Search of human proteins with 148536871

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148536871 ninein isoform 1 [Homo sapiens]
         (2046 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148536871 ninein isoform 1 [Homo sapiens]                         4002   0.0  
gi|33946321 ninein isoform 5 [Homo sapiens]                          3962   0.0  
gi|148536869 ninein isoform 2 [Homo sapiens]                         3962   0.0  
gi|33946313 ninein isoform 4 [Homo sapiens]                          3894   0.0  
gi|55749678 ninein-like [Homo sapiens]                                455   e-127
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   206   2e-52
gi|21735548 centrosomal protein 2 [Homo sapiens]                      204   9e-52
gi|148746195 trichohyalin [Homo sapiens]                              203   2e-51
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    202   3e-51
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   201   5e-51
gi|71061468 centromere protein E [Homo sapiens]                       197   7e-50
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       176   2e-43
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       176   2e-43
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        176   2e-43
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        176   2e-43
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        176   2e-43
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        176   2e-43
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        176   2e-43
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        176   2e-43
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]    170   1e-41
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            169   3e-41
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...   167   1e-40
gi|55770834 centromere protein F [Homo sapiens]                       163   2e-39
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        160   2e-38
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    157   1e-37
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   157   1e-37
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   157   1e-37
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   153   1e-36
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   153   1e-36
gi|109255234 centrosomal protein 290kDa [Homo sapiens]                153   2e-36

>gi|148536871 ninein isoform 1 [Homo sapiens]
          Length = 2046

 Score = 4002 bits (10379), Expect = 0.0
 Identities = 2046/2046 (100%), Positives = 2046/2046 (100%)

Query: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
            MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
Sbjct: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60

Query: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120
            RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
Sbjct: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120

Query: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180
            PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
Sbjct: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180

Query: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240
            DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
Sbjct: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240

Query: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300
            DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
Sbjct: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300

Query: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360
            GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
Sbjct: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360

Query: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420
            ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
Sbjct: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420

Query: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480
            KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
Sbjct: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480

Query: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540
            SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
Sbjct: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540

Query: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
            ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
Sbjct: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600

Query: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
            LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
Sbjct: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660

Query: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
            ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
Sbjct: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720

Query: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780
            LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
Sbjct: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780

Query: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840
            KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY
Sbjct: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840

Query: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900
            RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
Sbjct: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960
            YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA
Sbjct: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960

Query: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020
            SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK
Sbjct: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020

Query: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080
            EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
Sbjct: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080

Query: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140
            NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR
Sbjct: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140

Query: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200
            RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI
Sbjct: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200

Query: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260
            SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND
Sbjct: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260

Query: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
            CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE
Sbjct: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320

Query: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380
            LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV
Sbjct: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380

Query: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440
            HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF
Sbjct: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440

Query: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500
            QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI
Sbjct: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500

Query: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560
            TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET
Sbjct: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560

Query: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620
            VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ
Sbjct: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620

Query: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680
            KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK
Sbjct: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680

Query: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740
            DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI
Sbjct: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740

Query: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800
            ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
Sbjct: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800

Query: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860
            QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ
Sbjct: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860

Query: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920
            TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS
Sbjct: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920

Query: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980
            PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
Sbjct: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980

Query: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQALLPEQRAVHADSY 2040
            LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQALLPEQRAVHADSY
Sbjct: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQALLPEQRAVHADSY 2040

Query: 2041 RRIGHL 2046
            RRIGHL
Sbjct: 2041 RRIGHL 2046


>gi|33946321 ninein isoform 5 [Homo sapiens]
          Length = 2090

 Score = 3962 bits (10276), Expect = 0.0
 Identities = 2026/2026 (100%), Positives = 2026/2026 (100%)

Query: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
            MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
Sbjct: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60

Query: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120
            RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
Sbjct: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120

Query: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180
            PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
Sbjct: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180

Query: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240
            DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
Sbjct: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240

Query: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300
            DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
Sbjct: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300

Query: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360
            GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
Sbjct: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360

Query: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420
            ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
Sbjct: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420

Query: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480
            KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
Sbjct: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480

Query: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540
            SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
Sbjct: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540

Query: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
            ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
Sbjct: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600

Query: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
            LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
Sbjct: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660

Query: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
            ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
Sbjct: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720

Query: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780
            LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
Sbjct: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780

Query: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840
            KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY
Sbjct: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840

Query: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900
            RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
Sbjct: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960
            YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA
Sbjct: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960

Query: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020
            SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK
Sbjct: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020

Query: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080
            EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
Sbjct: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080

Query: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140
            NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR
Sbjct: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140

Query: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200
            RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI
Sbjct: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200

Query: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260
            SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND
Sbjct: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260

Query: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
            CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE
Sbjct: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320

Query: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380
            LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV
Sbjct: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380

Query: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440
            HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF
Sbjct: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440

Query: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500
            QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI
Sbjct: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500

Query: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560
            TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET
Sbjct: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560

Query: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620
            VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ
Sbjct: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620

Query: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680
            KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK
Sbjct: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680

Query: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740
            DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI
Sbjct: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740

Query: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800
            ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
Sbjct: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800

Query: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860
            QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ
Sbjct: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860

Query: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920
            TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS
Sbjct: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920

Query: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980
            PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
Sbjct: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980

Query: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ 2026
            LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ
Sbjct: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ 2026



 Score =  139 bits (350), Expect = 3e-32
 Identities = 341/1666 (20%), Positives = 669/1666 (40%), Gaps = 329/1666 (19%)

Query: 308  ERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLAL-ENELLVTKNSIHQAALASFK 366
            E+IL    ++ +E  QEI KA     + N     L L+L EN  L  +   +   LA ++
Sbjct: 442  EQILQQAGKQRLELEQEIEKA---KTEENYIRDRLALSLKENSRLENELLENAEKLAEYE 498

Query: 367  AEIRHLLERVDQVVREK---------------EKLRSDLDKAEKLKSLMASEVDDHHAAI 411
                 L   ++ V+ EK               E+L    ++ E+   ++  +VD+  + +
Sbjct: 499  NLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL 558

Query: 412  ERRNEYNLR------KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTE 465
            E   EY  +       L     E + A    +  E     ++     + +E E+   + +
Sbjct: 559  E---EYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMK 615

Query: 466  ENYIRDRLALSLKENSRLEN------ELLENAEKLAE-----YENLTNKLQR---NLENV 511
            E + RD   L L+   ++ +      E + + +K  E     +EN T+ L++   +L+N 
Sbjct: 616  EQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNE 675

Query: 512  LAEKFGDL----------------DPSSAEFFLQEE------------------RLTQMR 537
            +AE  G                  +    +  L+EE                  RLTQ +
Sbjct: 676  IAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQ 735

Query: 538  NEYERQCRVLQ------DQVDELQSELEEYRAQGRVLRLPLKNSPSEE------VEANSG 585
              +ER+   LQ      ++V  L  ELE++  Q ++  L  K++  +E      +E +  
Sbjct: 736  ASFEREREGLQSSAWTEEKVRGLTQELEQFH-QEQLTSLVEKHTLEKEELRKELLEKHQR 794

Query: 586  GIEPEHGLGSEECNPLNMSIEA-------------ELVIEQMKEQHHRDICCLRLELEDK 632
             ++        ECN     IEA             E  ++ ++ ++ +++  L+ +  ++
Sbjct: 795  ELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREE 854

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHE 692
               +E + DE    C +AQE +K+       TL+++    K     L  +  +L++ + E
Sbjct: 855  KSQWEFEKDELTQECAEAQELLKE-------TLKRE----KTTSLVLTQEREMLEKTYKE 903

Query: 693  ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTE 752
                   E++QL   LE+ +   + +  L  +  L+ + +  +   ERE    Q+ A +E
Sbjct: 904  HLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA-SE 962

Query: 753  EKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTS 812
            +      + LE  H ++   ++ K  L  E + K   E   RE    R +M TE +R  S
Sbjct: 963  QLASQRLERLEMEHDQERQEMMSK-LLAMENIHKATCETADRE----RAEMSTEISRLQS 1017

Query: 813  QIE---------AQFQSDCQKVTER---CESALQSLE---------GRYRQELKDLQEQQ 851
            +I+         +  QS CQ + E     + AL  L+         G     L+   EQ 
Sbjct: 1018 KIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQA 1077

Query: 852  REEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMV-- 909
             +E  +   E   L Q   + +  L  +   ++  +       E  E   +++    V  
Sbjct: 1078 VKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEG 1137

Query: 910  VERQQLLQDLED--LRNVSETQQSLLSDQILELKSSHKR-----ELREREEVLCQAGASE 962
            V R+ +L DLED  +R++  T  S +  Q ++++ S        EL   EE   ++   +
Sbjct: 1138 VTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELK 1197

Query: 963  QLASQRLERLEM------EHDQERQEMM-------SKLLAMENI------HKATCETADR 1003
               SQ  E+L M         +++Q+++        KL  +E I      +K   E   R
Sbjct: 1198 NQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSR 1257

Query: 1004 ER---------------------AEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE 1042
            E                       E++ E+ RLQ ++K+M++ T     L+     +  E
Sbjct: 1258 ENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIE 1317

Query: 1043 EVEGD-------GALSLLQQG--------------EQLLEENGDVLLSLQRAHEQAVKEN 1081
              E +       G +  LQ+               E L  E    +L L +  E+ V   
Sbjct: 1318 NEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRV 1377

Query: 1082 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE--------QTEPFLQQNRTK 1133
              +   I   +Q  Q LE    +   +      +   T +        Q +  L++N T 
Sbjct: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1437

Query: 1134 ---QVEGVTRRHVLSDLEDDEV------RDLGSTGTSSVQRQEV-----KIEESEASVEG 1179
               Q +    +  +++LE ++       R L    T  V++++V     K EE +A +  
Sbjct: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497

Query: 1180 F----SELEN--------SEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFD 1227
                 SE++         SE+ + E+  L+N+I+ L E+  +        +  ++++   
Sbjct: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1557

Query: 1228 VSVLKKK----LKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETRYDEA 1276
               +K++     KM+E + +   + K+  + +  EN  L       QE+L+ +  R  E 
Sbjct: 1558 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1617

Query: 1277 LENNK---------ELTAEVFRLQDELKKMEEVTETFLS-LEKSYDEVKIENEELNVLVL 1326
            L   +         E   E F L++EL++ +  + T +S LE    EVKI+   +     
Sbjct: 1618 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1677

Query: 1327 RLQGKIEKLQESVVQRC-DCCLWEASLENLEIEPDGNILQ----LNQTLEECVPRVRS-- 1379
             L+ ++EK+++  + RC D   ++  + ++ +  +  +L+    L++ L  CV ++    
Sbjct: 1678 LLKDELEKMKQ--LHRCPDLSDFQQKISSV-LSYNEKLLKEKEALSEELNSCVDKLAKSS 1734

Query: 1380 -VHHVIEECKQENQYLEGNTQLLEK---VKAHEIAWLHGTIQT---------HQERPRVQ 1426
             + H I   KQE +  E  +  L+        ++  L  T+Q             R   Q
Sbjct: 1735 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1794

Query: 1427 NQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK-ERVTILVKQKDVLSHG 1485
             +  L++    L  Q ++   ++   E+    + L    ++L  +++  L+ ++  L   
Sbjct: 1795 EKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ 1854

Query: 1486 EKEEELKAMMHDLQITCSEMQQKVELLRYESEKL----------------QQENSILRNE 1529
            E E  L+ M+ + +   +  ++KV  L  ES  L                +QE   L+ E
Sbjct: 1855 ENER-LQTMVQNTKAELTHSREKVRQL--ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE 1911

Query: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
                 +E S +N K+  +N  ++E+    ET+  EN  ++K    L +Q+ E++      
Sbjct: 1912 CDQFQKEQSPANRKVSQMNSLEQEL----ETIHLENEGLKKKQVKLDEQLMEMQ------ 1961

Query: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649
             L +T  +   S +   LQ L Q+   M+ +++       L + E+   +L+EELE    
Sbjct: 1962 HLRSTA-TPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTS 2020

Query: 1650 QSST-------LVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
            +++T       LV+ +E  + EV+ +  +V++   LL++++ ++K+
Sbjct: 2021 ETNTPQGNQEQLVTVMEERMIEVEQKLKLVKR---LLQEKVNQLKE 2063



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 253/1217 (20%), Positives = 489/1217 (40%), Gaps = 168/1217 (13%)

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEY-----KE 428
            E ++ +V E+++L  DL+    +     S + D    ++  ++  LR+ +E        E
Sbjct: 903  EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASE 962

Query: 429  RIAALKNE-LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENEL 487
            ++A+ + E L  E +Q  Q+   + L +E  I KA T E   R+R  +S  E SRL++++
Sbjct: 963  QLASQRLERLEMEHDQERQEMMSKLLAMEN-IHKA-TCETADRERAEMST-EISRLQSKI 1019

Query: 488  LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS-----SAEFFLQE--ERLTQMRNEY 540
             E  +  +    L +  Q     V+ E+  + D +       E  L+E  + L  ++  +
Sbjct: 1020 KEMQQATSPLSMLQSGCQ-----VIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAH 1074

Query: 541  ERQCRV---LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEE 597
            E+  +    +  ++  LQ  L++    G V+   L + P+ E   N+   + E  L    
Sbjct: 1075 EQAVKENVKMATEISRLQQRLQKLEP-GLVMSSCL-DEPATEFFGNTAE-QTEPFLQQNR 1131

Query: 598  CNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 657
               +   +    V+  +++   RD+          V+  E +++E+  S +   E ++  
Sbjct: 1132 TKQVE-GVTRRHVLSDLEDDEVRDLGSTGTS---SVQRQEVKIEESEASVEGFSE-LENS 1186

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQE 717
             E  T + E     LKN+I++LQ Q  +L      A C    EKKQ    L  + + L++
Sbjct: 1187 EETRTESWE-----LKNQISQLQEQLMMLC-----ADCDRASEKKQ---DLLFDVSVLKK 1233

Query: 718  KLRLQHEM-ELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK 776
            KL++   + E   +         RE + LQ      E++R +    ++  +       E 
Sbjct: 1234 KLKMLERIPEASPKYKLLYEDVSRENDCLQ------EELRMMETRYDEALENNKELTAEV 1287

Query: 777  HTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK----VTERC--- 829
              L+ E  + E + +    L++  ++++ E N   + +  + Q   +K    V +RC   
Sbjct: 1288 FRLQDELKKMEEVTETFLSLEKSYDEVKIE-NEELNVLVLRLQGKIEKLQESVVQRCDCC 1346

Query: 830  --ESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLK-ETLKREKTT 886
              E++L++LE      +  L  Q  EE          + +EC +  + L+  T   EK  
Sbjct: 1347 LWEASLENLEIEPDGNILQLN-QTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEK-- 1403

Query: 887  SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ---QSLLSDQILELKSS 943
              V   E   L  T + H     V+ Q +L++   L    +     Q+ +++  LE    
Sbjct: 1404 --VKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461

Query: 944  HK--RELREREEVLCQAGASEQLASQRLERLEMEHD--------QERQEMM---SKLLAM 990
             +  R+L+ER  +L +         +  E   M HD        Q++ E++   S+ L  
Sbjct: 1462 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1521

Query: 991  EN-IHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
            EN I +    T + E +  + ++  L    +EM Q T  +    +  Q + E   +    
Sbjct: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581

Query: 1050 LSLLQQ-----GEQLLEENGDVLLSLQRAHE-------QAVKENVKMATEISRLQQRL-- 1095
            L +  Q       +L ++N      LQ  ++       Q  KE    A E  R Q++   
Sbjct: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE-EREQEKFNL 1640

Query: 1096 -QKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGVTRRHVLSDLED--D 1150
             ++LE   V SS L             QT    Q+N     ++E + + H   DL D   
Sbjct: 1641 KEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQ 1700

Query: 1151 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSE---LENSEETRTE---SWELKNQISQLQ 1204
            ++  + S     ++ +E   EE  + V+  ++   LE+   T  +   SWE  +Q + L+
Sbjct: 1701 KISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWE--HQSASLK 1758

Query: 1205 EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK-----YKLLY------- 1252
             QL+          +  Q++   +S +K  L++ ++  EA  +     +K L        
Sbjct: 1759 SQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1818

Query: 1253 --EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1310
              E  +  +    ++ R+   + D  +   ++L   +++  + L+ M + T+     E +
Sbjct: 1819 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQL---LWQENERLQTMVQNTKA----ELT 1871

Query: 1311 YDEVKIENEELNVLV-----LRLQGKIEKLQE---SVVQRCDCCLWEASLENLEIEPDGN 1362
            +   K+   E N+L      L   G +   ++   S+ + CD    E S  N ++    +
Sbjct: 1872 HSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNS 1931

Query: 1363 ILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNT-----------QLLEK-----VKA 1406
            + Q  +T+      ++     ++E   E Q+L               QLL++     V  
Sbjct: 1932 LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1991

Query: 1407 HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAE---------LELE 1457
             +   L   +    ER     Q  LE  T+       + +   T+ E         L+L 
Sbjct: 1992 EQFLQLQRQL-LQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV 2050

Query: 1458 KTKLQELTRKLKERVTI 1474
            K  LQE   +LKE+V++
Sbjct: 2051 KRLLQEKVNQLKEQVSL 2067



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 46/224 (20%), Positives = 98/224 (43%), Gaps = 18/224 (8%)

Query: 347  ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 406
            E +LL  +N   Q  + + KAE+ H  E+V Q+          L K +K  +   +    
Sbjct: 1848 EQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL------LPKHQKHLNPSGTMNPT 1901

Query: 407  HHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI-LQQAG--KQRLELEQEIEKAK 463
                +  + E +  + ++    R  +  N L +E E I L+  G  K++++L++++ + +
Sbjct: 1902 EQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQ 1961

Query: 464  --------TEENYIRDRLALSLKENSRLENE-LLENAEKLAEYENLTNKLQRNLENVLAE 514
                    +   +  D   L  +    +  E  L+   +L + E +   LQ  LEN  +E
Sbjct: 1962 HLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSE 2021

Query: 515  KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL 558
                         + EER+ ++  + +   R+LQ++V++L+ ++
Sbjct: 2022 TNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2065


>gi|148536869 ninein isoform 2 [Homo sapiens]
          Length = 2133

 Score = 3962 bits (10276), Expect = 0.0
 Identities = 2026/2026 (100%), Positives = 2026/2026 (100%)

Query: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
            MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
Sbjct: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60

Query: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120
            RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
Sbjct: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120

Query: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180
            PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
Sbjct: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180

Query: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240
            DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
Sbjct: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240

Query: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300
            DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
Sbjct: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300

Query: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360
            GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
Sbjct: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360

Query: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420
            ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
Sbjct: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420

Query: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480
            KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
Sbjct: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480

Query: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540
            SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
Sbjct: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540

Query: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
            ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
Sbjct: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600

Query: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
            LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
Sbjct: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660

Query: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
            ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
Sbjct: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720

Query: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780
            LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
Sbjct: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780

Query: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840
            KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY
Sbjct: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840

Query: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900
            RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
Sbjct: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960
            YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA
Sbjct: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960

Query: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020
            SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK
Sbjct: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020

Query: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080
            EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
Sbjct: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080

Query: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140
            NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR
Sbjct: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140

Query: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200
            RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI
Sbjct: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200

Query: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260
            SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND
Sbjct: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260

Query: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
            CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE
Sbjct: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320

Query: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380
            LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV
Sbjct: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380

Query: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440
            HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF
Sbjct: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440

Query: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500
            QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI
Sbjct: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500

Query: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560
            TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET
Sbjct: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560

Query: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620
            VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ
Sbjct: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620

Query: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680
            KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK
Sbjct: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680

Query: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740
            DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI
Sbjct: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740

Query: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800
            ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
Sbjct: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800

Query: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860
            QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ
Sbjct: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860

Query: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920
            TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS
Sbjct: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920

Query: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980
            PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
Sbjct: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980

Query: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ 2026
            LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ
Sbjct: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ 2026



 Score =  145 bits (367), Expect = 3e-34
 Identities = 355/1721 (20%), Positives = 696/1721 (40%), Gaps = 334/1721 (19%)

Query: 308  ERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLAL-ENELLVTKNSIHQAALASFK 366
            E+IL    ++ +E  QEI KA     + N     L L+L EN  L  +   +   LA ++
Sbjct: 442  EQILQQAGKQRLELEQEIEKA---KTEENYIRDRLALSLKENSRLENELLENAEKLAEYE 498

Query: 367  AEIRHLLERVDQVVREK---------------EKLRSDLDKAEKLKSLMASEVDDHHAAI 411
                 L   ++ V+ EK               E+L    ++ E+   ++  +VD+  + +
Sbjct: 499  NLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL 558

Query: 412  ERRNEYNLR------KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTE 465
            E   EY  +       L     E + A    +  E     ++     + +E E+   + +
Sbjct: 559  E---EYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMK 615

Query: 466  ENYIRDRLALSLKENSRLEN------ELLENAEKLAE-----YENLTNKLQR---NLENV 511
            E + RD   L L+   ++ +      E + + +K  E     +EN T+ L++   +L+N 
Sbjct: 616  EQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNE 675

Query: 512  LAEKFGDL----------------DPSSAEFFLQEE------------------RLTQMR 537
            +AE  G                  +    +  L+EE                  RLTQ +
Sbjct: 676  IAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQ 735

Query: 538  NEYERQCRVLQ------DQVDELQSELEEYRAQGRVLRLPLKNSPSEE------VEANSG 585
              +ER+   LQ      ++V  L  ELE++  Q ++  L  K++  +E      +E +  
Sbjct: 736  ASFEREREGLQSSAWTEEKVRGLTQELEQFH-QEQLTSLVEKHTLEKEELRKELLEKHQR 794

Query: 586  GIEPEHGLGSEECNPLNMSIEA-------------ELVIEQMKEQHHRDICCLRLELEDK 632
             ++        ECN     IEA             E  ++ ++ ++ +++  L+ +  ++
Sbjct: 795  ELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREE 854

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHE 692
               +E + DE    C +AQE +K+       TL+++    K     L  +  +L++ + E
Sbjct: 855  KSQWEFEKDELTQECAEAQELLKE-------TLKRE----KTTSLVLTQEREMLEKTYKE 903

Query: 693  ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTE 752
                   E++QL   LE+ +   + +  L  +  L+ + +  +   ERE    Q+ A +E
Sbjct: 904  HLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA-SE 962

Query: 753  EKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTS 812
            +      + LE  H ++   ++ K  L  E + K   E   RE    R +M TE +R  S
Sbjct: 963  QLASQRLERLEMEHDQERQEMMSK-LLAMENIHKATCETADRE----RAEMSTEISRLQS 1017

Query: 813  QIE---------AQFQSDCQKVTER---CESALQSLE---------GRYRQELKDLQEQQ 851
            +I+         +  QS CQ + E     + AL  L+         G     L+   EQ 
Sbjct: 1018 KIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQA 1077

Query: 852  REEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMV-- 909
             +E  +   E   L Q   + +  L  +   ++  +       E  E   +++    V  
Sbjct: 1078 VKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEG 1137

Query: 910  VERQQLLQDLED--LRNVSETQQSLLSDQILELKSSHKR-----ELREREEVLCQAGASE 962
            V R+ +L DLED  +R++  T  S +  Q ++++ S        EL   EE   ++   +
Sbjct: 1138 VTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELK 1197

Query: 963  QLASQRLERLEM------EHDQERQEMM-------SKLLAMENI------HKATCETADR 1003
               SQ  E+L M         +++Q+++        KL  +E I      +K   E   R
Sbjct: 1198 NQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSR 1257

Query: 1004 ER---------------------AEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE 1042
            E                       E++ E+ RLQ ++K+M++ T     L+     +  E
Sbjct: 1258 ENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIE 1317

Query: 1043 EVEGD-------GALSLLQQG--------------EQLLEENGDVLLSLQRAHEQAVKEN 1081
              E +       G +  LQ+               E L  E    +L L +  E+ V   
Sbjct: 1318 NEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRV 1377

Query: 1082 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE--------QTEPFLQQNRTK 1133
              +   I   +Q  Q LE    +   +      +   T +        Q +  L++N T 
Sbjct: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1437

Query: 1134 ---QVEGVTRRHVLSDLEDDEV------RDLGSTGTSSVQRQEV-----KIEESEASVEG 1179
               Q +    +  +++LE ++       R L    T  V++++V     K EE +A +  
Sbjct: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497

Query: 1180 F----SELEN--------SEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFD 1227
                 SE++         SE+ + E+  L+N+I+ L E+  +        +  ++++   
Sbjct: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1557

Query: 1228 VSVLKKK----LKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETRYDEA 1276
               +K++     KM+E + +   + K+  + +  EN  L       QE+L+ +  R  E 
Sbjct: 1558 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1617

Query: 1277 LENNK---------ELTAEVFRLQDELKKMEEVTETFLS-LEKSYDEVKIENEELNVLVL 1326
            L   +         E   E F L++EL++ +  + T +S LE    EVKI+   +     
Sbjct: 1618 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1677

Query: 1327 RLQGKIEKLQESVVQRC-DCCLWEASLENLEIEPDGNILQ----LNQTLEECVPRVRS-- 1379
             L+ ++EK+++  + RC D   ++  + ++ +  +  +L+    L++ L  CV ++    
Sbjct: 1678 LLKDELEKMKQ--LHRCPDLSDFQQKISSV-LSYNEKLLKEKEALSEELNSCVDKLAKSS 1734

Query: 1380 -VHHVIEECKQENQYLEGNTQLLEK---VKAHEIAWLHGTIQT---------HQERPRVQ 1426
             + H I   KQE +  E  +  L+        ++  L  T+Q             R   Q
Sbjct: 1735 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1794

Query: 1427 NQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK-ERVTILVKQKDVLSHG 1485
             +  L++    L  Q ++   ++   E+    + L    ++L  +++  L+ ++  L   
Sbjct: 1795 EKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ 1854

Query: 1486 EKEEELKAMMHDLQITCSEMQQKVELLRYESEKL----------------QQENSILRNE 1529
            E E  L+ M+ + +   +  ++KV  L  ES  L                +QE   L+ E
Sbjct: 1855 ENER-LQTMVQNTKAELTHSREKVRQL--ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE 1911

Query: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
                 +E S +N K+  +N  ++E+    ET+  EN  ++K    L +Q+ E++      
Sbjct: 1912 CDQFQKEQSPANRKVSQMNSLEQEL----ETIHLENEGLKKKQVKLDEQLMEMQ------ 1961

Query: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649
             L +T  +   S +   LQ L Q+   M+ +++       L + E+   +L+EELE    
Sbjct: 1962 HLRSTA-TPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTS 2020

Query: 1650 QSST-------LVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKI 1702
            +++T       LV+ +E  + EV+ +  +V++   LL++++ ++K+   C + +     +
Sbjct: 2021 ETNTPQGNQEQLVTVMEERMIEVEQKLKLVKR---LLQEKVNQLKE-QLCKN-TKADAMV 2075

Query: 1703 SSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATM 1743
              +   N +LLK  E ++E+     +K  K+ LLE +IA++
Sbjct: 2076 KDLYVENAQLLKALE-VTEQRQKTAEK--KNYLLEEKIASL 2113


>gi|33946313 ninein isoform 4 [Homo sapiens]
          Length = 2096

 Score = 3894 bits (10099), Expect = 0.0
 Identities = 1992/1997 (99%), Positives = 1993/1997 (99%)

Query: 30   QEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 89
            Q    +LCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD
Sbjct: 36   QHVKNELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 95

Query: 90   CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 149
            CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT
Sbjct: 96   CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 155

Query: 150  QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 209
            QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS
Sbjct: 156  QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 215

Query: 210  ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 269
            ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS
Sbjct: 216  ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 275

Query: 270  MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 329
            MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL
Sbjct: 276  MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 335

Query: 330  DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 389
            DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD
Sbjct: 336  DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 395

Query: 390  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 449
            LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG
Sbjct: 396  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 455

Query: 450  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509
            KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE
Sbjct: 456  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 515

Query: 510  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 569
            NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR
Sbjct: 516  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 575

Query: 570  LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 629
            LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL
Sbjct: 576  LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 635

Query: 630  EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689
            EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA
Sbjct: 636  EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 695

Query: 690  HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749
            HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA
Sbjct: 696  HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 755

Query: 750  WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 809
            WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR
Sbjct: 756  WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 815

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869
            RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC
Sbjct: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875

Query: 870  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929
            AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ
Sbjct: 876  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 935

Query: 930  QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
            QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA
Sbjct: 936  QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995

Query: 990  MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
            MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA
Sbjct: 996  MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055

Query: 1050 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1109
            LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD
Sbjct: 1056 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1115

Query: 1110 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1169
            EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK
Sbjct: 1116 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1175

Query: 1170 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1229
            IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS
Sbjct: 1176 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1235

Query: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289
            VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR
Sbjct: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1295

Query: 1290 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1349
            LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE
Sbjct: 1296 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1355

Query: 1350 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1409
            ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI
Sbjct: 1356 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1415

Query: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1469
            AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK
Sbjct: 1416 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1475

Query: 1470 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1529
            ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE
Sbjct: 1476 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1535

Query: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
            ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL
Sbjct: 1536 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1595

Query: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649
            DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV
Sbjct: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1655

Query: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1709
            QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN
Sbjct: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1715

Query: 1710 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769
            EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ
Sbjct: 1716 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1775

Query: 1770 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1829
            NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL
Sbjct: 1776 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1835

Query: 1830 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1889
            HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ
Sbjct: 1836 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1895

Query: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949
            KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK
Sbjct: 1896 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1955

Query: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2009
            QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ
Sbjct: 1956 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2015

Query: 2010 HLQEELENRTSETNTPQ 2026
            HLQEELENRTSETNTPQ
Sbjct: 2016 HLQEELENRTSETNTPQ 2032



 Score =  139 bits (350), Expect = 3e-32
 Identities = 341/1666 (20%), Positives = 669/1666 (40%), Gaps = 329/1666 (19%)

Query: 308  ERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLAL-ENELLVTKNSIHQAALASFK 366
            E+IL    ++ +E  QEI KA     + N     L L+L EN  L  +   +   LA ++
Sbjct: 448  EQILQQAGKQRLELEQEIEKA---KTEENYIRDRLALSLKENSRLENELLENAEKLAEYE 504

Query: 367  AEIRHLLERVDQVVREK---------------EKLRSDLDKAEKLKSLMASEVDDHHAAI 411
                 L   ++ V+ EK               E+L    ++ E+   ++  +VD+  + +
Sbjct: 505  NLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL 564

Query: 412  ERRNEYNLR------KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTE 465
            E   EY  +       L     E + A    +  E     ++     + +E E+   + +
Sbjct: 565  E---EYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMK 621

Query: 466  ENYIRDRLALSLKENSRLEN------ELLENAEKLAE-----YENLTNKLQR---NLENV 511
            E + RD   L L+   ++ +      E + + +K  E     +EN T+ L++   +L+N 
Sbjct: 622  EQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNE 681

Query: 512  LAEKFGDL----------------DPSSAEFFLQEE------------------RLTQMR 537
            +AE  G                  +    +  L+EE                  RLTQ +
Sbjct: 682  IAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQ 741

Query: 538  NEYERQCRVLQ------DQVDELQSELEEYRAQGRVLRLPLKNSPSEE------VEANSG 585
              +ER+   LQ      ++V  L  ELE++  Q ++  L  K++  +E      +E +  
Sbjct: 742  ASFEREREGLQSSAWTEEKVRGLTQELEQFH-QEQLTSLVEKHTLEKEELRKELLEKHQR 800

Query: 586  GIEPEHGLGSEECNPLNMSIEA-------------ELVIEQMKEQHHRDICCLRLELEDK 632
             ++        ECN     IEA             E  ++ ++ ++ +++  L+ +  ++
Sbjct: 801  ELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREE 860

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHE 692
               +E + DE    C +AQE +K+       TL+++    K     L  +  +L++ + E
Sbjct: 861  KSQWEFEKDELTQECAEAQELLKE-------TLKRE----KTTSLVLTQEREMLEKTYKE 909

Query: 693  ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTE 752
                   E++QL   LE+ +   + +  L  +  L+ + +  +   ERE    Q+ A +E
Sbjct: 910  HLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA-SE 968

Query: 753  EKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTS 812
            +      + LE  H ++   ++ K  L  E + K   E   RE    R +M TE +R  S
Sbjct: 969  QLASQRLERLEMEHDQERQEMMSK-LLAMENIHKATCETADRE----RAEMSTEISRLQS 1023

Query: 813  QIE---------AQFQSDCQKVTER---CESALQSLE---------GRYRQELKDLQEQQ 851
            +I+         +  QS CQ + E     + AL  L+         G     L+   EQ 
Sbjct: 1024 KIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQA 1083

Query: 852  REEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMV-- 909
             +E  +   E   L Q   + +  L  +   ++  +       E  E   +++    V  
Sbjct: 1084 VKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEG 1143

Query: 910  VERQQLLQDLED--LRNVSETQQSLLSDQILELKSSHKR-----ELREREEVLCQAGASE 962
            V R+ +L DLED  +R++  T  S +  Q ++++ S        EL   EE   ++   +
Sbjct: 1144 VTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELK 1203

Query: 963  QLASQRLERLEM------EHDQERQEMM-------SKLLAMENI------HKATCETADR 1003
               SQ  E+L M         +++Q+++        KL  +E I      +K   E   R
Sbjct: 1204 NQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSR 1263

Query: 1004 ER---------------------AEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE 1042
            E                       E++ E+ RLQ ++K+M++ T     L+     +  E
Sbjct: 1264 ENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIE 1323

Query: 1043 EVEGD-------GALSLLQQG--------------EQLLEENGDVLLSLQRAHEQAVKEN 1081
              E +       G +  LQ+               E L  E    +L L +  E+ V   
Sbjct: 1324 NEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRV 1383

Query: 1082 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE--------QTEPFLQQNRTK 1133
              +   I   +Q  Q LE    +   +      +   T +        Q +  L++N T 
Sbjct: 1384 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1443

Query: 1134 ---QVEGVTRRHVLSDLEDDEV------RDLGSTGTSSVQRQEV-----KIEESEASVEG 1179
               Q +    +  +++LE ++       R L    T  V++++V     K EE +A +  
Sbjct: 1444 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1503

Query: 1180 F----SELEN--------SEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFD 1227
                 SE++         SE+ + E+  L+N+I+ L E+  +        +  ++++   
Sbjct: 1504 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1563

Query: 1228 VSVLKKK----LKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETRYDEA 1276
               +K++     KM+E + +   + K+  + +  EN  L       QE+L+ +  R  E 
Sbjct: 1564 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1623

Query: 1277 LENNK---------ELTAEVFRLQDELKKMEEVTETFLS-LEKSYDEVKIENEELNVLVL 1326
            L   +         E   E F L++EL++ +  + T +S LE    EVKI+   +     
Sbjct: 1624 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1683

Query: 1327 RLQGKIEKLQESVVQRC-DCCLWEASLENLEIEPDGNILQ----LNQTLEECVPRVRS-- 1379
             L+ ++EK+++  + RC D   ++  + ++ +  +  +L+    L++ L  CV ++    
Sbjct: 1684 LLKDELEKMKQ--LHRCPDLSDFQQKISSV-LSYNEKLLKEKEALSEELNSCVDKLAKSS 1740

Query: 1380 -VHHVIEECKQENQYLEGNTQLLEK---VKAHEIAWLHGTIQT---------HQERPRVQ 1426
             + H I   KQE +  E  +  L+        ++  L  T+Q             R   Q
Sbjct: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1800

Query: 1427 NQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK-ERVTILVKQKDVLSHG 1485
             +  L++    L  Q ++   ++   E+    + L    ++L  +++  L+ ++  L   
Sbjct: 1801 EKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ 1860

Query: 1486 EKEEELKAMMHDLQITCSEMQQKVELLRYESEKL----------------QQENSILRNE 1529
            E E  L+ M+ + +   +  ++KV  L  ES  L                +QE   L+ E
Sbjct: 1861 ENER-LQTMVQNTKAELTHSREKVRQL--ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE 1917

Query: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
                 +E S +N K+  +N  ++E+    ET+  EN  ++K    L +Q+ E++      
Sbjct: 1918 CDQFQKEQSPANRKVSQMNSLEQEL----ETIHLENEGLKKKQVKLDEQLMEMQ------ 1967

Query: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649
             L +T  +   S +   LQ L Q+   M+ +++       L + E+   +L+EELE    
Sbjct: 1968 HLRSTA-TPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTS 2026

Query: 1650 QSST-------LVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
            +++T       LV+ +E  + EV+ +  +V++   LL++++ ++K+
Sbjct: 2027 ETNTPQGNQEQLVTVMEERMIEVEQKLKLVKR---LLQEKVNQLKE 2069



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 253/1217 (20%), Positives = 489/1217 (40%), Gaps = 168/1217 (13%)

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEY-----KE 428
            E ++ +V E+++L  DL+    +     S + D    ++  ++  LR+ +E        E
Sbjct: 909  EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASE 968

Query: 429  RIAALKNE-LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENEL 487
            ++A+ + E L  E +Q  Q+   + L +E  I KA T E   R+R  +S  E SRL++++
Sbjct: 969  QLASQRLERLEMEHDQERQEMMSKLLAMEN-IHKA-TCETADRERAEMST-EISRLQSKI 1025

Query: 488  LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS-----SAEFFLQE--ERLTQMRNEY 540
             E  +  +    L +  Q     V+ E+  + D +       E  L+E  + L  ++  +
Sbjct: 1026 KEMQQATSPLSMLQSGCQ-----VIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAH 1080

Query: 541  ERQCRV---LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEE 597
            E+  +    +  ++  LQ  L++    G V+   L + P+ E   N+   + E  L    
Sbjct: 1081 EQAVKENVKMATEISRLQQRLQKLEP-GLVMSSCL-DEPATEFFGNTAE-QTEPFLQQNR 1137

Query: 598  CNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 657
               +   +    V+  +++   RD+          V+  E +++E+  S +   E ++  
Sbjct: 1138 TKQVE-GVTRRHVLSDLEDDEVRDLGSTGTS---SVQRQEVKIEESEASVEGFSE-LENS 1192

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQE 717
             E  T + E     LKN+I++LQ Q  +L      A C    EKKQ    L  + + L++
Sbjct: 1193 EETRTESWE-----LKNQISQLQEQLMMLC-----ADCDRASEKKQ---DLLFDVSVLKK 1239

Query: 718  KLRLQHEM-ELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK 776
            KL++   + E   +         RE + LQ      E++R +    ++  +       E 
Sbjct: 1240 KLKMLERIPEASPKYKLLYEDVSRENDCLQ------EELRMMETRYDEALENNKELTAEV 1293

Query: 777  HTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK----VTERC--- 829
              L+ E  + E + +    L++  ++++ E N   + +  + Q   +K    V +RC   
Sbjct: 1294 FRLQDELKKMEEVTETFLSLEKSYDEVKIE-NEELNVLVLRLQGKIEKLQESVVQRCDCC 1352

Query: 830  --ESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLK-ETLKREKTT 886
              E++L++LE      +  L  Q  EE          + +EC +  + L+  T   EK  
Sbjct: 1353 LWEASLENLEIEPDGNILQLN-QTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEK-- 1409

Query: 887  SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ---QSLLSDQILELKSS 943
              V   E   L  T + H     V+ Q +L++   L    +     Q+ +++  LE    
Sbjct: 1410 --VKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467

Query: 944  HK--RELREREEVLCQAGASEQLASQRLERLEMEHD--------QERQEMM---SKLLAM 990
             +  R+L+ER  +L +         +  E   M HD        Q++ E++   S+ L  
Sbjct: 1468 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1527

Query: 991  EN-IHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
            EN I +    T + E +  + ++  L    +EM Q T  +    +  Q + E   +    
Sbjct: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587

Query: 1050 LSLLQQ-----GEQLLEENGDVLLSLQRAHE-------QAVKENVKMATEISRLQQRL-- 1095
            L +  Q       +L ++N      LQ  ++       Q  KE    A E  R Q++   
Sbjct: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE-EREQEKFNL 1646

Query: 1096 -QKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGVTRRHVLSDLED--D 1150
             ++LE   V SS L             QT    Q+N     ++E + + H   DL D   
Sbjct: 1647 KEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQ 1706

Query: 1151 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSE---LENSEETRTE---SWELKNQISQLQ 1204
            ++  + S     ++ +E   EE  + V+  ++   LE+   T  +   SWE  +Q + L+
Sbjct: 1707 KISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWE--HQSASLK 1764

Query: 1205 EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK-----YKLLY------- 1252
             QL+          +  Q++   +S +K  L++ ++  EA  +     +K L        
Sbjct: 1765 SQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1824

Query: 1253 --EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1310
              E  +  +    ++ R+   + D  +   ++L   +++  + L+ M + T+     E +
Sbjct: 1825 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQL---LWQENERLQTMVQNTKA----ELT 1877

Query: 1311 YDEVKIENEELNVLV-----LRLQGKIEKLQE---SVVQRCDCCLWEASLENLEIEPDGN 1362
            +   K+   E N+L      L   G +   ++   S+ + CD    E S  N ++    +
Sbjct: 1878 HSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNS 1937

Query: 1363 ILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNT-----------QLLEK-----VKA 1406
            + Q  +T+      ++     ++E   E Q+L               QLL++     V  
Sbjct: 1938 LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1997

Query: 1407 HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAE---------LELE 1457
             +   L   +    ER     Q  LE  T+       + +   T+ E         L+L 
Sbjct: 1998 EQFLQLQRQL-LQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV 2056

Query: 1458 KTKLQELTRKLKERVTI 1474
            K  LQE   +LKE+V++
Sbjct: 2057 KRLLQEKVNQLKEQVSL 2073



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 46/224 (20%), Positives = 98/224 (43%), Gaps = 18/224 (8%)

Query: 347  ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 406
            E +LL  +N   Q  + + KAE+ H  E+V Q+          L K +K  +   +    
Sbjct: 1854 EQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL------LPKHQKHLNPSGTMNPT 1907

Query: 407  HHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI-LQQAG--KQRLELEQEIEKAK 463
                +  + E +  + ++    R  +  N L +E E I L+  G  K++++L++++ + +
Sbjct: 1908 EQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQ 1967

Query: 464  --------TEENYIRDRLALSLKENSRLENE-LLENAEKLAEYENLTNKLQRNLENVLAE 514
                    +   +  D   L  +    +  E  L+   +L + E +   LQ  LEN  +E
Sbjct: 1968 HLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSE 2027

Query: 515  KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL 558
                         + EER+ ++  + +   R+LQ++V++L+ ++
Sbjct: 2028 TNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071


>gi|55749678 ninein-like [Homo sapiens]
          Length = 1382

 Score =  455 bits (1170), Expect = e-127
 Identities = 306/828 (36%), Positives = 470/828 (56%), Gaps = 55/828 (6%)

Query: 1   MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
           MDE E++ + ++L+E++ S DTTGTG L ++ELT LC  L LE+  PVL QTLL ++   
Sbjct: 1   MDE-EENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFA 59

Query: 61  RVHFDQFKEALILILS-----RTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQE 115
           RV+F++FKE  + +LS     R    +    E   S    PKYV G K YGRRS PE  +
Sbjct: 60  RVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCD 119

Query: 116 SVEEFPEVTVIEPLDEEARPSHI------------PAGDCSEHWKTQRSEEYEAEGQLRF 163
           +  E   V   E   + +  SH+             + + +E  K  ++E +EA+GQL+ 
Sbjct: 120 AATEARRVP--EQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQT 177

Query: 164 WNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEM 223
           W+ +D  + Q   SP  D  E +++ V E+LG+   GHL+ ++L  +C+  GLQ ++ E 
Sbjct: 178 WDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEE 237

Query: 224 LEEVFHNLDPDGT--MSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTT 281
           LE++F+ LD DG   +S+E+F  GLF +  +L   +ST  +  K     Q  +ESG  TT
Sbjct: 238 LEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTT 297

Query: 282 TSSAMTSTIG-FRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLT 340
           T+S++ S     R+FS +DDG G A  +++L  W +EGI+N +EIL++LDFS+D  +NL 
Sbjct: 298 TTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLL 357

Query: 341 ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM 400
           ELT AL+NEL+   +++ QAALA +  E+ +   +V+Q+ RE++K R DL++AEK     
Sbjct: 358 ELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEF 417

Query: 401 ASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIE 460
             E+DD H+ +E+  E  ++ L++ Y+ER++ L++E+  ERE   +QA +QR  LE ++ 
Sbjct: 418 VKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477

Query: 461 KAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 520
           + + EE  +R++L L+LKENSRL+ E++E  EKL++ E L  KLQ++LE VL +K   L+
Sbjct: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDK---LE 534

Query: 521 PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL-KNSPSEE 579
           P SAE   QEER   +  EYE +CR LQD+ DELQ+ELE     G   RLP  ++SPS  
Sbjct: 535 PQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELE-----GLWARLPKNRHSPSWS 589

Query: 580 VEANSGGIEPEHGLG----SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRH 635
            +     +    GLG    S   N   +SIE EL++EQ+KE H++D   LR +LE KV +
Sbjct: 590 PDGRRRQLP---GLGPAGISFLGNSAPVSIETELMMEQVKE-HYQD---LRTQLETKVNY 642

Query: 636 YEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATC 695
           YE+++     + +K +++M+Q    E   LE Q +DL+ E+ E   +     +   + T 
Sbjct: 643 YEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLE-ELHEKSQEVIWGLQEQLQDTA 701

Query: 696 RHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKV 755
           R  E +   Q+ L    T     L L+H   L+    +A+A    E  GL +        
Sbjct: 702 RGPEPE---QMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGAL----PAR 754

Query: 756 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKM 803
           R LT ELE+  Q  L     + +   E+L  E   K Q    E R +M
Sbjct: 755 RDLTLELEEPPQGPL----PRGSQRSEQLELERALKLQPCASEKRAQM 798



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 210/1058 (19%), Positives = 406/1058 (38%), Gaps = 148/1058 (13%)

Query: 531  ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
            ER  +   E+ ++       +++L  +  ++  QG   RL L  S   EVEA       E
Sbjct: 408  ERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRS---EVEA-------E 457

Query: 591  HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
              L  E+ +    ++E ++   Q +E   R+   L L+   ++   +K++ E V     +
Sbjct: 458  RELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRL---QKEIVEVVEKLSDS 514

Query: 651  QENMKQRHENETHTLEKQISDLKNEI-AELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
            +    +  ++    L+ ++     E+ A+ +  AAVLKE  +E  CR  +++        
Sbjct: 515  ERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKE--YELKCRDLQDRND------ 566

Query: 710  EEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ 769
                            EL+A L    A   + R    S +W+ +   G  ++L       
Sbjct: 567  ----------------ELQAELEGLWARLPKNRH---SPSWSPD---GRRRQLPGLGPAG 604

Query: 770  LTSLVEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 828
            ++ L     +  E EL  E +++H ++L   R ++ET+ N    +I A            
Sbjct: 605  ISFLGNSAPVSIETELMMEQVKEHYQDL---RTQLETKVNYYEREIAA------------ 649

Query: 829  CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 888
                   L+  + +E KD+++ +R E S  E +K +L +   ++QE++    ++ + T+ 
Sbjct: 650  -------LKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTAR 702

Query: 889  VLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS--LLSDQILELKSSHKR 946
                E+  L     + L  + +     LQ +   R  +E + S  L     L  +     
Sbjct: 703  GPEPEQMGLAPCCTQALCGLALRHHSHLQQI---RREAEAELSGELSGLGALPARRDLTL 759

Query: 947  ELREREEVLCQAGA--SEQLASQRLERLEMEHDQERQEM-MSKLLAMENIHKATCETADR 1003
            EL E  +     G+  SEQL  +R  +L+    ++R +M +S  L  E +  A  +  D 
Sbjct: 760  ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDG 819

Query: 1004 ERAEMSTEISRLQSKIKEM-QQATSPLSMLQSGCQVIGEEEVE----GDGALSLLQQGEQ 1058
               E   +       +    Q+ T  L  L+ GC   GE  +     GDG  S    G  
Sbjct: 820  PSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGC---GERPLAWLAPGDGRESEEAAGAG 876

Query: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR-------LQKLEPGLVMSSCLDEP 1111
                      + Q         +   +   SR+Q          ++ EP    ++ L++P
Sbjct: 877  PRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQP 936

Query: 1112 ATEFFG-----NTAEQTEPFLQQNRTKQVEGVT-RRHVLSDLEDDEVRDLGSTGTSSVQR 1165
                         A QT+P + +   +       +   L  ++++  R            
Sbjct: 937  GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASE 996

Query: 1166 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK----- 1220
            Q+ +   +E ++E      + E  R  S     Q++  Q       A  +    K     
Sbjct: 997  QQAR---AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053

Query: 1221 -KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETR 1272
             K D+   +  L+  ++ LE+  +     +L +  +S EN  L       ++EL   E+ 
Sbjct: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113

Query: 1273 YD------EALENNKELTA---EVFRLQDELKK--MEEVTETFLSLEKSYDEVKIENEEL 1321
            +D      E L+ +KE      EV   Q++  K  + ++    L L +     + +NEE 
Sbjct: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173

Query: 1322 NVLVLRLQGKIEKLQESVVQRCD-CCLWEASLENLEIEPDGNIL---QLNQTLEECVPRV 1377
             V +  L   +E++  S  Q+ D        LE L  E     L   +L QTLEE   +V
Sbjct: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQV 1233

Query: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1437
            +  H  + + + +      + Q +  V    +A LH  +    E+ R +     EE+   
Sbjct: 1234 QGAHLRLRQAQAQ------HLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQ 1287

Query: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
            L   ++  +    I  L+  +  LQE   KLKE+              EK  +   ++ +
Sbjct: 1288 LKATEERVEEAEMI--LKNMEMLLQEKVDKLKEQF-------------EKNTKSDLLLKE 1332

Query: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
            L +  + + + ++    +    ++++ +L  ++  LN+
Sbjct: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 81/385 (21%), Positives = 153/385 (39%), Gaps = 72/385 (18%)

Query: 381  REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKE 440
            REK+ + + L   E +   +   VD     +   +     +L EE       LKN+L + 
Sbjct: 1053 REKDDMETKLLHLEDVVRALEKHVD-----LRENDRLEFHRLSEEN----TLLKNDLGRV 1103

Query: 441  REQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENL 500
            R++ L+ A        +EIE  K ++      + +  ++N   +++L +   ++ +    
Sbjct: 1104 RQE-LEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQ---- 1158

Query: 501  TNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 560
                       L ++       + E  +  + LTQ   E  R  +   DQ+ +L+ ELE 
Sbjct: 1159 -----------LGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207

Query: 561  YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 620
               + + L+LP  +  ++ +E +   ++  H                 L + Q + QH +
Sbjct: 1208 LNQEHQSLQLPW-SELTQTLEESQDQVQGAH-----------------LRLRQAQAQHLQ 1249

Query: 621  DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD----LKNEI 676
            ++   RL  +D+V    + L       ++  +  ++ HE +    E+++ +    LKN  
Sbjct: 1250 EV---RLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNME 1306

Query: 677  AELQGQAAVLKEAHHEATCRHEEEKKQLQVK-LEEEKTHLQEKLRLQHEMELKARLTQAQ 735
              LQ +   LKE   + T      K  L +K L  E  HL   L               Q
Sbjct: 1307 MLLQEKVDKLKEQFEKNT------KSDLLLKELYVENAHLVRAL---------------Q 1345

Query: 736  ASFEREREGLQSSAWTEEKVRGLTQ 760
            A+ E++R   + S   EEKVR L +
Sbjct: 1346 ATEEKQRGAEKQSRLLEEKVRALNK 1370



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 94/440 (21%), Positives = 180/440 (40%), Gaps = 60/440 (13%)

Query: 693  ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA------QASFEREREGLQ 746
            A+CR + E+ Q    ++EE+     +   +   E +AR   A      + S E  R G  
Sbjct: 966  ASCRGQAERLQA---IQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSL 1022

Query: 747  SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
             S       +G  QE       QL +  E  T    E  K+ +E     L++    +E  
Sbjct: 1023 PSHLQLADPQGSWQE-------QLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKH 1075

Query: 807  CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 866
             + R +      + +  +++E   + L++  GR RQEL+  +     ++ + E  K +  
Sbjct: 1076 VDLREND-----RLEFHRLSEE-NTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKE 1129

Query: 867  QECAEAQEL------LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE 920
            + C+E + L       K+ L +     L L QE    +   +EH     V  Q L Q LE
Sbjct: 1130 KACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHR----VTIQMLTQSLE 1185

Query: 921  DLRNVSETQQSLLSDQILELK----------SSHKRELREREEVLCQAGASEQLASQRLE 970
            ++    + Q    SDQI +L+           S +    E  + L ++    Q A  RL 
Sbjct: 1186 EVVRSGQQQ----SDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLR 1241

Query: 971  RLEMEH-------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1023
            + + +H        Q+R   + +LL+++   +      D +R E   ++   + +++E +
Sbjct: 1242 QAQAQHLQEVRLVPQDRVAELHRLLSLQG--EQARRRLDAQREEHEKQLKATEERVEEAE 1299

Query: 1024 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ---AVKE 1080
                 + ML        +E+ E +    LL   ++L  EN  ++ +LQ   E+   A K+
Sbjct: 1300 MILKNMEMLLQEKVDKLKEQFEKNTKSDLLL--KELYVENAHLVRALQATEEKQRGAEKQ 1357

Query: 1081 NVKMATEISRLQQRLQKLEP 1100
            +  +  ++  L + + ++ P
Sbjct: 1358 SRLLEEKVRALNKLVSRIAP 1377



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 81/382 (21%), Positives = 161/382 (42%), Gaps = 75/382 (19%)

Query: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
            L   D     Q  +A  E  +TK+  L R+  +  T L+  +DV+   EK  +L+     
Sbjct: 1026 LQLADPQGSWQEQLAAPEEGETKIA-LEREKDDMETKLLHLEDVVRALEKHVDLR----- 1079

Query: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1557
                        E  R E  +L +EN++L+N++                           
Sbjct: 1080 ------------ENDRLEFHRLSEENTLLKNDLGR------------------------- 1102

Query: 1558 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1617
               V+QE  A +   +  +K+I  LK   ++   E   L+++N   +++L +LN R+ ++
Sbjct: 1103 ---VRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQL 1159

Query: 1618 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1677
                             QE    + + E  +V    L  SLE  +   + Q+  +Q+   
Sbjct: 1160 ----------------GQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK--- 1200

Query: 1678 LLKDELEKMKQLHRCPDL--SDFQQKI-SSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1734
             L+ ELE + Q H+   L  S+  Q +  S        L+ ++A ++ L   V  + +  
Sbjct: 1201 -LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQE-VRLVPQDR 1258

Query: 1735 LLE-HRIATMKQEQ--KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRV 1791
            + E HR+ +++ EQ  +  + Q    + QL A++E+V+  E  ++N+ + +      L+ 
Sbjct: 1259 VAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLK- 1317

Query: 1792 TQQEKEALKQEVMSLHKQLQNA 1813
             +Q ++  K +++     ++NA
Sbjct: 1318 -EQFEKNTKSDLLLKELYVENA 1338



 Score = 38.1 bits (87), Expect = 0.089
 Identities = 52/247 (21%), Positives = 108/247 (43%), Gaps = 25/247 (10%)

Query: 793  QRELQEGREKMET---ECNRRTSQIEAQFQSDCQKVTERCESALQSLE-GRYRQELKDLQ 848
            Q  +Q GRE +++     + + + +E  +  D + +T   +SA+Q      Y QEL    
Sbjct: 333  QEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMT--VDSAVQQAALACYHQELS--- 387

Query: 849  EQQREEKSQWEFEKDELTQECAEAQ----ELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
              Q+ +  Q   E+D+  Q+   A+    E +KE      T   +  ++ + LE+ Y+E 
Sbjct: 388  -YQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRER 446

Query: 905  L----NSMVVERQQLLQDLEDLRNVSE-------TQQSLLSDQILELKSSHKRELREREE 953
            L    + +  ER+   +     R   E        +++ L +++      + R  +E  E
Sbjct: 447  LSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVE 506

Query: 954  VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1013
            V+ +   SE+LA +  + LE     + +   ++LLA E    A  +  + +  ++     
Sbjct: 507  VVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRND 566

Query: 1014 RLQSKIK 1020
             LQ++++
Sbjct: 567  ELQAELE 573



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 74/355 (20%), Positives = 137/355 (38%), Gaps = 33/355 (9%)

Query: 1563 QENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1622
            QE +  Q  VE L ++  + +   ++ +  N E  ++       L++L ++  + L Q  
Sbjct: 384  QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGY 443

Query: 1623 KEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDE 1682
            +E  +    E E E+    E+  R +      V  L+AE + ++ +  +  +EN  L+ E
Sbjct: 444  RERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKE 503

Query: 1683 L----EKMKQLHRCP-----DLS-----DFQQKISSVLSYNEK---LLKEKEALSEELNS 1725
            +    EK+    R       DL        + + + +L+  E+   +LKE E    +L  
Sbjct: 504  IVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQD 563

Query: 1726 CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV----ASQEKVQNLEDTVQNVNLQ 1781
              D+L     LE   A + + + S        + QL     A    + N         L 
Sbjct: 564  RNDELQAE--LEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELM 621

Query: 1782 MSRMKS---DLRVTQQEK-EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1837
            M ++K    DLR   + K    ++E+ +L +  +    K          S L  Q+    
Sbjct: 622  MEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKER-KDMEQARRREVSVLEGQKA--- 677

Query: 1838 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1892
               L+ L  + Q+++W   E+LQ   +  + E         Q    L  +H  HL
Sbjct: 678  --DLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHL 730



 Score = 35.8 bits (81), Expect = 0.44
 Identities = 65/340 (19%), Positives = 134/340 (39%), Gaps = 55/340 (16%)

Query: 957  QAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD-------------- 1002
            Q    EQLA+      ++  ++E+ +M +KLL +E++ +A  +  D              
Sbjct: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSE 1091

Query: 1003 ----------RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALS- 1051
                      R R E+    S   ++ KE++          S  +V+  +       LS 
Sbjct: 1092 ENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQ 1151

Query: 1052 ----LLQQGEQLL------EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE-- 1099
                +LQ G++        EE+   +  L ++ E+ V+   + + +I +L+  L+ L   
Sbjct: 1152 LNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQE 1211

Query: 1100 ------PGLVMSSCLDEPATEFFG---NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1150
                  P   ++  L+E   +  G      +     LQ+ R    + V   H L  L+ +
Sbjct: 1212 HQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGE 1271

Query: 1151 EVRDLGSTGTSSVQRQ----EVKIEESEASVEGFSE-LENSEETRTESWELKNQISQLQE 1205
            + R          ++Q    E ++EE+E  ++     L+   +   E +E   +   L +
Sbjct: 1272 QARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLK 1331

Query: 1206 QLMMLCADCDRA----SEKKQDLLFDVSVLKKKLKMLERI 1241
            +L +  A   RA     EK++       +L++K++ L ++
Sbjct: 1332 ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKL 1371



 Score = 35.8 bits (81), Expect = 0.44
 Identities = 50/220 (22%), Positives = 98/220 (44%), Gaps = 36/220 (16%)

Query: 356  SIHQAALASFKAEIRHLLERVDQVVR-------EKEKLRSDLD------------KAEKL 396
            S HQA     +  I+ L + +++VVR       + +KLR +L+             +E  
Sbjct: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223

Query: 397  KSLMAS--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 454
            ++L  S  +V   H  + +    +L+++    ++R+A L   L  + EQ  ++   QR E
Sbjct: 1224 QTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREE 1283

Query: 455  LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAE 514
             E++++   TEE      + L       +E  L E  +KL E      + ++N ++ L  
Sbjct: 1284 HEKQLK--ATEERVEEAEMIL-----KNMEMLLQEKVDKLKE------QFEKNTKSDLLL 1330

Query: 515  KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 554
            K  +L   +A      +   + +   E+Q R+L+++V  L
Sbjct: 1331 K--ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRAL 1368


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  206 bits (524), Expect = 2e-52
 Identities = 371/1710 (21%), Positives = 712/1710 (41%), Gaps = 261/1710 (15%)

Query: 387  RSDLDKAEKLKSLMASEVDDHHAAIERR-NEYNLRKLDEEYKERIAALKNEL------RK 439
            + DL K  K + ++  +       +E+   E   + + E   + I AL   L      + 
Sbjct: 27   KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86

Query: 440  EREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS----LKENSRLENELLENAEKLA 495
            E EQ      K+ ++++QE+E + T+       L  S    +KE   L+NEL+    K +
Sbjct: 87   ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146

Query: 496  EYE-NLTNKLQR--NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 552
            E + NL  +L+   N +  L+E+    + S       +E + ++R  +E Q   LQ Q+D
Sbjct: 147  EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206

Query: 553  ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612
                E +E   Q       L+N     +EANS   +               S++ EL+  
Sbjct: 207  ATTDEKKETVTQ-------LQNI----IEANSQHYQKNIN-----------SLQEELL-- 242

Query: 613  QMKEQHHRDICCLRLELEDKVRHYEKQL-------DETVVSCKKAQENMKQRHENETHTL 665
            Q+K  H  ++  L  ++E   + +E ++       +  V  C+ +++N+++++E E   L
Sbjct: 243  QLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL 302

Query: 666  EKQISDLK--NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQH 723
             K  S+    N+I  +  Q     E       +H E+  +   +LE + + L++++   +
Sbjct: 303  RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK---ELESQHSILKDEVTYMN 359

Query: 724  EMELKARL--TQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 781
             ++LK  +     +  F  ERE L      E K+  L        +E+   ++EK   E 
Sbjct: 360  NLKLKLEMDAQHIKDEFFHEREDL------EFKINELL-----LAKEEQGCVIEKLKSEL 408

Query: 782  EELRKEL---LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 838
              L K+    +E+H RE+Q  +E+ + E     S++   F SD +K        +Q L  
Sbjct: 409  AGLNKQFCYTVEQHNREVQSLKEQHQKE----ISELNETFLSDSEKEKLTLMFEIQGL-- 462

Query: 839  RYRQELKDLQEQQREEKSQWEFEKD--ELTQ-ECAEAQELLK---ETLKREKTTSLVLTQ 892
              +++ ++LQ++++E    +E  ++  E+ Q E  E+   +    E++K+++ + +   Q
Sbjct: 463  --KEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520

Query: 893  EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL--ELKSSHKRELRE 950
            ++          L +   E+  LL+ +  L+  +E    LLS Q L  EL+++ K  L+E
Sbjct: 521  QK----------LRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIK-NLQE 566

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL----AMENIHKATCETADRERA 1006
            +  V   + +      + LE       +E+ + ++KL      M+N HK  CE  +R   
Sbjct: 567  KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK-KCEREERLIL 625

Query: 1007 EMSTEISR------------------LQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGD 1047
            E+  ++ +                  L+  +KE  Q    L  L    +V+ E+ EV   
Sbjct: 626  ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685

Query: 1048 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL--EPGLVMS 1105
               SL ++  +L  E   +   L+    Q  KE+V +   I++L+++LQ +  E   +  
Sbjct: 686  EVKSLYEENNKLSSEKKQLSRDLEVFLSQ--KEDVILKEHITQLEKKLQLMVEEQDNLNK 743

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
               +E   + F  T  Q   FL++  ++  E           E D V  L + G S  + 
Sbjct: 744  LLENEQVQKLFVKT--QLYGFLKEMGSEVSE--------DSEEKDVVNVLQAVGESLAKI 793

Query: 1166 QEVKIEESEASVEGFSELEN-----SEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1220
             E K   +    E   ELE       EE+  +  ELK+ +   +++ ++L  + +    +
Sbjct: 794  NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853

Query: 1221 KQDLLFDVSVLKKK-----------LKMLERIPEASPKYKLLYEDVS---RENDCLQEEL 1266
            K+ L  D+  +K             L  +E + +   K ++  E      +E++ L+  L
Sbjct: 854  KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913

Query: 1267 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIEN-------- 1318
               E R         +  AE+  L+D L K   V    LS  K  +E KIEN        
Sbjct: 914  EQKELR---------DRRAELILLKDSLAKSPSVKNDPLSSVKELEE-KIENLEKECKEK 963

Query: 1319 -EELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRV 1377
             E++N + L      ++L  S   R +    +  LE+L  E D    QL+ ++ + +   
Sbjct: 964  EEKINKIKLVAVKAKKELDSS---RKETQTVKEELESLRSEKD----QLSASMRDLIQGA 1016

Query: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI------- 1430
             S  +++ E +++++ L+     +EK +A+        +        +Q + I       
Sbjct: 1017 ESYKNLLLEYEKQSEQLD-----VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071

Query: 1431 ------LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSH 1484
                  L+ N  LL  Q    Q    + + ELE  KLQ+  +K+KE  T + + +++   
Sbjct: 1072 LARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK-EQKIKEHATTVNELEELQVQ 1130

Query: 1485 GEKE-EELKAMMHDLQITCSEMQQ----KVELLRYE--SEKLQQENSILRNEITTLNEED 1537
             +KE ++L+  M +L++   + QQ     +E+  YE   ++L Q+ +   N+I  L +E 
Sbjct: 1131 LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEI 1190

Query: 1538 SISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1597
             I   K  TL      +    +  +++N  +++++   KK++++ K       +    L 
Sbjct: 1191 KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLK 1250

Query: 1598 QKNSQNQEKLQELNQRLTEMLCQKEK---------EPGNSALEEREQEKFNLKEELERCK 1648
             +   +Q++++    +L E+  +K K         E     L   +Q    L+EE    K
Sbjct: 1251 GELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAK 1310

Query: 1649 VQSSTLVSSLEAELSEVKIQTHIVQQENHLL--------KDELEKMKQL--HRCPDLSDF 1698
             + +T+ S  E E  +V++   + QQ+N  +        K E E ++ L       L D 
Sbjct: 1311 AEQATVTS--EFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDS 1368

Query: 1699 QQKISSVLSYNEKLLKEKEALSEELNSCV-DKLAKSSLLEHRIATMKQEQKSWEHQSASL 1757
            Q  +   +S  + L  E + L E  N  + + ++K + L  ++ +++ E    + +    
Sbjct: 1369 QNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQT 1428

Query: 1758 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1817
             SQL +  E ++N      +   Q+  ++ + R T    E L+Q++  +  QL     + 
Sbjct: 1429 VSQLTSQNEVLRN------SFRDQVRHLQEEHRKT---VETLQQQLSKMEAQLFQLKNEP 1479

Query: 1818 WAPEIATHPSGLHNQQKRLSWD--KLD-HLMNEEQQLLWQENERLQTMVQNTKAELTHSR 1874
                  +    L N ++R + D   LD H +  E      E E ++T    T  E   S 
Sbjct: 1480 TTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE------EGEGMET----TDTESVSSA 1529

Query: 1875 EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQ 1934
                Q    LL   +  L P        +E+L  K          S   +    +N L +
Sbjct: 1530 STYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQK---------LSSTTKSADHLNGLLR 1580

Query: 1935 ELE---TIHLENEGLKKKQVKLDEQLMEMQ 1961
            E E    I +E   L K +++  E+  E +
Sbjct: 1581 ETEATNAILMEQIKLLKSEIRRLERNQERE 1610



 Score =  122 bits (307), Expect = 3e-27
 Identities = 260/1339 (19%), Positives = 537/1339 (40%), Gaps = 180/1339 (13%)

Query: 348  NELLVTKNSIHQAALASFKAEIRHLLER----VDQVVREKEKLRSD------------LD 391
            NELL+ K       +   K+E+  L ++    V+Q  RE + L+              L 
Sbjct: 388  NELLLAKEE-QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLS 446

Query: 392  KAEKLKSLMASEVDDHHAAIERR---------NEYNLRKLDEEYKERIAALKNELRKERE 442
             +EK K  +  E+       E           N  +LR++ E  +  +     ++ +E E
Sbjct: 447  DSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE 506

Query: 443  QILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTN 502
             + QQ      EL+Q++  A TE++ + + +     EN +    LL   E + E EN   
Sbjct: 507  SMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEK----LLSQQELVPELENTIK 562

Query: 503  KLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR 562
             LQ     V        D    E   +   LT+ ++++  + +   +++D    + E   
Sbjct: 563  NLQEK-NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE 621

Query: 563  AQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDI 622
                 L L L     + ++ NS   E E     ++ N L   +E     E +KE+   D 
Sbjct: 622  R----LILELGKKVEQTIQYNS---ELE-----QKVNELTGGLE-----ETLKEKDQNDQ 664

Query: 623  CCLRLELEDKVRHYEKQLDETVVSC------KKAQENMKQRHENETHTLEKQISDLKNEI 676
               +L ++ KV   +K++    V        K + E  +   + E    +K+   LK  I
Sbjct: 665  KLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHI 724

Query: 677  AELQGQAAVLKEAHHEATCRHEEE-------KKQLQVKLEEEKTHLQEKLRLQHEMELKA 729
             +L+ +  ++ E         E E       K QL   L+E  + + E    +  + +  
Sbjct: 725  TQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQ 784

Query: 730  RLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE-KHTLEKEELRKEL 788
             + ++ A    E+  L  +   +EKV  L +E++   +E +    E K  L   E  K L
Sbjct: 785  AVGESLAKINEEKCNL--AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL 842

Query: 789  LEKHQRELQEGREKMETE------CNRRTSQIEAQFQSDCQKVTERCESALQSLEG---- 838
            L K   E+Q  +E ++++       N +T           ++V++ C  +    E     
Sbjct: 843  LRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCF 902

Query: 839  -RYRQELKDLQEQQ--REEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQERE 895
             +  + LK L EQ+  R+ +++    KD L +  +   + L    + E+    +  + +E
Sbjct: 903  IKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKE 962

Query: 896  MLEK---------TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKR 946
              EK           K+ L+S   E Q + ++LE LR+  +   + + D +++   S+K 
Sbjct: 963  KEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRD-LIQGAESYKN 1021

Query: 947  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1006
             L E E+       SEQL  ++      EH   R E +++ L    +    CET + +  
Sbjct: 1022 LLLEYEK------QSEQLDVEKERANNFEH---RIEDLTRQLRNSTLQ---CETINSDNE 1069

Query: 1007 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1066
            ++   I  LQS  K ++     L + ++   V  E E E         Q EQ ++E+   
Sbjct: 1070 DLLARIETLQSNAKLLE--VQILEVQRAKAMVDKELEAE-------KLQKEQKIKEHATT 1120

Query: 1067 LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPF 1126
            +  L+    Q  KE      ++ +  Q L+ ++     ++ ++    ++     E  +  
Sbjct: 1121 VNELEELQVQLQKEK----KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKL 1176

Query: 1127 LQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK-IEESEASVEGFSELEN 1185
               N+  ++E + +   +   + + +++  ++  SSVQ+ E K  +  +  V+   EL +
Sbjct: 1177 --TNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD 1234

Query: 1186 SEETRTE----SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERI 1241
            S++  T+       LK ++   Q+Q+ +                    +  +K K+ E +
Sbjct: 1235 SKQAETDHLILQASLKGELEASQQQVEVYKIQL-------------AEITSEKHKIHEHL 1281

Query: 1242 PEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT 1301
              ++ +++       +    LQEE R  +    E      E  +   R+ + LK+ +  +
Sbjct: 1282 KTSAEQHQRTLSAYQQRVTALQEECRAAKA---EQATVTSEFESYKVRVHNVLKQQKNKS 1338

Query: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1361
             +    +   +  K E E L +L+ +L+ K++  Q ++       +  + L+ L+ E D 
Sbjct: 1339 MS----QAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ------INVSELQTLQSEHDT 1388

Query: 1362 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTIQTHQ 1420
             + + N+ L+E V +   +   +   + EN  ++  +TQ + ++          T Q   
Sbjct: 1389 LLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQL----------TSQNEV 1438

Query: 1421 ERPRVQNQVILEENTTLLGFQDKHFQ--HQATIAELELEKTKLQELTRKLKERVTIL--V 1476
             R   ++QV             +H Q  H+ T+  L+ + +K++    +LK   T    V
Sbjct: 1439 LRNSFRDQV-------------RHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485

Query: 1477 KQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE 1536
              +  L +  +       + D+     E  + +E    ++E +   ++  ++    LN  
Sbjct: 1486 SSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETT--DTESVSSASTYTQSLEQLLNSP 1543

Query: 1537 DSISNLKLGTLNGSQEEMWQK----TETVKQENAAVQKMVENLKKQISELK-IKNQQLDL 1591
            ++     L     ++EE+ QK    T++    N  +++        + ++K +K++   L
Sbjct: 1544 ETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRL 1603

Query: 1592 ENTELSQKNSQNQEKLQEL 1610
            E  +  +K++ N E L+ +
Sbjct: 1604 ERNQEREKSAANLEYLKNV 1622



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 167/758 (22%), Positives = 328/758 (43%), Gaps = 137/758 (18%)

Query: 341  ELTLALENEL-LVTKNSIHQ-----AALASFKAEIRHLLERVDQVVREKEKLRSDLDKAE 394
            E  L LE E+  + + S+ Q     + L  ++ E   L + ++++  EKE L+SDL    
Sbjct: 806  EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDL---- 861

Query: 395  KLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 454
             L+   A+E         R    NL    EE  +  +  K+E+  E+E+   +       
Sbjct: 862  -LEMKNANEK-------TRLENQNLLIQVEEVSQTCS--KSEIHNEKEKCFIK------- 904

Query: 455  LEQEIEKAKTEENYIRDRLA-LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLA 513
             E E  K   E+  +RDR A L L ++S  ++  ++N + L+  + L  K++ NLE    
Sbjct: 905  -EHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN-DPLSSVKELEEKIE-NLEKECK 961

Query: 514  EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLK 573
            EK   ++         ++ L   R E     + ++++++ L+SE ++  A  R L   ++
Sbjct: 962  EKEEKINKIKLVAVKAKKELDSSRKE----TQTVKEELESLRSEKDQLSASMRDL---IQ 1014

Query: 574  NSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKV 633
             + S +                      N+ +E E   EQ+  +  R         E ++
Sbjct: 1015 GAESYK----------------------NLLLEYEKQSEQLDVEKER-----ANNFEHRI 1047

Query: 634  RHYEKQLDETVVSCK---KAQENMKQRHENETHTLEKQISDLKNEIAELQ-GQAAVLKEA 689
                +QL  + + C+      E++  R E    TL+     L+ +I E+Q  +A V KE 
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIE----TLQSNAKLLEVQILEVQRAKAMVDKEL 1103

Query: 690  HHEATCRHEE---------EKKQLQVKLEEEKTHLQEKLR----LQHEMELKARLTQAQA 736
              E   + ++         E ++LQV+L++EK  LQ+ ++    ++ + +    +    A
Sbjct: 1104 EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIA 1163

Query: 737  SFEREREGL-QSSAWTEEKVRGLTQEL------EQFHQEQLTSL---VEKHTLEKEELRK 786
             +ER  + L Q       K+  L QE+      ++  QE++TSL   V+++  EK    K
Sbjct: 1164 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYE-EKNTKIK 1222

Query: 787  ELLEKHQRELQEGRE----------KMETECNRRTSQIE------AQFQSDCQKVTERCE 830
            +LL K ++EL + ++           ++ E      Q+E      A+  S+  K+ E  +
Sbjct: 1223 QLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK 1282

Query: 831  SALQSLE---GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTS 887
            ++ +  +     Y+Q +  LQE+ R  K+    E+  +T E    +  +   LK++K  S
Sbjct: 1283 TSAEQHQRTLSAYQQRVTALQEECRAAKA----EQATVTSEFESYKVRVHNVLKQQKNKS 1338

Query: 888  LVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE 947
              ++Q      K  +EHL  ++ + +  LQD ++   ++ ++   L  +   L   H + 
Sbjct: 1339 --MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKM 1396

Query: 948  LRER-------EEVLCQAGASEQLA----SQRLERLEMEHDQERQEMMSKLLAMENIHKA 996
            L+E         E LC   +   +     +Q + +L  +++  R     ++  ++  H+ 
Sbjct: 1397 LQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK 1456

Query: 997  TCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1034
            T ET  ++ ++M  ++ +L    K      SP+S  QS
Sbjct: 1457 TVETLQQQLSKMEAQLFQL----KNEPTTRSPVSSQQS 1490


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  204 bits (518), Expect = 9e-52
 Identities = 391/1873 (20%), Positives = 778/1873 (41%), Gaps = 284/1873 (15%)

Query: 351  LVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAA 410
            L ++  + +A L     E+  LL +  +   + EK+   L +  ++     +E+ +H A+
Sbjct: 270  LKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS 329

Query: 411  IERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQR-LELEQEIEKAKTEENYI 469
            + R  +     L +  K+    +   + +E + I Q +G +  LEL+  I    ++ +Y 
Sbjct: 330  LSRNAQEEKLSLQQVIKD----ITQVMVEEGDNIAQGSGHENSLELDSSI---FSQFDYQ 382

Query: 470  RDRLALSLKEN--SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF 527
                AL+L  +  +R    + +  ++LA  +   N LQ        ++    +       
Sbjct: 383  DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ--------QQHDQWEEEGKALR 434

Query: 528  LQEERLTQMRNEYERQCRVLQDQVDELQSE-------LEEYRAQGRVLRLPLKNSPSEEV 580
             + ++LT  R+    Q   LQ +VD L  E        EE R Q  VL           V
Sbjct: 435  QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494

Query: 581  EANSGGIEPEHGLGSEECNPLNMSI-------EAELVIEQMKEQHHRDICCLRLELEDKV 633
            E    G +   G   E+   L++++       E  + +E  + +   ++  LR  LE   
Sbjct: 495  ELQLQG-DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESS- 552

Query: 634  RHYEKQL-----DETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ-------- 680
             H E +L      E   +  +A++++ +   +E +TL+ +++DL+    +L         
Sbjct: 553  -HLEGELLRQEQTEVTAALARAEQSIAELSSSE-NTLKTEVADLRAAAVKLSALNEALAL 610

Query: 681  -----GQAAVLKEAHHEATCRH----EEEKKQLQVKLE----------EEKTHLQEKLRL 721
                  Q  +  E  +++ C      E+ +  LQV L           E+ THL+ +L+ 
Sbjct: 611  DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670

Query: 722  QHE--MELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ-------LTS 772
              E   EL+A L   Q   E  ++ L  S   +E     T +LEQ HQE          +
Sbjct: 671  AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE---AATTQLEQLHQEAKRQEEVLARA 727

Query: 773  LVEKHTLEKE----ELRKELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTE 827
            + EK  L +E    E+R + +E+ +++L E  + + +      +S  EAQ Q+   +VT+
Sbjct: 728  VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787

Query: 828  -RCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 883
             + E  +Q++   +   + E++ L+ +   E+SQ E E+D   ++ A+A++  K  L+++
Sbjct: 788  GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847

Query: 884  KTT-SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKS 942
            K      + Q RE  EK    H       +Q+L + LE L             + +EL+ 
Sbjct: 848  KAAHEKEVNQLREKWEKERSWH-------QQELAKALESLER-----------EKMELEM 889

Query: 943  SHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD 1002
              K +  E E +  Q       A   L ++++E ++ER  ++  LL  +       +  +
Sbjct: 890  RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949

Query: 1003 RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE-EEVEGDGALSLLQQGEQLLE 1061
            R R +M  +      K+KE +      + LQ   + + E      D   +L ++   LL+
Sbjct: 950  RLRQDMKVQ------KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003

Query: 1062 ENGDVLLSL-------------QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS--- 1105
            +  D+   +             QR  EQ V+E ++   E +R+Q+ L++ +  L +S   
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063

Query: 1106 -------------------SCLDEPATEFFGNTAE---QTEPFLQQNRTKQVEGVTRR-H 1142
                               S L +   E  G   E   Q E   Q+ + K+ + + +   
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123

Query: 1143 VLSDLEDDEVRD------LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWEL 1196
            +L +LE   + +      L +    + Q Q +++  +E+ +E  +  +          +L
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQLEALAAEQQPGNQAQAQAQL 1182

Query: 1197 KNQISQLQEQLMMLCADCDRAS------------EKKQDLLFDVSVLKKKLKMLERIPEA 1244
             +  S LQ+ L  +C      S            E  Q+    +      L  L     A
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 1245 SPKYKLLYEDV---SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL------- 1294
            S  +K L++D+    +  D L+++++ +E R  +      ++  E+  LQ +L       
Sbjct: 1243 SALHK-LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301

Query: 1295 -----------KKMEEVTETFLSLEKSYDEVKI-------ENEELNVLVLRLQGKIEKLQ 1336
                        ++ E+ ET  SL+      ++       E E L      L  ++E LQ
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361

Query: 1337 ESVVQRCDCCLWEASLENLEIEPDGNILQL-NQTLEECVPRVRSVHHVIEECKQENQYLE 1395
             +VV+          LE  ++    + L+L N+ +E    R +++    E    + + L+
Sbjct: 1362 AAVVEARAQASAAGILEE-DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420

Query: 1396 GNTQLLEKVKA---HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1452
             N  LL +  A    E+  L G IQ  +++  +Q   +   +  L     +    Q  I 
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
            ELE  ++ L+ L   ++ER   L  Q++ +   EK+ E +  + + Q+   E+++K +++
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL--ELEKKDQMI 1538

Query: 1513 RYESEKLQQ-ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ-ENAAVQK 1570
              +  ++Q  +  ++  E   L  E++   ++       Q+++ ++ E  ++ +  A+  
Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKME------CQQKLIKELEGQRETQRVALTH 1592

Query: 1571 MVENLKKQISELKIKNQQL-DLE--NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGN 1627
            +  +L+++  EL+ ++ Q+ DLE  +T L+++  +  ++++   +++ E+  Q++KE   
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL--QRQKEHLT 1650

Query: 1628 SALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKI-----------QTHIVQQE- 1675
              LE R+QE    KE ++  + Q +     LE +L ++K+           Q  ++Q+  
Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710

Query: 1676 ------NHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDK 1729
                  +   +  LE MK +     L D ++++     +  +L + K+ L ++L     K
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLI-----LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765

Query: 1730 LAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL 1789
            + ++SLL      + Q     E +   L+ QL  ++E+ +  E ++Q+   Q+   +  L
Sbjct: 1766 VGETSLL------LSQR----EQEIVVLQQQLQEAREQGELKEQSLQS---QLDEAQRAL 1812

Query: 1790 RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH-----L 1844
                QE EAL+QE      Q +    K+ A + A   +  H   K    +  DH      
Sbjct: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA--HMTLKERHGELQDHKEQARR 1870

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKH-----------LN 1893
            + EE  +  +  + L+ ++ + +AE     + +  L+     + Q+H           L 
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930

Query: 1894 PSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKL 1953
                +   +QE  +L+ E  Q  + Q  A R  ++  +L++ L   H   +G  K+Q  L
Sbjct: 1931 AQAVLKERDQELEALRAE-SQSSRHQEEAAR--ARAEALQEALGKAHAALQG--KEQHLL 1985

Query: 1954 DEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE 2013
            ++  +      STAT   S  A      Q +      R Q  ++Q Q L+ +   Q LQ+
Sbjct: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQEGEIQDQDLRYQEDVQQLQQ 2042

Query: 2014 ELENRTSETNTPQ 2026
             L  R  E    Q
Sbjct: 2043 ALAQRDEELRHQQ 2055



 Score =  202 bits (515), Expect = 2e-51
 Identities = 389/1837 (21%), Positives = 763/1837 (41%), Gaps = 282/1837 (15%)

Query: 320  ENSQEILKALDF----SLDGNINLTELTLA--LENELLVTKNSIHQAALASFKAEIRHLL 373
            E  QE+L  L+     SL   I L E   +  LE ELL  + +   AALA  +  I  L 
Sbjct: 522  ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASE---VDDHHAAIERRNEYNLRKLD--EEYKE 428
               + +  E   LR+   K   L   +A +   ++     +E  N+    +++  E+ + 
Sbjct: 582  SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641

Query: 429  RIAALKNELRKEREQI----------LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLK 478
             +     E  K RE +          LQ+A +   EL+ ++   + E+  I+ +L+ S  
Sbjct: 642  ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701

Query: 479  ENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN 538
            +      +L +  ++    E +  +  +  E ++ EK        A   ++ + + + R 
Sbjct: 702  QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK--------AALEVRLQAVERDRQ 753

Query: 539  EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 598
            +   Q + L    + L+S L E + Q  V            +E   G +E          
Sbjct: 754  DLAEQLQGLSSAKELLESSLFEAQQQNSV------------IEVTKGQLE---------- 791

Query: 599  NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRH 658
                + I+    + Q KE    ++ CL+LEL+ +    E++ D       +A++  K   
Sbjct: 792  ----VQIQT---VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844

Query: 659  ENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ-- 716
            E +    EK+++ L+ +    + + +  ++   +A    E EK +L+++L+E++T ++  
Sbjct: 845  EQQKAAHEKEVNQLREK---WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901

Query: 717  EKLRLQHEMELKARLTQAQASFEREREGL-QSSAWTEEKVRGLTQELEQFHQEQLTSLVE 775
            +  R +   + ++ L Q Q   E+ER  L ++   T++++   +Q+LE+  Q+     ++
Sbjct: 902  QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961

Query: 776  KHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQS 835
            +   E   + +  L++ QREL+E                  Q + D   + E   S LQ 
Sbjct: 962  EQ--ETTGILQTQLQEAQRELKEAAR---------------QHRDDLAALQEESSSLLQ- 1003

Query: 836  LEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQERE 895
                   +  DLQ+Q  + KSQ   + D       E QE L+ET +  +    +   ERE
Sbjct: 1004 -------DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKEL---ERE 1053

Query: 896  MLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVL 955
                  K  L   ++E++Q L  L++  ++ + + S L   + E +   K EL  + E+L
Sbjct: 1054 ------KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK-ELSAQMELL 1106

Query: 956  CQAGASEQL-----ASQRLERLEMEHDQERQ-------------EMMSKLLAMENIHKAT 997
             Q    ++       +Q LE LE  H  E+Q             ++  +L + E+  +A 
Sbjct: 1107 RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL 1166

Query: 998  CETAD-----RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSL 1052
                      + +A++++  S LQ  +  + ++   LS        +   E + +GA SL
Sbjct: 1167 AAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSL 1226

Query: 1053 LQQGEQLLEENGDVLLS-LQRAHEQAVKENVKMATEISR--LQQRLQKLEPGLVMSSCLD 1109
             ++G  L   + + + S L + H+   K      T+ +R  L+ ++QKLE  L  +    
Sbjct: 1227 FKRGPLLTALSAEAVASALHKLHQDLWK------TQQTRDVLRDQVQKLEERLTDT---- 1276

Query: 1110 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1169
            E          +  +  L QN+ ++ +   +++ L    + E+ +L  T  +S+Q +  +
Sbjct: 1277 EAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL----ESELMELHET-MASLQSRLRR 1331

Query: 1170 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1229
             E      +G  EL  + +       L  Q+  LQ  ++   A    A   ++DL    S
Sbjct: 1332 AELQRMEAQGERELLQAAKEN-----LTAQVEHLQAAVVEARAQASAAGILEEDLRTARS 1386

Query: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289
             LK K + +E   E +   +   E    +   LQE L ++     E  E  + L  ++  
Sbjct: 1387 ALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQE 1446

Query: 1290 LQDELKKMEEVTETF-LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLW 1348
            L+ + +  +   E   L L+K   EV ++ E++  L  + +  +E L  +V +R      
Sbjct: 1447 LEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELE-KCRSVLEHLPMAVQER------ 1499

Query: 1349 EASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE 1408
                + L ++ +    Q+ +  ++   +   + H + E ++++Q +E     ++ +K   
Sbjct: 1500 ---EQKLTVQRE----QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552

Query: 1409 IAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKL 1468
            +      ++             LEEN   +  Q K  +      + E ++  L  LT  L
Sbjct: 1553 VTLECLALE-------------LEENHHKMECQQKLIKELE--GQRETQRVALTHLTLDL 1597

Query: 1469 KERVTILVKQK----DVLSHG--------EKEEELKAMMHDLQITCSEMQQKVELLRYES 1516
            +ER   L  Q     D+ SH         E+++E+K+    ++    E+Q++ E L  + 
Sbjct: 1598 EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE----ELQRQKEHLTQDL 1653

Query: 1517 EKLQQENSILRNEITTLNE---------EDSISNLKLGT------LNGSQEEMWQKTETV 1561
            E+  QE  + +  I  L +         E+ +  +KL        L   ++ M ++ E  
Sbjct: 1654 ERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEG 1713

Query: 1562 KQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQK 1621
            K  + A +  +E++K     L +++++ ++E  +      ++  +LQEL  +L + L   
Sbjct: 1714 KGPSKAQRGSLEHMK-----LILRDKEKEVECQQ------EHIHELQELKDQLEQQLQGL 1762

Query: 1622 EKEPGNSAL--EEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLL 1679
             ++ G ++L   +REQE   L+++L+  + Q      SL+++L E +       QE   L
Sbjct: 1763 HRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEAL 1822

Query: 1680 KDELEKMK-QLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE- 1737
            + E ++ + Q  R  + +D  Q     L      LKE+    ++      +L +   +E 
Sbjct: 1823 QQEQQQAQGQEERVKEKADALQ---GALEQAHMTLKERHGELQDHKEQARRLEEELAVEG 1879

Query: 1738 HRIATMKQEQKSWEHQSASLKSQLVASQEKV--QNLEDTVQNVNLQMSRMKSD--LRVTQ 1793
             R+  +++       +S   +  L+A Q++   Q  E  V+   LQ S +++   L+   
Sbjct: 1880 RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD 1939

Query: 1794 QEKEALKQEVMSLHKQLQNAGGKSWAPEIA---THPSGLHNQQKRLSWDKLDHLMN---- 1846
            QE EAL+ E  S   Q + A  ++ A + A    H +    +Q  L   +L   +     
Sbjct: 1940 QELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA 1999

Query: 1847 ---------------------------EEQQLLWQEN-ERLQTMVQNTKAELTHSREKVR 1878
                                       ++Q L +QE+ ++LQ  +     EL H +E+ +
Sbjct: 2000 TLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQ 2059

Query: 1879 QLESNLLPKHQKHLNPSGTMNPTEQEKLSLKR--------ECDQFQKEQSPAN-RKVSQM 1929
             LE +L  + Q+++         E+E+  ++         +    QKEQ     R+  Q 
Sbjct: 2060 LLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQR 2119

Query: 1930 NSLE---QELETIHLENEGLKKKQV--KLDEQLMEMQH-LRSTATPSPS--PHAWDL--Q 1979
            N+LE      +T  +E + LK   +  +L  +L  +Q  LR T          A DL   
Sbjct: 2120 NNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179

Query: 1980 LLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELE 2016
            L Q +A     +E  + LQ  +L+ +   Q LQ+ELE
Sbjct: 2180 LAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELE 2216



 Score =  202 bits (515), Expect = 2e-51
 Identities = 356/1733 (20%), Positives = 707/1733 (40%), Gaps = 269/1733 (15%)

Query: 347  ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 406
            E E LV + +  +  L + + + + L E++  +   KE L S L +A++  S++      
Sbjct: 730  EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789

Query: 407  HHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQ---AGKQRLELEQEIEKAK 463
                I+      + +  E  +  +  LK EL  ER Q  Q+   A +Q  + EQE + A 
Sbjct: 790  LEVQIQ-----TVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844

Query: 464  TEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSS 523
             ++    ++    L+E  + E E   + ++LA+      + +  LE  L E+  +++   
Sbjct: 845  EQQKAAHEKEVNQLRE--KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902

Query: 524  AEFFLQEER------LTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPS 577
            A+   +EER      L QM+ E E++   L + + + Q EL +   Q   LR  +K    
Sbjct: 903  AQ--REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960

Query: 578  EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCL----------RL 627
            +E E          G+   +        EA+  +++   QH  D+  L          ++
Sbjct: 961  KEQETT--------GILQTQLQ------EAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006

Query: 628  ELEDKVRHYEKQL----DETVVSCKKAQENMKQRHENET--HTLEKQISDLKNEIAELQG 681
            +L+ +V   + QL    D   +  ++ QE +++  E       LE++ + L   + E + 
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066

Query: 682  QAAVLKEA----HHEATCRHEE------EKKQLQVKLEEEKTHLQEKLR--LQHEMELKA 729
            +  VL+EA      E +   ++      E+K+L  ++E  +  ++EK    L  E +L  
Sbjct: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL-- 1124

Query: 730  RLTQAQASFEREREGLQSSAWTEE--------KVRGLTQELEQFHQEQ------------ 769
             L + +AS   E++ L++S W +E        ++R    +LE    EQ            
Sbjct: 1125 -LEELEASHITEQQ-LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182

Query: 770  --LTSLVEKHTLEKEELRKEL------------LEKHQRELQE-----------GREKME 804
              L S +++      E R EL            LE  Q   +              E + 
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 805  TECNR------RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQ---QREEK 855
            +  ++      +T Q     +   QK+ ER     ++ + +   EL+DLQ Q    +EEK
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDT-EAEKSQVHTELQDLQRQLSQNQEEK 1301

Query: 856  SQWEFEKDELTQECAEAQEL---LKETLKREKTTSLVLTQEREMLEKTYK------EHLN 906
            S+WE +++ L  E  E  E    L+  L+R +   +    ERE+L+   +      EHL 
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361

Query: 907  SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE--LREREEVLCQAGASEQL 964
            + VVE +        L     T +S L  +  E++S  +R   L+E+ E+    G + Q 
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421

Query: 965  ASQRLERLEMEHDQERQEMMSKLLAMEN---IHKATCETADRERAEMSTEISRLQSKIKE 1021
                L +   E ++E + +  ++  +E    + KA  E    +  + + E+   Q +I+E
Sbjct: 1422 NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481

Query: 1022 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1081
            +++  S L  L    Q       E +  L++ ++  + LE++ +   + +   E  + E 
Sbjct: 1482 LEKCRSVLEHLPMAVQ-------EREQKLTVQREQIRELEKDRE---TQRNVLEHQLLEL 1531

Query: 1082 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRR 1141
             K    I   + ++Q L+  LV   CL     E       Q +   +    ++ + V   
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591

Query: 1142 HVLSDLED---------DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTE 1192
            H+  DLE+          ++ DL S  T   +  + + +E ++  E   EL+  +E  T+
Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651

Query: 1193 SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1252
              E ++Q   LQ++ + +  D       +Q  + +  + + KL + ER  E + + +L+ 
Sbjct: 1652 DLERRDQELMLQKERIQVLED----QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQ 1707

Query: 1253 EDV------SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM-----EEVT 1301
            E        S+      E ++++    ++ +E  +E   E+  L+D+L++       +V 
Sbjct: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767

Query: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1361
            ET L L +   E+ +  ++L     R QG+++               E SL++   E   
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEA--REQGELK---------------EQSLQSQLDEAQR 1810

Query: 1362 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAH-EIAWLHGTIQTHQ 1420
             + Q +Q LE      +      E  K++   L+G  +     +AH  +   HG +Q H+
Sbjct: 1811 ALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE-----QAHMTLKERHGELQDHK 1865

Query: 1421 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKD 1480
            E+ R   + +  E   +   ++        + +L  E  + ++    L+++     ++ +
Sbjct: 1866 EQARRLEEELAVEGRRVQALEE-------VLGDLRAESREQEKALLALQQQCAEQAQEHE 1918

Query: 1481 VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSIS 1540
            V +   ++  L+A     Q    E  Q++E LR ES+  + +    R     L E    +
Sbjct: 1919 VETRALQDSWLQA-----QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973

Query: 1541 NLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN 1600
            +     L G ++ + ++ E  +   A+   +  +L    +  +   + L ++  E+  ++
Sbjct: 1974 H---AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQD 2030

Query: 1601 SQNQEKLQELNQRLT----EMLCQKEKEP------GNSALEEREQEKFNLKEELERCKVQ 1650
             + QE +Q+L Q L     E+  Q+E+E            E   QEK NL +E E  +++
Sbjct: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR 2090

Query: 1651 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE 1710
                 S  E +L+  + +  I++      ++ LE +   H+   + +   K+ S+     
Sbjct: 2091 GLHQ-SVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL---EP 2146

Query: 1711 KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQN 1770
            +L +E E L   L             E R    +++ +      A  K+ + + QE    
Sbjct: 2147 RLQRELERLQAALRQT----------EAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196

Query: 1771 LEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLHKQLQNAG------GKSWAPEI 1822
            L+ +V   + +  R++ +L +T++  EKE L     +   +L + G      G+    E 
Sbjct: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256

Query: 1823 ATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLES 1882
               P G+  Q  R    +L+HL     +L                           +++ 
Sbjct: 2257 EPSPDGMEKQSWR---QRLEHLQQAVARL---------------------------EIDR 2286

Query: 1883 NLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
            + L +H   L    T+   E+E+  LKRE  +  +  S    K +  +  +Q+
Sbjct: 2287 SRLQRHNVQLR--STLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337



 Score =  139 bits (351), Expect = 2e-32
 Identities = 327/1562 (20%), Positives = 642/1562 (41%), Gaps = 257/1562 (16%)

Query: 307  VERILDTWQEEGIENSQEILKALDF----SLDGNINLTE-------LTLALENELLVTKN 355
            V ++ + W++E   + QE+ KAL+      ++  + L E       +    E E    ++
Sbjct: 855  VNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914

Query: 356  SIHQAALASFKAEIRHLLERVDQVVRE-------KEKLRSDLDKAEKLK-----SLMASE 403
            ++ Q  L + K  +  LLE + Q  +E        E+LR D+ K +KLK      ++ ++
Sbjct: 915  ALCQMQLETEKERV-SLLETLLQTQKELADASQQLERLRQDM-KVQKLKEQETTGILQTQ 972

Query: 404  VDDHHAAIE---RRNEYNLRKLDEEYKERI---AALKNELRKEREQILQQAGKQRLELEQ 457
            + +    ++   R++  +L  L EE    +     L+ ++   + Q++ Q   QRL +EQ
Sbjct: 973  LQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL-VEQ 1031

Query: 458  EI-EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENV---LA 513
            E+ EK +  + Y R +  L  +E + L   L+E  ++L   +   +  Q+ L  +   + 
Sbjct: 1032 EVQEKLRETQEYNRIQKELE-REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQ 1090

Query: 514  EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD-------ELQSELEEYRAQGR 566
            E  G+    SA+  L  + + +   ++  Q   L ++++       +L++ L    A+  
Sbjct: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA 1150

Query: 567  VLRLPLKNS------------PSEEVEANS------------------------------ 584
             L+L L+++            P  + +A +                              
Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA 1210

Query: 585  ---GGIEPEHGLGSE--ECNPLNMSIEAELVIEQM--------KEQHHRDICCLRLELED 631
                G+EP+        +  PL  ++ AE V   +        K Q  RD+      L D
Sbjct: 1211 PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV------LRD 1264

Query: 632  KVRHYEKQLDETVVSCKKAQ---------------ENMKQRHENETHTLEKQISDLKNEI 676
            +V+  E++L +T    +K+Q               +  K + E + ++LE ++ +L   +
Sbjct: 1265 QVQKLEERLTDT--EAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322

Query: 677  A--------------ELQGQAAVLKEAHHEATCRHE-------EEKKQLQVK--LEEEKT 713
            A              E QG+  +L+ A    T + E       E + Q      LEE+  
Sbjct: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLR 1382

Query: 714  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 773
              +  L+L++E E+++   +AQA  E+    +      +E +  LTQ L +  +E  T  
Sbjct: 1383 TARSALKLKNE-EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441

Query: 774  VEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESA 832
             +   LEK+ E++K  LE    +L++  ++++ +      Q + Q    C+ V E    A
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ------QEQIQELEKCRSVLEHLPMA 1495

Query: 833  LQSLEGR---YRQELKDLQEQQREEKSQWEFEKDELTQ--ECAEAQELLKETLKREKTTS 887
            +Q  E +    R+++++L++ +  +++  E +  EL +  +  E+Q    + LK++  T 
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL 1555

Query: 888  LVLTQE-------REMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILEL 940
              L  E        E  +K  KE       +R  L     DL   S+  Q+  S QI +L
Sbjct: 1556 ECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA-QSSQIHDL 1614

Query: 941  KSSH---KRELRER-EEVLCQAGASEQLASQRLERLEMEHDQERQEMM------------ 984
            +S      REL+ER +EV  Q    E+L  Q+ E L  + ++  QE+M            
Sbjct: 1615 ESHSTVLARELQERDQEVKSQREQIEELQRQK-EHLTQDLERRDQELMLQKERIQVLEDQ 1673

Query: 985  ----SKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ-QATSPLSMLQSGCQVI 1039
                +K+L  E++ +      +R R E++T+   +Q + +E +  + +    L+    ++
Sbjct: 1674 RTRQTKILE-EDLEQIKLSLRERGR-ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731

Query: 1040 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL- 1098
             ++E E +     + + ++L ++    L  L R   +      +   EI  LQQ+LQ+  
Sbjct: 1732 RDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAR 1791

Query: 1099 EPGLVMSSCLDEPATEFFGNTAEQTEPF--LQQNRTKQVEGVTRR------HVLSDLEDD 1150
            E G +    L     E     A++ +    LQQ + +Q +G   R       +   LE  
Sbjct: 1792 EQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQ-QQAQGQEERVKEKADALQGALEQA 1850

Query: 1151 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEET----RTESWELKNQISQLQEQ 1206
             +      G     +++ +  E E +VEG   ++  EE     R ES E +  +  LQ+Q
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEG-RRVQALEEVLGDLRAESREQEKALLALQQQ 1909

Query: 1207 LMMLCADCDRASEKKQDLLFD-----VSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
                CA+  +  E +   L D      +VLK++ + LE +   S   +   E      + 
Sbjct: 1910 ----CAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA 1965

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSY-----DEVKI 1316
            LQE L     +   AL+  ++   E   L   L+      +  L   +++     + ++I
Sbjct: 1966 LQEAL----GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021

Query: 1317 ENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLE-----NLEIEPDGNILQLNQTL- 1370
            +  E+    LR Q  +++LQ+++ QR +    +   E     +L      N++Q  Q L 
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLG 2081

Query: 1371 -EECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH--QERPRVQN 1427
             E     +R +H  + E            QL    K  EI  L  T Q +  +  P    
Sbjct: 2082 QEREEEEIRGLHQSVRE-----------LQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130

Query: 1428 QVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKER---VTILVKQKDVLSH 1484
               +EE +  L   +   Q +    +  L +T+ +E+  + K +   +++   +  V S 
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190

Query: 1485 GEKEEELKAMMHDLQITCSEMQQKVELLR--YESEKLQQENSILRNEITTLNEEDSISNL 1542
             E    L+A + +       +Q ++EL R   E E+L    +    E+ +  E+     +
Sbjct: 2191 QEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQ----GV 2246

Query: 1543 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1602
            +LG ++G + E          E  + ++ +E+L++ ++ L+I   +L   N +L     Q
Sbjct: 2247 QLGEVSGVEAE----PSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302

Query: 1603 NQEKLQELNQRLTEMLCQKEKEPGN-SALEEREQEKFNLKEELERCKVQSSTLVSSLEAE 1661
             + + ++L +           E    +A    +Q+    K    +C  +    V  L+A+
Sbjct: 2303 VERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQ 2362

Query: 1662 LS 1663
            L+
Sbjct: 2363 LT 2364



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 171/794 (21%), Positives = 340/794 (42%), Gaps = 109/794 (13%)

Query: 1275 EALENNKELTAEVFRLQDELKKME---EVTETFLSLEKSYDEVKIENEELNVLVLRLQGK 1331
            EA E ++EL     + Q +L+K E    VTE    L +S  +    NE+   ++  L+  
Sbjct: 259  EAHERSQELIQ--LKSQGDLEKAELQDRVTELSALLTQSQKQ----NEDYEKMIKALRET 312

Query: 1332 IEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1391
            +E L+ +  +  +    EASL     E   ++ Q+ + + + +  V    ++ +    EN
Sbjct: 313  VEILETNHTELME---HEASLSRNAQEEKLSLQQVIKDITQVM--VEEGDNIAQGSGHEN 367

Query: 1392 QYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATI 1451
              LE ++ +  +    +       +++   R R   Q + +    L G Q+        +
Sbjct: 368  S-LELDSSIFSQFDYQDADKALTLVRSVLTRRR---QAVQDLRQQLAGCQE-------AV 416

Query: 1452 AELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVEL 1511
              L+ +  + +E  + L++R+  L  ++D L+             DLQ     + ++ EL
Sbjct: 417  NLLQQQHDQWEEEGKALRQRLQKLTGERDTLA---------GQTVDLQGEVDSLSKEREL 467

Query: 1512 LRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKM 1571
            L+   E+L+Q+  +L  E   L   +    L+  +  G +EE  ++     +E   +Q+M
Sbjct: 468  LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527

Query: 1572 VENLK----KQISEL----------KIKNQQLDLENTELSQKNSQNQEKLQEL----NQR 1613
            +  L+    + +SEL           ++ + L  E TE++   ++ ++ + EL    N  
Sbjct: 528  LMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587

Query: 1614 LTEMLCQKEKEPGNSALEER-EQEKFNLKEELERCKVQSSTLVSSLEA----------EL 1662
             TE+   +      SAL E    +K  L ++L + + ++ ++ S +EA          +L
Sbjct: 588  KTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDL 647

Query: 1663 SEVKIQTHIVQQENHLLKDELEKMKQ--LHRCPDLSDFQQKISSVLSYNEKLLKEKEALS 1720
            +E + +   + ++N  L+ +L+K ++       DL D Q++   +    +K L E     
Sbjct: 648  AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI----QKKLSESRHQQ 703

Query: 1721 EELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN 1779
            E   + +++L  ++   E  +A   QE+++   + A+L+ +L A +   Q+L + +Q ++
Sbjct: 704  EAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS 763

Query: 1780 LQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGG---------KSWAPEIATHPSGLH 1830
                 ++S L   QQ+   ++     L  Q+Q             +    E+ T  S   
Sbjct: 764  SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823

Query: 1831 NQQ----KRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP 1886
             ++    ++L+  + +     EQQ    E E  Q   +  K    H +E  + LES  L 
Sbjct: 824  QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALES--LE 881

Query: 1887 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
            + +  L        TE E +  +RE     +E++ A   + QM  LE E E + L  E L
Sbjct: 882  REKMELEMRLKEQQTEMEAIQAQRE-----EERTQAESALCQM-QLETEKERVSL-LETL 934

Query: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
             + Q +L +   +++ LR             +Q L++Q    + + Q  + QR+L +A R
Sbjct: 935  LQTQKELADASQQLERLRQD---------MKVQKLKEQETTGILQTQLQEAQRELKEAAR 985

Query: 2007 INQH------LQEE 2014
              QH      LQEE
Sbjct: 986  --QHRDDLAALQEE 997



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 104/534 (19%), Positives = 204/534 (38%), Gaps = 73/534 (13%)

Query: 1550 SQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQE 1609
            +Q   W+K +  ++       +V  L+ ++ + +   Q+L+           Q  E ++E
Sbjct: 34   NQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEE 93

Query: 1610 LNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEA--------- 1660
             N  L E+L + E+E      E   +    L+  +E+  V +  L   +E          
Sbjct: 94   PN--LDELLVRLEEE--QQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRAR 149

Query: 1661 -ELSEVKIQTHIVQQE-NHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1718
             EL   + Q  + Q+     LK E  ++  L R  ++  F++    + S  ++ L E +A
Sbjct: 150  DELMRKESQWQMEQEFFKGYLKGEHGRLLSLWR--EVVTFRRHFLEMKSATDRDLMELKA 207

Query: 1719 ----LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDT 1774
                LS  L +C  +L         +    +E            +QL+    K Q LE  
Sbjct: 208  EHVRLSGSLLTCCLRLT--------VGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKE 259

Query: 1775 VQNVNLQMSRMKS--DLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAP------------ 1820
                + ++ ++KS  DL   + +    +   +    Q QN   +                
Sbjct: 260  AHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETN 319

Query: 1821 --EIATHPSGLHN--QQKRLSWDKLDHLMNEEQQLLWQENERL-QTMVQNTKAELTHS-- 1873
              E+  H + L    Q+++LS   L  ++ +  Q++ +E + + Q        EL  S  
Sbjct: 320  HTELMEHEASLSRNAQEEKLS---LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIF 376

Query: 1874 -------REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSL-KRECDQFQKEQSPANRK 1925
                    +K   L  ++L + ++ +          QE ++L +++ DQ+++E       
Sbjct: 377  SQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGK----- 431

Query: 1926 VSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQA 1985
                 +L Q L+ +  E + L  + V L  ++  +   R     +       L++L+Q+A
Sbjct: 432  -----ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEA 486

Query: 1986 CPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQALLPEQRAVHADS 2039
              +      LQLQ    Q ++  Q  QEEL     E    Q +L    A  ++S
Sbjct: 487  WRLRRVNVELQLQGDSAQGQKEEQ--QEELHLAVRERERLQEMLMGLEAKQSES 538


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  203 bits (516), Expect = 2e-51
 Identities = 371/1738 (21%), Positives = 715/1738 (41%), Gaps = 202/1738 (11%)

Query: 341  ELTLALENELLVTKNSIHQAALASFKAEIRHLL-----------ERVDQVVREKEKLRSD 389
            E  L  E E L  +    Q  L   + ++R L            E+  Q +R +++LR  
Sbjct: 250  ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309

Query: 390  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 449
             ++  + +     E  +     E R E  LR+  EE +E+      +LR+E+E+  ++  
Sbjct: 310  QEEERREQQEERREQQERREQQEERREQQLRREQEERREQ------QLRREQEEERREQQ 363

Query: 450  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509
             +R + E+  E+    E  +R    L  ++  R E + L   ++L   + L  + Q   E
Sbjct: 364  LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ-LRREQQLRREQQLRREQQLRRE 422

Query: 510  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE----LQSELEEYRAQG 565
              L  +             QEE   + ++E ER+ + L+ + +E    L+ E E  R + 
Sbjct: 423  QQLRRE-------------QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQ 469

Query: 566  RVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ-MKEQHHRDICC 624
               +  LK    EE       +E E     +E     +  E E   EQ +K Q   +   
Sbjct: 470  ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529

Query: 625  LRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAA 684
             RL  E ++R  +++           +E + +R E +    E++   LK E         
Sbjct: 530  QRLRSEQQLRREQEE----------RREQLLKREEEKRLEQERREQRLKRE--------- 570

Query: 685  VLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKL------RLQHEMELKARLTQAQASF 738
              +E   +   + EEE++Q ++K E+E+  L+++L      RL+ E   + RL + +   
Sbjct: 571  --QEERRDQLLKREEERRQQRLKREQEE-RLEQRLKREEVERLEQEERREQRLKREEPEE 627

Query: 739  EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQREL-Q 797
            ER ++ L+S    E + + L +E ++  +++L    E+  LE+   R+   E+ ++EL +
Sbjct: 628  ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687

Query: 798  EGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ 857
            E +E+       R  + + Q +S+      +  S  +  EG+ R++ ++ + ++RE + Q
Sbjct: 688  EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747

Query: 858  WEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQ 917
            W+ E+    Q+  E Q       +R+ T      Q  E  E+  ++ L++    R+Q  +
Sbjct: 748  WQEEERAHRQQQEEEQ-------RRDFTWQ---WQAEEKSERG-RQRLSARPPLREQRER 796

Query: 918  DLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQL-ASQRLERLEMEH 976
             L         Q+ L  +   E K   +R+ RERE+ L      EQL   +R ++L+ E 
Sbjct: 797  QLRAEERQQREQRFLPEE---EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE 853

Query: 977  D---QERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1033
            D   ++++   S+    +   +   E   + R         LQ ++++ QQ      +LQ
Sbjct: 854  DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ------LLQ 907

Query: 1034 SGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQ 1093
               + +  EE E        +Q  Q  EE       LQ+  EQ ++E         R ++
Sbjct: 908  EEEEELQREERE---KRRRQEQERQYREEE-----QLQQEEEQLLRE--------EREKR 951

Query: 1094 RLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVR 1153
            R Q+ E        L +   +  G   E+     ++ + ++ E + +       E+ E R
Sbjct: 952  RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011

Query: 1154 DLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCAD 1213
                      ++ E++ EE +   E   +    E  R   +  + ++ Q +EQL+    +
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQYREEEELQQEEEQLLGEERE 1069

Query: 1214 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM---- 1269
              R  E ++    +  + +++ ++L   PE   + +   E   RE + LQ+E   +    
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE--RERQCREEEELQQEEEQLLREE 1127

Query: 1270 -ETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1328
             E R  + LE       EV + +++L + E        LE+ Y E +   +E   L+   
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187

Query: 1329 QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLN-QTLEECVPRVRSVHHVIEEC 1387
            Q K  + +E   +  +    +   +    E   + L+   +  +E   R   V+    E 
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247

Query: 1388 KQENQYLEGNTQLLEKVKAHEIAWLHGTIQ---THQERPRVQ---------NQVILEENT 1435
            +Q  Q LE ++QL ++    ++  L G  Q     QER R Q          Q+  EE  
Sbjct: 1248 EQFRQ-LE-DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305

Query: 1436 TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMM 1495
                   K  + +  + E   EK + QE  RK +E   +L ++        +E+ L+   
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER--------EEQPLRRQE 1357

Query: 1496 HDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT--LNEEDSISNLKLGTLNGSQEE 1553
             D +    E++ + +  ++    L++E  + R E     L EE      +L      Q+ 
Sbjct: 1358 RDRKFREEELRHQEQGRKF----LEEEQRLRRQERERKFLKEEQ-----QLRCQEREQQL 1408

Query: 1554 MWQKTETVKQENAAVQKMVENLKKQISELKIKNQQ-----LDLENTELSQKNSQNQEKLQ 1608
               +    ++E   + +   + K +  E +++ Q+     L+ E     +++ + +E+ Q
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468

Query: 1609 ELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQ 1668
             L +R  + L ++E++     LEE +Q +   ++E +R   +        E +  E + Q
Sbjct: 1469 LLQEREEQQLHRQERD--RKFLEEEQQLR---RQERDRKFREQELRSQEPERKFLEEEQQ 1523

Query: 1669 THIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVD 1728
             H  Q++   L++E +  +Q        D  +K        E+L +E+E   E+  S  +
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE----EEQLRQERE---EQQLSRQE 1576

Query: 1729 KLAKSSLLEHRIATMKQEQKSW--EHQSASLKSQLVASQEKVQNLEDTVQ----NVNLQM 1782
            +  K  L E ++   +QE+K    E Q    + Q    QE+ +   +  Q        Q+
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636

Query: 1783 SRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLD 1842
             R + D +  ++E +  +QE     +QL++   + +  E      G   Q +R   D+  
Sbjct: 1637 HRQERDRKFLEEEPQLRRQE---REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR-- 1691

Query: 1843 HLMNEEQQLLWQENER--LQTMVQNTKAELT---HSREKVRQ-LESNLLPKHQKHLNPSG 1896
                EEQQL  QE ER  LQ   Q  + EL       E++RQ  E   L + +++     
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY----- 1746

Query: 1897 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ 1956
                 E+E+L  +RE  Q ++++   +RK  +   L QE E   L ++   +K  + ++ 
Sbjct: 1747 -RKILEEEQLRPEREEQQLRRQE--RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQL 1803

Query: 1957 LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE 2014
              E +  +         + W+ + LQ            L+ Q Q L+ ER  Q+  EE
Sbjct: 1804 RQEREEQQLRPQQRDGKYRWEEEQLQ------------LEEQEQRLRQERDRQYRAEE 1849



 Score =  196 bits (497), Expect = 3e-49
 Identities = 389/1767 (22%), Positives = 715/1767 (40%), Gaps = 237/1767 (13%)

Query: 325  ILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKE 384
            IL+ LD   +G ++  E  L            I + A A + A        + Q     E
Sbjct: 57   ILELLDLDSNGRVDFNEFLLF-----------IFKVAQACYYA--------LGQATGLDE 97

Query: 385  KLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI 444
            + R+  D  E L      E D      +RR E   R+L+EE  +R    + E  +E  + 
Sbjct: 98   EKRARCDGKESLLQDRRQEED------QRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG 151

Query: 445  LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLEN-----AEKLAEYEN 499
             +Q+ KQ   LEQ  ++ + +E   R R     +E  R E E L++      E+  + E 
Sbjct: 152  EEQSEKQE-RLEQR-DRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209

Query: 500  LTNKLQRNLENVLAEKFGDLDPSSAEFFLQEE-------RLTQMRNEYERQCRVLQDQVD 552
            L  +    L     E+         +   QEE       R T +R E E+    LQ++  
Sbjct: 210  LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK----LQEEEP 265

Query: 553  ELQSELEEYRAQGRVL-RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVI 611
            + Q EL+E   Q R L R  L+    EE +        +     +E        E     
Sbjct: 266  QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325

Query: 612  EQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD 671
            E+ ++Q  R    LR E E++    E+QL       ++ Q+  +++ E       ++   
Sbjct: 326  ERREQQEERREQQLRREQEER---REQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 672  LKNEIAELQGQAAVLKE--AHHEATCRHEEE-KKQLQVKLEEEKTHLQEKLRLQHEMELK 728
            L+ E  +L+ +  + +E     E   R E++ +++ Q++ E++    QE+ R + + E +
Sbjct: 383  LRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441

Query: 729  ARLTQAQASFEREREGLQSSAWT-----EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEE 783
             R  + +   E  R+ L+    T     E + + L ++ E+  +E+   L E+   E++E
Sbjct: 442  RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501

Query: 784  LRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE 843
             R++ L + Q E +E R K + E  R    ++ + +S+ Q   E+ E   Q L+   R+E
Sbjct: 502  RREQQLRREQEERREQRLKRQEEEER----LQQRLRSEQQLRREQEERREQLLK---REE 554

Query: 844  LKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKE 903
             K L++++RE++ + E +++   Q     +E  ++ LKRE+   L    +RE +E+  +E
Sbjct: 555  EKRLEQERREQRLKRE-QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613

Query: 904  HLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQ 963
                  ++R++  ++       SE Q+     Q+       +RE +ER E   +    E+
Sbjct: 614  ERREQRLKREEPEEERRQQLLKSEEQEERRQQQL-------RREQQERREQRLKREEEEE 666

Query: 964  LASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1023
               QRL+R   EH++ER+E        E   +       + + ++ +E    QSK+    
Sbjct: 667  RLEQRLKR---EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723

Query: 1024 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVK 1083
            +        Q G +   E+E +     S LQ  E+            +RAH Q  +E  +
Sbjct: 724  RK-------QEGQRRRQEQEEKRRRRESELQWQEE------------ERAHRQQQEEEQR 764

Query: 1084 -------MATEIS-RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEP-FLQQNRTKQ 1134
                    A E S R +QRL    P        ++   +      +Q E  FL +   K+
Sbjct: 765  RDFTWQWQAEEKSERGRQRLSARPP------LREQRERQLRAEERQQREQRFLPEEEEKE 818

Query: 1135 VEGVTRRH---VLSDLEDDEVRDLGSTGTSSVQRQE--VKIEESEASVEGFSELENSEET 1189
                 RR     L  LE++E           +QR+E   +++E E  ++   E   S+E 
Sbjct: 819  QRRRQRREREKELQFLEEEE----------QLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868

Query: 1190 RTES---WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASP 1246
            R +    W+L+ +  + +  L    A  ++  +++Q L  +   L+++ +   R  E   
Sbjct: 869  RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928

Query: 1247 KYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLS 1306
            +Y+   +    E   L+EE    E R  +  E       ++ + +++L   E        
Sbjct: 929  QYREEEQLQQEEEQLLREE---REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985

Query: 1307 LEKSY-DEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENL-EIEPDGNIL 1364
             EK Y +E +++ EE    +LR + +  + QE          WE       E++ +   L
Sbjct: 986  REKKYREEEELQQEEEQ--LLREEREKRRRQE----------WERQYRKKDELQQEEEQL 1033

Query: 1365 QLNQTLEECVPRVRSVHHVIEECKQENQYLEG------NTQLLEKVKAHEIAWLHGTIQT 1418
               +  +  +      +   EE +QE + L G        Q LE+    E        Q 
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093

Query: 1419 HQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ 1478
             +E P  + +   +E       +++  Q +  +   E EK + QEL R+ +E   +  ++
Sbjct: 1094 LREEPEKRRR---QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150

Query: 1479 KDVLSHGEKEEELKAMMHDLQITCSE----MQQKVELLRYESEKLQQENSILRNEITTLN 1534
            + +L    +EE  K    +L+    E     Q++ +LLR E EK +QE      E   L 
Sbjct: 1151 EQLL----REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206

Query: 1535 EEDSISNLKLGTLNGSQEEMWQ-KTETVKQENAAVQKMVENLKKQISELKIKNQQLDLEN 1593
             +      +        +  W+ + E   ++N    K  EN            Q   LE+
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN-----------EQFRQLED 1255

Query: 1594 TELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSST 1653
            ++L  + SQ     Q+L   L E   ++++E      ++R++  F  +E+LER       
Sbjct: 1256 SQLRDRQSQ-----QDLQHLLGEQQ-ERDREQERRRWQQRDRH-FPEEEQLER------- 1301

Query: 1654 LVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLL 1713
                   E  E K +    Q+E  LL++E E+ ++          +Q+        E+LL
Sbjct: 1302 ------EEQKEAKRRDRKSQEEKQLLREEREEKRR----------RQETDRKFREEEQLL 1345

Query: 1714 KEKEALSEELNSCVDKLAKSSLLEHRIATMK--QEQKSWEHQSASLK----SQLVASQEK 1767
            +E+E          D+  +   L H+    K  +E++    Q    K     Q +  QE+
Sbjct: 1346 QEREEQPLRRQE-RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404

Query: 1768 VQNL----EDTVQNVNLQMSRMKSDLRVTQQEKEALKQE----VMSLHKQLQNAGGKSWA 1819
             Q L    +   +    Q+SR + D +  ++E++  +QE     +   +QL+    + + 
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464

Query: 1820 PEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQ 1879
             E          Q  R   D+    + EEQQL  QE +R     +  + EL     + + 
Sbjct: 1465 EEEQLLQEREEQQLHRQERDR--KFLEEEQQLRRQERDR-----KFREQELRSQEPERKF 1517

Query: 1880 LESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETI 1939
            LE       ++ L+         QE+  L+R+ ++ Q+ +   +RK  +   L QE E  
Sbjct: 1518 LE------EEQQLHRQQRQRKFLQEEQQLRRQ-ERGQQRRQDRDRKFREEEQLRQEREEQ 1570

Query: 1940 HLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP---HAWDLQLLQQQACPMVPREQFLQ 1996
             L  +  + ++ +L+EQ +  Q                    QL Q++       EQ LQ
Sbjct: 1571 QLSRQE-RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQ 1629

Query: 1997 --LQRQLLQAERINQHLQEELENRTSE 2021
               ++QL + ER  + L+EE + R  E
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQE 1656



 Score =  167 bits (423), Expect = 1e-40
 Identities = 345/1627 (21%), Positives = 662/1627 (40%), Gaps = 197/1627 (12%)

Query: 375  RVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALK 434
            R +Q  R +++LR + ++ E+ +  +  E ++     + R E  LR+  +  +E+    +
Sbjct: 340  RREQEERREQQLRREQEE-ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398

Query: 435  NELRKE----REQILQQAGKQRLE--LEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +LR+E    REQ L++  + R E  L +E E+ + E+ + ++R    LK       + L
Sbjct: 399  QQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWL 458

Query: 489  ENAEKLAEYENLTNK--LQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 546
            +  E+   +E    K  L+R+ E    E++  L+        QE R  Q+R E E +   
Sbjct: 459  KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE-QQERREQQLRREQEER--- 514

Query: 547  LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 606
               +   L+ + EE R Q R+          EE        E E  L  E         +
Sbjct: 515  ---REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ 571

Query: 607  AELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLE 666
             E   + +K +  R    L+ E E+++   E++L    V   + +E  +QR + E    E
Sbjct: 572  EERRDQLLKREEERRQQRLKREQEERL---EQRLKREEVERLEQEERREQRLKREEPEEE 628

Query: 667  KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME 726
            ++   LK+E  E         E   +   R ++E+++ ++K EEE+  L+++L+ +HE E
Sbjct: 629  RRQQLLKSEEQE---------ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679

Query: 727  -----------------LKARLTQAQASFEREREGLQSSAWT--------------EEKV 755
                             +K+R+ + Q   E E +  QS  ++              EEK 
Sbjct: 680  RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR 739

Query: 756  RGLTQEL-----EQFHQEQ-------------------------LTSLVEKHTLEKEELR 785
            R    EL     E+ H++Q                         L++        + +LR
Sbjct: 740  RRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLR 799

Query: 786  -KELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVT--ERCESALQSLEGRYR- 841
             +E  ++ QR L E  EK +    RR  + E QF  + +++   ER +   +  +G    
Sbjct: 800  AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859

Query: 842  QELKDLQEQQREEKSQWEFEKD-ELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900
            QE +  QEQ+R++K +W+ E++ +  +    A+  L+E L++E+    +L +E E L++ 
Sbjct: 860  QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ---LLQEEEEELQRE 916

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960
             +E       ERQ         R   + QQ    +Q+L      +RE R R+E   Q   
Sbjct: 917  EREKRRRQEQERQY--------REEEQLQQE--EEQLLR----EEREKRRRQERERQYRK 962

Query: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST--EISRLQSK 1018
             ++L  +  + L  E ++ R++   K    E   +   E   RE  E     E  R   K
Sbjct: 963  DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022

Query: 1019 IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAV 1078
              E+QQ    L   +   + + E E +      L Q+ EQLL E  +     Q    Q  
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR-QELERQYR 1081

Query: 1079 KENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGV 1138
            KE      E   L++  +K         C +E   +      ++ E  L++ R K+    
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQ------QEEEQLLREEREKRRRQE 1135

Query: 1139 TRRHVLSDLE-DDEVRDLGSTGTSSVQRQEVKI---EESEASVEGFSELENSEETRTESW 1194
              R    + E   E   L        +RQE++    EE E   E    L   +E R +  
Sbjct: 1136 LERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ-- 1193

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERI---PEASPKYKLL 1251
            E + Q  + +E          R  +++ DL +     K+      ++      + +++ L
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253

Query: 1252 YEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRL--QDELKKMEEVTETFLSLEK 1309
             +   R+    Q+   ++  + +   E  +    +  R   ++E  + EE  E      K
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313

Query: 1310 SYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQT 1369
            S +E ++  EE      R Q    K +E           E  L+  E +P     +  + 
Sbjct: 1314 SQEEKQLLREEREEK-RRRQETDRKFREE----------EQLLQEREEQPLRRQERDRKF 1362

Query: 1370 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRV---- 1425
             EE +         +EE +Q  +  E   + L++ +  ++       Q  Q+R R     
Sbjct: 1363 REEELRHQEQGRKFLEE-EQRLRRQERERKFLKEEQ--QLRCQEREQQLRQDRDRKFREE 1419

Query: 1426 QNQVILEENTTLLGFQDKHFQHQATIAE-LELEKTKLQELTRKLKERVTILVKQKDVLSH 1484
            + Q+  +E       +++  + Q    + LE E+   QE  RK +E   +L ++++   H
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479

Query: 1485 GEKEEELKAMMHDLQITCSEMQQKV---ELLRYESEK--LQQENSILRNEITT--LNEED 1537
              +E + K +  + Q+   E  +K    EL   E E+  L++E  + R +     L EE 
Sbjct: 1480 -RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ 1538

Query: 1538 SISNLKLGTLNGS-QEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTEL 1596
             +   + G      ++  +++ E ++QE    Q     L +Q  + K + ++  +   E 
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ-----LSRQERDRKFRLEEQKVRRQEQ 1593

Query: 1597 SQKNSQNQEKL--QELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTL 1654
             +K  +++++L  QE  Q+L +   +K +E     L+ERE+++ + ++E +R  ++    
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFRED-EQLLQEREEQQLH-RQERDRKFLEEEPQ 1651

Query: 1655 VSSLEAELSEVKIQTHIVQQENHLLKD-ELEKMKQLHRCPDLSDFQQKISSVLSYNEKLL 1713
            +   E E      +    ++E  LL++ E +++++  R     + +Q++       + L 
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ 1711

Query: 1714 KEKEALSEELNSCV--DKLAKSSLLEHRIATMKQEQKSWEHQSA--SLKSQLVASQEKVQ 1769
            +E++   +EL      ++  +    + ++   ++ +K  E +      + Q +  QE+ +
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDR 1771

Query: 1770 NLEDTVQNVNLQMSRMKSDLRVTQ-----QEKEALKQEVMSLHKQLQNAGGK-SWAPEIA 1823
               +  Q   L+  R +  LR  +     +E+E L+QE      + Q   GK  W  E  
Sbjct: 1772 KFREEEQ---LRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL 1828

Query: 1824 THPSGLHNQQKRLSWDKLDHLMNEEQ-----------QLLWQENERLQTMVQNTKAELTH 1872
                 L  Q++RL  ++      EEQ           Q LWQE E+ +   +  K    H
Sbjct: 1829 Q----LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEH 1884

Query: 1873 SREKVRQ 1879
             R + ++
Sbjct: 1885 IRRQQKE 1891



 Score =  112 bits (279), Expect = 5e-24
 Identities = 152/666 (22%), Positives = 284/666 (42%), Gaps = 66/666 (9%)

Query: 370  RHLLERVDQVVREKEKLRSDLD-KAEKLKSLMASEVDDHHAAIERRNEYNLRK-LDEEYK 427
            RH  E  +Q+ RE++K     D K+++ K L+  E ++     E   ++   + L +E +
Sbjct: 1291 RHFPEE-EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349

Query: 428  ERIAALKNELRKEREQIL--QQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN 485
            E+    +   RK RE+ L  Q+ G++ LE EQ + + + E  ++++   L  +E    E 
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER---EQ 1406

Query: 486  ELLENAE-KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 544
            +L ++ + K  E E   ++ +R+ +    E+         +F  +E++L Q R+   R+ 
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466

Query: 545  RVLQDQVDELQSELEE----YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
              L  + +E Q   +E    +  + + LR   ++    E E  S   EPE     EE   
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ--EPERKFLEEE--- 1521

Query: 601  LNMSIEAELVIEQM-KEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 659
                       +Q+ ++Q  R      L+ E ++R  E+         +K +E  + R E
Sbjct: 1522 -----------QQLHRQQRQRKF----LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566

Query: 660  NETHTLEKQISDLKNEIAE--LQGQAAVLKEAHHEATCRHEEEKKQLQV----KLEEEKT 713
             E   L +Q  D K  + E  ++ Q    K    E   R +E ++QL+     K  E++ 
Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626

Query: 714  HLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTS 772
             LQE+   Q H  E   +  + +    R+    Q     + K R   Q L++  ++QL  
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR 1686

Query: 773  LVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESA 832
                    +EE +    E+ ++ LQE ++    E  R+  + E   Q   Q+   R E  
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY 1746

Query: 833  LQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQ 892
             + LE    +  ++ Q+ +R+E+ +   E+++L QE  E Q+L  +   R+      L Q
Sbjct: 1747 RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE-REEQQLRSQESDRKFREEEQLRQ 1805

Query: 893  EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRERE 952
            ER                E QQL     D +   E +Q  L +Q   L+    R+ R  E
Sbjct: 1806 ER----------------EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEE 1849

Query: 953  EVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEI 1012
            +      A+++ + +  + L  E +Q+R++   + L  E+I +   +  + +R     EI
Sbjct: 1850 QF-----ATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR---QQKEEQRHRQVGEI 1901

Query: 1013 SRLQSK 1018
               + K
Sbjct: 1902 KSQEGK 1907



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 96/448 (21%), Positives = 179/448 (39%), Gaps = 97/448 (21%)

Query: 1599 KNSQNQEKLQELNQRLTEMLC-QKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSS 1657
            K S  Q++ QE +QR  E    Q E+EPG    ++R++++  L E  E+ + Q       
Sbjct: 106  KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165

Query: 1658 LEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCP--DLSDFQQKISSVLSYNEKLLKE 1715
             +    E+  Q    Q+      +E    +QL  C   +  +F          +E+ L+ 
Sbjct: 166  RQRRDEELWRQRQEWQEREERRAEE----EQLQSCKGHETEEFP---------DEEQLRR 212

Query: 1716 KEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTV 1775
            +E L        +K  +    + R+   ++E+K W  +   L+ +    +EK+Q  E   
Sbjct: 213  RELLELRRKGREEKQQQRRERQDRVF-QEEEEKEWRKRETVLRKE----EEKLQEEEPQR 267

Query: 1776 QNVNLQMSRMKSDLRVTQQEKEALKQ-EVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1834
            Q             R  Q+E+E L++ E   L ++ Q                    QQ+
Sbjct: 268  Q-------------RELQEEEEQLRKLERQELRRERQEE----------------EQQQQ 298

Query: 1835 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNP 1894
            RL          E+Q    QE ER +   Q  + E    RE+  +     L + Q+    
Sbjct: 299  RLR--------REQQLRRKQEEERREQ--QEERREQQERREQQEERREQQLRREQE---- 344

Query: 1895 SGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLD 1954
                   E+ +  L+RE ++ ++EQ            L +E E    E +  +++Q++ +
Sbjct: 345  -------ERREQQLRREQEEERREQQ-----------LRREQEEERREQQLRREQQLRRE 386

Query: 1955 EQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE 2014
            +QL   Q LR            + QL ++Q    + REQ L+ ++QL + +++ +  +EE
Sbjct: 387  QQLRREQQLRR-----------EQQLRREQ---QLRREQQLRREQQLRREQQLRREQEEE 432

Query: 2015 LENRTSETNTPQALLPEQRAVHADSYRR 2042
               +  E    +  L  ++    D  +R
Sbjct: 433  RHEQKHEQERREQRLKREQEERRDWLKR 460


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  202 bits (514), Expect = 3e-51
 Identities = 403/1935 (20%), Positives = 822/1935 (42%), Gaps = 350/1935 (18%)

Query: 262  RQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIEN 321
            RQ+   L M+  + +  R+      T     R      +      +E+ L T Q+     
Sbjct: 371  RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK----- 425

Query: 322  SQEILKALDFSLDGNINLTELT-----LALENELLVTKNSIHQAALASFKAEIRHLLERV 376
            ++E  + L   +D  I   E T     ++L+ EL   K  +      S + +I  L    
Sbjct: 426  TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL---- 481

Query: 377  DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 436
             Q + EKE  R + +  +KL++      +    A+E+     L+   E+ ++   AL+ E
Sbjct: 482  -QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE-E 539

Query: 437  LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLEN--AEKL 494
            L  +++ IL ++  +  +L+QE E  +T    +   L  SL+EN     +L  +  AEK 
Sbjct: 540  LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599

Query: 495  AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE- 553
               + +T  ++++   + + K         +  L  E+L  ++ +Y+ +   L+++ ++ 
Sbjct: 600  KHNKEITVMVEKHKTELESLK-------HQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652

Query: 554  -----------LQSELEEYRAQGRVLRLPLKNSPSEEVEAN-SGGIEPEHGLGSEECNPL 601
                        Q+ +EE   +  + +L +K +  E + +  S  ++  H L  EE + L
Sbjct: 653  KETLLKDKEIIFQAHIEEMN-EKTLEKLDVKQTELESLSSELSEVLKARHKL-EEELSVL 710

Query: 602  -----NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KAQENMK 655
                  M  E E  +++ K  H + +  +  E E  ++  EK L + +   +   +E  K
Sbjct: 711  KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770

Query: 656  QRHENETHTLEKQISDLKNEIAELQGQAAVL------KEAHHEATCRHEEEKKQLQVKLE 709
               E++ H +E   +D+K    ELQ  +A L      + A HE T  +EE+  QLQ KL 
Sbjct: 771  HLKEHQAH-VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829

Query: 710  EEKTH--LQEKLRLQHEMELKARLTQAQASFEREREGLQ----SSAWTEEKVRGLTQ--- 760
            + +T   L  K   + E + K   T+  A   + ++ +Q     ++  E+KV+ LTQ   
Sbjct: 830  DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYE 889

Query: 761  -ELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKM---ETECNRRTSQIEA 816
             +LE  ++EQ     ++  +EKE +  ++ E  ++E++   +K+   E   +    + E 
Sbjct: 890  SKLEDGNKEQ--EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 947

Query: 817  QFQSD---CQKVTERCESALQSL-------EGRYRQELKDLQEQQREEKSQWEFEKDELT 866
            +F++     +KV ++ +   ++L       E + ++EL++   +  +++ Q+  +  E+ 
Sbjct: 948  KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007

Query: 867  QE----CAEAQELLKETLKREKTTSLVLTQEREMLE--KTYKEHLNSMVVERQQL--LQD 918
            Q      ++A   L ET ++E+  SL     RE+ +    +++ LN    E Q++  +Q 
Sbjct: 1008 QANSAGISDAVSRL-ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL 1066

Query: 919  LEDLRNVSETQQSLL---------SDQILELKSSHKRE---LREREEVLCQAGA------ 960
             E  + V+E +Q +L         + +I  LK    ++   L E +E L Q  A      
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126

Query: 961  -SEQLASQRLERLEMEHDQERQE---MMSKLLAMENIHKATCETADRERAEMSTEISRLQ 1016
              E      LE+LE++ ++  +E   +  +L+ ++ +       A+ ++ ++S   S+L+
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML-------AEEDKRKVSELTSKLK 1179

Query: 1017 SKIKEMQQATSPLSMLQSGCQ--VIGEEEVEGDGALSL---LQQGEQLLEENGDVLLSLQ 1071
            +  +E Q   S         +   +  +++  + A+ L    ++ E LLE   + L+++ 
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239

Query: 1072 RAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNR 1131
             +   A+       + IS  Q R  K++  L++ +C              Q     ++  
Sbjct: 1240 SSKTNAI------LSRISHCQHRTTKVKEALLIKTCT-------VSELEAQLRQLTEEQN 1286

Query: 1132 TKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELEN------ 1185
            T  +      H L + ++++++ + +   S V  +E   +E     +  SE E+      
Sbjct: 1287 TLNISFQQATHQLEE-KENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLK 1345

Query: 1186 ---SEE------TRTESWELKNQISQLQEQLMMLCADCDRA---SEKK------------ 1221
               SE        + E  E K +IS L +QL  L      +   SEK+            
Sbjct: 1346 KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE 1405

Query: 1222 ---------QDLLFDVSVL-KKKLKMLERIPEASPKY----KLLYEDVSRENDCLQEELR 1267
                     QDL F V  L K+K+  LE++ + S K+    K      ++  + ++E   
Sbjct: 1406 EKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465

Query: 1268 MMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNV-LVL 1326
             +E +  EA E ++++      L  + K+ +      L  E   D+ K+E +E N+   L
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFD-----CLKGEMEDDKSKMEKKESNLETEL 1520

Query: 1327 RLQ-GKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQ-LNQTLE----ECVPRVRSV 1380
            + Q  +I +L++ + Q+            +EIE    +L+  NQ  +    E V +++  
Sbjct: 1521 KSQTARIMELEDHITQK-----------TIEIESLNEVLKNYNQQKDIEHKELVQKLQHF 1569

Query: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440
              + EE  ++N+  E   ++L     +++  +   ++T ++     N  +  +   L   
Sbjct: 1570 QELGEE--KDNRVKEAEEKIL--TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKAL 1625

Query: 1441 QDKHFQHQATIAELELEK-TKLQELTRKLKERVTILVKQKDVLSHGEKEEE-----LKAM 1494
            +D+          LE E   KL EL RK ++++  + KQ  +LS  E++EE      ++ 
Sbjct: 1626 EDR----------LESESAAKLAELKRKAEQKIAAIKKQ--LLSQMEEKEEQYKKGTESH 1673

Query: 1495 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGT------LN 1548
            + +L     E +++V +L    EKL+   S+  ++  TL    S  N+   T        
Sbjct: 1674 LSELNTKLQEREREVHIL---EEKLK---SVESSQSETLIVPRSAKNVAAYTEQEEADSQ 1727

Query: 1549 GSQEEMWQKTETVKQENAA-----VQKMVENLKKQIS---ELKIKNQQ--LDLENTELSQ 1598
            G  ++ +++  +V Q N       +Q++ +  ++ +S   E++ + Q+  + LE+ E  Q
Sbjct: 1728 GCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQ 1787

Query: 1599 KNSQN-----QEKLQELNQRLTEMLCQK-EKEPGNSALEEREQEKFNLKEELERCKVQSS 1652
               Q+     QE+L+E N++ + ++ Q  EKE G + +    Q K NL+           
Sbjct: 1788 HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI----QAKQNLE----------- 1832

Query: 1653 TLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1712
             +   ++  L E ++   I++Q          K+K+L  C                   L
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQ----------KIKELDSC-------------------L 1863

Query: 1713 LKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLE 1772
            +++KE    E+     K  K   L+      K  +   E+     KS LV  Q K+    
Sbjct: 1864 VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLV--QPKL---- 1917

Query: 1773 DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQ 1832
              + N+  Q + ++  L   ++EK+ L +E++ L K L+    +        H   L   
Sbjct: 1918 --LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE--------HQQELEIL 1967

Query: 1833 QKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE-----------KVRQLE 1881
            +K    ++ + +  E++ L  + N  L+ +++    +L    +           K +++E
Sbjct: 1968 KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027

Query: 1882 SNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKV-SQMNSLEQELETIH 1940
            + LL  HQ+  N    +    ++   LKR   ++++       ++ +++  L+ +LE + 
Sbjct: 2028 AELLESHQEETNQ--LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ 2085

Query: 1941 LENEGLKKKQVKLDEQ---------LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1991
                  KK Q KL+++         +ME+Q   +  T   S    D +L +Q+      R
Sbjct: 2086 ------KKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS----DSKLKEQEF-----R 2130

Query: 1992 EQFLQLQRQLLQAER 2006
            EQ   L+ +L + E+
Sbjct: 2131 EQIHNLEDRLKKYEK 2145



 Score =  192 bits (489), Expect = 2e-48
 Identities = 375/1847 (20%), Positives = 770/1847 (41%), Gaps = 327/1847 (17%)

Query: 345  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 404
            +L  E L+ +    + +L+S++ +   L+     + REK+KL+  L +++       +E+
Sbjct: 133  SLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL 192

Query: 405  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEK 461
             +     ++  ++   + D   EE  + I+ L+ ++   ++++  + G   +++ + + +
Sbjct: 193  REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL--RNGPMNVDVLKPLPQ 250

Query: 462  AKTEENYIRDRLALSLKENSRLENE-LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 520
             + +          + +EN   + E ++E+   +   E L  +++R  EN+L      + 
Sbjct: 251  LEPQAE------VFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQ-ENLLKRCKETIQ 303

Query: 521  PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR----AQGRVLRLPLKNSP 576
                     +E+ T + +E E     LQ+Q+DE   ELE+ +    A+   L   L+++ 
Sbjct: 304  S-------HKEQCTLLTSEKE----ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK 352

Query: 577  S--EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL-EDKV 633
            +  E++E + G                       +VI + K Q H       LE+ E+++
Sbjct: 353  NLIEQLEQDKG-----------------------MVIAETKRQMHET-----LEMKEEEI 384

Query: 634  RHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEA 693
                 ++ +     ++ +E  ++        LEK +S            A   +EA  + 
Sbjct: 385  AQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST-----------AQKTEEARRKL 433

Query: 694  TCRHEEEKKQLQVKLEEEKTHLQE----------------------KLRLQHEMELKARL 731
                +E+ K ++   EEE+  LQ+                      KL+  HE EL  + 
Sbjct: 434  KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE 493

Query: 732  TQAQASFE-REREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE 790
             +     + RERE  +      EK +    ++ Q  ++Q +  +E+  L+K+ +  E  E
Sbjct: 494  QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTE-SE 552

Query: 791  KHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQEL------ 844
               R+LQ+  E   T      S +E   Q + +  ++     L++ + ++ +E+      
Sbjct: 553  NKLRDLQQEAETYRTRILELESSLEKSLQEN-KNQSKDLAVHLEAEKNKHNKEITVMVEK 611

Query: 845  --KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 902
               +L+  + ++ + W  +   L Q+     E L+E  ++EK T   L +++E++ + + 
Sbjct: 612  HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKET---LLKDKEIIFQAHI 668

Query: 903  EHLNSMVVERQQLLQ-DLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGAS 961
            E +N   +E+  + Q +LE L   SE  + L +   LE + S  ++  ++ +   +A   
Sbjct: 669  EEMNEKTLEKLDVKQTELESLS--SELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD 726

Query: 962  EQL--ASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKI 1019
            EQ     Q+++ +  EH+   Q     L    N  +   +  D+   E    +  L++ I
Sbjct: 727  EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADI 786

Query: 1020 K----EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLE-ENGDVLLSLQRAH 1074
            K    E+QQA++ L + QS      E+    +  L+ LQQ  +LL+ E   +LL+ Q A 
Sbjct: 787  KRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ--KLLDLETERILLTKQVAE 844

Query: 1075 EQAVKENVKMATEIS----RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1130
             +A K++V   TE+     ++Q  +Q+LE          +  T+ + +  E      +Q 
Sbjct: 845  VEAQKKDV--CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK--EQE 900

Query: 1131 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1190
            +TKQ+  V + +++  + + + +++           E+  ++  A  +    L    ET+
Sbjct: 901  QTKQIL-VEKENMILQMREGQKKEI-----------EILTQKLSAKEDSIHILNEEYETK 948

Query: 1191 TESWE-----LKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE-RIPEA 1244
             ++ E     +K +  ++QE L             K+ LL   + LKK+L+     + + 
Sbjct: 949  FKNQEKKMEKVKQKAKEMQETL-------------KKKLLDQEAKLKKELENTALELSQK 995

Query: 1245 SPKYKLLYEDVSRENDC-LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTET 1303
              ++     ++++ N   + + +  +ET   E +E+      EV R         E+ + 
Sbjct: 996  EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIES----LTEVHR--------RELNDV 1043

Query: 1304 FLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNI 1363
                EK  ++   E +E++ + L+     EK QE    +    L+    E +  E     
Sbjct: 1044 ISIWEKKLNQQAEELQEIHEIQLQ-----EKEQEVAELKQKILLFGCEKEEMNKE----- 1093

Query: 1364 LQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERP 1423
              +    EE V +  +++ + E+ KQ++ ++    Q   K+KA            H E+ 
Sbjct: 1094 --ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKA------------HLEKL 1139

Query: 1424 RVQNQVILEENTTLLGFQDKHFQHQATIAELEL----EKTKLQELTRKLK---ERVTILV 1476
             V     L+ENT L          Q  + EL++    +K K+ ELT KLK   E    L 
Sbjct: 1140 EVDLNKSLKENTFL----------QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLK 1189

Query: 1477 K--QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVE-LLRYESEKLQQENSILRNEI--- 1530
               +K   S  +K  E K +  +L I      +K E LL  ++ +L   +S   N I   
Sbjct: 1190 SSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSR 1249

Query: 1531 -------TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELK 1583
                   TT  +E  +  +K  T++  + ++ Q TE     N + Q+    L+++  E +
Sbjct: 1250 ISHCQHRTTKVKEALL--IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEK--ENQ 1305

Query: 1584 IKNQQLDLEN----TELSQKNSQNQEKL------------QELNQRLTEMLCQKEKEPGN 1627
            IK+ + D+E+     E  QK   NQ++             +EL++ +  +   KE+    
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEE---- 1361

Query: 1628 SALEEREQEKFNLKEELERCKVQ---------SSTLVSSLEAELSEVKIQTHIVQQENHL 1678
              L+E++ E  +L ++L    VQ             +SSL  +  E K +     Q+   
Sbjct: 1362 --LKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSF 1419

Query: 1679 LKDEL--EKMKQLHRCPD----LSDFQQKISSVLSYNEKLLKE---------KEAL--SE 1721
              D L  EK+  L +  D     S++++K  S  + ++  +KE         KEA    E
Sbjct: 1420 KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDE 1479

Query: 1722 ELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL 1780
            ++N   ++L  ++   +     M+ ++   E + ++L+++L +   ++  LED +    +
Sbjct: 1480 QINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTI 1539

Query: 1781 QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDK 1840
            ++  +   L+   Q+K+   +E++   +  Q  G                        +K
Sbjct: 1540 EIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE-----------------------EK 1576

Query: 1841 LDHLMNEEQQLLWQENE--RLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT- 1897
             + +   E+++L  EN+   ++  ++  K EL H    V+  E  L     +  + S   
Sbjct: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAK 1636

Query: 1898 ----MNPTEQEKLSLKRECDQFQKEQSPANRK-----VSQMNSLEQELE-TIHLENEGLK 1947
                    EQ+  ++K++     +E+    +K     +S++N+  QE E  +H+  E LK
Sbjct: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK 1696

Query: 1948 KKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQ-LQRQLLQAER 2006
              +    E L+  +  ++ A  +    A        Q C     E+ +  LQR L + E+
Sbjct: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEA------DSQGCVQKTYEEKISVLQRNLTEKEK 1750

Query: 2007 INQHLQEELENRTSETNTPQALLPEQ--RAVHADSYRR-----IGHL 2046
            + Q + +E E   S     +    E+  +  HA++ +      IGHL
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHL 1797



 Score =  156 bits (394), Expect = 2e-37
 Identities = 336/1654 (20%), Positives = 679/1654 (41%), Gaps = 298/1654 (18%)

Query: 600  PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 659
            P +M  EAE ++      +   +      +E  +  Y  +  E V + +  Q   K+   
Sbjct: 117  PSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 176

Query: 660  NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKL 719
              + + +K +  +     ELQ      K    E     EE+ + + V L+ + + L+++L
Sbjct: 177  ILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISV-LQTQVSLLKQRL 235

Query: 720  R--------------LQHEMELKARLTQAQASFE---------REREGLQSSAWTEEKVR 756
            R              L+ + E+  +    ++  E         +  E LQ     +E + 
Sbjct: 236  RNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLL 295

Query: 757  GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE-------KMETECNR 809
               +E  Q H+EQ T L    T EKE L+++L E+ Q EL++ ++       K+ T+   
Sbjct: 296  KRCKETIQSHKEQCTLL----TSEKEALQEQLDERLQ-ELEKIKDLHMAEKTKLITQLRD 350

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLE------GRYRQELKDLQEQQREEKSQWEFEKD 863
              + IE   Q     + E      ++LE       + R  +K +  Q  E + Q E  + 
Sbjct: 351  AKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER 410

Query: 864  ELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLR 923
               +E  +A    ++T +  +     + ++ + +EKT +E   S+  E  ++ Q++ D+ 
Sbjct: 411  AAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVM 470

Query: 924  NVSETQQSLLSDQILELKSSHKREL-------------RERE--------------EVLC 956
              S        +QI +L+  H++EL             RERE              E L 
Sbjct: 471  KKSS------EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLK 524

Query: 957  QAGASEQLASQRLERLEMEH--------------DQERQEMMSKLLAME----------- 991
             +   EQ  S  LE LE++                QE +   +++L +E           
Sbjct: 525  ISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENK 584

Query: 992  NIHKATCETADRERAEMSTEISRLQSK-------IKEMQQA--TSPLSMLQSGCQVIGEE 1042
            N  K      + E+ + + EI+ +  K       +K  Q A  T  L +L+   Q   E+
Sbjct: 585  NQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEK 644

Query: 1043 EVEGDGALSLLQQGEQLLEENGDVLLS-LQRAHEQAVK-------ENVKMATEISRLQQR 1094
              E        Q+ E LL++   +  + ++  +E+ ++       E   +++E+S + + 
Sbjct: 645  LRE-----KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699

Query: 1095 LQKLEPGL-VMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLS-----DLE 1148
              KLE  L V+    D+   E      EQ     + +  +QV+ + + H +S        
Sbjct: 700  RHKLEEELSVLKDQTDKMKQELEAKMDEQ-----KNHHQQQVDSIIKEHEVSIQRTEKAL 754

Query: 1149 DDEVRDLG-----------------STGTSSVQRQEVKIEESEASVEGFSELENSEETRT 1191
             D++  L                      + ++R E +++++ A ++ F   +++   +T
Sbjct: 755  KDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT 814

Query: 1192 ESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLL 1251
            +++E   Q++QLQ++L+ L  + +R    KQ  + +V   KK   +   +     + + L
Sbjct: 815  KAYE--EQLAQLQQKLLDL--ETERILLTKQ--VAEVEAQKK--DVCTELDAHKIQVQDL 866

Query: 1252 YEDVSRENDCLQEELRMMETRYDEALEN-------NKELTAE----VFRLQDELKKMEEV 1300
             + + ++N  ++++++ +   Y+  LE+        K++  E    + ++++  KK  E+
Sbjct: 867  MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926

Query: 1301 TETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPD 1360
                LS ++  D + I NEE        + K+EK+++   +       + +L+   ++ +
Sbjct: 927  LTQKLSAKE--DSIHILNEEYETKFKNQEKKMEKVKQKAKE------MQETLKKKLLDQE 978

Query: 1361 GNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE--IAWLHGTIQT 1418
                +L + LE         +  +E  ++E Q+   N ++LE  +A+   I+     ++T
Sbjct: 979  A---KLKKELE---------NTALELSQKEKQF---NAKMLEMAQANSAGISDAVSRLET 1023

Query: 1419 HQ-ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVK 1477
            +Q E+     +V   E   ++   +K    QA   + E+ + +LQE     KE+    +K
Sbjct: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ-EIHEIQLQE-----KEQEVAELK 1077

Query: 1478 QKDVLSHGEKEEE------LKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1531
            QK +L   EKEE       LK        T +E+Q++++        L Q+ + L+  + 
Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE 1137

Query: 1532 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1591
             L E D   +LK  T    QE++ +     +++   V ++   LK    E +      + 
Sbjct: 1138 KL-EVDLNKSLKENTF--LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194

Query: 1592 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLK--------EE 1643
             N  L  K+ + ++  +EL  +L ++ C+K +    + LE +  E  N+           
Sbjct: 1195 SNKSLEDKSLEFKKLSEELAIQL-DICCKKTE----ALLEAKTNELINISSSKTNAILSR 1249

Query: 1644 LERC-----KVQSSTL-----VSSLEAELSEVKIQTHIV----QQENHLLKDELEKMKQL 1689
            +  C     KV+ + L     VS LEA+L ++  + + +    QQ  H L+++  ++K +
Sbjct: 1250 ISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSM 1309

Query: 1690 HRCPDLSDFQQKISSVLSYNEKLLKE---KEALSEELNSCVDKLAKS-SLLEHRIATMKQ 1745
                     +  I S+++  E L KE   ++  + E  SC+ +L K  S   + +  MK+
Sbjct: 1310 ---------KADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360

Query: 1746 EQKSWEHQSASLKSQLVASQEKVQN------LEDTVQNVNLQMSRMKSDLRVTQQE---- 1795
            E K  + + +SL  QL     ++QN       E  + ++  Q    K +L    Q+    
Sbjct: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK 1420

Query: 1796 KEALKQEVMSLHKQLQNAGGK--SWAPEIATHPSGLHNQQKRLS-----WDKLDHLMNEE 1848
             + L +E +S  +Q+ +   K   W  +  +  +   N  K L        K  +  +E+
Sbjct: 1421 VDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ 1480

Query: 1849 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL----------LPKHQKHLNPSG-- 1896
              LL +E ++        K E+   + K+ + ESNL          + + + H+      
Sbjct: 1481 INLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIE 1540

Query: 1897 -------TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949
                     N  +Q+ +  K    + Q  Q     K +++   E+++ T  LEN+    K
Sbjct: 1541 IESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT--LENQVYSMK 1598

Query: 1950 QVKLDEQLMEMQHLR-STATPSPSPHAWDLQLLQQQACPMV-----PREQFLQLQRQLL- 2002
              +L+ +  E++H+  S  +      A + +L  + A  +        ++   +++QLL 
Sbjct: 1599 -AELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657

Query: 2003 QAERINQHLQEELENRTSETNTPQALLPEQRAVH 2036
            Q E   +  ++  E+  SE NT   L   +R VH
Sbjct: 1658 QMEEKEEQYKKGTESHLSELNT--KLQEREREVH 1689



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 80/334 (23%), Positives = 142/334 (42%), Gaps = 61/334 (18%)

Query: 317  EGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERV 376
            E + +  E L+AL   +DG    TEL L    E     + +    L++ +A+   L  ++
Sbjct: 1875 EELTSKYEKLQALQ-QMDGRNKPTEL-LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKL 1932

Query: 377  DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 436
                REK+KL  ++ + +K                      +LR L +E+++ +  LK E
Sbjct: 1933 AGAEREKQKLGKEIVRLQK----------------------DLRMLRKEHQQELEILKKE 1970

Query: 437  LRKEREQILQQAG-----KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENA 491
              +ERE+ ++Q       K    L+Q + +  T+       L +++KE      E+   A
Sbjct: 1971 YDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEV--EA 2028

Query: 492  EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQV 551
            E L  ++  TN+L + +    AEK  DL  ++  +   EE L     E   + R LQ Q+
Sbjct: 2029 ELLESHQEETNQLLKKI----AEKDDDLKRTAKRY---EEILDAREEEMTAKVRDLQTQL 2081

Query: 552  DELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVI 611
            +ELQ + ++   Q             EE   N      E  L ++      +  +++L  
Sbjct: 2082 EELQKKYQQKLEQ-------------EENPGNDNVTIME--LQTQLAQKTTLISDSKLKE 2126

Query: 612  EQMKEQHHRDICCLRLELEDKVRHYEKQLDETVV 645
            ++ +EQ H         LED+++ YEK +  T V
Sbjct: 2127 QEFREQIHN--------LEDRLKKYEKNVYATTV 2152


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  201 bits (512), Expect = 5e-51
 Identities = 380/1808 (21%), Positives = 742/1808 (41%), Gaps = 250/1808 (13%)

Query: 315  QEEGIENSQEILKALDFSLD-----GNINLTELTLALENELLVTKNSIHQAALASFKAEI 369
            ++E +E   E+   L  + D     G I+  EL    E +LL  +N   +  L +     
Sbjct: 945  KKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQH--EFDLLKKENEQRKRKLQAALINR 1002

Query: 370  RHLLERVDQVVREKEKLRSDLDK---------------------AEKLKSLMASEVDDHH 408
            + LL+RV ++  E   L+ +  K                     +EK  +    E++ + 
Sbjct: 1003 KELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYL 1062

Query: 409  AAIERRNEYNLRKLDEEYKERIAALK--NELRKEREQILQQAGKQRLELEQEIEK----- 461
                   E  L+ + ++ +E++AA +    L K+  Q LQ    Q   L+ EI +     
Sbjct: 1063 KQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAII 1122

Query: 462  -----AKTEEN------YIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLEN 510
                 + T+ +       +++ + +S       E+   E  EK+   E    +LQ+ L+ 
Sbjct: 1123 QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQE 1182

Query: 511  VLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRL 570
             L  +   L  +  +     E L Q +++Y R    LQ+Q DE   E E    Q R L++
Sbjct: 1183 ALTSRKAILKKAQEKERHLREELKQQKDDYNR----LQEQFDEQSKENENIGDQLRQLQI 1238

Query: 571  PLKNS-----PS---EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDI 622
             ++ S     PS   +E  +++ G+E E    + E +     +E+ L  +     H  D 
Sbjct: 1239 QVRESIDGKLPSTDQQESCSSTPGLE-EPLFKATEQHHTQPVLESNLCPDW--PSHSEDA 1295

Query: 623  CCLR-----LELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIA 677
              L+      +++ +++  E +  E  +        + ++ E E   L++QI+    EI 
Sbjct: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSE-EVFQLQEQINKQGLEIE 1354

Query: 678  ELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQAS 737
                    LK   HEA    E   + LQ KLE  +  +     L+H  EL+ +L + Q  
Sbjct: 1355 S-------LKTVSHEA----EVHAESLQQKLESSQLQI---AGLEHLRELQPKLDELQKL 1400

Query: 738  FEREREGLQ-SSAWTEEKVRGLTQ-ELEQFHQE--------QLTSLVEKHTLEKEELRKE 787
              ++ E +   S    EK   LT+ + E   QE        QL    ++H    ++L+ E
Sbjct: 1401 ISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVE 1460

Query: 788  LLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDL 847
            L E  Q+  + G E    +  +R  Q     + +  K  +  +  L    G   +  K L
Sbjct: 1461 LCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSL 1520

Query: 848  QEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNS 907
             + + +  +Q   EKD +    A  QE  ++ L  E   SL+  Q      ++ K  L  
Sbjct: 1521 ADVESQVSAQ-NKEKDTVLGRLALLQE-ERDKLITEMDRSLLENQSLSSSCESLKLALEG 1578

Query: 908  MVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQ 967
            +  ++++L++++E L++    + +       E +  HK EL++  E+L Q+  +    ++
Sbjct: 1579 LTEDKEKLVKEIESLKSSKIAEST-------EWQEKHK-ELQKEYEILLQSYENVSNEAE 1630

Query: 968  RLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATS 1027
            R++ +     QE+QE+  KL + E   K T +       EM     +++   K  QQ   
Sbjct: 1631 RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKI- 1689

Query: 1028 PLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA---HEQAVKENVKM 1084
             L + +   ++  E    GD A   +   E LL  N  +   L+R    +E   K+   +
Sbjct: 1690 -LELEEENDRLRAEVHPAGDTAKECM---ETLLSSNASMKEELERVKMEYETLSKKFQSL 1745

Query: 1085 ATEISRLQQRLQKLEPGLV--MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH 1142
             +E   L + +Q L+  +   +S   +  ATE   N    TE       T+ + G T   
Sbjct: 1746 MSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTE-----EGTQSIPGET--- 1797

Query: 1143 VLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQ 1202
                 E+ +   + +  T S      K   + A  + FS  +       +  +LK +I+ 
Sbjct: 1798 -----EEQDSLSMSTRPTCSESVPSAK-SANPAVSKDFSSHDEINNYLQQIDQLKERIAG 1851

Query: 1203 LQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE---N 1259
            L+E             EK+++  F  ++  +K  +L +I     + K+L E+V++    N
Sbjct: 1852 LEE-------------EKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLN 1898

Query: 1260 DCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENE 1319
              +QEEL  + T+  E  E  K+   E  RL ++L ++      +    +   + +I+NE
Sbjct: 1899 QQIQEELSRV-TKLKETAEEEKDDLEE--RLMNQLAELNGSIGNYC---QDVTDAQIKNE 1952

Query: 1320 ELNVLVLRLQGKIEKLQESVVQ------RCDCCLWEASLENLE--IEPDGNILQLNQTLE 1371
             L   +  L+  + +L+E   Q      + +  + +  LE ++   +  GN     +  E
Sbjct: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE 2012

Query: 1372 ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVIL 1431
                + + V  + ++C    +Y E  + L   VKA E       +QT  ++    +  I 
Sbjct: 2013 LLKEKQQEVKQLQKDC---IRYQEKISALERTVKALEF------VQTESQK----DLEIT 2059

Query: 1432 EENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEK-EEE 1490
            +EN        K  Q +    ++ L+ T+  E  R L + + +   +K++ S+ E  + +
Sbjct: 2060 KENLAQAVEHRKKAQAELASFKVLLDDTQ-SEAARVLADNLKL---KKELQSNKESVKSQ 2115

Query: 1491 LKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGS 1550
            +K    DL+     ++Q  E    E + +Q++   LR E   L  E++I  +++ TLN  
Sbjct: 2116 MKQKDEDLE---RRLEQAEEKHLKEKKNMQEKLDALRREKVHL--EETIGEIQV-TLNKK 2169

Query: 1551 QEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQEL 1610
             +E              VQ++ ENL   +++L                  +++   LQ+ 
Sbjct: 2170 DKE--------------VQQLQENLDSTVTQL---------------AAFTKSMSSLQDD 2200

Query: 1611 NQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTH 1670
              R+ +   +K +   + A++ +E+E   LKE  + C V    L   +   + E+KI   
Sbjct: 2201 RDRVIDE-AKKWERKFSDAIQSKEEE-IRLKE--DNCSVLKDQL-RQMSIHMEELKINIS 2255

Query: 1671 IVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVL-SYNEKLLKEKEALSEELNSCVDK 1729
             ++ +  + + + +   QL         QQK+   L   N++LL + E      +S  ++
Sbjct: 2256 RLEHDKQIWESKAQTEVQL---------QQKVCDTLQGENKELLSQLEETRHLYHSSQNE 2306

Query: 1730 LAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL 1789
            LAK   LE  + ++K +     +     K Q    +  ++  E  +QN      ++++DL
Sbjct: 2307 LAK---LESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDL 2363

Query: 1790 RVTQQEKEALKQEV-MSLHKQLQNAGGKSWAPEIA------THPSGLHNQQKRLSWDKLD 1842
            + +++    L +E+ M   K +    GK  A ++A       H   +   +  LS ++ +
Sbjct: 2364 QASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE 2423

Query: 1843 HL-MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPT 1901
            ++ + EE +    +  +L   ++  K E    + ++     ++           G     
Sbjct: 2424 NIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483

Query: 1902 EQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLME-M 1960
            E+  LS+  E DQ  +E +  N      N L++E+  +    + L  +  KLD +L++  
Sbjct: 2484 EERHLSIILEKDQLIQEAAAEN------NKLKEEIRGLRSHMDDLNSENAKLDAELIQYR 2537

Query: 1961 QHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQH-------LQE 2013
            + L    T   S     L++  QQ   +    ++ +L+ +L ++E  N+        LQE
Sbjct: 2538 EDLNQVITIKDSQQKQLLEVQLQQNKEL--ENKYAKLEEKLKESEEANEDLRRSFNALQE 2595

Query: 2014 ELENRTSE 2021
            E ++ + E
Sbjct: 2596 EKQDLSKE 2603



 Score =  201 bits (512), Expect = 5e-51
 Identities = 360/1776 (20%), Positives = 737/1776 (41%), Gaps = 252/1776 (14%)

Query: 347  ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 406
            E + L+T+         S  +    L   ++ +  +KEKL  +++  +  K   ++E  +
Sbjct: 1547 ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE 1606

Query: 407  HHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQI---LQQAGKQRLELEQEIEK 461
             H  +++  E  L+  +      ERI  +   +R+E++++   L+     + E E+++++
Sbjct: 1607 KHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE 1666

Query: 462  AKTEENYIRDRLALSLKENSRLENELLENAEKL-AEYENLTNKLQRNLENVLAEKFGDLD 520
            A+ E   +++++    K   +   EL E  ++L AE     +  +  +E +L+       
Sbjct: 1667 AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNAS--- 1723

Query: 521  PSSAEFFLQEERLTQMRNEYE---RQCRVLQDQVDELQSELEEYRAQ-----GRVLRLPL 572
                     +E L +++ EYE   ++ + L  + D L  E+++ + Q      +   L  
Sbjct: 1724 --------MKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEA 1775

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                  +      G +   G  +EE + L+MS            +             D+
Sbjct: 1776 TEKHDNQTNVTEEGTQSIPG-ETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHE 692
            + +Y +Q+D+        +E  KQ+++  + TLE + + L ++I+   G+  +L+E   E
Sbjct: 1835 INNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE---E 1890

Query: 693  ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTE 752
             T            K+      +QE+L         +R+T+ + + E E++ L+     +
Sbjct: 1891 VT------------KMNLLNQQIQEEL---------SRVTKLKETAEEEKDDLEERLMNQ 1929

Query: 753  EKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTS 812
              +  L   +  + Q+   + ++   LE E    + L+K   EL+E ++++  E  +  S
Sbjct: 1930 --LAELNGSIGNYCQDVTDAQIKNELLESE---MKNLKKCVSELEEEKQQLVKEKTKVES 1984

Query: 813  QIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEA 872
            +I  ++    Q   +         E   +   K+LQE  +E++     E  +L ++C   
Sbjct: 1985 EIRKEYLEKIQGAQK---------EPGNKSHAKELQELLKEKQQ----EVKQLQKDCIRY 2031

Query: 873  QELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSL 932
            QE +    +  K    V T+ ++ LE T KE+L   V  R++   +L   + + +  QS 
Sbjct: 2032 QEKISALERTVKALEFVQTESQKDLEIT-KENLAQAVEHRKKAQAELASFKVLLDDTQSE 2090

Query: 933  LSDQILELKSSHKRELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAM- 990
             + ++L      K+EL+  +E V  Q    ++   +RLE+ E +H +E++ M  KL A+ 
Sbjct: 2091 AA-RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALR 2149

Query: 991  -ENIH--------KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1041
             E +H        + T    D+E  ++      L S + ++   T  +S LQ     + +
Sbjct: 2150 REKVHLEETIGEIQVTLNKKDKEVQQLQ---ENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206

Query: 1042 E----EVEGDGALSLLQQGEQLLEENGDVL---LSLQRAHEQAVKENVKMATEISRLQQR 1094
            E    E +   A+   ++  +L E+N  VL   L     H + +K N+       ++ + 
Sbjct: 2207 EAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWES 2266

Query: 1095 LQKLEPGLVMSSC--LDEPATEFFGNTAEQTEPF-LQQNRTKQVEGVTR--RHVLSDLED 1149
              + E  L    C  L     E      E    +   QN   ++E   +  +  L+DL +
Sbjct: 2267 KAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSN 2326

Query: 1150 --DEVRDLGSTGTSSVQRQEVKIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQ 1206
              ++ ++        +++QE  I+ S+ S E   ++L+ S E  +    L  +I+  +++
Sbjct: 2327 SLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSR---LHEEINMKEQK 2383

Query: 1207 LMMLCADCDRASEKKQDLLFDVSVLK----KKLKMLERIPEASPKYKLLYEDVSREN-DC 1261
            ++ L       S K++ +   ++ L+    K++K LE +     +  ++ E+ +++  D 
Sbjct: 2384 IISLL------SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1321
              + +  ++T   E ++   +L + V  +       + +   +  LE+ +  + +E ++L
Sbjct: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL 2497

Query: 1322 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1381
               +     +  KL+E + +     + + + EN ++  D  ++Q  + L + +    S  
Sbjct: 2498 ---IQEAAAENNKLKEEI-RGLRSHMDDLNSENAKL--DAELIQYREDLNQVITIKDSQQ 2551

Query: 1382 HVIEECK-QENQYLEGN-TQLLEKVKAHEIAW--LHGTIQTHQERPRVQNQVI--LEENT 1435
              + E + Q+N+ LE    +L EK+K  E A   L  +    QE  +  ++ I  L+ + 
Sbjct: 2552 KQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI 2611

Query: 1436 TLLGFQDKHFQHQATI----AELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEEL 1491
            + L  Q    Q + T+    A+L++++ ++  L+            QK +    E EEEL
Sbjct: 2612 SQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSS------SQKRI---AELEEEL 2662

Query: 1492 KAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQ 1551
              +  +      E++ K   L+ E + L  +  I+RNE  T  E       ++  L    
Sbjct: 2663 VCVQKEAAKKVGEIEDK---LKKELKHLHHDAGIMRNETETAEE-------RVAELARDL 2712

Query: 1552 EEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELN 1611
             EM QK   V +EN  +   +++  + +S L+      D  N EL +   +    L+EL 
Sbjct: 2713 VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQ---NSRDHANEELDELKRKYDASLKELA 2769

Query: 1612 QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHI 1671
            Q   + L  +E++    AL        N  EE            +SL          +H+
Sbjct: 2770 QLKEQGLLNRERD----ALLSETAFSMNSTEE------------NSL----------SHL 2803

Query: 1672 VQQENHLL-KDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKL 1730
             +    LL KDE    + LH    L D   ++ S       L  E++ L  EL    +K 
Sbjct: 2804 EKLNQQLLSKDE----QLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNEL----EKF 2855

Query: 1731 AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLR 1790
             KS   + R A                 +Q   S  +VQ+L+  + ++     R+  +L+
Sbjct: 2856 RKSEEGKQRSA-----------------AQPSTSPAEVQSLKKAMSSLQNDRDRLLKELK 2898

Query: 1791 VTQQEKEALKQEVMSLH---KQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNE 1847
              QQ+   + QE+  LH    QLQ    K+ A +I         +Q+ LSW    H +  
Sbjct: 2899 NLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQE----ELRQENLSWQHELHQLRM 2954

Query: 1848 EQQLLWQENERLQ-----TMVQNTKAELTHSREKVRQLESN------LLPKHQKHLNPSG 1896
            E+   W+ +ER         + +   +L+H +  +R+L S+      L  ++Q+  +P  
Sbjct: 2955 EKS-SWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPET 3013

Query: 1897 TMNPTEQEKL-----SLKRECDQFQKEQSPANRKVSQMNS----LEQELETIHLE----N 1943
            + +P   + L      L+ + +   KE      ++ Q+NS    L +E  T+ ++    +
Sbjct: 3014 SASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTS 3073

Query: 1944 EGLKKKQ----------VKLDEQLMEMQ--HLRSTATPSPSPHAWDLQLLQQQACPMVPR 1991
            + L++ Q            L++Q+ E+Q   L     P        +           P+
Sbjct: 3074 QSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQ 3133

Query: 1992 EQFLQLQRQLL----QAERINQHLQEELENRTSETN 2023
            + F + Q+QL     +   + + L+EE + R +  N
Sbjct: 3134 QSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAEN 3169



 Score =  197 bits (501), Expect = 9e-50
 Identities = 385/1784 (21%), Positives = 741/1784 (41%), Gaps = 291/1784 (16%)

Query: 373  LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAA 432
            L++ D+ ++E+ K   +  K +KLK    +++   +  IE         L  E +     
Sbjct: 75   LQQKDEALQEERKAADN--KIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL 132

Query: 433  LKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAE 492
             K++     E++  +  K +L+ ++E+    T +  +    A    ++S    E +   +
Sbjct: 133  SKHDKSSTEEEMEIEKIKHKLQEKEEL--ISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQ 190

Query: 493  KLAEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFLQ----EERLTQMRNEYERQCRV 546
            +L E E   + LQ  L    AE+     +    A F  Q    E+ L Q+  + + +   
Sbjct: 191  QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETE- 249

Query: 547  LQDQVDELQSELEEYRAQ--GRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMS 604
            +Q ++  LQ +LEE+     GR   + L        E  +  +  +      E N L  +
Sbjct: 250  MQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNT 309

Query: 605  IEAE-----LVIEQMK-EQHHRDICC--LRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 656
            +E E     +++E+M+ E   R +    L+ E+   +  +E Q  +     +     ++Q
Sbjct: 310  VETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE-QAGQAQAELESRYSALEQ 368

Query: 657  RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
            +H+ E       I  L+    ELQ     LK+ + +      E+  Q    +++ +  LQ
Sbjct: 369  KHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQ 428

Query: 717  EKLR----LQHEMELKARLTQAQASF-EREREGLQSSAWTEEKVRGLTQELEQFHQEQLT 771
            +K +      + + L+   T +Q SF +   EG Q  A TEE +  L + + +   E+  
Sbjct: 429  QKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQ--AVTEENIASLQKRVVELENEKGA 486

Query: 772  SLVEKHTLEKEELRKE---------LLEKHQRELQEGREKMETE----CNRRTSQIEAQF 818
             L+   ++E EEL+ E         LLE   R  +  RE  E       N+R+S  E   
Sbjct: 487  LLLS--SIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE--- 541

Query: 819  QSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE---L 875
                    E  +  L++   +  +EL  L  + +E + +  F K +L  + AE  +   L
Sbjct: 542  --------ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL 593

Query: 876  LKETLKREKTTSLVLTQEREMLEKTYK-------EHLNSMVVERQQLLQDLEDLRNVSET 928
             ++ +K+ +   +   + +  LE T +       E  +   VE++Q   + +     S T
Sbjct: 594  DQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQ-----SRT 648

Query: 929  QQSL-LSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKL 987
             + + L+D  +ELKS+ +    + ++ L       Q     LERL+           S++
Sbjct: 649  SEEISLNDAGVELKSTKQ----DGDKSLSAVPDIGQCHQDELERLK-----------SQI 693

Query: 988  LAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEG 1046
            L +E N HKA  E  ++   E + EIS L   I+E ++     S   S    + EE  + 
Sbjct: 694  LELELNFHKAQ-EIYEKNLDEKAKEISNLNQLIEEFKKNADNNS---SAFTALSEERDQL 749

Query: 1047 DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGL---- 1102
               +  L    +L  +   + ++L  A  Q   +        + L +++  L        
Sbjct: 750  LSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD 809

Query: 1103 ----VMSSCLDEPATEFFGNTA--EQTEPFLQQNRTKQVEGVTR-RHVLS---------- 1145
                V+ + LD+   +F   +      +  LQ   ++ +EG  R RH+ S          
Sbjct: 810  VKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALS 869

Query: 1146 --DLEDDEVRDLGSTGTSSVQRQEVKIEESEASVE--GFSELENSEETRTESWELKNQIS 1201
              +LE  ++  L       V+  +  IEE +  V    FS  E   +   E + L  +I 
Sbjct: 870  QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929

Query: 1202 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
             L+EQL +L     RA E K++ + + + +   LK  +   E SP  ++  E++  E D 
Sbjct: 930  TLKEQLNLL----SRAEEAKKEQVEEDNEVSSGLK--QNYDEMSPAGQISKEELQHEFDL 983

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1321
            L++E    + +   AL N KEL   V RL++EL  +++ ++  + L ++ +  ++E ++ 
Sbjct: 984  LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSET-ERGEVEEDKE 1042

Query: 1322 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1381
            N          E  ++ V  +C     E  L+    E +  +  + + LEE +       
Sbjct: 1043 NK---------EYSEKCVTSKCQEI--EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091

Query: 1382 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ---THQERPRVQNQVILEENTTLL 1438
             ++   KQ NQ L+  T  ++ ++A EI+     IQ   T        + V L + T ++
Sbjct: 1092 ALV---KQMNQTLQDKTNQIDLLQA-EISENQAIIQKLITSNTDASDGDSVALVKETVVI 1147

Query: 1439 G----FQDKHFQHQATIAELELEKTKLQELTRKLKERVT----ILVKQKDVLSHGEKEEE 1490
                    +H++ +     L LEK K ++L +KL+E +T    IL K ++   H    EE
Sbjct: 1148 SPPCTGSSEHWKPELEEKILALEKEK-EQLQKKLQEALTSRKAILKKAQEKERH--LREE 1204

Query: 1491 LKAMMHD---LQITCSEMQQKVELLRYESEKLQ-QENSILRNEITTLNEEDSISNLKLGT 1546
            LK    D   LQ    E  ++ E +  +  +LQ Q    +  ++ + ++++S S+     
Sbjct: 1205 LKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTP--- 1261

Query: 1547 LNGSQEEMWQKTE-----------------TVKQENAAVQ--KMVENLKKQISELKIKNQ 1587
              G +E +++ TE                 +  ++ +A+Q    V  +K Q+ E++ +  
Sbjct: 1262 --GLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV 1319

Query: 1588 QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERC 1647
            +L+L+ +  + + ++  E++ +L +++ +     E E   +   E E    +L+++LE  
Sbjct: 1320 ELELKVSSTTSELTKKSEEVFQLQEQINKQ--GLEIESLKTVSHEAEVHAESLQQKLESS 1377

Query: 1648 KVQSSTL-----------------------VSSLEAELSE-----VKIQTHIVQQENHL- 1678
            ++Q + L                       VS L  +LSE      KIQT I++QE+ + 
Sbjct: 1378 QLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIK 1437

Query: 1679 ---------LKDELEKMKQLH-------RCPD--------LSDFQQKISSVLSYNEKLLK 1714
                      K+  E++KQL        + P+            Q+K+ + L   ++ LK
Sbjct: 1438 ALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALK 1497

Query: 1715 EKEALSEELN---SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNL 1771
            E ++L EEL+     +++L KS      +A ++ +  +   +  ++  +L   QE+   L
Sbjct: 1498 ENKSLQEELSLARGTIERLTKS------LADVESQVSAQNKEKDTVLGRLALLQEERDKL 1551

Query: 1772 -----EDTVQNVNLQMS--RMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT 1824
                    ++N +L  S   +K  L    ++KE L +E+ SL K  + A    W      
Sbjct: 1552 ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL-KSSKIAESTEW------ 1604

Query: 1825 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1884
                   Q+K     K   ++ +  + +  E ER+Q +V+  + E      K+R  E+N 
Sbjct: 1605 -------QEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657

Query: 1885 LPKHQKHLNPSGTM-----------NPTEQEKLSLKRECDQFQKEQSPA--------NRK 1925
                ++       M              +Q+ L L+ E D+ + E  PA           
Sbjct: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717

Query: 1926 VSQMNSLEQELETIHLENEGLKKK-------QVKLDEQLMEMQH 1962
            +S   S+++ELE + +E E L KK       +  L E++ +++H
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKH 1761



 Score =  174 bits (442), Expect = 6e-43
 Identities = 374/1831 (20%), Positives = 745/1831 (40%), Gaps = 301/1831 (16%)

Query: 403  EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKA 462
            E+++   A+E+  E   +KL E    R A LK    KER             L +E+++ 
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH------------LREELKQQ 1208

Query: 463  KTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS 522
            K + N ++++     KEN  + ++L +   ++   E++  KL    +         L+  
Sbjct: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQL--QIQVRESIDGKLPSTDQQESCSSTPGLEEP 1266

Query: 523  SAEFFLQEERLTQMRNE---------YERQCRVLQD--QVDELQSELEEYRAQGRVLRLP 571
               F   E+  TQ   E         +      LQ    V +++++L+E  A+   L L 
Sbjct: 1267 L--FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELK 1324

Query: 572  LKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDI------CCL 625
            + ++ SE  + +    + +     E+ N   + IE+   +    E H   +        L
Sbjct: 1325 VSSTTSELTKKSEEVFQLQ-----EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQL 1379

Query: 626  RLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 685
            ++   + +R  + +LDE      K +E++      +    E  ++ ++ EI E +     
Sbjct: 1380 QIAGLEHLRELQPKLDELQKLISKKEEDVSYL-SGQLSEKEAALTKIQTEIIEQEDLIKA 1438

Query: 686  LKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA-QASFEREREG 744
            L          H+E  KQLQV+L E K   +E   +  E   K ++ +  QA+    +E 
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQKPEE---IGEESRAKQQIQRKLQAALISRKEA 1495

Query: 745  LQSSAWTEEKV---RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE 801
            L+ +   +E++   RG  + L +   + + S V     EK+ +   L       LQE R+
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLAD-VESQVSAQNKEKDTVLGRLAL-----LQEERD 1549

Query: 802  KMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG------RYRQELKDLQEQQREEK 855
            K+ TE +R  S +E Q       ++  CES   +LEG      +  +E++ L+  +  E 
Sbjct: 1550 KLITEMDR--SLLENQ------SLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAES 1601

Query: 856  SQWEFEKDELTQE----CAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE 911
            ++W+ +  EL +E        + +  E  + +     V  +++E+  K      N    E
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661

Query: 912  RQ--QLLQDLEDLRNVSETQQSLLSDQILELKSSHKR----------ELREREEVLCQAG 959
            +Q  +  Q++E+++            +ILEL+  + R            +E  E L  + 
Sbjct: 1662 KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721

Query: 960  ASEQLASQRLERLEMEHD---QERQEMMSKLLAME------------NIHK-ATCETADR 1003
            AS +   + LER++ME++   ++ Q +MS+  ++             N+ K A  E  ++
Sbjct: 1722 ASMK---EELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEK 1778

Query: 1004 ERAEMSTEISRLQSKIKEMQQATSPLSM------------LQSGCQVIGEEEVEGDGALS 1051
               + +      QS   E ++  S LSM             +S    + ++    D   +
Sbjct: 1779 HDNQTNVTEEGTQSIPGETEEQDS-LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837

Query: 1052 LLQQGEQLLEENGDVLLSLQRAHE-QAVKENVK--MATEISRLQQRLQKLEPGLVMSSCL 1108
             LQQ +QL E    +    Q+  E     EN K  + ++IS     L+ L+  +   + L
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897

Query: 1109 DEPATEFFGN------TAEQTEPFLQQNRTKQV-----------EGVTRRHVLSDLEDDE 1151
            ++   E          TAE+ +  L++    Q+           + VT   + ++L + E
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957

Query: 1152 VRDLGSTGTSSVQRQEVKIEE-----SEASVEGFSELENSEE---TRTESWELKNQISQL 1203
            +++L    +   + ++  ++E     SE   E   +++ +++    ++ + EL+  + + 
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEK 2017

Query: 1204 QEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK---------------- 1247
            Q+++  L  DC R  EK       +S L++ +K LE +   S K                
Sbjct: 2018 QQEVKQLQKDCIRYQEK-------ISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070

Query: 1248 ---------YKLLYEDVSREND-CLQEELRMMETRYDEALENNKELTAEVFRLQDE--LK 1295
                     +K+L +D   E    L + L++ +      L++NKE      + +DE   +
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKE-----LQSNKESVKSQMKQKDEDLER 2125

Query: 1296 KMEEVTETFLSLEKSYDE---------VKIENE--ELNVLVLRLQGKIEKLQESVVQRC- 1343
            ++E+  E  L  +K+  E         V +E    E+ V + +   ++++LQE++     
Sbjct: 2126 RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL-- 1401
                +  S+ +L+ + D       + ++E     R     I+  ++E +  E N  +L  
Sbjct: 2186 QLAAFTKSMSSLQDDRD-------RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2238

Query: 1402 ---------EKVKA------HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKH 1444
                     E++K       H+        QT  +  +     +  EN  LL    + +H
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298

Query: 1445 FQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSE 1504
              H +     + E  KL+   + LK+++T      D+ +  EK +E K    +L+    +
Sbjct: 2299 LYHSS-----QNELAKLESELKSLKDQLT------DLSNSLEKCKEQKG---NLEGIIRQ 2344

Query: 1505 MQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQE 1564
             +  ++  ++  E+L+ +    R   + L+EE ++   K+ +L   +EE  Q        
Sbjct: 2345 QEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQ-------- 2396

Query: 1565 NAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKE 1624
              A+ ++ +   K+I EL+    Q + EN  L ++N +  +K  +L + L  +  +KE  
Sbjct: 2397 -VAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTI--KKENI 2453

Query: 1625 PGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKD 1681
               + L+   +   +L+ + +R       L    E  LS +  +  ++Q+   EN+ LK+
Sbjct: 2454 QQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE---ERHLSIILEKDQLIQEAAAENNKLKE 2510

Query: 1682 ELEKMKQLHRCPDLSDFQQKISS-VLSYNEKL---LKEKEALSEELNSCVDKLAKSSLLE 1737
            E+  ++      DL+    K+ + ++ Y E L   +  K++  ++L     +L ++  LE
Sbjct: 2511 EIRGLRS--HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV--QLQQNKELE 2566

Query: 1738 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE-- 1795
            ++ A ++++ K  E  +  L+    A QE+ Q+L   ++++ + +S++   +   Q+E  
Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626

Query: 1796 ----KEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQL 1851
                   LK +   +H+   +A   S    IA     L   QK  +       + E +  
Sbjct: 2627 LGLYHAQLKVKEEEVHR--LSALFSSSQKRIAELEEELVCVQKEAA-----KKVGEIEDK 2679

Query: 1852 LWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE 1911
            L +E + L       + E   + E+V +L  +L+   QK L  +        +  S  R 
Sbjct: 2680 LKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRS 2739

Query: 1912 CDQFQKEQSPANRKVSQM-NSLEQEL-ETIHLENEGLKKKQVKLDEQLMEMQHLRSTATP 1969
                Q  +  AN ++ ++    +  L E   L+ +GL  ++   D  L E     ++   
Sbjct: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE--RDALLSETAFSMNSTEE 2797

Query: 1970 SPSPHAWDLQLLQQQACPMVPREQFLQLQRQL----------------LQAERINQHLQE 2013
            +   H   L+ L QQ   +   EQ L L  QL                LQ ER   HL  
Sbjct: 2798 NSLSH---LEKLNQQL--LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER--DHLWN 2850

Query: 2014 ELE--NRTSETNTPQALLPEQRAVHADSYRR 2042
            ELE   ++ E     A  P        S ++
Sbjct: 2851 ELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881



 Score =  141 bits (355), Expect = 7e-33
 Identities = 291/1452 (20%), Positives = 573/1452 (39%), Gaps = 215/1452 (14%)

Query: 415  NEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            N Y L+++D+  KERIA L+ E +K +E   Q    ++  L  +I     E   +++ + 
Sbjct: 1836 NNY-LQQIDQ-LKERIAGLEEEKQKNKE-FSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
                 N +++ EL    +     E   + L+  L N LAE  G +       + Q+    
Sbjct: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGN-----YCQDVTDA 1947

Query: 535  QMRNEY-ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGL 593
            Q++NE  E + + L+  V EL+ E ++           +K     E E     +E   G 
Sbjct: 1948 QIKNELLESEMKNLKKCVSELEEEKQQL----------VKEKTKVESEIRKEYLEKIQGA 1997

Query: 594  GSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQEN 653
              E  N  +     EL+ E+ +E       C+R +  +K+      L+ TV + +  Q  
Sbjct: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ--EKI----SALERTVKALEFVQTE 2051

Query: 654  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEAT---CRHEEEKKQLQVKLEE 710
             ++  E     L + +   K   AEL     +L +   EA      + + KK+LQ   E 
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111

Query: 711  EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQE-- 768
             K+ +++K     + +L+ RL QA+    +E++ +Q      EK+  L +E     +   
Sbjct: 2112 VKSQMKQK-----DEDLERRLEQAEEKHLKEKKNMQ------EKLDALRREKVHLEETIG 2160

Query: 769  QLTSLVEKHTLEKEELRKEL---------LEKHQRELQEGREKMETECNRRTSQIEAQFQ 819
            ++   + K   E ++L++ L           K    LQ+ R+++  E  +   +     Q
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220

Query: 820  SDCQKVTERCESALQSLEGRYRQ------ELKDLQEQQREEKSQWEFEKDELTQECAEAQ 873
            S  +++  + E     L+ + RQ      ELK    +   +K  WE +     Q   + Q
Sbjct: 2221 SKEEEIRLK-EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESK----AQTEVQLQ 2275

Query: 874  ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET----- 928
            + + +TL+ E    L   +E   L  + +  L  +  E + L   L DL N  E      
Sbjct: 2276 QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQK 2335

Query: 929  --------------QQSLLSDQILELKSSHKRELRER---------EEVLCQAGASEQLA 965
                          Q S  S + LE      REL  R         ++++      E+  
Sbjct: 2336 GNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAI 2395

Query: 966  SQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKE--MQ 1023
               +  L  +HD+E +E+   LL+ E       E  +++  + + ++      IK+  +Q
Sbjct: 2396 QVAIAELRQQHDKEIKEL-ENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQ 2454

Query: 1024 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVK 1083
            Q     S ++S   +  + +        ++   +QL E +  ++L   +  ++A  EN K
Sbjct: 2455 QKAQLDSFVKSMSSLQNDRD-------RIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507

Query: 1084 MATEISRLQQRLQ-------KLEPGLVM-SSCLDEPATEFFGNTAEQTEPFLQQNRTKQV 1135
            +  EI  L+  +        KL+  L+     L++  T       +  E  LQQN+  + 
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567

Query: 1136 EGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWE 1195
            +       L + E+    DL  +  +  + ++   +E E+     S+L        E   
Sbjct: 2568 KYAKLEEKLKESEEAN-EDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626

Query: 1196 LKNQISQL---QEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1252
            L    +QL   +E++  L A    + ++  +L  ++  ++K+    +++ E   K K   
Sbjct: 2627 LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA--KKVGEIEDKLKKEL 2684

Query: 1253 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETF----LSLE 1308
            + +  +   ++ E    E R  E   +  E+  ++  +  E K +    ++F     SL+
Sbjct: 2685 KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQ 2744

Query: 1309 KSYDEVKIENEELN---------VLVLRLQGKIEKLQESVVQRCDCCL---WEASLENLE 1356
             S D    E +EL          +  L+ QG + + +++++      +    E SL +LE
Sbjct: 2745 NSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLE 2804

Query: 1357 ------IEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIA 1410
                  +  D  +L L+  LE+   +V+S    +   + E  +L      LEK +  E  
Sbjct: 2805 KLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE---LEKFRKSEEG 2861

Query: 1411 WLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKE 1470
                  Q       VQ+  + +  ++L   +D+          L  E   LQ+   ++ +
Sbjct: 2862 KQRSAAQPSTSPAEVQS--LKKAMSSLQNDRDR----------LLKELKNLQQQYLQINQ 2909

Query: 1471 RVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI 1530
             +T L                    H L+    E Q K +  +   E+L+QEN   ++E+
Sbjct: 2910 EITEL--------------------HPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHEL 2949

Query: 1531 TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE---LKIKNQ 1587
              L  E S   +    +   +E+         Q+ + +Q ++  L+   S+   LK++ Q
Sbjct: 2950 HQLRMEKSSWEIHERRM---KEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQ 3006

Query: 1588 QLDLENTELSQKNSQN----------------------QEKLQELNQRLTEMLCQK---- 1621
            +     T  S   SQN                      + ++Q+LN   +++L +K    
Sbjct: 3007 RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLS 3066

Query: 1622 -EKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHL-L 1679
             +    + +L E +Q   +L   L  C V     V  L+A    + +     Q++N +  
Sbjct: 3067 IQLCDTSQSLRENQQHYGDL---LNHCAVLEKQ-VQELQAGPLNIDVAPGAPQEKNGVHR 3122

Query: 1680 KDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHR 1739
            K + E++++  +    S+ QQ++ +     +++ + ++ L EE +  V      S+ E +
Sbjct: 3123 KSDPEELREPQQ--SFSEAQQQLCNT---RQEVNELRKLLEEERDQRVAAENALSVAEEQ 3177

Query: 1740 IATMKQEQKSWE 1751
            I  +  E   W+
Sbjct: 3178 IRRL--EHSEWD 3187



 Score =  131 bits (330), Expect = 6e-30
 Identities = 288/1451 (19%), Positives = 590/1451 (40%), Gaps = 227/1451 (15%)

Query: 307  VERILDTWQEEGIENSQEILKALDFSLDGNIN--LTELTLA-LENELLVTKNSIHQAALA 363
            V ++ +T +EE  +  + ++  L   L+G+I     ++T A ++NELL       ++ + 
Sbjct: 1908 VTKLKETAEEEKDDLEERLMNQLA-ELNGSIGNYCQDVTDAQIKNELL-------ESEMK 1959

Query: 364  SFKAEIRHLLERVDQVVREKEKLRSDLDK--AEKLKSLMASEVDDHHA----AIERRNEY 417
            + K  +  L E   Q+V+EK K+ S++ K   EK++       +  HA     + +  + 
Sbjct: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ 2019

Query: 418  NLRKLDEE---YKERIAAL----------KNELRKERE---QILQQAGKQRLELEQEIEK 461
             +++L ++   Y+E+I+AL          + E +K+ E   + L QA + R + + E+  
Sbjct: 2020 EVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS 2079

Query: 462  AKTEENYIRDRLALSLKENSRLENELLENAEKLAEY-----ENLTNKLQRNLENVLAEKF 516
             K   +  +   A  L +N +L+ EL  N E +        E+L  +L++  E  L EK 
Sbjct: 2080 FKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK 2139

Query: 517  G---DLDPSSAEFFLQEERLTQMR---NEYERQCRVLQDQVDELQSELEEYRA------- 563
                 LD    E    EE + +++   N+ +++ + LQ+ +D   ++L  +         
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199

Query: 564  -QGRVLRLPLK--NSPSEEVEANSGGIEPEHGLGSEECNPL-----NMSIE-AELVIEQM 614
             + RV+    K     S+ +++     E E  L  + C+ L      MSI   EL I   
Sbjct: 2200 DRDRVIDEAKKWERKFSDAIQSK----EEEIRLKEDNCSVLKDQLRQMSIHMEELKINIS 2255

Query: 615  KEQHHRDI----CCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQIS 670
            + +H + I        ++L+ KV    +  ++ ++S  +   ++    +NE   LE ++ 
Sbjct: 2256 RLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELK 2315

Query: 671  DLKNEIAELQGQAAVLKE--AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELK 728
             LK+++ +L       KE   + E   R +E   Q       + ++ Q +  LQ   EL 
Sbjct: 2316 SLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ-----NSKFSYEQLETDLQASRELT 2370

Query: 729  ARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL 788
            +RL +     E++   L S    EE ++    EL Q H +++  L E    ++EE    L
Sbjct: 2371 SRLHEEINMKEQKIISLLSG--KEEAIQVAIAELRQQHDKEIKEL-ENLLSQEEEENIVL 2427

Query: 789  LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848
             E++++ + +  + MET    +   I+ + Q D      +  S+LQ+   R   + + L+
Sbjct: 2428 EEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS---FVKSMSSLQNDRDRIVGDYQQLE 2484

Query: 849  EQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSM 908
            E+          EKD+L QE A     LKE ++  ++    L  E   L+          
Sbjct: 2485 ERH----LSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLD---------- 2530

Query: 909  VVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQR 968
              E  Q  +DL  +  + ++QQ     Q+LE++    +EL  +                +
Sbjct: 2531 -AELIQYREDLNQVITIKDSQQK----QLLEVQLQQNKELENK--------------YAK 2571

Query: 969  LERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSP 1028
            LE    E ++  +++     A++            E+ ++S EI  L+  I ++ +  + 
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQ-----------EEKQDLSKEIESLKVSISQLTRQVTA 2620

Query: 1029 LSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEI 1088
            L               + +G L L     ++ EE                 E  +++   
Sbjct: 2621 L---------------QEEGTLGLYHAQLKVKEE-----------------EVHRLSALF 2648

Query: 1089 SRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE 1148
            S  Q+R+ +LE  LV   C+ + A +  G   ++ +  L+        G+ R    ++  
Sbjct: 2649 SSSQKRIAELEEELV---CVQKEAAKKVGEIEDKLKKELK--HLHHDAGIMRNE--TETA 2701

Query: 1149 DDEVRDLGSTGTSSVQRQEVKIEESE---ASVEGFSELENSEETRTESWELKNQISQLQE 1205
            ++ V +L        Q+  +  +E++   A ++ F    +S         L+N      E
Sbjct: 2702 EERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS---------LQNSRDHANE 2752

Query: 1206 QLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEE 1265
            +L       D    K    L +++ LK++  +L R  +A     LL E     N   +  
Sbjct: 2753 EL-------DELKRKYDASLKELAQLKEQ-GLLNRERDA-----LLSETAFSMNSTEENS 2799

Query: 1266 LRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV 1325
            L  +E    + L  +++L     +L+D   +++  ++   SL+   D +  E E+     
Sbjct: 2800 LSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR--- 2856

Query: 1326 LRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECV---PRVRSVHH 1382
               +GK     +      +    + ++ +L+ + D  + +L    ++ +     +  +H 
Sbjct: 2857 KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHP 2916

Query: 1383 VIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERP--RVQNQVILEENTTLLGF 1440
            +  + ++     +    + E+++   ++W H   Q   E+    +  + + E+    +  
Sbjct: 2917 LKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISD 2976

Query: 1441 QDKHFQH-QATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQ 1499
            +D+   H Q  I EL    ++ Q L  + + + +    +      G +      ++++ +
Sbjct: 2977 KDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQAS---PETSASPDGSQN-----LVYETE 3028

Query: 1500 ITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTE 1559
            +  +++   ++ +  +  ++QQ NS      + L EE +  +++L   + S  E  Q   
Sbjct: 3029 LLRTQLNDSLKEIHQKELRIQQLNS----NFSQLLEEKNTLSIQLCDTSQSLRENQQHYG 3084

Query: 1560 TVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN----SQNQEKLQELNQRLT 1615
             +    A        L+KQ+ EL+     +D+      +KN      + E+L+E  Q  +
Sbjct: 3085 DLLNHCAV-------LEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFS 3137

Query: 1616 E---MLCQKEKEPG--NSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTH 1670
            E    LC   +E       LEE   ++   +  L   + Q   L  S E + S   I   
Sbjct: 3138 EAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHS-EWDSSRTPIIGS 3196

Query: 1671 IVQQENHLLKD 1681
               QE  LL D
Sbjct: 3197 CGTQEQALLID 3207



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 59/290 (20%), Positives = 127/290 (43%), Gaps = 46/290 (15%)

Query: 1757 LKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEAL-----------KQEVMS 1805
            ++ +L  +++ V  L+D ++  ++Q+ +    L   Q+E++A            K ++ S
Sbjct: 50   VQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL---QEERKAADNKIKKLKLHAKAKLTS 106

Query: 1806 LHKQLQN--AGGKSWAP-------EIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1856
            L+K ++   A G +  P       +++ H     + ++ +  +K+ H + E+++L+    
Sbjct: 107  LNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKS--STEEEMEIEKIKHKLQEKEELI---- 160

Query: 1857 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQ 1916
              LQ   Q T+A+     +   ++E  ++ K Q        +   E+   +L+ +  Q Q
Sbjct: 161  STLQA--QLTQAQAEQPAQSSTEMEEFVMMKQQ--------LQEKEEFISTLQAQLSQTQ 210

Query: 1917 KEQSPANRKVSQMNSLEQELETIHLENEGLK-----KKQVKLDEQLMEMQHLRSTATPSP 1971
             EQ+ A + V + ++  +    +H E+E L+       + ++ ++L  +Q        S 
Sbjct: 211  AEQA-AQQVVREKDARFETQVRLH-EDELLQLVTQADVETEMQQKLRVLQRKLEEHEESL 268

Query: 1972 SPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSE 2021
               A  + LLQQ+      R Q L  Q Q ++AE        E E   S+
Sbjct: 269  VGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESK 318


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  197 bits (502), Expect = 7e-50
 Identities = 391/1872 (20%), Positives = 778/1872 (41%), Gaps = 251/1872 (13%)

Query: 304  HASVERILDTWQEEGIENSQEILKALDFSLDGNIN-LTELTLALENELLVTKNSIHQAAL 362
            +  +E  +  +Q + +E  +++   L+  L    N +T+LT  ++ +  V K+ +    L
Sbjct: 662  YKQMENDIQLYQSQ-LEAKKKMQVDLEKELQSAFNEITKLTSLIDGK--VPKDLLCNLEL 718

Query: 363  ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEY----- 417
               + +I  L + +++ V E E LR ++    +LKSL  SEV+     I+ ++E      
Sbjct: 719  ---EGKITDLQKELNKEVEENEALREEVILLSELKSL-PSEVERLRKEIQDKSEELHIIT 774

Query: 418  -NLRKLDEE--YKE-RIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRL 473
                KL  E  +KE R+  L  E+ K ++ +       +   +QE +  KT       + 
Sbjct: 775  SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYK-STDQEFQNFKTLHMDFEQKY 833

Query: 474  ALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL 533
             + L+EN R+  E++  +++  ++++    L+  L    + K  +L   + E   +   +
Sbjct: 834  KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL----SYKTQELQEKTREVQERLNEM 889

Query: 534  TQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHG- 592
             Q++ + E +   LQ    E +  L   + Q  +  +       ++++     ++ E   
Sbjct: 890  EQLKEQLENRDSTLQTV--EREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947

Query: 593  LGSEECNPLNMSIEAELVIEQMKE---QHHRDICCLRLELEDKVR---HYEKQLDETVVS 646
            L S+  + +NM+I+ +  +    E   QH   I  L+ ++ ++V    H E+   ET   
Sbjct: 948  LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007

Query: 647  CKKAQENMKQRHENETHTLEKQISDLK-NEIAELQGQAAVLKEAHHEATCRHEE---EKK 702
             ++    + ++ + E    +   +D+K NEI E Q +   L +  +E     E    EK+
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067

Query: 703  QLQVKLEEE---KTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSS-----AWTEE 753
            QL+  L+E        QE+LRL   E++ +  +   + +   ++EG  S      A  EE
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127

Query: 754  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
            K++  +Q+L++  Q+ L    E   ++K+    E L+   +  +   E METE      +
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187

Query: 814  IEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ---ECA 870
            +   ++       ER    L+ L+  +  E   L+   RE ++     K+EL        
Sbjct: 1188 LNENYEEVKSITKER--KVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLK 1245

Query: 871  EAQELLKETLKR--EKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 928
            E QE + E  +   EKT  ++ TQ+ E      +E +  ++ E Q+LL ++++   VSET
Sbjct: 1246 EHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI-PVLHEEQELLPNVKE---VSET 1301

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM-EHDQERQEMMSKL 987
            Q+++   ++L  +S+ K               S  LA   +ERL + E  QE QE +  L
Sbjct: 1302 QETMNELELLTEQSTTKD--------------STTLARIEMERLRLNEKFQESQEEIKSL 1347

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ-QATSPLSMLQSG---CQVIGEEE 1043
                +  K   E  + +  ++   I    +KI+E Q +    L+M +      +++ E E
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEME 1407

Query: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
                   +LL+   ++L     +   LQ +H++ +K   K   ++ RLQ+ LQ       
Sbjct: 1408 QFKPKDSALLRIEIEML----GLSKRLQESHDE-MKSVAKEKDDLQRLQEVLQS------ 1456

Query: 1104 MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1163
             S  L E   E      E  E     +   + +  T   +  +L + E      T  S++
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE------TEISTI 1510

Query: 1164 QRQEVKIEESEASVEGFSELENSEETRTESWELKN--QISQLQEQLMMLCADCDRASEKK 1221
            Q+Q   I +         +L+N  +   E  E  N  QIS++QE++  L    +    K 
Sbjct: 1511 QKQLEAIND---------KLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD 1561

Query: 1222 QDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNK 1281
              L    S+  K L++  R+ E+  + +++ ++   E   +QE L++     D+  EN K
Sbjct: 1562 SALQ---SIESKMLELTNRLQESQEEIQIMIKE-KEEMKRVQEALQIER---DQLKENTK 1614

Query: 1282 ELTAEVFRLQD---ELKKMEEVTET------FLSLEKSYDEVKIENEELNVLVLRL---- 1328
            E+ A++   Q+   +  KM  V ET         L++ ++  K+  E +    +RL    
Sbjct: 1615 EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQIL 1674

Query: 1329 QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECK 1388
               +E+++    +R D    E   E L++E D    QL + L E + R        EE K
Sbjct: 1675 HENLEEMRSVTKERDDLRSVE---ETLKVERD----QLKENLRETITRDLEKQ---EELK 1724

Query: 1389 QENQYLEGNTQLLEKV------KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQD 1442
              + +L+ + + ++K+      K +EI+ +   ++   +  + Q+  I EE    L    
Sbjct: 1725 IVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE----LRIAH 1780

Query: 1443 KHF-QHQATI------------------AELELEKTKLQELTRKLKERVTILVKQKDVLS 1483
             H  + Q TI                   +LE    KLQE  ++LK     L+  K  ++
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVN 1840

Query: 1484 HGEKE----EELKAMMHDLQITCSEMQ-------QKVELLRYESEKLQQENSILRNEITT 1532
              +K+    E+LK  + D  +T S+++       QK+     E + + +E   LR    T
Sbjct: 1841 ETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEET 1900

Query: 1533 LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1592
            L  E       L        E+ Q+ +T +  +   ++ V+ L+++ISE   K  Q+   
Sbjct: 1901 LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISE---KTIQISDI 1957

Query: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEK-EPGNSALEEREQEKFNLKEE---LERCK 1648
              +L +   + Q+K+QEL ++  ++L  KE     +  + E EQ K   + +   ++  +
Sbjct: 1958 QKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVR 2017

Query: 1649 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ---LHRCPDLSDFQQKISSV 1705
            + +  L   L   L E++    IV +E    +DEL ++K+   + R   ++  ++ I+  
Sbjct: 2018 MDNFQLTKKLHESLEEIR----IVAKE----RDELRRIKESLKMERDQFIATLREMIARD 2069

Query: 1706 LSYNEKLLKEKEALSEE----LNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1761
               N ++  EK  LS+       S  +K ++   L  R + M    +     S  L+ ++
Sbjct: 2070 -RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128

Query: 1762 VASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPE 1821
               +E    ++  +    LQ   ++      Q+       E   + K+L+     S+  +
Sbjct: 2129 EFQKELSMRVKANLSLPYLQTKHIEKLFTANQR----CSMEFHRIMKKLKYV--LSYVTK 2182

Query: 1822 IATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE---------NERLQTMVQNTKAELTH 1872
            I       H    +   D +D +  +++ L+  +         +  L+ +  N   +L H
Sbjct: 2183 IKEEQ---HESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL-H 2238

Query: 1873 SREKVRQLESNLLP----KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQ 1928
              E ++    +  P    + Q+ L+    M    +E L+ + + ++ +      N ++ Q
Sbjct: 2239 IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ 2298

Query: 1929 MNSL--------------------------EQELETIHLENEGLKKKQVKLDEQLMEMQH 1962
            +N+                           EQ+L+++  +NE L K    L   L     
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ 2358

Query: 1963 LRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSET 2022
            +  T   + +PH              +  E+  +L+  L +A+    H + ++     E 
Sbjct: 2359 VNPTTQDNKNPHV-------TSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKEL 2411

Query: 2023 NTPQALLPEQRA 2034
                 ++ + +A
Sbjct: 2412 EVTNDIIAKLQA 2423



 Score =  192 bits (487), Expect = 4e-48
 Identities = 374/1797 (20%), Positives = 747/1797 (41%), Gaps = 338/1797 (18%)

Query: 377  DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 436
            + +  E   LR+D D        + +E ++    ++ +N+     LDE       AL+ +
Sbjct: 494  ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKND-----LDE-----FEALERK 543

Query: 437  LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAE 496
             +K++E          ++L  EI   K   N ++         N  LENEL    E L E
Sbjct: 544  TKKDQE----------MQLIHEISNLK---NLVKHAEVY----NQDLENELSSKVELLRE 586

Query: 497  YENLTNKLQ-----RNLENVLAEKFGDL----DPSSAEFFLQEERLTQMRNEYERQCRVL 547
             E+   KLQ     + LEN+  +    L    DP   +  L +     +  + +R+   L
Sbjct: 587  KEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL--DAKRESAFL 644

Query: 548  QDQVDELQSELEEYRAQGRVLR--LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSI 605
            + +  EL+ +++E     + +   + L  S  E  +     +E E      E   L   I
Sbjct: 645  RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLI 704

Query: 606  EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE----NE 661
            + ++          +D+ C  LELE K+   +K+L+      K+ +EN   R E    +E
Sbjct: 705  DGKV---------PKDLLC-NLELEGKITDLQKELN------KEVEENEALREEVILLSE 748

Query: 662  THTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE----------- 710
              +L  ++  L+ EI +   +  ++     +       ++ ++Q  LEE           
Sbjct: 749  LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATT 808

Query: 711  --------------EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT----- 751
                          +  H+  + + +  +E   R+ Q   +  +E +   SS        
Sbjct: 809  QSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL 868

Query: 752  -------EEKVRGLTQELEQFHQ--EQLTSLVEKHTLEKEELRKELL-EKHQRELQE--- 798
                   +EK R + + L +  Q  EQL +     TL+  E  K L+ EK Q+ L+E   
Sbjct: 869  SYKTQELQEKTREVQERLNEMEQLKEQLEN--RDSTLQTVEREKTLITEKLQQTLEEVKT 926

Query: 799  -GREKMETECNRRTSQIEA-QFQSDCQKVT-------ERCESALQSLEGRYRQELKDLQE 849
              +EK + +  + + QIE  Q +SD            E+  +AL+SL+ ++++ +  L+ 
Sbjct: 927  LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK-QHQETINTLKS 985

Query: 850  QQREEKSQWEFEKDELTQECAEAQELL-----KETLKREKTTSL--------VLTQEREM 896
            +  EE S+    ++   +   E Q+ +     K+ L+ + T +L        ++ Q+R++
Sbjct: 986  KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045

Query: 897  L-----EKTYKEHLNSMVVERQQLLQDL-EDLRNVSETQQS--LLSDQI---LELKSSHK 945
                  +   ++ L S++ E++QL  DL E++    E Q+   LL D++    E+ +  K
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105

Query: 946  RELREREEVLCQ-----AGASEQL--ASQRLERLE---MEHDQERQEMMSKLLAMENI-- 993
                ++E  L +     A   E+L   SQ+L+  +   +   +E  EM  K+  +EN+  
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165

Query: 994  ----HKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE------EE 1043
                 + T E  + ER E++ +++    ++K + +    L  LQ   +   +       E
Sbjct: 1166 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE 1225

Query: 1044 VEGDGALSLLQQGEQL------LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK 1097
            +E  G    LQ  E+L      L+E+ + +  L+R+  +   + +    ++ +   +LQ+
Sbjct: 1226 IEATG----LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN-TQDLEKSHTKLQE 1280

Query: 1098 LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGS 1157
              P L           E   N  E +E    Q    ++E +T +    D          S
Sbjct: 1281 EIPVL-------HEEQELLPNVKEVSE---TQETMNELELLTEQSTTKD----------S 1320

Query: 1158 TGTSSVQRQEV----KIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCAD 1213
            T  + ++ + +    K +ES+  ++  ++  ++ +T  E+ E+K+   QL+E +    A 
Sbjct: 1321 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH--DQLKEHIRETLAK 1378

Query: 1214 CDRASEKKQDLL---------------------FDVSVLKKKLKML---ERIPEASPKYK 1249
               +  K++  L                      D ++L+ +++ML   +R+ E+  + K
Sbjct: 1379 IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMK 1438

Query: 1250 LLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELK--------KMEEVT 1301
                 V++E D LQ    ++++  D+  EN KE+ A+    ++ELK        + E + 
Sbjct: 1439 ----SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETIN 1494

Query: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP-- 1359
            E  ++L +   E+    ++L  +  +LQ KI+++ E   Q     + E   +  E++   
Sbjct: 1495 ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK 1554

Query: 1360 -------------DGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLE-GNTQLLEKVK 1405
                         +  +L+L   L+E    ++ +    EE K+  + L+    QL E  K
Sbjct: 1555 EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK 1614

Query: 1406 AHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELT 1465
                       + +Q           E+   +   +++    +  +  +E E  +L ++ 
Sbjct: 1615 EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQIL 1674

Query: 1466 RKLKERVTILVKQKDVLSHGE-----KEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1520
             +  E +  + K++D L   E     + ++LK  + +      E Q++++++    ++ Q
Sbjct: 1675 HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQ 1734

Query: 1521 QENSILR-------NEITTLNEEDSISN--LKLGTLNGSQEEMWQKTETVKQENAAVQKM 1571
            +    LR       NEI+ + ++   SN  LK   L   QEE+      +K++    Q+ 
Sbjct: 1735 ETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLK-IQEELRIAHMHLKEQ----QET 1789

Query: 1572 VENLKKQISEL--KIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEML-CQKEKEPGNS 1628
            ++ L+  +SE   K+ N Q DLEN+     N++ QEK+QEL     +++  +K+      
Sbjct: 1790 IDKLRGIVSEKTDKLSNMQKDLENS-----NAKLQEKIQELKANEHQLITLKKDVNETQK 1844

Query: 1629 ALEEREQEKFNLKEE---LERCKVQSSTLVSSLEAELSEVKI------QTHIVQQENHLL 1679
             + E EQ K  +K++   L + ++++  L   L   L E+K           V++   L 
Sbjct: 1845 KVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLE 1904

Query: 1680 KDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHR 1739
            +D+L++  Q  +  DL + QQ+           LK    LS+E    VDKL +  + E  
Sbjct: 1905 RDQLKESLQETKARDL-EIQQE-----------LKTARMLSKEHKETVDKL-REKISEKT 1951

Query: 1740 IATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEAL 1799
            I            Q + ++  L  S++++Q     +Q   LQ+ R+K D+ ++ ++   +
Sbjct: 1952 I------------QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999

Query: 1800 KQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERL 1859
            +Q    L KQ +       A  ++     + N Q      K  H   EE +++ +E + L
Sbjct: 2000 EQ----LKKQFE-------AQNLSMQSVRMDNFQ----LTKKLHESLEEIRIVAKERDEL 2044

Query: 1860 QTMVQNTKAE----LTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQF 1915
            + + ++ K E    +   RE + +   N   K +K L   G  + TE    SL+ +C + 
Sbjct: 2045 RRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTE----SLREKCSRI 2100

Query: 1916 Q---KEQSPANRKVSQMNSLEQELE-TIHLENEGLKKKQVKLDEQLMEMQHLRSTAT 1968
            +   K  S  +     +N L  +LE  I  + E   + +  L    ++ +H+    T
Sbjct: 2101 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFT 2157



 Score =  164 bits (414), Expect = 1e-39
 Identities = 356/1708 (20%), Positives = 715/1708 (41%), Gaps = 300/1708 (17%)

Query: 347  ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDL--------DKAEKLKS 398
            +NE++  +  I   +L   K E++ +LE    V+ EKE+L++DL        +  E+L+ 
Sbjct: 1035 DNEIIEQQRKIF--SLIQEKNELQQMLE---SVIAEKEQLKTDLKENIEMTIENQEELR- 1088

Query: 399  LMASEVDDHHAAIERRNEYNLRKLDEEYK--ERIAALKNELRKEREQILQQAGKQRLELE 456
            L+  E+      + +   + ++K  E  +  +R+A ++ +L KE+ Q LQ+  +Q L ++
Sbjct: 1089 LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL-KEKSQQLQEKQQQLLNVQ 1147

Query: 457  QEIEKAKTEENYIRDRLALSLKENS----RLENELLENAEKLAE-YENLTNKLQRNLENV 511
            +E+ + + + N I + L   LK        +E E LE A+KL E YE + +  +      
Sbjct: 1148 EEMSEMQKKINEI-ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK 1206

Query: 512  LAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL-----QDQVDELQSELEEYRAQGR 566
              +K  + +      +++E   T ++ + E +   +     Q+ +DEL+  + E  AQ  
Sbjct: 1207 ELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ-- 1264

Query: 567  VLRLPLKNSPSEEVEANSGGIEPEHGL------GSEECNPLNMSIEAELVIEQMKEQHHR 620
            ++          +++     +  E  L       SE    +N   E EL+ EQ   +   
Sbjct: 1265 IINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMN---ELELLTEQSTTKDST 1321

Query: 621  DICCLRLELEDKVRHYEK--QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE 678
             +   R+E+E ++R  EK  +  E + S  K ++N+K   E     LE +   LK  I E
Sbjct: 1322 TLA--RIEME-RLRLNEKFQESQEEIKSLTKERDNLKTIKE----ALEVKHDQLKEHIRE 1374

Query: 679  LQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASF 738
               +    +    ++    E++ +  ++  E E+   ++   L+ E+E+     + Q S 
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434

Query: 739  EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKE---LLEKHQ-- 793
            +  +   +     +     L  E +Q  +E +  +V KH   +EEL+     L E+ +  
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQL-KENIKEIVAKHLETEEELKVAHCCLKEQEETI 1493

Query: 794  RELQEGREKMETECNRRTSQIEA---QFQSDCQKVTERCE-------------------- 830
             EL+    + ETE +    Q+EA   + Q+  Q++ E+ E                    
Sbjct: 1494 NELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQF 1553

Query: 831  --------SALQSLEGRYRQELKDLQEQQRE------EKSQW-------EFEKDELTQEC 869
                    SALQS+E +  +    LQE Q E      EK +        + E+D+L +  
Sbjct: 1554 KEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT 1613

Query: 870  AEAQELLKETLKRE----KTTSLVLTQER----EMLEK---TYKEHLNSMVVERQQLLQ- 917
             E    +KE+ ++E    K T++  TQE+    E L++   T K +L ++  E  +L Q 
Sbjct: 1614 KEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQI 1673

Query: 918  ---DLEDLRNVSETQQSLLS---------DQILE-LKSSHKRELREREEVLCQAGASEQL 964
               +LE++R+V++ +  L S         DQ+ E L+ +  R+L ++EE+        ++
Sbjct: 1674 LHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEEL--------KI 1725

Query: 965  ASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAE---MSTEISRLQSKIKE 1021
                L+  +   D+ R  +  K   + N+ K    + D  +A+   +  E+      +KE
Sbjct: 1726 VHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE 1785

Query: 1022 MQQATSPL-SMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080
             Q+    L  ++      +   + + + + + LQ+  Q L+ N   L++L++     V E
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKD----VNE 1841

Query: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGV 1138
              K  +E+ +L+++++  +  L +S    E       N A++    L++ ++  K+ + +
Sbjct: 1842 TQKKVSEMEQLKKQIK--DQSLTLSKLEIENL-----NLAQKLHENLEEMKSVMKERDNL 1894

Query: 1139 TRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKN 1198
             R      LE D++++           QE K  + E   E  +    S+E +    +L+ 
Sbjct: 1895 RRVEETLKLERDQLKE---------SLQETKARDLEIQQELKTARMLSKEHKETVDKLRE 1945

Query: 1199 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE 1258
            +IS+   Q+  +  D D++ ++ Q  + ++   KK+L++L    + +  +K + E    +
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQ--KKELQLLRVKEDVNMSHKKINEMEQLK 2003

Query: 1259 NDCLQEELRMMETRYD-----EALENNKELTAEVFRLQDELKKMEE-----------VTE 1302
                 + L M   R D     + L  + E    V + +DEL++++E              
Sbjct: 2004 KQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLR 2063

Query: 1303 TFLSLEKSYDEVKIENEELNV----LVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIE 1358
              ++ ++   +VK E   L+     L   L+ K  +++E + +  +       L  L ++
Sbjct: 2064 EMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLD 2123

Query: 1359 PDGNI-----LQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLH 1413
             +  I     L +       +P +++ H  IE+    NQ        + K   + ++++ 
Sbjct: 2124 LEKEIEFQKELSMRVKANLSLPYLQTKH--IEKLFTANQRCSMEFHRIMKKLKYVLSYVT 2181

Query: 1414 GTIQT-HQERPRVQNQVILE-ENTTLLGFQDKHFQHQATIAELELEKTKL--------QE 1463
               +  H+   + +   I E E    L  + +H Q    +   EL   KL        +E
Sbjct: 2182 KIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEE 2241

Query: 1464 LTRKLKERV--TILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1521
            + +   E    +I  + + VLS+    +E+   + +   T  ++++    ++ E++++ Q
Sbjct: 2242 ILKDFSESEFPSIKTEFQQVLSN---RKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ 2298

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI-S 1580
             N+   N I  +  E +    +  T++   +E  Q  +++K++N  + K  + LK  + S
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATIS---KEWEQDLKSLKEKNEKLFKNYQTLKTSLAS 2355

Query: 1581 ELKIKNQQLDLENTELSQKNSQ-NQEKLQELNQRLTE------------MLCQKEKE--- 1624
              ++     D +N  ++ + +Q   EK++EL   L E            +  QKE E   
Sbjct: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTN 2415

Query: 1625 -----------PGNSALEERE------QEKFNL-----KEELERCKVQSSTL-------V 1655
                         N  LE+ +      Q+K  L     KEE+E  K++   +        
Sbjct: 2416 DIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNA 2475

Query: 1656 SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL--------HRCPDLSD---------- 1697
               E E+S  K      ++   LL++ L + +Q         H  P  S+          
Sbjct: 2476 KEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSG 2535

Query: 1698 ----------------FQQKISSVLSYNEKLLKEK-------EALSEELNSCVDKLAKSS 1734
                             +++IS +   NE+L+K+K       + LS E+ +  ++  K  
Sbjct: 2536 IVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKRE 2595

Query: 1735 LLEHRIATMKQEQKSWE-HQSASLKSQLVASQEKVQNLEDTVQNVNLQM----SRMKSDL 1789
               H+  T +   KS +   +AS K Q+  SQ K +NL+D V   + +     SR KS  
Sbjct: 2596 --AHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKS-- 2651

Query: 1790 RVTQQEKEALKQEVMSLHKQLQNAGGKS 1817
              +           + L  ++QNAG +S
Sbjct: 2652 LPSPHPVRYFDNSSLGLCPEVQNAGAES 2679



 Score =  134 bits (337), Expect = 9e-31
 Identities = 298/1488 (20%), Positives = 615/1488 (41%), Gaps = 207/1488 (13%)

Query: 264  LKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQ 323
            LK H   ++ DE  R  +  +A       ++ +  D    H  ++  +    EE     Q
Sbjct: 1244 LKEH--QETIDELRRSVSEKTA-------QIINTQDLEKSHTKLQEEIPVLHEE-----Q 1289

Query: 324  EILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREK 383
            E+L  +    +    + EL L  E     TK+S     LA  + E   L E+  +   E 
Sbjct: 1290 ELLPNVKEVSETQETMNELELLTEQS--TTKDS---TTLARIEMERLRLNEKFQESQEEI 1344

Query: 384  EKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQ 443
            + L  + D  + +K  +  + D               +L E  +E +A ++    K+ + 
Sbjct: 1345 KSLTKERDNLKTIKEALEVKHD---------------QLKEHIRETLAKIQESQSKQEQS 1389

Query: 444  I-LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTN 502
            + +++   +  ++  E+E+ K +++ +  R+ + +   S+   E  +  + +A+ ++   
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALL-RIEIEMLGLSKRLQESHDEMKSVAKEKDDLQ 1448

Query: 503  KLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR---NEYERQCRVLQDQVDELQSELE 559
            +LQ  L++   +   ++    A+    EE L        E E     L+  + E ++E+ 
Sbjct: 1449 RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS 1508

Query: 560  EYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHH 619
              + Q   +   L+N   E  E              E+ N   +S   E V E  + + H
Sbjct: 1509 TIQKQLEAINDKLQNKIQEIYEKE------------EQFNIKQISEVQEKVNELKQFKEH 1556

Query: 620  RDICCLRLE-LEDKVRHYEKQLDETVVSCK---KAQENMKQRHENETHTLEKQISDLKNE 675
            R      L+ +E K+     +L E+    +   K +E MK+  E     L+ +   LK  
Sbjct: 1557 RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE----ALQIERDQLKEN 1612

Query: 676  IAELQGQAAVLKEAHHE---ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLT 732
              E+  +    +E  ++    T  +E ++K  +++  +E+   Q KL L++      RLT
Sbjct: 1613 TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ-KLNLENIETENIRLT 1671

Query: 733  QA-------QASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELR 785
            Q          S  +ER+ L+S    EE ++    +L++  +E +T  +EK    +EEL+
Sbjct: 1672 QILHENLEEMRSVTKERDDLRS---VEETLKVERDQLKENLRETITRDLEK----QEELK 1724

Query: 786  KELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELK 845
              ++  H +E QE  +K+    + +T++I     S+ QK  E    AL++ + + ++EL+
Sbjct: 1725 --IVHMHLKEHQETIDKLRGIVSEKTNEI-----SNMQKDLEHSNDALKAQDLKIQEELR 1777

Query: 846  ----DLQEQQR----------EEKSQWEFEKDELTQECAEAQELLKE---------TLKR 882
                 L+EQQ           E+  +    + +L    A+ QE ++E         TLK+
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK 1837

Query: 883  EKTTSLVLTQEREMLEKTYKEH---LNSMVVER----QQLLQDLEDLRNVSETQQSLLSD 935
            +   +     E E L+K  K+    L+ + +E     Q+L ++LE++++V + +     D
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER-----D 1892

Query: 936  QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM---EH----DQERQEMMSKLL 988
             +  ++ + K E  + +E L +  A +    Q L+   M   EH    D+ R+++  K +
Sbjct: 1893 NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952

Query: 989  AMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSML------------QSGC 1036
             + +I K      D+ + E+  +I  LQ K  ++ +    ++M             Q   
Sbjct: 1953 QISDIQK----DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEA 2008

Query: 1037 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATE--ISRLQQR 1094
            Q +  + V  D    L ++  + LEE    +++ +R   + +KE++KM  +  I+ L++ 
Sbjct: 2009 QNLSMQSVRMDN-FQLTKKLHESLEEIR--IVAKERDELRRIKESLKMERDQFIATLREM 2065

Query: 1095 LQK------LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE 1148
            + +      ++P   + S   +  TE       + +  L++             +  DLE
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE 2125

Query: 1149 DD-------EVRDLGSTGTSSVQRQEVK---IEESEASVEGFSELENSEETRTESWELKN 1198
             +        +R   +     +Q + ++         S+E    ++  +   +   ++K 
Sbjct: 2126 KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185

Query: 1199 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIP---EASPKYKLLYEDV 1255
            +  +   +  M   D     EK+++LL  +  L++   +  R     + +    L  E++
Sbjct: 2186 EQHESINKFEMDFID---EVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242

Query: 1256 SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVK 1315
             +  D  + E   ++T + + L N KE+T     L++ L    ++ +    ++K  D + 
Sbjct: 2243 LK--DFSESEFPSIKTEFQQVLSNRKEMTQF---LEEWLNTRFDIEKLKNGIQKENDRIC 2297

Query: 1316 IENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVP 1375
              N   N  ++ +  +  + +E          WE  L++L+ E +  + +  QTL+  + 
Sbjct: 2298 QVNNFFNNRIIAIMNESTEFEERSATISK--EWEQDLKSLK-EKNEKLFKNYQTLKTSLA 2354

Query: 1376 RVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQT--HQERPRVQNQVILEE 1433
                V+   ++ K  +          EK++  E + LH   ++  H+E   ++ Q  LE 
Sbjct: 2355 SGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENS-LHEAKESAMHKESKIIKMQKELEV 2413

Query: 1434 NTTLLGFQDKHFQHQATIAELE--LEKTK--LQELTRKL-------KERVTILVKQKDVL 1482
               ++       + QA + E    LEKTK  +Q L  K+       KE +  L K K V 
Sbjct: 2414 TNDIIA------KLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL-KMKLVK 2466

Query: 1483 SHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1542
               EK +  K    ++  T + ++ + E++R   E L++        + + + +   SN 
Sbjct: 2467 IDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNK 2526

Query: 1543 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1602
             L    GS      K   +K E+         L+K+IS+LK +N+QL  +  EL   N  
Sbjct: 2527 PLTCGGGSGIVQNTKALILKSEHI-------RLEKEISKLKQQNEQLIKQKNELLSNNQH 2579

Query: 1603 NQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL--ERCK 1648
               +++   +R  +    K+    NS    +     + K+++   +CK
Sbjct: 2580 LSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCK 2627



 Score =  134 bits (336), Expect = 1e-30
 Identities = 285/1352 (21%), Positives = 562/1352 (41%), Gaps = 221/1352 (16%)

Query: 834  QSLEGRYRQELKDLQEQQRE---EKSQWEFEKDELTQECAEAQELLK-ETLKREKTTSLV 889
            ++L  RYR+E+ DL++Q  E   E      EKD+L Q   E   L K +  K E  T ++
Sbjct: 342  EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401

Query: 890  LTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE-- 947
            +T     L++  K      V      L  +  ++N +   Q  +   I     +HK    
Sbjct: 402  VTSSSLTLQQELKAKRKRRVT---WCLGKINKMKNSNYADQFNIPTNI--TTKTHKLSIN 456

Query: 948  -LREREEVLCQAGASEQLASQRLERL-EMEHDQERQEMMSKLLAMENIH------KATCE 999
             LRE +E +C   +   + S  L+ L E+E +       +KLL  ENI       +A  +
Sbjct: 457  LLREIDESVC---SESDVFSNTLDTLSEIEWNP-----ATKLLNQENIESELNSLRADYD 508

Query: 1000 TADRERAEMSTEISRLQSKIKEMQ-----QATSPLSMLQSGCQVIGE----------EEV 1044
                +  ++ TE   ++ K+KE       +A    +      Q+I E           EV
Sbjct: 509  NLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEV 568

Query: 1045 EGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEIS--------RLQQRL- 1095
                  + L    +LL E  D +  LQ   +    EN+KM    S        +++Q L 
Sbjct: 569  YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLF 628

Query: 1096 --------QKLEPGLVMSSCLD-EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSD 1146
                     K E   + S  L+ +   +    T +Q E  +Q  ++ Q+E   +  V  D
Sbjct: 629  DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS-QLEAKKKMQV--D 685

Query: 1147 LEDD------EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200
            LE +      E+  L S     V +  +   E E  +    +  N E    E+  L+ ++
Sbjct: 686  LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA--LREEV 743

Query: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVL-KKKLKMLERIPEASPKYKLLYEDVSREN 1259
              L E L  L ++ +R  ++ QD   ++ ++  +K K+   +     + + L E++ +  
Sbjct: 744  ILLSE-LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK 802

Query: 1260 DCLQ----------------EELRM-METRYDEALENNKELTAEVFRLQDELKKMEEVTE 1302
            D L                 + L M  E +Y   LE N+ +  E+  L  E +K +    
Sbjct: 803  DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS--- 859

Query: 1303 TFLSLEKSYDEVKIENEELNVLVLRLQ---GKIEKLQESVVQRCDCCLWEASLENLEIEP 1359
               SL     E+  + +EL      +Q    ++E+L+E +  R      +++L+ +E E 
Sbjct: 860  ---SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR------DSTLQTVEREK 910

Query: 1360 DGNILQLNQTLEECVPRVRSVHHVIEECKQ-------------------ENQYLEGNTQL 1400
                 +L QTLEE    V+++    ++ KQ                    N  ++   QL
Sbjct: 911  TLITEKLQQTLEE----VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQL 966

Query: 1401 ---LEKVKAHEIAWLHGTIQTHQER--PRVQNQVILEENTTLLGFQDKHFQHQ--ATIAE 1453
               LE +K H+      TI T + +    V   + +EENT   G     FQ +      +
Sbjct: 967  RNALESLKQHQ-----ETINTLKSKISEEVSRNLHMEENT---GETKDEFQQKMVGIDKK 1018

Query: 1454 LELEKTKLQELTRKLKE--------RVTILVKQKDVLSH------GEKEEELKAMMHDLQ 1499
             +LE    Q LT  +K+        ++  L+++K+ L         EKE+    +  +++
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078

Query: 1500 ITCSEMQQKVELLRYESEK-----LQQENSILRNEITTLNEEDSISNL--KLGTLNGSQE 1552
            +T  E Q+++ LL  E +K      Q++N  ++ E       D ++ +  KL   +   +
Sbjct: 1079 MTI-ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137

Query: 1553 EMWQKTETVKQENAAVQKM---VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQE 1609
            E  Q+   V++E + +QK    +ENLK ++   ++  + ++ E  EL+QK ++N E+++ 
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKS 1197

Query: 1610 LNQ-----RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV---QSSTLVSSLEAE 1661
            + +     +  +   + E++     + E E      KEEL+   +   +    +  L   
Sbjct: 1198 ITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS 1257

Query: 1662 LSEVK---IQTHIVQQENHLLKDEL----EKMKQLHRCPDLSDFQQKISSVLSYNEKLLK 1714
            +SE     I T  +++ +  L++E+    E+ + L    ++S+ Q+ ++ +     +LL 
Sbjct: 1258 VSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNEL-----ELLT 1312

Query: 1715 EKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDT 1774
            E+    +       ++ +  L E +    ++E KS   +  +LK+   A + K   L++ 
Sbjct: 1313 EQSTTKDSTTLARIEMERLRLNE-KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH 1371

Query: 1775 VQN--VNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEI-----ATHPS 1827
            ++     +Q S+ K +  +  +EK+    +++S  +Q +         EI     +    
Sbjct: 1372 IRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQ 1431

Query: 1828 GLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1887
              H++ K ++ +K D  +   Q++L  E+++L+  ++   A+   + E+++     L  K
Sbjct: 1432 ESHDEMKSVAKEKDD--LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL--K 1487

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK 1947
             Q+       +N +E+E      E    QK+    N K      L+ +++ I+ + E   
Sbjct: 1488 EQEETINELRVNLSEKE-----TEISTIQKQLEAINDK------LQNKIQEIYEKEEQFN 1536

Query: 1948 KKQV-KLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLL---- 2002
             KQ+ ++ E++ E++  +       S     LQ ++ +   +  R Q  Q + Q++    
Sbjct: 1537 IKQISEVQEKVNELKQFKEHRKAKDSA----LQSIESKMLELTNRLQESQEEIQIMIKEK 1592

Query: 2003 -QAERINQHLQEELENRTSETNTPQALLPEQR 2033
             + +R+ + LQ E +     T    A + E +
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 142/691 (20%), Positives = 284/691 (41%), Gaps = 109/691 (15%)

Query: 1430 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1489
            +LEE   L   Q++  ++   +       T  QEL  K K RVT  + + + + +    +
Sbjct: 379  LLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYAD 438

Query: 1490 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-------------- 1535
            +     +   IT    +  + LLR   E +  E+ +  N + TL+E              
Sbjct: 439  QFNIPTN---ITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQEN 495

Query: 1536 -EDSISNLKLG---------TLNGSQEEMWQKTE--------------TVKQENAAVQKM 1571
             E  +++L+            L   +EEM  K +              T K +   +   
Sbjct: 496  IESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHE 555

Query: 1572 VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE 1631
            + NLK  +   ++ NQ  DLEN ELS K    +EK  ++ ++L E +        +  LE
Sbjct: 556  ISNLKNLVKHAEVYNQ--DLEN-ELSSKVELLREKEDQI-KKLQEYI-------DSQKLE 604

Query: 1632 EREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKM----K 1687
              + +     E +E  K    TL  + E    + K ++  ++ EN  LK++++++    K
Sbjct: 605  NIKMDLSYSLESIEDPKQMKQTLFDA-ETVALDAKRESAFLRSENLELKEKMKELATTYK 663

Query: 1688 QLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEE---LNSCVD-KLAKSSL----LEHR 1739
            Q+    D+  +Q ++ +       L KE ++   E   L S +D K+ K  L    LE +
Sbjct: 664  QMEN--DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK 721

Query: 1740 IATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEAL 1799
            I  +++E      ++ +L+ +++   E +++L   V+ +  ++     +L +   EK+ L
Sbjct: 722  ITDLQKELNKEVEENEALREEVILLSE-LKSLPSEVERLRKEIQDKSEELHIITSEKDKL 780

Query: 1800 KQEVMSLHKQLQNAG-----GKSWAPEIATHPSGLHNQQKRLSWDKLDHL-MNEEQQLLW 1853
              EV  +HK+ +  G     GK+   ++AT  S   +  +     K  H+   ++ +++ 
Sbjct: 781  FSEV--VHKESRVQGLLEEIGKT-KDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVL 837

Query: 1854 QENERLQTMVQN--------------TKAELTHS----REKVRQLESNLLPKHQ---KHL 1892
            +ENER+   + N               K EL++     +EK R+++  L    Q   +  
Sbjct: 838  EENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE 897

Query: 1893 NPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1952
            N   T+   E+EK  +  +  Q  +E         + + L+Q  E++ +E + LK     
Sbjct: 898  NRDSTLQTVEREKTLITEKLQQTLEE---VKTLTQEKDDLKQLQESLQIERDQLKSDIHD 954

Query: 1953 LDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ----RQLLQAERIN 2008
                 ++ Q     A  S   H   +  L+ +    V R   ++      +   Q + + 
Sbjct: 955  TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVG 1014

Query: 2009 QHLQEELENRTSETNTPQA----LLPEQRAV 2035
               +++LE + ++T T       ++ +QR +
Sbjct: 1015 IDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 90/477 (18%), Positives = 184/477 (38%), Gaps = 55/477 (11%)

Query: 1544 LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQN 1603
            L  L  +    + K      E +  + +++  +K+I +LK + +++ LE    + +  Q 
Sbjct: 317  LTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQL 376

Query: 1604 QEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELS 1663
             + L+E                    L++ + EK    E L R  V SS+L    E +  
Sbjct: 377  AQLLEE-----------------KDLLQKVQNEKI---ENLTRMLVTSSSLTLQQELKAK 416

Query: 1664 EVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL 1723
              +  T  + + N +          +         +  I+ +   +E +  E +  S  L
Sbjct: 417  RKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTL 476

Query: 1724 NSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS 1783
            ++        S +E   AT    Q++ E +  SL++         + L    + + L++ 
Sbjct: 477  DTL-------SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL- 528

Query: 1784 RMKSDL-RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLD 1842
            + K+DL      E++  K + M L  ++ N   K+       +   L N+       K++
Sbjct: 529  KEKNDLDEFEALERKTKKDQEMQLIHEISNL--KNLVKHAEVYNQDLENELS----SKVE 582

Query: 1843 HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTE 1902
             L  +E Q+   +       ++N K +L++S E +        PK  K      T+   E
Sbjct: 583  LLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIED------PKQMKQ-----TLFDAE 631

Query: 1903 QEKLSLKRECDQFQKEQSPANRKVSQM----NSLEQELETIHLENEGLKKKQVKLDEQLM 1958
               L  KRE    + E      K+ ++      +E +++    + E  KK QV L+++L 
Sbjct: 632  TVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQ 691

Query: 1959 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEEL 2015
               +  +  T        D ++ +   C +    +   LQ++L +    N+ L+EE+
Sbjct: 692  SAFNEITKLT-----SLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV 743


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1063 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1121 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1174

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1235 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1286

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1329

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1330 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1378

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1439 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1556

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1675

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1734

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1839

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1840 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2373

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2427

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1402

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1458

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1517

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2116

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2175

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2176 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2220

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2279

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2280 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2330

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2331 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2377

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2378 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2432

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2489

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2600

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2661 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2709



 Score =  172 bits (437), Expect = 2e-42
 Identities = 349/1690 (20%), Positives = 674/1690 (39%), Gaps = 264/1690 (15%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 970  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1028

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1089 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1149 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1385 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1503 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1556

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1853

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1910

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1971 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2028

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH- 1843
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444

Query: 1844 ----------------LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1887
                             + +E +LL  ++E +QT+ Q    + T + ++    E + L +
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKREC-DQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
             ++ +         EQEK  L++   D+  K Q     +  Q   +EQE + +    E  
Sbjct: 2505 RERFI---------EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555

Query: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
            +++Q + +E +   Q               +LQ L+QQ      R Q    Q +LL  E 
Sbjct: 2556 RRRQHEAEEGVRRKQE--------------ELQQLEQQ------RRQ----QEELLAEE- 2590

Query: 2007 INQHLQEELE 2016
             NQ L+E+L+
Sbjct: 2591 -NQRLREQLQ 2599



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1953 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2066

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2118

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2172

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2173 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2216

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2275

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2334

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2335 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2451 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2491

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2492 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2549

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2550 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2581

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2582 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2630

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2631 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2686 EDVR 2689



 Score =  106 bits (265), Expect = 2e-22
 Identities = 283/1380 (20%), Positives = 541/1380 (39%), Gaps = 197/1380 (14%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 968  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1081

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1142 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1184

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1185 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1354

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1412

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1413 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1463

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1698

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1815

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1816 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1923

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1924 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2037

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2214

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2016
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2215 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2271



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 336/1836 (18%), Positives = 694/1836 (37%), Gaps = 231/1836 (12%)

Query: 339  LTELTLALENELLVTKNSIHQAALASFKAEIRHLLE-RVDQVVREKEKLRSDLDKAEKLK 397
            L  +   L+ E  + +  ++QA  A  ++++R L   +V Q   E E+   DLDKA+ + 
Sbjct: 394  LQRIVTKLQMEAGLCEEQLNQAD-ALLQSDVRLLAAGKVPQRAGEVER---DLDKADSMI 449

Query: 398  SLMASEV----DDHHAAIER--RNEYNLRK----LDEEYKERIAALKNELRKEREQILQQ 447
             L+ ++V    D  H   E+  R  Y L +    +  EY  R+ A       +  Q+  Q
Sbjct: 450  RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 509

Query: 448  AGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN-----ELLENAEKLAEYENLTN 502
            + ++R ELE    +      Y++D LA   +   R++      +L     +L  +  L  
Sbjct: 510  SVQRRPELEDSTLR------YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 563

Query: 503  KLQR---NLENVLAEKFGDLDPSSAEFF--------LQEERLTQMRNEYERQCRVLQDQV 551
             ++     +E   +++ G L P++   +        LQ  +L        R    L   V
Sbjct: 564  SIEEFRAKIERARSDE-GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 622

Query: 552  DELQSEL--------EEY------RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE- 596
                 EL        EE       R      +    ++   E+E     I+     G   
Sbjct: 623  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 682

Query: 597  --ECNPLNMSIEA-ELVIEQMKEQHHRDICCLRLELEDKVRHYE--KQLDETVVSCKKAQ 651
              E +P   ++E+ +  ++       +  CC+   L++   +++    + E     +K Q
Sbjct: 683  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 742

Query: 652  ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEE 711
            E +++++  +      ++ DL   + + Q +   L E     +   +  K  +Q+K    
Sbjct: 743  EALRRKYSCDRSATVTRLEDL---LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799

Query: 712  KTHLQEKLRLQHEMELKARLTQAQASFEREREG-LQSSAWTEEKVRGLTQELEQFHQEQL 770
               ++ +L L    + K          E +  G  Q S W     + L+    +     +
Sbjct: 800  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW-----KVLSSSGSEAAVPSV 854

Query: 771  TSLVEKHTLEKEELRKELLEKHQRELQ-------EGREKMETECNRRTSQIEAQFQSDCQ 823
              LV     E +E    L  +HQ  +        + +  +  +  RR  Q+   +     
Sbjct: 855  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 914

Query: 824  KVT--ERCESALQSLEGRYRQELKDLQEQQR---EEKSQWEFEKDELTQECAEAQELLKE 878
            +    E    AL SLE  Y+  L+D Q+      E++   E E    +    +  + L++
Sbjct: 915  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 974

Query: 879  TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE--TQQSLLSDQ 936
              + E      +++ +++  +   E   +  V R +L  D E  R  ++   +Q     +
Sbjct: 975  GAQEESRCQRCISELKDI--RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1032

Query: 937  ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA 996
            +  L     R   E E+VL     S    + R E LE+   +  Q      + +E +   
Sbjct: 1033 VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE-LELTLGKLEQVRSLSAIYLEKLKTI 1091

Query: 997  TCETADRERAEMSTEISRL-QSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQ 1055
            +      + AE   E+ R  + ++KE Q   + L  L++    + +   + +        
Sbjct: 1092 SLVIRGTQGAE---EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148

Query: 1056 GEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-LEPGLVMSSCLDEPATE 1114
                L    +V   LQ+ H +   E  +    +++L +R Q  L    V    L++   +
Sbjct: 1149 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1208

Query: 1115 --FFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEE 1172
              ++  +A+    +LQ  R +Q +        S    +++R   +     ++R   K+EE
Sbjct: 1209 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL-LEEIERHGEKVEE 1267

Query: 1173 SEASVEGF---------------SELE-------------NSEETRTESWELKNQISQLQ 1204
             +   + +               ++LE              SE    E  +L+   S+L 
Sbjct: 1268 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1327

Query: 1205 ---EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
                Q +   ++  R  E+++ L       +++   L  +  A  K + L E  ++    
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAEVEAALEKQRQLAEAHAQAKAQ 1385

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFR----LQDELKKMEEVTETFLSLEKSYDE---- 1313
             + E + ++ R  E +   +E   +  +    +Q+EL+++ + +E  +  +    E    
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445

Query: 1314 --VKIENEELNVLVLRLQ----------GKIEKL----QESVVQRCDCCLWEASLENLEI 1357
              ++IE EE+ V+ L+L+          G+++ L    +E+  Q+      +   E L  
Sbjct: 1446 SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA---QEEAERLRR 1501

Query: 1358 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTI 1416
            +      +  Q   E   RV++      E ++  Q LE    Q  E  +    A +    
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561

Query: 1417 QTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILV 1476
            Q        Q     E  +    F +K  Q + ++ E  +   +L+E   +  ++     
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1621

Query: 1477 KQKDVLSHGEKEEELKAMMH-DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
            + ++      +  +LKA     L++   E+ Q+  L + E+EK Q+E +          E
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAE 1680

Query: 1536 EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE 1595
            E ++   +L       E+  Q  E   Q+  A ++ +  L+ +  + + + Q L+ E   
Sbjct: 1681 EQAVRQRELA--EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738

Query: 1596 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTL- 1654
            L ++ +   +K QEL   L ++  + E    + A  E E    + K + +R + ++    
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK-QRLEAEAGRFR 1797

Query: 1655 -----VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSV---- 1705
                  + L A   E K Q  + +++    + E E++             +K++++    
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV-----------LAEKLAAIGEAT 1846

Query: 1706 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1763
               +  E  LKEKEA +E L     +LA+    + R           E Q+A  K+ +  
Sbjct: 1847 RLKTEAEIALKEKEAENERLR----RLAEDEAFQRR---------RLEEQAAQHKADIEE 1893

Query: 1764 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIA 1823
               +++   D+      ++ R K  +  T +++  +++E+++L    + A       E+ 
Sbjct: 1894 RLAQLRKASDS------ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947

Query: 1824 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN 1883
                  + +    S ++ +     ++QL  +E  R +   +  +  L    E  RQ ++ 
Sbjct: 1948 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007

Query: 1884 LLP--------KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
            L          +  + L          Q +L+ +    + Q E+      V Q    EQE
Sbjct: 2008 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK---EQE 2064

Query: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 1995
            L+      + L+++Q  LD+   E +  R  A  +            ++A     RE   
Sbjct: 2065 LQ------QTLQQEQSVLDQLRGEAEAARRAAEEA------------EEARVQAEREA-A 2105

Query: 1996 QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
            Q +RQ+ +AER+ Q  +E+ + R       + L  E
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1067 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1124

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1125 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1178

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1179 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1239 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1290

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1291 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1333

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1334 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1382

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1383 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1442

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1443 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1501

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1502 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1560

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1679

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1738

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1843

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1844 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2080

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2140

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2201 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2260

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2377

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2431

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2492 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2545

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2546 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1406

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1462

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1521

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1581

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1582 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1641

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1702 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1761

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1881

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1882 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2120

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2179

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2180 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2224

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2225 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2283

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2284 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2334

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2335 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2381

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2382 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2436

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2493

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2604

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2605 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2664

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2665 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2713



 Score =  172 bits (437), Expect = 2e-42
 Identities = 349/1690 (20%), Positives = 674/1690 (39%), Gaps = 264/1690 (15%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 974  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1032

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1033 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1092

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1093 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1152

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1153 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1269 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1328

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1329 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1388

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1389 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1507 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1560

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1740

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1741 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1800

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1801 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1857

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1914

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1975 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2032

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH- 1843
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448

Query: 1844 ----------------LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1887
                             + +E +LL  ++E +QT+ Q    + T + ++    E + L +
Sbjct: 2449 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKREC-DQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
             ++ +         EQEK  L++   D+  K Q     +  Q   +EQE + +    E  
Sbjct: 2509 RERFI---------EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559

Query: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
            +++Q + +E +   Q               +LQ L+QQ      R Q    Q +LL  E 
Sbjct: 2560 RRRQHEAEEGVRRKQE--------------ELQQLEQQ------RRQ----QEELLAEE- 2594

Query: 2007 INQHLQEELE 2016
             NQ L+E+L+
Sbjct: 2595 -NQRLREQLQ 2603



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1897 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1956

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1957 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2070

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2122

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2176

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2177 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2220

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2279

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2280 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2338

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2339 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2455 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2495

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2496 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2553

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2554 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2585

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2586 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2634

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2635 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2689

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2690 EDVR 2693



 Score =  106 bits (265), Expect = 2e-22
 Identities = 283/1380 (20%), Positives = 541/1380 (39%), Gaps = 197/1380 (14%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 972  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1029

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1030 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1085

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1086 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1145

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1146 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1188

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1189 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1358

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1359 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1416

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1417 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1467

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1468 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1527

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1587

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1647

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1702

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1819

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1820 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1927

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1928 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1985

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1986 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2041

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2218

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2016
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2219 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2275



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 336/1836 (18%), Positives = 694/1836 (37%), Gaps = 231/1836 (12%)

Query: 339  LTELTLALENELLVTKNSIHQAALASFKAEIRHLLE-RVDQVVREKEKLRSDLDKAEKLK 397
            L  +   L+ E  + +  ++QA  A  ++++R L   +V Q   E E+   DLDKA+ + 
Sbjct: 398  LQRIVTKLQMEAGLCEEQLNQAD-ALLQSDVRLLAAGKVPQRAGEVER---DLDKADSMI 453

Query: 398  SLMASEV----DDHHAAIER--RNEYNLRK----LDEEYKERIAALKNELRKEREQILQQ 447
             L+ ++V    D  H   E+  R  Y L +    +  EY  R+ A       +  Q+  Q
Sbjct: 454  RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 513

Query: 448  AGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN-----ELLENAEKLAEYENLTN 502
            + ++R ELE    +      Y++D LA   +   R++      +L     +L  +  L  
Sbjct: 514  SVQRRPELEDSTLR------YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 567

Query: 503  KLQR---NLENVLAEKFGDLDPSSAEFF--------LQEERLTQMRNEYERQCRVLQDQV 551
             ++     +E   +++ G L P++   +        LQ  +L        R    L   V
Sbjct: 568  SIEEFRAKIERARSDE-GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 626

Query: 552  DELQSEL--------EEY------RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE- 596
                 EL        EE       R      +    ++   E+E     I+     G   
Sbjct: 627  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 686

Query: 597  --ECNPLNMSIEA-ELVIEQMKEQHHRDICCLRLELEDKVRHYE--KQLDETVVSCKKAQ 651
              E +P   ++E+ +  ++       +  CC+   L++   +++    + E     +K Q
Sbjct: 687  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 746

Query: 652  ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEE 711
            E +++++  +      ++ DL   + + Q +   L E     +   +  K  +Q+K    
Sbjct: 747  EALRRKYSCDRSATVTRLEDL---LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 803

Query: 712  KTHLQEKLRLQHEMELKARLTQAQASFEREREG-LQSSAWTEEKVRGLTQELEQFHQEQL 770
               ++ +L L    + K          E +  G  Q S W     + L+    +     +
Sbjct: 804  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW-----KVLSSSGSEAAVPSV 858

Query: 771  TSLVEKHTLEKEELRKELLEKHQRELQ-------EGREKMETECNRRTSQIEAQFQSDCQ 823
              LV     E +E    L  +HQ  +        + +  +  +  RR  Q+   +     
Sbjct: 859  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 918

Query: 824  KVT--ERCESALQSLEGRYRQELKDLQEQQR---EEKSQWEFEKDELTQECAEAQELLKE 878
            +    E    AL SLE  Y+  L+D Q+      E++   E E    +    +  + L++
Sbjct: 919  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 978

Query: 879  TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE--TQQSLLSDQ 936
              + E      +++ +++  +   E   +  V R +L  D E  R  ++   +Q     +
Sbjct: 979  GAQEESRCQRCISELKDI--RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1036

Query: 937  ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA 996
            +  L     R   E E+VL     S    + R E LE+   +  Q      + +E +   
Sbjct: 1037 VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE-LELTLGKLEQVRSLSAIYLEKLKTI 1095

Query: 997  TCETADRERAEMSTEISRL-QSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQ 1055
            +      + AE   E+ R  + ++KE Q   + L  L++    + +   + +        
Sbjct: 1096 SLVIRGTQGAE---EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1152

Query: 1056 GEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-LEPGLVMSSCLDEPATE 1114
                L    +V   LQ+ H +   E  +    +++L +R Q  L    V    L++   +
Sbjct: 1153 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1212

Query: 1115 --FFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEE 1172
              ++  +A+    +LQ  R +Q +        S    +++R   +     ++R   K+EE
Sbjct: 1213 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL-LEEIERHGEKVEE 1271

Query: 1173 SEASVEGF---------------SELE-------------NSEETRTESWELKNQISQLQ 1204
             +   + +               ++LE              SE    E  +L+   S+L 
Sbjct: 1272 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1331

Query: 1205 ---EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
                Q +   ++  R  E+++ L       +++   L  +  A  K + L E  ++    
Sbjct: 1332 TLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAEVEAALEKQRQLAEAHAQAKAQ 1389

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFR----LQDELKKMEEVTETFLSLEKSYDE---- 1313
             + E + ++ R  E +   +E   +  +    +Q+EL+++ + +E  +  +    E    
Sbjct: 1390 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449

Query: 1314 --VKIENEELNVLVLRLQ----------GKIEKL----QESVVQRCDCCLWEASLENLEI 1357
              ++IE EE+ V+ L+L+          G+++ L    +E+  Q+      +   E L  
Sbjct: 1450 SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA---QEEAERLRR 1505

Query: 1358 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTI 1416
            +      +  Q   E   RV++      E ++  Q LE    Q  E  +    A +    
Sbjct: 1506 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1565

Query: 1417 QTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILV 1476
            Q        Q     E  +    F +K  Q + ++ E  +   +L+E   +  ++     
Sbjct: 1566 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1625

Query: 1477 KQKDVLSHGEKEEELKAMMH-DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
            + ++      +  +LKA     L++   E+ Q+  L + E+EK Q+E +          E
Sbjct: 1626 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAE 1684

Query: 1536 EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE 1595
            E ++   +L       E+  Q  E   Q+  A ++ +  L+ +  + + + Q L+ E   
Sbjct: 1685 EQAVRQRELA--EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1742

Query: 1596 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTL- 1654
            L ++ +   +K QEL   L ++  + E    + A  E E    + K + +R + ++    
Sbjct: 1743 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK-QRLEAEAGRFR 1801

Query: 1655 -----VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSV---- 1705
                  + L A   E K Q  + +++    + E E++             +K++++    
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV-----------LAEKLAAIGEAT 1850

Query: 1706 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1763
               +  E  LKEKEA +E L     +LA+    + R           E Q+A  K+ +  
Sbjct: 1851 RLKTEAEIALKEKEAENERLR----RLAEDEAFQRR---------RLEEQAAQHKADIEE 1897

Query: 1764 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIA 1823
               +++   D+      ++ R K  +  T +++  +++E+++L    + A       E+ 
Sbjct: 1898 RLAQLRKASDS------ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1951

Query: 1824 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN 1883
                  + +    S ++ +     ++QL  +E  R +   +  +  L    E  RQ ++ 
Sbjct: 1952 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2011

Query: 1884 LLP--------KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
            L          +  + L          Q +L+ +    + Q E+      V Q    EQE
Sbjct: 2012 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK---EQE 2068

Query: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 1995
            L+      + L+++Q  LD+   E +  R  A  +            ++A     RE   
Sbjct: 2069 LQ------QTLQQEQSVLDQLRGEAEAARRAAEEA------------EEARVQAEREA-A 2109

Query: 1996 QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
            Q +RQ+ +AER+ Q  +E+ + R       + L  E
Sbjct: 2110 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1063 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1121 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1174

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1235 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1286

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1329

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1330 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1378

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1439 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1556

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1675

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1734

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1839

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1840 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2373

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2427

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1402

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1458

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1517

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2116

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2175

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2176 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2220

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2279

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2280 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2330

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2331 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2377

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2378 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2432

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2489

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2600

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2661 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2709



 Score =  172 bits (437), Expect = 2e-42
 Identities = 349/1690 (20%), Positives = 674/1690 (39%), Gaps = 264/1690 (15%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 970  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1028

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1089 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1149 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1385 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1503 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1556

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1853

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1910

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1971 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2028

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH- 1843
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444

Query: 1844 ----------------LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1887
                             + +E +LL  ++E +QT+ Q    + T + ++    E + L +
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKREC-DQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
             ++ +         EQEK  L++   D+  K Q     +  Q   +EQE + +    E  
Sbjct: 2505 RERFI---------EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555

Query: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
            +++Q + +E +   Q               +LQ L+QQ      R Q    Q +LL  E 
Sbjct: 2556 RRRQHEAEEGVRRKQE--------------ELQQLEQQ------RRQ----QEELLAEE- 2590

Query: 2007 INQHLQEELE 2016
             NQ L+E+L+
Sbjct: 2591 -NQRLREQLQ 2599



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1953 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2066

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2118

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2172

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2173 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2216

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2275

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2334

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2335 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2451 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2491

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2492 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2549

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2550 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2581

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2582 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2630

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2631 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2686 EDVR 2689



 Score =  106 bits (265), Expect = 2e-22
 Identities = 283/1380 (20%), Positives = 541/1380 (39%), Gaps = 197/1380 (14%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 968  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1081

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1142 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1184

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1185 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1354

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1412

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1413 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1463

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1698

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1815

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1816 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1923

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1924 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2037

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2214

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2016
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2215 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2271



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 336/1836 (18%), Positives = 694/1836 (37%), Gaps = 231/1836 (12%)

Query: 339  LTELTLALENELLVTKNSIHQAALASFKAEIRHLLE-RVDQVVREKEKLRSDLDKAEKLK 397
            L  +   L+ E  + +  ++QA  A  ++++R L   +V Q   E E+   DLDKA+ + 
Sbjct: 394  LQRIVTKLQMEAGLCEEQLNQAD-ALLQSDVRLLAAGKVPQRAGEVER---DLDKADSMI 449

Query: 398  SLMASEV----DDHHAAIER--RNEYNLRK----LDEEYKERIAALKNELRKEREQILQQ 447
             L+ ++V    D  H   E+  R  Y L +    +  EY  R+ A       +  Q+  Q
Sbjct: 450  RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 509

Query: 448  AGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN-----ELLENAEKLAEYENLTN 502
            + ++R ELE    +      Y++D LA   +   R++      +L     +L  +  L  
Sbjct: 510  SVQRRPELEDSTLR------YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 563

Query: 503  KLQR---NLENVLAEKFGDLDPSSAEFF--------LQEERLTQMRNEYERQCRVLQDQV 551
             ++     +E   +++ G L P++   +        LQ  +L        R    L   V
Sbjct: 564  SIEEFRAKIERARSDE-GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 622

Query: 552  DELQSEL--------EEY------RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE- 596
                 EL        EE       R      +    ++   E+E     I+     G   
Sbjct: 623  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 682

Query: 597  --ECNPLNMSIEA-ELVIEQMKEQHHRDICCLRLELEDKVRHYE--KQLDETVVSCKKAQ 651
              E +P   ++E+ +  ++       +  CC+   L++   +++    + E     +K Q
Sbjct: 683  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 742

Query: 652  ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEE 711
            E +++++  +      ++ DL   + + Q +   L E     +   +  K  +Q+K    
Sbjct: 743  EALRRKYSCDRSATVTRLEDL---LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799

Query: 712  KTHLQEKLRLQHEMELKARLTQAQASFEREREG-LQSSAWTEEKVRGLTQELEQFHQEQL 770
               ++ +L L    + K          E +  G  Q S W     + L+    +     +
Sbjct: 800  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW-----KVLSSSGSEAAVPSV 854

Query: 771  TSLVEKHTLEKEELRKELLEKHQRELQ-------EGREKMETECNRRTSQIEAQFQSDCQ 823
              LV     E +E    L  +HQ  +        + +  +  +  RR  Q+   +     
Sbjct: 855  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 914

Query: 824  KVT--ERCESALQSLEGRYRQELKDLQEQQR---EEKSQWEFEKDELTQECAEAQELLKE 878
            +    E    AL SLE  Y+  L+D Q+      E++   E E    +    +  + L++
Sbjct: 915  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 974

Query: 879  TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE--TQQSLLSDQ 936
              + E      +++ +++  +   E   +  V R +L  D E  R  ++   +Q     +
Sbjct: 975  GAQEESRCQRCISELKDI--RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1032

Query: 937  ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA 996
            +  L     R   E E+VL     S    + R E LE+   +  Q      + +E +   
Sbjct: 1033 VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE-LELTLGKLEQVRSLSAIYLEKLKTI 1091

Query: 997  TCETADRERAEMSTEISRL-QSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQ 1055
            +      + AE   E+ R  + ++KE Q   + L  L++    + +   + +        
Sbjct: 1092 SLVIRGTQGAE---EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148

Query: 1056 GEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-LEPGLVMSSCLDEPATE 1114
                L    +V   LQ+ H +   E  +    +++L +R Q  L    V    L++   +
Sbjct: 1149 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1208

Query: 1115 --FFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEE 1172
              ++  +A+    +LQ  R +Q +        S    +++R   +     ++R   K+EE
Sbjct: 1209 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL-LEEIERHGEKVEE 1267

Query: 1173 SEASVEGF---------------SELE-------------NSEETRTESWELKNQISQLQ 1204
             +   + +               ++LE              SE    E  +L+   S+L 
Sbjct: 1268 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1327

Query: 1205 ---EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
                Q +   ++  R  E+++ L       +++   L  +  A  K + L E  ++    
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAEVEAALEKQRQLAEAHAQAKAQ 1385

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFR----LQDELKKMEEVTETFLSLEKSYDE---- 1313
             + E + ++ R  E +   +E   +  +    +Q+EL+++ + +E  +  +    E    
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445

Query: 1314 --VKIENEELNVLVLRLQ----------GKIEKL----QESVVQRCDCCLWEASLENLEI 1357
              ++IE EE+ V+ L+L+          G+++ L    +E+  Q+      +   E L  
Sbjct: 1446 SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA---QEEAERLRR 1501

Query: 1358 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTI 1416
            +      +  Q   E   RV++      E ++  Q LE    Q  E  +    A +    
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561

Query: 1417 QTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILV 1476
            Q        Q     E  +    F +K  Q + ++ E  +   +L+E   +  ++     
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1621

Query: 1477 KQKDVLSHGEKEEELKAMMH-DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
            + ++      +  +LKA     L++   E+ Q+  L + E+EK Q+E +          E
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAE 1680

Query: 1536 EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE 1595
            E ++   +L       E+  Q  E   Q+  A ++ +  L+ +  + + + Q L+ E   
Sbjct: 1681 EQAVRQRELA--EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738

Query: 1596 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTL- 1654
            L ++ +   +K QEL   L ++  + E    + A  E E    + K + +R + ++    
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK-QRLEAEAGRFR 1797

Query: 1655 -----VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSV---- 1705
                  + L A   E K Q  + +++    + E E++             +K++++    
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV-----------LAEKLAAIGEAT 1846

Query: 1706 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1763
               +  E  LKEKEA +E L     +LA+    + R           E Q+A  K+ +  
Sbjct: 1847 RLKTEAEIALKEKEAENERLR----RLAEDEAFQRR---------RLEEQAAQHKADIEE 1893

Query: 1764 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIA 1823
               +++   D+      ++ R K  +  T +++  +++E+++L    + A       E+ 
Sbjct: 1894 RLAQLRKASDS------ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947

Query: 1824 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN 1883
                  + +    S ++ +     ++QL  +E  R +   +  +  L    E  RQ ++ 
Sbjct: 1948 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007

Query: 1884 LLP--------KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
            L          +  + L          Q +L+ +    + Q E+      V Q    EQE
Sbjct: 2008 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK---EQE 2064

Query: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 1995
            L+      + L+++Q  LD+   E +  R  A  +            ++A     RE   
Sbjct: 2065 LQ------QTLQQEQSVLDQLRGEAEAARRAAEEA------------EEARVQAEREA-A 2105

Query: 1996 QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
            Q +RQ+ +AER+ Q  +E+ + R       + L  E
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1031 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1088

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1089 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1142

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1143 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1203 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1254

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1255 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1297

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1298 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1346

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1347 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1406

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1407 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1465

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1466 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1524

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1643

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1702

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1807

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1808 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2044

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2104

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2165 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2224

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2341

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2395

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2456 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2509

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2510 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1370

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1426

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1485

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1545

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1546 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1605

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1666 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1725

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1845

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1846 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2084

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2143

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2144 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2188

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2189 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2247

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2248 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2298

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2299 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2345

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2346 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2400

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2401 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2457

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2568

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2569 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2628

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2629 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2677



 Score =  172 bits (437), Expect = 2e-42
 Identities = 349/1690 (20%), Positives = 674/1690 (39%), Gaps = 264/1690 (15%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 938  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 996

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 997  AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1056

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1057 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1116

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1117 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1233 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1292

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1293 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1352

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1353 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1471 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1524

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1704

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1705 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1764

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1765 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1821

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1878

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1939 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 1996

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH- 1843
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412

Query: 1844 ----------------LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1887
                             + +E +LL  ++E +QT+ Q    + T + ++    E + L +
Sbjct: 2413 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKREC-DQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
             ++ +         EQEK  L++   D+  K Q     +  Q   +EQE + +    E  
Sbjct: 2473 RERFI---------EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523

Query: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
            +++Q + +E +   Q               +LQ L+QQ      R Q    Q +LL  E 
Sbjct: 2524 RRRQHEAEEGVRRKQE--------------ELQQLEQQ------RRQ----QEELLAEE- 2558

Query: 2007 INQHLQEELE 2016
             NQ L+E+L+
Sbjct: 2559 -NQRLREQLQ 2567



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1861 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1920

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1921 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2034

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2086

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2140

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2141 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2184

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2243

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2244 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2302

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2303 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2419 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2459

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2460 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2517

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2518 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2549

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2550 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2598

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2599 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2653

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2654 EDVR 2657



 Score =  106 bits (265), Expect = 2e-22
 Identities = 283/1380 (20%), Positives = 541/1380 (39%), Gaps = 197/1380 (14%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 936  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 993

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 994  QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1049

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1050 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1109

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1110 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1152

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1153 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1322

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1323 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1380

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1381 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1431

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1432 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1491

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1551

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1611

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1666

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1783

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1784 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1891

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1892 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1949

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1950 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2005

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2182

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2016
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2183 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2239



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 336/1836 (18%), Positives = 694/1836 (37%), Gaps = 231/1836 (12%)

Query: 339  LTELTLALENELLVTKNSIHQAALASFKAEIRHLLE-RVDQVVREKEKLRSDLDKAEKLK 397
            L  +   L+ E  + +  ++QA  A  ++++R L   +V Q   E E+   DLDKA+ + 
Sbjct: 362  LQRIVTKLQMEAGLCEEQLNQAD-ALLQSDVRLLAAGKVPQRAGEVER---DLDKADSMI 417

Query: 398  SLMASEV----DDHHAAIER--RNEYNLRK----LDEEYKERIAALKNELRKEREQILQQ 447
             L+ ++V    D  H   E+  R  Y L +    +  EY  R+ A       +  Q+  Q
Sbjct: 418  RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 477

Query: 448  AGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN-----ELLENAEKLAEYENLTN 502
            + ++R ELE    +      Y++D LA   +   R++      +L     +L  +  L  
Sbjct: 478  SVQRRPELEDSTLR------YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 531

Query: 503  KLQR---NLENVLAEKFGDLDPSSAEFF--------LQEERLTQMRNEYERQCRVLQDQV 551
             ++     +E   +++ G L P++   +        LQ  +L        R    L   V
Sbjct: 532  SIEEFRAKIERARSDE-GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 590

Query: 552  DELQSEL--------EEY------RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE- 596
                 EL        EE       R      +    ++   E+E     I+     G   
Sbjct: 591  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 650

Query: 597  --ECNPLNMSIEA-ELVIEQMKEQHHRDICCLRLELEDKVRHYE--KQLDETVVSCKKAQ 651
              E +P   ++E+ +  ++       +  CC+   L++   +++    + E     +K Q
Sbjct: 651  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 710

Query: 652  ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEE 711
            E +++++  +      ++ DL   + + Q +   L E     +   +  K  +Q+K    
Sbjct: 711  EALRRKYSCDRSATVTRLEDL---LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 767

Query: 712  KTHLQEKLRLQHEMELKARLTQAQASFEREREG-LQSSAWTEEKVRGLTQELEQFHQEQL 770
               ++ +L L    + K          E +  G  Q S W     + L+    +     +
Sbjct: 768  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW-----KVLSSSGSEAAVPSV 822

Query: 771  TSLVEKHTLEKEELRKELLEKHQRELQ-------EGREKMETECNRRTSQIEAQFQSDCQ 823
              LV     E +E    L  +HQ  +        + +  +  +  RR  Q+   +     
Sbjct: 823  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 882

Query: 824  KVT--ERCESALQSLEGRYRQELKDLQEQQR---EEKSQWEFEKDELTQECAEAQELLKE 878
            +    E    AL SLE  Y+  L+D Q+      E++   E E    +    +  + L++
Sbjct: 883  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 942

Query: 879  TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE--TQQSLLSDQ 936
              + E      +++ +++  +   E   +  V R +L  D E  R  ++   +Q     +
Sbjct: 943  GAQEESRCQRCISELKDI--RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1000

Query: 937  ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA 996
            +  L     R   E E+VL     S    + R E LE+   +  Q      + +E +   
Sbjct: 1001 VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE-LELTLGKLEQVRSLSAIYLEKLKTI 1059

Query: 997  TCETADRERAEMSTEISRL-QSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQ 1055
            +      + AE   E+ R  + ++KE Q   + L  L++    + +   + +        
Sbjct: 1060 SLVIRGTQGAE---EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1116

Query: 1056 GEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-LEPGLVMSSCLDEPATE 1114
                L    +V   LQ+ H +   E  +    +++L +R Q  L    V    L++   +
Sbjct: 1117 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1176

Query: 1115 --FFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEE 1172
              ++  +A+    +LQ  R +Q +        S    +++R   +     ++R   K+EE
Sbjct: 1177 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL-LEEIERHGEKVEE 1235

Query: 1173 SEASVEGF---------------SELE-------------NSEETRTESWELKNQISQLQ 1204
             +   + +               ++LE              SE    E  +L+   S+L 
Sbjct: 1236 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1295

Query: 1205 ---EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
                Q +   ++  R  E+++ L       +++   L  +  A  K + L E  ++    
Sbjct: 1296 TLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAEVEAALEKQRQLAEAHAQAKAQ 1353

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFR----LQDELKKMEEVTETFLSLEKSYDE---- 1313
             + E + ++ R  E +   +E   +  +    +Q+EL+++ + +E  +  +    E    
Sbjct: 1354 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1413

Query: 1314 --VKIENEELNVLVLRLQ----------GKIEKL----QESVVQRCDCCLWEASLENLEI 1357
              ++IE EE+ V+ L+L+          G+++ L    +E+  Q+      +   E L  
Sbjct: 1414 SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA---QEEAERLRR 1469

Query: 1358 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTI 1416
            +      +  Q   E   RV++      E ++  Q LE    Q  E  +    A +    
Sbjct: 1470 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1529

Query: 1417 QTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILV 1476
            Q        Q     E  +    F +K  Q + ++ E  +   +L+E   +  ++     
Sbjct: 1530 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1589

Query: 1477 KQKDVLSHGEKEEELKAMMH-DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
            + ++      +  +LKA     L++   E+ Q+  L + E+EK Q+E +          E
Sbjct: 1590 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAE 1648

Query: 1536 EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE 1595
            E ++   +L       E+  Q  E   Q+  A ++ +  L+ +  + + + Q L+ E   
Sbjct: 1649 EQAVRQRELA--EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1706

Query: 1596 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTL- 1654
            L ++ +   +K QEL   L ++  + E    + A  E E    + K + +R + ++    
Sbjct: 1707 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK-QRLEAEAGRFR 1765

Query: 1655 -----VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSV---- 1705
                  + L A   E K Q  + +++    + E E++             +K++++    
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV-----------LAEKLAAIGEAT 1814

Query: 1706 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1763
               +  E  LKEKEA +E L     +LA+    + R           E Q+A  K+ +  
Sbjct: 1815 RLKTEAEIALKEKEAENERLR----RLAEDEAFQRR---------RLEEQAAQHKADIEE 1861

Query: 1764 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIA 1823
               +++   D+      ++ R K  +  T +++  +++E+++L    + A       E+ 
Sbjct: 1862 RLAQLRKASDS------ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1915

Query: 1824 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN 1883
                  + +    S ++ +     ++QL  +E  R +   +  +  L    E  RQ ++ 
Sbjct: 1916 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1975

Query: 1884 LLP--------KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
            L          +  + L          Q +L+ +    + Q E+      V Q    EQE
Sbjct: 1976 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK---EQE 2032

Query: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 1995
            L+      + L+++Q  LD+   E +  R  A  +            ++A     RE   
Sbjct: 2033 LQ------QTLQQEQSVLDQLRGEAEAARRAAEEA------------EEARVQAEREA-A 2073

Query: 1996 QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
            Q +RQ+ +AER+ Q  +E+ + R       + L  E
Sbjct: 2074 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1200 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1257

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1258 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1311

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1312 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1372 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1423

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1424 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1466

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1467 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1515

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1516 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1576 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1634

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1635 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1693

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1812

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1871

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1976

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1977 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2213

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2273

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2334 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2393

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2510

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2564

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2625 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1539

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1595

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1654

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1714

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1715 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1774

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1835 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1894

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 2014

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 2015 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2253

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2312

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2313 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2357

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2358 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2416

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2417 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2467

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2468 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2514

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2515 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2569

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2626

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2737

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2738 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2797

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2798 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2846



 Score =  172 bits (437), Expect = 2e-42
 Identities = 349/1690 (20%), Positives = 674/1690 (39%), Gaps = 264/1690 (15%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 1107 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1165

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1166 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1225

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1226 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1285

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1286 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1402 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1461

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1462 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1521

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1522 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1640 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1693

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1873

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1874 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1933

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1934 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1990

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 2047

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 2108 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2165

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH- 1843
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581

Query: 1844 ----------------LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1887
                             + +E +LL  ++E +QT+ Q    + T + ++    E + L +
Sbjct: 2582 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKREC-DQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
             ++ +         EQEK  L++   D+  K Q     +  Q   +EQE + +    E  
Sbjct: 2642 RERFI---------EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692

Query: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
            +++Q + +E +   Q               +LQ L+QQ      R Q    Q +LL  E 
Sbjct: 2693 RRRQHEAEEGVRRKQE--------------ELQQLEQQ------RRQ----QEELLAEE- 2727

Query: 2007 INQHLQEELE 2016
             NQ L+E+L+
Sbjct: 2728 -NQRLREQLQ 2736



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 2089

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 2090 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2203

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2255

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2309

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2310 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2353

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2412

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2413 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2471

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2472 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2588 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2628

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2629 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2686

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2687 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2718

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2719 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2767

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2768 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2822

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2823 EDVR 2826



 Score =  106 bits (265), Expect = 2e-22
 Identities = 283/1380 (20%), Positives = 541/1380 (39%), Gaps = 197/1380 (14%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 1105 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1162

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1163 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1218

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1219 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1279 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1321

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1322 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1491

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1492 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1549

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1550 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1600

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1601 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1660

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1720

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1780

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1835

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1952

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1953 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 2060

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 2061 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2118

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 2119 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2174

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2351

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2016
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2352 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2408



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 336/1836 (18%), Positives = 694/1836 (37%), Gaps = 231/1836 (12%)

Query: 339  LTELTLALENELLVTKNSIHQAALASFKAEIRHLLE-RVDQVVREKEKLRSDLDKAEKLK 397
            L  +   L+ E  + +  ++QA  A  ++++R L   +V Q   E E+   DLDKA+ + 
Sbjct: 531  LQRIVTKLQMEAGLCEEQLNQAD-ALLQSDVRLLAAGKVPQRAGEVER---DLDKADSMI 586

Query: 398  SLMASEV----DDHHAAIER--RNEYNLRK----LDEEYKERIAALKNELRKEREQILQQ 447
             L+ ++V    D  H   E+  R  Y L +    +  EY  R+ A       +  Q+  Q
Sbjct: 587  RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 646

Query: 448  AGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN-----ELLENAEKLAEYENLTN 502
            + ++R ELE    +      Y++D LA   +   R++      +L     +L  +  L  
Sbjct: 647  SVQRRPELEDSTLR------YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 700

Query: 503  KLQR---NLENVLAEKFGDLDPSSAEFF--------LQEERLTQMRNEYERQCRVLQDQV 551
             ++     +E   +++ G L P++   +        LQ  +L        R    L   V
Sbjct: 701  SIEEFRAKIERARSDE-GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 759

Query: 552  DELQSEL--------EEY------RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE- 596
                 EL        EE       R      +    ++   E+E     I+     G   
Sbjct: 760  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 819

Query: 597  --ECNPLNMSIEA-ELVIEQMKEQHHRDICCLRLELEDKVRHYE--KQLDETVVSCKKAQ 651
              E +P   ++E+ +  ++       +  CC+   L++   +++    + E     +K Q
Sbjct: 820  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 879

Query: 652  ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEE 711
            E +++++  +      ++ DL   + + Q +   L E     +   +  K  +Q+K    
Sbjct: 880  EALRRKYSCDRSATVTRLEDL---LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 936

Query: 712  KTHLQEKLRLQHEMELKARLTQAQASFEREREG-LQSSAWTEEKVRGLTQELEQFHQEQL 770
               ++ +L L    + K          E +  G  Q S W     + L+    +     +
Sbjct: 937  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW-----KVLSSSGSEAAVPSV 991

Query: 771  TSLVEKHTLEKEELRKELLEKHQRELQ-------EGREKMETECNRRTSQIEAQFQSDCQ 823
              LV     E +E    L  +HQ  +        + +  +  +  RR  Q+   +     
Sbjct: 992  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 1051

Query: 824  KVT--ERCESALQSLEGRYRQELKDLQEQQR---EEKSQWEFEKDELTQECAEAQELLKE 878
            +    E    AL SLE  Y+  L+D Q+      E++   E E    +    +  + L++
Sbjct: 1052 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1111

Query: 879  TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE--TQQSLLSDQ 936
              + E      +++ +++  +   E   +  V R +L  D E  R  ++   +Q     +
Sbjct: 1112 GAQEESRCQRCISELKDI--RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1169

Query: 937  ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA 996
            +  L     R   E E+VL     S    + R E LE+   +  Q      + +E +   
Sbjct: 1170 VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE-LELTLGKLEQVRSLSAIYLEKLKTI 1228

Query: 997  TCETADRERAEMSTEISRL-QSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQ 1055
            +      + AE   E+ R  + ++KE Q   + L  L++    + +   + +        
Sbjct: 1229 SLVIRGTQGAE---EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1285

Query: 1056 GEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-LEPGLVMSSCLDEPATE 1114
                L    +V   LQ+ H +   E  +    +++L +R Q  L    V    L++   +
Sbjct: 1286 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1345

Query: 1115 --FFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEE 1172
              ++  +A+    +LQ  R +Q +        S    +++R   +     ++R   K+EE
Sbjct: 1346 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL-LEEIERHGEKVEE 1404

Query: 1173 SEASVEGF---------------SELE-------------NSEETRTESWELKNQISQLQ 1204
             +   + +               ++LE              SE    E  +L+   S+L 
Sbjct: 1405 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1464

Query: 1205 ---EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
                Q +   ++  R  E+++ L       +++   L  +  A  K + L E  ++    
Sbjct: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAEVEAALEKQRQLAEAHAQAKAQ 1522

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFR----LQDELKKMEEVTETFLSLEKSYDE---- 1313
             + E + ++ R  E +   +E   +  +    +Q+EL+++ + +E  +  +    E    
Sbjct: 1523 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1582

Query: 1314 --VKIENEELNVLVLRLQ----------GKIEKL----QESVVQRCDCCLWEASLENLEI 1357
              ++IE EE+ V+ L+L+          G+++ L    +E+  Q+      +   E L  
Sbjct: 1583 SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA---QEEAERLRR 1638

Query: 1358 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTI 1416
            +      +  Q   E   RV++      E ++  Q LE    Q  E  +    A +    
Sbjct: 1639 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1698

Query: 1417 QTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILV 1476
            Q        Q     E  +    F +K  Q + ++ E  +   +L+E   +  ++     
Sbjct: 1699 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1758

Query: 1477 KQKDVLSHGEKEEELKAMMH-DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
            + ++      +  +LKA     L++   E+ Q+  L + E+EK Q+E +          E
Sbjct: 1759 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAE 1817

Query: 1536 EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE 1595
            E ++   +L       E+  Q  E   Q+  A ++ +  L+ +  + + + Q L+ E   
Sbjct: 1818 EQAVRQRELA--EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1875

Query: 1596 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTL- 1654
            L ++ +   +K QEL   L ++  + E    + A  E E    + K + +R + ++    
Sbjct: 1876 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK-QRLEAEAGRFR 1934

Query: 1655 -----VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSV---- 1705
                  + L A   E K Q  + +++    + E E++             +K++++    
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV-----------LAEKLAAIGEAT 1983

Query: 1706 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1763
               +  E  LKEKEA +E L     +LA+    + R           E Q+A  K+ +  
Sbjct: 1984 RLKTEAEIALKEKEAENERLR----RLAEDEAFQRR---------RLEEQAAQHKADIEE 2030

Query: 1764 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIA 1823
               +++   D+      ++ R K  +  T +++  +++E+++L    + A       E+ 
Sbjct: 2031 RLAQLRKASDS------ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 2084

Query: 1824 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN 1883
                  + +    S ++ +     ++QL  +E  R +   +  +  L    E  RQ ++ 
Sbjct: 2085 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2144

Query: 1884 LLP--------KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
            L          +  + L          Q +L+ +    + Q E+      V Q    EQE
Sbjct: 2145 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK---EQE 2201

Query: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 1995
            L+      + L+++Q  LD+   E +  R  A  +            ++A     RE   
Sbjct: 2202 LQ------QTLQQEQSVLDQLRGEAEAARRAAEEA------------EEARVQAEREA-A 2242

Query: 1996 QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
            Q +RQ+ +AER+ Q  +E+ + R       + L  E
Sbjct: 2243 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1041 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1098

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1099 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1152

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1153 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1213 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1264

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1265 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1307

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1308 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1356

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1357 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1417 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1475

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1476 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1534

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1653

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1712

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1817

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1818 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2054

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2351

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2405

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2466 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2520 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1380

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1436

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1495

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1555

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1556 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1615

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1676 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1735

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1796 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1855

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1856 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2094

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2153

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2154 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2198

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2199 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2257

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2258 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2308

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2309 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2355

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2356 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2410

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2411 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2467

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2578

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2579 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2638

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2639 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2687



 Score =  172 bits (437), Expect = 2e-42
 Identities = 349/1690 (20%), Positives = 674/1690 (39%), Gaps = 264/1690 (15%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 948  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1006

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1007 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1066

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1067 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1126

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1127 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1242

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1243 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1302

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1303 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1362

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1363 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1481 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1534

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1714

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1715 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1774

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1775 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1831

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1888

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1949 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2006

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH- 1843
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422

Query: 1844 ----------------LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1887
                             + +E +LL  ++E +QT+ Q    + T + ++    E + L +
Sbjct: 2423 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKREC-DQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
             ++ +         EQEK  L++   D+  K Q     +  Q   +EQE + +    E  
Sbjct: 2483 RERFI---------EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533

Query: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
            +++Q + +E +   Q               +LQ L+QQ      R Q    Q +LL  E 
Sbjct: 2534 RRRQHEAEEGVRRKQE--------------ELQQLEQQ------RRQ----QEELLAEE- 2568

Query: 2007 INQHLQEELE 2016
             NQ L+E+L+
Sbjct: 2569 -NQRLREQLQ 2577



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1930

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1931 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2044

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2096

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2150

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2151 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2194

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2253

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2254 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2312

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2313 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2429 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2469

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2470 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2527

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2528 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2559

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2560 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2608

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2609 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2663

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2664 EDVR 2667



 Score =  106 bits (265), Expect = 2e-22
 Identities = 283/1380 (20%), Positives = 541/1380 (39%), Gaps = 197/1380 (14%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 946  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1003

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1004 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1059

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1060 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1120 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1162

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1163 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1332

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1333 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1390

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1391 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1441

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1442 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1501

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1561

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1621

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1676

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1793

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1794 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1901

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1902 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1959

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1960 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2015

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2192

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2016
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2193 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2249



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 336/1836 (18%), Positives = 694/1836 (37%), Gaps = 231/1836 (12%)

Query: 339  LTELTLALENELLVTKNSIHQAALASFKAEIRHLLE-RVDQVVREKEKLRSDLDKAEKLK 397
            L  +   L+ E  + +  ++QA  A  ++++R L   +V Q   E E+   DLDKA+ + 
Sbjct: 372  LQRIVTKLQMEAGLCEEQLNQAD-ALLQSDVRLLAAGKVPQRAGEVER---DLDKADSMI 427

Query: 398  SLMASEV----DDHHAAIER--RNEYNLRK----LDEEYKERIAALKNELRKEREQILQQ 447
             L+ ++V    D  H   E+  R  Y L +    +  EY  R+ A       +  Q+  Q
Sbjct: 428  RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 487

Query: 448  AGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN-----ELLENAEKLAEYENLTN 502
            + ++R ELE    +      Y++D LA   +   R++      +L     +L  +  L  
Sbjct: 488  SVQRRPELEDSTLR------YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 541

Query: 503  KLQR---NLENVLAEKFGDLDPSSAEFF--------LQEERLTQMRNEYERQCRVLQDQV 551
             ++     +E   +++ G L P++   +        LQ  +L        R    L   V
Sbjct: 542  SIEEFRAKIERARSDE-GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 600

Query: 552  DELQSEL--------EEY------RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE- 596
                 EL        EE       R      +    ++   E+E     I+     G   
Sbjct: 601  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 660

Query: 597  --ECNPLNMSIEA-ELVIEQMKEQHHRDICCLRLELEDKVRHYE--KQLDETVVSCKKAQ 651
              E +P   ++E+ +  ++       +  CC+   L++   +++    + E     +K Q
Sbjct: 661  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 720

Query: 652  ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEE 711
            E +++++  +      ++ DL   + + Q +   L E     +   +  K  +Q+K    
Sbjct: 721  EALRRKYSCDRSATVTRLEDL---LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 777

Query: 712  KTHLQEKLRLQHEMELKARLTQAQASFEREREG-LQSSAWTEEKVRGLTQELEQFHQEQL 770
               ++ +L L    + K          E +  G  Q S W     + L+    +     +
Sbjct: 778  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW-----KVLSSSGSEAAVPSV 832

Query: 771  TSLVEKHTLEKEELRKELLEKHQRELQ-------EGREKMETECNRRTSQIEAQFQSDCQ 823
              LV     E +E    L  +HQ  +        + +  +  +  RR  Q+   +     
Sbjct: 833  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 892

Query: 824  KVT--ERCESALQSLEGRYRQELKDLQEQQR---EEKSQWEFEKDELTQECAEAQELLKE 878
            +    E    AL SLE  Y+  L+D Q+      E++   E E    +    +  + L++
Sbjct: 893  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 952

Query: 879  TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE--TQQSLLSDQ 936
              + E      +++ +++  +   E   +  V R +L  D E  R  ++   +Q     +
Sbjct: 953  GAQEESRCQRCISELKDI--RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1010

Query: 937  ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA 996
            +  L     R   E E+VL     S    + R E LE+   +  Q      + +E +   
Sbjct: 1011 VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE-LELTLGKLEQVRSLSAIYLEKLKTI 1069

Query: 997  TCETADRERAEMSTEISRL-QSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQ 1055
            +      + AE   E+ R  + ++KE Q   + L  L++    + +   + +        
Sbjct: 1070 SLVIRGTQGAE---EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1126

Query: 1056 GEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-LEPGLVMSSCLDEPATE 1114
                L    +V   LQ+ H +   E  +    +++L +R Q  L    V    L++   +
Sbjct: 1127 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1186

Query: 1115 --FFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEE 1172
              ++  +A+    +LQ  R +Q +        S    +++R   +     ++R   K+EE
Sbjct: 1187 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL-LEEIERHGEKVEE 1245

Query: 1173 SEASVEGF---------------SELE-------------NSEETRTESWELKNQISQLQ 1204
             +   + +               ++LE              SE    E  +L+   S+L 
Sbjct: 1246 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1305

Query: 1205 ---EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
                Q +   ++  R  E+++ L       +++   L  +  A  K + L E  ++    
Sbjct: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAEVEAALEKQRQLAEAHAQAKAQ 1363

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFR----LQDELKKMEEVTETFLSLEKSYDE---- 1313
             + E + ++ R  E +   +E   +  +    +Q+EL+++ + +E  +  +    E    
Sbjct: 1364 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1423

Query: 1314 --VKIENEELNVLVLRLQ----------GKIEKL----QESVVQRCDCCLWEASLENLEI 1357
              ++IE EE+ V+ L+L+          G+++ L    +E+  Q+      +   E L  
Sbjct: 1424 SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA---QEEAERLRR 1479

Query: 1358 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTI 1416
            +      +  Q   E   RV++      E ++  Q LE    Q  E  +    A +    
Sbjct: 1480 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1539

Query: 1417 QTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILV 1476
            Q        Q     E  +    F +K  Q + ++ E  +   +L+E   +  ++     
Sbjct: 1540 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1599

Query: 1477 KQKDVLSHGEKEEELKAMMH-DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
            + ++      +  +LKA     L++   E+ Q+  L + E+EK Q+E +          E
Sbjct: 1600 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAE 1658

Query: 1536 EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE 1595
            E ++   +L       E+  Q  E   Q+  A ++ +  L+ +  + + + Q L+ E   
Sbjct: 1659 EQAVRQRELA--EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1716

Query: 1596 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTL- 1654
            L ++ +   +K QEL   L ++  + E    + A  E E    + K + +R + ++    
Sbjct: 1717 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK-QRLEAEAGRFR 1775

Query: 1655 -----VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSV---- 1705
                  + L A   E K Q  + +++    + E E++             +K++++    
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV-----------LAEKLAAIGEAT 1824

Query: 1706 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1763
               +  E  LKEKEA +E L     +LA+    + R           E Q+A  K+ +  
Sbjct: 1825 RLKTEAEIALKEKEAENERLR----RLAEDEAFQRR---------RLEEQAAQHKADIEE 1871

Query: 1764 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIA 1823
               +++   D+      ++ R K  +  T +++  +++E+++L    + A       E+ 
Sbjct: 1872 RLAQLRKASDS------ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1925

Query: 1824 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN 1883
                  + +    S ++ +     ++QL  +E  R +   +  +  L    E  RQ ++ 
Sbjct: 1926 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1985

Query: 1884 LLP--------KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
            L          +  + L          Q +L+ +    + Q E+      V Q    EQE
Sbjct: 1986 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK---EQE 2042

Query: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 1995
            L+      + L+++Q  LD+   E +  R  A  +            ++A     RE   
Sbjct: 2043 LQ------QTLQQEQSVLDQLRGEAEAARRAAEEA------------EEARVQAEREA-A 2083

Query: 1996 QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
            Q +RQ+ +AER+ Q  +E+ + R       + L  E
Sbjct: 2084 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1049 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1106

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1107 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1160

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1221 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1272

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1273 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1315

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1316 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1364

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1365 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1424

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1425 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1483

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1484 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1542

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1661

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1662 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1720

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1781 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1825

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1826 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1883

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2062

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2122

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2183 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2359

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2413

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2474 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2527

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2528 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1271 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1330

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1388

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1444

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1503

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1563

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1564 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1623

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1683

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1684 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1743

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1744 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1804 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1863

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1864 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2102

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2161

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2162 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2206

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2207 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2265

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2266 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2316

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2317 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2363

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2364 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2418

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2419 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2475

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2586

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2587 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2646

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2647 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2695



 Score =  172 bits (437), Expect = 2e-42
 Identities = 349/1690 (20%), Positives = 674/1690 (39%), Gaps = 264/1690 (15%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 956  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1014

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1015 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1074

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1075 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1134

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1135 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1251 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1310

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1311 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1370

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1371 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1489 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1542

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1722

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1723 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1782

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1783 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1839

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1896

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1957 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2014

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH- 1843
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430

Query: 1844 ----------------LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1887
                             + +E +LL  ++E +QT+ Q    + T + ++    E + L +
Sbjct: 2431 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKREC-DQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
             ++ +         EQEK  L++   D+  K Q     +  Q   +EQE + +    E  
Sbjct: 2491 RERFI---------EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541

Query: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
            +++Q + +E +   Q               +LQ L+QQ      R Q    Q +LL  E 
Sbjct: 2542 RRRQHEAEEGVRRKQE--------------ELQQLEQQ------RRQ----QEELLAEE- 2576

Query: 2007 INQHLQEELE 2016
             NQ L+E+L+
Sbjct: 2577 -NQRLREQLQ 2585



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1879 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1938

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1939 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2052

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2104

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2105 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2158

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2159 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2202

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2261

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2262 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2320

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2321 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2437 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2477

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2478 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2535

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2536 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2567

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2568 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2616

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2617 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2671

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2672 EDVR 2675



 Score =  106 bits (265), Expect = 2e-22
 Identities = 283/1380 (20%), Positives = 541/1380 (39%), Gaps = 197/1380 (14%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 954  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1011

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1012 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1067

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1068 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1127

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1128 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1170

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1171 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1340

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1341 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1398

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1399 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1449

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1450 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1509

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1569

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1629

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1684

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1801

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1802 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1909

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1910 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1967

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1968 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2023

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2200

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2016
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2201 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2257



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 336/1836 (18%), Positives = 694/1836 (37%), Gaps = 231/1836 (12%)

Query: 339  LTELTLALENELLVTKNSIHQAALASFKAEIRHLLE-RVDQVVREKEKLRSDLDKAEKLK 397
            L  +   L+ E  + +  ++QA  A  ++++R L   +V Q   E E+   DLDKA+ + 
Sbjct: 380  LQRIVTKLQMEAGLCEEQLNQAD-ALLQSDVRLLAAGKVPQRAGEVER---DLDKADSMI 435

Query: 398  SLMASEV----DDHHAAIER--RNEYNLRK----LDEEYKERIAALKNELRKEREQILQQ 447
             L+ ++V    D  H   E+  R  Y L +    +  EY  R+ A       +  Q+  Q
Sbjct: 436  RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 495

Query: 448  AGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN-----ELLENAEKLAEYENLTN 502
            + ++R ELE    +      Y++D LA   +   R++      +L     +L  +  L  
Sbjct: 496  SVQRRPELEDSTLR------YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 549

Query: 503  KLQR---NLENVLAEKFGDLDPSSAEFF--------LQEERLTQMRNEYERQCRVLQDQV 551
             ++     +E   +++ G L P++   +        LQ  +L        R    L   V
Sbjct: 550  SIEEFRAKIERARSDE-GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 608

Query: 552  DELQSEL--------EEY------RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE- 596
                 EL        EE       R      +    ++   E+E     I+     G   
Sbjct: 609  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 668

Query: 597  --ECNPLNMSIEA-ELVIEQMKEQHHRDICCLRLELEDKVRHYE--KQLDETVVSCKKAQ 651
              E +P   ++E+ +  ++       +  CC+   L++   +++    + E     +K Q
Sbjct: 669  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 728

Query: 652  ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEE 711
            E +++++  +      ++ DL   + + Q +   L E     +   +  K  +Q+K    
Sbjct: 729  EALRRKYSCDRSATVTRLEDL---LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 785

Query: 712  KTHLQEKLRLQHEMELKARLTQAQASFEREREG-LQSSAWTEEKVRGLTQELEQFHQEQL 770
               ++ +L L    + K          E +  G  Q S W     + L+    +     +
Sbjct: 786  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW-----KVLSSSGSEAAVPSV 840

Query: 771  TSLVEKHTLEKEELRKELLEKHQRELQ-------EGREKMETECNRRTSQIEAQFQSDCQ 823
              LV     E +E    L  +HQ  +        + +  +  +  RR  Q+   +     
Sbjct: 841  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 900

Query: 824  KVT--ERCESALQSLEGRYRQELKDLQEQQR---EEKSQWEFEKDELTQECAEAQELLKE 878
            +    E    AL SLE  Y+  L+D Q+      E++   E E    +    +  + L++
Sbjct: 901  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 960

Query: 879  TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE--TQQSLLSDQ 936
              + E      +++ +++  +   E   +  V R +L  D E  R  ++   +Q     +
Sbjct: 961  GAQEESRCQRCISELKDI--RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1018

Query: 937  ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA 996
            +  L     R   E E+VL     S    + R E LE+   +  Q      + +E +   
Sbjct: 1019 VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE-LELTLGKLEQVRSLSAIYLEKLKTI 1077

Query: 997  TCETADRERAEMSTEISRL-QSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQ 1055
            +      + AE   E+ R  + ++KE Q   + L  L++    + +   + +        
Sbjct: 1078 SLVIRGTQGAE---EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1134

Query: 1056 GEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-LEPGLVMSSCLDEPATE 1114
                L    +V   LQ+ H +   E  +    +++L +R Q  L    V    L++   +
Sbjct: 1135 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1194

Query: 1115 --FFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEE 1172
              ++  +A+    +LQ  R +Q +        S    +++R   +     ++R   K+EE
Sbjct: 1195 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL-LEEIERHGEKVEE 1253

Query: 1173 SEASVEGF---------------SELE-------------NSEETRTESWELKNQISQLQ 1204
             +   + +               ++LE              SE    E  +L+   S+L 
Sbjct: 1254 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1313

Query: 1205 ---EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
                Q +   ++  R  E+++ L       +++   L  +  A  K + L E  ++    
Sbjct: 1314 TLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAEVEAALEKQRQLAEAHAQAKAQ 1371

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFR----LQDELKKMEEVTETFLSLEKSYDE---- 1313
             + E + ++ R  E +   +E   +  +    +Q+EL+++ + +E  +  +    E    
Sbjct: 1372 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1431

Query: 1314 --VKIENEELNVLVLRLQ----------GKIEKL----QESVVQRCDCCLWEASLENLEI 1357
              ++IE EE+ V+ L+L+          G+++ L    +E+  Q+      +   E L  
Sbjct: 1432 SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA---QEEAERLRR 1487

Query: 1358 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTI 1416
            +      +  Q   E   RV++      E ++  Q LE    Q  E  +    A +    
Sbjct: 1488 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1547

Query: 1417 QTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILV 1476
            Q        Q     E  +    F +K  Q + ++ E  +   +L+E   +  ++     
Sbjct: 1548 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1607

Query: 1477 KQKDVLSHGEKEEELKAMMH-DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
            + ++      +  +LKA     L++   E+ Q+  L + E+EK Q+E +          E
Sbjct: 1608 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAE 1666

Query: 1536 EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE 1595
            E ++   +L       E+  Q  E   Q+  A ++ +  L+ +  + + + Q L+ E   
Sbjct: 1667 EQAVRQRELA--EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1724

Query: 1596 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTL- 1654
            L ++ +   +K QEL   L ++  + E    + A  E E    + K + +R + ++    
Sbjct: 1725 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK-QRLEAEAGRFR 1783

Query: 1655 -----VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSV---- 1705
                  + L A   E K Q  + +++    + E E++             +K++++    
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV-----------LAEKLAAIGEAT 1832

Query: 1706 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1763
               +  E  LKEKEA +E L     +LA+    + R           E Q+A  K+ +  
Sbjct: 1833 RLKTEAEIALKEKEAENERLR----RLAEDEAFQRR---------RLEEQAAQHKADIEE 1879

Query: 1764 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIA 1823
               +++   D+      ++ R K  +  T +++  +++E+++L    + A       E+ 
Sbjct: 1880 RLAQLRKASDS------ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1933

Query: 1824 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN 1883
                  + +    S ++ +     ++QL  +E  R +   +  +  L    E  RQ ++ 
Sbjct: 1934 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1993

Query: 1884 LLP--------KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
            L          +  + L          Q +L+ +    + Q E+      V Q    EQE
Sbjct: 1994 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK---EQE 2050

Query: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 1995
            L+      + L+++Q  LD+   E +  R  A  +            ++A     RE   
Sbjct: 2051 LQ------QTLQQEQSVLDQLRGEAEAARRAAEEA------------EEARVQAEREA-A 2091

Query: 1996 QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
            Q +RQ+ +AER+ Q  +E+ + R       + L  E
Sbjct: 2092 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1090 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1147

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1148 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1201

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1202 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1262 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1313

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1314 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1356

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1357 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1405

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1406 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1465

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1466 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1524

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1525 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1583

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1702

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1761

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1866

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1867 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2103

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2163

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2224 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2283

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2400

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2454

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2515 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2569 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1371

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1429

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1485

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1544

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1604

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1605 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1664

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1724

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1725 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1784

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1785 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1845 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1904

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1905 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2143

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2202

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2203 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2247

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2248 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2306

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2307 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2357

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2358 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2404

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2405 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2459

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2460 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2516

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2627

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2628 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2687

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2688 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2736



 Score =  172 bits (437), Expect = 2e-42
 Identities = 349/1690 (20%), Positives = 674/1690 (39%), Gaps = 264/1690 (15%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 997  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1055

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1056 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1115

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1116 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1175

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1176 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1291

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1292 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1351

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1352 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1411

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1412 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1530 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1583

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1763

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1764 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1823

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1824 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1880

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1937

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1998 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2055

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH- 1843
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471

Query: 1844 ----------------LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1887
                             + +E +LL  ++E +QT+ Q    + T + ++    E + L +
Sbjct: 2472 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKREC-DQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
             ++ +         EQEK  L++   D+  K Q     +  Q   +EQE + +    E  
Sbjct: 2532 RERFI---------EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582

Query: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
            +++Q + +E +   Q               +LQ L+QQ      R Q    Q +LL  E 
Sbjct: 2583 RRRQHEAEEGVRRKQE--------------ELQQLEQQ------RRQ----QEELLAEE- 2617

Query: 2007 INQHLQEELE 2016
             NQ L+E+L+
Sbjct: 2618 -NQRLREQLQ 2626



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1980 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2093

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2145

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2146 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2199

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2200 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2243

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2302

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2303 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2361

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2362 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2478 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2518

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2519 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2576

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2577 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2608

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2609 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2657

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2658 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2712

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2713 EDVR 2716



 Score =  106 bits (265), Expect = 2e-22
 Identities = 283/1380 (20%), Positives = 541/1380 (39%), Gaps = 197/1380 (14%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 995  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1052

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1053 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1108

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1109 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1168

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1169 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1211

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1212 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1381

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1382 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1439

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1440 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1490

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1491 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1550

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1610

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1670

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1725

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1842

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1843 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1950

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1951 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2008

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 2009 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2064

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2241

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2016
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2242 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2298



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 336/1836 (18%), Positives = 694/1836 (37%), Gaps = 231/1836 (12%)

Query: 339  LTELTLALENELLVTKNSIHQAALASFKAEIRHLLE-RVDQVVREKEKLRSDLDKAEKLK 397
            L  +   L+ E  + +  ++QA  A  ++++R L   +V Q   E E+   DLDKA+ + 
Sbjct: 421  LQRIVTKLQMEAGLCEEQLNQAD-ALLQSDVRLLAAGKVPQRAGEVER---DLDKADSMI 476

Query: 398  SLMASEV----DDHHAAIER--RNEYNLRK----LDEEYKERIAALKNELRKEREQILQQ 447
             L+ ++V    D  H   E+  R  Y L +    +  EY  R+ A       +  Q+  Q
Sbjct: 477  RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 536

Query: 448  AGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN-----ELLENAEKLAEYENLTN 502
            + ++R ELE    +      Y++D LA   +   R++      +L     +L  +  L  
Sbjct: 537  SVQRRPELEDSTLR------YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 590

Query: 503  KLQR---NLENVLAEKFGDLDPSSAEFF--------LQEERLTQMRNEYERQCRVLQDQV 551
             ++     +E   +++ G L P++   +        LQ  +L        R    L   V
Sbjct: 591  SIEEFRAKIERARSDE-GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 649

Query: 552  DELQSEL--------EEY------RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE- 596
                 EL        EE       R      +    ++   E+E     I+     G   
Sbjct: 650  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 709

Query: 597  --ECNPLNMSIEA-ELVIEQMKEQHHRDICCLRLELEDKVRHYE--KQLDETVVSCKKAQ 651
              E +P   ++E+ +  ++       +  CC+   L++   +++    + E     +K Q
Sbjct: 710  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 769

Query: 652  ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEE 711
            E +++++  +      ++ DL   + + Q +   L E     +   +  K  +Q+K    
Sbjct: 770  EALRRKYSCDRSATVTRLEDL---LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 826

Query: 712  KTHLQEKLRLQHEMELKARLTQAQASFEREREG-LQSSAWTEEKVRGLTQELEQFHQEQL 770
               ++ +L L    + K          E +  G  Q S W     + L+    +     +
Sbjct: 827  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW-----KVLSSSGSEAAVPSV 881

Query: 771  TSLVEKHTLEKEELRKELLEKHQRELQ-------EGREKMETECNRRTSQIEAQFQSDCQ 823
              LV     E +E    L  +HQ  +        + +  +  +  RR  Q+   +     
Sbjct: 882  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 941

Query: 824  KVT--ERCESALQSLEGRYRQELKDLQEQQR---EEKSQWEFEKDELTQECAEAQELLKE 878
            +    E    AL SLE  Y+  L+D Q+      E++   E E    +    +  + L++
Sbjct: 942  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1001

Query: 879  TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE--TQQSLLSDQ 936
              + E      +++ +++  +   E   +  V R +L  D E  R  ++   +Q     +
Sbjct: 1002 GAQEESRCQRCISELKDI--RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1059

Query: 937  ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA 996
            +  L     R   E E+VL     S    + R E LE+   +  Q      + +E +   
Sbjct: 1060 VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE-LELTLGKLEQVRSLSAIYLEKLKTI 1118

Query: 997  TCETADRERAEMSTEISRL-QSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQ 1055
            +      + AE   E+ R  + ++KE Q   + L  L++    + +   + +        
Sbjct: 1119 SLVIRGTQGAE---EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1175

Query: 1056 GEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-LEPGLVMSSCLDEPATE 1114
                L    +V   LQ+ H +   E  +    +++L +R Q  L    V    L++   +
Sbjct: 1176 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1235

Query: 1115 --FFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEE 1172
              ++  +A+    +LQ  R +Q +        S    +++R   +     ++R   K+EE
Sbjct: 1236 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL-LEEIERHGEKVEE 1294

Query: 1173 SEASVEGF---------------SELE-------------NSEETRTESWELKNQISQLQ 1204
             +   + +               ++LE              SE    E  +L+   S+L 
Sbjct: 1295 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1354

Query: 1205 ---EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
                Q +   ++  R  E+++ L       +++   L  +  A  K + L E  ++    
Sbjct: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAEVEAALEKQRQLAEAHAQAKAQ 1412

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFR----LQDELKKMEEVTETFLSLEKSYDE---- 1313
             + E + ++ R  E +   +E   +  +    +Q+EL+++ + +E  +  +    E    
Sbjct: 1413 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1472

Query: 1314 --VKIENEELNVLVLRLQ----------GKIEKL----QESVVQRCDCCLWEASLENLEI 1357
              ++IE EE+ V+ L+L+          G+++ L    +E+  Q+      +   E L  
Sbjct: 1473 SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA---QEEAERLRR 1528

Query: 1358 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTI 1416
            +      +  Q   E   RV++      E ++  Q LE    Q  E  +    A +    
Sbjct: 1529 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1588

Query: 1417 QTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILV 1476
            Q        Q     E  +    F +K  Q + ++ E  +   +L+E   +  ++     
Sbjct: 1589 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1648

Query: 1477 KQKDVLSHGEKEEELKAMMH-DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
            + ++      +  +LKA     L++   E+ Q+  L + E+EK Q+E +          E
Sbjct: 1649 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAE 1707

Query: 1536 EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE 1595
            E ++   +L       E+  Q  E   Q+  A ++ +  L+ +  + + + Q L+ E   
Sbjct: 1708 EQAVRQRELA--EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1765

Query: 1596 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTL- 1654
            L ++ +   +K QEL   L ++  + E    + A  E E    + K + +R + ++    
Sbjct: 1766 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK-QRLEAEAGRFR 1824

Query: 1655 -----VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSV---- 1705
                  + L A   E K Q  + +++    + E E++             +K++++    
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV-----------LAEKLAAIGEAT 1873

Query: 1706 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1763
               +  E  LKEKEA +E L     +LA+    + R           E Q+A  K+ +  
Sbjct: 1874 RLKTEAEIALKEKEAENERLR----RLAEDEAFQRR---------RLEEQAAQHKADIEE 1920

Query: 1764 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIA 1823
               +++   D+      ++ R K  +  T +++  +++E+++L    + A       E+ 
Sbjct: 1921 RLAQLRKASDS------ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1974

Query: 1824 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN 1883
                  + +    S ++ +     ++QL  +E  R +   +  +  L    E  RQ ++ 
Sbjct: 1975 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2034

Query: 1884 LLP--------KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
            L          +  + L          Q +L+ +    + Q E+      V Q    EQE
Sbjct: 2035 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK---EQE 2091

Query: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 1995
            L+      + L+++Q  LD+   E +  R  A  +            ++A     RE   
Sbjct: 2092 LQ------QTLQQEQSVLDQLRGEAEAARRAAEEA------------EEARVQAEREA-A 2132

Query: 1996 QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
            Q +RQ+ +AER+ Q  +E+ + R       + L  E
Sbjct: 2133 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2168


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score =  170 bits (431), Expect = 1e-41
 Identities = 342/1676 (20%), Positives = 710/1676 (42%), Gaps = 232/1676 (13%)

Query: 394  EKLKSLMASEVDDHHAAIERRNEYNLRKLDE----------EYKERIAALKNELRKEREQ 443
            ++LK   + E+DDH   +      + +KL E          +Y+ERI  L+N L++    
Sbjct: 219  KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSG 278

Query: 444  ILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNK 503
            +++    +  E+++ I+  + E+         S K+  +LE+++ +  +KL+  EN  + 
Sbjct: 279  VIETDLSKIYEMQKTIQVLQIEK-------VESTKKMEQLEDKIKDINKKLSSAENDRDI 331

Query: 504  LQRNLENVLAEK-------------FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQ 550
            L+R  E +  EK                L PS+ +   Q + +T+      +   V  ++
Sbjct: 332  LRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK---QSDTMTEKERILAQSASV--EE 386

Query: 551  VDELQSELEEYRAQGRVLRLPLKNSPSEEVEAN------SGGIEPEHGLGSEECNPLNMS 604
            V  LQ  L +  A+  ++RL   N  +   E N         +E E  L S+E   L MS
Sbjct: 387  VFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMS 444

Query: 605  -IEAELVIEQMKEQHHRDICC------LRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 657
             ++     E +K    RDI        LRL LE K +   + + E      + +E  +Q 
Sbjct: 445  LLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQN 504

Query: 658  HENETH--TLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHL 715
             E   H   ++ Q+S  +NE     G + + K           +EKK++  +LE++K  +
Sbjct: 505  QEATKHMILIKDQLSKQQNE-----GDSIISKLKQD-----LNDEKKRVH-QLEDDKMDI 553

Query: 716  QEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE 775
             ++L +Q E  +++ +        +++         E+KV  L  +L +  +  ++  ++
Sbjct: 554  TKELDVQKEKLIQSEVALNDLHLTKQK--------LEDKVENLVDQLNKSQESNVS--IQ 603

Query: 776  KHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQS 835
            K  LE     KE + +++ EL   R ++    N+ ++   + F+    K  ER E+ +++
Sbjct: 604  KENLE----LKEHIRQNEEELSRIRNELMQSLNQDSN---SNFKDTLLK--ER-EAEVRN 653

Query: 836  LEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL------- 888
            L+ +   EL+ L E  ++     + E ++L   C + +  L+E L      SL       
Sbjct: 654  LK-QNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVE 712

Query: 889  VLTQEREMLEKTY---KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHK 945
             L  E+  +E      K+ L     + ++ +++L + RN++ +   L  + +++L     
Sbjct: 713  TLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD 772

Query: 946  REL--------------REREEVLCQAGASEQLASQRLERLEMEHD---------QERQE 982
             E+              +E ++VL  +   ++  +Q + + E+  +         QE  +
Sbjct: 773  MEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD 832

Query: 983  MMSKLLAMENIHKATCETADRERAEMSTEISRLQ---SKIKEMQQATSPLS---MLQSGC 1036
              S+ L    I + T E  DR    M  E + LQ    +++E Q  T+P++    L S  
Sbjct: 833  KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVT 892

Query: 1037 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQ 1096
            ++  E        +S L   ++ LEE        +  H Q + E+        + Q ++Q
Sbjct: 893  ELASE--------VSQLNTIKEHLEE--------EIKHHQKIIED--------QNQSKMQ 928

Query: 1097 KLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLG 1156
             L+        +DE   +     A  T+ FL+++   +    T   + + L  +E +D+ 
Sbjct: 929  LLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH-EERQDIQ 987

Query: 1157 STGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW-----ELKNQISQLQEQLMMLC 1211
            +  +   Q  +V+      ++E  SE  +  +  TE       E + +I  L E+ + L 
Sbjct: 988  TDNSDIFQETKVQ----SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLT 1043

Query: 1212 ADCDRASEKKQDLLFDVSVLKKKLK---MLERIPEASPKYKLLYEDVSRENDCLQEELRM 1268
               D+ S+ +   L  + + +K L+   +  RI   S    ++Y         LQ++L+ 
Sbjct: 1044 KQIDQLSKDEVGKLTQI-IQQKDLEIQALHARISSTSHTQDVVY---------LQQQLQA 1093

Query: 1269 METRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1328
                 ++      E T E   L+ E  KM ++     + E +  +++ EN++L+    R 
Sbjct: 1094 YAMEREKVFAVLNEKTRENSHLKTEYHKMMDIV---AAKEAALIKLQDENKKLST---RF 1147

Query: 1329 QGKIEKLQESVVQRCDCCLWEASLE----NLEIEPDGNILQLNQTLEECVPRVRSVHHVI 1384
            +   + +    +Q     + E  +E    + + +    +LQ + T  E    V S  +  
Sbjct: 1148 ESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNE-AGGVNS--NQF 1204

Query: 1385 EECKQENQYLEGNTQLLEKVKAHEIAWL----HGTIQTHQERPRVQNQVILE-ENTTLL- 1438
            EE  QE   L+   + +E+ K   +  +    H + Q  +E  ++Q QV+++ +N + L 
Sbjct: 1205 EELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQ 1264

Query: 1439 ----GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM 1494
                G    + Q++  +     E  ++Q    +L     +L+ + D++S    +    ++
Sbjct: 1265 VDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIIS---PQLSSASL 1321

Query: 1495 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNE-------ITTLNEED-SISNLKLGT 1546
            +      C     K E+L   SE LQQE   LR         I TL E +  +S+    T
Sbjct: 1322 LTPQSAECLR-ASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAAT 1380

Query: 1547 LNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEK 1606
                ++E  Q    +KQ       + + LK++   +K K+ QL   N   + K ++N E 
Sbjct: 1381 SELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNEN-EL 1439

Query: 1607 LQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVK 1666
            L++    L E +   E + G    E  +  +    +E E   +Q + +  S+   L E +
Sbjct: 1440 LRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSM--MLREKE 1497

Query: 1667 IQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSC 1726
             + H + +E  L  ++L K K+  +  +L+   Q +++V S  EK +  ++   + + + 
Sbjct: 1498 FECHSM-KEKALAFEQLLKEKEQGKTGELN---QLLNAVKSMQEKTVVFQQERDQVMLAL 1553

Query: 1727 VDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMK 1786
              K  +++ L++ +  ++ ++     +   L++ L+ S       ED+     L     +
Sbjct: 1554 KQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLES-------EDSYTREALAAEDRE 1606

Query: 1787 SDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN 1846
            + LR   ++   L+++++S    ++NA  ++ + ++ +    L+   K+     L   ++
Sbjct: 1607 AKLR---KKVTVLEEKLVSSSNAMENASHQA-SVQVESLQEQLNVVSKQRDETALQLSVS 1662

Query: 1847 EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNP--TEQE 1904
            +EQ       ++    + N +  L H +++ + + S  L K QK L      N    E +
Sbjct: 1663 QEQV------KQYALSLANLQMVLEHFQQEEKAMYSAELEK-QKQLIAEWKKNAENLEGK 1715

Query: 1905 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEM 1960
             +SL+   D+       A+R   Q++  E+++E +  +NE  ++    + ++LM +
Sbjct: 1716 VISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSL 1771



 Score =  151 bits (381), Expect = 7e-36
 Identities = 306/1504 (20%), Positives = 634/1504 (42%), Gaps = 208/1504 (13%)

Query: 359  QAALASFKAEIRHL--LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD-HHAAIERRN 415
            Q AL+  + EI  L  L + + +  +  KL+  ++  EK KSL++ E ++   + ++  N
Sbjct: 391  QQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450

Query: 416  EYNLRKLDEEYKERIAALKNELR---KEREQILQQAGKQRLELEQEIEKAKTEENYIRDR 472
            EY + K        + +  ++LR   + +EQ L Q+  ++  L  EIE+   +       
Sbjct: 451  EYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKH 510

Query: 473  LALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEER 532
            + L   + S+ +NE      KL +  N   K    LE+   +   +LD       +Q+E+
Sbjct: 511  MILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELD-------VQKEK 563

Query: 533  LTQMR---NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEP 589
            L Q     N+     + L+D+V+ L  +L +                             
Sbjct: 564  LIQSEVALNDLHLTKQKLEDKVENLVDQLNK----------------------------- 594

Query: 590  EHGLGSEECNPLNMSIEAE-LVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK 648
                 S+E N   +SI+ E L +++   Q+  ++  +R EL   +            S  
Sbjct: 595  -----SQESN---VSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD---------SNS 637

Query: 649  KAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV-- 706
              ++ + +  E E   L++ +S+L+     L+  A  +K  + +     E+ + QL+   
Sbjct: 638  NFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697

Query: 707  ----KLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQEL 762
                +L  EK  + E L+++ + E++A L  A+     E    + +       R L    
Sbjct: 698  AGNNQLSLEKNTIVETLKME-KGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSA 756

Query: 763  EQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMET--ECNRRTSQIEAQFQS 820
             Q   E L  L +K  +E  EL+K + E+   + +E ++ + +  E  ++ +Q+  + + 
Sbjct: 757  LQLEHEHLIKLNQKKDMEIAELKKNI-EQMDTDHKETKDVLSSSLEEQKQLTQLINKKEI 815

Query: 821  DCQKVTERCESALQSLEGRYRQELK--DLQEQQREEKSQWEFEKDELTQECAEAQELLKE 878
              +K+ ER  S LQ    +Y Q L+  ++  Q  EEK +      E      E  E L+E
Sbjct: 816  FIEKLKER-SSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLRE 874

Query: 879  TLKRE------KTTSLVLTQEREMLE-KTYKEHLNSMVVERQQLLQD-----LEDLRNVS 926
               R       KT   V     E+ +  T KEHL   +   Q++++D     ++ L+++ 
Sbjct: 875  EQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQ 934

Query: 927  ETQQSL--LSDQILELKSSHKRELRER-EEVLCQAGASEQLASQ-RLERLEMEHDQER-- 980
            E ++ +     Q  ++ ++H +   E+ EE+       EQ+ +Q   ER +++ D     
Sbjct: 935  EQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIF 994

Query: 981  QEMMSKLLAMEN------IHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1034
            QE   + L +EN      + KA  E   +   E   EI  L  K   + +    LS  + 
Sbjct: 995  QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEV 1054

Query: 1035 G--CQVIGEEEVE-------------GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVK 1079
            G   Q+I ++++E                 + L QQ +    E   V   L     +  +
Sbjct: 1055 GKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLN----EKTR 1110

Query: 1080 ENVKMATEISRLQQRLQKLEPGLV--------MSSCLDEPATEFFGNTAEQTEPFLQQNR 1131
            EN  + TE  ++   +   E  L+        +S+  +    + F  T +     +++ +
Sbjct: 1111 ENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIRE-K 1169

Query: 1132 TKQVEGVTRR--HVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEET 1189
              +++ ++++   +L+ L+     +    G +S Q +E+  E  +   +     E  ++ 
Sbjct: 1170 DIEIDALSQKCQTLLAVLQTSSTGNEAG-GVNSNQFEELLQERDKLKQQVKKMEEWKQQV 1228

Query: 1190 RTESWELKNQISQLQEQLMMLCA----DCDRASEKKQDLLFDVSVLKKKLKMLERIPEAS 1245
             T    ++++ +QLQE+L  L A    D D  S+ + D    +   ++    L+   +  
Sbjct: 1229 MTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQEL 1288

Query: 1246 PKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL 1305
             + +     +    D L  +L ++  +   A     + +AE  R      K E ++E+  
Sbjct: 1289 AQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQ-SAECLRAS----KSEVLSESSE 1343

Query: 1306 SLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP-DGNIL 1364
             L++  +E++   +E +  +  LQ    +L +S+    +       LE  E E  D  I 
Sbjct: 1344 LLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSE-------LERKEHEQTDSEIK 1396

Query: 1365 QLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPR 1424
            QL +  ++ + ++     ++ + K + Q L  N     KV  +E+  L   +   +ER  
Sbjct: 1397 QLKEK-QDVLQKLLKEKDLLIKAKSD-QLLSSNENFTNKVNENEL--LRQAVTNLKERIL 1452

Query: 1425 V----------QNQVILE----ENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKE 1470
            +          +N+ I+E    + T     Q+ + +    + E E E   ++E     ++
Sbjct: 1453 ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQ 1512

Query: 1471 RVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI 1530
                L+K+K+    GE  + L A+    + T    Q++ +++    +K Q EN+ L+NE+
Sbjct: 1513 ----LLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQK-QMENTALQNEV 1567

Query: 1531 TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLD 1590
              L +++  SN +L  L   +  + +  ++  +E  A +     L+K+++ L+ K     
Sbjct: 1568 QRLRDKEFRSNQELERL---RNHLLESEDSYTREALAAEDREAKLRKKVTVLEEK----- 1619

Query: 1591 LENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQ 1650
            L ++  + +N+ +Q  +Q   + L E L        N   ++R++    L    E+ K Q
Sbjct: 1620 LVSSSNAMENASHQASVQV--ESLQEQL--------NVVSKQRDETALQLSVSQEQVK-Q 1668

Query: 1651 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE 1710
             +  +++L+  L       H  Q+E  +   ELEK KQL     ++++++   ++     
Sbjct: 1669 YALSLANLQMVLE------HFQQEEKAMYSAELEKQKQL-----IAEWKKNAENL---EG 1714

Query: 1711 KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQN 1770
            K++  +E L +E N+ +D    +S L  ++   +++ +  + Q+   +  L   Q+K+ +
Sbjct: 1715 KVISLQECL-DEANAALD---SASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMS 1770

Query: 1771 LEDT 1774
            L ++
Sbjct: 1771 LANS 1774



 Score =  149 bits (376), Expect = 3e-35
 Identities = 300/1542 (19%), Positives = 638/1542 (41%), Gaps = 195/1542 (12%)

Query: 605  IEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHT 664
            IEA   I + + +  + +C    +LE+K    E Q+ +   S +     ++Q+    +H 
Sbjct: 57   IEAIHAILRSENERLKKLCT---DLEEKHEASEIQIKQQSTSYRN---QLQQKEVEISHL 110

Query: 665  LEKQISDLKNEIAELQGQAAVLKE-----------------AHHEATCRHEEEKKQLQVK 707
              +QI+ L++++ +LQ  A  +                   +HH +    ++      + 
Sbjct: 111  KARQIA-LQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIIS 169

Query: 708  LEEEKTHLQEKL-RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE----- 761
             ++E   L  ++ RL+ E+     + Q   +   +          +  ++ L Q      
Sbjct: 170  SQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEI 229

Query: 762  ---------LEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR--- 809
                     L+  HQ++LT +  +H  E  +  + + E      Q G   +ET+ ++   
Sbjct: 230  DDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYE 289

Query: 810  --RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ 867
              +T Q+    + +  K  E+ E  ++ +  +      D ++  R E+ Q   EK ++ +
Sbjct: 290  MQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAEND-RDILRREQEQLNVEKRQIME 348

Query: 868  ECAEAQ-ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLED--LRN 924
            EC   + E  K      K +  +  +ER + +    E     V   QQ L D E+  +R 
Sbjct: 349  ECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEE----VFRLQQALSDAENEIMRL 404

Query: 925  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 984
             S  Q + L++  L+LK   + E+ E+E+ L      E   S  L +L  E++  +    
Sbjct: 405  SSLNQDNSLAEDNLKLKM--RIEVLEKEKSLLSQEKEELQMS--LLKLNNEYEVIKSTAT 460

Query: 985  SKLLAMENIHKATCETADRER------AEMSTEISRLQSKIKEMQQATSPLSMLQSGCQV 1038
              +     +H        +E+      +E  T I+ ++   ++ Q+AT  + +++     
Sbjct: 461  RDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQ--- 517

Query: 1039 IGEEEVEGDGALSLLQQG--------EQLLEENGDVLLSLQRAHEQAVKENVKMATEISR 1090
            + +++ EGD  +S L+Q          QL ++  D+   L    E+ ++  V +    + 
Sbjct: 518  LSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVAL----ND 573

Query: 1091 LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1150
            L    QKLE  +   + +D+       N + Q E    +   +Q E       LS + ++
Sbjct: 574  LHLTKQKLEDKV--ENLVDQLNKSQESNVSIQKENLELKEHIRQNE-----EELSRIRNE 626

Query: 1151 EVRDLGSTGTSSVQRQEVKIEESEAS--VEGFSELEN-SEETRTESWELKNQISQLQEQL 1207
             ++ L     S+ +   +K  E+E     +  SELE  +E  +  ++++K +     E+L
Sbjct: 627  LMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKME----NEKL 682

Query: 1208 MMLCADCDRASEK----KQDLLFDVSVLKKKLKM------------LERIPEASPKYKLL 1251
            ++ C D     E+       L  + + + + LKM             +R+ E + KY+  
Sbjct: 683  VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKT 742

Query: 1252 YEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME-EVTETFLSLEKS 1310
             E++S   +     L++    ++  ++ N++   E+  L+  +++M+ +  ET   L  S
Sbjct: 743  IEELSNARNLNTSALQL---EHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSS 799

Query: 1311 YDEVKIENEELN---VLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPD---GNIL 1364
             +E K   + +N   + + +L+ +  KLQE + +          L     E D   G++ 
Sbjct: 800  LEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMK 859

Query: 1365 QLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVK--AHEIAWLHGTIQTHQER 1422
            + N  L+E + R+R         +Q       + + L+ V   A E++ L+ TI+ H E 
Sbjct: 860  EENNHLQEELERLRE--------EQSRTAPVADPKTLDSVTELASEVSQLN-TIKEHLEE 910

Query: 1423 PRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVL 1482
                +Q I+E         D++      +  L+ +K ++ E  R   E++     Q  + 
Sbjct: 911  EIKHHQKIIE---------DQNQSKMQLLQSLQEQKKEMDEF-RYQHEQMNATHTQLFL- 959

Query: 1483 SHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1542
               EK+EE+K++   ++   +++ ++ + ++ ++  + QE  +    I   +E+  +S  
Sbjct: 960  ---EKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKA 1016

Query: 1543 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK-QISELKIKNQQLDLENTELSQK-- 1599
            +   L    +E   + + + ++N ++ K ++ L K ++ +L    QQ DLE   L  +  
Sbjct: 1017 ETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARIS 1076

Query: 1600 NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLE 1659
            ++ + + +  L Q+L     ++EK    + L E+ +E  +LK E  +       +V++ E
Sbjct: 1077 STSHTQDVVYLQQQLQAYAMEREKV--FAVLNEKTRENSHLKTEYHK----MMDIVAAKE 1130

Query: 1660 AELSEV-----KIQTHIVQQENHLLKDELEKMKQLHRCPD--LSDFQQKISSVLSYNEKL 1712
            A L ++     K+ T        + ++ ++ + ++ R  D  +    QK  ++L+  +  
Sbjct: 1131 AALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTS 1190

Query: 1713 LKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQ-------KSWEHQSASLKSQLVASQ 1765
                EA     N   + L +   L+ ++  M++ +       ++ +H+SA L+ +L   Q
Sbjct: 1191 STGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL--HQ 1248

Query: 1766 EKVQNLEDTVQNVNLQM---------SRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGK 1816
             + Q L D+  N  LQ+          + ++ L+   QE   ++  +  L        GK
Sbjct: 1249 LQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGK 1308

Query: 1817 --SWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSR 1874
                +P++++  S L  Q           +++E  +LL QE E L+  +Q   A +   +
Sbjct: 1309 LDIISPQLSS-ASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQ 1367

Query: 1875 EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQK----EQSPANRKVSQMN 1930
            E   +L  ++    +           T+ E   LK + D  QK    +      K  Q+ 
Sbjct: 1368 ENNHRLSDSIAATSELERKEH---EQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLL 1424

Query: 1931 SLEQELETIHLENEGLKKKQVKLDEQLM-------EMQHLRSTATPSPSPHAWDLQLLQQ 1983
            S  +       ENE L++    L E+++       +++        +      + Q LQ+
Sbjct: 1425 SSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQE 1484

Query: 1984 --QACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2023
                  M+ RE+  +      +A    Q L+E+ + +T E N
Sbjct: 1485 TNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELN 1526



 Score =  141 bits (355), Expect = 7e-33
 Identities = 361/1836 (19%), Positives = 735/1836 (40%), Gaps = 274/1836 (14%)

Query: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420
            +LAS   +I +  +  D ++   E++ ++L  +         E++  HA +   NE  L+
Sbjct: 22   SLASLTGQISNFTK--DMLMEGTEEVEAELPDSR------TKEIEAIHAILRSENE-RLK 72

Query: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQ---EIEKAKTEENYIRDRLALSL 477
            KL  + +E+  A          QI QQ+   R +L+Q   EI   K  +  ++D+L   L
Sbjct: 73   KLCTDLEEKHEA-------SEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQL---L 122

Query: 478  KENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR 537
            K  S  ++ +   A   A     ++     + +     F D D    +    ++ + ++ 
Sbjct: 123  KLQSAAQS-VPSGAGVPAT--TASSSFAYGISHH-PSAFHDDDMDFGDIISSQQEINRLS 178

Query: 538  NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEE 597
            NE  R    L+ +V   +   +  +AQG        NS   E+                 
Sbjct: 179  NEVSR----LESEVGHWRHIAQTSKAQGT------DNSDQSEI----------------- 211

Query: 598  CNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 657
            C   N       +I+++K+   ++I   + E+      ++++L E           + +R
Sbjct: 212  CKLQN-------IIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTE-----------ISRR 253

Query: 658  HENETHTLEKQISDLKNEIAEL----------------------QGQAAVLKEAHHEATC 695
            H  E       +SD +  I EL                      Q    VL+    E+T 
Sbjct: 254  HREE-------LSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTK 306

Query: 696  RHEEEKKQLQ---------------VKLEEEKTHLQEKLRLQHEMELKARLTQAQASFER 740
            + E+ + +++               ++ E+E+ +++++  ++    LK   ++ Q S  +
Sbjct: 307  KMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK 366

Query: 741  ------EREGLQSSAWTEEKVRGLTQELEQFHQE--QLTSLVEKHTLEKEEL----RKEL 788
                  E+E + + + + E+V  L Q L     E  +L+SL + ++L ++ L    R E+
Sbjct: 367  QSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEV 426

Query: 789  LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848
            LEK +  L + +E+++    +  ++ E    +  + ++   +S L  L  R   E K+ +
Sbjct: 427  LEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDIS--LDSELHDL--RLNLEAKEQE 482

Query: 849  -EQQREEKSQWEFEKDELTQECAEAQE---LLKETLKREKTTSLVLTQEREMLEKTYKEH 904
              Q   EK     E +EL ++  EA +   L+K+ L +++        E + +    K+ 
Sbjct: 483  LNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQ-------NEGDSIISKLKQD 535

Query: 905  LNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSH--KRELREREEVLCQA--GA 960
            LN       QL  D  D+    + Q+  L    + L   H  K++L ++ E L      +
Sbjct: 536  LNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKS 595

Query: 961  SEQLASQRLERLEM-EHDQERQEMMSKLL--AMENIHK-ATCETADRERAEMSTEISRLQ 1016
             E   S + E LE+ EH ++ +E +S++    M+++++ +     D    E   E+  L+
Sbjct: 596  QESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLK 655

Query: 1017 SKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ 1076
              + E++Q    L  +    ++  E+ V       +  Q E+ L  N  + L      E 
Sbjct: 656  QNLSELEQLNENLKKVAFDVKMENEKLVL--ACEDVRHQLEECLAGNNQLSLEKNTIVET 713

Query: 1077 AVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE---QTEPFLQQNRTK 1133
               E  ++  E+   ++RL  LE        ++E +     NT+    + E  ++ N+ K
Sbjct: 714  LKMEKGEIEAELCWAKKRL--LEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771

Query: 1134 QVEGVTRRHVLSDLEDD--EVRDLGSTG-------TSSVQRQEVKIEE-SEASVEGFSEL 1183
             +E    +  +  ++ D  E +D+ S+        T  + ++E+ IE+  E S +   EL
Sbjct: 772  DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEEL 831

Query: 1184 --------------ENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFD-V 1228
                          +  EE       +K + + LQE+L  L  +  R +        D V
Sbjct: 832  DKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSV 891

Query: 1229 SVLKKKLKML----ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELT 1284
            + L  ++  L    E + E    ++ + ED ++    L + L+  +   DE    ++++ 
Sbjct: 892  TELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMN 951

Query: 1285 AEVFRL----QDELKKMEEVTETF-LSLEKSYDEVKIEN----EELNVLVLRLQGKIEK- 1334
            A   +L     +E+K +++  E     L +   +++ +N    +E  V  L ++   EK 
Sbjct: 952  ATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKH 1011

Query: 1335 -LQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             L ++  +R    + E  LE +++  + NI    Q  +     V  +  +I++   E Q 
Sbjct: 1012 DLSKAETERLVKGIKERELE-IKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQA 1070

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAE 1453
            L  + ++       ++ +L   +Q +         V+ E+       + ++ +    +A 
Sbjct: 1071 L--HARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAA 1128

Query: 1454 LELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL- 1512
             E    KLQ+  +KL  R       +D+    E  + L  ++ +  I    + QK + L 
Sbjct: 1129 KEAALIKLQDENKKLSTRFE--SSGQDMFR--ETIQNLSRIIREKDIEIDALSQKCQTLL 1184

Query: 1513 --RYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQK 1570
                 S    +   +  N+   L +E      ++  +   ++++    + ++ E+A +Q+
Sbjct: 1185 AVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQE 1244

Query: 1571 MVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM------LCQ-KEK 1623
             +  L+ Q+      N +L ++ T L Q   QN+ KL+   Q L ++      LC  K+ 
Sbjct: 1245 ELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDL 1304

Query: 1624 EPGNSALEEREQEKFNL--KEELERCKVQSSTLVSS----LEAELSEVK-------IQTH 1670
              G   +   +    +L   +  E  +   S ++S     L+ EL E++           
Sbjct: 1305 LLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIR 1364

Query: 1671 IVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE------KLLKEKEAL----S 1720
             +Q+ NH L D +    +L R     + +Q  S +    E      KLLKEK+ L    S
Sbjct: 1365 TLQENNHRLSDSIAATSELER----KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420

Query: 1721 EELNSC----VDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQ---LVASQEKVQNLED 1773
            ++L S      +K+ ++ LL   +  +K+     E     LK +   +V +    +    
Sbjct: 1421 DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQ 1480

Query: 1774 TVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQL-QNAGGKSWAPEIATHPSGLHNQ 1832
             +Q  N++ S M   LR  + E  ++K++ ++  + L +   GK+       +      +
Sbjct: 1481 ALQETNMKFSMM---LREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQE 1537

Query: 1833 QKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1892
            +  +   + D +M   +Q    EN  LQ  VQ  + +   S +++ +L ++LL     + 
Sbjct: 1538 KTVVFQQERDQVMLALKQ-KQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSY- 1595

Query: 1893 NPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1952
                    T +   +  RE    +K      + VS  N++E       ++ E L+++   
Sbjct: 1596 --------TREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNV 1647

Query: 1953 LDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ--- 2009
            + +Q  E     S +      +A  L  LQ      +  E F Q ++ +  AE   Q   
Sbjct: 1648 VSKQRDETALQLSVSQEQVKQYALSLANLQ------MVLEHFQQEEKAMYSAELEKQKQL 1701

Query: 2010 --HLQEELENRTSETNTPQALLPEQRAVHADSYRRI 2043
                ++  EN   +  + Q  L E  A   DS  R+
Sbjct: 1702 IAEWKKNAENLEGKVISLQECLDEANAA-LDSASRL 1736



 Score =  141 bits (355), Expect = 7e-33
 Identities = 301/1442 (20%), Positives = 581/1442 (40%), Gaps = 251/1442 (17%)

Query: 319  IENSQEILKAL---DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLER 375
            + N  E++K+    D SLD  ++   L L  + + L    S  +  +A  +   R   E 
Sbjct: 448  LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEA 507

Query: 376  VDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKN 435
               ++  K++L    ++ + + S +  +++D    + +  +  +    E   ++   +++
Sbjct: 508  TKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQS 567

Query: 436  ELRKEREQILQQAGKQRLE-LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL 494
            E+      + +Q  + ++E L  ++ K++ E N    +  L LKE+ R   E        
Sbjct: 568  EVALNDLHLTKQKLEDKVENLVDQLNKSQ-ESNVSIQKENLELKEHIRQNEE-------- 618

Query: 495  AEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFLQEERLTQMRNEYERQCRVLQD--- 549
             E   + N+L ++L       F D  L    AE    ++ L+++    E   +V  D   
Sbjct: 619  -ELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKM 677

Query: 550  -------QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLN 602
                     ++++ +LEE  A    L L  KN+  E ++   G IE E  L   +   L 
Sbjct: 678  ENEKLVLACEDVRHQLEECLAGNNQLSLE-KNTIVETLKMEKGEIEAE--LCWAKKRLLE 734

Query: 603  MSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 662
             + + E  IE++    + +   L+LE E  ++  +K+ D  +   KK  E M   H+   
Sbjct: 735  EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK-DMEIAELKKNIEQMDTDHKETK 793

Query: 663  HTL------EKQISDLKNE----IAELQGQAAVLKE---AHHEATCRHE------EEKKQ 703
              L      +KQ++ L N+    I +L+ +++ L+E    + +A  ++E      EEK +
Sbjct: 794  DVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDR 853

Query: 704  LQVKLEEEKTHLQEKL-RLQHEM----------------ELKARLTQAQASFEREREGL- 745
                ++EE  HLQE+L RL+ E                 EL + ++Q     E   E + 
Sbjct: 854  SLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIK 913

Query: 746  ----------QSSAWTEEKVRGLTQELEQF--HQEQLTSLVEKHTLEKEELRKEL---LE 790
                      QS     + ++   +E+++F    EQ+ +   +  LEK+E  K L   +E
Sbjct: 914  HHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973

Query: 791  KHQRELQEGREKMETECNRRTSQIEAQF--------QSDCQKV-TERCESALQSLEGRYR 841
            + + +L E R+ ++T+ +    + + Q         + D  K  TER    ++  E    
Sbjct: 974  QIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE---- 1029

Query: 842  QELKDLQEQQREEKSQW-EFEKDEL--------------------------TQECAEAQE 874
             E+K L E+      Q  +  KDE+                          TQ+    Q+
Sbjct: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089

Query: 875  LLKE-TLKREKTTSLV--LTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS 931
             L+   ++REK  +++   T+E   L+  Y + ++ +  +   L++  ++ + +S   +S
Sbjct: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149

Query: 932  LLSDQILELKSSHKRELREREEVL------CQ-----------AGASEQLASQRLERLEM 974
               D   E   +  R +RE++  +      CQ              +  + S + E L  
Sbjct: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209

Query: 975  EHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1034
            E D+ +Q+ + K+   +     T +    E A++  E+ +LQ+++       S L     
Sbjct: 1210 ERDKLKQQ-VKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKL----- 1263

Query: 1035 GCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR 1094
                    +V+  G +   +Q E  L+  G  L  +Q +  Q       +      L  +
Sbjct: 1264 --------QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ-------LCNTKDLLLGK 1308

Query: 1095 LQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRD 1154
            L  + P L  +S L   + E     A ++E   + +   Q E    R  L + +D  +R 
Sbjct: 1309 LDIISPQLSSASLLTPQSAECL--RASKSEVLSESSELLQQELEELRKSLQE-KDATIRT 1365

Query: 1155 LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADC 1214
            L        Q    ++ +S A+    SELE  E  +T+S E+K Q+ + Q+ L  L  + 
Sbjct: 1366 L--------QENNHRLSDSIAAT---SELERKEHEQTDS-EIK-QLKEKQDVLQKLLKEK 1412

Query: 1215 DRASEKKQD-LLFDVSVLKKKLKMLERIPEASPKYK----LLYEDVSR---ENDCLQEEL 1266
            D   + K D LL        K+   E + +A    K    +L  D+ +   EN+ + E  
Sbjct: 1413 DLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY 1472

Query: 1267 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1326
            R  ET Y    E N + +  +   + E   M+E    F  L K  ++ K    ELN    
Sbjct: 1473 RGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGK--TGELN---- 1526

Query: 1327 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEE 1386
            +L   ++ +QE  V               + E D  +L L Q   E       V  + ++
Sbjct: 1527 QLLNAVKSMQEKTVV-------------FQQERDQVMLALKQKQMENTALQNEVQRLRDK 1573

Query: 1387 CKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV-ILEENTTLLGFQDKHF 1445
              + NQ LE   +L   +   E ++    +       +++ +V +LEE         ++ 
Sbjct: 1574 EFRSNQELE---RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENA 1630

Query: 1446 QHQATIAELELEKTKLQELTRKLKERVTILVKQKD--VLSHGEKEEELK---AMMHDLQI 1500
             HQA++                L+E++ ++ KQ+D   L     +E++K     + +LQ+
Sbjct: 1631 SHQASVQ------------VESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQM 1678

Query: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560
                 QQ+ E   Y +E  +Q+  I   +    N E  + +L+               E 
Sbjct: 1679 VLEHFQQE-EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQ---------------EC 1722

Query: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620
            + + NAA    +++  +   +L +K +Q++    EL ++N   QE L ++ ++L  +   
Sbjct: 1723 LDEANAA----LDSASRLTEQLDVKEEQIE----ELKRQNELRQEMLDDVQKKLMSLANS 1774

Query: 1621 KE 1622
             E
Sbjct: 1775 SE 1776


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  169 bits (428), Expect = 3e-41
 Identities = 296/1353 (21%), Positives = 565/1353 (41%), Gaps = 198/1353 (14%)

Query: 699  EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGL 758
            +E + LQ  L+EEK + +E   L+ E+E    L Q +A    + +GL + +  E  ++ L
Sbjct: 90   QEVQDLQASLKEEKWYSEE---LKKELEKYQGLQQQEA----KPDGLVTDSSAE--LQSL 140

Query: 759  TQELEQ-----FHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
             Q+LE+     F+ +Q+  L E+   +      ++  K+  E +  RE  E +  R T +
Sbjct: 141  EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE-RSLREAAEQKVTRLTEE 199

Query: 814  IEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQ 873
            +  +        TE  +          ++EL  +Q        + E E ++L  EC + Q
Sbjct: 200  LNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQ 259

Query: 874  ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLL 933
                    +  ++   ++Q R  L K  +E +   V E Q+L   + +L   ++T    L
Sbjct: 260  S-------QYASSEATISQLRSELAKGPQE-VAVYVQELQKLKSSVNELTQKNQT----L 307

Query: 934  SDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME-N 992
            ++ +L+ +  + +   +  E        E ++ + ++    + D + Q++ S+L A E +
Sbjct: 308  TENLLKKEQDYTKLEEKHNE--------ESVSKKNIQATLHQKDLDCQQLQSRLSASETS 359

Query: 993  IHKATCETADR---------ERAEMSTEISRLQSKIKEMQQAT-----------SPLSML 1032
            +H+   E +++         E +E+ T+   L+++ K++QQ             S ++ L
Sbjct: 360  LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL 419

Query: 1033 QSGCQVIGEEEVEGDGALSLLQQ--GEQLLEEN---GDVLLSLQRAHEQAVKENVKMATE 1087
             S       +  E  G L   +Q   E+L+++     D+ L L R  EQ +KE V  +TE
Sbjct: 420  HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ-LKEKVTNSTE 478

Query: 1088 ISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQ-----NRTKQVEGVTRRH 1142
               LQ +L K +        L +  T          E  L+Q      + + +E + ++ 
Sbjct: 479  ---LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535

Query: 1143 ------VLSDLEDDEVRDLGSTGTSSV--QRQEVKIEESEASVEGFSELENSEETRTESW 1194
                  +  + ED   +     G ++V  Q QE      E   +   +L+N  E+  ++ 
Sbjct: 536  KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKK---QDLLFDVSVLKKKLKMLERIPEASPKYKLL 1251
            E  N   Q+QEQ   L A  DR    +    +L   ++  K+K+  L+   +A  +  L 
Sbjct: 596  E--NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653

Query: 1252 YE--------DVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME----E 1299
             E        D+    D  Q  L+  +   ++      ++TA++   Q+   ++E    E
Sbjct: 654  AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713

Query: 1300 VTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP 1359
              E +LSLE+  +E++ + ++L    L ++   E+  + + Q+            L  + 
Sbjct: 714  YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ----------RQLNTDL 763

Query: 1360 DGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH 1419
            +    +L++ LE     V S      + +++++ LE   Q L K +  E   L    +T 
Sbjct: 764  ELRATELSKQLEMEKEIVSSTRL---DLQKKSEALESIKQKLTK-QEEEKQILKQDFETL 819

Query: 1420 QERPRVQNQVILEE-NTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ 1478
             +  ++Q++ +     TT+   Q    + +A + EL   K KL +++  LK         
Sbjct: 820  SQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK------ 873

Query: 1479 KDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEED 1537
                S  EKE +  KA + DL+ TC E++ ++++    + K Q+E   L+  +    E++
Sbjct: 874  ----SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE---LKKSLE--KEKE 924

Query: 1538 SISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1597
            +   LKL  LN  QE++ Q   T+KQ     Q++  N+ +     + K +Q++    EL 
Sbjct: 925  ASHQLKL-ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983

Query: 1598 ----QKNSQNQEKLQELNQRLTEMLCQKEK--------EPGNSALEE-------REQEKF 1638
                QK     +  Q+L Q   E+  +KEK        E      ++       RE E  
Sbjct: 984  IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043

Query: 1639 NLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ----ENHLLKDELEKMKQL-HRCP 1693
              +++L+  + + S     L +  +++  Q  ++Q+    +  L +D  +K +QL  RC 
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103

Query: 1694 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1753
             L D Q+         EK LKEKE ++E          KS L E      +QE K     
Sbjct: 1104 ALQDIQK---------EKSLKEKELVNE----------KSKLAEIEEIKCRQE-KEITKL 1143

Query: 1754 SASLKSQLVASQEKVQNLEDT-----VQNVNLQ--MSRMKSDLRVTQQEKEALKQEVMSL 1806
            +  LKS  + S +++ NL+D       Q + LQ     +K+ +   ++ ++ LK +V   
Sbjct: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKE 1203

Query: 1807 HKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNT 1866
             ++L+         E     + LH++ K        H  NE +  L  +   L   +   
Sbjct: 1204 EEELKK--------EFIEKEAKLHSEIKEKEVGMKKHEENEAK--LTMQITALNENLGTV 1253

Query: 1867 KAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-------DQFQKEQ 1919
            K E   S+ +V +LE        +      T+   + E+ +L   C       ++ Q + 
Sbjct: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKV 1313

Query: 1920 SPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1952
                RK+    +  QEL     EN+ L+ K  +
Sbjct: 1314 LELQRKLDNTTAAVQELGR---ENQSLQIKHTQ 1343



 Score =  164 bits (415), Expect = 8e-40
 Identities = 291/1350 (21%), Positives = 568/1350 (42%), Gaps = 241/1350 (17%)

Query: 367  AEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD------HHAAIERRNEYNLR 420
            AE++ L +++++   E   ++   D  E+  + +A+E+ D         ++    E  + 
Sbjct: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194

Query: 421  KLDEEYKER---IAALKNEL------------RKEREQILQQAGKQRLELEQEIEKAKTE 465
            +L EE  +    I  LK EL            +KE  Q+        LE E+E EK K E
Sbjct: 195  RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254

Query: 466  ENYIRDRLALSLKENSRLENELLENAEKLAEY-----------ENLTNKLQRNLENVLAE 514
               ++ + A S    S+L +EL +  +++A Y             LT K Q   EN+L +
Sbjct: 255  CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314

Query: 515  K--FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            +  +  L+    E  + ++ +    ++ +  C+ LQ ++   ++ L     +     L  
Sbjct: 315  EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-----LSE 369

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
            K   +++++     +E ++     E   L    E        KEQH        L+L+ +
Sbjct: 370  KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE-------KEQH-------GLQLQSE 415

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTL---EKQISDLKNEIAELQGQ----AAV 685
            +     +L ET     +A   +K++ +  +  L   E+Q++DL+ +++ L+ Q       
Sbjct: 416  INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475

Query: 686  LKEAHH--EATCRHEEEKKQLQ----VKLEEEKTHLQEKLRL-----QHEMELKARLTQA 734
              E  H  + T +  +E++ LQ     KL E +  L++ LR      Q    L+A L ++
Sbjct: 476  STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535

Query: 735  QAS---FEREREGLQSSAWTEEKVRGLTQELEQFH---QEQLTSLVEK-------HTLEK 781
            + +    E+ERE L +     E    +  +L++ +   QEQ+T L EK       H   +
Sbjct: 536  KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595

Query: 782  EELRKELLEK--HQRELQEGREKMETECNRRTSQIEAQFQSDCQ---KVTERCESALQSL 836
            E L  ++ E+  H R  Q+    +ET  N   SQ+    +   Q   ++  + E  L S 
Sbjct: 596  ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE-LLLSA 654

Query: 837  EGRYRQELKDLQ----------EQQREEKSQWEFEKDELTQECAEAQE---LLKETLKRE 883
            E     +  DLQ          + +++E ++   + D++T +  + QE    L+  LK  
Sbjct: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714

Query: 884  KTTSLVLTQEREMLEKTYKE-HLNSMVVE--RQQLLQDLEDLRNVS---ETQQSLLSDQI 937
            K   L L Q+ E LE   K+   +S+ V+  ++Q LQDL+  R ++   E + + LS Q+
Sbjct: 715  KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774

Query: 938  ---LELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 994
                E+ SS + +L+++ E L      ++L  Q  E+  ++ D E     +K+   E  +
Sbjct: 775  EMEKEIVSSTRLDLQKKSEAL--ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832

Query: 995  KATCETADRERAEMS-----TEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
            +      + ++ +M      TE+S ++ K+ ++  +      L++      +E  +G  A
Sbjct: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS------LKNSKSEFEKENQKGKAA 886

Query: 1050 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEIS-RLQQRLQKLEPGLVMSSCL 1108
            +  L++  + L+    V +      ++ +K++++   E S +L+  L  ++  L+ +   
Sbjct: 887  ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ-- 944

Query: 1109 DEPATEFFGNTAEQTEPFLQQ-----NRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1163
                     NT +Q E   QQ     N  KQ     ++ + +   + ++  L  T   + 
Sbjct: 945  ---------NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995

Query: 1164 QRQEV--KIEESEASVEGFSELENSEETRTESW-ELKNQISQLQEQLMMLCADCDRASEK 1220
             +Q++    +E  A  E  S L+N+ E   E++ +L++     + +L+    D     EK
Sbjct: 996  LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055

Query: 1221 ----KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEA 1276
                ++DL+ + + +  + K+++ +  A      L +D +++   LQE  + ++    E 
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAK---ATLEQDSAKKEQQLQERCKALQDIQKEK 1112

Query: 1277 LENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQ 1336
                KEL        +E  K+ E+ E     EK   E+   NEEL         K+E ++
Sbjct: 1113 SLKEKELV-------NEKSKLAEIEEIKCRQEK---EITKLNEELK------SHKLESIK 1156

Query: 1337 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG 1396
            E              + NL+   D   L + Q L E   +  S+   +E+ K+  Q L  
Sbjct: 1157 E--------------ITNLK---DAKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQIL-- 1196

Query: 1397 NTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELEL 1456
                                         ++QV  EE      F +K  +  + I E E+
Sbjct: 1197 -----------------------------KDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227

Query: 1457 EKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES 1516
               K +E   KL  ++T L             E L  +  + Q      Q++V  L  ++
Sbjct: 1228 GMKKHEENEAKLTMQITAL------------NENLGTVKKEWQ----SSQRRVSELEKQT 1271

Query: 1517 EKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1576
            + L+ E ++L  E T  N +D    L    L G  E      E ++ +   +Q+ ++N  
Sbjct: 1272 DDLRGEIAVL--EATVQNNQDERRALLERCLKGEGE-----IEKLQTKVLELQRKLDNTT 1324

Query: 1577 KQISELKIKNQQLDLENTE-LSQKNSQNQE 1605
              + EL  +NQ L +++T+ L++K +++ E
Sbjct: 1325 AAVQELGRENQSLQIKHTQALNRKWAEDNE 1354



 Score =  149 bits (377), Expect = 2e-35
 Identities = 239/1178 (20%), Positives = 498/1178 (42%), Gaps = 211/1178 (17%)

Query: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900
            RQE++DLQ   +EEK    +  +EL +E  + Q L ++  K +    LV     E+    
Sbjct: 89   RQEVQDLQASLKEEK----WYSEELKKELEKYQGLQQQEAKPD---GLVTDSSAEL---- 137

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960
              + L   + E Q    +++ ++++ E + + L+ +I ++KS +  E   RE        
Sbjct: 138  --QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE-------- 187

Query: 961  SEQLASQRLERLEMEHDQER---QEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1017
                A Q++ RL  E ++E    Q++ ++LL    I          + A +  E+ ++Q+
Sbjct: 188  ---AAEQKVTRLTEELNKEATVIQDLKTELLQRPGI---------EDVAVLKKELVQVQT 235

Query: 1018 KIKEMQ-QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ 1076
             +  M  +       L+  C+ +  +    +  +S L+                      
Sbjct: 236  LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR---------------------- 273

Query: 1077 AVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               E  K   E++   Q LQKL+  +   +  ++  TE   N  ++ + + +       E
Sbjct: 274  --SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE---NLLKKEQDYTKLEEKHNEE 328

Query: 1137 GVTRRHVLS-----DLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRT 1191
             V+++++ +     DL+  +++   S   +S+ R  V++ E   + +     E   E  T
Sbjct: 329  SVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK--EELSEVET 386

Query: 1192 ESWELKNQISQLQEQLMMLCADCDRASEKKQ---DLLFDVSVLKKKLKMLERIPEASPKY 1248
            +   LK +  QLQ+Q            EK+Q    L  +++ L  KL   ER        
Sbjct: 387  KYQHLKAEFKQLQQQ----------REEKEQHGLQLQSEINQLHSKLLETER-------- 428

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
                  +   +  L+E+ ++   +  +  +   +L  ++ RL+++LK  E+VT +   L+
Sbjct: 429  -----QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK--EKVTNS-TELQ 480

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRC----DCCLWEASLENLEIEPDGNIL 1364
               D+ K +++E   L      K+ + Q  + Q      D      +LE L  +   NI 
Sbjct: 481  HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540

Query: 1365 QLNQTLEECVPRVRSVH---HVIEECKQENQYL-EGNTQLLEKVKAHEIAWLHGTIQTHQ 1420
             L +  E+   ++++      V+ + +++N  L E  TQL EK+K           ++H+
Sbjct: 541  LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS--------ESHK 592

Query: 1421 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELE----KTKLQELTRKLKERVTILV 1476
            +     +  + E+   L   QD+    + ++ EL  +    K K+ +L  ++K +  +L+
Sbjct: 593  QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652

Query: 1477 --------KQKDVLSH--------GEKEEELK----------AMMHDLQITCSEMQQKVE 1510
                    ++ D+ +H         +K++EL           A + D Q  CS+++  ++
Sbjct: 653  SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712

Query: 1511 LLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQK 1570
              + +   L+Q+   L  +I  L E DS+       +  S+E+  Q  +  +Q N  ++ 
Sbjct: 713  EYKEKYLSLEQKTEELEGQIKKL-EADSLE------VKASKEQALQDLQQQRQLNTDLEL 765

Query: 1571 MVENLKKQISELK--IKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNS 1628
                L KQ+   K  + + +LDL+         +  E L+ + Q+LT+   ++EK+    
Sbjct: 766  RATELSKQLEMEKEIVSSTRLDLQ---------KKSEALESIKQKLTKQ--EEEKQILKQ 814

Query: 1629 ALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
              E   QE     EEL   ++Q++        EL +VK++   +  E   +KD+L K+  
Sbjct: 815  DFETLSQETKIQHEELNN-RIQTTV------TELQKVKMEKEALMTELSTVKDKLSKVSD 867

Query: 1689 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1748
                  L + + +        +  + + E   +EL   +    +++L E +   +K+  +
Sbjct: 868  -----SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK--ELKKSLE 920

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
              +  S  LK +L + QE++   ++T++    +  +++ ++   +Q  E  K+++ +L  
Sbjct: 921  KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 980

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1868
            +L+ A                   QK    +KL   + +  Q L  E E++  +  N + 
Sbjct: 981  ELKIA-----------------VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE- 1022

Query: 1869 ELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQ 1928
                S+E  +QL+S+   +  + L        T Q+  S++ +    Q++      ++  
Sbjct: 1023 ---KSQETFKQLQSDFYGRESELL-------ATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072

Query: 1929 MNSLEQELETIH--LENEGLKKKQVKLDEQLMEMQHLR 1964
             N L QEL+T    LE +  KK+Q +L E+   +Q ++
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQ-QLQERCKALQDIQ 1109



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 170/779 (21%), Positives = 319/779 (40%), Gaps = 149/779 (19%)

Query: 1280 NKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENE--ELNVLVLR-----LQGKI 1332
            N E ++E F     +K +    E F   E  +D         E N+ + R     L+ ++
Sbjct: 33   NNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEV 92

Query: 1333 EKLQESVVQRCDCCLWEAS-----------LENLEIEPDGNILQLNQTLEECVPRVRSVH 1381
            + LQ S+ +      W +            L+  E +PDG +   +  L+       S+ 
Sbjct: 93   QDLQASLKEE----KWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQ-------SLE 141

Query: 1382 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQ 1441
              +EE + EN  ++    L E+ KA ++A     I++  +  R   +   ++ T L    
Sbjct: 142  QQLEEAQTENFNIKQMKDLFEQ-KAAQLATEIADIKSKYDEERSLREAAEQKVTRLT--- 197

Query: 1442 DKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQIT 1501
                       EL  E T +Q+L  +L +R  I    +DV    ++  +++ +M ++ + 
Sbjct: 198  ----------EELNKEATVIQDLKTELLQRPGI----EDVAVLKKELVQVQTLMDNMTL- 242

Query: 1502 CSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETV 1561
              E +++ E L+ E +KLQ + +         + E +IS L+     G QE         
Sbjct: 243  --ERERESEKLKDECKKLQSQYA---------SSEATISQLRSELAKGPQE--------- 282

Query: 1562 KQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQK 1621
                  V   V+ L+K  S +            EL+QKN           Q LTE L +K
Sbjct: 283  ------VAVYVQELQKLKSSVN-----------ELTQKN-----------QTLTENLLKK 314

Query: 1622 EKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD 1681
            E++   + LEE+  E+   K+ ++    Q       L++ LS  +   H +  E     +
Sbjct: 315  EQD--YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372

Query: 1682 ELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSE---ELNSCVDKLAKSSLLEH 1738
              +K+K+     +LS+ + K   + +  ++L +++E   +   +L S +++L  S LLE 
Sbjct: 373  ATQKLKE-----ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL-HSKLLE- 425

Query: 1739 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLR--VTQ--- 1793
                    ++        LK Q   S EK+ + E  V ++ L++SR++  L+  VT    
Sbjct: 426  -------TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478

Query: 1794 ------------QEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKL 1841
                        QE++AL+Q   +  ++ QN   +    +I      + N +  L   K 
Sbjct: 479  LQHQLDKTKQQHQEQQALQQSTTAKLREAQN-DLEQVLRQIGDKDQKIQNLEALLQKSK- 536

Query: 1842 DHLMNEEQQLLWQENERLQTMVQNTKAE---LTHSREKVRQLESNLLPKHQKHLNPSGTM 1898
                 E   LL +E E L   +Q  + E   L   +EK   L+  +    +K  N S   
Sbjct: 537  -----ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS--- 588

Query: 1899 NPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLM 1958
               E  K + +   DQ Q++++       ++ SLE  +  ++ +    K+K  +LD Q+ 
Sbjct: 589  ---ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645

Query: 1959 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELEN 2017
                L  +A  + +    DLQ     A   +  +Q  +L +   Q +++   LQ++ E+
Sbjct: 646  AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ-QELNKITTQLDQVTAKLQDKQEH 703


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score =  167 bits (423), Expect = 1e-40
 Identities = 345/1694 (20%), Positives = 696/1694 (41%), Gaps = 259/1694 (15%)

Query: 369  IRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKE 428
            + H  ER+    RE + LR +L+K      L A    +    I +     ++      KE
Sbjct: 61   LSHSQERLVNETRECQSLRLELEKLNN--QLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118

Query: 429  RIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKE------NSR 482
             + A K +L +  E++ Q+      ++++  EK K E N  +  L L L E      + +
Sbjct: 119  ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK-ESNTTKGELQLKLDELQASDVSVK 177

Query: 483  LENELLENAEKLAEYEN--LTNKLQRNLENVLA---EKFGDLDPSSAEFFLQEE---RLT 534
               + LE  ++L   +N  L  +L+   + +LA   EK  ++         ++E   RL 
Sbjct: 178  YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE 237

Query: 535  QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKN-------------SPSEEVE 581
            +  N  +     LQ  V++L ++L+E + Q   +     N             S +++ E
Sbjct: 238  EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297

Query: 582  ANSG----GIEPEHGLGSEECNPLNMSIEAELV-IEQMKEQHHRDICCLRLELEDKVRHY 636
            A S      +E  H L  +E    N +I+  L+ +EQ K+Q  +       E+ +K+   
Sbjct: 298  AKSNELTRAVEELHKL-LKEAGEANKAIQDHLLEVEQSKDQMEK-------EMLEKIGRL 349

Query: 637  EKQLDETVVSCKKAQENMKQRHENETHTLEK-------------QISDLKNEIAELQGQA 683
            EK+L+         +       E E   +               ++++L N   E Q Q 
Sbjct: 350  EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL 409

Query: 684  AVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEM-ELKARLTQAQASFERER 742
             + K  +       +E  K+++ K    K   +E  R Q  +  L  +L QA    +R +
Sbjct: 410  LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQ 469

Query: 743  EGL-----QSSAWTEE-------------KVRGLTQELEQ------FHQEQLTS------ 772
            E       QSS    +             ++R L  ELE+         E+++S      
Sbjct: 470  EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529

Query: 773  --LVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTE--- 827
              ++ +H +    + +EL +++QR L   RE  ET    R  Q     ++   K+TE   
Sbjct: 530  SEVISQHLVSYRNI-EELQQQNQRLLVALRELGETR--EREEQ-----ETTSSKITELQL 581

Query: 828  RCESALQSLEG--RYRQELKDLQEQQREEKSQWEFEKDELTQECA--EAQEL----LKET 879
            + ESAL  LE   + RQ    L +    ++  +     + T       A  L    L  T
Sbjct: 582  KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641

Query: 880  LKREKTTSLVLTQER-EMLEKTYKEHLNSMVVERQQLLQDLE----DLRNVSETQQSLLS 934
             KR  T+  V T     ++E T      + + + Q++ ++ +    +   +   Q   L 
Sbjct: 642  PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701

Query: 935  DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 994
            +Q+ +L+S + +   + +            AS+R E L+   +  R+E+ S     E   
Sbjct: 702  EQVTDLRSQNTKISTQLD-----------FASKRYEMLQDNVEGYRREITS---LHERNQ 747

Query: 995  KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGDGALSLL 1053
            K T  T  +E+         + +  ++++ A   L++ +   + + +E E+     + L 
Sbjct: 748  KLTATTQKQEQI--------INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLS 799

Query: 1054 QQGEQLL-EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV-MSSCLDEP 1111
            QQ E LL E+ G  LL       Q + E  +  T+  RL  +++KLE  +  +   L+  
Sbjct: 800  QQRESLLAEQRGQNLLLTNLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858

Query: 1112 ATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHV-LSDLEDDEVRDLGSTGTSSVQRQEVKI 1170
              +    T       L   R  Q++  T  H+   +L  +  +++ +T    +   EV++
Sbjct: 859  VEQRHTLTRNLDVQLLDTKR--QLDTETNLHLNTKELLKNAQKEI-ATLKQHLSNMEVQV 915

Query: 1171 EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSV 1230
                +   G  +  N E+      +L +Q+ Q +EQ+          ++ K+ L    S 
Sbjct: 916  ASQSSQRTGKGQPSNKEDVD----DLVSQLRQTEEQV----------NDLKERLKTSTSN 961

Query: 1231 LKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRL 1290
            +++   M+  + E+  K K + E+V +  +   +E    +T+ ++ L    E+  E   L
Sbjct: 962  VEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL---MEVEKEKQEL 1018

Query: 1291 QDELKKMEEVTETFLS-LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1349
            QD+ ++  E  E  LS L+K+   V+ E +E            ++ +    ++    +  
Sbjct: 1019 QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078

Query: 1350 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1409
             +    E+      ++  Q  +E V ++ SV   +EE  Q+ +     +QLLE     + 
Sbjct: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE-----SQLLEC----KA 1129

Query: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1469
            +W        +ER R+               +D+  +      +LE +   L +   KL 
Sbjct: 1130 SW--------EERERM--------------LKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167

Query: 1470 ERVTILVKQK-------DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQE 1522
            ++V   VK+         +   G+ +E++  ++  ++      + + E+ + ES + +Q 
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQR 1227

Query: 1523 NSILRNEITTLNEEDSISNLKL---GTLNGSQEEMWQKTET---VKQENAAVQKMVENLK 1576
              +L  E+  L +  +    K+          EE+ +KTET   V + N  +++  E L+
Sbjct: 1228 VELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLE 1287

Query: 1577 KQISELKIKNQQLDLE-------NTELSQKNS--QNQEKLQE--------LNQRLTEMLC 1619
            + + +++ K ++L+L+       N ELS+K+   Q ++KL E         NQ L     
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK 1347

Query: 1620 QKEKEPGNSALEERE----------QEKFNLKEELERCKVQ---SSTLVSSLEAELSEVK 1666
              + E     L E+E          +E   LK E+ R       +  L+ SL+ +L++V+
Sbjct: 1348 DPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVR 1407

Query: 1667 IQTHIVQQE-NHLLKDELEKMKQLHRCPDLSD-FQQKISSVLSYNEKLLKEKEALSEELN 1724
             +   +Q++ +  + D  EK+K + +   +   ++ +   + +  +K+++     S +  
Sbjct: 1408 TEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQ 1467

Query: 1725 SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSR 1784
                 + +   L+  +   + + KS E Q  +L+  L   + + +NL++    +  ++SR
Sbjct: 1468 EQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNA--GGKSWAPEIATHPSGLHNQQKRLSWDKLD 1842
            ++ DL+    ++E L+Q++    ++ + A    KS   +IA H +G+ +Q       K +
Sbjct: 1528 LRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS---KIA-HLAGVKDQ-----LTKEN 1578

Query: 1843 HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL-------NPS 1895
              + +    L Q+ + L   +   K++      ++ +LE  L    ++HL        PS
Sbjct: 1579 EELKQRNGALDQQKDELDVRITALKSQY---EGRISRLERELREHQERHLEQRDEPQEPS 1635

Query: 1896 GTMNPTEQEKLSLK 1909
              + P +Q +++LK
Sbjct: 1636 NKV-PEQQRQITLK 1648



 Score =  145 bits (367), Expect = 3e-34
 Identities = 311/1592 (19%), Positives = 656/1592 (41%), Gaps = 260/1592 (16%)

Query: 626  RLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 685
            R EL    +  + +L++ +   +   + +K RHE      E+Q  +++  ++    Q  +
Sbjct: 11   RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS--HSQERL 68

Query: 686  LKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGL 745
            + E     + R E EK   Q+K   EK + + ++     + ++++ T+ +   E E+  L
Sbjct: 69   VNETRECQSLRLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127

Query: 746  --------QSSAWTEEKVRGLTQELEQ-----------FHQEQLTSLVEKHTLEKEELRK 786
                    Q   +  E V+ L ++L++             + Q + +  K+  ++ E  K
Sbjct: 128  IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187

Query: 787  ELLEKHQREL----------------QEGREKMETECN-----RRTSQIEAQF------Q 819
            ELL      L                ++G E +E +CN        S++E Q        
Sbjct: 188  ELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSN 247

Query: 820  SDCQKVTERCESALQ-------SLEGRYRQELK---DLQEQQREEKSQWEFEKDELTQEC 869
               QK  E   + L+       S+E ++  EL     L    +      E + +ELT+  
Sbjct: 248  EHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAV 307

Query: 870  AEAQELLKETLKREKTTSLVLTQ--------EREMLEKTYK-----EHLNSMV--VERQQ 914
             E  +LLKE  +  K     L +        E+EMLEK  +     E+ N ++   +R+ 
Sbjct: 308  EELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKG 367

Query: 915  LLQDLEDLRNVSETQQSL-------------------LSDQILELKSSHKRELREREEVL 955
             +   E+L  +S T  ++                     DQ+L  K  +KR  +  +E++
Sbjct: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427

Query: 956  CQAGASEQLASQRLERLEMEHDQERQEMMSKLL--AMENIHKATCET--ADRERAEMSTE 1011
             +  A   +  +  +R E E  Q+    +S  L  AM+ I +   +T  A+++ + +  +
Sbjct: 428  KEVEAKAPILKR--QREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERD 485

Query: 1012 ISRLQSKIKEMQQATSPLSM---LQSGCQVIGEEEVEG---DGALSLLQQG-------EQ 1058
              R++ ++K++ Q    L M      G  VI +EEV       +  ++ Q        E+
Sbjct: 486  NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE 545

Query: 1059 LLEENGDVLLSLQRAHEQAVKENVK-MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFG 1117
            L ++N  +L++L+   E   +E  +  +++I+ LQ +L+     L       +   +   
Sbjct: 546  LQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVD 605

Query: 1118 NTAEQTEPF-LQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEAS 1176
            +   Q + + +  ++T  V        L D+         ST  +      V + ES  +
Sbjct: 606  SIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665

Query: 1177 VEGFSEL-------ENSEETRTESWELKN-QISQLQEQLMMLCADCDRASEKKQDLLFDV 1228
            +E  + L       EN ++ + E+ +++N Q+ +LQEQ+  L     R+   K     D 
Sbjct: 666  IEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDL-----RSQNTKISTQLDF 720

Query: 1229 SVLKKKLKML-ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV 1287
            +   K+ +ML + +     +   L+E   +     Q++ +++ T   +    N++L    
Sbjct: 721  A--SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778

Query: 1288 FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL---QGKIEKLQESVVQRCD 1344
             R ++  K+ E +  + + L +  + +  E    N+L+  L   QG +E+ +    QR  
Sbjct: 779  VRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRL- 837

Query: 1345 CCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE---NQYLEGNTQLL 1401
                 + +E LE E      +L   +E+     R++   + + K++      L  NT+ L
Sbjct: 838  ----SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKEL 893

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             K    EIA    T++ H     VQ   +  +++   G       ++  + +L  +  + 
Sbjct: 894  LKNAQKEIA----TLKQHLSNMEVQ---VASQSSQRTGKGQP--SNKEDVDDLVSQLRQT 944

Query: 1462 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1521
            +E    LKER+          +     E+ +AM+  L+ + ++ +Q  E +R   E   +
Sbjct: 945  EEQVNDLKERLK---------TSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK 995

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
            E++  + ++     E      +L      Q++  +  E+++Q+ + ++K + +++ ++ E
Sbjct: 996  ESAEFQTQLEKKLMEVEKEKQEL------QDDKRRAIESMEQQLSELKKTLSSVQNEVQE 1049

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKL--QELNQRLTEMLCQKEKEPGNSALEEREQEKFN 1639
              ++     L N + ++++ Q Q K+  +  N+   E++          A +E+  +  +
Sbjct: 1050 -ALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMAS 1108

Query: 1640 LKEELE-----------RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKM-- 1686
            +++ LE            CK         L+ E+S+   +   ++++N LL D++EK+  
Sbjct: 1109 VRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD 1168

Query: 1687 ------KQLHRCP---DLSD---FQQKISSVLSY--NEKLLKEK---------------- 1716
                  K+  + P    LS+    Q++I  +L +   EK + E                 
Sbjct: 1169 KVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRV 1228

Query: 1717 EALSEELNSCVDKL-AKSSLLEHRIATMKQEQ---KSWEHQSASLKSQLVASQEKVQNLE 1772
            E L  EL    D L A+   ++    TM Q +   K  E  +  +++  +  +EK + LE
Sbjct: 1229 ELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEK-ERLE 1287

Query: 1773 DTVQNVNLQMSRMKSDLRVTQQEKEAL--KQEVMSLHKQLQNAGGKSWAPEIATHPSGLH 1830
              +Q +  ++ +++ D+   Q+    L  K  ++   K+L     K W          L 
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRW----KARNQHLV 1343

Query: 1831 NQQKRLSWDKLDHLMNEEQ------QLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1884
            +QQK    ++   L++E++      Q L +E  RL+  +  + A LT+++  ++ L+ +L
Sbjct: 1344 SQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDL 1403

Query: 1885 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE 1944
                          N    EK +++++ D    +     + ++Q+  + +  +T   + E
Sbjct: 1404 --------------NKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKT---QYE 1446

Query: 1945 GLKKKQVKLDE--------------QLMEMQHLRSTATPSPS-PHAWDLQLLQQQACPMV 1989
             LK +Q K+ E               + EMQ L+ T   + +   + + Q+   Q     
Sbjct: 1447 ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506

Query: 1990 PREQFLQLQRQLLQAERINQHLQEELENRTSE 2021
               +   LQ Q +Q +     L+++L++RT++
Sbjct: 1507 KETEARNLQEQTVQLQSELSRLRQDLQDRTTQ 1538



 Score =  116 bits (291), Expect = 2e-25
 Identities = 217/1055 (20%), Positives = 461/1055 (43%), Gaps = 169/1055 (16%)

Query: 307  VERILDTWQEEGIEN----SQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAAL 362
            ++ I + +++E  EN    ++++ K  +   D     T+++  L+      +  + Q  +
Sbjct: 675  LQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLD--FASKRYEMLQDNV 732

Query: 363  ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV---DDHHAAIERRNEYNL 419
              ++ EI  L ER        +KL +   K E++ + M  ++   ++  A  E R E NL
Sbjct: 733  EGYRREITSLHER-------NQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAE-NL 784

Query: 420  RKLDEEYKERIAALKNELRKEREQILQQAGKQRLEL------EQEIEKAKTEENYIRDRL 473
            +K     KE +   +  L ++RE +L +   Q L L      +  +E+++TE    + RL
Sbjct: 785  KK----EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET---KQRL 837

Query: 474  ALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL 533
            +  ++   +LE+E+    +KL       + L RNL+  L +    LD  +      +E L
Sbjct: 838  SSQIE---KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894

Query: 534  TQMRNEYERQCRVL----------------------QDQVDELQSELEEYRAQGRVLRLP 571
               + E     + L                      ++ VD+L S+L +   Q   L+  
Sbjct: 895  KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER 954

Query: 572  LKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELED 631
            LK S S   +  +     E  L  E+               Q+ E+  ++I    + L++
Sbjct: 955  LKTSTSNVEQYQAMVTSLEESLNKEK---------------QVTEEVRKNI---EVRLKE 996

Query: 632  KVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHH 691
                ++ QL++ ++  +K ++ ++        ++E+Q+S+LK  ++ +Q +   ++EA  
Sbjct: 997  SAE-FQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE---VQEALQ 1052

Query: 692  EATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT 751
             A+     E++  +   E+ K  ++ + + + E+ L A   +A    +  +E +   A  
Sbjct: 1053 RASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEA---LQAAKEQVSKMASV 1109

Query: 752  EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRK-----ELLEKHQRELQEGREKMETE 806
             + +   TQ+ E    E   S  E+  + K+E+ K     E LEK  R L +  EK+   
Sbjct: 1110 RQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS-- 1167

Query: 807  CNRRTSQIEAQFQSDCQ-KVTERCESALQSLE-GRYRQELKDLQEQQRE----EKSQWEF 860
             ++  + ++   Q      ++E  +S  Q LE  R+ +  K++ E + E    E  ++  
Sbjct: 1168 -DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226

Query: 861  EKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHL----NSMV-VERQQL 915
              + L +E  E Q+ L    ++ + T+  + Q  E+++KT   ++    N M+  E+++L
Sbjct: 1227 RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERL 1286

Query: 916  LQDLEDLR-NVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM 974
             QDL+ ++  V + +  +L  Q    + S K  + + E+ L +       A  R + L  
Sbjct: 1287 EQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKA--RNQHLVS 1344

Query: 975  EHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1034
            +      E   KLL+ + +H    +       +++ EI RL++   E+ ++ + L+  Q+
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQ-------QLTEEIGRLKA---EIARSNASLTNNQN 1394

Query: 1035 GCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR 1094
              Q + E+       L+ ++  ++ ++++ D  +         ++E VK  T++ ++ +R
Sbjct: 1395 LIQSLKED-------LNKVRTEKETIQKDLDAKII-------DIQEKVKTITQVKKIGRR 1440

Query: 1095 LQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRD 1154
             +                T++    A+Q +       + Q  G  +   +S  E  E+++
Sbjct: 1441 YK----------------TQYEELKAQQDK---VMETSAQSSGDHQEQHVSVQEMQELKE 1481

Query: 1155 LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADC 1214
                   ++ + E K +  E+ VE   +  + +E  TE+  L+ Q  QLQ +L  L  D 
Sbjct: 1482 -------TLNQAETKSKSLESQVENLQKTLSEKE--TEARNLQEQTVQLQSELSRLRQDL 1532

Query: 1215 -DRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLL---YEDVSRENDCLQEELRMME 1270
             DR ++++Q       + +K+ K  + I  A  K   L    + +++EN+ L++    ++
Sbjct: 1533 QDRTTQEEQ---LRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589

Query: 1271 TRYDE------ALENNKELTAEVFRLQDELKKMEE 1299
             + DE      AL++  E    + RL+ EL++ +E
Sbjct: 1590 QQKDELDVRITALKSQYE--GRISRLERELREHQE 1622



 Score =  102 bits (254), Expect = 4e-21
 Identities = 148/700 (21%), Positives = 295/700 (42%), Gaps = 86/700 (12%)

Query: 1388 KQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQ----ERPRVQNQV--ILEENTTLLGFQ 1441
            + E QY E     +EK  +H    L    +  Q    E  ++ NQ+  + E+N  L   Q
Sbjct: 49   ESEQQYFE-----IEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQ 103

Query: 1442 DKHFQHQA----TIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
            D++   Q+    T  ELE EK  L     +L + +  L +  DV    EK +E      +
Sbjct: 104  DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTE--DVKRLNEKLKESNTTKGE 161

Query: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE----------------DSISN 1541
            LQ+   E+Q     ++Y  ++L+QE  +L ++ T LN E                + I  
Sbjct: 162  LQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE 221

Query: 1542 LKLGTLNGSQE--EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE------- 1592
            LK    N  +E   + ++   +K  N  +QK VE+L  ++ E   K QQ  +E       
Sbjct: 222  LKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKE--AKEQQASMEEKFHNEL 279

Query: 1593 NTELSQKN------SQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQEKFNLKEELE 1645
            N  +   N        ++ K  EL + + E+    KE    N A+++   E    K+++E
Sbjct: 280  NAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQME 339

Query: 1646 RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLL-KDELEKMKQLHRC------PDLSDF 1698
            +  ++    +  LE EL          +++  +L ++EL  M            P +   
Sbjct: 340  KEMLEK---IGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLT 396

Query: 1699 QQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQS---A 1755
            +   + V + ++ LL++ E  ++ +N  +D++ K   +E +   +K++++ +E      A
Sbjct: 397  ELYNAYVETQDQLLLEKLE--NKRINKYLDEIVKE--VEAKAPILKRQREEYERAQKAVA 452

Query: 1756 SLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGG 1815
            SL  +L  + +++Q L++     N Q S ++ D R  + + + L Q++  L  +L+ A G
Sbjct: 453  SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512

Query: 1816 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1875
                 +     + + +  + +S   + +   EE Q   Q+N+RL   ++    EL  +RE
Sbjct: 513  NHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQ---QQNQRLLVALR----ELGETRE 565

Query: 1876 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE---CDQFQKEQSPANRKVSQMNSL 1932
            +  Q E+      +  L     +   EQ + S + +    D   +++      +SQ   +
Sbjct: 566  REEQ-ETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV 624

Query: 1933 EQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPRE 1992
               L    L++       V L          ++ +TP+P P     + ++ +A     +E
Sbjct: 625  AIPLHASSLDD-------VSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQE 677

Query: 1993 QFLQLQRQLLQAERINQHLQEELENRTSETNTPQALLPEQ 2032
             F   +++  + E+I     E+L+ + ++  +    +  Q
Sbjct: 678  IFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQ 717



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 198/989 (20%), Positives = 389/989 (39%), Gaps = 139/989 (14%)

Query: 1151 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLM 1208
            E  +L     S   + E  + + ++ ++G        +  +E   +E++ ++S  QE+L+
Sbjct: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69

Query: 1209 MLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRM 1268
                +C     + + L   +  L +K K LE   + +   +  +     E +  + +L  
Sbjct: 70   NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129

Query: 1269 METRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1328
               R  + LE    LT +V RL ++LK   E   T   L+   DE++  +  +     RL
Sbjct: 130  TNERLSQELE---YLTEDVKRLNEKLK---ESNTTKGELQLKLDELQASDVSVKYREKRL 183

Query: 1329 QGKIEKL-QESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEEC 1387
            + + E L  ++     +       L  L  E    IL+L   LE     V  +   +   
Sbjct: 184  EQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGL 243

Query: 1388 KQENQYLEGNTQ-LLEKVK------------------AH-EIAWLHGTIQTHQERPRVQN 1427
            K  N++L+ + + LL K+K                  AH +++ L+ +     E    + 
Sbjct: 244  KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303

Query: 1428 QVILEENTTLL---GFQDKHFQHQATIAEL---ELEKTKLQELTRKLKERVTILVKQKDV 1481
               +EE   LL   G  +K  Q      E    ++EK  L+++ R  KE    L    D+
Sbjct: 304  TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE----LENANDL 359

Query: 1482 LSHGEK------EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT--- 1532
            LS  ++      EEEL AM          ++  ++L    +  ++ ++ +L  ++     
Sbjct: 360  LSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI 419

Query: 1533 ---LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
               L+E       K   L   +EE     E  ++  A++   +E   K+I  L+    + 
Sbjct: 420  NKYLDEIVKEVEAKAPILKRQREEY----ERAQKAVASLSVKLEQAMKEIQRLQEDTDKA 475

Query: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649
            + +++ L + N + + ++++L+Q++  +L + E+  GN  + + E    ++    E   V
Sbjct: 476  NKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE---V 532

Query: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1709
             S  LVS    E  + + Q  +V      L +  E+ +Q      +++ Q K+ S L+  
Sbjct: 533  ISQHLVSYRNIEELQQQNQRLLVALRE--LGETREREEQETTSSKITELQLKLESALTEL 590

Query: 1710 EKLLKEKEALSEELNSCVDK-----------------LAKSSLLEHRIAT---------- 1742
            E+L K ++   + ++S V +                 L  SSL +  +A+          
Sbjct: 591  EQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQT 650

Query: 1743 ---------------------MKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQ 1781
                                 +KQ Q+ +E+             E+++ L++ V ++  Q
Sbjct: 651  VSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQ 710

Query: 1782 MSRMKSDL-------RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPE--IATHPSGLHNQ 1832
             +++ + L        + Q   E  ++E+ SLH++ Q     +   E  I T    L   
Sbjct: 711  NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGA 770

Query: 1833 QKRLSWDKL--DHLMNEEQQL------LWQENERLQTMVQNTKAELTHSREKVRQLESNL 1884
             ++L+  ++  ++L  E++ L      L Q+ E L    +     LT+ +     LE + 
Sbjct: 771  NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSE 830

Query: 1885 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVS-QMNSLEQELET---IH 1940
                Q+    S  +   E E   LK++ +   +++    R +  Q+   +++L+T   +H
Sbjct: 831  TETKQR---LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLH 887

Query: 1941 LENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQ 2000
            L  + L K   K  E     QHL +      S  +      Q        +E    L  Q
Sbjct: 888  LNTKELLKNAQK--EIATLKQHLSNMEVQVASQSSQRTGKGQPS-----NKEDVDDLVSQ 940

Query: 2001 LLQAERINQHLQEELENRTSETNTPQALL 2029
            L Q E     L+E L+  TS     QA++
Sbjct: 941  LRQTEEQVNDLKERLKTSTSNVEQYQAMV 969



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 38/152 (25%)

Query: 316  EEGIENSQEILKALDFSLDGNINLTELTLALENEL--------------------LVTKN 355
            E  +EN Q+ L   +       NL E T+ L++EL                    +  K 
Sbjct: 1494 ESQVENLQKTLSEKETEAR---NLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE 1550

Query: 356  SIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRN 415
               + A+ + K++I HL    DQ+ +E E+L+      ++ K  +               
Sbjct: 1551 EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDEL--------------- 1595

Query: 416  EYNLRKLDEEYKERIAALKNELRKEREQILQQ 447
            +  +  L  +Y+ RI+ L+ ELR+ +E+ L+Q
Sbjct: 1596 DVRITALKSQYEGRISRLERELREHQERHLEQ 1627


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  163 bits (412), Expect = 2e-39
 Identities = 378/1794 (21%), Positives = 731/1794 (40%), Gaps = 293/1794 (16%)

Query: 326  LKALDFSLDG-NINLTELTLALEN-ELLVTKNSIHQAALASFKAEIRHLLERVDQVVREK 383
            L+  + SLD  N  L +L   L N EL + ++   +  L      IR  LE  +    + 
Sbjct: 1196 LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQS 1255

Query: 384  EKLRS----DLDKAEKLKS----LMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKN 435
            +++      ++D  EK  S    L  S+ D+ H     +   N     E+  E + A K 
Sbjct: 1256 QEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKY 1315

Query: 436  ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLA 495
            EL  E      +      ++ +E+ K   E   + D       ++  L  EL+E+     
Sbjct: 1316 ELVTELNDSRSECITATRKMAEEVGKLLNEVKILND-------DSGLLHGELVEDIPG-G 1367

Query: 496  EYENLTNKLQRNLENVLAEK--FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQ--- 550
            E+    N+        L E   +  L  S  E  +    L +     + + ++L DQ   
Sbjct: 1368 EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQ 1427

Query: 551  ----VDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG---SEECNPLNM 603
                + ELQ+ ++  +A+  VL   L+N   + V+    G+  E GL    S  C P + 
Sbjct: 1428 MSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL--EEGLVPSLSSSCVPDSS 1485

Query: 604  SIEA-------ELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 656
            S+ +         ++EQ  +        L   LE  V   +  +DE  V C   QE    
Sbjct: 1486 SLSSLGDSSFYRALLEQTGDM------SLLSNLEGAVSANQCSVDE--VFCSSLQEENLT 1537

Query: 657  RHENET-----------------HTLEKQISDLKNE----IAELQGQAAVLKEAHHEATC 695
            R E  +                  +LEK    ++++      E+Q    +L     E  C
Sbjct: 1538 RKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDC 1597

Query: 696  RHEE---EKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW-- 750
              ++   E +Q Q KL      ++ KL  + +   +  L    A  + +   L S +   
Sbjct: 1598 LRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLG 1657

Query: 751  --TEEKVRGLTQ--ELEQFHQEQLTSLVEKHTLEK---EELRKELLEKHQRELQEGREKM 803
              TE+ ++G  +  ++ + H  + T    KH + +   ++ +++L    ++  + G  K 
Sbjct: 1658 IDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKP 1717

Query: 804  ETECNRRTS---------QIEAQFQSDC----------------------------QKVT 826
              EC+   S         + + Q  S+C                             +V 
Sbjct: 1718 TGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK 1777

Query: 827  ERCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDEL---TQECAEAQELLKETL 880
            E     L+ L   E R R +++ L  + +E  S+   ++ +L    + C E ++++ E L
Sbjct: 1778 ETSNENLRLLHVIEDRDR-KVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGE-L 1835

Query: 881  KREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILEL 940
            K+E +    L+++ E     ++E L   V   + L  DLE   +  ++ +  + D + ++
Sbjct: 1836 KKENSD---LSEKLEYFSCDHQE-LLQRVETSEGLNSDLE--MHADKSSREDIGDNVAKV 1889

Query: 941  KSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHK-ATCE 999
              S K    + E  L +  + +  AS   E L +E D E  +     L  +N +K     
Sbjct: 1890 NDSWKERFLDVENELSRIRSEK--ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV 1947

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGDGALSLLQQGEQ 1058
              + E + +++E ++L+ ++  M + T+ L  L    +   +E E      L  +Q  E 
Sbjct: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA 2007

Query: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
             ++E  ++L +L       V E +K  T +    Q L+K    L ++ C           
Sbjct: 2008 EVKEKTELLQTL----SSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC----------- 2052

Query: 1119 TAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVE 1178
              E      Q N+ K++       + + L + +   L      S   +   +E+ E ++ 
Sbjct: 2053 --ELENQIAQLNKEKELLVKESESLQARLSESDYEKL----NVSKALEAALVEKGEFALR 2106

Query: 1179 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFD-VSVLKKKLKM 1237
              S  E   + R    +L+ +I +  E+  +  A+  +  E++ D L D V  L+++L+M
Sbjct: 2107 LSSTQEEVHQLRRGIEKLRVRI-EADEKKQLHIAEKLKERERENDSLKDKVENLERELQM 2165

Query: 1238 LERIPEA----SPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDE 1293
             E   E     +   K   E +  + + +   L++ E          + LT ++   Q +
Sbjct: 2166 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ 2225

Query: 1294 LKKMEEVTETFLSL--EKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRC-DCCLWEA 1350
            L +++++  +F SL  EK   E++I+ EE    V  LQ ++++L E+V   C D  + +A
Sbjct: 2226 LSELDKLLSSFKSLLEEKEQAEIQIK-EESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284

Query: 1351 SLENLE--IEPD----GNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1404
            + ++L+  IE +     +I +L   LE    +   V   ++E +     L+G  + LE  
Sbjct: 2285 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE-- 2342

Query: 1405 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQEL 1464
            +  EIA      +T+QE   ++      EN+                 E+E  K K++ +
Sbjct: 2343 RELEIA------RTNQEHAALE-----AENSK---------------GEVETLKAKIEGM 2376

Query: 1465 TRKLK----ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1520
            T+ L+    + VTI  +++++ +  +KE+E    + +L+I  S  +  ++    E  +++
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQE---RISELEIINSSFENILQEKEQEKVQMK 2433

Query: 1521 QENS----ILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1576
            +++S    +L+ ++  LNE       ++  L+  QE              A +   +NL 
Sbjct: 2434 EKSSTAMEMLQTQLKELNE-------RVAALHNDQE--------------ACKAKEQNLS 2472

Query: 1577 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQE 1636
             Q+       + L+LE  +L Q   + +     L   +  ++  +E E G   LE++++E
Sbjct: 2473 SQV-------ECLELEKAQLLQGLDEAKNNYIVLQSSVNGLI--QEVEDGKQKLEKKDEE 2523

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD---ELEKMKQLHRCP 1693
               LK +++        LVS    +LS+V+ +  + +++N  L++   ELE+  Q+ +  
Sbjct: 2524 ISRLKNQIQ----DQEQLVS----KLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSK 2575

Query: 1694 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1753
            + S  Q  +  + S  + L  E E    +  S V+K+ K +  E     +++E      +
Sbjct: 2576 NAS-LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE---TELQREMHEMAQK 2631

Query: 1754 SASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1813
            +A L+ +L  S EK   L   +Q +  ++   K  L+    E   LK+ +  +HK     
Sbjct: 2632 TAELQEEL--SGEK-NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEK 2688

Query: 1814 GGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1873
             GK    EIA +   LH  +K+             Q LL   N++ +  +Q  + +LT  
Sbjct: 2689 EGKV-REEIAEYQLRLHEAEKK------------HQALLLDTNKQYEVEIQTYREKLTSK 2735

Query: 1874 RE--KVRQLESNLLPKHQKHLNPS-----GTMNPTEQEKLSLKRECDQFQKEQSPANRK- 1925
             E    ++LE +LL   ++ LN S       +   ++ K+   +  +Q +KE   A  K 
Sbjct: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795

Query: 1926 ---VSQMNSLEQELETIHLENEGLKKKQ----------VKLDEQLMEMQHLRST 1966
               +     LE+E E +  E   L+  Q           K+DE   E++ L+ T
Sbjct: 2796 KLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKET 2849



 Score =  144 bits (363), Expect = 9e-34
 Identities = 380/1895 (20%), Positives = 758/1895 (40%), Gaps = 270/1895 (14%)

Query: 311  LDTWQEEGIENSQEILKALDFSLDGNINLT----ELTLALENELLVTKNSIHQAA----- 361
            L+  +E   +  QE L  L F+ + N NL      +  AL +E+   +N+    A     
Sbjct: 1071 LEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130

Query: 362  -LASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIE-RRNEYNL 419
             + + K E   + + V+ +++E E+L   +    + ++L +  + +     E  RN+ N 
Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNF 1190

Query: 420  R-KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS-L 477
            + ++D E KE      N    + E +L+    +  E E+E E  + E   IR  L  S L
Sbjct: 1191 KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNL 1250

Query: 478  KENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR 537
            ++    E   L++ E  AE + ++             +       +A      +      
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGP----------HELSTSQNDNAHLQCSLQTTMNKL 1300

Query: 538  NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEE 597
            NE E+ C +LQ +  EL +EL + R++     +      +EEV    G +  E  + +++
Sbjct: 1301 NELEKICEILQAEKYELVTELNDSRSEC----ITATRKMAEEV----GKLLNEVKILNDD 1352

Query: 598  CNPLNMSIEAEL----VIEQMKEQHHRDICCL-------RLELEDK-VRHYEKQLDETVV 645
               L+  +  ++      EQ  EQH   +  L        L L DK V+ +  +L E  +
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFL 1412

Query: 646  SCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
            S +   + +  +H      +  ++S+L+  +  L+ +  VL            +  K++Q
Sbjct: 1413 SLQSEHKILHDQHCQ----MSSKMSELQTYVDSLKAENLVLSTNLRNF---QGDLVKEMQ 1465

Query: 706  VKLEE---------------------EKTHLQEKLRLQHEMELKARLTQAQASFEREREG 744
            + LEE                     + +  +  L    +M L + L  A ++ +   + 
Sbjct: 1466 LGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDE 1525

Query: 745  LQSSAWTEEKV-RGLTQELEQFHQEQLTSLVE--KHTLEKEELRKE----LLEKHQRELQ 797
            +  S+  EE + R  T        E+L SL E  + +LEK E + E    +  K  +EL+
Sbjct: 1526 VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE 1585

Query: 798  E--GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE-E 854
            +    E+ E +C R+      Q+ S+ ++  ++  S    +E +   E K  ++   E E
Sbjct: 1586 QLLSSERQELDCLRK------QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELE 1639

Query: 855  KSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQ 914
             ++ + +  +L+       +       R ++  +      E  E+T K  ++ +  +  Q
Sbjct: 1640 VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQ 1699

Query: 915  LLQDLE-DLRNVSETQQSLLSDQILELKSSHKR-------ELREREEVLCQAGASEQLAS 966
              QDL  D+  ++ET     + +    +S           + +   E + +   S   A 
Sbjct: 1700 --QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNAL 1757

Query: 967  QRLERLEMEHDQERQEMMSKLLAMENIHKA-TCETADRERAEMSTEISRLQSKI--KEMQ 1023
              ++ L  + D    ++  K  + EN+      E  DR+   +  E+  L SK+  +E+Q
Sbjct: 1758 VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQ 1817

Query: 1024 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQ----QGEQLLEE-------NGDVLLSLQR 1072
              T   + ++   +++GE + E       L+      ++LL+        N D+ +   +
Sbjct: 1818 LMTKIEACIELE-KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876

Query: 1073 AHEQAVKENVK------------MATEISRLQQRLQKLE-PGLVMSSCLDEPATEFFGNT 1119
            +  + + +NV             +  E+SR++     +E   L + + L+   TE     
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-- 1934

Query: 1120 AEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG 1179
                    + N  KQ   V     LS +  +  +  G   T S +   +  + SE   E 
Sbjct: 1935 ------LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALD-QLSEKMKEK 1987

Query: 1180 FSELENSEETRTESWELKN-QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1238
              ELE+ +       ++   ++ +  E L  L +D         +LL D + L++KL+ L
Sbjct: 1988 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS-------ELLKDKTHLQEKLQSL 2040

Query: 1239 ERIPEASPKYKLLYED----VSRENDCLQEELRMMETRYDEA----LENNKELTAEVFRL 1290
            E+  +A    K   E+    +++E + L +E   ++ R  E+    L  +K L A +   
Sbjct: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100

Query: 1291 QDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEA 1350
             +   ++    E    L +  +++++  E      L +  K+++ +       D      
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD------ 2154

Query: 1351 SLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIA 1410
             +ENLE E     LQ+++  +E V          E  K E + L+  TQ+ E  ++ ++ 
Sbjct: 2155 KVENLERE-----LQMSEENQELVILDA------ENSKAEVETLK--TQIEEMARSLKVF 2201

Query: 1411 WLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF---------QHQATIAELELEKTKL 1461
             L   +    E+  +  Q+  +E    L   DK           + QA I   E  KT +
Sbjct: 2202 ELD-LVTLRSEKENLTKQI--QEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAV 2258

Query: 1462 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1521
            + L  +LKE        + V +    +E +KA    L     E  Q    +     +L+ 
Sbjct: 2259 EMLQNQLKEL------NEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
            +       +  L E +  ++L  G +   + E+  +     QE+AA++   EN K ++  
Sbjct: 2313 DEKKQLCVLQQLKESEHHADLLKGRVENLEREL--EIARTNQEHAALE--AENSKGEVET 2368

Query: 1582 LKIKNQ---------QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEE 1632
            LK K +         +LD+      ++N  N+  LQ+  +R++E+  +       + L+E
Sbjct: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNE--LQKEQERISEL--EIINSSFENILQE 2424

Query: 1633 REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRC 1692
            +EQEK  +KE+       SST +  L+ +L E+  +   +  +    K + + +     C
Sbjct: 2425 KEQEKVQMKEK-------SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVEC 2477

Query: 1693 PDLSD----------------FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL 1736
             +L                   Q  ++ ++   E   ++ E   EE++   +++     L
Sbjct: 2478 LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQL 2537

Query: 1737 EHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ-------NLEDTVQNVNLQMSRMKSDL 1789
              +++ ++ E + W+ Q+  L++  V  ++K+Q       +L+DT++ +      ++++L
Sbjct: 2538 VSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597

Query: 1790 RVTQQEKEALKQEV--MSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWD---KLDHL 1844
             +T+ +K +  ++V  M+  +          A + A     L  ++ RL+ +    L+ +
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2657

Query: 1845 MNEEQQL--LWQENERLQTMVQNTKAELTHSREKVRQ--LESNLL-----PKHQKHLNPS 1895
             + + QL  L  EN  L+  +     +      KVR+   E  L       KHQ  L  +
Sbjct: 2658 KSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717

Query: 1896 GTMNPTE----QEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQV 1951
                  E    +EKL+ K EC   QK       ++  + S ++EL      N  LK    
Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQK------LEIDLLKSSKEEL------NNSLKATTQ 2765

Query: 1952 KLDE-QLMEMQHLR-STATPSPSPHAWDLQLLQQQACPMVPRE-QFLQLQRQLLQAERIN 2008
             L+E +  +M +L+        +  A     L  ++C  +  E + LQ +   LQA +  
Sbjct: 2766 ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEK 2825

Query: 2009 QHLQEELENRTSETNTPQALLP---EQRAVHADSY 2040
            Q     ++ +  E  T    L    E++   AD Y
Sbjct: 2826 QKTGTVMDTKVDELTTEIKELKETLEEKTKEADEY 2860



 Score =  139 bits (350), Expect = 3e-32
 Identities = 248/1139 (21%), Positives = 484/1139 (42%), Gaps = 196/1139 (17%)

Query: 278  RRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNI 337
            +R  TS  + S +         + +G  +V ++ D+W+E  ++   E+ +    S   +I
Sbjct: 1858 QRVETSEGLNSDLEMHADKSSREDIGD-NVAKVNDSWKERFLDVENELSRIR--SEKASI 1914

Query: 338  NLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLK 397
                L L  + E++ T+    +    + +  I  L E +  V  E+ +LR +LD   K  
Sbjct: 1915 EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT 1974

Query: 398  SLM---ASEVDDHHAAIERRNE---YNLRKLDEEYKERIAALK------NELRKEREQI- 444
            + +   + ++ +    +E       + ++  + E KE+   L+      +EL K++  + 
Sbjct: 1975 TALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQ 2034

Query: 445  --LQQAGKQ-------RLELEQEIEKAKTEENYI-------RDRLALS----LKENSRLE 484
              LQ   K        + ELE +I +   E+  +       + RL+ S    L  +  LE
Sbjct: 2035 EKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE 2094

Query: 485  NELLENAE---KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 541
              L+E  E   +L+  +   ++L+R +E +      D          ++  + +   E E
Sbjct: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK--------KQLHIAEKLKERE 2146

Query: 542  RQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
            R+   L+D+V+ L+ EL+       ++ L  +NS +E     +   E    L   E + +
Sbjct: 2147 RENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENE 661
             +  E E + +Q++E+  +       EL+  +  ++  L+E     ++A+  +K+  +  
Sbjct: 2207 TLRSEKENLTKQIQEKQGQ-----LSELDKLLSSFKSLLEEK----EQAEIQIKEESKTA 2257

Query: 662  THTLEKQISDLKNEIAELQGQAAVLK----------EAHHEATCRHE--------EEKKQ 703
               L+ Q+ +L   +A L G   ++K          E  H+     E        +EKKQ
Sbjct: 2258 VEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ 2317

Query: 704  LQV--KLEEEKTH---LQEKL-RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRG 757
            L V  +L+E + H   L+ ++  L+ E+E+ AR  Q  A+ E E    +     + K+ G
Sbjct: 2318 LCVLQQLKESEHHADLLKGRVENLERELEI-ARTNQEHAALEAENSKGEVET-LKAKIEG 2375

Query: 758  LTQELEQFHQEQLTSLVEK----HTLEKEELR---KELLEKHQRELQEGREKMETECNRR 810
            +TQ L     + +T   EK    + L+KE+ R    E++      + + +E+ + +   +
Sbjct: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEK 2435

Query: 811  TSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ-WEFEKDELTQEC 869
            +S      Q+  +++ ER  +AL +      QE    +EQ    + +  E EK +L Q  
Sbjct: 2436 SSTAMEMLQTQLKELNERV-AALHN-----DQEACKAKEQNLSSQVECLELEKAQLLQGL 2489

Query: 870  AEAQELLKETLKREKTTSLVLTQE--REMLEKTYKE--HLNSMVVERQQLLQDLEDLRNV 925
             EA+      + +     L+   E  ++ LEK  +E   L + + +++QL+  L  +   
Sbjct: 2490 DEAKN--NYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV--- 2544

Query: 926  SETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEM-- 983
             E +  L  +Q LEL++    EL ++ +VL    AS Q     LE L+  +     E+  
Sbjct: 2545 -EGEHQLWKEQNLELRNL-TVELEQKIQVLQSKNASLQ---DTLEVLQSSYKNLENELEL 2599

Query: 984  --MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSG--CQVI 1039
              M K+  +E ++K T +  +            LQ ++ EM Q T+ L    SG   ++ 
Sbjct: 2600 TKMDKMSFVEKVNKMTAKETE------------LQREMHEMAQKTAELQEELSGEKNRLA 2647

Query: 1040 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE 1099
            GE ++  +   S   Q ++L  EN ++  SL   H+  V++  K+  EI+  Q RL + E
Sbjct: 2648 GELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAE 2707

Query: 1100 PGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG 1159
                                 +     L  N+  +VE  T R  L+  E+          
Sbjct: 2708 --------------------KKHQALLLDTNKQYEVEIQTYREKLTSKEE---------- 2737

Query: 1160 TSSVQRQEVKI-----EESEASVEGFSE-LENSEETRTESWELKNQI----SQLQEQLMM 1209
              S Q+ E+ +     EE   S++  ++ LE  ++T+ ++ +  NQ+     + Q ++ +
Sbjct: 2738 CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKL 2797

Query: 1210 LCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1269
            L   C +  E+K+       +L+K+L  L+   E                   Q+   +M
Sbjct: 2798 LIKSCKQLEEEKE-------ILQKELSQLQAAQEK------------------QKTGTVM 2832

Query: 1270 ETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1328
            +T+ DE     KEL      L+++ K+ +E  + + SL  S+++++   E L   V  L
Sbjct: 2833 DTKVDELTTEIKELKE---TLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888



 Score =  134 bits (336), Expect = 1e-30
 Identities = 286/1425 (20%), Positives = 581/1425 (40%), Gaps = 291/1425 (20%)

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRE---------LQEGREKMETECNRRTS 812
            LE++ +   T  ++K    + +L K   EK QR+         LQ+ ++K+E E    T+
Sbjct: 5    LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64

Query: 813  QIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEA 872
                  + + Q++ E CES L+  + +   EL+  + Q   ++ Q    K ++       
Sbjct: 65   -----LKRENQRLMEICES-LEKTKQKISHELQVKESQVNFQEGQLNSGKKQI------- 111

Query: 873  QELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSL 932
             E L++ LKR K+           LE++            QQ  Q  +   N   T Q +
Sbjct: 112  -EKLEQELKRCKSE----------LERS------------QQAAQSADVSLNPCNTPQKI 148

Query: 933  LSDQIL-----------ELKSSHKRELREREEVLCQAGASE-QLASQRLERLEMEH-DQE 979
             +  +            +LK  + +E+ ER+ +  +  A + + ASQ L +  M H D  
Sbjct: 149  FTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIA 208

Query: 980  RQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVI 1039
            R +  S + + +     +  +++ +R  +  + S   S     Q+ T   S LQ G +  
Sbjct: 209  RHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS--ASYFSGEQEVTPSRSTLQIGKRDA 266

Query: 1040 GEEEVEGDGALSLLQ----QGEQLLEENGDVLLSLQRAHEQAVKENVKMATEIS-RLQQ- 1093
                 +   +  LL     Q ++L  +  ++ L LQ  HE+ +K  V    E+  +L++ 
Sbjct: 267  NSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQ-GHEKEMKGQVNKFQELQLQLEKA 325

Query: 1094 RLQKLEPGLVMSSCLDE-PATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEV 1152
            +++ +E   V++ C DE   T    + A      L+Q   K  E ++ +           
Sbjct: 326  KVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ----------- 374

Query: 1153 RDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLM---- 1208
            R    +   S++ Q++K +E E   E   +  + +    E  ++K +++Q  +Q      
Sbjct: 375  RQNAESARCSLE-QKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433

Query: 1209 MLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASP----KYKLLYEDVSRENDCLQ- 1263
            +L A+ D+ +  KQ L  ++   K+KL   E+  +AS     + +   E++ +EN+ L+ 
Sbjct: 434  VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKS 493

Query: 1264 ------------------------------EELRMMETRYDEALENNKE--------LTA 1285
                                          EE++   T  +  L + +E        LT 
Sbjct: 494  HSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTL 553

Query: 1286 E--------------------------VFRLQDELKKMEEVTETFLSL----EKSYDEVK 1315
            E                          + +L D+L K E+ ++  LS     +K Y+E+K
Sbjct: 554  EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK 613

Query: 1316 IE-------NEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQ 1368
             E         E   L+ +++ + E LQ S +   + CL    +++ E       L++++
Sbjct: 614  EEKTLFSCWKSENEKLLTQMESEKENLQ-SKINHLETCLKTQQIKSHEYNERVRTLEMDR 672

Query: 1369 TLEECVPRVRSVHHVIE--------------ECKQENQYLEGNTQLLEKVKAHEIAWLHG 1414
              E     +R++H+V++              E +Q+ ++ +   Q   +    + + L G
Sbjct: 673  --ENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTG 730

Query: 1415 TIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTI 1474
             ++  + + ++ +  I++++     +QD H ++++    L+ +   L  +T +  +R  +
Sbjct: 731  QVEDLEHKLQLLSNEIMDKDRC---YQDLHAEYESLRDLLKSKDASL--VTNEDHQRSLL 785

Query: 1475 LVKQKDVLSHG------------EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQE 1522
               Q+  + H              +  E +          + +Q +V+ L +  E  +Q 
Sbjct: 786  AFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQM 845

Query: 1523 NSILR---NEITTLNEEDSISNLKLGTLNGS-QEEMWQKTETVKQENAAVQKMVEN---- 1574
            NS L+    E+  +  E   + +K   ++ S   E  Q+   ++++ +A Q +V      
Sbjct: 846  NSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSA 905

Query: 1575 LKKQISELKIKNQQLDLENTELSQKNSQN---QEKLQELNQRLTEMLCQKEKEPGN---- 1627
            L+ +  EL++ N +++ E  E+ +    N   ++ L+EL Q L+E L  ++KE  +    
Sbjct: 906  LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKEL-QLLSETLSLEKKEMSSIISL 964

Query: 1628 --SALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEK 1685
                +EE  QE   LKE       +   L+   E+  + +  +   + + +   K   EK
Sbjct: 965  NKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQ--EK 1022

Query: 1686 MKQLHRCPD----LSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA 1741
            +  L RC +      D  QK  +    N KL    E L   LN C      +SL E+R  
Sbjct: 1023 LILLQRCEETGNAYEDLSQKYKAAQEKNSKL----ECL---LNEC------TSLCENRKN 1069

Query: 1742 TMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQM-SRMKSDLRVTQQEKEALK 1800
             ++Q ++++  +     ++L  ++E+ QNL   ++ V   + S M  +   ++ E   LK
Sbjct: 1070 ELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLK 1129

Query: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860
            QE+M+L K+ QN                                M +E   L QENE+L 
Sbjct: 1130 QEIMTL-KEEQNK-------------------------------MQKEVNDLLQENEQLM 1157

Query: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920
             +++        ++ + + LES  +    K          +E+ + + K + D   KE S
Sbjct: 1158 KVMK--------TKHECQNLESEPIRNSVKE-------RESERNQCNFKPQMDLEVKEIS 1202

Query: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLM--EMQHLRSTATPSPSPHAWDL 1978
                 +   N+   +LE + L N+ LK ++ + +++ +  E+Q +R     S        
Sbjct: 1203 -----LDSYNAQLVQLEAM-LRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQ 1256

Query: 1979 QLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2023
            ++   + C +   E+++    +L  ++  N HLQ  L+   ++ N
Sbjct: 1257 EISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLN 1301



 Score =  134 bits (336), Expect = 1e-30
 Identities = 389/1971 (19%), Positives = 766/1971 (38%), Gaps = 322/1971 (16%)

Query: 256  SASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQ 315
            S+++    ++R  S   F  SG +  T S  T  IG R          ++S   +LD   
Sbjct: 229  SSNSQRTPIRRDFSASYF--SGEQEVTPSRSTLQIGKR--DANSSFFDNSSSPHLLDQ-- 282

Query: 316  EEGIENSQEILKALDFSLDGNINLTELTL-ALENELLVTKNSIHQAALASFKAEIRHLLE 374
                      LKA +  L   IN  EL L   E E+    N   +  L   KA++  L+E
Sbjct: 283  ----------LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVE-LIE 331

Query: 375  RV-------DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR-KLDEEY 426
            +        D++VR   +      K   L+  +    +D   + +R+N  + R  L+++ 
Sbjct: 332  KEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTED--LSCQRQNAESARCSLEQKI 389

Query: 427  KERIAALKNELRKER---EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRL 483
            KE+    + EL +++   + + Q+  + +  L QE+++AK   N ++  L        +L
Sbjct: 390  KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449

Query: 484  ENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQ 543
            EN L E  +KL   E      Q                      ++E  L +   E +++
Sbjct: 450  ENNLEEFKQKLCRAEQAFQASQ----------------------IKENELRRSMEEMKKE 487

Query: 544  CRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNM 603
              +L+   ++   E+    A+ + ++  L  S +                 +EE    N 
Sbjct: 488  NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN----------------FAEEMKAKNT 531

Query: 604  SIEAELVIEQMKEQHHRDICCLRLE-LEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 662
            S   E ++  ++E+ ++    L LE L+  V   EKQ D +    KK + +++Q ++  +
Sbjct: 532  S--QETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589

Query: 663  HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ 722
             T EK+   L + +   + +   LKE     +C   E +K L  ++E EK +LQ K+   
Sbjct: 590  KT-EKESKALLSALELKKKEYEELKEEKTLFSCWKSENEK-LLTQMESEKENLQSKIN-H 646

Query: 723  HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 782
             E  LK +  ++    ER R         E     L+ E+   H    +  VE  T +  
Sbjct: 647  LETCLKTQQIKSHEYNERVRT-------LEMDRENLSVEIRNLHNVLDSKSVEVETQKLA 699

Query: 783  ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQ 842
             +  EL +K +   Q+ ++++E  C  +TSQ+  Q         E  E  LQ L      
Sbjct: 700  YM--ELQQKAEFSDQKHQKEIENMC-LKTSQLTGQ--------VEDLEHKLQLLS----N 744

Query: 843  ELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 902
            E+ D     ++  +++E  +D L  +  +A  +  E  +R    SL+   ++  +  ++ 
Sbjct: 745  EIMDKDRCYQDLHAEYESLRDLLKSK--DASLVTNEDHQR----SLLAFDQQPAMHHSFA 798

Query: 903  EHL---NSMVVERQQ-------------LLQDLEDLRNVS-ETQQSLLSD------QILE 939
              +    SM  ER +             +LQ+  D    S E+Q+ + SD      ++++
Sbjct: 799  NIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858

Query: 940  LKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA--- 996
            +K   +  L + E+ + Q+  +E   SQR+ +L+ +    +  +   L A+EN  K    
Sbjct: 859  IKGEIEENLMKAEQ-MHQSFVAE--TSQRISKLQEDTSAHQNVVAETLSALENKEKELQL 915

Query: 997  ---TCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSL- 1052
                 ET   E  E+      L+  +KE+Q  +  LS+          E+ E    +SL 
Sbjct: 916  LNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSL----------EKKEMSSIISLN 965

Query: 1053 LQQGEQLLEENG---DVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1109
             ++ E+L +ENG   ++  SL +     ++++   A  I   ++ + +L         + 
Sbjct: 966  KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025

Query: 1110 EPATEFFGNTAE---QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQ 1166
                E  GN  E   Q     Q+  +K    +     L +   +E+  L        Q  
Sbjct: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085

Query: 1167 EVKIEESE-------ASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASE 1219
              K+  +E         +E   +   SE T  ++   K++   L++++M L  + ++  +
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQQALRSEMTDNQN-NSKSEAGGLKQEIMTLKEEQNKMQK 1144

Query: 1220 KKQDLLFDVSVLKKKLKMLERIP--EASPKYKLLYEDVSRENDC---LQEELRMMETRYD 1274
            +  DLL +   L K +K        E+ P    + E  S  N C    Q +L + E   D
Sbjct: 1145 EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLD 1204

Query: 1275 ---------EALENNKELTAEVFR-----LQDELKKMEEVTETFLSLEKSYDEV------ 1314
                     EA+  NKEL  +        LQ EL+ +    ET    +    E+      
Sbjct: 1205 SYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDC 1264

Query: 1315 KIENEELNV---------------LVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP 1359
            +I+ EE  +               L   LQ  + KL E           E   E L+ E 
Sbjct: 1265 EIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE----------LEKICEILQAEK 1314

Query: 1360 DGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH 1419
               + +LN +  EC+   R +   + +   E + L  ++ LL      +I       Q +
Sbjct: 1315 YELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPN 1374

Query: 1420 QERP---------RVQNQVILEENTTLLGF---QDKHFQHQATIAELELEKTKLQELTRK 1467
            ++ P              + L +    + F   Q+K    Q+    L  +  ++     +
Sbjct: 1375 EQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSE 1434

Query: 1468 LKERVTILVKQKDVLS------HGEKEEEL-----KAMMHDLQITCSEMQQKVELLRYES 1516
            L+  V  L  +  VLS       G+  +E+     + ++  L  +C      +  L    
Sbjct: 1435 LQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSL---- 1490

Query: 1517 EKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQ--------EEMWQKTETVKQENAAV 1568
                 ++S  R  +    +   +SNL+ G ++ +Q          + ++  T K+  +A 
Sbjct: 1491 ----GDSSFYRALLEQTGDMSLLSNLE-GAVSANQCSVDEVFCSSLQEENLTRKETPSAP 1545

Query: 1569 QKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLT----EMLCQKEKE 1624
             K VE L+   S  ++  Q L+    ++  +     +++QEL Q L+    E+ C +++ 
Sbjct: 1546 AKGVEELE---SLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQY 1602

Query: 1625 PGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELE 1684
               +   +++     L+ E +    +  T   SLE E++ +++Q   +   + L  D  +
Sbjct: 1603 LSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTED 1662

Query: 1685 KMKQLHRCPDLS--DFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIAT 1742
             ++  +   D+S     +       ++   + +K+A  ++LN  ++K+ ++  ++     
Sbjct: 1663 AIQGRNESCDISKEHTSETTERTPKHDVHQICDKDA-QQDLNLDIEKITETGAVKPTGEC 1721

Query: 1743 MKQE----------------------QKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL 1780
              ++                      + S+   +A +    + +QE + NL+  V+  + 
Sbjct: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781

Query: 1781 QMSRMKSDLRVTQQEKEALKQEVMSLHKQL-----QNAGGKSWAPEIATHPSGLHNQQKR 1835
            +  R+   +    ++ E+L  E+  L  +L     Q         E+      L  +   
Sbjct: 1782 ENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSD 1841

Query: 1836 LSWDKLDHLMNEEQQLLW--QENERLQTMVQ--------------------NTKAELTHS 1873
            LS +KL++   + Q+LL   + +E L + ++                    + K      
Sbjct: 1842 LS-EKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDV 1900

Query: 1874 REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKE----QSPANRKVSQM 1929
              ++ ++ S       + L     +   + EKL L+++ +  QK     +   +   S+ 
Sbjct: 1901 ENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSER 1960

Query: 1930 NSLEQELETIHLE-------NEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQ 1982
            N L  EL+T+  +       +E +K+K  +L+    E  H    A          LQ L 
Sbjct: 1961 NQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLS 2020

Query: 1983 QQACPMVPREQFLQLQRQLLQAERINQHLQE-ELENRTSETNTPQALLPEQ 2032
                 ++  +  LQ + Q L+ +     L + ELEN+ ++ N  + LL ++
Sbjct: 2021 SDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKE 2071



 Score =  130 bits (328), Expect = 1e-29
 Identities = 319/1648 (19%), Positives = 627/1648 (38%), Gaps = 282/1648 (17%)

Query: 437  LRKEREQILQQAGKQRLELEQEIEKAKTEEN---YIRDRLALSL-KENSRLENELLENAE 492
            L + +E +  +A ++  ELE +++K K E+    +  D L  +L K+  ++ENE  E   
Sbjct: 5    LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT- 63

Query: 493  KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 552
                  NL  + QR +E                     E L + + +   + +V + QV+
Sbjct: 64   ------NLKRENQRLMEIC-------------------ESLEKTKQKISHELQVKESQVN 98

Query: 553  ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612
              + +L   + Q   L   LK   SE   +       +  L     NP N   +      
Sbjct: 99   FQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSL-----NPCNTPQKI----- 148

Query: 613  QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDL 672
                                   +   L  +        E++K+++  E    ++  +++
Sbjct: 149  -----------------------FTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185

Query: 673  KNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLT 732
            K   A+   Q       +H    RH+        + E+  +HL       +      R  
Sbjct: 186  KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLS-----SNSQRTPIRRD 240

Query: 733  QAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKH 792
             + + F  E+E   S +  +   R        F       L+++   + +ELR ++ E  
Sbjct: 241  FSASYFSGEQEVTPSRSTLQIGKRDANSSF--FDNSSSPHLLDQLKAQNQELRNKINELE 298

Query: 793  QRELQEGREKMETECNRRTSQIEAQFQS------DCQKVTERCESALQSLEGRY------ 840
             R LQ   ++M+ + N +  +++ Q +       + +KV  +C   L     +Y      
Sbjct: 299  LR-LQGHEKEMKGQVN-KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTK 356

Query: 841  ----RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREM 896
                 Q+LK L E    ++   E  +  L Q+  E ++  +E L R++ +   L QE   
Sbjct: 357  YTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE--- 413

Query: 897  LEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLC 956
                        +  + +L Q+L+  +N+    Q+ L D++  +K   +  L E ++ LC
Sbjct: 414  -----------CIQMKARLTQELQQAKNMHNVLQAEL-DKLTSVKQQLENNLEEFKQKLC 461

Query: 957  QAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQ 1016
            +A  + Q ASQ  E        E +  M ++    N+ K+  E   RE   +  E+  ++
Sbjct: 462  RAEQAFQ-ASQIKE-------NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIK 513

Query: 1017 SKIKEMQ--------QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
              + + Q        + TS  +ML+   + I ++  E    L  L+     LE+  D   
Sbjct: 514  QCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ--ENSLTLEKLKLAVADLEKQRDCSQ 571

Query: 1069 SLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFL 1127
             L +  E  +++ N K++      +  L  LE        L E  T F    +E  +   
Sbjct: 572  DLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLT 631

Query: 1128 QQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1187
            Q    K+       H+ + L+  +++         V+  E+  E     +     + +S+
Sbjct: 632  QMESEKENLQSKINHLETCLKTQQIK--SHEYNERVRTLEMDRENLSVEIRNLHNVLDSK 689

Query: 1188 ETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK 1247
                E+ +L           M L    + + +K Q  + ++ +  K  ++  ++ +   K
Sbjct: 690  SVEVETQKL---------AYMELQQKAEFSDQKHQKEIENMCL--KTSQLTGQVEDLEHK 738

Query: 1248 YKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSL 1307
             +LL  ++  ++ C Q                  +L AE   L+D LK            
Sbjct: 739  LQLLSNEIMDKDRCYQ------------------DLHAEYESLRDLLK------------ 768

Query: 1308 EKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIE--PDGNILQ 1365
             K    V  E+ + ++L    Q  +     +++        E S   LE +  P  + + 
Sbjct: 769  SKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAIL 828

Query: 1366 LNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRV 1425
             N        RV S+   +E  KQ N  L+   + L ++K      L    Q HQ     
Sbjct: 829  QN--------RVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQ----- 875

Query: 1426 QNQVILEENTTLLGFQDKHFQHQATIAE----LELEKTKLQELTRKLKERVTILVKQKDV 1481
                + E +  +   Q+    HQ  +AE    LE ++ +LQ L  K++       +Q ++
Sbjct: 876  --SFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVE------TEQAEI 927

Query: 1482 LSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISN 1541
                   +ELK   H L+ +  E+Q   E L  E +++    S+ + EI  L +E+    
Sbjct: 928  -------QELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLK 980

Query: 1542 LKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKI----KNQQLDLENTELS 1597
                +LN  +  + QK+E+        +K +  L  Q  + K+    + ++      +LS
Sbjct: 981  EINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLS 1040

Query: 1598 QKNSQNQEKLQELNQRLTE--MLCQKEKEPGNSALE--EREQEKFNLK-----EELERCK 1648
            QK    QEK  +L   L E   LC+  K       E   +E ++F  K     E  +   
Sbjct: 1041 QKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLM 1100

Query: 1649 VQSSTLVSSLEAELSE----VKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISS 1704
            ++  T+  +L +E+++     K +   ++QE   LK+E  KM            Q++++ 
Sbjct: 1101 LELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKM------------QKEVND 1148

Query: 1705 VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVAS 1764
            +L  NE+L+K  +   E  N           LE        +++  E    + K Q+   
Sbjct: 1149 LLQENEQLMKVMKTKHECQN-----------LESEPIRNSVKERESERNQCNFKPQMDLE 1197

Query: 1765 QEKVQNLEDTVQNVNLQMSRMKSDLRV--TQQEKEALKQEVMSLHKQLQNAGGKSW-APE 1821
             +++       Q V L+      +L++  +++EKE L+ E+ ++   L+ +  +   + E
Sbjct: 1198 VKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQE 1257

Query: 1822 IA-----------THPSGLH--------NQQKRLSWDKLDHLMNEEQ---QLLWQENERL 1859
            I+            + SG H        N   + S     + +NE +   ++L  E   L
Sbjct: 1258 ISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYEL 1317

Query: 1860 QTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQ 1919
             T + ++++E   +  K+ +    LL + +   + SG ++    E +      +Q  ++ 
Sbjct: 1318 VTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQH 1377

Query: 1920 SPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQ 1979
              +   + + NS E     + L ++ ++    +L E+ + +Q          S H    +
Sbjct: 1378 PVSLAPLDESNSYEH----LTLSDKEVQMHFAELQEKFLSLQ----------SEH----K 1419

Query: 1980 LLQQQACPMVPREQFLQLQRQLLQAERI 2007
            +L  Q C M  +   LQ     L+AE +
Sbjct: 1420 ILHDQHCQMSSKMSELQTYVDSLKAENL 1447



 Score =  127 bits (320), Expect = 9e-29
 Identities = 261/1243 (20%), Positives = 508/1243 (40%), Gaps = 193/1243 (15%)

Query: 333  LDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDK 392
            LD  ++L E+ L  + E  +    I    +   K E   L E+++    + ++L   ++ 
Sbjct: 1807 LDSKLHLQEVQLMTKIEACIELEKI----VGELKKENSDLSEKLEYFSCDHQELLQRVET 1862

Query: 393  AEKLKSLMASEVDDHHAAIERRNEY--NLRKLDEEYKERIAALKNEL---RKEREQILQQ 447
            +E L S +     + HA    R +   N+ K+++ +KER   ++NEL   R E+  I  +
Sbjct: 1863 SEGLNSDL-----EMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 1917

Query: 448  AGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRN 507
            A    L LE ++E  +TE      +L L  K+N   +  ++   E+L+   +  N+L+  
Sbjct: 1918 A----LYLEADLEVVQTE------KLCLE-KDNENKQKVIVCLEEELSVVTSERNQLRGE 1966

Query: 508  LENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRV 567
            L+  +++K   LD  S +   + + L   ++E     +V + +V E    L+   +    
Sbjct: 1967 LDT-MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD--- 2022

Query: 568  LRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRL 627
                                                      V E +K++ H        
Sbjct: 2023 ------------------------------------------VSELLKDKTH-------- 2032

Query: 628  ELEDKVRHYEKQLDETVVSCKKAQ-ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVL 686
             L++K++  EK  D   +S  K + EN   +   E   L K+   L+  ++E   +   +
Sbjct: 2033 -LQEKLQSLEK--DSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNV 2089

Query: 687  KEAHHEATCRHEEEKKQLQVKLEEEKTHLQ----EKLRLQHEMELKARLTQAQASFERER 742
             +A   A    E+ +  L++   +E+ H      EKLR++ E + K +L  A+   ERER
Sbjct: 2090 SKALEAALV--EKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERER 2147

Query: 743  EGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE-ELRKELLEKHQRELQEGRE 801
            E        ++KV  L +EL+   + Q   +++    + E E  K  +E+  R L+    
Sbjct: 2148 ENDS----LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFEL 2203

Query: 802  KMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFE 861
             + T  + + + +  Q Q    +++E     L  L   ++  L        EEK Q E +
Sbjct: 2204 DLVTLRSEKEN-LTKQIQEKQGQLSE-----LDKLLSSFKSLL--------EEKEQAEIQ 2249

Query: 862  KDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLED 921
               + +E   A E+L+  LK        L  ++E+++ T ++ L+  + E  QL   +E 
Sbjct: 2250 ---IKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKAT-EQSLDPPIEEEHQLRNSIEK 2305

Query: 922  LRNVSETQQSLLSDQILELKSS--HKRELREREEVLCQAGASEQLASQRLERLEMEHDQE 979
            LR   E  +      + +LK S  H   L+ R E L +     ++A    E   +E +  
Sbjct: 2306 LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLER---ELEIARTNQEHAALEAENS 2362

Query: 980  RQEMMSKLLAMENIHKAT------CETADRERAEMSTEISRLQSKIKEMQQATSPL-SML 1032
            + E+ +    +E + ++         T   E+  ++ E+ + Q +I E++   S   ++L
Sbjct: 2363 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL 2422

Query: 1033 QSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQ 1092
            Q   Q   + + +   A+ +LQ     L+E  + + +L    E    +   +++++  L+
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQ---LKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479

Query: 1093 QRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEV 1152
                +L  GL      DE    +           LQ +    ++ V       + +D+E+
Sbjct: 2480 LEKAQLLQGL------DEAKNNYI---------VLQSSVNGLIQEVEDGKQKLEKKDEEI 2524

Query: 1153 RDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEET-RTESWELKNQISQLQEQLMMLC 1211
                        R + +I++ E  V   S++E   +  + ++ EL+N   +L++++ +L 
Sbjct: 2525 -----------SRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVL- 2572

Query: 1212 ADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEEL-RMME 1270
                    K   L   + VL+   K LE   E +   K+ + +   +    + EL R M 
Sbjct: 2573 ------QSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMH 2626

Query: 1271 TRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQG 1330
                +  E  +EL+ E  RL  EL+ +    E   S +    E+ +EN EL    L    
Sbjct: 2627 EMAQKTAELQEELSGEKNRLAGELQLL---LEEIKSSKDQLKELTLENSELKKS-LDCMH 2682

Query: 1331 KIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQ--------------TLEECVPR 1376
            K +  +E  V+  +   ++  L   E +    +L  N+              + EEC+  
Sbjct: 2683 KDQVEKEGKVRE-EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSS 2741

Query: 1377 VRSVHHVIEECKQE-NQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENT 1435
             +    +++  K+E N  L+  TQ+LE++K  ++  L    Q  +E  R Q ++      
Sbjct: 2742 QKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM------ 2795

Query: 1436 TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMM 1495
             LL    K  + +  I + EL  ++LQ    K K    +  K  ++ +   + +ELK  +
Sbjct: 2796 KLLIKSCKQLEEEKEILQKEL--SQLQAAQEKQKTGTVMDTKVDELTT---EIKELKETL 2850

Query: 1496 HDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDS 1538
             +      E   K   L    EKL++   +L  ++  L  + S
Sbjct: 2851 EEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQS 2893



 Score =  126 bits (316), Expect = 2e-28
 Identities = 344/1638 (21%), Positives = 661/1638 (40%), Gaps = 230/1638 (14%)

Query: 311  LDTWQEEGIENSQEILKALDFSLDG--------NINLTELTLALENELLVTKNSIHQAAL 362
            L+ W+E     + + ++ L+  LD            L  L  AL+ +    +N   +   
Sbjct: 5    LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT- 63

Query: 363  ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKL 422
             + K E + L+E  + + + K+K+  +L   E   +    +++     IE+  +   R  
Sbjct: 64   -NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122

Query: 423  DEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 482
             E  + + AA   ++        Q+     L   Q    +K E+  ++++    ++E  R
Sbjct: 123  SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYED--LKEKYNKEVEERKR 180

Query: 483  LENELLE-NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 541
            LE E+    A+K ++         R++    A        SS+ F  Q+E+     +   
Sbjct: 181  LEAEVKALQAKKASQTLPQATMNHRDIARHQA--------SSSVFSWQQEKTPSHLSSNS 232

Query: 542  RQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
            ++  + +D      S  +E       L++  +++ S   + NS        L ++     
Sbjct: 233  QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFD-NSSSPHLLDQLKAQNQELR 291

Query: 602  NMSIEAELVIE----QMKEQHHRDICCLRLELED-KVRHYEKQLDETVVSCKKAQENMKQ 656
            N   E EL ++    +MK Q ++    L+L+LE  KV   EK  ++ +  C+        
Sbjct: 292  NKINELELRLQGHEKEMKGQVNK-FQELQLQLEKAKVELIEK--EKVLNKCRDELVRTTA 348

Query: 657  RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
            +++  +     + + L+ ++ +L    +  ++    A C  E++ K+ + + +EE +  Q
Sbjct: 349  QYDQAS----TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404

Query: 717  EKLRL--QHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 774
               +   Q  +++KARLTQ     +     LQ+     +K+  + Q+LE   +E      
Sbjct: 405  RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL---DKLTSVKQQLENNLEE------ 455

Query: 775  EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERC--ESA 832
             K  L + E   +  +  + EL+   E+M+ E N   S  E       QK  E C  E+ 
Sbjct: 456  FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE-------QKAREVCHLEAE 508

Query: 833  LQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQ 892
            L++++    Q     +E + +  SQ    +D   QE    QE    +L  EK    V   
Sbjct: 509  LKNIKQCLNQSQNFAEEMKAKNTSQETMLRD--LQEKINQQE---NSLTLEKLKLAVADL 563

Query: 893  EREMLEKTYKEHLNSMVVERQQLLQDLED-LRNVSETQQSLLSDQILELKSSHKRELRER 951
            E++      ++    ++ +R+  ++ L D L    +  ++LLS   LELK     EL+E 
Sbjct: 564  EKQ------RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS--ALELKKKEYEELKE- 614

Query: 952  EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA----------TCETA 1001
            E+ L     SE       E+L  + + E++ + SK+  +E   K              T 
Sbjct: 615  EKTLFSCWKSEN------EKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTL 668

Query: 1002 DRERAEMSTEISRLQSKI--KEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
            + +R  +S EI  L + +  K ++  T  L+ ++                   LQQ  + 
Sbjct: 669  EMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME-------------------LQQKAEF 709

Query: 1060 LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNT 1119
             ++           H+   KE   M  + S+L  +++ LE  L + S         + + 
Sbjct: 710  SDQK----------HQ---KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756

Query: 1120 AEQTEPFLQQNRTKQVEGVTRR-HVLSDLEDDE--------VRDLGSTGTSSVQRQEVKI 1170
              + E      ++K    VT   H  S L  D+           +G  G+   +R E ++
Sbjct: 757  HAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRL 816

Query: 1171 EESEASVEGFSELENSEETRTESWELKNQI-SQLQEQLMMLCADCDRASEKKQDLLFDVS 1229
             E++ S +  + L+N  ++   S E + Q+ S LQ+Q       C+   + K ++  + +
Sbjct: 817  -EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ-------CEELVQIKGEI--EEN 866

Query: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289
            ++K +      + E S +   L ED S   + + E L  +E +  E    N ++  E   
Sbjct: 867  LMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE 926

Query: 1290 LQDELKKMEEVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIEKL--QESVVQRCDCC 1346
            +Q ELKK   + E  L  L+   + + +E +E++ ++   + +IE+L  +   ++  +  
Sbjct: 927  IQ-ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINAS 985

Query: 1347 LWEASLENLEIEPDGNILQLNQTLEECV-PRVRSVHHVIEECKQENQYLEGNTQLLEKVK 1405
            L +  +         N++Q +++    +  R +S+  + ++ KQE   L    +  E   
Sbjct: 986  LNQEKM---------NLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCE--ETGN 1034

Query: 1406 AHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELT 1465
            A+E   L    +  QE+   + + +L E T+L                 E  K +L++L 
Sbjct: 1035 AYED--LSQKYKAAQEK-NSKLECLLNECTSL----------------CENRKNELEQLK 1075

Query: 1466 RKL-KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESE-KLQQEN 1523
                KE    L K    L+  E+  +      +L +    +QQ +     +++   + E 
Sbjct: 1076 EAFAKEHQEFLTK----LAFAEERNQ------NLMLELETVQQALRSEMTDNQNNSKSEA 1125

Query: 1524 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQ----KTETVKQENAAVQKMVENLKKQI 1579
              L+ EI TL EE +    ++  L    E++ +    K E    E+  ++  V+  + + 
Sbjct: 1126 GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER 1185

Query: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN 1639
            ++   K  Q+DLE  E+S  +S N + +Q     L  ML  KE +     L+E E+EK  
Sbjct: 1186 NQCNFK-PQMDLEVKEIS-LDSYNAQLVQ-----LEAMLRNKELK-----LQESEKEKEC 1233

Query: 1640 LKEELE--RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLL-KDELEKMK--QLHRCPD 1694
            L+ EL+  R  +++S L      E+S +K    I  +E ++    EL   +    H    
Sbjct: 1234 LQHELQTIRGDLETSNLQDMQSQEISGLK-DCEIDAEEKYISGPHELSTSQNDNAHLQCS 1292

Query: 1695 LSDFQQKISSVLSYNEKLLKEKEALSEELN-SCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1753
            L     K++ +    E L  EK  L  ELN S  + +  +  +   +  +  E K     
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDD 1352

Query: 1754 SASLKSQLV-----ASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
            S  L  +LV         +  N +  V    L  S     L ++ +E +    E+     
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFL 1412

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1868
             LQ            +    LH+Q  ++S  K+  L      L   EN  L T ++N + 
Sbjct: 1413 SLQ------------SEHKILHDQHCQMS-SKMSELQTYVDSLK-AENLVLSTNLRNFQG 1458

Query: 1869 ELTHSREKVRQLESNLLP 1886
            +L   +E    LE  L+P
Sbjct: 1459 DLV--KEMQLGLEEGLVP 1474


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  160 bits (404), Expect = 2e-38
 Identities = 338/1582 (21%), Positives = 638/1582 (40%), Gaps = 254/1582 (16%)

Query: 341  ELTLALENELLVTKNS--------IHQAALASFKAEIRHLLERVDQVVREKE-----KLR 387
            EL LA   +LL  K++        I + AL + K     L  +  + +R+K      +L 
Sbjct: 234  ELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293

Query: 388  SDLDKAEKLKSLMASEVDDHHAAIERRN---EYNLRKLDEEYKERIAALKNELRKEREQI 444
              L + + LK+   S++D     +   N    + LR+     ++   AL NEL +E  + 
Sbjct: 294  ETLKQCQDLKT-EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDAL-NELTEEHSKA 351

Query: 445  LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL 504
             Q+  +++ +LE+E+  A  ++  + ++            NE+L+   KL++ E   ++L
Sbjct: 352  TQEWLEKQAQLEKELSAALQDKKCLEEK------------NEILQG--KLSQLEEHLSQL 397

Query: 505  QRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSE------- 557
            Q N      E  GD+        L++E  T   N  + Q RV   + +  Q E       
Sbjct: 398  QDNPPQEKGEVLGDVLQLET---LKQEAATLAANNTQLQARVEMLETERGQQEAKLLAER 454

Query: 558  --LEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELV-IEQM 614
               EE + Q   L   L++S S   +A     +     G+     +  S+ +EL  +   
Sbjct: 455  GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQV-ASLTSELTTLNAT 513

Query: 615  KEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKN 674
             +Q  +++  L+ + ++K    + QL +T+   ++A + ++ + E  + +L+++   LK 
Sbjct: 514  IQQQDQELAGLKQQAKEK----QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK- 568

Query: 675  EIAELQGQAAVLKEAHHEATCRHEEEK---------KQLQVKLEEEKTHLQEKLRLQHEM 725
            E+AE Q +A     A   AT   E E          KQL+  LE+EK    E L+ Q ++
Sbjct: 569  EVAEKQ-EATRQDHAQQLATAAEEREASLRERDAALKQLEA-LEKEKAAKLEILQQQLQV 626

Query: 726  ELKAR------LTQAQ---ASFEREREGLQSSAWT----EEKVRGLTQELE-QFHQEQLT 771
              +AR      +TQAQ   A   R+ E LQ+   T    + + +    ELE Q   EQ  
Sbjct: 627  ANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK 686

Query: 772  SLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCES 831
            +  ++   ++++  +E L+  +  L+  +  +E E  R    +E Q     Q+     ++
Sbjct: 687  ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQ-----QRCISELKA 741

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
              +SL  ++++E K+L+E++   K       +   Q+  EA +   E L+RE   ++   
Sbjct: 742  ETRSLVEQHKRERKELEEERAGRKGL-----EARLQQLGEAHQAETEVLRRELAEAMAA- 795

Query: 892  QEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSS---HKREL 948
                  + T +     +V E     +  ED +       ++  +Q++ LK      ++EL
Sbjct: 796  ------QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL 849

Query: 949  REREEVLC--QAGASEQLASQRLERLEMEHDQER--QEMMSKLLAMENIHKATCETADRE 1004
            +E +E +   ++ +  Q++ Q+ E  E+  +  R  Q++  K +  + +      T   +
Sbjct: 850  QEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD-DLSTLQEK 908

Query: 1005 RAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENG 1064
             A  S E++RL++ +++  +     S      +++ E    GD      +Q E L E+ G
Sbjct: 909  MAATSKEVARLETLVRKAGEQQETASR-----ELVKEPARAGD------RQPEWLEEQQG 957

Query: 1065 DVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTE 1124
                S Q A +   +E  +M  E+ RL+  L + +              E  G    +  
Sbjct: 958  RQFCSTQAALQAMEREAEQMGNELERLRAALMESQG----------QQQEERGQQEREVA 1007

Query: 1125 PFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEV---KIEESEASVEGFS 1181
               Q+    Q +    +   ++LE      L          QE     + E E   +  +
Sbjct: 1008 RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELA 1067

Query: 1182 ELENSEETRT-ESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER 1240
            +L   E  +  E  EL+  + QL+EQL         A ++K+      S    + +   R
Sbjct: 1068 KLRGLEAAQIKELEELRQTVKQLKEQL---------AKKEKEH----ASGSGAQSEAAGR 1114

Query: 1241 IPEASPKYKLLYEDVSR-ENDCL--QEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1297
                 PK + L  +VS+ E  C   QE+   +E   +    +  E  + +  LQ +L++ 
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEK 1174

Query: 1298 EEVTETFLSLEKSYDEVKIENEELNVLVLRLQ--GKIEKLQESVVQRCDCCLWEASLENL 1355
             +       L  S   +     EL     ++Q   K E   ++ V R      EA  +N 
Sbjct: 1175 AQ------ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGR---QEAERKNS 1225

Query: 1356 EIEP-DGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAW--- 1411
             I   +  +  LN+ + E     + +  ++    +++Q LE   +LL+   A   A    
Sbjct: 1226 LISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285

Query: 1412 ----LHGTIQT---HQERPRVQNQVILEENTT-----------LLGFQDKHFQHQATIAE 1453
                L   +Q+     E+ RV ++ + +E T+           L  +Q+K FQ +  ++ 
Sbjct: 1286 RSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALST 1345

Query: 1454 LELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLR 1513
            L+LE T  Q L       V+ L+  K +    + E+      H                R
Sbjct: 1346 LQLEHTSTQAL-------VSELLPAKHLCQQLQAEQAAAEKRH----------------R 1382

Query: 1514 YESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ---ENAAVQK 1570
             E E+ +Q    LR E+     E       LG L   ++++ ++  T +Q   E A+  +
Sbjct: 1383 EELEQSKQAAGGLRAELLRAQRE-------LGELIPLRQKVAEQERTAQQLRAEKASYAE 1435

Query: 1571 MVENLKKQISELKIKNQQL--------DLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1622
             +  LKK    L  +N+ L             EL Q   +  ++L  +       L + +
Sbjct: 1436 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ 1495

Query: 1623 KEPGNSALE------EREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQEN 1676
            +E  ++A E      + E  K  + EE +R + +   L + +E        Q  + Q+E 
Sbjct: 1496 REAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE--------QLEVFQREQ 1547

Query: 1677 HLLKDELEKMKQLHRCPDLSDFQQ-KISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSL 1735
                +EL K  +L      S  QQ K+ +V +   +  +E + L  +LN           
Sbjct: 1548 TKQVEELSK--KLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ-------- 1597

Query: 1736 LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE 1795
                 A + Q++++ EH    +        EK +   D  +  N ++      L   Q+E
Sbjct: 1598 -----AQLSQKEQAAEHYKLQM--------EKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644

Query: 1796 KEALKQEVMSLHKQLQNAGGKS 1817
             + L+ E   L  +LQ AG K+
Sbjct: 1645 NKELRAEAERLGHELQQAGLKT 1666



 Score =  149 bits (377), Expect = 2e-35
 Identities = 291/1470 (19%), Positives = 591/1470 (40%), Gaps = 174/1470 (11%)

Query: 362  LASFKAEIRHLLERVDQVVREKEKLRSD-LDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420
            L  F + ++ L + ++++  E  K   + L+K  +L+  +++ + D    +E +NE    
Sbjct: 327  LREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC-LEEKNEILQG 385

Query: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480
            KL +  +E ++ L++   +E+ ++L     Q   L+QE          ++ R+ +   E 
Sbjct: 386  KLSQ-LEEHLSQLQDNPPQEKGEVLGDV-LQLETLKQEAATLAANNTQLQARVEMLETER 443

Query: 481  SRLENELLENA----EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQM 536
             + E +LL       E+  +  +L   LQ ++ N L++   +L+ +S        RLT  
Sbjct: 444  GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN-LSQAKEELEQASQA---HGARLTAQ 499

Query: 537  RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE 596
                  +   L   + +   EL   + Q +  +  L  +  ++ +A+ G       L S 
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559

Query: 597  ECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYE---KQLD----ETVVSCKK 649
                     E     E  ++ H + +     E E  +R  +   KQL+    E     + 
Sbjct: 560  LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619

Query: 650  AQENMKQRHE------NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQ 703
             Q+ ++  +E            +++ ++L  ++ ELQ      ++  HEA  +  E + Q
Sbjct: 620  LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679

Query: 704  L---QVKLEEEKTHLQEKLRLQHEME-LKARLTQAQASFEREREGLQSSAWTEEKVRGLT 759
            L   Q K  E++   QEK +LQ +++ LK  L   + S E E+   +++   EE+ R ++
Sbjct: 680  LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR--RAADALEEQQRCIS 737

Query: 760  QELEQFHQEQLTSLVEKHTLEKEELRKEL-----LEKHQRELQEGREKMETECNRRTSQI 814
            +      + +  SLVE+H  E++EL +E      LE   ++L E  +  ETE  RR    
Sbjct: 738  EL-----KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA-ETEVLRREL-- 789

Query: 815  EAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 874
             A+  +        CE  ++ +   +R+  +D Q+++ +  + ++ +   L +EC +A++
Sbjct: 790  -AEAMAAQHTAESECEQLVKEVAA-WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQ 847

Query: 875  LLKETLKR----EKTTSLVLTQEREMLEKTYK------EHLNSMVVERQQLLQDLEDLRN 924
             L+E  ++    E  + L +++++  L + +       + +    V  Q+L  DL  L+ 
Sbjct: 848  ELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE 907

Query: 925  -VSETQQSLLSDQILELKSSHKRELREREEVLCQAGA-----------------SEQLAS 966
             ++ T + +   + L  K+  ++E   RE V   A A                 S Q A 
Sbjct: 908  KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAAL 967

Query: 967  QRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQAT 1026
            Q +ER   +   E + + + L+  +   +      +RE A ++ E  R Q+ +   + A 
Sbjct: 968  QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027

Query: 1027 SPLSM-LQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMA 1085
            + L M LQ+    + E+ VE       L       E     L  L+      +KE  ++ 
Sbjct: 1028 AELEMRLQNA---LNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084

Query: 1086 TEISRLQQRLQKLEPGLVMSSCLDEPA---TEFFG---------------------NTAE 1121
              + +L+++L K E      S     A   TE  G                       A+
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144

Query: 1122 QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1181
              E  L+  R  + E  +    L    +++ ++LG + ++    Q  ++      V+  S
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQR-ELAAFRTKVQDHS 1203

Query: 1182 ELENSEET-----RTESWELKNQISQLQEQLMMLCADC-DRASEKKQDLLFDVSVLKKKL 1235
            + E+  +      R E+    + IS L+E++ +L     ++  E K+     ++  +K  
Sbjct: 1204 KAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263

Query: 1236 KMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE---ALEN-NKELTAEVFRLQ 1291
            K+ ER+     +        +  +  L+EE++ +    ++   A EN  +ELT++  R +
Sbjct: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323

Query: 1292 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1351
            +  ++++   E F   E++   +++E+     LV  L       Q+  +Q       +  
Sbjct: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ--LQAEQAAAEKRH 1381

Query: 1352 LENLEIEPDG------NILQLNQTLEECVP---RVRSVHHVIEECKQENQYLEGNTQLLE 1402
             E LE            +L+  + L E +P   +V       ++ + E         +L+
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441

Query: 1403 KVKAHEIAWLHGTIQTHQ----ERPRVQNQVILEENTTLLGFQDKHFQHQATI------- 1451
            K         HG +        ER  +  Q +  E   L   ++K+ Q  A +       
Sbjct: 1442 KA--------HGLLAEENRGLGERANLGRQFLEVE---LDQAREKYVQELAAVRADAETR 1490

Query: 1452 -AELELEKT----KLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQ 1506
             AE++ E      +L+ +T K +     +++++      E+ ++L A +  L++   E  
Sbjct: 1491 LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ--EERQKLTAQVEQLEVFQREQT 1548

Query: 1507 QKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENA 1566
            ++VE L  +     Q + + + ++  +  +   S  +   L     E+  +    +Q   
Sbjct: 1549 KQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAE 1608

Query: 1567 AVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG 1626
              +  +E  K      K +NQ+L  +   L Q   +N+E L+   +RL            
Sbjct: 1609 HYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE-LRAEAERLG----------- 1656

Query: 1627 NSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV---QQENHLLKD-E 1682
                 E +Q     KE  + C+   +  V SLEA+++    Q   +   Q     LK  E
Sbjct: 1657 ----HELQQAGLKTKEAEQTCR-HLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1711

Query: 1683 LEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1712
             +   QL    D  D   +  + LS   KL
Sbjct: 1712 PQAKPQLDLSIDSLDLSCEEGTPLSITSKL 1741



 Score =  147 bits (371), Expect = 1e-34
 Identities = 291/1394 (20%), Positives = 545/1394 (39%), Gaps = 223/1394 (15%)

Query: 764  QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE--KMETECNRRTSQIEAQFQSD 821
            QF   +L   +      ++EL  EL E  +   ++  +   M+   +R     E Q  S 
Sbjct: 213  QFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASP 272

Query: 822  CQ-KVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET- 879
             + K  E      +SL  R  + LK  Q+  + EKSQ + + ++L++E  +    L+E  
Sbjct: 273  LEPKELEELRDKNESLTMRLHETLKQCQDL-KTEKSQMDRKINQLSEENGDLSFKLREFA 331

Query: 880  --LKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQD---LEDLRNVSETQQSLLS 934
              L++ +     LT+E     + + E    +  E    LQD   LE+   + + + S L 
Sbjct: 332  SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391

Query: 935  DQILELKSSHKRELRE-----------REEVLCQAGASEQLASQRLERLEMEHDQERQEM 983
            + + +L+ +  +E  E           ++E    A  + QL + R+E LE E  Q+    
Sbjct: 392  EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQA-RVEMLETERGQQE--- 447

Query: 984  MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQA---------------TSP 1028
             +KLLA E  H       + E+ ++S+ I+ LQS I  + QA               T+ 
Sbjct: 448  -AKLLA-ERGH------FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499

Query: 1029 LSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHE--QAVKENVKMAT 1086
            ++ L S    +     + D  L+ L+Q  Q  E+   +  +LQ+  +  Q ++  V+  +
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQ--QAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557

Query: 1087 EISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGVTRRHV- 1143
              S L+Q+ Q+L+          +   +     AE+ E  L++     KQ+E + +    
Sbjct: 558  --SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615

Query: 1144 -LSDLED-----DEVRDLGSTGTSSVQRQEV----KIEESEASVEGFSELENSEETRTES 1193
             L  L+      +E RD   T  +  QR++     K+EE +A VE           R E 
Sbjct: 616  KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE---------TARQEQ 666

Query: 1194 WELKNQISQLQEQL---MMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1250
             E + Q+++L+ QL        + +R +++K  L   +  LK+ LK+ +   E       
Sbjct: 667  HEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLE------- 719

Query: 1251 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1310
              E+  R  D L+E+ R +        E   E  + V + + E K++EE       LE  
Sbjct: 720  --EEKRRAADALEEQQRCIS-------ELKAETRSLVEQHKRERKELEEERAGRKGLEAR 770

Query: 1311 YDEVKIENEELNVLVLRLQGKIEKLQESVVQRCD-----CCLWEASLENLEIEPDGNILQ 1365
              ++   ++    ++ R   +    Q +    C+        W    E+ + E       
Sbjct: 771  LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830

Query: 1366 LNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTI----QTHQE 1421
              + L             ++E K++   +E +++L    + +E+A LH  +    Q  QE
Sbjct: 831  FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890

Query: 1422 RPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ--K 1479
            +  V+ Q + ++ +TL          Q  +A    E  +L+ L RK  E+     ++  K
Sbjct: 891  K-EVRAQKLADDLSTL----------QEKMAATSKEVARLETLVRKAGEQQETASRELVK 939

Query: 1480 DVLSHGEK-----EEELKAMMHDLQITCSEMQQKVELLRYESEKL-----------QQEN 1523
            +    G++     EE+        Q     M+++ E +  E E+L           Q+E 
Sbjct: 940  EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEER 999

Query: 1524 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET-VKQENAAVQKMVENLKKQISEL 1582
                 E+  L +E   +   L     ++ E+  + +  + ++      + E L   ++E 
Sbjct: 1000 GQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEK 1059

Query: 1583 KIKNQQL-DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKE--PGNSALEEREQEKFN 1639
            + K+Q+L  L   E +Q   +  E+L++  ++L E L +KEKE   G+ A  E       
Sbjct: 1060 EGKDQELAKLRGLEAAQ--IKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117

Query: 1640 LKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQ 1699
               +LE           +L AE+S+++ Q    Q++   L                    
Sbjct: 1118 TGPKLE-----------ALRAEVSKLEQQCQKQQEQADSL-------------------- 1146

Query: 1700 QKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKS 1759
                      E+ L+ + A   E +S ++ L      + ++    QE    +   AS + 
Sbjct: 1147 ----------ERSLEAERASRAERDSALETL------QGQLEEKAQELGHSQSALASAQR 1190

Query: 1760 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWA 1819
            +L A + KVQ+          Q++R + +         +L++EV  L++Q+    G+S  
Sbjct: 1191 ELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKE 1250

Query: 1820 PE--IATHPSGLHNQQKRLSWDKLDHLMN------------EEQQLLWQENERLQTMVQN 1865
             +  +          ++RL   + +   N            EE Q L +E E+ +   +N
Sbjct: 1251 LKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASEN 1310

Query: 1866 TKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTE----------QEKLSLKRECDQF 1915
             + ELT   E+  +L   L    +K       ++  +           E L  K  C Q 
Sbjct: 1311 LRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQL 1370

Query: 1916 QKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHA 1975
            Q EQ+ A ++        +ELE       GL+ + ++   +L E+  LR           
Sbjct: 1371 QAEQAAAEKR------HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQER--- 1421

Query: 1976 WDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQA---LLPEQ 2032
               Q L+ +      +   L+    LL  E      +  L  +  E    QA    + E 
Sbjct: 1422 -TAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL 1480

Query: 2033 RAVHADSYRRIGHL 2046
             AV AD+  R+  +
Sbjct: 1481 AAVRADAETRLAEV 1494



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 142/682 (20%), Positives = 290/682 (42%), Gaps = 79/682 (11%)

Query: 1337 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV------HHVIEECKQE 1390
            E+V+Q  DC ++   ++ +    +G  + L Q + E +  V S       H    EC   
Sbjct: 25   EAVLQLQDCSIFIKIIDRIHGTEEGQQI-LKQPVSERLDFVCSFLQKNRKHPSSPECLVS 83

Query: 1391 NQ-YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE-ENTTLLGFQDKHFQHQ 1448
             Q  LEG+   LE  K   +   H T+ +   R   Q +  ++ E   +L F   H    
Sbjct: 84   AQKVLEGSE--LELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGL 141

Query: 1449 ATIAELE--LEKT------------KLQELTRKLKERVTILVKQKDVLSH-------GEK 1487
                +LE  L+K             +L   + + K  +  L  QK   S        G  
Sbjct: 142  NLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSP 201

Query: 1488 EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTL 1547
               +  ++   Q     +++++   R   ++L+ E +  R  +T  + + ++   ++  L
Sbjct: 202  ASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRL 261

Query: 1548 NGSQEEMW------QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1601
                E+        ++ E ++ +N ++   +    KQ  +LK +  Q+D +  +LS++N 
Sbjct: 262  ALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG 321

Query: 1602 QNQEKLQELNQRLTEM--LCQKEKEPGNSALEEREQEKFNLKEEL------ERCKVQSST 1653
                KL+E    L ++     +  E  + A +E  +++  L++EL      ++C  + + 
Sbjct: 322  DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381

Query: 1654 L----VSSLEAELSEVKIQTHIVQQENHLLKD--ELEKMKQLHRCPDLSDFQQKISSVLS 1707
            +    +S LE  LS+  +Q +  Q++  +L D  +LE +KQ       ++ Q +    + 
Sbjct: 382  ILQGKLSQLEEHLSQ--LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML 439

Query: 1708 YNEKLLKEKEALSEELNSCVDKLAKSSL---LEHRIATMKQEQKSWEHQS----ASLKSQ 1760
              E+  +E + L+E  +   +K   SSL   L+  I+ + Q ++  E  S    A L +Q
Sbjct: 440  ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499

Query: 1761 LVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAP 1820
            + +   ++  L  T+Q  + +++ +K      QQ KE   Q   +L +Q Q + G     
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLK------QQAKEKQAQLAQTLQQQEQASQG--LRH 551

Query: 1821 EIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN-ERLQTMVQNTKAELTHSREKVRQ 1879
            ++    S L  ++++L        + E+Q+   Q++ ++L T  +  +A L      ++Q
Sbjct: 552  QVEQLSSSLKQKEQQLK------EVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ 605

Query: 1880 LESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETI 1939
            LE+    K  K       +    + + S +    Q Q+E++  +RKV ++ +    +ET 
Sbjct: 606  LEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQAC---VETA 662

Query: 1940 HLENEGLKKKQVKLDEQLMEMQ 1961
              E    + +  +L+ QL   Q
Sbjct: 663  RQEQHEAQAQVAELELQLRSEQ 684


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  157 bits (397), Expect = 1e-37
 Identities = 241/1117 (21%), Positives = 485/1117 (43%), Gaps = 191/1117 (17%)

Query: 337  INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLD-KAEK 395
            + + E  LA EN L  T+    Q+ L + K +++  L+   ++  E E+LR+ L  K ++
Sbjct: 855  VKVREKQLAAENRL--TEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQE 912

Query: 396  LKSLMASEVDDHHAAIERRNE--YNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRL 453
            L+ +      D  A +E   E   +L+   ++ ++ I  L+ +L +E E   Q+   +++
Sbjct: 913  LEEIC----HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE-ESARQKLQLEKV 967

Query: 454  ELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLA 513
              E +++K + E+  + D+     KE   LE+ + E    L E E  +  L + L+N   
Sbjct: 968  TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-LKNKHE 1026

Query: 514  EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQ----GRVLR 569
                DL+        Q + L + R + E     L DQ+ ELQ+++ E + Q       L+
Sbjct: 1027 AMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086

Query: 570  LPLKNSPSEEVEAN----------SGGIEPEHGLGSEECN-------------------- 599
              L     E  + N          S   E +  L SE  +                    
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146

Query: 600  PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 659
             L  ++++    ++++ +  +++  L+  LE++ + +E Q+ E      +A E + ++ E
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206

Query: 660  NETHT---LEKQISDLKNEIAELQGQAAVLKEAHHEATCRH---EEEKKQLQVKLEEE-- 711
                    LEK    L+NE  EL  +  VL +   ++  +    E + ++LQVK  E   
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266

Query: 712  -KTHLQEKL-RLQHEME-----------LKARLTQAQASFEREREGLQSSAWTEEKVR-G 757
             +T L +K+ +LQ E++             ++LT+  ++ E + +  Q     E + +  
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKH----QRELQEGREKMETE--CNRRT 811
            L+ +L+Q   E+ +    +  LE+EE  K  LEK       ++ + ++KME    C    
Sbjct: 1327 LSTKLKQVEDEKNSF---REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA 1383

Query: 812  SQIEAQFQSDCQKVTERCESA------LQSLEGRYRQELKDLQ---EQQRE-----EKSQ 857
             +++ + Q D + +++R E        L+  + R +QEL DL    + QR+     EK Q
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443

Query: 858  WEF-----EKDELTQECAEAQELLKETLKREKTTSLVLTQ----------EREMLEKTY- 901
             +F     E+  ++ + AE ++  +   + ++T +L L +          E E L K + 
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503

Query: 902  -----------------------KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL 938
                                   K  L   V E +  L++LED    +E  +  L   + 
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563

Query: 939  ELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH---- 994
             +K+  +R+L+ R+E   Q+   ++   +++  +E E + ER++    + A + +     
Sbjct: 1564 AMKAQFERDLQGRDE---QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620

Query: 995  --KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSL 1052
              +A  ++A++ R E   ++ +LQ+++K+  +        +   +++ + +       S+
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE--EILAQAKENEKKLKSM 1678

Query: 1053 LQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQ-------QRLQKLEPGLVMS 1105
              +  QL EE    L + +RA  QA +E  ++A EI+          +  ++LE  +   
Sbjct: 1679 EAEMIQLQEE----LAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQ- 1733

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQ- 1164
              L+E   E  GNT       L  +R K+          ++L+ D++    +   S  Q 
Sbjct: 1734 --LEEELEEEQGNTE------LINDRLKK----------ANLQIDQINTDLNLERSHAQK 1775

Query: 1165 ----RQEVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLMMLCADCDRAS 1218
                RQ+++ +  E  V+   E+E + +++ ++    L+ +I+QL+EQL       D  +
Sbjct: 1776 NENARQQLERQNKELKVK-LQEMEGTVKSKYKASITALEAKIAQLEEQL-------DNET 1827

Query: 1219 EKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALE 1278
            +++Q     V   +KKLK +    +   +    Y+D   + D     L+ ++ + +EA E
Sbjct: 1828 KERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD---QADKASTRLKQLKRQLEEAEE 1884

Query: 1279 NNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVK 1315
              +   A   +LQ EL   E+ TET  ++ +    +K
Sbjct: 1885 EAQRANASRRKLQREL---EDATETADAMNREVSSLK 1918



 Score =  153 bits (386), Expect = 2e-36
 Identities = 241/1117 (21%), Positives = 472/1117 (42%), Gaps = 202/1117 (18%)

Query: 427  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
            +E + A + EL K RE+  Q A + RL   + ++     E        L L+E  + E E
Sbjct: 844  EEEMMAKEEELVKVREK--QLAAENRLTEMETLQSQLMAEK-------LQLQEQLQAETE 894

Query: 487  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 546
            L   AE+L     LT K Q      L E   DL+    E   +EER   ++ E ++    
Sbjct: 895  LCAEAEELRA--RLTAKKQE-----LEEICHDLEARVEE---EEERCQHLQAEKKK---- 940

Query: 547  LQDQVDELQSELEEYRAQGRVLRLP-------LKNSPSEEV--EANSGGIEPEHGLGSEE 597
            +Q  + EL+ +LEE  +  + L+L        LK    E++  E  +  +  E  L  + 
Sbjct: 941  MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000

Query: 598  CNPLNMSI----EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQEN 653
                  ++    E    + ++K +H   I     +LE+++R  EKQ  E         E 
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMIT----DLEERLRREEKQRQEL--------EK 1048

Query: 654  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV------K 707
             +++ E ++  L  QI++L+ +IAEL+ Q A  +E    A  R EEE  Q  +      +
Sbjct: 1049 TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108

Query: 708  LEEEKTHLQEKLRLQHEM-------------ELKARLTQAQASFEREREGLQSSAWTEEK 754
            LE + + LQE L  +                EL+A  T+ + + +      +  +  E++
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168

Query: 755  VRGLTQELEQ---FHQEQLTSLVEKHTLEKEELRKEL--LEKHQRELQEGREKMETECNR 809
            V  L + LE+    H+ Q+  + +KH+   EEL ++L   ++ +  L++ ++ +E E   
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228

Query: 810  RTSQIEA--QFQSDCQKVTERCESALQSLE------GRYRQELKD--------------L 847
              ++++   Q + D +   ++ E+ LQ L+       R R EL D              L
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288

Query: 848  QEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNS 907
              Q   + S+   +   L  +  + QELL+E  +++ + S  L Q  +  + +++E L  
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE-KNSFREQLEE 1347

Query: 908  MVVERQQLLQDLEDLRNVSETQQSLLSDQI--LELKSSHKRELREREEVLCQAGASEQLA 965
                +  L + +  L       +  + D +  LE     KR+L++  E L Q    +  A
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA 1407

Query: 966  SQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRER-------------AEMSTEI 1012
              +LE+ +    QE  ++   L+ +++  ++ C    +++             A+ + E 
Sbjct: 1408 YDKLEKTKTRLQQELDDL---LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464

Query: 1013 SRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQ-----QGEQLLEENGDV- 1066
             R +++ +E +  T  LS+ ++      EE +E    L  L      + E L+    DV 
Sbjct: 1465 DRAEAEAREKE--TKALSLARA-----LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVG 1517

Query: 1067 -----LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE 1121
                 L   +RA EQ V+E   M T++  L+  LQ  E   +      +     F    +
Sbjct: 1518 KSVHELEKSKRALEQQVEE---MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574

Query: 1122 QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1181
              +   ++ + + V  V  R + ++LED+  R   S   ++ ++ E+ +++ EA      
Sbjct: 1575 GRDEQSEEKKKQLVRQV--REMEAELEDE--RKQRSMAVAARKKLEMDLKDLEA------ 1624

Query: 1182 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE-- 1239
             ++++ + R E+ +   Q+ +LQ Q+     + D     ++++L      +KKLK +E  
Sbjct: 1625 HIDSANKNRDEAIK---QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE 1681

Query: 1240 --RIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1297
              ++ E     +       +E D L +E+     +   ALE  + L A + +L++EL++ 
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741

Query: 1298 EEVTE-----------------TFLSLEKSY--------DEVKIENEELNVLVLRLQGKI 1332
            +  TE                 T L+LE+S+         +++ +N+EL V +  ++G +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV 1801

Query: 1333 -------------------EKLQESVVQRCDCC----LWEASLENLEIEPDG---NILQL 1366
                               E+L     +R   C      E  L+++ ++ D    N  Q 
Sbjct: 1802 KSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861

Query: 1367 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEK 1403
                ++   R++ +   +EE ++E Q    + + L++
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898



 Score =  141 bits (355), Expect = 7e-33
 Identities = 230/1020 (22%), Positives = 447/1020 (43%), Gaps = 181/1020 (17%)

Query: 307  VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 366
            +E++    + + +E  Q IL+  +  L     L E  +A E    +T+      +LA  K
Sbjct: 964  LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA-EFTTNLTEEEEKSKSLAKLK 1022

Query: 367  AEIRHLLERVDQVVREKEKLRSDLDKAEK----------------------LKSLMASEV 404
             +   ++  +++ +R +EK R +L+K  +                      LK  +A + 
Sbjct: 1023 NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082

Query: 405  DDHHAAIERRNE------YNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQE 458
            ++  AA+ R  E        L+K+  E + +I+ L+ +L  ER     +A KQ+ +L +E
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKI-RELESQISELQEDLESERAS-RNKAEKQKRDLGEE 1140

Query: 459  IEKAKTEENYIRDRLALSLKENSRLENEL-------------------------LENAEK 493
            +E  KTE     D  A   +  S+ E E+                          +  E+
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200

Query: 494  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 553
            LAE    T +++ NLE         L+    E   + + L Q + + E + + ++ Q+ E
Sbjct: 1201 LAEQLEQTKRVKANLEKAKQ----TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE 1256

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSE-EVEA-NSGGIEPEHGLGSEECNPLNMSIEAELV- 610
            LQ +  E    G  +R  L +  ++ +VE  N  G+  +    S +      ++E++L  
Sbjct: 1257 LQVKFNE----GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312

Query: 611  IEQMKEQHHRDICCLRLEL---EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEK 667
             +++ ++ +R    L  +L   ED+   + +QL+E        +E  K   E +  TL  
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE--------EEEAKHNLEKQIATLHA 1364

Query: 668  QISDLKNEIAELQGQAAVLKEAHH------EATCRHEEEKKQLQVKLEEEKTHLQEKL-- 719
            Q++D+K ++ +  G     +E         E   +  EEK     KLE+ KT LQ++L  
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424

Query: 720  ---RLQHEMELKARLTQAQASFER--------------EREGLQSSAWTEE-KVRGLTQE 761
                L H+ +    L + Q  F++              ER+  ++ A  +E K   L + 
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484

Query: 762  LEQFHQE--QLTSLVEKHTLEKEEL--RKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            LE+  ++  +L  L ++   E E+L   K+ + K   EL++ +  +E +     +Q+E +
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE-E 1543

Query: 818  FQSDCQKVTE---RCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 874
             + + Q   +   R E  LQ+++ ++ ++L+   EQ  E+K Q       L ++  E + 
Sbjct: 1544 LEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ-------LVRQVREMEA 1596

Query: 875  LLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLS 934
             L++  +++++ ++   ++ EM  K  + H++S    R + ++ L  L       Q+ + 
Sbjct: 1597 ELEDE-RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL-------QAQMK 1648

Query: 935  DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 994
            D + EL  +       REE+L QA  +E    ++L+ +E E  Q ++E    L A E   
Sbjct: 1649 DCMRELDDTR----ASREEILAQAKENE----KKLKSMEAEMIQLQEE----LAAAERAK 1696

Query: 995  KATCETADRERAEMSTEISRLQSK----IKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL 1050
            +     A +ER E++ EI+    K    ++E ++  + ++ L+        EE +G+  L
Sbjct: 1697 R----QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL-----EEEQGNTEL 1747

Query: 1051 ---SLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATE--ISRLQQRLQKLEPGLVMS 1105
                L +   Q+ + N D  L+L+R+H Q   EN +   E     L+ +LQ++E G V S
Sbjct: 1748 INDRLKKANLQIDQINTD--LNLERSHAQK-NENARQQLERQNKELKVKLQEME-GTVKS 1803

Query: 1106 ------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR--RHVLSDLEDD------- 1150
                  + L+    +       +T+   +Q   KQV    +  + VL  ++D+       
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKE--RQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861

Query: 1151 -EVRDLGSTGTSSVQRQ-EVKIEESEASVEGFSELENSEETRTESWELKN-QISQLQEQL 1207
             +  D  ST    ++RQ E   EE++ +     +L+   E  TE+ +  N ++S L+ +L
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score =  111 bits (277), Expect = 8e-24
 Identities = 248/1220 (20%), Positives = 478/1220 (39%), Gaps = 242/1220 (19%)

Query: 867  QECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS 926
            Q C       K   KR++  + +     ++L++    +L     +  +L   ++ L  VS
Sbjct: 787  QACCRGYLARKAFAKRQQQLTAM-----KVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVS 841

Query: 927  ETQQSLLSDQ-----ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 981
              ++ +++ +     + E + + +  L E E +  Q  A E+L  Q   + E E   E +
Sbjct: 842  RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQAETELCAEAE 900

Query: 982  EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSML----QSGCQ 1037
            E+ ++L A +   +  C   +    E       LQ++ K+MQQ    L       +S  Q
Sbjct: 901  ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 960

Query: 1038 VIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK 1097
             +  E+V  +  L  L++ + +LE+                 +N K+A E   L+ R+  
Sbjct: 961  KLQLEKVTTEAKLKKLEEEQIILED-----------------QNCKLAKEKKLLEDRI-- 1001

Query: 1098 LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH--VLSDLEDDEVRDL 1155
                            EF  N  E+ E      ++K +  +  +H  +++DLE+   R+ 
Sbjct: 1002 ---------------AEFTTNLTEEEE------KSKSLAKLKNKHEAMITDLEERLRRE- 1039

Query: 1156 GSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCD 1215
                    ++Q  ++E++   +EG            +S +L +QI++LQ Q+  L     
Sbjct: 1040 --------EKQRQELEKTRRKLEG------------DSTDLSDQIAELQAQIAELKMQLA 1079

Query: 1216 RASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
            +  E+ Q  L  V     +  M      A  K + L   +S     LQE+L       ++
Sbjct: 1080 KKEEELQAALARVEEEAAQKNM------ALKKIRELESQISE----LQEDLESERASRNK 1129

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKL 1335
            A +  ++L  E+  L+ EL+   + T     L    ++      E+N+L   L+ + +  
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ------EVNILKKTLEEEAKT- 1182

Query: 1336 QESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLE 1395
                         EA ++ +  +    + +L + LE+     + V   +E+ KQ  +   
Sbjct: 1183 ------------HEAQIQEMRQKHSQAVEELAEQLEQ----TKRVKANLEKAKQTLENER 1226

Query: 1396 GNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELE 1455
            G  +L  +VK      L G   +  +R +V+ Q        L   Q K  + +    EL 
Sbjct: 1227 G--ELANEVKV----LLQGKGDSEHKRKKVEAQ--------LQELQVKFNEGERVRTELA 1272

Query: 1456 LEKTKLQ-ELTRKLKERVTILVKQKDVLSHGEKEE--ELKAMMHDLQITCSEMQQKVELL 1512
             + TKLQ EL     + VT L+ Q D  S    ++   L++ + D Q    E  ++   L
Sbjct: 1273 DKVTKLQVEL-----DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNLK--LGTLNGSQEEMWQKTE-------TVKQ 1563
              + ++++ E +  R ++    EE++  NL+  + TL+    +M +K E       T ++
Sbjct: 1328 STKLKQVEDEKNSFREQLE--EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385

Query: 1564 ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQK----------NSQNQEKLQELNQR 1613
                +QK +E L ++  E      +L+   T L Q+            Q+   L++  ++
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445

Query: 1614 LTEMLCQ-------------------KEKEPGNSALEEREQEKFNLKEELERCKVQSSTL 1654
              ++L +                   +EKE    +L    +E    K ELER   Q  T 
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505

Query: 1655 VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLK 1714
            +  L +   +V    H +++    L+ ++E+MK                           
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK--------------------------T 1539

Query: 1715 EKEALSEELNSCVD-KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLED 1773
            + E L +EL +  D KL     L+   A  +++ +  + QS   K QLV    +V+ +E 
Sbjct: 1540 QLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLV---RQVREMEA 1596

Query: 1774 TVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQ 1833
             +++   Q S   +  +  + + + L+  + S +K            E       L  Q 
Sbjct: 1597 ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN---------RDEAIKQLRKLQAQM 1647

Query: 1834 KRLSWDKLDHLMNEEQQLLWQ--ENER----LQTMVQNTKAELTHSREKVRQLESNLLPK 1887
            K     +LD      +++L Q  ENE+    ++  +   + EL  +    RQ +      
Sbjct: 1648 KD-CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK 1947
              +  N SG      +EK  L+    Q ++E             LE+E     L N+ LK
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEE-------------LEEEQGNTELINDRLK 1753

Query: 1948 KKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQ------LQRQL 2001
            K  +++D+   ++   RS A  + +      Q L++Q   +  + Q ++       +  +
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENAR----QQLERQNKELKVKLQEMEGTVKSKYKASI 1809

Query: 2002 LQAERINQHLQEELENRTSE 2021
               E     L+E+L+N T E
Sbjct: 1810 TALEAKIAQLEEQLDNETKE 1829


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  157 bits (396), Expect = 1e-37
 Identities = 226/1143 (19%), Positives = 502/1143 (43%), Gaps = 120/1143 (10%)

Query: 754  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
            KV+ L Q   Q  + Q     ++  L+K + R++  E   +EL++   ++  E N    Q
Sbjct: 840  KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 814  IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 871
            ++A+ +  ++ +++  R  +  Q LE     E++   E++ +   Q + E+ ++ Q+  +
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954

Query: 872  AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 924
             +E L+E       L+ EK T+    ++ E       +  N +  ER+ L + + DL  N
Sbjct: 955  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014

Query: 925  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 984
            ++E ++   +  + +LK+ H+  + E E  L      E+ + Q LE+L+ + + +  +  
Sbjct: 1015 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 985  SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1043
             ++  ++  I +   + A +E  E+   ++RL  +I +   A   +  L+     I + +
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1124

Query: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
             + D   +   + E+   + G+ L +L+   E  +          ++ + R ++ +   V
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1178

Query: 1104 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1156
            +   LDE          E  +   Q  +  T+Q+E   R     D     LE +     G
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238

Query: 1157 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1213
                    +QEV  K ++ EA V+   S+  + E  R    EL +++ +LQ ++  +   
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1295

Query: 1214 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1273
             + A  K   L  DV+ L  +L+  + + +   + KL   +VS +   L+EE   ++ + 
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1352

Query: 1274 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1326
            DE +E  + L   +     +L D  KK+++   T  +LE+     + E E L        
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412

Query: 1327 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1384
                K+EK +  + Q  D  +    L+N + +   N+ +  +  ++ +   +++   +  
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 1385 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1443
            E  + E +  E  T+ L   +A E A     ++  +E  R  N+++  E   L+  +D  
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1523

Query: 1444 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1484
                       +A   ++E  KT+L+EL      T   K R+ + ++      ++D+ + 
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583

Query: 1485 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1538
             E+ EE    L+  +H+ +    + +++  L     +KL+ +  +  L+ +      E++
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643

Query: 1539 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1586
            I  L+            L     S++E++   +  +++  +++  +  L++ ++  +   
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703

Query: 1587 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1643
            +Q DLE  EL+++   +   +  LQ+  +RL   + Q E+E     LEE +     + + 
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1758

Query: 1644 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1697
            + +   Q+  L + L  E S  +      QQ   +N  L+ +L +M+   +      ++ 
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1757
             + KI+ +    E+  +EK+A ++ L    DK  K  LL+  +   ++  + ++ Q+   
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1875

Query: 1758 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1817
             +++   + +++  E+  Q +N    +++ +L    +  EA+ +EV +L  +L+     S
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935

Query: 1818 WAP 1820
            + P
Sbjct: 1936 FVP 1938



 Score =  149 bits (377), Expect = 2e-35
 Identities = 252/1230 (20%), Positives = 513/1230 (41%), Gaps = 166/1230 (13%)

Query: 427  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
            +E + A ++EL+K +E+  Q+A  +  ELEQ+  +   E+N ++++L    +  +  E  
Sbjct: 851  EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909

Query: 487  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 546
             +  A K  E E + ++++  LE                   +E+R  Q++ E ++  + 
Sbjct: 910  RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 951

Query: 547  LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 606
            + D    L+ +LEE  A  + L+L    +     EA    +E E  +  ++ N L+    
Sbjct: 952  MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1000

Query: 607  AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 653
                  ++ E+   D+     E E+K ++       +E  + E  V  KK +      E 
Sbjct: 1001 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055

Query: 654  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 713
            +K++ E +     +QI+DL+ +IAEL+ Q A  +E    A  R ++E  Q        K 
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1107

Query: 714  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 773
            +  +K+R     EL+  ++  Q   + ER     +   E++ R L +ELE    E     
Sbjct: 1108 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1155

Query: 774  VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 833
              + TL+    ++EL  K ++E+   ++ ++ E     +Q++   Q   Q V E  E   
Sbjct: 1156 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1212

Query: 834  QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
                    ++ K  +    + K   E E  +L  E     +  +E   ++K       Q 
Sbjct: 1213 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1261

Query: 894  REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 948
            +E+  K       +  LN  V + Q  ++ +  + N +E +   L+  +  L S    +L
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1317

Query: 949  REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1008
            ++ +E+L +    +   S +L +LE E +  + ++  ++ A +N+ +            +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1366

Query: 1009 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
            ST   +L    K++Q   S +  L+ G +   ++E+E     +L QQ     EE      
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1416

Query: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1128
             L++   +  +E   +  ++   +Q +  LE        L           A++ +    
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476

Query: 1129 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1187
            + R K+ + ++    L + LE  E  +L  T        E  +   +   +   ELE S+
Sbjct: 1477 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534

Query: 1188 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1238
                T+  E+K Q+ +L+++L       L  + +  + K Q   DL       ++K + L
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594

Query: 1239 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1291
            +R      +Y+   ED  ++          L+ +L+ +E + D A++  +E   ++ +LQ
Sbjct: 1595 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651

Query: 1292 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1351
             ++K  +   E       S DE+    +E       L+  + +LQE +    +    +A 
Sbjct: 1652 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1707

Query: 1352 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1405
            LE  E+ E   + L     L++   R+ + +  + EE ++E   +E  +  + K      
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767

Query: 1406 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1460
              ++E+A    T Q ++   ++   QN+ +  +   + G     F  ++TIA LE +  +
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1825

Query: 1461 LQELTR---KLKERVTILVKQKD-----VLSHGEKE----EELKAMMHDLQITCSEMQQK 1508
            L+E      + K+  T  +KQKD     +L   E E    E+ K           +++++
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885

Query: 1509 VELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAV 1568
            +E    ES+++      L+ E+    E +     ++  L  S+     +T  V    +  
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK-SKLRRGNETSFVPSRRSGG 1944

Query: 1569 QKMVENLKKQISELKIKNQQLDLENTELSQ 1598
            ++++EN     SE +   +  D   T+ S+
Sbjct: 1945 RRVIENADG--SEEETDTRDADFNGTKASE 1972



 Score =  148 bits (374), Expect = 5e-35
 Identities = 253/1137 (22%), Positives = 493/1137 (43%), Gaps = 201/1137 (17%)

Query: 345  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 404
            A E+EL  TK    +A     + E++ L ++  Q+  EK  L+  L    +L +  A E+
Sbjct: 856  AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 909

Query: 405  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 453
                AA ++  E  L +++   EE ++R   L+ E +K  +Q+L        ++A +Q+L
Sbjct: 910  RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969

Query: 454  ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 502
            +LE+   +AK ++  + D + +   +N++L  E +LLE          AE+  + +NLT 
Sbjct: 970  QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1026

Query: 503  KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 558
            KL+   E++++E   +    + S  E    + +L    +++  Q   LQ Q+ EL+ +L 
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 559  -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 598
             +E   Q  + RL      KN+  +++    G I + +  L SE                
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 599  ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 652
                    L  ++++    ++++ +  +++  L+  L+++ R +E Q+ E      +A E
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206

Query: 653  NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
             + ++ E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1262

Query: 710  E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 747
            E           +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q 
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322

Query: 748  SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
                E + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 807  CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 851
                 S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 852  RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 889
            R+     EK Q +F++             DE  +  AEA+E  KET    L R    +L 
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1497

Query: 890  LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 946
              +E E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1553

Query: 947  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1006
            EL+  E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613

Query: 1007 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1066
              +    +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D 
Sbjct: 1614 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1657

Query: 1067 LLSLQRAHEQ------AVKENVKMA----TEISRLQQRLQKLE-----PGLVMSSCLDEP 1111
               L+ A           KEN K A     ++ +LQ+ L   E       L      +E 
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717

Query: 1112 ATEFFGNTAEQTEPFLQQNRTKQ-----------VEGVTRRHVLSDLEDDEVRDLGSTGT 1160
            A+   G  A Q E    + R  Q           +E ++ R   +  + +++ +  +T  
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777

Query: 1161 SSVQRQEVKIEESEASVE----GFSELENSEETRTESW--ELKNQISQLQEQLMMLCADC 1214
            S+ Q+ E   ++ E   +       E+E + +++ +S    L+ +I+QL+EQ+     + 
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837

Query: 1215 DRAS----EKKQDLLFDVSVLKKKLKMLERIPEASPK-------YKLLYEDVSRENDCLQ 1263
              A+    +K + L   +  ++ + KM E+  E + K        K   E+   E+  + 
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897

Query: 1264 EELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
               R ++   DEA E+N+ +  EV  L+ +L++  E   +F+   +S     IEN +
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET--SFVPSRRSGGRRVIENAD 1952



 Score =  139 bits (351), Expect = 2e-32
 Identities = 242/1182 (20%), Positives = 493/1182 (41%), Gaps = 146/1182 (12%)

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 613
            LQ   +E   Q +   L       ++ E     +E +H   +EE N L   ++AE  +  
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 614  MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 673
              E+    +   + ELE+ +   E +L+E        +E+  Q+ + E   + +Q+ DL+
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 956

Query: 674  NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 733
             ++ E +     L+     A  + ++ + ++ V ++++   L ++ +L     L+ R++ 
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1010

Query: 734  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 793
               +   E          EEK + LT +L+  H+  ++ L  +  L+KEE  ++ LEK +
Sbjct: 1011 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1057

Query: 794  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 853
            R+L+        +     +QI A+ +    K  E  ++AL  L+    Q+   L++ +  
Sbjct: 1058 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1116

Query: 854  EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 911
            E    + ++D  ++  A  +    E  KR+      L +E E L+   ++ L+S   +  
Sbjct: 1117 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1167

Query: 912  -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 970
             R +  Q++  L+   + +      Q+ E++  H + + E  E L Q   ++    +  +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227

Query: 971  RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1017
             LE E+              QE +    KL A     ++ C   +R RAE++ ++ +LQ+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287

Query: 1018 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1062
            +               IK  +   S  S LQ   +++ EE  +     + L+Q E+  E 
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1345

Query: 1063 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
            N    L  Q   E   K+N++  ++T   +L    +KL+        L+E    F     
Sbjct: 1346 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402

Query: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1178
              T+ + ++         T+  +  +L DD V DL +     S++++++ K ++  A  +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461

Query: 1179 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1238
              S     E  R E+     +  + + + + L    + A E K++L     +LK +++ L
Sbjct: 1462 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 1239 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1298
                  S K     +DV +    L++  R +ET+ +E     +EL  E+   +D   ++E
Sbjct: 1517 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 1299 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1352
               +      E+       +NEE    + R   + E +L++   QR          E  L
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 1353 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1412
            ++LE++ D  I    +  EE + ++R +   +++ ++E          LE  +A     +
Sbjct: 1627 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1671

Query: 1413 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1471
              T + ++++ +            L+  Q+     +    + +LEK +L +EL   L  R
Sbjct: 1672 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724

Query: 1472 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1531
              +           +++  L+A +  L+    E Q  +E +     K  Q+   L NE+ 
Sbjct: 1725 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774

Query: 1532 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1591
            T       +      L    +E+  K    + E A   K     K  I+ L+ K  QL+ 
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1828

Query: 1592 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1646
            +  + +++     + L++ +++L E+L Q E E   +   + + EK N     LK +LE 
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888

Query: 1647 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDELEK 1685
             + +S  + ++   L+ EL E       + +E + LK +L +
Sbjct: 1889 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930



 Score =  104 bits (260), Expect = 8e-22
 Identities = 176/852 (20%), Positives = 359/852 (42%), Gaps = 136/852 (15%)

Query: 1236 KMLERIPEASPKYKLL---YEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQD 1292
            K  ER  +A  + K L   +  ++ E + LQE+L+     Y EA E    L A+   L++
Sbjct: 863  KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922

Query: 1293 ELKKME------------------EVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEK 1334
             L +ME                  ++ +  L LE+  +E +   ++L +  +  + KI+K
Sbjct: 923  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982

Query: 1335 LQESVVQRCDCCLWEASLENLEIEPDGNILQ-----LNQTLEECVPRVRSVHHVIEECKQ 1389
            L++ ++   D        +N ++  +  +L+     L   L E   + +++       K 
Sbjct: 983  LEDEILVMDD--------QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL------TKL 1028

Query: 1390 ENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQA 1449
            +N++    ++L  ++K  E        ++ QE  +++ +  LE + +   F ++    QA
Sbjct: 1029 KNKHESMISELEVRLKKEE--------KSRQELEKLKRK--LEGDAS--DFHEQIADLQA 1076

Query: 1450 TIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKV 1509
             IAEL+++      L +K +E    L +  D ++  +K   LK +  +L+   S++Q+ +
Sbjct: 1077 QIAELKMQ------LAKKEEELQAALARLDDEIA--QKNNALKKI-RELEGHISDLQEDL 1127

Query: 1510 ELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1569
            +  R    K +++   L  E+  L  E               E+    T T ++  A  +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTE--------------LEDTLDSTATQQELRAKRE 1173

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK-----E 1624
            + V  LKK + E   + +  + +  E+ QK++Q  E+L E  ++        +K     E
Sbjct: 1174 QEVTVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230

Query: 1625 PGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELE 1684
              N+ L    +     K+E+E  K +    V  L+++ S+ +     +  + H L++E+E
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290

Query: 1685 KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMK 1744
             +  +     L++ + K         KL K+  +LS +L    + L + +  +  ++T  
Sbjct: 1291 SVTGM-----LNEAEGKAI-------KLAKDVASLSSQLQDTQELLQEETRQKLNVST-- 1336

Query: 1745 QEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVM 1804
             + +  E +  SL+ QL    E  QNLE  +  +N+Q+S  K  L+      EAL++   
Sbjct: 1337 -KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 1805 SLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQ 1864
               K+++N   +               ++K  ++DKL+   N     L QE + L   + 
Sbjct: 1396 RFQKEIENLTQQ--------------YEEKAAAYDKLEKTKNR----LQQELDDLVVDLD 1437

Query: 1865 NTKAELTHSREKVRQL------ESNLLPKH-QKHLNPSGTMNPTEQEKLSLKRECDQF-- 1915
            N +  +++  +K R+       E N+  K+  +           E + LSL R  ++   
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497

Query: 1916 QKEQSPANRKV--SQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1973
             KE+     K+  ++M  L    + +      L+K +  L+ Q+ EM+            
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1553

Query: 1974 HAWDLQLLQQQACPMVPREQFL--QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
               +LQ  +     +    Q L  Q +R L   +  N+  + +L+ +  E  T      +
Sbjct: 1554 ---ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610

Query: 2032 QRAVHADSYRRI 2043
            QRA+ A + +++
Sbjct: 1611 QRALAAAAKKKL 1622



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 57/277 (20%), Positives = 111/277 (40%), Gaps = 39/277 (14%)

Query: 323  QEILKALDFSLDGNINLTELTLALENELLVTKNSIH--QAALASFKAEIRHLLERVDQVV 380
            +E+ + L  SL G   L +    LE  +   +  +   Q  + +    +R   ++ +Q+ 
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770

Query: 381  REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE-------EYKERIAAL 433
             E    RS   K E  +             +ER+N+    KL E       ++K  IAAL
Sbjct: 1771 NELATERSTAQKNESARQ-----------QLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 434  KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 493
            + ++ +  EQ+ Q+A +     +Q   K+  +++     + L +++  ++  +  E AEK
Sbjct: 1820 EAKIAQLEEQVEQEARE-----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874

Query: 494  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 553
                     +L+R LE        + +  S        +L +  +E       +  +V+ 
Sbjct: 1875 ---GNARVKQLKRQLE--------EAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
            L+S+L   R       +P + S    V  N+ G E E
Sbjct: 1924 LKSKL---RRGNETSFVPSRRSGGRRVIENADGSEEE 1957


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  157 bits (396), Expect = 1e-37
 Identities = 226/1143 (19%), Positives = 502/1143 (43%), Gaps = 120/1143 (10%)

Query: 754  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
            KV+ L Q   Q  + Q     ++  L+K + R++  E   +EL++   ++  E N    Q
Sbjct: 847  KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 814  IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 871
            ++A+ +  ++ +++  R  +  Q LE     E++   E++ +   Q + E+ ++ Q+  +
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961

Query: 872  AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 924
             +E L+E       L+ EK T+    ++ E       +  N +  ER+ L + + DL  N
Sbjct: 962  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021

Query: 925  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 984
            ++E ++   +  + +LK+ H+  + E E  L      E+ + Q LE+L+ + + +  +  
Sbjct: 1022 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 985  SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1043
             ++  ++  I +   + A +E  E+   ++RL  +I +   A   +  L+     I + +
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1131

Query: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
             + D   +   + E+   + G+ L +L+   E  +          ++ + R ++ +   V
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1185

Query: 1104 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1156
            +   LDE          E  +   Q  +  T+Q+E   R     D     LE +     G
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245

Query: 1157 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1213
                    +QEV  K ++ EA V+   S+  + E  R    EL +++ +LQ ++  +   
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1302

Query: 1214 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1273
             + A  K   L  DV+ L  +L+  + + +   + KL   +VS +   L+EE   ++ + 
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1359

Query: 1274 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1326
            DE +E  + L   +     +L D  KK+++   T  +LE+     + E E L        
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419

Query: 1327 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1384
                K+EK +  + Q  D  +    L+N + +   N+ +  +  ++ +   +++   +  
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 1385 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1443
            E  + E +  E  T+ L   +A E A     ++  +E  R  N+++  E   L+  +D  
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1530

Query: 1444 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1484
                       +A   ++E  KT+L+EL      T   K R+ + ++      ++D+ + 
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590

Query: 1485 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1538
             E+ EE    L+  +H+ +    + +++  L     +KL+ +  +  L+ +      E++
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 1539 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1586
            I  L+            L     S++E++   +  +++  +++  +  L++ ++  +   
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710

Query: 1587 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1643
            +Q DLE  EL+++   +   +  LQ+  +RL   + Q E+E     LEE +     + + 
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1765

Query: 1644 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1697
            + +   Q+  L + L  E S  +      QQ   +N  L+ +L +M+   +      ++ 
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1757
             + KI+ +    E+  +EK+A ++ L    DK  K  LL+  +   ++  + ++ Q+   
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1882

Query: 1758 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1817
             +++   + +++  E+  Q +N    +++ +L    +  EA+ +EV +L  +L+     S
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942

Query: 1818 WAP 1820
            + P
Sbjct: 1943 FVP 1945



 Score =  149 bits (377), Expect = 2e-35
 Identities = 252/1230 (20%), Positives = 513/1230 (41%), Gaps = 166/1230 (13%)

Query: 427  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
            +E + A ++EL+K +E+  Q+A  +  ELEQ+  +   E+N ++++L    +  +  E  
Sbjct: 858  EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916

Query: 487  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 546
             +  A K  E E + ++++  LE                   +E+R  Q++ E ++  + 
Sbjct: 917  RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 958

Query: 547  LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 606
            + D    L+ +LEE  A  + L+L    +     EA    +E E  +  ++ N L+    
Sbjct: 959  MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1007

Query: 607  AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 653
                  ++ E+   D+     E E+K ++       +E  + E  V  KK +      E 
Sbjct: 1008 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 654  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 713
            +K++ E +     +QI+DL+ +IAEL+ Q A  +E    A  R ++E  Q        K 
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1114

Query: 714  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 773
            +  +K+R     EL+  ++  Q   + ER     +   E++ R L +ELE    E     
Sbjct: 1115 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1162

Query: 774  VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 833
              + TL+    ++EL  K ++E+   ++ ++ E     +Q++   Q   Q V E  E   
Sbjct: 1163 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219

Query: 834  QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
                    ++ K  +    + K   E E  +L  E     +  +E   ++K       Q 
Sbjct: 1220 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1268

Query: 894  REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 948
            +E+  K       +  LN  V + Q  ++ +  + N +E +   L+  +  L S    +L
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1324

Query: 949  REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1008
            ++ +E+L +    +   S +L +LE E +  + ++  ++ A +N+ +            +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1373

Query: 1009 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
            ST   +L    K++Q   S +  L+ G +   ++E+E     +L QQ     EE      
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1423

Query: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1128
             L++   +  +E   +  ++   +Q +  LE        L           A++ +    
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 1129 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1187
            + R K+ + ++    L + LE  E  +L  T        E  +   +   +   ELE S+
Sbjct: 1484 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541

Query: 1188 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1238
                T+  E+K Q+ +L+++L       L  + +  + K Q   DL       ++K + L
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601

Query: 1239 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1291
            +R      +Y+   ED  ++          L+ +L+ +E + D A++  +E   ++ +LQ
Sbjct: 1602 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658

Query: 1292 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1351
             ++K  +   E       S DE+    +E       L+  + +LQE +    +    +A 
Sbjct: 1659 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1714

Query: 1352 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1405
            LE  E+ E   + L     L++   R+ + +  + EE ++E   +E  +  + K      
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 1406 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1460
              ++E+A    T Q ++   ++   QN+ +  +   + G     F  ++TIA LE +  +
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1832

Query: 1461 LQELTR---KLKERVTILVKQKD-----VLSHGEKE----EELKAMMHDLQITCSEMQQK 1508
            L+E      + K+  T  +KQKD     +L   E E    E+ K           +++++
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892

Query: 1509 VELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAV 1568
            +E    ES+++      L+ E+    E +     ++  L  S+     +T  V    +  
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK-SKLRRGNETSFVPSRRSGG 1951

Query: 1569 QKMVENLKKQISELKIKNQQLDLENTELSQ 1598
            ++++EN     SE +   +  D   T+ S+
Sbjct: 1952 RRVIENADG--SEEETDTRDADFNGTKASE 1979



 Score =  148 bits (374), Expect = 5e-35
 Identities = 253/1137 (22%), Positives = 493/1137 (43%), Gaps = 201/1137 (17%)

Query: 345  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 404
            A E+EL  TK    +A     + E++ L ++  Q+  EK  L+  L    +L +  A E+
Sbjct: 863  AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 916

Query: 405  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 453
                AA ++  E  L +++   EE ++R   L+ E +K  +Q+L        ++A +Q+L
Sbjct: 917  RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976

Query: 454  ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 502
            +LE+   +AK ++  + D + +   +N++L  E +LLE          AE+  + +NLT 
Sbjct: 977  QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1033

Query: 503  KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 558
            KL+   E++++E   +    + S  E    + +L    +++  Q   LQ Q+ EL+ +L 
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 559  -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 598
             +E   Q  + RL      KN+  +++    G I + +  L SE                
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 599  ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 652
                    L  ++++    ++++ +  +++  L+  L+++ R +E Q+ E      +A E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213

Query: 653  NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
             + ++ E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1269

Query: 710  E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 747
            E           +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q 
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329

Query: 748  SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
                E + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 807  CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 851
                 S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 852  RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 889
            R+     EK Q +F++             DE  +  AEA+E  KET    L R    +L 
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1504

Query: 890  LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 946
              +E E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1560

Query: 947  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1006
            EL+  E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620

Query: 1007 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1066
              +    +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D 
Sbjct: 1621 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1664

Query: 1067 LLSLQRAHEQ------AVKENVKMA----TEISRLQQRLQKLE-----PGLVMSSCLDEP 1111
               L+ A           KEN K A     ++ +LQ+ L   E       L      +E 
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724

Query: 1112 ATEFFGNTAEQTEPFLQQNRTKQ-----------VEGVTRRHVLSDLEDDEVRDLGSTGT 1160
            A+   G  A Q E    + R  Q           +E ++ R   +  + +++ +  +T  
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784

Query: 1161 SSVQRQEVKIEESEASVE----GFSELENSEETRTESW--ELKNQISQLQEQLMMLCADC 1214
            S+ Q+ E   ++ E   +       E+E + +++ +S    L+ +I+QL+EQ+     + 
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844

Query: 1215 DRAS----EKKQDLLFDVSVLKKKLKMLERIPEASPK-------YKLLYEDVSRENDCLQ 1263
              A+    +K + L   +  ++ + KM E+  E + K        K   E+   E+  + 
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904

Query: 1264 EELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
               R ++   DEA E+N+ +  EV  L+ +L++  E   +F+   +S     IEN +
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET--SFVPSRRSGGRRVIENAD 1959



 Score =  139 bits (351), Expect = 2e-32
 Identities = 242/1182 (20%), Positives = 493/1182 (41%), Gaps = 146/1182 (12%)

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 613
            LQ   +E   Q +   L       ++ E     +E +H   +EE N L   ++AE  +  
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 614  MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 673
              E+    +   + ELE+ +   E +L+E        +E+  Q+ + E   + +Q+ DL+
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 963

Query: 674  NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 733
             ++ E +     L+     A  + ++ + ++ V ++++   L ++ +L     L+ R++ 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1017

Query: 734  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 793
               +   E          EEK + LT +L+  H+  ++ L  +  L+KEE  ++ LEK +
Sbjct: 1018 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1064

Query: 794  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 853
            R+L+        +     +QI A+ +    K  E  ++AL  L+    Q+   L++ +  
Sbjct: 1065 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123

Query: 854  EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 911
            E    + ++D  ++  A  +    E  KR+      L +E E L+   ++ L+S   +  
Sbjct: 1124 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1174

Query: 912  -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 970
             R +  Q++  L+   + +      Q+ E++  H + + E  E L Q   ++    +  +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234

Query: 971  RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1017
             LE E+              QE +    KL A     ++ C   +R RAE++ ++ +LQ+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294

Query: 1018 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1062
            +               IK  +   S  S LQ   +++ EE  +     + L+Q E+  E 
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1352

Query: 1063 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
            N    L  Q   E   K+N++  ++T   +L    +KL+        L+E    F     
Sbjct: 1353 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1178
              T+ + ++         T+  +  +L DD V DL +     S++++++ K ++  A  +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468

Query: 1179 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1238
              S     E  R E+     +  + + + + L    + A E K++L     +LK +++ L
Sbjct: 1469 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 1239 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1298
                  S K     +DV +    L++  R +ET+ +E     +EL  E+   +D   ++E
Sbjct: 1524 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 1299 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1352
               +      E+       +NEE    + R   + E +L++   QR          E  L
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 1353 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1412
            ++LE++ D  I    +  EE + ++R +   +++ ++E          LE  +A     +
Sbjct: 1634 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1678

Query: 1413 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1471
              T + ++++ +            L+  Q+     +    + +LEK +L +EL   L  R
Sbjct: 1679 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731

Query: 1472 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1531
              +           +++  L+A +  L+    E Q  +E +     K  Q+   L NE+ 
Sbjct: 1732 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 1532 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1591
            T       +      L    +E+  K    + E A   K     K  I+ L+ K  QL+ 
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1835

Query: 1592 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1646
            +  + +++     + L++ +++L E+L Q E E   +   + + EK N     LK +LE 
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895

Query: 1647 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDELEK 1685
             + +S  + ++   L+ EL E       + +E + LK +L +
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937



 Score =  104 bits (260), Expect = 8e-22
 Identities = 176/852 (20%), Positives = 359/852 (42%), Gaps = 136/852 (15%)

Query: 1236 KMLERIPEASPKYKLL---YEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQD 1292
            K  ER  +A  + K L   +  ++ E + LQE+L+     Y EA E    L A+   L++
Sbjct: 870  KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929

Query: 1293 ELKKME------------------EVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEK 1334
             L +ME                  ++ +  L LE+  +E +   ++L +  +  + KI+K
Sbjct: 930  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989

Query: 1335 LQESVVQRCDCCLWEASLENLEIEPDGNILQ-----LNQTLEECVPRVRSVHHVIEECKQ 1389
            L++ ++   D        +N ++  +  +L+     L   L E   + +++       K 
Sbjct: 990  LEDEILVMDD--------QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL------TKL 1035

Query: 1390 ENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQA 1449
            +N++    ++L  ++K  E        ++ QE  +++ +  LE + +   F ++    QA
Sbjct: 1036 KNKHESMISELEVRLKKEE--------KSRQELEKLKRK--LEGDAS--DFHEQIADLQA 1083

Query: 1450 TIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKV 1509
             IAEL+++      L +K +E    L +  D ++  +K   LK +  +L+   S++Q+ +
Sbjct: 1084 QIAELKMQ------LAKKEEELQAALARLDDEIA--QKNNALKKI-RELEGHISDLQEDL 1134

Query: 1510 ELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1569
            +  R    K +++   L  E+  L  E               E+    T T ++  A  +
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTE--------------LEDTLDSTATQQELRAKRE 1180

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK-----E 1624
            + V  LKK + E   + +  + +  E+ QK++Q  E+L E  ++        +K     E
Sbjct: 1181 QEVTVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237

Query: 1625 PGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELE 1684
              N+ L    +     K+E+E  K +    V  L+++ S+ +     +  + H L++E+E
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297

Query: 1685 KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMK 1744
             +  +     L++ + K         KL K+  +LS +L    + L + +  +  ++T  
Sbjct: 1298 SVTGM-----LNEAEGKAI-------KLAKDVASLSSQLQDTQELLQEETRQKLNVST-- 1343

Query: 1745 QEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVM 1804
             + +  E +  SL+ QL    E  QNLE  +  +N+Q+S  K  L+      EAL++   
Sbjct: 1344 -KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 1805 SLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQ 1864
               K+++N   +               ++K  ++DKL+   N     L QE + L   + 
Sbjct: 1403 RFQKEIENLTQQ--------------YEEKAAAYDKLEKTKNR----LQQELDDLVVDLD 1444

Query: 1865 NTKAELTHSREKVRQL------ESNLLPKH-QKHLNPSGTMNPTEQEKLSLKRECDQF-- 1915
            N +  +++  +K R+       E N+  K+  +           E + LSL R  ++   
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504

Query: 1916 QKEQSPANRKV--SQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1973
             KE+     K+  ++M  L    + +      L+K +  L+ Q+ EM+            
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1560

Query: 1974 HAWDLQLLQQQACPMVPREQFL--QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
               +LQ  +     +    Q L  Q +R L   +  N+  + +L+ +  E  T      +
Sbjct: 1561 ---ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617

Query: 2032 QRAVHADSYRRI 2043
            QRA+ A + +++
Sbjct: 1618 QRALAAAAKKKL 1629



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 57/277 (20%), Positives = 111/277 (40%), Gaps = 39/277 (14%)

Query: 323  QEILKALDFSLDGNINLTELTLALENELLVTKNSIH--QAALASFKAEIRHLLERVDQVV 380
            +E+ + L  SL G   L +    LE  +   +  +   Q  + +    +R   ++ +Q+ 
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 381  REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE-------EYKERIAAL 433
             E    RS   K E  +             +ER+N+    KL E       ++K  IAAL
Sbjct: 1778 NELATERSTAQKNESARQ-----------QLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 434  KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 493
            + ++ +  EQ+ Q+A +     +Q   K+  +++     + L +++  ++  +  E AEK
Sbjct: 1827 EAKIAQLEEQVEQEARE-----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881

Query: 494  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 553
                     +L+R LE        + +  S        +L +  +E       +  +V+ 
Sbjct: 1882 ---GNARVKQLKRQLE--------EAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
            L+S+L   R       +P + S    V  N+ G E E
Sbjct: 1931 LKSKL---RRGNETSFVPSRRSGGRRVIENADGSEEE 1964


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  153 bits (387), Expect = 1e-36
 Identities = 224/1134 (19%), Positives = 499/1134 (44%), Gaps = 120/1134 (10%)

Query: 754  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
            KV+ L Q   Q  + Q     ++  L+K + R++  E   +EL++   ++  E N    Q
Sbjct: 847  KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 814  IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 871
            ++A+ +  ++ +++  R  +  Q LE     E++   E++ +   Q + E+ ++ Q+  +
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961

Query: 872  AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 924
             +E L+E       L+ EK T+    ++ E       +  N +  ER+ L + + DL  N
Sbjct: 962  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021

Query: 925  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 984
            ++E ++   +  + +LK+ H+  + E E  L      E+ + Q LE+L+ + + +  +  
Sbjct: 1022 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 985  SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1043
             ++  ++  I +   + A +E  E+   ++RL  +I +   A   +  L+     I + +
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1131

Query: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
             + D   +   + E+   + G+ L +L+   E  +          ++ + R ++ +   V
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1185

Query: 1104 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1156
            +   LDE          E  +   Q  +  T+Q+E   R     D     LE +     G
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245

Query: 1157 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1213
                    +QEV  K ++ EA V+   S+  + E  R    EL +++ +LQ ++  +   
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1302

Query: 1214 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1273
             + A  K   L  DV+ L  +L+  + + +   + KL   +VS +   L+EE   ++ + 
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1359

Query: 1274 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1326
            DE +E  + L   +     +L D  KK+++   T  +LE+     + E E L        
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419

Query: 1327 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1384
                K+EK +  + Q  D  +    L+N + +   N+ +  +  ++ +   +++   +  
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 1385 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1443
            E  + E +  E  T+ L   +A E A     ++  +E  R  N+++  E   L+  +D  
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1530

Query: 1444 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1484
                       +A   ++E  KT+L+EL      T   K R+ + ++      ++D+ + 
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590

Query: 1485 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1538
             E+ EE    L+  +H+ +    + +++  L     +KL+ +  +  L+ +      E++
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 1539 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1586
            I  L+            L     S++E++   +  +++  +++  +  L++ ++  +   
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710

Query: 1587 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1643
            +Q DLE  EL+++   +   +  LQ+  +RL   + Q E+E     LEE +     + + 
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1765

Query: 1644 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1697
            + +   Q+  L + L  E S  +      QQ   +N  L+ +L +M+   +      ++ 
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1757
             + KI+ +    E+  +EK+A ++ L    DK  K  LL+  +   ++  + ++ Q+   
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1882

Query: 1758 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
             +++   + +++  E+  Q +N    +++ +L    +  EA+ +EV +L  +L+
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score =  147 bits (371), Expect = 1e-34
 Identities = 251/1125 (22%), Positives = 481/1125 (42%), Gaps = 189/1125 (16%)

Query: 345  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 404
            A E+EL  TK    +A     + E++ L ++  Q+  EK  L+  L    +L +  A E+
Sbjct: 863  AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 916

Query: 405  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 453
                AA ++  E  L +++   EE ++R   L+ E +K  +Q+L        ++A +Q+L
Sbjct: 917  RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976

Query: 454  ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 502
            +LE+   +AK ++  + D + +   +N++L  E +LLE          AE+  + +NLT 
Sbjct: 977  QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1033

Query: 503  KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 558
            KL+   E++++E   +    + S  E    + +L    +++  Q   LQ Q+ EL+ +L 
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 559  -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 598
             +E   Q  + RL      KN+  +++    G I + +  L SE                
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 599  ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 652
                    L  ++++    ++++ +  +++  L+  L+++ R +E Q+ E      +A E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213

Query: 653  NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
             + ++ E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1269

Query: 710  E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 747
            E           +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q 
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329

Query: 748  SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
                E + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 807  CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 851
                 S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 852  RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 889
            R+     EK Q +F++             DE  +  AEA+E  KET    L R    +L 
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1504

Query: 890  LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 946
              +E E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1560

Query: 947  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1006
            EL+  E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620

Query: 1007 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1066
              +    +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D 
Sbjct: 1621 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1664

Query: 1067 LLSLQRAHEQ------AVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
               L+ A           KEN K A     L+  L +L+  L  +    + A       A
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKA---KSLEADLMQLQEDLAAAERARKQADLEKEELA 1721

Query: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGF 1180
            E+    L      Q E       ++ LE++   + G+    S + ++   +  + S E  
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 1181 SELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER 1240
            +E   +++  +   +L+ Q  +L+ +L       +     K      ++ L+ K+  LE 
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLH------EMEGAVKSKFKSTIAALEAKIAQLEE 1835

Query: 1241 IPEASPKYK------LLYEDVSRENDCLQ-EELRMMETRYDEALENNKELTAEVFRLQDE 1293
              E   + K      L  +D   +   LQ E+ R M  +Y E  E      A V +L+ +
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG---NARVKQLKRQ 1892

Query: 1294 LKKMEEVTETF----LSLEKSYDEVKIENE----ELNVLVLRLQG 1330
            L++ EE ++        L++  DE    NE    E+N L  +L+G
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937



 Score =  145 bits (367), Expect = 3e-34
 Identities = 246/1108 (22%), Positives = 460/1108 (41%), Gaps = 172/1108 (15%)

Query: 315  QEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLE 374
            +++  EN  + L+     L    NL +  L  E EL      + +  LA+ K E+  +L 
Sbjct: 874  RQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM-RVRLAAKKQELEEILH 932

Query: 375  RVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIER----RNEYNLRKLDEEYK--- 427
             ++  + E+E     L +AE+ K  MA ++ D    +E     R +  L K+  E K   
Sbjct: 933  EMEARLEEEEDRGQQL-QAERKK--MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989

Query: 428  --ERIAAL---KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 482
              + I  +    N+L KER+ + ++       L +E EKAK          ++     S 
Sbjct: 990  LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI----SE 1045

Query: 483  LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 542
            LE  L +  +   E E L  KL+ +  +   E+  DL    AE  +Q   L +   E + 
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASD-FHEQIADLQAQIAELKMQ---LAKKEEELQA 1101

Query: 543  QCRVLQDQVDELQSELEEYRA-QGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
                L D++ +  + L++ R  +G +    L+     E  A +   + +  LG EE   L
Sbjct: 1102 ALARLDDEIAQKNNALKKIRELEGHIS--DLQEDLDSERAARNKAEKQKRDLG-EELEAL 1158

Query: 602  NMSIEAEL----VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 657
               +E  L      ++++ +  +++  L+  L+++ R +E Q+ E      +A E + ++
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218

Query: 658  HENETHT---LEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE---- 710
             E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++E    
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQELQSK 1274

Query: 711  ------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQSSAWTE 752
                   +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q     E
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334

Query: 753  EKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 811
             + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +     
Sbjct: 1335 TRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391

Query: 812  SQIEA------QFQSDCQKVTERCESA------LQSLEGRYRQELKDLQ---EQQRE--- 853
            S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + QR+   
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 854  --EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLVLTQER 894
              EK Q +F++             DE  +  AEA+E  KET    L R    +L   +E 
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALEAKEEL 1509

Query: 895  EMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKRELRER 951
            E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     EL+  
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED----ELQAT 1565

Query: 952  EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTE 1011
            E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA  +  
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625

Query: 1012 ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQ 1071
              +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D    L+
Sbjct: 1626 KKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDFQRELE 1669

Query: 1072 RAHEQ------AVKENVKMA----TEISRLQQRLQKLEPG-----LVMSSCLDEPATEFF 1116
             A           KEN K A     ++ +LQ+ L   E       L      +E A+   
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729

Query: 1117 GNTAEQTEPFLQQNRTKQVE-----------GVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
            G  A Q E    + R  Q+E            ++ R   +  + +++ +  +T  S+ Q+
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789

Query: 1166 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL 1225
             E   ++ E   +      +  E   +S + K+ I+ L+ ++  L    ++ + +KQ   
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848

Query: 1226 FDVSVLKKKLK-----------MLERIPEASPK-------YKLLYEDVSRENDCLQEELR 1267
              +    KKLK           M E+  E + K        K   E+   E+  +    R
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908

Query: 1268 MMETRYDEALENNKELTAEVFRLQDELK 1295
             ++   DEA E+N+ +  EV  L+ +L+
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSKLR 1936



 Score =  145 bits (366), Expect = 4e-34
 Identities = 245/1200 (20%), Positives = 509/1200 (42%), Gaps = 169/1200 (14%)

Query: 427  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
            +E + A ++EL+K +E+  Q+A  +  ELEQ+  +   E+N ++++L    +  +  E  
Sbjct: 858  EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916

Query: 487  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 546
             +  A K  E E + ++++  LE                   +E+R  Q++ E ++  + 
Sbjct: 917  RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 958

Query: 547  LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 606
            + D    L+ +LEE  A  + L+L    +     EA    +E E  +  ++ N L+    
Sbjct: 959  MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1007

Query: 607  AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 653
                  ++ E+   D+     E E+K ++       +E  + E  V  KK +      E 
Sbjct: 1008 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 654  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 713
            +K++ E +     +QI+DL+ +IAEL+ Q A  +E    A  R ++E  Q        K 
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1114

Query: 714  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 773
            +  +K+R     EL+  ++  Q   + ER     +   E++ R L +ELE    E     
Sbjct: 1115 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1162

Query: 774  VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 833
              + TL+    ++EL  K ++E+   ++ ++ E     +Q++   Q   Q V E  E   
Sbjct: 1163 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219

Query: 834  QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
                    ++ K  +    + K   E E  +L  E     +  +E   ++K       Q 
Sbjct: 1220 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1268

Query: 894  REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 948
            +E+  K       +  LN  V + Q  ++ +  + N +E +   L+  +  L S    +L
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1324

Query: 949  REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1008
            ++ +E+L +    +   S +L +LE E +  + ++  ++ A +N+ +            +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1373

Query: 1009 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
            ST   +L    K++Q   S +  L+ G +   ++E+E     +L QQ     EE      
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1423

Query: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1128
             L++   +  +E   +  ++   +Q +  LE        L           A++ +    
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 1129 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1187
            + R K+ + ++    L + LE  E  +L  T        E  +   +   +   ELE S+
Sbjct: 1484 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541

Query: 1188 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1238
                T+  E+K Q+ +L+++L       L  + +  + K Q   DL       ++K + L
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601

Query: 1239 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1291
            +R      +Y+   ED  ++          L+ +L+ +E + D A++  +E   ++ +LQ
Sbjct: 1602 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658

Query: 1292 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1351
             ++K  +   E       S DE+    +E       L+  + +LQE +    +    +A 
Sbjct: 1659 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1714

Query: 1352 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1405
            LE  E+ E   + L     L++   R+ + +  + EE ++E   +E  +  + K      
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 1406 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1460
              ++E+A    T Q ++   ++   QN+ +  +   + G     F  ++TIA LE +  +
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1832

Query: 1461 LQE-LTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKL 1519
            L+E + ++ +E      KQ    S  +K+++LK ++  LQ+   + ++  E  + ++EK 
Sbjct: 1833 LEEQVEQEARE------KQAATKSLKQKDKKLKEIL--LQV--EDERKMAEQYKEQAEKG 1882

Query: 1520 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1579
                  L+ ++    EE          +N ++ ++ ++ +   + N A+ + V  LK ++
Sbjct: 1883 NARVKQLKRQLEEAEEESQ-------RINANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score =  139 bits (349), Expect = 4e-32
 Identities = 242/1180 (20%), Positives = 492/1180 (41%), Gaps = 146/1180 (12%)

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 613
            LQ   +E   Q +   L       ++ E     +E +H   +EE N L   ++AE  +  
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 614  MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 673
              E+    +   + ELE+ +   E +L+E        +E+  Q+ + E   + +Q+ DL+
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 963

Query: 674  NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 733
             ++ E +     L+     A  + ++ + ++ V ++++   L ++ +L     L+ R++ 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1017

Query: 734  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 793
               +   E          EEK + LT +L+  H+  ++ L  +  L+KEE  ++ LEK +
Sbjct: 1018 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1064

Query: 794  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 853
            R+L+        +     +QI A+ +    K  E  ++AL  L+    Q+   L++ +  
Sbjct: 1065 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123

Query: 854  EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 911
            E    + ++D  ++  A  +    E  KR+      L +E E L+   ++ L+S   +  
Sbjct: 1124 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1174

Query: 912  -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 970
             R +  Q++  L+   + +      Q+ E++  H + + E  E L Q   ++    +  +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234

Query: 971  RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1017
             LE E+              QE +    KL A     ++ C   +R RAE++ ++ +LQ+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294

Query: 1018 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1062
            +               IK  +   S  S LQ   +++ EE  +     + L+Q E+  E 
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1352

Query: 1063 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
            N    L  Q   E   K+N++  ++T   +L    +KL+        L+E    F     
Sbjct: 1353 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1178
              T+ + ++         T+  +  +L DD V DL +     S++++++ K ++  A  +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468

Query: 1179 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1238
              S     E  R E+     +  + + + + L    + A E K++L     +LK +++ L
Sbjct: 1469 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 1239 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1298
                  S K     +DV +    L++  R +ET+ +E     +EL  E+   +D   ++E
Sbjct: 1524 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 1299 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1352
               +      E+       +NEE    + R   + E +L++   QR          E  L
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 1353 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1412
            ++LE++ D  I    +  EE + ++R +   +++ ++E          LE  +A     +
Sbjct: 1634 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1678

Query: 1413 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1471
              T + ++++ +            L+  Q+     +    + +LEK +L +EL   L  R
Sbjct: 1679 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731

Query: 1472 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1531
              +           +++  L+A +  L+    E Q  +E +     K  Q+   L NE+ 
Sbjct: 1732 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 1532 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1591
            T       +      L    +E+  K    + E A   K     K  I+ L+ K  QL+ 
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1835

Query: 1592 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1646
            +  + +++     + L++ +++L E+L Q E E   +   + + EK N     LK +LE 
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895

Query: 1647 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDEL 1683
             + +S  + ++   L+ EL E       + +E + LK +L
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score =  104 bits (260), Expect = 8e-22
 Identities = 176/852 (20%), Positives = 359/852 (42%), Gaps = 136/852 (15%)

Query: 1236 KMLERIPEASPKYKLL---YEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQD 1292
            K  ER  +A  + K L   +  ++ E + LQE+L+     Y EA E    L A+   L++
Sbjct: 870  KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929

Query: 1293 ELKKME------------------EVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEK 1334
             L +ME                  ++ +  L LE+  +E +   ++L +  +  + KI+K
Sbjct: 930  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989

Query: 1335 LQESVVQRCDCCLWEASLENLEIEPDGNILQ-----LNQTLEECVPRVRSVHHVIEECKQ 1389
            L++ ++   D        +N ++  +  +L+     L   L E   + +++       K 
Sbjct: 990  LEDEILVMDD--------QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL------TKL 1035

Query: 1390 ENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQA 1449
            +N++    ++L  ++K  E        ++ QE  +++ +  LE + +   F ++    QA
Sbjct: 1036 KNKHESMISELEVRLKKEE--------KSRQELEKLKRK--LEGDAS--DFHEQIADLQA 1083

Query: 1450 TIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKV 1509
             IAEL+++      L +K +E    L +  D ++  +K   LK +  +L+   S++Q+ +
Sbjct: 1084 QIAELKMQ------LAKKEEELQAALARLDDEIA--QKNNALKKI-RELEGHISDLQEDL 1134

Query: 1510 ELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1569
            +  R    K +++   L  E+  L  E               E+    T T ++  A  +
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTE--------------LEDTLDSTATQQELRAKRE 1180

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK-----E 1624
            + V  LKK + E   + +  + +  E+ QK++Q  E+L E  ++        +K     E
Sbjct: 1181 QEVTVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237

Query: 1625 PGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELE 1684
              N+ L    +     K+E+E  K +    V  L+++ S+ +     +  + H L++E+E
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297

Query: 1685 KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMK 1744
             +  +     L++ + K         KL K+  +LS +L    + L + +  +  ++T  
Sbjct: 1298 SVTGM-----LNEAEGKAI-------KLAKDVASLSSQLQDTQELLQEETRQKLNVST-- 1343

Query: 1745 QEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVM 1804
             + +  E +  SL+ QL    E  QNLE  +  +N+Q+S  K  L+      EAL++   
Sbjct: 1344 -KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 1805 SLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQ 1864
               K+++N   +               ++K  ++DKL+   N     L QE + L   + 
Sbjct: 1403 RFQKEIENLTQQ--------------YEEKAAAYDKLEKTKNR----LQQELDDLVVDLD 1444

Query: 1865 NTKAELTHSREKVRQL------ESNLLPKH-QKHLNPSGTMNPTEQEKLSLKRECDQF-- 1915
            N +  +++  +K R+       E N+  K+  +           E + LSL R  ++   
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504

Query: 1916 QKEQSPANRKV--SQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1973
             KE+     K+  ++M  L    + +      L+K +  L+ Q+ EM+            
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1560

Query: 1974 HAWDLQLLQQQACPMVPREQFL--QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
               +LQ  +     +    Q L  Q +R L   +  N+  + +L+ +  E  T      +
Sbjct: 1561 ---ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617

Query: 2032 QRAVHADSYRRI 2043
            QRA+ A + +++
Sbjct: 1618 QRALAAAAKKKL 1629


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  153 bits (387), Expect = 1e-36
 Identities = 224/1134 (19%), Positives = 499/1134 (44%), Gaps = 120/1134 (10%)

Query: 754  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
            KV+ L Q   Q  + Q     ++  L+K + R++  E   +EL++   ++  E N    Q
Sbjct: 840  KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 814  IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 871
            ++A+ +  ++ +++  R  +  Q LE     E++   E++ +   Q + E+ ++ Q+  +
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954

Query: 872  AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 924
             +E L+E       L+ EK T+    ++ E       +  N +  ER+ L + + DL  N
Sbjct: 955  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014

Query: 925  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 984
            ++E ++   +  + +LK+ H+  + E E  L      E+ + Q LE+L+ + + +  +  
Sbjct: 1015 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 985  SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1043
             ++  ++  I +   + A +E  E+   ++RL  +I +   A   +  L+     I + +
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1124

Query: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
             + D   +   + E+   + G+ L +L+   E  +          ++ + R ++ +   V
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1178

Query: 1104 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1156
            +   LDE          E  +   Q  +  T+Q+E   R     D     LE +     G
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238

Query: 1157 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1213
                    +QEV  K ++ EA V+   S+  + E  R    EL +++ +LQ ++  +   
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1295

Query: 1214 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1273
             + A  K   L  DV+ L  +L+  + + +   + KL   +VS +   L+EE   ++ + 
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1352

Query: 1274 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1326
            DE +E  + L   +     +L D  KK+++   T  +LE+     + E E L        
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412

Query: 1327 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1384
                K+EK +  + Q  D  +    L+N + +   N+ +  +  ++ +   +++   +  
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 1385 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1443
            E  + E +  E  T+ L   +A E A     ++  +E  R  N+++  E   L+  +D  
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1523

Query: 1444 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1484
                       +A   ++E  KT+L+EL      T   K R+ + ++      ++D+ + 
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583

Query: 1485 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1538
             E+ EE    L+  +H+ +    + +++  L     +KL+ +  +  L+ +      E++
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643

Query: 1539 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1586
            I  L+            L     S++E++   +  +++  +++  +  L++ ++  +   
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703

Query: 1587 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1643
            +Q DLE  EL+++   +   +  LQ+  +RL   + Q E+E     LEE +     + + 
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1758

Query: 1644 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1697
            + +   Q+  L + L  E S  +      QQ   +N  L+ +L +M+   +      ++ 
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1757
             + KI+ +    E+  +EK+A ++ L    DK  K  LL+  +   ++  + ++ Q+   
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1875

Query: 1758 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
             +++   + +++  E+  Q +N    +++ +L    +  EA+ +EV +L  +L+
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929



 Score =  147 bits (371), Expect = 1e-34
 Identities = 251/1125 (22%), Positives = 481/1125 (42%), Gaps = 189/1125 (16%)

Query: 345  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 404
            A E+EL  TK    +A     + E++ L ++  Q+  EK  L+  L    +L +  A E+
Sbjct: 856  AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 909

Query: 405  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 453
                AA ++  E  L +++   EE ++R   L+ E +K  +Q+L        ++A +Q+L
Sbjct: 910  RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969

Query: 454  ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 502
            +LE+   +AK ++  + D + +   +N++L  E +LLE          AE+  + +NLT 
Sbjct: 970  QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1026

Query: 503  KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 558
            KL+   E++++E   +    + S  E    + +L    +++  Q   LQ Q+ EL+ +L 
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 559  -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 598
             +E   Q  + RL      KN+  +++    G I + +  L SE                
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 599  ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 652
                    L  ++++    ++++ +  +++  L+  L+++ R +E Q+ E      +A E
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206

Query: 653  NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
             + ++ E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1262

Query: 710  E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 747
            E           +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q 
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322

Query: 748  SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
                E + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 807  CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 851
                 S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 852  RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 889
            R+     EK Q +F++             DE  +  AEA+E  KET    L R    +L 
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1497

Query: 890  LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 946
              +E E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1553

Query: 947  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1006
            EL+  E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613

Query: 1007 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1066
              +    +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D 
Sbjct: 1614 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1657

Query: 1067 LLSLQRAHEQ------AVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
               L+ A           KEN K A     L+  L +L+  L  +    + A       A
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKA---KSLEADLMQLQEDLAAAERARKQADLEKEELA 1714

Query: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGF 1180
            E+    L      Q E       ++ LE++   + G+    S + ++   +  + S E  
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774

Query: 1181 SELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER 1240
            +E   +++  +   +L+ Q  +L+ +L       +     K      ++ L+ K+  LE 
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLH------EMEGAVKSKFKSTIAALEAKIAQLEE 1828

Query: 1241 IPEASPKYK------LLYEDVSRENDCLQ-EELRMMETRYDEALENNKELTAEVFRLQDE 1293
              E   + K      L  +D   +   LQ E+ R M  +Y E  E      A V +L+ +
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG---NARVKQLKRQ 1885

Query: 1294 LKKMEEVTETF----LSLEKSYDEVKIENE----ELNVLVLRLQG 1330
            L++ EE ++        L++  DE    NE    E+N L  +L+G
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1930



 Score =  145 bits (367), Expect = 3e-34
 Identities = 246/1108 (22%), Positives = 460/1108 (41%), Gaps = 172/1108 (15%)

Query: 315  QEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLE 374
            +++  EN  + L+     L    NL +  L  E EL      + +  LA+ K E+  +L 
Sbjct: 867  RQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM-RVRLAAKKQELEEILH 925

Query: 375  RVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIER----RNEYNLRKLDEEYK--- 427
             ++  + E+E     L +AE+ K  MA ++ D    +E     R +  L K+  E K   
Sbjct: 926  EMEARLEEEEDRGQQL-QAERKK--MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982

Query: 428  --ERIAAL---KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 482
              + I  +    N+L KER+ + ++       L +E EKAK          ++     S 
Sbjct: 983  LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI----SE 1038

Query: 483  LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 542
            LE  L +  +   E E L  KL+ +  +   E+  DL    AE  +Q   L +   E + 
Sbjct: 1039 LEVRLKKEEKSRQELEKLKRKLEGDASD-FHEQIADLQAQIAELKMQ---LAKKEEELQA 1094

Query: 543  QCRVLQDQVDELQSELEEYRA-QGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
                L D++ +  + L++ R  +G +    L+     E  A +   + +  LG EE   L
Sbjct: 1095 ALARLDDEIAQKNNALKKIRELEGHIS--DLQEDLDSERAARNKAEKQKRDLG-EELEAL 1151

Query: 602  NMSIEAEL----VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 657
               +E  L      ++++ +  +++  L+  L+++ R +E Q+ E      +A E + ++
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211

Query: 658  HENETHT---LEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE---- 710
             E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++E    
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQELQSK 1267

Query: 711  ------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQSSAWTE 752
                   +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q     E
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327

Query: 753  EKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 811
             + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +     
Sbjct: 1328 TRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384

Query: 812  SQIEA------QFQSDCQKVTERCESA------LQSLEGRYRQELKDLQ---EQQRE--- 853
            S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + QR+   
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 854  --EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLVLTQER 894
              EK Q +F++             DE  +  AEA+E  KET    L R    +L   +E 
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALEAKEEL 1502

Query: 895  EMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKRELRER 951
            E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     EL+  
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED----ELQAT 1558

Query: 952  EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTE 1011
            E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA  +  
Sbjct: 1559 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618

Query: 1012 ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQ 1071
              +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D    L+
Sbjct: 1619 KKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDFQRELE 1662

Query: 1072 RAHEQ------AVKENVKMA----TEISRLQQRLQKLEPG-----LVMSSCLDEPATEFF 1116
             A           KEN K A     ++ +LQ+ L   E       L      +E A+   
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722

Query: 1117 GNTAEQTEPFLQQNRTKQVE-----------GVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
            G  A Q E    + R  Q+E            ++ R   +  + +++ +  +T  S+ Q+
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782

Query: 1166 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL 1225
             E   ++ E   +      +  E   +S + K+ I+ L+ ++  L    ++ + +KQ   
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841

Query: 1226 FDVSVLKKKLK-----------MLERIPEASPK-------YKLLYEDVSRENDCLQEELR 1267
              +    KKLK           M E+  E + K        K   E+   E+  +    R
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901

Query: 1268 MMETRYDEALENNKELTAEVFRLQDELK 1295
             ++   DEA E+N+ +  EV  L+ +L+
Sbjct: 1902 KLQRELDEATESNEAMGREVNALKSKLR 1929



 Score =  145 bits (366), Expect = 4e-34
 Identities = 245/1200 (20%), Positives = 509/1200 (42%), Gaps = 169/1200 (14%)

Query: 427  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
            +E + A ++EL+K +E+  Q+A  +  ELEQ+  +   E+N ++++L    +  +  E  
Sbjct: 851  EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909

Query: 487  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 546
             +  A K  E E + ++++  LE                   +E+R  Q++ E ++  + 
Sbjct: 910  RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 951

Query: 547  LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 606
            + D    L+ +LEE  A  + L+L    +     EA    +E E  +  ++ N L+    
Sbjct: 952  MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1000

Query: 607  AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 653
                  ++ E+   D+     E E+K ++       +E  + E  V  KK +      E 
Sbjct: 1001 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055

Query: 654  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 713
            +K++ E +     +QI+DL+ +IAEL+ Q A  +E    A  R ++E  Q        K 
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1107

Query: 714  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 773
            +  +K+R     EL+  ++  Q   + ER     +   E++ R L +ELE    E     
Sbjct: 1108 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1155

Query: 774  VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 833
              + TL+    ++EL  K ++E+   ++ ++ E     +Q++   Q   Q V E  E   
Sbjct: 1156 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1212

Query: 834  QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
                    ++ K  +    + K   E E  +L  E     +  +E   ++K       Q 
Sbjct: 1213 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1261

Query: 894  REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 948
            +E+  K       +  LN  V + Q  ++ +  + N +E +   L+  +  L S    +L
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1317

Query: 949  REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1008
            ++ +E+L +    +   S +L +LE E +  + ++  ++ A +N+ +            +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1366

Query: 1009 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
            ST   +L    K++Q   S +  L+ G +   ++E+E     +L QQ     EE      
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1416

Query: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1128
             L++   +  +E   +  ++   +Q +  LE        L           A++ +    
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476

Query: 1129 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1187
            + R K+ + ++    L + LE  E  +L  T        E  +   +   +   ELE S+
Sbjct: 1477 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534

Query: 1188 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1238
                T+  E+K Q+ +L+++L       L  + +  + K Q   DL       ++K + L
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594

Query: 1239 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1291
            +R      +Y+   ED  ++          L+ +L+ +E + D A++  +E   ++ +LQ
Sbjct: 1595 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651

Query: 1292 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1351
             ++K  +   E       S DE+    +E       L+  + +LQE +    +    +A 
Sbjct: 1652 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1707

Query: 1352 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1405
            LE  E+ E   + L     L++   R+ + +  + EE ++E   +E  +  + K      
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767

Query: 1406 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1460
              ++E+A    T Q ++   ++   QN+ +  +   + G     F  ++TIA LE +  +
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1825

Query: 1461 LQE-LTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKL 1519
            L+E + ++ +E      KQ    S  +K+++LK ++  LQ+   + ++  E  + ++EK 
Sbjct: 1826 LEEQVEQEARE------KQAATKSLKQKDKKLKEIL--LQV--EDERKMAEQYKEQAEKG 1875

Query: 1520 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1579
                  L+ ++    EE          +N ++ ++ ++ +   + N A+ + V  LK ++
Sbjct: 1876 NARVKQLKRQLEEAEEESQ-------RINANRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score =  139 bits (349), Expect = 4e-32
 Identities = 242/1180 (20%), Positives = 492/1180 (41%), Gaps = 146/1180 (12%)

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 613
            LQ   +E   Q +   L       ++ E     +E +H   +EE N L   ++AE  +  
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 614  MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 673
              E+    +   + ELE+ +   E +L+E        +E+  Q+ + E   + +Q+ DL+
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 956

Query: 674  NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 733
             ++ E +     L+     A  + ++ + ++ V ++++   L ++ +L     L+ R++ 
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1010

Query: 734  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 793
               +   E          EEK + LT +L+  H+  ++ L  +  L+KEE  ++ LEK +
Sbjct: 1011 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1057

Query: 794  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 853
            R+L+        +     +QI A+ +    K  E  ++AL  L+    Q+   L++ +  
Sbjct: 1058 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1116

Query: 854  EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 911
            E    + ++D  ++  A  +    E  KR+      L +E E L+   ++ L+S   +  
Sbjct: 1117 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1167

Query: 912  -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 970
             R +  Q++  L+   + +      Q+ E++  H + + E  E L Q   ++    +  +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227

Query: 971  RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1017
             LE E+              QE +    KL A     ++ C   +R RAE++ ++ +LQ+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287

Query: 1018 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1062
            +               IK  +   S  S LQ   +++ EE  +     + L+Q E+  E 
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1345

Query: 1063 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
            N    L  Q   E   K+N++  ++T   +L    +KL+        L+E    F     
Sbjct: 1346 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402

Query: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1178
              T+ + ++         T+  +  +L DD V DL +     S++++++ K ++  A  +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461

Query: 1179 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1238
              S     E  R E+     +  + + + + L    + A E K++L     +LK +++ L
Sbjct: 1462 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 1239 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1298
                  S K     +DV +    L++  R +ET+ +E     +EL  E+   +D   ++E
Sbjct: 1517 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 1299 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1352
               +      E+       +NEE    + R   + E +L++   QR          E  L
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 1353 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1412
            ++LE++ D  I    +  EE + ++R +   +++ ++E          LE  +A     +
Sbjct: 1627 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1671

Query: 1413 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1471
              T + ++++ +            L+  Q+     +    + +LEK +L +EL   L  R
Sbjct: 1672 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724

Query: 1472 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1531
              +           +++  L+A +  L+    E Q  +E +     K  Q+   L NE+ 
Sbjct: 1725 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774

Query: 1532 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1591
            T       +      L    +E+  K    + E A   K     K  I+ L+ K  QL+ 
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1828

Query: 1592 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1646
            +  + +++     + L++ +++L E+L Q E E   +   + + EK N     LK +LE 
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888

Query: 1647 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDEL 1683
             + +S  + ++   L+ EL E       + +E + LK +L
Sbjct: 1889 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score =  104 bits (260), Expect = 8e-22
 Identities = 176/852 (20%), Positives = 359/852 (42%), Gaps = 136/852 (15%)

Query: 1236 KMLERIPEASPKYKLL---YEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQD 1292
            K  ER  +A  + K L   +  ++ E + LQE+L+     Y EA E    L A+   L++
Sbjct: 863  KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922

Query: 1293 ELKKME------------------EVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEK 1334
             L +ME                  ++ +  L LE+  +E +   ++L +  +  + KI+K
Sbjct: 923  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982

Query: 1335 LQESVVQRCDCCLWEASLENLEIEPDGNILQ-----LNQTLEECVPRVRSVHHVIEECKQ 1389
            L++ ++   D        +N ++  +  +L+     L   L E   + +++       K 
Sbjct: 983  LEDEILVMDD--------QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL------TKL 1028

Query: 1390 ENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQA 1449
            +N++    ++L  ++K  E        ++ QE  +++ +  LE + +   F ++    QA
Sbjct: 1029 KNKHESMISELEVRLKKEE--------KSRQELEKLKRK--LEGDAS--DFHEQIADLQA 1076

Query: 1450 TIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKV 1509
             IAEL+++      L +K +E    L +  D ++  +K   LK +  +L+   S++Q+ +
Sbjct: 1077 QIAELKMQ------LAKKEEELQAALARLDDEIA--QKNNALKKI-RELEGHISDLQEDL 1127

Query: 1510 ELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1569
            +  R    K +++   L  E+  L  E               E+    T T ++  A  +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTE--------------LEDTLDSTATQQELRAKRE 1173

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK-----E 1624
            + V  LKK + E   + +  + +  E+ QK++Q  E+L E  ++        +K     E
Sbjct: 1174 QEVTVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230

Query: 1625 PGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELE 1684
              N+ L    +     K+E+E  K +    V  L+++ S+ +     +  + H L++E+E
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290

Query: 1685 KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMK 1744
             +  +     L++ + K         KL K+  +LS +L    + L + +  +  ++T  
Sbjct: 1291 SVTGM-----LNEAEGKAI-------KLAKDVASLSSQLQDTQELLQEETRQKLNVST-- 1336

Query: 1745 QEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVM 1804
             + +  E +  SL+ QL    E  QNLE  +  +N+Q+S  K  L+      EAL++   
Sbjct: 1337 -KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 1805 SLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQ 1864
               K+++N   +               ++K  ++DKL+   N     L QE + L   + 
Sbjct: 1396 RFQKEIENLTQQ--------------YEEKAAAYDKLEKTKNR----LQQELDDLVVDLD 1437

Query: 1865 NTKAELTHSREKVRQL------ESNLLPKH-QKHLNPSGTMNPTEQEKLSLKRECDQF-- 1915
            N +  +++  +K R+       E N+  K+  +           E + LSL R  ++   
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497

Query: 1916 QKEQSPANRKV--SQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1973
             KE+     K+  ++M  L    + +      L+K +  L+ Q+ EM+            
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1553

Query: 1974 HAWDLQLLQQQACPMVPREQFL--QLQRQLLQAERINQHLQEELENRTSETNTPQALLPE 2031
               +LQ  +     +    Q L  Q +R L   +  N+  + +L+ +  E  T      +
Sbjct: 1554 ---ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610

Query: 2032 QRAVHADSYRRI 2043
            QRA+ A + +++
Sbjct: 1611 QRALAAAAKKKL 1622


>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
          Length = 2479

 Score =  153 bits (386), Expect = 2e-36
 Identities = 410/2090 (19%), Positives = 807/2090 (38%), Gaps = 409/2090 (19%)

Query: 323  QEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVRE 382
            +E+ KA +        L    + LENEL + + S         + EI  L ++++Q  RE
Sbjct: 71   EEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRE 130

Query: 383  KEKLRSDLDKAEKLKSLMA---SEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRK 439
             E +  +L+K +K+   +A    E ++ ++ + R N+  L+K +E+  + I   + ++  
Sbjct: 131  LEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENK-RLKKKNEQLCQDIIDYQKQIDS 189

Query: 440  EREQILQQAG----------KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLE 489
            ++E +L + G          K+  EL Q +++ +T      +++ +  +E  +   E ++
Sbjct: 190  QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTE-ANEKIEVQNQEMRKNLEESVQ 248

Query: 490  NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQM---RNEYERQCRV 546
              EK+ +  N    +    +NV+ +    L   +  + LQ + LT +   +NE +    V
Sbjct: 249  EMEKMTDEYNRMKAIVHQTDNVIDQ----LKKENDHYQLQVQELTDLLKSKNEEDDPIMV 304

Query: 547  -LQDQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 598
             +  +V+E +        E+ EY+     LR  LKN+  +  ++N   ++        + 
Sbjct: 305  AVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQI 364

Query: 599  NPLNMSIEA--------ELVIEQMK-------------EQHHRDICCLRLELEDKVRHYE 637
              L   +E           +IE +K             +Q H  I      L++K +  E
Sbjct: 365  KMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAE 424

Query: 638  KQ-------------------------------LDETVVSCKKAQENMKQRHEN------ 660
            +                                L++ VV  K  +  +K R         
Sbjct: 425  RTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTK 484

Query: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEAT-CRHEEEKKQLQVKLEEEKTHLQEKL 719
            E + LE +ISD  +E   L+ +  +  +   + T  R+ +  KQ Q + E +    + + 
Sbjct: 485  EINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIES 544

Query: 720  RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ---FHQEQLTSLVEK 776
              +  ++LK ++ Q     ER +    S   TE+    LT+ + Q     + +L  L  K
Sbjct: 545  LEEERLDLKKKIRQMAQ--ERGKRSATSGLTTEDL--NLTENISQGDRISERKLDLLSLK 600

Query: 777  HTLE----KEELRKELLEKHQRELQEGREKMETECNR------RTSQIEAQFQSDCQKVT 826
            +  E     E L +EL+EK +R+L+  R  +    N+         Q+E   +   Q + 
Sbjct: 601  NMSEAQSKNEFLSRELIEK-ERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIK 659

Query: 827  ER-----------------CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869
            E                   E  + ++E +  + + D     + +  Q     +EL QE 
Sbjct: 660  EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL 719

Query: 870  AEA--------QELLKETLK---REKTTSLVLTQEREML--------------------- 897
             E+        Q+L K  LK    EK TSL+   E   +                     
Sbjct: 720  RESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINS 779

Query: 898  EKTYKEHLNSMVVERQQLLQDLEDLRN-------VSETQQSLLSDQILELKSSHK----- 945
            +  Y  HL   +  +++ L++LED          V   QQSLL  + L  K + K     
Sbjct: 780  QNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKT 839

Query: 946  --RELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATC-ETAD 1002
               E R+ E+ + Q     +  +  L  L+M+ D+     M K+LA EN  K T  +  +
Sbjct: 840  IKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDE-----MKKILA-ENSRKITVLQVNE 893

Query: 1003 RERAEMSTEISRLQSKIKEM--QQATSPLSMLQSGCQVIG----------------EEEV 1044
            +      T +  L+ ++++   +Q    LSM    C+ IG                ++ V
Sbjct: 894  KSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953

Query: 1045 EGDGALS------------------LLQQGEQLLEE---------------------NGD 1065
            +   +LS                  +LQ+   L++                      N +
Sbjct: 954  DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKE 1013

Query: 1066 VLLSLQRAH--EQAVKENVKMATEISRLQQR----------LQKLEPGLVMSSCLDEPAT 1113
            + ++ ++ H  EQA ++  K+  E S  + +          + K    L M    +    
Sbjct: 1014 LEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRA 1073

Query: 1114 EFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE----------DDEVRDLGSTGTSSV 1163
            E      E     L+Q   +  E  T+   L+ +            DE+ D  S   S  
Sbjct: 1074 EHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDA 1133

Query: 1164 QRQ---EVKIEESEASVEGFSELENSEETRTESWELKNQISQLQ----EQLMMLCADCDR 1216
             RQ   E++  E E  VE  S+L    +      E+ N   Q +    E L M   D   
Sbjct: 1134 DRQRILELEKNEMELKVE-VSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192

Query: 1217 ASEKKQDLL----FDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETR 1272
             S++K  +      +VS+   +   L ++   + K + +     R    L E+ + +   
Sbjct: 1193 QSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYA 1252

Query: 1273 YDEALENNKELTAEVFRLQDE------LKKMEEVTETFLSLEKSYDEVKI---------E 1317
              E     K L   +  L+ +      L + E+ ++T + L+   D++KI         E
Sbjct: 1253 RLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN--DKLKIMQEMKNSQQE 1310

Query: 1318 NEELNVLVLRLQGKIEKLQESVVQRCDC------CLWEASLENLEIEPDGNILQLNQTLE 1371
            +  +    L ++ K++ L+E +    D         W   +E L ++     L+LN+ L 
Sbjct: 1311 HRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQE----LKLNRELV 1366

Query: 1372 ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE---IAWLHGTIQTHQERPRVQNQ 1428
            +    ++ ++++I E ++    LE   +++++ K HE   +AW    +   +     Q  
Sbjct: 1367 KDKEEIKYLNNIISEYERTISSLE--EEIVQQNKFHEERQMAWDQREVDLER-----QLD 1419

Query: 1429 VILEENTTLLGFQDKHFQHQATIAELELE-KTKLQELTRKLKERVTILVKQKDVL-SHGE 1486
            +   +   +L    K  +   +I +  L    +L+   RK+KE + I+++ +    S  E
Sbjct: 1420 IFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEE 1479

Query: 1487 KEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLG- 1545
            K +E ++ +   +       + +  LR       +   ++        E  S   LK+  
Sbjct: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539

Query: 1546 -TLNGSQEEMWQKTETVKQENAAVQKMVEN----LKKQISELKIKNQQLDLENTELSQKN 1600
             T+   Q  + QK E +K+    ++K  E     +KK   +L I + +L+L+      K 
Sbjct: 1540 QTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKF 1599

Query: 1601 SQNQE-----------------KLQELNQRLTEM------LCQKEKEPGNSALEEREQEK 1637
             Q                    +L E+ Q + E       L  K K+       +RE  +
Sbjct: 1600 KQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITE 1659

Query: 1638 FNLKEELERCKVQ----SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLH-RC 1692
              +KE  E  K+Q        V  ++AE+ ++K      Q+E+  LK EL+  K+ + R 
Sbjct: 1660 LKVKE-FENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRA 1718

Query: 1693 P--DLSDFQQKISSVLSYNEK-----------LLKEKEALSEE--LNSCVDK---LAKSS 1734
            P   + +  +++ S L+  EK           L  E  A +EE  +++   K   L    
Sbjct: 1719 PTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ 1778

Query: 1735 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1794
            +++     +K + +        LK  L  S+ +  +L D + ++N ++ + +       +
Sbjct: 1779 IVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILR 1838

Query: 1795 EKEALKQEVMSLHKQLQN-AGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN------- 1846
            EKE + QE   L +Q++    G    P      S +   Q+++   KL++ +        
Sbjct: 1839 EKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK--KLENQLEGKVEEVD 1896

Query: 1847 ---------EEQQLLWQENERLQTMVQNTKAELTHSREKV----RQLES--NLLPKHQKH 1891
                     +E+ + W+E ++ Q  ++  + +L     +V    +QL +  +L  K  K 
Sbjct: 1897 LKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKE 1956

Query: 1892 ----LNPSGTMNPTEQEKLSLK-----RECDQFQKEQSPANRKVSQMNS-----LEQELE 1937
                     T   T  + L ++     +E ++ +K        +  M +      +  +E
Sbjct: 1957 KLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016

Query: 1938 TIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS-PHAWDLQLLQQQACPMVPREQFLQ 1996
             +HL+N  L++K   L++Q  +  + + + +   S  H    Q LQ++   +    + ++
Sbjct: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKL--SSENIE 2074

Query: 1997 LQRQLLQAERINQHLQEELENRTSETNTPQALLPEQRAVHADSYRRIGHL 2046
            L+ QL QA   N+ L   L+N+  +       L +++   A+  R++GH+
Sbjct: 2075 LKFQLEQA---NKDL-PRLKNQVRDLKEMCEFLKKEK---AEVQRKLGHV 2117



 Score =  149 bits (375), Expect = 4e-35
 Identities = 301/1518 (19%), Positives = 645/1518 (42%), Gaps = 195/1518 (12%)

Query: 304  HASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALA 363
            H   E I    Q E I    EI K    +++      E  L  E+ +   K SI  + + 
Sbjct: 995  HLECENISLKEQVESINKELEITKEKLHTIEQAWE-QETKLGNESSMDKAKKSITNSDIV 1053

Query: 364  SFKAEIRHL-------LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNE 416
            S   +I  L        +R +   +  E LR+ L + E+       E++   A + + N 
Sbjct: 1054 SISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNF----ELETKFAELTKIN- 1108

Query: 417  YNLRKLDEEYKERIA--ALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
             + +K+++  ++ +A    K     +R++IL+   K  +EL+ E+ K +   +  R ++ 
Sbjct: 1109 LDAQKVEQMLRDELADSVSKAVSDADRQRILELE-KNEMELKVEVSKLREISDIARRQVE 1167

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
            +   +    + E+     +L +Y+  ++  +++L   L +    L  S A    + E +T
Sbjct: 1168 ILNAQQQSRDKEVESLRMQLLDYQAQSD--EKSLIAKLHQHNVSLQLSEATALGKLESIT 1225

Query: 535  QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG 594
                + E     L+ ++DE +  L   R +GR     L+ +  + +     G  P     
Sbjct: 1226 SKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQT-IQSLRRQFSGALPLAQQE 1284

Query: 595  SEECNPLNMSIEAELVIEQMK--EQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 652
                  + +  +   ++++MK  +Q HR++    LE+E K++  E +L  T+   K AQ+
Sbjct: 1285 KFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLE-ELISTLKDTKGAQK 1343

Query: 653  NMKQRHENETHTLEK------------QISDLKNEIAELQGQAAVLKEAHHEATCRHEEE 700
             +    + E   L++            +I  L N I+E +   + L+E   +    HEE 
Sbjct: 1344 VINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEER 1403

Query: 701  KKQLQVKLEEEKTHLQEKL----RLQHEMELKARL----------------TQAQASFER 740
                Q+  ++ +  L+ +L    R Q+E+   A+                  Q + +  +
Sbjct: 1404 ----QMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRK 1459

Query: 741  EREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL-------LEKHQ 793
             +E ++    T    + L ++L++  +E    L E++ L ++++  EL        E+ +
Sbjct: 1460 IKENIRIILETRATCKSLEEKLKE--KESALRLAEQNILSRDKVINELRLRLPATAEREK 1517

Query: 794  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 853
               + GR++ME + +  T +I  Q  ++ Q    + E  L+    +Y++ L+  +E+QRE
Sbjct: 1518 LIAELGRKEMEPK-SHHTLKIAHQTIANMQARLNQKEEVLK----KYQRLLEKAREEQRE 1572

Query: 854  EKSQWEFE------------KDELTQECAEAQELLKETLKREKTTS-LVLTQEREMLEKT 900
               + E +               L +    A +L+K++     T    +   E E     
Sbjct: 1573 IVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAE 1632

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSH-------KRELREREE 953
              + L+S++V+ +++ QDLE  R ++E +     +  L+L+ +H       K E+ + + 
Sbjct: 1633 QDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKY 1692

Query: 954  VLCQAGASEQLASQRLERLEMEHDQER--------QEMMSKLLAMENIHKATCETADRER 1005
            +L Q+    Q     L+  +  + +          + + S+L   E   KA        R
Sbjct: 1693 LLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELR 1752

Query: 1006 AEMS--------TEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGE 1057
            AEM+        +  S+ ++ +   Q        L++  + + E  ++   AL   +  E
Sbjct: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRE 1812

Query: 1058 QLLEEN----GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPAT 1113
              L +N     + L   Q+A+ + ++E  ++  E   L++++++L  GL       +P T
Sbjct: 1813 NSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQ-----GKPLT 1867

Query: 1114 EFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDL------GSTGTSSVQRQE 1167
            +   +  E+ +  +++    Q+EG      L  +++   ++       G    + ++   
Sbjct: 1868 DNKQSLIEELQRKVKKLEN-QLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIR 1926

Query: 1168 VKIEESEASVEGFSELENS---------EETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
             K++E E  V   ++  N+         +E  T   +LK     + + L +   + ++  
Sbjct: 1927 NKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKEL 1986

Query: 1219 E--KKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEA 1276
            E  KK++L  +  +L        R  +A P+  ++ ED+  +N  LQE+L  +E ++ + 
Sbjct: 1987 EELKKRNLDLENDILYM------RAHQALPRDSVV-EDLHLQNRYLQEKLHALEKQFSKD 2039

Query: 1277 LENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQ 1336
              +   ++       D  ++ +E+ +  L L     E+K + E+ N  + RL+ ++  L+
Sbjct: 2040 TYSKPSISG--IESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLK 2097

Query: 1337 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYL-- 1394
            E     C+    E +    ++       +  +T+ E    +  +  V+E+ ++EN+ L  
Sbjct: 2098 EM----CEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKK 2153

Query: 1395 --------------EGNTQL---LEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1437
                          + N +L   LEK+KAH    L   +  H E      + I+ EN  L
Sbjct: 2154 ASGILTSEKMANIEQENEKLKAELEKLKAH----LGHQLSMHYESKTKGTEKIIAENERL 2209

Query: 1438 LGFQDKHFQHQATIAE-LELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMH 1496
                 K  + +   AE L + K  L+ L     E++T+ +++      G++ +  ++   
Sbjct: 2210 R----KELKKETDAAEKLRIAKNNLEILN----EKMTVQLEET-----GKRLQFAESRGP 2256

Query: 1497 DLQITCSEMQQKVELLR-YESEKLQQENSILRNE--ITTLNEEDSISNLKLGTLNGSQEE 1553
             L+   S+  + + + R YE++  + E  I +    IT L +    +  +   +N   E+
Sbjct: 2257 QLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNED 2316

Query: 1554 MWQKTETVKQ--ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKL-QEL 1610
            + Q+ + +K   E A  +   + LK+++  L++ N QLD E  EL  +   N+++   E 
Sbjct: 2317 LEQQIKILKHVPEGAETE---QGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAES 2373

Query: 1611 NQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTH 1670
                 + L +K K+   + L+  + EK +LKEE+++ K +      S   E+ ++K    
Sbjct: 2374 TIPDADQLKEKIKDL-ETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYK 2432

Query: 1671 IVQQENHLLKDELEKMKQ 1688
               ++N LL+++++K+ +
Sbjct: 2433 EEVKKNILLEEKVKKLSE 2450



 Score =  140 bits (354), Expect = 1e-32
 Identities = 306/1566 (19%), Positives = 642/1566 (40%), Gaps = 257/1566 (16%)

Query: 435  NELRKERE----------QILQQAGKQRLELE-QEIEKAKTEENYIRDRLALSLKENSRL 483
            NEL+ E++          Q L +   Q +EL  +E+EKA  E+    ++L   +    +L
Sbjct: 38   NELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVM---KL 94

Query: 484  ENELLENAEKLA---EYENLTNKLQRNLENVLAEKFGDLDPSSAEF----------FLQE 530
            ENEL E A++ A   +   L N++ + LE  L +K  +L+    E            L+ 
Sbjct: 95   ENEL-EMAQQSAGGRDTRFLRNEICQ-LEKQLEQKDRELEDMEKELEKEKKVNEQLALRN 152

Query: 531  ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
            E      ++  R+ + L+ + ++L  ++ +Y+ Q    +  L +   E+ +  S   +  
Sbjct: 153  EEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKN 212

Query: 591  HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
            + L  +  + +    EA   IE   ++       +R  LE+ V+  EK  DE        
Sbjct: 213  YEL-IQYLDEIQTLTEANEKIEVQNQE-------MRKNLEESVQEMEKMTDEY-----NR 259

Query: 651  QENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHE------ATCRHEEEKKQL 704
             + +  + +N    L+K+    + ++ EL     +LK  + E      A     EE K +
Sbjct: 260  MKAIVHQTDNVIDQLKKENDHYQLQVQELTD---LLKSKNEEDDPIMVAVNAKVEEWKLI 316

Query: 705  QVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ 764
                ++E    Q+ L    E    A+L   +++    ++G+Q     + +++ LT+++EQ
Sbjct: 317  LSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER---DSQIKMLTEQVEQ 373

Query: 765  FHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK 824
            + +E     +EK+T   E+L+ EL           R K  +  +++T           ++
Sbjct: 374  YTKE-----MEKNTCIIEDLKNELQ----------RNKGASTLSQQTHMKIQSTLDILKE 418

Query: 825  VTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREK 884
             T+  E   +  E   R++ K+L E  +  K   ++E      E A  +      +K  K
Sbjct: 419  KTKEAERTAELAEADAREKDKELVEALKRLK---DYESGVYGLEDAVVE------IKNCK 469

Query: 885  TTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSH 944
                +  +E E+L K     +N + ++    L + E LR     +   + D      S H
Sbjct: 470  NQIKIRDREIEILTK----EINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKH 525

Query: 945  KRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKL--LAMENIHKATCETAD 1002
             ++ + R E         Q+  + +E LE    +ER ++  K+  +A E   ++      
Sbjct: 526  LKQQQYRAE--------NQILLKEIESLE----EERLDLKKKIRQMAQERGKRSATSGLT 573

Query: 1003 RERAEMSTEISRLQSKIKEMQQ---ATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
             E   ++  IS+   +I E +    +   +S  QS  + +  E +E           E+ 
Sbjct: 574  TEDLNLTENISQ-GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEK----------ERD 622

Query: 1060 LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS---SCLDEPATEFF 1116
            LE +  V+   Q   ++ V+EN ++   +  + Q +++++    +    + L  P+ E  
Sbjct: 623  LERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERL 682

Query: 1117 GNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEAS 1176
             N  E          +K  EG+    +    + D++     TG +   RQE++  ES   
Sbjct: 683  VNAIE----------SKNAEGIFDASLHLKAQVDQL-----TGRNEELRQELR--ESRKE 725

Query: 1177 VEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRA-----------SEKKQDLL 1225
               +S+       + +  E +  + +  E   ++    D             + + + L+
Sbjct: 726  AINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLI 785

Query: 1226 FDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTA 1285
              +  L+ K K L+ + ++   Y   +  +  +   L          Y E L   +    
Sbjct: 786  HLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLL----------YKEYLSEKETWKT 835

Query: 1286 EVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDC 1345
            E   +++E +K+E+  +         D +K++  E N L+  LQ   +++++ + +    
Sbjct: 836  ESKTIKEEKRKLEDQVQQ--------DAIKVK--EYNNLLNALQMDSDEMKKILAEN--- 882

Query: 1346 CLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVK 1405
                  +  L++     I Q   TL E   ++R      E  KQ+N+ L    ++ EK+ 
Sbjct: 883  ---SRKITVLQVNEKSLIRQYT-TLVELERQLRK-----ENEKQKNELLSMEAEVCEKI- 932

Query: 1406 AHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELT 1465
                    G +Q  +E    +   +            K   +  +++ELEL   +  ELT
Sbjct: 933  --------GCLQRFKEMAIFKIAAL-----------QKVVDNSVSLSELELANKQYNELT 973

Query: 1466 RKLKE---RVTILVKQKDVLSHGEKE-----EELKAMMHDLQITCSEMQQKVELLRYESE 1517
             K ++   +  +LV++   L H E E     E+++++  +L+IT  ++        +  E
Sbjct: 974  AKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKL--------HTIE 1025

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            +  ++ + L NE +    + SI+N  + +++     +  K    +Q     QKM E+L+ 
Sbjct: 1026 QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRT 1085

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
             + +++ +N +L+ +  EL++ N   Q+  Q L   L + + +   +     + E E+ +
Sbjct: 1086 SLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNE 1145

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEV-KIQTHIVQQENHLLKDELEKMK-QLHRCPDL 1695
              LK E+ + +            E+S++ + Q  I+  +      E+E ++ QL      
Sbjct: 1146 MELKVEVSKLR------------EISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQ 1193

Query: 1696 SDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSA 1755
            SD +  I+ +  +N  L   +     +L S   KL K      R+     EQK  E + A
Sbjct: 1194 SDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRL-----EQKLDEKEQA 1248

Query: 1756 SLKSQLVASQEKVQNLEDTVQNVNLQMS---------RMKSDLRVTQQEKEALKQEVMSL 1806
               ++L   + + ++L  T+Q++  Q S         +    +   Q +K  + QE+ + 
Sbjct: 1249 LYYARL-EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNS 1307

Query: 1807 HKQLQNAGGKS--------WAPEIATHPSGLHNQQKRLSWD-KLDHLMNEEQQL---LWQ 1854
             ++ +N   K+           E+ +        QK ++W  K++ L  +E +L   L +
Sbjct: 1308 QQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVK 1367

Query: 1855 ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1914
            + E ++  + N  +E   +   +  LE  ++ +++ H          +Q ++ L+R+ D 
Sbjct: 1368 DKEEIK-YLNNIISEYERT---ISSLEEEIVQQNKFH---EERQMAWDQREVDLERQLDI 1420

Query: 1915 FQKEQS 1920
            F ++Q+
Sbjct: 1421 FDRQQN 1426



 Score =  134 bits (336), Expect = 1e-30
 Identities = 359/1879 (19%), Positives = 753/1879 (40%), Gaps = 292/1879 (15%)

Query: 320  ENSQEILKAL-DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQ 378
            E  +EIL+A+ +   D ++   E +L + +   +      + A   F A + HL  +VDQ
Sbjct: 649  EGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASL-HLKAQVDQ 707

Query: 379  VVREKEKLRSDL---------------------DKAEKLKSLMASEVDDH---------- 407
            +    E+LR +L                     D  EK  SL+      +          
Sbjct: 708  LTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPD 767

Query: 408  ------HAAIERRNEYNLRKLDE-EYKER-IAALKNELRKEREQILQQAGKQRL---ELE 456
                   + I  +NEY +  L E E KE+ +  L++ L     +      +Q L   E  
Sbjct: 768  GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYL 827

Query: 457  QEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRN---LENVLA 513
             E E  KTE   I++       E  +LE+++ ++A K+ EY NL N LQ +   ++ +LA
Sbjct: 828  SEKETWKTESKTIKE-------EKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILA 880

Query: 514  E---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL-EEYRAQGRVLR 569
            E   K   L  +      Q   L ++  +  ++    ++++  +++E+ E+     R   
Sbjct: 881  ENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKE 940

Query: 570  LPL-KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDIC---CL 625
            + + K +  ++V  NS  +  E  L +++ N L       L  + M  Q   ++    C 
Sbjct: 941  MAIFKIAALQKVVDNSVSLS-ELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECE 999

Query: 626  RLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 685
             + L+++V    K+L+ T    K+    ++Q  E ET         L NE +  + + ++
Sbjct: 1000 NISLKEQVESINKELEIT----KEKLHTIEQAWEQETK--------LGNESSMDKAKKSI 1047

Query: 686  LKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGL 745
                    +      KK   ++++E    L E+ R +H  ++   L  +    E     L
Sbjct: 1048 TNSDIVSIS------KKITMLEMKE----LNERQRAEHCQKMYEHLRTSLKQMEERNFEL 1097

Query: 746  QSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMET 805
            ++      K+    Q++EQ  +++L   V K   + +  R   LEK++ EL+    K+  
Sbjct: 1098 ETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLRE 1157

Query: 806  ECNRRTSQIE---AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEK 862
              +    Q+E   AQ QS  ++V        +SL    R +L D Q Q  E+    +  +
Sbjct: 1158 ISDIARRQVEILNAQQQSRDKEV--------ESL----RMQLLDYQAQSDEKSLIAKLHQ 1205

Query: 863  DELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQ--DLE 920
              ++ + +EA  L K     E  TS +   E       Y   L   + E++Q L    LE
Sbjct: 1206 HNVSLQLSEATALGK----LESITSKLQKME------AYNLRLEQKLDEKEQALYYARLE 1255

Query: 921  DLRNVSETQQSLLSDQILELKSSHKRELREREE---VLCQAGASEQLASQRLERLEMEHD 977
                    +Q++   Q L  + S    L ++E+    + Q    +    Q ++  + EH 
Sbjct: 1256 GRNRAKHLRQTI---QSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHR 1312

Query: 978  QERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQ 1037
                + +   L ++ + +      D + A+   ++     KI+E++     L  L+   +
Sbjct: 1313 NMENKTLEMELKLKGLEELISTLKDTKGAQ---KVINWHMKIEELR-----LQELKLNRE 1364

Query: 1038 VIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK 1097
            ++ ++E E     +++ + E+ +    + ++   + HE+      +   ++ R      +
Sbjct: 1365 LVKDKE-EIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDR 1423

Query: 1098 LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGS 1157
             +  ++ ++   E AT   G+  + + P        Q+E   R+        + +R +  
Sbjct: 1424 QQNEILNAAQKFEEAT---GSIPDPSLPL-----PNQLEIALRKI------KENIRIILE 1469

Query: 1158 TGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRA 1217
            T  +    +E K++E E+++    +   S +       L+   +  +E+L+      +  
Sbjct: 1470 TRATCKSLEE-KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEME 1528

Query: 1218 SEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL----QEELRMMETRY 1273
             +    L      +      L +  E   KY+ L E    E   +    +E+L ++  R 
Sbjct: 1529 PKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRL 1588

Query: 1274 D-EALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKI 1332
            + +A  +  +     + L  +        + F+ L +    V  +++ L+ L+++L+   
Sbjct: 1589 ELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVS 1648

Query: 1333 EKLQESVVQRCDCCLWEASLENLEIEPDGNI-LQLNQTLEECVPRVRS----VHHVIEEC 1387
            + L+            +  +  L+++   NI LQL +  E+ V +V++    + +++++ 
Sbjct: 1649 QDLER-----------QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQS 1697

Query: 1388 KQENQYLEGNTQLLEKVKAHE--------IAWLHGTIQTHQERPRVQNQVILEENTTLLG 1439
            ++E+Q L+   Q  ++  +          +  L   +   +++ +  ++ +LE    +  
Sbjct: 1698 QKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTA 1757

Query: 1440 FQDKHFQHQATIAELELEKTKLQEL-TRKLKERVTIL----VKQKDVLSHGE-KEEELKA 1493
              ++      +  E  L   ++ +  TR+LK +V  L    +K K+ L   + +E  L  
Sbjct: 1758 AAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTD 1817

Query: 1494 MMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL-----------NEEDSISNL 1542
             ++DL     + Q+    +  E E++ QEN  L+ +I  L           N++  I  L
Sbjct: 1818 NLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEEL 1877

Query: 1543 KL------GTLNGSQEEM----------------------WQ-KTETVKQENAAVQKMVE 1573
            +         L G  EE+                      WQ K E ++ +    +  V 
Sbjct: 1878 QRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVF 1937

Query: 1574 NLKKQISELKIKNQQLDLENTELSQKNS---------------QNQEKLQELNQRLTEM- 1617
             L KQ++ LK    + D E   L +K                 +++++L+EL +R  ++ 
Sbjct: 1938 TLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLE 1997

Query: 1618 -----LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHI- 1671
                 +   +  P +S +E+   +   L+E+L   + Q S    S +  +S ++   H  
Sbjct: 1998 NDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYS-KPSISGIESDDHCQ 2056

Query: 1672 ----VQQENHLLKDELEKMK-QLHRC-PDLSDFQQKISSVLSYNEKLLKEKEALSEELNS 1725
                +Q+EN  L  E  ++K QL +   DL   + ++  +    E L KEK  +  +L  
Sbjct: 2057 REQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGH 2116

Query: 1726 CVDKLAKSSL---LEHRIATMKQEQKSWEHQSASLKSQL-VASQEKVQNLEDTVQNVNLQ 1781
                         LE  I  MK+  +  + ++  LK    + + EK+ N+E   + +  +
Sbjct: 2117 VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAE 2176

Query: 1782 MSRMKSDL--------RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQ 1833
            + ++K+ L            +  E +  E   L K+L+     +    IA +   + N++
Sbjct: 2177 LEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEK 2236

Query: 1834 KRLSWD----KLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1889
              +  +    +L    +   QL   +++  +++V     E      K+++LE+++  K+Q
Sbjct: 2237 MTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYET-----KLKELETDIAKKNQ 2291

Query: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNS-LEQELETIHLENEGLKK 1948
                                 +  Q  KE +   +KV++ N  LEQ+++ +    EG + 
Sbjct: 2292 SIT------------------DLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAET 2333

Query: 1949 KQ-VKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVP-----REQFLQLQRQLL 2002
            +Q +K + Q++ + + +     +   H  +    Q  A   +P     +E+   L+ QL 
Sbjct: 2334 EQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLK 2393

Query: 2003 QAERINQHLQEELENRTSE 2021
             ++   QHL+EE++    E
Sbjct: 2394 MSDLEKQHLKEEIKKLKKE 2412



 Score =  131 bits (330), Expect = 6e-30
 Identities = 370/1818 (20%), Positives = 733/1818 (40%), Gaps = 261/1818 (14%)

Query: 326  LKALDFSLDGNINLTELTLALENELLVT----KNSIHQAALASFKAEIRHLLERVDQVVR 381
            LK  DF LD N  L E  + LE + ++     +NS H      ++AE + LL+ ++ +  
Sbjct: 491  LKISDF-LDENEALRE-RVGLEPKTMIDLTEFRNSKHLKQ-QQYRAENQILLKEIESLEE 547

Query: 382  E----KEKLRSDLDKAEKLKSLMASEVDDHHAA--IERRNEYNLRKLDEEYKERIAALKN 435
            E    K+K+R    +  K  +      +D +    I + +  + RKLD      + +LKN
Sbjct: 548  ERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLD------LLSLKN 601

Query: 436  ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLA 495
                E +   +   ++ +E E+++E+++T     +++L   ++EN +LE  + E  + + 
Sbjct: 602  --MSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIK 659

Query: 496  EYEN-----------LTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 544
            E +            +   L+R +  + ++    +  +S     Q ++LT    E  ++ 
Sbjct: 660  EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL 719

Query: 545  RVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANS---GGIEPEHGLGSEECNPL 601
            R  + +      +L   +A  ++  L  + S   + E ++    GI+   G+     + +
Sbjct: 720  RESRKEAINYSQQLA--KANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASII 777

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDK------VRHYEKQLDETVVSCKKAQENMK 655
            N   E  + + Q  E   + +  L   LED       +RH +  L +  +S K+  +   
Sbjct: 778  NSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTES 837

Query: 656  QRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT-- 713
            +  + E   LE Q+     ++ E       L+    E      E  +++ V    EK+  
Sbjct: 838  KTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897

Query: 714  -------HLQEKLRLQHE------MELKARLTQAQASFERERE----------------- 743
                    L+ +LR ++E      + ++A + +     +R +E                 
Sbjct: 898  RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957

Query: 744  GLQSSAWTEEKVRGLTQELEQFHQE-----QLTSLVEKHTLEKEELRKELLEKHQRELQE 798
             L       ++   LT +     Q+     Q TS +E    E   L KE +E   +EL+ 
Sbjct: 958  SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISL-KEQVESINKELEI 1016

Query: 799  GREKMETECNRRTSQIEAQFQSDCQKVTERC-ESALQSLEGRYRQ-ELKDLQEQQREEKS 856
             +EK+ T       + +   +S   K  +    S + S+  +    E+K+L E+QR E  
Sbjct: 1017 TKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAE-- 1074

Query: 857  QWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLL 916
                        C +  E L+ +LK+ +  +  L  E +  E T K +L++  VE Q L 
Sbjct: 1075 -----------HCQKMYEHLRTSLKQMEERNFEL--ETKFAELT-KINLDAQKVE-QMLR 1119

Query: 917  QDLEDLRNVSETQQSLLSDQILELKS---------SHKREL----REREEVLC--QAGAS 961
             +L D  +VS+        +ILEL+          S  RE+    R + E+L   Q    
Sbjct: 1120 DELAD--SVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRD 1177

Query: 962  EQLASQRLERLEMEHDQERQEMMSKLLAME---NIHKATC----ETADRERAEMSTEISR 1014
            +++ S R++ L+ +   + + +++KL        + +AT     E+   +  +M     R
Sbjct: 1178 KEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLR 1237

Query: 1015 LQSKIKEMQQAT-----SPLSMLQSGCQVIGEEEVEGDGALSLLQQ---GEQLLEENGDV 1066
            L+ K+ E +QA         +  +   Q I     +  GAL L QQ    + +++   D 
Sbjct: 1238 LEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDK 1297

Query: 1067 LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPF 1126
            L  +Q   + + +E+  M  +   ++ +L+ LE   ++S+  D    +   N   + E  
Sbjct: 1298 LKIMQEM-KNSQQEHRNMENKTLEMELKLKGLEE--LISTLKDTKGAQKVINWHMKIEEL 1354

Query: 1127 LQQNRTKQVEGVTRRH---VLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSEL 1183
              Q      E V  +     L+++  +  R + S     VQ+ +   E   A  +   +L
Sbjct: 1355 RLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDL 1414

Query: 1184 ENS--------EETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL 1235
            E           E    + + +     + +  + L    + A  K ++ +  +   +   
Sbjct: 1415 ERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATC 1474

Query: 1236 KMLE-RIPEASPKYKLLYEDVSRENDCLQE-ELRMMETRYDEALE---NNKELTAE---- 1286
            K LE ++ E     +L  +++   +  + E  LR+  T   E L      KE+  +    
Sbjct: 1475 KSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHT 1534

Query: 1287 -------VFRLQDELKKMEEVTETFLSL-EKSYDE----VKIENEELNVLVLRLQGKIEK 1334
                   +  +Q  L + EEV + +  L EK+ +E    VK   E+L++L  RL    E 
Sbjct: 1535 LKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRL----EL 1590

Query: 1335 LQESVVQRCDCCLWEASLEN-LEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
              +S + +     W+   ++   +  + + ++L +  +    +  S+  ++ + K+ +Q 
Sbjct: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQD 1650

Query: 1394 LEGNTQLLE-KVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1452
            LE   ++ E KVK  E   L        E  +V+ +V  E+   LL    K  + Q   +
Sbjct: 1651 LERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV--EDLKYLLDQSQK--ESQCLKS 1706

Query: 1453 ELELEK--------TKLQELTRKLKERVTILVKQKDVLSHG--EKEEELKAMMHDLQITC 1502
            EL+ +K        T ++ L  +LK ++ +  KQ+  LS    E   E+ A   +  I+ 
Sbjct: 1707 ELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISA 1766

Query: 1503 SE-------MQQKVEL----LRYESEKLQQENSILRNEI-TTLNEEDSISNLKLGTLNGS 1550
            +        +QQ V+     L+ + E L +    L+  + T+ N E+S+++  L  LN  
Sbjct: 1767 TSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTD-NLNDLNNE 1825

Query: 1551 QEEMWQKTETVKQENAAVQKMVENLKKQISELK--------IKNQQLDLENTELSQKNSQ 1602
             ++  +    + +E   + +  + LK+QI  L           N+Q  +E  +   K  +
Sbjct: 1826 LQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885

Query: 1603 NQ--EKLQELNQRLTEMLCQKEK--------------EPGNSALEEREQEKFNLKEELER 1646
            NQ   K++E++ +  +    KE+              E   + L+E+E E F L ++L  
Sbjct: 1886 NQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNT 1945

Query: 1647 CK---VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD-ELEKMKQLHRCPDLSDFQQKI 1702
             K    ++     +L+ +L    +    V     L  + ELE++K+ +   +      + 
Sbjct: 1946 LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRA 2005

Query: 1703 SSVL---SYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKS 1759
               L   S  E L  +   L E+L++   + +K +  +  I+ ++ +      Q    K 
Sbjct: 2006 HQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQ-KE 2064

Query: 1760 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWA 1819
             L  S E ++ L+  ++  N  + R+K+ +R  ++  E LK+E   + ++L +  G   +
Sbjct: 2065 NLKLSSENIE-LKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS 2123

Query: 1820 ----PEIATHPSGLHN-----QQKRLSWDKLDHLMNEEQQL-LWQENERLQTMVQNTKAE 1869
                PE+      +       Q++     K   ++  E+   + QENE+L+  ++  KA 
Sbjct: 2124 GKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAH 2183

Query: 1870 LTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL--SLKRECDQFQKEQSPANRKVS 1927
            L H            L  H +           E E+L   LK+E D  +K +   N    
Sbjct: 2184 LGHQ-----------LSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNL-- 2230

Query: 1928 QMNSLEQELETIHLENEG 1945
                +  E  T+ LE  G
Sbjct: 2231 ---EILNEKMTVQLEETG 2245



 Score =  111 bits (278), Expect = 6e-24
 Identities = 256/1300 (19%), Positives = 535/1300 (41%), Gaps = 250/1300 (19%)

Query: 411  IERRNEYNLR---KLDE-EYKERIAALKNELR-KEREQILQQAGKQ---RLELEQEIEKA 462
            +++   YNLR   KLDE E     A L+   R K   Q +Q   +Q    L L Q+ + +
Sbjct: 1228 LQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFS 1287

Query: 463  KTEENYIRDRLAL------SLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKF 516
            KT      D+L +      S +E+  +EN+ LE   KL   E L + L+   +   A+K 
Sbjct: 1288 KTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLK---DTKGAQKV 1344

Query: 517  GDLDPSSAEFFLQEERLTQ--------------MRNEYERQCRVLQDQVDELQSELEEYR 562
             +      E  LQE +L +              + +EYER    L++++ +     EE +
Sbjct: 1345 INWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQ 1404

Query: 563  AQGRVLRLPLKNS----PSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQH 618
                   + L+        ++ E  +   + E   GS     L +  + E+ + ++KE  
Sbjct: 1405 MAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKEN- 1463

Query: 619  HRDICCLRLELEDKV--RHYEKQLDETVVSCKKAQENMKQRHE--NETHTLEKQISDLKN 674
                  +R+ LE +   +  E++L E   + + A++N+  R +  NE        ++ + 
Sbjct: 1464 ------IRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREK 1517

Query: 675  EIAELQGQAAVLKEAHHEATCRHE---------------------------EEKKQLQVK 707
             IAEL G+  +  ++HH     H+                           EE++++  K
Sbjct: 1518 LIAEL-GRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKK 1576

Query: 708  LEEEKTHLQEKLRLQHEMELKARLTQA-------------QASFEREREGLQSSAWTEEK 754
             EE+   L  +L LQ +  L      A                F R  E  Q+ A  ++ 
Sbjct: 1577 HEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDS 1636

Query: 755  VRGLTQELEQFHQ--EQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMET------E 806
            +  L  +L++  Q  E+   + E    E E ++ +L E H+ E+++ + ++E       +
Sbjct: 1637 LSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQ 1696

Query: 807  CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFE-KDEL 865
              + +  ++++ Q+  +  +    + +++L  R + +L  L+E+Q++  S+   E + E+
Sbjct: 1697 SQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLA-LKEKQQKALSRALLELRAEM 1755

Query: 866  TQECAEAQELLKETLKREKTTSLVLTQEREMLE-KTYKEHLNSMVVERQQLLQDLEDLRN 924
            T   A  + ++  T ++E   ++    +R   E KT  E LN  +++ ++ L+  ++  N
Sbjct: 1756 T--AAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNREN 1813

Query: 925  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQER---- 980
                  + L++++ + + ++ + LRE+EE+  +    ++   +    L+ +   +     
Sbjct: 1814 SLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSL 1873

Query: 981  -QEMMSKLLAMENIHKATCETAD----------------RERAEMSTEISRLQSKIKEMQ 1023
             +E+  K+  +EN  +   E  D                 E  +   +I  +++K+KE +
Sbjct: 1874 IEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKE 1933

Query: 1024 QATSPLSM------------------LQSGCQVIGE--EEVEGDGALSLLQQGEQLLEEN 1063
                 L+                   LQ   +  G   ++V G  AL   ++ E+L + N
Sbjct: 1934 GEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRN 1993

Query: 1064 GDVLLSL--QRAHEQAVKENVKMATEISR--LQQRLQKLEPGLVMSSCLDEPATEFFGNT 1119
             D+   +   RAH+   +++V     +    LQ++L  LE              +F  +T
Sbjct: 1994 LDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEK-------------QFSKDT 2040

Query: 1120 AEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG 1179
              +                     +S +E D+            + QE++ E  + S E 
Sbjct: 2041 YSKPS-------------------ISGIESDD---------HCQREQELQKENLKLSSEN 2072

Query: 1180 FSELENSEETRTESWELKNQISQLQEQLMMLCAD-------------CDRASEKKQDLLF 1226
                   E+   +   LKNQ+  L+E    L  +               R+ +   +L  
Sbjct: 2073 IELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEK 2132

Query: 1227 DVSVLKKKLKMLERIPEASPKYKLLYE-----DVSRENDCLQEELRMMETR--------Y 1273
             + ++KK ++ ++R  E   K   +       ++ +EN+ L+ EL  ++          Y
Sbjct: 2133 TIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHY 2192

Query: 1274 DEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL------- 1326
            +   +  +++ AE  RL+ ELKK  +  E    L  + + ++I NE++ V +        
Sbjct: 2193 ESKTKGTEKIIAENERLRKELKKETDAAE---KLRIAKNNLEILNEKMTVQLEETGKRLQ 2249

Query: 1327 -------RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRS 1379
                   +L+G   K  +S+V      ++E  L+ LE +    I + NQ++ +    V+ 
Sbjct: 2250 FAESRGPQLEGADSKSWKSIVVTR---MYETKLKELETD----IAKKNQSITDLKQLVKE 2302

Query: 1380 VHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLG 1439
                 ++  + N+ LE   ++L+ V   E A     ++   +  R+ N  + +E   L+ 
Sbjct: 2303 ATEREQKVNKYNEDLEQQIKILKHVP--EGAETEQGLKRELQVLRLANHQLDKEKAELIH 2360

Query: 1440 FQDKHFQH---QATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMH 1496
              + +      ++TI + +  K K+++L  +LK  ++ L KQ         +EE+K +  
Sbjct: 2361 QIEANKDQSGAESTIPDADQLKEKIKDLETQLK--MSDLEKQ-------HLKEEIKKLKK 2411

Query: 1497 DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE 1536
            +L+       +++E L+Y  ++  ++N +L  ++  L+E+
Sbjct: 2412 ELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQ 2451



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 226/1145 (19%), Positives = 463/1145 (40%), Gaps = 218/1145 (19%)

Query: 307  VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 366
            +ER LD +  +      EIL A     +   ++ + +L L N+L        + AL   K
Sbjct: 1414 LERQLDIFDRQ----QNEILNAAQKFEEATGSIPDPSLPLPNQL--------EIALRKIK 1461

Query: 367  AEIRHLLER------VDQVVREKE------------------KLRSDLDKAEKLKSLMAS 402
              IR +LE       +++ ++EKE                  +LR  L    + + L+A 
Sbjct: 1462 ENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIA- 1520

Query: 403  EVDDHHAAIERRNEYNLRKLDEEYKERIAAL--KNELRKEREQILQQAGKQRLELEQEIE 460
              +     +E ++ + L+   +      A L  K E+ K+ +++L++A +++ E+   ++
Sbjct: 1521 --ELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREI---VK 1575

Query: 461  KAKTEENYIRDRLAL----SLKENSRLENELLENAE----------KLAEYENLTNKLQR 506
            K + + + +  RL L    SL +  +   +L++ +           +LAE E    +   
Sbjct: 1576 KHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDD 1635

Query: 507  NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ----DQVDELQSELEEYR 562
            +L ++L +    L   S +   Q E       E+E     LQ    D+V ++++E+E+ +
Sbjct: 1636 SLSSLLVK----LKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLK 1691

Query: 563  A---QGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHH 619
                Q +     LK+    + EANS          +     L   ++++L +   KE+  
Sbjct: 1692 YLLDQSQKESQCLKSELQAQKEANSRA-------PTTTMRNLVERLKSQLAL---KEKQQ 1741

Query: 620  RDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAEL 679
            + +    LEL  ++    ++   +  S K+A  N++Q  +  T  L+ Q+ DL   + +L
Sbjct: 1742 KALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKL 1801

Query: 680  QGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFE 739
            +      K   +  T    +   +LQ K +     L+EK  +  E +      + +   +
Sbjct: 1802 KEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEND------ELKRQIK 1855

Query: 740  REREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG 799
            R   GLQ    T+ K                 SL+E                   ELQ  
Sbjct: 1856 RLTSGLQGKPLTDNK----------------QSLIE-------------------ELQRK 1880

Query: 800  REKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG-RYRQELKDLQEQQREEKSQW 858
             +K+E +   +  +++ +      K     E  ++  EG +++ +++ ++ + +E+    
Sbjct: 1881 VKKLENQLEGKVEEVDLK----PMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEK---- 1932

Query: 859  EFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQD 918
            E E   LT++       LK+   +     L L ++ +    T  + L    +E ++ L++
Sbjct: 1933 EGEVFTLTKQL----NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEE 1988

Query: 919  LE----DLRN---VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER 971
            L+    DL N        Q+L  D ++E      R L+E+   L +  + +  +   +  
Sbjct: 1989 LKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISG 2048

Query: 972  LEM-EHDQERQEMMSK--LLAMENIH----------------------KATCETADRERA 1006
            +E  +H Q  QE+  +   L+ ENI                       K  CE   +E+A
Sbjct: 2049 IESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKA 2108

Query: 1007 EMSTEISRLQSK------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL------SLLQ 1054
            E+  ++  ++        I E+++    +  +    Q   E+  +  G L      ++ Q
Sbjct: 2109 EVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQ 2168

Query: 1055 QGEQLLEE----NGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDE 1110
            + E+L  E       +   L   +E   K   K+  E  RL++ L+K           + 
Sbjct: 2169 ENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK-----------ET 2217

Query: 1111 PATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV---QRQE 1167
             A E     A+     L +  T Q+E   +R   ++    ++    S    S+   +  E
Sbjct: 2218 DAAEKL-RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE 2276

Query: 1168 VKIEESEASV----EGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQD 1223
             K++E E  +    +  ++L+   +  TE  +  N+ ++  EQ + +       +E +Q 
Sbjct: 2277 TKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQG 2336

Query: 1224 LLFDVSVL--------KKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
            L  ++ VL        K+K +++ +I EA+ K +   E    + D L+E+++ +ET+   
Sbjct: 2337 LKRELQVLRLANHQLDKEKAELIHQI-EAN-KDQSGAESTIPDADQLKEKIKDLETQL-- 2392

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETF-LSLEKSYDEVKIENEELNVLVLRLQGKIEK 1334
                 K    E   L++E+KK+++  E F  S  +  +++K   +E     + L+ K++K
Sbjct: 2393 -----KMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKK 2447

Query: 1335 LQESV 1339
            L E +
Sbjct: 2448 LSEQL 2452


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,854,154
Number of Sequences: 37866
Number of extensions: 3541625
Number of successful extensions: 48276
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 492
Number of HSP's successfully gapped in prelim test: 1535
Number of HSP's that attempted gapping in prelim test: 15894
Number of HSP's gapped (non-prelim): 14009
length of query: 2046
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1928
effective length of database: 13,779,330
effective search space: 26566548240
effective search space used: 26566548240
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.