Search of human proteins with 148539855

Search of human proteins with 148539855

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148539855 epidermal growth factor receptor pathway substrate
8-like protein 1 isoform b [Homo sapiens]
         (596 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148539855 epidermal growth factor receptor pathway substrate ...  1199   0.0  
gi|148539853 epidermal growth factor receptor pathway substrate ...  1163   0.0  
gi|21264616 epidermal growth factor receptor pathway substrate 8...   347   2e-95
gi|56682953 epidermal growth factor receptor pathway substrate 8...   345   7e-95
gi|21071018 epidermal growth factor receptor pathway substrate 8...   177   3e-44
gi|21071016 epidermal growth factor receptor pathway substrate 8...   176   4e-44
gi|21071014 epidermal growth factor receptor pathway substrate 8...   168   1e-41
gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens]             53   7e-07
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]             53   7e-07
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]             53   7e-07
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]    52   1e-06
gi|5453754 NCK adaptor protein 1 [Homo sapiens]                        50   8e-06
gi|130977759 tec protein tyrosine kinase [Homo sapiens]                47   5e-05
gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens]      47   5e-05
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...    45   2e-04
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...    45   2e-04
gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]                   45   2e-04
gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]                   45   2e-04
gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]                   45   2e-04
gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]                    45   2e-04
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                 44   3e-04
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]      44   6e-04
gi|224177511 sorting nexin 18 isoform c [Homo sapiens]                 43   0.001
gi|157057545 sorting nexin 18 isoform a [Homo sapiens]                 43   0.001
gi|157057543 sorting nexin 18 isoform b [Homo sapiens]                 43   0.001
gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens]    43   0.001
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]               42   0.001
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                  42   0.002
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]            42   0.002
gi|187761324 shootin1 isoform a [Homo sapiens]                         42   0.002

>gi|148539855 epidermal growth factor receptor pathway substrate
           8-like protein 1 isoform b [Homo sapiens]
          Length = 596

 Score = 1199 bits (3102), Expect = 0.0
 Identities = 596/596 (100%), Positives = 596/596 (100%)

Query: 1   MNRTWPRRIWGSSQDEAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAET 60
           MNRTWPRRIWGSSQDEAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAET
Sbjct: 1   MNRTWPRRIWGSSQDEAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAET 60

Query: 61  PPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGP 120
           PPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGP
Sbjct: 61  PPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGP 120

Query: 121 DLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLR 180
           DLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLR
Sbjct: 121 DLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLR 180

Query: 181 AKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFAS 240
           AKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFAS
Sbjct: 181 AKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFAS 240

Query: 241 SVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPP 300
           SVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPP
Sbjct: 241 SVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPP 300

Query: 301 VTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNY 360
           VTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNY
Sbjct: 301 VTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNY 360

Query: 361 DFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPA 420
           DFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPA
Sbjct: 361 DFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPA 420

Query: 421 RSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQA 480
           RSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQA
Sbjct: 421 RSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQA 480

Query: 481 RLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSL 540
           RLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSL
Sbjct: 481 RLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSL 540

Query: 541 QKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI 596
           QKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI
Sbjct: 541 QKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI 596


>gi|148539853 epidermal growth factor receptor pathway substrate
           8-like protein 1 isoform a [Homo sapiens]
          Length = 723

 Score = 1163 bits (3008), Expect = 0.0
 Identities = 580/580 (100%), Positives = 580/580 (100%)

Query: 17  AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTV 76
           AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTV
Sbjct: 144 AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTV 203

Query: 77  ERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNH 136
           ERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNH
Sbjct: 204 ERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNH 263

Query: 137 VFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKI 196
           VFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKI
Sbjct: 264 VFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKI 323

Query: 197 KYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALLR 256
           KYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALLR
Sbjct: 324 KYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALLR 383

Query: 257 DNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQ 316
           DNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQ
Sbjct: 384 DNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQ 443

Query: 317 LQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRD 376
           LQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRD
Sbjct: 444 LQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRD 503

Query: 377 VLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPA 436
           VLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPA
Sbjct: 504 VLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPA 563

Query: 437 PPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQARLAQGRSGPSRAVPGP 496
           PPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQARLAQGRSGPSRAVPGP
Sbjct: 564 PPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQARLAQGRSGPSRAVPGP 623

Query: 497 RAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARV 556
           RAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARV
Sbjct: 624 RAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARV 683

Query: 557 YSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI 596
           YSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI
Sbjct: 684 YSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI 723


>gi|21264616 epidermal growth factor receptor pathway substrate
           8-like protein 2 [Homo sapiens]
          Length = 715

 Score =  347 bits (889), Expect = 2e-95
 Identities = 234/586 (39%), Positives = 318/586 (54%), Gaps = 60/586 (10%)

Query: 16  EAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVIST 75
           EAEL+ EDI+ AL + R G+ + R   L+  QE++++ +S     PP    P   A I  
Sbjct: 159 EAELVHEDIESALADCRLGK-KMRPQTLKGHQEKIRQRQSIL---PP----PQGPAPIPF 210

Query: 76  VERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILN 135
             RG           PEA+    P+   +            PR   +   + E+E  ILN
Sbjct: 211 QHRGGDS--------PEAKNRVGPQVPLSEPGFRRRESQEEPRA--VLAQKIEKETQILN 260

Query: 136 HVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQK 195
              DD+E FV+RLQK+AEA + L  R++G++  ++A  EG+LTLRA+PPSE E+ D  QK
Sbjct: 261 CALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQK 320

Query: 196 IKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALL 255
           IK A +LLA+L+ +I +PS+ EL+HFLFGPL +IVNT  GP+ A SV  P L+ DAV  L
Sbjct: 321 IKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFL 380

Query: 256 RDNVTPRENELWTSLGDSWTRPGLELSPE-EGPPYRPEFFSGWEPPVTDPQSRAWE---- 310
           R ++ P+E  LW SLG+SW RP  E   E + P Y P+F SGWEPPV   Q   WE    
Sbjct: 381 RGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGL 440

Query: 311 --DPVEKQLQHER---RRRQQSAPQVAVNGHRD-LEPESEPQLE-----SETAGKWVLCN 359
              P+E+     R   R  Q+ +P        D L P S P        +    K+V   
Sbjct: 441 ASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKIL 500

Query: 360 YDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSP 419
           YDF ARN++ELSV + +VLEVL+D R+WWK+R  +GQ GYVP NIL      R   + +P
Sbjct: 501 YDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGE---ARPEDAGAP 557

Query: 420 ARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQ-MLIVNEEL 478
                     P +P    PP+                     P  K++  Q M  VN+EL
Sbjct: 558 FEQAGQKYWGPASPTHKLPPSF--------------------PGNKDELMQHMDEVNDEL 597

Query: 479 QARLAQGRSGPSR--AVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQ 536
             +++  R+ P R   V   +     L+  S   EVRAWL+AK FS   V+ LG+LTG Q
Sbjct: 598 IRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQ 657

Query: 537 LFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEK 582
           LFSL KEEL+ V  EEG RVYSQ+T+Q++ LE ++  SELE +M K
Sbjct: 658 LFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNK 703


>gi|56682953 epidermal growth factor receptor pathway substrate 8
           [Homo sapiens]
          Length = 822

 Score =  345 bits (885), Expect = 7e-95
 Identities = 229/654 (35%), Positives = 339/654 (51%), Gaps = 103/654 (15%)

Query: 16  EAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVIST 75
           +A LI EDI+ A+ + + G+ +RR  ALR        +  P+   PP    P+    ++ 
Sbjct: 172 KANLISEDIESAISDSKGGKQKRRPDALRMIS-----NADPSIPPPPRAPAPAPPGTVTQ 226

Query: 76  VERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILN 135
           V+    R R  A     A++    +P       ++         P++   + +R+V ILN
Sbjct: 227 VDV---RSRVAAWSAWAADQGDFEKPRQYHEQEET---------PEMMAARIDRDVQILN 274

Query: 136 HVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQK 195
           H+ DD+E F+++LQK+AEA   L  R++ ++ +R+  GEG+LTLRAKPP   E+ D  QK
Sbjct: 275 HILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQK 334

Query: 196 IKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALL 255
            K+ F+LLA+L+ +I +PS+ +L+HFLF PL M+V  +GGPE ASSV  P L  D +  L
Sbjct: 335 FKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVVQATGGPELASSVLSPLLNKDTIDFL 394

Query: 256 RDNVTPRENELWTSLGDSWTRPGLELSPEEG-PPYRPEFFSGWEPPVTDPQSRAWE---- 310
              V   E +LW SLG +W +   E   E+  PPY P F +GWEPP+ +      E    
Sbjct: 395 NYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQDLY 454

Query: 311 ---DPVEKQLQHERRR-----------------------------------RQQSAPQVA 332
              + V    +H+R++                                   + ++A    
Sbjct: 455 QLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFK 514

Query: 333 VNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRD 392
              +R ++   EP L+++   K+    YDF ARN+SELSV + D+LE+LDD ++WWKVR+
Sbjct: 515 PTSNRHIDRNYEP-LKTQPK-KYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRN 572

Query: 393 PAGQEGYVPYNIL--------------TPY----PGPRLHHSQSPARSLNS-TPPPPPAP 433
            +G  G+VP NIL               PY       R+ +   PA +  + +PPP PAP
Sbjct: 573 ASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAP 632

Query: 434 APAP-PPALARP--------RWDRPRWDSCDSLNGLD---------PSEKEKFSQMLIVN 475
            P P PP+   P           R    S DS   +          P ++ K SQM  V 
Sbjct: 633 VPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRK-SQMEEVQ 691

Query: 476 EELQARLAQGRSGPSRA--VPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLT 533
           +EL  RL  GRS   +   VP    P   ++  S   +V+ WLQ+KGF+  TV++LGVL 
Sbjct: 692 DELIHRLTIGRSAAQKKFHVPRQNVPVINITYDSTPEDVKTWLQSKGFNPVTVNSLGVLN 751

Query: 534 GAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKV 587
           GAQLFSL K+ELR V P EGARVYSQ+TVQ++ LED    SEL+ +M ++++K+
Sbjct: 752 GAQLFSLNKDELRTVCP-EGARVYSQITVQKAALEDSSGSSELQEIMRRRQEKI 804


>gi|21071018 epidermal growth factor receptor pathway substrate
           8-like protein 3 isoform a [Homo sapiens]
          Length = 594

 Score =  177 bits (448), Expect = 3e-44
 Identities = 134/421 (31%), Positives = 208/421 (49%), Gaps = 50/421 (11%)

Query: 17  AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETP-PLQRR-------PS 68
           AE ++  +Q AL        E+    L   Q    R R PA E P P+++        P 
Sbjct: 136 AERLKTSLQKALEEEL----EQSRPRLGGLQPGQDRWRGPAMERPLPMEQARYLEPGIPP 191

Query: 69  VRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAE 128
            +    T+E       P  +P+P    A+ P          S+SP+             E
Sbjct: 192 EQPHQRTLEHSLP---PSPRPLPRHTSAREPSAFTLPPPRRSSSPE-----------DPE 237

Query: 129 REVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAE 188
           R+ ++LNHV  D+E F+ +L+K+   A+    ++ G++++     +G LT       +A+
Sbjct: 238 RDEEVLNHVLRDIELFMGKLEKAQ--AKTSRKKKFGKKNK----DQGGLT-------QAQ 284

Query: 189 YTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLT 248
           Y D  QKIK++F+LL RL   + + S+PEL+H LF  L  I+        A+ V  P LT
Sbjct: 285 YIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLT 344

Query: 249 SDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRA 308
             A+ LL+  ++P E+ LW  LG +WT    + + +E  PY+P F   W+ P  +P S+A
Sbjct: 345 PKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLP--EPSSQA 402

Query: 309 ---WEDPVEKQLQHERRRRQQSAPQVAVNGH--RDLEPESEPQ--LESETAGKWVLCNYD 361
              ++DPV  +    R       PQ   + H  +  +P S P     ++ A K  +  Y+
Sbjct: 403 PLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVL-YE 461

Query: 362 FQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTP-YPGPRLHHSQSPA 420
           F+ARN  EL+V Q + LEVLD S++WW V++ AG+ GY+P NIL P  PG      QSP+
Sbjct: 462 FEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPS 521

Query: 421 R 421
           R
Sbjct: 522 R 522



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 54/180 (30%), Positives = 80/180 (44%), Gaps = 34/180 (18%)

Query: 408 YPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWD----RPRWDSC---DSLNGL 460
           +P  + H+        NS P    +P PA P    +  ++     PR  +    + L  L
Sbjct: 425 FPQEKTHNHDPQPGDPNSRPS---SPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 481

Query: 461 DPSEKEKFSQMLIVNEELQARLAQGRSG--PSRAV-------PGPRAPEPQLSP----GS 507
           D S++      L+ NE        GRSG  PS  +       PG +   P   P     S
Sbjct: 482 DHSKR----WWLVKNEA-------GRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSS 530

Query: 508 DASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLL 567
              EV  WLQA+ FS+ TV  LG LTG+QL  ++  EL+ + P+E  R+ S++   R +L
Sbjct: 531 RPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 590


>gi|21071016 epidermal growth factor receptor pathway substrate
           8-like protein 3 isoform b [Homo sapiens]
          Length = 593

 Score =  176 bits (447), Expect = 4e-44
 Identities = 135/421 (32%), Positives = 210/421 (49%), Gaps = 51/421 (12%)

Query: 17  AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETP-PLQRR-------PS 68
           AE ++  +Q AL      R   R   L+  Q+   R R PA E P P+++        P 
Sbjct: 136 AERLKTSLQKALEEELEQRP--RLGGLQPGQD---RWRGPAMERPLPMEQARYLEPGIPP 190

Query: 69  VRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAE 128
            +    T+E       P  +P+P    A+ P          S+SP+             E
Sbjct: 191 EQPHQRTLEHSLP---PSPRPLPRHTSAREPSAFTLPPPRRSSSPE-----------DPE 236

Query: 129 REVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAE 188
           R+ ++LNHV  D+E F+ +L+K+   A+    ++ G++++     +G LT       +A+
Sbjct: 237 RDEEVLNHVLRDIELFMGKLEKAQ--AKTSRKKKFGKKNK----DQGGLT-------QAQ 283

Query: 189 YTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLT 248
           Y D  QKIK++F+LL RL   + + S+PEL+H LF  L  I+        A+ V  P LT
Sbjct: 284 YIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLT 343

Query: 249 SDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRA 308
             A+ LL+  ++P E+ LW  LG +WT    + + +E  PY+P F   W+ P  +P S+A
Sbjct: 344 PKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLP--EPSSQA 401

Query: 309 ---WEDPVEKQLQHERRRRQQSAPQVAVNGH--RDLEPESEPQ--LESETAGKWVLCNYD 361
              ++DPV  +    R       PQ   + H  +  +P S P     ++ A K  +  Y+
Sbjct: 402 PLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVL-YE 460

Query: 362 FQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTP-YPGPRLHHSQSPA 420
           F+ARN  EL+V Q + LEVLD S++WW V++ AG+ GY+P NIL P  PG      QSP+
Sbjct: 461 FEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPS 520

Query: 421 R 421
           R
Sbjct: 521 R 521



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 54/180 (30%), Positives = 80/180 (44%), Gaps = 34/180 (18%)

Query: 408 YPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWD----RPRWDSC---DSLNGL 460
           +P  + H+        NS P    +P PA P    +  ++     PR  +    + L  L
Sbjct: 424 FPQEKTHNHDPQPGDPNSRPS---SPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 480

Query: 461 DPSEKEKFSQMLIVNEELQARLAQGRSG--PSRAV-------PGPRAPEPQLSP----GS 507
           D S++      L+ NE        GRSG  PS  +       PG +   P   P     S
Sbjct: 481 DHSKR----WWLVKNEA-------GRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSS 529

Query: 508 DASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLL 567
              EV  WLQA+ FS+ TV  LG LTG+QL  ++  EL+ + P+E  R+ S++   R +L
Sbjct: 530 RPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 589


>gi|21071014 epidermal growth factor receptor pathway substrate
           8-like protein 3 isoform c [Homo sapiens]
          Length = 563

 Score =  168 bits (426), Expect = 1e-41
 Identities = 131/417 (31%), Positives = 205/417 (49%), Gaps = 73/417 (17%)

Query: 17  AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETP-PLQRR-------PS 68
           AE ++  +Q AL      R   R   L+  Q+   R R PA E P P+++        P 
Sbjct: 136 AERLKTSLQKALEEELEQRP--RLGGLQPGQD---RWRGPAMERPLPMEQARYLEPGIPP 190

Query: 69  VRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAE 128
            +    T+E       P  +P+P    A+ P          S+SP+             E
Sbjct: 191 EQPHQRTLEHSLP---PSPRPLPRHTSAREPSAFTLPPPRRSSSPE-----------DPE 236

Query: 129 REVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAE 188
           R+ ++LNHV  D+E F+ +L+K+   A+    ++ G++++     +G LT       +A+
Sbjct: 237 RDEEVLNHVLRDIELFMGKLEKAQ--AKTSRKKKFGKKNK----DQGGLT-------QAQ 283

Query: 189 YTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLT 248
           Y D  QKIK++F+LL RL   + + S+PEL+H LF  L  I+        A+ V  P LT
Sbjct: 284 YIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLT 343

Query: 249 SDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRA 308
             A+ LL+  ++P E+ LW  LG +WT    + + +E  PY+P F   W+ P  +P S+A
Sbjct: 344 PKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLP--EPSSQA 401

Query: 309 ---WEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQAR 365
              ++DPV           + S+P+ A           +P L+ +         Y+F+AR
Sbjct: 402 PLGYQDPVS---------LRPSSPKPA-----------QPALKMQVL-------YEFEAR 434

Query: 366 NSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTP-YPGPRLHHSQSPAR 421
           N  EL+V Q + LEVLD S++WW V++ AG+ GY+P NIL P  PG      QSP+R
Sbjct: 435 NPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSR 491



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 53/172 (30%), Positives = 78/172 (45%), Gaps = 31/172 (18%)

Query: 416 SQSPARSLNSTPPPPPAPAPAPPPALARPRWD----RPRWDSC---DSLNGLDPSEKEKF 468
           SQ+P    +     P +P PA P    +  ++     PR  +    + L  LD S++   
Sbjct: 399 SQAPLGYQDPVSLRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKR--- 455

Query: 469 SQMLIVNEELQARLAQGRSG--PSRAV-------PGPRAPEPQLSP----GSDASEVRAW 515
              L+ NE        GRSG  PS  +       PG +   P   P     S   EV  W
Sbjct: 456 -WWLVKNEA-------GRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDW 507

Query: 516 LQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLL 567
           LQA+ FS+ TV  LG LTG+QL  ++  EL+ + P+E  R+ S++   R +L
Sbjct: 508 LQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 559


>gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens]
          Length = 83

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 21/48 (43%), Positives = 33/48 (68%)

Query: 356 VLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYN 403
           V+  +D+ A+   EL +K+ + L +LDDS+ WW+VR+ A + GYVP N
Sbjct: 7   VIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSN 54


>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 21/48 (43%), Positives = 33/48 (68%)

Query: 356 VLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYN 403
           V+  +D+ A+   EL +K+ + L +LDDS+ WW+VR+ A + GYVP N
Sbjct: 7   VIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSN 54



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 20/64 (31%), Positives = 36/64 (56%), Gaps = 4/64 (6%)

Query: 360 YDFQARNSSELSVKQRDVLEVLD---DSRKWWKVRDPAGQEGYVPYN-ILTPYPGPRLHH 415
           Y F +    EL+ ++ + +EV++   +  +WWK ++  GQ G VP N ++    GP LH 
Sbjct: 204 YPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHP 263

Query: 416 SQSP 419
           + +P
Sbjct: 264 AHAP 267


>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 21/48 (43%), Positives = 33/48 (68%)

Query: 356 VLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYN 403
           V+  +D+ A+   EL +K+ + L +LDDS+ WW+VR+ A + GYVP N
Sbjct: 7   VIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSN 54



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 20/64 (31%), Positives = 36/64 (56%), Gaps = 4/64 (6%)

Query: 360 YDFQARNSSELSVKQRDVLEVLD---DSRKWWKVRDPAGQEGYVPYN-ILTPYPGPRLHH 415
           Y F +    EL+ ++ + +EV++   +  +WWK ++  GQ G VP N ++    GP LH 
Sbjct: 204 YPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHP 263

Query: 416 SQSP 419
           + +P
Sbjct: 264 AHAP 267


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 26/68 (38%), Positives = 41/68 (60%), Gaps = 3/68 (4%)

Query: 340 EPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSR-KWWKVRDPAGQEG 398
           EP + P   SE   K V+  YD+   N+++L +++ D   +L++S   WW+ RD  GQEG
Sbjct: 205 EPAAAPVSTSEL--KKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEG 262

Query: 399 YVPYNILT 406
           Y+P N +T
Sbjct: 263 YIPSNYVT 270


>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
          Length = 377

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 19/48 (39%), Positives = 32/48 (66%)

Query: 356 VLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYN 403
           V+  +D+ A+   EL +K+ + L +LDDS+ WW+VR+   + G+VP N
Sbjct: 7   VVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSN 54



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 18/50 (36%), Positives = 29/50 (58%), Gaps = 3/50 (6%)

Query: 360 YDFQARNSSELSVKQRDVLEVLD---DSRKWWKVRDPAGQEGYVPYNILT 406
           Y F + N  EL+ ++ DV++V++   +  +WWK R   G  G VP N +T
Sbjct: 199 YPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVT 248


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 1/85 (1%)

Query: 341 PESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSR-KWWKVRDPAGQEGY 399
           P   P  E + + + V+  YDFQA    +L +++     +L+ +   WW+ RD  G EGY
Sbjct: 169 PPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGY 228

Query: 400 VPYNILTPYPGPRLHHSQSPARSLN 424
           +P N +T      L   +   R++N
Sbjct: 229 IPSNYVTGKKSNNLDQYEWYCRNMN 253


>gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens]
          Length = 525

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 48/186 (25%), Positives = 79/186 (42%), Gaps = 32/186 (17%)

Query: 237 EFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRP------------GLELSPE 284
           +FA+ VR         A++++   P+  E   SL   W+               ++   E
Sbjct: 88  DFATEVR---------AVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKE 138

Query: 285 EG---PPYRPEFFSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEP 341
           EG   PP   +  S      T       ++ + K ++   + ++Q   +      + L P
Sbjct: 139 EGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTET-----KSLYP 193

Query: 342 ESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDS-RKWWKVRDPAGQEGYV 400
            SE QL ++ A K V   YDF+A   +EL+ K  +++ VLDDS   WWK  +  G  G  
Sbjct: 194 SSEIQLNNKVARK-VRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRG-IGLF 251

Query: 401 PYNILT 406
           P N +T
Sbjct: 252 PSNFVT 257


>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 2 [Homo sapiens]
          Length = 2472

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 6/109 (5%)

Query: 298  EPPVTDPQSRAWEDPVEKQLQ-HERRRRQQSAPQVAVNGHRDLEPESEPQL---ESETAG 353
            EP V        ED  E  L+ HE      SA   ++   R+       Q+   + ET  
Sbjct: 910  EPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969

Query: 354  KWVLCNYDFQARNSSELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVP 401
            + VL  YD+Q ++  E+++K+ D+L +L+ + K WWKV +   ++G+VP
Sbjct: 970  ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVP 1017


>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 1 [Homo sapiens]
          Length = 2477

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 6/109 (5%)

Query: 298  EPPVTDPQSRAWEDPVEKQLQ-HERRRRQQSAPQVAVNGHRDLEPESEPQL---ESETAG 353
            EP V        ED  E  L+ HE      SA   ++   R+       Q+   + ET  
Sbjct: 910  EPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969

Query: 354  KWVLCNYDFQARNSSELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVP 401
            + VL  YD+Q ++  E+++K+ D+L +L+ + K WWKV +   ++G+VP
Sbjct: 970  ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVP 1017


>gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]
          Length = 614

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 10/102 (9%)

Query: 312 PVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESET----AGKWVLCNYDFQARNS 367
           P E++ + E    + S  +       D E E E + E+E+     G+  +   DF A+  
Sbjct: 52  PTEEEEESESEDSEDSGGE-----EEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 106

Query: 368 SELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVPYNILTPY 408
            +L+ K+ ++L V++     WW  +D  G EG VP   L PY
Sbjct: 107 GDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 148


>gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]
          Length = 677

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 10/102 (9%)

Query: 312 PVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESET----AGKWVLCNYDFQARNS 367
           P E++ + E    + S  +       D E E E + E+E+     G+  +   DF A+  
Sbjct: 114 PTEEEEESESEDSEDSGGE-----EEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 168

Query: 368 SELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVPYNILTPY 408
            +L+ K+ ++L V++     WW  +D  G EG VP   L PY
Sbjct: 169 GDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210


>gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]
          Length = 732

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 10/102 (9%)

Query: 312 PVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESET----AGKWVLCNYDFQARNS 367
           P E++ + E    + S  +       D E E E + E+E+     G+  +   DF A+  
Sbjct: 114 PTEEEEESESEDSEDSGGE-----EEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 168

Query: 368 SELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVPYNILTPY 408
            +L+ K+ ++L V++     WW  +D  G EG VP   L PY
Sbjct: 169 GDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210


>gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]
          Length = 733

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 10/102 (9%)

Query: 312 PVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESET----AGKWVLCNYDFQARNS 367
           P E++ + E    + S  +       D E E E + E+E+     G+  +   DF A+  
Sbjct: 114 PTEEEEESESEDSEDSGGE-----EEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 168

Query: 368 SELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVPYNILTPY 408
            +L+ K+ ++L V++     WW  +D  G EG VP   L PY
Sbjct: 169 GDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 20/51 (39%), Positives = 32/51 (62%), Gaps = 1/51 (1%)

Query: 356 VLCNYDFQARNSSELSVKQRDVLEVLDDSR-KWWKVRDPAGQEGYVPYNIL 405
           V+  YD+Q  +  EL++++ +   +LD S   WW+V+D  G EGYVP + L
Sbjct: 176 VIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYL 226


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 20/49 (40%), Positives = 33/49 (67%), Gaps = 1/49 (2%)

Query: 356 VLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPA-GQEGYVPYN 403
           V+  YD++A +  +LS ++ D + VL++S +WWK R  A  +EGY+P N
Sbjct: 83  VVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSN 131


>gi|224177511 sorting nexin 18 isoform c [Homo sapiens]
          Length = 591

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 30/92 (32%), Positives = 43/92 (46%), Gaps = 8/92 (8%)

Query: 360 YDFQARNSSELSVKQRDVLEVL--DDSRKWWKVRDPAGQEGYVPYN----ILTPYPGPRL 413
           YDF++ N  E+S+++ +VL +    D   W +  +  G  G  P +    I  P PGP  
Sbjct: 9   YDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAG 68

Query: 414 HHSQ-SPARSLNSTPPPPPAPAPAPPPALARP 444
                +PAR  N  PP    P P  PPA  +P
Sbjct: 69  DGGPGAPARYAN-VPPGGFEPLPVAPPASFKP 99


>gi|157057545 sorting nexin 18 isoform a [Homo sapiens]
          Length = 624

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 30/92 (32%), Positives = 43/92 (46%), Gaps = 8/92 (8%)

Query: 360 YDFQARNSSELSVKQRDVLEVL--DDSRKWWKVRDPAGQEGYVPYN----ILTPYPGPRL 413
           YDF++ N  E+S+++ +VL +    D   W +  +  G  G  P +    I  P PGP  
Sbjct: 9   YDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAG 68

Query: 414 HHSQ-SPARSLNSTPPPPPAPAPAPPPALARP 444
                +PAR  N  PP    P P  PPA  +P
Sbjct: 69  DGGPGAPARYAN-VPPGGFEPLPVAPPASFKP 99


>gi|157057543 sorting nexin 18 isoform b [Homo sapiens]
          Length = 628

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 30/92 (32%), Positives = 43/92 (46%), Gaps = 8/92 (8%)

Query: 360 YDFQARNSSELSVKQRDVLEVL--DDSRKWWKVRDPAGQEGYVPYN----ILTPYPGPRL 413
           YDF++ N  E+S+++ +VL +    D   W +  +  G  G  P +    I  P PGP  
Sbjct: 9   YDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAG 68

Query: 414 HHSQ-SPARSLNSTPPPPPAPAPAPPPALARP 444
                +PAR  N  PP    P P  PPA  +P
Sbjct: 69  DGGPGAPARYAN-VPPGGFEPLPVAPPASFKP 99


>gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens]
          Length = 1090

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 22/54 (40%), Positives = 32/54 (59%), Gaps = 5/54 (9%)

Query: 360  YDFQARNSSELSVKQRDVLEVL----DDSRKWWKVRDPAGQEGYVPYNILTPYP 409
            +D++A+NS ELS  + D L +L    +   +WW  R    +EGYVP N+L  YP
Sbjct: 1028 WDYEAQNSDELSFHEGDALTILRRKDESETEWWWAR-LGDREGYVPKNLLGLYP 1080


>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
          Length = 330

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 37/149 (24%), Positives = 59/149 (39%), Gaps = 17/149 (11%)

Query: 276 RPGLELSPEEGPPYRP--EFFSGWEPPVTDPQSRAWEDPVEKQ-LQHERRRRQQSAPQVA 332
           RP +     + PP  P  +     +PP   P  +  + P +++ LQH    +++    + 
Sbjct: 179 RPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLD 238

Query: 333 VN-GHRDLEPESEP-------------QLESETAGKWVLCNYDFQARNSSELSVKQRDVL 378
           +N GH      SE              QL++    +W    YDF+A    EL     +V+
Sbjct: 239 INDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVV 298

Query: 379 EVLDDSRKWWKVRDPAGQEGYVPYNILTP 407
           EVLD S   W       + G  P N + P
Sbjct: 299 EVLDSSNPSWWTGRLHNKLGLFPANYVAP 327



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 19/49 (38%), Positives = 28/49 (57%), Gaps = 1/49 (2%)

Query: 357 LCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNIL 405
           +  +DF A    ELS    DVL++L +  +W+K  +   QEGYVP N +
Sbjct: 4   VAKFDFTASGEDELSFHTGDVLKILSNQEEWFKA-ELGSQEGYVPKNFI 51


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 8/109 (7%)

Query: 298 EPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVL 357
           E P+ +     W  P++   Q    +     P + V  H    P  E   E +    +V+
Sbjct: 12  EKPIKEKDKGQWS-PLKVSAQD---KDAPPLPPLVVFNHLTPPPPDEHLDEDK---HFVV 64

Query: 358 CNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRD-PAGQEGYVPYNIL 405
             YD+ A N  +L + + + L+VL  +  WW  R    G+EGYVP N +
Sbjct: 65  ALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFV 113


>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
          Length = 2419

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 22/47 (46%), Positives = 31/47 (65%), Gaps = 2/47 (4%)

Query: 356  VLCNYDFQARNSSELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVP 401
            V+  YDFQAR+  E+++K+ DVL +L    K WWKV + A  +G VP
Sbjct: 982  VMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKV-EAADHQGIVP 1027


>gi|187761324 shootin1 isoform a [Homo sapiens]
          Length = 631

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 65/289 (22%), Positives = 109/289 (37%), Gaps = 61/289 (21%)

Query: 315 KQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQ 374
           +QL+ ER + QQ   ++            E QLE+ET  K +              ++KQ
Sbjct: 274 QQLEEERIQHQQKVKEL------------EEQLENETLHKEIH-------------NLKQ 308

Query: 375 RDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPA 434
           +  LE+L++ +K  +++    +E              R++ S+      NS PPPPP P 
Sbjct: 309 Q--LELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSE------NSVPPPPPPPP 360

Query: 435 PAPPP---------ALARPRWDRPRWDSCDSLNGLDPSEKEKFSQM-LIVNEELQARLAQ 484
           P PPP         ++ R R   P            P   E+ + +     EE+  R+ +
Sbjct: 361 PLPPPPPNPIRSLMSMIRKR-SHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKK 419

Query: 485 GRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEE 544
           G        P  +   P+  P S          +KG  S  VD L  + G    S     
Sbjct: 420 G----VHLRPVNQTARPKTKPES----------SKGCES-AVDELKGILGTLNKSTSSRS 464

Query: 545 LRAVSPEEGARVYSQVTVQRSLLEDKEKVSE--LEAVMEKQKKKVEGEV 591
           L+++ PE       ++  +R +  + +  S   + A  E +   V G V
Sbjct: 465 LKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVLGSV 513


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.130    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,553,328
Number of Sequences: 37866
Number of extensions: 1726546
Number of successful extensions: 23161
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 351
Number of HSP's successfully gapped in prelim test: 514
Number of HSP's that attempted gapping in prelim test: 15544
Number of HSP's gapped (non-prelim): 5727
length of query: 596
length of database: 18,247,518
effective HSP length: 108
effective length of query: 488
effective length of database: 14,157,990
effective search space: 6909099120
effective search space used: 6909099120
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.