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Search of human proteins with 148539853
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148539853 epidermal growth factor receptor pathway substrate
8-like protein 1 isoform a [Homo sapiens]
(723 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148539853 epidermal growth factor receptor pathway substrate ... 1448 0.0
gi|148539855 epidermal growth factor receptor pathway substrate ... 1163 0.0
gi|56682953 epidermal growth factor receptor pathway substrate 8... 463 e-130
gi|21264616 epidermal growth factor receptor pathway substrate 8... 457 e-128
gi|21071018 epidermal growth factor receptor pathway substrate 8... 251 2e-66
gi|21071016 epidermal growth factor receptor pathway substrate 8... 250 3e-66
gi|21071014 epidermal growth factor receptor pathway substrate 8... 242 8e-64
gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens] 53 9e-07
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 53 9e-07
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 53 9e-07
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 52 1e-06
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 50 1e-05
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 47 6e-05
gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens] 47 6e-05
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 45 2e-04
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 45 2e-04
gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens] 45 3e-04
gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens] 45 3e-04
gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens] 45 3e-04
gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens] 45 3e-04
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 44 4e-04
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 44 7e-04
gi|224177511 sorting nexin 18 isoform c [Homo sapiens] 43 0.001
gi|157057545 sorting nexin 18 isoform a [Homo sapiens] 43 0.001
gi|157057543 sorting nexin 18 isoform b [Homo sapiens] 43 0.001
gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens] 43 0.001
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 42 0.002
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 42 0.002
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 42 0.002
gi|187761324 shootin1 isoform a [Homo sapiens] 42 0.002
>gi|148539853 epidermal growth factor receptor pathway substrate
8-like protein 1 isoform a [Homo sapiens]
Length = 723
Score = 1448 bits (3748), Expect = 0.0
Identities = 723/723 (100%), Positives = 723/723 (100%)
Query: 1 MSTATGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYPVNHLVTFCLGEDDGVHTVEDASR 60
MSTATGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYPVNHLVTFCLGEDDGVHTVEDASR
Sbjct: 1 MSTATGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYPVNHLVTFCLGEDDGVHTVEDASR 60
Query: 61 KLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLL 120
KLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLL
Sbjct: 61 KLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLL 120
Query: 121 LLVCQEPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRD 180
LLVCQEPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRD
Sbjct: 121 LLVCQEPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRD 180
Query: 181 RSPAAETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASP 240
RSPAAETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASP
Sbjct: 181 RSPAAETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASP 240
Query: 241 DLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAG 300
DLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAG
Sbjct: 241 DLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAG 300
Query: 301 EGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTS 360
EGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTS
Sbjct: 301 EGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTS 360
Query: 361 GGPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEF 420
GGPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEF
Sbjct: 361 GGPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEF 420
Query: 421 FSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAG 480
FSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAG
Sbjct: 421 FSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAG 480
Query: 481 KWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRL 540
KWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRL
Sbjct: 481 KWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRL 540
Query: 541 HHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLI 600
HHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLI
Sbjct: 541 HHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLI 600
Query: 601 VNEELQARLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLT 660
VNEELQARLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLT
Sbjct: 601 VNEELQARLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLT 660
Query: 661 GAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEM 720
GAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEM
Sbjct: 661 GAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEM 720
Query: 721 EVI 723
EVI
Sbjct: 721 EVI 723
>gi|148539855 epidermal growth factor receptor pathway substrate
8-like protein 1 isoform b [Homo sapiens]
Length = 596
Score = 1163 bits (3008), Expect = 0.0
Identities = 580/580 (100%), Positives = 580/580 (100%)
Query: 144 AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTV 203
AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTV
Sbjct: 17 AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTV 76
Query: 204 ERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNH 263
ERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNH
Sbjct: 77 ERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNH 136
Query: 264 VFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKI 323
VFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKI
Sbjct: 137 VFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKI 196
Query: 324 KYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALLR 383
KYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALLR
Sbjct: 197 KYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALLR 256
Query: 384 DNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQ 443
DNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQ
Sbjct: 257 DNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQ 316
Query: 444 LQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRD 503
LQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRD
Sbjct: 317 LQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRD 376
Query: 504 VLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPA 563
VLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPA
Sbjct: 377 VLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPA 436
Query: 564 PPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQARLAQGRSGPSRAVPGP 623
PPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQARLAQGRSGPSRAVPGP
Sbjct: 437 PPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQARLAQGRSGPSRAVPGP 496
Query: 624 RAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARV 683
RAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARV
Sbjct: 497 RAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARV 556
Query: 684 YSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI 723
YSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI
Sbjct: 557 YSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI 596
>gi|56682953 epidermal growth factor receptor pathway substrate 8
[Homo sapiens]
Length = 822
Score = 463 bits (1191), Expect = e-130
Identities = 294/795 (36%), Positives = 428/795 (53%), Gaps = 106/795 (13%)
Query: 5 TGPEAAPKPSAKSIYEQRKRY---STVVMADVSQYPVNHLVTFCLGEDDGVHTVEDASRK 61
T E K SAK++YEQRK Y S ++D+SQY V HL TF L D + TV+D RK
Sbjct: 31 TDREHGSKTSAKALYEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRK 90
Query: 62 LAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLL 121
L ++D++G+VW Q+M+L+V V+L+D SK ELE++PL I C AVM S+L
Sbjct: 91 LKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLA 150
Query: 122 LVCQEPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDR 181
LVC+EP + +PD+H FQ + A LI EDI+ A+ + + G+ +RR ALR +
Sbjct: 151 LVCKEPTQNKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRRPDALRMIS-----NA 205
Query: 182 SPAAETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPD 241
P+ PP P+ ++ V+ R R A A++ +P ++
Sbjct: 206 DPSIPPPPRAPAPAPPGTVTQVDV---RSRVAAWSAWAADQGDFEKPRQYHEQEET---- 258
Query: 242 LGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGE 301
P++ + +R+V ILNH+ DD+E F+++LQK+AEA L R++ ++ +R+ GE
Sbjct: 259 -----PEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGE 313
Query: 302 GLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSG 361
G+LTLRAKPP E+ D QK K+ F+LLA+L+ +I +PS+ +L+HFLF PL M+V +G
Sbjct: 314 GVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVVQATG 373
Query: 362 GPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEG-PPYRPEF 420
GPE ASSV P L D + L V E +LW SLG +W + E E+ PPY P F
Sbjct: 374 GPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRF 433
Query: 421 FSGWEPPVTDPQSRAWE-------DPVEKQLQHERRR----------------------- 450
+GWEPP+ + E + V +H+R++
Sbjct: 434 RNGWEPPMLNFMGATMEQDLYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAF 493
Query: 451 ------------RQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELS 498
+ ++A +R ++ EP L+++ K+ YDF ARN+SELS
Sbjct: 494 SSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEP-LKTQPK-KYAKSKYDFVARNNSELS 551
Query: 499 VKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNIL--------------TPY----PGPRL 540
V + D+LE+LDD ++WWKVR+ +G G+VP NIL PY R+
Sbjct: 552 VLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRM 611
Query: 541 HHSQSPARSLNS-TPPPPPAPAPAP-PPALARP--------RWDRPRWDSCDSLNGLD-- 588
+ PA + + +PPP PAP P P PP+ P R S DS +
Sbjct: 612 EYGPRPADTPPAPSPPPTPAPVPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRD 671
Query: 589 -------PSEKEKFSQMLIVNEELQARLAQGRSGPSRA--VPGPRAPEPQLSPGSDASEV 639
P ++ K SQM V +EL RL GRS + VP P ++ S +V
Sbjct: 672 SQRHKQLPVDRRK-SQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINITYDSTPEDV 730
Query: 640 RAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEK 699
+ WLQ+KGF+ TV++LGVL GAQLFSL K+ELR V P EGARVYSQ+TVQ++ LED
Sbjct: 731 KTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCP-EGARVYSQITVQKAALEDSSG 789
Query: 700 VSELEAVMEKQKKKV 714
SEL+ +M ++++K+
Sbjct: 790 SSELQEIMRRRQEKI 804
>gi|21264616 epidermal growth factor receptor pathway substrate
8-like protein 2 [Homo sapiens]
Length = 715
Score = 457 bits (1177), Expect = e-128
Identities = 293/723 (40%), Positives = 406/723 (56%), Gaps = 62/723 (8%)
Query: 8 EAAPKPSAKSIYEQRKRYST--VVMADVSQYPVNHLVTFCLGEDDGVHTVEDASRKLAVM 65
+ K S K ++EQRK+YS V+M + SQY V HL TF + + + + +V+DA RKL +
Sbjct: 22 DGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQL 81
Query: 66 DSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQ 125
S+ ++W QEMLL+V+ + LLD S+EELE +PL + R V+ R S+LLLVCQ
Sbjct: 82 SSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQ 141
Query: 126 EPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAA 185
+ E+++PDVHFF + AEL+ EDI+ AL + R G+ + R L+ QE++++ +S
Sbjct: 142 DSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGK-KMRPQTLKGHQEKIRQRQSIL- 199
Query: 186 ETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPR 245
PP P A I RG PEA+ P+ + PR
Sbjct: 200 --PP----PQGPAPIPFQHRGGDS--------PEAKNRVGPQVPLSEPGFRRRESQEEPR 245
Query: 246 GPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLT 305
+ + E+E ILN DD+E FV+RLQK+AEA + L R++G++ ++A EG+LT
Sbjct: 246 A--VLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLT 303
Query: 306 LRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEF 365
LRA+PPSE E+ D QKIK A +LLA+L+ +I +PS+ EL+HFLFGPL +IVNT GP+
Sbjct: 304 LRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDI 363
Query: 366 ASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPE-EGPPYRPEFFSGW 424
A SV P L+ DAV LR ++ P+E LW SLG+SW RP E E + P Y P+F SGW
Sbjct: 364 ARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGW 423
Query: 425 EPPVTDPQSRAWE------DPVEKQLQHER---RRRQQSAPQVAVNGHRD-LEPESEPQL 474
EPPV Q WE P+E+ R R Q+ +P D L P S P
Sbjct: 424 EPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHT 483
Query: 475 E-----SETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPY 529
+ K+V YDF ARN++ELSV + +VLEVL+D R+WWK+R +GQ GYVP
Sbjct: 484 HRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPC 543
Query: 530 NILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDP 589
NIL R + +P P +P PP+ P
Sbjct: 544 NILGE---ARPEDAGAPFEQAGQKYWGPASPTHKLPPSF--------------------P 580
Query: 590 SEKEKFSQ-MLIVNEELQARLAQGRSGPSR--AVPGPRAPEPQLSPGSDASEVRAWLQAK 646
K++ Q M VN+EL +++ R+ P R V + L+ S EVRAWL+AK
Sbjct: 581 GNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAK 640
Query: 647 GFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAV 706
FS V+ LG+LTG QLFSL KEEL+ V EEG RVYSQ+T+Q++ LE ++ SELE +
Sbjct: 641 AFSPRIVENLGILTGPQLFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEEL 700
Query: 707 MEK 709
M K
Sbjct: 701 MNK 703
>gi|21071018 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform a [Homo sapiens]
Length = 594
Score = 251 bits (640), Expect = 2e-66
Identities = 183/555 (32%), Positives = 283/555 (50%), Gaps = 53/555 (9%)
Query: 12 KPSAKSIYEQRKRYSTVVMADVS--QYPVNHLVTFCLGEDDGVHTVEDASRKLAVMDSQG 69
+PS+++IY RK YS + ++ + Q+ V HL+T C V EDA +KL MD+QG
Sbjct: 3 RPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDAQG 61
Query: 70 RVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQEPER 129
RVW+Q+++L+V + LLD +KEEL+SY L +I + + S+L + QEP
Sbjct: 62 RVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPGL 121
Query: 130 AQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETP- 188
FQ +GAE ++ +Q AL E+ L Q R R PA E P
Sbjct: 122 PGTSTLLFQCQEVGAERLKTSLQKALEEEL----EQSRPRLGGLQPGQDRWRGPAMERPL 177
Query: 189 PLQRR-------PSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPD 241
P+++ P + T+E P +P+P A+ P S+SP+
Sbjct: 178 PMEQARYLEPGIPPEQPHQRTLEHSLP---PSPRPLPRHTSAREPSAFTLPPPRRSSSPE 234
Query: 242 LGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGE 301
ER+ ++LNHV D+E F+ +L+K+ A+ ++ G++++ +
Sbjct: 235 -----------DPERDEEVLNHVLRDIELFMGKLEKAQ--AKTSRKKKFGKKNK----DQ 277
Query: 302 GLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSG 361
G LT +A+Y D QKIK++F+LL RL + + S+PEL+H LF L I+
Sbjct: 278 GGLT-------QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCP 330
Query: 362 GPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFF 421
A+ V P LT A+ LL+ ++P E+ LW LG +WT + + +E PY+P F
Sbjct: 331 EAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFS 390
Query: 422 SGWEPPVTDPQSRA---WEDPVEKQLQHERRRRQQSAPQVAVNGH--RDLEPESEPQ--L 474
W+ P +P S+A ++DPV + R PQ + H + +P S P
Sbjct: 391 DDWQLP--EPSSQAPLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPK 448
Query: 475 ESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTP 534
++ A K + Y+F+ARN EL+V Q + LEVLD S++WW V++ AG+ GY+P NIL P
Sbjct: 449 PAQPALKMQVL-YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEP 507
Query: 535 -YPGPRLHHSQSPAR 548
PG QSP+R
Sbjct: 508 LQPGTPGTQGQSPSR 522
Score = 56.2 bits (134), Expect = 1e-07
Identities = 54/180 (30%), Positives = 80/180 (44%), Gaps = 34/180 (18%)
Query: 535 YPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWD----RPRWDSC---DSLNGL 587
+P + H+ NS P +P PA P + ++ PR + + L L
Sbjct: 425 FPQEKTHNHDPQPGDPNSRPS---SPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 481
Query: 588 DPSEKEKFSQMLIVNEELQARLAQGRSG--PSRAV-------PGPRAPEPQLSP----GS 634
D S++ L+ NE GRSG PS + PG + P P S
Sbjct: 482 DHSKR----WWLVKNEA-------GRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSS 530
Query: 635 DASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLL 694
EV WLQA+ FS+ TV LG LTG+QL ++ EL+ + P+E R+ S++ R +L
Sbjct: 531 RPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 590
>gi|21071016 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform b [Homo sapiens]
Length = 593
Score = 250 bits (639), Expect = 3e-66
Identities = 184/555 (33%), Positives = 285/555 (51%), Gaps = 54/555 (9%)
Query: 12 KPSAKSIYEQRKRYSTVVMADVS--QYPVNHLVTFCLGEDDGVHTVEDASRKLAVMDSQG 69
+PS+++IY RK YS + ++ + Q+ V HL+T C V EDA +KL MD+QG
Sbjct: 3 RPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDAQG 61
Query: 70 RVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQEPER 129
RVW+Q+++L+V + LLD +KEEL+SY L +I + + S+L + QEP
Sbjct: 62 RVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPGL 121
Query: 130 AQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETP- 188
FQ +GAE ++ +Q AL R R L+ Q+ R R PA E P
Sbjct: 122 PGTSTLLFQCQEVGAERLKTSLQKALEEELEQRP--RLGGLQPGQD---RWRGPAMERPL 176
Query: 189 PLQRR-------PSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPD 241
P+++ P + T+E P +P+P A+ P S+SP+
Sbjct: 177 PMEQARYLEPGIPPEQPHQRTLEHSLP---PSPRPLPRHTSAREPSAFTLPPPRRSSSPE 233
Query: 242 LGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGE 301
ER+ ++LNHV D+E F+ +L+K+ A+ ++ G++++ +
Sbjct: 234 -----------DPERDEEVLNHVLRDIELFMGKLEKAQ--AKTSRKKKFGKKNK----DQ 276
Query: 302 GLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSG 361
G LT +A+Y D QKIK++F+LL RL + + S+PEL+H LF L I+
Sbjct: 277 GGLT-------QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCP 329
Query: 362 GPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFF 421
A+ V P LT A+ LL+ ++P E+ LW LG +WT + + +E PY+P F
Sbjct: 330 EAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFS 389
Query: 422 SGWEPPVTDPQSRA---WEDPVEKQLQHERRRRQQSAPQVAVNGH--RDLEPESEPQ--L 474
W+ P +P S+A ++DPV + R PQ + H + +P S P
Sbjct: 390 DDWQLP--EPSSQAPLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPK 447
Query: 475 ESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTP 534
++ A K + Y+F+ARN EL+V Q + LEVLD S++WW V++ AG+ GY+P NIL P
Sbjct: 448 PAQPALKMQVL-YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEP 506
Query: 535 -YPGPRLHHSQSPAR 548
PG QSP+R
Sbjct: 507 LQPGTPGTQGQSPSR 521
Score = 56.2 bits (134), Expect = 1e-07
Identities = 54/180 (30%), Positives = 80/180 (44%), Gaps = 34/180 (18%)
Query: 535 YPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWD----RPRWDSC---DSLNGL 587
+P + H+ NS P +P PA P + ++ PR + + L L
Sbjct: 424 FPQEKTHNHDPQPGDPNSRPS---SPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 480
Query: 588 DPSEKEKFSQMLIVNEELQARLAQGRSG--PSRAV-------PGPRAPEPQLSP----GS 634
D S++ L+ NE GRSG PS + PG + P P S
Sbjct: 481 DHSKR----WWLVKNEA-------GRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSS 529
Query: 635 DASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLL 694
EV WLQA+ FS+ TV LG LTG+QL ++ EL+ + P+E R+ S++ R +L
Sbjct: 530 RPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 589
>gi|21071014 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform c [Homo sapiens]
Length = 563
Score = 242 bits (618), Expect = 8e-64
Identities = 180/551 (32%), Positives = 280/551 (50%), Gaps = 76/551 (13%)
Query: 12 KPSAKSIYEQRKRYSTVVMADVS--QYPVNHLVTFCLGEDDGVHTVEDASRKLAVMDSQG 69
+PS+++IY RK YS + ++ + Q+ V HL+T C V EDA +KL MD+QG
Sbjct: 3 RPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDAQG 61
Query: 70 RVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQEPER 129
RVW+Q+++L+V + LLD +KEEL+SY L +I + + S+L + QEP
Sbjct: 62 RVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPGL 121
Query: 130 AQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETP- 188
FQ +GAE ++ +Q AL R R L+ Q+ R R PA E P
Sbjct: 122 PGTSTLLFQCQEVGAERLKTSLQKALEEELEQRP--RLGGLQPGQD---RWRGPAMERPL 176
Query: 189 PLQRR-------PSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPD 241
P+++ P + T+E P +P+P A+ P S+SP+
Sbjct: 177 PMEQARYLEPGIPPEQPHQRTLEHSLP---PSPRPLPRHTSAREPSAFTLPPPRRSSSPE 233
Query: 242 LGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGE 301
ER+ ++LNHV D+E F+ +L+K+ A+ ++ G++++ +
Sbjct: 234 -----------DPERDEEVLNHVLRDIELFMGKLEKAQ--AKTSRKKKFGKKNK----DQ 276
Query: 302 GLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSG 361
G LT +A+Y D QKIK++F+LL RL + + S+PEL+H LF L I+
Sbjct: 277 GGLT-------QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCP 329
Query: 362 GPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFF 421
A+ V P LT A+ LL+ ++P E+ LW LG +WT + + +E PY+P F
Sbjct: 330 EAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFS 389
Query: 422 SGWEPPVTDPQSRA---WEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESET 478
W+ P +P S+A ++DPV + S+P+ A +P L+ +
Sbjct: 390 DDWQLP--EPSSQAPLGYQDPVS---------LRPSSPKPA-----------QPALKMQV 427
Query: 479 AGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTP-YPG 537
Y+F+ARN EL+V Q + LEVLD S++WW V++ AG+ GY+P NIL P PG
Sbjct: 428 L-------YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPG 480
Query: 538 PRLHHSQSPAR 548
QSP+R
Sbjct: 481 TPGTQGQSPSR 491
Score = 56.6 bits (135), Expect = 8e-08
Identities = 53/172 (30%), Positives = 78/172 (45%), Gaps = 31/172 (18%)
Query: 543 SQSPARSLNSTPPPPPAPAPAPPPALARPRWD----RPRWDSC---DSLNGLDPSEKEKF 595
SQ+P + P +P PA P + ++ PR + + L LD S++
Sbjct: 399 SQAPLGYQDPVSLRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKR--- 455
Query: 596 SQMLIVNEELQARLAQGRSG--PSRAV-------PGPRAPEPQLSP----GSDASEVRAW 642
L+ NE GRSG PS + PG + P P S EV W
Sbjct: 456 -WWLVKNEA-------GRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDW 507
Query: 643 LQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLL 694
LQA+ FS+ TV LG LTG+QL ++ EL+ + P+E R+ S++ R +L
Sbjct: 508 LQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 559
>gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens]
Length = 83
Score = 53.1 bits (126), Expect = 9e-07
Identities = 21/48 (43%), Positives = 33/48 (68%)
Query: 483 VLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYN 530
V+ +D+ A+ EL +K+ + L +LDDS+ WW+VR+ A + GYVP N
Sbjct: 7 VIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSN 54
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 53.1 bits (126), Expect = 9e-07
Identities = 21/48 (43%), Positives = 33/48 (68%)
Query: 483 VLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYN 530
V+ +D+ A+ EL +K+ + L +LDDS+ WW+VR+ A + GYVP N
Sbjct: 7 VIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSN 54
Score = 41.2 bits (95), Expect = 0.003
Identities = 20/64 (31%), Positives = 36/64 (56%), Gaps = 4/64 (6%)
Query: 487 YDFQARNSSELSVKQRDVLEVLD---DSRKWWKVRDPAGQEGYVPYN-ILTPYPGPRLHH 542
Y F + EL+ ++ + +EV++ + +WWK ++ GQ G VP N ++ GP LH
Sbjct: 204 YPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHP 263
Query: 543 SQSP 546
+ +P
Sbjct: 264 AHAP 267
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 53.1 bits (126), Expect = 9e-07
Identities = 21/48 (43%), Positives = 33/48 (68%)
Query: 483 VLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYN 530
V+ +D+ A+ EL +K+ + L +LDDS+ WW+VR+ A + GYVP N
Sbjct: 7 VIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSN 54
Score = 41.2 bits (95), Expect = 0.003
Identities = 20/64 (31%), Positives = 36/64 (56%), Gaps = 4/64 (6%)
Query: 487 YDFQARNSSELSVKQRDVLEVLD---DSRKWWKVRDPAGQEGYVPYN-ILTPYPGPRLHH 542
Y F + EL+ ++ + +EV++ + +WWK ++ GQ G VP N ++ GP LH
Sbjct: 204 YPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHP 263
Query: 543 SQSP 546
+ +P
Sbjct: 264 AHAP 267
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 52.4 bits (124), Expect = 1e-06
Identities = 26/68 (38%), Positives = 41/68 (60%), Gaps = 3/68 (4%)
Query: 467 EPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSR-KWWKVRDPAGQEG 525
EP + P SE K V+ YD+ N+++L +++ D +L++S WW+ RD GQEG
Sbjct: 205 EPAAAPVSTSEL--KKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEG 262
Query: 526 YVPYNILT 533
Y+P N +T
Sbjct: 263 YIPSNYVT 270
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 49.7 bits (117), Expect = 1e-05
Identities = 19/48 (39%), Positives = 32/48 (66%)
Query: 483 VLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYN 530
V+ +D+ A+ EL +K+ + L +LDDS+ WW+VR+ + G+VP N
Sbjct: 7 VVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSN 54
Score = 38.9 bits (89), Expect = 0.017
Identities = 18/50 (36%), Positives = 29/50 (58%), Gaps = 3/50 (6%)
Query: 487 YDFQARNSSELSVKQRDVLEVLD---DSRKWWKVRDPAGQEGYVPYNILT 533
Y F + N EL+ ++ DV++V++ + +WWK R G G VP N +T
Sbjct: 199 YPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVT 248
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 47.0 bits (110), Expect = 6e-05
Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 1/85 (1%)
Query: 468 PESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSR-KWWKVRDPAGQEGY 526
P P E + + + V+ YDFQA +L +++ +L+ + WW+ RD G EGY
Sbjct: 169 PPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGY 228
Query: 527 VPYNILTPYPGPRLHHSQSPARSLN 551
+P N +T L + R++N
Sbjct: 229 IPSNYVTGKKSNNLDQYEWYCRNMN 253
>gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens]
Length = 525
Score = 47.0 bits (110), Expect = 6e-05
Identities = 48/186 (25%), Positives = 79/186 (42%), Gaps = 32/186 (17%)
Query: 364 EFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRP------------GLELSPE 411
+FA+ VR A++++ P+ E SL W+ ++ E
Sbjct: 88 DFATEVR---------AVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKE 138
Query: 412 EG---PPYRPEFFSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEP 468
EG PP + S T ++ + K ++ + ++Q + + L P
Sbjct: 139 EGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTET-----KSLYP 193
Query: 469 ESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDS-RKWWKVRDPAGQEGYV 527
SE QL ++ A K V YDF+A +EL+ K +++ VLDDS WWK + G G
Sbjct: 194 SSEIQLNNKVARK-VRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRG-IGLF 251
Query: 528 PYNILT 533
P N +T
Sbjct: 252 PSNFVT 257
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 6/109 (5%)
Query: 425 EPPVTDPQSRAWEDPVEKQLQ-HERRRRQQSAPQVAVNGHRDLEPESEPQL---ESETAG 480
EP V ED E L+ HE SA ++ R+ Q+ + ET
Sbjct: 910 EPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
Query: 481 KWVLCNYDFQARNSSELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVP 528
+ VL YD+Q ++ E+++K+ D+L +L+ + K WWKV + ++G+VP
Sbjct: 970 ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVP 1017
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 6/109 (5%)
Query: 425 EPPVTDPQSRAWEDPVEKQLQ-HERRRRQQSAPQVAVNGHRDLEPESEPQL---ESETAG 480
EP V ED E L+ HE SA ++ R+ Q+ + ET
Sbjct: 910 EPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
Query: 481 KWVLCNYDFQARNSSELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVP 528
+ VL YD+Q ++ E+++K+ D+L +L+ + K WWKV + ++G+VP
Sbjct: 970 ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVP 1017
>gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]
Length = 614
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 10/102 (9%)
Query: 439 PVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESET----AGKWVLCNYDFQARNS 494
P E++ + E + S + D E E E + E+E+ G+ + DF A+
Sbjct: 52 PTEEEEESESEDSEDSGGE-----EEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 106
Query: 495 SELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVPYNILTPY 535
+L+ K+ ++L V++ WW +D G EG VP L PY
Sbjct: 107 GDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 148
>gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]
Length = 677
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 10/102 (9%)
Query: 439 PVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESET----AGKWVLCNYDFQARNS 494
P E++ + E + S + D E E E + E+E+ G+ + DF A+
Sbjct: 114 PTEEEEESESEDSEDSGGE-----EEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 168
Query: 495 SELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVPYNILTPY 535
+L+ K+ ++L V++ WW +D G EG VP L PY
Sbjct: 169 GDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210
>gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]
Length = 732
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 10/102 (9%)
Query: 439 PVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESET----AGKWVLCNYDFQARNS 494
P E++ + E + S + D E E E + E+E+ G+ + DF A+
Sbjct: 114 PTEEEEESESEDSEDSGGE-----EEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 168
Query: 495 SELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVPYNILTPY 535
+L+ K+ ++L V++ WW +D G EG VP L PY
Sbjct: 169 GDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210
>gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]
Length = 733
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 10/102 (9%)
Query: 439 PVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESET----AGKWVLCNYDFQARNS 494
P E++ + E + S + D E E E + E+E+ G+ + DF A+
Sbjct: 114 PTEEEEESESEDSEDSGGE-----EEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 168
Query: 495 SELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVPYNILTPY 535
+L+ K+ ++L V++ WW +D G EG VP L PY
Sbjct: 169 GDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/51 (39%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 483 VLCNYDFQARNSSELSVKQRDVLEVLDDSR-KWWKVRDPAGQEGYVPYNIL 532
V+ YD+Q + EL++++ + +LD S WW+V+D G EGYVP + L
Sbjct: 176 VIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYL 226
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 43.5 bits (101), Expect = 7e-04
Identities = 20/49 (40%), Positives = 33/49 (67%), Gaps = 1/49 (2%)
Query: 483 VLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPA-GQEGYVPYN 530
V+ YD++A + +LS ++ D + VL++S +WWK R A +EGY+P N
Sbjct: 83 VVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSN 131
>gi|224177511 sorting nexin 18 isoform c [Homo sapiens]
Length = 591
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/92 (32%), Positives = 43/92 (46%), Gaps = 8/92 (8%)
Query: 487 YDFQARNSSELSVKQRDVLEVL--DDSRKWWKVRDPAGQEGYVPYN----ILTPYPGPRL 540
YDF++ N E+S+++ +VL + D W + + G G P + I P PGP
Sbjct: 9 YDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAG 68
Query: 541 HHSQ-SPARSLNSTPPPPPAPAPAPPPALARP 571
+PAR N PP P P PPA +P
Sbjct: 69 DGGPGAPARYAN-VPPGGFEPLPVAPPASFKP 99
>gi|157057545 sorting nexin 18 isoform a [Homo sapiens]
Length = 624
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/92 (32%), Positives = 43/92 (46%), Gaps = 8/92 (8%)
Query: 487 YDFQARNSSELSVKQRDVLEVL--DDSRKWWKVRDPAGQEGYVPYN----ILTPYPGPRL 540
YDF++ N E+S+++ +VL + D W + + G G P + I P PGP
Sbjct: 9 YDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAG 68
Query: 541 HHSQ-SPARSLNSTPPPPPAPAPAPPPALARP 571
+PAR N PP P P PPA +P
Sbjct: 69 DGGPGAPARYAN-VPPGGFEPLPVAPPASFKP 99
>gi|157057543 sorting nexin 18 isoform b [Homo sapiens]
Length = 628
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/92 (32%), Positives = 43/92 (46%), Gaps = 8/92 (8%)
Query: 487 YDFQARNSSELSVKQRDVLEVL--DDSRKWWKVRDPAGQEGYVPYN----ILTPYPGPRL 540
YDF++ N E+S+++ +VL + D W + + G G P + I P PGP
Sbjct: 9 YDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAG 68
Query: 541 HHSQ-SPARSLNSTPPPPPAPAPAPPPALARP 571
+PAR N PP P P PPA +P
Sbjct: 69 DGGPGAPARYAN-VPPGGFEPLPVAPPASFKP 99
>gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens]
Length = 1090
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/54 (40%), Positives = 32/54 (59%), Gaps = 5/54 (9%)
Query: 487 YDFQARNSSELSVKQRDVLEVL----DDSRKWWKVRDPAGQEGYVPYNILTPYP 536
+D++A+NS ELS + D L +L + +WW R +EGYVP N+L YP
Sbjct: 1028 WDYEAQNSDELSFHEGDALTILRRKDESETEWWWAR-LGDREGYVPKNLLGLYP 1080
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 42.4 bits (98), Expect = 0.002
Identities = 37/149 (24%), Positives = 59/149 (39%), Gaps = 17/149 (11%)
Query: 403 RPGLELSPEEGPPYRP--EFFSGWEPPVTDPQSRAWEDPVEKQ-LQHERRRRQQSAPQVA 459
RP + + PP P + +PP P + + P +++ LQH +++ +
Sbjct: 179 RPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLD 238
Query: 460 VN-GHRDLEPESEP-------------QLESETAGKWVLCNYDFQARNSSELSVKQRDVL 505
+N GH SE QL++ +W YDF+A EL +V+
Sbjct: 239 INDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVV 298
Query: 506 EVLDDSRKWWKVRDPAGQEGYVPYNILTP 534
EVLD S W + G P N + P
Sbjct: 299 EVLDSSNPSWWTGRLHNKLGLFPANYVAP 327
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/49 (38%), Positives = 28/49 (57%), Gaps = 1/49 (2%)
Query: 484 LCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNIL 532
+ +DF A ELS DVL++L + +W+K + QEGYVP N +
Sbjct: 4 VAKFDFTASGEDELSFHTGDVLKILSNQEEWFKA-ELGSQEGYVPKNFI 51
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 8/109 (7%)
Query: 425 EPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVL 484
E P+ + W P++ Q + P + V H P E E + +V+
Sbjct: 12 EKPIKEKDKGQWS-PLKVSAQD---KDAPPLPPLVVFNHLTPPPPDEHLDEDK---HFVV 64
Query: 485 CNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRD-PAGQEGYVPYNIL 532
YD+ A N +L + + + L+VL + WW R G+EGYVP N +
Sbjct: 65 ALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFV 113
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/47 (46%), Positives = 31/47 (65%), Gaps = 2/47 (4%)
Query: 483 VLCNYDFQARNSSELSVKQRDVLEVLDDSRK-WWKVRDPAGQEGYVP 528
V+ YDFQAR+ E+++K+ DVL +L K WWKV + A +G VP
Sbjct: 982 VMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKV-EAADHQGIVP 1027
>gi|187761324 shootin1 isoform a [Homo sapiens]
Length = 631
Score = 42.0 bits (97), Expect = 0.002
Identities = 65/289 (22%), Positives = 109/289 (37%), Gaps = 61/289 (21%)
Query: 442 KQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQ 501
+QL+ ER + QQ ++ E QLE+ET K + ++KQ
Sbjct: 274 QQLEEERIQHQQKVKEL------------EEQLENETLHKEIH-------------NLKQ 308
Query: 502 RDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPA 561
+ LE+L++ +K +++ +E R++ S+ NS PPPPP P
Sbjct: 309 Q--LELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSE------NSVPPPPPPPP 360
Query: 562 PAPPP---------ALARPRWDRPRWDSCDSLNGLDPSEKEKFSQM-LIVNEELQARLAQ 611
P PPP ++ R R P P E+ + + EE+ R+ +
Sbjct: 361 PLPPPPPNPIRSLMSMIRKR-SHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKK 419
Query: 612 GRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEE 671
G P + P+ P S +KG S VD L + G S
Sbjct: 420 G----VHLRPVNQTARPKTKPES----------SKGCES-AVDELKGILGTLNKSTSSRS 464
Query: 672 LRAVSPEEGARVYSQVTVQRSLLEDKEKVSE--LEAVMEKQKKKVEGEV 718
L+++ PE ++ +R + + + S + A E + V G V
Sbjct: 465 LKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVLGSV 513
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,963,038
Number of Sequences: 37866
Number of extensions: 1984991
Number of successful extensions: 23606
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 325
Number of HSP's successfully gapped in prelim test: 468
Number of HSP's that attempted gapping in prelim test: 16422
Number of HSP's gapped (non-prelim): 5411
length of query: 723
length of database: 18,247,518
effective HSP length: 110
effective length of query: 613
effective length of database: 14,082,258
effective search space: 8632424154
effective search space used: 8632424154
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.