Search of human proteins with 148536869

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148536869 ninein isoform 2 [Homo sapiens]
         (2133 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148536869 ninein isoform 2 [Homo sapiens]                         4163   0.0  
gi|33946321 ninein isoform 5 [Homo sapiens]                          4033   0.0  
gi|33946313 ninein isoform 4 [Homo sapiens]                          3964   0.0  
gi|148536871 ninein isoform 1 [Homo sapiens]                         3962   0.0  
gi|55749678 ninein-like [Homo sapiens]                                455   e-127
gi|21735548 centrosomal protein 2 [Homo sapiens]                      213   2e-54
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    213   2e-54
gi|148746195 trichohyalin [Homo sapiens]                              207   9e-53
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   206   2e-52
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   206   2e-52
gi|71061468 centromere protein E [Homo sapiens]                       201   6e-51
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       176   2e-43
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       176   2e-43
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        176   2e-43
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        176   2e-43
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        176   2e-43
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        176   2e-43
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        176   2e-43
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        176   2e-43
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]    172   4e-42
gi|55770834 centromere protein F [Homo sapiens]                       171   7e-42
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            169   3e-41
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...   167   1e-40
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        160   1e-38
gi|109255234 centrosomal protein 290kDa [Homo sapiens]                159   4e-38
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   157   1e-37
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   157   1e-37
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    156   2e-37
gi|81295809 pericentrin [Homo sapiens]                                155   3e-37
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]        154   1e-36

>gi|148536869 ninein isoform 2 [Homo sapiens]
          Length = 2133

 Score = 4163 bits (10797), Expect = 0.0
 Identities = 2133/2133 (100%), Positives = 2133/2133 (100%)

Query: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
            MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
Sbjct: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60

Query: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120
            RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
Sbjct: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120

Query: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180
            PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
Sbjct: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180

Query: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240
            DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
Sbjct: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240

Query: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300
            DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
Sbjct: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300

Query: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360
            GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
Sbjct: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360

Query: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420
            ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
Sbjct: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420

Query: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480
            KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
Sbjct: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480

Query: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540
            SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
Sbjct: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540

Query: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
            ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
Sbjct: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600

Query: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
            LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
Sbjct: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660

Query: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
            ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
Sbjct: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720

Query: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780
            LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
Sbjct: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780

Query: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840
            KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY
Sbjct: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840

Query: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900
            RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
Sbjct: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960
            YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA
Sbjct: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960

Query: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020
            SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK
Sbjct: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020

Query: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080
            EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
Sbjct: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080

Query: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140
            NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR
Sbjct: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140

Query: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200
            RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI
Sbjct: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200

Query: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260
            SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND
Sbjct: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260

Query: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
            CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE
Sbjct: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320

Query: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380
            LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV
Sbjct: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380

Query: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440
            HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF
Sbjct: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440

Query: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500
            QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI
Sbjct: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500

Query: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560
            TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET
Sbjct: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560

Query: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620
            VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ
Sbjct: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620

Query: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680
            KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK
Sbjct: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680

Query: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740
            DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI
Sbjct: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740

Query: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800
            ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
Sbjct: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800

Query: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860
            QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ
Sbjct: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860

Query: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920
            TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS
Sbjct: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920

Query: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980
            PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
Sbjct: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980

Query: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERM 2040
            LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERM
Sbjct: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERM 2040

Query: 2041 IEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAE 2100
            IEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAE
Sbjct: 2041 IEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAE 2100

Query: 2101 KKNYLLEEKIASLSNIVRNLTPAPLTSTPPLRS 2133
            KKNYLLEEKIASLSNIVRNLTPAPLTSTPPLRS
Sbjct: 2101 KKNYLLEEKIASLSNIVRNLTPAPLTSTPPLRS 2133


>gi|33946321 ninein isoform 5 [Homo sapiens]
          Length = 2090

 Score = 4033 bits (10458), Expect = 0.0
 Identities = 2064/2065 (99%), Positives = 2065/2065 (100%)

Query: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
            MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
Sbjct: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60

Query: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120
            RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
Sbjct: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120

Query: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180
            PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
Sbjct: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180

Query: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240
            DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
Sbjct: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240

Query: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300
            DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
Sbjct: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300

Query: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360
            GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
Sbjct: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360

Query: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420
            ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
Sbjct: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420

Query: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480
            KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
Sbjct: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480

Query: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540
            SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
Sbjct: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540

Query: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
            ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
Sbjct: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600

Query: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
            LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
Sbjct: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660

Query: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
            ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
Sbjct: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720

Query: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780
            LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
Sbjct: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780

Query: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840
            KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY
Sbjct: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840

Query: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900
            RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
Sbjct: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960
            YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA
Sbjct: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960

Query: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020
            SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK
Sbjct: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020

Query: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080
            EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
Sbjct: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080

Query: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140
            NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR
Sbjct: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140

Query: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200
            RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI
Sbjct: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200

Query: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260
            SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND
Sbjct: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260

Query: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
            CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE
Sbjct: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320

Query: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380
            LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV
Sbjct: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380

Query: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440
            HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF
Sbjct: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440

Query: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500
            QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI
Sbjct: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500

Query: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560
            TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET
Sbjct: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560

Query: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620
            VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ
Sbjct: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620

Query: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680
            KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK
Sbjct: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680

Query: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740
            DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI
Sbjct: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740

Query: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800
            ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
Sbjct: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800

Query: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860
            QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ
Sbjct: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860

Query: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920
            TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS
Sbjct: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920

Query: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980
            PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
Sbjct: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980

Query: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERM 2040
            LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERM
Sbjct: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERM 2040

Query: 2041 IEVEQKLKLVKRLLQEKVNQLKEQL 2065
            IEVEQKLKLVKRLLQEKVNQLKEQ+
Sbjct: 2041 IEVEQKLKLVKRLLQEKVNQLKEQV 2065



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 253/1217 (20%), Positives = 489/1217 (40%), Gaps = 168/1217 (13%)

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEY-----KE 428
            E ++ +V E+++L  DL+    +     S + D    ++  ++  LR+ +E        E
Sbjct: 903  EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASE 962

Query: 429  RIAALKNE-LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENEL 487
            ++A+ + E L  E +Q  Q+   + L +E  I KA T E   R+R  +S  E SRL++++
Sbjct: 963  QLASQRLERLEMEHDQERQEMMSKLLAMEN-IHKA-TCETADRERAEMST-EISRLQSKI 1019

Query: 488  LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS-----SAEFFLQE--ERLTQMRNEY 540
             E  +  +    L +  Q     V+ E+  + D +       E  L+E  + L  ++  +
Sbjct: 1020 KEMQQATSPLSMLQSGCQ-----VIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAH 1074

Query: 541  ERQCRV---LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEE 597
            E+  +    +  ++  LQ  L++    G V+   L + P+ E   N+   + E  L    
Sbjct: 1075 EQAVKENVKMATEISRLQQRLQKLEP-GLVMSSCL-DEPATEFFGNTAE-QTEPFLQQNR 1131

Query: 598  CNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 657
               +   +    V+  +++   RD+          V+  E +++E+  S +   E ++  
Sbjct: 1132 TKQVE-GVTRRHVLSDLEDDEVRDLGSTGTS---SVQRQEVKIEESEASVEGFSE-LENS 1186

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQE 717
             E  T + E     LKN+I++LQ Q  +L      A C    EKKQ    L  + + L++
Sbjct: 1187 EETRTESWE-----LKNQISQLQEQLMMLC-----ADCDRASEKKQ---DLLFDVSVLKK 1233

Query: 718  KLRLQHEM-ELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK 776
            KL++   + E   +         RE + LQ      E++R +    ++  +       E 
Sbjct: 1234 KLKMLERIPEASPKYKLLYEDVSRENDCLQ------EELRMMETRYDEALENNKELTAEV 1287

Query: 777  HTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK----VTERC--- 829
              L+ E  + E + +    L++  ++++ E N   + +  + Q   +K    V +RC   
Sbjct: 1288 FRLQDELKKMEEVTETFLSLEKSYDEVKIE-NEELNVLVLRLQGKIEKLQESVVQRCDCC 1346

Query: 830  --ESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLK-ETLKREKTT 886
              E++L++LE      +  L  Q  EE          + +EC +  + L+  T   EK  
Sbjct: 1347 LWEASLENLEIEPDGNILQLN-QTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEK-- 1403

Query: 887  SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ---QSLLSDQILELKSS 943
              V   E   L  T + H     V+ Q +L++   L    +     Q+ +++  LE    
Sbjct: 1404 --VKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461

Query: 944  HK--RELREREEVLCQAGASEQLASQRLERLEMEHD--------QERQEMM---SKLLAM 990
             +  R+L+ER  +L +         +  E   M HD        Q++ E++   S+ L  
Sbjct: 1462 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1521

Query: 991  EN-IHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
            EN I +    T + E +  + ++  L    +EM Q T  +    +  Q + E   +    
Sbjct: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581

Query: 1050 LSLLQQ-----GEQLLEENGDVLLSLQRAHE-------QAVKENVKMATEISRLQQRL-- 1095
            L +  Q       +L ++N      LQ  ++       Q  KE    A E  R Q++   
Sbjct: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE-EREQEKFNL 1640

Query: 1096 -QKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGVTRRHVLSDLED--D 1150
             ++LE   V SS L             QT    Q+N     ++E + + H   DL D   
Sbjct: 1641 KEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQ 1700

Query: 1151 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSE---LENSEETRTE---SWELKNQISQLQ 1204
            ++  + S     ++ +E   EE  + V+  ++   LE+   T  +   SWE  +Q + L+
Sbjct: 1701 KISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWE--HQSASLK 1758

Query: 1205 EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK-----YKLLY------- 1252
             QL+          +  Q++   +S +K  L++ ++  EA  +     +K L        
Sbjct: 1759 SQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1818

Query: 1253 --EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1310
              E  +  +    ++ R+   + D  +   ++L   +++  + L+ M + T+     E +
Sbjct: 1819 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQL---LWQENERLQTMVQNTKA----ELT 1871

Query: 1311 YDEVKIENEELNVLV-----LRLQGKIEKLQE---SVVQRCDCCLWEASLENLEIEPDGN 1362
            +   K+   E N+L      L   G +   ++   S+ + CD    E S  N ++    +
Sbjct: 1872 HSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNS 1931

Query: 1363 ILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNT-----------QLLEK-----VKA 1406
            + Q  +T+      ++     ++E   E Q+L               QLL++     V  
Sbjct: 1932 LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1991

Query: 1407 HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAE---------LELE 1457
             +   L   +    ER     Q  LE  T+       + +   T+ E         L+L 
Sbjct: 1992 EQFLQLQRQL-LQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV 2050

Query: 1458 KTKLQELTRKLKERVTI 1474
            K  LQE   +LKE+V++
Sbjct: 2051 KRLLQEKVNQLKEQVSL 2067


>gi|33946313 ninein isoform 4 [Homo sapiens]
          Length = 2096

 Score = 3964 bits (10281), Expect = 0.0
 Identities = 2030/2036 (99%), Positives = 2032/2036 (99%)

Query: 30   QEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 89
            Q    +LCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD
Sbjct: 36   QHVKNELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 95

Query: 90   CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 149
            CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT
Sbjct: 96   CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 155

Query: 150  QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 209
            QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS
Sbjct: 156  QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 215

Query: 210  ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 269
            ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS
Sbjct: 216  ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 275

Query: 270  MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 329
            MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL
Sbjct: 276  MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 335

Query: 330  DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 389
            DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD
Sbjct: 336  DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 395

Query: 390  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 449
            LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG
Sbjct: 396  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 455

Query: 450  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509
            KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE
Sbjct: 456  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 515

Query: 510  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 569
            NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR
Sbjct: 516  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 575

Query: 570  LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 629
            LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL
Sbjct: 576  LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 635

Query: 630  EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689
            EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA
Sbjct: 636  EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 695

Query: 690  HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749
            HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA
Sbjct: 696  HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 755

Query: 750  WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 809
            WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR
Sbjct: 756  WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 815

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869
            RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC
Sbjct: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875

Query: 870  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929
            AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ
Sbjct: 876  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 935

Query: 930  QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
            QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA
Sbjct: 936  QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995

Query: 990  MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
            MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA
Sbjct: 996  MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055

Query: 1050 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1109
            LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD
Sbjct: 1056 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1115

Query: 1110 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1169
            EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK
Sbjct: 1116 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1175

Query: 1170 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1229
            IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS
Sbjct: 1176 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1235

Query: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289
            VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR
Sbjct: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1295

Query: 1290 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1349
            LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE
Sbjct: 1296 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1355

Query: 1350 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1409
            ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI
Sbjct: 1356 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1415

Query: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1469
            AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK
Sbjct: 1416 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1475

Query: 1470 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1529
            ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE
Sbjct: 1476 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1535

Query: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
            ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL
Sbjct: 1536 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1595

Query: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649
            DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV
Sbjct: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1655

Query: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1709
            QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN
Sbjct: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1715

Query: 1710 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769
            EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ
Sbjct: 1716 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1775

Query: 1770 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1829
            NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL
Sbjct: 1776 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1835

Query: 1830 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1889
            HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ
Sbjct: 1836 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1895

Query: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949
            KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK
Sbjct: 1896 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1955

Query: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2009
            QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ
Sbjct: 1956 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2015

Query: 2010 HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
            HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ+
Sbjct: 2016 HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 253/1217 (20%), Positives = 489/1217 (40%), Gaps = 168/1217 (13%)

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEY-----KE 428
            E ++ +V E+++L  DL+    +     S + D    ++  ++  LR+ +E        E
Sbjct: 909  EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASE 968

Query: 429  RIAALKNE-LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENEL 487
            ++A+ + E L  E +Q  Q+   + L +E  I KA T E   R+R  +S  E SRL++++
Sbjct: 969  QLASQRLERLEMEHDQERQEMMSKLLAMEN-IHKA-TCETADRERAEMST-EISRLQSKI 1025

Query: 488  LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS-----SAEFFLQE--ERLTQMRNEY 540
             E  +  +    L +  Q     V+ E+  + D +       E  L+E  + L  ++  +
Sbjct: 1026 KEMQQATSPLSMLQSGCQ-----VIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAH 1080

Query: 541  ERQCRV---LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEE 597
            E+  +    +  ++  LQ  L++    G V+   L + P+ E   N+   + E  L    
Sbjct: 1081 EQAVKENVKMATEISRLQQRLQKLEP-GLVMSSCL-DEPATEFFGNTAE-QTEPFLQQNR 1137

Query: 598  CNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 657
               +   +    V+  +++   RD+          V+  E +++E+  S +   E ++  
Sbjct: 1138 TKQVE-GVTRRHVLSDLEDDEVRDLGSTGTS---SVQRQEVKIEESEASVEGFSE-LENS 1192

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQE 717
             E  T + E     LKN+I++LQ Q  +L      A C    EKKQ    L  + + L++
Sbjct: 1193 EETRTESWE-----LKNQISQLQEQLMMLC-----ADCDRASEKKQ---DLLFDVSVLKK 1239

Query: 718  KLRLQHEM-ELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK 776
            KL++   + E   +         RE + LQ      E++R +    ++  +       E 
Sbjct: 1240 KLKMLERIPEASPKYKLLYEDVSRENDCLQ------EELRMMETRYDEALENNKELTAEV 1293

Query: 777  HTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK----VTERC--- 829
              L+ E  + E + +    L++  ++++ E N   + +  + Q   +K    V +RC   
Sbjct: 1294 FRLQDELKKMEEVTETFLSLEKSYDEVKIE-NEELNVLVLRLQGKIEKLQESVVQRCDCC 1352

Query: 830  --ESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLK-ETLKREKTT 886
              E++L++LE      +  L  Q  EE          + +EC +  + L+  T   EK  
Sbjct: 1353 LWEASLENLEIEPDGNILQLN-QTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEK-- 1409

Query: 887  SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ---QSLLSDQILELKSS 943
              V   E   L  T + H     V+ Q +L++   L    +     Q+ +++  LE    
Sbjct: 1410 --VKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467

Query: 944  HK--RELREREEVLCQAGASEQLASQRLERLEMEHD--------QERQEMM---SKLLAM 990
             +  R+L+ER  +L +         +  E   M HD        Q++ E++   S+ L  
Sbjct: 1468 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1527

Query: 991  EN-IHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
            EN I +    T + E +  + ++  L    +EM Q T  +    +  Q + E   +    
Sbjct: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587

Query: 1050 LSLLQQ-----GEQLLEENGDVLLSLQRAHE-------QAVKENVKMATEISRLQQRL-- 1095
            L +  Q       +L ++N      LQ  ++       Q  KE    A E  R Q++   
Sbjct: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE-EREQEKFNL 1646

Query: 1096 -QKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGVTRRHVLSDLED--D 1150
             ++LE   V SS L             QT    Q+N     ++E + + H   DL D   
Sbjct: 1647 KEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQ 1706

Query: 1151 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSE---LENSEETRTE---SWELKNQISQLQ 1204
            ++  + S     ++ +E   EE  + V+  ++   LE+   T  +   SWE  +Q + L+
Sbjct: 1707 KISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWE--HQSASLK 1764

Query: 1205 EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK-----YKLLY------- 1252
             QL+          +  Q++   +S +K  L++ ++  EA  +     +K L        
Sbjct: 1765 SQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1824

Query: 1253 --EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1310
              E  +  +    ++ R+   + D  +   ++L   +++  + L+ M + T+     E +
Sbjct: 1825 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQL---LWQENERLQTMVQNTKA----ELT 1877

Query: 1311 YDEVKIENEELNVLV-----LRLQGKIEKLQE---SVVQRCDCCLWEASLENLEIEPDGN 1362
            +   K+   E N+L      L   G +   ++   S+ + CD    E S  N ++    +
Sbjct: 1878 HSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNS 1937

Query: 1363 ILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNT-----------QLLEK-----VKA 1406
            + Q  +T+      ++     ++E   E Q+L               QLL++     V  
Sbjct: 1938 LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1997

Query: 1407 HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAE---------LELE 1457
             +   L   +    ER     Q  LE  T+       + +   T+ E         L+L 
Sbjct: 1998 EQFLQLQRQL-LQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV 2056

Query: 1458 KTKLQELTRKLKERVTI 1474
            K  LQE   +LKE+V++
Sbjct: 2057 KRLLQEKVNQLKEQVSL 2073


>gi|148536871 ninein isoform 1 [Homo sapiens]
          Length = 2046

 Score = 3962 bits (10276), Expect = 0.0
 Identities = 2026/2026 (100%), Positives = 2026/2026 (100%)

Query: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
            MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
Sbjct: 1    MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60

Query: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120
            RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
Sbjct: 61   RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF 120

Query: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180
            PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
Sbjct: 121  PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ 180

Query: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240
            DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
Sbjct: 181  DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE 240

Query: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300
            DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
Sbjct: 241  DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD 300

Query: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360
            GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
Sbjct: 301  GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA 360

Query: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420
            ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
Sbjct: 361  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420

Query: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480
            KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
Sbjct: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480

Query: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540
            SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
Sbjct: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540

Query: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
            ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
Sbjct: 541  ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600

Query: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
            LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
Sbjct: 601  LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660

Query: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
            ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
Sbjct: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720

Query: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780
            LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
Sbjct: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE 780

Query: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840
            KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY
Sbjct: 781  KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840

Query: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900
            RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
Sbjct: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960
            YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA
Sbjct: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960

Query: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020
            SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK
Sbjct: 961  SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1020

Query: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080
            EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
Sbjct: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080

Query: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140
            NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR
Sbjct: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140

Query: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200
            RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI
Sbjct: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200

Query: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260
            SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND
Sbjct: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260

Query: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
            CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE
Sbjct: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320

Query: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380
            LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV
Sbjct: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380

Query: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440
            HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF
Sbjct: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440

Query: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500
            QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI
Sbjct: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500

Query: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560
            TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET
Sbjct: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560

Query: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620
            VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ
Sbjct: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620

Query: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680
            KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK
Sbjct: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680

Query: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740
            DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI
Sbjct: 1681 DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740

Query: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800
            ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
Sbjct: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800

Query: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860
            QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ
Sbjct: 1801 QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ 1860

Query: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920
            TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS
Sbjct: 1861 TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS 1920

Query: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980
            PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
Sbjct: 1921 PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL 1980

Query: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ 2026
            LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ
Sbjct: 1981 LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ 2026



 Score =  145 bits (367), Expect = 3e-34
 Identities = 356/1718 (20%), Positives = 696/1718 (40%), Gaps = 328/1718 (19%)

Query: 442  EQILQQAGKQRLELEQEIEKA---KTEENYIRDRLALSLKENSRLENELLENAEKLAEYE 498
            E+IL    ++ +E  QEI KA     + N     L L+L EN  L  +   +   LA ++
Sbjct: 308  ERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLAL-ENELLVTKNSIHQAALASFK 366

Query: 499  NLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL 558
                 L   ++ V+ EK               E+L    ++ E+   ++  +VD+  + +
Sbjct: 367  AEIRHLLERVDQVVREK---------------EKLRSDLDKAEKLKSLMASEVDDHHAAI 411

Query: 559  EEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQH 618
            E  R     LR  L     E + A    +  E     ++     + +E E+   + +E +
Sbjct: 412  E--RRNEYNLR-KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENY 468

Query: 619  HRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE 678
             RD   L L+   ++ +      E + + +K  E     +EN T+ L++   +L+N +AE
Sbjct: 469  IRDRLALSLKENSRLEN------ELLENAEKLAE-----YENLTNKLQR---NLENVLAE 514

Query: 679  LQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASF 738
              G                  +    +  L+EE                  RLTQ +  +
Sbjct: 515  KFGDL----------------DPSSAEFFLQEE------------------RLTQMRNEY 540

Query: 739  EREREGLQSSAWTEEKVRGLTQELEQFH-QEQLTSLVEKHTLEKEELRKELLEKHQRELQ 797
            ER+   LQ      ++V  L  ELE++  Q ++  L  K++  +E      +E +   ++
Sbjct: 541  ERQCRVLQ------DQVDELQSELEEYRAQGRVLRLPLKNSPSEE------VEANSGGIE 588

Query: 798  EGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ 857
                    ECN     IEA             E  ++ ++ ++ +++  L+ +  ++   
Sbjct: 589  PEHGLGSEECNPLNMSIEA-------------ELVIEQMKEQHHRDICCLRLELEDKVRH 635

Query: 858  WEFEKDELTQECAEAQELLKE-------TLKRE----KTTSLVLTQEREMLEKTYKEHLN 906
            +E + DE    C +AQE +K+       TL+++    K     L  +  +L++ + E   
Sbjct: 636  YEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATC 695

Query: 907  SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA-SEQLA 965
                E++QL   LE+ +   + +  L  +  L+ + +  +   ERE    Q+ A +E+  
Sbjct: 696  RHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKV 755

Query: 966  SQRLERLEMEHDQERQEMMSK-LLAMENIHKATCETADRE----RAEMSTEISRLQSKIK 1020
                + LE  H ++   ++ K  L  E + K   E   RE    R +M TE +R  S+I+
Sbjct: 756  RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIE 815

Query: 1021 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080
                     +  QS CQ + E     + AL  L+         G     L+   EQ  +E
Sbjct: 816  ---------AQFQSDCQKVTER---CESALQSLE---------GRYRQELKDLQEQQREE 854

Query: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1140
              +   E   L Q   + +  L  +   ++  +       E  E   +++    V  V R
Sbjct: 855  KSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMV--VER 912

Query: 1141 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200
            + +L DLED  +R++  T  S +  Q ++++ S        EL   EE   ++   +   
Sbjct: 913  QQLLQDLED--LRNVSETQQSLLSDQILELKSSHKR-----ELREREEVLCQAGASEQLA 965

Query: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260
            SQ  E+L M         +++Q+++        KL  +E I      +K   E   RE  
Sbjct: 966  SQRLERLEM------EHDQERQEMM-------SKLLAMENI------HKATCETADRER- 1005

Query: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
                                 E++ E+ RLQ ++K+M++ T     L+     +  E  E
Sbjct: 1006 --------------------AEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045

Query: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1380
             +       G +  LQ+               E L  E    +L L +  E+ V     +
Sbjct: 1046 GD-------GALSLLQQG--------------EQLLEENGDVLLSLQRAHEQAVKENVKM 1084

Query: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440
               I   +Q  Q LE    +   +      +   T +        Q +  L++N T    
Sbjct: 1085 ATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE--------QTEPFLQQNRTK--- 1133

Query: 1441 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1500
            Q +    +  +++LE ++       R L    T  V++++V     K EE +A +     
Sbjct: 1134 QVEGVTRRHVLSDLEDDEV------RDLGSTGTSSVQRQEV-----KIEESEASVEGF-- 1180

Query: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560
              SE++         SE+ + E+  L+N+I+ L E+  +        +  ++++      
Sbjct: 1181 --SELEN--------SEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSV 1230

Query: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620
            +K++     KM+E + +   + K+  + +  EN  L       QE+L+ +  R  E L  
Sbjct: 1231 LKKK----LKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETRYDEALEN 1279

Query: 1621 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1680
             +         E   E F L++EL++ +  + T +S LE    EVKI+   +      L+
Sbjct: 1280 NK---------ELTAEVFRLQDELKKMEEVTETFLS-LEKSYDEVKIENEELNVLVLRLQ 1329

Query: 1681 DELEKMKQ--LHRCPDLSDFQQKISSV-LSYNEKLLKEKEALSEELNSCVDKLAKSSLLE 1737
             ++EK+++  + RC D   ++  + ++ +  +  +L+    L++ L  CV ++     + 
Sbjct: 1330 GKIEKLQESVVQRC-DCCLWEASLENLEIEPDGNILQ----LNQTLEECVPRVRS---VH 1381

Query: 1738 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKE 1797
            H I   KQE +  E  +  L+        ++  L  T+Q             R   Q + 
Sbjct: 1382 HVIEECKQENQYLEGNTQLLEK---VKAHEIAWLHGTIQT---------HQERPRVQNQV 1429

Query: 1798 ALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENE 1857
             L++    L  Q ++   ++   E+    + L    ++L  +++  L+ ++  L   E E
Sbjct: 1430 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK-ERVTILVKQKDVLSHGEKE 1488

Query: 1858 R-LQTMVQNTKAELTHSREKVRQL--ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1914
              L+ M+ + +   +  ++KV  L  ES  L                +QE   L+ E   
Sbjct: 1489 EELKAMMHDLQITCSEMQQKVELLRYESEKL----------------QQENSILRNEITT 1532

Query: 1915 FQKEQSPANRKVSQMNSLEQEL----ETIHLENEGLKKKQVKLDEQLMEMQ------HLR 1964
              +E S +N K+  +N  ++E+    ET+  EN  ++K    L +Q+ E++       L 
Sbjct: 1533 LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1592

Query: 1965 STA-TPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2023
            +T  +   S +   LQ L Q+   M+ +++       L + E+   +L+EELE    +++
Sbjct: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSS 1652

Query: 2024 TPQGNQEQLVTVMEERMIEVEQKLKLVKR---LLQEKVNQLKE-QLCKN-TKADAMVKDL 2078
            T       LV+ +E  + EV+ +  +V++   LL++++ ++K+   C + +     +  +
Sbjct: 1653 T-------LVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSV 1705

Query: 2079 YVENAQLLKALE-VTEQRQKTAEK--KNYLLEEKIASL 2113
               N +LLK  E ++E+     +K  K+ LLE +IA++
Sbjct: 1706 LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATM 1743


>gi|55749678 ninein-like [Homo sapiens]
          Length = 1382

 Score =  455 bits (1170), Expect = e-127
 Identities = 306/828 (36%), Positives = 470/828 (56%), Gaps = 55/828 (6%)

Query: 1   MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
           MDE E++ + ++L+E++ S DTTGTG L ++ELT LC  L LE+  PVL QTLL ++   
Sbjct: 1   MDE-EENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFA 59

Query: 61  RVHFDQFKEALILILS-----RTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQE 115
           RV+F++FKE  + +LS     R    +    E   S    PKYV G K YGRRS PE  +
Sbjct: 60  RVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCD 119

Query: 116 SVEEFPEVTVIEPLDEEARPSHI------------PAGDCSEHWKTQRSEEYEAEGQLRF 163
           +  E   V   E   + +  SH+             + + +E  K  ++E +EA+GQL+ 
Sbjct: 120 AATEARRVP--EQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQT 177

Query: 164 WNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEM 223
           W+ +D  + Q   SP  D  E +++ V E+LG+   GHL+ ++L  +C+  GLQ ++ E 
Sbjct: 178 WDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEE 237

Query: 224 LEEVFHNLDPDGT--MSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTT 281
           LE++F+ LD DG   +S+E+F  GLF +  +L   +ST  +  K     Q  +ESG  TT
Sbjct: 238 LEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTT 297

Query: 282 TSSAMTSTIG-FRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLT 340
           T+S++ S     R+FS +DDG G A  +++L  W +EGI+N +EIL++LDFS+D  +NL 
Sbjct: 298 TTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLL 357

Query: 341 ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM 400
           ELT AL+NEL+   +++ QAALA +  E+ +   +V+Q+ RE++K R DL++AEK     
Sbjct: 358 ELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEF 417

Query: 401 ASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIE 460
             E+DD H+ +E+  E  ++ L++ Y+ER++ L++E+  ERE   +QA +QR  LE ++ 
Sbjct: 418 VKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477

Query: 461 KAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 520
           + + EE  +R++L L+LKENSRL+ E++E  EKL++ E L  KLQ++LE VL +K   L+
Sbjct: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDK---LE 534

Query: 521 PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL-KNSPSEE 579
           P SAE   QEER   +  EYE +CR LQD+ DELQ+ELE     G   RLP  ++SPS  
Sbjct: 535 PQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELE-----GLWARLPKNRHSPSWS 589

Query: 580 VEANSGGIEPEHGLG----SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRH 635
            +     +    GLG    S   N   +SIE EL++EQ+KE H++D   LR +LE KV +
Sbjct: 590 PDGRRRQLP---GLGPAGISFLGNSAPVSIETELMMEQVKE-HYQD---LRTQLETKVNY 642

Query: 636 YEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATC 695
           YE+++     + +K +++M+Q    E   LE Q +DL+ E+ E   +     +   + T 
Sbjct: 643 YEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLE-ELHEKSQEVIWGLQEQLQDTA 701

Query: 696 RHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKV 755
           R  E +   Q+ L    T     L L+H   L+    +A+A    E  GL +        
Sbjct: 702 RGPEPE---QMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGAL----PAR 754

Query: 756 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKM 803
           R LT ELE+  Q  L     + +   E+L  E   K Q    E R +M
Sbjct: 755 RDLTLELEEPPQGPL----PRGSQRSEQLELERALKLQPCASEKRAQM 798



 Score =  126 bits (317), Expect = 2e-28
 Identities = 114/418 (27%), Positives = 201/418 (48%), Gaps = 68/418 (16%)

Query: 1727 VDKLAKSSLLEHRIATMKQEQKSWEHQSAS---------LKSQLVASQEKVQNLEDTVQN 1777
            V+   + SL  H    +   Q SW+ Q A+         L+ +    + K+ +LED V+ 
Sbjct: 1014 VEVARRGSLPSH--LQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA 1071

Query: 1778 VNLQMSRMKSD---LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1834
            +   +   ++D        +E   LK ++  + ++L+ A         +TH +    Q+K
Sbjct: 1072 LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAE--------STHDA----QRK 1119

Query: 1835 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNP 1894
             +       ++ ++++    E E L    QN K +L+    +V QL       HQ     
Sbjct: 1120 EIE------VLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA-STHQAQ--- 1169

Query: 1895 SGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLD 1954
                   E+ +++++      ++      ++  Q+  L  ELE ++ E++ L+    +L 
Sbjct: 1170 ------NEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223

Query: 1955 EQLMEMQHLRSTATPSPSPHAWDLQLLQQQA-----CPMVPREQFLQLQRQL-LQAERIN 2008
            + L E Q     A          L+L Q QA       +VP+++  +L R L LQ E+  
Sbjct: 1224 QTLEESQDQVQGA---------HLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQAR 1274

Query: 2009 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKN 2068
            + L  + E             E+ +   EER+ E E  LK ++ LLQEKV++LKEQ  KN
Sbjct: 1275 RRLDAQREEH-----------EKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKN 1323

Query: 2069 TKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVRNLTPAPLT 2126
            TK+D ++K+LYVENA L++AL+ TE++Q+ AEK++ LLEEK+ +L+ +V  + PA L+
Sbjct: 1324 TKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPAALS 1381



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 210/1058 (19%), Positives = 406/1058 (38%), Gaps = 148/1058 (13%)

Query: 531  ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
            ER  +   E+ ++       +++L  +  ++  QG   RL L  S   EVEA       E
Sbjct: 408  ERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRS---EVEA-------E 457

Query: 591  HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
              L  E+ +    ++E ++   Q +E   R+   L L+   ++   +K++ E V     +
Sbjct: 458  RELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRL---QKEIVEVVEKLSDS 514

Query: 651  QENMKQRHENETHTLEKQISDLKNEI-AELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
            +    +  ++    L+ ++     E+ A+ +  AAVLKE  +E  CR  +++        
Sbjct: 515  ERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKE--YELKCRDLQDRND------ 566

Query: 710  EEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ 769
                            EL+A L    A   + R    S +W+ +   G  ++L       
Sbjct: 567  ----------------ELQAELEGLWARLPKNRH---SPSWSPD---GRRRQLPGLGPAG 604

Query: 770  LTSLVEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 828
            ++ L     +  E EL  E +++H ++L   R ++ET+ N    +I A            
Sbjct: 605  ISFLGNSAPVSIETELMMEQVKEHYQDL---RTQLETKVNYYEREIAA------------ 649

Query: 829  CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 888
                   L+  + +E KD+++ +R E S  E +K +L +   ++QE++    ++ + T+ 
Sbjct: 650  -------LKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTAR 702

Query: 889  VLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS--LLSDQILELKSSHKR 946
                E+  L     + L  + +     LQ +   R  +E + S  L     L  +     
Sbjct: 703  GPEPEQMGLAPCCTQALCGLALRHHSHLQQI---RREAEAELSGELSGLGALPARRDLTL 759

Query: 947  ELREREEVLCQAGA--SEQLASQRLERLEMEHDQERQEM-MSKLLAMENIHKATCETADR 1003
            EL E  +     G+  SEQL  +R  +L+    ++R +M +S  L  E +  A  +  D 
Sbjct: 760  ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDG 819

Query: 1004 ERAEMSTEISRLQSKIKEM-QQATSPLSMLQSGCQVIGEEEVE----GDGALSLLQQGEQ 1058
               E   +       +    Q+ T  L  L+ GC   GE  +     GDG  S    G  
Sbjct: 820  PSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGC---GERPLAWLAPGDGRESEEAAGAG 876

Query: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR-------LQKLEPGLVMSSCLDEP 1111
                      + Q         +   +   SR+Q          ++ EP    ++ L++P
Sbjct: 877  PRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQP 936

Query: 1112 ATEFFG-----NTAEQTEPFLQQNRTKQVEGVT-RRHVLSDLEDDEVRDLGSTGTSSVQR 1165
                         A QT+P + +   +       +   L  ++++  R            
Sbjct: 937  GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASE 996

Query: 1166 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK----- 1220
            Q+ +   +E ++E      + E  R  S     Q++  Q       A  +    K     
Sbjct: 997  QQAR---AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053

Query: 1221 -KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETR 1272
             K D+   +  L+  ++ LE+  +     +L +  +S EN  L       ++EL   E+ 
Sbjct: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113

Query: 1273 YD------EALENNKELTA---EVFRLQDELKK--MEEVTETFLSLEKSYDEVKIENEEL 1321
            +D      E L+ +KE      EV   Q++  K  + ++    L L +     + +NEE 
Sbjct: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173

Query: 1322 NVLVLRLQGKIEKLQESVVQRCD-CCLWEASLENLEIEPDGNIL---QLNQTLEECVPRV 1377
             V +  L   +E++  S  Q+ D        LE L  E     L   +L QTLEE   +V
Sbjct: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQV 1233

Query: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1437
            +  H  + + + +      + Q +  V    +A LH  +    E+ R +     EE+   
Sbjct: 1234 QGAHLRLRQAQAQ------HLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQ 1287

Query: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
            L   ++  +    I  L+  +  LQE   KLKE+              EK  +   ++ +
Sbjct: 1288 LKATEERVEEAEMI--LKNMEMLLQEKVDKLKEQF-------------EKNTKSDLLLKE 1332

Query: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
            L +  + + + ++    +    ++++ +L  ++  LN+
Sbjct: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 81/385 (21%), Positives = 153/385 (39%), Gaps = 72/385 (18%)

Query: 381  REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKE 440
            REK+ + + L   E +   +   VD     +   +     +L EE       LKN+L + 
Sbjct: 1053 REKDDMETKLLHLEDVVRALEKHVD-----LRENDRLEFHRLSEEN----TLLKNDLGRV 1103

Query: 441  REQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENL 500
            R++ L+ A        +EIE  K ++      + +  ++N   +++L +   ++ +    
Sbjct: 1104 RQE-LEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQ---- 1158

Query: 501  TNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 560
                       L ++       + E  +  + LTQ   E  R  +   DQ+ +L+ ELE 
Sbjct: 1159 -----------LGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207

Query: 561  YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 620
               + + L+LP  +  ++ +E +   ++  H                 L + Q + QH +
Sbjct: 1208 LNQEHQSLQLPW-SELTQTLEESQDQVQGAH-----------------LRLRQAQAQHLQ 1249

Query: 621  DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD----LKNEI 676
            ++   RL  +D+V    + L       ++  +  ++ HE +    E+++ +    LKN  
Sbjct: 1250 EV---RLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNME 1306

Query: 677  AELQGQAAVLKEAHHEATCRHEEEKKQLQVK-LEEEKTHLQEKLRLQHEMELKARLTQAQ 735
              LQ +   LKE   + T      K  L +K L  E  HL   L               Q
Sbjct: 1307 MLLQEKVDKLKEQFEKNT------KSDLLLKELYVENAHLVRAL---------------Q 1345

Query: 736  ASFEREREGLQSSAWTEEKVRGLTQ 760
            A+ E++R   + S   EEKVR L +
Sbjct: 1346 ATEEKQRGAEKQSRLLEEKVRALNK 1370



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 94/440 (21%), Positives = 180/440 (40%), Gaps = 60/440 (13%)

Query: 693  ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA------QASFEREREGLQ 746
            A+CR + E+ Q    ++EE+     +   +   E +AR   A      + S E  R G  
Sbjct: 966  ASCRGQAERLQA---IQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSL 1022

Query: 747  SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
             S       +G  QE       QL +  E  T    E  K+ +E     L++    +E  
Sbjct: 1023 PSHLQLADPQGSWQE-------QLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKH 1075

Query: 807  CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 866
             + R +      + +  +++E   + L++  GR RQEL+  +     ++ + E  K +  
Sbjct: 1076 VDLREND-----RLEFHRLSEE-NTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKE 1129

Query: 867  QECAEAQEL------LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE 920
            + C+E + L       K+ L +     L L QE    +   +EH     V  Q L Q LE
Sbjct: 1130 KACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHR----VTIQMLTQSLE 1185

Query: 921  DLRNVSETQQSLLSDQILELK----------SSHKRELREREEVLCQAGASEQLASQRLE 970
            ++    + Q    SDQI +L+           S +    E  + L ++    Q A  RL 
Sbjct: 1186 EVVRSGQQQ----SDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLR 1241

Query: 971  RLEMEH-------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1023
            + + +H        Q+R   + +LL+++   +      D +R E   ++   + +++E +
Sbjct: 1242 QAQAQHLQEVRLVPQDRVAELHRLLSLQG--EQARRRLDAQREEHEKQLKATEERVEEAE 1299

Query: 1024 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ---AVKE 1080
                 + ML        +E+ E +    LL   ++L  EN  ++ +LQ   E+   A K+
Sbjct: 1300 MILKNMEMLLQEKVDKLKEQFEKNTKSDLLL--KELYVENAHLVRALQATEEKQRGAEKQ 1357

Query: 1081 NVKMATEISRLQQRLQKLEP 1100
            +  +  ++  L + + ++ P
Sbjct: 1358 SRLLEEKVRALNKLVSRIAP 1377



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 81/382 (21%), Positives = 161/382 (42%), Gaps = 75/382 (19%)

Query: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
            L   D     Q  +A  E  +TK+  L R+  +  T L+  +DV+   EK  +L+     
Sbjct: 1026 LQLADPQGSWQEQLAAPEEGETKIA-LEREKDDMETKLLHLEDVVRALEKHVDLR----- 1079

Query: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1557
                        E  R E  +L +EN++L+N++                           
Sbjct: 1080 ------------ENDRLEFHRLSEENTLLKNDLGR------------------------- 1102

Query: 1558 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1617
               V+QE  A +   +  +K+I  LK   ++   E   L+++N   +++L +LN R+ ++
Sbjct: 1103 ---VRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQL 1159

Query: 1618 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1677
                             QE    + + E  +V    L  SLE  +   + Q+  +Q+   
Sbjct: 1160 ----------------GQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK--- 1200

Query: 1678 LLKDELEKMKQLHRCPDL--SDFQQKI-SSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1734
             L+ ELE + Q H+   L  S+  Q +  S        L+ ++A ++ L   V  + +  
Sbjct: 1201 -LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQE-VRLVPQDR 1258

Query: 1735 LLE-HRIATMKQEQ--KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRV 1791
            + E HR+ +++ EQ  +  + Q    + QL A++E+V+  E  ++N+ + +      L+ 
Sbjct: 1259 VAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLK- 1317

Query: 1792 TQQEKEALKQEVMSLHKQLQNA 1813
             +Q ++  K +++     ++NA
Sbjct: 1318 -EQFEKNTKSDLLLKELYVENA 1338



 Score = 38.1 bits (87), Expect = 0.093
 Identities = 52/247 (21%), Positives = 108/247 (43%), Gaps = 25/247 (10%)

Query: 793  QRELQEGREKMET---ECNRRTSQIEAQFQSDCQKVTERCESALQSLE-GRYRQELKDLQ 848
            Q  +Q GRE +++     + + + +E  +  D + +T   +SA+Q      Y QEL    
Sbjct: 333  QEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMT--VDSAVQQAALACYHQELS--- 387

Query: 849  EQQREEKSQWEFEKDELTQECAEAQ----ELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
              Q+ +  Q   E+D+  Q+   A+    E +KE      T   +  ++ + LE+ Y+E 
Sbjct: 388  -YQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRER 446

Query: 905  L----NSMVVERQQLLQDLEDLRNVSE-------TQQSLLSDQILELKSSHKRELREREE 953
            L    + +  ER+   +     R   E        +++ L +++      + R  +E  E
Sbjct: 447  LSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVE 506

Query: 954  VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1013
            V+ +   SE+LA +  + LE     + +   ++LLA E    A  +  + +  ++     
Sbjct: 507  VVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRND 566

Query: 1014 RLQSKIK 1020
             LQ++++
Sbjct: 567  ELQAELE 573



 Score = 37.0 bits (84), Expect = 0.21
 Identities = 74/355 (20%), Positives = 137/355 (38%), Gaps = 33/355 (9%)

Query: 1563 QENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1622
            QE +  Q  VE L ++  + +   ++ +  N E  ++       L++L ++  + L Q  
Sbjct: 384  QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGY 443

Query: 1623 KEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDE 1682
            +E  +    E E E+    E+  R +      V  L+AE + ++ +  +  +EN  L+ E
Sbjct: 444  RERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKE 503

Query: 1683 L----EKMKQLHRCP-----DLS-----DFQQKISSVLSYNEK---LLKEKEALSEELNS 1725
            +    EK+    R       DL        + + + +L+  E+   +LKE E    +L  
Sbjct: 504  IVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQD 563

Query: 1726 CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV----ASQEKVQNLEDTVQNVNLQ 1781
              D+L     LE   A + + + S        + QL     A    + N         L 
Sbjct: 564  RNDELQAE--LEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELM 621

Query: 1782 MSRMKS---DLRVTQQEK-EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1837
            M ++K    DLR   + K    ++E+ +L +  +    K          S L  Q+    
Sbjct: 622  MEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKER-KDMEQARRREVSVLEGQKA--- 677

Query: 1838 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1892
               L+ L  + Q+++W   E+LQ   +  + E         Q    L  +H  HL
Sbjct: 678  --DLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHL 730



 Score = 35.8 bits (81), Expect = 0.46
 Identities = 65/340 (19%), Positives = 134/340 (39%), Gaps = 55/340 (16%)

Query: 957  QAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD-------------- 1002
            Q    EQLA+      ++  ++E+ +M +KLL +E++ +A  +  D              
Sbjct: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSE 1091

Query: 1003 ----------RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALS- 1051
                      R R E+    S   ++ KE++          S  +V+  +       LS 
Sbjct: 1092 ENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQ 1151

Query: 1052 ----LLQQGEQLL------EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE-- 1099
                +LQ G++        EE+   +  L ++ E+ V+   + + +I +L+  L+ L   
Sbjct: 1152 LNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQE 1211

Query: 1100 ------PGLVMSSCLDEPATEFFG---NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1150
                  P   ++  L+E   +  G      +     LQ+ R    + V   H L  L+ +
Sbjct: 1212 HQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGE 1271

Query: 1151 EVRDLGSTGTSSVQRQ----EVKIEESEASVEGFSE-LENSEETRTESWELKNQISQLQE 1205
            + R          ++Q    E ++EE+E  ++     L+   +   E +E   +   L +
Sbjct: 1272 QARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLK 1331

Query: 1206 QLMMLCADCDRA----SEKKQDLLFDVSVLKKKLKMLERI 1241
            +L +  A   RA     EK++       +L++K++ L ++
Sbjct: 1332 ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKL 1371



 Score = 35.8 bits (81), Expect = 0.46
 Identities = 50/220 (22%), Positives = 98/220 (44%), Gaps = 36/220 (16%)

Query: 356  SIHQAALASFKAEIRHLLERVDQVVR-------EKEKLRSDLD------------KAEKL 396
            S HQA     +  I+ L + +++VVR       + +KLR +L+             +E  
Sbjct: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223

Query: 397  KSLMAS--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 454
            ++L  S  +V   H  + +    +L+++    ++R+A L   L  + EQ  ++   QR E
Sbjct: 1224 QTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREE 1283

Query: 455  LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAE 514
             E++++   TEE      + L       +E  L E  +KL E      + ++N ++ L  
Sbjct: 1284 HEKQLK--ATEERVEEAEMIL-----KNMEMLLQEKVDKLKE------QFEKNTKSDLLL 1330

Query: 515  KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 554
            K  +L   +A      +   + +   E+Q R+L+++V  L
Sbjct: 1331 K--ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRAL 1368


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  213 bits (541), Expect = 2e-54
 Identities = 407/1958 (20%), Positives = 814/1958 (41%), Gaps = 288/1958 (14%)

Query: 351  LVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAA 410
            L ++  + +A L     E+  LL +  +   + EK+   L +  ++     +E+ +H A+
Sbjct: 270  LKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS 329

Query: 411  IERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQR-LELEQEIEKAKTEENYI 469
            + R  +     L +  K+    +   + +E + I Q +G +  LEL+  I    ++ +Y 
Sbjct: 330  LSRNAQEEKLSLQQVIKD----ITQVMVEEGDNIAQGSGHENSLELDSSI---FSQFDYQ 382

Query: 470  RDRLALSLKEN--SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF 527
                AL+L  +  +R    + +  ++LA  +   N LQ        ++    +       
Sbjct: 383  DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ--------QQHDQWEEEGKALR 434

Query: 528  LQEERLTQMRNEYERQCRVLQDQVDELQSE-------LEEYRAQGRVLRLPLKNSPSEEV 580
             + ++LT  R+    Q   LQ +VD L  E        EE R Q  VL           V
Sbjct: 435  QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494

Query: 581  EANSGGIEPEHGLGSEECNPLNMSI-------EAELVIEQMKEQHHRDICCLRLELEDKV 633
            E    G +   G   E+   L++++       E  + +E  + +   ++  LR  LE   
Sbjct: 495  ELQLQG-DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESS- 552

Query: 634  RHYEKQL-----DETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ-------- 680
             H E +L      E   +  +A++++ +   +E +TL+ +++DL+    +L         
Sbjct: 553  -HLEGELLRQEQTEVTAALARAEQSIAELSSSE-NTLKTEVADLRAAAVKLSALNEALAL 610

Query: 681  -----GQAAVLKEAHHEATCRH----EEEKKQLQVKLE----------EEKTHLQEKLRL 721
                  Q  +  E  +++ C      E+ +  LQV L           E+ THL+ +L+ 
Sbjct: 611  DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670

Query: 722  QHE--MELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ-------LTS 772
              E   EL+A L   Q   E  ++ L  S   +E     T +LEQ HQE          +
Sbjct: 671  AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE---AATTQLEQLHQEAKRQEEVLARA 727

Query: 773  LVEKHTLEKE----ELRKELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTE 827
            + EK  L +E    E+R + +E+ +++L E  + + +      +S  EAQ Q+   +VT+
Sbjct: 728  VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787

Query: 828  -RCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 883
             + E  +Q++   +   + E++ L+ +   E+SQ E E+D   ++ A+A++  K  L+++
Sbjct: 788  GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847

Query: 884  KTT-SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKS 942
            K      + Q RE  EK    H       +Q+L + LE L             + +EL+ 
Sbjct: 848  KAAHEKEVNQLREKWEKERSWH-------QQELAKALESLER-----------EKMELEM 889

Query: 943  SHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD 1002
              K +  E E +  Q       A   L ++++E ++ER  ++  LL  +       +  +
Sbjct: 890  RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949

Query: 1003 RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE-EEVEGDGALSLLQQGEQLLE 1061
            R R +M  +      K+KE +      + LQ   + + E      D   +L ++   LL+
Sbjct: 950  RLRQDMKVQ------KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003

Query: 1062 ENGDVLLSL-------------QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS--- 1105
            +  D+   +             QR  EQ V+E ++   E +R+Q+ L++ +  L +S   
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063

Query: 1106 -------------------SCLDEPATEFFGNTAE---QTEPFLQQNRTKQVEGVTRR-H 1142
                               S L +   E  G   E   Q E   Q+ + K+ + + +   
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123

Query: 1143 VLSDLEDDEVRD------LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWEL 1196
            +L +LE   + +      L +    + Q Q +++  +E+ +E  +  +          +L
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQLEALAAEQQPGNQAQAQAQL 1182

Query: 1197 KNQISQLQEQLMMLCADCDRAS------------EKKQDLLFDVSVLKKKLKMLERIPEA 1244
             +  S LQ+ L  +C      S            E  Q+    +      L  L     A
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 1245 SPKYKLLYEDV---SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL------- 1294
            S  +K L++D+    +  D L+++++ +E R  +      ++  E+  LQ +L       
Sbjct: 1243 SALHK-LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301

Query: 1295 -----------KKMEEVTETFLSLEKSYDEVKI-------ENEELNVLVLRLQGKIEKLQ 1336
                        ++ E+ ET  SL+      ++       E E L      L  ++E LQ
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361

Query: 1337 ESVVQRCDCCLWEASLENLEIEPDGNILQL-NQTLEECVPRVRSVHHVIEECKQENQYLE 1395
             +VV+          LE  ++    + L+L N+ +E    R +++    E    + + L+
Sbjct: 1362 AAVVEARAQASAAGILEE-DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420

Query: 1396 GNTQLLEKVKA---HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1452
             N  LL +  A    E+  L G IQ  +++  +Q   +   +  L     +    Q  I 
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
            ELE  ++ L+ L   ++ER   L  Q++ +   EK+ E +  + + Q+   E+++K +++
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL--ELEKKDQMI 1538

Query: 1513 RYESEKLQQ-ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ-ENAAVQK 1570
              +  ++Q  +  ++  E   L  E++   ++       Q+++ ++ E  ++ +  A+  
Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKME------CQQKLIKELEGQRETQRVALTH 1592

Query: 1571 MVENLKKQISELKIKNQQL-DLE--NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGN 1627
            +  +L+++  EL+ ++ Q+ DLE  +T L+++  +  ++++   +++ E+  Q++KE   
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL--QRQKEHLT 1650

Query: 1628 SALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKI-----------QTHIVQQE- 1675
              LE R+QE    KE ++  + Q +     LE +L ++K+           Q  ++Q+  
Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710

Query: 1676 ------NHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDK 1729
                  +   +  LE MK +     L D ++++     +  +L + K+ L ++L     K
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLI-----LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765

Query: 1730 LAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL 1789
            + ++SLL      + Q     E +   L+ QL  ++E+ +  E ++Q+   Q+   +  L
Sbjct: 1766 VGETSLL------LSQR----EQEIVVLQQQLQEAREQGELKEQSLQS---QLDEAQRAL 1812

Query: 1790 RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH-----L 1844
                QE EAL+QE      Q +    K+ A + A   +  H   K    +  DH      
Sbjct: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA--HMTLKERHGELQDHKEQARR 1870

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKH-----------LN 1893
            + EE  +  +  + L+ ++ + +AE     + +  L+     + Q+H           L 
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930

Query: 1894 PSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKL 1953
                +   +QE  +L+ E  Q  + Q  A R  ++  +L++ L   H   +G  K+Q  L
Sbjct: 1931 AQAVLKERDQELEALRAE-SQSSRHQEEAAR--ARAEALQEALGKAHAALQG--KEQHLL 1985

Query: 1954 DEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE 2013
            ++  +      STAT   S  A      Q +      R Q  ++Q Q L+ +   Q LQ+
Sbjct: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQEGEIQDQDLRYQEDVQQLQQ 2042

Query: 2014 ELENRTSETNTPQGNQEQLVTVMEERMIE--VEQKLKLVKRLLQEKVNQLKEQL--CKNT 2069
             L  R  E    Q  ++ L   + +R+ E  +++K  L +   +E++  L + +   + T
Sbjct: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLT 2102

Query: 2070 KADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLE 2107
             A    + L +   Q    LE      KT+  +   L+
Sbjct: 2103 LAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLK 2140



 Score =  202 bits (515), Expect = 2e-51
 Identities = 356/1733 (20%), Positives = 707/1733 (40%), Gaps = 269/1733 (15%)

Query: 347  ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 406
            E E LV + +  +  L + + + + L E++  +   KE L S L +A++  S++      
Sbjct: 730  EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789

Query: 407  HHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQ---AGKQRLELEQEIEKAK 463
                I+      + +  E  +  +  LK EL  ER Q  Q+   A +Q  + EQE + A 
Sbjct: 790  LEVQIQ-----TVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844

Query: 464  TEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSS 523
             ++    ++    L+E  + E E   + ++LA+      + +  LE  L E+  +++   
Sbjct: 845  EQQKAAHEKEVNQLRE--KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902

Query: 524  AEFFLQEER------LTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPS 577
            A+   +EER      L QM+ E E++   L + + + Q EL +   Q   LR  +K    
Sbjct: 903  AQ--REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960

Query: 578  EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCL----------RL 627
            +E E          G+   +        EA+  +++   QH  D+  L          ++
Sbjct: 961  KEQETT--------GILQTQLQ------EAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006

Query: 628  ELEDKVRHYEKQL----DETVVSCKKAQENMKQRHENET--HTLEKQISDLKNEIAELQG 681
            +L+ +V   + QL    D   +  ++ QE +++  E       LE++ + L   + E + 
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066

Query: 682  QAAVLKEA----HHEATCRHEE------EKKQLQVKLEEEKTHLQEKLR--LQHEMELKA 729
            +  VL+EA      E +   ++      E+K+L  ++E  +  ++EK    L  E +L  
Sbjct: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL-- 1124

Query: 730  RLTQAQASFEREREGLQSSAWTEE--------KVRGLTQELEQFHQEQ------------ 769
             L + +AS   E++ L++S W +E        ++R    +LE    EQ            
Sbjct: 1125 -LEELEASHITEQQ-LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182

Query: 770  --LTSLVEKHTLEKEELRKEL------------LEKHQRELQE-----------GREKME 804
              L S +++      E R EL            LE  Q   +              E + 
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 805  TECNR------RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQ---QREEK 855
            +  ++      +T Q     +   QK+ ER     ++ + +   EL+DLQ Q    +EEK
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDT-EAEKSQVHTELQDLQRQLSQNQEEK 1301

Query: 856  SQWEFEKDELTQECAEAQEL---LKETLKREKTTSLVLTQEREMLEKTYK------EHLN 906
            S+WE +++ L  E  E  E    L+  L+R +   +    ERE+L+   +      EHL 
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361

Query: 907  SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE--LREREEVLCQAGASEQL 964
            + VVE +        L     T +S L  +  E++S  +R   L+E+ E+    G + Q 
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421

Query: 965  ASQRLERLEMEHDQERQEMMSKLLAMEN---IHKATCETADRERAEMSTEISRLQSKIKE 1021
                L +   E ++E + +  ++  +E    + KA  E    +  + + E+   Q +I+E
Sbjct: 1422 NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481

Query: 1022 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1081
            +++  S L  L    Q       E +  L++ ++  + LE++ +   + +   E  + E 
Sbjct: 1482 LEKCRSVLEHLPMAVQ-------EREQKLTVQREQIRELEKDRE---TQRNVLEHQLLEL 1531

Query: 1082 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRR 1141
             K    I   + ++Q L+  LV   CL     E       Q +   +    ++ + V   
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591

Query: 1142 HVLSDLED---------DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTE 1192
            H+  DLE+          ++ DL S  T   +  + + +E ++  E   EL+  +E  T+
Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651

Query: 1193 SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1252
              E ++Q   LQ++ + +  D       +Q  + +  + + KL + ER  E + + +L+ 
Sbjct: 1652 DLERRDQELMLQKERIQVLED----QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQ 1707

Query: 1253 EDV------SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM-----EEVT 1301
            E        S+      E ++++    ++ +E  +E   E+  L+D+L++       +V 
Sbjct: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767

Query: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1361
            ET L L +   E+ +  ++L     R QG+++               E SL++   E   
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEA--REQGELK---------------EQSLQSQLDEAQR 1810

Query: 1362 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAH-EIAWLHGTIQTHQ 1420
             + Q +Q LE      +      E  K++   L+G  +     +AH  +   HG +Q H+
Sbjct: 1811 ALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE-----QAHMTLKERHGELQDHK 1865

Query: 1421 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKD 1480
            E+ R   + +  E   +   ++        + +L  E  + ++    L+++     ++ +
Sbjct: 1866 EQARRLEEELAVEGRRVQALEE-------VLGDLRAESREQEKALLALQQQCAEQAQEHE 1918

Query: 1481 VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSIS 1540
            V +   ++  L+A     Q    E  Q++E LR ES+  + +    R     L E    +
Sbjct: 1919 VETRALQDSWLQA-----QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973

Query: 1541 NLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN 1600
            +     L G ++ + ++ E  +   A+   +  +L    +  +   + L ++  E+  ++
Sbjct: 1974 H---AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQD 2030

Query: 1601 SQNQEKLQELNQRLT----EMLCQKEKEP------GNSALEEREQEKFNLKEELERCKVQ 1650
             + QE +Q+L Q L     E+  Q+E+E            E   QEK NL +E E  +++
Sbjct: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR 2090

Query: 1651 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE 1710
                 S  E +L+  + +  I++      ++ LE +   H+   + +   K+ S+     
Sbjct: 2091 GLHQ-SVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL---EP 2146

Query: 1711 KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQN 1770
            +L +E E L   L             E R    +++ +      A  K+ + + QE    
Sbjct: 2147 RLQRELERLQAALRQT----------EAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196

Query: 1771 LEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLHKQLQNAG------GKSWAPEI 1822
            L+ +V   + +  R++ +L +T++  EKE L     +   +L + G      G+    E 
Sbjct: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256

Query: 1823 ATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLES 1882
               P G+  Q  R    +L+HL     +L                           +++ 
Sbjct: 2257 EPSPDGMEKQSWR---QRLEHLQQAVARL---------------------------EIDR 2286

Query: 1883 NLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
            + L +H   L    T+   E+E+  LKRE  +  +  S    K +  +  +Q+
Sbjct: 2287 SRLQRHNVQLR--STLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337



 Score =  194 bits (493), Expect = 8e-49
 Identities = 369/1836 (20%), Positives = 761/1836 (41%), Gaps = 230/1836 (12%)

Query: 320  ENSQEILKALDF----SLDGNINLTELTLA--LENELLVTKNSIHQAALASFKAEIRHLL 373
            E  QE+L  L+     SL   I L E   +  LE ELL  + +   AALA  +  I  L 
Sbjct: 522  ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASE---VDDHHAAIERRNEYNLRKLD--EEYKE 428
               + +  E   LR+   K   L   +A +   ++     +E  N+    +++  E+ + 
Sbjct: 582  SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641

Query: 429  RIAALKNELRKEREQI----------LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLK 478
             +     E  K RE +          LQ+A +   EL+ ++   + E+  I+ +L+ S  
Sbjct: 642  ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701

Query: 479  ENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN 538
            +      +L +  ++    E +  +  +  E ++ EK        A   ++ + + + R 
Sbjct: 702  QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK--------AALEVRLQAVERDRQ 753

Query: 539  EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 598
            +   Q + L    + L+S L E + Q  V+ +        EV+  +     E   G   C
Sbjct: 754  DLAEQLQGLSSAKELLESSLFEAQQQNSVIEV---TKGQLEVQIQTVTQAKEVIQGEVRC 810

Query: 599  NPLNMSIEAELVIEQMKEQHHRDICCLRLE----LEDKVRHYEKQLDETVVSCKKAQENM 654
              L +  E     EQ ++   R +     E    LE +   +EK++++     +K +   
Sbjct: 811  LKLELDTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869

Query: 655  KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 714
            +Q       +LE++  +L+  + E Q +   ++    E   + E    Q+Q++ E+E+  
Sbjct: 870  QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929

Query: 715  LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 774
            L E L     ++ +  L  A    ER R+ ++     E++  G+ Q   Q  Q +L    
Sbjct: 930  LLETL-----LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984

Query: 775  EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 834
             +H   +++L    L++    L + +  ++ +     SQ+ A  Q D Q++ E+      
Sbjct: 985  RQH---RDDL--AALQEESSSLLQDKMDLQKQVEDLKSQLVA--QDDSQRLVEQ------ 1031

Query: 835  SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 894
                  +++L++ QE  R +K + E EK  LT    E ++ L   L  ++  S+     R
Sbjct: 1032 ----EVQEKLRETQEYNRIQK-ELEREKASLTLSLMEKEQRL---LVLQEADSI-----R 1078

Query: 895  EMLEKTYKEHLNSMVVERQQLLQDLEDLR-NVSETQQSLLSDQ---ILELKSSHKRELRE 950
            +      ++ +     E+++L   +E LR  V E +   L+ +   + EL++SH  E + 
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R  +  Q   + QL      +L +   + + E ++      N  +A        +A++++
Sbjct: 1139 RASLWAQEAKAAQL------QLRLRSTESQLEALAAEQQPGNQAQA--------QAQLAS 1184

Query: 1011 EISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLS- 1069
              S LQ  +  + ++   LS        +   E + +GA SL ++G  L   + + + S 
Sbjct: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244

Query: 1070 LQRAHEQAVKENVKMATEISR--LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFL 1127
            L + H+   K      T+ +R  L+ ++QKLE  L      D  A +   +T  Q    L
Sbjct: 1245 LHKLHQDLWK------TQQTRDVLRDQVQKLEERLT-----DTEAEKSQVHTELQD---L 1290

Query: 1128 QQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1187
            Q+  ++  E  ++     +  + E+ +L  T  +S+Q +  + E      +G  EL  + 
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHET-MASLQSRLRRAELQRMEAQGERELLQAA 1349

Query: 1188 ETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK 1247
            +       L  Q+  LQ  ++   A    A   ++DL    S LK K + +E   E +  
Sbjct: 1350 KE-----NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404

Query: 1248 YKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETF-LS 1306
             +   E    +   LQE L ++     E  E  + L  ++  L+ + +  +   E   L 
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464

Query: 1307 LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQL 1366
            L+K   EV ++ E++  L  + +  +E L  +V +R          + L ++ +    Q+
Sbjct: 1465 LKKRNQEVDLQQEQIQELE-KCRSVLEHLPMAVQER---------EQKLTVQRE----QI 1510

Query: 1367 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ 1426
             +  ++   +   + H + E ++++Q +E     ++ +K   +      ++         
Sbjct: 1511 RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE--------- 1561

Query: 1427 NQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK----DVL 1482
                LEEN   +  Q K  +      + E ++  L  LT  L+ER   L  Q     D+ 
Sbjct: 1562 ----LEENHHKMECQQKLIKELE--GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLE 1615

Query: 1483 SHG--------EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLN 1534
            SH         E+++E+K+    ++    E+Q++ E L  + E+  QE  + +  I  L 
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIE----ELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671

Query: 1535 E---------EDSISNLKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1579
            +         E+ +  +KL        L   ++ M ++ E  K  + A +  +E++K   
Sbjct: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK--- 1728

Query: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA--LEEREQEK 1637
              L +++++ ++E  +      ++  +LQEL  +L + L    ++ G ++  L +REQE 
Sbjct: 1729 --LILRDKEKEVECQQ------EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-QLHRCPDLS 1696
              L+++L+  + Q      SL+++L E +       QE   L+ E ++ + Q  R  + +
Sbjct: 1781 VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKA 1840

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE-HRIATMKQEQKSWEHQSA 1755
            D    +   L      LKE+    ++      +L +   +E  R+  +++       +S 
Sbjct: 1841 D---ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897

Query: 1756 SLKSQLVASQEKV--QNLEDTVQNVNLQMSRMKSD--LRVTQQEKEALKQEVMSLHKQ-- 1809
              +  L+A Q++   Q  E  V+   LQ S +++   L+   QE EAL+ E  S   Q  
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE 1957

Query: 1810 --------LQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQT 1861
                    LQ A GK+ A         L   +   S +     +          + +L+ 
Sbjct: 1958 AARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE 2017

Query: 1862 MVQNTKAELTHS----REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQK 1917
             ++  + E+       +E V+QL+  L  + ++        +  E+E+L  K    + Q+
Sbjct: 2018 ALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE------LRHQQEREQLLEKSLAQRVQE 2071

Query: 1918 EQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWD 1977
                  + + Q    E+E+  +H     L+    + +++++E++  +        PH+  
Sbjct: 2072 NMIQEKQNLGQERE-EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130

Query: 1978 LQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENR---------TSETNTPQGN 2028
               +++Q+  +   E  LQ + + LQA  + Q    E+E R          ++T     +
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQA-ALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189

Query: 2029 QEQLVTVMEERMIE-------VEQKLKLVKRLLQEK 2057
             +++   ++  ++E       ++ +L+L +R L+++
Sbjct: 2190 LQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225



 Score =  189 bits (479), Expect = 3e-47
 Identities = 399/1919 (20%), Positives = 778/1919 (40%), Gaps = 291/1919 (15%)

Query: 338  NLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLK 397
            NL EL + LE E    ++      LA    ++R  +E+ D V    + LR D++K     
Sbjct: 95   NLDELLVRLEEEQQRCES------LAEVNTQLRLHMEKADVV---NKALREDVEKLTVDW 145

Query: 398  SLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQ 457
            S    E+    +  +   E+    L  E+   ++  +  +   R  +  ++   R  +E 
Sbjct: 146  SRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMEL 205

Query: 458  EIEKAKTEENYIRDRLALSLKENSRLEN-----------ELLENAEKLAEYENLTNKLQR 506
            + E  +   + +   L L++   SR  N           +LL    K  E E   +  +R
Sbjct: 206  KAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAH--ER 263

Query: 507  NLENVLAEKFGDLDPSSAEFFLQE--ERLTQMRNE---YERQCRVLQDQVDELQS---EL 558
            + E +  +  GDL+ +  +  + E    LTQ + +   YE+  + L++ V+ L++   EL
Sbjct: 264  SQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTEL 323

Query: 559  EEYRA--------QGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELV 610
             E+ A        +   L+  +K+     VE    G     G G E    L+ SI     
Sbjct: 324  MEHEASLSRNAQEEKLSLQQVIKDITQVMVEE---GDNIAQGSGHENSLELDSSI----- 375

Query: 611  IEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRH---ENETHTLEK 667
              Q   Q       L   +  + R   + L + +  C++A   ++Q+H   E E   L +
Sbjct: 376  FSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQ 435

Query: 668  QISDLKNE-------IAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
            ++  L  E         +LQG+   L +         EE ++QL+V LE+E   L+   R
Sbjct: 436  RLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV-LEQEAWRLR---R 491

Query: 721  LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE-KHTL 779
            +  E++L+    Q Q   E ++E L  +    E+++ +   LE    E L+ L+  +  L
Sbjct: 492  VNVELQLQGDSAQGQK--EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREAL 549

Query: 780  EKEELRKELLEKHQRELQEGREKMETECNRRTSQIE------AQFQSDCQKVTERCESAL 833
            E   L  ELL + Q E+     + E      +S         A  ++   K++   E+  
Sbjct: 550  ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALA 609

Query: 834  QSLEGRYRQELKDLQEQQREEKSQWEFE---KDELTQECAEAQELLKETLKREKTTSLVL 890
                G   Q+L  L+E+ +   S+ E     ++ L  + AEA++  +E L  + T     
Sbjct: 610  LDKVG-LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR-REALWEKNTHLEAQ 667

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
             Q+ E      +  L  +  E++++ + L + R+    QQ   + Q+ +L    KR+   
Sbjct: 668  LQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH----QQEAATTQLEQLHQEAKRQ--- 720

Query: 951  REEVLCQAGASEQLASQRLERLEMEH---DQERQEMMSKLLAMENIHKATCETADRERAE 1007
             EEVL +A   ++   +    LE+     +++RQ++  +L  + +  K   E++  E  +
Sbjct: 721  -EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSA-KELLESSLFEAQQ 778

Query: 1008 MSTEISRLQSKIK-EMQQATSPLSMLQSGCQVI--------GEEEVEGDGALSLLQQGEQ 1058
             ++ I   + +++ ++Q  T    ++Q   + +         + E E D A   L Q EQ
Sbjct: 779  QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838

Query: 1059 LLEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSC-----LDEPA 1112
               E    L   + AHE+ V +   K   E S  QQ L K    L          L E  
Sbjct: 839  ---EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ 895

Query: 1113 TEFFGNTAEQTEPFLQ-QNRTKQVEGVTRRHVLS------------------------DL 1147
            TE     A++ E   Q ++   Q++  T +  +S                        D+
Sbjct: 896  TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955

Query: 1148 EDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSEL----ENSEETRTESWELKNQISQL 1203
            +  ++++  +TG    Q QE + E  EA+ +   +L    E S     +  +L+ Q+  L
Sbjct: 956  KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDL 1015

Query: 1204 QEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED----VSREN 1259
            + QL+          ++ Q+ L +     +  K LER  +AS    L+ ++    V +E 
Sbjct: 1016 KSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER-EKASLTLSLMEKEQRLLVLQEA 1074

Query: 1260 DCL-QEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE----KSYDEV 1314
            D + Q+EL  +     EA    KEL+A++  L+ E+K+ E     FL+ E    +  +  
Sbjct: 1075 DSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEA---DFLAQEAQLLEELEAS 1131

Query: 1315 KIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPD-GNILQLNQTLEEC 1373
             I  ++L   +   + K  +LQ  +         E+ LE L  E   GN  Q    L   
Sbjct: 1132 HITEQQLRASLWAQEAKAAQLQLRLRST------ESQLEALAAEQQPGNQAQAQAQLASL 1185

Query: 1374 VPRVRSVHHVIEECKQENQYLEGN---------------------------TQLLEKVKA 1406
               ++     + E + E   L G                            T L  +  A
Sbjct: 1186 YSALQQALGSVCESRPE---LSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 1407 HEIAWLHGTI-QTHQERPRVQNQVI-LEENTTLLGFQDKHFQHQATIAELELEKTKLQEL 1464
              +  LH  + +T Q R  +++QV  LEE  T             T AE     T+LQ+L
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLT------------DTEAEKSQVHTELQDL 1290

Query: 1465 TRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENS 1524
             R+L +       Q++      K+  L++ + +L  T + +Q ++     +  + Q E  
Sbjct: 1291 QRQLSQN------QEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344

Query: 1525 ILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKI 1584
            +L+     L  +               E +       + + +A   + E+L+   S LK+
Sbjct: 1345 LLQAAKENLTAQ--------------VEHLQAAVVEARAQASAAGILEEDLRTARSALKL 1390

Query: 1585 KNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL 1644
            KN++++ E         Q + K+ +  + L E L    +      L ERE+E   L+ ++
Sbjct: 1391 KNEEVESERERAQALQEQGELKVAQ-GKALQENLALLTQ-----TLAEREEEVETLRGQI 1444

Query: 1645 ERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISS 1704
            +  + Q     ++LE    ++K       + N  +  + E++++L +C  +   +    +
Sbjct: 1445 QELEKQREMQKAALELLSLDLK-------KRNQEVDLQQEQIQELEKCRSV--LEHLPMA 1495

Query: 1705 VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSAS---LKSQL 1761
            V    +KL  ++E + E      D+  + ++LEH++  ++++ +  E Q      LK QL
Sbjct: 1496 VQEREQKLTVQREQIRELEK---DRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552

Query: 1762 VASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPE 1821
            V  +     LE+    +  Q   +K      + ++ AL    + L ++ Q         E
Sbjct: 1553 VTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ---------E 1603

Query: 1822 IATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLE 1881
            +    S +H+                    L   +  L   +Q    E+   RE++ +L+
Sbjct: 1604 LQAQSSQIHD--------------------LESHSTVLARELQERDQEVKSQREQIEELQ 1643

Query: 1882 SNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHL 1941
                 + ++HL     +   +QE L L++E  Q  ++Q     K+     LE++LE I L
Sbjct: 1644 -----RQKEHLTQD--LERRDQE-LMLQKERIQVLEDQRTRQTKI-----LEEDLEQIKL 1690

Query: 1942 ENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQL 2001
                L+++  +L  Q   MQ     A     P       L+     +  +E+ ++ Q++ 
Sbjct: 1691 S---LRERGRELTTQRQLMQE---RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH 1744

Query: 2002 L-QAERINQHLQEELEN---RTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEK 2057
            + + + +   L+++L+    +  ET+     +EQ + V+++++ E  ++ +L ++ LQ +
Sbjct: 1745 IHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQ 1804

Query: 2058 VNQLKEQLC-KNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSN 2115
            +++ +  L  ++ + +A+ ++      Q  +  E  +  Q   E+ +  L+E+   L +
Sbjct: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQD 1863



 Score =  139 bits (351), Expect = 2e-32
 Identities = 327/1562 (20%), Positives = 642/1562 (41%), Gaps = 257/1562 (16%)

Query: 307  VERILDTWQEEGIENSQEILKALDF----SLDGNINLTE-------LTLALENELLVTKN 355
            V ++ + W++E   + QE+ KAL+      ++  + L E       +    E E    ++
Sbjct: 855  VNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914

Query: 356  SIHQAALASFKAEIRHLLERVDQVVRE-------KEKLRSDLDKAEKLK-----SLMASE 403
            ++ Q  L + K  +  LLE + Q  +E        E+LR D+ K +KLK      ++ ++
Sbjct: 915  ALCQMQLETEKERV-SLLETLLQTQKELADASQQLERLRQDM-KVQKLKEQETTGILQTQ 972

Query: 404  VDDHHAAIE---RRNEYNLRKLDEEYKERI---AALKNELRKEREQILQQAGKQRLELEQ 457
            + +    ++   R++  +L  L EE    +     L+ ++   + Q++ Q   QRL +EQ
Sbjct: 973  LQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL-VEQ 1031

Query: 458  EI-EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENV---LA 513
            E+ EK +  + Y R +  L  +E + L   L+E  ++L   +   +  Q+ L  +   + 
Sbjct: 1032 EVQEKLRETQEYNRIQKELE-REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQ 1090

Query: 514  EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD-------ELQSELEEYRAQGR 566
            E  G+    SA+  L  + + +   ++  Q   L ++++       +L++ L    A+  
Sbjct: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA 1150

Query: 567  VLRLPLKNS------------PSEEVEANS------------------------------ 584
             L+L L+++            P  + +A +                              
Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA 1210

Query: 585  ---GGIEPEHGLGSE--ECNPLNMSIEAELVIEQM--------KEQHHRDICCLRLELED 631
                G+EP+        +  PL  ++ AE V   +        K Q  RD+      L D
Sbjct: 1211 PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV------LRD 1264

Query: 632  KVRHYEKQLDETVVSCKKAQ---------------ENMKQRHENETHTLEKQISDLKNEI 676
            +V+  E++L +T    +K+Q               +  K + E + ++LE ++ +L   +
Sbjct: 1265 QVQKLEERLTDT--EAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322

Query: 677  A--------------ELQGQAAVLKEAHHEATCRHE-------EEKKQLQVK--LEEEKT 713
            A              E QG+  +L+ A    T + E       E + Q      LEE+  
Sbjct: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLR 1382

Query: 714  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 773
              +  L+L++E E+++   +AQA  E+    +      +E +  LTQ L +  +E  T  
Sbjct: 1383 TARSALKLKNE-EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441

Query: 774  VEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESA 832
             +   LEK+ E++K  LE    +L++  ++++ +      Q + Q    C+ V E    A
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ------QEQIQELEKCRSVLEHLPMA 1495

Query: 833  LQSLEGR---YRQELKDLQEQQREEKSQWEFEKDELTQ--ECAEAQELLKETLKREKTTS 887
            +Q  E +    R+++++L++ +  +++  E +  EL +  +  E+Q    + LK++  T 
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL 1555

Query: 888  LVLTQE-------REMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILEL 940
              L  E        E  +K  KE       +R  L     DL   S+  Q+  S QI +L
Sbjct: 1556 ECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA-QSSQIHDL 1614

Query: 941  KSSH---KRELRER-EEVLCQAGASEQLASQRLERLEMEHDQERQEMM------------ 984
            +S      REL+ER +EV  Q    E+L  Q+ E L  + ++  QE+M            
Sbjct: 1615 ESHSTVLARELQERDQEVKSQREQIEELQRQK-EHLTQDLERRDQELMLQKERIQVLEDQ 1673

Query: 985  ----SKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ-QATSPLSMLQSGCQVI 1039
                +K+L  E++ +      +R R E++T+   +Q + +E +  + +    L+    ++
Sbjct: 1674 RTRQTKILE-EDLEQIKLSLRERGR-ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731

Query: 1040 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL- 1098
             ++E E +     + + ++L ++    L  L R   +      +   EI  LQQ+LQ+  
Sbjct: 1732 RDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAR 1791

Query: 1099 EPGLVMSSCLDEPATEFFGNTAEQTEPF--LQQNRTKQVEGVTRR------HVLSDLEDD 1150
            E G +    L     E     A++ +    LQQ + +Q +G   R       +   LE  
Sbjct: 1792 EQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQ-QQAQGQEERVKEKADALQGALEQA 1850

Query: 1151 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEET----RTESWELKNQISQLQEQ 1206
             +      G     +++ +  E E +VEG   ++  EE     R ES E +  +  LQ+Q
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEG-RRVQALEEVLGDLRAESREQEKALLALQQQ 1909

Query: 1207 LMMLCADCDRASEKKQDLLFD-----VSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
                CA+  +  E +   L D      +VLK++ + LE +   S   +   E      + 
Sbjct: 1910 ----CAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA 1965

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSY-----DEVKI 1316
            LQE L     +   AL+  ++   E   L   L+      +  L   +++     + ++I
Sbjct: 1966 LQEAL----GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021

Query: 1317 ENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLE-----NLEIEPDGNILQLNQTL- 1370
            +  E+    LR Q  +++LQ+++ QR +    +   E     +L      N++Q  Q L 
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLG 2081

Query: 1371 -EECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH--QERPRVQN 1427
             E     +R +H  + E            QL    K  EI  L  T Q +  +  P    
Sbjct: 2082 QEREEEEIRGLHQSVRE-----------LQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130

Query: 1428 QVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKER---VTILVKQKDVLSH 1484
               +EE +  L   +   Q +    +  L +T+ +E+  + K +   +++   +  V S 
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190

Query: 1485 GEKEEELKAMMHDLQITCSEMQQKVELLR--YESEKLQQENSILRNEITTLNEEDSISNL 1542
             E    L+A + +       +Q ++EL R   E E+L    +    E+ +  E+     +
Sbjct: 2191 QEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQ----GV 2246

Query: 1543 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1602
            +LG ++G + E          E  + ++ +E+L++ ++ L+I   +L   N +L     Q
Sbjct: 2247 QLGEVSGVEAE----PSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302

Query: 1603 NQEKLQELNQRLTEMLCQKEKEPGN-SALEEREQEKFNLKEELERCKVQSSTLVSSLEAE 1661
             + + ++L +           E    +A    +Q+    K    +C  +    V  L+A+
Sbjct: 2303 VERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQ 2362

Query: 1662 LS 1663
            L+
Sbjct: 2363 LT 2364



 Score =  134 bits (338), Expect = 7e-31
 Identities = 287/1449 (19%), Positives = 569/1449 (39%), Gaps = 191/1449 (13%)

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECN--RRTSQIEAQFQ 819
            L     + L  ++E+  L  ++   E      R+L+  +E  + +    R+      Q++
Sbjct: 8    LNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYR 67

Query: 820  SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET 879
            S CQ++ +R    L++  G   Q  ++++E   +E      E+ +  +  AE    L+  
Sbjct: 68   SWCQELEKR----LEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLH 123

Query: 880  LKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD---- 935
            +++    +  L ++ E L   +    + ++ +  Q   + E  +   + +   L      
Sbjct: 124  MEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWRE 183

Query: 936  ------QILELKSSHKRELREREEVLCQAGASEQLASQRLE-RLEMEHDQERQEMMSKLL 988
                    LE+KS+  R+L E +    +   S      RL    +         M  +  
Sbjct: 184  VVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREP 243

Query: 989  AMENIHKATCETADRERAEMSTEISRLQSK----IKEMQQATSPLSMLQSGCQVIGEEEV 1044
            A   +  A  +  ++E  E S E+ +L+S+      E+Q   + LS L +  Q   E+  
Sbjct: 244  AQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDY- 302

Query: 1045 EGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVM 1104
              +  +  L++  ++LE N   L+     HE ++  N +   E   LQQ ++ +   +V 
Sbjct: 303  --EKMIKALRETVEILETNHTELME----HEASLSRNAQ--EEKLSLQQVIKDITQVMV- 353

Query: 1105 SSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQ 1164
                 E        +  +    L  +            + S  +  +     +   S + 
Sbjct: 354  -----EEGDNIAQGSGHENSLELDSS------------IFSQFDYQDADKALTLVRSVLT 396

Query: 1165 RQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDL 1224
            R+   +++    + G  E  N  + + + WE + +   L+++L  L  + D  + +  DL
Sbjct: 397  RRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKA--LRQRLQKLTGERDTLAGQTVDL 454

Query: 1225 LFDVSVLKKKLKMLERIPEASPKYKLLYEDVS---------------------------- 1256
              +V  L K+ ++L++  E   +   + E  +                            
Sbjct: 455  QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL 514

Query: 1257 ----RENDCLQEELRMMETRYDEALENNKEL--TAEVFRLQDELKKME--EVTETFLSLE 1308
                RE + LQE L  +E +  E+L     L    E   L+ EL + E  EVT      E
Sbjct: 515  HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAE 574

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQ 1368
            +S  E+      L   V  L+    KL              A  E L ++  G    LNQ
Sbjct: 575  QSIAELSSSENTLKTEVADLRAAAVKLS-------------ALNEALALDKVG----LNQ 617

Query: 1369 TLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQ 1428
             L +     +SV   +E  +Q    L+    L E  K  E  W   T    Q +   +  
Sbjct: 618  QLLQLEEENQSVCSRMEAAEQARNALQ--VDLAEAEKRREALWEKNTHLEAQLQKAEEAG 675

Query: 1429 VILEENTTLLGFQDKHFQHQATIAEL----ELEKTKLQELTRKLKERVTIL---VKQKDV 1481
              L+ +  L   Q++  + Q  ++E     E   T+L++L ++ K +  +L   V++K+ 
Sbjct: 676  AELQAD--LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEA 733

Query: 1482 LSHGEK--EEELKAMMHDLQITCSEMQ---QKVELLRYESEKLQQENSI-------LRNE 1529
            L   +   E  L+A+  D Q    ++Q      ELL     + QQ+NS+       L  +
Sbjct: 734  LVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793

Query: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
            I T+ +   +   ++  L    +   ++++  ++ +AA +++ +  ++  + L+ +    
Sbjct: 794  IQTVTQAKEVIQGEVRCLKLELDT--ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH 851

Query: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEER--EQEKFNLKEELERC 1647
            + E  +L +K  + +   Q+   +  E L ++EK      L+E+  E E    + E ER 
Sbjct: 852  EKEVNQLREKWEKERSWHQQELAKALESL-EREKMELEMRLKEQQTEMEAIQAQREEERT 910

Query: 1648 KVQSSTLVSSLEAELSEVKIQTHIVQQENHLL--KDELEKMKQLHRCPDLSDFQQKISSV 1705
            + +S+     LE E   V +   ++Q +  L     +LE+++Q  +   L +  Q+ + +
Sbjct: 911  QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE--QETTGI 968

Query: 1706 LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQ 1765
            L    +L + +  L E      D LA    L+   +++ Q++   + Q   LKSQLVA  
Sbjct: 969  LQ--TQLQEAQRELKEAARQHRDDLAA---LQEESSSLLQDKMDLQKQVEDLKSQLVAQD 1023

Query: 1766 EKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATH 1825
            +  + +E  VQ       +++      + +KE L++E  SL   L               
Sbjct: 1024 DSQRLVEQEVQE------KLRETQEYNRIQKE-LEREKASLTLSL--------------- 1061

Query: 1826 PSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLL 1885
               +  +Q+ L   + D +  +E   L Q+ +  Q   +   A++   R++V++ E++ L
Sbjct: 1062 ---MEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFL 1118

Query: 1886 PKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEG 1945
             +  + L      + TEQ+  +          +++ A +   ++ S E +LE +  E + 
Sbjct: 1119 AQEAQLLEELEASHITEQQLRA------SLWAQEAKAAQLQLRLRSTESQLEALAAEQQ- 1171

Query: 1946 LKKKQVKLDEQLMEM-----QHLRSTATPSP--------SPHAWDLQLLQQQACPMVPRE 1992
                Q +   QL  +     Q L S     P        +P  W L+  Q  A  +  R 
Sbjct: 1172 -PGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRG 1230

Query: 1993 QFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKR 2052
              L      L AE +   L +  ++      T    ++Q V  +EER+ + E +   V  
Sbjct: 1231 PLLTA----LSAEAVASALHKLHQDLWKTQQTRDVLRDQ-VQKLEERLTDTEAEKSQVHT 1285

Query: 2053 LLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIAS 2112
             LQ+   QL +   + +K +     L  E  +L + +   + R + AE +    + +   
Sbjct: 1286 ELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL 1345

Query: 2113 LSNIVRNLT 2121
            L     NLT
Sbjct: 1346 LQAAKENLT 1354


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  213 bits (541), Expect = 2e-54
 Identities = 405/1976 (20%), Positives = 830/1976 (42%), Gaps = 311/1976 (15%)

Query: 345  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 404
            +L  E L+ +    + +L+S++ +   L+     + REK+KL+  L +++       +E+
Sbjct: 133  SLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL 192

Query: 405  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEK 461
             +     ++  ++   + D   EE  + I+ L+ ++   ++++  + G   +++ + + +
Sbjct: 193  REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL--RNGPMNVDVLKPLPQ 250

Query: 462  AKTEENYIRDRLALSLKENSRLENE-LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 520
             + +          + +EN   + E ++E+   +   E L  +++R  EN+L      + 
Sbjct: 251  LEPQAE------VFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQ-ENLLKRCKETIQ 303

Query: 521  PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR----AQGRVLRLPLKNSP 576
                     +E+ T + +E E     LQ+Q+DE   ELE+ +    A+   L   L+++ 
Sbjct: 304  S-------HKEQCTLLTSEKE----ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK 352

Query: 577  S--EEVEANSGGIEPEHGLGSEECNPLNMSIEAELV--IEQMKEQHHRDICCLRLELEDK 632
            +  E++E + G +  E      E   +     A+L   I+QM  Q       LR + E  
Sbjct: 353  NLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE----LREQKEKS 408

Query: 633  VRHYEKQLDETVVSCKKAQE--------------NMKQRHENETHTLEKQISDLKNEIAE 678
             R   ++L++ + + +K +E               +++  E E  +L++++S +K E+ +
Sbjct: 409  ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468

Query: 679  L-----QGQAAVLKEAHHEATCRHEEE-KKQLQVKLEEEKTHLQEKLRLQHEMELK-ARL 731
            +     + Q A L++ H +   R E+E  K+LQ +  E +  ++  L       LK ++ 
Sbjct: 469  VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528

Query: 732  TQAQASFEREREGLQSSAW---TEEKVRGLTQELEQFHQE--QLTSLVEKHTLEKEELRK 786
             + Q S   E   LQ  A    +E K+R L QE E +     +L S +EK   E +   K
Sbjct: 529  KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588

Query: 787  EL------------------LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 828
            +L                  +EKH+ EL+  + + +     +   ++ Q+Q++ +K+ E+
Sbjct: 589  DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648

Query: 829  CESALQSL----EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE---AQELLKETLK 881
            CE   ++L    E  ++  ++++ E+  E+    + E + L+ E +E   A+  L+E L 
Sbjct: 649  CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708

Query: 882  REKTTSLVLTQEREMLEKTYKEH----LNSMVVERQQLLQDLEDLRNVSETQQSLL---S 934
              K  +  + QE E      K H    ++S++ E +  +Q  E        Q  LL    
Sbjct: 709  VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768

Query: 935  DQILELKSSH----KRELREREEVLCQAGAS-------------------EQLASQRLER 971
            D+ L+   +H    + +++  E  L QA A                    EQLA  + + 
Sbjct: 769  DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828

Query: 972  LEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSM 1031
            L++E   ER  +  ++  +E   K  C   D  + ++   + +L+ +  EM+Q    L+ 
Sbjct: 829  LDLE--TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886

Query: 1032 LQSGCQVIGEEE--------VEGDGALSLLQQGE--------QLLEENGDVLLSLQRAHE 1075
            +       G +E        VE +  +  +++G+        Q L    D +  L   +E
Sbjct: 887  VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946

Query: 1076 QAVKENVKMATEISR----LQQRLQK--LEPGLVMSSCLDEPATEFF------------- 1116
               K   K   ++ +    +Q+ L+K  L+    +   L+  A E               
Sbjct: 947  TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006

Query: 1117 --GNTAEQTEPF--LQQNRTKQVEGVTRRH--VLSDLEDDEVRDLGSTGTSSVQRQEVKI 1170
               N+A  ++    L+ N+ +Q+E +T  H   L+D+     + L        +  E+++
Sbjct: 1007 AQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL 1066

Query: 1171 EESEASVEGFSE------LENSEETRTESWELKNQ-------ISQLQEQLMMLCADCDRA 1217
            +E E  V    +       E  E  +  +W LK +       +++LQEQL    A  +  
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITW-LKEEGVKQDTTLNELQEQLKQKSAHVNSL 1125

Query: 1218 SEKKQDLLFDVSVLK----KKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEEL 1266
            ++ +  L   +  L+    K LK    + E   + K+L E+  R+   L        EE 
Sbjct: 1126 AQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF 1185

Query: 1267 RMMETRYDEALENNKELTAEVFRLQDELKKMEEV----TETFLSLEKSYDEVKIENEELN 1322
            + +++ ++++ ++ ++ + E  +L +EL    ++    TE  L   K+ + + I + + N
Sbjct: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA-KTNELINISSSKTN 1244

Query: 1323 VLVLRL---QGKIEKLQESV-VQRCDCCLWEASLENLEIEPDG---NILQLNQTLEECVP 1375
             ++ R+   Q +  K++E++ ++ C     EA L  L  E +    +  Q    LEE   
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304

Query: 1376 RVRSVHHVIEECKQENQYLE---GNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE 1432
            +++S+   IE    E + L+   GN Q     K   I  L   +  +     +  + + E
Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364

Query: 1433 ENTTLLGFQDK------HFQHQATIAELEL-----------EKTKLQELTRKLKERVTIL 1475
            +   +     +        Q+  +++E E            EK +L +  + L  +V  L
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424

Query: 1476 VKQK-----------DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENS 1524
             K+K           +  S  +K+ + +   H  Q T  E+Q ++EL   E+ +  ++ +
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRFTQH--QNTVKELQIQLELKSKEAYEKDEQIN 1482

Query: 1525 ILRNEITTLNE---------EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENL 1575
            +L+ E+   N+         ED  S ++    N   E   Q    ++ E+   QK +E +
Sbjct: 1483 LLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIE-I 1541

Query: 1576 KKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQ 1635
            +     LK  NQQ D+E+ EL QK    QE  +E + R+ E    +EK      +   E 
Sbjct: 1542 ESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEA---EEK------ILTLEN 1592

Query: 1636 EKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDL 1695
            + +++K ELE  K            EL  V +     ++E   L+D LE           
Sbjct: 1593 QVYSMKAELETKK-----------KELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641

Query: 1696 SDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSA 1755
               +QKI+++    ++LL + E   E+      K  +S L E  + T  QE++   H   
Sbjct: 1642 RKAEQKIAAI---KKQLLSQMEEKEEQYK----KGTESHLSE--LNTKLQEREREVHILE 1692

Query: 1756 SLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSD----LRVTQQEKEALKQEVMSLHKQLQ 1811
                 + +SQ +   +  + +NV     + ++D    ++ T +EK ++ Q  ++  ++L 
Sbjct: 1693 EKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLL 1752

Query: 1812 NAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELT 1871
               G+     +++H       Q+RL   KL+H   ++ +         Q+M+ + + EL 
Sbjct: 1753 QRVGQEKEETVSSHFEMRCQYQERLI--KLEHAEAKQHED--------QSMIGHLQEELE 1802

Query: 1872 HSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNS 1931
               +K   + +       +H+   G  N   Q K +L+   D  QK       K      
Sbjct: 1803 EKNKKYSLIVA-------QHVEKEGGKNNI-QAKQNLENVFDDVQKT---LQEKELTCQI 1851

Query: 1932 LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1991
            LEQ+++   L++  +++K+V      +EM+ L S            LQ LQQ      P 
Sbjct: 1852 LEQKIK--ELDSCLVRQKEV----HRVEMEELTSKYEK--------LQALQQMDGRNKPT 1897

Query: 1992 EQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVK 2051
            E   +   +  ++  +   L   +E + ++        E+    + + ++ +++ L++++
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957

Query: 2052 RLLQEKVNQLKEQLC--KNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYL 2105
            +  Q+++  LK++    +  K     +DL +++   LK L + E   + A+K+  L
Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQL-MREFNTQLAQKEQEL 2012



 Score =  202 bits (514), Expect = 3e-51
 Identities = 403/1935 (20%), Positives = 822/1935 (42%), Gaps = 350/1935 (18%)

Query: 262  RQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIEN 321
            RQ+   L M+  + +  R+      T     R      +      +E+ L T Q+     
Sbjct: 371  RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK----- 425

Query: 322  SQEILKALDFSLDGNINLTELT-----LALENELLVTKNSIHQAALASFKAEIRHLLERV 376
            ++E  + L   +D  I   E T     ++L+ EL   K  +      S + +I  L    
Sbjct: 426  TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL---- 481

Query: 377  DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 436
             Q + EKE  R + +  +KL++      +    A+E+     L+   E+ ++   AL+ E
Sbjct: 482  -QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE-E 539

Query: 437  LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLEN--AEKL 494
            L  +++ IL ++  +  +L+QE E  +T    +   L  SL+EN     +L  +  AEK 
Sbjct: 540  LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599

Query: 495  AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE- 553
               + +T  ++++   + + K         +  L  E+L  ++ +Y+ +   L+++ ++ 
Sbjct: 600  KHNKEITVMVEKHKTELESLK-------HQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652

Query: 554  -----------LQSELEEYRAQGRVLRLPLKNSPSEEVEAN-SGGIEPEHGLGSEECNPL 601
                        Q+ +EE   +  + +L +K +  E + +  S  ++  H L  EE + L
Sbjct: 653  KETLLKDKEIIFQAHIEEMN-EKTLEKLDVKQTELESLSSELSEVLKARHKL-EEELSVL 710

Query: 602  -----NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KAQENMK 655
                  M  E E  +++ K  H + +  +  E E  ++  EK L + +   +   +E  K
Sbjct: 711  KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770

Query: 656  QRHENETHTLEKQISDLKNEIAELQGQAAVL------KEAHHEATCRHEEEKKQLQVKLE 709
               E++ H +E   +D+K    ELQ  +A L      + A HE T  +EE+  QLQ KL 
Sbjct: 771  HLKEHQAH-VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829

Query: 710  EEKTH--LQEKLRLQHEMELKARLTQAQASFEREREGLQ----SSAWTEEKVRGLTQ--- 760
            + +T   L  K   + E + K   T+  A   + ++ +Q     ++  E+KV+ LTQ   
Sbjct: 830  DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYE 889

Query: 761  -ELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKM---ETECNRRTSQIEA 816
             +LE  ++EQ     ++  +EKE +  ++ E  ++E++   +K+   E   +    + E 
Sbjct: 890  SKLEDGNKEQ--EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 947

Query: 817  QFQSD---CQKVTERCESALQSL-------EGRYRQELKDLQEQQREEKSQWEFEKDELT 866
            +F++     +KV ++ +   ++L       E + ++EL++   +  +++ Q+  +  E+ 
Sbjct: 948  KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007

Query: 867  QE----CAEAQELLKETLKREKTTSLVLTQEREMLE--KTYKEHLNSMVVERQQL--LQD 918
            Q      ++A   L ET ++E+  SL     RE+ +    +++ LN    E Q++  +Q 
Sbjct: 1008 QANSAGISDAVSRL-ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL 1066

Query: 919  LEDLRNVSETQQSLL---------SDQILELKSSHKRE---LREREEVLCQAGA------ 960
             E  + V+E +Q +L         + +I  LK    ++   L E +E L Q  A      
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126

Query: 961  -SEQLASQRLERLEMEHDQERQE---MMSKLLAMENIHKATCETADRERAEMSTEISRLQ 1016
              E      LE+LE++ ++  +E   +  +L+ ++ +       A+ ++ ++S   S+L+
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML-------AEEDKRKVSELTSKLK 1179

Query: 1017 SKIKEMQQATSPLSMLQSGCQ--VIGEEEVEGDGALSL---LQQGEQLLEENGDVLLSLQ 1071
            +  +E Q   S         +   +  +++  + A+ L    ++ E LLE   + L+++ 
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239

Query: 1072 RAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNR 1131
             +   A+       + IS  Q R  K++  L++ +C              Q     ++  
Sbjct: 1240 SSKTNAI------LSRISHCQHRTTKVKEALLIKTCT-------VSELEAQLRQLTEEQN 1286

Query: 1132 TKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELEN------ 1185
            T  +      H L + ++++++ + +   S V  +E   +E     +  SE E+      
Sbjct: 1287 TLNISFQQATHQLEE-KENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLK 1345

Query: 1186 ---SEE------TRTESWELKNQISQLQEQLMMLCADCDRA---SEKK------------ 1221
               SE        + E  E K +IS L +QL  L      +   SEK+            
Sbjct: 1346 KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE 1405

Query: 1222 ---------QDLLFDVSVL-KKKLKMLERIPEASPKY----KLLYEDVSRENDCLQEELR 1267
                     QDL F V  L K+K+  LE++ + S K+    K      ++  + ++E   
Sbjct: 1406 EKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465

Query: 1268 MMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNV-LVL 1326
             +E +  EA E ++++      L  + K+ +      L  E   D+ K+E +E N+   L
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFD-----CLKGEMEDDKSKMEKKESNLETEL 1520

Query: 1327 RLQ-GKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQ-LNQTLE----ECVPRVRSV 1380
            + Q  +I +L++ + Q+            +EIE    +L+  NQ  +    E V +++  
Sbjct: 1521 KSQTARIMELEDHITQK-----------TIEIESLNEVLKNYNQQKDIEHKELVQKLQHF 1569

Query: 1381 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1440
              + EE  ++N+  E   ++L     +++  +   ++T ++     N  +  +   L   
Sbjct: 1570 QELGEE--KDNRVKEAEEKIL--TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKAL 1625

Query: 1441 QDKHFQHQATIAELELEK-TKLQELTRKLKERVTILVKQKDVLSHGEKEEE-----LKAM 1494
            +D+          LE E   KL EL RK ++++  + KQ  +LS  E++EE      ++ 
Sbjct: 1626 EDR----------LESESAAKLAELKRKAEQKIAAIKKQ--LLSQMEEKEEQYKKGTESH 1673

Query: 1495 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGT------LN 1548
            + +L     E +++V +L    EKL+   S+  ++  TL    S  N+   T        
Sbjct: 1674 LSELNTKLQEREREVHIL---EEKLK---SVESSQSETLIVPRSAKNVAAYTEQEEADSQ 1727

Query: 1549 GSQEEMWQKTETVKQENAA-----VQKMVENLKKQIS---ELKIKNQQ--LDLENTELSQ 1598
            G  ++ +++  +V Q N       +Q++ +  ++ +S   E++ + Q+  + LE+ E  Q
Sbjct: 1728 GCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQ 1787

Query: 1599 KNSQN-----QEKLQELNQRLTEMLCQK-EKEPGNSALEEREQEKFNLKEELERCKVQSS 1652
               Q+     QE+L+E N++ + ++ Q  EKE G + +    Q K NL+           
Sbjct: 1788 HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI----QAKQNLE----------- 1832

Query: 1653 TLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1712
             +   ++  L E ++   I++Q          K+K+L  C                   L
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQ----------KIKELDSC-------------------L 1863

Query: 1713 LKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLE 1772
            +++KE    E+     K  K   L+      K  +   E+     KS LV  Q K+    
Sbjct: 1864 VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLV--QPKL---- 1917

Query: 1773 DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQ 1832
              + N+  Q + ++  L   ++EK+ L +E++ L K L+    +        H   L   
Sbjct: 1918 --LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE--------HQQELEIL 1967

Query: 1833 QKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE-----------KVRQLE 1881
            +K    ++ + +  E++ L  + N  L+ +++    +L    +           K +++E
Sbjct: 1968 KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027

Query: 1882 SNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKV-SQMNSLEQELETIH 1940
            + LL  HQ+  N    +    ++   LKR   ++++       ++ +++  L+ +LE + 
Sbjct: 2028 AELLESHQEETNQ--LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ 2085

Query: 1941 LENEGLKKKQVKLDEQ---------LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1991
                  KK Q KL+++         +ME+Q   +  T   S    D +L +Q+      R
Sbjct: 2086 ------KKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS----DSKLKEQEF-----R 2130

Query: 1992 EQFLQLQRQLLQAER 2006
            EQ   L+ +L + E+
Sbjct: 2131 EQIHNLEDRLKKYEK 2145



 Score =  189 bits (480), Expect = 2e-47
 Identities = 374/1811 (20%), Positives = 766/1811 (42%), Gaps = 297/1811 (16%)

Query: 364  SFKAEIRHLLERVDQVVRE--KEKL-----RSDLDKAEKLKSLMASEVDDHHAAIERRNE 416
            SF  +++  +  V+ + R   KE L     +  L +    +SL   ++D   A+ +  ++
Sbjct: 60   SFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSD 119

Query: 417  YNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS 476
                 +D E ++ +    N     +EQ++Q+  +    +E+ +   + + + +     + 
Sbjct: 120  -----MDSEAEDLVG---NSDSLNKEQLIQRLRR----MERSLSSYRGKYSELVTAYQML 167

Query: 477  LKENSRLENELLENAEK-LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQ 535
             +E  +L+  L ++ +K L     L  +LQ + +              A+  LQEE    
Sbjct: 168  QREKKKLQGILSQSQDKSLRRIAELREELQMDQQ--------------AKKHLQEEFDAS 213

Query: 536  MRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEV----EANSGGIEP-- 589
            +  E ++   VLQ QV  L+  L        VL+   +  P  EV    E      EP  
Sbjct: 214  LE-EKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVV 272

Query: 590  EHGLGSEECNPLNMSIEA-ELVIEQMKE--QHHRDICCLRLELEDKVRHYEKQLDETVVS 646
            E G   +    L   ++  E ++++ KE  Q H++ C L   L  +    ++QLDE +  
Sbjct: 273  EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL---LTSEKEALQEQLDERLQE 329

Query: 647  CKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVL----KEAHHEATCRHEEEKK 702
             +K    +K  H  E   L  Q+ D KN I +L+    ++    K   HE     EEE  
Sbjct: 330  LEK----IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIA 385

Query: 703  QLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQEL 762
            QL+ ++++  T   E+LR Q E          +A+FE   + L ++  TEE  R L  E+
Sbjct: 386  QLRSRIKQMTTQ-GEELREQKEKS-------ERAAFEELEKALSTAQKTEEARRKLKAEM 437

Query: 763  EQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDC 822
            +    EQ+ ++ +    E+  L++EL     R  QE  + M+     + ++++   + + 
Sbjct: 438  D----EQIKTIEKTSEEERISLQQEL----SRVKQEVVDVMKKSSEEQIAKLQKLHEKEL 489

Query: 823  QKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKR 882
             +  +     LQ+ E  +++++K   E+ + E  +   EK++      E  EL K+ +  
Sbjct: 490  ARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILT 549

Query: 883  EKTTSLV-LTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELK 941
            E    L  L QE E       E  +S+    Q+     +DL    E +++  + +I  + 
Sbjct: 550  ESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMV 609

Query: 942  SSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETA 1001
              HK EL   +         + L +++L+ L+ ++  E +++  K    +       E  
Sbjct: 610  EKHKTELESLKH------QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII 663

Query: 1002 DRERAEMSTE--ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
             +   E   E  + +L  K  E++  +S LS +      + EE       LS+L+     
Sbjct: 664  FQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE-------LSVLKDQTDK 716

Query: 1060 LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNT 1119
            +++  +  +  Q+ H Q   +++    E+S     +Q+ E  L               + 
Sbjct: 717  MKQELEAKMDEQKNHHQQQVDSIIKEHEVS-----IQRTEKALK--------------DQ 757

Query: 1120 AEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG 1179
              Q E  L++ R K ++   + HV  +LE D            ++R E +++++ A ++ 
Sbjct: 758  INQLELLLKE-RDKHLKE-HQAHV-ENLEAD------------IKRSEGELQQASAKLDV 802

Query: 1180 FSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE 1239
            F   +++   +T+++E   Q++QLQ++L+ L  + +R    KQ  + +V   KK +    
Sbjct: 803  FQSYQSATHEQTKAYE--EQLAQLQQKLLDL--ETERILLTKQ--VAEVEAQKKDV--CT 854

Query: 1240 RIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENN-------KELTAE----VF 1288
             +     + + L + + ++N  ++++++ +   Y+  LE+        K++  E    + 
Sbjct: 855  ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMIL 914

Query: 1289 RLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLW 1348
            ++++  KK  E+    LS ++  D + I NEE        + K+EK+++   +       
Sbjct: 915  QMREGQKKEIEILTQKLSAKE--DSIHILNEEYETKFKNQEKKMEKVKQKAKEM------ 966

Query: 1349 EASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE 1408
            + +L+   ++ +    +L + LE            +E  ++E Q+   N ++LE  +A+ 
Sbjct: 967  QETLKKKLLDQEA---KLKKELENTA---------LELSQKEKQF---NAKMLEMAQANS 1011

Query: 1409 --IAWLHGTIQTHQ-ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELT 1465
              I+     ++T+Q E+     +V   E   ++   +K    QA   + E+ + +LQE  
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ-EIHEIQLQE-- 1068

Query: 1466 RKLKERVTILVKQKDVLSHGEKEEE------LKAMMHDLQITCSEMQQKVELLRYESEKL 1519
               KE+    +KQK +L   EKEE       LK        T +E+Q++++        L
Sbjct: 1069 ---KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSL 1125

Query: 1520 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1579
             Q+ + L+  +  L E D   +LK  T    QE++ +     +++   V ++   LK   
Sbjct: 1126 AQDETKLKAHLEKL-EVDLNKSLKENTF--LQEQLVELKMLAEEDKRKVSELTSKLKTTD 1182

Query: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN 1639
             E +      +  N  L  K+ + ++  +EL  +L   +C K+ E   + LE +  E  N
Sbjct: 1183 EEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLD--ICCKKTE---ALLEAKTNELIN 1237

Query: 1640 LKEE--------LERCKVQSSTLVSSL---EAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
            +           +  C+ +++ +  +L      +SE++ Q   + +E + L    ++   
Sbjct: 1238 ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297

Query: 1689 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1748
                  L + + +I S+ +  E L+ EKEAL +E  +                       
Sbjct: 1298 -----QLEEKENQIKSMKADIESLVTEKEALQKEGGN----------------------- 1329

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
              + Q+AS K   +   +K     +  +N+N  ++ MK +L+  + E  +L +++  L+ 
Sbjct: 1330 --QQQAASEKESCITQLKK-----ELSENINA-VTLMKEELKEKKVEISSLSKQLTDLNV 1381

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1868
            QLQN+        ++   + + + +K+   +K + L+++ Q L ++ +            
Sbjct: 1382 QLQNS------ISLSEKEAAISSLRKQYDEEKCE-LLDQVQDLSFKVD------------ 1422

Query: 1869 ELTHSREKVRQLE-----SNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPAN 1923
              T S+EK+  LE     SN   + +K      T +    ++L +     Q + +   A 
Sbjct: 1423 --TLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI-----QLELKSKEAY 1475

Query: 1924 RKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQ 1983
             K  Q+N L++EL+  +   + LK +   +++   +M+   S           + +L  Q
Sbjct: 1476 EKDEQINLLKEELDQQNKRFDCLKGE---MEDDKSKMEKKESNL---------ETELKSQ 1523

Query: 1984 QACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEV 2043
             A       + ++L+  + Q     + L E L+N   + +            +E +  E+
Sbjct: 1524 TA-------RIMELEDHITQKTIEIESLNEVLKNYNQQKD------------IEHK--EL 1562

Query: 2044 EQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKN 2103
             QKL+  + L +EK N++KE   K    +  V  +  E     K LE      K+ E++ 
Sbjct: 1563 VQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEEL 1622

Query: 2104 YLLEEKIASLS 2114
              LE+++ S S
Sbjct: 1623 KALEDRLESES 1633



 Score =  169 bits (427), Expect = 3e-41
 Identities = 339/1583 (21%), Positives = 663/1583 (41%), Gaps = 246/1583 (15%)

Query: 628  ELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLK 687
            E ED V + +    E ++   +  E     +  +   L      L+ E  +LQG   +L 
Sbjct: 123  EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG---ILS 179

Query: 688  EAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQ 746
            ++  ++  R  E +++LQ+  ++ K HLQE+      E +    + Q Q S  ++R  L+
Sbjct: 180  QSQDKSLRRIAELREELQMD-QQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQR--LR 236

Query: 747  SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
            +     + ++ L Q                      E + E+  K +    +G   +E  
Sbjct: 237  NGPMNVDVLKPLPQL---------------------EPQAEVFTKEENPESDGEPVVEDG 275

Query: 807  CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 866
             + +T +   Q     + + +RC+  +QS    ++++   L      EK   + + DE  
Sbjct: 276  TSVKTLETLQQRVKRQENLLKRCKETIQS----HKEQCTLLTS----EKEALQEQLDERL 327

Query: 867  QECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS 926
            QE     E +K+    EKT  +   ++ + L +  ++    ++ E ++ + +  +++   
Sbjct: 328  QEL----EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKE-- 381

Query: 927  ETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSK 986
                    ++I +L+S  K+   + EE+  Q   SE+ A + LE+  +   Q+ +E   K
Sbjct: 382  --------EEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA-LSTAQKTEEARRK 432

Query: 987  LLA-MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
            L A M+   K   +T++ ER  +  E+SR++ ++ ++ + +S             EE++ 
Sbjct: 433  LKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS-------------EEQI- 478

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                  L +  E+ L      L    +  E+  +E +K+A E S+ +      E     S
Sbjct: 479  ----AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSS--- 1162
              L+E   +      E         R  Q E  T R  + +LE    + L      S   
Sbjct: 535  LALEELELQKKAILTESENKL----RDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590

Query: 1163 -----VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI--SQLQEQLMMLCADCD 1215
                  ++ +   E +    +  +ELE+ +  +   W  K Q+   Q Q ++  L   C+
Sbjct: 591  AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE 650

Query: 1216 RASE---KKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETR 1272
            +  E   K ++++F   + +   K LE++                  D  Q EL  + + 
Sbjct: 651  QEKETLLKDKEIIFQAHIEEMNEKTLEKL------------------DVKQTELESLSSE 692

Query: 1273 YDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKI 1332
              E L+   +L  E+  L+D+  KM++  E  +  +K++ + ++++             I
Sbjct: 693  LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS-------------I 739

Query: 1333 EKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ 1392
             K  E  +QR +  L +             I QL   L+E    ++     +E  + + +
Sbjct: 740  IKEHEVSIQRTEKALKD------------QINQLELLLKERDKHLKEHQAHVENLEADIK 787

Query: 1393 YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1452
              EG  Q        + +      Q++Q     Q +           ++++  Q Q  + 
Sbjct: 788  RSEGELQ--------QASAKLDVFQSYQSATHEQTK----------AYEEQLAQLQQKLL 829

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE-ELKAMMHDLQITCSEMQQKVEL 1511
            +LE E+  L       K+   +  ++KDV +  +  + +++ +M  L+   SEM+QKV+ 
Sbjct: 830  DLETERILL------TKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883

Query: 1512 LR--YESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1569
            L   YES KL+  N         L E++   N+ L    G ++E+    E + Q+ +A +
Sbjct: 884  LTQVYES-KLEDGNKEQEQTKQILVEKE---NMILQMREGQKKEI----EILTQKLSAKE 935

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +  L ++  E K KNQ+  +E  ++ QK  + QE L+   ++L +   + +KE  N+A
Sbjct: 936  DSIHILNEEY-ETKFKNQEKKME--KVKQKAKEMQETLK---KKLLDQEAKLKKELENTA 989

Query: 1630 LEEREQEK-FNLKEELERCKVQS---STLVSSLEAELSE-VKIQTHIVQQE--------N 1676
            LE  ++EK FN K  LE  +  S   S  VS LE    E ++  T + ++E         
Sbjct: 990  LELSQKEKQFNAK-MLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048

Query: 1677 HLLKDELEKMKQLHRC------PDLSDFQQKISSVLSYNEKLLKEKEALSEE-------L 1723
              L  + E+++++H         ++++ +QKI       E++ KE   L EE       L
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108

Query: 1724 NSCVDKLAKSSLLEHRIATMKQEQKS-WEHQSASLKSQLVAS---QEKVQNLEDTVQNVN 1779
            N   ++L + S   + +A  + + K+  E     L   L  +   QE++  L+   +   
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168

Query: 1780 LQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAG--GKSWAPEIATHPSGLHNQQKRLS 1837
             ++S + S L+ T +E ++LK      +K L++     K  + E+A        + + L 
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228

Query: 1838 WDKLDHLMN---EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL--LPKHQKHL 1892
              K + L+N    +   +       Q      K  L      V +LE+ L  L + Q  L
Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288

Query: 1893 NPS---GTMNPTEQEKL---------SLKRECDQFQKE----QSPANRKVSQMNSLEQEL 1936
            N S    T    E+E           SL  E +  QKE    Q  A+ K S +  L++EL
Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348

Query: 1937 ----ETIHLENEGLKKKQVK---LDEQLMEMQ-HLRSTATPSPSPHAWDLQLLQ--QQAC 1986
                  + L  E LK+K+V+   L +QL ++   L+++ + S    A      Q  ++ C
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1408

Query: 1987 PMVPREQFLQLQRQLLQAERINQHLQ-EELENRTSE-TNTPQGNQEQLVTVMEERMIEVE 2044
             ++ + Q L  +   L  E+I+   Q ++  N+ SE     Q    Q    ++E  I++E
Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468

Query: 2045 QKLKLVKRLLQEKVNQLKEQL-CKNTKADAMVKDLYVENAQLLK-----ALEVTEQRQKT 2098
             K K       E++N LKE+L  +N + D +  ++  + +++ K       E+  Q  + 
Sbjct: 1469 LKSKEAYE-KDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARI 1527

Query: 2099 AEKKNYLLEE--KIASLSNIVRN 2119
             E ++++ ++  +I SL+ +++N
Sbjct: 1528 MELEDHITQKTIEIESLNEVLKN 1550



 Score =  116 bits (291), Expect = 2e-25
 Identities = 240/1118 (21%), Positives = 456/1118 (40%), Gaps = 180/1118 (16%)

Query: 1083 KMATEISRLQQRLQKLEPGLVMSSCLDEPA-----TEFFGNTAEQ---------TEPFLQ 1128
            K+  +IS  QQ+LQ+       SS    P      T  F    ++         T+ F Q
Sbjct: 4    KLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63

Query: 1129 --QNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENS 1186
              Q R   VE + R  +   L     ++     +S      + ++ S AS +  S++++ 
Sbjct: 64   KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSE 123

Query: 1187 EETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASP 1246
             E    + +  N+  QL ++L  +         K  +L+    +L+++ K L+ I   S 
Sbjct: 124  AEDLVGNSDSLNK-EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQ 182

Query: 1247 KYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLS 1306
               L      R    L+EEL+M +       +  K L  E     +E  +   V +T +S
Sbjct: 183  DKSL------RRIAELREELQMDQ-------QAKKHLQEEFDASLEEKDQYISVLQTQVS 229

Query: 1307 LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQL 1366
            L K     ++ N  +NV VL+   ++E   E   +  +        +   +  DG  ++ 
Sbjct: 230  LLKQ----RLRNGPMNVDVLKPLPQLEPQAEVFTKEEN-----PESDGEPVVEDGTSVKT 280

Query: 1367 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ 1426
             +TL++   RV+   ++++ CK+                         TIQ+H+E    Q
Sbjct: 281  LETLQQ---RVKRQENLLKRCKE-------------------------TIQSHKE----Q 308

Query: 1427 NQVILEENTTLLGFQDKHFQHQATIAELEL-EKTKLQELTRKLKERVTILVKQKDVLSHG 1485
              ++  E   L    D+  Q    I +L + EKTKL    R  K  +  L + K ++   
Sbjct: 309  CTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVI-- 366

Query: 1486 EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLG 1545
                E K  MH+   T    ++++  LR   +++  +   LR +    +E  +   L+  
Sbjct: 367  ---AETKRQMHE---TLEMKEEEIAQLRSRIKQMTTQGEELREQ-KEKSERAAFEELEKA 419

Query: 1546 TLNGSQEEMWQKTETVKQE-NAAVQKMVENLKKQISELKIKNQQ----LDLENTELSQKN 1600
                      QKTE  +++  A + + ++ ++K   E +I  QQ    +  E  ++ +K+
Sbjct: 420  LSTA------QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKS 473

Query: 1601 SQNQ-EKLQELNQRLTEMLCQKEKEPGNSALEEREQE-KFNLKEELERCKVQSSTLVSSL 1658
            S+ Q  KLQ+L+++    L +KE+E     L+ RE+E +  +K  LE  K QS  L  S 
Sbjct: 474  SEEQIAKLQKLHEK---ELARKEQEL-TKKLQTREREFQEQMKVALE--KSQSEYLKISQ 527

Query: 1659 EAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1718
            E E  E      +  Q+  +L +   K++ L +  +   ++ +I  + S  EK L+E + 
Sbjct: 528  EKEQQESLALEELELQKKAILTESENKLRDLQQ--EAETYRTRILELESSLEKSLQENKN 585

Query: 1719 LSEELNSCVDKLAKSSLLEHRIATMKQEQKS------------WEHQSASLKSQLVASQE 1766
             S++L   V   A+ +     I  M ++ K+            W  +   LK Q     E
Sbjct: 586  QSKDL--AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEME 643

Query: 1767 KV-----QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQ-EVMSLHKQLQNAGGKSWAP 1820
            K+     Q  E  +++  +       ++     EK  +KQ E+ SL  +L          
Sbjct: 644  KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV--LKARH 701

Query: 1821 EIATHPSGLHNQQKRLSWD---KLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKV 1877
            ++    S L +Q  ++  +   K+D   N  QQ +    +  +  +Q T+  L   ++++
Sbjct: 702  KLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL---KDQI 758

Query: 1878 RQLESNL------LPKHQKHL-NPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMN 1930
             QLE  L      L +HQ H+ N    +  +E E      + D FQ  QS  +    Q  
Sbjct: 759  NQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHE---QTK 815

Query: 1931 SLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVP 1990
            + E++L  +  +   L+ +++ L +Q+ E++  +         H   +Q L QQ      
Sbjct: 816  AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ------ 869

Query: 1991 REQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV 2050
                  L++Q  + E+  + L +  E++  + N  Q   +Q++   E  ++++ +  K  
Sbjct: 870  ------LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKE 923

Query: 2051 KRLLQEKV-------------------NQLKEQLCKNTKA----DAMVKDLYVENAQLLK 2087
              +L +K+                   NQ K+      KA    + + K L  + A+L K
Sbjct: 924  IEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983

Query: 2088 -----ALEVTEQRQKTAEKKNYLLEEKIASLSNIVRNL 2120
                 ALE++++ ++   K   + +   A +S+ V  L
Sbjct: 984  ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRL 1021



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 80/334 (23%), Positives = 142/334 (42%), Gaps = 61/334 (18%)

Query: 317  EGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERV 376
            E + +  E L+AL   +DG    TEL L    E     + +    L++ +A+   L  ++
Sbjct: 1875 EELTSKYEKLQALQ-QMDGRNKPTEL-LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKL 1932

Query: 377  DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 436
                REK+KL  ++ + +K                      +LR L +E+++ +  LK E
Sbjct: 1933 AGAEREKQKLGKEIVRLQK----------------------DLRMLRKEHQQELEILKKE 1970

Query: 437  LRKEREQILQQAG-----KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENA 491
              +ERE+ ++Q       K    L+Q + +  T+       L +++KE      E+   A
Sbjct: 1971 YDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEV--EA 2028

Query: 492  EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQV 551
            E L  ++  TN+L + +    AEK  DL  ++  +   EE L     E   + R LQ Q+
Sbjct: 2029 ELLESHQEETNQLLKKI----AEKDDDLKRTAKRY---EEILDAREEEMTAKVRDLQTQL 2081

Query: 552  DELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVI 611
            +ELQ + ++   Q             EE   N      E  L ++      +  +++L  
Sbjct: 2082 EELQKKYQQKLEQ-------------EENPGNDNVTIME--LQTQLAQKTTLISDSKLKE 2126

Query: 612  EQMKEQHHRDICCLRLELEDKVRHYEKQLDETVV 645
            ++ +EQ H         LED+++ YEK +  T V
Sbjct: 2127 QEFREQIHN--------LEDRLKKYEKNVYATTV 2152


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  207 bits (527), Expect = 9e-53
 Identities = 382/1789 (21%), Positives = 736/1789 (41%), Gaps = 204/1789 (11%)

Query: 341  ELTLALENELLVTKNSIHQAALASFKAEIRHLL-----------ERVDQVVREKEKLRSD 389
            E  L  E E L  +    Q  L   + ++R L            E+  Q +R +++LR  
Sbjct: 250  ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309

Query: 390  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 449
             ++  + +     E  +     E R E  LR+  EE +E+      +LR+E+E+  ++  
Sbjct: 310  QEEERREQQEERREQQERREQQEERREQQLRREQEERREQ------QLRREQEEERREQQ 363

Query: 450  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509
             +R + E+  E+    E  +R    L  ++  R E + L   ++L   + L  + Q   E
Sbjct: 364  LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ-LRREQQLRREQQLRREQQLRRE 422

Query: 510  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE----LQSELEEYRAQG 565
              L  +             QEE   + ++E ER+ + L+ + +E    L+ E E  R + 
Sbjct: 423  QQLRRE-------------QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQ 469

Query: 566  RVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ-MKEQHHRDICC 624
               +  LK    EE       +E E     +E     +  E E   EQ +K Q   +   
Sbjct: 470  ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529

Query: 625  LRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAA 684
             RL  E ++R  +++           +E + +R E +    E++   LK E         
Sbjct: 530  QRLRSEQQLRREQEE----------RREQLLKREEEKRLEQERREQRLKRE--------- 570

Query: 685  VLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKL------RLQHEMELKARLTQAQASF 738
              +E   +   + EEE++Q ++K E+E+  L+++L      RL+ E   + RL + +   
Sbjct: 571  --QEERRDQLLKREEERRQQRLKREQEE-RLEQRLKREEVERLEQEERREQRLKREEPEE 627

Query: 739  EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQREL-Q 797
            ER ++ L+S    E + + L +E ++  +++L    E+  LE+   R+   E+ ++EL +
Sbjct: 628  ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687

Query: 798  EGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ 857
            E +E+       R  + + Q +S+      +  S  +  EG+ R++ ++ + ++RE + Q
Sbjct: 688  EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747

Query: 858  WEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQ 917
            W+ E+    Q+  E Q       +R+ T      Q  E  E+  ++ L++    R+Q  +
Sbjct: 748  WQEEERAHRQQQEEEQ-------RRDFTWQ---WQAEEKSERG-RQRLSARPPLREQRER 796

Query: 918  DLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQL-ASQRLERLEMEH 976
             L         Q+ L  +   E K   +R+ RERE+ L      EQL   +R ++L+ E 
Sbjct: 797  QLRAEERQQREQRFLPEE---EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE 853

Query: 977  D---QERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1033
            D   ++++   S+    +   +   E   + R         LQ ++++ QQ      +LQ
Sbjct: 854  DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ------LLQ 907

Query: 1034 SGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQ 1093
               + +  EE E        +Q  Q  EE       LQ+  EQ ++E         R ++
Sbjct: 908  EEEEELQREERE---KRRRQEQERQYREEE-----QLQQEEEQLLRE--------EREKR 951

Query: 1094 RLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVR 1153
            R Q+ E        L +   +  G   E+     ++ + ++ E + +       E+ E R
Sbjct: 952  RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011

Query: 1154 DLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCAD 1213
                      ++ E++ EE +   E   +    E  R   +  + ++ Q +EQL+    +
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQYREEEELQQEEEQLLGEERE 1069

Query: 1214 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM---- 1269
              R  E ++    +  + +++ ++L   PE   + +   E   RE + LQ+E   +    
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE--RERQCREEEELQQEEEQLLREE 1127

Query: 1270 -ETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1328
             E R  + LE       EV + +++L + E        LE+ Y E +   +E   L+   
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187

Query: 1329 QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLN-QTLEECVPRVRSVHHVIEEC 1387
            Q K  + +E   +  +    +   +    E   + L+   +  +E   R   V+    E 
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247

Query: 1388 KQENQYLEGNTQLLEKVKAHEIAWLHGTIQ---THQERPRVQ---------NQVILEENT 1435
            +Q  Q LE ++QL ++    ++  L G  Q     QER R Q          Q+  EE  
Sbjct: 1248 EQFRQ-LE-DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305

Query: 1436 TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMM 1495
                   K  + +  + E   EK + QE  RK +E   +L ++        +E+ L+   
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER--------EEQPLRRQE 1357

Query: 1496 HDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT--LNEEDSISNLKLGTLNGSQEE 1553
             D +    E++ + +  ++    L++E  + R E     L EE      +L      Q+ 
Sbjct: 1358 RDRKFREEELRHQEQGRKF----LEEEQRLRRQERERKFLKEEQ-----QLRCQEREQQL 1408

Query: 1554 MWQKTETVKQENAAVQKMVENLKKQISELKIKNQQ-----LDLENTELSQKNSQNQEKLQ 1608
               +    ++E   + +   + K +  E +++ Q+     L+ E     +++ + +E+ Q
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468

Query: 1609 ELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQ 1668
             L +R  + L ++E++     LEE +Q +   ++E +R   +        E +  E + Q
Sbjct: 1469 LLQEREEQQLHRQERD--RKFLEEEQQLR---RQERDRKFREQELRSQEPERKFLEEEQQ 1523

Query: 1669 THIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVD 1728
             H  Q++   L++E +  +Q        D  +K        E+L +E+E   E+  S  +
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE----EEQLRQERE---EQQLSRQE 1576

Query: 1729 KLAKSSLLEHRIATMKQEQKSW--EHQSASLKSQLVASQEKVQNLEDTVQ----NVNLQM 1782
            +  K  L E ++   +QE+K    E Q    + Q    QE+ +   +  Q        Q+
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636

Query: 1783 SRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLD 1842
             R + D +  ++E +  +QE     +QL++   + +  E      G   Q +R   D+  
Sbjct: 1637 HRQERDRKFLEEEPQLRRQE---REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR-- 1691

Query: 1843 HLMNEEQQLLWQENER--LQTMVQNTKAELT---HSREKVRQ-LESNLLPKHQKHLNPSG 1896
                EEQQL  QE ER  LQ   Q  + EL       E++RQ  E   L + +++     
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY----- 1746

Query: 1897 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ 1956
                 E+E+L  +RE  Q ++++   +RK  +   L QE E   L ++   +K  + ++ 
Sbjct: 1747 -RKILEEEQLRPEREEQQLRRQE--RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQL 1803

Query: 1957 LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELE 2016
              E +  +         + W+ + LQ            L+ Q Q L+ ER  Q+  E  E
Sbjct: 1804 RQEREEQQLRPQQRDGKYRWEEEQLQ------------LEEQEQRLRQERDRQYRAE--E 1849

Query: 2017 NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
               ++  + +  QE      ++R  E E+KL+      Q+K  Q   Q+
Sbjct: 1850 QFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898



 Score =  206 bits (523), Expect = 3e-52
 Identities = 401/1881 (21%), Positives = 776/1881 (41%), Gaps = 244/1881 (12%)

Query: 325  ILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKE 384
            IL+ LD   +G ++  E  L            I + A A + A        + Q     E
Sbjct: 57   ILELLDLDSNGRVDFNEFLLF-----------IFKVAQACYYA--------LGQATGLDE 97

Query: 385  KLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI 444
            + R+  D  E L      E D      +RR E   R+L+EE  +R    + E  +E  + 
Sbjct: 98   EKRARCDGKESLLQDRRQEED------QRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG 151

Query: 445  LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENA-----EKLAEYEN 499
             +Q+ KQ   LEQ   + + EE + R R     +E  R E E L++      E+  + E 
Sbjct: 152  EEQSEKQE-RLEQRDRQRRDEELW-RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209

Query: 500  LTNKLQRNLENVLAEKFGDLDPSSAEFFLQEE-------RLTQMRNEYERQCRVLQDQVD 552
            L  +    L     E+         +   QEE       R T +R E E+    LQ++  
Sbjct: 210  LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK----LQEEEP 265

Query: 553  ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG-SEECNPLNMSIEAELVI 611
            + Q EL+E   Q R L         +E E     +  E  L   +E        E     
Sbjct: 266  QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325

Query: 612  EQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD 671
            E+ ++Q  R    LR E E++    E+QL       ++ Q+  +++ E       ++   
Sbjct: 326  ERREQQEERREQQLRREQEER---REQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 672  LKNEIAELQGQAAVLKEAH--HEATCRHEEE-KKQLQVKLEEEKTHLQEKLRLQHEMELK 728
            L+ E  +L+ +  + +E     E   R E++ +++ Q++ E++    QE+ R + + E +
Sbjct: 383  LRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441

Query: 729  ARLTQAQASFEREREGLQSSAWTEE-----KVRGLTQELEQFHQEQLTSLVEKHTLEKEE 783
             R  + +   E  R+ L+    TE      + + L ++ E+  +E+   L E+   E++E
Sbjct: 442  RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501

Query: 784  LRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE 843
             R++ L + Q E +E R K + E  R    ++ + +S+ Q   E+ E   Q L+   R+E
Sbjct: 502  RREQQLRREQEERREQRLKRQEEEER----LQQRLRSEQQLRREQEERREQLLK---REE 554

Query: 844  LKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKE 903
             K L++++RE++ + E +++   Q     +E  ++ LKRE+   L    +RE +E+  +E
Sbjct: 555  EKRLEQERREQRLKRE-QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613

Query: 904  HLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQ 963
                  ++R++  ++       SE Q+     Q+       +RE +ER E   +    E+
Sbjct: 614  ERREQRLKREEPEEERRQQLLKSEEQEERRQQQL-------RREQQERREQRLKREEEEE 666

Query: 964  LASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1023
               QRL+R   EH++ER+E        E   +       + + ++ +E    QSK+    
Sbjct: 667  RLEQRLKR---EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723

Query: 1024 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVK 1083
            +        Q G +   E+E +     S LQ  E+            +RAH Q  +E  +
Sbjct: 724  RK-------QEGQRRRQEQEEKRRRRESELQWQEE------------ERAHRQQQEEEQR 764

Query: 1084 -------MATEIS-RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEP-FLQQNRTKQ 1134
                    A E S R +QRL    P        ++   +      +Q E  FL +   K+
Sbjct: 765  RDFTWQWQAEEKSERGRQRLSARPP------LREQRERQLRAEERQQREQRFLPEEEEKE 818

Query: 1135 VEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQE--VKIEESEASVEGFSELENSEETRTE 1192
                 RR    +L+  E  +        +QR+E   +++E E  ++   E   S+E R +
Sbjct: 819  QRRRQRREREKELQFLEEEE-------QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871

Query: 1193 S---WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYK 1249
                W+L+ +  + +  L    A  ++  +++Q L  +   L+++ +   R  E   +Y+
Sbjct: 872  QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR 931

Query: 1250 LLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEK 1309
               +    E   L+EE    E R  +  E       ++ + +++L   E         EK
Sbjct: 932  EEEQLQQEEEQLLREE---REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK 988

Query: 1310 SY---DEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENL-EIEPDGNILQ 1365
             Y   +E++ E E+L    LR + +  + QE          WE       E++ +   L 
Sbjct: 989  KYREEEELQQEEEQL----LREEREKRRRQE----------WERQYRKKDELQQEEEQLL 1034

Query: 1366 LNQTLEECVPRVRSVHHVIEECKQENQYLEGNT------QLLEKVKAHEIAWLHGTIQTH 1419
              +  +  +      +   EE +QE + L G        Q LE+    E        Q  
Sbjct: 1035 REEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLL 1094

Query: 1420 QERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK 1479
            +E P  + +   +E       +++  Q +  +   E EK + QEL R+ +E   +  +++
Sbjct: 1095 REEPEKRRR---QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE 1151

Query: 1480 DVLSHGEKEEELKAMMHDLQITCSE----MQQKVELLRYESEKLQQENSILRNEITTLN- 1534
             +L    +EE  K    +L+    E     Q++ +LLR E EK +QE      E   L  
Sbjct: 1152 QLL----REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207

Query: 1535 --------EEDSISNLKLGT--------------LNGSQEEMWQKTETVKQENAAVQKMV 1572
                    +ED  S+LK                   G + E +++ E  +  +   Q+ +
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDL 1267

Query: 1573 ENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEE 1632
            ++L   + E + ++++ +    +   ++   +E+L+   Q+  +   +K +E      EE
Sbjct: 1268 QHL---LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324

Query: 1633 REQE--------KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTH-----IVQQENHLL 1679
            RE++        KF  +E+L + + +        + +  E +++        +++E  L 
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR 1384

Query: 1680 KDELE----KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSL 1735
            + E E    K +Q  RC +    +Q++      + K  +E++ LS +     ++  K   
Sbjct: 1385 RQERERKFLKEEQQLRCQER---EQQLRQ--DRDRKFREEEQQLSRQ-----ERDRKFRE 1434

Query: 1736 LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE 1795
             E ++   ++E+K  E +    + +    +E+ Q L++  +    Q+ R + D +  ++E
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ---QLHRQERDRKFLEEE 1491

Query: 1796 KEALKQEVMSLHKQLQNAGGKSWAPE--IATHPSGLHNQQKRLSWDKLDHLMNEEQQLLW 1853
            ++  +QE     ++ +    +S  PE         LH QQ++  +      + EEQQL  
Sbjct: 1492 QQLRRQE---RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF------LQEEQQLRR 1542

Query: 1854 QENERLQTMVQNTK-AELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL------ 1906
            QE  + +   ++ K  E    R++  + + +   + +K       +   EQE+       
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602

Query: 1907 SLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRST 1966
             L+R+  Q Q  Q   +RK  +   L QE E   L  +   +K ++ + QL   +  +  
Sbjct: 1603 QLRRQEGQQQLRQE-RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661

Query: 1967 ATPSPSPHAWDLQLLQQQACPMVPREQ----FLQLQRQLLQAERINQHLQEELENRTSET 2022
                      + QLLQ+     + R++    F + ++QL + ER  + LQEE + R  E 
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721

Query: 2023 NTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVN-QLKEQLCKNTKADAMVKDLYVE 2081
                  +EQL    E+  +  +++ +  K L +E++  + +EQ  +  + D   +    E
Sbjct: 1722 ERKFREEEQLRQETEQEQLRRQERYR--KILEEEQLRPEREEQQLRRQERDRKFR----E 1775

Query: 2082 NAQLLKALEVTEQRQKTAEKK 2102
              QL +  E  + R + +++K
Sbjct: 1776 EEQLRQEREEQQLRSQESDRK 1796



 Score =  174 bits (442), Expect = 6e-43
 Identities = 338/1561 (21%), Positives = 636/1561 (40%), Gaps = 219/1561 (14%)

Query: 630  EDKVRHYE---KQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAA-- 684
            E+  R +E   +QL+E     +  Q   ++R E E    E +    K E  E + +    
Sbjct: 116  EEDQRRFEPRDRQLEE-----EPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRD 170

Query: 685  -----VLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFE 739
                   +E       R EEE+ Q     E E+   +E+LR +  +EL+ +  + +    
Sbjct: 171  EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230

Query: 740  REREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG 799
            RER   Q   + EE       E +++ + +     E+  L++EE ++      QRELQE 
Sbjct: 231  RER---QDRVFQEE-------EEKEWRKRETVLRKEEEKLQEEEPQR------QRELQEE 274

Query: 800  RE---KMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKS 856
             E   K+E +  RR  Q E Q Q   ++         Q L  +  +E ++ QE++RE++ 
Sbjct: 275  EEQLRKLERQELRRERQEEEQQQQRLRRE--------QQLRRKQEEERREQQEERREQQE 326

Query: 857  QWEFEKDELTQECAEAQELLKET-LKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQL 915
            + E +++   Q+    QE  +E  L+RE+       +  + L +  +E      + R+Q 
Sbjct: 327  RREQQEERREQQLRREQEERREQQLRREQEEE----RREQQLRREQEEERREQQLRREQQ 382

Query: 916  LQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLA-SQRLERLEM 974
            L+  + LR     +Q L  +Q L  +   +RE + R E   Q    +QL   Q  ER E 
Sbjct: 383  LRREQQLRR----EQQLRREQQLRREQQLRREQQLRREQ--QLRREQQLRREQEEERHEQ 436

Query: 975  EHDQERQEMMSKLLAMENIH--KATCETADRERAEMSTEISRLQSKIK-----EMQQATS 1027
            +H+QER+E   K    E     K   ET   E+     ++ R Q + +     ++++   
Sbjct: 437  KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496

Query: 1028 PLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL---LEENGDVLLSLQRAHEQAVKENVKM 1084
                 +   Q+  E+E   +  L   ++ E+L   L     +    +   EQ +K   + 
Sbjct: 497  REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556

Query: 1085 ATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVL 1144
              E  R +QRL++ +         +E   +      E+ +  L++ + +++E   +R  +
Sbjct: 557  RLEQERREQRLKREQ---------EERRDQLLKREEERRQQRLKREQEERLEQRLKREEV 607

Query: 1145 SDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELEN-SEETRTESWELKNQISQL 1203
              LE +E R+        ++R+E + E  +  ++   + E   ++ R E  E + Q  + 
Sbjct: 608  ERLEQEERRE------QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661

Query: 1204 QEQLMMLCADCDRASE---KKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1260
            +E+   L     R  E   ++Q+L  +     ++ +  ERI    PK++   E    E D
Sbjct: 662  EEEEERLEQRLKREHEEERREQELAEE-----EQEQARERIKSRIPKWQWQLES---EAD 713

Query: 1261 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
              Q ++     R  E     +E   +  R + EL+  EE        E+++ + + E + 
Sbjct: 714  ARQSKV-YSRPRKQEGQRRRQEQEEKRRRRESELQWQEE--------ERAHRQQQEEEQR 764

Query: 1321 LNVLVLRLQGKIEKLQESVVQRCDCC--LWEASLENLEIEPDGNILQLNQTLEECVPRVR 1378
             +      Q + E+  E   QR      L E     L  E      Q     EE   + R
Sbjct: 765  RD---FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821

Query: 1379 SVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLL 1438
                   E ++E Q+LE   QL  + +A ++      +Q  QER R Q Q   ++    L
Sbjct: 822  RQRR---EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878

Query: 1439 GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDL 1498
              + K  +H          K  LQE  RK ++   +L ++++ L   E+E+  +      
Sbjct: 879  EEERKRRRHTL------YAKPALQEQLRKEQQ---LLQEEEEELQREEREKRRR------ 923

Query: 1499 QITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKT 1558
                   Q++    R E +  Q+E  +LR E      ++     +        +++ QK 
Sbjct: 924  -------QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR------KDKKLQQKE 970

Query: 1559 ETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQE----KLQELNQRL 1614
            E +  E    ++  E  KK   E +++ ++  L   E  ++  Q  E    K  EL Q  
Sbjct: 971  EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE- 1029

Query: 1615 TEMLCQKEKEPGNSALEEREQ---EKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHI 1671
             E L ++E+E     L+ERE+   E+  L++E E+   +        E E  + + +  +
Sbjct: 1030 EEQLLREERE--KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE-RQYRKEEEL 1086

Query: 1672 VQQENHLLKDELEKMKQLHR---CPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVD 1728
             Q+E  LL++E EK ++  R   C +  + QQ+             E++ L EE      
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQE-------------EEQLLREEREKRRR 1133

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSD 1788
            +  +    E      ++EQ   E      + +L    E+    E+ +Q    Q+ R + +
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQEL----ERQYREEEELQQEEEQLLREEQE 1189

Query: 1789 LRVTQQEKEALKQEVMSLHKQLQNAGGKS--------WAPEIAT-------HPSGLHNQQ 1833
             R  ++E++  ++E +   K+ Q    +         W PE          +  G  N+Q
Sbjct: 1190 KRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQ 1249

Query: 1834 ----------KRLSWDKLDHLMNEEQQL-------LWQENERL---QTMVQNTKAELTHS 1873
                       R S   L HL+ E+Q+         WQ+ +R    +  ++  + +    
Sbjct: 1250 FRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKR 1309

Query: 1874 REKVRQLESNLL--PKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNS 1931
            R++  Q E  LL   + +K           E+E+L  +RE    ++++   +RK  +   
Sbjct: 1310 RDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER--DRKFREEEL 1367

Query: 1932 LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQ--QQACPMV 1989
              QE     LE E   ++Q +  + L E Q LR            D +  +  QQ     
Sbjct: 1368 RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQE 1427

Query: 1990 PREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKL 2049
               +F + ++Q+ + ER  + L+EE + R  E +     +EQL+   EE+ +  +++   
Sbjct: 1428 RDRKFREEEQQVRRQERERKFLEEEQQLR-QERHRKFREEEQLLQEREEQQLHRQER--- 1483

Query: 2050 VKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQ-LLKALEVTEQRQKTAEKKNYLLEE 2108
             ++ L+E      EQ  +  + D   ++  + + +   K LE  +Q  +   ++ +L EE
Sbjct: 1484 DRKFLEE------EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537

Query: 2109 K 2109
            +
Sbjct: 1538 Q 1538



 Score =  112 bits (279), Expect = 5e-24
 Identities = 152/666 (22%), Positives = 284/666 (42%), Gaps = 66/666 (9%)

Query: 370  RHLLERVDQVVREKEKLRSDLD-KAEKLKSLMASEVDDHHAAIERRNEYNLRK-LDEEYK 427
            RH  E  +Q+ RE++K     D K+++ K L+  E ++     E   ++   + L +E +
Sbjct: 1291 RHFPEE-EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349

Query: 428  ERIAALKNELRKEREQIL--QQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN 485
            E+    +   RK RE+ L  Q+ G++ LE EQ + + + E  ++++   L  +E    E 
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER---EQ 1406

Query: 486  ELLENAE-KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 544
            +L ++ + K  E E   ++ +R+ +    E+         +F  +E++L Q R+   R+ 
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466

Query: 545  RVLQDQVDELQSELEE----YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
              L  + +E Q   +E    +  + + LR   ++    E E  S   EPE     EE   
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ--EPERKFLEEE--- 1521

Query: 601  LNMSIEAELVIEQM-KEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 659
                       +Q+ ++Q  R      L+ E ++R  E+         +K +E  + R E
Sbjct: 1522 -----------QQLHRQQRQRKF----LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566

Query: 660  NETHTLEKQISDLKNEIAE--LQGQAAVLKEAHHEATCRHEEEKKQLQV----KLEEEKT 713
             E   L +Q  D K  + E  ++ Q    K    E   R +E ++QL+     K  E++ 
Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626

Query: 714  HLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTS 772
             LQE+   Q H  E   +  + +    R+    Q     + K R   Q L++  ++QL  
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR 1686

Query: 773  LVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESA 832
                    +EE +    E+ ++ LQE ++    E  R+  + E   Q   Q+   R E  
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY 1746

Query: 833  LQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQ 892
             + LE    +  ++ Q+ +R+E+ +   E+++L QE  E Q+L  +   R+      L Q
Sbjct: 1747 RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE-REEQQLRSQESDRKFREEEQLRQ 1805

Query: 893  EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRERE 952
            ER                E QQL     D +   E +Q  L +Q   L+    R+ R  E
Sbjct: 1806 ER----------------EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEE 1849

Query: 953  EVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEI 1012
            +      A+++ + +  + L  E +Q+R++   + L  E+I +   +  + +R     EI
Sbjct: 1850 QF-----ATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR---QQKEEQRHRQVGEI 1901

Query: 1013 SRLQSK 1018
               + K
Sbjct: 1902 KSQEGK 1907



 Score = 32.0 bits (71), Expect = 6.7
 Identities = 48/215 (22%), Positives = 92/215 (42%), Gaps = 16/215 (7%)

Query: 1903 QEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLM---- 1958
            QE+   + E    Q E+ P  R+  +    E+EL     E E   +KQ +L+++      
Sbjct: 115  QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA----EGEEQSEKQERLEQRDRQRRD 170

Query: 1959 -EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL---QLQRQLLQAERINQHLQEE 2014
             E+   R          A + QL   Q+C     E+F    QL+R+ L   R     +++
Sbjct: 171  EELWRQRQEWQEREERRAEEEQL---QSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ 227

Query: 2015 LENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAM 2074
             + R  +    Q  +E+     E  + + E+KL+  +   Q ++ + +EQL K  + + +
Sbjct: 228  QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE-L 286

Query: 2075 VKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEK 2109
             ++   E  Q  +     + R+K  E++    EE+
Sbjct: 287  RRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  206 bits (525), Expect = 2e-52
 Identities = 388/1918 (20%), Positives = 807/1918 (42%), Gaps = 251/1918 (13%)

Query: 309  RILDTWQEE--GIENSQEILKALDFSLDGNINLTELTLALENE---LLVTKNSIHQA--- 360
            +++D  Q+E    E   +IL      ++   N    T+  E E   +L+ K  +  A   
Sbjct: 273  QVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332

Query: 361  -ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEY-- 417
             +  + + E+ HLLE+ +Q  + + +L S     E+           H A +E +  +  
Sbjct: 333  LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQ----------KHKAEMEEKTSHIL 382

Query: 418  NLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSL 477
            +L+K  +E +    ALK++  K    +LQ   +Q ++  Q I++       + D+L    
Sbjct: 383  SLQKTGQELQSACDALKDQNSK----LLQDKNEQAVQSAQTIQQ-------LEDQLQQKS 431

Query: 478  KENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR 537
            KE S+  N L     + A   +  +      + V  E    L          ++R+ ++ 
Sbjct: 432  KEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASL----------QKRVVELE 481

Query: 538  NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPS--EEVEANSGGIEPEHGLGS 595
            NE +    +   +++EL++E E+  +Q  +L    +   +  E  E +   I  +    +
Sbjct: 482  NE-KGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540

Query: 596  EECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMK 655
            EE          + V+E    Q H+++  L LE+++          +  ++  K Q   K
Sbjct: 541  EE--------SGQDVLENTFSQKHKELSVLLLEMKEA---------QEEIAFLKLQLQGK 583

Query: 656  QRHENETHTLE-KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 714
            +  E +   L+ K++  ++ E          L++   +      EE     V+ E+  T 
Sbjct: 584  RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAST- 642

Query: 715  LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 774
                   +H+      ++   A  E     L+S+    +K      ++ Q HQ++L  L 
Sbjct: 643  -------EHQSRTSEEISLNDAGVE-----LKSTKQDGDKSLSAVPDIGQCHQDELERL- 689

Query: 775  EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 834
            +   LE        LE +  + QE  EK   E  +  S +  Q   + +K  +   SA  
Sbjct: 690  KSQILE--------LELNFHKAQEIYEKNLDEKAKEISNLN-QLIEEFKKNADNNSSAFT 740

Query: 835  SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 894
            +L     Q L  ++E     + + + +  +L    AEA+   +   + +     +LT++ 
Sbjct: 741  ALSEERDQLLSQVKELSMVTELRAQVK--QLEMNLAEAERQRRLDYESQTAHDNLLTEQI 798

Query: 895  EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV 954
              L    K    S  V+ + L  +L+D++     Q +L+     +L++     L   E V
Sbjct: 799  HSLSIEAK----SKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERV 854

Query: 955  LCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISR 1014
               +   E+L SQ L + E+E  +  Q ++ K   +E + + T E  D++  E+S  ++ 
Sbjct: 855  RHISSKVEEL-SQALSQKELEITKMDQLLLEKKRDVETLQQ-TIEEKDQQVTEISFSMTE 912

Query: 1015 LQSKIKE--------MQQATSPLSMLQSGCQVIGEEEVEGDGALSL-LQQGEQLLEENGD 1065
               ++ E        ++     L++L S  +   +E+VE D  +S  L+Q    +   G 
Sbjct: 913  KMVQLNEEKFSLGVEIKTLKEQLNLL-SRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971

Query: 1066 VLLS-LQRAHEQAVKENVKMATEIS-------RLQQRLQKLEPGLVMSSCLDEPATEFFG 1117
            +    LQ   +   KEN +   ++         L QR+ +LE  L  ++  DE   E   
Sbjct: 972  ISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEEL--ANLKDESKKEIPL 1029

Query: 1118 NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK--IEESEA 1175
            +  E+ E        K+ +  + + V S  ++ E+    +     V+ Q ++  +EE  A
Sbjct: 1030 SETERGEV----EEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085

Query: 1176 SVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLF--DVSVLKK 1233
            + E F  L        +  +  NQI  LQ ++    A   +      D      V+++K+
Sbjct: 1086 AEEQFQALVKQMNQTLQ--DKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143

Query: 1234 KLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDE 1293
             + +      +S  +K    ++  +   L++E   ++ +  EAL + K +  +    +  
Sbjct: 1144 TVVISPPCTGSSEHWK---PELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200

Query: 1294 LKK-MEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASL 1352
            L++ +++  + +  L++ +DE   ENE +   + +LQ ++ +  +  +   D        
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD------QQ 1254

Query: 1353 ENLEIEPDGNILQLNQTLEECVPRVRSVHH---VIEE--C------KQENQYLEGNTQL- 1400
            E+    P          LEE + +    HH   V+E   C       ++   L+G T + 
Sbjct: 1255 ESCSSTPG---------LEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVA 1305

Query: 1401 -----LEKVKAHEIAWLHGTIQTHQERPRVQNQVI-LEENTTLLGFQD---KHFQHQATI 1451
                 L++++A ++        T  E  +   +V  L+E     G +    K   H+A +
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365

Query: 1452 ----AELELEKTKLQ----ELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCS 1503
                 + +LE ++LQ    E  R+L+ ++  L K   ++S  +KEE++  +   L     
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRELQPKLDELQK---LIS--KKEEDVSYLSGQLS---- 1416

Query: 1504 EMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ 1563
              +++  L + ++E ++QE+ +++   T L  +    + ++  L     EM QK E + +
Sbjct: 1417 --EKEAALTKIQTEIIEQED-LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGE 1473

Query: 1564 ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ--- 1620
            E+ A Q++   L+  +    I  ++   EN  L ++ S  +  ++ L + L ++  Q   
Sbjct: 1474 ESRAKQQIQRKLQAAL----ISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529

Query: 1621 --KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHL 1678
              KEK+     L   ++E+  L  E++R  +++ +L SS E+    +K+    + ++   
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES----LKLALEGLTEDKEK 1585

Query: 1679 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEH 1738
            L  E+E +K   +  + +++Q+K   +    E LL+  E +S E          +  ++H
Sbjct: 1586 LVKEIESLKS-SKIAESTEWQEKHKELQKEYEILLQSYENVSNE----------AERIQH 1634

Query: 1739 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEA 1798
             +  ++QE+   +     L+S     +E  + L++  Q +     +M+   +  QQ+   
Sbjct: 1635 VVEAVRQEK---QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691

Query: 1799 LKQEVMSLHKQLQNAG--GKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1856
            L++E   L  ++  AG   K     + +  + +  + +R+  +     ++++ Q L  E 
Sbjct: 1692 LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEY--ETLSKKFQSLMSEK 1749

Query: 1857 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMN----PTEQEKLSLKRE- 1911
            + L   VQ+ K ++  +  K   LE+     +Q ++   GT +      EQ+ LS+    
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRP 1809

Query: 1912 -CDQFQKEQSPANRKVS-------QMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHL 1963
             C +       AN  VS       ++N+  Q+++ +     GL++++ K  E    +++ 
Sbjct: 1810 TCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENE 1869

Query: 1964 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQ-------AERINQHLQEELE 2016
            ++T     S    +L++LQ++   M    Q  Q+Q +L +       AE     L+E L 
Sbjct: 1870 KNTLLSQISTKDGELKMLQEEVTKMNLLNQ--QIQEELSRVTKLKETAEEEKDDLEERLM 1927

Query: 2017 NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVK 2076
            N+ +E N   GN  Q VT  + +   +E ++K +K+ + E   + ++ + + TK ++ ++
Sbjct: 1928 NQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIR 1987

Query: 2077 DLYVENAQ--------------LLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVRNL 2120
              Y+E  Q              L + L+  +Q  K  +K     +EKI++L   V+ L
Sbjct: 1988 KEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKAL 2045



 Score =  204 bits (518), Expect = 1e-51
 Identities = 418/1972 (21%), Positives = 815/1972 (41%), Gaps = 316/1972 (16%)

Query: 373  LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAA 432
            L++ D+ ++E+ K   +  K +KLK    +++   +  IE         L  E +     
Sbjct: 75   LQQKDEALQEERKAADN--KIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL 132

Query: 433  LKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAE 492
             K++     E++  +  K +L+ ++E+    T +  +    A    ++S    E +   +
Sbjct: 133  SKHDKSSTEEEMEIEKIKHKLQEKEEL--ISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQ 190

Query: 493  KLAEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFLQ----EERLTQMRNEYERQCRV 546
            +L E E   + LQ  L    AE+     +    A F  Q    E+ L Q+  + + +   
Sbjct: 191  QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETE- 249

Query: 547  LQDQVDELQSELEEYRAQ--GRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMS 604
            +Q ++  LQ +LEE+     GR   + L        E  +  +  +      E N L  +
Sbjct: 250  MQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNT 309

Query: 605  IEAE-----LVIEQMK-EQHHRDICC--LRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 656
            +E E     +++E+M+ E   R +    L+ E+   +  +E Q  +     +     ++Q
Sbjct: 310  VETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE-QAGQAQAELESRYSALEQ 368

Query: 657  RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
            +H+ E       I  L+    ELQ     LK+ + +      E+  Q    +++ +  LQ
Sbjct: 369  KHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQ 428

Query: 717  EKLR----LQHEMELKARLTQAQASF-EREREGLQSSAWTEEKVRGLTQELEQFHQEQLT 771
            +K +      + + L+   T +Q SF +   EG Q  A TEE +  L + + +   E+  
Sbjct: 429  QKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQ--AVTEENIASLQKRVVELENEKGA 486

Query: 772  SLVEKHTLEKEELRKE---------LLEKHQRELQEGREKMETE----CNRRTSQIEAQF 818
             L+   ++E EEL+ E         LLE   R  +  RE  E       N+R+S  E   
Sbjct: 487  LLLS--SIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE--- 541

Query: 819  QSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE---L 875
                    E  +  L++   +  +EL  L  + +E + +  F K +L  + AE  +   L
Sbjct: 542  --------ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL 593

Query: 876  LKETLKREKTTSLVLTQEREMLEKTYK-------EHLNSMVVERQQLLQDLEDLRNVSET 928
             ++ +K+ +   +   + +  LE T +       E  +   VE++Q   + +     S T
Sbjct: 594  DQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQ-----SRT 648

Query: 929  QQSL-LSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKL 987
             + + L+D  +ELKS+ +    + ++ L       Q     LERL+           S++
Sbjct: 649  SEEISLNDAGVELKSTKQ----DGDKSLSAVPDIGQCHQDELERLK-----------SQI 693

Query: 988  LAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEG 1046
            L +E N HKA  E  ++   E + EIS L   I+E ++     S   S    + EE  + 
Sbjct: 694  LELELNFHKAQ-EIYEKNLDEKAKEISNLNQLIEEFKKNADNNS---SAFTALSEERDQL 749

Query: 1047 DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGL---- 1102
               +  L    +L  +   + ++L  A  Q   +        + L +++  L        
Sbjct: 750  LSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD 809

Query: 1103 ----VMSSCLDEPATEFFGNTA--EQTEPFLQQNRTKQVEGVTR-RHVLS---------- 1145
                V+ + LD+   +F   +      +  LQ   ++ +EG  R RH+ S          
Sbjct: 810  VKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALS 869

Query: 1146 --DLEDDEVRDLGSTGTSSVQRQEVKIEESEASVE--GFSELENSEETRTESWELKNQIS 1201
              +LE  ++  L       V+  +  IEE +  V    FS  E   +   E + L  +I 
Sbjct: 870  QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929

Query: 1202 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1261
             L+EQL +L     RA E K++ + + + +   LK  +   E SP  ++  E++  E D 
Sbjct: 930  TLKEQLNLL----SRAEEAKKEQVEEDNEVSSGLK--QNYDEMSPAGQISKEELQHEFDL 983

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1321
            L++E    + +   AL N KEL   V RL++EL  +++ ++  + L ++ +  ++E ++ 
Sbjct: 984  LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSET-ERGEVEEDKE 1042

Query: 1322 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1381
            N          E  ++ V  +C     E  L+    E +  +  + + LEE +       
Sbjct: 1043 NK---------EYSEKCVTSKCQEI--EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091

Query: 1382 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ---THQERPRVQNQVILEENTTLL 1438
             ++   KQ NQ L+  T  ++ ++A EI+     IQ   T        + V L + T ++
Sbjct: 1092 ALV---KQMNQTLQDKTNQIDLLQA-EISENQAIIQKLITSNTDASDGDSVALVKETVVI 1147

Query: 1439 G----FQDKHFQHQATIAELELEKTKLQELTRKLKERVT----ILVKQKDVLSHGEKEEE 1490
                    +H++ +     L LEK K ++L +KL+E +T    IL K ++   H    EE
Sbjct: 1148 SPPCTGSSEHWKPELEEKILALEKEK-EQLQKKLQEALTSRKAILKKAQEKERH--LREE 1204

Query: 1491 LKAMMHD---LQITCSEMQQKVELLRYESEKLQ-QENSILRNEITTLNEEDSISNLKLGT 1546
            LK    D   LQ    E  ++ E +  +  +LQ Q    +  ++ + ++++S S+     
Sbjct: 1205 LKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTP--- 1261

Query: 1547 LNGSQEEMWQKTE-----------------TVKQENAAVQ--KMVENLKKQISELKIKNQ 1587
              G +E +++ TE                 +  ++ +A+Q    V  +K Q+ E++ +  
Sbjct: 1262 --GLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV 1319

Query: 1588 QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERC 1647
            +L+L+ +  + + ++  E++ +L +++ +     E E   +   E E    +L+++LE  
Sbjct: 1320 ELELKVSSTTSELTKKSEEVFQLQEQINKQ--GLEIESLKTVSHEAEVHAESLQQKLESS 1377

Query: 1648 KVQSSTL-----------------------VSSLEAELSE-----VKIQTHIVQQENHL- 1678
            ++Q + L                       VS L  +LSE      KIQT I++QE+ + 
Sbjct: 1378 QLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIK 1437

Query: 1679 ---------LKDELEKMKQLH-------RCPD--------LSDFQQKISSVLSYNEKLLK 1714
                      K+  E++KQL        + P+            Q+K+ + L   ++ LK
Sbjct: 1438 ALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALK 1497

Query: 1715 EKEALSEELN---SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNL 1771
            E ++L EEL+     +++L KS      +A ++ +  +   +  ++  +L   QE+   L
Sbjct: 1498 ENKSLQEELSLARGTIERLTKS------LADVESQVSAQNKEKDTVLGRLALLQEERDKL 1551

Query: 1772 -----EDTVQNVNLQMS--RMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT 1824
                    ++N +L  S   +K  L    ++KE L +E+ SL K  + A    W      
Sbjct: 1552 ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL-KSSKIAESTEW------ 1604

Query: 1825 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1884
                   Q+K     K   ++ +  + +  E ER+Q +V+  + E      K+R  E+N 
Sbjct: 1605 -------QEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657

Query: 1885 LPKHQKHLNPSGTM-----------NPTEQEKLSLKRECDQFQKEQSPA--------NRK 1925
                ++       M              +Q+ L L+ E D+ + E  PA           
Sbjct: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717

Query: 1926 VSQMNSLEQELETIHLENEGLKKK-------QVKLDEQLMEMQH------LRSTATPSPS 1972
            +S   S+++ELE + +E E L KK       +  L E++ +++H       +     +  
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777

Query: 1973 PHAWDLQLLQQ--QACPMVPREQ-FLQLQRQLLQAERI-NQHLQEELENRTSETNTPQGN 2028
             H     + ++  Q+ P    EQ  L +  +   +E + +        ++   ++    N
Sbjct: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837

Query: 2029 QEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVE------- 2081
              Q +  ++ER+  +E++ +  K   Q   N+    L + +  D  +K L  E       
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897

Query: 2082 NAQLLKALEVTEQRQKTAEKKNYLLEEKI--------ASLSNIVRNLTPAPL 2125
            N Q+ + L    + ++TAE++   LEE++         S+ N  +++T A +
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQI 1949



 Score =  195 bits (495), Expect = 5e-49
 Identities = 377/1851 (20%), Positives = 777/1851 (41%), Gaps = 247/1851 (13%)

Query: 364  SFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAA-----IERRNEYN 418
            S   EI+ L E+++ + R +E  +  +++  ++ S +    D+   A      E ++E++
Sbjct: 923  SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982

Query: 419  LRKLDEEYKERI--AALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS 476
            L K + E ++R   AAL N     R+++LQ+  +    LE+E+   K E    +  + LS
Sbjct: 983  LLKKENEQRKRKLQAALIN-----RKELLQRVSR----LEEELANLKDES---KKEIPLS 1030

Query: 477  LKENSRLENELLENAEKLAEYENLTNKLQR---NLENVLAEKFGDLD---PSSAEFFLQE 530
              E   +E +  EN E   +   +T+K Q     L+  ++EK  +L        E    E
Sbjct: 1031 ETERGEVEEDK-ENKEYSEKC--VTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087

Query: 531  ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
            E+   +  +  +  +   +Q+D LQ+E+ E +A    +   L  S ++  + +S  +  E
Sbjct: 1088 EQFQALVKQMNQTLQDKTNQIDLLQAEISENQA----IIQKLITSNTDASDGDSVALVKE 1143

Query: 591  HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
              + S  C   +         E  K +    I  L  E E   +  ++ L       KKA
Sbjct: 1144 TVVISPPCTGSS---------EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1194

Query: 651  QENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE---EEKKQLQVK 707
            QE  K+RH             L+ E+ + +     L+E   E +  +E   ++ +QLQ++
Sbjct: 1195 QE--KERH-------------LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ 1239

Query: 708  LEEE------KTHLQE-------------KLRLQHEME--LKARLTQAQASFEREREGLQ 746
            + E        T  QE             K   QH  +  L++ L     S   +   LQ
Sbjct: 1240 VRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQ 1299

Query: 747  SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
                    V  +  +L++   E++  L  K +    EL K+  E  Q + Q  ++ +E E
Sbjct: 1300 GGT----SVAQIKAQLKEIEAEKV-ELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIE 1354

Query: 807  CNRRTSQIEAQFQSDCQKVTERCESALQSLEG--RYRQELKDLQEQQREEKSQWEFEKDE 864
              +  S          Q+  E  +  +  LE     + +L +LQ+   +++    +   +
Sbjct: 1355 SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQ 1414

Query: 865  LTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRN 924
            L+++ A   ++  E +++E     + TQ  EM  K + E +  + VE  ++ Q  E++  
Sbjct: 1415 LSEKEAALTKIQTEIIEQEDLIKALHTQ-LEMQAKEHDERIKQLQVELCEMKQKPEEIGE 1473

Query: 925  VSETQQSL---LSDQILELKSSHKRELREREEVLCQAGASEQLASQR--LERLEMEHDQE 979
             S  +Q +   L   ++  K + K     +EE+    G  E+L      +E      ++E
Sbjct: 1474 ESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE 1533

Query: 980  RQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVI 1039
            +  ++ +L  ++          DR   E  +  S  +S    ++  T     L    + +
Sbjct: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL 1593

Query: 1040 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE 1099
               ++      +  Q+  + L++  ++LL   +++E    E  ++   +  ++Q  Q+L 
Sbjct: 1594 KSSKIAES---TEWQEKHKELQKEYEILL---QSYENVSNEAERIQHVVEAVRQEKQELY 1647

Query: 1100 PGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVR-DLGST 1158
             G + S+  ++  TE     AEQ    +++   K  +   ++ +  + E+D +R ++   
Sbjct: 1648 -GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
            G ++ +  E  +  + +  E   ELE           +K +   L ++   L ++ D  S
Sbjct: 1707 GDTAKECMETLLSSNASMKE---ELER----------VKMEYETLSKKFQSLMSEKDSLS 1753

Query: 1219 EKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDV------SRENDCLQEELRMMETR 1272
            E+ QDL   +     K   LE   +   +  +  E        + E D L    R   + 
Sbjct: 1754 EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813

Query: 1273 YDEALENNKELTAEVFRLQDE----LKKMEEVTETFLSLEKSYDEVK-----IENEELNV 1323
               + ++     ++ F   DE    L++++++ E    LE+   + K     +ENE+  +
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL 1873

Query: 1324 L--VLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1381
            L  +    G+++ LQE V +            NL          LNQ ++E + RV  + 
Sbjct: 1874 LSQISTKDGELKMLQEEVTKM-----------NL----------LNQQIQEELSRVTKLK 1912

Query: 1382 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQER---PRVQNQVILEENTTLL 1438
               EE K +          LE+   +++A L+G+I  + +     +++N+++  E   L 
Sbjct: 1913 ETAEEEKDD----------LEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNL- 1961

Query: 1439 GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDL 1498
                     +  ++ELE EK +L  +  K K    I  +  + +   +KE   K+   +L
Sbjct: 1962 ---------KKCVSELEEEKQQL--VKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010

Query: 1499 QITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKT 1558
            Q    E QQ+V+ L+ +  + Q++ S L   +  L    + S   L     +  +  +  
Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070

Query: 1559 ETVKQENAAVQKMVENLKKQISELKIKNQQL--DLENTELSQKNSQNQEKLQELNQRL-- 1614
            +  + E A+ + ++++ + + + +   N +L  +L++ + S K SQ ++K ++L +RL  
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK-SQMKQKDEDLERRLEQ 2129

Query: 1615 TEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV---QSSTLVSSLEAELSEVKIQTHI 1671
             E    KEK+     L+   +EK +L+E +   +V   +    V  L+  L     Q   
Sbjct: 2130 AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAA 2189

Query: 1672 VQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLA 1731
              +    L+D+ +++       +   +++K S  +   E+ ++ KE   +  +   D+L 
Sbjct: 2190 FTKSMSSLQDDRDRV-----IDEAKKWERKFSDAIQSKEEEIRLKE---DNCSVLKDQLR 2241

Query: 1732 KSSL----LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKS 1787
            + S+    L+  I+ ++ +++ WE   A  + QL   Q+KV    DT+Q  N ++     
Sbjct: 2242 QMSIHMEELKINISRLEHDKQIWE-SKAQTEVQL---QQKVC---DTLQGENKELLSQLE 2294

Query: 1788 DLR----VTQQEKEALKQEVMSLHKQLQN-AGGKSWAPEIATHPSGLHNQQK------RL 1836
            + R     +Q E   L+ E+ SL  QL + +       E   +  G+  QQ+      + 
Sbjct: 2295 ETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKF 2354

Query: 1837 SWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNP-S 1895
            S+++L+  +   ++L  + +E +    Q   + L+   E ++   + L  +H K +    
Sbjct: 2355 SYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE 2414

Query: 1896 GTMNPTEQEKLSLKRECDQFQKEQSPANRK-VSQMNSLEQELETIHLENEGLKKKQVKLD 1954
              ++  E+E + L+ E           N+K V + N L + L+TI  EN    +++ +LD
Sbjct: 2415 NLLSQEEEENIVLEEE-----------NKKAVDKTNQLMETLKTIKKEN---IQQKAQLD 2460

Query: 1955 EQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE 2014
              +  M  L++        +    QL ++    ++ ++Q +Q      +A   N  L+EE
Sbjct: 2461 SFVKSMSSLQNDRDRIVGDYQ---QLEERHLSIILEKDQLIQ------EAAAENNKLKEE 2511

Query: 2015 ---LENRTSETNTPQGNQE-QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTK 2070
               L +   + N+     + +L+   E+    +  K    K+LL+ ++ Q KE   K  K
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAK 2571

Query: 2071 ADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVRNLT 2121
             +  +K+    N  L ++    ++ ++   K+   +E    S+S + R +T
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQEEKQDLSKE---IESLKVSISQLTRQVT 2619



 Score =  184 bits (468), Expect = 6e-46
 Identities = 403/1953 (20%), Positives = 798/1953 (40%), Gaps = 334/1953 (17%)

Query: 403  EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKA 462
            E+++   A+E+  E   +KL E    R A LK    KER             L +E+++ 
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH------------LREELKQQ 1208

Query: 463  KTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS 522
            K + N ++++     KEN  + ++L +   ++   E++  KL    +         L+  
Sbjct: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQL--QIQVRESIDGKLPSTDQQESCSSTPGLEEP 1266

Query: 523  SAEFFLQEERLTQMRNE---------YERQCRVLQD--QVDELQSELEEYRAQGRVLRLP 571
               F   E+  TQ   E         +      LQ    V +++++L+E  A+   L L 
Sbjct: 1267 L--FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELK 1324

Query: 572  LKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDI------CCL 625
            + ++ SE  + +    + +     E+ N   + IE+   +    E H   +        L
Sbjct: 1325 VSSTTSELTKKSEEVFQLQ-----EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQL 1379

Query: 626  RLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 685
            ++   + +R  + +LDE      K +E++      +    E  ++ ++ EI E +     
Sbjct: 1380 QIAGLEHLRELQPKLDELQKLISKKEEDVSYL-SGQLSEKEAALTKIQTEIIEQEDLIKA 1438

Query: 686  LKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA-QASFEREREG 744
            L          H+E  KQLQV+L E K   +E   +  E   K ++ +  QA+    +E 
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQKPEE---IGEESRAKQQIQRKLQAALISRKEA 1495

Query: 745  LQSSAWTEEKV---RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE 801
            L+ +   +E++   RG  + L +   + + S V     EK+ +   L       LQE R+
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLAD-VESQVSAQNKEKDTVLGRLAL-----LQEERD 1549

Query: 802  KMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG------RYRQELKDLQEQQREEK 855
            K+ TE +R  S +E Q       ++  CES   +LEG      +  +E++ L+  +  E 
Sbjct: 1550 KLITEMDR--SLLENQ------SLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAES 1601

Query: 856  SQWEFEKDELTQE----CAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE 911
            ++W+ +  EL +E        + +  E  + +     V  +++E+  K      N    E
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661

Query: 912  RQ--QLLQDLEDLRNVSETQQSLLSDQILELKSSHKR----------ELREREEVLCQAG 959
            +Q  +  Q++E+++            +ILEL+  + R            +E  E L  + 
Sbjct: 1662 KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721

Query: 960  ASEQLASQRLERLEMEHD---QERQEMMSKLLAME------------NIHK-ATCETADR 1003
            AS +   + LER++ME++   ++ Q +MS+  ++             N+ K A  E  ++
Sbjct: 1722 ASMK---EELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEK 1778

Query: 1004 ERAEMSTEISRLQSKIKEMQQATSPLSM------------LQSGCQVIGEEEVEGDGALS 1051
               + +      QS   E ++  S LSM             +S    + ++    D   +
Sbjct: 1779 HDNQTNVTEEGTQSIPGETEEQDS-LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837

Query: 1052 LLQQGEQLLEENGDVLLSLQRAHE-QAVKENVK--MATEISRLQQRLQKLEPGLVMSSCL 1108
             LQQ +QL E    +    Q+  E     EN K  + ++IS     L+ L+  +   + L
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897

Query: 1109 DEPATEFFGN------TAEQTEPFLQQNRTKQV-----------EGVTRRHVLSDLEDDE 1151
            ++   E          TAE+ +  L++    Q+           + VT   + ++L + E
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957

Query: 1152 VRDLGSTGTSSVQRQEVKIEE-----SEASVEGFSELENSEE---TRTESWELKNQISQL 1203
            +++L    +   + ++  ++E     SE   E   +++ +++    ++ + EL+  + + 
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEK 2017

Query: 1204 QEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK---------------- 1247
            Q+++  L  DC R  EK       +S L++ +K LE +   S K                
Sbjct: 2018 QQEVKQLQKDCIRYQEK-------ISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070

Query: 1248 ---------YKLLYEDVSREND-CLQEELRMMETRYDEALENNKELTAEVFRLQDE--LK 1295
                     +K+L +D   E    L + L++ +      L++NKE      + +DE   +
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKE-----LQSNKESVKSQMKQKDEDLER 2125

Query: 1296 KMEEVTETFLSLEKSYDE---------VKIENE--ELNVLVLRLQGKIEKLQESVVQRC- 1343
            ++E+  E  L  +K+  E         V +E    E+ V + +   ++++LQE++     
Sbjct: 2126 RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL-- 1401
                +  S+ +L+ + D       + ++E     R     I+  ++E +  E N  +L  
Sbjct: 2186 QLAAFTKSMSSLQDDRD-------RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2238

Query: 1402 ---------EKVKA------HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKH 1444
                     E++K       H+        QT  +  +     +  EN  LL    + +H
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298

Query: 1445 FQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSE 1504
              H +     + E  KL+   + LK+++T      D+ +  EK +E K    +L+    +
Sbjct: 2299 LYHSS-----QNELAKLESELKSLKDQLT------DLSNSLEKCKEQKG---NLEGIIRQ 2344

Query: 1505 MQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQE 1564
             +  ++  ++  E+L+ +    R   + L+EE ++   K+ +L   +EE  Q        
Sbjct: 2345 QEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQ-------- 2396

Query: 1565 NAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKE 1624
              A+ ++ +   K+I EL+    Q + EN  L ++N +  +K  +L + L  +  +KE  
Sbjct: 2397 -VAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTI--KKENI 2453

Query: 1625 PGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKD 1681
               + L+   +   +L+ + +R       L    E  LS +  +  ++Q+   EN+ LK+
Sbjct: 2454 QQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE---ERHLSIILEKDQLIQEAAAENNKLKE 2510

Query: 1682 ELEKMKQLHRCPDLSDFQQKISS-VLSYNEKL---LKEKEALSEELNSCVDKLAKSSLLE 1737
            E+  ++      DL+    K+ + ++ Y E L   +  K++  ++L     +L ++  LE
Sbjct: 2511 EIRGLRS--HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV--QLQQNKELE 2566

Query: 1738 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE-- 1795
            ++ A ++++ K  E  +  L+    A QE+ Q+L   ++++ + +S++   +   Q+E  
Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626

Query: 1796 ----KEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQL 1851
                   LK +   +H+   +A   S    IA     L   QK  +       + E +  
Sbjct: 2627 LGLYHAQLKVKEEEVHR--LSALFSSSQKRIAELEEELVCVQKEAA-----KKVGEIEDK 2679

Query: 1852 LWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE 1911
            L +E + L       + E   + E+V +L  +L+   QK L  +        +  S  R 
Sbjct: 2680 LKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRS 2739

Query: 1912 CDQFQKEQSPANRKVSQM-NSLEQEL-ETIHLENEGLKKKQVKLDEQLMEMQHLRSTATP 1969
                Q  +  AN ++ ++    +  L E   L+ +GL  ++   D  L E     ++   
Sbjct: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE--RDALLSETAFSMNSTEE 2797

Query: 1970 SPSPHAWDLQLLQQQACPMVPREQFLQLQRQL----------------LQAERINQHLQE 2013
            +   H   L+ L QQ   +   EQ L L  QL                LQ ER   HL  
Sbjct: 2798 NSLSH---LEKLNQQL--LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER--DHLWN 2850

Query: 2014 ELE----------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQE--KVNQ- 2060
            ELE             ++ +T     + L   M     + ++ LK +K L Q+  ++NQ 
Sbjct: 2851 ELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE 2910

Query: 2061 ------LKEQLCK---NTKA-DAMVKDLYVENAQLLKALEVTEQRQKTAE------KKNY 2104
                  LK QL +    TKA   M ++L  EN      L      + + E      K+ Y
Sbjct: 2911 ITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQY 2970

Query: 2105 LL-----EEKIASLSNIVRNLTPAPLTSTPPLR 2132
            L+     +++++ L N++R L  +  + T PL+
Sbjct: 2971 LMAISDKDQQLSHLQNLIRELRSSS-SQTQPLK 3002



 Score =  153 bits (386), Expect = 2e-36
 Identities = 304/1467 (20%), Positives = 622/1467 (42%), Gaps = 246/1467 (16%)

Query: 341  ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM 400
            E +  LENE    KN++  + +++   E++ L E V ++    ++++ +L +  KLK   
Sbjct: 1861 EFSQTLENE----KNTL-LSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETA 1915

Query: 401  ASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIE 460
              E DD               L+E    ++A L   +    + +     K  L LE E++
Sbjct: 1916 EEEKDD---------------LEERLMNQLAELNGSIGNYCQDVTDAQIKNEL-LESEMK 1959

Query: 461  KAKTEENYIRDRLALSLKENSRLENELL-ENAEKL--AEYENLTNKLQRNLENVLAEKFG 517
              K   + + +     +KE +++E+E+  E  EK+  A+ E       + L+ +L EK  
Sbjct: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ 2019

Query: 518  DLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELE----------EYRAQGRV 567
            ++     +    +E+++ +    ER  + L+    E Q +LE          E+R + + 
Sbjct: 2020 EVKQLQKDCIRYQEKISAL----ERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQA 2075

Query: 568  ----LRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNM----SIEAELVIEQMKEQHH 619
                 ++ L ++ SE     +  ++ +  L S + +  +       + E  +EQ +E+H 
Sbjct: 2076 ELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHL 2135

Query: 620  RDICCLRLELEDKVR---HYEKQLDETVVSCKKAQENMKQRHENETHTLE------KQIS 670
            ++   ++ +L+   R   H E+ + E  V+  K  + ++Q  EN   T+       K +S
Sbjct: 2136 KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMS 2195

Query: 671  DLKNEIAELQGQAAVLKEAHHEATCRHEEE--------------KKQLQVKLEEEKTHLQ 716
             L+++   +  +A   +    +A    EEE               +Q+ + +EE K ++ 
Sbjct: 2196 SLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINIS 2255

Query: 717  EKLRLQHEMELKARLTQAQASFERE---------REGLQSSAWTEEKVRGLTQELEQFHQ 767
               RL+H+ ++     Q +   +++         +E L     T         EL +   
Sbjct: 2256 ---RLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLES 2312

Query: 768  E------QLTSLVEKHTLEKEELRKELLE----KHQRELQEGR---EKMETECNRR---T 811
            E      QLT L   ++LEK + +K  LE    + + ++Q  +   E++ET+       T
Sbjct: 2313 ELKSLKDQLTDL--SNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELT 2370

Query: 812  SQIEAQFQSDCQKVT-------ERCESALQSLEGRYRQELKDLQE---QQREEKSQWEFE 861
            S++  +     QK+        E  + A+  L  ++ +E+K+L+    Q+ EE    E E
Sbjct: 2371 SRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEE 2430

Query: 862  KDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLED 921
              +   +  +  E LK T+K+E        Q++  L+   K  ++S+  +R +++ D + 
Sbjct: 2431 NKKAVDKTNQLMETLK-TIKKENI------QQKAQLDSFVKS-MSSLQNDRDRIVGDYQQ 2482

Query: 922  LRNVSETQQSLL--SDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQE 979
            L    E   S++   DQ+++  ++   +L+E  E+       + L S+   +L+ E  Q 
Sbjct: 2483 LE---ERHLSIILEKDQLIQEAAAENNKLKE--EIRGLRSHMDDLNSENA-KLDAELIQY 2536

Query: 980  RQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL----SMLQSG 1035
            R+++   +   ++  K   E   ++  E+  + ++L+ K+KE ++A   L    + LQ  
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596

Query: 1036 CQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENV-KMATEISRLQQR 1094
             Q + +E      ++S L +    L+E G   L L  A  +  +E V +++   S  Q+R
Sbjct: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGT--LGLYHAQLKVKEEEVHRLSALFSSSQKR 2654

Query: 1095 LQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRD 1154
            + +LE  LV   C+ + A +  G   ++ +  L+        G+ R    ++  ++ V +
Sbjct: 2655 IAELEEELV---CVQKEAAKKVGEIEDKLKKELKH--LHHDAGIMRNE--TETAEERVAE 2707

Query: 1155 LGSTGTSSVQRQEVKIEESE---ASVEGFSELENSEETRTESWELKNQISQLQEQLMMLC 1211
            L        Q+  +  +E++   A ++ F    +S         L+N      E+L    
Sbjct: 2708 LARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS---------LQNSRDHANEEL---- 2754

Query: 1212 ADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMET 1271
               D    K    L +++ LK++  +L R  +A     LL E     N   +  L  +E 
Sbjct: 2755 ---DELKRKYDASLKELAQLKEQ-GLLNRERDA-----LLSETAFSMNSTEENSLSHLEK 2805

Query: 1272 RYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGK 1331
               + L  +++L     +L+D   +++  ++   SL+   D               L  +
Sbjct: 2806 LNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDH--------------LWNE 2851

Query: 1332 IEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH-HVIEECKQ- 1389
            +EK ++S          E   +    +P  +  ++ Q+L++ +  +++    +++E K  
Sbjct: 2852 LEKFRKS----------EEGKQRSAAQPSTSPAEV-QSLKKAMSSLQNDRDRLLKELKNL 2900

Query: 1390 ENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQA 1449
            + QYL+ N ++ E      +  L   +Q +Q++ +   Q++ EE    L  ++  +QH+ 
Sbjct: 2901 QQQYLQINQEITE------LHPLKAQLQEYQDKTKAF-QIMQEE----LRQENLSWQHE- 2948

Query: 1450 TIAELELEKTKLQELTRKLKERVTILVKQKDV-LSHGEKEEELKAMMHDLQITCSEMQQ- 1507
             + +L +EK+  +   R++KE+  + +  KD  LSH      L+ ++ +L+ + S+ Q  
Sbjct: 2949 -LHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSH------LQNLIRELRSSSSQTQPL 3001

Query: 1508 KVELLRYES----------EKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1557
            KV+  R  S          + L  E  +LR ++    +E     L++  LN +  ++ ++
Sbjct: 3002 KVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEE 3061

Query: 1558 TETVK-QENAAVQKMVEN-------------LKKQISELKIKNQQLDLENTELSQKN--- 1600
              T+  Q     Q + EN             L+KQ+ EL+     +D+      +KN   
Sbjct: 3062 KNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVH 3121

Query: 1601 -SQNQEKLQELNQRLTE---MLCQKEKEPG--NSALEEREQEKFNLKEELERCKVQSSTL 1654
               + E+L+E  Q  +E    LC   +E       LEE   ++   +  L   + Q   L
Sbjct: 3122 RKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRL 3181

Query: 1655 VSSLEAELSEVKIQTHIVQQENHLLKD 1681
              S E + S   I      QE  LL D
Sbjct: 3182 EHS-EWDSSRTPIIGSCGTQEQALLID 3207



 Score =  101 bits (252), Expect = 7e-21
 Identities = 174/849 (20%), Positives = 373/849 (43%), Gaps = 100/849 (11%)

Query: 315  QEEGIENSQEILKALDFSLDGNINLT-----ELTLALEN--ELLVTKNSIHQAALASFKA 367
            QE  I+NS+   + L+  L  +  LT     E+ +  +    LL  K    Q A+A  + 
Sbjct: 2345 QEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQ 2404

Query: 368  EIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYK 427
            +    ++ ++ ++ ++E+    L++  K      +++ +    I++ N     +LD   K
Sbjct: 2405 QHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464

Query: 428  ERIAALKNELRK-----------------EREQILQQAGKQRLELEQEIEKAKTEENYIR 470
              +++L+N+  +                 E++Q++Q+A  +  +L++EI   ++  + + 
Sbjct: 2465 S-MSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLN 2523

Query: 471  DRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQE 530
                    EN++L+ EL++  E L +   + +  Q+ L  V  ++  +L+   A+   + 
Sbjct: 2524 S-------ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKL 2576

Query: 531  ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
            +   +   +  R    LQ++  +L  E+E  +    + +L  + +  +E E   G    +
Sbjct: 2577 KESEEANEDLRRSFNALQEEKQDLSKEIESLKVS--ISQLTRQVTALQE-EGTLGLYHAQ 2633

Query: 591  HGLGSEECNPLN-MSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKK 649
              +  EE + L+ +   ++  I +++E    ++ C++ E   KV   E +L + +     
Sbjct: 2634 LKVKEEEVHRLSALFSSSQKRIAELEE----ELVCVQKEAAKKVGEIEDKLKKELKHLHH 2689

Query: 650  AQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
                M+    NET T E+++++L  ++ E++ +  ++ + +   T + +   + +   L+
Sbjct: 2690 DAGIMR----NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS-SLQ 2744

Query: 710  EEKTHLQE---KLRLQHEMELK--ARLTQAQASFEREREGLQSSA-----WTEEKVRGLT 759
              + H  E   +L+ +++  LK  A+L + Q    RER+ L S        TEE      
Sbjct: 2745 NSRDHANEELDELKRKYDASLKELAQLKE-QGLLNRERDALLSETAFSMNSTEENSLSHL 2803

Query: 760  QELEQ---FHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEA 816
            ++L Q      EQL  L  +  LE    + +   K    LQ  R+ +  E  +     E 
Sbjct: 2804 EKLNQQLLSKDEQLLHLSSQ--LEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEG 2861

Query: 817  QFQSDCQKVTERCE--------SALQSLEGRYRQELKDLQEQQ---REEKSQWEFEKDEL 865
            + +S  Q  T   E        S+LQ+   R  +ELK+LQ+Q     +E ++    K +L
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQL 2921

Query: 866  T--QECAEAQELLKETLKREKTT-SLVLTQER------EMLEKTYKEHLNSMVVERQQLL 916
               Q+  +A ++++E L++E  +    L Q R      E+ E+  KE     + ++ Q L
Sbjct: 2922 QEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQL 2981

Query: 917  QDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 976
              L++L  + E + S  S Q   LK  ++R+     E       S+ L  +  E L  + 
Sbjct: 2982 SHLQNL--IRELRSS--SSQTQPLKVQYQRQ--ASPETSASPDGSQNLVYE-TELLRTQL 3034

Query: 977  DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGC 1036
            +   +E+  K L ++ ++    +  + E+  +S ++      ++E QQ       L + C
Sbjct: 3035 NDSLKEIHQKELRIQQLNSNFSQLLE-EKNTLSIQLCDTSQSLRENQQHYGD---LLNHC 3090

Query: 1037 QVIGEEEVE-GDGALSLLQQGEQLLEENG-------DVLLSLQRAHEQAVKENVKMATEI 1088
             V+ ++  E   G L++        E+NG       + L   Q++  +A ++      E+
Sbjct: 3091 AVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEV 3150

Query: 1089 SRLQQRLQK 1097
            + L++ L++
Sbjct: 3151 NELRKLLEE 3159


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  206 bits (524), Expect = 2e-52
 Identities = 371/1710 (21%), Positives = 712/1710 (41%), Gaps = 261/1710 (15%)

Query: 387  RSDLDKAEKLKSLMASEVDDHHAAIERR-NEYNLRKLDEEYKERIAALKNEL------RK 439
            + DL K  K + ++  +       +E+   E   + + E   + I AL   L      + 
Sbjct: 27   KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86

Query: 440  EREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS----LKENSRLENELLENAEKLA 495
            E EQ      K+ ++++QE+E + T+       L  S    +KE   L+NEL+    K +
Sbjct: 87   ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146

Query: 496  EYE-NLTNKLQR--NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 552
            E + NL  +L+   N +  L+E+    + S       +E + ++R  +E Q   LQ Q+D
Sbjct: 147  EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206

Query: 553  ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612
                E +E   Q       L+N     +EANS   +               S++ EL+  
Sbjct: 207  ATTDEKKETVTQ-------LQNI----IEANSQHYQKNIN-----------SLQEELL-- 242

Query: 613  QMKEQHHRDICCLRLELEDKVRHYEKQL-------DETVVSCKKAQENMKQRHENETHTL 665
            Q+K  H  ++  L  ++E   + +E ++       +  V  C+ +++N+++++E E   L
Sbjct: 243  QLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL 302

Query: 666  EKQISDLK--NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQH 723
             K  S+    N+I  +  Q     E       +H E+  +   +LE + + L++++   +
Sbjct: 303  RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK---ELESQHSILKDEVTYMN 359

Query: 724  EMELKARL--TQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 781
             ++LK  +     +  F  ERE L      E K+  L        +E+   ++EK   E 
Sbjct: 360  NLKLKLEMDAQHIKDEFFHEREDL------EFKINELL-----LAKEEQGCVIEKLKSEL 408

Query: 782  EELRKEL---LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 838
              L K+    +E+H RE+Q  +E+ + E     S++   F SD +K        +Q L  
Sbjct: 409  AGLNKQFCYTVEQHNREVQSLKEQHQKE----ISELNETFLSDSEKEKLTLMFEIQGL-- 462

Query: 839  RYRQELKDLQEQQREEKSQWEFEKD--ELTQ-ECAEAQELLK---ETLKREKTTSLVLTQ 892
              +++ ++LQ++++E    +E  ++  E+ Q E  E+   +    E++K+++ + +   Q
Sbjct: 463  --KEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520

Query: 893  EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL--ELKSSHKRELRE 950
            ++          L +   E+  LL+ +  L+  +E    LLS Q L  EL+++ K  L+E
Sbjct: 521  QK----------LRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIK-NLQE 566

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL----AMENIHKATCETADRERA 1006
            +  V   + +      + LE       +E+ + ++KL      M+N HK  CE  +R   
Sbjct: 567  KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK-KCEREERLIL 625

Query: 1007 EMSTEISR------------------LQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGD 1047
            E+  ++ +                  L+  +KE  Q    L  L    +V+ E+ EV   
Sbjct: 626  ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685

Query: 1048 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL--EPGLVMS 1105
               SL ++  +L  E   +   L+    Q  KE+V +   I++L+++LQ +  E   +  
Sbjct: 686  EVKSLYEENNKLSSEKKQLSRDLEVFLSQ--KEDVILKEHITQLEKKLQLMVEEQDNLNK 743

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
               +E   + F  T  Q   FL++  ++  E           E D V  L + G S  + 
Sbjct: 744  LLENEQVQKLFVKT--QLYGFLKEMGSEVSE--------DSEEKDVVNVLQAVGESLAKI 793

Query: 1166 QEVKIEESEASVEGFSELEN-----SEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1220
             E K   +    E   ELE       EE+  +  ELK+ +   +++ ++L  + +    +
Sbjct: 794  NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853

Query: 1221 KQDLLFDVSVLKKK-----------LKMLERIPEASPKYKLLYEDVS---RENDCLQEEL 1266
            K+ L  D+  +K             L  +E + +   K ++  E      +E++ L+  L
Sbjct: 854  KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913

Query: 1267 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIEN-------- 1318
               E R         +  AE+  L+D L K   V    LS  K  +E KIEN        
Sbjct: 914  EQKELR---------DRRAELILLKDSLAKSPSVKNDPLSSVKELEE-KIENLEKECKEK 963

Query: 1319 -EELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRV 1377
             E++N + L      ++L  S   R +    +  LE+L  E D    QL+ ++ + +   
Sbjct: 964  EEKINKIKLVAVKAKKELDSS---RKETQTVKEELESLRSEKD----QLSASMRDLIQGA 1016

Query: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI------- 1430
             S  +++ E +++++ L+     +EK +A+        +        +Q + I       
Sbjct: 1017 ESYKNLLLEYEKQSEQLD-----VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071

Query: 1431 ------LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSH 1484
                  L+ N  LL  Q    Q    + + ELE  KLQ+  +K+KE  T + + +++   
Sbjct: 1072 LARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK-EQKIKEHATTVNELEELQVQ 1130

Query: 1485 GEKE-EELKAMMHDLQITCSEMQQ----KVELLRYE--SEKLQQENSILRNEITTLNEED 1537
             +KE ++L+  M +L++   + QQ     +E+  YE   ++L Q+ +   N+I  L +E 
Sbjct: 1131 LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEI 1190

Query: 1538 SISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1597
             I   K  TL      +    +  +++N  +++++   KK++++ K       +    L 
Sbjct: 1191 KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLK 1250

Query: 1598 QKNSQNQEKLQELNQRLTEMLCQKEK---------EPGNSALEEREQEKFNLKEELERCK 1648
             +   +Q++++    +L E+  +K K         E     L   +Q    L+EE    K
Sbjct: 1251 GELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAK 1310

Query: 1649 VQSSTLVSSLEAELSEVKIQTHIVQQENHLL--------KDELEKMKQL--HRCPDLSDF 1698
             + +T+ S  E E  +V++   + QQ+N  +        K E E ++ L       L D 
Sbjct: 1311 AEQATVTS--EFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDS 1368

Query: 1699 QQKISSVLSYNEKLLKEKEALSEELNSCV-DKLAKSSLLEHRIATMKQEQKSWEHQSASL 1757
            Q  +   +S  + L  E + L E  N  + + ++K + L  ++ +++ E    + +    
Sbjct: 1369 QNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQT 1428

Query: 1758 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1817
             SQL +  E ++N      +   Q+  ++ + R T    E L+Q++  +  QL     + 
Sbjct: 1429 VSQLTSQNEVLRN------SFRDQVRHLQEEHRKT---VETLQQQLSKMEAQLFQLKNEP 1479

Query: 1818 WAPEIATHPSGLHNQQKRLSWD--KLD-HLMNEEQQLLWQENERLQTMVQNTKAELTHSR 1874
                  +    L N ++R + D   LD H +  E      E E ++T    T  E   S 
Sbjct: 1480 TTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE------EGEGMET----TDTESVSSA 1529

Query: 1875 EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQ 1934
                Q    LL   +  L P        +E+L  K          S   +    +N L +
Sbjct: 1530 STYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQK---------LSSTTKSADHLNGLLR 1580

Query: 1935 ELE---TIHLENEGLKKKQVKLDEQLMEMQ 1961
            E E    I +E   L K +++  E+  E +
Sbjct: 1581 ETEATNAILMEQIKLLKSEIRRLERNQERE 1610



 Score =  125 bits (314), Expect = 4e-28
 Identities = 243/1211 (20%), Positives = 494/1211 (40%), Gaps = 193/1211 (15%)

Query: 1075 EQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQ 1134
            E  +K   K    I + + R  +LE  +       +P TE  G+  +     L     ++
Sbjct: 28   EDLIKFAKKQMMLIQKAKSRCTELEKEI--EELRSKPVTEGTGDIIKALTERLDALLLEK 85

Query: 1135 VEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEE----TR 1190
             E  T +  LS L+ + ++       S  +  +   E  ++ +    E+EN +      R
Sbjct: 86   AE--TEQQCLS-LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVR 142

Query: 1191 TESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1250
            ++  E K  + +  E+ M      +   E  + L F  +      K+ E I +  P ++ 
Sbjct: 143  SKYSEDKANLQKQLEEAM------NTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEE 196

Query: 1251 LYEDVSRENDCLQEELRMMETRYDEALE-NNKELTAEVFRLQDELKKM-----EEVTETF 1304
                + ++ D   +E +   T+    +E N++     +  LQ+EL ++     EEV E  
Sbjct: 197  QILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELM 256

Query: 1305 LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNI- 1363
              +E S  E + E  +LN L   L  + E  ++++ ++ +C L            D  I 
Sbjct: 257  CQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQIC 316

Query: 1364 ---LQLNQTLEECV-PRVRSVHHVIEECKQENQYLEGNTQLLEKVKAH-EIAWLHGTIQT 1418
               LQ N  +E+ V  +V+ +   ++E + ++  L+     +  +K   E+   H   + 
Sbjct: 317  SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF 376

Query: 1419 HQERPRVQNQV------------ILEENTTLLGFQDKHF----------------QHQAT 1450
              ER  ++ ++            ++E+  + L   +K F                QHQ  
Sbjct: 377  FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE 436

Query: 1451 IAEL--------ELEKTKLQELTRKLKERVTILVKQK--------------DVL------ 1482
            I+EL        E EK  L    + LKE+   L ++K              ++L      
Sbjct: 437  ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGE 496

Query: 1483 SHGEKEEELKAMMHDLQITCSEMQQK--------------VELLRYESEKLQQENSI--- 1525
            S G+  +E ++M         E+QQK              V  L+ E+EKL  +  +   
Sbjct: 497  SAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE 556

Query: 1526 LRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIK 1585
            L N I  L E++ +  L L   +   +E+  K  ++ +E       ++N  +++     K
Sbjct: 557  LENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKK 616

Query: 1586 NQQLDLENTELSQK-------NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKF 1638
             ++ +    EL +K       NS+ ++K+ EL   L E L  KEK+  +  LE+   +  
Sbjct: 617  CEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETL--KEKDQNDQKLEKLMVQMK 674

Query: 1639 NLKEELERCKVQSSTLVSSLEAELSEVK-----IQTHIVQQENHLLKD---ELEKMKQLH 1690
             L E+ E    +  +L        SE K     ++  + Q+E+ +LK+   +LEK  QL 
Sbjct: 675  VLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL- 733

Query: 1691 RCPDLSDFQQKISSVLSYNEKLLK-----EKEALSEELNSCVDKLAKSSLLEHRIATMKQ 1745
                + + Q  ++ +L  NE++ K     +     +E+ S V + ++   + + +  + +
Sbjct: 734  ----MVEEQDNLNKLLE-NEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGE 788

Query: 1746 EQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN----LQMSRMKSDLRVTQQEKEALKQ 1801
                   +  +L  Q     EKV  LE  ++ +     +Q   +KS LR  +QEK  L++
Sbjct: 789  SLAKINEEKCNLAFQ---RDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRK 845

Query: 1802 EVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH------LMNEEQQLLWQE 1855
            E+  +  + +         + A   + L NQ   +  +++        + NE+++   +E
Sbjct: 846  ELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKE 905

Query: 1856 NERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQF 1915
            +E L+ +++  + EL   R ++  L+ +L        +P  ++   E++  +L++EC + 
Sbjct: 906  HENLKPLLE--QKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEK 963

Query: 1916 Q-------------KEQSPANRKVSQMNSLEQELETIHLENEGL---------------- 1946
            +             K++  ++RK +Q  ++++ELE++  E + L                
Sbjct: 964  EEKINKIKLVAVKAKKELDSSRKETQ--TVKEELESLRSEKDQLSASMRDLIQGAESYKN 1021

Query: 1947 -----KKKQVKLD---EQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQ-- 1996
                 +K+  +LD   E+    +H     T          + +      ++ R + LQ  
Sbjct: 1022 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSN 1081

Query: 1997 ---LQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRL 2053
               L+ Q+L+ +R    + +ELE    +           V  +EE  ++++++ K +++ 
Sbjct: 1082 AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKT 1141

Query: 2054 LQE----KVNQLKEQLCKNTKAD--AMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLE 2107
            +QE    K +  +  L     AD   ++K+L  +       +E  EQ  K  ++K   L+
Sbjct: 1142 MQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQ 1201

Query: 2108 EKIASLSNIVR 2118
            E+I SL + V+
Sbjct: 1202 EEITSLQSSVQ 1212



 Score =  122 bits (307), Expect = 3e-27
 Identities = 260/1339 (19%), Positives = 537/1339 (40%), Gaps = 180/1339 (13%)

Query: 348  NELLVTKNSIHQAALASFKAEIRHLLER----VDQVVREKEKLRSD------------LD 391
            NELL+ K       +   K+E+  L ++    V+Q  RE + L+              L 
Sbjct: 388  NELLLAKEE-QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLS 446

Query: 392  KAEKLKSLMASEVDDHHAAIERR---------NEYNLRKLDEEYKERIAALKNELRKERE 442
             +EK K  +  E+       E           N  +LR++ E  +  +     ++ +E E
Sbjct: 447  DSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE 506

Query: 443  QILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTN 502
             + QQ      EL+Q++  A TE++ + + +     EN +    LL   E + E EN   
Sbjct: 507  SMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEK----LLSQQELVPELENTIK 562

Query: 503  KLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR 562
             LQ     V        D    E   +   LT+ ++++  + +   +++D    + E   
Sbjct: 563  NLQEK-NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE 621

Query: 563  AQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDI 622
                 L L L     + ++ NS   E E     ++ N L   +E     E +KE+   D 
Sbjct: 622  R----LILELGKKVEQTIQYNS---ELE-----QKVNELTGGLE-----ETLKEKDQNDQ 664

Query: 623  CCLRLELEDKVRHYEKQLDETVVSC------KKAQENMKQRHENETHTLEKQISDLKNEI 676
               +L ++ KV   +K++    V        K + E  +   + E    +K+   LK  I
Sbjct: 665  KLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHI 724

Query: 677  AELQGQAAVLKEAHHEATCRHEEE-------KKQLQVKLEEEKTHLQEKLRLQHEMELKA 729
             +L+ +  ++ E         E E       K QL   L+E  + + E    +  + +  
Sbjct: 725  TQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQ 784

Query: 730  RLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE-KHTLEKEELRKEL 788
             + ++ A    E+  L  +   +EKV  L +E++   +E +    E K  L   E  K L
Sbjct: 785  AVGESLAKINEEKCNL--AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL 842

Query: 789  LEKHQRELQEGREKMETE------CNRRTSQIEAQFQSDCQKVTERCESALQSLEG---- 838
            L K   E+Q  +E ++++       N +T           ++V++ C  +    E     
Sbjct: 843  LRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCF 902

Query: 839  -RYRQELKDLQEQQ--REEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQERE 895
             +  + LK L EQ+  R+ +++    KD L +  +   + L    + E+    +  + +E
Sbjct: 903  IKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKE 962

Query: 896  MLEK---------TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKR 946
              EK           K+ L+S   E Q + ++LE LR+  +   + + D +++   S+K 
Sbjct: 963  KEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRD-LIQGAESYKN 1021

Query: 947  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1006
             L E E+       SEQL  ++      EH   R E +++ L    +    CET + +  
Sbjct: 1022 LLLEYEK------QSEQLDVEKERANNFEH---RIEDLTRQLRNSTLQ---CETINSDNE 1069

Query: 1007 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1066
            ++   I  LQS  K ++     L + ++   V  E E E         Q EQ ++E+   
Sbjct: 1070 DLLARIETLQSNAKLLE--VQILEVQRAKAMVDKELEAE-------KLQKEQKIKEHATT 1120

Query: 1067 LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPF 1126
            +  L+    Q  KE      ++ +  Q L+ ++     ++ ++    ++     E  +  
Sbjct: 1121 VNELEELQVQLQKEK----KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKL 1176

Query: 1127 LQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK-IEESEASVEGFSELEN 1185
               N+  ++E + +   +   + + +++  ++  SSVQ+ E K  +  +  V+   EL +
Sbjct: 1177 --TNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD 1234

Query: 1186 SEETRTE----SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERI 1241
            S++  T+       LK ++   Q+Q+ +                    +  +K K+ E +
Sbjct: 1235 SKQAETDHLILQASLKGELEASQQQVEVYKIQL-------------AEITSEKHKIHEHL 1281

Query: 1242 PEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT 1301
              ++ +++       +    LQEE R  +    E      E  +   R+ + LK+ +  +
Sbjct: 1282 KTSAEQHQRTLSAYQQRVTALQEECRAAKA---EQATVTSEFESYKVRVHNVLKQQKNKS 1338

Query: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1361
             +    +   +  K E E L +L+ +L+ K++  Q ++       +  + L+ L+ E D 
Sbjct: 1339 MS----QAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ------INVSELQTLQSEHDT 1388

Query: 1362 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTIQTHQ 1420
             + + N+ L+E V +   +   +   + EN  ++  +TQ + ++          T Q   
Sbjct: 1389 LLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQL----------TSQNEV 1438

Query: 1421 ERPRVQNQVILEENTTLLGFQDKHFQ--HQATIAELELEKTKLQELTRKLKERVTIL--V 1476
             R   ++QV             +H Q  H+ T+  L+ + +K++    +LK   T    V
Sbjct: 1439 LRNSFRDQV-------------RHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485

Query: 1477 KQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE 1536
              +  L +  +       + D+     E  + +E    ++E +   ++  ++    LN  
Sbjct: 1486 SSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETT--DTESVSSASTYTQSLEQLLNSP 1543

Query: 1537 DSISNLKLGTLNGSQEEMWQK----TETVKQENAAVQKMVENLKKQISELK-IKNQQLDL 1591
            ++     L     ++EE+ QK    T++    N  +++        + ++K +K++   L
Sbjct: 1544 ETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRL 1603

Query: 1592 ENTELSQKNSQNQEKLQEL 1610
            E  +  +K++ N E L+ +
Sbjct: 1604 ERNQEREKSAANLEYLKNV 1622



 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 167/758 (22%), Positives = 328/758 (43%), Gaps = 137/758 (18%)

Query: 341  ELTLALENEL-LVTKNSIHQ-----AALASFKAEIRHLLERVDQVVREKEKLRSDLDKAE 394
            E  L LE E+  + + S+ Q     + L  ++ E   L + ++++  EKE L+SDL    
Sbjct: 806  EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDL---- 861

Query: 395  KLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 454
             L+   A+E         R    NL    EE  +  +  K+E+  E+E+   +       
Sbjct: 862  -LEMKNANEK-------TRLENQNLLIQVEEVSQTCS--KSEIHNEKEKCFIK------- 904

Query: 455  LEQEIEKAKTEENYIRDRLA-LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLA 513
             E E  K   E+  +RDR A L L ++S  ++  ++N + L+  + L  K++ NLE    
Sbjct: 905  -EHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN-DPLSSVKELEEKIE-NLEKECK 961

Query: 514  EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLK 573
            EK   ++         ++ L   R E     + ++++++ L+SE ++  A  R L   ++
Sbjct: 962  EKEEKINKIKLVAVKAKKELDSSRKE----TQTVKEELESLRSEKDQLSASMRDL---IQ 1014

Query: 574  NSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKV 633
             + S +                      N+ +E E   EQ+  +  R         E ++
Sbjct: 1015 GAESYK----------------------NLLLEYEKQSEQLDVEKER-----ANNFEHRI 1047

Query: 634  RHYEKQLDETVVSCK---KAQENMKQRHENETHTLEKQISDLKNEIAELQ-GQAAVLKEA 689
                +QL  + + C+      E++  R E    TL+     L+ +I E+Q  +A V KE 
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIE----TLQSNAKLLEVQILEVQRAKAMVDKEL 1103

Query: 690  HHEATCRHEE---------EKKQLQVKLEEEKTHLQEKLR----LQHEMELKARLTQAQA 736
              E   + ++         E ++LQV+L++EK  LQ+ ++    ++ + +    +    A
Sbjct: 1104 EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIA 1163

Query: 737  SFEREREGL-QSSAWTEEKVRGLTQEL------EQFHQEQLTSL---VEKHTLEKEELRK 786
             +ER  + L Q       K+  L QE+      ++  QE++TSL   V+++  EK    K
Sbjct: 1164 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYE-EKNTKIK 1222

Query: 787  ELLEKHQRELQEGRE----------KMETECNRRTSQIE------AQFQSDCQKVTERCE 830
            +LL K ++EL + ++           ++ E      Q+E      A+  S+  K+ E  +
Sbjct: 1223 QLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK 1282

Query: 831  SALQSLE---GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTS 887
            ++ +  +     Y+Q +  LQE+ R  K+    E+  +T E    +  +   LK++K  S
Sbjct: 1283 TSAEQHQRTLSAYQQRVTALQEECRAAKA----EQATVTSEFESYKVRVHNVLKQQKNKS 1338

Query: 888  LVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE 947
              ++Q      K  +EHL  ++ + +  LQD ++   ++ ++   L  +   L   H + 
Sbjct: 1339 --MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKM 1396

Query: 948  LRER-------EEVLCQAGASEQLA----SQRLERLEMEHDQERQEMMSKLLAMENIHKA 996
            L+E         E LC   +   +     +Q + +L  +++  R     ++  ++  H+ 
Sbjct: 1397 LQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK 1456

Query: 997  TCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1034
            T ET  ++ ++M  ++ +L    K      SP+S  QS
Sbjct: 1457 TVETLQQQLSKMEAQLFQL----KNEPTTRSPVSSQQS 1490



 Score = 89.4 bits (220), Expect = 4e-17
 Identities = 152/719 (21%), Positives = 308/719 (42%), Gaps = 102/719 (14%)

Query: 1455 ELEKTKLQELTRKLKERVTILVKQKDVLSHGEKE-EEL--KAMMHDLQITCSEMQQKVEL 1511
            +LE    ++L +  K+++ ++ K K   +  EKE EEL  K +          + ++++ 
Sbjct: 21   KLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDA 80

Query: 1512 LRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMW----QKTETVKQENAA 1567
            L  E  + +Q+   L+ E   + +E   S  K+G  +   E+      ++ E +K E  A
Sbjct: 81   LLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMA 140

Query: 1568 VQKMVE----NLKKQISELKIKNQQLDLENTELSQKNSQN-----QEKLQELNQRLTEML 1618
            V+        NL+KQ+ E    N QL+L      Q NS++     QE+++++     E +
Sbjct: 141  VRSKYSEDKANLQKQLEEAM--NTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQI 198

Query: 1619 CQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHL 1678
               +K+  ++  +E+++    L+  +E         ++SL+ EL ++K    I Q+E   
Sbjct: 199  LYLQKQL-DATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKA---IHQEEVKE 254

Query: 1679 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEH 1738
            L  ++E   + H        + +I+ +    E L+K+ EA  +     + K  +  L   
Sbjct: 255  LMCQIEASAKEH--------EAEINKLNELKENLVKQCEASEKN----IQKKYECELENL 302

Query: 1739 RIATMKQEQKSWEHQSASLKSQLVASQ---EKVQNLEDTVQNVNLQMSRMKSDLRVTQQE 1795
            R AT    Q + +  S  L+      Q   EKV++LEDT++ +  Q S +K +  VT   
Sbjct: 303  RKATSNANQDN-QICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDE--VTYMN 359

Query: 1796 KEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE 1855
               LK E+ + H + +                   ++++ L +   + L+ +E+Q     
Sbjct: 360  NLKLKLEMDAQHIKDE-----------------FFHEREDLEFKINELLLAKEEQGC--V 400

Query: 1856 NERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT--MNPTEQEKLSL----- 1908
             E+L++ +     +  ++ E+  +   +L  +HQK ++      ++ +E+EKL+L     
Sbjct: 401  IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 460

Query: 1909 --KRECDQFQKEQSPANRKVSQMNSLEQELET--------IHLENEGLKKKQVKLDEQLM 1958
              K +C+  Q+E+  A      +  + + L+T        I  E E +K++Q     +L 
Sbjct: 461  GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520

Query: 1959 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE----- 2013
              Q LR+  T   +       LL+         E+ L  Q  + + E   ++LQE     
Sbjct: 521  --QKLRTAFTEKDA-------LLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVY 571

Query: 2014 ------------ELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQL 2061
                        ELE + +     + +    +    E M    +K +  +RL+ E   ++
Sbjct: 572  LLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKV 631

Query: 2062 KEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVRNL 2120
            ++ +  N++ +  V +L     + LK  +  +Q+ +    +  +L E    LS  V++L
Sbjct: 632  EQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSL 690


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  201 bits (511), Expect = 6e-51
 Identities = 417/1964 (21%), Positives = 818/1964 (41%), Gaps = 280/1964 (14%)

Query: 304  HASVERILDTWQEEGIENSQEILKALDFSLDGNIN-LTELTLALENELLVTKNSIHQAAL 362
            +  +E  +  +Q + +E  +++   L+  L    N +T+LT  ++ +  V K+ +    L
Sbjct: 662  YKQMENDIQLYQSQ-LEAKKKMQVDLEKELQSAFNEITKLTSLIDGK--VPKDLLCNLEL 718

Query: 363  ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEY----- 417
               + +I  L + +++ V E E LR ++    +LKSL  SEV+     I+ ++E      
Sbjct: 719  ---EGKITDLQKELNKEVEENEALREEVILLSELKSL-PSEVERLRKEIQDKSEELHIIT 774

Query: 418  -NLRKLDEE--YKE-RIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRL 473
                KL  E  +KE R+  L  E+ K ++ +       +   +QE +  KT       + 
Sbjct: 775  SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYK-STDQEFQNFKTLHMDFEQKY 833

Query: 474  ALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL 533
             + L+EN R+  E++  +++  ++++    L+  L    + K  +L   + E   +   +
Sbjct: 834  KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL----SYKTQELQEKTREVQERLNEM 889

Query: 534  TQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHG- 592
             Q++ + E +   LQ    E +  L   + Q  +  +       ++++     ++ E   
Sbjct: 890  EQLKEQLENRDSTLQTV--EREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947

Query: 593  LGSEECNPLNMSIEAELVIEQMKE---QHHRDICCLRLELEDKVR---HYEKQLDETVVS 646
            L S+  + +NM+I+ +  +    E   QH   I  L+ ++ ++V    H E+   ET   
Sbjct: 948  LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007

Query: 647  CKKAQENMKQRHENETHTLEKQISDLK-NEIAELQGQAAVLKEAHHEATCRHEE---EKK 702
             ++    + ++ + E    +   +D+K NEI E Q +   L +  +E     E    EK+
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067

Query: 703  QLQVKLEEE---KTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSS-----AWTEE 753
            QL+  L+E        QE+LRL   E++ +  +   + +   ++EG  S      A  EE
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127

Query: 754  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
            K++  +Q+L++  Q+ L    E   ++K+    E L+   +  +   E METE      +
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187

Query: 814  IEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ---ECA 870
            +   ++       ER    L+ L+  +  E   L+   RE ++     K+EL        
Sbjct: 1188 LNENYEEVKSITKER--KVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLK 1245

Query: 871  EAQELLKETLKR--EKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 928
            E QE + E  +   EKT  ++ TQ+ E      +E +  ++ E Q+LL ++++   VSET
Sbjct: 1246 EHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI-PVLHEEQELLPNVKE---VSET 1301

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM-EHDQERQEMMSKL 987
            Q+++   ++L  +S+ K               S  LA   +ERL + E  QE QE +  L
Sbjct: 1302 QETMNELELLTEQSTTKD--------------STTLARIEMERLRLNEKFQESQEEIKSL 1347

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ-QATSPLSMLQSG---CQVIGEEE 1043
                +  K   E  + +  ++   I    +KI+E Q +    L+M +      +++ E E
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEME 1407

Query: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
                   +LL+   ++L     +   LQ +H++ +K   K   ++ RLQ+ LQ       
Sbjct: 1408 QFKPKDSALLRIEIEML----GLSKRLQESHDE-MKSVAKEKDDLQRLQEVLQS------ 1456

Query: 1104 MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1163
             S  L E   E      E  E     +   + +  T   +  +L + E      T  S++
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE------TEISTI 1510

Query: 1164 QRQEVKIEESEASVEGFSELENSEETRTESWELKN--QISQLQEQLMMLCADCDRASEKK 1221
            Q+Q   I +         +L+N  +   E  E  N  QIS++QE++  L    +    K 
Sbjct: 1511 QKQLEAIND---------KLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD 1561

Query: 1222 QDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNK 1281
              L    S+  K L++  R+ E+  + +++ ++   E   +QE L++     D+  EN K
Sbjct: 1562 SALQ---SIESKMLELTNRLQESQEEIQIMIKE-KEEMKRVQEALQIER---DQLKENTK 1614

Query: 1282 ELTAEVFRLQD---ELKKMEEVTET------FLSLEKSYDEVKIENEELNVLVLRL---- 1328
            E+ A++   Q+   +  KM  V ET         L++ ++  K+  E +    +RL    
Sbjct: 1615 EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQIL 1674

Query: 1329 QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECK 1388
               +E+++    +R D    E   E L++E D    QL + L E + R        EE K
Sbjct: 1675 HENLEEMRSVTKERDDLRSVE---ETLKVERD----QLKENLRETITRDLEKQ---EELK 1724

Query: 1389 QENQYLEGNTQLLEKV------KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQD 1442
              + +L+ + + ++K+      K +EI+ +   ++   +  + Q+  I EE    L    
Sbjct: 1725 IVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE----LRIAH 1780

Query: 1443 KHF-QHQATI------------------AELELEKTKLQELTRKLKERVTILVKQKDVLS 1483
             H  + Q TI                   +LE    KLQE  ++LK     L+  K  ++
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVN 1840

Query: 1484 HGEKE----EELKAMMHDLQITCSEMQ-------QKVELLRYESEKLQQENSILRNEITT 1532
              +K+    E+LK  + D  +T S+++       QK+     E + + +E   LR    T
Sbjct: 1841 ETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEET 1900

Query: 1533 LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1592
            L  E       L        E+ Q+ +T +  +   ++ V+ L+++ISE   K  Q+   
Sbjct: 1901 LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISE---KTIQISDI 1957

Query: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEK-EPGNSALEEREQEKFNLKEE---LERCK 1648
              +L +   + Q+K+QEL ++  ++L  KE     +  + E EQ K   + +   ++  +
Sbjct: 1958 QKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVR 2017

Query: 1649 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ---LHRCPDLSDFQQKISSV 1705
            + +  L   L   L E++    IV +E    +DEL ++K+   + R   ++  ++ I+  
Sbjct: 2018 MDNFQLTKKLHESLEEIR----IVAKE----RDELRRIKESLKMERDQFIATLREMIARD 2069

Query: 1706 LSYNEKLLKEKEALSEE----LNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1761
               N ++  EK  LS+       S  +K ++   L  R + M    +     S  L+ ++
Sbjct: 2070 -RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128

Query: 1762 VASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPE 1821
               +E    ++  +    LQ   ++      Q+       E   + K+L+     S+  +
Sbjct: 2129 EFQKELSMRVKANLSLPYLQTKHIEKLFTANQR----CSMEFHRIMKKLKYV--LSYVTK 2182

Query: 1822 IATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE---------NERLQTMVQNTKAELTH 1872
            I       H    +   D +D +  +++ L+  +         +  L+ +  N   +L H
Sbjct: 2183 IKEEQ---HESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL-H 2238

Query: 1873 SREKVRQLESNLLP----KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQ 1928
              E ++    +  P    + Q+ L+    M    +E L+ + + ++ +      N ++ Q
Sbjct: 2239 IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ 2298

Query: 1929 MNSL--------------------------EQELETIHLENEGLKKKQVKLDEQLMEMQH 1962
            +N+                           EQ+L+++  +NE L K    L   L     
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ 2358

Query: 1963 LRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQH-------LQEEL 2015
            +  T   + +PH              +  E+  +L+  L +A+    H       +Q+EL
Sbjct: 2359 VNPTTQDNKNPHV-------TSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKEL 2411

Query: 2016 E----------NRTSETNTPQGNQEQLVTVMEERMI--------EVEQ-KLKLVKRLLQE 2056
            E           +  E+N      ++ + V+++++         E+E  K+KLVK  L E
Sbjct: 2412 EVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDL-E 2470

Query: 2057 KVNQLKEQLCKNTKADAMVKDLYVENAQLLKA-LEVTEQRQKTA 2099
            K+   KE   K   A     +   E  +LL+  L  ++Q Q T+
Sbjct: 2471 KMKNAKE-FEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTS 2513



 Score =  199 bits (505), Expect = 3e-50
 Identities = 411/2021 (20%), Positives = 830/2021 (41%), Gaps = 408/2021 (20%)

Query: 377  DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 436
            + +  E   LR+D D        + +E ++    ++ +N+     LDE       AL+ +
Sbjct: 494  ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKND-----LDE-----FEALERK 543

Query: 437  LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAE 496
             +K++E          ++L  EI   K   N ++         N  LENEL    E L E
Sbjct: 544  TKKDQE----------MQLIHEISNLK---NLVKHAEVY----NQDLENELSSKVELLRE 586

Query: 497  YENLTNKLQ-----RNLENVLAEKFGDL----DPSSAEFFLQEERLTQMRNEYERQCRVL 547
             E+   KLQ     + LEN+  +    L    DP   +  L +     +  + +R+   L
Sbjct: 587  KEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL--DAKRESAFL 644

Query: 548  QDQVDELQSELEEYRAQGRVLR--LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSI 605
            + +  EL+ +++E     + +   + L  S  E  +     +E E      E   L   I
Sbjct: 645  RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLI 704

Query: 606  EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE----NE 661
            + ++          +D+ C  LELE K+   +K+L+      K+ +EN   R E    +E
Sbjct: 705  DGKV---------PKDLLC-NLELEGKITDLQKELN------KEVEENEALREEVILLSE 748

Query: 662  THTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE----------- 710
              +L  ++  L+ EI +   +  ++     +       ++ ++Q  LEE           
Sbjct: 749  LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATT 808

Query: 711  --------------EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT----- 751
                          +  H+  + + +  +E   R+ Q   +  +E +   SS        
Sbjct: 809  QSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL 868

Query: 752  -------EEKVRGLTQELEQFHQ--EQLTSLVEKHTLEKEELRKELL-EKHQRELQE--- 798
                   +EK R + + L +  Q  EQL +     TL+  E  K L+ EK Q+ L+E   
Sbjct: 869  SYKTQELQEKTREVQERLNEMEQLKEQLEN--RDSTLQTVEREKTLITEKLQQTLEEVKT 926

Query: 799  -GREKMETECNRRTSQIEA-QFQSDCQKVT-------ERCESALQSLEGRYRQELKDLQE 849
              +EK + +  + + QIE  Q +SD            E+  +AL+SL+ ++++ +  L+ 
Sbjct: 927  LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK-QHQETINTLKS 985

Query: 850  QQREEKSQWEFEKDELTQECAEAQELL-----KETLKREKTTSL--------VLTQEREM 896
            +  EE S+    ++   +   E Q+ +     K+ L+ + T +L        ++ Q+R++
Sbjct: 986  KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045

Query: 897  L-----EKTYKEHLNSMVVERQQLLQDL-EDLRNVSETQQS--LLSDQI---LELKSSHK 945
                  +   ++ L S++ E++QL  DL E++    E Q+   LL D++    E+ +  K
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105

Query: 946  RELREREEVLCQ-----AGASEQL--ASQRLERLE---MEHDQERQEMMSKLLAMENI-- 993
                ++E  L +     A   E+L   SQ+L+  +   +   +E  EM  K+  +EN+  
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165

Query: 994  ----HKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE------EE 1043
                 + T E  + ER E++ +++    ++K + +    L  LQ   +   +       E
Sbjct: 1166 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE 1225

Query: 1044 VEGDGALSLLQQGEQL------LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK 1097
            +E  G    LQ  E+L      L+E+ + +  L+R+  +   + +    ++ +   +LQ+
Sbjct: 1226 IEATG----LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN-TQDLEKSHTKLQE 1280

Query: 1098 LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGS 1157
              P L           E   N  E +E    Q    ++E +T +    D          S
Sbjct: 1281 EIPVL-------HEEQELLPNVKEVSE---TQETMNELELLTEQSTTKD----------S 1320

Query: 1158 TGTSSVQRQEV----KIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCAD 1213
            T  + ++ + +    K +ES+  ++  ++  ++ +T  E+ E+K+   QL+E +    A 
Sbjct: 1321 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH--DQLKEHIRETLAK 1378

Query: 1214 CDRASEKKQDLL---------------------FDVSVLKKKLKML---ERIPEASPKYK 1249
               +  K++  L                      D ++L+ +++ML   +R+ E+  + K
Sbjct: 1379 IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMK 1438

Query: 1250 LLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELK--------KMEEVT 1301
                 V++E D LQ    ++++  D+  EN KE+ A+    ++ELK        + E + 
Sbjct: 1439 ----SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETIN 1494

Query: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP-- 1359
            E  ++L +   E+    ++L  +  +LQ KI+++ E   Q     + E   +  E++   
Sbjct: 1495 ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK 1554

Query: 1360 -------------DGNILQLNQTLEECVPRVRSVHHVIEECK--------QENQYLEGNT 1398
                         +  +L+L   L+E    ++ +    EE K        + +Q  E   
Sbjct: 1555 EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK 1614

Query: 1399 QLLEKVKAH---------------------EIAWLHGTIQTHQ------ERPRVQNQVIL 1431
            +++ K+K                       EI  L    +T +      E   ++   IL
Sbjct: 1615 EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQIL 1674

Query: 1432 EENTTLLGFQDKHFQHQATIAE-LELEKTKLQE-----LTRKLKERVTILVKQKDVLSHG 1485
             EN   +    K      ++ E L++E+ +L+E     +TR L+++  + +    +  H 
Sbjct: 1675 HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQ 1734

Query: 1486 EKEEELKAMMHDLQITCSEMQQKVE----LLRYESEKLQQENSI----LRNEITTLN--- 1534
            E  ++L+ ++ +     S MQ+ +E     L+ +  K+Q+E  I    L+ +  T++   
Sbjct: 1735 ETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR 1794

Query: 1535 -----EEDSISNLK--LGTLNGSQEEMWQKTE-------TVKQENAAVQKMV---ENLKK 1577
                 + D +SN++  L   N   +E  Q+ +       T+K++    QK V   E LKK
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQEL-----NQRLTEMLCQKEKEPGNSALEE 1632
            QI +  +   +L++EN  L+QK  +N E+++ +     N R  E   + E++    +L+E
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQE 1914

Query: 1633 REQEKFNLKEELERCKVQS---STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL 1689
             +     +++EL+  ++ S      V  L  ++SE  IQ   +Q++    KDEL+K    
Sbjct: 1915 TKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK---- 1970

Query: 1690 HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKS 1749
                       KI  +     +LL+ KE +              ++   +I  M+Q +K 
Sbjct: 1971 -----------KIQELQKKELQLLRVKEDV--------------NMSHKKINEMEQLKKQ 2005

Query: 1750 WEHQSASLKSQLVASQEKVQNLEDTVQNVNL------QMSRMKSDLRVTQQEKEALKQEV 1803
            +E Q+ S++S  + + +  + L ++++ + +      ++ R+K  L++ + +  A  +E+
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065

Query: 1804 MSLHKQLQNAGGKSWAPEIATHPSGLHN--QQKRLSWDKLDHLMNEEQQLLWQENERLQT 1861
            ++  +Q          PE      G  +  +  R    ++  L+    + +    E L  
Sbjct: 2066 IARDRQNHQV-----KPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE-MDDHYECLNR 2119

Query: 1862 MVQNTKAELTHSREKVRQLESNL-LPKHQ-KHLNPSGTMNPTEQEKLSLKRECDQFQKEQ 1919
            +  + + E+   +E   ++++NL LP  Q KH+    T N         +R   +F +  
Sbjct: 2120 LSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTAN---------QRCSMEFHRIM 2170

Query: 1920 SPANRKVSQMNSL-EQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDL 1978
                  +S +  + E++ E+I+        +  K  E L+++QHL+      PS    DL
Sbjct: 2171 KKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDC-DVPSRELRDL 2229

Query: 1979 QLLQ------QQACPMVPREQF----LQLQRQLLQAERINQHLQEELENRTSETNTPQGN 2028
            +L Q      ++        +F     + Q+ L   + + Q L+E L  R        G 
Sbjct: 2230 KLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGI 2289

Query: 2029 QEQ--------------LVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAM 2074
            Q++              ++ +M E   E E++   + +  ++ +  LKE+  K  K    
Sbjct: 2290 QKENDRICQVNNFFNNRIIAIMNE-STEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2348

Query: 2075 VKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSN 2115
            +K      AQ+    +  +    T+ +   L  EKI  L N
Sbjct: 2349 LKTSLASGAQVNPTTQDNKNPHVTS-RATQLTTEKIRELEN 2388



 Score =  164 bits (414), Expect = 1e-39
 Identities = 356/1708 (20%), Positives = 715/1708 (41%), Gaps = 300/1708 (17%)

Query: 347  ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDL--------DKAEKLKS 398
            +NE++  +  I   +L   K E++ +LE    V+ EKE+L++DL        +  E+L+ 
Sbjct: 1035 DNEIIEQQRKIF--SLIQEKNELQQMLE---SVIAEKEQLKTDLKENIEMTIENQEELR- 1088

Query: 399  LMASEVDDHHAAIERRNEYNLRKLDEEYK--ERIAALKNELRKEREQILQQAGKQRLELE 456
            L+  E+      + +   + ++K  E  +  +R+A ++ +L KE+ Q LQ+  +Q L ++
Sbjct: 1089 LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL-KEKSQQLQEKQQQLLNVQ 1147

Query: 457  QEIEKAKTEENYIRDRLALSLKENS----RLENELLENAEKLAE-YENLTNKLQRNLENV 511
            +E+ + + + N I + L   LK        +E E LE A+KL E YE + +  +      
Sbjct: 1148 EEMSEMQKKINEI-ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK 1206

Query: 512  LAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL-----QDQVDELQSELEEYRAQGR 566
              +K  + +      +++E   T ++ + E +   +     Q+ +DEL+  + E  AQ  
Sbjct: 1207 ELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ-- 1264

Query: 567  VLRLPLKNSPSEEVEANSGGIEPEHGL------GSEECNPLNMSIEAELVIEQMKEQHHR 620
            ++          +++     +  E  L       SE    +N   E EL+ EQ   +   
Sbjct: 1265 IINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMN---ELELLTEQSTTKDST 1321

Query: 621  DICCLRLELEDKVRHYEK--QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE 678
             +   R+E+E ++R  EK  +  E + S  K ++N+K   E     LE +   LK  I E
Sbjct: 1322 TLA--RIEME-RLRLNEKFQESQEEIKSLTKERDNLKTIKE----ALEVKHDQLKEHIRE 1374

Query: 679  LQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASF 738
               +    +    ++    E++ +  ++  E E+   ++   L+ E+E+     + Q S 
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434

Query: 739  EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKE---LLEKHQ-- 793
            +  +   +     +     L  E +Q  +E +  +V KH   +EEL+     L E+ +  
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQL-KENIKEIVAKHLETEEELKVAHCCLKEQEETI 1493

Query: 794  RELQEGREKMETECNRRTSQIEA---QFQSDCQKVTERCE-------------------- 830
             EL+    + ETE +    Q+EA   + Q+  Q++ E+ E                    
Sbjct: 1494 NELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQF 1553

Query: 831  --------SALQSLEGRYRQELKDLQEQQRE------EKSQW-------EFEKDELTQEC 869
                    SALQS+E +  +    LQE Q E      EK +        + E+D+L +  
Sbjct: 1554 KEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT 1613

Query: 870  AEAQELLKETLKRE----KTTSLVLTQER----EMLEK---TYKEHLNSMVVERQQLLQ- 917
             E    +KE+ ++E    K T++  TQE+    E L++   T K +L ++  E  +L Q 
Sbjct: 1614 KEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQI 1673

Query: 918  ---DLEDLRNVSETQQSLLS---------DQILE-LKSSHKRELREREEVLCQAGASEQL 964
               +LE++R+V++ +  L S         DQ+ E L+ +  R+L ++EE+        ++
Sbjct: 1674 LHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEEL--------KI 1725

Query: 965  ASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAE---MSTEISRLQSKIKE 1021
                L+  +   D+ R  +  K   + N+ K    + D  +A+   +  E+      +KE
Sbjct: 1726 VHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE 1785

Query: 1022 MQQATSPL-SMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1080
             Q+    L  ++      +   + + + + + LQ+  Q L+ N   L++L++     V E
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKD----VNE 1841

Query: 1081 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGV 1138
              K  +E+ +L+++++  +  L +S    E       N A++    L++ ++  K+ + +
Sbjct: 1842 TQKKVSEMEQLKKQIK--DQSLTLSKLEIENL-----NLAQKLHENLEEMKSVMKERDNL 1894

Query: 1139 TRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKN 1198
             R      LE D++++           QE K  + E   E  +    S+E +    +L+ 
Sbjct: 1895 RRVEETLKLERDQLKE---------SLQETKARDLEIQQELKTARMLSKEHKETVDKLRE 1945

Query: 1199 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE 1258
            +IS+   Q+  +  D D++ ++ Q  + ++   KK+L++L    + +  +K + E    +
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQ--KKELQLLRVKEDVNMSHKKINEMEQLK 2003

Query: 1259 NDCLQEELRMMETRYD-----EALENNKELTAEVFRLQDELKKMEE-----------VTE 1302
                 + L M   R D     + L  + E    V + +DEL++++E              
Sbjct: 2004 KQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLR 2063

Query: 1303 TFLSLEKSYDEVKIENEELNV----LVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIE 1358
              ++ ++   +VK E   L+     L   L+ K  +++E + +  +       L  L ++
Sbjct: 2064 EMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLD 2123

Query: 1359 PDGNI-----LQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLH 1413
             +  I     L +       +P +++ H  IE+    NQ        + K   + ++++ 
Sbjct: 2124 LEKEIEFQKELSMRVKANLSLPYLQTKH--IEKLFTANQRCSMEFHRIMKKLKYVLSYVT 2181

Query: 1414 GTIQT-HQERPRVQNQVILE-ENTTLLGFQDKHFQHQATIAELELEKTKL--------QE 1463
               +  H+   + +   I E E    L  + +H Q    +   EL   KL        +E
Sbjct: 2182 KIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEE 2241

Query: 1464 LTRKLKERV--TILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1521
            + +   E    +I  + + VLS+    +E+   + +   T  ++++    ++ E++++ Q
Sbjct: 2242 ILKDFSESEFPSIKTEFQQVLSN---RKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ 2298

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI-S 1580
             N+   N I  +  E +    +  T++   +E  Q  +++K++N  + K  + LK  + S
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATIS---KEWEQDLKSLKEKNEKLFKNYQTLKTSLAS 2355

Query: 1581 ELKIKNQQLDLENTELSQKNSQ-NQEKLQELNQRLTE------------MLCQKEKE--- 1624
              ++     D +N  ++ + +Q   EK++EL   L E            +  QKE E   
Sbjct: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTN 2415

Query: 1625 -----------PGNSALEERE------QEKFNL-----KEELERCKVQSSTL-------V 1655
                         N  LE+ +      Q+K  L     KEE+E  K++   +        
Sbjct: 2416 DIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNA 2475

Query: 1656 SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL--------HRCPDLSD---------- 1697
               E E+S  K      ++   LL++ L + +Q         H  P  S+          
Sbjct: 2476 KEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSG 2535

Query: 1698 ----------------FQQKISSVLSYNEKLLKEK-------EALSEELNSCVDKLAKSS 1734
                             +++IS +   NE+L+K+K       + LS E+ +  ++  K  
Sbjct: 2536 IVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKRE 2595

Query: 1735 LLEHRIATMKQEQKSWE-HQSASLKSQLVASQEKVQNLEDTVQNVNLQM----SRMKSDL 1789
               H+  T +   KS +   +AS K Q+  SQ K +NL+D V   + +     SR KS  
Sbjct: 2596 --AHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKS-- 2651

Query: 1790 RVTQQEKEALKQEVMSLHKQLQNAGGKS 1817
              +           + L  ++QNAG +S
Sbjct: 2652 LPSPHPVRYFDNSSLGLCPEVQNAGAES 2679



 Score =  148 bits (373), Expect = 6e-35
 Identities = 327/1535 (21%), Positives = 630/1535 (41%), Gaps = 313/1535 (20%)

Query: 834  QSLEGRYRQELKDLQEQQRE---EKSQWEFEKDELTQECAEAQELLK-ETLKREKTTSLV 889
            ++L  RYR+E+ DL++Q  E   E      EKD+L Q   E   L K +  K E  T ++
Sbjct: 342  EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401

Query: 890  LTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE-- 947
            +T     L++  K      V      L  +  ++N +   Q  +   I     +HK    
Sbjct: 402  VTSSSLTLQQELKAKRKRRVT---WCLGKINKMKNSNYADQFNIPTNI--TTKTHKLSIN 456

Query: 948  -LREREEVLCQAGASEQLASQRLERL-EMEHDQERQEMMSKLLAMENIH------KATCE 999
             LRE +E +C   +   + S  L+ L E+E +       +KLL  ENI       +A  +
Sbjct: 457  LLREIDESVC---SESDVFSNTLDTLSEIEWNP-----ATKLLNQENIESELNSLRADYD 508

Query: 1000 TADRERAEMSTEISRLQSKIKEMQ-----QATSPLSMLQSGCQVIGE----------EEV 1044
                +  ++ TE   ++ K+KE       +A    +      Q+I E           EV
Sbjct: 509  NLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEV 568

Query: 1045 EGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEIS--------RLQQRL- 1095
                  + L    +LL E  D +  LQ   +    EN+KM    S        +++Q L 
Sbjct: 569  YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLF 628

Query: 1096 --------QKLEPGLVMSSCLD-EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSD 1146
                     K E   + S  L+ +   +    T +Q E  +Q  ++ Q+E   +  V  D
Sbjct: 629  DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS-QLEAKKKMQV--D 685

Query: 1147 LEDD------EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1200
            LE +      E+  L S     V +  +   E E  +    +  N E    E+  L+ ++
Sbjct: 686  LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA--LREEV 743

Query: 1201 SQLQEQLMMLCADCDRASEKKQDLLFDVSVL-KKKLKMLERIPEASPKYKLLYEDVSREN 1259
              L E L  L ++ +R  ++ QD   ++ ++  +K K+   +     + + L E++ +  
Sbjct: 744  ILLSE-LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK 802

Query: 1260 DCLQ----------------EELRM-METRYDEALENNKELTAEVFRLQDELKKMEEVTE 1302
            D L                 + L M  E +Y   LE N+ +  E+  L  E +K +    
Sbjct: 803  DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS--- 859

Query: 1303 TFLSLEKSYDEVKIENEELNVLVLRLQ---GKIEKLQESVVQRCDCCLWEASLENLEIEP 1359
               SL     E+  + +EL      +Q    ++E+L+E +  R      +++L+ +E E 
Sbjct: 860  ---SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR------DSTLQTVEREK 910

Query: 1360 DGNILQLNQTLEECVPRVRSVHHVIEECKQ-------------------ENQYLEGNTQL 1400
                 +L QTLEE    V+++    ++ KQ                    N  ++   QL
Sbjct: 911  TLITEKLQQTLEE----VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQL 966

Query: 1401 ---LEKVKAHEIAWLHGTIQTHQER--PRVQNQVILEENTTLLGFQDKHFQHQ--ATIAE 1453
               LE +K H+      TI T + +    V   + +EENT   G     FQ +      +
Sbjct: 967  RNALESLKQHQ-----ETINTLKSKISEEVSRNLHMEENT---GETKDEFQQKMVGIDKK 1018

Query: 1454 LELEKTKLQELTRKLKE--------RVTILVKQKDVLSH------GEKEEELKAMMHDLQ 1499
             +LE    Q LT  +K+        ++  L+++K+ L         EKE+    +  +++
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078

Query: 1500 ITCSEMQQKVELLRYESEK-----LQQENSILRNEITTLNEEDSISNL--KLGTLNGSQE 1552
            +T  E Q+++ LL  E +K      Q++N  ++ E       D ++ +  KL   +   +
Sbjct: 1079 MTI-ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137

Query: 1553 EMWQKTETVKQENAAVQKM---VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQE 1609
            E  Q+   V++E + +QK    +ENLK ++   ++  + ++ E  EL+QK ++N E+++ 
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKS 1197

Query: 1610 LNQ-----RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV--------------- 1649
            + +     +  +   + E++     + E E      KEEL+   +               
Sbjct: 1198 ITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS 1257

Query: 1650 ---QSSTLVSSLEAELSEVKIQTHI--VQQENHLL------------KDELE-------- 1684
               +++ ++++ + E S  K+Q  I  + +E  LL             +ELE        
Sbjct: 1258 VSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTT 1317

Query: 1685 ---------KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA-------LSEELNSCVD 1728
                     +M++L       + Q++I S+    + L   KEA       L E +   + 
Sbjct: 1318 KDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA 1377

Query: 1729 KLAKSSLLEHRIATMKQ----------EQKSWEHQSASL---KSQLVASQEKVQNLEDTV 1775
            K+ +S   + +   MK+          E + ++ + ++L   + +++   +++Q   D +
Sbjct: 1378 KIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEM 1437

Query: 1776 QNVNLQMSRMKSDLRVTQQEKEALKQ---EVMSLHKQLQNAGGKSWAPEIATHPSGLHNQ 1832
            ++V  +   ++    V Q E + LK+   E+++ H + +         E+      L  Q
Sbjct: 1438 KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEE--------ELKVAHCCLKEQ 1489

Query: 1833 QK-----RLSWDKLDHLMNEEQQLLWQENERLQTMVQ---------NTKAELTHSREKVR 1878
            ++     R++  + +  ++  Q+ L   N++LQ  +Q         N K +++  +EKV 
Sbjct: 1490 EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIK-QISEVQEKVN 1548

Query: 1879 QLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELET 1938
            +L+     +H+K       +   E + L L    ++ Q+ Q      + +   +++  E 
Sbjct: 1549 ELKQ--FKEHRK--AKDSALQSIESKMLEL---TNRLQESQEEIQIMIKEKEEMKRVQEA 1601

Query: 1939 IHLENEGLKKKQVKL-----DEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQ 1993
            + +E + LK+   ++     + Q  E Q L+ TA         +++ L++Q        Q
Sbjct: 1602 LQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQF-----ETQ 1656

Query: 1994 FLQLQRQLLQAERINQHLQEELENRTSET----------NTPQGNQEQLVTVMEE---RM 2040
             L L+    +  R+ Q L E LE   S T           T +  ++QL   + E   R 
Sbjct: 1657 KLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRD 1716

Query: 2041 IEVEQKLKLVKRLL---QEKVNQLKEQLCKNT-KADAMVKDLYVEN----AQLLKALEV- 2091
            +E +++LK+V   L   QE +++L+  + + T +   M KDL   N    AQ LK  E  
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL 1776

Query: 2092 ------TEQRQKTAEKKNYLLEEKIASLSNIVRNL 2120
                   +++Q+T +K   ++ EK   LSN+ ++L
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL 1811



 Score =  134 bits (337), Expect = 1e-30
 Identities = 298/1488 (20%), Positives = 615/1488 (41%), Gaps = 207/1488 (13%)

Query: 264  LKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQ 323
            LK H   ++ DE  R  +  +A       ++ +  D    H  ++  +    EE     Q
Sbjct: 1244 LKEH--QETIDELRRSVSEKTA-------QIINTQDLEKSHTKLQEEIPVLHEE-----Q 1289

Query: 324  EILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREK 383
            E+L  +    +    + EL L  E     TK+S     LA  + E   L E+  +   E 
Sbjct: 1290 ELLPNVKEVSETQETMNELELLTEQS--TTKDS---TTLARIEMERLRLNEKFQESQEEI 1344

Query: 384  EKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQ 443
            + L  + D  + +K  +  + D               +L E  +E +A ++    K+ + 
Sbjct: 1345 KSLTKERDNLKTIKEALEVKHD---------------QLKEHIRETLAKIQESQSKQEQS 1389

Query: 444  I-LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTN 502
            + +++   +  ++  E+E+ K +++ +  R+ + +   S+   E  +  + +A+ ++   
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALL-RIEIEMLGLSKRLQESHDEMKSVAKEKDDLQ 1448

Query: 503  KLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR---NEYERQCRVLQDQVDELQSELE 559
            +LQ  L++   +   ++    A+    EE L        E E     L+  + E ++E+ 
Sbjct: 1449 RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS 1508

Query: 560  EYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHH 619
              + Q   +   L+N   E  E              E+ N   +S   E V E  + + H
Sbjct: 1509 TIQKQLEAINDKLQNKIQEIYEKE------------EQFNIKQISEVQEKVNELKQFKEH 1556

Query: 620  RDICCLRLE-LEDKVRHYEKQLDETVVSCK---KAQENMKQRHENETHTLEKQISDLKNE 675
            R      L+ +E K+     +L E+    +   K +E MK+  E     L+ +   LK  
Sbjct: 1557 RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE----ALQIERDQLKEN 1612

Query: 676  IAELQGQAAVLKEAHHE---ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLT 732
              E+  +    +E  ++    T  +E ++K  +++  +E+   Q KL L++      RLT
Sbjct: 1613 TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ-KLNLENIETENIRLT 1671

Query: 733  QA-------QASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELR 785
            Q          S  +ER+ L+S    EE ++    +L++  +E +T  +EK    +EEL+
Sbjct: 1672 QILHENLEEMRSVTKERDDLRS---VEETLKVERDQLKENLRETITRDLEK----QEELK 1724

Query: 786  KELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELK 845
              ++  H +E QE  +K+    + +T++I     S+ QK  E    AL++ + + ++EL+
Sbjct: 1725 --IVHMHLKEHQETIDKLRGIVSEKTNEI-----SNMQKDLEHSNDALKAQDLKIQEELR 1777

Query: 846  ----DLQEQQR----------EEKSQWEFEKDELTQECAEAQELLKE---------TLKR 882
                 L+EQQ           E+  +    + +L    A+ QE ++E         TLK+
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK 1837

Query: 883  EKTTSLVLTQEREMLEKTYKEH---LNSMVVER----QQLLQDLEDLRNVSETQQSLLSD 935
            +   +     E E L+K  K+    L+ + +E     Q+L ++LE++++V + +     D
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER-----D 1892

Query: 936  QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM---EH----DQERQEMMSKLL 988
             +  ++ + K E  + +E L +  A +    Q L+   M   EH    D+ R+++  K +
Sbjct: 1893 NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952

Query: 989  AMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSML------------QSGC 1036
             + +I K      D+ + E+  +I  LQ K  ++ +    ++M             Q   
Sbjct: 1953 QISDIQK----DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEA 2008

Query: 1037 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATE--ISRLQQR 1094
            Q +  + V  D    L ++  + LEE    +++ +R   + +KE++KM  +  I+ L++ 
Sbjct: 2009 QNLSMQSVRMDN-FQLTKKLHESLEEIR--IVAKERDELRRIKESLKMERDQFIATLREM 2065

Query: 1095 LQK------LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE 1148
            + +      ++P   + S   +  TE       + +  L++             +  DLE
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE 2125

Query: 1149 DD-------EVRDLGSTGTSSVQRQEVK---IEESEASVEGFSELENSEETRTESWELKN 1198
             +        +R   +     +Q + ++         S+E    ++  +   +   ++K 
Sbjct: 2126 KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185

Query: 1199 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIP---EASPKYKLLYEDV 1255
            +  +   +  M   D     EK+++LL  +  L++   +  R     + +    L  E++
Sbjct: 2186 EQHESINKFEMDFID---EVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242

Query: 1256 SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVK 1315
             +  D  + E   ++T + + L N KE+T     L++ L    ++ +    ++K  D + 
Sbjct: 2243 LK--DFSESEFPSIKTEFQQVLSNRKEMTQF---LEEWLNTRFDIEKLKNGIQKENDRIC 2297

Query: 1316 IENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVP 1375
              N   N  ++ +  +  + +E          WE  L++L+ E +  + +  QTL+  + 
Sbjct: 2298 QVNNFFNNRIIAIMNESTEFEERSATISK--EWEQDLKSLK-EKNEKLFKNYQTLKTSLA 2354

Query: 1376 RVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQT--HQERPRVQNQVILEE 1433
                V+   ++ K  +          EK++  E + LH   ++  H+E   ++ Q  LE 
Sbjct: 2355 SGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENS-LHEAKESAMHKESKIIKMQKELEV 2413

Query: 1434 NTTLLGFQDKHFQHQATIAELE--LEKTK--LQELTRKL-------KERVTILVKQKDVL 1482
               ++       + QA + E    LEKTK  +Q L  K+       KE +  L K K V 
Sbjct: 2414 TNDIIA------KLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL-KMKLVK 2466

Query: 1483 SHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1542
               EK +  K    ++  T + ++ + E++R   E L++        + + + +   SN 
Sbjct: 2467 IDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNK 2526

Query: 1543 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1602
             L    GS      K   +K E+         L+K+IS+LK +N+QL  +  EL   N  
Sbjct: 2527 PLTCGGGSGIVQNTKALILKSEHI-------RLEKEISKLKQQNEQLIKQKNELLSNNQH 2579

Query: 1603 NQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL--ERCK 1648
               +++   +R  +    K+    NS    +     + K+++   +CK
Sbjct: 2580 LSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCK 2627



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 114/585 (19%), Positives = 230/585 (39%), Gaps = 64/585 (10%)

Query: 1544 LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQN 1603
            L  L  +    + K      E +  + +++  +K+I +LK + +++ LE    + +  Q 
Sbjct: 317  LTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQL 376

Query: 1604 QEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELS 1663
             + L+E                    L++ + EK    E L R  V SS+L    E +  
Sbjct: 377  AQLLEE-----------------KDLLQKVQNEKI---ENLTRMLVTSSSLTLQQELKAK 416

Query: 1664 EVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL 1723
              +  T  + + N +          +         +  I+ +   +E +  E +  S  L
Sbjct: 417  RKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTL 476

Query: 1724 NSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS 1783
            ++        S +E   AT    Q++ E +  SL++         + L    + + L++ 
Sbjct: 477  DTL-------SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL- 528

Query: 1784 RMKSDL-RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLD 1842
            + K+DL      E++  K + M L  ++ N   K+       +   L N+       K++
Sbjct: 529  KEKNDLDEFEALERKTKKDQEMQLIHEISNL--KNLVKHAEVYNQDLENELS----SKVE 582

Query: 1843 HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTE 1902
             L  +E Q+   +       ++N K +L++S E +        PK  K      T+   E
Sbjct: 583  LLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIED------PKQMKQ-----TLFDAE 631

Query: 1903 QEKLSLKRECDQFQKEQSPANRKVSQM----NSLEQELETIHLENEGLKKKQVKLDEQLM 1958
               L  KRE    + E      K+ ++      +E +++    + E  KK QV L+++L 
Sbjct: 632  TVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQ 691

Query: 1959 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE---L 2015
               +  +  T        D ++ +   C +    +   LQ++L +    N+ L+EE   L
Sbjct: 692  SAFNEITKLT-----SLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL 746

Query: 2016 ENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLL--QEKVNQLKEQLCKNTKADA 2073
                S  +  +  ++++    EE  I   +K KL   ++  + +V  L E++ K     A
Sbjct: 747  SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLA 806

Query: 2074 MVKDLYV---ENAQLLKALEVT-EQRQKTAEKKNYLLEEKIASLS 2114
              +  Y    +  Q  K L +  EQ+ K   ++N  + ++I +LS
Sbjct: 807  TTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLS 851


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1063 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1121 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1174

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1235 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1286

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1329

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1330 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1378

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1439 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1556

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1675

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1734

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1839

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1840 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2373

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2427

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1402

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1458

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1517

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2116

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2175

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2176 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2220

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2279

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2280 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2330

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2331 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2377

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2378 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2432

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2489

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2600

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2661 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2709



 Score =  172 bits (436), Expect = 3e-42
 Identities = 361/1721 (20%), Positives = 684/1721 (39%), Gaps = 278/1721 (16%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 970  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1028

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1089 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1149 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1385 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1503 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1556

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1853

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1910

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1971 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2028

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2443

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2444 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2482

Query: 1905 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2483 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2531

Query: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2024
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2532 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2557

Query: 2025 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQL
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1953 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2066

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2118

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2172

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2173 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2216

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2275

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2334

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2335 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2451 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2491

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2492 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2549

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2550 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2581

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2582 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2630

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2631 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2686 EDVR 2689



 Score =  115 bits (287), Expect = 6e-25
 Identities = 302/1468 (20%), Positives = 585/1468 (39%), Gaps = 204/1468 (13%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 968  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1081

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1142 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1184

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1185 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1354

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1412

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1413 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1463

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1698

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1815

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1816 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1923

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1924 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2037

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2214

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTP 2025
             AT +    +   Q+ ++     V  E+  +L+ ++   E  N+ L   L ++ +     
Sbjct: 2215 EATEAARQRS---QVEEELFSVRVQMEELSKLKARI---EAENRAL--ILRDKDNTQRFL 2266

Query: 2026 QGNQEQLVTVMEE--RMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLY--VE 2081
            Q   E++  V EE  R+    Q+   +++L +E + Q      +   A+ M+K+    V+
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ------QRALAEKMLKEKMQAVQ 2320

Query: 2082 NAQLLKA-LEVTEQRQKTAEKKNYLLEE 2108
             A  LKA  E+ +Q+++ A+++   L+E
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQE 2348


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1067 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1124

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1125 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1178

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1179 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1239 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1290

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1291 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1333

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1334 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1382

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1383 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1442

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1443 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1501

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1502 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1560

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1679

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1738

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1843

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1844 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2080

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2140

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2201 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2260

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2377

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2431

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2492 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2545

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2546 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1406

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1462

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1521

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1581

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1582 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1641

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1702 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1761

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1881

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1882 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2120

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2179

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2180 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2224

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2225 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2283

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2284 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2334

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2335 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2381

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2382 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2436

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2493

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2604

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2605 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2664

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2665 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2713



 Score =  172 bits (436), Expect = 3e-42
 Identities = 361/1721 (20%), Positives = 684/1721 (39%), Gaps = 278/1721 (16%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 974  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1032

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1033 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1092

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1093 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1152

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1153 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1269 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1328

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1329 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1388

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1389 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1507 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1560

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1740

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1741 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1800

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1801 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1857

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1914

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1975 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2032

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2447

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2448 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2486

Query: 1905 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2487 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2535

Query: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2024
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2536 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2561

Query: 2025 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQL
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2602



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1897 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1956

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1957 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2070

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2122

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2176

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2177 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2220

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2279

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2280 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2338

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2339 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2455 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2495

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2496 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2553

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2554 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2585

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2586 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2634

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2635 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2689

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2690 EDVR 2693



 Score =  115 bits (287), Expect = 6e-25
 Identities = 302/1468 (20%), Positives = 585/1468 (39%), Gaps = 204/1468 (13%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 972  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1029

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1030 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1085

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1086 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1145

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1146 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1188

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1189 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1358

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1359 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1416

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1417 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1467

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1468 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1527

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1587

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1647

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1702

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1819

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1820 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1927

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1928 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1985

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1986 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2041

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2218

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTP 2025
             AT +    +   Q+ ++     V  E+  +L+ ++   E  N+ L   L ++ +     
Sbjct: 2219 EATEAARQRS---QVEEELFSVRVQMEELSKLKARI---EAENRAL--ILRDKDNTQRFL 2270

Query: 2026 QGNQEQLVTVMEE--RMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLY--VE 2081
            Q   E++  V EE  R+    Q+   +++L +E + Q      +   A+ M+K+    V+
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ------QRALAEKMLKEKMQAVQ 2324

Query: 2082 NAQLLKA-LEVTEQRQKTAEKKNYLLEE 2108
             A  LKA  E+ +Q+++ A+++   L+E
Sbjct: 2325 EATRLKAEAELLQQQKELAQEQARRLQE 2352


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1063 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1121 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1174

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1235 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1286

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1329

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1330 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1378

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1439 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1556

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1675

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1734

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1839

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1840 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2373

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2427

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1402

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1458

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1517

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2116

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2175

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2176 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2220

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2279

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2280 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2330

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2331 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2377

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2378 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2432

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2489

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2600

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2661 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2709



 Score =  172 bits (436), Expect = 3e-42
 Identities = 361/1721 (20%), Positives = 684/1721 (39%), Gaps = 278/1721 (16%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 970  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1028

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1089 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1149 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1385 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1503 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1556

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1853

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1910

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1971 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2028

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2443

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2444 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2482

Query: 1905 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2483 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2531

Query: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2024
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2532 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2557

Query: 2025 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQL
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1953 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2066

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2118

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2172

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2173 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2216

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2275

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2334

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2335 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2451 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2491

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2492 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2549

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2550 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2581

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2582 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2630

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2631 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2686 EDVR 2689



 Score =  115 bits (287), Expect = 6e-25
 Identities = 302/1468 (20%), Positives = 585/1468 (39%), Gaps = 204/1468 (13%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 968  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1081

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1142 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1184

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1185 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1354

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1412

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1413 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1463

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1698

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1815

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1816 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1923

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1924 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2037

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2214

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTP 2025
             AT +    +   Q+ ++     V  E+  +L+ ++   E  N+ L   L ++ +     
Sbjct: 2215 EATEAARQRS---QVEEELFSVRVQMEELSKLKARI---EAENRAL--ILRDKDNTQRFL 2266

Query: 2026 QGNQEQLVTVMEE--RMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLY--VE 2081
            Q   E++  V EE  R+    Q+   +++L +E + Q      +   A+ M+K+    V+
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ------QRALAEKMLKEKMQAVQ 2320

Query: 2082 NAQLLKA-LEVTEQRQKTAEKKNYLLEE 2108
             A  LKA  E+ +Q+++ A+++   L+E
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQE 2348


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1031 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1088

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1089 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1142

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1143 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1203 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1254

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1255 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1297

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1298 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1346

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1347 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1406

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1407 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1465

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1466 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1524

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1643

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1702

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1807

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1808 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2044

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2104

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2165 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2224

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2341

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2395

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2456 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2509

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2510 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1370

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1426

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1485

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1545

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1546 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1605

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1666 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1725

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1845

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1846 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2084

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2143

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2144 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2188

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2189 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2247

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2248 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2298

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2299 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2345

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2346 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2400

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2401 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2457

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2568

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2569 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2628

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2629 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2677



 Score =  172 bits (436), Expect = 3e-42
 Identities = 361/1721 (20%), Positives = 684/1721 (39%), Gaps = 278/1721 (16%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 938  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 996

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 997  AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1056

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1057 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1116

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1117 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1233 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1292

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1293 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1352

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1353 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1471 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1524

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1704

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1705 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1764

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1765 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1821

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1878

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1939 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 1996

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2411

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2412 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2450

Query: 1905 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2451 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2499

Query: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2024
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2500 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2525

Query: 2025 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQL
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2566



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1861 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1920

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1921 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2034

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2086

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2140

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2141 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2184

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2243

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2244 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2302

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2303 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2419 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2459

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2460 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2517

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2518 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2549

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2550 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2598

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2599 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2653

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2654 EDVR 2657



 Score =  115 bits (287), Expect = 6e-25
 Identities = 302/1468 (20%), Positives = 585/1468 (39%), Gaps = 204/1468 (13%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 936  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 993

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 994  QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1049

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1050 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1109

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1110 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1152

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1153 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1322

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1323 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1380

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1381 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1431

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1432 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1491

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1551

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1611

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1666

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1783

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1784 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1891

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1892 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1949

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1950 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2005

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2182

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTP 2025
             AT +    +   Q+ ++     V  E+  +L+ ++   E  N+ L   L ++ +     
Sbjct: 2183 EATEAARQRS---QVEEELFSVRVQMEELSKLKARI---EAENRAL--ILRDKDNTQRFL 2234

Query: 2026 QGNQEQLVTVMEE--RMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLY--VE 2081
            Q   E++  V EE  R+    Q+   +++L +E + Q      +   A+ M+K+    V+
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ------QRALAEKMLKEKMQAVQ 2288

Query: 2082 NAQLLKA-LEVTEQRQKTAEKKNYLLEE 2108
             A  LKA  E+ +Q+++ A+++   L+E
Sbjct: 2289 EATRLKAEAELLQQQKELAQEQARRLQE 2316


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1200 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1257

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1258 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1311

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1312 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1372 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1423

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1424 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1466

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1467 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1515

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1516 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1576 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1634

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1635 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1693

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1812

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1871

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1976

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1977 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2213

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2273

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2334 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2393

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2510

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2564

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2625 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1539

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1595

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1654

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1714

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1715 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1774

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1835 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1894

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 2014

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 2015 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2253

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2312

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2313 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2357

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2358 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2416

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2417 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2467

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2468 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2514

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2515 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2569

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2626

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2737

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2738 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2797

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2798 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2846



 Score =  172 bits (436), Expect = 3e-42
 Identities = 361/1721 (20%), Positives = 684/1721 (39%), Gaps = 278/1721 (16%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 1107 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1165

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1166 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1225

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1226 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1285

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1286 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1402 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1461

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1462 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1521

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1522 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1640 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1693

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1873

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1874 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1933

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1934 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1990

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 2047

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 2108 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2165

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2580

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2581 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2619

Query: 1905 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2620 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2668

Query: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2024
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2669 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2694

Query: 2025 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQL
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2735



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 2089

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 2090 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2203

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2255

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2309

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2310 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2353

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2412

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2413 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2471

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2472 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2588 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2628

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2629 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2686

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2687 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2718

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2719 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2767

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2768 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2822

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2823 EDVR 2826



 Score =  115 bits (287), Expect = 6e-25
 Identities = 302/1468 (20%), Positives = 585/1468 (39%), Gaps = 204/1468 (13%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 1105 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1162

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1163 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1218

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1219 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1279 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1321

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1322 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1491

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1492 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1549

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1550 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1600

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1601 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1660

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1720

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1780

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1835

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1952

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1953 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 2060

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 2061 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2118

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 2119 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2174

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2351

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTP 2025
             AT +    +   Q+ ++     V  E+  +L+ ++   E  N+ L   L ++ +     
Sbjct: 2352 EATEAARQRS---QVEEELFSVRVQMEELSKLKARI---EAENRAL--ILRDKDNTQRFL 2403

Query: 2026 QGNQEQLVTVMEE--RMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLY--VE 2081
            Q   E++  V EE  R+    Q+   +++L +E + Q      +   A+ M+K+    V+
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ------QRALAEKMLKEKMQAVQ 2457

Query: 2082 NAQLLKA-LEVTEQRQKTAEKKNYLLEE 2108
             A  LKA  E+ +Q+++ A+++   L+E
Sbjct: 2458 EATRLKAEAELLQQQKELAQEQARRLQE 2485


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1041 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1098

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1099 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1152

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1153 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1213 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1264

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1265 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1307

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1308 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1356

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1357 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1417 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1475

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1476 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1534

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1653

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1712

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1817

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1818 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2054

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2351

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2405

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2466 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2520 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1380

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1436

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1495

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1555

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1556 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1615

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1676 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1735

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1796 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1855

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1856 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2094

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2153

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2154 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2198

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2199 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2257

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2258 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2308

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2309 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2355

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2356 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2410

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2411 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2467

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2578

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2579 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2638

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2639 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2687



 Score =  172 bits (436), Expect = 3e-42
 Identities = 361/1721 (20%), Positives = 684/1721 (39%), Gaps = 278/1721 (16%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 948  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1006

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1007 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1066

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1067 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1126

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1127 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1242

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1243 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1302

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1303 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1362

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1363 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1481 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1534

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1714

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1715 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1774

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1775 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1831

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1888

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1949 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2006

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2421

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2422 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2460

Query: 1905 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2461 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2509

Query: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2024
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2510 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2535

Query: 2025 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQL
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2576



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1930

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1931 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2044

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2096

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2150

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2151 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2194

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2253

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2254 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2312

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2313 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2429 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2469

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2470 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2527

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2528 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2559

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2560 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2608

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2609 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2663

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2664 EDVR 2667



 Score =  115 bits (287), Expect = 6e-25
 Identities = 302/1468 (20%), Positives = 585/1468 (39%), Gaps = 204/1468 (13%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 946  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1003

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1004 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1059

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1060 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1120 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1162

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1163 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1332

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1333 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1390

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1391 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1441

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1442 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1501

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1561

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1621

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1676

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1793

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1794 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1901

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1902 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1959

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1960 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2015

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2192

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTP 2025
             AT +    +   Q+ ++     V  E+  +L+ ++   E  N+ L   L ++ +     
Sbjct: 2193 EATEAARQRS---QVEEELFSVRVQMEELSKLKARI---EAENRAL--ILRDKDNTQRFL 2244

Query: 2026 QGNQEQLVTVMEE--RMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLY--VE 2081
            Q   E++  V EE  R+    Q+   +++L +E + Q      +   A+ M+K+    V+
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ------QRALAEKMLKEKMQAVQ 2298

Query: 2082 NAQLLKA-LEVTEQRQKTAEKKNYLLEE 2108
             A  LKA  E+ +Q+++ A+++   L+E
Sbjct: 2299 EATRLKAEAELLQQQKELAQEQARRLQE 2326


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1049 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1106

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1107 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1160

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1221 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1272

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1273 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1315

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1316 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1364

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1365 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1424

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1425 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1483

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1484 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1542

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1661

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1662 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1720

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1781 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1825

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1826 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1883

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2062

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2122

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2183 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2359

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2413

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2474 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2527

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2528 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1271 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1330

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1388

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1444

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1503

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1563

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1564 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1623

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1683

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1684 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1743

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1744 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1804 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1863

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1864 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2102

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2161

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2162 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2206

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2207 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2265

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2266 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2316

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2317 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2363

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2364 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2418

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2419 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2475

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2586

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2587 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2646

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2647 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2695



 Score =  172 bits (436), Expect = 3e-42
 Identities = 361/1721 (20%), Positives = 684/1721 (39%), Gaps = 278/1721 (16%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 956  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1014

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1015 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1074

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1075 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1134

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1135 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1251 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1310

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1311 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1370

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1371 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1489 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1542

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1722

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1723 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1782

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1783 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1839

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1896

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1957 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2014

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2429

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2430 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2468

Query: 1905 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2469 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2517

Query: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2024
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2518 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2543

Query: 2025 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQL
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2584



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1879 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1938

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1939 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2052

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2104

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2105 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2158

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2159 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2202

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2261

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2262 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2320

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2321 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2437 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2477

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2478 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2535

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2536 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2567

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2568 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2616

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2617 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2671

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2672 EDVR 2675



 Score =  115 bits (287), Expect = 6e-25
 Identities = 302/1468 (20%), Positives = 585/1468 (39%), Gaps = 204/1468 (13%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 954  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1011

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1012 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1067

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1068 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1127

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1128 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1170

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1171 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1340

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1341 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1398

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1399 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1449

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1450 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1509

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1569

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1629

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1684

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1801

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1802 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1909

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1910 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1967

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1968 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2023

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2200

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTP 2025
             AT +    +   Q+ ++     V  E+  +L+ ++   E  N+ L   L ++ +     
Sbjct: 2201 EATEAARQRS---QVEEELFSVRVQMEELSKLKARI---EAENRAL--ILRDKDNTQRFL 2252

Query: 2026 QGNQEQLVTVMEE--RMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLY--VE 2081
            Q   E++  V EE  R+    Q+   +++L +E + Q      +   A+ M+K+    V+
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ------QRALAEKMLKEKMQAVQ 2306

Query: 2082 NAQLLKA-LEVTEQRQKTAEKKNYLLEE 2108
             A  LKA  E+ +Q+++ A+++   L+E
Sbjct: 2307 EATRLKAEAELLQQQKELAQEQARRLQE 2334


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 346  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 401
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1090 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1147

Query: 402  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1148 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1201

Query: 460  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 512
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1202 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261

Query: 513  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1262 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1313

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1314 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1356

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 689
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1357 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1405

Query: 690  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 732
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1406 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1465

Query: 733  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 782
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1466 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1524

Query: 783  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1525 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1583

Query: 838  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 890
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643

Query: 891  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1702

Query: 951  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1761

Query: 1011 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1065
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821

Query: 1066 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1123
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1866

Query: 1124 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1182
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1867 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924

Query: 1183 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1234
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984

Query: 1235 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1291
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044

Query: 1292 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1343
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2103

Query: 1344 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1385
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2163

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1443
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223

Query: 1444 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1476
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2224 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2283

Query: 1477 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1519
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343

Query: 1520 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2400

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2454

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1697
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1754
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2515 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568

Query: 1755 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2569 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1371

Query: 438  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1429

Query: 489  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 548
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1485

Query: 549  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1544

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 657
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1604

Query: 658  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1605 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1664

Query: 717  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 765
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1724

Query: 766  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 807
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1725 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1784

Query: 808  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 858
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1785 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844

Query: 859  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 912
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1845 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1904

Query: 913  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 947
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1905 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964

Query: 948  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 998
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024

Query: 999  ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1048
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2143

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1158
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2202

Query: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2203 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2247

Query: 1219 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2248 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2306

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1333
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2307 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2357

Query: 1334 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1393
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2358 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2404

Query: 1394 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1452
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2405 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2459

Query: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2460 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2516

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576

Query: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2627

Query: 1630 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1674
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2628 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2687

Query: 1675 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1716
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2688 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2736



 Score =  172 bits (436), Expect = 3e-42
 Identities = 361/1721 (20%), Positives = 684/1721 (39%), Gaps = 278/1721 (16%)

Query: 531  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 579
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 997  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1055

Query: 580  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 628
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1056 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1115

Query: 629  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 667
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1116 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1175

Query: 668  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 726
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1176 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231

Query: 727  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 780
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1291

Query: 781  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 831
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1292 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1351

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1352 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1411

Query: 892  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 942
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1412 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469

Query: 943  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 999
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1530 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1583

Query: 1060 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643

Query: 1119 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1155
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703

Query: 1156 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1207
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1763

Query: 1208 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1248
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1764 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1823

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1824 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1880

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1367
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1937

Query: 1368 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1423
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997

Query: 1424 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1472
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1998 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2055

Query: 1473 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1521
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1639
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231

Query: 1640 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1677
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291

Query: 1678 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1728
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351

Query: 1729 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1784
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2470

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2471 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2509

Query: 1905 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2510 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2558

Query: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2024
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2559 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2584

Query: 2025 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQL
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 320  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 373
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1980 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035

Query: 434  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2093

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2145

Query: 535  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 591
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2146 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2199

Query: 592  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 650
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2200 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2243

Query: 651  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2302

Query: 706  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2303 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2361

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 809
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2362 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417

Query: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 867
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477

Query: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2478 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2518

Query: 928  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2519 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2576

Query: 986  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2577 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2608

Query: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2609 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2657

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2658 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2712

Query: 1166 QEVK 1169
            ++V+
Sbjct: 2713 EDVR 2716



 Score =  115 bits (287), Expect = 6e-25
 Identities = 302/1468 (20%), Positives = 585/1468 (39%), Gaps = 204/1468 (13%)

Query: 758  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 995  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1052

Query: 818  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1053 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1108

Query: 877  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 928
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1109 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1168

Query: 929  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 987
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1169 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1211

Query: 988  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1042
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1212 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264

Query: 1043 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1095
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324

Query: 1096 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1381

Query: 1137 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1194
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1382 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1439

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1254
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1440 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1490

Query: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1310
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1491 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1550

Query: 1311 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1343
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1610

Query: 1344 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1401
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1670

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1725

Query: 1462 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1517
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1842

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1636
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1843 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1950

Query: 1697 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1748
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1951 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2008

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 2009 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2064

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1851
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124

Query: 1852 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1906
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184

Query: 1907 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2241

Query: 1966 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTP 2025
             AT +    +   Q+ ++     V  E+  +L+ ++   E  N+ L   L ++ +     
Sbjct: 2242 EATEAARQRS---QVEEELFSVRVQMEELSKLKARI---EAENRAL--ILRDKDNTQRFL 2293

Query: 2026 QGNQEQLVTVMEE--RMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLY--VE 2081
            Q   E++  V EE  R+    Q+   +++L +E + Q      +   A+ M+K+    V+
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ------QRALAEKMLKEKMQAVQ 2347

Query: 2082 NAQLLKA-LEVTEQRQKTAEKKNYLLEE 2108
             A  LKA  E+ +Q+++ A+++   L+E
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQE 2375


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score =  172 bits (435), Expect = 4e-42
 Identities = 330/1666 (19%), Positives = 713/1666 (42%), Gaps = 212/1666 (12%)

Query: 394  EKLKSLMASEVDDHH---AAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK 450
            ++LK   + E+DDH    + ++  ++  L ++   ++E ++  +  + +E E +LQQ G 
Sbjct: 219  KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERI-EELENLLQQGGS 277

Query: 451  QRLELE-QEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509
              +E +  +I + +     ++     S K+  +LE+++ +  +KL+  EN  + L+R  E
Sbjct: 278  GVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQE 337

Query: 510  NVLAEK-------------FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQS 556
             +  EK                L PS+ +   Q + +T+      +   V  ++V  LQ 
Sbjct: 338  QLNVEKRQIMEECENLKLECSKLQPSAVK---QSDTMTEKERILAQSASV--EEVFRLQQ 392

Query: 557  ELEEYRAQGRVLRLPLKNSPSEEVEANSG------GIEPEHGLGSEECNPLNMSI-EAEL 609
             L +  A+  ++RL   N  +   E N         +E E  L S+E   L MS+ +   
Sbjct: 393  ALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450

Query: 610  VIEQMKEQHHRDICC------LRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETH 663
              E +K    RDI        LRL LE K +   + + E      + +E  +Q  E   H
Sbjct: 451  EYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKH 510

Query: 664  TLEKQISDLKNEIAELQGQA-AVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ 722
             +      +K+++++ Q +  +++ +   +      +EKK++  +LE++K  + ++L +Q
Sbjct: 511  MIL-----IKDQLSKQQNEGDSIISKLKQDLN----DEKKRVH-QLEDDKMDITKELDVQ 560

Query: 723  HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 782
             E  +++ +        +++         E+KV  L  +L +  +  ++  ++K  LE  
Sbjct: 561  KEKLIQSEVALNDLHLTKQK--------LEDKVENLVDQLNKSQESNVS--IQKENLEL- 609

Query: 783  ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQ 842
               KE + +++ EL   R ++    N+ ++   + F+    K  ER E+ +++L+     
Sbjct: 610  ---KEHIRQNEEELSRIRNELMQSLNQDSN---SNFKDTLLK--ER-EAEVRNLKQNL-S 659

Query: 843  ELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 902
            EL+ L E  ++     + E ++L   C + +  L+E L                      
Sbjct: 660  ELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGN------------------- 700

Query: 903  EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASE 962
               N + +E+  +++ L+  +   E +      ++LE  + +++ + E         ++ 
Sbjct: 701  ---NQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSAL 757

Query: 963  QLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD---RERAEMSTEISRLQSKI 1019
            QL  + L +L  + D E  E+   +  M+  HK T +       E+ +++  I++ +  I
Sbjct: 758  QLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFI 817

Query: 1020 KEMQQATSPL-SMLQSGCQVIGEEEV------EGDGALSLLQQGEQLLEENGDVLLSLQR 1072
            +++++ +S L   L    Q + + E+      E D +L  +++    L+E  + L   Q 
Sbjct: 818  EKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS 877

Query: 1073 -----AHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFL 1127
                 A  + +    ++A+E+S+L    + LE  +     + E   +    +  Q    L
Sbjct: 878  RTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ----SKMQLLQSL 933

Query: 1128 QQNRTK------QVEGVTRRHVLSDLE-DDEVRDLGST-----GTSSVQRQEVKIEESE- 1174
            Q+ + +      Q E +   H    LE D+E++ L  T          +RQ+++ + S+ 
Sbjct: 934  QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDI 993

Query: 1175 --------ASVEGFSELENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKK 1221
                     ++E  SE  +  +  TE       E + +I  L E+ + L    D+ S+ +
Sbjct: 994  FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDE 1053

Query: 1222 QDLLFDVSVLKKKLK---MLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALE 1278
               L  + + +K L+   +  RI   S    ++Y         LQ++L+      ++   
Sbjct: 1054 VGKLTQI-IQQKDLEIQALHARISSTSHTQDVVY---------LQQQLQAYAMEREKVFA 1103

Query: 1279 NNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQES 1338
               E T E   L+ E  KM ++     + E +  +++ EN++L+    R +   + +   
Sbjct: 1104 VLNEKTRENSHLKTEYHKMMDIV---AAKEAALIKLQDENKKLST---RFESSGQDMFRE 1157

Query: 1339 VVQRCDCCLWEASLE----NLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYL 1394
             +Q     + E  +E    + + +    +LQ + T  E    V S  +  EE  QE   L
Sbjct: 1158 TIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNE-AGGVNS--NQFEELLQERDKL 1214

Query: 1395 EGNTQLLEKVKAHEIAWL----HGTIQTHQERPRVQNQVILE-ENTTLL-----GFQDKH 1444
            +   + +E+ K   +  +    H + Q  +E  ++Q QV+++ +N + L     G    +
Sbjct: 1215 KQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSY 1274

Query: 1445 FQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSE 1504
             Q++  +     E  ++Q    +L     +L+ + D++S    +    +++      C  
Sbjct: 1275 EQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIIS---PQLSSASLLTPQSAECLR 1331

Query: 1505 MQQKVELLRYESEKLQQENSILRNE-------ITTLNEED-SISNLKLGTLNGSQEEMWQ 1556
               K E+L   SE LQQE   LR         I TL E +  +S+    T    ++E  Q
Sbjct: 1332 -ASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQ 1390

Query: 1557 KTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTE 1616
                +KQ       + + LK++   +K K+ QL   N   + K ++N E L++    L E
Sbjct: 1391 TDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNEN-ELLRQAVTNLKE 1449

Query: 1617 MLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQEN 1676
             +   E + G    E  +  +    +E E   +Q + +  S+   L E + + H + +E 
Sbjct: 1450 RILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSM--MLREKEFECHSM-KEK 1506

Query: 1677 HLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL 1736
             L  ++L K K+  +  +L+   Q +++V S  EK +  ++   + + +   K  +++ L
Sbjct: 1507 ALAFEQLLKEKEQGKTGELN---QLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTAL 1563

Query: 1737 EHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEK 1796
            ++ +  ++ ++     +   L++ L+ S       ED+     L     ++ LR   ++ 
Sbjct: 1564 QNEVQRLRDKEFRSNQELERLRNHLLES-------EDSYTREALAAEDREAKLR---KKV 1613

Query: 1797 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1856
              L+++++S    ++NA  ++ + ++ +    L+   K+     L   +++EQ       
Sbjct: 1614 TVLEEKLVSSSNAMENASHQA-SVQVESLQEQLNVVSKQRDETALQLSVSQEQV------ 1666

Query: 1857 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNP--TEQEKLSLKRECDQ 1914
            ++    + N +  L H +++ + + S  L K QK L      N    E + +SL+   D+
Sbjct: 1667 KQYALSLANLQMVLEHFQQEEKAMYSAELEK-QKQLIAEWKKNAENLEGKVISLQECLDE 1725

Query: 1915 FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEM 1960
                   A+R   Q++  E+++E +  +NE  ++    + ++LM +
Sbjct: 1726 ANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSL 1771



 Score =  165 bits (417), Expect = 5e-40
 Identities = 319/1554 (20%), Positives = 644/1554 (41%), Gaps = 207/1554 (13%)

Query: 657  RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
            RH  +T   +   +  ++EI +LQ     LK+   +    H+ E   LQ   +++ T + 
Sbjct: 192  RHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEIS 251

Query: 717  EKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK 776
                                   R RE L      EE++    +ELE   Q+  + ++E 
Sbjct: 252  ----------------------RRHREELSD---YEERI----EELENLLQQGGSGVIET 282

Query: 777  HTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSL 836
               +  E++K  ++  Q E  E  +KME            Q +   + + ++  SA    
Sbjct: 283  DLSKIYEMQK-TIQVLQIEKVESTKKME------------QLEDKIKDINKKLSSAEND- 328

Query: 837  EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREM 896
                R  L+  QEQ   EK Q   E + L  EC++ Q          K +  +  +ER +
Sbjct: 329  ----RDILRREQEQLNVEKRQIMEECENLKLECSKLQP------SAVKQSDTMTEKERIL 378

Query: 897  LEKTYKEHLNSMVVERQQLLQDLED--LRNVSETQQSLLSDQILELKSSHKRELREREEV 954
             +    E     V   QQ L D E+  +R  S  Q + L++  L+LK   + E+ E+E+ 
Sbjct: 379  AQSASVEE----VFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM--RIEVLEKEKS 432

Query: 955  LCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRER------AEM 1008
            L      E   S  L +L  E++  +      +     +H        +E+      +E 
Sbjct: 433  LLSQEKEELQMS--LLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEK 490

Query: 1009 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQG--------EQLL 1060
             T I+ ++   ++ Q+AT  + +++     + +++ EGD  +S L+Q          QL 
Sbjct: 491  ETLIAEIEELDRQNQEATKHMILIK---DQLSKQQNEGDSIISKLKQDLNDEKKRVHQLE 547

Query: 1061 EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
            ++  D+   L    E+ ++  V     ++ L    QKLE    + + +D+       N +
Sbjct: 548  DDKMDITKELDVQKEKLIQSEV----ALNDLHLTKQKLED--KVENLVDQLNKSQESNVS 601

Query: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEAS--VE 1178
             Q E    +   +Q E       LS + ++ ++ L     S+ +   +K  E+E     +
Sbjct: 602  IQKENLELKEHIRQNE-----EELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQ 656

Query: 1179 GFSELEN-SEETRTESWELKNQISQLQEQLMMLCADCDRASEK----KQDLLFDVSVLKK 1233
              SELE  +E  +  ++++K +     E+L++ C D     E+       L  + + + +
Sbjct: 657  NLSELEQLNENLKKVAFDVKME----NEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVE 712

Query: 1234 KLKM------------LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNK 1281
             LKM             +R+ E + KY+   E++S   +     L++    ++  ++ N+
Sbjct: 713  TLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQL---EHEHLIKLNQ 769

Query: 1282 ELTAEVFRLQDELKKME-EVTETFLSLEKSYDEVKIENEELN---VLVLRLQGKIEKLQE 1337
            +   E+  L+  +++M+ +  ET   L  S +E K   + +N   + + +L+ +  KLQE
Sbjct: 770  KKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQE 829

Query: 1338 SVVQRCDCCLWEASLENLEIEPD---GNILQLNQTLEECVPRVRSVHHVIEECKQENQYL 1394
             + +          L     E D   G++ + N  L+E + R+R      EE  +     
Sbjct: 830  ELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR------EEQSRTAPVA 883

Query: 1395 EGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAEL 1454
            +  T       A E++ L+ TI+ H E     +Q I+E         D++      +  L
Sbjct: 884  DPKTLDSVTELASEVSQLN-TIKEHLEEEIKHHQKIIE---------DQNQSKMQLLQSL 933

Query: 1455 ELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRY 1514
            + +K ++ E  R   E++     Q  +    EK+EE+K++   ++   +++ ++ + ++ 
Sbjct: 934  QEQKKEMDEF-RYQHEQMNATHTQLFL----EKDEEIKSLQKTIEQIKTQLHEERQDIQT 988

Query: 1515 ESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVEN 1574
            ++  + QE  +    I   +E+  +S  +   L    +E   + + + ++N ++ K ++ 
Sbjct: 989  DNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQ 1048

Query: 1575 LKK-QISELKIKNQQLDLENTELSQK--NSQNQEKLQELNQRLTEMLCQKEKEPGNSALE 1631
            L K ++ +L    QQ DLE   L  +  ++ + + +  L Q+L     ++EK    + L 
Sbjct: 1049 LSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKV--FAVLN 1106

Query: 1632 EREQEKFNLKEELERCKVQSSTLVSSLEAELSEV-----KIQTHIVQQENHLLKDELEKM 1686
            E+ +E  +LK E  +       +V++ EA L ++     K+ T        + ++ ++ +
Sbjct: 1107 EKTRENSHLKTEYHK----MMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNL 1162

Query: 1687 KQLHRCPD--LSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMK 1744
             ++ R  D  +    QK  ++L+  +      EA     N   + L +   L+ ++  M+
Sbjct: 1163 SRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKME 1222

Query: 1745 QEQ-------KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQM---------SRMKSD 1788
            + +       ++ +H+SA L+ +L   Q + Q L D+  N  LQ+          + ++ 
Sbjct: 1223 EWKQQVMTTVQNMQHESAQLQEEL--HQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETK 1280

Query: 1789 LRVTQQEKEALKQEVMSLHKQLQNAGGK--SWAPEIATHPSGLHNQQKRLSWDKLDHLMN 1846
            L+   QE   ++  +  L        GK    +P++++  S L  Q           +++
Sbjct: 1281 LKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSS-ASLLTPQSAECLRASKSEVLS 1339

Query: 1847 EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL 1906
            E  +LL QE E L+  +Q   A +   +E   +L  ++    +           T+ E  
Sbjct: 1340 ESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH---EQTDSEIK 1396

Query: 1907 SLKRECDQFQK----EQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLM---- 1958
             LK + D  QK    +      K  Q+ S  +       ENE L++    L E+++    
Sbjct: 1397 QLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEM 1456

Query: 1959 ---EMQHLRSTATPSPSPHAWDLQLLQQ--QACPMVPREQFLQLQRQLLQAERINQHLQE 2013
               +++        +      + Q LQ+      M+ RE+  +      +A    Q L+E
Sbjct: 1457 DIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKE 1516

Query: 2014 ELENRTSE----TNTPQGNQEQLVTVMEER---MIEVEQKLKLVKRLLQEKVNQLKE-QL 2065
            + + +T E     N  +  QE+ V   +ER   M+ ++QK ++    LQ +V +L++ + 
Sbjct: 1517 KEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQK-QMENTALQNEVQRLRDKEF 1575

Query: 2066 CKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVRN 2119
              N + + +   L        +     E R+    KK  +LEEK+ S SN + N
Sbjct: 1576 RSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMEN 1629



 Score =  161 bits (407), Expect = 7e-39
 Identities = 376/1844 (20%), Positives = 731/1844 (39%), Gaps = 311/1844 (16%)

Query: 430  IAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLE 489
            +A+L  ++    + +L +  +   E+E E+  ++T+E  I    A+   EN RL+    +
Sbjct: 23   LASLTGQISNFTKDMLMEGTE---EVEAELPDSRTKE--IEAIHAILRSENERLKKLCTD 77

Query: 490  NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQD 549
              EK    E    +   +  N L +K  ++    A                 RQ   LQD
Sbjct: 78   LEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKA-----------------RQI-ALQD 119

Query: 550  QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAEL 609
            Q+ +LQS  +   +   V   P   + S    + + GI        ++       I ++ 
Sbjct: 120  QLLKLQSAAQSVPSGAGV---PATTASS----SFAYGISHHPSAFHDDDMDFGDIISSQQ 172

Query: 610  VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQI 669
             I ++  +  R        LE +V H+       +    KAQ       ++E   L+  I
Sbjct: 173  EINRLSNEVSR--------LESEVGHWRH-----IAQTSKAQ-GTDNSDQSEICKLQNII 218

Query: 670  SDLKN----EIAELQGQAAVLKEAHH----EATCRHEEEKKQLQVKLEEEKTHLQEKLRL 721
             +LK     EI + Q + +VL+ AH     E + RH EE    + ++EE +  LQ+    
Sbjct: 219  KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSG 278

Query: 722  QHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 781
              E +L       +     + E ++S+    +K+  L  +++  +++  ++  ++  L +
Sbjct: 279  VIETDLSKIYEMQKTIQVLQIEKVEST----KKMEQLEDKIKDINKKLSSAENDRDILRR 334

Query: 782  EELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYR 841
            E+   E L   +R++ E  E ++ EC++   Q  A  QSD     ER  +   S+E  +R
Sbjct: 335  EQ---EQLNVEKRQIMEECENLKLECSKL--QPSAVKQSDTMTEKERILAQSASVEEVFR 389

Query: 842  --QELKDLQ--------------------------EQQREEKSQWEFEKDELTQECAEAQ 873
              Q L D +                          E   +EKS    EK+EL     +  
Sbjct: 390  LQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLN 449

Query: 874  ---ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQ 930
               E++K T  R+ +    L   R  LE   +E LN  + E++ L+ ++E+L    + Q 
Sbjct: 450  NEYEVIKSTATRDISLDSELHDLRLNLEAKEQE-LNQSISEKETLIAEIEEL----DRQN 504

Query: 931  SLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLE-------MEHDQERQEM 983
               +  ++ +K    ++  E + ++ +         +R+ +LE        E D +++++
Sbjct: 505  QEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKL 564

Query: 984  MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSM--LQSGCQVIGE 1041
            +   +A+ ++H          + ++  ++  L  ++ + Q++   +    L+    +   
Sbjct: 565  IQSEVALNDLHLT--------KQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN 616

Query: 1042 EEVEGDGALSLLQQGEQLLEEN-GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP 1100
            EE        L+Q   Q    N  D LL  + A  + +K+N+   +E+ +L + L+K+  
Sbjct: 617  EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNL---SELEQLNENLKKVAF 673

Query: 1101 GLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGT 1160
             + M +   E       +   Q E  L  N    +E  T    L         + G    
Sbjct: 674  DVKMEN---EKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLK-------MEKGEIEA 723

Query: 1161 SSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQ------------ISQLQEQLM 1208
                 ++  +EE+    +   EL N+    T + +L+++            I++L++ + 
Sbjct: 724  ELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIE 783

Query: 1209 MLCADCDRASEKKQDLLFD----VSVLKKKLKMLERIPEASPKYKL---LYEDVSRENDC 1261
             +  D     +     L +      ++ KK   +E++ E S K +     Y    R+N+ 
Sbjct: 784  QMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEI 843

Query: 1262 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1321
            L++ +   +       E N  L  E+ RL++E  +   V +       S  E+  E  +L
Sbjct: 844  LRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADP--KTLDSVTELASEVSQL 901

Query: 1322 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1381
            N +   L+ +I+  Q+ +  +                 + + +QL Q+L+E    +    
Sbjct: 902  NTIKEHLEEEIKHHQKIIEDQ-----------------NQSKMQLLQSLQEQKKEMDEFR 944

Query: 1382 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTI-----QTHQERPRVQ---NQVILEE 1433
            +      Q  Q    +TQL  + K  EI  L  TI     Q H+ER  +Q   + +  E 
Sbjct: 945  Y------QHEQMNATHTQLFLE-KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQET 997

Query: 1434 NTTLLGFQDKHFQHQATIAELE--LEKTKLQELTRKL-KERVTILVKQKDVLSHGE---- 1486
                L  ++   +H  + AE E  ++  K +EL  KL  E+   L KQ D LS  E    
Sbjct: 998  KVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKL 1057

Query: 1487 ----KEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1542
                ++++L+      +I+ +   Q V  L+ + +    E    R ++  +  E +  N 
Sbjct: 1058 TQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME----REKVFAVLNEKTRENS 1113

Query: 1543 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE-LSQKNS 1601
             L T      E  +  + V  + AA+ K+ +  KK  +  +   Q +  E  + LS+   
Sbjct: 1114 HLKT------EYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR 1167

Query: 1602 QNQEKLQELNQRLTEMLCQKE-KEPGNSA-------LEEREQEKFNLKEE---LERCKVQ 1650
            +   ++  L+Q+   +L   +    GN A        EE  QE+  LK++   +E  K Q
Sbjct: 1168 EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQ 1227

Query: 1651 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-------QLHRCPD--LSDFQQK 1701
              T V +++ E ++++ + H +Q +  +  D   K++       Q +   +  L +F Q+
Sbjct: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287

Query: 1702 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKS--WEHQSASLKS 1759
            ++ V     +L   K+ L  +L+    +L+ +SLL  + A   +  KS      S  L+ 
Sbjct: 1288 LAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQ 1347

Query: 1760 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWA 1819
            +L   ++ +Q  + T++ +     R+   +  T + +    ++  S  KQL+        
Sbjct: 1348 ELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK-------- 1399

Query: 1820 PEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ--ENERLQTMVQNTK---------- 1867
             E       L  ++  L   K D L++  +    +  ENE L+  V N K          
Sbjct: 1400 -EKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDI 1458

Query: 1868 AELTHSREKV----RQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQ-----KE 1918
             +L    EK+    R  E+      + ++  S  +   E E  S+K +   F+     KE
Sbjct: 1459 GKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKE 1518

Query: 1919 QSPA---NRKVSQMNSLEQELETIHLENE----GLKKKQVKLDEQLMEMQHLRSTATPSP 1971
            Q      N+ ++ + S++++      E +     LK+KQ++      E+Q LR       
Sbjct: 1519 QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRD------ 1572

Query: 1972 SPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQ 2031
                                ++F   Q    + ER+  HL E  ++ T E    +  + +
Sbjct: 1573 --------------------KEFRSNQ----ELERLRNHLLESEDSYTREALAAEDREAK 1608

Query: 2032 L---VTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTK-----------ADAMVKD 2077
            L   VTV+EE+++     ++        +V  L+EQL   +K           +   VK 
Sbjct: 1609 LRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQ 1668

Query: 2078 LYVENAQLLKALEVTEQRQKT-----AEKKNYLLEEKIASLSNI 2116
              +  A L   LE  +Q +K       EK+  L+ E   +  N+
Sbjct: 1669 YALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENL 1712



 Score =  151 bits (381), Expect = 8e-36
 Identities = 309/1497 (20%), Positives = 631/1497 (42%), Gaps = 194/1497 (12%)

Query: 359  QAALASFKAEIRHL--LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD-HHAAIERRN 415
            Q AL+  + EI  L  L + + +  +  KL+  ++  EK KSL++ E ++   + ++  N
Sbjct: 391  QQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450

Query: 416  EYNLRKLDEEYKERIAALKNELR---KEREQILQQAGKQRLELEQEIEKAKTEENYIRDR 472
            EY + K        + +  ++LR   + +EQ L Q+  ++  L  EIE+   +       
Sbjct: 451  EYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKH 510

Query: 473  LALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEER 532
            + L   + S+ +NE      KL +  N   K    LE+   +   +LD       +Q+E+
Sbjct: 511  MILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELD-------VQKEK 563

Query: 533  LTQMR---NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEP 589
            L Q     N+     + L+D+V+ L  +L +              S    V      +E 
Sbjct: 564  LIQSEVALNDLHLTKQKLEDKVENLVDQLNK--------------SQESNVSIQKENLEL 609

Query: 590  EHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKK 649
            +  +   E     +  E    + Q    + +D   L  E E +VR+ ++ L E       
Sbjct: 610  KEHIRQNEEELSRIRNELMQSLNQDSNSNFKD--TLLKEREAEVRNLKQNLSE------- 660

Query: 650  AQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
                ++Q +EN    L+K   D+K E  +L       ++  H+      EE      +L 
Sbjct: 661  ----LEQLNEN----LKKVAFDVKMENEKL---VLACEDVRHQL-----EECLAGNNQLS 704

Query: 710  EEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ 769
             EK  + E L+++ + E++A L  A+     E    + +       R L     Q   E 
Sbjct: 705  LEKNTIVETLKME-KGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEH 763

Query: 770  LTSLVEKHTLEKEELRKELLEKHQRELQEGREKMET--ECNRRTSQIEAQFQSDCQKVTE 827
            L  L +K  +E  EL+K  +E+   + +E ++ + +  E  ++ +Q+  + +   +K+ E
Sbjct: 764  LIKLNQKKDMEIAELKKN-IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKE 822

Query: 828  RCESALQSLEGRYRQELK--DLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKR--- 882
            R  S LQ    +Y Q L+  ++  Q  EEK +      E      E  E L+E   R   
Sbjct: 823  R-SSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAP 881

Query: 883  ---EKTTSLVLTQEREMLE-KTYKEHLNSMVVERQQLLQD-----LEDLRNVSETQQSL- 932
                KT   V     E+ +  T KEHL   +   Q++++D     ++ L+++ E ++ + 
Sbjct: 882  VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941

Query: 933  -LSDQILELKSSHKRELRER-EEVLCQAGASEQLASQ-RLERLEMEHDQER--QEMMSKL 987
                Q  ++ ++H +   E+ EE+       EQ+ +Q   ER +++ D     QE   + 
Sbjct: 942  EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQS 1001

Query: 988  LAMEN------IHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSG--CQVI 1039
            L +EN      + KA  E   +   E   EI  L  K   + +    LS  + G   Q+I
Sbjct: 1002 LNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQII 1061

Query: 1040 GEEEVE-------------GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMAT 1086
             ++++E                 + L QQ +    E   V   L     +  +EN  + T
Sbjct: 1062 QQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVL----NEKTRENSHLKT 1117

Query: 1087 EISRLQQRLQKLEPGLV--------MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGV 1138
            E  ++   +   E  L+        +S+  +    + F  T +     +++ +  +++ +
Sbjct: 1118 EYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIRE-KDIEIDAL 1176

Query: 1139 TRR--HVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWEL 1196
            +++   +L+ L+     +  + G +S Q +E+  E  +   +     E  ++  T    +
Sbjct: 1177 SQKCQTLLAVLQTSSTGN-EAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNM 1235

Query: 1197 KNQISQLQEQLMMLCA----DCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1252
            +++ +QLQE+L  L A    D D  S+ + D    +   ++    L+   +   + +   
Sbjct: 1236 QHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSI 1295

Query: 1253 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYD 1312
              +    D L  +L ++  +   A     + +AE  R      K E ++E+   L++  +
Sbjct: 1296 GQLCNTKDLLLGKLDIISPQLSSASLLTPQ-SAECLR----ASKSEVLSESSELLQQELE 1350

Query: 1313 EVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIE-PDGNILQLNQTLE 1371
            E++   +E +  +  LQ    +L +S+          + LE  E E  D  I QL +  +
Sbjct: 1351 ELRKSLQEKDATIRTLQENNHRLSDSIAA-------TSELERKEHEQTDSEIKQLKEK-Q 1402

Query: 1372 ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRV------ 1425
            + + ++     ++ + K + Q L  N     KV  +E+  L   +   +ER  +      
Sbjct: 1403 DVLQKLLKEKDLLIKAKSD-QLLSSNENFTNKVNENEL--LRQAVTNLKERILILEMDIG 1459

Query: 1426 ----QNQVILE----ENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVK 1477
                +N+ I+E    + T     Q+ + +    + E E E   ++E     ++    L+K
Sbjct: 1460 KLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQ----LLK 1515

Query: 1478 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEED 1537
            +K+    GE  + L A+    + T    Q++ +++    +K Q EN+ L+NE+  L +++
Sbjct: 1516 EKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQK-QMENTALQNEVQRLRDKE 1574

Query: 1538 SISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1597
              SN +L  L   +  + +  ++  +E  A +     L+K+++ L+ K     L ++  +
Sbjct: 1575 FRSNQELERL---RNHLLESEDSYTREALAAEDREAKLRKKVTVLEEK-----LVSSSNA 1626

Query: 1598 QKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSS 1657
             +N+ +Q  +Q   + L E L        N   ++R++    L    E+ K Q +  +++
Sbjct: 1627 MENASHQASVQV--ESLQEQL--------NVVSKQRDETALQLSVSQEQVK-QYALSLAN 1675

Query: 1658 LEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKE 1717
            L+  L       H  Q+E  +   ELEK KQL     ++++++   ++     K++  +E
Sbjct: 1676 LQMVLE------HFQQEEKAMYSAELEKQKQL-----IAEWKKNAENL---EGKVISLQE 1721

Query: 1718 ALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDT 1774
             L +E N+ +D    +S L  ++   +++ +  + Q+   +  L   Q+K+ +L ++
Sbjct: 1722 CL-DEANAALD---SASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANS 1774



 Score =  141 bits (355), Expect = 8e-33
 Identities = 301/1442 (20%), Positives = 581/1442 (40%), Gaps = 251/1442 (17%)

Query: 319  IENSQEILKAL---DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLER 375
            + N  E++K+    D SLD  ++   L L  + + L    S  +  +A  +   R   E 
Sbjct: 448  LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEA 507

Query: 376  VDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKN 435
               ++  K++L    ++ + + S +  +++D    + +  +  +    E   ++   +++
Sbjct: 508  TKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQS 567

Query: 436  ELRKEREQILQQAGKQRLE-LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL 494
            E+      + +Q  + ++E L  ++ K++ E N    +  L LKE+ R   E        
Sbjct: 568  EVALNDLHLTKQKLEDKVENLVDQLNKSQ-ESNVSIQKENLELKEHIRQNEE-------- 618

Query: 495  AEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFLQEERLTQMRNEYERQCRVLQD--- 549
             E   + N+L ++L       F D  L    AE    ++ L+++    E   +V  D   
Sbjct: 619  -ELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKM 677

Query: 550  -------QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLN 602
                     ++++ +LEE  A    L L  KN+  E ++   G IE E  L   +   L 
Sbjct: 678  ENEKLVLACEDVRHQLEECLAGNNQLSLE-KNTIVETLKMEKGEIEAE--LCWAKKRLLE 734

Query: 603  MSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 662
             + + E  IE++    + +   L+LE E  ++  +K+ D  +   KK  E M   H+   
Sbjct: 735  EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK-DMEIAELKKNIEQMDTDHKETK 793

Query: 663  HTL------EKQISDLKNE----IAELQGQAAVLKE---AHHEATCRHE------EEKKQ 703
              L      +KQ++ L N+    I +L+ +++ L+E    + +A  ++E      EEK +
Sbjct: 794  DVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDR 853

Query: 704  LQVKLEEEKTHLQEKL-RLQHEM----------------ELKARLTQAQASFEREREGL- 745
                ++EE  HLQE+L RL+ E                 EL + ++Q     E   E + 
Sbjct: 854  SLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIK 913

Query: 746  ----------QSSAWTEEKVRGLTQELEQF--HQEQLTSLVEKHTLEKEELRKEL---LE 790
                      QS     + ++   +E+++F    EQ+ +   +  LEK+E  K L   +E
Sbjct: 914  HHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973

Query: 791  KHQRELQEGREKMETECNRRTSQIEAQF--------QSDCQKV-TERCESALQSLEGRYR 841
            + + +L E R+ ++T+ +    + + Q         + D  K  TER    ++  E    
Sbjct: 974  QIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE---- 1029

Query: 842  QELKDLQEQQREEKSQW-EFEKDEL--------------------------TQECAEAQE 874
             E+K L E+      Q  +  KDE+                          TQ+    Q+
Sbjct: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089

Query: 875  LLKE-TLKREKTTSLV--LTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS 931
             L+   ++REK  +++   T+E   L+  Y + ++ +  +   L++  ++ + +S   +S
Sbjct: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149

Query: 932  LLSDQILELKSSHKRELREREEVL------CQ-----------AGASEQLASQRLERLEM 974
               D   E   +  R +RE++  +      CQ              +  + S + E L  
Sbjct: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209

Query: 975  EHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1034
            E D+ +Q+ + K+   +     T +    E A++  E+ +LQ+++       S L     
Sbjct: 1210 ERDKLKQQ-VKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKL----- 1263

Query: 1035 GCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR 1094
                    +V+  G +   +Q E  L+  G  L  +Q +  Q       +      L  +
Sbjct: 1264 --------QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ-------LCNTKDLLLGK 1308

Query: 1095 LQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRD 1154
            L  + P L  +S L   + E     A ++E   + +   Q E    R  L + +D  +R 
Sbjct: 1309 LDIISPQLSSASLLTPQSAECL--RASKSEVLSESSELLQQELEELRKSLQE-KDATIRT 1365

Query: 1155 LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADC 1214
            L        Q    ++ +S A+    SELE  E  +T+S E+K Q+ + Q+ L  L  + 
Sbjct: 1366 L--------QENNHRLSDSIAAT---SELERKEHEQTDS-EIK-QLKEKQDVLQKLLKEK 1412

Query: 1215 DRASEKKQD-LLFDVSVLKKKLKMLERIPEASPKYK----LLYEDVSR---ENDCLQEEL 1266
            D   + K D LL        K+   E + +A    K    +L  D+ +   EN+ + E  
Sbjct: 1413 DLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY 1472

Query: 1267 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1326
            R  ET Y    E N + +  +   + E   M+E    F  L K  ++ K    ELN    
Sbjct: 1473 RGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGK--TGELN---- 1526

Query: 1327 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEE 1386
            +L   ++ +QE  V               + E D  +L L Q   E       V  + ++
Sbjct: 1527 QLLNAVKSMQEKTVV-------------FQQERDQVMLALKQKQMENTALQNEVQRLRDK 1573

Query: 1387 CKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV-ILEENTTLLGFQDKHF 1445
              + NQ LE   +L   +   E ++    +       +++ +V +LEE         ++ 
Sbjct: 1574 EFRSNQELE---RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENA 1630

Query: 1446 QHQATIAELELEKTKLQELTRKLKERVTILVKQKD--VLSHGEKEEELK---AMMHDLQI 1500
             HQA++                L+E++ ++ KQ+D   L     +E++K     + +LQ+
Sbjct: 1631 SHQASVQ------------VESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQM 1678

Query: 1501 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1560
                 QQ+ E   Y +E  +Q+  I   +    N E  + +L+               E 
Sbjct: 1679 VLEHFQQE-EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQ---------------EC 1722

Query: 1561 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1620
            + + NAA    +++  +   +L +K +Q++    EL ++N   QE L ++ ++L  +   
Sbjct: 1723 LDEANAA----LDSASRLTEQLDVKEEQIE----ELKRQNELRQEMLDDVQKKLMSLANS 1774

Query: 1621 KE 1622
             E
Sbjct: 1775 SE 1776


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  171 bits (433), Expect = 7e-42
 Identities = 379/1927 (19%), Positives = 784/1927 (40%), Gaps = 241/1927 (12%)

Query: 368  EIRHLLERVDQVVREKEKLRSDLD-KAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEY 426
            ++ H L+ +   + +K++   DL  + E L+ L+ S+     A++    ++    L  + 
Sbjct: 734  DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK----DASLVTNEDHQRSLLAFDQ 789

Query: 427  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
            +  +      +  E+  +  +  + RLE +Q  + +   +N + D L  SL+   ++ ++
Sbjct: 790  QPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRV-DSLEFSLESQKQMNSD 848

Query: 487  LLENAEKLA----EYENLTNKLQRNLENVLAEKFGDL----DPSSAEFFLQEERLTQMRN 538
            L +  E+L     E E    K ++  ++ +AE    +    + +SA   +  E L+ + N
Sbjct: 849  LQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALEN 908

Query: 539  EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSP--SEEVEANSGGIEPEHGLGSE 596
            + E++ ++L D+V+  Q+E++E +    +L   LK     SE +      +     L   
Sbjct: 909  K-EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKR 967

Query: 597  ECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 656
            E   L         I     Q   ++        + +   EK + E     K+ +  + Q
Sbjct: 968  EIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQ 1027

Query: 657  RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
            R E   +  E    DL  +    Q + + L+   +E T   E  K +L+   E      Q
Sbjct: 1028 RCEETGNAYE----DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ 1083

Query: 717  EKL-----------RLQHEME-----LKARLTQAQASFEREREGLQSSAWT--------E 752
            E L            L  E+E     L++ +T  Q + + E  GL+    T        +
Sbjct: 1084 EFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQ 1143

Query: 753  EKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQ---------EGREKM 803
            ++V  L QE EQ  +   T   E   LE E +R  + E+     Q         E +E  
Sbjct: 1144 KEVNDLLQENEQLMKVMKTKH-ECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEIS 1202

Query: 804  ETECNRRTSQIEAQFQS------DCQKVTERCESALQSLEGRYR-QELKDLQEQQREEKS 856
                N +  Q+EA  ++      + +K  E  +  LQ++ G      L+D+Q Q+     
Sbjct: 1203 LDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLK 1262

Query: 857  QWEFEKDEL-----------TQECAEAQELLKETLKR----EKTTSLVLTQEREMLEKTY 901
              E + +E              + A  Q  L+ T+ +    EK   ++  ++ E++ +  
Sbjct: 1263 DCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELN 1322

Query: 902  KEHLNSMVVER---QQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQA 958
                  +   R   +++ + L +++ +++    L  + + ++      E    +  +  A
Sbjct: 1323 DSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLA 1382

Query: 959  GASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSK 1018
               E  + + L   + E      E+  K L++++ HK   +    +  +MS+++S LQ+ 
Sbjct: 1383 PLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHD----QHCQMSSKMSELQTY 1438

Query: 1019 IKEMQQATSPLSMLQSGCQ-------VIGEEE----------VEGDGALSLLQQGE---Q 1058
            +  ++     LS      Q        +G EE          V    +LS L        
Sbjct: 1439 VDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRA 1498

Query: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEI---SRLQQRLQKLEPGLVMSSCLDEPAT-- 1113
            LLE+ GD  +SL    E AV  N     E+   S  ++ L + E     +  ++E  +  
Sbjct: 1499 LLEQTGD--MSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLC 1556

Query: 1114 EFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEES 1173
            E +  + E+ E  ++     + + +     L   E  E+  L     S  ++ + K+  +
Sbjct: 1557 EVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKL--T 1614

Query: 1174 EASVEGFSELENSEETRTESWELKNQISQLQEQLM------MLCADCDRASEKKQDLLFD 1227
              ++E  S+L  +E+ +TE   L+ ++++LQ Q +      +L  D + A + + +   D
Sbjct: 1615 SVTLEMESKLA-AEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESC-D 1672

Query: 1228 VSVLKKKLKMLERIP----------EASPKYKLLYEDVSREN------DCLQEELRMMET 1271
            +S  +   +  ER P          +A     L  E ++         +C  E+    +T
Sbjct: 1673 ISK-EHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQ--SPDT 1729

Query: 1272 RYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGK 1331
             Y+   E+  + ++E             V   FL  ++    +++  +E +   LRL   
Sbjct: 1730 NYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789

Query: 1332 IEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1391
            IE     V    +       ++ L+ +     +QL   +E C+     +  ++ E K+EN
Sbjct: 1790 IEDRDRKVESLLN------EMKELDSKLHLQEVQLMTKIEACI----ELEKIVGELKKEN 1839

Query: 1392 QYLE--------GNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLG--FQ 1441
              L          + +LL++V+  E   L+  ++ H ++   ++   + +N   +   ++
Sbjct: 1840 SDLSEKLEYFSCDHQELLQRVETSE--GLNSDLEMHADKSSRED---IGDNVAKVNDSWK 1894

Query: 1442 DKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQIT 1501
            ++    +  ++ +  EK  ++     L+  + ++  +K  L   EK+ E K  +    I 
Sbjct: 1895 ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCL---EKDNENKQKV----IV 1947

Query: 1502 CSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETV 1561
            C  +++++ ++  E  +L+ E   +  + T L++       K   L   Q E     +  
Sbjct: 1948 C--LEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVA 2005

Query: 1562 KQENAAVQKMVENLKKQISEL-------KIKNQQLDLENTELSQKNSQNQEKLQELNQRL 1614
            + E     ++++ L   +SEL       + K Q L+ ++  LS    + + ++ +LN+  
Sbjct: 2006 EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKE- 2064

Query: 1615 TEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ 1674
             + L  KE E   + L E + EK N+ + LE   V+       L +   EV    H +++
Sbjct: 2065 -KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEV----HQLRR 2119

Query: 1675 --ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCV----- 1727
              E   ++ E ++ KQLH    L + +++  S+    E L +E + +SEE    V     
Sbjct: 2120 GIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQ-MSEENQELVILDAE 2178

Query: 1728 DKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKS 1787
            +  A+   L+ +I  M +  K +E    +L+S+     +++Q  +  +  ++  +S  KS
Sbjct: 2179 NSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKS 2238

Query: 1788 DLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK--RLSWDKLDHLM 1845
             L   +Q +  +K+E  +  + LQN        E+    + L   Q+  + +   LD  +
Sbjct: 2239 LLEEKEQAEIQIKEESKTAVEMLQNQ-----LKELNEAVAALCGDQEIMKATEQSLDPPI 2293

Query: 1846 NEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLE--SNLLPKHQKHLNPSGTMNPTEQ 1903
             EE QL     E+L+  ++  + +     +++++ E  ++LL    ++L     +  T Q
Sbjct: 2294 EEEHQLR-NSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2352

Query: 1904 EKLSLKRECDQFQKEQSPANRK--VSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQ 1961
            E  +L+ E  + + E   A  +     +  LE ++ TI  E E L  +  K  E++ E++
Sbjct: 2353 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2412

Query: 1962 HLRST-----------ATPSPSPHAWDLQLLQ----------------QQACPMVPREQF 1994
             + S+                   +  +++LQ                Q+AC    +EQ 
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA--KEQN 2470

Query: 1995 LQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLL 2054
            L  Q + L+ E+    L + L+   +     Q +   L+  +E+   ++E+K + + RL 
Sbjct: 2471 LSSQVECLELEKAQ--LLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLK 2528

Query: 2055 QEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVT-EQRQKTAEKKNYLLEEKIASL 2113
             +  +Q  EQL            L+ E    L+ L V  EQ+ +  + KN  L++ +  L
Sbjct: 2529 NQIQDQ--EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVL 2586

Query: 2114 SNIVRNL 2120
             +  +NL
Sbjct: 2587 QSSYKNL 2593



 Score =  163 bits (412), Expect = 2e-39
 Identities = 378/1794 (21%), Positives = 731/1794 (40%), Gaps = 293/1794 (16%)

Query: 326  LKALDFSLDG-NINLTELTLALEN-ELLVTKNSIHQAALASFKAEIRHLLERVDQVVREK 383
            L+  + SLD  N  L +L   L N EL + ++   +  L      IR  LE  +    + 
Sbjct: 1196 LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQS 1255

Query: 384  EKLRS----DLDKAEKLKS----LMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKN 435
            +++      ++D  EK  S    L  S+ D+ H     +   N     E+  E + A K 
Sbjct: 1256 QEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKY 1315

Query: 436  ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLA 495
            EL  E      +      ++ +E+ K   E   + D       ++  L  EL+E+     
Sbjct: 1316 ELVTELNDSRSECITATRKMAEEVGKLLNEVKILND-------DSGLLHGELVEDIPG-G 1367

Query: 496  EYENLTNKLQRNLENVLAEK--FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQ--- 550
            E+    N+        L E   +  L  S  E  +    L +     + + ++L DQ   
Sbjct: 1368 EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQ 1427

Query: 551  ----VDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG---SEECNPLNM 603
                + ELQ+ ++  +A+  VL   L+N   + V+    G+  E GL    S  C P + 
Sbjct: 1428 MSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL--EEGLVPSLSSSCVPDSS 1485

Query: 604  SIEA-------ELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 656
            S+ +         ++EQ  +        L   LE  V   +  +DE  V C   QE    
Sbjct: 1486 SLSSLGDSSFYRALLEQTGDM------SLLSNLEGAVSANQCSVDE--VFCSSLQEENLT 1537

Query: 657  RHENET-----------------HTLEKQISDLKNE----IAELQGQAAVLKEAHHEATC 695
            R E  +                  +LEK    ++++      E+Q    +L     E  C
Sbjct: 1538 RKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDC 1597

Query: 696  RHEE---EKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW-- 750
              ++   E +Q Q KL      ++ KL  + +   +  L    A  + +   L S +   
Sbjct: 1598 LRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLG 1657

Query: 751  --TEEKVRGLTQ--ELEQFHQEQLTSLVEKHTLEK---EELRKELLEKHQRELQEGREKM 803
              TE+ ++G  +  ++ + H  + T    KH + +   ++ +++L    ++  + G  K 
Sbjct: 1658 IDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKP 1717

Query: 804  ETECNRRTS---------QIEAQFQSDC----------------------------QKVT 826
              EC+   S         + + Q  S+C                             +V 
Sbjct: 1718 TGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK 1777

Query: 827  ERCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDEL---TQECAEAQELLKETL 880
            E     L+ L   E R R +++ L  + +E  S+   ++ +L    + C E ++++ E L
Sbjct: 1778 ETSNENLRLLHVIEDRDR-KVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGE-L 1835

Query: 881  KREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILEL 940
            K+E +    L+++ E     ++E L   V   + L  DLE   +  ++ +  + D + ++
Sbjct: 1836 KKENSD---LSEKLEYFSCDHQE-LLQRVETSEGLNSDLE--MHADKSSREDIGDNVAKV 1889

Query: 941  KSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHK-ATCE 999
              S K    + E  L +  + +  AS   E L +E D E  +     L  +N +K     
Sbjct: 1890 NDSWKERFLDVENELSRIRSEK--ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV 1947

Query: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGDGALSLLQQGEQ 1058
              + E + +++E ++L+ ++  M + T+ L  L    +   +E E      L  +Q  E 
Sbjct: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA 2007

Query: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1118
             ++E  ++L +L       V E +K  T +    Q L+K    L ++ C           
Sbjct: 2008 EVKEKTELLQTL----SSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC----------- 2052

Query: 1119 TAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVE 1178
              E      Q N+ K++       + + L + +   L      S   +   +E+ E ++ 
Sbjct: 2053 --ELENQIAQLNKEKELLVKESESLQARLSESDYEKL----NVSKALEAALVEKGEFALR 2106

Query: 1179 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFD-VSVLKKKLKM 1237
              S  E   + R    +L+ +I +  E+  +  A+  +  E++ D L D V  L+++L+M
Sbjct: 2107 LSSTQEEVHQLRRGIEKLRVRI-EADEKKQLHIAEKLKERERENDSLKDKVENLERELQM 2165

Query: 1238 LERIPEA----SPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDE 1293
             E   E     +   K   E +  + + +   L++ E          + LT ++   Q +
Sbjct: 2166 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ 2225

Query: 1294 LKKMEEVTETFLSL--EKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRC-DCCLWEA 1350
            L +++++  +F SL  EK   E++I+ EE    V  LQ ++++L E+V   C D  + +A
Sbjct: 2226 LSELDKLLSSFKSLLEEKEQAEIQIK-EESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284

Query: 1351 SLENLE--IEPD----GNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1404
            + ++L+  IE +     +I +L   LE    +   V   ++E +     L+G  + LE  
Sbjct: 2285 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE-- 2342

Query: 1405 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQEL 1464
            +  EIA      +T+QE   ++      EN+                 E+E  K K++ +
Sbjct: 2343 RELEIA------RTNQEHAALE-----AENSK---------------GEVETLKAKIEGM 2376

Query: 1465 TRKLK----ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1520
            T+ L+    + VTI  +++++ +  +KE+E    + +L+I  S  +  ++    E  +++
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQE---RISELEIINSSFENILQEKEQEKVQMK 2433

Query: 1521 QENS----ILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1576
            +++S    +L+ ++  LNE       ++  L+  QE              A +   +NL 
Sbjct: 2434 EKSSTAMEMLQTQLKELNE-------RVAALHNDQE--------------ACKAKEQNLS 2472

Query: 1577 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQE 1636
             Q+       + L+LE  +L Q   + +     L   +  ++  +E E G   LE++++E
Sbjct: 2473 SQV-------ECLELEKAQLLQGLDEAKNNYIVLQSSVNGLI--QEVEDGKQKLEKKDEE 2523

Query: 1637 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD---ELEKMKQLHRCP 1693
               LK +++        LVS    +LS+V+ +  + +++N  L++   ELE+  Q+ +  
Sbjct: 2524 ISRLKNQIQ----DQEQLVS----KLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSK 2575

Query: 1694 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1753
            + S  Q  +  + S  + L  E E    +  S V+K+ K +  E     +++E      +
Sbjct: 2576 NAS-LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE---TELQREMHEMAQK 2631

Query: 1754 SASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1813
            +A L+ +L  S EK   L   +Q +  ++   K  L+    E   LK+ +  +HK     
Sbjct: 2632 TAELQEEL--SGEK-NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEK 2688

Query: 1814 GGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1873
             GK    EIA +   LH  +K+             Q LL   N++ +  +Q  + +LT  
Sbjct: 2689 EGKV-REEIAEYQLRLHEAEKK------------HQALLLDTNKQYEVEIQTYREKLTSK 2735

Query: 1874 RE--KVRQLESNLLPKHQKHLNPS-----GTMNPTEQEKLSLKRECDQFQKEQSPANRK- 1925
             E    ++LE +LL   ++ LN S       +   ++ K+   +  +Q +KE   A  K 
Sbjct: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795

Query: 1926 ---VSQMNSLEQELETIHLENEGLKKKQ----------VKLDEQLMEMQHLRST 1966
               +     LE+E E +  E   L+  Q           K+DE   E++ L+ T
Sbjct: 2796 KLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKET 2849



 Score =  160 bits (406), Expect = 1e-38
 Identities = 396/1924 (20%), Positives = 769/1924 (39%), Gaps = 243/1924 (12%)

Query: 320  ENSQEILKAL-DFSLDGNINLTELTLALEN-----ELLVTKNSIHQAALASFKAEIRHLL 373
            E SQ I K   D S   N+ + E   ALEN     +LL  K    QA +   K    HLL
Sbjct: 880  ETSQRISKLQEDTSAHQNV-VAETLSALENKEKELQLLNDKVETEQAEIQELKKS-NHLL 937

Query: 374  ERV--------DQVVREKEKLRS--DLDKAE---------KLKSLMASEVDDHHAAIERR 414
            E          + +  EK+++ S   L+K E          LK + AS ++     + ++
Sbjct: 938  EDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINAS-LNQEKMNLIQK 996

Query: 415  NEYNLRKLDEEYKERIAALKNELRKEREQILQ---QAGKQRLELEQEIEKAKTEENYIRD 471
            +E     +DE  K  I+ L ++ ++E+  +LQ   + G    +L Q+ + A+ + + +  
Sbjct: 997  SESFANYIDEREKS-ISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLEC 1055

Query: 472  RL--ALSLKENSRLENELLENA---------EKLAEYENLTNKLQRNLENVL----AEKF 516
             L    SL EN + E E L+ A          KLA  E     L   LE V     +E  
Sbjct: 1056 LLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115

Query: 517  GDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRL---PLK 573
             + + S +E    ++ +  ++ E  +  + + D + E +  ++  + +     L   P++
Sbjct: 1116 DNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIR 1175

Query: 574  NSPSE-EVEANSGGIEPEHGLGSEEC-----NPLNMSIEAELVIEQMK-EQHHRDICCLR 626
            NS  E E E N    +P+  L  +E      N   + +EA L  +++K ++  ++  CL+
Sbjct: 1176 NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ 1235

Query: 627  LELED-----KVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG 681
             EL+      +  + +    + +   K  + + ++++ +  H L    +D  +    LQ 
Sbjct: 1236 HELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQT 1295

Query: 682  QAAVLKEAHHEATCRH-EEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFER 740
                L E   E  C   + EK +L  +L + ++   E +    +M  +      +     
Sbjct: 1296 TMNKLNEL--EKICEILQAEKYELVTELNDSRS---ECITATRKMAEEVGKLLNEVKILN 1350

Query: 741  EREGLQSSAWTEEKVRG-LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG 799
            +  GL      E+   G   ++  + H   L  L E ++ E   L  + ++ H  ELQE 
Sbjct: 1351 DDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEK 1410

Query: 800  REKMETE--------CNRRTSQIEAQFQSDCQKVTERCESA-LQSLEGRYRQELKDLQEQ 850
               +++E        C   +   E Q   D  K      S  L++ +G   +E++   E+
Sbjct: 1411 FLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEE 1470

Query: 851  QREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREM------LEKTYKEH 904
                        D  +          +  L++    SL+   E  +      +++ +   
Sbjct: 1471 GLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSS 1530

Query: 905  LNSMVVERQQL-------LQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQ 957
            L    + R++        +++LE L  V       L +++        +E++E E++L  
Sbjct: 1531 LQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLL-- 1588

Query: 958  AGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1017
            +   ++L   R + L  E++Q +Q++ S  L ME+  K   E    E+  +  E++RLQ 
Sbjct: 1589 SSERQELDCLRKQYLS-ENEQWQQKLTSVTLEMES--KLAAEKKQTEQLSLELEVARLQL 1645

Query: 1018 KIKEMQQAT-------SPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENG--DVLL 1068
            +  ++   +         +      C  I +E        +      Q+ +++   D+ L
Sbjct: 1646 QGLDLSSRSLLGIDTEDAIQGRNESCD-ISKEHTSETTERTPKHDVHQICDKDAQQDLNL 1704

Query: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPG-----LVMSSCLDEPA---------TE 1114
             +++  E      VK   E S  Q      EP         S C+ E +          +
Sbjct: 1705 DIEKITETGA---VKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMD 1761

Query: 1115 FFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESE 1174
            F GN  +     L+   T   E +   HV+ D  D +V  L     + ++  + K+   E
Sbjct: 1762 FLGNQEDIHNLQLRVKETSN-ENLRLLHVIED-RDRKVESL----LNEMKELDSKLHLQE 1815

Query: 1175 ASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK 1234
              V+  +++E   E      ELK + S L E+L     D        Q+LL  V   +  
Sbjct: 1816 --VQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCD-------HQELLQRVETSEGL 1866

Query: 1235 LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL 1294
               LE   + S +  +  ++V++ ND  +E    +E            +  E   L+ +L
Sbjct: 1867 NSDLEMHADKSSREDI-GDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADL 1925

Query: 1295 KKMEEVTETFLSLEKSYDE----VKIENEELNVLVL---RLQGKIEKLQESVVQRCDCCL 1347
               E V    L LEK  +     +    EEL+V+     +L+G+++ + +          
Sbjct: 1926 ---EVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTT------- 1975

Query: 1348 WEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAH 1407
               +L+ L  +      +L     EC+  ++     ++E  +  Q L  +   L K K H
Sbjct: 1976 ---ALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTH 2032

Query: 1408 EIAWLHGTIQTHQE----RPRVQNQVI-LEENTTLLGFQDKHFQHQATIAELELEKTKLQ 1462
                L    +  Q     +  ++NQ+  L +   LL  + +  Q  A ++E + EK  + 
Sbjct: 2033 LQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ--ARLSESDYEKLNVS 2090

Query: 1463 E-LTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1521
            + L   L E+    ++   + S  E+  +L+  +  L++     ++K   +  + ++ ++
Sbjct: 2091 KALEAALVEKGEFALR---LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERER 2147

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
            EN  L++++  L  E          L  S+E   Q+   +  EN+  +  VE LK QI E
Sbjct: 2148 ENDSLKDKVENLERE----------LQMSEEN--QELVILDAENSKAE--VETLKTQIEE 2193

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLK 1641
            +    +  +L+   L  +     +++QE   +L+E+   K      S LEE+EQ +  +K
Sbjct: 2194 MARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL--DKLLSSFKSLLEEKEQAEIQIK 2251

Query: 1642 EELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQK 1701
            EE       S T V  L+ +L E+      +  +  ++K   + +      P + +  Q 
Sbjct: 2252 EE-------SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD-----PPIEEEHQL 2299

Query: 1702 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1761
             +S+    EKL    EA  E+   CV +  K S  EH    +K   ++ E +    ++  
Sbjct: 2300 RNSI----EKLRARLEA-DEKKQLCVLQQLKES--EHHADLLKGRVENLERELEIARTNQ 2352

Query: 1762 VASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPE 1821
              +  + +N +  V+ +  ++  M   LR  + +   ++ E  +L  +LQ    +    E
Sbjct: 2353 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2412

Query: 1822 IATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLE 1881
            I                   ++++ E++Q   Q  E+  T ++  + +L    E+V  L 
Sbjct: 2413 IIN--------------SSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALH 2458

Query: 1882 SNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHL 1941
            ++      K  N S  +   E EK  L +  D+ +          S +N L QE+E    
Sbjct: 2459 NDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQ---SSVNGLIQEVEDGKQ 2515

Query: 1942 ENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHA-WDLQLLQQQACPMVPREQFLQLQRQ 2000
            + E   ++  +L  Q+ + + L S  +     H  W  Q L+ +   +   ++   LQ +
Sbjct: 2516 KLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSK 2575

Query: 2001 LLQAERINQHLQEELENRTSETNTPQGNQEQLV----------TVMEERMIEVEQKLKLV 2050
                +   + LQ   +N  +E    + ++   V          T ++  M E+ QK   +
Sbjct: 2576 NASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAEL 2635

Query: 2051 KRLLQEKVNQLKEQL------CKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNY 2104
            +  L  + N+L  +L       K++K    +K+L +EN++L K+L+   + Q   EK+  
Sbjct: 2636 QEELSGEKNRLAGELQLLLEEIKSSKDQ--LKELTLENSELKKSLDCMHKDQ--VEKEGK 2691

Query: 2105 LLEE 2108
            + EE
Sbjct: 2692 VREE 2695



 Score =  156 bits (395), Expect = 2e-37
 Identities = 385/1932 (19%), Positives = 782/1932 (40%), Gaps = 269/1932 (13%)

Query: 311  LDTWQEEGIENSQEILKALDFSLDGNINLT----ELTLALENELLVTKNSIHQAA----- 361
            L+  +E   +  QE L  L F+ + N NL      +  AL +E+   +N+    A     
Sbjct: 1071 LEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130

Query: 362  -LASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIE-RRNEYNL 419
             + + K E   + + V+ +++E E+L   +    + ++L +  + +     E  RN+ N 
Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNF 1190

Query: 420  R-KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS-L 477
            + ++D E KE      N    + E +L+    +  E E+E E  + E   IR  L  S L
Sbjct: 1191 KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNL 1250

Query: 478  KENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR 537
            ++    E   L++ E  AE + ++             +       +A      +      
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGP----------HELSTSQNDNAHLQCSLQTTMNKL 1300

Query: 538  NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEE 597
            NE E+ C +LQ +  EL +EL + R++     +      +EEV    G +  E  + +++
Sbjct: 1301 NELEKICEILQAEKYELVTELNDSRSEC----ITATRKMAEEV----GKLLNEVKILNDD 1352

Query: 598  CNPLNMSIEAEL----VIEQMKEQHHRDICCL-------RLELEDK-VRHYEKQLDETVV 645
               L+  +  ++      EQ  EQH   +  L        L L DK V+ +  +L E  +
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFL 1412

Query: 646  SCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 705
            S +   + +  +H      +  ++S+L+  +  L+ +  VL            +  K++Q
Sbjct: 1413 SLQSEHKILHDQHCQ----MSSKMSELQTYVDSLKAENLVLSTNLRNF---QGDLVKEMQ 1465

Query: 706  VKLEE---------------------EKTHLQEKLRLQHEMELKARLTQAQASFEREREG 744
            + LEE                     + +  +  L    +M L + L  A ++ +   + 
Sbjct: 1466 LGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDE 1525

Query: 745  LQSSAWTEEKV-RGLTQELEQFHQEQLTSLVE--KHTLEKEELRKE----LLEKHQRELQ 797
            +  S+  EE + R  T        E+L SL E  + +LEK E + E    +  K  +EL+
Sbjct: 1526 VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE 1585

Query: 798  E--GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE-E 854
            +    E+ E +C R+      Q+ S+ ++  ++  S    +E +   E K  ++   E E
Sbjct: 1586 QLLSSERQELDCLRK------QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELE 1639

Query: 855  KSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQ 914
             ++ + +  +L+       +       R ++  +      E  E+T K  ++ +  +  Q
Sbjct: 1640 VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQ 1699

Query: 915  LLQDLE-DLRNVSETQQSLLSDQILELKSSHKR-------ELREREEVLCQAGASEQLAS 966
              QDL  D+  ++ET     + +    +S           + +   E + +   S   A 
Sbjct: 1700 --QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNAL 1757

Query: 967  QRLERLEMEHDQERQEMMSKLLAMENIHKA-TCETADRERAEMSTEISRLQSKI--KEMQ 1023
              ++ L  + D    ++  K  + EN+      E  DR+   +  E+  L SK+  +E+Q
Sbjct: 1758 VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQ 1817

Query: 1024 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQ----QGEQLLEE-------NGDVLLSLQR 1072
              T   + ++   +++GE + E       L+      ++LL+        N D+ +   +
Sbjct: 1818 LMTKIEACIELE-KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876

Query: 1073 AHEQAVKENVK------------MATEISRLQQRLQKLE-PGLVMSSCLDEPATEFFGNT 1119
            +  + + +NV             +  E+SR++     +E   L + + L+   TE     
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-- 1934

Query: 1120 AEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG 1179
                    + N  KQ   V     LS +  +  +  G   T S +   +  + SE   E 
Sbjct: 1935 ------LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALD-QLSEKMKEK 1987

Query: 1180 FSELENSEETRTESWELKN-QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1238
              ELE+ +       ++   ++ +  E L  L +D         +LL D + L++KL+ L
Sbjct: 1988 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS-------ELLKDKTHLQEKLQSL 2040

Query: 1239 ERIPEASPKYKLLYED----VSRENDCLQEELRMMETRYDEA----LENNKELTAEVFRL 1290
            E+  +A    K   E+    +++E + L +E   ++ R  E+    L  +K L A +   
Sbjct: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100

Query: 1291 QDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEA 1350
             +   ++    E    L +  +++++  E      L +  K+++ +       D      
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD------ 2154

Query: 1351 SLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIA 1410
             +ENLE E     LQ+++  +E V          E  K E + L+  TQ+ E  ++ ++ 
Sbjct: 2155 KVENLERE-----LQMSEENQELVILDA------ENSKAEVETLK--TQIEEMARSLKVF 2201

Query: 1411 WLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF---------QHQATIAELELEKTKL 1461
             L   +    E+  +  Q+  +E    L   DK           + QA I   E  KT +
Sbjct: 2202 ELD-LVTLRSEKENLTKQI--QEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAV 2258

Query: 1462 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1521
            + L  +LKE        + V +    +E +KA    L     E  Q    +     +L+ 
Sbjct: 2259 EMLQNQLKEL------NEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
            +       +  L E +  ++L  G +   + E+  +     QE+AA++   EN K ++  
Sbjct: 2313 DEKKQLCVLQQLKESEHHADLLKGRVENLEREL--EIARTNQEHAALE--AENSKGEVET 2368

Query: 1582 LKIKNQ---------QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEE 1632
            LK K +         +LD+      ++N  N+  LQ+  +R++E+  +       + L+E
Sbjct: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNE--LQKEQERISEL--EIINSSFENILQE 2424

Query: 1633 REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRC 1692
            +EQEK  +KE+       SST +  L+ +L E+  +   +  +    K + + +     C
Sbjct: 2425 KEQEKVQMKEK-------SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVEC 2477

Query: 1693 PDLSD----------------FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL 1736
             +L                   Q  ++ ++   E   ++ E   EE++   +++     L
Sbjct: 2478 LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQL 2537

Query: 1737 EHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEK 1796
              +++ ++ E + W+ Q+  L++  V  ++K+Q L+    ++   +  ++S  +  + E 
Sbjct: 2538 VSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597

Query: 1797 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQ--QKRLSWDKLDHLMNEEQQLLWQ 1854
            E  K + MS  +++     K    +   H         Q+ LS +K  + +  E QLL +
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK--NRLAGELQLLLE 2655

Query: 1855 ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1914
            E       ++++K +L     +  +L+ +L   H+  +   G           ++ E  +
Sbjct: 2656 E-------IKSSKDQLKELTLENSELKKSLDCMHKDQVEKEG----------KVREEIAE 2698

Query: 1915 FQKEQSPANRKVSQM---NSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSP 1971
            +Q     A +K   +    + + E+E I    E L  K+  L  Q +E+  L+S+     
Sbjct: 2699 YQLRLHEAEKKHQALLLDTNKQYEVE-IQTYREKLTSKEECLSSQKLEIDLLKSSKEELN 2757

Query: 1972 SPHAWDLQLLQQQACPMVPREQFL-QLQRQLLQAE-------RINQHLQEELENRTSETN 2023
            +      Q+L++     +   +++ QL+++  +A+       +  + L+EE E    E +
Sbjct: 2758 NSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELS 2817

Query: 2024 TPQGNQE--QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVE 2081
              Q  QE  +  TVM+ ++ E+  ++K +K  L+EK  +  E L K          L + 
Sbjct: 2818 QLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYC-------SLLIS 2870

Query: 2082 NAQLLKALEVTE 2093
            + +L KA E+ E
Sbjct: 2871 HEKLEKAKEMLE 2882



 Score =  143 bits (360), Expect = 2e-33
 Identities = 407/2005 (20%), Positives = 764/2005 (38%), Gaps = 317/2005 (15%)

Query: 256  SASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQ 315
            S+++    ++R  S   F  SG +  T S  T  IG R          ++S   +LD   
Sbjct: 229  SSNSQRTPIRRDFSASYF--SGEQEVTPSRSTLQIGKR--DANSSFFDNSSSPHLLDQ-- 282

Query: 316  EEGIENSQEILKALDFSLDGNINLTELTL-ALENELLVTKNSIHQAALASFKAEIRHLLE 374
                      LKA +  L   IN  EL L   E E+    N   +  L   KA++  L+E
Sbjct: 283  ----------LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVE-LIE 331

Query: 375  RV-------DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR-KLDEEY 426
            +        D++VR   +      K   L+  +    +D   + +R+N  + R  L+++ 
Sbjct: 332  KEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTED--LSCQRQNAESARCSLEQKI 389

Query: 427  KERIAALKNELRKER---EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRL 483
            KE+    + EL +++   + + Q+  + +  L QE+++AK   N ++  L        +L
Sbjct: 390  KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449

Query: 484  ENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQ 543
            EN L E  +KL   E      Q                      ++E  L +   E +++
Sbjct: 450  ENNLEEFKQKLCRAEQAFQASQ----------------------IKENELRRSMEEMKKE 487

Query: 544  CRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNM 603
              +L+   ++   E+    A+ + ++  L  S +                 +EE    N 
Sbjct: 488  NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF----------------AEEMKAKNT 531

Query: 604  SIEAELVIEQMKEQHHRDICCLRLE-LEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 662
            S   E ++  ++E+ ++    L LE L+  V   EKQ D +    KK + +++Q ++  +
Sbjct: 532  S--QETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589

Query: 663  HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ 722
             T EK+   L + +   + +   LKE     +C   E +K L  ++E EK +LQ K+   
Sbjct: 590  KT-EKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL-TQMESEKENLQSKIN-H 646

Query: 723  HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 782
             E  LK +  ++    ER R         E     L+ E+   H    +  VE  T +  
Sbjct: 647  LETCLKTQQIKSHEYNERVRT-------LEMDRENLSVEIRNLHNVLDSKSVEVETQKLA 699

Query: 783  ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQ 842
             +  EL +K +   Q+ ++++E  C  +TSQ+  Q         E  E  LQ L      
Sbjct: 700  YM--ELQQKAEFSDQKHQKEIENMC-LKTSQLTGQ--------VEDLEHKLQLLSNEI-- 746

Query: 843  ELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 902
                              +KD   Q+     E L++ LK  K  SLV          T +
Sbjct: 747  -----------------MDKDRCYQDLHAEYESLRDLLK-SKDASLV----------TNE 778

Query: 903  EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQI---LELKSSHKRE--LREREEVLCQ 957
            +H  S++   QQ         N+   Q S+ S++    LE   S K    L+ R + L  
Sbjct: 779  DHQRSLLAFDQQPAMH-HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEF 837

Query: 958  AGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1017
            +  S++  +  L++   E  Q + E+   L+  E +H++         AE S  IS+LQ 
Sbjct: 838  SLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFV-------AETSQRISKLQE 890

Query: 1018 KIKEMQ----QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA 1073
                 Q    +  S L   +   Q++ ++       +  L++   LLE   D L  LQ  
Sbjct: 891  DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE---DSLKELQLL 947

Query: 1074 HEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ--QNR 1131
             E    E  +M++ IS  ++ +++L         ++    +   N  +++E F      R
Sbjct: 948  SETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER 1007

Query: 1132 TKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRT 1191
             K +        LSD    E   L      +    E   ++ +A+ E  S+LE      T
Sbjct: 1008 EKSISE------LSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061

Query: 1192 ESWE-LKNQISQLQEQLMM----LCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASP 1246
               E  KN++ QL+E               A E+ Q+L+ ++  +++ L+    + +   
Sbjct: 1062 SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR--SEMTDNQN 1119

Query: 1247 KYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLS 1306
              K     + +E   L+EE   M+   ++ L+ N++L  +V + + E + +E        
Sbjct: 1120 NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLM-KVMKTKHECQNLES------- 1171

Query: 1307 LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQ 1365
             E   + VK    E N    + Q  +E  + S+          EA L N E++     LQ
Sbjct: 1172 -EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELK-----LQ 1225

Query: 1366 LNQTLEECVPR-VRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPR 1424
             ++  +EC+   ++++   +E    ++      +Q +  +K  EI      I    E   
Sbjct: 1226 ESEKEKECLQHELQTIRGDLETSNLQDM----QSQEISGLKDCEIDAEEKYISGPHELST 1281

Query: 1425 VQN-----QVILEENTTLLGFQDK-----HFQHQATIAELELEKTKLQELTRKLKERVTI 1474
             QN     Q  L+     L   +K       +    + EL   +++    TRK+ E V  
Sbjct: 1282 SQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGK 1341

Query: 1475 LVKQKDVLS------HGEKEEELKA--------MMHDLQITCSEMQQKVELLRYESEKLQ 1520
            L+ +  +L+      HGE  E++            H + +   +     E L    +++Q
Sbjct: 1342 LLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQ 1401

Query: 1521 QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQIS 1580
               + L+ +  +L  E  I + +   ++    E+    +++K EN  +   + N +  + 
Sbjct: 1402 MHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL- 1460

Query: 1581 ELKIKNQQLDLENTELSQKNSQ-------------------------------NQEKLQE 1609
               +K  QL LE   +   +S                                N E    
Sbjct: 1461 ---VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVS 1517

Query: 1610 LNQ-RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQ 1668
             NQ  + E+ C   +E   +  E        ++E    C+V   +L    E   S+  ++
Sbjct: 1518 ANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK 1577

Query: 1669 THIVQQENHLLKDELEKMKQLHR--CPDLSDFQQKISSV-LSYNEKLLKEK---EALSEE 1722
               +Q+   LL  E +++  L +    +   +QQK++SV L    KL  EK   E LS E
Sbjct: 1578 NKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLE 1637

Query: 1723 LNSCVDKLAKSSLLEHRIATMKQEQK----------SWEHQSASLKSQLVASQEKVQNLE 1772
            L     +L    L    +  +  E            S EH S + +        ++ + +
Sbjct: 1638 LEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD-K 1696

Query: 1773 DTVQNVNLQMSRMKSDLRVTQ------------------QEKEALKQEVMSLHKQLQNAG 1814
            D  Q++NL + ++     V                    ++K     E +S   +L  +G
Sbjct: 1697 DAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECIS---ELSFSG 1753

Query: 1815 GKSWAP-EIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1873
              +  P +   +   +HN Q R+         NE  +LL    +R    V++   E+   
Sbjct: 1754 PNALVPMDFLGNQEDIHNLQLRVK-----ETSNENLRLLHVIEDR-DRKVESLLNEMKEL 1807

Query: 1874 REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLE 1933
              K+   E  L+ K +  +     +   ++E   L  + + F  +     ++V     L 
Sbjct: 1808 DSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLN 1867

Query: 1934 QELETIHLE--------------NEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQ 1979
             +LE +H +              N+  K++ + ++ +L  ++  +++          DL+
Sbjct: 1868 SDLE-MHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLE 1926

Query: 1980 LLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQE--------- 2030
            ++Q +          L L++     +++   L+EEL   TSE N  +G  +         
Sbjct: 1927 VVQTEK---------LCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 1977

Query: 2031 -QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKAL 2089
             QL   M+E+  E+E         +Q    ++KE+        + V +L  +   L + L
Sbjct: 1978 DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKL 2037

Query: 2090 EVTEQRQKTAEKKNYLLEEKIASLS 2114
            +  E+  +        LE +IA L+
Sbjct: 2038 QSLEKDSQALSLTKCELENQIAQLN 2062



 Score =  140 bits (353), Expect = 1e-32
 Identities = 304/1457 (20%), Positives = 622/1457 (42%), Gaps = 210/1457 (14%)

Query: 762  LEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRE---------LQEGREKMETECNRRTS 812
            LE++ +   T  ++K    + +L K   EK QR+         LQ+ ++K+E E    T+
Sbjct: 5    LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64

Query: 813  QIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEA 872
                  + + Q++ E CES L+  + +   EL+  + Q   ++ Q    K ++       
Sbjct: 65   -----LKRENQRLMEICES-LEKTKQKISHELQVKESQVNFQEGQLNSGKKQI------- 111

Query: 873  QELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSL 932
             E L++ LKR K+           LE++            QQ  Q  +   N   T Q +
Sbjct: 112  -EKLEQELKRCKSE----------LERS------------QQAAQSADVSLNPCNTPQKI 148

Query: 933  LSDQIL-----------ELKSSHKRELREREEVLCQAGASE-QLASQRLERLEMEH-DQE 979
             +  +            +LK  + +E+ ER+ +  +  A + + ASQ L +  M H D  
Sbjct: 149  FTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIA 208

Query: 980  RQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVI 1039
            R +  S + + +     +  +++ +R  +  + S   S     Q+ T   S LQ G +  
Sbjct: 209  RHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS--ASYFSGEQEVTPSRSTLQIGKRDA 266

Query: 1040 GEEEVEGDGALSLLQ----QGEQLLEENGDVLLSLQRAHEQAVKENVKMATEIS-RLQQ- 1093
                 +   +  LL     Q ++L  +  ++ L LQ  HE+ +K  V    E+  +L++ 
Sbjct: 267  NSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQ-GHEKEMKGQVNKFQELQLQLEKA 325

Query: 1094 RLQKLEPGLVMSSCLDE-PATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEV 1152
            +++ +E   V++ C DE   T    + A      L+Q   K  E ++ +           
Sbjct: 326  KVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ----------- 374

Query: 1153 RDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLM---- 1208
            R    +   S++ Q++K +E E   E   +  + +    E  ++K +++Q  +Q      
Sbjct: 375  RQNAESARCSLE-QKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433

Query: 1209 MLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASP----KYKLLYEDVSRENDCLQ- 1263
            +L A+ D+ +  KQ L  ++   K+KL   E+  +AS     + +   E++ +EN+ L+ 
Sbjct: 434  VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKS 493

Query: 1264 -EELRMMETRYDEA-LENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1321
              E +  E  + EA L+N K+   +     +E+K      ET L   +   E KI  +E 
Sbjct: 494  HSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML---RDLQE-KINQQEN 549

Query: 1322 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1381
            ++ + +L+  +  L++   QR DC       ++L  + + +I QLN  L +     +++ 
Sbjct: 550  SLTLEKLKLAVADLEK---QR-DCS------QDLLKKREHHIEQLNDKLSKTEKESKALL 599

Query: 1382 HVIEECKQENQYLE-----------GNTQLLEKVKAH------EIAWLHGTIQTHQERPR 1424
              +E  K+E + L+            N +LL ++++       +I  L   ++T Q +  
Sbjct: 600  SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSH 659

Query: 1425 VQNQVI--LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDV- 1481
              N+ +  LE +   L  + ++  +      +E+E  KL  +  + K   +    QK++ 
Sbjct: 660  EYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIE 719

Query: 1482 ---LSHGEKEEELKAMMHDLQITCSEMQQK---VELLRYESEKLQ-----QENSILRNE- 1529
               L   +   +++ + H LQ+  +E+  K    + L  E E L+     ++ S++ NE 
Sbjct: 720  NMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNED 779

Query: 1530 ----ITTLNEE----DSISNL--KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1579
                +   +++     S +N+  + G++   + E   + +   + +A +Q  V++L+  +
Sbjct: 780  HQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSL 839

Query: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN 1639
               K  N  L  +  EL Q   + +E L +  Q     + +  +    S L+E      N
Sbjct: 840  ESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR--ISKLQEDTSAHQN 897

Query: 1640 LKEE----LERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDL 1695
            +  E    LE  + +   L   +E E +E++     +++ NHLL+D L++++ L     L
Sbjct: 898  VVAETLSALENKEKELQLLNDKVETEQAEIQ----ELKKSNHLLEDSLKELQLLSE--TL 951

Query: 1696 SDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSA 1755
            S  ++++SS++S N+   +E E L++E          +  L+   A++ QE+ +   +S 
Sbjct: 952  SLEKKEMSSIISLNK---REIEELTQE----------NGTLKEINASLNQEKMNLIQKSE 998

Query: 1756 SLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGG 1815
            S  + +   ++ +  L D          + K +  +  Q  E        L ++ + A  
Sbjct: 999  SFANYIDEREKSISELSD----------QYKQEKLILLQRCEETGNAYEDLSQKYKAAQE 1048

Query: 1816 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1875
            K+   E   +      + ++   ++L     +E Q    +    +   QN   EL    E
Sbjct: 1049 KNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLEL----E 1104

Query: 1876 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQ-MNSLEQ 1934
             V+Q   + +  +Q   N        +QE ++LK E ++ QKE +   ++  Q M  ++ 
Sbjct: 1105 TVQQALRSEMTDNQN--NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKT 1162

Query: 1935 ELETIHLENEGLKK--KQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPRE 1992
            + E  +LE+E ++   K+ + +      +          S  +++ QL+Q +A   + R 
Sbjct: 1163 KHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEA---MLRN 1219

Query: 1993 QFLQLQRQLLQAERINQHLQEELENRTS--ETNTPQGNQEQLVTVMEERMIEVEQKLKLV 2050
            + L+LQ    ++E+  + LQ EL+      ET+  Q  Q Q ++ +++  I+ E+K    
Sbjct: 1220 KELKLQ----ESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISG 1275

Query: 2051 KRLLQEKVN-------QLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKN 2103
               L    N        L+  + K  + + + + L  E  +L+  L  +     TA +K 
Sbjct: 1276 PHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRK- 1334

Query: 2104 YLLEEKIASLSNIVRNL 2120
              + E++  L N V+ L
Sbjct: 1335 --MAEEVGKLLNEVKIL 1349



 Score =  139 bits (350), Expect = 3e-32
 Identities = 248/1139 (21%), Positives = 484/1139 (42%), Gaps = 196/1139 (17%)

Query: 278  RRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNI 337
            +R  TS  + S +         + +G  +V ++ D+W+E  ++   E+ +    S   +I
Sbjct: 1858 QRVETSEGLNSDLEMHADKSSREDIGD-NVAKVNDSWKERFLDVENELSRIR--SEKASI 1914

Query: 338  NLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLK 397
                L L  + E++ T+    +    + +  I  L E +  V  E+ +LR +LD   K  
Sbjct: 1915 EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT 1974

Query: 398  SLM---ASEVDDHHAAIERRNE---YNLRKLDEEYKERIAALK------NELRKEREQI- 444
            + +   + ++ +    +E       + ++  + E KE+   L+      +EL K++  + 
Sbjct: 1975 TALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQ 2034

Query: 445  --LQQAGKQ-------RLELEQEIEKAKTEENYI-------RDRLALS----LKENSRLE 484
              LQ   K        + ELE +I +   E+  +       + RL+ S    L  +  LE
Sbjct: 2035 EKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE 2094

Query: 485  NELLENAE---KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 541
              L+E  E   +L+  +   ++L+R +E +      D          ++  + +   E E
Sbjct: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK--------KQLHIAEKLKERE 2146

Query: 542  RQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
            R+   L+D+V+ L+ EL+       ++ L  +NS +E     +   E    L   E + +
Sbjct: 2147 RENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206

Query: 602  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENE 661
             +  E E + +Q++E+  +       EL+  +  ++  L+E     ++A+  +K+  +  
Sbjct: 2207 TLRSEKENLTKQIQEKQGQ-----LSELDKLLSSFKSLLEEK----EQAEIQIKEESKTA 2257

Query: 662  THTLEKQISDLKNEIAELQGQAAVLK----------EAHHEATCRHE--------EEKKQ 703
               L+ Q+ +L   +A L G   ++K          E  H+     E        +EKKQ
Sbjct: 2258 VEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ 2317

Query: 704  LQV--KLEEEKTH---LQEKL-RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRG 757
            L V  +L+E + H   L+ ++  L+ E+E+ AR  Q  A+ E E    +     + K+ G
Sbjct: 2318 LCVLQQLKESEHHADLLKGRVENLERELEI-ARTNQEHAALEAENSKGEVET-LKAKIEG 2375

Query: 758  LTQELEQFHQEQLTSLVEK----HTLEKEELR---KELLEKHQRELQEGREKMETECNRR 810
            +TQ L     + +T   EK    + L+KE+ R    E++      + + +E+ + +   +
Sbjct: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEK 2435

Query: 811  TSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ-WEFEKDELTQEC 869
            +S      Q+  +++ ER  +AL +      QE    +EQ    + +  E EK +L Q  
Sbjct: 2436 SSTAMEMLQTQLKELNERV-AALHN-----DQEACKAKEQNLSSQVECLELEKAQLLQGL 2489

Query: 870  AEAQELLKETLKREKTTSLVLTQE--REMLEKTYKE--HLNSMVVERQQLLQDLEDLRNV 925
             EA+      + +     L+   E  ++ LEK  +E   L + + +++QL+  L  +   
Sbjct: 2490 DEAKN--NYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV--- 2544

Query: 926  SETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEM-- 983
             E +  L  +Q LEL++    EL ++ +VL    AS Q     LE L+  +     E+  
Sbjct: 2545 -EGEHQLWKEQNLELRNL-TVELEQKIQVLQSKNASLQ---DTLEVLQSSYKNLENELEL 2599

Query: 984  --MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSG--CQVI 1039
              M K+  +E ++K T +  +            LQ ++ EM Q T+ L    SG   ++ 
Sbjct: 2600 TKMDKMSFVEKVNKMTAKETE------------LQREMHEMAQKTAELQEELSGEKNRLA 2647

Query: 1040 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE 1099
            GE ++  +   S   Q ++L  EN ++  SL   H+  V++  K+  EI+  Q RL + E
Sbjct: 2648 GELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAE 2707

Query: 1100 PGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG 1159
                                 +     L  N+  +VE  T R  L+  E+          
Sbjct: 2708 --------------------KKHQALLLDTNKQYEVEIQTYREKLTSKEE---------- 2737

Query: 1160 TSSVQRQEVKI-----EESEASVEGFSE-LENSEETRTESWELKNQI----SQLQEQLMM 1209
              S Q+ E+ +     EE   S++  ++ LE  ++T+ ++ +  NQ+     + Q ++ +
Sbjct: 2738 CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKL 2797

Query: 1210 LCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1269
            L   C +  E+K+       +L+K+L  L+   E                   Q+   +M
Sbjct: 2798 LIKSCKQLEEEKE-------ILQKELSQLQAAQEK------------------QKTGTVM 2832

Query: 1270 ETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1328
            +T+ DE     KEL      L+++ K+ +E  + + SL  S+++++   E L   V  L
Sbjct: 2833 DTKVDELTTEIKELKE---TLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888



 Score =  136 bits (343), Expect = 2e-31
 Identities = 358/1799 (19%), Positives = 690/1799 (38%), Gaps = 307/1799 (17%)

Query: 437  LRKEREQILQQAGKQRLELEQEIEKAKTEEN---YIRDRLALSL-KENSRLENELLENAE 492
            L + +E +  +A ++  ELE +++K K E+    +  D L  +L K+  ++ENE  E   
Sbjct: 5    LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT- 63

Query: 493  KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 552
                  NL  + QR +E                     E L + + +   + +V + QV+
Sbjct: 64   ------NLKRENQRLMEIC-------------------ESLEKTKQKISHELQVKESQVN 98

Query: 553  ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612
              + +L   + Q   L   LK   SE   +       +  L     NP N   +      
Sbjct: 99   FQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSL-----NPCNTPQKI----- 148

Query: 613  QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDL 672
                                   +   L  +        E++K+++  E    ++  +++
Sbjct: 149  -----------------------FTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185

Query: 673  KNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLT 732
            K   A+   Q       +H    RH+        + E+  +HL       +      R  
Sbjct: 186  KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLS-----SNSQRTPIRRD 240

Query: 733  QAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKH 792
             + + F  E+E   S +  +   R        F       L+++   + +ELR ++ E  
Sbjct: 241  FSASYFSGEQEVTPSRSTLQIGKRDANSSF--FDNSSSPHLLDQLKAQNQELRNKINELE 298

Query: 793  QRELQEGREKMETECNRRTSQIEAQFQS------DCQKVTERCESALQSLEGRY------ 840
             R LQ   ++M+ + N +  +++ Q +       + +KV  +C   L     +Y      
Sbjct: 299  LR-LQGHEKEMKGQVN-KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTK 356

Query: 841  ----RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREM 896
                 Q+LK L E    ++   E  +  L Q+  E ++  +E L R++ +   L QE   
Sbjct: 357  YTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE--- 413

Query: 897  LEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLC 956
                        +  + +L Q+L+  +N+    Q+ L D++  +K   +  L E ++ LC
Sbjct: 414  -----------CIQMKARLTQELQQAKNMHNVLQAEL-DKLTSVKQQLENNLEEFKQKLC 461

Query: 957  ---QAGASEQLASQRLER-----------LEMEHDQERQEMMSKLLAMENIHKAT----- 997
               QA  + Q+    L R           L+   +Q+ +E+      ++NI +       
Sbjct: 462  RAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN 521

Query: 998  -CETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQG 1056
              E    +     T +  LQ KI + + + +    L+     + + E + D +  LL++ 
Sbjct: 522  FAEEMKAKNTSQETMLRDLQEKINQQENSLT----LEKLKLAVADLEKQRDCSQDLLKKR 577

Query: 1057 EQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFF 1116
            E  +E+  D L        +  KE+  + + +   ++  ++L+    + SC      +  
Sbjct: 578  EHHIEQLNDKL-------SKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630

Query: 1117 GNTAEQTEPFLQQ-------NRTKQVEGVTRRHVLSDLEDD------EVRDLGSTGTS-- 1161
                 + E    +        +T+Q++       +  LE D      E+R+L +   S  
Sbjct: 631  TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690

Query: 1162 -SVQRQEVKIEESEASVEGFSELENSEETRT---ESWELKNQISQLQEQLMMLCADCDRA 1217
              V+ Q++   E +   E FS+ ++ +E      ++ +L  Q+  L+ +L +L  +    
Sbjct: 691  VEVETQKLAYMELQQKAE-FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDK 749

Query: 1218 SEKKQDLLFDVSVLKKKLKMLER-------------IPEASPKYKLLYEDVSRENDCLQE 1264
                QDL  +   L+  LK  +                +  P     + ++  E   +  
Sbjct: 750  DRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPS 809

Query: 1265 ELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT-------ETFLSLEKSYDEVKIE 1317
            E        D++ +N+  L   V  L+  L+  +++        E  + ++   +E  ++
Sbjct: 810  ERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMK 869

Query: 1318 NEELN-VLVLRLQGKIEKLQESVVQRCDCCLWEAS-LENLEIEPDGNILQL----NQTLE 1371
             E+++   V     +I KLQE      +      S LEN E E     LQL     +T +
Sbjct: 870  AEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE-----LQLLNDKVETEQ 924

Query: 1372 ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVIL 1431
              +  ++  +H++E+  +E Q L   T  LEK +   I  L+   +   E    +N  + 
Sbjct: 925  AEIQELKKSNHLLEDSLKELQLL-SETLSLEKKEMSSIISLN---KREIEELTQENGTLK 980

Query: 1432 EENTTLLGFQDKHFQHQATIAELELEKTK-LQELTRKLKERVTILVKQKDVLSHG----- 1485
            E N +L   +    Q   + A    E+ K + EL+ + K+   IL+++ +   +      
Sbjct: 981  EINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLS 1040

Query: 1486 -------EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDS 1538
                   EK  +L+ ++++    C   + ++E L+   E   +E+     ++    E + 
Sbjct: 1041 QKYKAAQEKNSKLECLLNECTSLCENRKNELEQLK---EAFAKEHQEFLTKLAFAEERNQ 1097

Query: 1539 ISNLKLGTLNGS-QEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1597
               L+L T+  + + EM       K E          LK++I  LK +  ++  E  +L 
Sbjct: 1098 NLMLELETVQQALRSEMTDNQNNSKSE-------AGGLKQEIMTLKEEQNKMQKEVNDLL 1150

Query: 1598 QKNSQNQEKLQELNQRLTEMLCQK-EKEPGNSALEEREQEK--FNLKEELERCKVQSSTL 1654
            Q+N Q  + ++      T+  CQ  E EP  ++++ERE E+   N K +++  +V+  +L
Sbjct: 1151 QENEQLMKVMK------TKHECQNLESEPIRNSVKERESERNQCNFKPQMD-LEVKEISL 1203

Query: 1655 VS------SLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQ-QKISSV-- 1705
             S       LEA L   +++    ++E   L+ EL+ ++      +L D Q Q+IS +  
Sbjct: 1204 DSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKD 1263

Query: 1706 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1763
              +   EK +     LS   N   D       L+  +  + + +K  E   A        
Sbjct: 1264 CEIDAEEKYISGPHELSTSQN---DNAHLQCSLQTTMNKLNELEKICEILQAE------- 1313

Query: 1764 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQN--AGGKSWAPE 1821
              E V  L D+         +M  ++     E + L  +   LH +L     GG     E
Sbjct: 1314 KYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGG-----E 1368

Query: 1822 IATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLE 1881
                P    N+Q  +S   LD   N  + L   + E     VQ   AEL   +EK   L+
Sbjct: 1369 FGEQP----NEQHPVSLAPLDE-SNSYEHLTLSDKE-----VQMHFAEL---QEKFLSLQ 1415

Query: 1882 SNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHL 1941
            S     H +H   S  M+  +    SLK E                   +L       + 
Sbjct: 1416 SEHKILHDQHCQMSSKMSELQTYVDSLKAE-------------------NLVLSTNLRNF 1456

Query: 1942 ENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQF--LQLQR 1999
            + + +K+ Q+ L+E L  +  L S+  P  S     L  L   +      EQ   + L  
Sbjct: 1457 QGDLVKEMQLGLEEGL--VPSLSSSCVPDSS----SLSSLGDSSFYRALLEQTGDMSLLS 1510

Query: 2000 QLLQAERINQ---------HLQEELENRTSETNTPQGNQEQLVTVME---ERMIEVEQKL 2047
             L  A   NQ          LQEE   R    + P    E+L ++ E   + + ++E+K+
Sbjct: 1511 NLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM 1570

Query: 2048 KLVKRLLQEKVNQLKEQL-CKNTKADAMVKDLYVEN---AQLLKALEVTEQRQKTAEKK 2102
            +    +  +++ +L++ L  +  + D + K    EN    Q L ++ +  + +  AEKK
Sbjct: 1571 ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKK 1629



 Score =  127 bits (320), Expect = 9e-29
 Identities = 261/1243 (20%), Positives = 508/1243 (40%), Gaps = 193/1243 (15%)

Query: 333  LDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDK 392
            LD  ++L E+ L  + E  +    I    +   K E   L E+++    + ++L   ++ 
Sbjct: 1807 LDSKLHLQEVQLMTKIEACIELEKI----VGELKKENSDLSEKLEYFSCDHQELLQRVET 1862

Query: 393  AEKLKSLMASEVDDHHAAIERRNEY--NLRKLDEEYKERIAALKNEL---RKEREQILQQ 447
            +E L S +     + HA    R +   N+ K+++ +KER   ++NEL   R E+  I  +
Sbjct: 1863 SEGLNSDL-----EMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 1917

Query: 448  AGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRN 507
            A    L LE ++E  +TE      +L L  K+N   +  ++   E+L+   +  N+L+  
Sbjct: 1918 A----LYLEADLEVVQTE------KLCLE-KDNENKQKVIVCLEEELSVVTSERNQLRGE 1966

Query: 508  LENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRV 567
            L+  +++K   LD  S +   + + L   ++E     +V + +V E    L+   +    
Sbjct: 1967 LDT-MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD--- 2022

Query: 568  LRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRL 627
                                                      V E +K++ H        
Sbjct: 2023 ------------------------------------------VSELLKDKTH-------- 2032

Query: 628  ELEDKVRHYEKQLDETVVSCKKAQ-ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVL 686
             L++K++  EK  D   +S  K + EN   +   E   L K+   L+  ++E   +   +
Sbjct: 2033 -LQEKLQSLEK--DSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNV 2089

Query: 687  KEAHHEATCRHEEEKKQLQVKLEEEKTHLQ----EKLRLQHEMELKARLTQAQASFERER 742
             +A   A    E+ +  L++   +E+ H      EKLR++ E + K +L  A+   ERER
Sbjct: 2090 SKALEAALV--EKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERER 2147

Query: 743  EGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE-ELRKELLEKHQRELQEGRE 801
            E        ++KV  L +EL+   + Q   +++    + E E  K  +E+  R L+    
Sbjct: 2148 ENDS----LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFEL 2203

Query: 802  KMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFE 861
             + T  + + + +  Q Q    +++E     L  L   ++  L        EEK Q E +
Sbjct: 2204 DLVTLRSEKEN-LTKQIQEKQGQLSE-----LDKLLSSFKSLL--------EEKEQAEIQ 2249

Query: 862  KDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLED 921
               + +E   A E+L+  LK        L  ++E+++ T ++ L+  + E  QL   +E 
Sbjct: 2250 ---IKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKAT-EQSLDPPIEEEHQLRNSIEK 2305

Query: 922  LRNVSETQQSLLSDQILELKSS--HKRELREREEVLCQAGASEQLASQRLERLEMEHDQE 979
            LR   E  +      + +LK S  H   L+ R E L +     ++A    E   +E +  
Sbjct: 2306 LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLER---ELEIARTNQEHAALEAENS 2362

Query: 980  RQEMMSKLLAMENIHKAT------CETADRERAEMSTEISRLQSKIKEMQQATSPL-SML 1032
            + E+ +    +E + ++         T   E+  ++ E+ + Q +I E++   S   ++L
Sbjct: 2363 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL 2422

Query: 1033 QSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQ 1092
            Q   Q   + + +   A+ +LQ     L+E  + + +L    E    +   +++++  L+
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQ---LKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479

Query: 1093 QRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEV 1152
                +L  GL      DE    +           LQ +    ++ V       + +D+E+
Sbjct: 2480 LEKAQLLQGL------DEAKNNYI---------VLQSSVNGLIQEVEDGKQKLEKKDEEI 2524

Query: 1153 RDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEET-RTESWELKNQISQLQEQLMMLC 1211
                        R + +I++ E  V   S++E   +  + ++ EL+N   +L++++ +L 
Sbjct: 2525 -----------SRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVL- 2572

Query: 1212 ADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEEL-RMME 1270
                    K   L   + VL+   K LE   E +   K+ + +   +    + EL R M 
Sbjct: 2573 ------QSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMH 2626

Query: 1271 TRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQG 1330
                +  E  +EL+ E  RL  EL+ +    E   S +    E+ +EN EL    L    
Sbjct: 2627 EMAQKTAELQEELSGEKNRLAGELQLL---LEEIKSSKDQLKELTLENSELKKS-LDCMH 2682

Query: 1331 KIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQ--------------TLEECVPR 1376
            K +  +E  V+  +   ++  L   E +    +L  N+              + EEC+  
Sbjct: 2683 KDQVEKEGKVRE-EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSS 2741

Query: 1377 VRSVHHVIEECKQE-NQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENT 1435
             +    +++  K+E N  L+  TQ+LE++K  ++  L    Q  +E  R Q ++      
Sbjct: 2742 QKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM------ 2795

Query: 1436 TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMM 1495
             LL    K  + +  I + EL  ++LQ    K K    +  K  ++ +   + +ELK  +
Sbjct: 2796 KLLIKSCKQLEEEKEILQKEL--SQLQAAQEKQKTGTVMDTKVDELTT---EIKELKETL 2850

Query: 1496 HDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDS 1538
             +      E   K   L    EKL++   +L  ++  L  + S
Sbjct: 2851 EEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQS 2893



 Score =  127 bits (319), Expect = 1e-28
 Identities = 379/1818 (20%), Positives = 734/1818 (40%), Gaps = 256/1818 (14%)

Query: 311  LDTWQEEGIENSQEILKALDFSLDG--------NINLTELTLALENELLVTKNSIHQAAL 362
            L+ W+E     + + ++ L+  LD            L  L  AL+ +    +N   +   
Sbjct: 5    LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT- 63

Query: 363  ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKL 422
             + K E + L+E  + + + K+K+  +L   E   +    +++     IE+  +   R  
Sbjct: 64   -NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122

Query: 423  DEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 482
             E  + + AA   ++        Q+     L   Q    +K E+  ++++    ++E  R
Sbjct: 123  SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYED--LKEKYNKEVEERKR 180

Query: 483  LENELLE-NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 541
            LE E+    A+K ++         R++    A        SS+ F  Q+E+     +   
Sbjct: 181  LEAEVKALQAKKASQTLPQATMNHRDIARHQA--------SSSVFSWQQEKTPSHLSSNS 232

Query: 542  RQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
            ++  + +D      S  +E       L++  +++ S   + NS        L ++     
Sbjct: 233  QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFD-NSSSPHLLDQLKAQNQELR 291

Query: 602  NMSIEAELVIE----QMKEQHHRDICCLRLELED-KVRHYEKQLDETVVSCKKAQENMKQ 656
            N   E EL ++    +MK Q ++    L+L+LE  KV   EK  ++ +  C+        
Sbjct: 292  NKINELELRLQGHEKEMKGQVNK-FQELQLQLEKAKVELIEK--EKVLNKCRDELVRTTA 348

Query: 657  RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
            +++  +     + + L+ ++ +L    +  ++    A C  E++ K+ + + +EE +  Q
Sbjct: 349  QYDQAS----TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404

Query: 717  EKLRL--QHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 774
               +   Q  +++KARLTQ     +     LQ+     +K+  + Q+LE   +E      
Sbjct: 405  RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL---DKLTSVKQQLENNLEE------ 455

Query: 775  EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERC--ESA 832
             K  L + E   +  +  + EL+   E+M+ E N   S  E       QK  E C  E+ 
Sbjct: 456  FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE-------QKAREVCHLEAE 508

Query: 833  LQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQ 892
            L++++    Q     +E + +  SQ    +D   QE    QE    +L  EK    V   
Sbjct: 509  LKNIKQCLNQSQNFAEEMKAKNTSQETMLRD--LQEKINQQE---NSLTLEKLKLAVADL 563

Query: 893  EREMLEKTYKEHLNSMVVERQQLLQDLED-LRNVSETQQSLLSDQILELKSSHKRELRER 951
            E++      ++    ++ +R+  ++ L D L    +  ++LLS   LELK     EL+E 
Sbjct: 564  EKQ------RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS--ALELKKKEYEELKE- 614

Query: 952  EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA----------TCETA 1001
            E+ L     SE       E+L  + + E++ + SK+  +E   K              T 
Sbjct: 615  EKTLFSCWKSEN------EKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTL 668

Query: 1002 DRERAEMSTEISRLQSKI--KEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
            + +R  +S EI  L + +  K ++  T  L+ ++                   LQQ  + 
Sbjct: 669  EMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME-------------------LQQKAEF 709

Query: 1060 LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNT 1119
             ++           H+   KE   M  + S+L  +++ LE  L + S         + + 
Sbjct: 710  SDQK----------HQ---KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756

Query: 1120 AEQTEPFLQQNRTKQVEGVTRR-HVLSDLEDDE--------VRDLGSTGTSSVQRQEVKI 1170
              + E      ++K    VT   H  S L  D+           +G  G+   +R E ++
Sbjct: 757  HAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRL 816

Query: 1171 EESEASVEGFSELENSEETRTESWELKNQI-SQLQEQLMMLCADCDRASEKKQDLLFDVS 1229
             E++ S +  + L+N  ++   S E + Q+ S LQ+Q       C+   + K ++  + +
Sbjct: 817  -EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ-------CEELVQIKGEI--EEN 866

Query: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289
            ++K +      + E S +   L ED S   + + E L  +E +  E    N ++  E   
Sbjct: 867  LMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE 926

Query: 1290 LQDELKKMEEVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIEKL--QESVVQRCDCC 1346
            +Q ELKK   + E  L  L+   + + +E +E++ ++   + +IE+L  +   ++  +  
Sbjct: 927  IQ-ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINAS 985

Query: 1347 LWEASLENLEIEPDGNILQLNQTLEECV-PRVRSVHHVIEECKQENQYLEGNTQLLEKVK 1405
            L +  +         N++Q +++    +  R +S+  + ++ KQE   L    +  E   
Sbjct: 986  LNQEKM---------NLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCE--ETGN 1034

Query: 1406 AHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELT 1465
            A+E   L    +  QE+   + + +L E T+L                 E  K +L++L 
Sbjct: 1035 AYED--LSQKYKAAQEK-NSKLECLLNECTSL----------------CENRKNELEQLK 1075

Query: 1466 RKL-KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESE-KLQQEN 1523
                KE    L K    L+  E+  +      +L +    +QQ +     +++   + E 
Sbjct: 1076 EAFAKEHQEFLTK----LAFAEERNQ------NLMLELETVQQALRSEMTDNQNNSKSEA 1125

Query: 1524 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQ----KTETVKQENAAVQKMVENLKKQI 1579
              L+ EI TL EE +    ++  L    E++ +    K E    E+  ++  V+  + + 
Sbjct: 1126 GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER 1185

Query: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN 1639
            ++   K  Q+DLE  E+S  +S N + +Q     L  ML  KE +     L+E E+EK  
Sbjct: 1186 NQCNFK-PQMDLEVKEIS-LDSYNAQLVQ-----LEAMLRNKELK-----LQESEKEKEC 1233

Query: 1640 LKEELE--RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLL-KDELEKMK--QLHRCPD 1694
            L+ EL+  R  +++S L      E+S +K    I  +E ++    EL   +    H    
Sbjct: 1234 LQHELQTIRGDLETSNLQDMQSQEISGLK-DCEIDAEEKYISGPHELSTSQNDNAHLQCS 1292

Query: 1695 LSDFQQKISSVLSYNEKLLKEKEALSEELN-SCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1753
            L     K++ +    E L  EK  L  ELN S  + +  +  +   +  +  E K     
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDD 1352

Query: 1754 SASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1813
            S  L  +LV      +  E   +   + ++ +           E+   E ++L  +    
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL----------DESNSYEHLTLSDK---- 1398

Query: 1814 GGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1873
                   E+  H + L  Q+K LS      +++++   +  +   LQT V + KAE    
Sbjct: 1399 -------EVQMHFAEL--QEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL 1449

Query: 1874 REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLE 1933
               +R  + +L+ + Q  L         E    SL   C       S           LE
Sbjct: 1450 STNLRNFQGDLVKEMQLGLE--------EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLE 1501

Query: 1934 QELETIHLEN-EG-LKKKQVKLDE---QLMEMQHLRSTATPS-PSPHAWDLQLLQQQACP 1987
            Q  +   L N EG +   Q  +DE     ++ ++L    TPS P+    +L+ L +    
Sbjct: 1502 QTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCE---- 1557

Query: 1988 MVPREQFLQLQRQL-LQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQK 2046
             V R+   +L+ ++  Q    N+ +QE  +  +SE       ++Q ++  E    + +QK
Sbjct: 1558 -VYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENE----QWQQK 1612

Query: 2047 LKLVKRLLQEKVNQLKEQ 2064
            L  V   ++ K+   K+Q
Sbjct: 1613 LTSVTLEMESKLAAEKKQ 1630


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  169 bits (428), Expect = 3e-41
 Identities = 296/1353 (21%), Positives = 565/1353 (41%), Gaps = 198/1353 (14%)

Query: 699  EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGL 758
            +E + LQ  L+EEK + +E   L+ E+E    L Q +A    + +GL + +  E  ++ L
Sbjct: 90   QEVQDLQASLKEEKWYSEE---LKKELEKYQGLQQQEA----KPDGLVTDSSAE--LQSL 140

Query: 759  TQELEQ-----FHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
             Q+LE+     F+ +Q+  L E+   +      ++  K+  E +  RE  E +  R T +
Sbjct: 141  EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE-RSLREAAEQKVTRLTEE 199

Query: 814  IEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQ 873
            +  +        TE  +          ++EL  +Q        + E E ++L  EC + Q
Sbjct: 200  LNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQ 259

Query: 874  ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLL 933
                    +  ++   ++Q R  L K  +E +   V E Q+L   + +L   ++T    L
Sbjct: 260  S-------QYASSEATISQLRSELAKGPQE-VAVYVQELQKLKSSVNELTQKNQT----L 307

Query: 934  SDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME-N 992
            ++ +L+ +  + +   +  E        E ++ + ++    + D + Q++ S+L A E +
Sbjct: 308  TENLLKKEQDYTKLEEKHNE--------ESVSKKNIQATLHQKDLDCQQLQSRLSASETS 359

Query: 993  IHKATCETADR---------ERAEMSTEISRLQSKIKEMQQAT-----------SPLSML 1032
            +H+   E +++         E +E+ T+   L+++ K++QQ             S ++ L
Sbjct: 360  LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL 419

Query: 1033 QSGCQVIGEEEVEGDGALSLLQQ--GEQLLEEN---GDVLLSLQRAHEQAVKENVKMATE 1087
             S       +  E  G L   +Q   E+L+++     D+ L L R  EQ +KE V  +TE
Sbjct: 420  HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ-LKEKVTNSTE 478

Query: 1088 ISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQ-----NRTKQVEGVTRRH 1142
               LQ +L K +        L +  T          E  L+Q      + + +E + ++ 
Sbjct: 479  ---LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535

Query: 1143 ------VLSDLEDDEVRDLGSTGTSSV--QRQEVKIEESEASVEGFSELENSEETRTESW 1194
                  +  + ED   +     G ++V  Q QE      E   +   +L+N  E+  ++ 
Sbjct: 536  KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595

Query: 1195 ELKNQISQLQEQLMMLCADCDRASEKK---QDLLFDVSVLKKKLKMLERIPEASPKYKLL 1251
            E  N   Q+QEQ   L A  DR    +    +L   ++  K+K+  L+   +A  +  L 
Sbjct: 596  E--NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653

Query: 1252 YE--------DVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME----E 1299
             E        D+    D  Q  L+  +   ++      ++TA++   Q+   ++E    E
Sbjct: 654  AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713

Query: 1300 VTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP 1359
              E +LSLE+  +E++ + ++L    L ++   E+  + + Q+            L  + 
Sbjct: 714  YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ----------RQLNTDL 763

Query: 1360 DGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH 1419
            +    +L++ LE     V S      + +++++ LE   Q L K +  E   L    +T 
Sbjct: 764  ELRATELSKQLEMEKEIVSSTRL---DLQKKSEALESIKQKLTK-QEEEKQILKQDFETL 819

Query: 1420 QERPRVQNQVILEE-NTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ 1478
             +  ++Q++ +     TT+   Q    + +A + EL   K KL +++  LK         
Sbjct: 820  SQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK------ 873

Query: 1479 KDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEED 1537
                S  EKE +  KA + DL+ TC E++ ++++    + K Q+E   L+  +    E++
Sbjct: 874  ----SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE---LKKSLE--KEKE 924

Query: 1538 SISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1597
            +   LKL  LN  QE++ Q   T+KQ     Q++  N+ +     + K +Q++    EL 
Sbjct: 925  ASHQLKL-ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983

Query: 1598 ----QKNSQNQEKLQELNQRLTEMLCQKEK--------EPGNSALEE-------REQEKF 1638
                QK     +  Q+L Q   E+  +KEK        E      ++       RE E  
Sbjct: 984  IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043

Query: 1639 NLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ----ENHLLKDELEKMKQL-HRCP 1693
              +++L+  + + S     L +  +++  Q  ++Q+    +  L +D  +K +QL  RC 
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103

Query: 1694 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1753
             L D Q+         EK LKEKE ++E          KS L E      +QE K     
Sbjct: 1104 ALQDIQK---------EKSLKEKELVNE----------KSKLAEIEEIKCRQE-KEITKL 1143

Query: 1754 SASLKSQLVASQEKVQNLEDT-----VQNVNLQ--MSRMKSDLRVTQQEKEALKQEVMSL 1806
            +  LKS  + S +++ NL+D       Q + LQ     +K+ +   ++ ++ LK +V   
Sbjct: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKE 1203

Query: 1807 HKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNT 1866
             ++L+         E     + LH++ K        H  NE +  L  +   L   +   
Sbjct: 1204 EEELKK--------EFIEKEAKLHSEIKEKEVGMKKHEENEAK--LTMQITALNENLGTV 1253

Query: 1867 KAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-------DQFQKEQ 1919
            K E   S+ +V +LE        +      T+   + E+ +L   C       ++ Q + 
Sbjct: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKV 1313

Query: 1920 SPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1952
                RK+    +  QEL     EN+ L+ K  +
Sbjct: 1314 LELQRKLDNTTAAVQELGR---ENQSLQIKHTQ 1343



 Score =  164 bits (415), Expect = 9e-40
 Identities = 291/1350 (21%), Positives = 568/1350 (42%), Gaps = 241/1350 (17%)

Query: 367  AEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD------HHAAIERRNEYNLR 420
            AE++ L +++++   E   ++   D  E+  + +A+E+ D         ++    E  + 
Sbjct: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194

Query: 421  KLDEEYKER---IAALKNEL------------RKEREQILQQAGKQRLELEQEIEKAKTE 465
            +L EE  +    I  LK EL            +KE  Q+        LE E+E EK K E
Sbjct: 195  RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254

Query: 466  ENYIRDRLALSLKENSRLENELLENAEKLAEY-----------ENLTNKLQRNLENVLAE 514
               ++ + A S    S+L +EL +  +++A Y             LT K Q   EN+L +
Sbjct: 255  CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314

Query: 515  K--FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 572
            +  +  L+    E  + ++ +    ++ +  C+ LQ ++   ++ L     +     L  
Sbjct: 315  EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-----LSE 369

Query: 573  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 632
            K   +++++     +E ++     E   L    E        KEQH        L+L+ +
Sbjct: 370  KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE-------KEQH-------GLQLQSE 415

Query: 633  VRHYEKQLDETVVSCKKAQENMKQRHENETHTL---EKQISDLKNEIAELQGQ----AAV 685
            +     +L ET     +A   +K++ +  +  L   E+Q++DL+ +++ L+ Q       
Sbjct: 416  INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475

Query: 686  LKEAHH--EATCRHEEEKKQLQ----VKLEEEKTHLQEKLRL-----QHEMELKARLTQA 734
              E  H  + T +  +E++ LQ     KL E +  L++ LR      Q    L+A L ++
Sbjct: 476  STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535

Query: 735  QAS---FEREREGLQSSAWTEEKVRGLTQELEQFH---QEQLTSLVEK-------HTLEK 781
            + +    E+ERE L +     E    +  +L++ +   QEQ+T L EK       H   +
Sbjct: 536  KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595

Query: 782  EELRKELLEK--HQRELQEGREKMETECNRRTSQIEAQFQSDCQ---KVTERCESALQSL 836
            E L  ++ E+  H R  Q+    +ET  N   SQ+    +   Q   ++  + E  L S 
Sbjct: 596  ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE-LLLSA 654

Query: 837  EGRYRQELKDLQ----------EQQREEKSQWEFEKDELTQECAEAQE---LLKETLKRE 883
            E     +  DLQ          + +++E ++   + D++T +  + QE    L+  LK  
Sbjct: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714

Query: 884  KTTSLVLTQEREMLEKTYKE-HLNSMVVE--RQQLLQDLEDLRNVS---ETQQSLLSDQI 937
            K   L L Q+ E LE   K+   +S+ V+  ++Q LQDL+  R ++   E + + LS Q+
Sbjct: 715  KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774

Query: 938  ---LELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 994
                E+ SS + +L+++ E L      ++L  Q  E+  ++ D E     +K+   E  +
Sbjct: 775  EMEKEIVSSTRLDLQKKSEAL--ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832

Query: 995  KATCETADRERAEMS-----TEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
            +      + ++ +M      TE+S ++ K+ ++  +      L++      +E  +G  A
Sbjct: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS------LKNSKSEFEKENQKGKAA 886

Query: 1050 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEIS-RLQQRLQKLEPGLVMSSCL 1108
            +  L++  + L+    V +      ++ +K++++   E S +L+  L  ++  L+ +   
Sbjct: 887  ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ-- 944

Query: 1109 DEPATEFFGNTAEQTEPFLQQ-----NRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1163
                     NT +Q E   QQ     N  KQ     ++ + +   + ++  L  T   + 
Sbjct: 945  ---------NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995

Query: 1164 QRQEV--KIEESEASVEGFSELENSEETRTESW-ELKNQISQLQEQLMMLCADCDRASEK 1220
             +Q++    +E  A  E  S L+N+ E   E++ +L++     + +L+    D     EK
Sbjct: 996  LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055

Query: 1221 ----KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEA 1276
                ++DL+ + + +  + K+++ +  A      L +D +++   LQE  + ++    E 
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAK---ATLEQDSAKKEQQLQERCKALQDIQKEK 1112

Query: 1277 LENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQ 1336
                KEL        +E  K+ E+ E     EK   E+   NEEL         K+E ++
Sbjct: 1113 SLKEKELV-------NEKSKLAEIEEIKCRQEK---EITKLNEELK------SHKLESIK 1156

Query: 1337 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG 1396
            E              + NL+   D   L + Q L E   +  S+   +E+ K+  Q L  
Sbjct: 1157 E--------------ITNLK---DAKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQIL-- 1196

Query: 1397 NTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELEL 1456
                                         ++QV  EE      F +K  +  + I E E+
Sbjct: 1197 -----------------------------KDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227

Query: 1457 EKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES 1516
               K +E   KL  ++T L             E L  +  + Q      Q++V  L  ++
Sbjct: 1228 GMKKHEENEAKLTMQITAL------------NENLGTVKKEWQ----SSQRRVSELEKQT 1271

Query: 1517 EKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1576
            + L+ E ++L  E T  N +D    L    L G  E      E ++ +   +Q+ ++N  
Sbjct: 1272 DDLRGEIAVL--EATVQNNQDERRALLERCLKGEGE-----IEKLQTKVLELQRKLDNTT 1324

Query: 1577 KQISELKIKNQQLDLENTE-LSQKNSQNQE 1605
              + EL  +NQ L +++T+ L++K +++ E
Sbjct: 1325 AAVQELGRENQSLQIKHTQALNRKWAEDNE 1354



 Score =  162 bits (410), Expect = 3e-39
 Identities = 268/1331 (20%), Positives = 566/1331 (42%), Gaps = 229/1331 (17%)

Query: 841  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 900
            RQE++DLQ   +EEK    +  +EL +E  + Q L ++  K +    LV     E+    
Sbjct: 89   RQEVQDLQASLKEEK----WYSEELKKELEKYQGLQQQEAKPD---GLVTDSSAEL---- 137

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 960
              + L   + E Q    +++ ++++ E + + L+ +I ++KS +  E   RE        
Sbjct: 138  --QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE-------- 187

Query: 961  SEQLASQRLERLEMEHDQER---QEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1017
                A Q++ RL  E ++E    Q++ ++LL    I          + A +  E+ ++Q+
Sbjct: 188  ---AAEQKVTRLTEELNKEATVIQDLKTELLQRPGI---------EDVAVLKKELVQVQT 235

Query: 1018 KIKEMQ-QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ 1076
             +  M  +       L+  C+ +  +    +  +S L+                      
Sbjct: 236  LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR---------------------- 273

Query: 1077 AVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1136
               E  K   E++   Q LQKL+  +   +  ++  TE   N  ++ + + +       E
Sbjct: 274  --SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE---NLLKKEQDYTKLEEKHNEE 328

Query: 1137 GVTRRHVLS-----DLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRT 1191
             V+++++ +     DL+  +++   S   +S+ R  V++ E   + +     E   E  T
Sbjct: 329  SVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK--EELSEVET 386

Query: 1192 ESWELKNQISQLQEQLMMLCADCDRASEKKQ---DLLFDVSVLKKKLKMLERIPEASPKY 1248
            +   LK +  QLQ+Q            EK+Q    L  +++ L  KL   ER        
Sbjct: 387  KYQHLKAEFKQLQQQ----------REEKEQHGLQLQSEINQLHSKLLETER-------- 428

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1308
                  +   +  L+E+ ++   +  +  +   +L  ++ RL+++LK  E+VT +   L+
Sbjct: 429  -----QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK--EKVTNS-TELQ 480

Query: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRC----DCCLWEASLENLEIEPDGNIL 1364
               D+ K +++E   L      K+ + Q  + Q      D      +LE L  +   NI 
Sbjct: 481  HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540

Query: 1365 QLNQTLEECVPRVRSVH---HVIEECKQENQYL-EGNTQLLEKVKAHEIAWLHGTIQTHQ 1420
             L +  E+   ++++      V+ + +++N  L E  TQL EK+K           ++H+
Sbjct: 541  LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS--------ESHK 592

Query: 1421 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELE----KTKLQELTRKLKERVTILV 1476
            +     +  + E+   L   QD+    + ++ EL  +    K K+ +L  ++K +  +L+
Sbjct: 593  QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652

Query: 1477 --------KQKDVLSH--------GEKEEELK----------AMMHDLQITCSEMQQKVE 1510
                    ++ D+ +H         +K++EL           A + D Q  CS+++  ++
Sbjct: 653  SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712

Query: 1511 LLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQK 1570
              + +   L+Q+   L  +I  L E DS+       +  S+E+  Q  +  +Q N  ++ 
Sbjct: 713  EYKEKYLSLEQKTEELEGQIKKL-EADSLE------VKASKEQALQDLQQQRQLNTDLEL 765

Query: 1571 MVENLKKQISELK--IKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNS 1628
                L KQ+   K  + + +LDL+         +  E L+ + Q+LT+   ++EK+    
Sbjct: 766  RATELSKQLEMEKEIVSSTRLDLQ---------KKSEALESIKQKLTKQ--EEEKQILKQ 814

Query: 1629 ALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
              E   QE     EEL   ++Q++        EL +VK++   +  E   +KD+L K+  
Sbjct: 815  DFETLSQETKIQHEELNN-RIQTTV------TELQKVKMEKEALMTELSTVKDKLSKVSD 867

Query: 1689 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1748
                  L + + +        +  + + E   +EL   +    +++L E +   +K+  +
Sbjct: 868  -----SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK--ELKKSLE 920

Query: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
              +  S  LK +L + QE++   ++T++    +  +++ ++   +Q  E  K+++ +L  
Sbjct: 921  KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 980

Query: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1868
            +L+ A                   QK    +KL   + +  Q L  E E++  +  N + 
Sbjct: 981  ELKIA-----------------VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE- 1022

Query: 1869 ELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQ 1928
                S+E  +QL+S+   +  + L        T Q+  S++ +    Q++      ++  
Sbjct: 1023 ---KSQETFKQLQSDFYGRESELL-------ATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072

Query: 1929 MNSLEQELETIH--LENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQAC 1986
             N L QEL+T    LE +  KK+Q +L E+   +Q ++   +        + +L+ +   
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQ-QLQERCKALQDIQKEKSLK------EKELVNE--- 1122

Query: 1987 PMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQK 2046
                + +  +++    + E+    L EEL++   E+     N +    ++ ++ +E++ K
Sbjct: 1123 ----KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGK 1178

Query: 2047 LKLVKRLL-QEKVNQ--LKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKN 2103
               +K  + QEK NQ  LK+Q+ K  + + + K+   + A+L   ++  E   K  E+  
Sbjct: 1179 ADSLKAAVEQEKRNQQILKDQVKK--EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENE 1236

Query: 2104 YLLEEKIASLS 2114
              L  +I +L+
Sbjct: 1237 AKLTMQITALN 1247



 Score =  136 bits (342), Expect = 3e-31
 Identities = 221/1076 (20%), Positives = 466/1076 (43%), Gaps = 142/1076 (13%)

Query: 1147 LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQL--- 1203
            L+  E +  G    SS + Q ++ +  EA  E F+  +  +    ++ +L  +I+ +   
Sbjct: 119  LQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSK 178

Query: 1204 -----------QEQLMMLCADCDRASEKKQDL---------LFDVSVLKKKLKMLERIPE 1243
                       ++++  L  + ++ +   QDL         + DV+VLKK+L  ++ + +
Sbjct: 179  YDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMD 238

Query: 1244 ASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL--------- 1294
                 +       RE++ L++E + ++++Y  +     +L +E+ +   E+         
Sbjct: 239  NMTLER------ERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQK 292

Query: 1295 ---------KKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCD 1344
                     +K + +TE  L  E+ Y +++ ++ E +V    +Q  + +      Q +  
Sbjct: 293  LKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSR 352

Query: 1345 CCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1404
                E SL  + +E         +  EE         H+  E KQ  Q  E   Q   ++
Sbjct: 353  LSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQL 412

Query: 1405 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQEL 1464
            ++ EI  LH  +    ER   +    L+E   L    +K    +  +A+L+L+ ++L+E 
Sbjct: 413  QS-EINQLHSKL-LETERQLGEAHGRLKEQRQLSS--EKLMDKEQQVADLQLKLSRLEEQ 468

Query: 1465 TRKLKERVTILVKQKDVLSHGEKEEE---------LKAMMHDLQITCSEM---QQKVELL 1512
             ++     T L  Q D      +E++         L+   +DL+    ++    QK++ L
Sbjct: 469  LKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL 528

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQE-------EMWQKTETVKQEN 1565
                +K ++  S+L  E   L  +      +   LN  QE       ++ Q TE +K ++
Sbjct: 529  EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 588

Query: 1566 AAVQKMVENLKKQISELKI-----KNQQLDLENT--ELSQKNSQNQEKLQELNQRL---T 1615
             + ++  ENL  Q+ E K      +++ L LE +  EL+ + ++++EK+ +L+ ++   T
Sbjct: 589  ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648

Query: 1616 EMLCQKEK-------------EPGNSALEEREQEKFNLKEELER--CKVQSSTL-VSSLE 1659
            E+L   E              +   +AL++++QE   +  +L++   K+Q      S LE
Sbjct: 649  ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLE 708

Query: 1660 AELSEVKIQTHIVQQENHLLKDELEKMK------QLHRCPDLSDFQQK--ISSVLSYNEK 1711
            + L E K +   ++Q+   L+ +++K++      +  +   L D QQ+  +++ L     
Sbjct: 709  SHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRAT 768

Query: 1712 LLKEKEALSEELNSC--VDKLAKSSLLEHRIATMKQEQKSWEHQSASLKS--QLVASQEK 1767
             L ++  + +E+ S   +D   KS  LE    ++KQ+    E +   LK   + ++ + K
Sbjct: 769  ELSKQLEMEKEIVSSTRLDLQKKSEALE----SIKQKLTKQEEEKQILKQDFETLSQETK 824

Query: 1768 VQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGG--KSWAPEIATH 1825
            +Q+ E     +N ++    ++L+  + EKEAL  E+ ++  +L       K+   E    
Sbjct: 825  IQHEE-----LNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879

Query: 1826 PSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLL 1885
                 NQ+ + +   L+    E +  L  + E      +  K  L   +E   QL+  L 
Sbjct: 880  -----NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934

Query: 1886 PKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEG 1945
               ++ +    T+   E+E+  L+   ++ ++    + +K  Q+ +L+ EL+   L+   
Sbjct: 935  SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS---SEQKKKQIEALQGELKIAVLQKTE 991

Query: 1946 LKKK-QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQA 2004
            L+ K Q +L +   E+   +   +   + +    +  +Q       RE  L   RQ L++
Sbjct: 992  LENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS 1051

Query: 2005 --ERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLK 2062
              E+++   ++ + NR        GNQ +L+  ++     +EQ     ++ LQE+   L+
Sbjct: 1052 VEEKLSLAQEDLISNRNQI-----GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ 1106

Query: 2063 E-QLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKN-YLLEEKIASLSNI 2116
            + Q  K+ K     K+L  E ++L +  E+  +++K   K N  L   K+ S+  I
Sbjct: 1107 DIQKEKSLKE----KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI 1158



 Score =  100 bits (249), Expect = 2e-20
 Identities = 194/889 (21%), Positives = 364/889 (40%), Gaps = 165/889 (18%)

Query: 1280 NKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENE--ELNVLVLR-----LQGKI 1332
            N E ++E F     +K +    E F   E  +D         E N+ + R     L+ ++
Sbjct: 33   NNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEV 92

Query: 1333 EKLQESVVQRCDCCLWEAS-----------LENLEIEPDGNILQLNQTLEECVPRVRSVH 1381
            + LQ S+ +      W +            L+  E +PDG +   +  L+       S+ 
Sbjct: 93   QDLQASLKEE----KWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQ-------SLE 141

Query: 1382 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQ 1441
              +EE + EN  ++    L E+ KA ++A     I++  +  R   +   ++ T L    
Sbjct: 142  QQLEEAQTENFNIKQMKDLFEQ-KAAQLATEIADIKSKYDEERSLREAAEQKVTRLT--- 197

Query: 1442 DKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQIT 1501
                       EL  E T +Q+L  +L +R  I    +DV    ++  +++ +M ++ + 
Sbjct: 198  ----------EELNKEATVIQDLKTELLQRPGI----EDVAVLKKELVQVQTLMDNMTL- 242

Query: 1502 CSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETV 1561
              E +++ E L+ E +KLQ + +         + E +IS L+     G QE         
Sbjct: 243  --ERERESEKLKDECKKLQSQYA---------SSEATISQLRSELAKGPQE--------- 282

Query: 1562 KQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQK 1621
                  V   V+ L+K  S +            EL+QKN           Q LTE L +K
Sbjct: 283  ------VAVYVQELQKLKSSVN-----------ELTQKN-----------QTLTENLLKK 314

Query: 1622 EKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD 1681
            E++   + LEE+  E+   K+ ++    Q       L++ LS  +   H +  E     +
Sbjct: 315  EQD--YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372

Query: 1682 ELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSE---ELNSCVDKLAKSSLLEH 1738
              +K+K+     +LS+ + K   + +  ++L +++E   +   +L S +++L  S LLE 
Sbjct: 373  ATQKLKE-----ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL-HSKLLE- 425

Query: 1739 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLR--VTQ--- 1793
                    ++        LK Q   S EK+ + E  V ++ L++SR++  L+  VT    
Sbjct: 426  -------TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478

Query: 1794 ------------QEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKL 1841
                        QE++AL+Q   +  ++ QN   +    +I      + N +  L   K 
Sbjct: 479  LQHQLDKTKQQHQEQQALQQSTTAKLREAQN-DLEQVLRQIGDKDQKIQNLEALLQKSK- 536

Query: 1842 DHLMNEEQQLLWQENERLQTMVQNTKAE---LTHSREKVRQLESNLLPKHQKHLNPSGTM 1898
                 E   LL +E E L   +Q  + E   L   +EK   L+  +    +K  N S   
Sbjct: 537  -----ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS--- 588

Query: 1899 NPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLM 1958
               E  K + +   DQ Q++++       ++ SLE  +  ++ +    K+K  +LD Q+ 
Sbjct: 589  ---ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645

Query: 1959 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE----- 2013
                L  +A  + +    DLQ     A   +  +Q  +L +   Q +++   LQ+     
Sbjct: 646  AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ-QELNKITTQLDQVTAKLQDKQEHC 704

Query: 2014 -ELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKAD 2072
             +LE+   E      + EQ    +E ++ ++E     VK   ++ +  L++Q   NT   
Sbjct: 705  SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT--- 761

Query: 2073 AMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVRNLT 2121
                DL +   +L K LE+    ++        L++K  +L +I + LT
Sbjct: 762  ----DLELRATELSKQLEM---EKEIVSSTRLDLQKKSEALESIKQKLT 803


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score =  167 bits (423), Expect = 1e-40
 Identities = 345/1694 (20%), Positives = 696/1694 (41%), Gaps = 259/1694 (15%)

Query: 369  IRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKE 428
            + H  ER+    RE + LR +L+K      L A    +    I +     ++      KE
Sbjct: 61   LSHSQERLVNETRECQSLRLELEKLNN--QLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118

Query: 429  RIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKE------NSR 482
             + A K +L +  E++ Q+      ++++  EK K E N  +  L L L E      + +
Sbjct: 119  ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK-ESNTTKGELQLKLDELQASDVSVK 177

Query: 483  LENELLENAEKLAEYEN--LTNKLQRNLENVLA---EKFGDLDPSSAEFFLQEE---RLT 534
               + LE  ++L   +N  L  +L+   + +LA   EK  ++         ++E   RL 
Sbjct: 178  YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE 237

Query: 535  QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKN-------------SPSEEVE 581
            +  N  +     LQ  V++L ++L+E + Q   +     N             S +++ E
Sbjct: 238  EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297

Query: 582  ANSG----GIEPEHGLGSEECNPLNMSIEAELV-IEQMKEQHHRDICCLRLELEDKVRHY 636
            A S      +E  H L  +E    N +I+  L+ +EQ K+Q  +       E+ +K+   
Sbjct: 298  AKSNELTRAVEELHKL-LKEAGEANKAIQDHLLEVEQSKDQMEK-------EMLEKIGRL 349

Query: 637  EKQLDETVVSCKKAQENMKQRHENETHTLEK-------------QISDLKNEIAELQGQA 683
            EK+L+         +       E E   +               ++++L N   E Q Q 
Sbjct: 350  EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL 409

Query: 684  AVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEM-ELKARLTQAQASFERER 742
             + K  +       +E  K+++ K    K   +E  R Q  +  L  +L QA    +R +
Sbjct: 410  LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQ 469

Query: 743  EGL-----QSSAWTEE-------------KVRGLTQELEQ------FHQEQLTS------ 772
            E       QSS    +             ++R L  ELE+         E+++S      
Sbjct: 470  EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529

Query: 773  --LVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTE--- 827
              ++ +H +    + +EL +++QR L   RE  ET    R  Q     ++   K+TE   
Sbjct: 530  SEVISQHLVSYRNI-EELQQQNQRLLVALRELGETR--EREEQ-----ETTSSKITELQL 581

Query: 828  RCESALQSLEG--RYRQELKDLQEQQREEKSQWEFEKDELTQECA--EAQEL----LKET 879
            + ESAL  LE   + RQ    L +    ++  +     + T       A  L    L  T
Sbjct: 582  KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641

Query: 880  LKREKTTSLVLTQER-EMLEKTYKEHLNSMVVERQQLLQDLE----DLRNVSETQQSLLS 934
             KR  T+  V T     ++E T      + + + Q++ ++ +    +   +   Q   L 
Sbjct: 642  PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701

Query: 935  DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 994
            +Q+ +L+S + +   + +            AS+R E L+   +  R+E+ S     E   
Sbjct: 702  EQVTDLRSQNTKISTQLD-----------FASKRYEMLQDNVEGYRREITS---LHERNQ 747

Query: 995  KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGDGALSLL 1053
            K T  T  +E+         + +  ++++ A   L++ +   + + +E E+     + L 
Sbjct: 748  KLTATTQKQEQI--------INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLS 799

Query: 1054 QQGEQLL-EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV-MSSCLDEP 1111
            QQ E LL E+ G  LL       Q + E  +  T+  RL  +++KLE  +  +   L+  
Sbjct: 800  QQRESLLAEQRGQNLLLTNLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858

Query: 1112 ATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHV-LSDLEDDEVRDLGSTGTSSVQRQEVKI 1170
              +    T       L   R  Q++  T  H+   +L  +  +++ +T    +   EV++
Sbjct: 859  VEQRHTLTRNLDVQLLDTKR--QLDTETNLHLNTKELLKNAQKEI-ATLKQHLSNMEVQV 915

Query: 1171 EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSV 1230
                +   G  +  N E+      +L +Q+ Q +EQ+          ++ K+ L    S 
Sbjct: 916  ASQSSQRTGKGQPSNKEDVD----DLVSQLRQTEEQV----------NDLKERLKTSTSN 961

Query: 1231 LKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRL 1290
            +++   M+  + E+  K K + E+V +  +   +E    +T+ ++ L    E+  E   L
Sbjct: 962  VEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL---MEVEKEKQEL 1018

Query: 1291 QDELKKMEEVTETFLS-LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1349
            QD+ ++  E  E  LS L+K+   V+ E +E            ++ +    ++    +  
Sbjct: 1019 QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078

Query: 1350 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1409
             +    E+      ++  Q  +E V ++ SV   +EE  Q+ +     +QLLE     + 
Sbjct: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE-----SQLLEC----KA 1129

Query: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1469
            +W        +ER R+               +D+  +      +LE +   L +   KL 
Sbjct: 1130 SW--------EERERM--------------LKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167

Query: 1470 ERVTILVKQK-------DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQE 1522
            ++V   VK+         +   G+ +E++  ++  ++      + + E+ + ES + +Q 
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQR 1227

Query: 1523 NSILRNEITTLNEEDSISNLKL---GTLNGSQEEMWQKTET---VKQENAAVQKMVENLK 1576
              +L  E+  L +  +    K+          EE+ +KTET   V + N  +++  E L+
Sbjct: 1228 VELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLE 1287

Query: 1577 KQISELKIKNQQLDLE-------NTELSQKNS--QNQEKLQE--------LNQRLTEMLC 1619
            + + +++ K ++L+L+       N ELS+K+   Q ++KL E         NQ L     
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK 1347

Query: 1620 QKEKEPGNSALEERE----------QEKFNLKEELERCKVQ---SSTLVSSLEAELSEVK 1666
              + E     L E+E          +E   LK E+ R       +  L+ SL+ +L++V+
Sbjct: 1348 DPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVR 1407

Query: 1667 IQTHIVQQE-NHLLKDELEKMKQLHRCPDLSD-FQQKISSVLSYNEKLLKEKEALSEELN 1724
             +   +Q++ +  + D  EK+K + +   +   ++ +   + +  +K+++     S +  
Sbjct: 1408 TEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQ 1467

Query: 1725 SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSR 1784
                 + +   L+  +   + + KS E Q  +L+  L   + + +NL++    +  ++SR
Sbjct: 1468 EQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527

Query: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNA--GGKSWAPEIATHPSGLHNQQKRLSWDKLD 1842
            ++ DL+    ++E L+Q++    ++ + A    KS   +IA H +G+ +Q       K +
Sbjct: 1528 LRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS---KIA-HLAGVKDQ-----LTKEN 1578

Query: 1843 HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL-------NPS 1895
              + +    L Q+ + L   +   K++      ++ +LE  L    ++HL        PS
Sbjct: 1579 EELKQRNGALDQQKDELDVRITALKSQY---EGRISRLERELREHQERHLEQRDEPQEPS 1635

Query: 1896 GTMNPTEQEKLSLK 1909
              + P +Q +++LK
Sbjct: 1636 NKV-PEQQRQITLK 1648



 Score =  155 bits (391), Expect = 5e-37
 Identities = 335/1685 (19%), Positives = 698/1685 (41%), Gaps = 286/1685 (16%)

Query: 626  RLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 685
            R EL    +  + +L++ +   +   + +K RHE      E+Q  +++  ++    Q  +
Sbjct: 11   RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS--HSQERL 68

Query: 686  LKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGL 745
            + E     + R E EK   Q+K   EK + + ++     + ++++ T+ +   E E+  L
Sbjct: 69   VNETRECQSLRLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127

Query: 746  --------QSSAWTEEKVRGLTQELEQ-----------FHQEQLTSLVEKHTLEKEELRK 786
                    Q   +  E V+ L ++L++             + Q + +  K+  ++ E  K
Sbjct: 128  IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187

Query: 787  ELLEKHQREL----------------QEGREKMETECN-----RRTSQIEAQF------Q 819
            ELL      L                ++G E +E +CN        S++E Q        
Sbjct: 188  ELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSN 247

Query: 820  SDCQKVTERCESALQ-------SLEGRYRQELK---DLQEQQREEKSQWEFEKDELTQEC 869
               QK  E   + L+       S+E ++  EL     L    +      E + +ELT+  
Sbjct: 248  EHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAV 307

Query: 870  AEAQELLKETLKREKTTSLVLTQ--------EREMLEKTYK-----EHLNSMV--VERQQ 914
             E  +LLKE  +  K     L +        E+EMLEK  +     E+ N ++   +R+ 
Sbjct: 308  EELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKG 367

Query: 915  LLQDLEDLRNVSETQQSL-------------------LSDQILELKSSHKRELREREEVL 955
             +   E+L  +S T  ++                     DQ+L  K  +KR  +  +E++
Sbjct: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427

Query: 956  CQAGASEQLASQRLERLEMEHDQERQEMMSKLL--AMENIHKATCET--ADRERAEMSTE 1011
             +  A   +  +  +R E E  Q+    +S  L  AM+ I +   +T  A+++ + +  +
Sbjct: 428  KEVEAKAPILKR--QREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERD 485

Query: 1012 ISRLQSKIKEMQQATSPLSM---LQSGCQVIGEEEVEG---DGALSLLQQG-------EQ 1058
              R++ ++K++ Q    L M      G  VI +EEV       +  ++ Q        E+
Sbjct: 486  NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE 545

Query: 1059 LLEENGDVLLSLQRAHEQAVKENVK-MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFG 1117
            L ++N  +L++L+   E   +E  +  +++I+ LQ +L+     L       +   +   
Sbjct: 546  LQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVD 605

Query: 1118 NTAEQTEPF-LQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEAS 1176
            +   Q + + +  ++T  V        L D+         ST  +      V + ES  +
Sbjct: 606  SIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665

Query: 1177 VEGFSEL-------ENSEETRTESWELKN-QISQLQEQLMMLCADCDRASEKKQDLLFDV 1228
            +E  + L       EN ++ + E+ +++N Q+ +LQEQ+  L     R+   K     D 
Sbjct: 666  IEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDL-----RSQNTKISTQLDF 720

Query: 1229 SVLKKKLKML-ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV 1287
            +   K+ +ML + +     +   L+E   +     Q++ +++ T   +    N++L    
Sbjct: 721  A--SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778

Query: 1288 FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL---QGKIEKLQESVVQRCD 1344
             R ++  K+ E +  + + L +  + +  E    N+L+  L   QG +E+ +    QR  
Sbjct: 779  VRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRL- 837

Query: 1345 CCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE---NQYLEGNTQLL 1401
                 + +E LE E      +L   +E+     R++   + + K++      L  NT+ L
Sbjct: 838  ----SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKEL 893

Query: 1402 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1461
             K    EIA    T++ H     VQ   +  +++   G       ++  + +L  +  + 
Sbjct: 894  LKNAQKEIA----TLKQHLSNMEVQ---VASQSSQRTGKGQP--SNKEDVDDLVSQLRQT 944

Query: 1462 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1521
            +E    LKER+          +     E+ +AM+  L+ + ++ +Q  E +R   E   +
Sbjct: 945  EEQVNDLKERLK---------TSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK 995

Query: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
            E++  + ++     E      +L      Q++  +  E+++Q+ + ++K + +++ ++ E
Sbjct: 996  ESAEFQTQLEKKLMEVEKEKQEL------QDDKRRAIESMEQQLSELKKTLSSVQNEVQE 1049

Query: 1582 LKIKNQQLDLENTELSQKNSQNQEKL--QELNQRLTEMLCQKEKEPGNSALEEREQEKFN 1639
              ++     L N + ++++ Q Q K+  +  N+   E++          A +E+  +  +
Sbjct: 1050 -ALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMAS 1108

Query: 1640 LKEELE-----------RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKM-- 1686
            +++ LE            CK         L+ E+S+   +   ++++N LL D++EK+  
Sbjct: 1109 VRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD 1168

Query: 1687 ------KQLHRCP---DLSD---FQQKISSVLSY--NEKLLKEK---------------- 1716
                  K+  + P    LS+    Q++I  +L +   EK + E                 
Sbjct: 1169 KVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRV 1228

Query: 1717 EALSEELNSCVDKL-AKSSLLEHRIATMKQEQ---KSWEHQSASLKSQLVASQEKVQNLE 1772
            E L  EL    D L A+   ++    TM Q +   K  E  +  +++  +  +EK + LE
Sbjct: 1229 ELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEK-ERLE 1287

Query: 1773 DTVQNVNLQMSRMKSDLRVTQQEKEAL--KQEVMSLHKQLQNAGGKSWAPEIATHPSGLH 1830
              +Q +  ++ +++ D+   Q+    L  K  ++   K+L     K W          L 
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRW----KARNQHLV 1343

Query: 1831 NQQKRLSWDKLDHLMNEEQ------QLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1884
            +QQK    ++   L++E++      Q L +E  RL+  +  + A LT+++  ++ L+ +L
Sbjct: 1344 SQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDL 1403

Query: 1885 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE 1944
                          N    EK +++++ D    +     + ++Q+  + +  +T   + E
Sbjct: 1404 --------------NKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKT---QYE 1446

Query: 1945 GLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQA 2004
             LK +Q K+ E          T+  S   H       Q+Q    V  ++  +L+  L QA
Sbjct: 1447 ELKAQQDKVME----------TSAQSSGDH-------QEQ---HVSVQEMQELKETLNQA 1486

Query: 2005 ERINQHLQEELEN---RTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKV--- 2058
            E  ++ L+ ++EN     SE  T   N       ++E+ ++++ +L  +++ LQ++    
Sbjct: 1487 ETKSKSLESQVENLQKTLSEKETEARN-------LQEQTVQLQSELSRLRQDLQDRTTQE 1539

Query: 2059 NQLKEQLC----KNTKADAMVKDLYVENA----QLLKALEVTEQRQKTAEKKNYLLEEKI 2110
             QL++Q+     K  KA    K      A    QL K  E  +QR    +++   L+ +I
Sbjct: 1540 EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRI 1599

Query: 2111 ASLSN 2115
             +L +
Sbjct: 1600 TALKS 1604



 Score =  116 bits (291), Expect = 2e-25
 Identities = 217/1055 (20%), Positives = 461/1055 (43%), Gaps = 169/1055 (16%)

Query: 307  VERILDTWQEEGIEN----SQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAAL 362
            ++ I + +++E  EN    ++++ K  +   D     T+++  L+      +  + Q  +
Sbjct: 675  LQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLD--FASKRYEMLQDNV 732

Query: 363  ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV---DDHHAAIERRNEYNL 419
              ++ EI  L ER        +KL +   K E++ + M  ++   ++  A  E R E NL
Sbjct: 733  EGYRREITSLHER-------NQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAE-NL 784

Query: 420  RKLDEEYKERIAALKNELRKEREQILQQAGKQRLEL------EQEIEKAKTEENYIRDRL 473
            +K     KE +   +  L ++RE +L +   Q L L      +  +E+++TE    + RL
Sbjct: 785  KK----EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET---KQRL 837

Query: 474  ALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL 533
            +  ++   +LE+E+    +KL       + L RNL+  L +    LD  +      +E L
Sbjct: 838  SSQIE---KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894

Query: 534  TQMRNEYERQCRVL----------------------QDQVDELQSELEEYRAQGRVLRLP 571
               + E     + L                      ++ VD+L S+L +   Q   L+  
Sbjct: 895  KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER 954

Query: 572  LKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELED 631
            LK S S   +  +     E  L  E+               Q+ E+  ++I    + L++
Sbjct: 955  LKTSTSNVEQYQAMVTSLEESLNKEK---------------QVTEEVRKNI---EVRLKE 996

Query: 632  KVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHH 691
                ++ QL++ ++  +K ++ ++        ++E+Q+S+LK  ++ +Q +   ++EA  
Sbjct: 997  SAE-FQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE---VQEALQ 1052

Query: 692  EATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT 751
             A+     E++  +   E+ K  ++ + + + E+ L A   +A    +  +E +   A  
Sbjct: 1053 RASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEA---LQAAKEQVSKMASV 1109

Query: 752  EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRK-----ELLEKHQRELQEGREKMETE 806
             + +   TQ+ E    E   S  E+  + K+E+ K     E LEK  R L +  EK+   
Sbjct: 1110 RQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS-- 1167

Query: 807  CNRRTSQIEAQFQSDCQ-KVTERCESALQSLE-GRYRQELKDLQEQQRE----EKSQWEF 860
             ++  + ++   Q      ++E  +S  Q LE  R+ +  K++ E + E    E  ++  
Sbjct: 1168 -DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226

Query: 861  EKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHL----NSMV-VERQQL 915
              + L +E  E Q+ L    ++ + T+  + Q  E+++KT   ++    N M+  E+++L
Sbjct: 1227 RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERL 1286

Query: 916  LQDLEDLR-NVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM 974
             QDL+ ++  V + +  +L  Q    + S K  + + E+ L +       A  R + L  
Sbjct: 1287 EQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKA--RNQHLVS 1344

Query: 975  EHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1034
            +      E   KLL+ + +H    +       +++ EI RL++   E+ ++ + L+  Q+
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQ-------QLTEEIGRLKA---EIARSNASLTNNQN 1394

Query: 1035 GCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR 1094
              Q + E+       L+ ++  ++ ++++ D  +         ++E VK  T++ ++ +R
Sbjct: 1395 LIQSLKED-------LNKVRTEKETIQKDLDAKII-------DIQEKVKTITQVKKIGRR 1440

Query: 1095 LQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRD 1154
             +                T++    A+Q +       + Q  G  +   +S  E  E+++
Sbjct: 1441 YK----------------TQYEELKAQQDK---VMETSAQSSGDHQEQHVSVQEMQELKE 1481

Query: 1155 LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADC 1214
                   ++ + E K +  E+ VE   +  + +E  TE+  L+ Q  QLQ +L  L  D 
Sbjct: 1482 -------TLNQAETKSKSLESQVENLQKTLSEKE--TEARNLQEQTVQLQSELSRLRQDL 1532

Query: 1215 -DRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLL---YEDVSRENDCLQEELRMME 1270
             DR ++++Q       + +K+ K  + I  A  K   L    + +++EN+ L++    ++
Sbjct: 1533 QDRTTQEEQ---LRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589

Query: 1271 TRYDE------ALENNKELTAEVFRLQDELKKMEE 1299
             + DE      AL++  E    + RL+ EL++ +E
Sbjct: 1590 QQKDELDVRITALKSQYE--GRISRLERELREHQE 1622



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 217/1083 (20%), Positives = 429/1083 (39%), Gaps = 163/1083 (15%)

Query: 1151 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLM 1208
            E  +L     S   + E  + + ++ ++G        +  +E   +E++ ++S  QE+L+
Sbjct: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69

Query: 1209 MLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRM 1268
                +C     + + L   +  L +K K LE   + +   +  +     E +  + +L  
Sbjct: 70   NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129

Query: 1269 METRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1328
               R  + LE    LT +V RL ++LK   E   T   L+   DE++  +  +     RL
Sbjct: 130  TNERLSQELE---YLTEDVKRLNEKLK---ESNTTKGELQLKLDELQASDVSVKYREKRL 183

Query: 1329 QGKIEKL-QESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEEC 1387
            + + E L  ++     +       L  L  E    IL+L   LE     V  +   +   
Sbjct: 184  EQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGL 243

Query: 1388 KQENQYLEGNTQ-LLEKVK------------------AH-EIAWLHGTIQTHQERPRVQN 1427
            K  N++L+ + + LL K+K                  AH +++ L+ +     E    + 
Sbjct: 244  KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303

Query: 1428 QVILEENTTLL---GFQDKHFQHQATIAEL---ELEKTKLQELTRKLKERVTILVKQKDV 1481
               +EE   LL   G  +K  Q      E    ++EK  L+++ R  KE    L    D+
Sbjct: 304  TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE----LENANDL 359

Query: 1482 LSHGEK------EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT--- 1532
            LS  ++      EEEL AM          ++  ++L    +  ++ ++ +L  ++     
Sbjct: 360  LSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI 419

Query: 1533 ---LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
               L+E       K   L   +EE     E  ++  A++   +E   K+I  L+    + 
Sbjct: 420  NKYLDEIVKEVEAKAPILKRQREEY----ERAQKAVASLSVKLEQAMKEIQRLQEDTDKA 475

Query: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649
            + +++ L + N + + ++++L+Q++  +L + E+  GN  + + E    ++    E   V
Sbjct: 476  NKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE---V 532

Query: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1709
             S  LVS    E  + + Q  +V      L +  E+ +Q      +++ Q K+ S L+  
Sbjct: 533  ISQHLVSYRNIEELQQQNQRLLVALRE--LGETREREEQETTSSKITELQLKLESALTEL 590

Query: 1710 EKLLKEKEALSEELNSCVDK-----------------LAKSSLLEHRIAT---------- 1742
            E+L K ++   + ++S V +                 L  SSL +  +A+          
Sbjct: 591  EQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQT 650

Query: 1743 ---------------------MKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQ 1781
                                 +KQ Q+ +E+             E+++ L++ V ++  Q
Sbjct: 651  VSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQ 710

Query: 1782 MSRMKSDL-------RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1834
             +++ + L        + Q   E  ++E+ SLH++                     NQ+ 
Sbjct: 711  NTKISTQLDFASKRYEMLQDNVEGYRREITSLHER---------------------NQKL 749

Query: 1835 RLSWDKLDHLMNEEQQLLWQENERL---QTMVQNTKAE---LTHSREKVRQLESNLLPKH 1888
              +  K + ++N   Q L   NE+L   +   +N K E   L  S  ++ Q   +LL + 
Sbjct: 750  TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAE- 808

Query: 1889 QKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETI--HLENEGL 1946
            Q+  N   T   T Q  L         + E     R  SQ+  LE E+  +   LENE  
Sbjct: 809  QRGQNLLLTNLQTIQGILE--------RSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860

Query: 1947 KKKQV--KLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQA 2004
            ++  +   LD QL++ +    T T         L+  Q++   +      +++Q     +
Sbjct: 861  QRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSS 920

Query: 2005 ERINQ---HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQ--EKVN 2059
            +R  +     +E++++  S+    +     L   ++     VEQ   +V  L +   K  
Sbjct: 921  QRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK 980

Query: 2060 QLKEQLCKNTKADAMVKDLYVENAQLLKAL-EVTEQRQKTAEKKNYLLEEKIASLSNIVR 2118
            Q+ E++ KN   +  +K+      QL K L EV +++Q+  + K   +E     LS + +
Sbjct: 981  QVTEEVRKN--IEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKK 1038

Query: 2119 NLT 2121
             L+
Sbjct: 1039 TLS 1041



 Score = 37.0 bits (84), Expect = 0.21
 Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 38/152 (25%)

Query: 316  EEGIENSQEILKALDFSLDGNINLTELTLALENEL--------------------LVTKN 355
            E  +EN Q+ L   +       NL E T+ L++EL                    +  K 
Sbjct: 1494 ESQVENLQKTLSEKETEAR---NLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE 1550

Query: 356  SIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRN 415
               + A+ + K++I HL    DQ+ +E E+L+      ++ K  +               
Sbjct: 1551 EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDEL--------------- 1595

Query: 416  EYNLRKLDEEYKERIAALKNELRKEREQILQQ 447
            +  +  L  +Y+ RI+ L+ ELR+ +E+ L+Q
Sbjct: 1596 DVRITALKSQYEGRISRLERELREHQERHLEQ 1627


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  160 bits (406), Expect = 1e-38
 Identities = 308/1506 (20%), Positives = 615/1506 (40%), Gaps = 230/1506 (15%)

Query: 764  QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE--KMETECNRRTSQIEAQFQSD 821
            QF   +L   +      ++EL  EL E  +   ++  +   M+   +R     E Q  S 
Sbjct: 213  QFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASP 272

Query: 822  CQ-KVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET- 879
             + K  E      +SL  R  + LK  Q+  + EKSQ + + ++L++E  +    L+E  
Sbjct: 273  LEPKELEELRDKNESLTMRLHETLKQCQDL-KTEKSQMDRKINQLSEENGDLSFKLREFA 331

Query: 880  --LKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQD---LEDLRNVSETQQSLLS 934
              L++ +     LT+E     + + E    +  E    LQD   LE+   + + + S L 
Sbjct: 332  SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391

Query: 935  DQILELKSSHKRELRE-----------REEVLCQAGASEQLASQRLERLEMEHDQERQEM 983
            + + +L+ +  +E  E           ++E    A  + QL + R+E LE E  Q+    
Sbjct: 392  EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQA-RVEMLETERGQQE--- 447

Query: 984  MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQA---------------TSP 1028
             +KLLA E  H       + E+ ++S+ I+ LQS I  + QA               T+ 
Sbjct: 448  -AKLLA-ERGH------FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499

Query: 1029 LSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHE--QAVKENVKMAT 1086
            ++ L S    +     + D  L+ L+Q  Q  E+   +  +LQ+  +  Q ++  V+  +
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQ--QAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557

Query: 1087 EISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGVTRRHV- 1143
              S L+Q+ Q+L+          +   +     AE+ E  L++     KQ+E + +    
Sbjct: 558  --SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615

Query: 1144 -LSDLED-----DEVRDLGSTGTSSVQRQEV----KIEESEASVEGFSELENSEETRTES 1193
             L  L+      +E RD   T  +  QR++     K+EE +A VE           R E 
Sbjct: 616  KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE---------TARQEQ 666

Query: 1194 WELKNQISQLQEQL---MMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1250
             E + Q+++L+ QL        + +R +++K  L   +  LK+ LK+ +   E       
Sbjct: 667  HEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLE------- 719

Query: 1251 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1310
              E+  R  D L+E+ R +        E   E  + V + + E K++EE       LE  
Sbjct: 720  --EEKRRAADALEEQQRCIS-------ELKAETRSLVEQHKRERKELEEERAGRKGLEAR 770

Query: 1311 YDEVKIENEELNVLVLRLQGKIEKLQESVVQRCD-----CCLWEASLENLEIEPDGNILQ 1365
              ++   ++    ++ R   +    Q +    C+        W    E+ + E       
Sbjct: 771  LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830

Query: 1366 LNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTI----QTHQE 1421
              + L             ++E K++   +E +++L    + +E+A LH  +    Q  QE
Sbjct: 831  FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890

Query: 1422 RPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ--K 1479
            +  V+ Q + ++ +TL          Q  +A    E  +L+ L RK  E+     ++  K
Sbjct: 891  K-EVRAQKLADDLSTL----------QEKMAATSKEVARLETLVRKAGEQQETASRELVK 939

Query: 1480 DVLSHGEK-----EEELKAMMHDLQITCSEMQQKVELLRYESEKL-----------QQEN 1523
            +    G++     EE+        Q     M+++ E +  E E+L           Q+E 
Sbjct: 940  EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEER 999

Query: 1524 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET-VKQENAAVQKMVENLKKQISEL 1582
                 E+  L +E   +   L     ++ E+  + +  + ++      + E L   ++E 
Sbjct: 1000 GQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEK 1059

Query: 1583 KIKNQQL-DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKE----------------P 1625
            + K+Q+L  L   E +Q   +  E+L++  ++L E L +KEKE                P
Sbjct: 1060 EGKDQELAKLRGLEAAQ--IKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117

Query: 1626 GNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEK 1685
                LE    E   L+++ ++ + Q+ +L  SLEAE +    +   ++     L+++ ++
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177

Query: 1686 MKQLHRCPDLSDFQQKISS----VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA 1741
            +   H    L+  Q+++++    V  +++   + K  ++        K +  S LE  ++
Sbjct: 1178 LG--HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVS 1235

Query: 1742 TMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQ 1801
             + ++    E +S  LK  ++A  EK Q LE+ ++   L  +   S+     +   AL++
Sbjct: 1236 ILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR---LLQAETASNSARAAERSSALRE 1292

Query: 1802 EVMSLHKQL----------------QNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLM 1845
            EV SL ++                 Q    +    E+         +++ LS  +L+H  
Sbjct: 1293 EVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTS 1352

Query: 1846 NEE--QQLLWQENERLQTMVQNTKAELTHSRE--KVRQLESNLLPKHQKHLNPSGTMNPT 1901
             +    +LL  ++   Q   +   AE  H  E  + +Q    L  +  +     G + P 
Sbjct: 1353 TQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPL 1412

Query: 1902 EQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK--------QVKL 1953
             Q+    +R   Q + E++       Q++ L++    +  EN GL ++        +V+L
Sbjct: 1413 RQKVAEQERTAQQLRAEKASY---AEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVEL 1469

Query: 1954 DEQ----LMEMQHLRSTATP-------SPSPHAWDLQLLQQQ----ACPMVPREQFLQLQ 1998
            D+     + E+  +R+ A              A +L+++  +       ++   Q  Q +
Sbjct: 1470 DQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEE 1529

Query: 1999 RQLLQAE--------RINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV 2050
            RQ L A+        R      EEL  + ++++     Q+Q +  ++ +  E +Q+    
Sbjct: 1530 RQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQE---- 1585

Query: 2051 KRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKI 2110
             + LQ ++N+L+ QL +  +A         E+ +L   +E  +      +++N  L+E++
Sbjct: 1586 AQRLQAQLNELQAQLSQKEQA--------AEHYKL--QMEKAKTHYDAKKQQNQELQEQL 1635

Query: 2111 ASLSNI 2116
             SL  +
Sbjct: 1636 RSLEQL 1641



 Score =  160 bits (404), Expect = 2e-38
 Identities = 338/1582 (21%), Positives = 638/1582 (40%), Gaps = 254/1582 (16%)

Query: 341  ELTLALENELLVTKNS--------IHQAALASFKAEIRHLLERVDQVVREKE-----KLR 387
            EL LA   +LL  K++        I + AL + K     L  +  + +R+K      +L 
Sbjct: 234  ELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293

Query: 388  SDLDKAEKLKSLMASEVDDHHAAIERRN---EYNLRKLDEEYKERIAALKNELRKEREQI 444
              L + + LK+   S++D     +   N    + LR+     ++   AL NEL +E  + 
Sbjct: 294  ETLKQCQDLKT-EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDAL-NELTEEHSKA 351

Query: 445  LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL 504
             Q+  +++ +LE+E+  A  ++  + ++            NE+L+   KL++ E   ++L
Sbjct: 352  TQEWLEKQAQLEKELSAALQDKKCLEEK------------NEILQG--KLSQLEEHLSQL 397

Query: 505  QRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSE------- 557
            Q N      E  GD+        L++E  T   N  + Q RV   + +  Q E       
Sbjct: 398  QDNPPQEKGEVLGDVLQLET---LKQEAATLAANNTQLQARVEMLETERGQQEAKLLAER 454

Query: 558  --LEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELV-IEQM 614
               EE + Q   L   L++S S   +A     +     G+     +  S+ +EL  +   
Sbjct: 455  GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQV-ASLTSELTTLNAT 513

Query: 615  KEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKN 674
             +Q  +++  L+ + ++K    + QL +T+   ++A + ++ + E  + +L+++   LK 
Sbjct: 514  IQQQDQELAGLKQQAKEK----QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK- 568

Query: 675  EIAELQGQAAVLKEAHHEATCRHEEEK---------KQLQVKLEEEKTHLQEKLRLQHEM 725
            E+AE Q +A     A   AT   E E          KQL+  LE+EK    E L+ Q ++
Sbjct: 569  EVAEKQ-EATRQDHAQQLATAAEEREASLRERDAALKQLEA-LEKEKAAKLEILQQQLQV 626

Query: 726  ELKAR------LTQAQ---ASFEREREGLQSSAWT----EEKVRGLTQELE-QFHQEQLT 771
              +AR      +TQAQ   A   R+ E LQ+   T    + + +    ELE Q   EQ  
Sbjct: 627  ANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK 686

Query: 772  SLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCES 831
            +  ++   ++++  +E L+  +  L+  +  +E E  R    +E Q     Q+     ++
Sbjct: 687  ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQ-----QRCISELKA 741

Query: 832  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 891
              +SL  ++++E K+L+E++   K       +   Q+  EA +   E L+RE   ++   
Sbjct: 742  ETRSLVEQHKRERKELEEERAGRKGL-----EARLQQLGEAHQAETEVLRRELAEAMAA- 795

Query: 892  QEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSS---HKREL 948
                  + T +     +V E     +  ED +       ++  +Q++ LK      ++EL
Sbjct: 796  ------QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL 849

Query: 949  REREEVLC--QAGASEQLASQRLERLEMEHDQER--QEMMSKLLAMENIHKATCETADRE 1004
            +E +E +   ++ +  Q++ Q+ E  E+  +  R  Q++  K +  + +      T   +
Sbjct: 850  QEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD-DLSTLQEK 908

Query: 1005 RAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENG 1064
             A  S E++RL++ +++  +     S      +++ E    GD      +Q E L E+ G
Sbjct: 909  MAATSKEVARLETLVRKAGEQQETASR-----ELVKEPARAGD------RQPEWLEEQQG 957

Query: 1065 DVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTE 1124
                S Q A +   +E  +M  E+ RL+  L + +              E  G    +  
Sbjct: 958  RQFCSTQAALQAMEREAEQMGNELERLRAALMESQG----------QQQEERGQQEREVA 1007

Query: 1125 PFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEV---KIEESEASVEGFS 1181
               Q+    Q +    +   ++LE      L          QE     + E E   +  +
Sbjct: 1008 RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELA 1067

Query: 1182 ELENSEETRT-ESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER 1240
            +L   E  +  E  EL+  + QL+EQL         A ++K+      S    + +   R
Sbjct: 1068 KLRGLEAAQIKELEELRQTVKQLKEQL---------AKKEKEH----ASGSGAQSEAAGR 1114

Query: 1241 IPEASPKYKLLYEDVSR-ENDCL--QEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1297
                 PK + L  +VS+ E  C   QE+   +E   +    +  E  + +  LQ +L++ 
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEK 1174

Query: 1298 EEVTETFLSLEKSYDEVKIENEELNVLVLRLQ--GKIEKLQESVVQRCDCCLWEASLENL 1355
             +       L  S   +     EL     ++Q   K E   ++ V R      EA  +N 
Sbjct: 1175 AQ------ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGR---QEAERKNS 1225

Query: 1356 EIEP-DGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAW--- 1411
             I   +  +  LN+ + E     + +  ++    +++Q LE   +LL+   A   A    
Sbjct: 1226 LISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285

Query: 1412 ----LHGTIQT---HQERPRVQNQVILEENTT-----------LLGFQDKHFQHQATIAE 1453
                L   +Q+     E+ RV ++ + +E T+           L  +Q+K FQ +  ++ 
Sbjct: 1286 RSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALST 1345

Query: 1454 LELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLR 1513
            L+LE T  Q L       V+ L+  K +    + E+      H                R
Sbjct: 1346 LQLEHTSTQAL-------VSELLPAKHLCQQLQAEQAAAEKRH----------------R 1382

Query: 1514 YESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ---ENAAVQK 1570
             E E+ +Q    LR E+     E       LG L   ++++ ++  T +Q   E A+  +
Sbjct: 1383 EELEQSKQAAGGLRAELLRAQRE-------LGELIPLRQKVAEQERTAQQLRAEKASYAE 1435

Query: 1571 MVENLKKQISELKIKNQQL--------DLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1622
             +  LKK    L  +N+ L             EL Q   +  ++L  +       L + +
Sbjct: 1436 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ 1495

Query: 1623 KEPGNSALE------EREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQEN 1676
            +E  ++A E      + E  K  + EE +R + +   L + +E        Q  + Q+E 
Sbjct: 1496 REAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE--------QLEVFQREQ 1547

Query: 1677 HLLKDELEKMKQLHRCPDLSDFQQ-KISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSL 1735
                +EL K  +L      S  QQ K+ +V +   +  +E + L  +LN           
Sbjct: 1548 TKQVEELSK--KLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ-------- 1597

Query: 1736 LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE 1795
                 A + Q++++ EH    +        EK +   D  +  N ++      L   Q+E
Sbjct: 1598 -----AQLSQKEQAAEHYKLQM--------EKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644

Query: 1796 KEALKQEVMSLHKQLQNAGGKS 1817
             + L+ E   L  +LQ AG K+
Sbjct: 1645 NKELRAEAERLGHELQQAGLKT 1666



 Score =  149 bits (377), Expect = 2e-35
 Identities = 291/1470 (19%), Positives = 591/1470 (40%), Gaps = 174/1470 (11%)

Query: 362  LASFKAEIRHLLERVDQVVREKEKLRSD-LDKAEKLKSLMASEVDDHHAAIERRNEYNLR 420
            L  F + ++ L + ++++  E  K   + L+K  +L+  +++ + D    +E +NE    
Sbjct: 327  LREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC-LEEKNEILQG 385

Query: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480
            KL +  +E ++ L++   +E+ ++L     Q   L+QE          ++ R+ +   E 
Sbjct: 386  KLSQ-LEEHLSQLQDNPPQEKGEVLGDV-LQLETLKQEAATLAANNTQLQARVEMLETER 443

Query: 481  SRLENELLENA----EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQM 536
             + E +LL       E+  +  +L   LQ ++ N L++   +L+ +S        RLT  
Sbjct: 444  GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN-LSQAKEELEQASQA---HGARLTAQ 499

Query: 537  RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE 596
                  +   L   + +   EL   + Q +  +  L  +  ++ +A+ G       L S 
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559

Query: 597  ECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYE---KQLD----ETVVSCKK 649
                     E     E  ++ H + +     E E  +R  +   KQL+    E     + 
Sbjct: 560  LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619

Query: 650  AQENMKQRHE------NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQ 703
             Q+ ++  +E            +++ ++L  ++ ELQ      ++  HEA  +  E + Q
Sbjct: 620  LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679

Query: 704  L---QVKLEEEKTHLQEKLRLQHEME-LKARLTQAQASFEREREGLQSSAWTEEKVRGLT 759
            L   Q K  E++   QEK +LQ +++ LK  L   + S E E+   +++   EE+ R ++
Sbjct: 680  LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR--RAADALEEQQRCIS 737

Query: 760  QELEQFHQEQLTSLVEKHTLEKEELRKEL-----LEKHQRELQEGREKMETECNRRTSQI 814
            +      + +  SLVE+H  E++EL +E      LE   ++L E  +  ETE  RR    
Sbjct: 738  EL-----KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA-ETEVLRREL-- 789

Query: 815  EAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 874
             A+  +        CE  ++ +   +R+  +D Q+++ +  + ++ +   L +EC +A++
Sbjct: 790  -AEAMAAQHTAESECEQLVKEVAA-WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQ 847

Query: 875  LLKETLKR----EKTTSLVLTQEREMLEKTYK------EHLNSMVVERQQLLQDLEDLRN 924
             L+E  ++    E  + L +++++  L + +       + +    V  Q+L  DL  L+ 
Sbjct: 848  ELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE 907

Query: 925  -VSETQQSLLSDQILELKSSHKRELREREEVLCQAGA-----------------SEQLAS 966
             ++ T + +   + L  K+  ++E   RE V   A A                 S Q A 
Sbjct: 908  KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAAL 967

Query: 967  QRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQAT 1026
            Q +ER   +   E + + + L+  +   +      +RE A ++ E  R Q+ +   + A 
Sbjct: 968  QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027

Query: 1027 SPLSM-LQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMA 1085
            + L M LQ+    + E+ VE       L       E     L  L+      +KE  ++ 
Sbjct: 1028 AELEMRLQNA---LNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084

Query: 1086 TEISRLQQRLQKLEPGLVMSSCLDEPA---TEFFG---------------------NTAE 1121
              + +L+++L K E      S     A   TE  G                       A+
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144

Query: 1122 QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1181
              E  L+  R  + E  +    L    +++ ++LG + ++    Q  ++      V+  S
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQR-ELAAFRTKVQDHS 1203

Query: 1182 ELENSEET-----RTESWELKNQISQLQEQLMMLCADC-DRASEKKQDLLFDVSVLKKKL 1235
            + E+  +      R E+    + IS L+E++ +L     ++  E K+     ++  +K  
Sbjct: 1204 KAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263

Query: 1236 KMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE---ALEN-NKELTAEVFRLQ 1291
            K+ ER+     +        +  +  L+EE++ +    ++   A EN  +ELT++  R +
Sbjct: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323

Query: 1292 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1351
            +  ++++   E F   E++   +++E+     LV  L       Q+  +Q       +  
Sbjct: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ--LQAEQAAAEKRH 1381

Query: 1352 LENLEIEPDG------NILQLNQTLEECVP---RVRSVHHVIEECKQENQYLEGNTQLLE 1402
             E LE            +L+  + L E +P   +V       ++ + E         +L+
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441

Query: 1403 KVKAHEIAWLHGTIQTHQ----ERPRVQNQVILEENTTLLGFQDKHFQHQATI------- 1451
            K         HG +        ER  +  Q +  E   L   ++K+ Q  A +       
Sbjct: 1442 KA--------HGLLAEENRGLGERANLGRQFLEVE---LDQAREKYVQELAAVRADAETR 1490

Query: 1452 -AELELEKT----KLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQ 1506
             AE++ E      +L+ +T K +     +++++      E+ ++L A +  L++   E  
Sbjct: 1491 LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ--EERQKLTAQVEQLEVFQREQT 1548

Query: 1507 QKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENA 1566
            ++VE L  +     Q + + + ++  +  +   S  +   L     E+  +    +Q   
Sbjct: 1549 KQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAE 1608

Query: 1567 AVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG 1626
              +  +E  K      K +NQ+L  +   L Q   +N+E L+   +RL            
Sbjct: 1609 HYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE-LRAEAERLG----------- 1656

Query: 1627 NSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV---QQENHLLKD-E 1682
                 E +Q     KE  + C+   +  V SLEA+++    Q   +   Q     LK  E
Sbjct: 1657 ----HELQQAGLKTKEAEQTCR-HLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1711

Query: 1683 LEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1712
             +   QL    D  D   +  + LS   KL
Sbjct: 1712 PQAKPQLDLSIDSLDLSCEEGTPLSITSKL 1741



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 174/860 (20%), Positives = 350/860 (40%), Gaps = 104/860 (12%)

Query: 1337 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV------HHVIEECKQE 1390
            E+V+Q  DC ++   ++ +    +G  + L Q + E +  V S       H    EC   
Sbjct: 25   EAVLQLQDCSIFIKIIDRIHGTEEGQQI-LKQPVSERLDFVCSFLQKNRKHPSSPECLVS 83

Query: 1391 NQ-YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE-ENTTLLGFQDKHFQHQ 1448
             Q  LEG+   LE  K   +   H T+ +   R   Q +  ++ E   +L F   H    
Sbjct: 84   AQKVLEGSE--LELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGL 141

Query: 1449 ATIAELE--LEKT------------KLQELTRKLKERVTILVKQKDVLSH-------GEK 1487
                +LE  L+K             +L   + + K  +  L  QK   S        G  
Sbjct: 142  NLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSP 201

Query: 1488 EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTL 1547
               +  ++   Q     +++++   R   ++L+ E +  R  +T  + + ++   ++  L
Sbjct: 202  ASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRL 261

Query: 1548 NGSQEEMW------QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1601
                E+        ++ E ++ +N ++   +    KQ  +LK +  Q+D +  +LS++N 
Sbjct: 262  ALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG 321

Query: 1602 QNQEKLQELNQRLTEM--LCQKEKEPGNSALEEREQEKFNLKEEL------ERCKVQSST 1653
                KL+E    L ++     +  E  + A +E  +++  L++EL      ++C  + + 
Sbjct: 322  DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381

Query: 1654 L----VSSLEAELSEVKIQTHIVQQENHLLKD--ELEKMKQLHRCPDLSDFQQKISSVLS 1707
            +    +S LE  LS+  +Q +  Q++  +L D  +LE +KQ       ++ Q +    + 
Sbjct: 382  ILQGKLSQLEEHLSQ--LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML 439

Query: 1708 YNEKLLKEKEALSEELNSCVDKLAKSSL---LEHRIATMKQ-----EQKSWEH------Q 1753
              E+  +E + L+E  +   +K   SSL   L+  I+ + Q     EQ S  H      Q
Sbjct: 440  ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499

Query: 1754 SASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKE---------------A 1798
             ASL S+L      +Q  +  +  +  Q    ++ L  T Q++E               +
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559

Query: 1799 LKQEVMSLHK--QLQNAGGKSWAPEIAT----------HPSGLHNQQKRLSWDKLDHL-- 1844
            LKQ+   L +  + Q A  +  A ++AT                 Q + L  +K   L  
Sbjct: 560  LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619

Query: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
            + ++ Q+  +  +  QT V   + E      KV +L++ +    Q+       +   E +
Sbjct: 620  LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679

Query: 1905 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQV-KLDEQLMEMQHL 1963
              S +++  + ++     ++   Q+ +L++ L+      E  K++    L+EQ   +  L
Sbjct: 680  LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL 739

Query: 1964 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2023
            ++        H  + + L+++       E  LQ   +  QAE   + L+ EL    +  +
Sbjct: 740  KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAE--TEVLRRELAEAMAAQH 797

Query: 2024 TPQGNQEQL---VTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYV 2080
            T +   EQL   V    ER  + +Q+      + QE++  LKE+ C+  + +       V
Sbjct: 798  TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE-CEKARQELQEAKEKV 856

Query: 2081 ENAQLLKALEVTEQRQKTAE 2100
               +    L+++ Q+ + AE
Sbjct: 857  AGIESHSELQISRQQNELAE 876



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 99/431 (22%), Positives = 172/431 (39%), Gaps = 28/431 (6%)

Query: 1706 LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQ 1765
            L+ N KLL EK+A    +   +D+LA   LL  + A    E K  E      +S  +   
Sbjct: 237  LAENRKLLTEKDAQIAMMQQRIDRLA---LLNEKQAASPLEPKELEELRDKNESLTMRLH 293

Query: 1766 EKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATH 1825
            E ++  +D ++    QM R  + L     +     +E  S  +QLQ+A  +         
Sbjct: 294  ETLKQCQD-LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKAT 352

Query: 1826 PSGLHNQ---QKRLSWDKLDHLMNEE-----QQLLWQENERLQTMVQNTKAELTHSREKV 1877
               L  Q   +K LS    D    EE     Q  L Q  E L  +  N   E       V
Sbjct: 353  QEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV 412

Query: 1878 RQLES-----NLLPKHQKHLNPSGTMNPTE--QEKLSLKRECDQFQKEQSPANRKVSQMN 1930
             QLE+       L  +   L     M  TE  Q++  L  E   F++E+   +  ++ + 
Sbjct: 413  LQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQ 472

Query: 1931 SLEQELETIHLENEGLKKKQ-VKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMV 1989
            S    L     E E   +    +L  Q+  +    +T   +      +L  L+QQA    
Sbjct: 473  SSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQA---- 528

Query: 1990 PREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKL 2049
             +E+  QL + L Q E+ +Q L+ ++E  +S        ++QL  V E++    +   + 
Sbjct: 529  -KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ---KEQQLKEVAEKQEATRQDHAQQ 584

Query: 2050 VKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEK 2109
            +    +E+   L+E+     + +A+ K+   +   L + L+V  + + +A+      + +
Sbjct: 585  LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQRE 644

Query: 2110 IASLSNIVRNL 2120
             A LS  V  L
Sbjct: 645  KAELSRKVEEL 655



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 50/214 (23%), Positives = 88/214 (41%), Gaps = 21/214 (9%)

Query: 1913 DQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS 1972
            D  Q  Q    R   Q+       + + LE    +K   + D Q+  MQ           
Sbjct: 207  DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR------ 260

Query: 1973 PHAWDLQLL--QQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQE 2030
                 L LL  +Q A P+ P+E    L+    + E +   L E L+ +  +  T +   +
Sbjct: 261  -----LALLNEKQAASPLEPKE----LEELRDKNESLTMRLHETLK-QCQDLKTEKSQMD 310

Query: 2031 QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALE 2090
            + +  + E   ++  KL+     LQ+  + L E   +++KA    ++   + AQL K L 
Sbjct: 311  RKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKA---TQEWLEKQAQLEKELS 367

Query: 2091 VTEQRQKTAEKKNYLLEEKIASLSNIVRNLTPAP 2124
               Q +K  E+KN +L+ K++ L   +  L   P
Sbjct: 368  AALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNP 401


>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
          Length = 2479

 Score =  159 bits (401), Expect = 4e-38
 Identities = 425/2164 (19%), Positives = 833/2164 (38%), Gaps = 427/2164 (19%)

Query: 323  QEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVRE 382
            +E+ KA +        L    + LENEL + + S         + EI  L ++++Q  RE
Sbjct: 71   EEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRE 130

Query: 383  KEKLRSDLDKAEKLKSLMA---SEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRK 439
             E +  +L+K +K+   +A    E ++ ++ + R N+  L+K +E+  + I   + ++  
Sbjct: 131  LEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENK-RLKKKNEQLCQDIIDYQKQIDS 189

Query: 440  EREQILQQAG----------KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLE 489
            ++E +L + G          K+  EL Q +++ +T      +++ +  +E  +   E ++
Sbjct: 190  QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTE-ANEKIEVQNQEMRKNLEESVQ 248

Query: 490  NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQM---RNEYERQCRV 546
              EK+ +  N    +    +NV+ +    L   +  + LQ + LT +   +NE +    V
Sbjct: 249  EMEKMTDEYNRMKAIVHQTDNVIDQ----LKKENDHYQLQVQELTDLLKSKNEEDDPIMV 304

Query: 547  -LQDQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 598
             +  +V+E +        E+ EY+     LR  LKN+  +  ++N   ++        + 
Sbjct: 305  AVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQI 364

Query: 599  NPLNMSIEA--------ELVIEQMK-------------EQHHRDICCLRLELEDKVRHYE 637
              L   +E           +IE +K             +Q H  I      L++K +  E
Sbjct: 365  KMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAE 424

Query: 638  KQ-------------------------------LDETVVSCKKAQENMKQRHEN------ 660
            +                                L++ VV  K  +  +K R         
Sbjct: 425  RTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTK 484

Query: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEAT-CRHEEEKKQLQVKLEEEKTHLQEKL 719
            E + LE +ISD  +E   L+ +  +  +   + T  R+ +  KQ Q + E +    + + 
Sbjct: 485  EINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIES 544

Query: 720  RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ---FHQEQLTSLVEK 776
              +  ++LK ++ Q     ER +    S   TE+    LT+ + Q     + +L  L  K
Sbjct: 545  LEEERLDLKKKIRQMAQ--ERGKRSATSGLTTEDL--NLTENISQGDRISERKLDLLSLK 600

Query: 777  HTLE----KEELRKELLEKHQRELQEGREKMETECNR------RTSQIEAQFQSDCQKVT 826
            +  E     E L +EL+EK +R+L+  R  +    N+         Q+E   +   Q + 
Sbjct: 601  NMSEAQSKNEFLSRELIEK-ERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIK 659

Query: 827  ER-----------------CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869
            E                   E  + ++E +  + + D     + +  Q     +EL QE 
Sbjct: 660  EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL 719

Query: 870  AEA--------QELLKETLK---REKTTSLVLTQEREML--------------------- 897
             E+        Q+L K  LK    EK TSL+   E   +                     
Sbjct: 720  RESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINS 779

Query: 898  EKTYKEHLNSMVVERQQLLQDLEDLRN-------VSETQQSLLSDQILELKSSHK----- 945
            +  Y  HL   +  +++ L++LED          V   QQSLL  + L  K + K     
Sbjct: 780  QNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKT 839

Query: 946  --RELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATC-ETAD 1002
               E R+ E+ + Q     +  +  L  L+M+ D+     M K+LA EN  K T  +  +
Sbjct: 840  IKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDE-----MKKILA-ENSRKITVLQVNE 893

Query: 1003 RERAEMSTEISRLQSKIKEM--QQATSPLSMLQSGCQVIG----------------EEEV 1044
            +      T +  L+ ++++   +Q    LSM    C+ IG                ++ V
Sbjct: 894  KSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953

Query: 1045 EGDGALS------------------LLQQGEQLLEE---------------------NGD 1065
            +   +LS                  +LQ+   L++                      N +
Sbjct: 954  DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKE 1013

Query: 1066 VLLSLQRAH--EQAVKENVKMATEISRLQQR----------LQKLEPGLVMSSCLDEPAT 1113
            + ++ ++ H  EQA ++  K+  E S  + +          + K    L M    +    
Sbjct: 1014 LEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRA 1073

Query: 1114 EFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE----------DDEVRDLGSTGTSSV 1163
            E      E     L+Q   +  E  T+   L+ +            DE+ D  S   S  
Sbjct: 1074 EHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDA 1133

Query: 1164 QRQ---EVKIEESEASVEGFSELENSEETRTESWELKNQISQLQ----EQLMMLCADCDR 1216
             RQ   E++  E E  VE  S+L    +      E+ N   Q +    E L M   D   
Sbjct: 1134 DRQRILELEKNEMELKVE-VSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192

Query: 1217 ASEKKQDLL----FDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETR 1272
             S++K  +      +VS+   +   L ++   + K + +     R    L E+ + +   
Sbjct: 1193 QSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYA 1252

Query: 1273 YDEALENNKELTAEVFRLQDE------LKKMEEVTETFLSLEKSYDEVKI---------E 1317
              E     K L   +  L+ +      L + E+ ++T + L+   D++KI         E
Sbjct: 1253 RLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN--DKLKIMQEMKNSQQE 1310

Query: 1318 NEELNVLVLRLQGKIEKLQESVVQRCDC------CLWEASLENLEIEPDGNILQLNQTLE 1371
            +  +    L ++ K++ L+E +    D         W   +E L ++     L+LN+ L 
Sbjct: 1311 HRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQE----LKLNRELV 1366

Query: 1372 ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE---IAWLHGTIQTHQERPRVQNQ 1428
            +    ++ ++++I E ++    LE   +++++ K HE   +AW    +   +     Q  
Sbjct: 1367 KDKEEIKYLNNIISEYERTISSLE--EEIVQQNKFHEERQMAWDQREVDLER-----QLD 1419

Query: 1429 VILEENTTLLGFQDKHFQHQATIAELELE-KTKLQELTRKLKERVTILVKQKDVL-SHGE 1486
            +   +   +L    K  +   +I +  L    +L+   RK+KE + I+++ +    S  E
Sbjct: 1420 IFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEE 1479

Query: 1487 KEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLG- 1545
            K +E ++ +   +       + +  LR       +   ++        E  S   LK+  
Sbjct: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539

Query: 1546 -TLNGSQEEMWQKTETVKQENAAVQKMVEN----LKKQISELKIKNQQLDLENTELSQKN 1600
             T+   Q  + QK E +K+    ++K  E     +KK   +L I + +L+L+      K 
Sbjct: 1540 QTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKF 1599

Query: 1601 SQNQE-----------------KLQELNQRLTEM------LCQKEKEPGNSALEEREQEK 1637
             Q                    +L E+ Q + E       L  K K+       +RE  +
Sbjct: 1600 KQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITE 1659

Query: 1638 FNLKEELERCKVQ----SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLH-RC 1692
              +KE  E  K+Q        V  ++AE+ ++K      Q+E+  LK EL+  K+ + R 
Sbjct: 1660 LKVKE-FENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRA 1718

Query: 1693 P--DLSDFQQKISSVLSYNEK-----------LLKEKEALSEE--LNSCVDK---LAKSS 1734
            P   + +  +++ S L+  EK           L  E  A +EE  +++   K   L    
Sbjct: 1719 PTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ 1778

Query: 1735 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1794
            +++     +K + +        LK  L  S+ +  +L D + ++N ++ + +       +
Sbjct: 1779 IVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILR 1838

Query: 1795 EKEALKQEVMSLHKQLQN-AGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN------- 1846
            EKE + QE   L +Q++    G    P      S +   Q+++   KL++ +        
Sbjct: 1839 EKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK--KLENQLEGKVEEVD 1896

Query: 1847 ---------EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT 1897
                     +E+ + W+E ++ Q  ++         R K+++ E  +    ++       
Sbjct: 1897 LKPMKEKNAKEELIRWEEGKKWQAKIEGI-------RNKLKEKEGEVFTLTKQLNTLKDL 1949

Query: 1898 MNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQL 1957
                ++EKL+L+R+     K       +V  + +LE E E      E LKK+ + L+  +
Sbjct: 1950 FAKADKEKLTLQRKL----KTTGMTVDQVLGIRALESEKEL-----EELKKRNLDLENDI 2000

Query: 1958 MEMQ--------------HLRSTATPSPSPHAWDLQLLQQ----------QACPMVPREQ 1993
            + M+              HL++        HA + Q  +           ++     REQ
Sbjct: 2001 LYMRAHQALPRDSVVEDLHLQNRYL-QEKLHALEKQFSKDTYSKPSISGIESDDHCQREQ 2059

Query: 1994 FLQLQRQLLQAERINQHLQEELENR-TSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKR 2052
             LQ +   L +E I    Q E  N+          + +++   +++   EV++KL  V+ 
Sbjct: 2060 ELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRG 2119

Query: 2053 LLQ--EKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEV-TEQRQKTAEKKNYLLEEK 2109
              +  + + +L++ +    K   +V+ +  EN QL KA  + T ++    E++N  L+ +
Sbjct: 2120 SGRSGKTIPELEKTIGLMKK---VVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAE 2176

Query: 2110 IASL 2113
            +  L
Sbjct: 2177 LEKL 2180



 Score =  149 bits (376), Expect = 3e-35
 Identities = 335/1722 (19%), Positives = 702/1722 (40%), Gaps = 263/1722 (15%)

Query: 435  NELRKERE----------QILQQAGKQRLELE-QEIEKAKTEENYIRDRLALSLKENSRL 483
            NEL+ E++          Q L +   Q +EL  +E+EKA  E+    ++L   +    +L
Sbjct: 38   NELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVM---KL 94

Query: 484  ENELLENAEKLA---EYENLTNKLQRNLENVLAEKFGDLDPSSAEF----------FLQE 530
            ENEL E A++ A   +   L N++ + LE  L +K  +L+    E            L+ 
Sbjct: 95   ENEL-EMAQQSAGGRDTRFLRNEICQ-LEKQLEQKDRELEDMEKELEKEKKVNEQLALRN 152

Query: 531  ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
            E      ++  R+ + L+ + ++L  ++ +Y+ Q    +  L +   E+ +  S   +  
Sbjct: 153  EEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKN 212

Query: 591  HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
            + L  +  + +    EA   IE   ++       +R  LE+ V+  EK  DE        
Sbjct: 213  YEL-IQYLDEIQTLTEANEKIEVQNQE-------MRKNLEESVQEMEKMTDEY-----NR 259

Query: 651  QENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHE------ATCRHEEEKKQL 704
             + +  + +N    L+K+    + ++ EL     +LK  + E      A     EE K +
Sbjct: 260  MKAIVHQTDNVIDQLKKENDHYQLQVQELTD---LLKSKNEEDDPIMVAVNAKVEEWKLI 316

Query: 705  QVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ 764
                ++E    Q+ L    E    A+L   +++    ++G+Q     + +++ LT+++EQ
Sbjct: 317  LSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER---DSQIKMLTEQVEQ 373

Query: 765  FHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK 824
            + +E     +EK+T   E+L+ EL           R K  +  +++T           ++
Sbjct: 374  YTKE-----MEKNTCIIEDLKNELQ----------RNKGASTLSQQTHMKIQSTLDILKE 418

Query: 825  VTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREK 884
             T+  E   +  E   R++ K+L E  +  K   ++E      E A  +      +K  K
Sbjct: 419  KTKEAERTAELAEADAREKDKELVEALKRLK---DYESGVYGLEDAVVE------IKNCK 469

Query: 885  TTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSH 944
                +  +E E+L K     +N + ++    L + E LR     +   + D      S H
Sbjct: 470  NQIKIRDREIEILTK----EINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKH 525

Query: 945  KRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKL--LAMENIHKATCETAD 1002
             ++ + R E         Q+  + +E LE    +ER ++  K+  +A E   ++      
Sbjct: 526  LKQQQYRAE--------NQILLKEIESLE----EERLDLKKKIRQMAQERGKRSATSGLT 573

Query: 1003 RERAEMSTEISRLQSKIKEMQQ---ATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1059
             E   ++  IS+   +I E +    +   +S  QS  + +  E +E           E+ 
Sbjct: 574  TEDLNLTENISQ-GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEK----------ERD 622

Query: 1060 LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS---SCLDEPATEFF 1116
            LE +  V+   Q   ++ V+EN ++   +  + Q +++++    +    + L  P+ E  
Sbjct: 623  LERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERL 682

Query: 1117 GNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEAS 1176
             N  E          +K  EG+    +    + D++     TG +   RQE++  ES   
Sbjct: 683  VNAIE----------SKNAEGIFDASLHLKAQVDQL-----TGRNEELRQELR--ESRKE 725

Query: 1177 VEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRA-----------SEKKQDLL 1225
               +S+       + +  E +  + +  E   ++    D             + + + L+
Sbjct: 726  AINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLI 785

Query: 1226 FDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTA 1285
              +  L+ K K L+ + ++   Y   +  +  +   L          Y E L   +    
Sbjct: 786  HLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLL----------YKEYLSEKETWKT 835

Query: 1286 EVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDC 1345
            E   +++E +K+E+  +         D +K++  E N L+  LQ   +++++ + +    
Sbjct: 836  ESKTIKEEKRKLEDQVQQ--------DAIKVK--EYNNLLNALQMDSDEMKKILAEN--- 882

Query: 1346 CLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVK 1405
                  +  L++     I Q   TL E   ++R      E  KQ+N+ L    ++ EK+ 
Sbjct: 883  ---SRKITVLQVNEKSLIRQYT-TLVELERQLRK-----ENEKQKNELLSMEAEVCEKI- 932

Query: 1406 AHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELT 1465
                    G +Q  +E    +   +            K   +  +++ELEL   +  ELT
Sbjct: 933  --------GCLQRFKEMAIFKIAAL-----------QKVVDNSVSLSELELANKQYNELT 973

Query: 1466 RKLKE---RVTILVKQKDVLSHGEKE-----EELKAMMHDLQITCSEMQQKVELLRYESE 1517
             K ++   +  +LV++   L H E E     E+++++  +L+IT  ++        +  E
Sbjct: 974  AKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKL--------HTIE 1025

Query: 1518 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
            +  ++ + L NE +    + SI+N  + +++     +  K    +Q     QKM E+L+ 
Sbjct: 1026 QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRT 1085

Query: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
             + +++ +N +L+ +  EL++ N   Q+  Q L   L + + +   +     + E E+ +
Sbjct: 1086 SLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNE 1145

Query: 1638 FNLKEELERCKVQSSTLVSSLEAELSEV-KIQTHIVQQENHLLKDELEKMK-QLHRCPDL 1695
              LK E+ + +            E+S++ + Q  I+  +      E+E ++ QL      
Sbjct: 1146 MELKVEVSKLR------------EISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQ 1193

Query: 1696 SDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSA 1755
            SD +  I+ +  +N  L   +     +L S   KL K      R+     EQK  E + A
Sbjct: 1194 SDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRL-----EQKLDEKEQA 1248

Query: 1756 SLKSQLVASQEKVQNLEDTVQNVNLQMS---------RMKSDLRVTQQEKEALKQEVMSL 1806
               ++L   + + ++L  T+Q++  Q S         +    +   Q +K  + QE+ + 
Sbjct: 1249 LYYARL-EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNS 1307

Query: 1807 HKQLQNAGGKS--------WAPEIATHPSGLHNQQKRLSWD-KLDHLMNEEQQL---LWQ 1854
             ++ +N   K+           E+ +        QK ++W  K++ L  +E +L   L +
Sbjct: 1308 QQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVK 1367

Query: 1855 ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1914
            + E ++  + N  +E   +   +  LE  ++ +++ H          +Q ++ L+R+ D 
Sbjct: 1368 DKEEIK-YLNNIISEYERT---ISSLEEEIVQQNKFH---EERQMAWDQREVDLERQLDI 1420

Query: 1915 FQKEQSPANRKVSQMNSLEQEL--ETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS 1972
            F ++Q+       +       +   ++ L N+ L+    K+ E +  +   R+T      
Sbjct: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQ-LEIALRKIKENIRIILETRATCKSLEE 1479

Query: 1973 PHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQ--E 2030
                    L+     ++ R++ +   R  L A    + L  EL  +  E  +    +   
Sbjct: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539

Query: 2031 QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKAD 2072
            Q +  M+ R+ + E+ LK  +RLL EK  + + ++ K  + D
Sbjct: 1540 QTIANMQARLNQKEEVLKKYQRLL-EKAREEQREIVKKHEED 1580



 Score =  149 bits (375), Expect = 4e-35
 Identities = 301/1518 (19%), Positives = 645/1518 (42%), Gaps = 195/1518 (12%)

Query: 304  HASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALA 363
            H   E I    Q E I    EI K    +++      E  L  E+ +   K SI  + + 
Sbjct: 995  HLECENISLKEQVESINKELEITKEKLHTIEQAWE-QETKLGNESSMDKAKKSITNSDIV 1053

Query: 364  SFKAEIRHL-------LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNE 416
            S   +I  L        +R +   +  E LR+ L + E+       E++   A + + N 
Sbjct: 1054 SISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNF----ELETKFAELTKIN- 1108

Query: 417  YNLRKLDEEYKERIA--ALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 474
             + +K+++  ++ +A    K     +R++IL+   K  +EL+ E+ K +   +  R ++ 
Sbjct: 1109 LDAQKVEQMLRDELADSVSKAVSDADRQRILELE-KNEMELKVEVSKLREISDIARRQVE 1167

Query: 475  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
            +   +    + E+     +L +Y+  ++  +++L   L +    L  S A    + E +T
Sbjct: 1168 ILNAQQQSRDKEVESLRMQLLDYQAQSD--EKSLIAKLHQHNVSLQLSEATALGKLESIT 1225

Query: 535  QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG 594
                + E     L+ ++DE +  L   R +GR     L+ +  + +     G  P     
Sbjct: 1226 SKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQT-IQSLRRQFSGALPLAQQE 1284

Query: 595  SEECNPLNMSIEAELVIEQMK--EQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 652
                  + +  +   ++++MK  +Q HR++    LE+E K++  E +L  T+   K AQ+
Sbjct: 1285 KFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLE-ELISTLKDTKGAQK 1343

Query: 653  NMKQRHENETHTLEK------------QISDLKNEIAELQGQAAVLKEAHHEATCRHEEE 700
             +    + E   L++            +I  L N I+E +   + L+E   +    HEE 
Sbjct: 1344 VINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEER 1403

Query: 701  KKQLQVKLEEEKTHLQEKL----RLQHEMELKARL----------------TQAQASFER 740
                Q+  ++ +  L+ +L    R Q+E+   A+                  Q + +  +
Sbjct: 1404 ----QMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRK 1459

Query: 741  EREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL-------LEKHQ 793
             +E ++    T    + L ++L++  +E    L E++ L ++++  EL        E+ +
Sbjct: 1460 IKENIRIILETRATCKSLEEKLKE--KESALRLAEQNILSRDKVINELRLRLPATAEREK 1517

Query: 794  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 853
               + GR++ME + +  T +I  Q  ++ Q    + E  L+    +Y++ L+  +E+QRE
Sbjct: 1518 LIAELGRKEMEPK-SHHTLKIAHQTIANMQARLNQKEEVLK----KYQRLLEKAREEQRE 1572

Query: 854  EKSQWEFE------------KDELTQECAEAQELLKETLKREKTTS-LVLTQEREMLEKT 900
               + E +               L +    A +L+K++     T    +   E E     
Sbjct: 1573 IVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAE 1632

Query: 901  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSH-------KRELREREE 953
              + L+S++V+ +++ QDLE  R ++E +     +  L+L+ +H       K E+ + + 
Sbjct: 1633 QDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKY 1692

Query: 954  VLCQAGASEQLASQRLERLEMEHDQER--------QEMMSKLLAMENIHKATCETADRER 1005
            +L Q+    Q     L+  +  + +          + + S+L   E   KA        R
Sbjct: 1693 LLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELR 1752

Query: 1006 AEMS--------TEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGE 1057
            AEM+        +  S+ ++ +   Q        L++  + + E  ++   AL   +  E
Sbjct: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRE 1812

Query: 1058 QLLEEN----GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPAT 1113
              L +N     + L   Q+A+ + ++E  ++  E   L++++++L  GL       +P T
Sbjct: 1813 NSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQ-----GKPLT 1867

Query: 1114 EFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDL------GSTGTSSVQRQE 1167
            +   +  E+ +  +++    Q+EG      L  +++   ++       G    + ++   
Sbjct: 1868 DNKQSLIEELQRKVKKLEN-QLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIR 1926

Query: 1168 VKIEESEASVEGFSELENS---------EETRTESWELKNQISQLQEQLMMLCADCDRAS 1218
             K++E E  V   ++  N+         +E  T   +LK     + + L +   + ++  
Sbjct: 1927 NKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKEL 1986

Query: 1219 E--KKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEA 1276
            E  KK++L  +  +L        R  +A P+  ++ ED+  +N  LQE+L  +E ++ + 
Sbjct: 1987 EELKKRNLDLENDILYM------RAHQALPRDSVV-EDLHLQNRYLQEKLHALEKQFSKD 2039

Query: 1277 LENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQ 1336
              +   ++       D  ++ +E+ +  L L     E+K + E+ N  + RL+ ++  L+
Sbjct: 2040 TYSKPSISG--IESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLK 2097

Query: 1337 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYL-- 1394
            E     C+    E +    ++       +  +T+ E    +  +  V+E+ ++EN+ L  
Sbjct: 2098 EM----CEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKK 2153

Query: 1395 --------------EGNTQL---LEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1437
                          + N +L   LEK+KAH    L   +  H E      + I+ EN  L
Sbjct: 2154 ASGILTSEKMANIEQENEKLKAELEKLKAH----LGHQLSMHYESKTKGTEKIIAENERL 2209

Query: 1438 LGFQDKHFQHQATIAE-LELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMH 1496
                 K  + +   AE L + K  L+ L     E++T+ +++      G++ +  ++   
Sbjct: 2210 R----KELKKETDAAEKLRIAKNNLEILN----EKMTVQLEET-----GKRLQFAESRGP 2256

Query: 1497 DLQITCSEMQQKVELLR-YESEKLQQENSILRNE--ITTLNEEDSISNLKLGTLNGSQEE 1553
             L+   S+  + + + R YE++  + E  I +    IT L +    +  +   +N   E+
Sbjct: 2257 QLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNED 2316

Query: 1554 MWQKTETVKQ--ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKL-QEL 1610
            + Q+ + +K   E A  +   + LK+++  L++ N QLD E  EL  +   N+++   E 
Sbjct: 2317 LEQQIKILKHVPEGAETE---QGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAES 2373

Query: 1611 NQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTH 1670
                 + L +K K+   + L+  + EK +LKEE+++ K +      S   E+ ++K    
Sbjct: 2374 TIPDADQLKEKIKDL-ETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYK 2432

Query: 1671 IVQQENHLLKDELEKMKQ 1688
               ++N LL+++++K+ +
Sbjct: 2433 EEVKKNILLEEKVKKLSE 2450



 Score =  142 bits (357), Expect = 5e-33
 Identities = 372/1924 (19%), Positives = 774/1924 (40%), Gaps = 298/1924 (15%)

Query: 320  ENSQEILKAL-DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQ 378
            E  +EIL+A+ +   D ++   E +L + +   +      + A   F A + HL  +VDQ
Sbjct: 649  EGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASL-HLKAQVDQ 707

Query: 379  VVREKEKLRSDL---------------------DKAEKLKSLMASEVDDH---------- 407
            +    E+LR +L                     D  EK  SL+      +          
Sbjct: 708  LTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPD 767

Query: 408  ------HAAIERRNEYNLRKLDE-EYKER-IAALKNELRKEREQILQQAGKQRL---ELE 456
                   + I  +NEY +  L E E KE+ +  L++ L     +      +Q L   E  
Sbjct: 768  GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYL 827

Query: 457  QEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRN---LENVLA 513
             E E  KTE   I++       E  +LE+++ ++A K+ EY NL N LQ +   ++ +LA
Sbjct: 828  SEKETWKTESKTIKE-------EKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILA 880

Query: 514  E---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL-EEYRAQGRVLR 569
            E   K   L  +      Q   L ++  +  ++    ++++  +++E+ E+     R   
Sbjct: 881  ENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKE 940

Query: 570  LPL-KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDIC---CL 625
            + + K +  ++V  NS  +  E  L +++ N L       L  + M  Q   ++    C 
Sbjct: 941  MAIFKIAALQKVVDNSVSLS-ELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECE 999

Query: 626  RLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 685
             + L+++V    K+L+ T    K+    ++Q  E ET         L NE +  + + ++
Sbjct: 1000 NISLKEQVESINKELEIT----KEKLHTIEQAWEQETK--------LGNESSMDKAKKSI 1047

Query: 686  LKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGL 745
                    +      KK   ++++E    L E+ R +H  ++   L  +    E     L
Sbjct: 1048 TNSDIVSIS------KKITMLEMKE----LNERQRAEHCQKMYEHLRTSLKQMEERNFEL 1097

Query: 746  QSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMET 805
            ++      K+    Q++EQ  +++L   V K   + +  R   LEK++ EL+    K+  
Sbjct: 1098 ETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLRE 1157

Query: 806  ECNRRTSQIE---AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEK 862
              +    Q+E   AQ QS  ++V        +SL    R +L D Q Q  E+    +  +
Sbjct: 1158 ISDIARRQVEILNAQQQSRDKEV--------ESL----RMQLLDYQAQSDEKSLIAKLHQ 1205

Query: 863  DELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQ--DLE 920
              ++ + +EA  L K     E  TS +   E       Y   L   + E++Q L    LE
Sbjct: 1206 HNVSLQLSEATALGK----LESITSKLQKME------AYNLRLEQKLDEKEQALYYARLE 1255

Query: 921  DLRNVSETQQSLLSDQILELKSSHKRELREREE---VLCQAGASEQLASQRLERLEMEHD 977
                    +Q++   Q L  + S    L ++E+    + Q    +    Q ++  + EH 
Sbjct: 1256 GRNRAKHLRQTI---QSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHR 1312

Query: 978  QERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQ 1037
                + +   L ++ + +      D + A+   ++     KI+E++     L  L+   +
Sbjct: 1313 NMENKTLEMELKLKGLEELISTLKDTKGAQ---KVINWHMKIEELR-----LQELKLNRE 1364

Query: 1038 VIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK 1097
            ++ ++E E     +++ + E+ +    + ++   + HE+      +   ++ R      +
Sbjct: 1365 LVKDKE-EIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDR 1423

Query: 1098 LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGS 1157
             +  ++ ++   E AT   G+  + + P        Q+E   R+        + +R +  
Sbjct: 1424 QQNEILNAAQKFEEAT---GSIPDPSLPL-----PNQLEIALRKI------KENIRIILE 1469

Query: 1158 TGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRA 1217
            T  +    +E K++E E+++    +   S +       L+   +  +E+L+      +  
Sbjct: 1470 TRATCKSLEE-KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEME 1528

Query: 1218 SEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL----QEELRMMETRY 1273
             +    L      +      L +  E   KY+ L E    E   +    +E+L ++  R 
Sbjct: 1529 PKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRL 1588

Query: 1274 D-EALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKI 1332
            + +A  +  +     + L  +        + F+ L +    V  +++ L+ L+++L+   
Sbjct: 1589 ELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVS 1648

Query: 1333 EKLQESVVQRCDCCLWEASLENLEIEPDGNI-LQLNQTLEECVPRVRS----VHHVIEEC 1387
            + L+            +  +  L+++   NI LQL +  E+ V +V++    + +++++ 
Sbjct: 1649 QDLER-----------QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQS 1697

Query: 1388 KQENQYLEGNTQLLEKVKAHE--------IAWLHGTIQTHQERPRVQNQVILEENTTLLG 1439
            ++E+Q L+   Q  ++  +          +  L   +   +++ +  ++ +LE    +  
Sbjct: 1698 QKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTA 1757

Query: 1440 FQDKHFQHQATIAELELEKTKLQEL-TRKLKERVTIL----VKQKDVLSHGE-KEEELKA 1493
              ++      +  E  L   ++ +  TR+LK +V  L    +K K+ L   + +E  L  
Sbjct: 1758 AAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTD 1817

Query: 1494 MMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL-----------NEEDSISNL 1542
             ++DL     + Q+    +  E E++ QEN  L+ +I  L           N++  I  L
Sbjct: 1818 NLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEEL 1877

Query: 1543 KL------GTLNGSQEEM----------------------WQ-KTETVKQENAAVQKMVE 1573
            +         L G  EE+                      WQ K E ++ +    +  V 
Sbjct: 1878 QRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVF 1937

Query: 1574 NLKKQISELKIKNQQLDLENTELSQKNS---------------QNQEKLQELNQRLTEM- 1617
             L KQ++ LK    + D E   L +K                 +++++L+EL +R  ++ 
Sbjct: 1938 TLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLE 1997

Query: 1618 -----LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHI- 1671
                 +   +  P +S +E+   +   L+E+L   + Q S    S +  +S ++   H  
Sbjct: 1998 NDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYS-KPSISGIESDDHCQ 2056

Query: 1672 ----VQQENHLLKDELEKMK-QLHRC-PDLSDFQQKISSVLSYNEKLLKEKEALSEELNS 1725
                +Q+EN  L  E  ++K QL +   DL   + ++  +    E L KEK  +  +L  
Sbjct: 2057 REQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGH 2116

Query: 1726 CVDKLAKSSL---LEHRIATMKQEQKSWEHQSASLKSQL-VASQEKVQNLEDTVQNVNLQ 1781
                         LE  I  MK+  +  + ++  LK    + + EK+ N+E   + +  +
Sbjct: 2117 VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAE 2176

Query: 1782 MSRMKSDL--------RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQ 1833
            + ++K+ L            +  E +  E   L K+L+     +    IA +   + N++
Sbjct: 2177 LEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEK 2236

Query: 1834 KRLSWD----KLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1889
              +  +    +L    +   QL   +++  +++V     E      K+++LE+++  K+Q
Sbjct: 2237 MTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYET-----KLKELETDIAKKNQ 2291

Query: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNS-LEQELETIHLENEGLKK 1948
                                 +  Q  KE +   +KV++ N  LEQ+++ +    EG + 
Sbjct: 2292 SIT------------------DLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAET 2333

Query: 1949 KQ-VKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVP-----REQFLQLQRQLL 2002
            +Q +K + Q++ + + +     +   H  +    Q  A   +P     +E+   L+ QL 
Sbjct: 2334 EQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLK 2393

Query: 2003 QAERINQHLQEELENRTSET-NTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQL 2061
             ++   QHL+EE++    E  N      E++  +      EV++ +     LL+EKV +L
Sbjct: 2394 MSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNI-----LLEEKVKKL 2448

Query: 2062 KEQL 2065
             EQL
Sbjct: 2449 SEQL 2452



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 226/1145 (19%), Positives = 463/1145 (40%), Gaps = 218/1145 (19%)

Query: 307  VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 366
            +ER LD +  +      EIL A     +   ++ + +L L N+L        + AL   K
Sbjct: 1414 LERQLDIFDRQ----QNEILNAAQKFEEATGSIPDPSLPLPNQL--------EIALRKIK 1461

Query: 367  AEIRHLLER------VDQVVREKE------------------KLRSDLDKAEKLKSLMAS 402
              IR +LE       +++ ++EKE                  +LR  L    + + L+A 
Sbjct: 1462 ENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIA- 1520

Query: 403  EVDDHHAAIERRNEYNLRKLDEEYKERIAAL--KNELRKEREQILQQAGKQRLELEQEIE 460
              +     +E ++ + L+   +      A L  K E+ K+ +++L++A +++ E+   ++
Sbjct: 1521 --ELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREI---VK 1575

Query: 461  KAKTEENYIRDRLAL----SLKENSRLENELLENAE----------KLAEYENLTNKLQR 506
            K + + + +  RL L    SL +  +   +L++ +           +LAE E    +   
Sbjct: 1576 KHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDD 1635

Query: 507  NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ----DQVDELQSELEEYR 562
            +L ++L +    L   S +   Q E       E+E     LQ    D+V ++++E+E+ +
Sbjct: 1636 SLSSLLVK----LKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLK 1691

Query: 563  A---QGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHH 619
                Q +     LK+    + EANS          +     L   ++++L +   KE+  
Sbjct: 1692 YLLDQSQKESQCLKSELQAQKEANSRA-------PTTTMRNLVERLKSQLAL---KEKQQ 1741

Query: 620  RDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAEL 679
            + +    LEL  ++    ++   +  S K+A  N++Q  +  T  L+ Q+ DL   + +L
Sbjct: 1742 KALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKL 1801

Query: 680  QGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFE 739
            +      K   +  T    +   +LQ K +     L+EK  +  E +      + +   +
Sbjct: 1802 KEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEND------ELKRQIK 1855

Query: 740  REREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG 799
            R   GLQ    T+ K                 SL+E                   ELQ  
Sbjct: 1856 RLTSGLQGKPLTDNK----------------QSLIE-------------------ELQRK 1880

Query: 800  REKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG-RYRQELKDLQEQQREEKSQW 858
             +K+E +   +  +++ +      K     E  ++  EG +++ +++ ++ + +E+    
Sbjct: 1881 VKKLENQLEGKVEEVDLK----PMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEK---- 1932

Query: 859  EFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQD 918
            E E   LT++       LK+   +     L L ++ +    T  + L    +E ++ L++
Sbjct: 1933 EGEVFTLTKQL----NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEE 1988

Query: 919  LE----DLRN---VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER 971
            L+    DL N        Q+L  D ++E      R L+E+   L +  + +  +   +  
Sbjct: 1989 LKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISG 2048

Query: 972  LEM-EHDQERQEMMSK--LLAMENIH----------------------KATCETADRERA 1006
            +E  +H Q  QE+  +   L+ ENI                       K  CE   +E+A
Sbjct: 2049 IESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKA 2108

Query: 1007 EMSTEISRLQSK------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL------SLLQ 1054
            E+  ++  ++        I E+++    +  +    Q   E+  +  G L      ++ Q
Sbjct: 2109 EVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQ 2168

Query: 1055 QGEQLLEE----NGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDE 1110
            + E+L  E       +   L   +E   K   K+  E  RL++ L+K           + 
Sbjct: 2169 ENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK-----------ET 2217

Query: 1111 PATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV---QRQE 1167
             A E     A+     L +  T Q+E   +R   ++    ++    S    S+   +  E
Sbjct: 2218 DAAEKL-RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE 2276

Query: 1168 VKIEESEASV----EGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQD 1223
             K++E E  +    +  ++L+   +  TE  +  N+ ++  EQ + +       +E +Q 
Sbjct: 2277 TKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQG 2336

Query: 1224 LLFDVSVL--------KKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
            L  ++ VL        K+K +++ +I EA+ K +   E    + D L+E+++ +ET+   
Sbjct: 2337 LKRELQVLRLANHQLDKEKAELIHQI-EAN-KDQSGAESTIPDADQLKEKIKDLETQL-- 2392

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETF-LSLEKSYDEVKIENEELNVLVLRLQGKIEK 1334
                 K    E   L++E+KK+++  E F  S  +  +++K   +E     + L+ K++K
Sbjct: 2393 -----KMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKK 2447

Query: 1335 LQESV 1339
            L E +
Sbjct: 2448 LSEQL 2452


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  157 bits (396), Expect = 1e-37
 Identities = 226/1143 (19%), Positives = 502/1143 (43%), Gaps = 120/1143 (10%)

Query: 754  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
            KV+ L Q   Q  + Q     ++  L+K + R++  E   +EL++   ++  E N    Q
Sbjct: 840  KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 814  IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 871
            ++A+ +  ++ +++  R  +  Q LE     E++   E++ +   Q + E+ ++ Q+  +
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954

Query: 872  AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 924
             +E L+E       L+ EK T+    ++ E       +  N +  ER+ L + + DL  N
Sbjct: 955  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014

Query: 925  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 984
            ++E ++   +  + +LK+ H+  + E E  L      E+ + Q LE+L+ + + +  +  
Sbjct: 1015 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 985  SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1043
             ++  ++  I +   + A +E  E+   ++RL  +I +   A   +  L+     I + +
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1124

Query: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
             + D   +   + E+   + G+ L +L+   E  +          ++ + R ++ +   V
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1178

Query: 1104 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1156
            +   LDE          E  +   Q  +  T+Q+E   R     D     LE +     G
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238

Query: 1157 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1213
                    +QEV  K ++ EA V+   S+  + E  R    EL +++ +LQ ++  +   
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1295

Query: 1214 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1273
             + A  K   L  DV+ L  +L+  + + +   + KL   +VS +   L+EE   ++ + 
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1352

Query: 1274 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1326
            DE +E  + L   +     +L D  KK+++   T  +LE+     + E E L        
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412

Query: 1327 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1384
                K+EK +  + Q  D  +    L+N + +   N+ +  +  ++ +   +++   +  
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 1385 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1443
            E  + E +  E  T+ L   +A E A     ++  +E  R  N+++  E   L+  +D  
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1523

Query: 1444 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1484
                       +A   ++E  KT+L+EL      T   K R+ + ++      ++D+ + 
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583

Query: 1485 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1538
             E+ EE    L+  +H+ +    + +++  L     +KL+ +  +  L+ +      E++
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643

Query: 1539 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1586
            I  L+            L     S++E++   +  +++  +++  +  L++ ++  +   
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703

Query: 1587 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1643
            +Q DLE  EL+++   +   +  LQ+  +RL   + Q E+E     LEE +     + + 
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1758

Query: 1644 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1697
            + +   Q+  L + L  E S  +      QQ   +N  L+ +L +M+   +      ++ 
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1757
             + KI+ +    E+  +EK+A ++ L    DK  K  LL+  +   ++  + ++ Q+   
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1875

Query: 1758 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1817
             +++   + +++  E+  Q +N    +++ +L    +  EA+ +EV +L  +L+     S
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935

Query: 1818 WAP 1820
            + P
Sbjct: 1936 FVP 1938



 Score =  149 bits (377), Expect = 2e-35
 Identities = 252/1230 (20%), Positives = 513/1230 (41%), Gaps = 166/1230 (13%)

Query: 427  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
            +E + A ++EL+K +E+  Q+A  +  ELEQ+  +   E+N ++++L    +  +  E  
Sbjct: 851  EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909

Query: 487  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 546
             +  A K  E E + ++++  LE                   +E+R  Q++ E ++  + 
Sbjct: 910  RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 951

Query: 547  LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 606
            + D    L+ +LEE  A  + L+L    +     EA    +E E  +  ++ N L+    
Sbjct: 952  MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1000

Query: 607  AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 653
                  ++ E+   D+     E E+K ++       +E  + E  V  KK +      E 
Sbjct: 1001 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055

Query: 654  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 713
            +K++ E +     +QI+DL+ +IAEL+ Q A  +E    A  R ++E  Q        K 
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1107

Query: 714  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 773
            +  +K+R     EL+  ++  Q   + ER     +   E++ R L +ELE    E     
Sbjct: 1108 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1155

Query: 774  VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 833
              + TL+    ++EL  K ++E+   ++ ++ E     +Q++   Q   Q V E  E   
Sbjct: 1156 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1212

Query: 834  QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
                    ++ K  +    + K   E E  +L  E     +  +E   ++K       Q 
Sbjct: 1213 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1261

Query: 894  REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 948
            +E+  K       +  LN  V + Q  ++ +  + N +E +   L+  +  L S    +L
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1317

Query: 949  REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1008
            ++ +E+L +    +   S +L +LE E +  + ++  ++ A +N+ +            +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1366

Query: 1009 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
            ST   +L    K++Q   S +  L+ G +   ++E+E     +L QQ     EE      
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1416

Query: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1128
             L++   +  +E   +  ++   +Q +  LE        L           A++ +    
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476

Query: 1129 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1187
            + R K+ + ++    L + LE  E  +L  T        E  +   +   +   ELE S+
Sbjct: 1477 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534

Query: 1188 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1238
                T+  E+K Q+ +L+++L       L  + +  + K Q   DL       ++K + L
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594

Query: 1239 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1291
            +R      +Y+   ED  ++          L+ +L+ +E + D A++  +E   ++ +LQ
Sbjct: 1595 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651

Query: 1292 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1351
             ++K  +   E       S DE+    +E       L+  + +LQE +    +    +A 
Sbjct: 1652 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1707

Query: 1352 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1405
            LE  E+ E   + L     L++   R+ + +  + EE ++E   +E  +  + K      
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767

Query: 1406 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1460
              ++E+A    T Q ++   ++   QN+ +  +   + G     F  ++TIA LE +  +
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1825

Query: 1461 LQELTR---KLKERVTILVKQKD-----VLSHGEKE----EELKAMMHDLQITCSEMQQK 1508
            L+E      + K+  T  +KQKD     +L   E E    E+ K           +++++
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885

Query: 1509 VELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAV 1568
            +E    ES+++      L+ E+    E +     ++  L  S+     +T  V    +  
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK-SKLRRGNETSFVPSRRSGG 1944

Query: 1569 QKMVENLKKQISELKIKNQQLDLENTELSQ 1598
            ++++EN     SE +   +  D   T+ S+
Sbjct: 1945 RRVIENADG--SEEETDTRDADFNGTKASE 1972



 Score =  148 bits (374), Expect = 5e-35
 Identities = 253/1137 (22%), Positives = 493/1137 (43%), Gaps = 201/1137 (17%)

Query: 345  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 404
            A E+EL  TK    +A     + E++ L ++  Q+  EK  L+  L    +L +  A E+
Sbjct: 856  AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 909

Query: 405  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 453
                AA ++  E  L +++   EE ++R   L+ E +K  +Q+L        ++A +Q+L
Sbjct: 910  RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969

Query: 454  ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 502
            +LE+   +AK ++  + D + +   +N++L  E +LLE          AE+  + +NLT 
Sbjct: 970  QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1026

Query: 503  KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 558
            KL+   E++++E   +    + S  E    + +L    +++  Q   LQ Q+ EL+ +L 
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 559  -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 598
             +E   Q  + RL      KN+  +++    G I + +  L SE                
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 599  ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 652
                    L  ++++    ++++ +  +++  L+  L+++ R +E Q+ E      +A E
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206

Query: 653  NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
             + ++ E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1262

Query: 710  E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 747
            E           +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q 
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322

Query: 748  SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
                E + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 807  CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 851
                 S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 852  RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 889
            R+     EK Q +F++             DE  +  AEA+E  KET    L R    +L 
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1497

Query: 890  LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 946
              +E E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1553

Query: 947  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1006
            EL+  E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613

Query: 1007 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1066
              +    +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D 
Sbjct: 1614 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1657

Query: 1067 LLSLQRAHEQ------AVKENVKMA----TEISRLQQRLQKLE-----PGLVMSSCLDEP 1111
               L+ A           KEN K A     ++ +LQ+ L   E       L      +E 
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717

Query: 1112 ATEFFGNTAEQTEPFLQQNRTKQ-----------VEGVTRRHVLSDLEDDEVRDLGSTGT 1160
            A+   G  A Q E    + R  Q           +E ++ R   +  + +++ +  +T  
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777

Query: 1161 SSVQRQEVKIEESEASVE----GFSELENSEETRTESW--ELKNQISQLQEQLMMLCADC 1214
            S+ Q+ E   ++ E   +       E+E + +++ +S    L+ +I+QL+EQ+     + 
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837

Query: 1215 DRAS----EKKQDLLFDVSVLKKKLKMLERIPEASPK-------YKLLYEDVSRENDCLQ 1263
              A+    +K + L   +  ++ + KM E+  E + K        K   E+   E+  + 
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897

Query: 1264 EELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
               R ++   DEA E+N+ +  EV  L+ +L++  E   +F+   +S     IEN +
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET--SFVPSRRSGGRRVIENAD 1952



 Score =  139 bits (351), Expect = 2e-32
 Identities = 242/1182 (20%), Positives = 493/1182 (41%), Gaps = 146/1182 (12%)

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 613
            LQ   +E   Q +   L       ++ E     +E +H   +EE N L   ++AE  +  
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 614  MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 673
              E+    +   + ELE+ +   E +L+E        +E+  Q+ + E   + +Q+ DL+
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 956

Query: 674  NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 733
             ++ E +     L+     A  + ++ + ++ V ++++   L ++ +L     L+ R++ 
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1010

Query: 734  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 793
               +   E          EEK + LT +L+  H+  ++ L  +  L+KEE  ++ LEK +
Sbjct: 1011 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1057

Query: 794  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 853
            R+L+        +     +QI A+ +    K  E  ++AL  L+    Q+   L++ +  
Sbjct: 1058 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1116

Query: 854  EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 911
            E    + ++D  ++  A  +    E  KR+      L +E E L+   ++ L+S   +  
Sbjct: 1117 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1167

Query: 912  -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 970
             R +  Q++  L+   + +      Q+ E++  H + + E  E L Q   ++    +  +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227

Query: 971  RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1017
             LE E+              QE +    KL A     ++ C   +R RAE++ ++ +LQ+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287

Query: 1018 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1062
            +               IK  +   S  S LQ   +++ EE  +     + L+Q E+  E 
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1345

Query: 1063 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
            N    L  Q   E   K+N++  ++T   +L    +KL+        L+E    F     
Sbjct: 1346 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402

Query: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1178
              T+ + ++         T+  +  +L DD V DL +     S++++++ K ++  A  +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461

Query: 1179 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1238
              S     E  R E+     +  + + + + L    + A E K++L     +LK +++ L
Sbjct: 1462 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 1239 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1298
                  S K     +DV +    L++  R +ET+ +E     +EL  E+   +D   ++E
Sbjct: 1517 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 1299 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1352
               +      E+       +NEE    + R   + E +L++   QR          E  L
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 1353 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1412
            ++LE++ D  I    +  EE + ++R +   +++ ++E          LE  +A     +
Sbjct: 1627 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1671

Query: 1413 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1471
              T + ++++ +            L+  Q+     +    + +LEK +L +EL   L  R
Sbjct: 1672 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724

Query: 1472 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1531
              +           +++  L+A +  L+    E Q  +E +     K  Q+   L NE+ 
Sbjct: 1725 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774

Query: 1532 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1591
            T       +      L    +E+  K    + E A   K     K  I+ L+ K  QL+ 
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1828

Query: 1592 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1646
            +  + +++     + L++ +++L E+L Q E E   +   + + EK N     LK +LE 
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888

Query: 1647 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDELEK 1685
             + +S  + ++   L+ EL E       + +E + LK +L +
Sbjct: 1889 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930



 Score =  115 bits (287), Expect = 6e-25
 Identities = 233/1157 (20%), Positives = 474/1157 (40%), Gaps = 150/1157 (12%)

Query: 1014 RLQSKIKEMQQATSPLSMLQSG---CQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSL 1070
            RL +K+K + Q T     +Q+     Q   E + + +  L  L+Q    L E  ++L   
Sbjct: 836  RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 1071 QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1130
             +A  +   E  +M   ++  +Q L+++     M + L+E                 +++
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELEEILHE--MEARLEE-----------------EED 936

Query: 1131 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1190
            R +Q++   ++     L+ +E  +        +Q ++V  E     +E    + + +  +
Sbjct: 937  RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 996

Query: 1191 TESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1250
                 L  +   L+E++  L  +     EK ++L         KLK       +  + +L
Sbjct: 997  -----LSKERKLLEERISDLTTNLAEEEEKAKNLT--------KLKNKHESMISELEVRL 1043

Query: 1251 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1310
              E+ SR+   L++  R +E    +  E   +L A++  L+ +L K EE  E   +L + 
Sbjct: 1044 KKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE--ELQAALARL 1099

Query: 1311 YDEVKIENEELNVLVLRLQGKIEKLQESV-VQRCDCCLWEASLENLEIEPDGNILQLNQT 1369
             DE+  +N  L   +  L+G I  LQE +  +R      E    +L  E +    +L  T
Sbjct: 1100 DDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158

Query: 1370 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV 1429
            L+    +           K+E +       L E+ ++HE            +  R ++  
Sbjct: 1159 LDSTATQQEL------RAKREQEVTVLKKALDEETRSHE---------AQVQEMRQKHAQ 1203

Query: 1430 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1489
             +EE T  L       Q +   A L+  K  L++    L   + +L + K  + H  K++
Sbjct: 1204 AVEELTEQLE------QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH--KKK 1255

Query: 1490 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQE--------NSILRNEITTLNEEDSISN 1541
            +L+A + +LQ  CS+ ++    L  +  KLQ E        N      I    +  S+S+
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 1542 LKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1601
                T    QEE  QK   V  +   +++   +L+ Q+ E     Q L+   + L+ + S
Sbjct: 1316 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374

Query: 1602 QNQEKLQELN-------------QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCK 1648
             +++KLQ+               Q+  E L Q+ +E   +A ++ E+ K  L++EL+   
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQELDDLV 1433

Query: 1649 VQSST---LVSSLEAELSEVKIQTHIVQQENHLLK--DELEKMKQLHRCPDLS--DFQQK 1701
            V       LVS+LE +  + K    + +++N   K  DE ++ +   R  +       + 
Sbjct: 1434 VDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491

Query: 1702 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1761
            +   L   E+L +  + L  E+    D ++    +   +  +++ +++ E Q   +K+QL
Sbjct: 1492 LEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548

Query: 1762 VASQEKVQNLEDTVQNVNLQMSRMKS----DLRVTQQEKEALKQEVM-SLHK-QLQNAGG 1815
               ++++Q  ED    + + M  +K     DL+   ++ E  ++++   LH+ + +    
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608

Query: 1816 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1875
            +      A     L    K L       +   E+ +  ++  +LQ  +++ + EL  +R 
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARA 1666

Query: 1876 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMN----S 1931
               ++                T    E++  SL+ +  Q Q++ + A R   Q +     
Sbjct: 1667 SRDEI--------------FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712

Query: 1932 LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1991
            L +EL +       L+ ++ +L+ ++ +++               +L+  Q     M  R
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEE--------------ELEEEQGNMEAMSDR 1758

Query: 1992 EQFLQLQRQLLQAERINQHLQEE----LENRTSETNTPQGNQEQLVTVMEERMIEVEQKL 2047
                 +++   QAE+++  L  E     +N ++     + N+E L + + E    V+ K 
Sbjct: 1759 -----VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE-LRSKLHEMEGAVKSKF 1812

Query: 2048 KLVKRLLQEKVNQLKEQLCKNTK-ADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLL 2106
            K     L+ K+ QL+EQ+ +  +   A  K L  ++ +L + L   E  +K AE+     
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872

Query: 2107 EEKIASLSNIVRNLTPA 2123
            E+  A +  + R L  A
Sbjct: 1873 EKGNARVKQLKRQLEEA 1889



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 57/277 (20%), Positives = 111/277 (40%), Gaps = 39/277 (14%)

Query: 323  QEILKALDFSLDGNINLTELTLALENELLVTKNSIH--QAALASFKAEIRHLLERVDQVV 380
            +E+ + L  SL G   L +    LE  +   +  +   Q  + +    +R   ++ +Q+ 
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770

Query: 381  REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE-------EYKERIAAL 433
             E    RS   K E  +             +ER+N+    KL E       ++K  IAAL
Sbjct: 1771 NELATERSTAQKNESARQ-----------QLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 434  KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 493
            + ++ +  EQ+ Q+A +     +Q   K+  +++     + L +++  ++  +  E AEK
Sbjct: 1820 EAKIAQLEEQVEQEARE-----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874

Query: 494  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 553
                     +L+R LE        + +  S        +L +  +E       +  +V+ 
Sbjct: 1875 ---GNARVKQLKRQLE--------EAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
            L+S+L   R       +P + S    V  N+ G E E
Sbjct: 1924 LKSKL---RRGNETSFVPSRRSGGRRVIENADGSEEE 1957


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  157 bits (396), Expect = 1e-37
 Identities = 226/1143 (19%), Positives = 502/1143 (43%), Gaps = 120/1143 (10%)

Query: 754  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
            KV+ L Q   Q  + Q     ++  L+K + R++  E   +EL++   ++  E N    Q
Sbjct: 847  KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 814  IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 871
            ++A+ +  ++ +++  R  +  Q LE     E++   E++ +   Q + E+ ++ Q+  +
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961

Query: 872  AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 924
             +E L+E       L+ EK T+    ++ E       +  N +  ER+ L + + DL  N
Sbjct: 962  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021

Query: 925  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 984
            ++E ++   +  + +LK+ H+  + E E  L      E+ + Q LE+L+ + + +  +  
Sbjct: 1022 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 985  SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1043
             ++  ++  I +   + A +E  E+   ++RL  +I +   A   +  L+     I + +
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1131

Query: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
             + D   +   + E+   + G+ L +L+   E  +          ++ + R ++ +   V
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1185

Query: 1104 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1156
            +   LDE          E  +   Q  +  T+Q+E   R     D     LE +     G
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245

Query: 1157 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1213
                    +QEV  K ++ EA V+   S+  + E  R    EL +++ +LQ ++  +   
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1302

Query: 1214 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1273
             + A  K   L  DV+ L  +L+  + + +   + KL   +VS +   L+EE   ++ + 
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1359

Query: 1274 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1326
            DE +E  + L   +     +L D  KK+++   T  +LE+     + E E L        
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419

Query: 1327 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1384
                K+EK +  + Q  D  +    L+N + +   N+ +  +  ++ +   +++   +  
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 1385 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1443
            E  + E +  E  T+ L   +A E A     ++  +E  R  N+++  E   L+  +D  
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1530

Query: 1444 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1484
                       +A   ++E  KT+L+EL      T   K R+ + ++      ++D+ + 
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590

Query: 1485 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1538
             E+ EE    L+  +H+ +    + +++  L     +KL+ +  +  L+ +      E++
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 1539 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1586
            I  L+            L     S++E++   +  +++  +++  +  L++ ++  +   
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710

Query: 1587 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1643
            +Q DLE  EL+++   +   +  LQ+  +RL   + Q E+E     LEE +     + + 
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1765

Query: 1644 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1697
            + +   Q+  L + L  E S  +      QQ   +N  L+ +L +M+   +      ++ 
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 1698 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1757
             + KI+ +    E+  +EK+A ++ L    DK  K  LL+  +   ++  + ++ Q+   
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1882

Query: 1758 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1817
             +++   + +++  E+  Q +N    +++ +L    +  EA+ +EV +L  +L+     S
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942

Query: 1818 WAP 1820
            + P
Sbjct: 1943 FVP 1945



 Score =  149 bits (377), Expect = 2e-35
 Identities = 252/1230 (20%), Positives = 513/1230 (41%), Gaps = 166/1230 (13%)

Query: 427  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
            +E + A ++EL+K +E+  Q+A  +  ELEQ+  +   E+N ++++L    +  +  E  
Sbjct: 858  EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916

Query: 487  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 546
             +  A K  E E + ++++  LE                   +E+R  Q++ E ++  + 
Sbjct: 917  RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 958

Query: 547  LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 606
            + D    L+ +LEE  A  + L+L    +     EA    +E E  +  ++ N L+    
Sbjct: 959  MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1007

Query: 607  AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 653
                  ++ E+   D+     E E+K ++       +E  + E  V  KK +      E 
Sbjct: 1008 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 654  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 713
            +K++ E +     +QI+DL+ +IAEL+ Q A  +E    A  R ++E  Q        K 
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1114

Query: 714  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 773
            +  +K+R     EL+  ++  Q   + ER     +   E++ R L +ELE    E     
Sbjct: 1115 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1162

Query: 774  VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 833
              + TL+    ++EL  K ++E+   ++ ++ E     +Q++   Q   Q V E  E   
Sbjct: 1163 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219

Query: 834  QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
                    ++ K  +    + K   E E  +L  E     +  +E   ++K       Q 
Sbjct: 1220 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1268

Query: 894  REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 948
            +E+  K       +  LN  V + Q  ++ +  + N +E +   L+  +  L S    +L
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1324

Query: 949  REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1008
            ++ +E+L +    +   S +L +LE E +  + ++  ++ A +N+ +            +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1373

Query: 1009 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
            ST   +L    K++Q   S +  L+ G +   ++E+E     +L QQ     EE      
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1423

Query: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1128
             L++   +  +E   +  ++   +Q +  LE        L           A++ +    
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 1129 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1187
            + R K+ + ++    L + LE  E  +L  T        E  +   +   +   ELE S+
Sbjct: 1484 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541

Query: 1188 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1238
                T+  E+K Q+ +L+++L       L  + +  + K Q   DL       ++K + L
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601

Query: 1239 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1291
            +R      +Y+   ED  ++          L+ +L+ +E + D A++  +E   ++ +LQ
Sbjct: 1602 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658

Query: 1292 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1351
             ++K  +   E       S DE+    +E       L+  + +LQE +    +    +A 
Sbjct: 1659 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1714

Query: 1352 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1405
            LE  E+ E   + L     L++   R+ + +  + EE ++E   +E  +  + K      
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 1406 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1460
              ++E+A    T Q ++   ++   QN+ +  +   + G     F  ++TIA LE +  +
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1832

Query: 1461 LQELTR---KLKERVTILVKQKD-----VLSHGEKE----EELKAMMHDLQITCSEMQQK 1508
            L+E      + K+  T  +KQKD     +L   E E    E+ K           +++++
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892

Query: 1509 VELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAV 1568
            +E    ES+++      L+ E+    E +     ++  L  S+     +T  V    +  
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK-SKLRRGNETSFVPSRRSGG 1951

Query: 1569 QKMVENLKKQISELKIKNQQLDLENTELSQ 1598
            ++++EN     SE +   +  D   T+ S+
Sbjct: 1952 RRVIENADG--SEEETDTRDADFNGTKASE 1979



 Score =  148 bits (374), Expect = 5e-35
 Identities = 253/1137 (22%), Positives = 493/1137 (43%), Gaps = 201/1137 (17%)

Query: 345  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 404
            A E+EL  TK    +A     + E++ L ++  Q+  EK  L+  L    +L +  A E+
Sbjct: 863  AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 916

Query: 405  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 453
                AA ++  E  L +++   EE ++R   L+ E +K  +Q+L        ++A +Q+L
Sbjct: 917  RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976

Query: 454  ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 502
            +LE+   +AK ++  + D + +   +N++L  E +LLE          AE+  + +NLT 
Sbjct: 977  QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1033

Query: 503  KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 558
            KL+   E++++E   +    + S  E    + +L    +++  Q   LQ Q+ EL+ +L 
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 559  -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 598
             +E   Q  + RL      KN+  +++    G I + +  L SE                
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 599  ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 652
                    L  ++++    ++++ +  +++  L+  L+++ R +E Q+ E      +A E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213

Query: 653  NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
             + ++ E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1269

Query: 710  E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 747
            E           +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q 
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329

Query: 748  SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
                E + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 807  CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 851
                 S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 852  RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 889
            R+     EK Q +F++             DE  +  AEA+E  KET    L R    +L 
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1504

Query: 890  LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 946
              +E E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1560

Query: 947  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1006
            EL+  E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620

Query: 1007 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1066
              +    +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D 
Sbjct: 1621 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1664

Query: 1067 LLSLQRAHEQ------AVKENVKMA----TEISRLQQRLQKLE-----PGLVMSSCLDEP 1111
               L+ A           KEN K A     ++ +LQ+ L   E       L      +E 
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724

Query: 1112 ATEFFGNTAEQTEPFLQQNRTKQ-----------VEGVTRRHVLSDLEDDEVRDLGSTGT 1160
            A+   G  A Q E    + R  Q           +E ++ R   +  + +++ +  +T  
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784

Query: 1161 SSVQRQEVKIEESEASVE----GFSELENSEETRTESW--ELKNQISQLQEQLMMLCADC 1214
            S+ Q+ E   ++ E   +       E+E + +++ +S    L+ +I+QL+EQ+     + 
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844

Query: 1215 DRAS----EKKQDLLFDVSVLKKKLKMLERIPEASPK-------YKLLYEDVSRENDCLQ 1263
              A+    +K + L   +  ++ + KM E+  E + K        K   E+   E+  + 
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904

Query: 1264 EELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
               R ++   DEA E+N+ +  EV  L+ +L++  E   +F+   +S     IEN +
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET--SFVPSRRSGGRRVIENAD 1959



 Score =  139 bits (351), Expect = 2e-32
 Identities = 242/1182 (20%), Positives = 493/1182 (41%), Gaps = 146/1182 (12%)

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 613
            LQ   +E   Q +   L       ++ E     +E +H   +EE N L   ++AE  +  
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 614  MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 673
              E+    +   + ELE+ +   E +L+E        +E+  Q+ + E   + +Q+ DL+
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 963

Query: 674  NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 733
             ++ E +     L+     A  + ++ + ++ V ++++   L ++ +L     L+ R++ 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1017

Query: 734  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 793
               +   E          EEK + LT +L+  H+  ++ L  +  L+KEE  ++ LEK +
Sbjct: 1018 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1064

Query: 794  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 853
            R+L+        +     +QI A+ +    K  E  ++AL  L+    Q+   L++ +  
Sbjct: 1065 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123

Query: 854  EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 911
            E    + ++D  ++  A  +    E  KR+      L +E E L+   ++ L+S   +  
Sbjct: 1124 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1174

Query: 912  -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 970
             R +  Q++  L+   + +      Q+ E++  H + + E  E L Q   ++    +  +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234

Query: 971  RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1017
             LE E+              QE +    KL A     ++ C   +R RAE++ ++ +LQ+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294

Query: 1018 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1062
            +               IK  +   S  S LQ   +++ EE  +     + L+Q E+  E 
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1352

Query: 1063 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
            N    L  Q   E   K+N++  ++T   +L    +KL+        L+E    F     
Sbjct: 1353 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1178
              T+ + ++         T+  +  +L DD V DL +     S++++++ K ++  A  +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468

Query: 1179 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1238
              S     E  R E+     +  + + + + L    + A E K++L     +LK +++ L
Sbjct: 1469 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 1239 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1298
                  S K     +DV +    L++  R +ET+ +E     +EL  E+   +D   ++E
Sbjct: 1524 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 1299 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1352
               +      E+       +NEE    + R   + E +L++   QR          E  L
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 1353 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1412
            ++LE++ D  I    +  EE + ++R +   +++ ++E          LE  +A     +
Sbjct: 1634 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1678

Query: 1413 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1471
              T + ++++ +            L+  Q+     +    + +LEK +L +EL   L  R
Sbjct: 1679 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731

Query: 1472 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1531
              +           +++  L+A +  L+    E Q  +E +     K  Q+   L NE+ 
Sbjct: 1732 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 1532 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1591
            T       +      L    +E+  K    + E A   K     K  I+ L+ K  QL+ 
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1835

Query: 1592 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1646
            +  + +++     + L++ +++L E+L Q E E   +   + + EK N     LK +LE 
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895

Query: 1647 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDELEK 1685
             + +S  + ++   L+ EL E       + +E + LK +L +
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937



 Score =  115 bits (287), Expect = 6e-25
 Identities = 233/1157 (20%), Positives = 474/1157 (40%), Gaps = 150/1157 (12%)

Query: 1014 RLQSKIKEMQQATSPLSMLQSG---CQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSL 1070
            RL +K+K + Q T     +Q+     Q   E + + +  L  L+Q    L E  ++L   
Sbjct: 843  RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 1071 QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1130
             +A  +   E  +M   ++  +Q L+++     M + L+E                 +++
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELEEILHE--MEARLEE-----------------EED 943

Query: 1131 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1190
            R +Q++   ++     L+ +E  +        +Q ++V  E     +E    + + +  +
Sbjct: 944  RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003

Query: 1191 TESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1250
                 L  +   L+E++  L  +     EK ++L         KLK       +  + +L
Sbjct: 1004 -----LSKERKLLEERISDLTTNLAEEEEKAKNLT--------KLKNKHESMISELEVRL 1050

Query: 1251 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1310
              E+ SR+   L++  R +E    +  E   +L A++  L+ +L K EE  E   +L + 
Sbjct: 1051 KKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE--ELQAALARL 1106

Query: 1311 YDEVKIENEELNVLVLRLQGKIEKLQESV-VQRCDCCLWEASLENLEIEPDGNILQLNQT 1369
             DE+  +N  L   +  L+G I  LQE +  +R      E    +L  E +    +L  T
Sbjct: 1107 DDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165

Query: 1370 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV 1429
            L+    +           K+E +       L E+ ++HE            +  R ++  
Sbjct: 1166 LDSTATQQEL------RAKREQEVTVLKKALDEETRSHE---------AQVQEMRQKHAQ 1210

Query: 1430 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1489
             +EE T  L       Q +   A L+  K  L++    L   + +L + K  + H  K++
Sbjct: 1211 AVEELTEQLE------QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH--KKK 1262

Query: 1490 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQE--------NSILRNEITTLNEEDSISN 1541
            +L+A + +LQ  CS+ ++    L  +  KLQ E        N      I    +  S+S+
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 1542 LKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1601
                T    QEE  QK   V  +   +++   +L+ Q+ E     Q L+   + L+ + S
Sbjct: 1323 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381

Query: 1602 QNQEKLQELN-------------QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCK 1648
             +++KLQ+               Q+  E L Q+ +E   +A ++ E+ K  L++EL+   
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQELDDLV 1440

Query: 1649 VQSST---LVSSLEAELSEVKIQTHIVQQENHLLK--DELEKMKQLHRCPDLS--DFQQK 1701
            V       LVS+LE +  + K    + +++N   K  DE ++ +   R  +       + 
Sbjct: 1441 VDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 1702 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1761
            +   L   E+L +  + L  E+    D ++    +   +  +++ +++ E Q   +K+QL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555

Query: 1762 VASQEKVQNLEDTVQNVNLQMSRMKS----DLRVTQQEKEALKQEVM-SLHK-QLQNAGG 1815
               ++++Q  ED    + + M  +K     DL+   ++ E  ++++   LH+ + +    
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615

Query: 1816 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1875
            +      A     L    K L       +   E+ +  ++  +LQ  +++ + EL  +R 
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARA 1673

Query: 1876 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMN----S 1931
               ++                T    E++  SL+ +  Q Q++ + A R   Q +     
Sbjct: 1674 SRDEI--------------FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1719

Query: 1932 LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1991
            L +EL +       L+ ++ +L+ ++ +++               +L+  Q     M  R
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEE--------------ELEEEQGNMEAMSDR 1765

Query: 1992 EQFLQLQRQLLQAERINQHLQEE----LENRTSETNTPQGNQEQLVTVMEERMIEVEQKL 2047
                 +++   QAE+++  L  E     +N ++     + N+E L + + E    V+ K 
Sbjct: 1766 -----VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE-LRSKLHEMEGAVKSKF 1819

Query: 2048 KLVKRLLQEKVNQLKEQLCKNTK-ADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLL 2106
            K     L+ K+ QL+EQ+ +  +   A  K L  ++ +L + L   E  +K AE+     
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879

Query: 2107 EEKIASLSNIVRNLTPA 2123
            E+  A +  + R L  A
Sbjct: 1880 EKGNARVKQLKRQLEEA 1896



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 57/277 (20%), Positives = 111/277 (40%), Gaps = 39/277 (14%)

Query: 323  QEILKALDFSLDGNINLTELTLALENELLVTKNSIH--QAALASFKAEIRHLLERVDQVV 380
            +E+ + L  SL G   L +    LE  +   +  +   Q  + +    +R   ++ +Q+ 
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 381  REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE-------EYKERIAAL 433
             E    RS   K E  +             +ER+N+    KL E       ++K  IAAL
Sbjct: 1778 NELATERSTAQKNESARQ-----------QLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 434  KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 493
            + ++ +  EQ+ Q+A +     +Q   K+  +++     + L +++  ++  +  E AEK
Sbjct: 1827 EAKIAQLEEQVEQEARE-----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881

Query: 494  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 553
                     +L+R LE        + +  S        +L +  +E       +  +V+ 
Sbjct: 1882 ---GNARVKQLKRQLE--------EAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
            L+S+L   R       +P + S    V  N+ G E E
Sbjct: 1931 LKSKL---RRGNETSFVPSRRSGGRRVIENADGSEEE 1964


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  156 bits (394), Expect = 2e-37
 Identities = 241/1122 (21%), Positives = 486/1122 (43%), Gaps = 201/1122 (17%)

Query: 337  INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLD-KAEK 395
            + + E  LA EN L  T+    Q+ L + K +++  L+   ++  E E+LR+ L  K ++
Sbjct: 855  VKVREKQLAAENRL--TEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQE 912

Query: 396  LKSLMASEVDDHHAAIERRNE--YNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRL 453
            L+ +      D  A +E   E   +L+   ++ ++ I  L+ +L +E      ++ +Q+L
Sbjct: 913  LEEIC----HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE------ESARQKL 962

Query: 454  ELEQ-----EIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNL 508
            +LE+     +++K + E+  + D+     KE   LE+ + E    L E E  +  L + L
Sbjct: 963  QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-L 1021

Query: 509  ENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQ---- 564
            +N       DL+        Q + L + R + E     L DQ+ ELQ+++ E + Q    
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081

Query: 565  GRVLRLPLKNSPSEEVEAN----------SGGIEPEHGLGSEECN--------------- 599
               L+  L     E  + N          S   E +  L SE  +               
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141

Query: 600  -----PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM 654
                  L  ++++    ++++ +  +++  L+  LE++ + +E Q+ E      +A E +
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201

Query: 655  KQRHENETH---TLEKQISDLKNEIAELQGQAAVLKEAHHEATCRH---EEEKKQLQVKL 708
             ++ E        LEK    L+NE  EL  +  VL +   ++  +    E + ++LQVK 
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKF 1261

Query: 709  ---EEEKTHLQEKL-RLQHEME-----------LKARLTQAQASFEREREGLQSSAWTEE 753
               E  +T L +K+ +LQ E++             ++LT+  ++ E + +  Q     E 
Sbjct: 1262 NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN 1321

Query: 754  KVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKH----QRELQEGREKMETE-- 806
            + +  L+ +L+Q   E+ +    +  LE+EE  K  LEK       ++ + ++KME    
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSF---REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG 1378

Query: 807  CNRRTSQIEAQFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQRE---- 853
            C     +++ + Q D + +++R E        L+  + R +QEL DL    + QR+    
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438

Query: 854  -EKSQWEF-----EKDELTQECAEAQELLKETLKREKTTSLVLTQ----------EREML 897
             EK Q +F     E+  ++ + AE ++  +   + ++T +L L +          E E L
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERL 1498

Query: 898  EKTY------------------------KEHLNSMVVERQQLLQDLEDLRNVSETQQSLL 933
             K +                        K  L   V E +  L++LED    +E  +  L
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558

Query: 934  SDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENI 993
               +  +K+  +R+L+ R+E   Q+   ++   +++  +E E + ER++    + A + +
Sbjct: 1559 EVNLQAMKAQFERDLQGRDE---QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL 1615

Query: 994  H------KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGD 1047
                   +A  ++A++ R E   ++ +LQ+++K+  +        +   +++ + +    
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE--EILAQAKENEK 1673

Query: 1048 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQ-------QRLQKLEP 1100
               S+  +  QL EE    L + +RA  QA +E  ++A EI+          +  ++LE 
Sbjct: 1674 KLKSMEAEMIQLQEE----LAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729

Query: 1101 GLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGT 1160
             +     L+E   E  GNT                E +  R   ++L+ D++    +   
Sbjct: 1730 RIAQ---LEEELEEEQGNT----------------ELINDRLKKANLQIDQINTDLNLER 1770

Query: 1161 SSVQ-----RQEVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLMMLCAD 1213
            S  Q     RQ+++ +  E  V+   E+E + +++ ++    L+ +I+QL+EQL      
Sbjct: 1771 SHAQKNENARQQLERQNKELKVK-LQEMEGTVKSKYKASITALEAKIAQLEEQL------ 1823

Query: 1214 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1273
             D  ++++Q     V   +KKLK +    +   +    Y+D   + D     L+ ++ + 
Sbjct: 1824 -DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD---QADKASTRLKQLKRQL 1879

Query: 1274 DEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVK 1315
            +EA E  +   A   +LQ EL   E+ TET  ++ +    +K
Sbjct: 1880 EEAEEEAQRANASRRKLQREL---EDATETADAMNREVSSLK 1918



 Score =  153 bits (386), Expect = 2e-36
 Identities = 241/1117 (21%), Positives = 472/1117 (42%), Gaps = 202/1117 (18%)

Query: 427  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
            +E + A + EL K RE+  Q A + RL   + ++     E        L L+E  + E E
Sbjct: 844  EEEMMAKEEELVKVREK--QLAAENRLTEMETLQSQLMAEK-------LQLQEQLQAETE 894

Query: 487  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 546
            L   AE+L     LT K Q      L E   DL+    E   +EER   ++ E ++    
Sbjct: 895  LCAEAEELRA--RLTAKKQE-----LEEICHDLEARVEE---EEERCQHLQAEKKK---- 940

Query: 547  LQDQVDELQSELEEYRAQGRVLRLP-------LKNSPSEEV--EANSGGIEPEHGLGSEE 597
            +Q  + EL+ +LEE  +  + L+L        LK    E++  E  +  +  E  L  + 
Sbjct: 941  MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000

Query: 598  CNPLNMSI----EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQEN 653
                  ++    E    + ++K +H   I     +LE+++R  EKQ  E         E 
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMIT----DLEERLRREEKQRQEL--------EK 1048

Query: 654  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV------K 707
             +++ E ++  L  QI++L+ +IAEL+ Q A  +E    A  R EEE  Q  +      +
Sbjct: 1049 TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108

Query: 708  LEEEKTHLQEKLRLQHEM-------------ELKARLTQAQASFEREREGLQSSAWTEEK 754
            LE + + LQE L  +                EL+A  T+ + + +      +  +  E++
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168

Query: 755  VRGLTQELEQ---FHQEQLTSLVEKHTLEKEELRKEL--LEKHQRELQEGREKMETECNR 809
            V  L + LE+    H+ Q+  + +KH+   EEL ++L   ++ +  L++ ++ +E E   
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228

Query: 810  RTSQIEA--QFQSDCQKVTERCESALQSLE------GRYRQELKD--------------L 847
              ++++   Q + D +   ++ E+ LQ L+       R R EL D              L
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288

Query: 848  QEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNS 907
              Q   + S+   +   L  +  + QELL+E  +++ + S  L Q  +  + +++E L  
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE-KNSFREQLEE 1347

Query: 908  MVVERQQLLQDLEDLRNVSETQQSLLSDQI--LELKSSHKRELREREEVLCQAGASEQLA 965
                +  L + +  L       +  + D +  LE     KR+L++  E L Q    +  A
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA 1407

Query: 966  SQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRER-------------AEMSTEI 1012
              +LE+ +    QE  ++   L+ +++  ++ C    +++             A+ + E 
Sbjct: 1408 YDKLEKTKTRLQQELDDL---LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464

Query: 1013 SRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQ-----QGEQLLEENGDV- 1066
             R +++ +E +  T  LS+ ++      EE +E    L  L      + E L+    DV 
Sbjct: 1465 DRAEAEAREKE--TKALSLARA-----LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVG 1517

Query: 1067 -----LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE 1121
                 L   +RA EQ V+E   M T++  L+  LQ  E   +      +     F    +
Sbjct: 1518 KSVHELEKSKRALEQQVEE---MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574

Query: 1122 QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1181
              +   ++ + + V  V  R + ++LED+  R   S   ++ ++ E+ +++ EA      
Sbjct: 1575 GRDEQSEEKKKQLVRQV--REMEAELEDE--RKQRSMAVAARKKLEMDLKDLEA------ 1624

Query: 1182 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE-- 1239
             ++++ + R E+ +   Q+ +LQ Q+     + D     ++++L      +KKLK +E  
Sbjct: 1625 HIDSANKNRDEAIK---QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE 1681

Query: 1240 --RIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1297
              ++ E     +       +E D L +E+     +   ALE  + L A + +L++EL++ 
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741

Query: 1298 EEVTE-----------------TFLSLEKSY--------DEVKIENEELNVLVLRLQGKI 1332
            +  TE                 T L+LE+S+         +++ +N+EL V +  ++G +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV 1801

Query: 1333 -------------------EKLQESVVQRCDCC----LWEASLENLEIEPDG---NILQL 1366
                               E+L     +R   C      E  L+++ ++ D    N  Q 
Sbjct: 1802 KSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861

Query: 1367 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEK 1403
                ++   R++ +   +EE ++E Q    + + L++
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898



 Score =  141 bits (355), Expect = 8e-33
 Identities = 230/1020 (22%), Positives = 447/1020 (43%), Gaps = 181/1020 (17%)

Query: 307  VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 366
            +E++    + + +E  Q IL+  +  L     L E  +A E    +T+      +LA  K
Sbjct: 964  LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA-EFTTNLTEEEEKSKSLAKLK 1022

Query: 367  AEIRHLLERVDQVVREKEKLRSDLDKAEK----------------------LKSLMASEV 404
             +   ++  +++ +R +EK R +L+K  +                      LK  +A + 
Sbjct: 1023 NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082

Query: 405  DDHHAAIERRNE------YNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQE 458
            ++  AA+ R  E        L+K+  E + +I+ L+ +L  ER     +A KQ+ +L +E
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKI-RELESQISELQEDLESERAS-RNKAEKQKRDLGEE 1140

Query: 459  IEKAKTEENYIRDRLALSLKENSRLENEL-------------------------LENAEK 493
            +E  KTE     D  A   +  S+ E E+                          +  E+
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200

Query: 494  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 553
            LAE    T +++ NLE         L+    E   + + L Q + + E + + ++ Q+ E
Sbjct: 1201 LAEQLEQTKRVKANLEKAKQ----TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE 1256

Query: 554  LQSELEEYRAQGRVLRLPLKNSPSE-EVEA-NSGGIEPEHGLGSEECNPLNMSIEAELV- 610
            LQ +  E    G  +R  L +  ++ +VE  N  G+  +    S +      ++E++L  
Sbjct: 1257 LQVKFNE----GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312

Query: 611  IEQMKEQHHRDICCLRLEL---EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEK 667
             +++ ++ +R    L  +L   ED+   + +QL+E        +E  K   E +  TL  
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE--------EEEAKHNLEKQIATLHA 1364

Query: 668  QISDLKNEIAELQGQAAVLKEAHH------EATCRHEEEKKQLQVKLEEEKTHLQEKL-- 719
            Q++D+K ++ +  G     +E         E   +  EEK     KLE+ KT LQ++L  
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424

Query: 720  ---RLQHEMELKARLTQAQASFER--------------EREGLQSSAWTEE-KVRGLTQE 761
                L H+ +    L + Q  F++              ER+  ++ A  +E K   L + 
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484

Query: 762  LEQFHQE--QLTSLVEKHTLEKEEL--RKELLEKHQRELQEGREKMETECNRRTSQIEAQ 817
            LE+  ++  +L  L ++   E E+L   K+ + K   EL++ +  +E +     +Q+E +
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE-E 1543

Query: 818  FQSDCQKVTE---RCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 874
             + + Q   +   R E  LQ+++ ++ ++L+   EQ  E+K Q       L ++  E + 
Sbjct: 1544 LEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ-------LVRQVREMEA 1596

Query: 875  LLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLS 934
             L++  +++++ ++   ++ EM  K  + H++S    R + ++ L  L       Q+ + 
Sbjct: 1597 ELEDE-RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL-------QAQMK 1648

Query: 935  DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 994
            D + EL  +       REE+L QA  +E    ++L+ +E E  Q ++E    L A E   
Sbjct: 1649 DCMRELDDTR----ASREEILAQAKENE----KKLKSMEAEMIQLQEE----LAAAERAK 1696

Query: 995  KATCETADRERAEMSTEISRLQSK----IKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL 1050
            +     A +ER E++ EI+    K    ++E ++  + ++ L+        EE +G+  L
Sbjct: 1697 R----QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL-----EEEQGNTEL 1747

Query: 1051 ---SLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATE--ISRLQQRLQKLEPGLVMS 1105
                L +   Q+ + N D  L+L+R+H Q   EN +   E     L+ +LQ++E G V S
Sbjct: 1748 INDRLKKANLQIDQINTD--LNLERSHAQK-NENARQQLERQNKELKVKLQEME-GTVKS 1803

Query: 1106 ------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR--RHVLSDLEDD------- 1150
                  + L+    +       +T+   +Q   KQV    +  + VL  ++D+       
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKE--RQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861

Query: 1151 -EVRDLGSTGTSSVQRQ-EVKIEESEASVEGFSELENSEETRTESWELKN-QISQLQEQL 1207
             +  D  ST    ++RQ E   EE++ +     +L+   E  TE+ +  N ++S L+ +L
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score =  117 bits (294), Expect = 9e-26
 Identities = 265/1323 (20%), Positives = 519/1323 (39%), Gaps = 258/1323 (19%)

Query: 867  QECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS 926
            Q C       K   KR++  + +     ++L++    +L     +  +L   ++ L  VS
Sbjct: 787  QACCRGYLARKAFAKRQQQLTAM-----KVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVS 841

Query: 927  ETQQSLLSDQ-----ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 981
              ++ +++ +     + E + + +  L E E +  Q  A E+L  Q   + E E   E +
Sbjct: 842  RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQAETELCAEAE 900

Query: 982  EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSML----QSGCQ 1037
            E+ ++L A +   +  C   +    E       LQ++ K+MQQ    L       +S  Q
Sbjct: 901  ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 960

Query: 1038 VIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK 1097
             +  E+V  +  L  L++ + +LE+                 +N K+A E   L+ R+  
Sbjct: 961  KLQLEKVTTEAKLKKLEEEQIILED-----------------QNCKLAKEKKLLEDRI-- 1001

Query: 1098 LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH--VLSDLEDDEVRDL 1155
                            EF  N  E+ E      ++K +  +  +H  +++DLE+   R+ 
Sbjct: 1002 ---------------AEFTTNLTEEEE------KSKSLAKLKNKHEAMITDLEERLRRE- 1039

Query: 1156 GSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCD 1215
                    ++Q  ++E++   +EG            +S +L +QI++LQ Q+  L     
Sbjct: 1040 --------EKQRQELEKTRRKLEG------------DSTDLSDQIAELQAQIAELKMQLA 1079

Query: 1216 RASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1275
            +  E+ Q  L  V     +  M      A  K + L   +S     LQE+L       ++
Sbjct: 1080 KKEEELQAALARVEEEAAQKNM------ALKKIRELESQISE----LQEDLESERASRNK 1129

Query: 1276 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKL 1335
            A +  ++L  E+  L+ EL+   + T     L    ++      E+N+L   L+ + +  
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ------EVNILKKTLEEEAKT- 1182

Query: 1336 QESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLE 1395
                         EA ++ +  +    + +L + LE+     + V   +E+ KQ  +   
Sbjct: 1183 ------------HEAQIQEMRQKHSQAVEELAEQLEQ----TKRVKANLEKAKQTLENER 1226

Query: 1396 GNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELE 1455
            G  +L  +VK      L G   +  +R +V+ Q        L   Q K  + +    EL 
Sbjct: 1227 G--ELANEVKV----LLQGKGDSEHKRKKVEAQ--------LQELQVKFNEGERVRTELA 1272

Query: 1456 LEKTKLQ-ELTRKLKERVTILVKQKDVLSHGEKEE--ELKAMMHDLQITCSEMQQKVELL 1512
             + TKLQ EL     + VT L+ Q D  S    ++   L++ + D Q    E  ++   L
Sbjct: 1273 DKVTKLQVEL-----DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327

Query: 1513 RYESEKLQQENSILRNEITTLNEEDSISNLK--LGTLNGSQEEMWQKTE-------TVKQ 1563
              + ++++ E +  R ++    EE++  NL+  + TL+    +M +K E       T ++
Sbjct: 1328 STKLKQVEDEKNSFREQLE--EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385

Query: 1564 ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQK----------NSQNQEKLQELNQR 1613
                +QK +E L ++  E      +L+   T L Q+            Q+   L++  ++
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445

Query: 1614 LTEMLCQ-------------------KEKEPGNSALEEREQEKFNLKEELERCKVQSSTL 1654
              ++L +                   +EKE    +L    +E    K ELER   Q  T 
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505

Query: 1655 VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLK 1714
            +  L +   +V    H +++    L+ ++E+MK                           
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK--------------------------T 1539

Query: 1715 EKEALSEELNSCVD-KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLED 1773
            + E L +EL +  D KL     L+   A  +++ +  + QS   K QLV    +V+ +E 
Sbjct: 1540 QLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLV---RQVREMEA 1596

Query: 1774 TVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQ 1833
             +++   Q S   +  +  + + + L+  + S +K            E       L  Q 
Sbjct: 1597 ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN---------RDEAIKQLRKLQAQM 1647

Query: 1834 KRLSWDKLDHLMNEEQQLLWQ--ENER----LQTMVQNTKAELTHSREKVRQLESNLLPK 1887
            K     +LD      +++L Q  ENE+    ++  +   + EL  +    RQ +      
Sbjct: 1648 KD-CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK 1947
              +  N SG      +EK  L+    Q ++E             LE+E     L N+ LK
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEE-------------LEEEQGNTELINDRLK 1753

Query: 1948 KKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQ------LQRQL 2001
            K  +++D+   ++   RS A  + +      Q L++Q   +  + Q ++       +  +
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENAR----QQLERQNKELKVKLQEMEGTVKSKYKASI 1809

Query: 2002 LQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQE----- 2056
               E     L+E+L+N T E         +    +++ +++V+ + +  ++   +     
Sbjct: 1810 TALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAS 1869

Query: 2057 -KVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSN 2115
             ++ QLK QL      +   ++    NA   K     E   +TA+  N     +++SL N
Sbjct: 1870 TRLKQLKRQL------EEAEEEAQRANASRRKLQRELEDATETADAMN----REVSSLKN 1919

Query: 2116 IVR 2118
             +R
Sbjct: 1920 KLR 1922



 Score =  100 bits (249), Expect = 2e-20
 Identities = 137/738 (18%), Positives = 320/738 (43%), Gaps = 62/738 (8%)

Query: 1426 QNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQ----ELTRKLKERVTILVKQKDV 1481
            Q + ++ +   L+  ++K    +  + E+E  +++L     +L  +L+    +  + +++
Sbjct: 843  QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 902

Query: 1482 LSH-GEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSIS 1540
             +    K++EL+ + HDL+    E +++ + L+ E +K+QQ    L  ++    EE +  
Sbjct: 903  RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE--EEESARQ 960

Query: 1541 NLKLG--TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQ 1598
             L+L   T     +++ ++   ++ +N  + K  + L+ +I+E      + + ++  L++
Sbjct: 961  KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK 1020

Query: 1599 KNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSL 1658
              ++++  + +L +RL     +K+++       + E +  +L +++   + Q + L   L
Sbjct: 1021 LKNKHEAMITDLEERLRRE--EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078

Query: 1659 EAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1718
              +  E++     V++E       L+K+++L     +S+ Q+ + S  +   K  K+K  
Sbjct: 1079 AKKEEELQAALARVEEEAAQKNMALKKIRELES--QISELQEDLESERASRNKAEKQKRD 1136

Query: 1719 LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNV 1778
            L EEL +   +L  +  L+   A  +QE +S   Q  ++  + +  +E+ +  E  +Q +
Sbjct: 1137 LGEELEALKTELEDT--LDSTAA--QQELRSKREQEVNILKKTL--EEEAKTHEAQIQEM 1190

Query: 1779 NLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSW 1838
              + S+   +L    ++ + +K  +    + L+N  G+  A E+     G  + + +   
Sbjct: 1191 RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL-ANEVKVLLQGKGDSEHKR-- 1247

Query: 1839 DKLDHLMNEEQQLLWQENER-----------LQTMVQNTKAELTHSREKVRQLESNLLPK 1887
             K      +E Q+ + E ER           LQ  + N    L+ S  K  +L  +    
Sbjct: 1248 -KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL 1306

Query: 1888 HQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQ----MNSLEQELETIHLEN 1943
              +  +    +    ++KLSL  +  Q + E++    ++ +     ++LE+++ T+H + 
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV 1366

Query: 1944 EGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQ 2003
              +KKK       + +      TA         DL+ L Q+    V     L+  +  LQ
Sbjct: 1367 ADMKKK-------MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ 1419

Query: 2004 AERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMI----------------EVEQKL 2047
             E ++  L +    R S  N  +  ++    + EE+ I                E E K 
Sbjct: 1420 QE-LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478

Query: 2048 KLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLE 2107
              + R L+E + Q  E    N +    ++DL      + K++   E+ ++  E++   ++
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538

Query: 2108 EKIASLSNIVRNLTPAPL 2125
             ++  L + ++    A L
Sbjct: 1539 TQLEELEDELQATEDAKL 1556


>gi|81295809 pericentrin [Homo sapiens]
          Length = 3336

 Score =  155 bits (393), Expect = 3e-37
 Identities = 412/1932 (21%), Positives = 780/1932 (40%), Gaps = 316/1932 (16%)

Query: 395  KLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 454
            +L++L  S  + H A +E   + NL+K  E     +  + N  R +   +LQ   +  LE
Sbjct: 246  ELEALRLSLSNMHTAQLEL-TQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELE 304

Query: 455  LEQEIEKAKTEENYIR---------DRLALSLKENSRLENELLEN--AEKLAEYENLTNK 503
            L +E    + EE  +R         ++L   +++N+++   L E+  +EK    ENL  +
Sbjct: 305  LLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKE 364

Query: 504  LQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL----QDQVDELQSELE 559
            L    ++ + +         AE   + E++ Q +N+ ER  R L    Q  +++L+ +L+
Sbjct: 365  LSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQ 424

Query: 560  EYRAQGRVLR-LPLKNSPSE-----EVEANSGGIEPEHGLGSEECNPLNMSIEAELV--- 610
                 GR L  L  K   SE     E+E      E       EE   L   +++      
Sbjct: 425  S--EHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQ 482

Query: 611  ------------------IEQMKE----QHHRDICCLRLELEDKVRHYEKQLDETVVSCK 648
                              +EQ+K+    QH  ++  LR+  E K+R  EK   E +   +
Sbjct: 483  ELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQ 542

Query: 649  KAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKL 708
              Q     R +    ++E  +S +  E    +G+   + E   E   RH+E   + Q +L
Sbjct: 543  --QRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPE---RHKESLPRFQAEL 597

Query: 709  EEEKTH----LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ 764
            EE   H    L+  L +QHE  +  R     ++   E        W  E   G +QEL  
Sbjct: 598  EESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHE--------WRLEPSEGHSQELPW 649

Query: 765  FHQE-----QLTSLVEK--HTLEKEELRKELLEKHQRELQEGREKMETECNRR---TSQI 814
             H +      L +  E+    L  E   K  L   Q EL+E  E ++ E NR      Q 
Sbjct: 650  VHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIE-NRNLYGKLQH 708

Query: 815  EAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 874
            E + + D +KV        Q      +Q+ + ++++ + +++ W+  K+EL +E  E   
Sbjct: 709  ETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLT 768

Query: 875  L----LKETLKREKTTSL--VLTQEREMLEKTYKEHLNSMVVER---------QQLLQDL 919
            L    L+E  + EK T +     +E EM +   ++    + +ER         QQL QDL
Sbjct: 769  LMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDL 828

Query: 920  --EDLRNVSETQQS-------------LLSDQILELKSSHKRELREREEVLCQAGAS--- 961
              +D  + S+  +              +  D  L+L  +  R L ER+E+  +  A    
Sbjct: 829  TSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDA 888

Query: 962  --EQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA-----TCETADRERAEMSTEISR 1014
              ++   Q    L++  ++ +Q+++S    +E  H+A     T     ++ A ++  ++ 
Sbjct: 889  FLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAE 948

Query: 1015 LQSK---------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQG--EQLLEEN 1063
            LQ+K          + +    S  S   S  Q I EE  +   AL LL+    EQL +++
Sbjct: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQ---ALELLRADFEEQLWKKD 1005

Query: 1064 G-------DVLLSLQRAHE---QAVKENVK------MATEISRLQQRLQKLEPGLVMSSC 1107
                      L  L+R HE   Q+V+++++      +A  ++   Q + + E G    + 
Sbjct: 1006 SLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTA 1065

Query: 1108 LDEPATEFFGNTAEQTEPFLQQNR-TKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQ 1166
            L E   E     + Q +PF Q+ + +  ++   + H +  L+D             V   
Sbjct: 1066 LHE-KEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD------------QVLSL 1112

Query: 1167 EVKIEESEASVEGFSELENSEETR-TESWELKNQISQLQEQLMMLCADCDRASEKKQDLL 1225
              +IEE        SELE  ++ R  E+ E  N +S L+  + +  ++     +  + LL
Sbjct: 1113 SHEIEECR------SELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLL 1166

Query: 1226 -FDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELT 1284
                  L+  + +  RI E   +  L  +D       L     + ET  D AL       
Sbjct: 1167 GLFGETLRAAVTLRSRIGE---RVGLCLDDAG-AGLALSTAPALEETWSDVALPELDRTL 1222

Query: 1285 AEVFRLQDELKKMEEVTETFLSLEKSYDEVKIE-NEELNVLVLRLQGKIEKLQESVVQRC 1343
            +E   +    +    + E+FL   +S  E +         L L + G +E   +S  Q  
Sbjct: 1223 SECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLE 1282

Query: 1344 DCCLWEASLE---NLEIEPDGNILQLNQTLEECVPRVRSVH-HVIEECKQENQYLEG--- 1396
            +     +  E   + + E    +++ +Q L EC+    +    +  E  +    LEG   
Sbjct: 1283 EARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKV 1342

Query: 1397 NTQLLEKVKAHEIAWLHGTI-----QTHQERPRVQNQVILEENTTLLGFQDKHFQHQATI 1451
             T  L++V A +    H  +        Q +   Q Q  L E  T L  + +     A  
Sbjct: 1343 ETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEA 1402

Query: 1452 AELELEK-----TKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQ 1506
             E  L K     TK Q  TRK  E+    +  +  +   E EE+L          C++  
Sbjct: 1403 REAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQ-----HRGCAKQA 1457

Query: 1507 QKVELLRYESEKLQQENSILRNEITTLNE------------EDSISNLKLGTLNGSQEEM 1554
            + V  L  +   L +    LRN+   ++E            +  I  L+      ++ + 
Sbjct: 1458 EAVTALEQQVASLDKH---LRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQP 1514

Query: 1555 WQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQE---KLQELN 1611
            W   ++   + A +   VE L++++ E   +  +L ++     ++    +E   +L+E+N
Sbjct: 1515 WGPRDS---QQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMN 1571

Query: 1612 QRLTEMLC--QKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEA--------- 1660
              + + +   Q+E E   + ++  EQ+K  LK++     + +STL S+L+A         
Sbjct: 1572 INIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSG 1631

Query: 1661 ---ELSEVKI---QTHIVQQENHL--LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1712
               E  E+++   Q  ++++E+ +  LK++LEKMK         D + K   +L  N KL
Sbjct: 1632 SPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK--------GDLESKNEEILHLNLKL 1683

Query: 1713 LKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLE 1772
              +    +  L    ++     ++  R + +++ + + E+   + K       E+++ L 
Sbjct: 1684 DMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLH 1743

Query: 1773 DTVQNVNLQMSRMKSDL-RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHN 1831
            + ++ +  ++S M   +  V+  +  +L+ E++        AGG           + L  
Sbjct: 1744 EVIEKLQHELSLMGPVVHEVSDSQAGSLQSELL-----CSQAGGPRGQALQGELEAALEA 1798

Query: 1832 QQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTK--AELTHSREKVRQLESNLLPKHQ 1889
            +      + L  L+ ++++   Q  E LQ  +Q  +  AEL     ++ +LE N+  +  
Sbjct: 1799 K------EALSRLLADQERRHSQALEALQQRLQGAEEAAEL-----QLAELERNVALREA 1847

Query: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949
            +  + +  +   ++ + +LK       KE + A R + ++++L Q       E E +   
Sbjct: 1848 EVEDMASRI---QEFEAALK------AKEATIAERNL-EIDALNQRKAAHSAELEAVLLA 1897

Query: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPM-----VPREQFLQLQRQL--L 2002
              ++  + +E Q L + A P       +LQ L+ Q   +     V  ++FL+ Q +L   
Sbjct: 1898 LARI-RRALEQQPLAAGAAPP------ELQWLRAQCARLSRQLQVLHQRFLRCQVELDRR 1950

Query: 2003 QAERINQHL-------QEELENRTSETNT-----------------PQGN-QEQLVTVME 2037
            QA R   H        Q  ++       T                 PQG+ Q  LVT+ +
Sbjct: 1951 QARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTLKD 2010

Query: 2038 ERMIEVE---QKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQ 2094
              + + E     L + +R LQ ++  +K ++  + +     K+  +E+ QL K +++  Q
Sbjct: 2011 APLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPK-VDLVAQ 2069

Query: 2095 RQKTAEKKNYLL 2106
             ++  EK N LL
Sbjct: 2070 VKQLQEKLNRLL 2081



 Score =  145 bits (365), Expect = 5e-34
 Identities = 329/1593 (20%), Positives = 624/1593 (39%), Gaps = 200/1593 (12%)

Query: 305  ASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALAS 364
            A++E++ +  Q E        L+ L+F    +    E  L LEN       + ++   A 
Sbjct: 414  AAIEKLREDLQSE----HGRCLEDLEFKFKESEK--EKQLELEN-----LQASYEDLKAQ 462

Query: 365  FKAEIRHLLERVDQVVREK-------EKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEY 417
             + EIR L  ++D     +       E+L +   + E L+ L   E   H + +E+   Y
Sbjct: 463  SQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIY 522

Query: 418  ---NLRKLDEEYKERIAALKNELRKEREQILQ---QAGKQRLELEQEIEKAKTEE----- 466
                LR  ++ Y+E +  L+  L+  RE  L    + G   + LE++ EK + +      
Sbjct: 523  FEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELE 582

Query: 467  ----NYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS 522
                     R    L+E+ R + E LE+   +    +++++    +E         L+PS
Sbjct: 583  PERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCC--VETSALGHEWRLEPS 640

Query: 523  SAE------FFLQEERLTQMRNEYERQCRVL------QDQVDELQSELEEYRAQGRVLRL 570
                       LQ  +   +  + ER  RVL      + Q+  LQ+EL+E     ++   
Sbjct: 641  EGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENR 700

Query: 571  PLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE 630
             L      E        + +H L  +    LN    A+   E MK++  R     ++  E
Sbjct: 701  NLYGKLQHETRLKDDLEKVKHNLIEDHQKELN---NAKQKTELMKQEFQRKETDWKVMKE 757

Query: 631  DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEK-----------QISDLKNEIAEL 679
            +  R  E++L   ++  ++  E+ KQ   N+    E            QI DL+  + E 
Sbjct: 758  ELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQ 817

Query: 680  QGQAAVLKE------AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 733
            QG+   L++      A H + C  E    Q     E    H++E   LQ        L  
Sbjct: 818  QGRLQQLEQDLTSDDALHCSQCGREPPTAQ---DGELAALHVKEDCALQ--------LML 866

Query: 734  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 793
            A++ F  ER+ +      E+      QE ++ H  +L  L E+H  +   +  EL  +HQ
Sbjct: 867  ARSRFLEERKEITEKFSAEQDA--FLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQ 924

Query: 794  RELQEGREKMETECNR----RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQE 849
              L E    +E++       R ++++ +  +D   +  R  S+L SLE  Y  E + ++E
Sbjct: 925  AALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIRE 984

Query: 850  QQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMV 909
            + R+          EL +   E Q   K++L +      +LTQE E L++ ++  L S+ 
Sbjct: 985  EHRQAL--------ELLRADFEEQLWKKDSLHQT-----ILTQELEKLKRKHEGELQSV- 1030

Query: 910  VERQQLLQDL--EDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQ 967
              R  L  ++  E    V+   Q +      E  S  K  L E+EE L    A  Q    
Sbjct: 1031 --RDHLRTEVSTELAGTVAHELQGVHQG---EFGSEKKTALHEKEETLRLQSAQAQ---- 1081

Query: 968  RLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATS 1027
                      QE +E +S  L  +N H+   +    +   +S EI   +S+++ +QQ   
Sbjct: 1082 -------PFHQEEKESLSLQLQKKN-HQV--QQLKDQVLSLSHEIEECRSELEVLQQRRE 1131

Query: 1028 PLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATE 1087
                          E  EG   LS+L+    L       L    R       E ++ A  
Sbjct: 1132 -------------RENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVT 1178

Query: 1088 I-SRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSD 1146
            + SR+ +R+     GL    CLD+         A  T P L++  +        R +   
Sbjct: 1179 LRSRIGERV-----GL----CLDDAGA----GLALSTAPALEETWSDVALPELDRTLSEC 1225

Query: 1147 LEDDEVRDLGSTGTSSVQRQEVKIEESEA-----------SVEGFSELENSEETRTESWE 1195
             E   V ++ S    S       + E E            +V+G  E+      + E  E
Sbjct: 1226 AEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLE--E 1283

Query: 1196 LKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDV 1255
             +   S+ +++      +  +   K Q+LL     LK++      +     K +   E  
Sbjct: 1284 ARQIHSRFEKEFSFKNEETAQVVRKHQELL---ECLKEESAAKAELALELHKTQGTLEGF 1340

Query: 1256 SRENDCLQEELRMMETRYDEALENNKELTAEVFRL-QDELKKMEEVTETFLSLEKSYDEV 1314
              E   L+E L   E      +   + L  ++ +  Q++    EE T  +   E +  + 
Sbjct: 1341 KVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDA 1400

Query: 1315 KIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECV 1374
            +     L   V  L  +  + ++   +     L +  +   E+E      QL+Q    C 
Sbjct: 1401 EAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEE-----QLSQH-RGCA 1454

Query: 1375 PRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEEN 1434
             +  +V  + ++    +++L    Q +++  A      H   +  QE  R++ Q+     
Sbjct: 1455 KQAEAVTALEQQVASLDKHLRNQRQFMDEQAAERE---HEREEFQQEIQRLEGQLRQAAK 1511

Query: 1435 TTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ----KDVLSHGEKEEE 1490
                G +D   Q      E+EL + KL+E   KL E   + +++    + VL   E+ + 
Sbjct: 1512 PQPWGPRDS--QQAPLDGEVELLQQKLRE---KLDEFNELAIQKESADRQVLMQEEEIKR 1566

Query: 1491 LKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE--ITTLNEEDSISNLKLGTL- 1547
            L+ M  +++   +++Q++VE  +   + L+Q+  +L+ +   + L      S L  G   
Sbjct: 1567 LEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCP 1626

Query: 1548 --------NGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQK 1599
                     G + ++      + +  + V  + E L+K   +L+ KN+++   N +L  +
Sbjct: 1627 EPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQ 1686

Query: 1600 NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLE 1659
            NSQ    L+EL +  T +   K     +S +EE +    NL+E  +R + + +  +  L 
Sbjct: 1687 NSQTAVSLRELEEENTSL---KVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLH 1743

Query: 1660 AELSEVKIQTHIVQQENHLLKD-ELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1718
              + +++ +  ++    H + D +   ++    C        +  ++    E  L+ KEA
Sbjct: 1744 EVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGG--PRGQALQGELEAALEAKEA 1801

Query: 1719 LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNV 1778
            LS  L     +   S  LE     ++  +++ E Q A L+  +   + +V+++   +Q  
Sbjct: 1802 LSRLLAD--QERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEF 1859

Query: 1779 NLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1811
               +   ++ +     E +AL Q   +   +L+
Sbjct: 1860 EAALKAKEATIAERNLEIDALNQRKAAHSAELE 1892



 Score =  142 bits (357), Expect = 5e-33
 Identities = 322/1535 (20%), Positives = 598/1535 (38%), Gaps = 244/1535 (15%)

Query: 724  EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE- 782
            E E +  +T  ++  E E    QS A    ++  L   L   H  QL         EKE 
Sbjct: 216  EQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKET 275

Query: 783  ---ELRKELLEKHQRELQ--EGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837
               ELR+ L  +  +EL   + R++ E E  R       Q   + ++V  RC      L+
Sbjct: 276  ALTELREMLNSRRAQELALLQSRQQHELELLRE------QHAREKEEVVLRCGQEAAELK 329

Query: 838  GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREML 897
             + + E++   +  +  K  WE EKD           L  E L++E   S     E E L
Sbjct: 330  EKLQSEMEKNAQIVKTLKEDWESEKD-----------LCLENLRKE--LSAKHQSEMEDL 376

Query: 898  EKTYKEHLNSMVVERQQLLQDLED----LRNVSETQQSLLSDQILELKSSHKRELREREE 953
            +  +++ L     E +++ QD       LRN+    Q+ +     +L+S H R L + E 
Sbjct: 377  QNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEF 436

Query: 954  VLCQAGASEQLASQRL----ERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMS 1009
               ++   +QL  + L    E L+ +  +E + + S+L +     +   E  ++  A  S
Sbjct: 437  KFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTS 496

Query: 1010 TEISRLQSKIKEMQQATSPLSMLQSGCQ-VIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
                  Q K +E  Q  S L  L+   +  + + E      L+LLQQ             
Sbjct: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQ------------- 543

Query: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1128
             LQ A E A+ ++V++      L+++ +K     V     DE   E    +  + +  L+
Sbjct: 544  RLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHV-----DELEPERHKESLPRFQAELE 598

Query: 1129 QNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEE 1188
            ++   Q+E +     L    +  V D     TS++   E ++E SE   +   EL     
Sbjct: 599  ESHRHQLEAL--ESPLCIQHEGHVSDRCCVETSAL-GHEWRLEPSEGHSQ---ELPWVHL 652

Query: 1189 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKY 1248
               +  +L+    +    L +        +E K  L    + LK+++++L +I   +   
Sbjct: 653  QGVQDGDLEADTERAARVLGL-------ETEHKVQLSLLQTELKEEIELL-KIENRNLYG 704

Query: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME-EVTETFLSL 1307
            KL +E  +R  D L++    +   + + L N K+ T        EL K E +  ET   +
Sbjct: 705  KLQHE--TRLKDDLEKVKHNLIEDHQKELNNAKQKT--------ELMKQEFQRKETDWKV 754

Query: 1308 EKSYDEVKIENEE-LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQL 1366
             K  +E++ E EE L +++L L+ K E  +++++ + +  L EA +  L+ +    IL L
Sbjct: 755  MK--EELQREAEEKLTLMLLELREKAESEKQTIINKFE--LREAEMRQLQDQQAAQILDL 810

Query: 1367 NQTLEECVPRVRSVH-----------------------------HVIEECKQE-----NQ 1392
             ++L E   R++ +                              HV E+C  +     ++
Sbjct: 811  ERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR 870

Query: 1393 YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE--ENTTLLGFQDKHFQHQAT 1450
            +LE   ++ EK  A + A+L    Q  QE+   + Q++ E  +   L    +   +HQA 
Sbjct: 871  FLEERKEITEKFSAEQDAFL----QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAA 926

Query: 1451 IAEL--ELEKTKLQELTRKLKERVTILVKQKDVLS--HGEKEEELKA-MMHDLQITCSEM 1505
            + EL   LE  +   L  ++ E  T        L   H    + L++  + + Q    E 
Sbjct: 927  LGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEH 986

Query: 1506 QQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQEN 1565
            +Q +ELLR + E+   +   L   I T  E + +     G L   ++ +  +TE   +  
Sbjct: 987  RQALELLRADFEEQLWKKDSLHQTILT-QELEKLKRKHEGELQSVRDHL--RTEVSTELA 1043

Query: 1566 AAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEP 1625
              V   ++ + +     + K    + E T L  +++Q Q   QE  + L+  L +K    
Sbjct: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEET-LRLQSAQAQPFHQEEKESLSLQLQKK---- 1098

Query: 1626 GNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAE-------LSEVKIQTHIVQQENHL 1678
             N  +++ + +  +L  E+E C+ +   L    E E       LS +K   ++   E   
Sbjct: 1099 -NHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGA 1157

Query: 1679 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVD------KLAK 1732
            L+D L ++        L  F + + + ++   +       + E +  C+D       L+ 
Sbjct: 1158 LQDALRRL--------LGLFGETLRAAVTLRSR-------IGERVGLCLDDAGAGLALST 1202

Query: 1733 SSLLEH-----------RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQ 1781
            +  LE            R  +   E  S    S+ ++   + S E V+  E  ++ V   
Sbjct: 1203 APALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQS 1262

Query: 1782 MSRMKSDLRVTQQEKEALKQEVMSLHKQLQ---NAGGKSWAPEIATHPS----------- 1827
            +S     L     +     +E   +H + +   +   +  A  +  H             
Sbjct: 1263 LSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAA 1322

Query: 1828 ------GLHNQQKRLSWDKLDHL--------MNEEQQLLWQENERLQTMVQNTKAELTHS 1873
                   LH  Q  L   K++            + +  L  E E L+  +Q    E    
Sbjct: 1323 KAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAAL 1382

Query: 1874 REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRK-------- 1925
            RE+  +L S              T    E  + +L++E +   KEQS   ++        
Sbjct: 1383 REECTRLWS----------RGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSAL 1432

Query: 1926 VSQMNSLEQELETIHLENEGLKKKQ---VKLDEQLMEM-QHLRSTATPSPSPHAWDLQLL 1981
            +SQM  LE ELE    ++ G  K+      L++Q+  + +HLR+             Q +
Sbjct: 1433 LSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRN-----------QRQFM 1481

Query: 1982 QQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMI 2041
             +QA       +  Q + Q L+ +       +    R S+     G  E L   + E++ 
Sbjct: 1482 DEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLD 1541

Query: 2042 EVE----QKLKLVKRLL--QEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQR 2095
            E      QK    +++L  +E++ +L+E      K  A +++   +   ++K LE  ++ 
Sbjct: 1542 EFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEV 1601

Query: 2096 QKTAEKKNYLLEEKIASLSNIVRNLTPAPLTSTPP 2130
             K  +  + LL   + S  +  R   P P + +PP
Sbjct: 1602 LKKQQMSSLLLASTLQSTLDAGR--CPEPPSGSPP 1634



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 191/863 (22%), Positives = 344/863 (39%), Gaps = 116/863 (13%)

Query: 264  LKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD---GMGHASVERILDTWQEEGI- 319
            L+R L +  F E+ R   T   + S IG RV  CLDD   G+  ++   + +TW +  + 
Sbjct: 1162 LRRLLGL--FGETLRAAVT---LRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALP 1216

Query: 320  ENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA------ALASFKAEIRHLL 373
            E  + + +  + S     ++ E++  +    L++  S+ +          S    +  L+
Sbjct: 1217 ELDRTLSECAEMS-----SVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLM 1271

Query: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
            E      R+ E+ R    + EK  S    E     A + R+++  L  L EE   + A L
Sbjct: 1272 EMALDSSRQLEEARQIHSRFEKEFSFKNEET----AQVVRKHQELLECLKEESAAK-AEL 1326

Query: 434  KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 493
              EL K  +  L+    +  +L++ +   +  E+    RL L L+    L  +L + A++
Sbjct: 1327 ALELHK-TQGTLEGFKVETADLKEVLAGKEDSEH----RLVLELES---LRRQLQQAAQE 1378

Query: 494  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCR----VLQD 549
             A       +L    E        D +   A    + E LT+ ++E  +Q       L  
Sbjct: 1379 QAALREECTRLWSRGEATAT----DAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLS 1434

Query: 550  QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAEL 609
            Q+  L+SELEE  +Q R          +++ EA +   +    L     N      + + 
Sbjct: 1435 QMKILESELEEQLSQHR--------GCAKQAEAVTALEQQVASLDKHLRN------QRQF 1480

Query: 610  VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRH-ENETHTLEKQ 668
            + EQ  E+ H      R E + +++  E QL +          + +Q   + E   L+++
Sbjct: 1481 MDEQAAEREHE-----REEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQK 1535

Query: 669  ISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELK 728
            + +  +E  EL    A+ KE+        EEE K+L+                  EM + 
Sbjct: 1536 LREKLDEFNEL----AIQKESADRQVLMQEEEIKRLE------------------EMNIN 1573

Query: 729  ARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL 788
             R   AQ   E E++        +  V+GL Q+ E   ++Q++SL+   TL+        
Sbjct: 1574 IRKKVAQLQEEVEKQ--------KNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRC 1625

Query: 789  LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848
             E       EG E ++ E  +R      + +S+   + E+ E     LE +  +E+  L 
Sbjct: 1626 PEPPSGSPPEGPE-IQLEVTQRAL---LRRESEVLDLKEQLEKMKGDLESK-NEEILHLN 1680

Query: 849  EQQREEKSQWEFEKDELTQECAEAQELLKETLKRE--KTTSLVLTQEREMLEKTYKEHLN 906
             +   + SQ      EL +E    + +   + + E  K T   L + ++ L+K   E + 
Sbjct: 1681 LKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIE 1740

Query: 907  SM--VVERQQLLQDLED--LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASE 962
             +  V+E+ Q    L    +  VS++Q   L  ++L  ++   R    + E+     A E
Sbjct: 1741 QLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKE 1800

Query: 963  QLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEM 1022
             L S+ L   E  H Q  + +  +L   E   +      +R  A    E+  + S+I+E 
Sbjct: 1801 AL-SRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEF 1859

Query: 1023 QQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ------ 1076
            + A      L++    I E  +E D            LE     L  ++RA EQ      
Sbjct: 1860 EAA------LKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAG 1913

Query: 1077 -AVKENVKMATEISRLQQRLQKL 1098
             A  E   +  + +RL ++LQ L
Sbjct: 1914 AAPPELQWLRAQCARLSRQLQVL 1936



 Score = 79.0 bits (193), Expect = 5e-14
 Identities = 148/684 (21%), Positives = 294/684 (42%), Gaps = 70/684 (10%)

Query: 1366 LNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQ-ERPR 1424
            L Q ++E   + + +  V  + +     L G++ LLE+++  +I    G +Q    E  R
Sbjct: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLE--KIIREQGDLQEKSLEHLR 2510

Query: 1425 VQNQVILEENTTLLGFQDK--HFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVL 1482
            + ++  L      L  Q +  H Q+Q  +  L   +T L     +  ++   L +Q ++L
Sbjct: 2511 LPDRSSLLSEIQALRAQLRMTHLQNQEKLQHL---RTALTSAEARGSQQEHQLRRQVELL 2567

Query: 1483 SHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1542
            ++  K E+ K +  DLQ T SE Q+K   ++   + L  E +++R+  + L E    S  
Sbjct: 2568 AY--KVEQEKCIAGDLQKTLSEEQEKANSVQ---KLLAAEQTVVRDLKSDLCESRQKSEQ 2622

Query: 1543 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1602
               +L   Q+E+ Q    +  +   ++  ++ L+ +  + +    QL+ E     Q+ SQ
Sbjct: 2623 LSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQ 2682

Query: 1603 NQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL----ERCK---VQSSTLV 1655
            + + L+EL   L     Q  +     AL+  +  K NL++EL     RC+    Q  + +
Sbjct: 2683 SAKALEELRASLETQRAQSSRL--CVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQL 2740

Query: 1656 SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKE 1715
            S L+ +L+  K +T    + +  L+ E    +QL +    +   Q   +  +  +K LKE
Sbjct: 2741 SELQKDLAAEKSRT---LELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQK-LKE 2796

Query: 1716 KEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTV 1775
            +++   +L + ++K+ + +L           Q+  E ++      L   +E    L+ TV
Sbjct: 2797 EKSRVVDLQAMLEKVQQQAL---------HSQQQLEAEAQKHCEALRREKEVSATLKSTV 2847

Query: 1776 QNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKR 1835
            + ++ Q   ++  L   +++   L+ E+   H +L+   G+  A               R
Sbjct: 2848 EALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAA---------------R 2892

Query: 1836 LSWDKLDHLMNEEQQLLWQENE----RLQTMVQNTKAELTHSREKVRQLES-NLLPKHQK 1890
             S +        EQ   WQ ++     L+   Q    ++   ++ VR LES + +P  + 
Sbjct: 2893 RSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL 2952

Query: 1891 HLNPSGTMNPTEQEKL-SLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949
            HL  +     ++ + L   +RE +  ++    A R ++   S   +  T++      +K 
Sbjct: 2953 HLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVD-RTVNDWTSSNEKA 3011

Query: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQ------LLQQ-----QACPMVPREQFLQLQ 1998
             + L   L E++   S  T S    A +LQ      LL+      +A   V +E+ L+L 
Sbjct: 3012 VMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEK-LELS 3070

Query: 1999 RQLLQAER-INQHLQEELENRTSE 2021
            R + + E+ +  HLQ+      SE
Sbjct: 3071 RAVSKLEKLLKHHLQKGCSPSRSE 3094



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 146/692 (21%), Positives = 270/692 (39%), Gaps = 97/692 (14%)

Query: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIER-----RNEYNLRKLDEEY------ 426
            QVV+E  +   ++   E    L  S++  H + +ER     R + +L++   E+      
Sbjct: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514

Query: 427  ---KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIR---DRLALSLKEN 480
                  I AL+ +LR    Q  ++    R  L     +   +E+ +R   + LA  +++ 
Sbjct: 2515 SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQE 2574

Query: 481  SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540
              +  +L +   +  E  N   KL    + V+ +   DL  S  +       L +++ E 
Sbjct: 2575 KCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEV 2634

Query: 541  ERQCRVLQDQVDELQS---ELEEYRAQGRVLRLPLKNSPSEEVEANS----------GGI 587
             +   +L  + +EL++   ELE  + +GR L+  L+      ++  S            +
Sbjct: 2635 LQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASL 2694

Query: 588  EPEHGLGSEECNPLNMSIEA-ELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVS 646
            E +    S  C  L     A + + ++++ +H R   C  L  +++ +  E Q D     
Sbjct: 2695 ETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSR---CEALLAQERSQLSELQKDLAAEK 2751

Query: 647  CKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQ--- 703
             +  + +   RHE     L +Q+S    E    Q       +AHH    + +EEK +   
Sbjct: 2752 SRTLELSEALRHE---RLLTEQLSQRTQEACVHQD-----TQAHHALLQKLKEEKSRVVD 2803

Query: 704  LQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELE 763
            LQ  LE+ +   Q+ L  Q ++E      +AQ   E  R   + SA  +  V  L  +  
Sbjct: 2804 LQAMLEKVQ---QQALHSQQQLE-----AEAQKHCEALRREKEVSATLKSTVEALHTQ-- 2853

Query: 764  QFHQEQLTSLVEKHTLEKEELRKELLEKHQR-ELQEGREKMETECNRRTSQIEAQ----F 818
               + +L   +E+   +   L+ EL + H R + QEGR+        R S   A+    +
Sbjct: 2854 ---KRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKW 2910

Query: 819  QSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKE 878
            Q D +K+ E     L+    R   ++K LQ+  R+ +S+ E     L    A        
Sbjct: 2911 QRDKEKLRE-----LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDA 2965

Query: 879  TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL 938
               RE+   L   ++R +          S  V+R      + D  + +E     L   + 
Sbjct: 2966 DHLREQQRELEAMRQRLLSAARLLTSFTSQAVDR-----TVNDWTSSNEKAVMSLLHTLE 3020

Query: 939  ELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH-KAT 997
            ELKS   R    ++++                        E Q     +L  +N+     
Sbjct: 3021 ELKSDLSRPTSSQKKMAA----------------------ELQFQFVDVLLKDNVSLTKA 3058

Query: 998  CETADRERAEMSTEISRLQSKIK-EMQQATSP 1028
              T  +E+ E+S  +S+L+  +K  +Q+  SP
Sbjct: 3059 LSTVTQEKLELSRAVSKLEKLLKHHLQKGCSP 3090



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 128/648 (19%), Positives = 261/648 (40%), Gaps = 104/648 (16%)

Query: 502  NKLQRNLENVLAEKFGDLDPSSAEFFLQEER------LTQMRNEYERQCRVLQDQVDELQ 555
            + L   LE ++ E+ GDL   S E     +R      +  +R +        Q+++  L+
Sbjct: 2485 SSLLERLEKIIREQ-GDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLR 2543

Query: 556  SELEEYRAQGRVLRLPLKNSPS------EEVEANSGGIEPEHGLGSEECNPLNMSIEAE- 608
            + L    A+G      L+          E+ +  +G ++       E+ N +   + AE 
Sbjct: 2544 TALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQ 2603

Query: 609  LVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQ 668
             V+  +K     D+C        + R   +QL  ++   ++    ++    ++ + L+  
Sbjct: 2604 TVVRDLKS----DLC--------ESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAA 2651

Query: 669  ISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE------------------ 710
            + +L++E    QG+   L+    E   RH + + Q    LEE                  
Sbjct: 2652 LQELESE----QGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVA 2707

Query: 711  ------EKTHLQEKLRLQHE------MELKARLTQAQASFEREREGLQSSAWTEEKVRGL 758
                   K +LQ++LR++H        + +++L++ Q     E+      +      R L
Sbjct: 2708 LKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLL 2767

Query: 759  TQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQR--ELQEGREKMETECNRRTSQIEA 816
            T++L Q  QE   + V + T     L ++L E+  R  +LQ   EK++ +      Q+EA
Sbjct: 2768 TEQLSQRTQE---ACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEA 2824

Query: 817  QFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDE---LTQECAEAQ 873
            + Q  C+ +    E     +    +  ++ L  Q+RE +   E E+++   L  E  ++ 
Sbjct: 2825 EAQKHCEALRREKE-----VSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSH 2879

Query: 874  ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLL 933
              LKE   R+        ++     + +++        R+  LQ   DL  + + QQ++ 
Sbjct: 2880 PRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTV- 2938

Query: 934  SDQILELKSSHKRELREREEV---LCQAGASEQLASQRLERLEMEHDQERQEMMSKLL-A 989
                        R+L  ++EV       G++ + A    + L  E  +E + M  +LL A
Sbjct: 2939 ------------RDLESKDEVPGSRLHLGSARRAAGSDADHLR-EQQRELEAMRQRLLSA 2985

Query: 990  MENIHKATCETADRERAE-MSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDG 1048
               +   T +  DR   +  S+    + S +  +++  S LS   S  + +  E      
Sbjct: 2986 ARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAE------ 3039

Query: 1049 ALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQ 1096
                 Q  + LL++N    +SL +A     +E ++++  +S+L++ L+
Sbjct: 3040 --LQFQFVDVLLKDN----VSLTKALSTVTQEKLELSRAVSKLEKLLK 3081



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 80/421 (19%), Positives = 164/421 (38%), Gaps = 60/421 (14%)

Query: 1718 ALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV--ASQEKVQNLEDTV 1775
            ++S       + + +  +    +  + Q  +   HQ  +L   L   + +      ED +
Sbjct: 2370 SISGRFQPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEI 2429

Query: 1776 QNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHN---- 1831
            Q+++L   + +         +  L Q V    ++ Q   G    P ++    G H+    
Sbjct: 2430 QDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLE 2489

Query: 1832 -------QQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1884
                   +Q  L    L+HL   ++  L  E + L+  ++ T  +   ++EK++ L + L
Sbjct: 2490 RLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQ---NQEKLQHLRTAL 2546

Query: 1885 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELE-TIHLEN 1943
                      S     ++QE         Q +++      KV Q   +  +L+ T+  E 
Sbjct: 2547 T---------SAEARGSQQEH--------QLRRQVELLAYKVEQEKCIAGDLQKTLSEEQ 2589

Query: 1944 EGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQ 2003
            E     Q  L  +   ++ L+S    S        + L +  C         ++Q+++LQ
Sbjct: 2590 EKANSVQKLLAAEQTVVRDLKSDLCESRQKS----EQLSRSLC---------EVQQEVLQ 2636

Query: 2004 AERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKE 2063
               +    + EL+    E  + QG    L + +EE  +   Q+     + L+E    L+ 
Sbjct: 2637 LRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLET 2696

Query: 2064 Q------LC-----KNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIAS 2112
            Q      LC     + T  D + K+L +E+++  +AL + ++R + +E +  L  EK  +
Sbjct: 2697 QRAQSSRLCVALKHEQTAKDNLQKELRIEHSR-CEAL-LAQERSQLSELQKDLAAEKSRT 2754

Query: 2113 L 2113
            L
Sbjct: 2755 L 2755


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score =  154 bits (388), Expect = 1e-36
 Identities = 388/1931 (20%), Positives = 774/1931 (40%), Gaps = 315/1931 (16%)

Query: 344  LALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMAS- 402
            L L++   VTK S  +A   S   E   L + ++ +  E+  LR  ++      SL+ S 
Sbjct: 1070 LILDHLPSVTKESSLRATQPS---ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126

Query: 403  EVDDHHAAIERRNEYNLRKLDEEY----KERIAALKN----ELRKEREQILQQAGKQRLE 454
             VD     +E   +  L  L EE     +E+I  L+     EL+  + Q     GK    
Sbjct: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186

Query: 455  LEQEIEKAKTEE-NYIRDRLALSL----------------KENS---------------- 481
            L  +++KA +EE +Y    L   L                KENS                
Sbjct: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246

Query: 482  -----------RLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFL 528
                        L N++ E   KL   +   +K+     + +  +FG+  L     EF  
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306

Query: 529  QEERLTQMRN---EYERQCRVLQD-QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANS 584
               ++T + +    ++ +   LQD +  +L+ +++E  +    L+  LK +  +  EA  
Sbjct: 1307 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKET-EQNYEAEI 1365

Query: 585  GGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKV----------- 633
              ++      SE   P ++ +++ ++ E   ++      C++  ++  +           
Sbjct: 1366 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425

Query: 634  --------RHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 685
                    + Y++QL+E V    K   +M      +T  L +     +N  +  Q  A  
Sbjct: 1426 TNIVKLLEKQYQEQLEEEVA---KVIVSMSIAFAQQTE-LSRISGGKENTASSKQAHAVC 1481

Query: 686  LKEAHHEATCRHEEEK------KQLQVKLEEEKTHLQEKLRLQHEMELKAR--------- 730
             +E H+    +  +++      + + VK +EE   L ++L  +H  E+            
Sbjct: 1482 QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG-EHGKEILLSNSDPHDIPE 1540

Query: 731  -----LTQAQASFERER---------EGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK 776
                 LT ++  F +++         + +  S+    +   L +E  +  +++L    ++
Sbjct: 1541 SKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE 1600

Query: 777  HTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK-VTERCESALQS 835
            H    E LR+  + + +R+ +E +E+++ E  R   Q+  +   D +  V+ER    L+ 
Sbjct: 1601 HQQATELLRQAHMRQMERQ-REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEE 1659

Query: 836  LEGRYRQELKDLQEQQREE------KSQWEFEKDELTQECAEAQELLKETLKR--EKTTS 887
            LE      LK L    RE+       S  + +     Q   E Q   ++ L R  E    
Sbjct: 1660 LEA-----LKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPP 1714

Query: 888  LVLTQEREMLEKTYKEHLNSM--VVERQQLLQD--------LEDLRNVSETQQSLL--SD 935
             +L+ ER  L+K     L  +  VV+    +++        + D  + S++  SL+  S+
Sbjct: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774

Query: 936  QILELKSS-HKRELREREEVLCQAGASEQLA----------------SQRLERLEM---E 975
                +KS  H+   R  +E +     S+                   SQRL R      E
Sbjct: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834

Query: 976  HDQERQEMMSKL-----LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLS 1030
             D E +E+M  +      A+E + +A  ET+ +      T+   ++   ++ Q+AT  L 
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK 1894

Query: 1031 MLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISR 1090
              +   + + EE    +     L + E +++   D     +R  ++      ++  E+  
Sbjct: 1895 CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLC 1954

Query: 1091 LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1150
               RLQ+LE          E  +        +  P ++Q   ++ E + +  +    + +
Sbjct: 1955 ASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP-VEQQLLQETEKLMKEKLEVQCQAE 2013

Query: 1151 EVRDLGSTGTSSVQRQEVKIE-ESEASVEGFSELENSEETRTESWELKNQISQLQEQLMM 1209
            +VRD        +Q+Q   +E + E  V  F ELE  +E  TE  +L+ Q   L++QL  
Sbjct: 2014 KVRD-------DLQKQVKALEIDVEEQVSRFIELE--QEKNTELMDLRQQNQALEKQLEK 2064

Query: 1210 LCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1269
            +    D   E+  D   +  V +++++ LE+  +  P+++ + E  +RE + L   L+  
Sbjct: 2065 MRKFLD---EQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121

Query: 1270 ETRYDEALENNKELTAEVFRLQDELKKME----EVTETFLSLEKSYDEVKIENEELNVLV 1325
              +  E L + ++L  ++    +E++K+E    E+ +  L  ++ +        EL+ L 
Sbjct: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELS-LE 2180

Query: 1326 LRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIE 1385
            ++LQ + + +             E  + NLE + +    Q  + LE     V+ +H  +E
Sbjct: 2181 VQLQAERDAIDRK----------EKEITNLEEQLE----QFREELENKNEEVQQLHMQLE 2226

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF 1445
              K+E+      T+L E  + +++            +  ++   +  + +  +  QD+H 
Sbjct: 2227 IQKKES-----TTRLQELEQENKLF-----------KDDMEKLGLAIKESDAMSTQDQHV 2270

Query: 1446 ---QHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEK----EEELKAMMHDL 1498
               +    I E E+E  +L E   KL++++ I    K +    E     E +++ +M D 
Sbjct: 2271 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2330

Query: 1499 QITCSEMQQKVELLRYESEKLQQENSILRNEIT----TLNEEDSISNLKLGTLNGSQEEM 1554
            +      ++++E L    EKLQQE + +  + +    +L+EE      +L  +   +  +
Sbjct: 2331 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2390

Query: 1555 WQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRL 1614
             Q+ ET  +E       +  +K  + E   K  QL  E   L ++  ++ EK+Q + +  
Sbjct: 2391 EQQVETANEE-------MTFMKNVLKETNFKMNQLTQELFSLKRER-ESVEKIQSIPENS 2442

Query: 1615 TEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQS---STLVSSLE--AELSEVKIQT 1669
                        N A++   ++K  L+  L    ++S    T   S E   + S + ++T
Sbjct: 2443 V-----------NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLET 2491

Query: 1670 HIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN----EKLLKEK--------- 1716
             ++Q E+ +   +LE  +   +  D+ +  Q  + +L       +K+++EK         
Sbjct: 2492 RLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQI 2551

Query: 1717 --EALSEELNSCVDKLAKSSLLEH-RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLED 1773
              EA+ E    C D    SS  E   I  + Q ++        L S + A   ++  LE 
Sbjct: 2552 QLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED------ELGSDISALTLRISELES 2605

Query: 1774 TVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQ 1833
             V  ++  +   K  + + ++     +++++ L K L+    K    E    P  +   +
Sbjct: 2606 QVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLK 2665

Query: 1834 KRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLN 1893
               +  +L H  + E+   + E E L+     TKAEL   +EK  +L+  LL K      
Sbjct: 2666 ---TTTELFH--SNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVK------ 2714

Query: 1894 PSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKL 1953
                    E    SL+++  Q +   + A  K+S    LE+E ET     E  + K+  +
Sbjct: 2715 --------ETNMTSLQKDLSQVRDHLAEAKEKLS---ILEKEDET-----EVQESKKACM 2758

Query: 1954 DEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMV-PREQFLQLQRQLLQAERINQHLQ 2012
             E L  ++  +S A+ +       L++      P +  +   +Q+    LQ+E  ++ + 
Sbjct: 2759 FEPL-PIKLSKSIASQTDG----TLKISSSNQTPQILVKNAGIQIN---LQSECSSEEVT 2810

Query: 2013 EELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLK----LVKRLLQEKVNQLKEQL-CK 2067
            E +   T +    Q      +  ME R I   + LK    +  +LL+E+   LK  + C 
Sbjct: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870

Query: 2068 NTKADAMVKDL 2078
             +K  + + +L
Sbjct: 2871 RSKEGSSIPEL 2881



 Score =  145 bits (367), Expect = 3e-34
 Identities = 384/1975 (19%), Positives = 799/1975 (40%), Gaps = 353/1975 (17%)

Query: 321  NSQEILKALDFSLDGNINLTELTLALENELL------VTKNSIHQAALASF---KAEI-- 369
            N Q+  +  D ++   + LTE +  L+ +          +NS H +  A     K +I  
Sbjct: 213  NLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT 272

Query: 370  -RHLLERVDQVVREKEKLRSD----------------LDKAEKLKSLMASEVDDHHAAIE 412
             +  LE  D ++ + +K + D                +++ +K+++    E+ +    IE
Sbjct: 273  HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIE 332

Query: 413  RRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDR 472
               E N + ++EE K     LK++L    +++L +  +Q ++  QEI+  K E    + +
Sbjct: 333  ---ELNTKIIEEEKKT--LELKDKLTTA-DKLLGELQEQIVQKNQEIKNMKLELTNSKQK 386

Query: 473  LALSLKENSRLEN---ELLENAEKLAEYE-NLTNKLQRNLENVLAEKFGDLDPSSAEFFL 528
               S +E  +L     EL +   K +++E ++  ++++  +  L +   +LD       +
Sbjct: 387  ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDE------M 440

Query: 529  QEERLTQMRNEYERQCRVLQDQVD-----ELQSELEEY------RAQGRVLRLPLK--NS 575
              +++ QM+ E  RQ     +++      E+++ L  Y        Q +++ + +   N 
Sbjct: 441  YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI 500

Query: 576  PSEEVEANSGGIEPEHGLGSEECNPLNMSIE---AELVIEQMKEQHHRDICCLRLELEDK 632
              ++  +    ++ E GL  EE   L   +E    EL   + + Q  R       E E K
Sbjct: 501  KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIA---EQESK 557

Query: 633  VRHYEKQLDET------VVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVL 686
            +    K L         +VS  ++++ ++ +HE E    + ++  L+ E      + AVL
Sbjct: 558  LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE------KNAVL 611

Query: 687  KEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQ 746
                       E  + QL    EEE + L+E L ++H + ++         ++++ +GLQ
Sbjct: 612  DRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQ 671

Query: 747  SSAWTEEKVRGLTQELE--QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKME 804
            +          ++Q++E  QF ++ L +   +  LE  +L+    +  Q  +    E+M 
Sbjct: 672  NE---------MSQKIETMQFEKDNLITKQNQLILEISKLK----DLQQSLVNSKSEEMT 718

Query: 805  TECNRRTSQIEAQFQSDCQKVT-ERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKD 863
             + N    +IE   Q + +K T E+    LQ       +++K+ +   +E+ +Q E E  
Sbjct: 719  LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778

Query: 864  ELTQECAEAQELLK--ETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLED 921
             L  E    +++LK    + +E+    + + + +  +  +++ +  ++ E + L Q    
Sbjct: 779  ILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ 838

Query: 922  LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 981
            L    E Q++  S      + ++ +EL  +EE  C     + L   +  + E+E+ + + 
Sbjct: 839  LNEEIEKQRNTFSFAEKNFEVNY-QEL--QEEYACLLKVKDDLEDSK-NKQELEY-KSKL 893

Query: 982  EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1041
            + +++ L ++ I+  T +       E  T ++      + +++ T+    L    +V   
Sbjct: 894  KALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTE---LMEKLEVTKR 950

Query: 1042 EEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
            E++E    LS L   EQL +++G++                 +  E+  L+Q  ++    
Sbjct: 951  EKLELSQRLSDL--SEQLKQKHGEISF---------------LNEEVKSLKQEKEQ---- 989

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1161
             V   C              + E  +  NR + V+    +  +S L D  V         
Sbjct: 990  -VSLRC-------------RELEIIINHNRAENVQSCDTQ--VSSLLDGVVTMTSRGAEG 1033

Query: 1162 SVQRQEVKI-EESEASVEGFSELEN---SEETRTESWELKNQISQLQEQLMMLCADCDRA 1217
            SV +      EES+  VE     EN    EE++ E   L +  S  +E  +       RA
Sbjct: 1034 SVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL-------RA 1086

Query: 1218 SEKKQD--LLFDVSVLKKKLKMLERIPEASP-KYKLLYEDVSRENDCLQEELRMMETRYD 1274
            ++  ++  L  +++VLK +   L    EA      L+Y   S   D ++E    ME   D
Sbjct: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVY---STHVDQVRE---YMENEKD 1140

Query: 1275 EALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEK 1334
            +AL + KE    +F  ++++K+++++ +  L   K+  E   E + L++L+ +LQ  + +
Sbjct: 1141 KALCSLKE--ELIFAQEEKIKELQKIHQLELQTMKT-QETGDEGKPLHLLIGKLQKAVSE 1197

Query: 1335 LQESVVQRCDCCLWEASLENLEIEPD-------GNILQLNQTLEECVPRVRSVHHVIEEC 1387
                 +Q     L E     L+ E +       G+ +  N+      P ++   + +++ 
Sbjct: 1198 ECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED-----PELQDYRYEVQDF 1252

Query: 1388 KQENQYL-------EGNTQLLEKVKAHEIAWLHGT----IQTHQERPRVQNQVILEENTT 1436
             QEN +        E N  L+ + +  +I W   T    ++  +E    +    L  ++ 
Sbjct: 1253 -QENMHTLLNKVTEEYNKLLVLQTRLSKI-WGQQTDGMKLEFGEENLPKEETEFLSIHSQ 1310

Query: 1437 LLGFQDKHFQHQATIAEL-ELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMM 1495
            +   +D    H++ ++ L +LEKTKL+E  ++L+  ++ L +Q       E E+  +A +
Sbjct: 1311 MTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLK-----ETEQNYEAEI 1365

Query: 1496 HDLQITCSEMQQ----------KVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLG 1545
            H LQ     + +           V +   ++++     S ++  I              G
Sbjct: 1366 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNID-------------G 1412

Query: 1546 TLNGSQE-EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604
            T+  S E  + ++T  VK      Q   E L+++++++ +       + TELS+ +    
Sbjct: 1413 TIEFSGEFGVKEETNIVKLLEKQYQ---EQLEEEVAKVIVSMSIAFAQQTELSRISG--- 1466

Query: 1605 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE 1664
             K    + +    +CQ+E+   N     ++Q  F   +  E   V+       L  EL E
Sbjct: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF---QTFETVDVKFKEEFKPLSKELGE 1523

Query: 1665 VKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELN 1724
                           K+ L      H  P+  D    IS  +   +K    ++++ +E++
Sbjct: 1524 HG-------------KEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS 1570

Query: 1725 -SCVDKLAKSSLLEHRIATMKQE--QKSWEHQSA------SLKSQLVASQEKVQNLEDTV 1775
             S +D   +  L E ++  M+QE  ++  EHQ A      +   Q+   +E  + L++ +
Sbjct: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630

Query: 1776 QNVNLQMSRMKS-DLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHN--- 1831
            + +N Q+++  S D      E+E +  E +   KQL  AG +    E+    +   N   
Sbjct: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNE 1690

Query: 1832 -----QQKRLSWDKLD--------HLMNEEQQLLWQENERL------------------- 1859
                 +++     +LD         +++ E+  L + N RL                   
Sbjct: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750

Query: 1860 ----------------QTMVQNTKAELT--------HSR---EKVRQLESNLLPKHQKHL 1892
                             +++  ++AE +        H+R   E +     + +P++  ++
Sbjct: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810

Query: 1893 NPSGTMNPTEQEKLSLK-----RECDQFQKE---------QSPANRKVSQMNSLEQELE- 1937
                T   TE  +  ++      E D   +E         Q+   + +  ++    +LE 
Sbjct: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870

Query: 1938 ----TIHLENEGLKKKQ-----VKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPM 1988
                   L  E  ++KQ     +K  E+L E  H  S A    +     ++L + +    
Sbjct: 1871 AKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA-----VELSKAEGVID 1925

Query: 1989 VPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLK 2048
               ++    +RQ+ +   I   L++EL   ++     +  Q+Q   + EER +   QK  
Sbjct: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ---IQEERELLSRQKEA 1982

Query: 2049 L-------VKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQ 2096
            +        ++LLQE    +KE+L    +A+ +  DL  +    +KALE+  + Q
Sbjct: 1983 MKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ----VKALEIDVEEQ 2033



 Score =  145 bits (367), Expect = 3e-34
 Identities = 392/1994 (19%), Positives = 789/1994 (39%), Gaps = 361/1994 (18%)

Query: 337  INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKL 396
            ++  E  + L++    +K+S+ +  +     E   L ++  Q+  E EK R+    AEK 
Sbjct: 797  VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN 856

Query: 397  KSLMASEVDDHHAAIERRN---EYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRL 453
              +   E+ + +A + +     E +  K + EYK ++ AL  EL       LQ+     +
Sbjct: 857  FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELH------LQRINPTTV 910

Query: 454  ELEQEI-EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENV- 511
            +++  + ++ KT        +A +L+    +E +  E  EKL   +    +L + L ++ 
Sbjct: 911  KMKSSVFDEDKTF-------VAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963

Query: 512  --LAEKFGDLDPSSAEFFLQEE--RLTQMRNEYERQCRVLQDQVDELQSE-LEEYRAQGR 566
              L +K G++       FL EE   L Q + +   +CR L+  ++  ++E ++    Q  
Sbjct: 964  EQLKQKHGEIS------FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVS 1017

Query: 567  VLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLR 626
             L   +    S   E +   +    G  S+      +S E   V E+ K++        +
Sbjct: 1018 SLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE--------Q 1069

Query: 627  LELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVL 686
            L L+    H      E+ +   +  EN K   + E + L+ + +DL+ ++   +   +++
Sbjct: 1070 LILD----HLPSVTKESSLRATQPSENDKL--QKELNVLKSEQNDLRLQMEAQRICLSLV 1123

Query: 687  KEAHHEATCRH-EEEKKQLQVKLEEEKTHLQEK----LRLQHEMELKARLTQAQASFERE 741
               H +    + E EK +    L+EE    QE+    L+  H++EL+   TQ     E  
Sbjct: 1124 YSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQ-----ETG 1178

Query: 742  REGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTL---------EKEELRKELLEKH 792
             EG        +  + +++E   F Q   + L E +T          +KE     + E  
Sbjct: 1179 DEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENE 1238

Query: 793  QRELQEGR-------EKMETECNR-------------RTSQIEAQFQSDCQKVT------ 826
              ELQ+ R       E M T  N+             R S+I  Q Q+D  K+       
Sbjct: 1239 DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ-QTDGMKLEFGEENL 1297

Query: 827  --ERCE--------SALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 876
              E  E        + L+ ++  ++ +L  LQ+    EK++ E +  EL    +  Q+ L
Sbjct: 1298 PKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDL---EKTKLEEQVQELESLISSLQQQL 1354

Query: 877  KETLKR----------------EKTT-------SLVLTQ---EREMLEKT-YKEHLNSMV 909
            KET +                 E T        S+V+T+   +R M   +  K++++  +
Sbjct: 1355 KETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTI 1414

Query: 910  VERQQ--LLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQ 967
                +  + ++   ++ + +  Q  L +++ ++  S      ++ E+   +G  E  AS 
Sbjct: 1415 EFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASS 1474

Query: 968  RLERLEMEHDQERQEMMSKLLAMENIHKATCETAD-----------RERAEMSTEISRLQ 1016
            +      + +Q     M   L+ + I   T ET D           +E  E   EI    
Sbjct: 1475 KQAHAVCQQEQHYFNEMK--LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSN 1532

Query: 1017 SKIKEMQQA-----TSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL------LEENGD 1065
            S   ++ ++     T    M       I  + +  + ++S +    QL      LE+   
Sbjct: 1533 SDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQ 1592

Query: 1066 VLLSLQRAHEQA--------VKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFG 1117
             L+   + H+QA        +++  +   +  +LQ+ +++L   L   S +D        
Sbjct: 1593 ELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE------ 1646

Query: 1118 NTAEQTEPFLQQN--RTKQVEGVTRRHVLSDLEDDEVRDL-GSTGTSSVQRQEVKIEESE 1174
            N   + E  L +     KQ+    R  +  +L +   +   G+     V+ Q  K +E +
Sbjct: 1647 NLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELD 1706

Query: 1175 ASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK 1234
               E        E    E + L+   ++L + L+ +          K     + ++ +  
Sbjct: 1707 RKPEDVPP----EILSNERYALQKANNRLLKILLEVV---------KTTAAVEETIGRHV 1753

Query: 1235 LKMLERIPEASPKYKLLYEDVSREN--DCLQEELRMMETRY-DEALENNKELTAEVFRLQ 1291
            L +L+R  ++     L++   +  +   C+ EE     TR  DE++ +          + 
Sbjct: 1754 LGILDRSSKSQSSASLIWRSEAEASVKSCVHEE----HTRVTDESIPSYSGSDMPRNDIN 1809

Query: 1292 DELKKMEEVTETFLSLEKSY---DEVKIENEELNVLVL-RLQGKIEKLQESVVQRCDCCL 1347
               K  EE TE    L +S     E+  ENEEL + +  RLQ  +EKL E++ +      
Sbjct: 1810 MWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISET----- 1864

Query: 1348 WEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAH 1407
              + LE+ ++     + +  +  +E    ++    + E   +E++  E   QL     A 
Sbjct: 1865 -SSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE---QL-----AV 1915

Query: 1408 EIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRK 1467
            E++   G I  + +   +  + I E+   +   + +       + ELE E+ ++QE    
Sbjct: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975

Query: 1468 LKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCS------EMQQKVELLRYESEK--- 1518
            L  +   +  +   +     +E  K M   L++ C       ++Q++V+ L  + E+   
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035

Query: 1519 ---------------LQQENSILRNEITT----LNEEDSISNLKLGTLNGSQEEMWQKTE 1559
                           L+Q+N  L  ++      L+E+      +        +++ Q+ +
Sbjct: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095

Query: 1560 TV-------KQENAAVQKMVENLKKQI---SELKIKNQQLDLENTELSQKNSQNQEKLQE 1609
             V       + +   V+++  +LK++    SEL +  +QL  +  E +++  + + +++E
Sbjct: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155

Query: 1610 LNQRLT--------------EMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSST-- 1653
            L Q L               E+  + + +    A++ +E+E  NL+E+LE+ + +     
Sbjct: 2156 LEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKN 2215

Query: 1654 -----LVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSY 1708
                 L   LE +  E   +   ++QEN L KD++EK+    +  D    Q +   +   
Sbjct: 2216 EEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQ-HVLFGK 2274

Query: 1709 NEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKV 1768
              ++++EKE   ++LN  V KL                      Q   + +     +EK 
Sbjct: 2275 FAQIIQEKEVEIDQLNEQVTKL---------------------QQQLKITTDNKVIEEKN 2313

Query: 1769 QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSG 1828
            + + D    +   MS  +   R  ++E E L + +  L ++L N G K+           
Sbjct: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT--------SMN 2365

Query: 1829 LHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKH 1888
             H+  +    D L H ++    ++  E   L+  V+    E+T  +  ++  E+N     
Sbjct: 2366 AHSLSEEA--DSLKHQLD----VVIAEKLALEQQVETANEEMTFMKNVLK--ETNF---- 2413

Query: 1889 QKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS----PANRKVSQMNSLEQELETI----- 1939
                     MN   QE  SLKRE +  +K QS      N  +  ++  + ELE +     
Sbjct: 2414 --------KMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDA 2465

Query: 1940 --HLEN--------EGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQ--QQACP 1987
               LEN        E  K   + L+ +L++++   S         A DL+L Q  +Q   
Sbjct: 2466 LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVS---------AKDLELTQCYKQIKD 2516

Query: 1988 MVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ----GNQEQLVTVMEERMIEV 2043
            M  + QF   + ++LQ + +N  LQ+ +E + +     Q      QE      + + I  
Sbjct: 2517 MQEQGQF---ETEMLQKKIVN--LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISS 2571

Query: 2044 EQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKN 2103
            E +   ++ L Q + ++L   +   T     + +L  +  ++  +L + +++ + AEK  
Sbjct: 2572 EPERTNIQNLNQLREDELGSDISALT---LRISELESQVVEMHTSLILEKEQVEIAEKNV 2628

Query: 2104 YLLEEKIASLSNIV 2117
               E+K+  L  ++
Sbjct: 2629 LEKEKKLLELQKLL 2642



 Score =  143 bits (361), Expect = 2e-33
 Identities = 353/1739 (20%), Positives = 717/1739 (41%), Gaps = 252/1739 (14%)

Query: 421  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 480
            ++D E +E +  + + L+   E++L+       E   ++E AK  +  +       ++E+
Sbjct: 1834 EIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTEL-------MRES 1882

Query: 481  SRLENELLENA---EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL---T 534
             R + E  E+    E+L E  +  ++ +  L   L++  G +D  + E  L E ++   T
Sbjct: 1883 FRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKT 1942

Query: 535  QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG 594
             + +  E++     +++ EL++E ++ + +  +L     +   E ++A +G +E +  L 
Sbjct: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEERELL-----SRQKEAMKAEAGPVEQQ--LL 1995

Query: 595  SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM 654
             E    +   +E +   E++++   + +  L +++E++V  + +   E      K  E M
Sbjct: 1996 QETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQE------KNTELM 2049

Query: 655  KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 714
              R +N+   LEKQ+  ++  + E     A+ +E        HE +  Q           
Sbjct: 2050 DLRQQNQA--LEKQLEKMRKFLDE----QAIDRE--------HERDVFQ----------- 2084

Query: 715  LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 774
             QE  +L+ ++++  R         RE E L +    +EK    ++ L    +EQL   +
Sbjct: 2085 -QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL--KEKTDKCSELL--LSKEQLQRDI 2139

Query: 775  EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 834
            ++   E E+L   + E  Q  L E R+       +    +E Q Q++   + +R E  + 
Sbjct: 2140 QERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAI-DRKEKEIT 2198

Query: 835  SLEGR---YRQELKDLQEQQREEKSQWEFEKDELT---QECAEAQELLKETLKRE----K 884
            +LE +   +R+EL++  E+ ++   Q E +K E T   QE  +  +L K+ +++     K
Sbjct: 2199 NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIK 2258

Query: 885  TTSLVLTQEREML---------EKTYK-EHLNSMVVERQQLLQDLEDLRNVSETQQSL-- 932
             +  + TQ++ +L         EK  + + LN  V + QQ L+   D + + E  + +  
Sbjct: 2259 ESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRD 2318

Query: 933  LSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM----------EHDQERQE 982
            L  QI  L S  +   R REE + Q     +   Q L  +            E     + 
Sbjct: 2319 LETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKH 2378

Query: 983  MMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE- 1041
             +  ++A +   +   ETA+ E   M   +     K+ ++ Q    L   +   + I   
Sbjct: 2379 QLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSI 2438

Query: 1042 EEVEGDGALSLLQQGEQLLEE--NGDVLLSLQ-RAHEQAVKENVKMATEISRLQQRLQKL 1098
             E   + A+  L + +  LE     D L SL+ + + ++ +EN K +  I  L+ RL +L
Sbjct: 2439 PENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGS--IINLETRLLQL 2496

Query: 1099 EPGLVMSSCLDEPATEFFGNTAEQTEP------FLQQ---NRTKQVEGVTRRHVLSDLED 1149
            E  +   S  D   T+ +    +  E        LQ+   N  K VE      ++S ++ 
Sbjct: 2497 ESTV---SAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL 2553

Query: 1150 DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMM 1209
            + V++       +   Q +  E    +++  ++L   +E  ++   L  +IS+L+ Q++ 
Sbjct: 2554 EAVQEYAKFCQDN---QTISSEPERTNIQNLNQLRE-DELGSDISALTLRISELESQVVE 2609

Query: 1210 LCADCDRASEKKQDLLFDVSVLKKKLKMLE--RIPEASPKYKLLYEDVSRENDC--LQEE 1265
            +        EK+Q  + + +VL+K+ K+LE  ++ E + K +   E      D   L+  
Sbjct: 2610 MHTSL--ILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTT 2667

Query: 1266 LRMMETRYDEALENNKELT--------AEVFRLQDELKKMEE---VTETFL-SLEKSYDE 1313
              +  +  +    N  E          AE+   +++ +K++E   V ET + SL+K   +
Sbjct: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727

Query: 1314 VKIE----NEELNVLVLRLQGKIEKLQESVVQRCD-CCLWEAS----LENLEIEPDGN-- 1362
            V+       E+L++L        EK  E+ VQ     C++E       +++  + DG   
Sbjct: 2728 VRDHLAEAKEKLSIL--------EKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLK 2779

Query: 1363 ILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQER 1422
            I   NQT +  V       ++  EC  E +  E  +Q  EK++  ++  LH       E 
Sbjct: 2780 ISSSNQTPQILVKNAGIQINLQSECSSE-EVTEIISQFTEKIE--KMQELHAAEILDMES 2836

Query: 1423 PRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVL 1482
              +     L+             +H   +  L+ E   L+ + + L+ +    + +   L
Sbjct: 2837 RHISETETLKR------------EHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPE---L 2881

Query: 1483 SHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1542
            +H +  +  +    D   + S+  Q + L   +   +  E     +E  T +    I  L
Sbjct: 2882 AHSDAYQTREICSSD---SGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGL 2938

Query: 1543 KLGTLN---------------GSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQ 1587
                 N               G    + Q +E   +E  A    + +LK  I+++++   
Sbjct: 2939 LRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQL--- 2995

Query: 1588 QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERC 1647
            Q + E  + SQ +    +   EL   L ++            LEER       + EL   
Sbjct: 2996 QREAEVYDSSQSHESFSDWRGELLLALQQVF-----------LEERSVLLAAFRTELTAL 3044

Query: 1648 KVQSST-LVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVL 1706
                +  L++ LE  + E  ++     +                 C   +D +  +S + 
Sbjct: 3045 GTTDAVGLLNCLEQRIQEQGVEYQAAME-----------------CLQKADRRSLLSEIQ 3087

Query: 1707 SYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQE 1766
            + + ++   K  L  E  S   +     LLE+ I   + +    + + +S+K +    QE
Sbjct: 3088 ALHAQMNGRKITLKREQES---EKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQE 3144

Query: 1767 KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHP 1826
            ++ + +  V  +  ++++ K +L  T + +    +E+ +   ++     K    E+    
Sbjct: 3145 QLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEV-----KDKTDEVHLLN 3199

Query: 1827 SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP 1886
              L ++QK+    +L   + +E+  L +  ER +  +++ K  L    +K R L+ NLL 
Sbjct: 3200 DTLASEQKKSR--ELQWALEKEKAKLGRSEERDKEELEDLKFSL--ESQKQRNLQLNLLL 3255

Query: 1887 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
            + QK L     +N ++Q+  S +   D    E+   N ++  +  LE E   I   +  L
Sbjct: 3256 EQQKQL-----LNESQQKIESQRMLYDAQLSEEQGRNLELQVL--LESEKVRIREMSSTL 3308

Query: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
             +++ +L  QL        +  P PS     L+ LQ+Q       E+  ++   L + E+
Sbjct: 3309 DRER-ELHAQLQSSDGTGQSRPPLPSEDL--LKELQKQL-----EEKHSRIVELLNETEK 3360

Query: 2007 IN----QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQL 2061
                  Q  Q+  ++R     T Q  QE   T  +++M E++ K++ ++R L+EK  Q+
Sbjct: 3361 YKLDSLQTRQQMEKDRQVHRKTLQTEQE-ANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3418



 Score =  134 bits (338), Expect = 7e-31
 Identities = 332/1570 (21%), Positives = 665/1570 (42%), Gaps = 193/1570 (12%)

Query: 339  LTELTLALEN--ELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAE-K 395
            +T L   LE   E L  KN   Q      + + +    R+ ++ +E +  + D++K    
Sbjct: 2197 ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2256

Query: 396  LKSLMASEVDDHH------AAIERRNEYNLRKLDEEYKERIAALK----NELRKEREQIL 445
            +K   A    D H      A I +  E  + +L+E+  +    LK    N++ +E+ +++
Sbjct: 2257 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI 2316

Query: 446  QQAGKQR--LELEQEIEKAKTEENY--IRDRLALSLKENSRLENELLENAEKLAEYENLT 501
            +    Q   L  +QE  K   EE    + + +    +E + +  +   NA  L+E     
Sbjct: 2317 RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEE---A 2373

Query: 502  NKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEY 561
            + L+  L+ V+AEK         +     E +T M+N  +     +     EL S   E 
Sbjct: 2374 DSLKHQLDVVIAEKLA----LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER 2429

Query: 562  RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRD 621
             +  ++  +P +NS +  ++  S   +PE  +   E      S+E +   +  +E     
Sbjct: 2430 ESVEKIQSIP-ENSVNVAIDHLSKD-KPELEVVLTE--DALKSLENQTYFKSFEENGKGS 2485

Query: 622  ICCLR---LELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE 678
            I  L    L+LE  V   + +L +    C K  ++M+++ + ET  L+K+I +L+ +I E
Sbjct: 2486 IINLETRLLQLESTVSAKDLELTQ----CYKQIKDMQEQGQFETEMLQKKIVNLQ-KIVE 2540

Query: 679  LQGQAAVLKEAHHEATCRHEEEKKQLQ-VKLEEEKTHLQEKLRLQHEMELKARLTQAQAS 737
             +  AA++ +   EA   + +  +  Q +  E E+T++Q   +L+ + EL          
Sbjct: 2541 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED-EL---------- 2589

Query: 738  FEREREGLQSSAWTEEKVRGLTQELEQFH-----QEQLTSLVEKHTLEKEELRKELL--- 789
                  G   SA T  ++  L  ++ + H     +++   + EK+ LEKE+   EL    
Sbjct: 2590 ------GSDISALTL-RISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL 2642

Query: 790  ---EKHQRELQEGREKMETECNRRTSQI-----EAQFQSDCQKVTERCESALQSLE-GRY 840
               EK QRE ++ R   + E  + T+++     E+ F ++ + +  R ES     E   Y
Sbjct: 2643 EGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEAL--RAESVATKAELASY 2700

Query: 841  RQELKDLQEQQR-EEKSQWEFEKD--ELTQECAEAQELLKETLKREKTTSLVLTQEREML 897
            +++ + LQE+   +E +    +KD  ++    AEA+E L   L++E  T +  +++  M 
Sbjct: 2701 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLS-ILEKEDETEVQESKKACMF 2759

Query: 898  EKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQ 957
            E    +   S+  +    L+    + + ++T Q L+ +  +++    +    E  E++ Q
Sbjct: 2760 EPLPIKLSKSIASQTDGTLK----ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQ 2815

Query: 958  AGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAE----MSTEIS 1013
                    ++++E+++  H  E       +L ME+ H +  ET  RE       +  E  
Sbjct: 2816 F-------TEKIEKMQELHAAE-------ILDMESRHISETETLKREHYVAVQLLKEECG 2861

Query: 1014 RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA 1073
             L++ I+ ++          +        E+    + S   QG  L    G  + S  R 
Sbjct: 2862 TLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2921

Query: 1074 HEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQ-TEPFLQQNRT 1132
             E++         +I  L + +     G+ + S  + P ++   ++ +Q +EP+L++ + 
Sbjct: 2922 -EESESATDSFPKKIKGLLRAVHN--EGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKA 2978

Query: 1133 KQVEGVTRRHVLSDLE---DDEVRDLGST--------GTSSVQRQEVKIEESEASVEGFS 1181
                  + + +++ ++   + EV D   +        G   +  Q+V +EE    +  F 
Sbjct: 2979 YINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAF- 3037

Query: 1182 ELENSEETRTESWELKNQISQ-LQEQLMMLCA--DCDRASEKKQDLLFDVSVLK-----K 1233
              E +    T++  L N + Q +QEQ +   A  +C + ++++  LL ++  L      +
Sbjct: 3038 RTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS-LLSEIQALHAQMNGR 3096

Query: 1234 KLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAE---VFRL 1290
            K+ +        P  +LL  ++ ++   + E    + +  D A E  ++L++E   V  L
Sbjct: 3097 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3156

Query: 1291 QDELKKMEEVTETFLS--------LEKSYDEVKIENEELNVLVLRLQGKIEKLQES--VV 1340
            + EL + +   ET L         LE    EVK + +E+++L   L  + +K +E    +
Sbjct: 3157 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3216

Query: 1341 QRCDCCLWEAS------LENLEIEPDGNI---LQLN-------QTLEECVPRVRSVHHVI 1384
            ++    L  +       LE+L+   +      LQLN       Q L E   ++ S   + 
Sbjct: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3276

Query: 1385 EECKQENQYLEGNTQLL---EKVKAHEIAW-------LHGTIQ----THQERPRVQNQVI 1430
            +    E Q      Q+L   EKV+  E++        LH  +Q    T Q RP + ++ +
Sbjct: 3277 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 3336

Query: 1431 LEENTTLLGFQDKHFQHQATIAEL--ELEKTKLQELTRKLKERVTILVKQKDVLSHGEKE 1488
            L+E    L  ++KH    + I EL  E EK KL  L  + +      V +K + +  E  
Sbjct: 3337 LKELQKQL--EEKH----SRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN 3390

Query: 1489 EELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRN-----EITTLNEEDSISNLK 1543
             E +  MH+LQ    ++Q+++E  R +  KL  E   L+      +   L  E+   + +
Sbjct: 3391 TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRR 3450

Query: 1544 LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQN 1603
            +   N ++   W  T   +  N  +Q+ +E   K+ +  K+   +++   T  + +    
Sbjct: 3451 ILYQNLNEPTTWSLTSD-RTRNWVLQQKIEGETKESNYAKL--IEMNGGGTGCNHELEMI 3507

Query: 1604 QEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-LKEELERCKVQSSTLVSSLEAEL 1662
            ++KLQ +  +L ++L QK  E      E  + E F  ++E ++   +Q   L      E 
Sbjct: 3508 RQKLQCVASKL-QVLPQKASE--RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEP 3564

Query: 1663 SEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEE 1722
            S V   T        LL+   E    + +  +  +  + +  V+   E++   ++  +  
Sbjct: 3565 SLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNM--VMKLEEQIRWYRQTGAGR 3622

Query: 1723 LNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQM 1782
             NS    L   + +E  IA+   E++ W  +  +L+  L  ++ +V  L+  ++N +L  
Sbjct: 3623 DNSSRFSLNGGANIEAIIAS---EKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQ 3679

Query: 1783 SRMKSDLRVT 1792
            +       VT
Sbjct: 3680 TLSPDSEHVT 3689



 Score =  121 bits (303), Expect = 8e-27
 Identities = 293/1432 (20%), Positives = 591/1432 (41%), Gaps = 231/1432 (16%)

Query: 789  LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848
            LE  + EL   + ++E E NR   ++   + ++  +  +  E+A++  +G   Q   +LQ
Sbjct: 157  LEMMESELAGKQHEIE-ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ 215

Query: 849  EQQREEKSQWEFEKDELTQECAEAQELLK-----ETLKR--EKTTSLVLTQEREMLEKTY 901
            + +R EK +   E  ELT++  + Q   +     ETL+     +T+  L Q ++ +  T+
Sbjct: 216  QARR-EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI-LTH 273

Query: 902  KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQI--------LELKSSHKRELREREE 953
            ++ L     E+  LL+D +  +     Q S L ++I         ++++S+K E++E+E 
Sbjct: 274  QQQLE----EQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKET 329

Query: 954  VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1013
            ++           + L    +E +++  E+  KL            TAD+   E+  +I 
Sbjct: 330  II-----------EELNTKIIEEEKKTLELKDKL-----------TTADKLLGELQEQIV 367

Query: 1014 RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA 1073
            +   +IK M+             ++   ++ E        Q  E++ +  G V    +R 
Sbjct: 368  QKNQEIKNMK------------LELTNSKQKE-------RQSSEEIKQLMGTVEELQKRN 408

Query: 1074 HEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTK 1133
            H+ +  E   +       Q++L++L   L           E +G    Q +  L +    
Sbjct: 409  HKDSQFETDIVQRMEQETQRKLEQLRAEL----------DEMYGQQIVQMKQELIRQHMA 458

Query: 1134 QVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTES 1193
            Q+E +  RH     + +    L S    +V   ++K+     +           E   + 
Sbjct: 459  QMEEMKTRH-----KGEMENALRSYSNITVNEDQIKLMNVAIN-----------ELNIKL 502

Query: 1194 WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL-KMLERIPEASPKYKLLY 1252
             +  +Q  +L+E+L ++  +      + +DL+ ++S  ++++ +  + I E   K    +
Sbjct: 503  QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH 562

Query: 1253 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL-SLEKSY 1311
            + +S   D   E +   E+R +  L++  E+T    +L+   K+   V +    S E   
Sbjct: 563  KSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622

Query: 1312 DEVKIE-----NEELNVLVLRLQGK----IEKLQESV----VQRCDCCLWEAS--LENLE 1356
            + ++ +      EEL+ L   L+ +    IEKL++++     Q+ D    E S  +E ++
Sbjct: 623  ERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQ 682

Query: 1357 IEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLE----KVKAHEIAWL 1412
             E D  I + NQ + E + +++ +   +   K E   L+ N    E    + +  E   L
Sbjct: 683  FEKDNLITKQNQLILE-ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL 741

Query: 1413 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTR-----K 1467
               +Q  Q +  +  + + E+   L   Q+K  Q +A  + L+ EK  L+++ +      
Sbjct: 742  EQEVQELQLKTELLEKQMKEKENDL---QEKFAQLEAENSILKDEKKTLEDMLKIHTPVS 798

Query: 1468 LKERVTIL--VKQKDVLSHGEKE-EELKAMMHDLQITCSEMQQKVELLR----------- 1513
             +ER+  L  +K K   S  EKE E L     DL+  C ++ +++E  R           
Sbjct: 799  QEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFE 858

Query: 1514 YESEKLQQENSILRNEITTLNEEDSISNL----KLGTLNGSQEEMWQKTETVKQEN---- 1565
               ++LQ+E + L      L +  +   L    KL  LN           TVK ++    
Sbjct: 859  VNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFD 918

Query: 1566 ------AAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQR---LTE 1616
                  A   +M E ++K  +EL  K +    E  ELSQ+ S   E+L++ +     L E
Sbjct: 919  EDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNE 978

Query: 1617 MLCQKEKEPGNSALEEREQE---KFNLKEELERCKVQSSTL------VSSLEAELSEVKI 1667
             +   ++E    +L  RE E     N  E ++ C  Q S+L      ++S  AE S  K+
Sbjct: 979  EVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKV 1038

Query: 1668 QTHIVQQENHLLKDEL--------EKMKQ----LHRCPDLSDFQQKISSVLSYNEKLLKE 1715
                 ++   +++D++        E+ KQ    L   P ++      ++  S N+KL KE
Sbjct: 1039 NKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKE 1098

Query: 1716 KEALSEELNSC-----VDKLAKSSLLEHRIATMKQEQKSWEHQS-ASLKSQLV-ASQEKV 1768
               L  E N         ++  S +    +  +++  ++ + ++  SLK +L+ A +EK+
Sbjct: 1099 LNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKI 1158

Query: 1769 QNLEDTVQNVNLQMSRMKSD----------LRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1818
            + L+   Q   L++  MK+           L + + +K A+ +E     + L +  G+ +
Sbjct: 1159 KELQKIHQ---LELQTMKTQETGDEGKPLHLLIGKLQK-AVSEECSYFLQTLCSVLGEYY 1214

Query: 1819 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVR 1878
             P +      ++ + K  S D +    + E Q    E +  Q  +     ++T    K+ 
Sbjct: 1215 TPALKCE---VNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL 1271

Query: 1879 QLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELET 1938
             L++ L     +          T+  KL    E     KE++      SQM +LE +++ 
Sbjct: 1272 VLQTRLSKIWGQQ---------TDGMKLEFGEE--NLPKEETEFLSIHSQMTNLE-DIDV 1319

Query: 1939 IHLENEGLKK--KQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQ 1996
             H       +  ++ KL+EQ+ E++ L S+            Q L++           LQ
Sbjct: 1320 NHKSKLSSLQDLEKTKLEEQVQELESLISSLQ----------QQLKETEQNYEAEIHCLQ 1369

Query: 1997 LQRQLLQAERINQHLQEE----LENRTSETNTPQGNQEQLV--TVMEERMIEVEQKLKLV 2050
             + Q +    +   L  +     E+    T  P    ++ +  T+       V+++  +V
Sbjct: 1370 KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIV 1429

Query: 2051 KRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKK 2102
            K L ++   QL+E++ K      ++  + +  AQ  +   ++  ++ TA  K
Sbjct: 1430 KLLEKQYQEQLEEEVAK------VIVSMSIAFAQQTELSRISGGKENTASSK 1475



 Score =  116 bits (291), Expect = 2e-25
 Identities = 282/1386 (20%), Positives = 580/1386 (41%), Gaps = 245/1386 (17%)

Query: 752  EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 811
            ++K+     +L QF Q +  S  +  + ++++ RK    KH           +++CN   
Sbjct: 7    QKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN--- 63

Query: 812  SQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT--QEC 869
               E    S     ++R ES +   E    + L   +    E+    E E +  T   +C
Sbjct: 64   ---EMYINS-----SQRVESTVIP-ESTIMRTLHSGEITSHEQGFSVELESEISTTADDC 114

Query: 870  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKE--------HLNSMVVERQQLLQDLED 921
            +         ++  K T+L L +E   ++ +Y E        HL  M  E      ++E+
Sbjct: 115  SSEVNGCSFVMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEE 173

Query: 922  LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 981
            L    E  +     + L+     +  +++R+ ++ Q  A+ Q A            +E+ 
Sbjct: 174  LNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR-----------REKD 222

Query: 982  EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1041
            E M + L +         T   ++ ++  +  +    ++    +++   +LQ+  Q++  
Sbjct: 223  ETMREFLEL---------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273

Query: 1042 EEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
            ++         L++ + LLE+             Q  KE+  M  +IS LQ++++     
Sbjct: 274  QQ--------QLEEQDHLLED------------YQKKKEDFTM--QISFLQEKIK----- 306

Query: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1161
             V     D+          ++ E  +++  TK +E   +   L D      + LG     
Sbjct: 307  -VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ 365

Query: 1162 SVQR-QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1220
             VQ+ QE+K  + E +     E ++SEE +    +L   + +LQ++              
Sbjct: 366  IVQKNQEIKNMKLELTNSKQKERQSSEEIK----QLMGTVEELQKR-------------N 408

Query: 1221 KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENN 1280
             +D  F+  ++++                 + ++  R+ + L+ EL  M  +  + ++  
Sbjct: 409  HKDSQFETDIVQR-----------------MEQETQRKLEQLRAELDEMYGQ--QIVQMK 449

Query: 1281 KELTAEVFRLQDELK-----KMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQ---GKI 1332
            +EL  +     +E+K     +ME    ++ ++  + D++K+ N  +N L ++LQ    + 
Sbjct: 450  QELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509

Query: 1333 EKLQESV-VQRCDCCLWEASLENLEIE---PDGNILQLNQTLEECVPRVRSVH---HVIE 1385
            EKL+E + +   + C  +  LE+L  E       I +  QT+ E   ++   H     +E
Sbjct: 510  EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569

Query: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF 1445
            + K E      + + LE     E+              +++ +++ +E   +L   D+  
Sbjct: 570  DLKAEIVSASESRKELELKHEAEVT-----------NYKIKLEMLEKEKNAVL---DRMA 615

Query: 1446 QHQATIAELELEKTKL----QELTRKLKERVTI-----LVKQKDVLSHGEKEEELKAMMH 1496
            + Q   AELE  +T+L    +E   KLKE + I     + K KD L    K++     + 
Sbjct: 616  ESQE--AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ-----ID 668

Query: 1497 DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-EDSISNLKLGTLNGSQEEMW 1555
             LQ   +EM QK+E +++E + L  + + L  EI+ L + + S+ N K   +     E+ 
Sbjct: 669  GLQ---NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ 725

Query: 1556 QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLT 1615
            ++ E ++QE    +K    L++++ EL++K + L+    ++ +K +  QEK  +L     
Sbjct: 726  KEIEILRQE----EKEKGTLEQEVQELQLKTELLE---KQMKEKENDLQEKFAQL----- 773

Query: 1616 EMLCQKEKEPGNSALEEREQEKFNLKEELE-RCKVQSSTLVSSLEAELSEVKIQTHIVQQ 1674
                    E  NS L++   EK  L++ L+    V     +  L++  S  K +  + ++
Sbjct: 774  --------EAENSILKD---EKKTLEDMLKIHTPVSQEERLIFLDSIKS--KSKDSVWEK 820

Query: 1675 ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1734
            E  +L +E E +KQ  +C  L++  +K  +  S+ EK  +      +E  +C+ K+ K  
Sbjct: 821  EIEILIEENEDLKQ--QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKV-KDD 877

Query: 1735 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSD------ 1788
            L           + S   Q    KS+L A  E++      +Q +N    +MKS       
Sbjct: 878  L-----------EDSKNKQELEYKSKLKALNEELH-----LQRINPTTVKMKSSVFDEDK 921

Query: 1789 --LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN 1846
              +  T +  E ++++   L ++L+    K    E++   S L  Q K+   +     +N
Sbjct: 922  TFVAETLEMGEVVEKDTTELMEKLEVT--KREKLELSQRLSDLSEQLKQKHGE--ISFLN 977

Query: 1847 EEQQLLWQENERLQTMVQNTKAELTHSR-EKVRQLESNLLPKHQKHLNPSGTMNPTEQEK 1905
            EE + L QE E++    +  +  + H+R E V+  ++ +       L+   TM     E 
Sbjct: 978  EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV----SSLLDGVVTMTSRGAEG 1033

Query: 1906 LSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDE--QLMEMQHL 1963
             S+ +    F +E      K+   + +  E  T+    E  K++Q+ LD    + +   L
Sbjct: 1034 -SVSKVNKSFGEES-----KIMVEDKVSFENMTV---GEESKQEQLILDHLPSVTKESSL 1084

Query: 1964 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2023
            R+T          +L +L+ +   +  + +  ++   L+ +  ++Q ++E +EN      
Sbjct: 1085 RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQ-VREYMENE----- 1138

Query: 2024 TPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENA 2083
                  + L ++ EE +   E+K+K +     +K++QL+ Q  K  +     K L++   
Sbjct: 1139 ----KDKALCSLKEELIFAQEEKIKEL-----QKIHQLELQTMKTQETGDEGKPLHLLIG 1189

Query: 2084 QLLKAL 2089
            +L KA+
Sbjct: 1190 KLQKAV 1195



 Score =  113 bits (283), Expect = 2e-24
 Identities = 316/1689 (18%), Positives = 682/1689 (40%), Gaps = 287/1689 (16%)

Query: 483  LENELLENAEKLAEYENLTNKLQRNLE--NVLAEKFGDLDPSSAEFFLQEE--RLTQMRN 538
            LE+E+   A+  +   N  + + R  +  N+L E+   +D S +E   Q+    L  M +
Sbjct: 103  LESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMES 162

Query: 539  EYERQCRVLQDQVDELQSELEEYRA--------------------QGRVLRLP--LKNSP 576
            E   +    Q +++EL  ELEE R                      G + +L   L+ + 
Sbjct: 163  ELAGK----QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR 218

Query: 577  SEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHY 636
             E+ E     +E      +E+   L +  +     E ++   H       L+ + ++  +
Sbjct: 219  REKDETMREFLEL-----TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273

Query: 637  EKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEI----------------AELQ 680
            ++QL+E        Q+++ + ++ +      QIS L+ +I                 E+Q
Sbjct: 274  QQQLEE--------QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325

Query: 681  GQAAVLKEAHHEATCRHEEEKKQLQVK-----LEEEKTHLQEKL--RLQHEMELKARLTQ 733
             +  +++E + +     EEEKK L++K      ++    LQE++  + Q    +K  LT 
Sbjct: 326  EKETIIEELNTKII---EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN 382

Query: 734  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 793
            ++    +  E ++    T E+++    +  QF  + +  + ++   + E+LR EL E + 
Sbjct: 383  SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442

Query: 794  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYR---QELKDLQEQ 850
            +++ + ++++  +   +  +++ + + + +    R  S +   E + +     + +L  +
Sbjct: 443  QQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL-RSYSNITVNEDQIKLMNVAINELNIK 501

Query: 851  QREEKSQWEFEKDE----LTQECAEAQEL---------LKETLKREKTTSLVLTQEREML 897
             ++  SQ E  K+E    L ++CA  ++L          +E ++R + T   + ++   L
Sbjct: 502  LQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQT---IAEQESKL 558

Query: 898  EKTYK-----EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRERE 952
             + +K     E L + +V   +  ++LE       T   +  + + + K++    + E +
Sbjct: 559  NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ 618

Query: 953  EVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEI 1012
            E   +   ++ L S   E  +++ D E +  ++     +N+     +  D  + EMS +I
Sbjct: 619  EAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKI 678

Query: 1013 SRLQ-----------------SKIKEMQQA---------TSPLSMLQSGCQVIGEEEVEG 1046
              +Q                 SK+K++QQ+         T  ++ LQ   +++ +EE E 
Sbjct: 679  ETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE- 737

Query: 1047 DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN-VKMATEISRLQQRLQKLEPGLVMS 1105
                  L+Q  Q L+   ++L    +  E  ++E   ++  E S L+   + LE  L + 
Sbjct: 738  ---KGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794

Query: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
            + + +          E+   FL   ++K  + V  + +   +E++E           +++
Sbjct: 795  TPVSQ----------EERLIFLDSIKSKSKDSVWEKEIEILIEENE----------DLKQ 834

Query: 1166 QEVKI-EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDL 1224
            Q +++ EE E     FS  E       +++E+  Q  Q +   ++   D    S+ KQ+L
Sbjct: 835  QCIQLNEEIEKQRNTFSFAE-------KNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887

Query: 1225 LFDVSVLKKKLKM------LERIPEASPKYKLLYEDVSRENDCLQEELRMME------TR 1272
             +     K KLK       L+RI   + K K    D   +   + E L M E      T 
Sbjct: 888  EY-----KSKLKALNEELHLQRINPTTVKMKSSVFD--EDKTFVAETLEMGEVVEKDTTE 940

Query: 1273 YDEALENNKELTAEVF-RLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGK 1331
              E LE  K    E+  RL D  +++++       L +    +K E E++++    L+  
Sbjct: 941  LMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEII 1000

Query: 1332 IEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1391
            I   +   VQ CD          +    DG +   ++  E  V +V        +   E+
Sbjct: 1001 INHNRAENVQSCD--------TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052

Query: 1392 QYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRV----QNQVILEENTTLLGFQ-DKHFQ 1446
            +    N  + E+ K  ++   H    T +   R     +N  + +E   L   Q D   Q
Sbjct: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQ 1112

Query: 1447 HQATIAELEL----EKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITC 1502
             +A    L L       +++E     K++    +K++ + +  EK +EL+  +H L++  
Sbjct: 1113 MEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQ-KIHQLELQT 1171

Query: 1503 SEMQQ------KVELLRYESEKLQQE-----------------NSILRNEITTLNEEDSI 1539
             + Q+       + LL  + +K   E                    L+ E+   ++E+S 
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSG 1231

Query: 1540 SNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK----QISELKIKNQQLDLENTE 1595
              +        Q+  ++  +  +  +  + K+ E   K    Q    KI  QQ D    E
Sbjct: 1232 DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLE 1291

Query: 1596 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQS---- 1651
              ++N   +E         TE L    +      ++   + K +  ++LE+ K++     
Sbjct: 1292 FGEENLPKEE---------TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQE 1342

Query: 1652 -STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDL---------SDFQ-- 1699
              +L+SSL+ +L E +      + E H L+  L+ + +    P L         SD Q  
Sbjct: 1343 LESLISSLQQQLKETE---QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRT 1399

Query: 1700 --------QKISSVLSYNEKL-LKEK----EALSEELNSCVDKLAKSSLLEHRIATMKQE 1746
                    + I   + ++ +  +KE+    + L ++    +++     ++   IA  +Q 
Sbjct: 1400 MYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459

Query: 1747 QKS-----WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQ 1801
            + S      E+ ++S ++  V  QE+    E       +++S+ +   +  +      K+
Sbjct: 1460 ELSRISGGKENTASSKQAHAVCQQEQHYFNE-------MKLSQDQIGFQTFETVDVKFKE 1512

Query: 1802 EVMSLHKQLQNAGGKSWAPEIATHPSGLHN--QQKRLSWDKLDHLMNEEQQLLWQE--NE 1857
            E   L K+L   G      EI    S  H+  + K       + + ++++  + ++  ++
Sbjct: 1513 EFKPLSKELGEHG-----KEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHD 1567

Query: 1858 RLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE-CDQFQ 1916
             +     +   +L  + E++  +   L+ ++Q+H   +  +      ++  +RE  +Q Q
Sbjct: 1568 EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ 1627

Query: 1917 KEQSPANRKVSQMNSLE-----QELETIHLEN-EGLKKKQVKLDEQLMEMQHLRSTATPS 1970
            +E    NR+++Q +S++      E E + LE  E LK+  +   E+L       ST T +
Sbjct: 1628 EEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687

Query: 1971 PSPHAWDLQ 1979
             + +  +++
Sbjct: 1688 GNENQGEVE 1696



 Score =  103 bits (257), Expect = 2e-21
 Identities = 246/1240 (19%), Positives = 509/1240 (41%), Gaps = 178/1240 (14%)

Query: 977  DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGC 1036
            D+ERQ+ +    A     +     +D +      +  R  S  K    A   L++ QS C
Sbjct: 3    DEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQC 62

Query: 1037 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQR----AHEQAVKENVKMATEISRLQ 1092
              +          ++  Q+ E  +     ++ +L      +HEQ    +V++ +EIS   
Sbjct: 63   NEM---------YINSSQRVESTVIPESTIMRTLHSGEITSHEQGF--SVELESEISTTA 111

Query: 1093 QRLQKLEPGLVMSSCLDEPAT----EFFGNTAEQTEPFLQQNRTK----QVEGVTRRHVL 1144
                    G        +P      E FG     +E   Q + T     + E   ++H +
Sbjct: 112  DDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI 171

Query: 1145 SDL--EDDEVR-DLGSTGTSSVQRQEVKIEESEASVEGFSE-----LENSEETRTESWEL 1196
             +L  E +E+R   G+ G   +Q  E  I++ +  +   +          +ET  E  EL
Sbjct: 172  EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLEL 231

Query: 1197 KNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL----KMLERIPEASPKYKLLY 1252
              Q  +LQ Q   L A     +        D+   K+++    + LE        Y+   
Sbjct: 232  TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKK 291

Query: 1253 EDVSRENDCLQEELRMMETRYDEALEN-NKELTAEVFRLQDELKKMEEVTETFLSLEKSY 1311
            ED + +   LQE++++ E   D+ +EN NKE       +Q++   +EE+    +  EK  
Sbjct: 292  EDFTMQISFLQEKIKVYEMEQDKKVENSNKE------EIQEKETIIEELNTKIIEEEKKT 345

Query: 1312 DEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLE 1371
             E+K +    + L       + +LQE +VQ+         ++N+++E   +  +  Q+ E
Sbjct: 346  LELKDKLTTADKL-------LGELQEQIVQK------NQEIKNMKLELTNSKQKERQSSE 392

Query: 1372 ECVPRVRSVHHVIEECKQEN-----------QYLEGNTQL-LEKVKAHEIAWLHGT--IQ 1417
            E    ++ +   +EE ++ N           Q +E  TQ  LE+++A E+  ++G   +Q
Sbjct: 393  E----IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRA-ELDEMYGQQIVQ 447

Query: 1418 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIA----ELELEKTKLQELTRKLKERVT 1473
              QE  R     + E  T   G  +   +  + I     +++L    + EL  KL++  +
Sbjct: 448  MKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507

Query: 1474 ILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL 1533
                QK+ L     +EEL  ++ +      +++  VE L +  E++Q+    +  + + L
Sbjct: 508  ----QKEKL-----KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558

Query: 1534 NEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLEN 1593
            NE    ++  L T+   + E+   +E+ K+     +  V N K       IK + L+ E 
Sbjct: 559  NE----AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYK-------IKLEMLEKEK 607

Query: 1594 TELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELE-------- 1645
              +  + +++QE   EL +  T++L               E+E   LKE+LE        
Sbjct: 608  NAVLDRMAESQEA--ELERLRTQLLFS------------HEEELSKLKEDLEIEHRINIE 653

Query: 1646 ----RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD-----ELEKMKQLHRCPDLS 1696
                   +     +  L+ E+S+ KI+T   +++N + K      E+ K+K L +    S
Sbjct: 654  KLKDNLGIHYKQQIDGLQNEMSQ-KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS 712

Query: 1697 DFQQKISSV--LSYNEKLLKEKEALSEELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQ 1753
              ++    +  L    ++L+++E     L   V +L  K+ LLE +   MK+++   + +
Sbjct: 713  KSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQ---MKEKENDLQEK 769

Query: 1754 SASLKSQLVASQEKVQNLEDTV----------QNVNLQMSRMKS-------DLRVTQQEK 1796
             A L+++    +++ + LED +          + + L   + KS       ++ +  +E 
Sbjct: 770  FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEEN 829

Query: 1797 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKL-DHLMNEEQQLLWQE 1855
            E LKQ+ + L+++++         E     +    Q++     K+ D L + + +   + 
Sbjct: 830  EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEY 889

Query: 1856 NERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNP-TEQEKLSLKRECDQ 1914
              +L+ +  N +  L        +++S++  + +  +  +  M    E++   L  + + 
Sbjct: 890  KSKLKAL--NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEV 947

Query: 1915 FQKEQSPANRKVSQMN-SLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1973
             ++E+   ++++S ++  L+Q+   I   NE +K  + + ++  +  + L      +   
Sbjct: 948  TKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN--- 1004

Query: 1974 HAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE----LENRTSETNTPQG-- 2027
             A ++Q    Q   ++     +  +       ++N+   EE    +E++ S  N   G  
Sbjct: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064

Query: 2028 -NQEQLV-----TVMEERMIEVEQ-----KLKLVKRLLQEKVNQLKEQLCKNTKADAMVK 2076
              QEQL+     +V +E  +   Q     KL+    +L+ + N L+ Q+       ++V 
Sbjct: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124

Query: 2077 DLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNI 2116
              +V+  +     E  +      E+  +  EEKI  L  I
Sbjct: 1125 STHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI 1164



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 330/1690 (19%), Positives = 682/1690 (40%), Gaps = 237/1690 (14%)

Query: 31   EELTDLCH--MLSLEEVAPVLQQTLLQ-DNLLGRVHFDQFKEALILILSRTLSNEEHF-- 85
            +E TD C   +LS E++   +Q+   + + L  RV   + ++AL++       + +HF  
Sbjct: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR--ELEQALLV------EDRKHFGA 2170

Query: 86   --QEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDC 143
               +P+ SLE Q +  R       + +   +E +E+F E   +E  +EE +  H+   + 
Sbjct: 2171 VEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE--ELENKNEEVQQLHMQL-EI 2227

Query: 144  SEHWKTQRSEEYEAEGQLRFWNPDDL----NASQSGSSPPQDWIEEKLQEVCEDLGITRD 199
             +   T R +E E E +L   + + L      S + S+  Q  +  K  ++ ++  +  D
Sbjct: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEID 2287

Query: 200  GHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSAST 259
              LN +  V+  +Q      D +++EE  + L  D    +E     L  + + +  +   
Sbjct: 2288 -QLNEQ--VTKLQQQLKITTDNKVIEEK-NELIRDLETQIE----CLMSDQECVKRNREE 2339

Query: 260  PYRQLKRHLS--MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGH-ASVERILDTWQE 316
               QL   +    Q     G++T+ ++   S     +   LD  +    ++E+ ++T  E
Sbjct: 2340 EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE 2399

Query: 317  EGIENSQEILKALDFSLDGNINLTELTLALENE-------LLVTKNSIHQAALASFKAEI 369
            E +   + +LK  +F ++    LT+   +L+ E         + +NS++ A         
Sbjct: 2400 E-MTFMKNVLKETNFKMN---QLTQELFSLKRERESVEKIQSIPENSVNVA--------- 2446

Query: 370  RHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE---EY 426
                  +D + ++K +L   L + + LKSL   E   +  + E   + ++  L+    + 
Sbjct: 2447 ------IDHLSKDKPELEVVLTE-DALKSL---ENQTYFKSFEENGKGSIINLETRLLQL 2496

Query: 427  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
            +  ++A   EL +  +QI     + + E E   +K    +  + +++A +L    +LE  
Sbjct: 2497 ESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE-A 2555

Query: 487  LLENAEKLAEYENLTNKLQR-NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCR 545
            + E A+   + + ++++ +R N++N+   +  +L    +   L+   L     E      
Sbjct: 2556 VQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI 2615

Query: 546  VLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSI 605
            + ++QV+  +  + E            K     E++    G E +     ++ +P ++ +
Sbjct: 2616 LEKEQVEIAEKNVLE------------KEKKLLELQKLLEGNEKKQREKEKKRSPQDVEV 2663

Query: 606  ---EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 662
                 EL     +     ++  LR E        + +L       +K QE +  +  N T
Sbjct: 2664 LKTTTELFHSNEESGFFNELEALRAESVAT----KAELASYKEKAEKLQEELLVKETNMT 2719

Query: 663  HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ 722
             +L+K +S +++ +AE + + ++L++   E     +E KK      E     L + +  Q
Sbjct: 2720 -SLQKDLSQVRDHLAEAKEKLSILEK---EDETEVQESKKACM--FEPLPIKLSKSIASQ 2773

Query: 723  HEMELKARLTQAQASFEREREG----LQSSAWTEEKVRGLTQ------ELEQFHQEQLTS 772
             +  LK   +        +  G    LQS   +EE    ++Q      ++++ H  ++  
Sbjct: 2774 TDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILD 2833

Query: 773  LVEKHTLEKEELRKELLEKHQRELQE-GREKMETEC--NRRTSQIEAQFQSDCQKVTERC 829
            +  +H  E E L++E     Q   +E G  K   +C  ++  S I     SD  +  E C
Sbjct: 2834 MESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREIC 2893

Query: 830  ESALQSLEGR----YRQELKDLQEQQREEKSQW---EFEKD------ELTQECAEAQELL 876
             S   S  G+       +  D+  + R E+S+     F K        +  E  +   L 
Sbjct: 2894 SSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLT 2953

Query: 877  KETLKREKTTSLVLTQEREMLE-KTYKEHLNSM--VVERQQLLQDLEDLRNVSETQQSLL 933
            +      +  S+    E  + E K Y   ++S+  ++ + QL ++ E + + S++ +S  
Sbjct: 2954 ESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE-VYDSSQSHES-F 3011

Query: 934  SDQILELKSSHKRELREREEVLCQAGASEQLA---SQRLERLEMEHDQERQEMMSKLLAM 990
            SD   EL  + ++   E   VL  A  +E  A   +  +  L     + +++ +    AM
Sbjct: 3012 SDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAM 3071

Query: 991  ENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSP-LSMLQSGCQVIGEEEVEGDGA 1049
            E + KA   +   E   +  +++  +  +K  Q++  P   +L+   Q    + +E    
Sbjct: 3072 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3131

Query: 1050 LSLLQ-QGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP-GLVMSSC 1107
            LS ++ +  +L E+     + +     +  +  +++ T +    + L++LE   L +   
Sbjct: 3132 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3191

Query: 1108 LDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVL-----SDLEDDEVRDLGSTGTSS 1162
             DE       +T        +Q ++++++    +         + + +E+ DL  +  S 
Sbjct: 3192 TDE--VHLLNDTLAS-----EQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQ 3244

Query: 1163 VQR----------QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMM--L 1210
             QR          Q+  + ES+  +E    L +++ +  +   L+ Q+    E++ +  +
Sbjct: 3245 KQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREM 3304

Query: 1211 CADCDRASEKKQDL------------LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE 1258
             +  DR  E    L            L    +LK+  K LE   + S   +LL E    +
Sbjct: 3305 SSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEE--KHSRIVELLNETEKYK 3362

Query: 1259 NDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIEN 1318
             D LQ   +M + R      + K L  E     +  KKM E+      L++  +E + + 
Sbjct: 3363 LDSLQTRQQMEKDRQ----VHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3418

Query: 1319 EELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVR 1378
             +L++   RLQG +++ Q+  ++R      E   E+  I        LN+     +   R
Sbjct: 3419 YKLDLEGQRLQGIMQEFQKQELER------EEKRESRRI----LYQNLNEPTTWSLTSDR 3468

Query: 1379 SVHHVIEECKQENQYLEGNTQLLEKVKA------HEIAWLHGTIQTHQERPRVQNQVILE 1432
            + + V+++ K E +  E N   L ++        HE+  +   +Q    + +V  Q   E
Sbjct: 3469 TRNWVLQQ-KIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3527

Query: 1433 ENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELK 1492
                     +     Q  I E+ L+   LQ+LT +  E  +++       S G   E L 
Sbjct: 3528 RLQFETADDEDFIWVQENIDEIILQ---LQKLTGQQGEEPSLV---SPSTSCGSLTERL- 3580

Query: 1493 AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE-----------DSISN 1541
                        ++Q  EL  + S+ L +E + LRN +  L E+           D+ S 
Sbjct: 3581 ------------LRQNAELTGHISQ-LTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSR 3627

Query: 1542 LKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE 1595
              L        +  S++E+W +      E   +QK ++  + ++ +LK      +L N  
Sbjct: 3628 FSLNGGANIEAIIASEKEVWNR------EKLTLQKSLKRAEAEVYKLK-----AELRNDS 3676

Query: 1596 LSQKNSQNQE 1605
            L Q  S + E
Sbjct: 3677 LLQTLSPDSE 3686


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,644,712
Number of Sequences: 37866
Number of extensions: 3672401
Number of successful extensions: 51115
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 499
Number of HSP's successfully gapped in prelim test: 1549
Number of HSP's that attempted gapping in prelim test: 16501
Number of HSP's gapped (non-prelim): 14862
length of query: 2133
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2015
effective length of database: 13,779,330
effective search space: 27765349950
effective search space used: 27765349950
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.