +E D+ +
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625
Query: 178 SYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIR-----YEEQRPSLKEAKCLSLVMDDE 232
K G +K DLE + + + + E K++R ++ + L++A+ DE
Sbjct: 1626 KKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR----DE 1677
Query: 233 I-----ESEAKKESLSPGKLKL-----TFEELERQRQENRKKQAEEEA-----RKRLEEE 277
I E+E K +SL ++L E +Q +++ AEE A R L++E
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 278 KRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQ-RREDEKRKAEEEARRR 336
KR E Q+ E EE Q + R K E++ + E + E AR++
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSD-RVRKATQQAEQLSNELATERSTAQKNESARQQ 1796
Query: 337 IEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--------- 387
+E + K M S + TI+ +LE E+ ++K
Sbjct: 1797 LERQNKELRSKLHEMEGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
Query: 388 ----------EEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG-----LSREYE 432
E++R+ E+ K + E +QL++++ E EEE++ L RE +
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915
Query: 433 ELIKLKRSGSIQAKNLKSK 451
E + + + LKSK
Sbjct: 1916 EATESNEAMGREVNALKSK 1934
Score = 74.3 bits (181), Expect = 3e-13
Identities = 126/648 (19%), Positives = 276/648 (42%), Gaps = 96/648 (14%)
Query: 38 MQRAREERNQRRSRDEKQRRKEQY------IREREWNR---------------------- 69
+Q R+E + DE Q+ KE+ ++E E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 70 -----------RKQEIKEMLAS-----DDEEDVSSKV--EKAYVPKLTGTVKGRFAEMEK 111
+KQE++E+L ++EED ++ E+ + + ++ + E E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 112 QRQEEQ-RKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLL 170
RQ+ Q K T E + +++E ++L +L+K + +E+ + T + +EE + +
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 171 ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYE-EDKRIRYEEQ----RPSLKEAKCL 225
+T + K +++ + EK R+E E++K + E + EQ + + E K
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 226 SLVMDDEIESEAKK---ESLSPGKLKLTFEELERQRQENRKK-QAEEEARKRLEEEKRAF 281
++E+++ + E ELE + ++ +E AR + E++KR
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 282 EEARRQMVNEDEENQDTAKIFKGYRPGK------LKLSFEEMER--QRREDEKRKAEEEA 333
E + E E+ D+ + R + LK + +E R + + E R+ +A
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKT-ISQEFLTPG-----------KLEINFEEL 381
+ E+ + F A+ N+ + + E ++ E G KLE +EL
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 382 LKQKMEEEKRRTE-EERKHKLEMEKQEFEQLRQEMGEEEEE-----NETFGLSREYEELI 435
+ + E+ R E ++ HKL+ E E + + E E + + LS + ++
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQ---NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 436 KLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAID-----LEIKEREAENFH 490
+L + + Q N+ +K ++ + +Q +++EE ++ ++ L I+ +++
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 491 EEDDVDVRPARKSEAPFTHKV-NMKARFEQMAKARE--EEEQRRIEEQ--KLLRMQFEQR 545
++ V + + F ++ N+ ++E+ A A + E+ + R++++ L+ QR
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSV 593
++ + L+KK+ + ++ N S+ +E+ R+ A +K K S+
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1495
Score = 70.1 bits (170), Expect = 6e-12
Identities = 111/540 (20%), Positives = 227/540 (42%), Gaps = 60/540 (11%)
Query: 44 ERNQRRSRDEKQRRKEQYIR--------EREWNRRKQEIKEMLAS-DDEEDVSSKVEKAY 94
E ++R + E + +QY E+ NR +QE+ +++ D++ + S +EK
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457
Query: 95 --VPKLTGTVKGRFAEMEKQRQEEQRKRTEEERK-----RRIEQDMLEKRKIQRELAKRA 147
+L K ++ +R + + E+E K R +E+ + K +++R
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 148 EQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKE-RIKYEE 206
++ED+ S + G + + K+ ++ E+++ + EE E ++ E
Sbjct: 1518 AEMEDL----VSSKDDVGKNVHELE-------KSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
D ++R E +LK L DE E +++ L+ E E + ++ RK++A
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ------LQRQLHEYETELEDERKQRA 1620
Query: 267 -EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE 325
A+K+LE + + E + EE K R KL+ ++ +R+ ED
Sbjct: 1621 LAAAAKKKLEGDLKDLELQADSAIKGREE------AIKQLR--KLQAQMKDFQREL-EDA 1671
Query: 326 KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELL--K 383
+ +E E EKKA + M + +D + Q L +L L +
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 384 QKMEEEKRRTEE---ERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRS 440
+++EKRR E + + +LE E+ E + + + ++ E LS E + +RS
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ--LSNE----LATERS 1785
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEE-ERARRRAIDLEIKEREAENFHEEDDVDVRP 499
+ + ++ + + E+ KE++ K+ E E A + I EA+ E+ V+
Sbjct: 1786 TAQKNESARQQLER----QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 500 ARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE 559
K A + K K E + + +E + +++ + +++ L++ EE +
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 98.2 bits (243), Expect = 2e-20
Identities = 149/615 (24%), Positives = 262/615 (42%), Gaps = 98/615 (15%)
Query: 30 DVKDKFEAMQRAREERNQ-----RRSRDEKQRRKEQYIREREWNRRK--QEIKEMLASDD 82
D D Q R +R Q +++ DE+ R E ++E + +E+ E L
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 83 EEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQE-EQRKRTEEERKRRIEQDMLEKRKIQR 141
+ K + K + G + + +QE E +K+ E + + ++ + + +
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276
Query: 142 ELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKER 201
EL + ++++ + T +E + +K K + +D ++ +E+ R
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKA-------IKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 202 IKYEEDKRIRY-EEQRPSLKEAKCLSLVMDDEIESEAKKE--------SLSPGKLKL--- 249
K ++R EE+R SL++ +D+E+E++ E LS K KL
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQ------LDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Query: 250 --TFEELERQRQ------ENRKKQAEEEARK--RLEEEK-RAFEEARRQMVNEDEENQDT 298
T E LE ++ EN +Q EE+A +LE+ K R +E +V+ D + Q
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443
Query: 299 AKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSP 358
+ + K R L+ E+ + DE+ +AE EAR E+E KA + AR +
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKETKALSLARALEEALEAKE 1500
Query: 359 EMYKT-----ISQEFLTPGKLEI--NFEELLKQK------MEEEKRRTEE---------E 396
E+ +T E L K ++ N EL K K MEE K + EE +
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 397 RKHKLEMEKQ----EFEQLRQEMGEEEEENETFGLSR---EYEELIKLKRSGSIQAKNLK 449
K +LE+ Q +FE+ Q E+ EE L R EYE ++ +R A K
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETELEDERKQRALAAAAK 1619
Query: 450 SKFEKIGQLSEKEIQ-----KKIEEERARRRAIDLEIKE--REAENFHEEDDVDVRPARK 502
K E G L + E+Q K EE + R + ++K+ RE E+ D A++
Sbjct: 1620 KKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1677
Query: 503 SEAPFTH-KVNMKARFEQMAKAREEEEQRRIEEQKLLR-----------MQFEQREIDAA 550
+E + ++ E +A A +Q +E+++L +Q E+R ++A
Sbjct: 1678 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1737
Query: 551 LQKKREEEEEEEGSI 565
+ + EE EEE+G++
Sbjct: 1738 IAQLEEELEEEQGNM 1752
Score = 79.3 bits (194), Expect = 1e-14
Identities = 137/640 (21%), Positives = 261/640 (40%), Gaps = 122/640 (19%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRK-----EQYIREREWNRRKQEIK--------- 75
++ + EA E+R Q+ + K+ + E+ + E E R+K +++
Sbjct: 922 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 76 ----EMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQ------------EEQRK 119
E+L DD+ + SK K +++ E EK + E
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 120 RTEEERKRRIEQDMLEKRKIQRELAKRAEQIED----INNTGTESASEEGDDSLLITVVP 175
R ++E K R E + L KRK++ + + EQI D I + A +E + + +
Sbjct: 1042 RLKKEEKSRQELEKL-KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 176 VKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSL-KEAKCLSLVMDDEIE 234
+ + + +KK E + +E + E R + E+Q+ L +E + L ++D ++
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160
Query: 235 SEAKKESLSPGK------LKLTFEE----LERQRQENRKK--QAEEEARKRLEEEKRAFE 282
S A ++ L + LK +E E Q QE R+K QA EE ++LE+ KRA
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 283 EARRQMVNEDEENQD---------TAKIFKGYRPGKLKLSFEEMERQRREDEKRKAE-EE 332
+ ++EN D AK ++ KL+ +E++ + + E+ +AE +
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 333 ARRRIEEEKKAF------AEARRNMVVDD---------DSPEMYKTISQEFLTPGKLEIN 377
+++ E ++ AE + + D D+ E+ + +++ L
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 378 FEE---LLKQKMEEEKRRTEEERKH------KLEMEKQEFEQLRQ-----EMGEEEEENE 423
EE L+ +++EE + +H +L K++ + E G++ + E
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 424 TFGLSREYEELIKL-----KRSGSIQ----------------AKNLKSKFEKIGQL--SE 460
L+++YEE K +Q NL+ K K QL E
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 461 KEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQM 520
K I K +ER R A E +E+E + ++ K E T+K+ +KA E +
Sbjct: 1461 KNISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKM-LKAEMEDL 1516
Query: 521 AKAREE--------EEQRRIEEQKLLRMQFEQREIDAALQ 552
++++ E+ +R E ++ M+ + E++ LQ
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Score = 77.8 bits (190), Expect = 3e-14
Identities = 118/499 (23%), Positives = 210/499 (42%), Gaps = 75/499 (15%)
Query: 6 QKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREER--NQRRSRDEKQRRKEQYIR 63
+K + LL+ K + Y D +D+ EA R +E + + R+ +E KE+
Sbjct: 1451 RKFDQLLAEEKNISSKYA------DERDRAEAEAREKETKALSLARALEEALEAKEEL-- 1502
Query: 64 EREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQE-EQRKRTE 122
ER K E++++++S D DV V + + K ++ + EM+ Q +E E +
Sbjct: 1503 ERTNKMLKAEMEDLVSSKD--DVGKNVHE--LEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 123 EERKRRIEQDMLE-KRKIQRELAKRAEQIED----INNTGTESASEEGDDSLLITVVPVK 177
E+ K R+E +M K + +R+L R EQ E+ + E +E D+ +
Sbjct: 1559 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618
Query: 178 SYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIR-----YEEQRPSLKEAKCLSLVMDDE 232
K G +K DLE + + + + E K++R ++ + L++A+ DE
Sbjct: 1619 KKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR----DE 1670
Query: 233 I-----ESEAKKESLSPGKLKL-----TFEELERQRQENRKKQAEEEA-----RKRLEEE 277
I E+E K +SL ++L E +Q +++ AEE A R L++E
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 278 KRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQ-RREDEKRKAEEEARRR 336
KR E Q+ E EE Q + R K E++ + E + E AR++
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSD-RVRKATQQAEQLSNELATERSTAQKNESARQQ 1789
Query: 337 IEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME--------- 387
+E + K M S + TI+ +LE E+ ++K
Sbjct: 1790 LERQNKELRSKLHEMEGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 388 ----------EEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG-----LSREYE 432
E++R+ E+ K + E +QL++++ E EEE++ L RE +
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908
Query: 433 ELIKLKRSGSIQAKNLKSK 451
E + + + LKSK
Sbjct: 1909 EATESNEAMGREVNALKSK 1927
Score = 74.3 bits (181), Expect = 3e-13
Identities = 126/648 (19%), Positives = 276/648 (42%), Gaps = 96/648 (14%)
Query: 38 MQRAREERNQRRSRDEKQRRKEQY------IREREWNR---------------------- 69
+Q R+E + DE Q+ KE+ ++E E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 70 -----------RKQEIKEMLAS-----DDEEDVSSKV--EKAYVPKLTGTVKGRFAEMEK 111
+KQE++E+L ++EED ++ E+ + + ++ + E E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 112 QRQEEQ-RKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLL 170
RQ+ Q K T E + +++E ++L +L+K + +E+ + T + +EE + +
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 171 ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYE-EDKRIRYEEQ----RPSLKEAKCL 225
+T + K +++ + EK R+E E++K + E + EQ + + E K
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 226 SLVMDDEIESEAKK---ESLSPGKLKLTFEELERQRQENRKK-QAEEEARKRLEEEKRAF 281
++E+++ + E ELE + ++ +E AR + E++KR
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 282 EEARRQMVNEDEENQDTAKIFKGYRPGK------LKLSFEEMER--QRREDEKRKAEEEA 333
E + E E+ D+ + R + LK + +E R + + E R+ +A
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 334 RRRIEEEKKAFAEARRNMVVDDDSPEMYKT-ISQEFLTPG-----------KLEINFEEL 381
+ E+ + F A+ N+ + + E ++ E G KLE +EL
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 382 LKQKMEEEKRRTE-EERKHKLEMEKQEFEQLRQEMGEEEEE-----NETFGLSREYEELI 435
+ + E+ R E ++ HKL+ E E + + E E + + LS + ++
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQ---NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 436 KLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAID-----LEIKEREAENFH 490
+L + + Q N+ +K ++ + +Q +++EE ++ ++ L I+ +++
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 491 EEDDVDVRPARKSEAPFTHKV-NMKARFEQMAKARE--EEEQRRIEEQ--KLLRMQFEQR 545
++ V + + F ++ N+ ++E+ A A + E+ + R++++ L+ QR
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSV 593
++ + L+KK+ + ++ N S+ +E+ R+ A +K K S+
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1488
Score = 70.1 bits (170), Expect = 6e-12
Identities = 111/540 (20%), Positives = 227/540 (42%), Gaps = 60/540 (11%)
Query: 44 ERNQRRSRDEKQRRKEQYIR--------EREWNRRKQEIKEMLAS-DDEEDVSSKVEKAY 94
E ++R + E + +QY E+ NR +QE+ +++ D++ + S +EK
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450
Query: 95 --VPKLTGTVKGRFAEMEKQRQEEQRKRTEEERK-----RRIEQDMLEKRKIQRELAKRA 147
+L K ++ +R + + E+E K R +E+ + K +++R
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 148 EQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKE-RIKYEE 206
++ED+ S + G + + K+ ++ E+++ + EE E ++ E
Sbjct: 1511 AEMEDL----VSSKDDVGKNVHELE-------KSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
D ++R E +LK L DE E +++ L+ E E + ++ RK++A
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ------LQRQLHEYETELEDERKQRA 1613
Query: 267 -EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE 325
A+K+LE + + E + EE K R KL+ ++ +R+ ED
Sbjct: 1614 LAAAAKKKLEGDLKDLELQADSAIKGREE------AIKQLR--KLQAQMKDFQREL-EDA 1664
Query: 326 KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELL--K 383
+ +E E EKKA + M + +D + Q L +L L +
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 384 QKMEEEKRRTEE---ERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRS 440
+++EKRR E + + +LE E+ E + + + ++ E LS E + +RS
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ--LSNE----LATERS 1778
Query: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEE-ERARRRAIDLEIKEREAENFHEEDDVDVRP 499
+ + ++ + + E+ KE++ K+ E E A + I EA+ E+ V+
Sbjct: 1779 TAQKNESARQQLER----QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 500 ARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEE 559
K A + K K E + + +E + +++ + +++ L++ EE +
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 96.7 bits (239), Expect = 6e-20
Identities = 102/451 (22%), Positives = 198/451 (43%), Gaps = 51/451 (11%)
Query: 36 EAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYV 95
+A + A + +R + E++RR+E+ ERE +R+++ + E+D K
Sbjct: 44 QAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRR-------EKDRHRK------ 90
Query: 96 PKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
+ R E ++ R++E+ ++T+ ER R+ E++ +++ +RE + E+ D
Sbjct: 91 -------RDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQT 143
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKERE-----EKERIKYEEDKRI 210
G + D + K ++ D E++R+ +KER + E++++
Sbjct: 144 DGQRERERQRD---------------AEKERERQTDRERQRQTERNRQKER-EREKNRQE 187
Query: 211 RYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLK-LTFEELERQR--QENRKKQAE 267
R E +R KE K + E E ++E+ + + K T E +RQR + R+KQAE
Sbjct: 188 RRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAE 247
Query: 268 EEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKR 327
E E E+ E R + + Q + + + E ER+R +R
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRER 307
Query: 328 KAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKME 387
+ E E R+ E E++ E R + D + +E + E++ E +Q
Sbjct: 308 ERERERNRKRERERERERERERQRETERDREK-----ERERKRKRQTEMD-RERNRQTGR 361
Query: 388 EEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKN 447
E +R+ E ER+ + E ++Q + R+E + + + R+ E+ +R Q +
Sbjct: 362 EGRRQAERERERERERDRQSARE-REERERDRDRDRQKERERQTEKDRDGQRETEKQRER 420
Query: 448 LKSKFEKIGQLSEKEIQKKIEEERARRRAID 478
K + + G+ +E +K+ ER R R D
Sbjct: 421 EKDRESERGRERGREREKQKGRERDRERQTD 451
Score = 94.0 bits (232), Expect = 4e-19
Identities = 94/427 (22%), Positives = 179/427 (41%), Gaps = 48/427 (11%)
Query: 36 EAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYV 95
E + + +R++ R RD ++ R+ Q RER+ R K+ ++ + E +
Sbjct: 84 EKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQT 143
Query: 96 PKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
+ R AE E++RQ ++ ++ + ER R+ E++ + R+ +RE ++ E+
Sbjct: 144 DGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREK------ 197
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQ 215
E+ +E+ + G+ ++ + E E E K + E D++ + E +
Sbjct: 198 ---ENKTED-------------RHSERGRERERERETETETERKRQTDRERDRQRKTERE 241
Query: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQ---------- 265
R E + S + E E + ++E + ER+RQ +RK+Q
Sbjct: 242 REKQAERERAS---ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETE 298
Query: 266 --AEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRRE 323
E + + E E+ E R+ E E ++T + + R K K EM+R+R
Sbjct: 299 RKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQ-TEMDRERNR 357
Query: 324 DEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLK 383
R+ +A R E E++ ++ R + + + +E T K E K
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTE-KDRDGQRETEK 416
Query: 384 QKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELI-----KLK 438
Q+ E+ R +E R+ E EKQ+ +E E + + G R+ L +
Sbjct: 417 QREREKDRESERGRERGREREKQK----GRERDRERQTDRQAGRQRKRSTLYVNPPPRTA 472
Query: 439 RSGSIQA 445
RSG +Q+
Sbjct: 473 RSGVVQS 479
Score = 89.7 bits (221), Expect = 8e-18
Identities = 96/480 (20%), Positives = 194/480 (40%), Gaps = 89/480 (18%)
Query: 107 AEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGD 166
A + + +R R +E +RR EKR+ +RE ++ E+ + +
Sbjct: 45 AHKDADGDDRERNRQKERERRR------EKRQTERETDRKRERRREKDR----------- 87
Query: 167 DSLLITVVPVKSYKTSGKMKKNFEDLEKERE---EKERIKYEEDKRIRYEEQRPSLKEAK 223
++ + ++ D EKERE ++ER + E +R R +E+
Sbjct: 88 ------------HRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERE------- 128
Query: 224 CLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEE 283
+ E E E ++ + G QR+ R++ AE+E ++ + E++ E
Sbjct: 129 -----RETEREGERGRDRQTDG-----------QRERERQRDAEKERERQTDRERQRQTE 172
Query: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEE---EARRRIEEE 340
RQ E E+N+ E ER+R+ +++ K E+ E R E E
Sbjct: 173 RNRQKEREREKNRQ-----------------ERRERERQREKENKTEDRHSERGRERERE 215
Query: 341 KKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHK 400
++ E R D + KT + + + E + K E +R + +R +
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275
Query: 401 LEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSE 460
+ +++ ++ RQ E + E E R+ E + +R K + + + + +
Sbjct: 276 QKERERQTDRKRQRRTERDRETE-----RKRERQRERERERERNRKRERERERERERERQ 330
Query: 461 KEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQM 520
+E ++ E+ER R+R +R+ E E + R R+ + + R Q
Sbjct: 331 RETERDREKERERKR-------KRQTEMDRERNRQTGREGRRQAE--RERERERERDRQS 381
Query: 521 AKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSG 580
A+ REE E+ R +++ R + +++ D + +++ E E++ G E + + G
Sbjct: 382 AREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKG 441
Score = 86.3 bits (212), Expect = 9e-17
Identities = 114/550 (20%), Positives = 212/550 (38%), Gaps = 104/550 (18%)
Query: 49 RSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAE 108
R R Q K+ +RE NR+K+ + E + K
Sbjct: 38 RRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRK------------------- 78
Query: 109 MEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDS 168
E++R++++ ++ + R+R+ +++ +R+ RE ++ E+ + EG+
Sbjct: 79 RERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERG 138
Query: 169 LLITVVPVKSYKTSGKMKKNFE-DLEKERE---EKERIKYEEDKRIRYEEQRPSLKEAKC 224
+ +T G+ ++ + D EKERE ++ER + E R + E+ + +E +
Sbjct: 139 --------RDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERR- 189
Query: 225 LSLVMDDEIESEAKKESLSPGKLKLTFEELERQR----QENRKKQAEEEARKRLEEEKRA 280
E E + +KE+ + + E ER+R + RK+Q + E ++ + E+
Sbjct: 190 -------ERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERER 242
Query: 281 FEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEE 340
++A R+ +E E +D +E ER+R D R RR+ E E
Sbjct: 243 EKQAERERASERETERD-----------------KERERERDRDRDRD-----RRQKERE 280
Query: 341 KKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHK 400
++ + +R D ++ E +++ E +R E RK +
Sbjct: 281 RQTDRKRQRRTERDRET----------------------ERKRERQRERERERERNRKRE 318
Query: 401 LEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSE 460
E E++ E E + ET RE E K KR Q + + + + G+
Sbjct: 319 RERERER---------ERERQRET-ERDREKERERKRKR----QTEMDRERNRQTGREGR 364
Query: 461 KEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQM 520
++ +++ E ER R R E +ERE + + R K + R +
Sbjct: 365 RQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDR 424
Query: 521 AKAREEEEQRRIEEQK-LLRMQFEQREIDAALQKKREE--EEEEEGSIMNGSTAEDEEQT 577
R E R E+QK R + Q + A Q+KR + +G D +
Sbjct: 425 ESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRP 484
Query: 578 RSGAPWFKKP 587
G W P
Sbjct: 485 TRGIRWKSSP 494
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 96.3 bits (238), Expect = 8e-20
Identities = 131/610 (21%), Positives = 269/610 (44%), Gaps = 109/610 (17%)
Query: 31 VKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRER-------------EWNRRKQEIKEM 77
+K+K EAM EER + R+EKQR++ + R + E + E+K
Sbjct: 1021 LKNKHEAMITDLEERLR---REEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ 1077
Query: 78 LASDDEEDVSS-------KVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRR-- 128
LA +EE ++ +K K ++ + +E+++ + E+ R + E+++R
Sbjct: 1078 LAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL 1137
Query: 129 ---IE------QDMLEKRKIQREL-AKRAEQIEDINNTGTESAS-------------EEG 165
+E +D L+ Q+EL +KR +++ + T E A +
Sbjct: 1138 GEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQA 1197
Query: 166 DDSLLITVVPVKSYKTS-GKMKKNFE------------------DLEKEREEKE------ 200
+ L + K K + K K+ E D E +R++ E
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257
Query: 201 RIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQ--- 257
++K+ E +R+R E K L + +D+ ++ +S S KL F LE Q
Sbjct: 1258 QVKFNEGERVRTELADKVTK----LQVELDNVTGLLSQSDSKS-SKLTKDFSALESQLQD 1312
Query: 258 -----RQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKL 312
++ENR+K + K++E+EK +F R Q+ E+E + K + L
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSF---REQLEEEEEAKHNLEK-----QIATLHA 1364
Query: 313 SFEEMERQRREDEK-RKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTP 371
+M+++ + + EE +R+++++ + ++ V D E KT Q+ L
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424
Query: 372 GKLEINFEELLKQKMEEEKRRTEE-ERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSRE 430
++++ + +E+++++ ++ + K K E+ R E E+E + L+R
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484
Query: 431 YEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFH 490
EE ++ K K +++ E + S+ ++ K + E +RA++ +++E + +
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDL-MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEE 1543
Query: 491 EEDDVDVRPARKSEAPFTHKVN---MKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREI 547
ED++ +A +VN MKA+FE+ + R+E+ E+K ++ + RE+
Sbjct: 1544 LEDELQA----TEDAKLRLEVNLQAMKAQFERDLQGRDEQ-----SEEKKKQLVRQVREM 1594
Query: 548 DAALQKKREE 557
+A L+ +R++
Sbjct: 1595 EAELEDERKQ 1604
Score = 96.3 bits (238), Expect = 8e-20
Identities = 139/612 (22%), Positives = 275/612 (44%), Gaps = 94/612 (15%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSK 89
D D A Q R +R Q + +K +E E + +Q+ + + E+ +K
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 90 VEKAYVPKLTGTVKGRFAEMEKQ-RQEEQRKRTEEERKRRIEQDMLEKR-------KIQR 141
KA + K T++ E+ + + Q K E +++++E + E + +++
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT 1269
Query: 142 ELAKRAE--QIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEK 199
ELA + Q+E N TG S S+ L ++S +++ E L++E +K
Sbjct: 1270 ELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES-----QLQDTQELLQEENRQK 1324
Query: 200 ----ERIKYEEDKRIRYEEQRPSLKEAKC----LSLVMDDEIESEAKKESLSPGKLKLTF 251
++K ED++ + EQ +EAK + ++ KK S G L+ T
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE-TA 1383
Query: 252 EELERQRQENRK--KQAEEE---ARKRLEEEK-RAFEEARRQMVNEDEENQDTAKIFKGY 305
EE++R+ Q++ + Q EE A +LE+ K R +E +V+ D + Q + K
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443
Query: 306 RPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTIS 365
+ L+ E+ + +E+ +AE EAR E+E KA + AR + E+ + ++
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAR---EKETKALSLARALEEAMEQKAELER-LN 1499
Query: 366 QEFLTPGKLEINFEELLKQKMEEEKRRTE-EERKHKLEMEKQEFEQLRQEMGEEEEENET 424
++F T E+L+ K + K E E+ K LE + +E + +E+ +E + E
Sbjct: 1500 KQFRT------EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553
Query: 425 FGLSREYE-ELIKLKRSGSIQAKNLKSKFEKIGQLSE--KEIQKKIEEER-------ARR 474
L E + +K + +Q ++ +S+ EK QL +E++ ++E+ER A R
Sbjct: 1554 AKLRLEVNLQAMKAQFERDLQGRDEQSE-EKKKQLVRQVREMEAELEDERKQRSMAVAAR 1612
Query: 475 RAIDLEIKEREA--ENFHEEDDVDVRPARKSEAPFTHKVN-----MKARFEQMAKAREEE 527
+ +++++K+ EA ++ ++ D ++ RK +A + +R E +A+A+E E
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENE 1672
Query: 528 EQRRIEEQKLLRMQFE-----------------------------------QREIDAALQ 552
++ + E +++++Q E +R ++A +
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIA 1732
Query: 553 KKREEEEEEEGS 564
+ EE EEE+G+
Sbjct: 1733 QLEEELEEEQGN 1744
Score = 87.0 bits (214), Expect = 5e-17
Identities = 157/681 (23%), Positives = 278/681 (40%), Gaps = 134/681 (19%)
Query: 38 MQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPK 97
MQ+ +E ++ +E R+K Q + + K+ +E + +D+ +K +K +
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000
Query: 98 LTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTG 157
+ E EK + + K E +E+ + + K ++EL K ++E +
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060
Query: 158 TESASE-------------EGDDSLLITVVPVKSYKTSGKMK-KNFEDLEKEREE-KERI 202
++ +E + ++ L + V+ M K +LE + E +E +
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120
Query: 203 KYEEDKRIRYEEQRPSL-KEAKCLSLVMDDEIESEAKKESLSPGK------LKLTFEE-- 253
+ E R + E+Q+ L +E + L ++D ++S A ++ L + LK T EE
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180
Query: 254 --LERQRQENRKK--QAEEEARKRLEEEKRA---FEEARRQMVNEDEENQDTAKIF---K 303
E Q QE R+K QA EE ++LE+ KR E+A++ + NE E + K+ K
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK 1240
Query: 304 GYRPGK----------LKLSFEEMERQRRE--DEKRKAEEE------------------- 332
G K L++ F E ER R E D+ K + E
Sbjct: 1241 GDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLT 1300
Query: 333 -----ARRRIEEEKKAFAEARRNMV--------VDDDSPEMYKTISQEFLTPGKLEINFE 379
++++ ++ E R + V+D+ + + +E LE
Sbjct: 1301 KDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIA 1360
Query: 380 EL------LKQKMEEEK--RRTEEERKHKLEMEKQEFEQLRQE--MGEEEEENETFGLSR 429
L +K+KME+ T EE K KL+ + + Q +E ++ E L +
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420
Query: 430 EYEELIKLKRSGSIQAKNLKSKFEKIGQL--SEKEIQKKIEEERAR---------RRAID 478
E ++L+ A NL+ K +K QL EK I K EER R +A+
Sbjct: 1421 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480
Query: 479 L-----EIKEREAE------NFHEE--------DDV--DVRPARKSEAPFTHKV-NMKAR 516
L E E++AE F E DDV V KS+ +V MK +
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540
Query: 517 FEQMAKAREEEEQRRIEEQKL---LRMQFEQREIDAALQKKREEEEEEEGSIMN-----G 568
E++ E+E + E+ KL + +Q + + + LQ + E+ EE++ ++
Sbjct: 1541 LEEL-----EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME 1595
Query: 569 STAEDEEQTRSGAPWFKKPLK 589
+ EDE + RS A +K L+
Sbjct: 1596 AELEDERKQRSMAVAARKKLE 1616
Score = 83.6 bits (205), Expect = 6e-16
Identities = 127/654 (19%), Positives = 270/654 (41%), Gaps = 124/654 (18%)
Query: 55 QRRKEQYIREREWN--RRKQEIKEML--ASDDEEDVSSKVEKAYVPKLTGTVKGRFAEME 110
QR Y++ R W R ++K +L + +EE ++ + E V + + R EME
Sbjct: 813 QRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEME 872
Query: 111 KQRQEEQRKRTEEERKRRIEQDML-EKRKIQRELAKRAEQIEDINNTGTESASEEGDDSL 169
+ + ++ + + + + E ++ E +++ L + +++E+I + E+ EE ++
Sbjct: 873 TLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHD-LEARVEEEEERC 931
Query: 170 LITVVPVKSYKTSGKMKKNFEDLEKEREEKE---------------RIKYEEDKRIRYEE 214
K KM++N ++LE++ EE+E ++K E+++I E+
Sbjct: 932 QHLQAEKK------KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILED 985
Query: 215 QRPSLKEAKCLSLVMDDEIE------SEAKKESLSPGKLKLTFEEL-----ERQRQENRK 263
Q L + K L ++D I +E +++S S KLK E + ER R+E ++
Sbjct: 986 QNCKLAKEKKL---LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 264 KQAEEEARKRLE-----------EEKRAFEEARRQMVNEDEENQDT-AKIFKGYRPGKLK 311
+Q E+ R++LE E + E + Q+ ++EE Q A++ + +
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA 1102
Query: 312 LS-FEEMERQRRE-DEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL 369
L E+E Q E E ++E +R + E++K+ E + + + QE
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR 1162
Query: 370 TPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEE--------- 420
+ + E+N +LK+ +EEE + E + + + Q E+L +++ + +
Sbjct: 1163 SKREQEVN---ILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219
Query: 421 ---ENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKI---------------------- 455
ENE L+ E + L++ K + K ++++ +++
Sbjct: 1220 QTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ 1279
Query: 456 -------GQLSE-------------------KEIQKKIEEERARRRAIDLEIKERE---- 485
G LS+ ++ Q+ ++EE ++ ++ ++K+ E
Sbjct: 1280 VELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKN 1339
Query: 486 --AENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFE 543
E EE++ ++ +MK + E E E+ + + QK L +
Sbjct: 1340 SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ 1399
Query: 544 QREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSE 597
+ E A K E+ + ++ + + Q +S KK K ++ E
Sbjct: 1400 RHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453
Score = 75.5 bits (184), Expect = 2e-13
Identities = 121/568 (21%), Positives = 249/568 (43%), Gaps = 99/568 (17%)
Query: 38 MQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDD---EEDVSSKVEK-A 93
+Q +R+E +E + +E+ + + ++ L ++ +E + ++ E A
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 94 YVPKLTGTVKGRFAEMEKQRQE-EQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIED 152
+L + + E+E+ + E R EEER + ++ EK+K+Q+ + + EQ+E+
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQA---EKKKMQQNIQELEEQLEE 954
Query: 153 INNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRY 212
ESA ++ + ++ T K+KK E+++I
Sbjct: 955 -----EESARQK---------LQLEKVTTEAKLKK-----------------LEEEQIIL 983
Query: 213 EEQRPSLKEAKCLSLVMDDEIE------SEAKKESLSPGKLKLTFEEL-----ERQRQEN 261
E+Q L + K L ++D I +E +++S S KLK E + ER R+E
Sbjct: 984 EDQNCKLAKEKKL---LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREE 1040
Query: 262 RKKQAEEEARKRLE-----------EEKRAFEEARRQMVNEDEENQDT-AKIFKGYRPGK 309
+++Q E+ R++LE E + E + Q+ ++EE Q A++ +
Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKN 1100
Query: 310 LKL-SFEEMERQRRE-DEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQE 367
+ L E+E Q E E ++E +R + E++K+ E + + + QE
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 368 FLTPGKLEINFEELLKQKMEEEKRRTEEE-----RKHKLEMEK--QEFEQLRQ-----EM 415
+ + E+N +LK+ +EEE + E + +KH +E+ ++ EQ ++ E
Sbjct: 1161 LRSKREQEVN---ILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEK 1217
Query: 416 GEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEE-ERARR 474
++ ENE L+ E + L++ K + K ++++ + E+Q K E ER R
Sbjct: 1218 AKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ--------ELQVKFNEGERVR- 1268
Query: 475 RAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEE 534
E+ ++ + E D+V ++ + A Q+ ++ +E + E
Sbjct: 1269 ----TELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQL---QDTQELLQEEN 1321
Query: 535 QKLLRMQFEQREIDAALQKKREEEEEEE 562
++ L + + ++++ RE+ EEEE
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEEEE 1349
Score = 72.8 bits (177), Expect = 1e-12
Identities = 109/506 (21%), Positives = 214/506 (42%), Gaps = 83/506 (16%)
Query: 6 QKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRER 65
+K + LL+ K + Y + +D+ EA R +E + +R ++ +++ ER
Sbjct: 1444 KKFDQLLAEEKTISAKYAEE------RDRAEAEAREKETKALSLARALEEAMEQKAELER 1497
Query: 66 EWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQE-EQRKRTEEE 124
+ + E++++++S D DV V + + K ++ + EM+ Q +E E + E+
Sbjct: 1498 LNKQFRTEMEDLMSSKD--DVGKSVHE--LEKSKRALEQQVEEMKTQLEELEDELQATED 1553
Query: 125 RKRRIEQDMLE-KRKIQRELAKRAEQIEDINNTGTESASE---EGDDSLLITVVPVKSYK 180
K R+E ++ K + +R+L R EQ E+ E E +D + V + K
Sbjct: 1554 AKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1613
Query: 181 TSGKMKKNFEDLEKEREEKERIKYEEDKRIR------------YEEQRPSLKEAKCLSLV 228
K++ + +DLE + + + E K++R ++ R S +E +
Sbjct: 1614 ---KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE------I 1664
Query: 229 MDDEIESEAKKESLSPGKLKL-----TFEELERQRQENRKKQAEEEARKRLE-----EEK 278
+ E+E K +S+ ++L E +RQ Q+ R + A+E A + EEK
Sbjct: 1665 LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEK 1724
Query: 279 RAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRR-EDEKRKAEEEARRRI 337
R E Q+ E EE Q ++ R K L +++ E + E AR+++
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELIND-RLKKANLQIDQINTDLNLERSHAQKNENARQQL 1783
Query: 338 EEEKKAFAEARRNMV------------------------VDDDSPEMYKTISQEFLTPGK 373
E + K + M +D+++ E Q T K
Sbjct: 1784 ERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKK 1843
Query: 374 LEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFG-----LS 428
L+ ++L Q +++RR E+ K + + +QL++++ E EEE + L
Sbjct: 1844 LK----DVLLQV--DDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Query: 429 REYEELIKLKRSGSIQAKNLKSKFEK 454
RE E+ + + + + +LK+K +
Sbjct: 1898 RELEDATETADAMNREVSSLKNKLRR 1923
Score = 49.7 bits (117), Expect = 9e-06
Identities = 76/334 (22%), Positives = 152/334 (45%), Gaps = 50/334 (14%)
Query: 278 KRAFEEARRQMVNEDEENQDTAKIFK--GYRPGKLKLSFEEMERQRREDEKRKAEEEARR 335
++AF + ++Q+ ++ A K ++ +L + + + R++E+ A+EE
Sbjct: 796 RKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELV 855
Query: 336 RIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEI--NFEELL------KQKME 387
++ E++ A AE R + S M + + + + E+ EEL KQ++E
Sbjct: 856 KVREKQLA-AENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELE 914
Query: 388 E------EKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENET-------------FGLS 428
E + EEER L+ EK++ +Q QE+ E+ EE E+ L
Sbjct: 915 EICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLK 974
Query: 429 REYEELIKLKRSGSIQAKNLKSKFEKIGQLS-----EKEIQKKIEEERARRRAIDLEIKE 483
+ EE I L+ AK K ++I + + E+E K + + + + A+ +++E
Sbjct: 975 KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE 1034
Query: 484 REAENFHEEDDVDVRPARKSEAPFTHKVNMKARFE------QMAKAREEEEQR----RIE 533
R + +++ + RK E T + A + +M A++EEE + R+E
Sbjct: 1035 RLRREEKQRQELE-KTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVE 1093
Query: 534 E---QKLLRMQFEQREIDAALQKKREEEEEEEGS 564
E QK + ++ + RE+++ + + +E+ E E S
Sbjct: 1094 EEAAQKNMALK-KIRELESQISELQEDLESERAS 1126
Score = 45.4 bits (106), Expect = 2e-04
Identities = 72/329 (21%), Positives = 141/329 (42%), Gaps = 41/329 (12%)
Query: 32 KDKFEAMQRAREERNQR----RSRDEKQRRKEQYIREREWNRRKQ--------EIKEMLA 79
K++ EA+++ R+ + Q R D+ + +E+ + + + N +K +++E LA
Sbjct: 1631 KNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELA 1690
Query: 80 SDDEEDVSSKVEKAYVPK--LTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR 137
+ + ++ E+ + + KG A EK+R E + + EEE +E++
Sbjct: 1691 AAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE----LEEEQGNTE 1746
Query: 138 KIQRELAKRAEQIEDIN------------NTGTESASEEGDDSLLITVVPVKSYKTSGKM 185
I L K QI+ IN N E + L + + ++ S K
Sbjct: 1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS-KY 1805
Query: 186 KKNFEDLE-KEREEKERIKYE-EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLS 243
K + LE K + +E++ E ++++ ++ R + K+ K + L +DDE A++
Sbjct: 1806 KASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE-RRNAEQYKDQ 1864
Query: 244 PGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFK 303
K ++L+RQ +E AEEEA++ ++ E D N++ + +
Sbjct: 1865 ADKASTRLKQLKRQLEE-----AEEEAQRANASRRKLQRELEDATETADAMNREVSSLKN 1919
Query: 304 GYRPGKLKLSFEEMERQRREDEKRKAEEE 332
R G L F R R+ ++EE
Sbjct: 1920 KLRRG--DLPFVVPRRMARKGAGDGSDEE 1946
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 95.1 bits (235), Expect = 2e-19
Identities = 121/560 (21%), Positives = 240/560 (42%), Gaps = 86/560 (15%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSK 89
D K K+E ++ E +S++++ + +E+ E E +R +E KE ++++ + +
Sbjct: 1513 DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE-KEQQVTEEQRHIQEE 1571
Query: 90 VEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDML--EKRKIQRELAKRA 147
++A + ++R ++KR +EERK E++ L E+R++ +E K A
Sbjct: 1572 --------------HKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLA 1617
Query: 148 EQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEED 207
+ I E A EG + + + K S + +K + +K ++ E++ EE+
Sbjct: 1618 QAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEE 1677
Query: 208 KRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAE 267
K ++ L E K + +E+ + +L EELE +E K+ E
Sbjct: 1678 K---LAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEE 1734
Query: 268 --EEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE 325
+E K +EE+K+ EE ++ +++ K+ + + +L +E E+ + E
Sbjct: 1735 LNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQ-----EEELLIQEKEKLAQHKE 1789
Query: 326 KRKAEEE----ARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEEL 381
K EEE R ++ E+K A+ R + + EEL
Sbjct: 1790 KMPEEEERLGRKREQLIEKKMKLAQKRERWI-----------------------NSMEEL 1826
Query: 382 LKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSG 441
K KM +++ + K L EK++ Q ++ + +E L+ ++L+++K
Sbjct: 1827 TKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKER-----LTHSKKQLVQVK--- 1878
Query: 442 SIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPAR 501
K+G + +I ++EE+ + + ++ KE+ AE + V+ A+
Sbjct: 1879 -----------NKLGMFN--KILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAK 1925
Query: 502 KSEAPFTHKVNMKARFEQ---MAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEE 558
K E K MK E+ K R E +E+K L ++ ++ A +K R E
Sbjct: 1926 KQEKLAQEK--MKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKR----LAEEKMRLVE 1979
Query: 559 EEEEGSIMNGSTAEDEEQTR 578
+E ++ G T E Q +
Sbjct: 1980 GKE--TLSKGETPETSRQRK 1997
Score = 82.4 bits (202), Expect = 1e-15
Identities = 142/694 (20%), Positives = 273/694 (39%), Gaps = 88/694 (12%)
Query: 4 ISQKAEILLSSSKPVPKTYVP------KLGK--GDVKDKFEAMQRAREERNQRRSR-DEK 54
+SQ+AE L K + K + KL K G + + + + EE QR D +
Sbjct: 1651 LSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQ 1710
Query: 55 QRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQ 114
++ Q + E EW+ + KE + +E + + K + AE E+
Sbjct: 1711 EKELAQELEELEWDMEELSWKEEELNQEEGKLVEE-------------KKKLAEEEEALA 1757
Query: 115 EEQRKRTEEERKRRIEQDML--EKRKIQRELAKRAEQIEDINNTGTESASEE-------- 164
++ K +EEE K E+++L EK K+ + K E+ E + + ++
Sbjct: 1758 WQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRE 1817
Query: 165 ----GDDSLLITVVPVKSYKTSGKMKKNF-EDLEKEREEKERIKYEEDKRIRYEEQRPSL 219
+ L + + K + KKN ++ EK + KE + Y +++ ++Q +
Sbjct: 1818 RWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQV 1877
Query: 220 KEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKR 279
K + + ++E + +E + K K E E++ + A+++ + E+ K
Sbjct: 1878 KNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKL 1937
Query: 280 AFEEARRQMVNEDEENQDTAKIFKGYR--------------PGKLKLSFEEMERQRREDE 325
A E+A Q D AK K GK LS E R+ +
Sbjct: 1938 ALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRK 1997
Query: 326 KRKAEEEA-RRRIEEEKKAFAEARRNMVVDDDSPEMYK---TISQEFLTPGKLEI----- 376
+ E+E R++ E+K R + +++ K T Q G+ ++
Sbjct: 1998 MTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASR 2057
Query: 377 --------------NFEELLK--QKMEEEKRRTEEERKHKLEMEKQEF-EQLRQEMGEEE 419
++LK QK+ ++R+ +E +M++ F ++ R + + +
Sbjct: 2058 KLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSK 2117
Query: 420 EENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDL 479
+ + + S + EL K ++ + + + L +K ++ EK + EE + R+ ++
Sbjct: 2118 LDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTE---EESKLARKHSEV 2174
Query: 480 EIKEREAENFHEEDDVDV---RPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQK 536
+ + E EE+ + R ++ EA K K +F E EE E +
Sbjct: 2175 ILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKP--KEKFSSQVDEVESEEHFSEEMES 2232
Query: 537 LLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDS 596
LL +Q + + +++REEEEE E + E +E+ +K +
Sbjct: 2233 LLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
Query: 597 EPVRFTV---KVTGEPKPEITWWFEGEILQDGED 627
E + V + E K EI E E L D E+
Sbjct: 2293 EKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEE 2326
Score = 82.0 bits (201), Expect = 2e-15
Identities = 120/591 (20%), Positives = 247/591 (41%), Gaps = 65/591 (10%)
Query: 36 EAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEI---KEMLASDDEEDVSSKVEK 92
E + A+EE + +++ + KE+ E E RK+E K+M + E + +E+
Sbjct: 1766 EETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEE 1825
Query: 93 AYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIED 152
K+ K A+ +K +E+ K + + ++ L K ++L + ++
Sbjct: 1826 LTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSK--KQLVQVKNKLGM 1883
Query: 153 INNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREE--KERIKYEEDKRI 210
N + + + + K +T K+ + + L K++E+ +E++K +K +
Sbjct: 1884 FNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAM 1943
Query: 211 -----RYEEQRPSLKEAKCLSLVMDDEIESEAK----KESLSPGKLKLTFEELERQRQEN 261
R + KE K L+L M E + + KE+LS G+ E RQR+
Sbjct: 1944 VQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETP----ETSRQRKMT 1999
Query: 262 RKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYR--------------- 306
+ +Q E RK EEK E R + E E + + +G R
Sbjct: 2000 QVEQELFE-RKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRK 2058
Query: 307 -----------PGKLKLSFEEMERQRREDEKRKAEEEARRRIE-----EEKKAFAEARRN 350
P KL + +++ R++ K EE +++ +E++ E +
Sbjct: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKL 2118
Query: 351 MVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEE----RKHKLEMEKQ 406
+ + D E ++++ + + +++ + +E++ TEEE RKH +
Sbjct: 2119 DIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDD 2178
Query: 407 EFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSE--KEIQ 464
E +E G EEEE F L R + + + KR G + S+ +++ +E++
Sbjct: 2179 E-----EEGGIEEEEVIPF-LKRRWRKRKEAKR-GDKPKEKFSSQVDEVESEEHFSEEME 2231
Query: 465 KKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAR 524
++E + E +ERE E EE++V + E + ++ E+ K +
Sbjct: 2232 SLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKK 2291
Query: 525 EEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEE 575
+E+++ ++E++ + + E+ + + +EEEEEE + ++E
Sbjct: 2292 KEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKE 2342
Score = 80.9 bits (198), Expect = 4e-15
Identities = 119/529 (22%), Positives = 223/529 (42%), Gaps = 66/529 (12%)
Query: 35 FEAMQRAREERNQRRSRDEKQRRKEQ--YIREREWNRRKQEIK---------EMLASDDE 83
++ A+E++N + +++ +RKE Y +ER + +KQ ++ ++LA +E
Sbjct: 1834 YQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEE 1893
Query: 84 EDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQREL 143
+ K + + + ++E ++Q K +E+ K +E+ M++ +K R
Sbjct: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
Query: 144 AKRAEQIEDINNTGTESASE-----EGDDSLLITVVPVKSYKTSGKMKKNFEDL-EKERE 197
A++ + +N A E EG ++L P S + KM + ++L E++
Sbjct: 1954 LDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQR--KMTQVEQELFERKLS 2011
Query: 198 EKERIKYEEDKRIRYEE-------------QRPSLKEAKCLSLVMDDEIESEAKKESLS- 243
+E+I ED+ + EE QR ++ + L+ I+ K+ESLS
Sbjct: 2012 LEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIK---KRESLSK 2068
Query: 244 -PGKLKLTFEELERQRQENRKKQAEE-------------EARKRLEEEKRAFEE----AR 285
P KL + L++ ++ RK EE E R +E+ K +E +
Sbjct: 2069 EPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEK 2128
Query: 286 RQMVNEDEEN-----QDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEE 340
R + +DE+ + A + + K++ EE + R+ E +EE EEE
Sbjct: 2129 RSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEE 2188
Query: 341 KKAFAEAR---RNMVVDDDSP-EMYKTISQEFLTPGKLEINFEELLKQ--KMEEEKRRTE 394
F + R R D P E + + E + E LL + K E E
Sbjct: 2189 VIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEE 2248
Query: 395 EERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEK 454
EER+ + E E++E + +E EEEE E E E+ K K + + + FE+
Sbjct: 2249 EEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEE 2308
Query: 455 IGQLSEKEIQKKIEEERARRRAIDLEIK-EREAENFHEEDDVDVRPARK 502
++ +E + + +E + LE + +RE E +E ++ R+
Sbjct: 2309 KEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRR 2357
Score = 68.2 bits (165), Expect = 2e-11
Identities = 94/426 (22%), Positives = 176/426 (41%), Gaps = 62/426 (14%)
Query: 196 REEKERIKYEEDKRIRYEEQRPSLKEAKCL------SLVMDDEIESEAKKESL--SPGKL 247
REE++ K D + EE + LK+ K + ++ M EI + +K++ SP +
Sbjct: 1345 REEEQAQKKARDM-LGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQG 1403
Query: 248 KLTFEE------LERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQD---- 297
+ ++ ++R+ + + +EE EEK +E + M+ QD
Sbjct: 1404 RKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKA 1463
Query: 298 ----------TAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA---- 343
T K +K ++ K +E E+ + EK EEE ++E+KK
Sbjct: 1464 WDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEM---LQEDKKLKWEE 1520
Query: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEM 403
+ + NM+ + YK + E+ EE + ++ EE++++ EE++H E
Sbjct: 1521 WKQVWENMLSSKSKEQQYKD---------EEEVTLEEEVSREGEEKEQQVTEEQRHIQEE 1571
Query: 404 EKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKI-------- 455
K ++ E++ E L++E E+L + +R + + + L + KI
Sbjct: 1572 HKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMA 1631
Query: 456 ---GQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVN 512
G+ ++KE E+ + A L K ++ E+ + K N
Sbjct: 1632 QAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKN 1691
Query: 513 MKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREID-AALQKKREEEEEEEGSIM--NGS 569
+ A Q + + EQ ++K L + E+ E D L K EE +EEG ++
Sbjct: 1692 ILA---QKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKK 1748
Query: 570 TAEDEE 575
AE+EE
Sbjct: 1749 LAEEEE 1754
Score = 64.7 bits (156), Expect = 3e-10
Identities = 76/381 (19%), Positives = 181/381 (47%), Gaps = 32/381 (8%)
Query: 53 EKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQ 112
E R+++ E+E RK ++E + ++ ++ + + KL T +G+ ++ Q
Sbjct: 1991 ETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFT-RGQRIFVQGQ 2049
Query: 113 RQEEQRKRTEEERKRRIEQDMLEKRKIQRELAK-----RAEQIEDINNTGTESASEEGDD 167
R+ + R +++ + ++ + KI + L K R E+I T + A +
Sbjct: 2050 RKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKER 2109
Query: 168 SLLI--TVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCL 225
L I + + +K + S K + +D EK+ K+R + +R+ +E++ + +E+K
Sbjct: 2110 RLSIEQSKLDIKEWDFSEKRSELTKD-EKKLARKQRKLANKMRRMINKEEKMTEEESKLA 2168
Query: 226 ----SLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKK---------QAEEEARK 272
+++DDE E ++E + P + + E +R + K+ ++EE +
Sbjct: 2169 RKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSE 2228
Query: 273 RLEE-----EKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKR 327
+E EK+ + + E+EE ++ ++ + K + EE + ++ E+EK+
Sbjct: 2229 EMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKK 2288
Query: 328 KAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFE-ELLKQ-- 384
K ++E ++ +EK+ E + ++ ++++ + +E + E++ E E+LK+
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEK 2348
Query: 385 --KMEEEKRRTEEERKHKLEM 403
K++E++R++ R+ L +
Sbjct: 2349 QFKLQEQRRKSLRGRERVLSI 2369
Score = 41.2 bits (95), Expect = 0.003
Identities = 58/251 (23%), Positives = 104/251 (41%), Gaps = 27/251 (10%)
Query: 36 EAMQRAREERNQRRSRDEKQRRKE-------QYIREREWNRRKQEIKEMLASDDEEDVSS 88
E + EER + R+E++ RKE Q +E E ++K++ K+ ++E+V
Sbjct: 2248 EEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFE 2307
Query: 89 KVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAE 148
+ E+ + T ++ E E EE+ R +E K+ + + E+R+ +R
Sbjct: 2308 EKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVL 2367
Query: 149 QIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDK 208
I G A G + P+K ++ E +EK + E K
Sbjct: 2368 SILRGVPHGKGRAIRLG-----VLKSPLKKLMSTA----------LEMKEKTPVPVPE-K 2411
Query: 209 RIRYEEQRPSLKEAKCLSL-VMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAE 267
+I +E+++ ++ E L MD E E K E + P L LE Q Q+ +
Sbjct: 2412 QISWEDKKATVVEIPRKFLGTMDKEREVMGKYEPIPPHVLGTV---LESQAQDLKTPFMS 2468
Query: 268 EEARKRLEEEK 278
R+ +E E+
Sbjct: 2469 HILRRTVEAEE 2479
Score = 35.0 bits (79), Expect = 0.23
Identities = 21/94 (22%), Positives = 50/94 (53%), Gaps = 5/94 (5%)
Query: 32 KDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEI-----KEMLASDDEEDV 86
K++ E ++ E+ + + + +K+++KE+ + E K+EI E L+ ++EE+
Sbjct: 2270 KEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEE 2329
Query: 87 SSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKR 120
S +E+ + K + ++++QR++ R R
Sbjct: 2330 SCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGR 2363
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 95.1 bits (235), Expect = 2e-19
Identities = 97/441 (21%), Positives = 209/441 (47%), Gaps = 50/441 (11%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE--IKEMLASDDEEDVS 87
++K K E + + Q R ++ + R +E +RE+E R+QE ++E E++
Sbjct: 36 ELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 95
Query: 88 SKVEKAYVPKLTGTVK---GRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKR--KIQRE 142
+ ++ V + G V+ G+ E E Q +E++ + E+E + R ++ + ++ +++ +
Sbjct: 96 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 155
Query: 143 LAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERI 202
+ EQ + + +EG V + + + + E E+ E++E++
Sbjct: 156 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQM 215
Query: 203 KYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENR 262
+ +E++ EEQ +E M ++ E K+E E++++Q ++ R
Sbjct: 216 QKQEEQMGEQEEQMRKQEEQ------MGEQEEQVQKQE-----------EQVQKQEEQMR 258
Query: 263 KKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRR 322
K +EE + EE+ R EE + + E+ + T G+ + E E Q R
Sbjct: 259 K---QEEQMREQEEQMREQEEQMLKQKEQTEQEEQT---------GEQEEQMREQEEQMR 306
Query: 323 EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELL 382
E E++ E+E + R +EE+ E + + + +M++ +E + + ++ +E
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQ----MWEQKEQMWE--QKEQMWKQEEQMGEQEEQ 360
Query: 383 KQKMEEEKRRTEEE-RKHKLEMEKQEFEQLRQE--MGEEEEENETFGLSREYEELIKLKR 439
QK EE+ R+ EE+ RK + +M KQE + +QE MGE++E+ + + E++ + +
Sbjct: 361 MQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQ-----MGEQKEQMREQEE 415
Query: 440 SGSIQAKNLKSKFEKIGQLSE 460
Q + ++ + E +G+ E
Sbjct: 416 QMGEQKEQMRKQEEHMGEQKE 436
Score = 90.5 bits (223), Expect = 5e-18
Identities = 84/421 (19%), Positives = 201/421 (47%), Gaps = 60/421 (14%)
Query: 17 PVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQE--I 74
P+P+ + +G V+ E + RE+ Q R ++ + R +E +RE+E R+QE +
Sbjct: 47 PLPQEGQVREQEGQVR---EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 103
Query: 75 KEMLASDDEEDVSSKVEKAYVPKLTGTVK---GRFAEMEKQRQEEQRKRTEEERKRRIEQ 131
+E E++ + ++ V + G V+ G+ E E Q +E++ + E+E + R ++
Sbjct: 104 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 163
Query: 132 DMLEKRK--IQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNF 189
+ +++ ++ + + EQ + + +EG G+ ++
Sbjct: 164 GQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQ---------------MGEQEEQM 208
Query: 190 EDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKL 249
+ E++ +++E E+++++R +E++ M ++ E K+E
Sbjct: 209 GEQEEQMQKQEEQMGEQEEQMRKQEEQ------------MGEQEEQVQKQE--------- 247
Query: 250 TFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309
E++++Q ++ RK +EE + EE+ R EE + + E+ + T + + R +
Sbjct: 248 --EQVQKQEEQMRK---QEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 310 LKLSFEEMERQRREDEKRKAEEEARRRIE---EEKKAFAEARRNMVVDDDS---PEMYKT 363
++ +E + + +E++ R+ EE+ ++ E E+K+ E + M ++ E
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ 362
Query: 364 ISQEFLTPGKLEINFEELLKQKMEEEKRRTEE---ERKHKLEMEKQEFEQLRQEMGEEEE 420
+E + + ++ +E +K EE+ R+ EE E+K ++ +K++ + ++MGE++E
Sbjct: 363 KQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKE 422
Query: 421 E 421
+
Sbjct: 423 Q 423
Score = 74.3 bits (181), Expect = 3e-13
Identities = 94/499 (18%), Positives = 229/499 (45%), Gaps = 89/499 (17%)
Query: 95 VPKLTGT-VKGRFAEMEKQRQEEQRKRTE-----EERKRRIEQDML---EKRKIQRELAK 145
+P++T +K + AE++++ Q + +++E +E KR++E D + ++ +++ + +
Sbjct: 1 MPRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQ 60
Query: 146 RAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYE 205
EQ + + +EG + E + E+E E
Sbjct: 61 VREQEGQVREQEGQVREQEGQ----------------------VREQEGQVREQEGQVRE 98
Query: 206 EDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQ 265
++ ++R +E + +E + V + E + ++ + + ++ +E + + QE + ++
Sbjct: 99 QEGQVREQEGQVREQEGQ----VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 154
Query: 266 AEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDE 325
E + R++ E + R E R+ + E + + +G E E Q E E
Sbjct: 155 QEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEG--------QMGEQEGQMGEQE 205
Query: 326 KRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQK 385
++ E+E + + +EE+ + + +M K +E + + ++ +E QK
Sbjct: 206 EQMGEQEEQMQKQEEQ-----------MGEQEEQMRK--QEEQMGEQEEQVQKQEEQVQK 252
Query: 386 MEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQA 445
EE+ R+ EE+ + + E +++ EQ+ ++ + E+E +T E EE ++
Sbjct: 253 QEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQT----GEQEEQMR--------- 299
Query: 446 KNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEA 505
E+ Q+ E+E Q + +EE+ R + + ++ ++E + + +++ + + E
Sbjct: 300 -------EQEEQMREQEEQMREQEEQMREQ--EEQMGKQEEQMWEQKEQM----WEQKEQ 346
Query: 506 PFTHKVNMKARFEQMAK----AREEEEQRRIEEQKLLRMQFEQREIDAALQKKREE--EE 559
+ + M + EQM K R++EEQ R +E+++ + + + R+ + + +++E+ E+
Sbjct: 347 MWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQ 406
Query: 560 EEEGSIMNGSTAEDEEQTR 578
+E+ E +EQ R
Sbjct: 407 KEQMREQEEQMGEQKEQMR 425
Score = 71.2 bits (173), Expect = 3e-12
Identities = 81/391 (20%), Positives = 186/391 (47%), Gaps = 28/391 (7%)
Query: 194 KEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEE 253
K + E ++I ++ ++R +E + +E + V + E + ++ + + ++ +E
Sbjct: 38 KRKLETDKIPLPQEGQVREQEGQVREQEGQ----VREQEGQVREQEGQVREQEGQVREQE 93
Query: 254 LERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGY---RPGKL 310
+ + QE + ++ E + R++ E + R E R+ + E + + +G + G++
Sbjct: 94 GQVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 152
Query: 311 KLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLT 370
+ E E Q RE E + E+E + R +E + E + V + +M + Q +
Sbjct: 153 R----EQEGQVREQEGQVREQEGQVREQEGQVREQEGQ----VREQEGQMGEQEGQ--MG 202
Query: 371 PGKLEINFEELLKQKMEEEKRRTEEE-RKHKLEMEKQEFEQLRQEMGEEEEENETFGLSR 429
+ ++ +E QK EE+ EE+ RK + +M +QE + +QE +++E +
Sbjct: 203 EQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEE 262
Query: 430 EYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENF 489
+ E + R Q K + E+ Q E+E Q + +EE+ R + + +++E+E +
Sbjct: 263 QMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQ--EEQMREQEEQMR 320
Query: 490 HEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDA 549
+E+ + ++ E + K M + EQM K +EEQ +E+++ + + + R+ +
Sbjct: 321 EQEEQM----GKQEEQMWEQKEQMWEQKEQMWK---QEEQMGEQEEQMQKQEEQVRKQEE 373
Query: 550 ALQKKREEEEEEEGSIMNGSTAEDEEQTRSG 580
++K+ E+ ++E + E++ + G
Sbjct: 374 QMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404
Score = 68.9 bits (167), Expect = 1e-11
Identities = 92/481 (19%), Positives = 211/481 (43%), Gaps = 106/481 (22%)
Query: 11 LLSSSKPVPKTYVPKLGKGDVKDKFEAMQ--RAREERNQRRSRDEKQRRKEQYIREREWN 68
L+ + K + ++ +L + DK Q + RE+ Q R ++ + R +E +RE+E
Sbjct: 22 LVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 81
Query: 69 RRKQE--IKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERK 126
R+QE ++E E++ + ++ V + G V+ E E Q +E++ + E+E +
Sbjct: 82 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR----EQEGQVREQEGQVREQEGQ 137
Query: 127 RRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMK 186
R ++ + R+ + ++ ++ Q+ + +EG
Sbjct: 138 VREQEGQV--REQEGQVREQEGQVRE----------QEG--------------------- 164
Query: 187 KNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGK 246
+ RE++ +++ E++ ++R EQ ++E E + ++ G+
Sbjct: 165 -------QVREQEGQVR-EQEGQVR--EQEGQVREQ-----------EGQMGEQEGQMGE 203
Query: 247 LKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYR 306
+ E E Q Q+ ++ E+E + R +EE+ +E + Q E + Q+
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQE--------- 254
Query: 307 PGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQ 366
E+M +Q E++ R+ EE+ R + E+ K + + + +M + Q
Sbjct: 255 --------EQMRKQ--EEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQ 304
Query: 367 EFLTPGKLEINFEELLKQKMEEEKRRTEE----------ERKHKLEMEKQEFEQLRQEMG 416
+ +E ++ EE+ R EE E+K ++ +K++ + ++MG
Sbjct: 305 ---------MREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMG 355
Query: 417 EEEE--ENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIG----QLSEKEIQKKIEEE 470
E+EE + + + ++ E++ K + Q + ++ + E++G Q+ E++ Q + +EE
Sbjct: 356 EQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEE 415
Query: 471 R 471
+
Sbjct: 416 Q 416
Score = 66.2 bits (160), Expect = 9e-11
Identities = 80/383 (20%), Positives = 172/383 (44%), Gaps = 41/383 (10%)
Query: 232 EIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNE 291
E++ E + +++L +EL+R+ + ++ +E + E + R E R+ +
Sbjct: 15 ELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQ 74
Query: 292 DEENQDTAKIFKGY---RPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEAR 348
E + + +G + G+++ E E Q RE E + E+E + R E+E + +
Sbjct: 75 VREQEGQVREQEGQVREQEGQVR----EQEGQVREQEGQVREQEGQVR-EQEGQVREQEG 129
Query: 349 RNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEE---RKHKLEMEK 405
+ + E + ++ + E E Q E+E + E+E R+ + ++ +
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 189
Query: 406 QEFEQLRQE--MGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIG------Q 457
QE + QE MGE+EE+ + + E++ K + Q + ++ + E++G Q
Sbjct: 190 QEGQMGEQEGQMGEQEEQ-----MGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQ 244
Query: 458 LSEKEIQKKIE-----EERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVN 512
E+++QK+ E EE+ R + + +E + E+ + + + + E +
Sbjct: 245 KQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQ 304
Query: 513 MKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREE---------EEEEEG 563
M+ + EQM RE+EEQ R +E+++ + + + E + +++E+ E+EE+
Sbjct: 305 MREQEEQM---REQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQM 361
Query: 564 SIMNGSTAEDEEQTRSGAPWFKK 586
+ EEQ R +K
Sbjct: 362 QKQEEQVRKQEEQMRKQEEQMRK 384
Score = 65.1 bits (157), Expect = 2e-10
Identities = 85/408 (20%), Positives = 187/408 (45%), Gaps = 31/408 (7%)
Query: 188 NFEDLEKEREEKERIKYEEDKRIRYEEQRPSLK---EAKCLSLVMDDEIESEAKKESLSP 244
N E EK E +E ++ E ++ + LK E + L + ++ + +
Sbjct: 6 NEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQE 65
Query: 245 GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKG 304
G+++ E E Q +E + E+E + R E+E + E+ + E + + ++ +
Sbjct: 66 GQVR----EQEGQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQVRE- 119
Query: 305 YRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTI 364
+ G+++ E E Q RE E + E+E + R +E + E + V + ++ +
Sbjct: 120 -QEGQVR----EQEGQVREQEGQVREQEGQVREQEGQVREQEGQ----VREQEGQVREQE 170
Query: 365 SQEFLTPGKLEINFEELLKQK--MEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEE- 421
Q G++ ++ +Q+ M E++ + E+ + E E+Q +Q ++MGE+EE+
Sbjct: 171 GQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQ-EEQMGEQEEQM 229
Query: 422 -NETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLE 480
+ + + E++ K + Q + ++ + E Q+ E+E Q + +EE+ ++ E
Sbjct: 230 RKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEE---QMREQEEQMREQEEQMLKQKEQTE 286
Query: 481 IKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREE--EEQRRIEEQKLL 538
+E+ E + + + + + E + M+ + EQM K E+ E++ ++ EQK
Sbjct: 287 QEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK-- 344
Query: 539 RMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKK 586
Q ++E Q+++ +++EE+ + EEQ R +K
Sbjct: 345 -EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRK 391
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 92.4 bits (228), Expect = 1e-18
Identities = 80/309 (25%), Positives = 161/309 (52%), Gaps = 44/309 (14%)
Query: 36 EAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYV 95
E ++ +E+ + R ++EK RR+E+ + E+E R+QE EM+ + EE + EK +
Sbjct: 299 EREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQE--EMM-WEKEEKIRELEEKMHE 355
Query: 96 PKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
+ + E E++RQEE++ R +E+R+ + + ++ KI+ + K EQ E++
Sbjct: 356 QE-------KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ-EEMMQ 407
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQ 215
E E+ + K ++ +M+ E EK R ++E+I+ E++K+IR +E+
Sbjct: 408 EQEEKMGEQEE----------KMWEQEEEMQ---EQEEKMRRQEEKIR-EQEKKIREQEE 453
Query: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEAR---K 272
+ + + E + ++E + + K+ +E + Q QE + ++ EE+ R K
Sbjct: 454 K-----------IREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEK 502
Query: 273 RLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEE 332
++ E++ E + +M+ E EE + + K++ E+ E+ RR++EK + E+E
Sbjct: 503 KIREQEEKIRE-QEEMMQEQEEKMWEQEEKMCEQEEKMQ---EQEEKMRRQEEKMR-EQE 557
Query: 333 ARRRIEEEK 341
R R +EEK
Sbjct: 558 VRLRQQEEK 566
Score = 90.9 bits (224), Expect = 3e-18
Identities = 117/516 (22%), Positives = 235/516 (45%), Gaps = 51/516 (9%)
Query: 52 DEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEK 111
++K + Q RE + Q I+ + E ++ + V +L G + + +
Sbjct: 98 EQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 157
Query: 112 QRQEEQRKRTEEERKRRIEQDMLEKRKIQR---ELAKRAE--QIEDINNTGTESASEEGD 166
+ E ++ + +K+K R EL K + +E NT T+ +E +
Sbjct: 158 SW------KFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 211
Query: 167 DSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLS 226
L + V+S K+ +++ N ++L+++ E + + ++ + + KE + +S
Sbjct: 212 AKLQEKLQLVESEKS--EIQLNVKELKRKLERAKLLLPQQQLQAEADHLG---KELQSVS 266
Query: 227 LVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARR 286
+ ++E L+ + + + + E + QE +K E+E + R +EEK +E
Sbjct: 267 AKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQEREEKIQEQEEKIREQEEKMRRQEEMM 325
Query: 287 QMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAE 346
E Q+ K + +L+ E E+ R ++EKR+ EE+ R E+EK+ E
Sbjct: 326 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR---EQEKRQEQE 382
Query: 347 ARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEER-KHKLEMEK 405
A+ M++ +E + + +I +E + Q+ EE+ EE+ + + EM++
Sbjct: 383 AK-----------MWR--QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQE 429
Query: 406 QEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQK 465
QE + RQE E+E + RE EE K++ + + + E+ G++ E+E +
Sbjct: 430 QEEKMRRQEEKIREQEKKI----REQEE--KIREQEEMMQEQEEKMGEQEGKMCEQEAKM 483
Query: 466 KIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKARE 525
+ +EE+ RR+ E K RE E E + +R + K+ +EQ K E
Sbjct: 484 QEQEEKMRRQ----EEKIREQEKKIREQEEKIREQEEMMQEQEEKM-----WEQEEKMCE 534
Query: 526 EEEQRRIE-EQKLLRMQFEQREIDAALQKKREEEEE 560
+EE + E E+K+ R + + RE + L+++ E+ +E
Sbjct: 535 QEE-KMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 77.0 bits (188), Expect = 5e-14
Identities = 90/397 (22%), Positives = 177/397 (44%), Gaps = 57/397 (14%)
Query: 40 RAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDD---EEDVSSKVEKAYVP 96
+ + + Q + + + + E + +E R+ + K +L E D K ++
Sbjct: 208 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 267
Query: 97 KLTGTVK-GRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINN 155
KL V+ Q+QEE+ R EE+ + R E+ ++ KI+ + K Q E +
Sbjct: 268 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWE 327
Query: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKR-----I 210
+ +E + + ++ +LE++ E+E+I+ +E+KR I
Sbjct: 328 KEEKMRRQE---------------EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 372
Query: 211 RYEEQRPSLKEAKCL----------SLVMDDEIESEAKKESLSPGKLKLTFEELERQRQE 260
R +E+R +EAK + + E + ++E + + K+ +E E Q QE
Sbjct: 373 REQEKRQE-QEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQE 431
Query: 261 NRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQ 320
+ ++ EE+ R E+EK+ E+ + + E EE + G + G K+ +E + Q
Sbjct: 432 EKMRRQEEKIR---EQEKKIREQ--EEKIREQEEMMQEQEEKMGEQEG--KMCEQEAKMQ 484
Query: 321 RREDEKRKAEEEAR---RRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEIN 377
+E++ R+ EE+ R ++I E+++ E M ++ K QE E
Sbjct: 485 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE-----KMWEQE-------EKM 532
Query: 378 FEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQE 414
E+ K + +EEK R +EE+ + E+ ++ E+ QE
Sbjct: 533 CEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 73.6 bits (179), Expect = 6e-13
Identities = 101/467 (21%), Positives = 205/467 (43%), Gaps = 34/467 (7%)
Query: 133 MLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLL--ITVVPVKSYKTSGKMKKNFE 190
M+ K Q +LA+ EQ+ D + S D+ I TSG +
Sbjct: 38 MMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPED 97
Query: 191 DLEKEREEKERIKYEEDKRIRYEE----QRPSLKEAKCLSLVMDDEIESEAKKESLSPGK 246
+ + + +E ++ E + +++ Q+ L+ A S ++E EA+ + +S
Sbjct: 98 EQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEAR-DLISRLH 156
Query: 247 LKLTFE-ELERQRQE--NRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFK 303
F ELE+ +KK+A+ + +E E R + ++E + AK+ +
Sbjct: 157 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 216
Query: 304 GYR-----PGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSP 358
+ +++L+ +E++R+ + +++ + + K + +
Sbjct: 217 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 276
Query: 359 EMYKTISQ---EFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEM--EKQEFEQLRQ 413
E++ ++Q E + + +I E Q+ EE+ R EE+ + + EM EK+E + ++
Sbjct: 277 ELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 336
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERAR 473
EM E+EE RE EE K+ I+ + K + E+ + EK +++ + R
Sbjct: 337 EMMWEKEEK-----IRELEE--KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 389
Query: 474 RRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE 533
+ + E K RE E +E + + + E + + M+ EQ K R +EE+ R +
Sbjct: 390 EKIREQEEKIREQEEMMQEQEEKM--GEQEEKMWEQEEEMQ---EQEEKMRRQEEKIREQ 444
Query: 534 EQKLLRMQFEQREIDAALQKKREEEEEEEGSI--MNGSTAEDEEQTR 578
E+K+ + + RE + +Q++ E+ E+EG + E EE+ R
Sbjct: 445 EKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMR 491
Score = 70.1 bits (170), Expect = 6e-12
Identities = 62/251 (24%), Positives = 129/251 (51%), Gaps = 34/251 (13%)
Query: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSK 89
++++K ++ RE+ E++R++E+ IRE+E R++QE K + + K
Sbjct: 348 ELEEKMHEQEKIREQ--------EEKRQEEEKIREQE-KRQEQEAKMWRQEEKIREQEEK 398
Query: 90 VEKAYVPKLTGTVKGRFAEMEKQ--RQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRA 147
+ + ++ + + E E++ QEE+ + EE+ +R+ E+ +++KI+ + K
Sbjct: 399 IREQ--EEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR 456
Query: 148 EQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEED 207
EQ E + + +EG K + KM+ E EK R ++E+I+ E++
Sbjct: 457 EQEEMMQEQEEKMGEQEG-----------KMCEQEAKMQ---EQEEKMRRQEEKIR-EQE 501
Query: 208 KRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAE 267
K+IR +E++ +E ++ + E + ++E + + K+ +E + +RQE +K E
Sbjct: 502 KKIREQEEKIREQE----EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE--EKMRE 555
Query: 268 EEARKRLEEEK 278
+E R R +EEK
Sbjct: 556 QEVRLRQQEEK 566
Score = 38.9 bits (89), Expect = 0.016
Identities = 57/355 (16%), Positives = 137/355 (38%), Gaps = 21/355 (5%)
Query: 252 EELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLK 311
+E + + K+Q + + A + +++ +N + T + K
Sbjct: 41 KETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQK 100
Query: 312 LSFEEMERQRREDEKRKAEEEAR--RRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL 369
S + E RRE E + ++ E + + ++ ++ ++ + +
Sbjct: 101 ASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWK 160
Query: 370 TPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSR 429
G+LE + QK + + R EE K E + E R + +EE + + L
Sbjct: 161 FAGELEQALSAVATQKKKAD-RYIEELTK---ERDALSLELYRNTITDEELKEKNAKLQE 216
Query: 430 EYEELIKLKRSGSIQAKNLKSKFEKIGQL-SEKEIQKKIEEERARRRAIDLEIKEREAEN 488
+ + + K + K LK K E+ L ++++Q + + +++ +++ + EN
Sbjct: 217 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 276
Query: 489 --------------FHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEE 534
+ +E+ + R + E + + Q E+EE+ R +E
Sbjct: 277 ELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 336
Query: 535 QKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLK 589
+ + + + RE++ + ++ + E+EE E E++ A +++ K
Sbjct: 337 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 391
>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
Length = 558
Score = 92.4 bits (228), Expect = 1e-18
Identities = 96/401 (23%), Positives = 185/401 (46%), Gaps = 36/401 (8%)
Query: 107 AEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGD 166
+++ QR ++ + ER+RR Q+ L +++ + L + +Q+E N EE
Sbjct: 17 SQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV--NAQNSVPDEEAK 74
Query: 167 DSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLS 226
+ T V G + F + REE+ + + +E R +E P++ +A LS
Sbjct: 75 TTTTNTQV-------EGDDEAAFLERLARREERRQKRLQEALE-RQKEFDPTITDAS-LS 125
Query: 227 L----VMDDEIESEA--KKESLSPGKLKLTFEELE---RQRQENRKKQAEEEARKRLEEE 277
L + +D E+E K+E + + EE E + Q+N + AEE ++ E+E
Sbjct: 126 LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE 185
Query: 278 KRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRI 337
+ E+ +R + E++ + K+ + KL+ +++ +DEK K ++E + +
Sbjct: 186 EEEEEKPKRGSIGENQGEEKGTKVQA--KREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV 243
Query: 338 E---EEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPG-KLEINFEELLKQKMEEEKRRT 393
+ + KK F E + + K F PG + ++ +E E +R
Sbjct: 244 KSFMDRKKGFTEVKSQN--GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL 301
Query: 394 EEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFE 453
EE R+ + E E +EFE+L+Q+ E E E RE +R ++ + + K E
Sbjct: 302 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE-------ERRKVLEEEEQRRKQE 354
Query: 454 KIG-QLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEED 493
+ +L E+E +++++EE RRRA E +++ E+ +D
Sbjct: 355 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDD 395
Score = 87.4 bits (215), Expect = 4e-17
Identities = 117/468 (25%), Positives = 201/468 (42%), Gaps = 76/468 (16%)
Query: 47 QRRSRDEKQRRKEQYIREREWN-RRKQEIKEMLASDDEEDVSSKV----EKAYVPKLTGT 101
QR DE++ +E+ R R+ R+KQE + + D+ +V+++ E+A
Sbjct: 22 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ 81
Query: 102 VKG----RFAEMEKQRQEEQRKRTEEERKRRIEQD--------MLEKRKIQRELAKRAEQ 149
V+G F E +R+E ++KR +E +R+ E D L R++Q + A+
Sbjct: 82 VEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAEN--- 138
Query: 150 IEDINNTGTESASEEGDDSLLI--TVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEED 207
T E SE + I T KSY+ + ++ E+ +KE +EKE + E+
Sbjct: 139 ----ETTEKEEKSESRQERYEIEETETVTKSYQKND--WRDAEENKKEDKEKEEEEEEKP 192
Query: 208 KRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAE 267
KR E + K K +AK+E L K TF++ E + ++ +K +
Sbjct: 193 KRGSIGENQGEEKGTKV-----------QAKREKLQED--KPTFKKEEIKDEKIKKDKEP 239
Query: 268 EEARKRLEEEKRAFEEARRQ----MVNEDEENQDTAKIFKGYRP-GKLKLSFEEMERQRR 322
+E K + K+ F E + Q M ++ + ++T RP G+ + +E E +
Sbjct: 240 KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS-----RPGGRASVDTKEAEGAPQ 294
Query: 323 EDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELL 382
+ ++ EE RRR E E + F + ++ + L +L+ EE
Sbjct: 295 VEAGKRLEELRRRRGETESEEFEKLKQKQ-------------QEAALELEELKKKREERR 341
Query: 383 KQKMEEEKRRTEEERKHKLEME------KQEFEQLRQEMGEEEEENETFGLSREYEELIK 436
K EEE+RR +EE KL E K+E E+ R E E+ ++ GLS + +
Sbjct: 342 KVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKC 401
Query: 437 LKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKER 484
GS K E+ + K +QK + + AI +I R
Sbjct: 402 FTPKGS------SLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 443
Score = 77.8 bits (190), Expect = 3e-14
Identities = 91/409 (22%), Positives = 175/409 (42%), Gaps = 46/409 (11%)
Query: 191 DLEKEREEKERIKYEEDKRIRYEEQRPSLK------EAKCLSLVMDDEIESEAKKESLSP 244
D ++E +ER + +R+R +++ SL E + V D+E ++ +
Sbjct: 25 DDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE- 83
Query: 245 GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEA----RRQMVNEDEENQDTAK 300
G + F E +R+E R+K+ +E ++ E + + + R+M N+ EN+ T K
Sbjct: 84 GDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEK 143
Query: 301 IFKGYRPGKLKLSFEEMERQRREDEK---RKAEEEARRRIEEEKKAFAEARRNMVVDDDS 357
K + + EE E + +K R AEE + E+E++ + +R + ++
Sbjct: 144 EEKS-ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQG 202
Query: 358 PEMYKTIS--QEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEM 415
E + +E L K EE+ +K++++K EE + K+ F +++ +
Sbjct: 203 EEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFM--DRKKGFTEVKSQN 260
Query: 416 GEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRR 475
GE T L + S+ K + + E K++EE R RR
Sbjct: 261 GEFM----THKLKHTENTFSRPGGRASVDTKEAEGA-------PQVEAGKRLEELRRRRG 309
Query: 476 AIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQ 535
E E+E F + A + E +K + E+ K EEEEQRR +E+
Sbjct: 310 -------ETESEEFEKLKQKQQEAALELE-------ELKKKREERRKVLEEEEQRRKQEE 355
Query: 536 --KLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAP 582
+ LR + E+R + ++++R E E+ + ++D++ + P
Sbjct: 356 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTP 404
Score = 65.9 bits (159), Expect = 1e-10
Identities = 90/371 (24%), Positives = 170/371 (45%), Gaps = 61/371 (16%)
Query: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKE--QYIREREWN---RRKQEIKEMLASDD 82
+GD + F REER Q+R ++ +R+KE I + + RR Q + +
Sbjct: 83 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
Query: 83 EEDVSSKVEKAYVPKLTGTV-----KGRFAEMEKQRQEEQRKRTEEERKRR---IEQDML 134
+E+ S ++ Y + T TV K + + E+ ++E++ K EEE K + I ++
Sbjct: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQG 202
Query: 135 EKR--KIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDL 192
E++ K+Q AKR + ED T E D+ + P + K+ KK F ++
Sbjct: 203 EEKGTKVQ---AKREKLQED---KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 256
Query: 193 EKEREE--KERIKYEEDKRIR----------YEEQRPSLKEAKCLSLVMDDEIESEAKK- 239
+ + E ++K+ E+ R E P ++ K L + E+E+++
Sbjct: 257 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 316
Query: 240 ESLSPGKLK--LTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQD 297
E L + + L EEL+++R+E RK EEE R++ EE R + E+EE +
Sbjct: 317 EKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADR--------KLREEEEKR- 367
Query: 298 TAKIFKGYRPGKLKLSFEEMERQRRE--DEKRKAEEEARRRIEEEKKAFAEARRNMVVDD 355
+LK EE+ER+R E ++++K E+ ++ K F ++ +++
Sbjct: 368 -----------RLK---EEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEE 413
Query: 356 DSPEMYKTISQ 366
+ + K++ +
Sbjct: 414 RAEFLNKSVQK 424
Score = 50.4 bits (119), Expect = 5e-06
Identities = 63/292 (21%), Positives = 124/292 (42%), Gaps = 54/292 (18%)
Query: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREER----------NQRRSRDEK 54
S++ + ++ V K+Y + ++K E ++ EE NQ + K
Sbjct: 149 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTK 208
Query: 55 QRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQ 114
+ K + ++E + +K+EIK DE+ K K V KG F E++ Q
Sbjct: 209 VQAKREKLQEDKPTFKKEEIK------DEKIKKDKEPKEEVKSFMDRKKG-FTEVKSQNG 261
Query: 115 E---EQRKRTEEERKRRIEQDMLEKRKIQ-RELAKRAEQIEDINNTGTESASEEGDDSLL 170
E + K TE R + ++ ++ + + +++E++ E+ SEE +
Sbjct: 262 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE---- 317
Query: 171 ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMD 230
K + + E+L+K+REE+ ++ EE++R + EE D
Sbjct: 318 ------KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE--------------AD 357
Query: 231 DEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFE 282
++ E +K L EE+ER+R E +K+ ++ L ++K+ F+
Sbjct: 358 RKLREEEEKRRLK--------EEIERRRAEAAEKR-QKMPEDGLSDDKKPFK 400
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/202 (22%), Positives = 83/202 (41%), Gaps = 33/202 (16%)
Query: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRE 64
SQ E + K T+ G+ V K EA + E +R E+ RR+
Sbjct: 258 SQNGEFMTHKLKHTENTFSRPGGRASVDTK-EAEGAPQVEAGKRL---EELRRRRGETES 313
Query: 65 REWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE 124
E+ + KQ+ +++ + ++E+ K+++EE+RK EEE
Sbjct: 314 EEFEKLKQK---------QQEAALELEEL-----------------KKKREERRKVLEEE 347
Query: 125 RKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSG- 183
+RR +++ K + + E + E+IE E + +D L P K + G
Sbjct: 348 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS 407
Query: 184 --KMKKNFEDLEKEREEKERIK 203
K+++ E L K ++ +K
Sbjct: 408 SLKIEERAEFLNKSVQKSSGVK 429
>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
Length = 564
Score = 92.0 bits (227), Expect = 2e-18
Identities = 96/396 (24%), Positives = 182/396 (45%), Gaps = 36/396 (9%)
Query: 112 QRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLI 171
QR ++ + ER+RR Q+ L +++ + L + +Q+E N EE +
Sbjct: 28 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV--NAQNSVPDEEAKTTTTN 85
Query: 172 TVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSL---- 227
T V G + F + REE+ + + +E R +E P++ +A LSL
Sbjct: 86 TQV-------EGDDEAAFLERLARREERRQKRLQEALE-RQKEFDPTITDAS-LSLPSRR 136
Query: 228 VMDDEIESEA--KKESLSPGKLKLTFEELE---RQRQENRKKQAEEEARKRLEEEKRAFE 282
+ +D E+E K+E + + EE E + Q+N + AEE ++ E+E+ E
Sbjct: 137 MQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEE 196
Query: 283 EARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIE---E 339
+ +R + E++ + K+ + KL+ +++ +DEK K ++E + ++ +
Sbjct: 197 KPKRGSIGENQGEEKGTKVQA--KREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMD 254
Query: 340 EKKAFAEARRNMVVDDDSPEMYKTISQEFLTPG-KLEINFEELLKQKMEEEKRRTEEERK 398
KK F E + + K F PG + ++ +E E +R EE R+
Sbjct: 255 RKKGFTEVKSQN--GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR 312
Query: 399 HKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIG-Q 457
+ E E +EFE+L+Q+ E E E RE +R ++ + + K E+ +
Sbjct: 313 RRGETESEEFEKLKQKQQEAALELEELKKKRE-------ERRKVLEEEEQRRKQEEADRK 365
Query: 458 LSEKEIQKKIEEERARRRAIDLEIKEREAENFHEED 493
L E+E +++++EE RRRA E +++ E+ +D
Sbjct: 366 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDD 401
Score = 88.2 bits (217), Expect = 2e-17
Identities = 122/493 (24%), Positives = 210/493 (42%), Gaps = 84/493 (17%)
Query: 30 DVKDKFEAMQRAREERN--------QRRSRDEKQRRKEQYIREREWN-RRKQEIKEMLAS 80
D + + E ++ REE QR DE++ +E+ R R+ R+KQE + +
Sbjct: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
Query: 81 DDEEDVSSKV----EKAYVPKLTGTVKG----RFAEMEKQRQEEQRKRTEEERKRRIEQD 132
D+ +V+++ E+A V+G F E +R+E ++KR +E +R+ E D
Sbjct: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
Query: 133 --------MLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLI--TVVPVKSYKTS 182
L R++Q + A+ T E SE + I T KSY+ +
Sbjct: 123 PTITDASLSLPSRRMQNDTAEN-------ETTEKEEKSESRQERYEIEETETVTKSYQKN 175
Query: 183 GKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESL 242
++ E+ +KE +EKE + E+ KR E + K K +AK+E L
Sbjct: 176 D--WRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKV-----------QAKREKL 222
Query: 243 SPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQ----MVNEDEENQDT 298
K TF++ E + ++ +K + +E K + K+ F E + Q M ++ + ++T
Sbjct: 223 QED--KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 280
Query: 299 AKIFKGYRP-GKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDS 357
RP G+ + +E E + + ++ EE RRR E E + F + ++
Sbjct: 281 FS-----RPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQ------ 329
Query: 358 PEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEME------KQEFEQL 411
+ L +L+ EE K EEE+RR +EE KL E K+E E+
Sbjct: 330 -------QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERR 382
Query: 412 RQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEER 471
R E E+ ++ GLS + + GS K E+ + K +QK +
Sbjct: 383 RAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS------SLKIEERAEFLNKSVQKSSGVKS 436
Query: 472 ARRRAIDLEIKER 484
+ AI +I R
Sbjct: 437 THQAAIVSKIDSR 449
Score = 77.8 bits (190), Expect = 3e-14
Identities = 91/409 (22%), Positives = 175/409 (42%), Gaps = 46/409 (11%)
Query: 191 DLEKEREEKERIKYEEDKRIRYEEQRPSLK------EAKCLSLVMDDEIESEAKKESLSP 244
D ++E +ER + +R+R +++ SL E + V D+E ++ +
Sbjct: 31 DDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE- 89
Query: 245 GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEA----RRQMVNEDEENQDTAK 300
G + F E +R+E R+K+ +E ++ E + + + R+M N+ EN+ T K
Sbjct: 90 GDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEK 149
Query: 301 IFKGYRPGKLKLSFEEMERQRREDEK---RKAEEEARRRIEEEKKAFAEARRNMVVDDDS 357
K + + EE E + +K R AEE + E+E++ + +R + ++
Sbjct: 150 EEKS-ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQG 208
Query: 358 PEMYKTIS--QEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEM 415
E + +E L K EE+ +K++++K EE + K+ F +++ +
Sbjct: 209 EEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFM--DRKKGFTEVKSQN 266
Query: 416 GEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRR 475
GE T L + S+ K + + E K++EE R RR
Sbjct: 267 GEFM----THKLKHTENTFSRPGGRASVDTKEAEGA-------PQVEAGKRLEELRRRRG 315
Query: 476 AIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQ 535
E E+E F + A + E +K + E+ K EEEEQRR +E+
Sbjct: 316 -------ETESEEFEKLKQKQQEAALELE-------ELKKKREERRKVLEEEEQRRKQEE 361
Query: 536 --KLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAP 582
+ LR + E+R + ++++R E E+ + ++D++ + P
Sbjct: 362 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTP 410
Score = 65.9 bits (159), Expect = 1e-10
Identities = 90/371 (24%), Positives = 170/371 (45%), Gaps = 61/371 (16%)
Query: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKE--QYIREREWN---RRKQEIKEMLASDD 82
+GD + F REER Q+R ++ +R+KE I + + RR Q + +
Sbjct: 89 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 148
Query: 83 EEDVSSKVEKAYVPKLTGTV-----KGRFAEMEKQRQEEQRKRTEEERKRR---IEQDML 134
+E+ S ++ Y + T TV K + + E+ ++E++ K EEE K + I ++
Sbjct: 149 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQG 208
Query: 135 EKR--KIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDL 192
E++ K+Q AKR + ED T E D+ + P + K+ KK F ++
Sbjct: 209 EEKGTKVQ---AKREKLQED---KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 262
Query: 193 EKEREE--KERIKYEEDKRIR----------YEEQRPSLKEAKCLSLVMDDEIESEAKK- 239
+ + E ++K+ E+ R E P ++ K L + E+E+++
Sbjct: 263 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 322
Query: 240 ESLSPGKLK--LTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQD 297
E L + + L EEL+++R+E RK EEE R++ EE R + E+EE +
Sbjct: 323 EKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADR--------KLREEEEKR- 373
Query: 298 TAKIFKGYRPGKLKLSFEEMERQRRE--DEKRKAEEEARRRIEEEKKAFAEARRNMVVDD 355
+LK EE+ER+R E ++++K E+ ++ K F ++ +++
Sbjct: 374 -----------RLK---EEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEE 419
Query: 356 DSPEMYKTISQ 366
+ + K++ +
Sbjct: 420 RAEFLNKSVQK 430
Score = 54.3 bits (129), Expect = 4e-07
Identities = 61/288 (21%), Positives = 134/288 (46%), Gaps = 17/288 (5%)
Query: 316 EMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLE 375
E+ RQ+RE+ + +AE A +R +++++ A RR + + + S +T ++E
Sbjct: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT-DQVE 67
Query: 376 INFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQL-RQEMGEEEEENETFGLSREYEEL 434
+N + + +EE + T + + + E E+L R+E ++ E +E++
Sbjct: 68 VNAQNSVP---DEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 435 IKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDD 494
I S S+ ++ +++ +E E +K E+ +R+ ++E E +++ + D
Sbjct: 125 I-TDASLSLPSRRMQN------DTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDW 177
Query: 495 VDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIE--EQKLL--RMQFEQREIDAA 550
D +K + + K + + + + EE+ +++ +KL + F++ EI
Sbjct: 178 RDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE 237
Query: 551 LQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEP 598
KK +E +EE S M+ E ++++G + LK+T S P
Sbjct: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNG-EFMTHKLKHTENTFSRP 284
Score = 50.4 bits (119), Expect = 5e-06
Identities = 63/292 (21%), Positives = 124/292 (42%), Gaps = 54/292 (18%)
Query: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREER----------NQRRSRDEK 54
S++ + ++ V K+Y + ++K E ++ EE NQ + K
Sbjct: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTK 214
Query: 55 QRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQ 114
+ K + ++E + +K+EIK DE+ K K V KG F E++ Q
Sbjct: 215 VQAKREKLQEDKPTFKKEEIK------DEKIKKDKEPKEEVKSFMDRKKG-FTEVKSQNG 267
Query: 115 E---EQRKRTEEERKRRIEQDMLEKRKIQ-RELAKRAEQIEDINNTGTESASEEGDDSLL 170
E + K TE R + ++ ++ + + +++E++ E+ SEE +
Sbjct: 268 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE---- 323
Query: 171 ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMD 230
K + + E+L+K+REE+ ++ EE++R + EE D
Sbjct: 324 ------KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE--------------AD 363
Query: 231 DEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFE 282
++ E +K L EE+ER+R E +K+ ++ L ++K+ F+
Sbjct: 364 RKLREEEEKRRLK--------EEIERRRAEAAEKR-QKMPEDGLSDDKKPFK 406
Score = 41.6 bits (96), Expect = 0.002
Identities = 59/260 (22%), Positives = 108/260 (41%), Gaps = 43/260 (16%)
Query: 386 MEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEE-----------NETFGLSREYEEL 434
M++ +RR E R+ + EM + E E++ + +++EE E +E E L
Sbjct: 1 MDDFERRRELRRQKREEM-RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
Query: 435 IKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEE---ERARRRAIDLEIKEREAENFHE 491
++ + A+N E + +++ E ER RR + + +EA +
Sbjct: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
Query: 492 EDDVDVRPARKSEAPFTHKVNMKAR---FEQMAKAREEEEQRRIEEQKLLRMQFEQ---R 545
E D + A S P N A E+ K+ +E+ IEE + + +++ R
Sbjct: 120 EFDPTITDASLS-LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
Query: 546 EIDAALQKKREEEEEEEGSIMNGSTAEDE------------EQTRSGAPWFKKPLKNTSV 593
+ + ++ +E+EEEEE GS E++ E+ + P FKK +
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKK----EEI 234
Query: 594 VDSEPVRFTVKVTGEPKPEI 613
D + +K EPK E+
Sbjct: 235 KDEK-----IKKDKEPKEEV 249
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/202 (22%), Positives = 83/202 (41%), Gaps = 33/202 (16%)
Query: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRE 64
SQ E + K T+ G+ V K EA + E +R E+ RR+
Sbjct: 264 SQNGEFMTHKLKHTENTFSRPGGRASVDTK-EAEGAPQVEAGKRL---EELRRRRGETES 319
Query: 65 REWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE 124
E+ + KQ+ +++ + ++E+ K+++EE+RK EEE
Sbjct: 320 EEFEKLKQK---------QQEAALELEEL-----------------KKKREERRKVLEEE 353
Query: 125 RKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSG- 183
+RR +++ K + + E + E+IE E + +D L P K + G
Sbjct: 354 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS 413
Query: 184 --KMKKNFEDLEKEREEKERIK 203
K+++ E L K ++ +K
Sbjct: 414 SLKIEERAEFLNKSVQKSSGVK 435
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 90.5 bits (223), Expect = 5e-18
Identities = 117/606 (19%), Positives = 260/606 (42%), Gaps = 81/606 (13%)
Query: 34 KFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEM---------------L 78
K + + ++ + EK++ K++ E+E + K KE+
Sbjct: 619 KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFF 678
Query: 79 ASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRK 138
SD+ ED+ +E LT K + + K + + K +ER + E+D ++K
Sbjct: 679 KSDETEDLFLNMEHE---SLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK-- 733
Query: 139 IQRELAKRAEQIEDIN----NTGTESASEEG-------DDSLLITVVPV--------KSY 179
+ E + R E+I+D+ N T+ SE ++S+ + +V K
Sbjct: 734 -ESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI 792
Query: 180 KTSG-KMKKNFEDLEKEREEKERIKYEEDKRIRYEE--QRPSLKEAKCLSLVMD-DEIES 235
K S K +K + EK+ E+ ER +E++K+I++E ++ L ++C+ + + D++ S
Sbjct: 793 KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYS 852
Query: 236 EAKKESLSPGKLKLTFEELER--QRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDE 293
++ G+ +++ R+++R+K + +++ E+E+ E + ++ +
Sbjct: 853 HHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 912
Query: 294 ENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVV 353
+ D ++ K + GK K E++++ + +K + I+EEKK + +V
Sbjct: 913 KQSDNSEYSKSEK-GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKK-------SSIV 964
Query: 354 DDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQ 413
D + + K +S + T + + K K +++ R +E KHK +++ +L+
Sbjct: 965 DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS 1024
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQ--------- 464
E + + + S + + K + +++ FE++ L + EI+
Sbjct: 1025 EADKPKPK------SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEK 1078
Query: 465 -KKIEEERAR-RRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
K+ E+ER R R ++L+IK++E + + R + T E+ K
Sbjct: 1079 IKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTK----EKQPK 1134
Query: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEG------SIMNGSTAEDEEQ 576
+ ++ + ++ + D +L + E E+ G S+++ +++ED
Sbjct: 1135 DAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCH 1194
Query: 577 TRSGAP 582
T P
Sbjct: 1195 TTVTTP 1200
Score = 76.6 bits (187), Expect = 7e-14
Identities = 140/676 (20%), Positives = 279/676 (41%), Gaps = 98/676 (14%)
Query: 11 LLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAR-----EERNQRRSRDEKQR---RKEQYI 62
+L S P+P K D ++ M R E+R + EK ++E+
Sbjct: 324 ILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAF 383
Query: 63 REREWNRRKQEIKEML----ASDDEEDVSSK---VEKAYVPKLTGT---VKGRFAEMEKQ 112
+ + +KQ+ +L S DEE + +K + +P+ + + K + +
Sbjct: 384 YPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEH 443
Query: 113 RQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLIT 172
+Q+ + KR + + + E L++ K +E + + +E EEG+ +
Sbjct: 444 KQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFS 503
Query: 173 VVPVKS----YKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCL-SL 227
S + ++GK K+ L +++ +K E K P E L
Sbjct: 504 PKDDTSLHLFHISTGKSPKHSCGLSEKQSTP--LKQEHTKTCL----SPGSSEMSLQPDL 557
Query: 228 VMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQ 287
V D ESE ES S K E+ + Q+ + + + A+ + E+ FE +
Sbjct: 558 VRYDNTESEFLPESSSVKSCKHK-EKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCT 616
Query: 288 MVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEA 347
+ D+E + K ++ + + +E+E ++ + + + + +E +R +E +++ + E
Sbjct: 617 LKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKE- 675
Query: 348 RRNMVVDDDSPEMYKTISQEFLT---PGKLEINF--EELLKQKMEEEKRRTEEER-KHKL 401
N D++ +++ + E LT KLE N ++ K+K ++R +EER K K
Sbjct: 676 --NFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK 733
Query: 402 EMEKQEFEQLRQEMGEEEEE-----------------NETFGLSREYEELIKLKRSGSIQ 444
E EK E+ +++ EE E E+ GL +E+ K+ I
Sbjct: 734 ESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI- 792
Query: 445 AKNLKSKFEKIGQLSEKEI----------QKKIE-EERARRRAIDL-----EIKERE--- 485
K K K EK Q+ EK+I +KKI+ E ++ + +DL +IKE++
Sbjct: 793 -KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLY 851
Query: 486 ---AENFHEEDD----------VDVRPARKSEAPFTHKVNMKARFEQMAKARE----EEE 528
E H+E + D R + + H + +A+++E E++
Sbjct: 852 SHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKK 911
Query: 529 QRRIEEQKLLRMQ-FEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTR---SGAPWF 584
++ + + + + + +E D L KK + ++E +I N ++E+++
Sbjct: 912 NKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQH 971
Query: 585 KKPLKNTSVVDSEPVR 600
+KPL EP++
Sbjct: 972 EKPLSLKEKTKDEPLK 987
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 90.5 bits (223), Expect = 5e-18
Identities = 117/606 (19%), Positives = 260/606 (42%), Gaps = 81/606 (13%)
Query: 34 KFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEM---------------L 78
K + + ++ + EK++ K++ E+E + K KE+
Sbjct: 642 KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFF 701
Query: 79 ASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRK 138
SD+ ED+ +E LT K + + K + + K +ER + E+D ++K
Sbjct: 702 KSDETEDLFLNMEHE---SLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK-- 756
Query: 139 IQRELAKRAEQIEDIN----NTGTESASEEG-------DDSLLITVVPV--------KSY 179
+ E + R E+I+D+ N T+ SE ++S+ + +V K
Sbjct: 757 -ESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI 815
Query: 180 KTSG-KMKKNFEDLEKEREEKERIKYEEDKRIRYEE--QRPSLKEAKCLSLVMD-DEIES 235
K S K +K + EK+ E+ ER +E++K+I++E ++ L ++C+ + + D++ S
Sbjct: 816 KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYS 875
Query: 236 EAKKESLSPGKLKLTFEELER--QRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDE 293
++ G+ +++ R+++R+K + +++ E+E+ E + ++ +
Sbjct: 876 HHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
Query: 294 ENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVV 353
+ D ++ K + GK K E++++ + +K + I+EEKK + +V
Sbjct: 936 KQSDNSEYSKSEK-GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKK-------SSIV 987
Query: 354 DDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQ 413
D + + K +S + T + + K K +++ R +E KHK +++ +L+
Sbjct: 988 DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS 1047
Query: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQ--------- 464
E + + + S + + K + +++ FE++ L + EI+
Sbjct: 1048 EADKPKPK------SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEK 1101
Query: 465 -KKIEEERAR-RRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
K+ E+ER R R ++L+IK++E + + R + T E+ K
Sbjct: 1102 IKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTK----EKQPK 1157
Query: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEG------SIMNGSTAEDEEQ 576
+ ++ + ++ + D +L + E E+ G S+++ +++ED
Sbjct: 1158 DAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCH 1217
Query: 577 TRSGAP 582
T P
Sbjct: 1218 TTVTTP 1223
Score = 76.6 bits (187), Expect = 7e-14
Identities = 140/676 (20%), Positives = 279/676 (41%), Gaps = 98/676 (14%)
Query: 11 LLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAR-----EERNQRRSRDEKQR---RKEQYI 62
+L S P+P K D ++ M R E+R + EK ++E+
Sbjct: 347 ILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAF 406
Query: 63 REREWNRRKQEIKEML----ASDDEEDVSSK---VEKAYVPKLTGT---VKGRFAEMEKQ 112
+ + +KQ+ +L S DEE + +K + +P+ + + K + +
Sbjct: 407 YPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEH 466
Query: 113 RQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLIT 172
+Q+ + KR + + + E L++ K +E + + +E EEG+ +
Sbjct: 467 KQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFS 526
Query: 173 VVPVKS----YKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCL-SL 227
S + ++GK K+ L +++ +K E K P E L
Sbjct: 527 PKDDTSLHLFHISTGKSPKHSCGLSEKQSTP--LKQEHTKTCL----SPGSSEMSLQPDL 580
Query: 228 VMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQ 287
V D ESE ES S K E+ + Q+ + + + A+ + E+ FE +
Sbjct: 581 VRYDNTESEFLPESSSVKSCKHK-EKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCT 639
Query: 288 MVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEA 347
+ D+E + K ++ + + +E+E ++ + + + + +E +R +E +++ + E
Sbjct: 640 LKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKE- 698
Query: 348 RRNMVVDDDSPEMYKTISQEFLT---PGKLEINF--EELLKQKMEEEKRRTEEER-KHKL 401
N D++ +++ + E LT KLE N ++ K+K ++R +EER K K
Sbjct: 699 --NFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK 756
Query: 402 EMEKQEFEQLRQEMGEEEEE-----------------NETFGLSREYEELIKLKRSGSIQ 444
E EK E+ +++ EE E E+ GL +E+ K+ I
Sbjct: 757 ESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI- 815
Query: 445 AKNLKSKFEKIGQLSEKEI----------QKKIE-EERARRRAIDL-----EIKERE--- 485
K K K EK Q+ EK+I +KKI+ E ++ + +DL +IKE++
Sbjct: 816 -KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLY 874
Query: 486 ---AENFHEEDD----------VDVRPARKSEAPFTHKVNMKARFEQMAKARE----EEE 528
E H+E + D R + + H + +A+++E E++
Sbjct: 875 SHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKK 934
Query: 529 QRRIEEQKLLRMQ-FEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTR---SGAPWF 584
++ + + + + + +E D L KK + ++E +I N ++E+++
Sbjct: 935 NKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQH 994
Query: 585 KKPLKNTSVVDSEPVR 600
+KPL EP++
Sbjct: 995 EKPLSLKEKTKDEPLK 1010
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.126 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,243,379
Number of Sequences: 37866
Number of extensions: 1464526
Number of successful extensions: 57138
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 708
Number of HSP's successfully gapped in prelim test: 1771
Number of HSP's that attempted gapping in prelim test: 11476
Number of HSP's gapped (non-prelim): 17094
length of query: 675
length of database: 18,247,518
effective HSP length: 109
effective length of query: 566
effective length of database: 14,120,124
effective search space: 7991990184
effective search space used: 7991990184
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.