Search of human proteins with 148298722

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148298722 zinc finger protein 185 [Homo sapiens]
         (689 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148298722 zinc finger protein 185 [Homo sapiens]                  1382   0.0  
gi|238908501 sciellin isoform 3 [Homo sapiens]                         70   5e-12
gi|238908499 sciellin isoform 1 [Homo sapiens]                         70   5e-12
gi|238908497 sciellin isoform 2 [Homo sapiens]                         70   5e-12
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              55   2e-07
gi|33598968 LIM domain only 7 isoform 1 [Homo sapiens]                 51   4e-06
gi|30795231 brain abundant, membrane attached signal protein 1 [...    51   4e-06
gi|167736355 mucin 4 isoform a [Homo sapiens]                          50   5e-06
gi|157738619 smoothelin-like 1 [Homo sapiens]                          49   2e-05
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    49   2e-05
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         49   2e-05
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    48   3e-05
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        48   3e-05
gi|148806908 fibronectin type III domain containing 1 [Homo sapi...    47   6e-05
gi|7662228 synaptosomal-associated protein, 91kDa homolog [Homo ...    47   8e-05
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    47   8e-05
gi|82534351 microtubule-associated protein tau isoform 1 [Homo s...    46   1e-04
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    45   2e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    45   2e-04
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    45   2e-04
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    45   2e-04
gi|150170670 piccolo isoform 2 [Homo sapiens]                          45   2e-04
gi|150378539 piccolo isoform 1 [Homo sapiens]                          45   2e-04
gi|178557734 microtubule-associated protein tau isoform 6 [Homo ...    45   3e-04
gi|163310741 LIM and calponin homology domains 1 isoform a [Homo...    44   4e-04
gi|239742243 PREDICTED: HPX-153 homeobox [Homo sapiens]                44   5e-04
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]         44   5e-04
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    44   7e-04
gi|217035154 RCSD domain containing 1 [Homo sapiens]                   44   7e-04
gi|150378549 tangerin [Homo sapiens]                                   44   7e-04

>gi|148298722 zinc finger protein 185 [Homo sapiens]
          Length = 689

 Score = 1382 bits (3578), Expect = 0.0
 Identities = 689/689 (100%), Positives = 689/689 (100%)

Query: 1   MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRS 60
           MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRS
Sbjct: 1   MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRS 60

Query: 61  RATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVR 120
           RATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVR
Sbjct: 61  RATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVR 120

Query: 121 TANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEA 180
           TANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEA
Sbjct: 121 TANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEA 180

Query: 181 ASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARS 240
           ASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARS
Sbjct: 181 ASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARS 240

Query: 241 TPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPD 300
           TPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPD
Sbjct: 241 TPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPD 300

Query: 301 VEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPE 360
           VEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPE
Sbjct: 301 VEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPE 360

Query: 361 GLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEA 420
           GLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEA
Sbjct: 361 GLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEA 420

Query: 421 WQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVA 480
           WQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVA
Sbjct: 421 WQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVA 480

Query: 481 TKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPS 540
           TKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPS
Sbjct: 481 TKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPS 540

Query: 541 SCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNV 600
           SCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNV
Sbjct: 541 SCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNV 600

Query: 601 SSIEDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGICCHEYCFKCGI 660
           SSIEDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGICCHEYCFKCGI
Sbjct: 601 SSIEDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGICCHEYCFKCGI 660

Query: 661 CSKPMGDLLDQIFIHRDTIHCGKCYEKLF 689
           CSKPMGDLLDQIFIHRDTIHCGKCYEKLF
Sbjct: 661 CSKPMGDLLDQIFIHRDTIHCGKCYEKLF 689


>gi|238908501 sciellin isoform 3 [Homo sapiens]
          Length = 646

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 30/63 (47%), Positives = 41/63 (65%), Gaps = 2/63 (3%)

Query: 628 ICTYCNREIRDCPKITLEHLGICCHEYCFKCGICSKPMGDLL--DQIFIHRDTIHCGKCY 685
           +CTYC + +    K+ L+ L ICCH  CFKC IC +P+ +L   D I+I+R TIHC  CY
Sbjct: 578 MCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCY 637

Query: 686 EKL 688
            K+
Sbjct: 638 SKI 640


>gi|238908499 sciellin isoform 1 [Homo sapiens]
          Length = 688

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 30/63 (47%), Positives = 41/63 (65%), Gaps = 2/63 (3%)

Query: 628 ICTYCNREIRDCPKITLEHLGICCHEYCFKCGICSKPMGDLL--DQIFIHRDTIHCGKCY 685
           +CTYC + +    K+ L+ L ICCH  CFKC IC +P+ +L   D I+I+R TIHC  CY
Sbjct: 620 MCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCY 679

Query: 686 EKL 688
            K+
Sbjct: 680 SKI 682


>gi|238908497 sciellin isoform 2 [Homo sapiens]
          Length = 668

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 30/63 (47%), Positives = 41/63 (65%), Gaps = 2/63 (3%)

Query: 628 ICTYCNREIRDCPKITLEHLGICCHEYCFKCGICSKPMGDLL--DQIFIHRDTIHCGKCY 685
           +CTYC + +    K+ L+ L ICCH  CFKC IC +P+ +L   D I+I+R TIHC  CY
Sbjct: 600 MCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCY 659

Query: 686 EKL 688
            K+
Sbjct: 660 SKI 662


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 110/534 (20%), Positives = 182/534 (34%), Gaps = 77/534 (14%)

Query: 36   KGDKSWITKQDESEGRTIELPSGRSRATSFSSAGEVPK------PRPPSTRAPTGYIIRG 89
            +GD      + + E   +E P     A   S   E P+      P      AP       
Sbjct: 1857 EGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQ 1916

Query: 90   VFTKPIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMT---------TED 140
              T+ +++     +  P++ G     A        G  +P S   +           +ED
Sbjct: 1917 PETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESED 1976

Query: 141  YKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAAS----GVLRRTAPREHSYV 196
             + L    +      G+ + E E+   P +  E +   E A     GV     P+     
Sbjct: 1977 VEALE-VEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGV--EAQPKSEG-- 2031

Query: 197  LSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRTKASR 256
               A++  G TQ+T+        + VE     E++Q+     +   G    +     A  
Sbjct: 2032 -EEAQEVEGETQKTEGD-AQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQE 2089

Query: 257  AIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAP 316
            A       + P   G +   + GE          +    + AP+ EG  + P ++  EAP
Sbjct: 2090 AEG----EAQPESEGVEAPEAEGEA---------QKAEGIEAPETEG-EAQPESEGIEAP 2135

Query: 317  -CSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSS 375
                E Q +  G EA      DA   +   S+G     A       L  V+     G + 
Sbjct: 2136 EAEGEAQPESEGVEA-----QDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQ 2190

Query: 376  ATS--VSAVPADRKSN-------STAAQEDAKADPKGA-LADYEGKDVATRVGEAWQERP 425
              S  + A  A+ ++        +  A+E+A+ +P+G    + EG+      GE   E+ 
Sbjct: 2191 PESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK 2250

Query: 426  GAPRGGQGD----------PAVPAQQPADPSTP------ERQSSPSGSEQLVRRESCGSS 469
            G+P+   GD            VP  +P  P +P      +R  S +G     R  S G+ 
Sbjct: 2251 GSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSS-SRASSWGNC 2309

Query: 470  VLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGS 523
               D E   V            G P   +      T+   + ST EQ+ +P GS
Sbjct: 2310 WQKDSENDHVLGDTRSPDAKSTGTPHAER----KATRMYPESSTSEQEEAPLGS 2359



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 65/288 (22%), Positives = 97/288 (33%), Gaps = 36/288 (12%)

Query: 265 SMPSPAGSQELSSRGEEIVRLQILTPRA-GLRLVAPDVEGMRSSPGNKDKEAPCSRELQR 323
           S PS   S +   R        + +P + GL  VAP     R S   KD  +P    + +
Sbjct: 626 STPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHP-RHSHYRKDTHSPLDSSVTK 684

Query: 324 DLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGS-RPEGLAAVDIGSERGSSSATSVSAV 382
            +      R    D +      S  +  + A+G+ RP    ++      G+SSAT   AV
Sbjct: 685 QVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTPAV 744

Query: 383 PADRKS-----NSTAAQEDAKADPKGA--------LADYEGKDVATRVGEAWQERP---- 425
            +D  S     N+ +A     A  +           +D   K  A  +GE  ++ P    
Sbjct: 745 HSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQPSS 804

Query: 426 ------GAPRGGQGDP--AVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGK 477
                 G P  G   P  +    QP      E Q  PS     +    CG    T   G+
Sbjct: 805 PLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWL----CGRYCPTPPRGR 860

Query: 478 DV----ATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPS 521
                 ++  G          RG  G P   T+QP    +P   +  S
Sbjct: 861 PCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGAS 908


>gi|33598968 LIM domain only 7 isoform 1 [Homo sapiens]
          Length = 1349

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 44/197 (22%), Positives = 76/197 (38%), Gaps = 28/197 (14%)

Query: 491  PGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTA 550
            PG  R G+    + + +      P   N P+G   F    S     R P   +V+ +  A
Sbjct: 1168 PGIMRRGESLDNLDSPRSNSWRQPPWLNQPTG---FYASSSVQDFSRPPPQ-LVSTSNRA 1223

Query: 551  TSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNVSSIEDSFAME 610
                P   +P P++    +STT              V++ +  + R  + S+ +    + 
Sbjct: 1224 YMRNPSSSVPPPSAGSVKTSTTG-------------VATTQSPTPRSHSPSASQSGSQLR 1270

Query: 611  KKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGICCHEYCFKCGICSKPMGDLLD 670
             +   G           IC+YCN  +     + +E LG+C H +CFKC  C   +G    
Sbjct: 1271 NRSVSGKR---------ICSYCNNILGKGAAMIIESLGLCYHLHCFKCVACECDLGGSSS 1321

Query: 671  --QIFIHRDTIHCGKCY 685
              ++ I    ++C  CY
Sbjct: 1322 GAEVRIRNHQLYCNDCY 1338


>gi|30795231 brain abundant, membrane attached signal protein 1
           [Homo sapiens]
          Length = 227

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 52/221 (23%), Positives = 79/221 (35%), Gaps = 24/221 (10%)

Query: 358 RPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEG-KDVATR 416
           + EG A  + G+ +   S    +A PA+ K       +DA+    G   + EG KD A  
Sbjct: 25  KAEGAATEEEGTPK--ESEPQAAAEPAEAKEGKEKPDQDAE----GKAEEKEGEKDAAAA 78

Query: 417 VGEAWQERP----GAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLT 472
             EA +  P    GA       P  P Q+ A P       +P  +E              
Sbjct: 79  KEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAA---------- 128

Query: 473 DFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESC 532
               +  A   GE      G P+  +   A   Q+      P   + P  SE     +  
Sbjct: 129 --PAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKET 186

Query: 533 TSRVRSPSSCMVTVTVTATSEQPHIYIPAPASELDSSSTTK 573
            +   +PSS        A++E+P   + APA+  D + T K
Sbjct: 187 PAATEAPSSTPKAQGPAASAEEPK-PVEAPAANSDQTVTVK 226


>gi|167736355 mucin 4 isoform a [Homo sapiens]
          Length = 5284

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 122/610 (20%), Positives = 205/610 (33%), Gaps = 71/610 (11%)

Query: 36   KGDKSWITKQ--DESEGRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTK 93
            KG  +W   +    S G    L +G     S  +AG +P       R P+     G   +
Sbjct: 495  KGHTTWSQTELPSTSTGAATRLVTGNP---STGTAGTIP-------RVPSKVSAIGEPGE 544

Query: 94   PIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMT----TEDYKKLAPYNI 149
            P   SS      PK  G          T   G    SS  Y +T    T      +P   
Sbjct: 545  PTTYSSH-STTLPKTTGAGAQTQWTQETGTTGEALLSSPSYSVTQMIKTATSPSSSPMLD 603

Query: 150  RRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQE 209
            R +S    T        +  S+    + S A S      AP+      S   +S  P  +
Sbjct: 604  RHTSQQITTAPSTNHSTI-HSTSTSPQESPAVSQRGHTQAPQTTQE--SQTTRSVSPMTD 660

Query: 210  TQAPFIAKRVEVVEEDGPSE-KSQDPPALARSTPGSNSADG-GRTKASRAIWIECLPSMP 267
            T+               PSE   QD P ++ +T  + +  G G T  +    ++  PS  
Sbjct: 661  TKTVTTPGSSFTASGHSPSEIVPQDAPTISAATTFAPAPTGDGHTTQAPTTALQAAPSSH 720

Query: 268  S----PAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQR 323
                 P+G   LS  G   +   +++   G     P+ +   +S       A       +
Sbjct: 721  DATLGPSGGTSLSKTGALTLANSVVSTPGG-----PEGQWTSASASTSPDTAAAMTHTHQ 775

Query: 324  DLAGEEAFRAPNTDAARSSAQLSDGNVG----SGATGSRPEGLAAVDIGSER---GSSSA 376
              + E + +   ++ A S ++ +         SGA+G+ P G   +    E     S+ +
Sbjct: 776  AESTEASGQTQTSEPASSGSRTTSAGTATPSSSGASGTTPSGSEGISTSGETTRFSSNPS 835

Query: 377  TSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPA 436
                   +  +  S +A   A     G  +          + EA     G P  GQ  P 
Sbjct: 836  RDSHTTQSTTELLSASASHGAIPVSTGMASSIVPGTFHPTLSEA--STAGRPT-GQSSPT 892

Query: 437  VPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRG 496
             P+  P + +   R +    +     R S GS  ++      +A++  + +   P  P  
Sbjct: 893  SPSASPQETAAISRMAQTQRT-----RTSRGSDTIS------LASQATDTFSTVPPTP-- 939

Query: 497  GQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQPH 556
                P++ +     P T     SPSGS     +   T+ + + +   VT   +A++    
Sbjct: 940  ----PSITSTGLTSPQTETHTLSPSGS----GKTFTTALISNATPLPVTYASSASTGH-- 989

Query: 557  IYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNVSSIEDSFAMEKKPPCG 616
                 P    D+SS + G        + S VS+G       ++ SS           P  
Sbjct: 990  ---TTPLHVTDASSVSTGHATPLPVTSPSSVSTGHTTPLPVTDTSSESTGHV----TPLP 1042

Query: 617  STPYSERTTG 626
             T +S  +TG
Sbjct: 1043 VTSFSSASTG 1052


>gi|157738619 smoothelin-like 1 [Homo sapiens]
          Length = 512

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 93/417 (22%), Positives = 145/417 (34%), Gaps = 76/417 (18%)

Query: 144 LAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRT-APREHSYVLSAAKK 202
           + P  +  S  S +  E+ E++    S D       A +  +    AP E +   +    
Sbjct: 1   MLPGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAI 60

Query: 203 STGPTQETQAPFIAKRVEVVEEDGPSEKSQ-DPPALARSTPGSNSADGGRTKASRAIWIE 261
           + GP  E+      K+ +   EDG S + Q +   L      S    GG+  A   +  E
Sbjct: 61  NEGPPTES-----GKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE 115

Query: 262 CLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSREL 321
                 +  GSQE++ R EE                       +S P    KEA    E 
Sbjct: 116 DGEKEETTVGSQEMTGRKEET----------------------KSEP----KEA---EEK 146

Query: 322 QRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSA 381
           +  LA E+  +A   +A   S Q +D N        +PE  A V+    + +S   +   
Sbjct: 147 ESTLASEKQ-KAEEKEAKPESGQKADAN-----DRDKPEPKATVEEEDAKTASQEETGQR 200

Query: 382 VPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQ 441
                +    A  E+AKA+ + A+ + E K          + + GA             +
Sbjct: 201 KECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAE 260

Query: 442 PADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDR----------- 490
            A+P +P  +      EQ V +E  G        G  V     E W +            
Sbjct: 261 EAEPGSPSEE-----QEQDVEKEPEG--------GAGVIPSSPEEWPESPTGEGHNLSTD 307

Query: 491 ---PGAPRGGQGDPAVPTQQPAD-PSTPEQQNSPSGSEQF----VRRESCTSRVRSP 539
              P     GQ  P+     P+D P +P +  SPS  E+      RR S  +R R P
Sbjct: 308 GLGPDCVASGQTSPSASESSPSDVPQSPPE--SPSSGEKKEKAPERRVSAPARPRGP 362


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 92/468 (19%), Positives = 170/468 (36%), Gaps = 101/468 (21%)

Query: 73  KPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSS 132
           KP+  + +AP     +   +   DS S  + + PK N  PK     V+     PP+P+ +
Sbjct: 151 KPQAKAAKAPP----KKAKSSDSDSDSSSEDEPPK-NQKPKITPVTVKAQTKAPPKPARA 205

Query: 133 GYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAPRE 192
             K+     K  +  +   SS+S D  EEE+    P                 ++T P++
Sbjct: 206 APKIANG--KAASSSSSSSSSSSSDDSEEEKAAATP-----------------KKTVPKK 246

Query: 193 HSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRT 252
                +  K +T PT+++ +           ED  S++ ++     ++ PG  S      
Sbjct: 247 QVVAKAPVKAATTPTRKSSS----------SEDSSSDEEEEQKKPMKNKPGPYS------ 290

Query: 253 KASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKD 312
                       S+P P+      S G +        P+  +    P    + SS  + D
Sbjct: 291 ------------SVPPPSAPPPKKSLGTQ-------PPKKAVEKQQP----VESSEDSSD 327

Query: 313 KEAPCSRELQRDLAGEEAFRA-----PNTDAARSSAQLSDGNVG-SGATGSRPEGLAAVD 366
           +    S E ++        +A     P   AA SS+  SD +        S+P G     
Sbjct: 328 ESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNS 387

Query: 367 IGSERGSSSATSVSAVPA------------DRKSNSTAAQEDAKADPKGALADYEGKDVA 414
                 ++ + +V    A             RK++S++++E++ +  +    +   K VA
Sbjct: 388 SNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEE----EKTKKMVA 443

Query: 415 TRVGEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDF 474
           T   +A        +     PA  A Q +  S+ +  SS S  E+    E    S +   
Sbjct: 444 TTKPKA------TAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEE----EKTSKSAVK-- 491

Query: 475 EGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSG 522
             K      G A   +P + + G+ + +      +D S+ E++    G
Sbjct: 492 --KKPQKVAGGAAPSKPASAKKGKAESS--NSSSSDDSSEEEEEKLKG 535



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 84/357 (23%), Positives = 134/357 (37%), Gaps = 64/357 (17%)

Query: 311 KDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVD---I 367
           K K  P + + Q     + A  AP     ++++  S  +  S +  S  E  AA     +
Sbjct: 184 KPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTV 243

Query: 368 GSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGA 427
             ++  + A   +A    RKS+S+   ED+ +D +    + + K +  + G      P +
Sbjct: 244 PKKQVVAKAPVKAATTPTRKSSSS---EDSSSDEE----EEQKKPMKNKPGPYSSVPPPS 296

Query: 428 ---PRGGQGDP----AVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDV- 479
              P+   G      AV  QQP + S      S S SE+   ++    +V++    K   
Sbjct: 297 APPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEE--EKKPPTKAVVSKATTKPPP 354

Query: 480 ATKVGEAWQDR-----------PGAPRG----GQGDPAVPTQQPA-DPSTPEQQNSPSGS 523
           A K  E+  D            P  P G        PAV T+ PA  P+   +Q    G 
Sbjct: 355 AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQ 414

Query: 524 EQFVRRESCTSRVRSPSSC-------MVTVTVTATSEQPHIYIP---APASELDSSS--- 570
           +   R+   +S     SS        MV  T    + +  + +P   AP    DSSS   
Sbjct: 415 KLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474

Query: 571 ----------TTKGILFVKEYVNASEVSSGKPVSAR-----YSNVSSIEDSFAMEKK 612
                     T+K  +  K    A   +  KP SA+      SN SS +DS   E++
Sbjct: 475 SSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE 531



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 92/452 (20%), Positives = 157/452 (34%), Gaps = 83/452 (18%)

Query: 39  KSWITKQDESEGRTIELPSGRSRATSFSSAGEVPKPRPPSTRAP--TGYIIRGVFTKPID 96
           K  + K  + + +  + P  +++++  S +    +  PP  + P  T   ++     P  
Sbjct: 143 KQPVQKGVKPQAKAAKAPPKKAKSSD-SDSDSSSEDEPPKNQKPKITPVTVKAQTKAP-- 199

Query: 97  SSSQPQQQFPK-ANGTPKSAASLVRTAN----------AGPPRPSSSGYKMTTEDYKKLA 145
              +P +  PK ANG   S++S   +++          A  P+ +    ++  +   K A
Sbjct: 200 --PKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAA 257

Query: 146 PYNIRRSSTSGDTEEEEEEE--------------VVPFSSDEQKRR--SEAASGVLRRTA 189
               R+SS+S D+  +EEEE              V P S+   K+   ++     + +  
Sbjct: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQ 317

Query: 190 PREHSYVLSAAKKSTGPTQE------------TQAPFIAKRVEVVEEDGPSEKSQDP--P 235
           P E S   S    S+   ++            T+ P   K  E   +   S+ S+D   P
Sbjct: 318 PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAP 377

Query: 236 ALARSTPGSNSADGGRTKASRAIWIECLPSMP-------------SPAGSQELSSRGEEI 282
           +    T  ++S     T  S A+     P  P             S +  +E SS  EE 
Sbjct: 378 SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEK 437

Query: 283 VRLQILTPR------AGLRLVAPDV-EGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPN 335
            +  + T +      A L L A    +G R S  + D  +            EE     +
Sbjct: 438 TKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSS-----------SEEEEEKTS 486

Query: 336 TDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQE 395
             A +   Q     V  GA  S+P         S   SSS  S        K   +   +
Sbjct: 487 KSAVKKKPQ----KVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQ 542

Query: 396 DAKADPKGALADYEGKDVATRVGEAWQERPGA 427
             KA+   AL    GK       E  +++  A
Sbjct: 543 APKANGTSALTAQNGKAAKNSEEEEEEKKKAA 574


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 83/412 (20%), Positives = 152/412 (36%), Gaps = 69/412 (16%)

Query: 59   RSRATSFSSAGEVPKPRPPS-TRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAAS 117
            R++A     A   P P PP+ T  P       +       +  P    P     PK A +
Sbjct: 2383 RAKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARA 2442

Query: 118  LVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRR 177
               +   GP RP      +   D++ +     +++  +    E+      P +   Q+ +
Sbjct: 2443 AEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLRED------PGAGGWQEPK 2496

Query: 178  SEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFI-AKRVEVVEEDGPS---EKSQD 233
            S  + G          SY  +A       + E +AP+  A   ++ +E GP    E S +
Sbjct: 2497 SLLSLG----------SYPPAAG------SSEPKAPWPKATDGDLAQEPGPGLTFEDSGN 2540

Query: 234  PPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAG 293
            P +  ++    + A+   + +S +       S  S +GS+   + GEE            
Sbjct: 2541 PKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSE---TEGEE------------ 2585

Query: 294  LRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAP--NTDAARSSAQLSDGNVG 351
                           G+K+ +  C    +   A      +P  ++ ++ SS+  S  +  
Sbjct: 2586 --------------EGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSS 2631

Query: 352  SGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDA--KADPKGALADYE 409
            S ++ S     ++    S   SSS++S S+  +   S+S+   ED+   +D + A A   
Sbjct: 2632 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTA 2691

Query: 410  GKDVATRV-----GEAWQERPGAPRGGQGDPA----VPAQQPADPSTPERQS 452
            G      +      +A + RP A   G+  PA     P  QP  P  P+ Q+
Sbjct: 2692 GPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQPKAQA 2743



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 88/381 (23%), Positives = 140/381 (36%), Gaps = 47/381 (12%)

Query: 202  KSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALAR--STPGSNSAD----GGRTKAS 255
            K+ G  ++  A     R   +EE  P+++    P      STPGS  +       R KA 
Sbjct: 2328 KARGRGRKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAP 2387

Query: 256  RAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEA 315
            +A      P  PSPA     S    E    ++  P   L   AP +    + P  K K+A
Sbjct: 2388 KA---RPAPPQPSPAPPAFTSCPAPEPFA-ELPAPATSLA-PAPLITMPATRP--KPKKA 2440

Query: 316  PCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVD---IGSERG 372
              + E     +G +  R P  +A     +L    V S  +    E L   +    G  + 
Sbjct: 2441 RAAEE-----SGAKGPRRPGEEA-ELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQE 2494

Query: 373  SSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQ 432
              S  S+ + P    S+          +PK         D+A   G      PG      
Sbjct: 2495 PKSLLSLGSYPPAAGSS----------EPKAPWPKATDGDLAQEPG------PGLTFEDS 2538

Query: 433  GDPAVPAQQPADPS-TPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRP 491
            G+P  P +  A+     E +SS S S       S  SS  ++ EG++   K G+      
Sbjct: 2539 GNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDG----- 2593

Query: 492  GAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTAT 551
            G   GG+   A  ++  +  S+    +S S S       S +S   S SS   + + +++
Sbjct: 2594 GCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2653

Query: 552  SEQPHIYIPAPASELDSSSTT 572
            S        + +S   SSS++
Sbjct: 2654 SSSSS---SSSSSSSSSSSSS 2671



 Score = 36.6 bits (83), Expect = 0.080
 Identities = 39/146 (26%), Positives = 52/146 (35%), Gaps = 28/146 (19%)

Query: 425 PGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVG 484
           P  P   +G PA PA  PA   T  R+    G E  V   +   SV              
Sbjct: 336 PPPPAPPKGPPAPPAATPAGVYTVFREQ---GREHRVVAPTFVPSV-------------- 378

Query: 485 EAWQDRPGA---------PRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSR 535
           EA+ +RPG           R  + +   P    A P +P   + P G  +  +     S 
Sbjct: 379 EAFDERPGPIQIASQARDARAREREAGRPGVLQAPPGSPRPLDRPEGLRE--KNSVIRSL 436

Query: 536 VRSPSSCMVTVTVTATSEQPHIYIPA 561
            R P +   TV  T  S  P  Y+PA
Sbjct: 437 KRPPPADAPTVRATRASPDPRAYVPA 462


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
            sapiens]
          Length = 1450

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 110/510 (21%), Positives = 177/510 (34%), Gaps = 61/510 (11%)

Query: 44   KQDESEGRTIELPSGRSRATSFSSAGEVPKPR----PPSTRAPTGYIIRGVFTKPIDSSS 99
            KQ++SE    E  S  + A+       V K +    P + RAP+         K + +++
Sbjct: 758  KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAA 817

Query: 100  QPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTE 159
            Q +Q+ P     P            GP    S G  + T    +  P     SS      
Sbjct: 818  QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDS 877

Query: 160  EEEEE---EVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIA 216
            EEE E   +V P     Q R + A +    + +PR+ +      K      Q  +     
Sbjct: 878  EEEAETLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933

Query: 217  KRVEVVEEDGPSEKSQDP-----PALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAG 271
               E  + DG +  +        P L    P  + A    T A          +  S + 
Sbjct: 934  SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASEST 993

Query: 272  SQELSSRGEE---IVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGE 328
            ++  SS  E+   I   Q LTP     +V       R +P      A  S+E  R   G+
Sbjct: 994  ARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK 1053

Query: 329  -EAFRAPNTDAA----RSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVP 383
             +   A   D+A     +++  S      G    R   L  V   ++   SS  S     
Sbjct: 1054 KQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDS----- 1108

Query: 384  ADRKSNSTAAQEDAKADPKGALADYEGKDVATRV--------GEAWQERPGAPR----GG 431
             D   +S+ ++ED +  P+GA + +      +R          E+ ++   AP      G
Sbjct: 1109 EDSSDSSSGSEEDGEG-PQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSG 1167

Query: 432  QGDPAV-PAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDR 490
               P + PA   A  +TP+  SSPS S  L  ++        D +GK          Q+ 
Sbjct: 1168 YMTPGLTPANSQASKATPKLDSSPSVSSTLAAKD--------DPDGK----------QEA 1209

Query: 491  PGAPRGGQGDPAVPTQQPADPSTPEQQNSP 520
                  G   P    ++ A  +TP++   P
Sbjct: 1210 KPQQAAGMLSPKTGGKEAASGTTPQKSRKP 1239



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 92/438 (21%), Positives = 148/438 (33%), Gaps = 72/438 (16%)

Query: 108 ANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVV 167
           A GTP   A+      AG     +   K   +            S +S +   + EEE  
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEED------------SESSSEESSDSEEETP 354

Query: 168 PFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGP 227
              +  Q + S   S V   +AP + S    AA    G T    A   A + E   +   
Sbjct: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSS 414

Query: 228 SEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQI 287
            E   +  A A++ P       G+    RA          + A ++E   +G      + 
Sbjct: 415 EESDSEEEAPAQAKP------SGKAPQVRA----------ASAPAKESPRKGAAPAPPRK 458

Query: 288 LTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSD 347
             P A    V    E  RSS          S E   D     A  A        S Q+  
Sbjct: 459 TGPAAAQVQVGKQEEDSRSS----------SEESDSDREALAAMNAAQVKPLGKSPQVKP 508

Query: 348 GN-VGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALA 406
            + +G G  G   +G   V  G    ++ +  V     D +S+S  + + +  +   A+A
Sbjct: 509 ASTMGMGPLG---KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 565

Query: 407 DYEGKDVATRVGEAWQERP-GAPRGGQGDPAVP------AQQPADPSTPERQSSPSGSEQ 459
             + K     +G   Q +P  +P  G    A P      A++P D S    +SS S   +
Sbjct: 566 PAQEKS----LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 621

Query: 460 ----------------LVRRESCGSSVLTDFEGKDVATKVGEAWQDRPG---APRGGQGD 500
                           + + ++C     T    K    +VG     + G   +P G    
Sbjct: 622 EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA 681

Query: 501 PAVPTQQPADPSTPEQQN 518
            A  TQ+PA+ S+  +++
Sbjct: 682 VAGGTQRPAEDSSSSEES 699



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 117/602 (19%), Positives = 206/602 (34%), Gaps = 125/602 (20%)

Query: 50   GRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFT----------------- 92
            G+  E     S  +S SS GEVP    P+     G I++   T                 
Sbjct: 539  GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 598

Query: 93   ----KPIDSSSQPQQQFPKANGTPKSAASLVRTANAGP----PRPSSSGYKMTTEDYKKL 144
                KP+D+S   ++    A+     AA  +  A A P    P+  +   K  T    K+
Sbjct: 599  VKAEKPMDNSESSEESSDSADSEEAPAA--MTAAQAKPALKIPQTKACPKKTNTTASAKV 656

Query: 145  APYNI-----RRSSTS-----------GDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRT 188
            AP  +     R++ T+           G T+   E+      SD ++ ++  A  V +  
Sbjct: 657  APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK 716

Query: 189  APREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSAD 248
            +  +   V +A+    G   +  AP +  +         +EK +D  +   S   S+S +
Sbjct: 717  SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSES---SEEESDSEE 773

Query: 249  GGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSP 308
               + A     ++   +  +PA ++  S++G         T  A  ++V    +  + SP
Sbjct: 774  AAASPAQVKTSVKKTQAKANPAAARAPSAKG---------TISAPGKVVTAAAQAKQRSP 824

Query: 309  GNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIG 368
                K  P  R  Q                  +S  L+ G          P  + +V   
Sbjct: 825  S---KVKPPVRNPQ------------------NSTVLARG----------PASVPSV--- 850

Query: 369  SERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAP 428
               G + AT+  A     + + ++ +E    +    LA  +      ++  A      +P
Sbjct: 851  ---GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP 907

Query: 429  RGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQ 488
            R G          P+     ++  S S SE+            +D +G+  A  V  A  
Sbjct: 908  RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEE------------SDSDGEAPAA-VTSAQV 954

Query: 489  DRPGA----PRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMV 544
             +P      P      PA    Q    STP +  +   + +    ES    V   + C+ 
Sbjct: 955  IKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLT 1014

Query: 545  ----TVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNV 600
                T  VT  +  P I   AP + +  +S++K          +S +S GK      + V
Sbjct: 1015 PGIRTNVVTMPTAHPRI---APKASMAGASSSK---------ESSRISDGKKQEGPATQV 1062

Query: 601  SS 602
             S
Sbjct: 1063 DS 1064



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 106/566 (18%), Positives = 192/566 (33%), Gaps = 71/566 (12%)

Query: 67   SAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVRT-ANAG 125
            S G+   P  P    PT   ++    +  +SS +       A    +   S+ +T A A 
Sbjct: 734  SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793

Query: 126  PPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVL 185
            P    +   K T     K+        + +   ++    +V P   + Q       S VL
Sbjct: 794  PAAARAPSAKGTISAPGKVV-------TAAAQAKQRSPSKVKPPVRNPQN------STVL 840

Query: 186  RR---TAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTP 242
             R   + P     V +AA+  TGP +++ +          EE+  SE+  +   LA+  P
Sbjct: 841  ARGPASVPSVGKAVATAAQAQTGPEEDSGSS---------EEESDSEEEAE--TLAQVKP 889

Query: 243  GSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVE 302
                   G+T   RA      P+  SP      +  G+        T  +  +    D  
Sbjct: 890  S------GKTHQIRAA---LAPAKESPRKGAAPTPPGK--------TGPSAAQAGKQDDS 932

Query: 303  GMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGL 362
            G  S   + D EAP +    + +     F  PN   A  +A  +     S    +R    
Sbjct: 933  GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992

Query: 363  AAVDIGSERGSSSATSVSA--VPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEA 420
             A    SE         +    P  R +  T      +  PK ++A       ++R+ + 
Sbjct: 993  TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052

Query: 421  WQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVA 480
             ++   A +       +PA  P   S   + ++     +L   +    +  +  + +D +
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1112

Query: 481  TKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRR---ESCTSRVR 537
                 + +D      G QG  +  T  P          +PS +E  V     ES    V 
Sbjct: 1113 DSSSGSEED----GEGPQGAKSAHTLGP----------TPSRTETLVEETAAESSEDDVV 1158

Query: 538  SPSSCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARY 597
            +PS  +++  +T      +        +LDSS +    L  K+  +  + +  +  +   
Sbjct: 1159 APSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML 1218

Query: 598  SNVSSIEDSFAMEKKPPCGSTPYSER 623
            S  +         K+   G+TP   R
Sbjct: 1219 SPKTG-------GKEAASGTTPQKSR 1237


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 93/414 (22%), Positives = 148/414 (35%), Gaps = 67/414 (16%)

Query: 109  NGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEE--EEEV 166
            +GTP +AA+   ++    P+  +S   +        AP NI  S T+            +
Sbjct: 2314 SGTPPTAANYPSSSRT--PQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARM 2371

Query: 167  VPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDG 226
             P  S               R + R    +L  A+  T P+  +Q+   ++R        
Sbjct: 2372 APALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAP-----S 2426

Query: 227  PSEKSQDPPALARSTPGSNSADGGRTKASRAIWIE--CLPSMPSP-AGSQELSSRGEEIV 283
            PS +    P+ +   P     D  R+    A   +  CL +  +P AGSQ LSS      
Sbjct: 2427 PSSRMGQAPSQSLLPPAQ---DQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGA---- 2479

Query: 284  RLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSA 343
             +   T  AG      D  GM S P                     A   P++D     A
Sbjct: 2480 -VATTTSSAG------DHNGMLSVP---------------------APGVPHSDVGEPPA 2511

Query: 344  QLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQE---DAKAD 400
                    +GA   +P  LAA+    ER SSS++S S+  +   S+S+++      + +D
Sbjct: 2512 S-------TGA--QQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSD 2562

Query: 401  PKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQL 460
             +G+    + +    RV         A R G+     PA++    S+    SS S S   
Sbjct: 2563 SEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSS- 2621

Query: 461  VRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTP 514
                S  SS  +       ++    +    P  P    G  A+P  +PA P  P
Sbjct: 2622 -SSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP----GPQALP--KPASPKKP 2668



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 53/224 (23%), Positives = 83/224 (37%), Gaps = 41/224 (18%)

Query: 378 SVSAVPADRKSN-STAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPA 436
           S +  P  R+++ ST+A   + +D   + +        T         P + R G+GD  
Sbjct: 250 STTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGD-- 307

Query: 437 VPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRG 496
            P  +P   ST +R SSP         E+      + +E KD   K   A +  P   R 
Sbjct: 308 APFSEPGTTST-QRPSSP---------ETATKQPSSPYEDKDKDKKEKSATRPSPSPERS 357

Query: 497 GQG-DPAVPT------------------------QQPADPSTPEQQNSPSGSEQFVRRES 531
             G +P  PT                          P++ S    ++ P   E+  +  S
Sbjct: 358 STGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSS 417

Query: 532 CTSRVRSPSSCMVTVTVTATSEQPHIYIPAPAS--ELDSSSTTK 573
             S   SP    V+   +++ E P    PAP S  E+ SS T+K
Sbjct: 418 SESSPPSPQPTKVSRHASSSPESPK-PAPAPGSHREISSSPTSK 460



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 105/503 (20%), Positives = 174/503 (34%), Gaps = 68/503 (13%)

Query: 42  ITKQDESEGRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSS-Q 100
           + ++D + G   E P  R   T      E+ + +    RA       G+    +D SS  
Sbjct: 98  LLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAF-----GISDSYVDGSSFD 152

Query: 101 PQQQFPKAN---GTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGD 157
           PQ++  +A      P    SLV        R SSS    T +  KK    +  R S S  
Sbjct: 153 PQRRAREAKQPAPEPPKPYSLV--------RESSSSRSPTPKQKKKKKKKDRGRRSESSS 204

Query: 158 TEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAK 217
              E ++     SS ++K RSE+ S   +  +P   S   S  KK       T AP    
Sbjct: 205 PRRERKK-----SSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAP---- 255

Query: 218 RVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSS 277
                     S ++    +   ++    S    R+ A++          PSPA  +    
Sbjct: 256 ---------KSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGR---- 302

Query: 278 RGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTD 337
           RGE           +  R  +P+    + S   +DK+        +D   + A R P+  
Sbjct: 303 RGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKD--------KDKKEKSATR-PSPS 353

Query: 338 AARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDA 397
             RSS         +G     P  L A   G      + T +S  P +  S ++  ++  
Sbjct: 354 PERSS---------TGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRD-- 402

Query: 398 KADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGS 457
           ++ PK    +   +  ++       +     R     P  P   PA  S  E  SSP+  
Sbjct: 403 RSPPKS--PEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTS- 459

Query: 458 EQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQ 517
               +  S G +          + ++G +    P   + G+     PT++    S   Q 
Sbjct: 460 ----KNRSHGRAKRDKSHSHTPSRRMGRS--RSPATAKRGRSRSRTPTKRGHSRSRSPQW 513

Query: 518 NSPSGSEQFVRRESCTSRVRSPS 540
                ++++ R  S   R RS S
Sbjct: 514 RRSRSAQRWGRSRSPQRRGRSRS 536



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 64/250 (25%), Positives = 93/250 (37%), Gaps = 42/250 (16%)

Query: 30   KVRTTLKG-DKSWITKQDESEGRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIR 88
            K RT L+   +S  + + +S+ R   L   RSR+ S     + P+  P   RA +G    
Sbjct: 1568 KTRTPLRQRSRSGSSPEVDSKSR---LSPRRSRSGSSPEVKDKPRAAP---RAQSG---- 1617

Query: 89   GVFTKPIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYN 148
                    S S P+ + P     P+ + S   +   GP    SS  + + E   K     
Sbjct: 1618 --------SDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSR--T 1667

Query: 149  IRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQ 208
             RR S S    + +       S    +RRS  +S  L R A       LS   +S   + 
Sbjct: 1668 ARRGSRSSPEPKTK-------SRTPPRRRSSRSSPELTRKAR------LSRRSRSASSSP 1714

Query: 209  ETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPS 268
            ET++     R        PS  S +P   +RS+    SA   RTK +           P 
Sbjct: 1715 ETRS-----RTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSR---RGRSPSPK 1766

Query: 269  PAGSQELSSR 278
            P G Q   SR
Sbjct: 1767 PRGLQRSRSR 1776



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 79/368 (21%), Positives = 125/368 (33%), Gaps = 47/368 (12%)

Query: 240  STPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEI-VRLQILTPRAGLRLVA 298
            + P  N A G RT A+ A         P  A +   SSR  +      ++ PR+      
Sbjct: 2291 TAPAVNLA-GARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAP 2349

Query: 299  PDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAF--RAPNTDAARSSAQLSDGNVGSGATG 356
             ++ G R++          +R +   L+G      R P +   R S + S   +    + 
Sbjct: 2350 VNIAGSRTAAALAPASLTSAR-MAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSR 2408

Query: 357  SRPEGLAAVDIGSERGSSSATSVSAVPADR---------KSNSTAAQED------AKADP 401
            + P   +   + SER  S ++ +   P+           +S   +A  D      A+  P
Sbjct: 2409 TPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTP 2468

Query: 402  KGALADYEGKDVATRVGEAWQER-------PGAPRGGQGDP--AVPAQQPA-----DPST 447
                       VAT    A           PG P    G+P  +  AQQP+      P+ 
Sbjct: 2469 VAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAK 2528

Query: 448  PERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPG-----------APRG 496
              R SS S S       S  SS  +   G   +   G +   +P            AP+ 
Sbjct: 2529 ERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKE 2588

Query: 497  G--QGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQ 554
               +G P  PT       +    +S S S       S +S   S SS   + + +++S  
Sbjct: 2589 AVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2648

Query: 555  PHIYIPAP 562
            P    P P
Sbjct: 2649 PSPAKPGP 2656



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 83/372 (22%), Positives = 121/372 (32%), Gaps = 66/372 (17%)

Query: 111  TPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFS 170
            TP SA S  R  +   P PSS   +M     + L P             +++    VP +
Sbjct: 2409 TPPSAPSQSRMTSERAPSPSS---RMGQAPSQSLLP-----------PAQDQPRSPVPSA 2454

Query: 171  SDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQE------TQAPFIAKRVEVVEE 224
              +Q R       ++ +T P   S  LS+   +T  +           P        V E
Sbjct: 2455 FSDQSRC------LIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGE 2508

Query: 225  DGPSEKSQDPPALARSTPGSN--SADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEI 282
               S  +Q P ALA   P     S+    + +S +       S  S +GS    S G  +
Sbjct: 2509 PPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSL 2568

Query: 283  VRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSS 342
                 + P   L+ V         SP       P  +E  R+    E   A     + SS
Sbjct: 2569 P----VQPEVALKRVP--------SP------TPAPKEAVREGRPPEPTPAKRKRRSSSS 2610

Query: 343  AQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPK 402
            +  S  +  S ++ S     ++    S   SSS++S S  PA     +       K  P 
Sbjct: 2611 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPP 2670

Query: 403  GALADYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSP-----SGS 457
                           GE     P  P     D    +  P +   P  Q SP     S S
Sbjct: 2671 ---------------GERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSS 2715

Query: 458  EQLVRRESCGSS 469
            E+  RR   G S
Sbjct: 2716 ERGSRRGQRGDS 2727



 Score = 37.4 bits (85), Expect = 0.047
 Identities = 104/516 (20%), Positives = 175/516 (33%), Gaps = 62/516 (12%)

Query: 48   SEGRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPK 107
            S  R+    SGRSR+ + +  G   + R P+ R       R     P   S + + + P 
Sbjct: 635  SRSRSPARRSGRSRSRTPARRGR-SRSRTPARRG------RSRSRTPARRSGRSRSRTPA 687

Query: 108  ANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVV 167
              G  +S     RT   G  R  S                 +RR  +   T +       
Sbjct: 688  RRGRSRS-----RTPRRGRSRSRSL----------------VRRGRSHSRTPQRRGRSG- 725

Query: 168  PFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKS---TGPTQETQAPFIAKRVEVVEE 224
              SS E+K +S  +    R  +  E      ++++S   + P  + ++    +R      
Sbjct: 726  --SSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSS 783

Query: 225  DGPSEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVR 284
              P +KSQ PP  +RS      A                P   S   S++  S      +
Sbjct: 784  PCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPK 843

Query: 285  LQILTPRAGLRLVAPDVEGMRSSP-------GNKDKEAPCSRELQRDLAGEEAFRAPNTD 337
            ++  TP     + +P       +P        + D E       +   +G    R  ++ 
Sbjct: 844  VKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSST 903

Query: 338  AARSSAQLSDGNVGSGATGSRPEGLAAVD------IGSERGSSSATSVSAVPADRKSNST 391
              R S         S ++  +P+  A +        GS   S S  +    P   +S S 
Sbjct: 904  PPRQSP--------SRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSP 955

Query: 392  AAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPADPS-TPER 450
             +  +++  P+ + +     D  T+V      R          P V AQ P  PS +  +
Sbjct: 956  CSNVESRLLPRYSHSGSSSPD--TKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSK 1013

Query: 451  QSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPAD 510
               P    +    +SC  S L+   G   +T  GE++         GQ   +      +D
Sbjct: 1014 SPCPQEKSKDSLVQSCPGS-LSLCAGVKSSTPPGESYFGVSSLQLKGQSQTS--PDHRSD 1070

Query: 511  PSTPEQQNSPSGSEQFVRRESCTSR-VRSPSSCMVT 545
             S+PE + S S S     +   + +  RS SS  VT
Sbjct: 1071 TSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVT 1106



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 118/576 (20%), Positives = 189/576 (32%), Gaps = 46/576 (7%)

Query: 9   RTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRSRATSFSSA 68
           + K +   P  + ++   K+ + R+T    KS    +  S        + RSR+ S ++ 
Sbjct: 226 KRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAK 285

Query: 69  GEVP-----KPRPPSTRAPTG---YIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVR 120
                     P P S R   G   +   G  +    SS +   + P +    K      +
Sbjct: 286 THTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEK 345

Query: 121 TANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEA 180
           +A    P P  S    T  +     P    R   S      +     P S +     SEA
Sbjct: 346 SATRPSPSPERSS---TGPEPPAPTPLLAERHGGS-----PQPLATTPLSQEPVNPPSEA 397

Query: 181 ASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALAR- 239
            S    R+ P+    +  ++   + P     +P   K          S K    P   R 
Sbjct: 398 -SPTRDRSPPKSPEKLPQSSSSESSPP----SPQPTKVSRHASSSPESPKPAPAPGSHRE 452

Query: 240 --STPGSNSADGGRTKASRAIWIECLPSMP-SPAGSQELSSRGEEIVRLQILTPRAGLRL 296
             S+P S +   GR K  ++      PS     + S   + RG    R +  T R   R 
Sbjct: 453 ISSSPTSKNRSHGRAKRDKSH--SHTPSRRMGRSRSPATAKRGRS--RSRTPTKRGHSRS 508

Query: 297 VAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDA-ARS-SAQLSDGNVGSGA 354
            +P     RS+       +P  R   R        R+ NT    RS SA+    +  S A
Sbjct: 509 RSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPA 568

Query: 355 TGSRPEGLAAVDIGSERGSSSAT--SVSAVPADRKSNSTAAQEDAKADPKGALADYEGKD 412
           T  R         G  R  + A   S S  P  R+S S       ++  +          
Sbjct: 569 TRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRS--RSRTPARRRSR 626

Query: 413 VATRVGEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLT 472
             + V    + R  A R G+     PA++    S    +   S S    RR         
Sbjct: 627 TRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRS-------- 678

Query: 473 DFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESC 532
              G+  +       + R   PR G+       ++    S   Q+   SGS    + +S 
Sbjct: 679 ---GRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSR 735

Query: 533 TSRVRSPSSCMVTVTVTATSEQPHIYIPAPASELDS 568
           TS+ RS S+    +  +  S +    + +P S+  S
Sbjct: 736 TSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKS 771


>gi|148806908 fibronectin type III domain containing 1 [Homo sapiens]
          Length = 1894

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 112/479 (23%), Positives = 171/479 (35%), Gaps = 92/479 (19%)

Query: 93   KPIDSSSQPQQQFPKANGT---PKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNI 149
            KP  ++ +   +F    G    P S+      + A P  PS S      + + KL+    
Sbjct: 823  KPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHS------DSHPKLS---- 872

Query: 150  RRSSTSGDTEEEEE------EEVVPFSSD-------EQKRRSEAASGVLRRTAPREHSYV 196
              S   GD E+E+        + VP SS        E  RRS      L R  P      
Sbjct: 873  --SGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEP------ 924

Query: 197  LSAAKKSTGPTQETQAPF--IAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRTKA 254
            +    KSTG     Q  +  +A + + V++   ++     P   ++ PGS          
Sbjct: 925  IPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSP---KAQPGSTDRHAS---- 977

Query: 255  SRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKE 314
                     P+ P  A SQ+  S     V  ++   RA  +   P V   +  PG + ++
Sbjct: 978  ---------PARPPAARSQQHPS-----VPRRMTPGRAPQQQPPPPVATSQHHPGPQSRD 1023

Query: 315  APCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERG-S 373
            A  S    R L+  +A R   T   RS +  SD    S + G  P  L   D  ++    
Sbjct: 1024 AGRSPSQPR-LSLTQAGRPRPTSQGRSHSS-SDPYTAS-SRGMLPTALQNQDEDAQGSYD 1080

Query: 374  SSATSVSAVPADRKSNSTAAQEDAKADPKGALADYE-----GKDVATRVGEAWQE-RPGA 427
              +T V A      +++  A+E A + PK    +       G D  ++ G A    RP  
Sbjct: 1081 DDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSR 1140

Query: 428  PRGGQGDPAVPAQQ-PADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEG--KDVATKVG 484
            P G Q    VP++  P     P ++   S S+Q V  E         F+G  +D+ +   
Sbjct: 1141 PGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSV 1200

Query: 485  EAW---------QDRPG-------------APRGGQGDPAVPTQQPADPSTPEQQNSPS 521
              W         +D  G             APRGG   P      P   S+P   + PS
Sbjct: 1201 PKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPS 1259



 Score = 33.9 bits (76), Expect = 0.52
 Identities = 83/393 (21%), Positives = 140/393 (35%), Gaps = 81/393 (20%)

Query: 70  EVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTP--KSAASLVR------T 121
           E P+P  PS RAP                     Q P    +P  ++A  L+        
Sbjct: 473 EKPEPSSPSPRAPA------------------SSQHPSVPASPQGRNAKDLLLDLKNKIL 514

Query: 122 ANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTE--EEEEEEVVPFSSDEQKRRSE 179
           AN G PR      K   E        +++ +  +G+ E    E+  + P  + +QKR   
Sbjct: 515 ANGGAPRKPQLRAKKAEE-------LDLQSTEITGEEELGSREDSPMSPSDTQDQKR--- 564

Query: 180 AASGVLRRTAPREHSYVLSAAKKSTGPTQ-ETQAPFIAKRVEVVEEDGPSEKSQDPPALA 238
                LR  +   HS V      + G T    + P + +R E V++ G S  +Q  P   
Sbjct: 565 ----TLRPPSRHGHSVV------APGRTAVRARMPALPRR-EGVDKPGFSLATQPRPGAP 613

Query: 239 RSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVA 298
            S   S +        S        PS+P+     +L    E+   +  L P+       
Sbjct: 614 PSASASPAHHASTQGTSHR------PSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPR 667

Query: 299 PDVEGMRSSPGN--KD--------KEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDG 348
           P +   R SP +  +D        K A  +R      A EE     ++ A+   ++LS  
Sbjct: 668 PALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEE-----DSSASAPPSRLSPP 722

Query: 349 NVGSG-ATGSRPEGLAAVDIGSERG---------SSSATSVSAVPADRKSNSTAAQEDAK 398
           + GS     ++P   + +  G + G         + S +++S+  +   S+ T   E A+
Sbjct: 723 HGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAE 782

Query: 399 ADPKGALADYEGKDVATRVGEAWQERPGAPRGG 431
           A    +  D + +D   +     Q     P  G
Sbjct: 783 ASDGESHGDGDREDGGRQAEATAQTLRARPASG 815


>gi|7662228 synaptosomal-associated protein, 91kDa homolog [Homo
           sapiens]
          Length = 907

 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 60/246 (24%), Positives = 98/246 (39%), Gaps = 23/246 (9%)

Query: 349 NVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADY 408
           N GSGA     +   A  + S   + + T  ++ P D  + ++AA   + + P   L D 
Sbjct: 293 NEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDL 352

Query: 409 EGKDVATRVGEAWQERPGAPRGGQ---GD----------PAVPAQ-QPADPSTPERQSSP 454
           +    +     A    P  P GG    GD           +VP++ Q +DP  PE  + P
Sbjct: 353 QPDFSSGGAAAAAAPAPPPPAGGATAWGDLLGEDSLAALSSVPSEAQISDPFAPE-PTPP 411

Query: 455 SGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPG-APRGGQG--DPAVPTQQPA-- 509
           + + ++    +  S+  T           G+A+   PG AP   +G   PA PT   A  
Sbjct: 412 TTTAEIATASASASTTTTVTAVTAEVDLFGDAFAASPGEAPAASEGAAAPATPTPVAAAL 471

Query: 510 DPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQP---HIYIPAPASEL 566
           D  +     +PS        E     ++ P + +  VT TA++  P       PAPA   
Sbjct: 472 DACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAA 531

Query: 567 DSSSTT 572
            +++TT
Sbjct: 532 AAAATT 537


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
            [Homo sapiens]
          Length = 1451

 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 113/517 (21%), Positives = 177/517 (34%), Gaps = 74/517 (14%)

Query: 44   KQDESEGRTIELPSGRSRATSFSSAGEVPKPR----PPSTRAPTGYIIRGVFTKPIDSSS 99
            KQ++SE    E  S  + A+       V K +    P + RAP+         K + +++
Sbjct: 758  KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAA 817

Query: 100  QPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTE 159
            Q +Q+ P     P            GP    S G  + T    +  P     SS      
Sbjct: 818  QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDS 877

Query: 160  EEEEE---EVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIA 216
            EEE E   +V P     Q R + A +    + +PR+ +      K      Q  +     
Sbjct: 878  EEEAETLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933

Query: 217  KRVEVVEEDGPSEKSQDP-----PALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAG 271
               E  + DG +  +        P L    P  + A    T A          +  S + 
Sbjct: 934  SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASEST 993

Query: 272  SQELSSRGEE---IVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGE 328
            ++  SS  E+   I   Q LTP     +V       R +P      A  S+E  R   G+
Sbjct: 994  ARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK 1053

Query: 329  -EAFRAPNTDAA----RSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVP 383
             +   A   D+A     +++  S      G    R   L  V   ++   SS  S     
Sbjct: 1054 KQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDS----- 1108

Query: 384  ADRKSNSTAAQEDAKADPKGALADYEGKDVATRVG---------------EAWQERPGAP 428
             D   +S+ ++ED +  P+GA      K   T VG               E+ ++   AP
Sbjct: 1109 EDSSDSSSGSEEDGEG-PQGA------KSAHTLVGPTPSRTETLVEETAAESSEDDVVAP 1161

Query: 429  R----GGQGDPAV-PAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKV 483
                  G   P + PA   A  +TP+  SSPS S  L  ++        D +GK      
Sbjct: 1162 SQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKD--------DPDGK------ 1207

Query: 484  GEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSP 520
                Q+       G   P    ++ A  +TP++   P
Sbjct: 1208 ----QEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKP 1240



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 92/438 (21%), Positives = 148/438 (33%), Gaps = 72/438 (16%)

Query: 108 ANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVV 167
           A GTP   A+      AG     +   K   +            S +S +   + EEE  
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEED------------SESSSEESSDSEEETP 354

Query: 168 PFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGP 227
              +  Q + S   S V   +AP + S    AA    G T    A   A + E   +   
Sbjct: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSS 414

Query: 228 SEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQI 287
            E   +  A A++ P       G+    RA          + A ++E   +G      + 
Sbjct: 415 EESDSEEEAPAQAKP------SGKAPQVRA----------ASAPAKESPRKGAAPAPPRK 458

Query: 288 LTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSD 347
             P A    V    E  RSS          S E   D     A  A        S Q+  
Sbjct: 459 TGPAAAQVQVGKQEEDSRSS----------SEESDSDREALAAMNAAQVKPLGKSPQVKP 508

Query: 348 GN-VGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALA 406
            + +G G  G   +G   V  G    ++ +  V     D +S+S  + + +  +   A+A
Sbjct: 509 ASTMGMGPLG---KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 565

Query: 407 DYEGKDVATRVGEAWQERP-GAPRGGQGDPAVP------AQQPADPSTPERQSSPSGSEQ 459
             + K     +G   Q +P  +P  G    A P      A++P D S    +SS S   +
Sbjct: 566 PAQEKS----LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 621

Query: 460 ----------------LVRRESCGSSVLTDFEGKDVATKVGEAWQDRPG---APRGGQGD 500
                           + + ++C     T    K    +VG     + G   +P G    
Sbjct: 622 EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA 681

Query: 501 PAVPTQQPADPSTPEQQN 518
            A  TQ+PA+ S+  +++
Sbjct: 682 VAGGTQRPAEDSSSSEES 699



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 121/613 (19%), Positives = 210/613 (34%), Gaps = 147/613 (23%)

Query: 50   GRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFT----------------- 92
            G+  E     S  +S SS GEVP    P+     G I++   T                 
Sbjct: 539  GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 598

Query: 93   ----KPIDSSSQPQQQFPKANGTPKSAASLVRTANAGP----PRPSSSGYKMTTEDYKKL 144
                KP+D+S   ++    A+     AA  +  A A P    P+  +   K  T    K+
Sbjct: 599  VKAEKPMDNSESSEESSDSADSEEAPAA--MTAAQAKPALKIPQTKACPKKTNTTASAKV 656

Query: 145  APYNI-----RRSSTS-----------GDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRT 188
            AP  +     R++ T+           G T+   E+      SD ++ ++  A  V +  
Sbjct: 657  APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK 716

Query: 189  APREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSAD 248
            +  +   V +A+    G   +  AP +  +         +EK +D  +   S   S+S +
Sbjct: 717  SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSES---SEEESDSEE 773

Query: 249  GGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSP 308
               + A     ++   +  +PA ++                        AP  +G  S+P
Sbjct: 774  AAASPAQVKTSVKKTQAKANPAAAR------------------------APSAKGTISAP 809

Query: 309  GNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIG 368
            G                            AA  + Q S   V       +   + A    
Sbjct: 810  GKV------------------------VTAAAQAKQRSPSKVKPPVRNPQNSTVLA---- 841

Query: 369  SERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVAT--RVGEAWQERPG 426
              RG +S  SV    A      T  +ED+ +  + + ++ E + +A     G+  Q R  
Sbjct: 842  --RGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA 899

Query: 427  APRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEA 486
                    PA  + +     TP  ++ PS ++   + +S  SS  +D +G+  A  V  A
Sbjct: 900  LA------PAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAA-VTSA 952

Query: 487  WQDRPGAPRGGQGDPAV---PTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSS-- 541
               +P         P +   P + PA P+    Q   + + +  R    T+R  S  S  
Sbjct: 953  QVIKP---------PLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESED 1003

Query: 542  --------CMV----TVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSS 589
                    C+     T  VT  +  P I   AP + +  +S++K          +S +S 
Sbjct: 1004 EDVIPATQCLTPGIRTNVVTMPTAHPRI---APKASMAGASSSK---------ESSRISD 1051

Query: 590  GKPVSARYSNVSS 602
            GK      + V S
Sbjct: 1052 GKKQEGPATQVDS 1064


>gi|82534351 microtubule-associated protein tau isoform 1 [Homo
           sapiens]
          Length = 758

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 89/465 (19%), Positives = 144/465 (30%), Gaps = 47/465 (10%)

Query: 96  DSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTS 155
           D S +P  +   A  TP +        + G P     G +   + + ++        +  
Sbjct: 54  DGSEEPGSETSDAKSTPTAEDVTAPLVDEGAP-----GKQAAAQPHTEIPEGTTAEEAGI 108

Query: 156 GDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKST-----GPTQET 210
           GDT   E+E      + E +       G LR   P   S+ L +          GP + T
Sbjct: 109 GDTPSLEDE-AAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREAT 167

Query: 211 QAPFIA---------KRVEVVEEDGPSEKSQDPPAL----ARSTPGSNSADGGRTKASRA 257
           + P               E+++     +  Q+ P L     +  PGS            +
Sbjct: 168 RQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDES 227

Query: 258 IWIECLPSMPSPA-GSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAP 316
              +  PS  SPA   +   +   E   +        + L    +  + +     + + P
Sbjct: 228 SPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGP 287

Query: 317 C-SRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGS----GATGSRPEGLAA------- 364
              R   +D   E  F    T   +     S+ ++G     GA G  PE           
Sbjct: 288 SVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTK 347

Query: 365 -VDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQE 423
             D+        A +    P  R     A       D  G+  D + K       +  + 
Sbjct: 348 EADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGS-DDKKAKTSTRSSAKTLKN 406

Query: 424 RPGA----PRGGQGDPAVPAQQPADPST-PERQSSPSGSEQLVRRESCGSSVLTDFEGKD 478
           RP      P  G  DP +   QP+ P+  PE  SSP     +  R     +     +G D
Sbjct: 407 RPCLSPKHPTPGSSDPLI---QPSSPAVCPEPPSSPKHVSSVTSRTGSSGAKEMKLKGAD 463

Query: 479 VATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGS 523
             TK+       P   +G      +P + P  P TP     P  S
Sbjct: 464 GKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKS 508



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 83/412 (20%), Positives = 126/412 (30%), Gaps = 50/412 (12%)

Query: 156 GDTEEEEEEEVVPFSSDEQK---RRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQA 212
           G  EE +E+  V  SS +     + S A  G   +TA RE + +     +   P      
Sbjct: 213 GSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFL 272

Query: 213 PFIAKRVEVVEEDGPS---EKSQDPPAL----ARSTPGSNSADGGRTKASRAIWIECLPS 265
             ++  +   E DGPS    K QD P         TP        +  +   +     P 
Sbjct: 273 SKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKE---QAHSEEHLGRAAFPG 329

Query: 266 MPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDL 325
            P         S GE+     +  P       AP  + +   P  K +    S+    D 
Sbjct: 330 APGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSK----DG 385

Query: 326 AGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPAD 385
            G +  +A  +   RSSA+              P        GS       +S +  P  
Sbjct: 386 TGSDDKKAKTS--TRSSAKTLKNRPCLSPKHPTP--------GSSDPLIQPSSPAVCPEP 435

Query: 386 RKSNSTAAQEDAKADPKGALA-DYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPAD 444
             S    +   ++    GA     +G D  T++       P   +G      +PA+ P  
Sbjct: 436 PSSPKHVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPA 495

Query: 445 PSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVP 504
           P TP     P  S       S GS                      PG P      P++P
Sbjct: 496 PKTPPSSGEPPKSGDRSGYSSPGS----------------------PGTPGSRSRTPSLP 533

Query: 505 TQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQPH 556
           T    +P       +P  S    +    T+ V  P    V   + +T    H
Sbjct: 534 TPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKH 585


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 92/438 (21%), Positives = 148/438 (33%), Gaps = 72/438 (16%)

Query: 108 ANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVV 167
           A GTP   A+      AG     +   K   +            S +S +   + EEE  
Sbjct: 230 AKGTPGKGATPAPPGKAGAVASQTKAGKPEED------------SESSSEESSDSEEETP 277

Query: 168 PFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGP 227
              +  Q + S   S V   +AP + S    AA    G T    A   A + E   +   
Sbjct: 278 AAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSS 337

Query: 228 SEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQI 287
            E   +  A A++ P       G+    RA          + A ++E   +G      + 
Sbjct: 338 EESDSEEEAPAQAKP------SGKAPQVRA----------ASAPAKESPRKGAAPAPPRK 381

Query: 288 LTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSD 347
             P A    V    E  RSS          S E   D     A  A        S Q+  
Sbjct: 382 TGPAAAQVQVGKQEEDSRSS----------SEESDSDREALAAMNAAQVKPLGKSPQVKP 431

Query: 348 GN-VGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALA 406
            + +G G  G   +G   V  G    ++ +  V     D +S+S  + + +  +   A+A
Sbjct: 432 ASTMGMGPLG---KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 488

Query: 407 DYEGKDVATRVGEAWQERP-GAPRGGQGDPAVP------AQQPADPSTPERQSSPSGSEQ 459
             + K     +G   Q +P  +P  G    A P      A++P D S    +SS S   +
Sbjct: 489 PAQEKS----LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 544

Query: 460 ----------------LVRRESCGSSVLTDFEGKDVATKVGEAWQDRPG---APRGGQGD 500
                           + + ++C     T    K    +VG     + G   +P G    
Sbjct: 545 EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA 604

Query: 501 PAVPTQQPADPSTPEQQN 518
            A  TQ+PA+ S+  +++
Sbjct: 605 VAGGTQRPAEDSSSSEES 622



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 124/635 (19%), Positives = 219/635 (34%), Gaps = 121/635 (19%)

Query: 50   GRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFT----------------- 92
            G+  E     S  +S SS GEVP    P+     G I++   T                 
Sbjct: 462  GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 521

Query: 93   ----KPIDSSSQPQQQFPKANGTPKSAASLVRTANAGP----PRPSSSGYKMTTEDYKKL 144
                KP+D+S   ++    A+     AA  +  A A P    P+  +   K  T    K+
Sbjct: 522  VKAEKPMDNSESSEESSDSADSEEAPAA--MTAAQAKPALKIPQTKACPKKTNTTASAKV 579

Query: 145  APYNI-----RRSSTS-----------GDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRT 188
            AP  +     R++ T+           G T+   E+      SD ++ ++  A  V +  
Sbjct: 580  APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK 639

Query: 189  APREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSAD 248
            +  +   V +A+    G   +  AP +  +         +EK +D  +   S   S+S +
Sbjct: 640  SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSES---SEEESDSEE 696

Query: 249  GGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSP 308
               + A     ++   +  +PA ++  S++G         T  A  ++V    +  + SP
Sbjct: 697  AAASPAQVKTSVKKTQAKANPAAARAPSAKG---------TISAPGKVVTAAAQAKQRSP 747

Query: 309  GNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIG 368
                K  P  R  Q                  +S  L+ G          P  + +V   
Sbjct: 748  S---KVKPPVRNPQ------------------NSTVLARG----------PASVPSV--- 773

Query: 369  SERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAP 428
               G + AT+  A     + + ++ +E    +    LA  +      ++  A      +P
Sbjct: 774  ---GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP 830

Query: 429  RGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQ 488
            R G          P+     ++  S S SE+            +D +G+  A  V  A  
Sbjct: 831  RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEE------------SDSDGEAPAA-VTSAQV 877

Query: 489  DRPGA----PRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMV 544
             +P      P      PA    Q    STP +  +   + +    ES    V   + C+ 
Sbjct: 878  IKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLT 937

Query: 545  ----TVTVTATSEQPHIYIPAPASELDSSSTTKGILFV----KEYVNASEVSSGKPVSAR 596
                T  VT  +  P I   AP + +  +S++K    +    K+   A++VS   P S  
Sbjct: 938  PGIRTNVVTMPTAHPRI---APKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLP 994

Query: 597  YSNVS-SIEDSFAMEKKPPCGSTPYSERTTGGICT 630
             +  +  +    A E +PP   T  S      + T
Sbjct: 995  LTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGT 1029



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 115/549 (20%), Positives = 183/549 (33%), Gaps = 100/549 (18%)

Query: 44   KQDESEGRTIELPSGRSRATSFSSAGEVPKPR----PPSTRAPTGYIIRGVFTKPIDSSS 99
            KQ++SE    E  S  + A+       V K +    P + RAP+         K + +++
Sbjct: 681  KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAA 740

Query: 100  QPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTE 159
            Q +Q+ P     P            GP    S G  + T    +  P     SS      
Sbjct: 741  QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDS 800

Query: 160  EEEEE---EVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIA 216
            EEE E   +V P     Q R + A +    + +PR+ +      K      Q  +     
Sbjct: 801  EEEAETLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAAQAGKQDDSG 856

Query: 217  KRVEVVEEDGPSEKSQDP-----PALARSTPGSNSADGGRT--KASRAIWIECLPSMPSP 269
               E  + DG +  +        P L    P  + A    T  +A  A       +  S 
Sbjct: 857  SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASEST 916

Query: 270  AGSQELSSRGEEIV----------RLQILT---------PRAGLRLVAPDVEGMRSSPGN 310
            A S    S  E+++          R  ++T         P+A +   +   E  R S G 
Sbjct: 917  ARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK 976

Query: 311  KDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSE 370
            K +E P ++  +++ A       P T AA                 ++P       +G+ 
Sbjct: 977  K-QEGPATQVSKKNPAS-----LPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTL 1030

Query: 371  RGSS-SATSVSAV--------------PADRKSNSTAAQEDAKADPKGALADYEG----K 411
              +S  +TSV A                A +   S+   ED+     G+  D EG    K
Sbjct: 1031 PATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAK 1090

Query: 412  DVATRVG---------------EAWQERPGAPR----GGQGDPAV-PAQQPADPSTPERQ 451
               T VG               E+ ++   AP      G   P + PA   A  +TP+  
Sbjct: 1091 SAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLD 1150

Query: 452  SSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADP 511
            SSPS S  L  ++        D +GK          Q+       G   P    ++ A  
Sbjct: 1151 SSPSVSSTLAAKD--------DPDGK----------QEAKPQQAAGMLSPKTGGKEAASG 1192

Query: 512  STPEQQNSP 520
            +TP++   P
Sbjct: 1193 TTPQKSRKP 1201


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 92/438 (21%), Positives = 148/438 (33%), Gaps = 72/438 (16%)

Query: 108 ANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVV 167
           A GTP   A+      AG     +   K   +            S +S +   + EEE  
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEED------------SESSSEESSDSEEETP 354

Query: 168 PFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGP 227
              +  Q + S   S V   +AP + S    AA    G T    A   A + E   +   
Sbjct: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSS 414

Query: 228 SEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQI 287
            E   +  A A++ P       G+    RA          + A ++E   +G      + 
Sbjct: 415 EESDSEEEAPAQAKP------SGKAPQVRA----------ASAPAKESPRKGAAPAPPRK 458

Query: 288 LTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSD 347
             P A    V    E  RSS          S E   D     A  A        S Q+  
Sbjct: 459 TGPAAAQVQVGKQEEDSRSS----------SEESDSDREALAAMNAAQVKPLGKSPQVKP 508

Query: 348 GN-VGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALA 406
            + +G G  G   +G   V  G    ++ +  V     D +S+S  + + +  +   A+A
Sbjct: 509 ASTMGMGPLG---KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 565

Query: 407 DYEGKDVATRVGEAWQERP-GAPRGGQGDPAVP------AQQPADPSTPERQSSPSGSEQ 459
             + K     +G   Q +P  +P  G    A P      A++P D S    +SS S   +
Sbjct: 566 PAQEKS----LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 621

Query: 460 ----------------LVRRESCGSSVLTDFEGKDVATKVGEAWQDRPG---APRGGQGD 500
                           + + ++C     T    K    +VG     + G   +P G    
Sbjct: 622 EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA 681

Query: 501 PAVPTQQPADPSTPEQQN 518
            A  TQ+PA+ S+  +++
Sbjct: 682 VAGGTQRPAEDSSSSEES 699



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 124/635 (19%), Positives = 219/635 (34%), Gaps = 121/635 (19%)

Query: 50   GRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFT----------------- 92
            G+  E     S  +S SS GEVP    P+     G I++   T                 
Sbjct: 539  GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 598

Query: 93   ----KPIDSSSQPQQQFPKANGTPKSAASLVRTANAGP----PRPSSSGYKMTTEDYKKL 144
                KP+D+S   ++    A+     AA  +  A A P    P+  +   K  T    K+
Sbjct: 599  VKAEKPMDNSESSEESSDSADSEEAPAA--MTAAQAKPALKIPQTKACPKKTNTTASAKV 656

Query: 145  APYNI-----RRSSTS-----------GDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRT 188
            AP  +     R++ T+           G T+   E+      SD ++ ++  A  V +  
Sbjct: 657  APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK 716

Query: 189  APREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSAD 248
            +  +   V +A+    G   +  AP +  +         +EK +D  +   S   S+S +
Sbjct: 717  SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSES---SEEESDSEE 773

Query: 249  GGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSP 308
               + A     ++   +  +PA ++  S++G         T  A  ++V    +  + SP
Sbjct: 774  AAASPAQVKTSVKKTQAKANPAAARAPSAKG---------TISAPGKVVTAAAQAKQRSP 824

Query: 309  GNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIG 368
                K  P  R  Q                  +S  L+ G          P  + +V   
Sbjct: 825  S---KVKPPVRNPQ------------------NSTVLARG----------PASVPSV--- 850

Query: 369  SERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAP 428
               G + AT+  A     + + ++ +E    +    LA  +      ++  A      +P
Sbjct: 851  ---GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP 907

Query: 429  RGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQ 488
            R G          P+     ++  S S SE+            +D +G+  A  V  A  
Sbjct: 908  RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEE------------SDSDGEAPAA-VTSAQV 954

Query: 489  DRPGA----PRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMV 544
             +P      P      PA    Q    STP +  +   + +    ES    V   + C+ 
Sbjct: 955  IKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLT 1014

Query: 545  ----TVTVTATSEQPHIYIPAPASELDSSSTTKGILFV----KEYVNASEVSSGKPVSAR 596
                T  VT  +  P I   AP + +  +S++K    +    K+   A++VS   P S  
Sbjct: 1015 PGIRTNVVTMPTAHPRI---APKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLP 1071

Query: 597  YSNVS-SIEDSFAMEKKPPCGSTPYSERTTGGICT 630
             +  +  +    A E +PP   T  S      + T
Sbjct: 1072 LTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGT 1106



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 111/543 (20%), Positives = 184/543 (33%), Gaps = 89/543 (16%)

Query: 44   KQDESEGRTIELPSGRSRATSFSSAGEVPKPR----PPSTRAPTGYIIRGVFTKPIDSSS 99
            KQ++SE    E  S  + A+       V K +    P + RAP+         K + +++
Sbjct: 758  KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAA 817

Query: 100  QPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTE 159
            Q +Q+ P     P            GP    S G  + T    +  P     SS      
Sbjct: 818  QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDS 877

Query: 160  EEEEE---EVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIA 216
            EEE E   +V P     Q R + A +    + +PR+ +      K      Q  +     
Sbjct: 878  EEEAETLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933

Query: 217  KRVEVVEEDGPSEKSQDP-----PALARSTPGSNSADGGRT--KASRAIWIECLPSMPSP 269
               E  + DG +  +        P L    P  + A    T  +A  A       +  S 
Sbjct: 934  SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASEST 993

Query: 270  AGSQELSSRGEEIV----------RLQILT---------PRAGLRLVAPDVEGMRSSPGN 310
            A S    S  E+++          R  ++T         P+A +   +   E  R S G 
Sbjct: 994  ARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK 1053

Query: 311  KD--------KEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGAT--GSRPE 360
            K         K+ P S  L +      A +A       +  Q S G   +  T   + P+
Sbjct: 1054 KQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQ 1113

Query: 361  GLAAVDIGSER----------GSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEG 410
              +    G+ +           ++ A   S    D   +S+ ++ED +  P+GA + +  
Sbjct: 1114 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEG-PQGAKSAHTL 1172

Query: 411  KDVATRV--------GEAWQERPGAPR----GGQGDPAV-PAQQPADPSTPERQSSPSGS 457
                +R          E+ ++   AP      G   P + PA   A  +TP+  SSPS S
Sbjct: 1173 GPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVS 1232

Query: 458  EQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQ 517
              L  ++        D +GK          Q+       G   P    ++ A  +TP++ 
Sbjct: 1233 STLAAKD--------DPDGK----------QEAKPQQAAGMLSPKTGGKEAASGTTPQKS 1274

Query: 518  NSP 520
              P
Sbjct: 1275 RKP 1277


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 92/438 (21%), Positives = 148/438 (33%), Gaps = 72/438 (16%)

Query: 108 ANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVV 167
           A GTP   A+      AG     +   K   +            S +S +   + EEE  
Sbjct: 230 AKGTPGKGATPAPPGKAGAVASQTKAGKPEED------------SESSSEESSDSEEETP 277

Query: 168 PFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGP 227
              +  Q + S   S V   +AP + S    AA    G T    A   A + E   +   
Sbjct: 278 AAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSS 337

Query: 228 SEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQI 287
            E   +  A A++ P       G+    RA          + A ++E   +G      + 
Sbjct: 338 EESDSEEEAPAQAKP------SGKAPQVRA----------ASAPAKESPRKGAAPAPPRK 381

Query: 288 LTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSD 347
             P A    V    E  RSS          S E   D     A  A        S Q+  
Sbjct: 382 TGPAAAQVQVGKQEEDSRSS----------SEESDSDREALAAMNAAQVKPLGKSPQVKP 431

Query: 348 GN-VGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALA 406
            + +G G  G   +G   V  G    ++ +  V     D +S+S  + + +  +   A+A
Sbjct: 432 ASTMGMGPLG---KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 488

Query: 407 DYEGKDVATRVGEAWQERP-GAPRGGQGDPAVP------AQQPADPSTPERQSSPSGSEQ 459
             + K     +G   Q +P  +P  G    A P      A++P D S    +SS S   +
Sbjct: 489 PAQEKS----LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 544

Query: 460 ----------------LVRRESCGSSVLTDFEGKDVATKVGEAWQDRPG---APRGGQGD 500
                           + + ++C     T    K    +VG     + G   +P G    
Sbjct: 545 EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA 604

Query: 501 PAVPTQQPADPSTPEQQN 518
            A  TQ+PA+ S+  +++
Sbjct: 605 VAGGTQRPAEDSSSSEES 622



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 124/635 (19%), Positives = 219/635 (34%), Gaps = 121/635 (19%)

Query: 50   GRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFT----------------- 92
            G+  E     S  +S SS GEVP    P+     G I++   T                 
Sbjct: 462  GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 521

Query: 93   ----KPIDSSSQPQQQFPKANGTPKSAASLVRTANAGP----PRPSSSGYKMTTEDYKKL 144
                KP+D+S   ++    A+     AA  +  A A P    P+  +   K  T    K+
Sbjct: 522  VKAEKPMDNSESSEESSDSADSEEAPAA--MTAAQAKPALKIPQTKACPKKTNTTASAKV 579

Query: 145  APYNI-----RRSSTS-----------GDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRT 188
            AP  +     R++ T+           G T+   E+      SD ++ ++  A  V +  
Sbjct: 580  APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK 639

Query: 189  APREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSAD 248
            +  +   V +A+    G   +  AP +  +         +EK +D  +   S   S+S +
Sbjct: 640  SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSES---SEEESDSEE 696

Query: 249  GGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSP 308
               + A     ++   +  +PA ++  S++G         T  A  ++V    +  + SP
Sbjct: 697  AAASPAQVKTSVKKTQAKANPAAARAPSAKG---------TISAPGKVVTAAAQAKQRSP 747

Query: 309  GNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIG 368
                K  P  R  Q                  +S  L+ G          P  + +V   
Sbjct: 748  S---KVKPPVRNPQ------------------NSTVLARG----------PASVPSV--- 773

Query: 369  SERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAP 428
               G + AT+  A     + + ++ +E    +    LA  +      ++  A      +P
Sbjct: 774  ---GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP 830

Query: 429  RGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQ 488
            R G          P+     ++  S S SE+            +D +G+  A  V  A  
Sbjct: 831  RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEE------------SDSDGEAPAA-VTSAQV 877

Query: 489  DRPGA----PRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMV 544
             +P      P      PA    Q    STP +  +   + +    ES    V   + C+ 
Sbjct: 878  IKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLT 937

Query: 545  ----TVTVTATSEQPHIYIPAPASELDSSSTTKGILFV----KEYVNASEVSSGKPVSAR 596
                T  VT  +  P I   AP + +  +S++K    +    K+   A++VS   P S  
Sbjct: 938  PGIRTNVVTMPTAHPRI---APKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLP 994

Query: 597  YSNVS-SIEDSFAMEKKPPCGSTPYSERTTGGICT 630
             +  +  +    A E +PP   T  S      + T
Sbjct: 995  LTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGT 1029



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 111/543 (20%), Positives = 184/543 (33%), Gaps = 89/543 (16%)

Query: 44   KQDESEGRTIELPSGRSRATSFSSAGEVPKPR----PPSTRAPTGYIIRGVFTKPIDSSS 99
            KQ++SE    E  S  + A+       V K +    P + RAP+         K + +++
Sbjct: 681  KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAA 740

Query: 100  QPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTE 159
            Q +Q+ P     P            GP    S G  + T    +  P     SS      
Sbjct: 741  QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDS 800

Query: 160  EEEEE---EVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIA 216
            EEE E   +V P     Q R + A +    + +PR+ +      K      Q  +     
Sbjct: 801  EEEAETLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAAQAGKQDDSG 856

Query: 217  KRVEVVEEDGPSEKSQDP-----PALARSTPGSNSADGGRT--KASRAIWIECLPSMPSP 269
               E  + DG +  +        P L    P  + A    T  +A  A       +  S 
Sbjct: 857  SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASEST 916

Query: 270  AGSQELSSRGEEIV----------RLQILT---------PRAGLRLVAPDVEGMRSSPGN 310
            A S    S  E+++          R  ++T         P+A +   +   E  R S G 
Sbjct: 917  ARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK 976

Query: 311  KD--------KEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGAT--GSRPE 360
            K         K+ P S  L +      A +A       +  Q S G   +  T   + P+
Sbjct: 977  KQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQ 1036

Query: 361  GLAAVDIGSER----------GSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEG 410
              +    G+ +           ++ A   S    D   +S+ ++ED +  P+GA + +  
Sbjct: 1037 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEG-PQGAKSAHTL 1095

Query: 411  KDVATRV--------GEAWQERPGAPR----GGQGDPAV-PAQQPADPSTPERQSSPSGS 457
                +R          E+ ++   AP      G   P + PA   A  +TP+  SSPS S
Sbjct: 1096 GPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVS 1155

Query: 458  EQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQ 517
              L  ++        D +GK          Q+       G   P    ++ A  +TP++ 
Sbjct: 1156 STLAAKD--------DPDGK----------QEAKPQQAAGMLSPKTGGKEAASGTTPQKS 1197

Query: 518  NSP 520
              P
Sbjct: 1198 RKP 1200


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 92/438 (21%), Positives = 148/438 (33%), Gaps = 72/438 (16%)

Query: 108 ANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVV 167
           A GTP   A+      AG     +   K   +            S +S +   + EEE  
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEED------------SESSSEESSDSEEETP 354

Query: 168 PFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGP 227
              +  Q + S   S V   +AP + S    AA    G T    A   A + E   +   
Sbjct: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSS 414

Query: 228 SEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQI 287
            E   +  A A++ P       G+    RA          + A ++E   +G      + 
Sbjct: 415 EESDSEEEAPAQAKP------SGKAPQVRA----------ASAPAKESPRKGAAPAPPRK 458

Query: 288 LTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSD 347
             P A    V    E  RSS          S E   D     A  A        S Q+  
Sbjct: 459 TGPAAAQVQVGKQEEDSRSS----------SEESDSDREALAAMNAAQVKPLGKSPQVKP 508

Query: 348 GN-VGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALA 406
            + +G G  G   +G   V  G    ++ +  V     D +S+S  + + +  +   A+A
Sbjct: 509 ASTMGMGPLG---KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 565

Query: 407 DYEGKDVATRVGEAWQERP-GAPRGGQGDPAVP------AQQPADPSTPERQSSPSGSEQ 459
             + K     +G   Q +P  +P  G    A P      A++P D S    +SS S   +
Sbjct: 566 PAQEKS----LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 621

Query: 460 ----------------LVRRESCGSSVLTDFEGKDVATKVGEAWQDRPG---APRGGQGD 500
                           + + ++C     T    K    +VG     + G   +P G    
Sbjct: 622 EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA 681

Query: 501 PAVPTQQPADPSTPEQQN 518
            A  TQ+PA+ S+  +++
Sbjct: 682 VAGGTQRPAEDSSSSEES 699



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 118/588 (20%), Positives = 204/588 (34%), Gaps = 57/588 (9%)

Query: 9   RTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRSRATSFSSA 68
           R    P PPG+     V K    +       S      E E      PSG++     +SA
Sbjct: 383 RKGAAPAPPGKTGPA-VAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASA 441

Query: 69  GEVPKPR------PPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVRTA 122
                PR      PP    P    ++ V  +  DS S  ++            A+ V+  
Sbjct: 442 PAKESPRKGAAPAPPRKTGPAAAQVQ-VGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500

Query: 123 NAGPP-RPSSS-GYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEA 180
              P  +P+S+ G     +    + P  +  ++ S    + EE+     S    +  S++
Sbjct: 501 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED-----SESSSEESSDS 555

Query: 181 ASG-VLRRTAPREHSYV--LSAAKKSTGPTQ--ETQAPFIAKRVEVVEEDGPSEKSQDPP 235
           + G V    AP +   +  +  AK ++ P +    +A  +A +V+  +    SE S++  
Sbjct: 556 SDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEE-- 613

Query: 236 ALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLR 295
             +  +  S  A    T A     ++   +   P  +   +S     VR+    PR    
Sbjct: 614 --SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGT 671

Query: 296 LVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARS---------SAQLS 346
             +P       + G +      S   + D   E+   A     A+S         ++   
Sbjct: 672 ATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPV 731

Query: 347 DGNVGSGATGSRP--EGLAAVDIGSERGSSSATS--------VSAVPADRKSNSTAAQED 396
            G++G G     P   G     + +E+   S +S         +A PA  K++    Q  
Sbjct: 732 KGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQ-- 789

Query: 397 AKADPKGALA-------DYEGKDVATRVGEAWQERPGAPRGGQGDP---AVPAQQPADPS 446
           AKA+P  A A          GK V T   +A Q  P   +    +P    V A+ PA   
Sbjct: 790 AKANPAAARAPSAKGTISAPGK-VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 848

Query: 447 TPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQ 506
           +  +  + +   Q    E  GSS       ++  T        +    R     PA  + 
Sbjct: 849 SVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALA-PAKESP 907

Query: 507 QPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQ 554
           +     TP  +  PS ++   + +S +S   S S       VT+  +Q
Sbjct: 908 RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQ 955


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 135/617 (21%), Positives = 210/617 (34%), Gaps = 119/617 (19%)

Query: 59  RSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASL 118
           R  A   S A  +PK   P   A +  + R    + +DSS  P+Q     +G P      
Sbjct: 54  RQIAAVMSRAQGLPKGSVPPAAAESPSMHR---KQELDSSHPPKQ-----SGRPPD---- 101

Query: 119 VRTANAGPPRPSSSGYKM--TTEDYK---KL-----APYNIRRSSTSGDTEEEEEEEVVP 168
                  P RP+  G     TT+ ++   KL     +  +++ S +  D +EE +  ++P
Sbjct: 102 -------PGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMP 154

Query: 169 FSSDEQKRRSEAASGVLRRTAP---------------REHSYVLSAAKKSTG----PTQE 209
               E    S A S V+ +  P               ++   V     K  G    P Q+
Sbjct: 155 GFLSEVNALS-AVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQ 213

Query: 210 TQAPFIAKRV----EVVEEDGP--SEKSQDPPALARSTPGSNSADGGRTKASRAIWIECL 263
                I K+     + +++DG   S  SQ P  +    PG+     G T+  +    +  
Sbjct: 214 QPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAK-- 271

Query: 264 PSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRS-SPGNKDKEAPCSRELQ 322
             +P    +    ++  +IVR + + P     L +P    ++  +PG    + P   + Q
Sbjct: 272 --LPLQRDASRPQTKQADIVRGESVKPS----LPSPSKPPIQQPTPGKPPAQQPGHEKSQ 325

Query: 323 RDLAGEEAFRAPNTDAARSSAQLSDGNV---GSGATGSRPEGLA---AVDIGSERGSSSA 376
              A   A  +  T             V   G+    ++P G A   A   GSE+ SS  
Sbjct: 326 PGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQ 385

Query: 377 TSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPA 436
               A+        T AQ+   A P         + V T    A Q    +P    G   
Sbjct: 386 PGPKALAQPPGVGKTPAQQPGPAKPPT-------QQVGTPKPLAQQPGLQSPAKAPGPTK 438

Query: 437 VPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRG 496
            P QQP     P +Q+ P  +       +   S L     K    + G A   +P   + 
Sbjct: 439 TPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG-PAKPPPQQPGPA---KPPPQQP 494

Query: 497 GQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQPH 556
           G   P  P+QQP     P QQ  P+               + PS           S +P 
Sbjct: 495 GSAKP--PSQQPGSTKPPPQQPGPAKPS-----PQQPGSTKPPSQ-------QPGSAKPS 540

Query: 557 IYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNVSSIEDSFAMEKKPPCG 616
              P+PA      ST             S+  SGKP+     + S+        K+PP  
Sbjct: 541 AQQPSPAKPSAQQSTKP----------VSQTGSGKPLQPPTVSPSA--------KQPPSQ 582

Query: 617 STPYSERTTGGICTYCN 633
             P +      IC  CN
Sbjct: 583 GLPKT------ICPLCN 593



 Score = 33.5 bits (75), Expect = 0.67
 Identities = 50/238 (21%), Positives = 87/238 (36%), Gaps = 16/238 (6%)

Query: 11   KGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRSRATSFSSAGE 70
            K +P PP   + + V +  K +T  + DKS  +   + +       +G S     SS GE
Sbjct: 1318 KEQPQPPCTAKPDQV-EPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGE 1376

Query: 71   VPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPS 130
            +P   P   +     I++G+        S P    P      +S    +  A A      
Sbjct: 1377 IPSLIPTDEKD----ILKGLKKDSFSQESSPSS--PSDLAKLESTVLSILEAQASTLADE 1430

Query: 131  SSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAP 190
             S  K    +     P +  ++ +  +T E      +  S +E K   E      ++ + 
Sbjct: 1431 KSEKKTQPHEVSPEQPKDQEKTQSLSETLE------ITISEEEIKESQEERKDTFKKDSQ 1484

Query: 191  REHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSAD 248
            ++        +KS      T      +  + VEE   SE S  P    R++ GS+S+D
Sbjct: 1485 QDIPSSKDHKEKSEFVDDITTR---REPYDSVEESSESENSPVPQRKRRTSVGSSSSD 1539



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 79/393 (20%), Positives = 126/393 (32%), Gaps = 64/393 (16%)

Query: 72  PKPRPPSTRAPTGYIIRGVFTKPIDSSS-QPQQQFPKANGTPKSAASLVRTANAGPPRPS 130
           P P  P  +  T  +     T  +  SS QPQQ  PK +  PK   S        PP   
Sbjct: 652 PVPSSPQPKLKTAPVTT---TSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVK 708

Query: 131 SSGYKMTTEDYKKLAPY--NIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRT 188
                 +     K  P   ++ + +   +     E++  P + D+ K+       +++ T
Sbjct: 709 QPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPK-----MVKPT 763

Query: 189 APREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSAD 248
                S   SA  K   P+ + Q+    K    ++ D        PP   + +P  + A 
Sbjct: 764 TDLVSS--SSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAI 821

Query: 249 GGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSP 308
                 S+ I      S P P+   +   + + + + +            P     + SP
Sbjct: 822 PRPASDSKII------SHPGPSSESKGQKQVDPVQKKE-----------EPKKAQTKMSP 864

Query: 309 GNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIG 368
               K  P                +P     R +A         G T   P+        
Sbjct: 865 KPDAKPMPKG--------------SPTPPGPRPTA---------GQTVPTPQQSPKPQEQ 901

Query: 369 SERGSSSATSVSAVPADRKSNSTAAQE--DAKADPKGALADYEGKDVATRVGEAWQERPG 426
           S R S +  S++  P   KS  T  QE    K    GA    +  ++ +  G+     PG
Sbjct: 902 SRRFSLNLGSITDAP---KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQ-----PG 953

Query: 427 APRGGQGDPAVPAQQPADPSTPERQSSPSGSEQ 459
            P    G  A   Q PA    P  Q  P  + Q
Sbjct: 954 -PHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQ 985


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 135/617 (21%), Positives = 210/617 (34%), Gaps = 119/617 (19%)

Query: 59  RSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASL 118
           R  A   S A  +PK   P   A +  + R    + +DSS  P+Q     +G P      
Sbjct: 54  RQIAAVMSRAQGLPKGSVPPAAAESPSMHR---KQELDSSHPPKQ-----SGRPPD---- 101

Query: 119 VRTANAGPPRPSSSGYKM--TTEDYK---KL-----APYNIRRSSTSGDTEEEEEEEVVP 168
                  P RP+  G     TT+ ++   KL     +  +++ S +  D +EE +  ++P
Sbjct: 102 -------PGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMP 154

Query: 169 FSSDEQKRRSEAASGVLRRTAP---------------REHSYVLSAAKKSTG----PTQE 209
               E    S A S V+ +  P               ++   V     K  G    P Q+
Sbjct: 155 GFLSEVNALS-AVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQ 213

Query: 210 TQAPFIAKRV----EVVEEDGP--SEKSQDPPALARSTPGSNSADGGRTKASRAIWIECL 263
                I K+     + +++DG   S  SQ P  +    PG+     G T+  +    +  
Sbjct: 214 QPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAK-- 271

Query: 264 PSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRS-SPGNKDKEAPCSRELQ 322
             +P    +    ++  +IVR + + P     L +P    ++  +PG    + P   + Q
Sbjct: 272 --LPLQRDASRPQTKQADIVRGESVKPS----LPSPSKPPIQQPTPGKPPAQQPGHEKSQ 325

Query: 323 RDLAGEEAFRAPNTDAARSSAQLSDGNV---GSGATGSRPEGLA---AVDIGSERGSSSA 376
              A   A  +  T             V   G+    ++P G A   A   GSE+ SS  
Sbjct: 326 PGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQ 385

Query: 377 TSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPA 436
               A+        T AQ+   A P         + V T    A Q    +P    G   
Sbjct: 386 PGPKALAQPPGVGKTPAQQPGPAKPPT-------QQVGTPKPLAQQPGLQSPAKAPGPTK 438

Query: 437 VPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRG 496
            P QQP     P +Q+ P  +       +   S L     K    + G A   +P   + 
Sbjct: 439 TPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG-PAKPPPQQPGPA---KPPPQQP 494

Query: 497 GQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQPH 556
           G   P  P+QQP     P QQ  P+               + PS           S +P 
Sbjct: 495 GSAKP--PSQQPGSTKPPPQQPGPAKPS-----PQQPGSTKPPSQ-------QPGSAKPS 540

Query: 557 IYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNVSSIEDSFAMEKKPPCG 616
              P+PA      ST             S+  SGKP+     + S+        K+PP  
Sbjct: 541 AQQPSPAKPSAQQSTKP----------VSQTGSGKPLQPPTVSPSA--------KQPPSQ 582

Query: 617 STPYSERTTGGICTYCN 633
             P +      IC  CN
Sbjct: 583 GLPKT------ICPLCN 593



 Score = 33.5 bits (75), Expect = 0.67
 Identities = 50/238 (21%), Positives = 87/238 (36%), Gaps = 16/238 (6%)

Query: 11   KGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRSRATSFSSAGE 70
            K +P PP   + + V +  K +T  + DKS  +   + +       +G S     SS GE
Sbjct: 1318 KEQPQPPCTAKPDQV-EPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGE 1376

Query: 71   VPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPS 130
            +P   P   +     I++G+        S P    P      +S    +  A A      
Sbjct: 1377 IPSLIPTDEKD----ILKGLKKDSFSQESSPSS--PSDLAKLESTVLSILEAQASTLADE 1430

Query: 131  SSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAP 190
             S  K    +     P +  ++ +  +T E      +  S +E K   E      ++ + 
Sbjct: 1431 KSEKKTQPHEVSPEQPKDQEKTQSLSETLE------ITISEEEIKESQEERKDTFKKDSQ 1484

Query: 191  REHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSAD 248
            ++        +KS      T      +  + VEE   SE S  P    R++ GS+S+D
Sbjct: 1485 QDIPSSKDHKEKSEFVDDITTR---REPYDSVEESSESENSPVPQRKRRTSVGSSSSD 1539



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 79/393 (20%), Positives = 126/393 (32%), Gaps = 64/393 (16%)

Query: 72  PKPRPPSTRAPTGYIIRGVFTKPIDSSS-QPQQQFPKANGTPKSAASLVRTANAGPPRPS 130
           P P  P  +  T  +     T  +  SS QPQQ  PK +  PK   S        PP   
Sbjct: 652 PVPSSPQPKLKTAPVTT---TSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVK 708

Query: 131 SSGYKMTTEDYKKLAPY--NIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRT 188
                 +     K  P   ++ + +   +     E++  P + D+ K+       +++ T
Sbjct: 709 QPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPK-----MVKPT 763

Query: 189 APREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSAD 248
                S   SA  K   P+ + Q+    K    ++ D        PP   + +P  + A 
Sbjct: 764 TDLVSS--SSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAI 821

Query: 249 GGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSP 308
                 S+ I      S P P+   +   + + + + +            P     + SP
Sbjct: 822 PRPASDSKII------SHPGPSSESKGQKQVDPVQKKE-----------EPKKAQTKMSP 864

Query: 309 GNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIG 368
               K  P                +P     R +A         G T   P+        
Sbjct: 865 KPDAKPMPKG--------------SPTPPGPRPTA---------GQTVPTPQQSPKPQEQ 901

Query: 369 SERGSSSATSVSAVPADRKSNSTAAQE--DAKADPKGALADYEGKDVATRVGEAWQERPG 426
           S R S +  S++  P   KS  T  QE    K    GA    +  ++ +  G+     PG
Sbjct: 902 SRRFSLNLGSITDAP---KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQ-----PG 953

Query: 427 APRGGQGDPAVPAQQPADPSTPERQSSPSGSEQ 459
            P    G  A   Q PA    P  Q  P  + Q
Sbjct: 954 -PHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQ 985


>gi|178557734 microtubule-associated protein tau isoform 6 [Homo
           sapiens]
          Length = 776

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 93/480 (19%), Positives = 152/480 (31%), Gaps = 52/480 (10%)

Query: 96  DSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTS 155
           D S +P  +   A  TP +        + G P     G +   + + ++        +  
Sbjct: 54  DGSEEPGSETSDAKSTPTAEDVTAPLVDEGAP-----GKQAAAQPHTEIPEGTTAEEAGI 108

Query: 156 GDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKST-----GPTQET 210
           GDT   E+E      + E +       G LR   P   S+ L +          GP + T
Sbjct: 109 GDTPSLEDE-AAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREAT 167

Query: 211 QAPFIA---------KRVEVVEEDGPSEKSQDPPAL----ARSTPGSNSADGGRTKASRA 257
           + P               E+++     +  Q+ P L     +  PGS            +
Sbjct: 168 RQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDES 227

Query: 258 IWIECLPSMPSPA-GSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAP 316
              +  PS  SPA   +   +   E   +        + L    +  + +     + + P
Sbjct: 228 SPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGP 287

Query: 317 C-SRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGS----GATGSRPEGLAA------- 364
              R   +D   E  F    T   +     S+ ++G     GA G  PE           
Sbjct: 288 SVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTK 347

Query: 365 -VDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQE 423
             D+        A +    P  R     A       D  G+  D + K       +  + 
Sbjct: 348 EADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGS-DDKKAKTSTRSSAKTLKN 406

Query: 424 RPGA----PRGGQGDPAVPAQQPADPST-PERQSSPSGSEQLVRRESCGSSVLTDFEGKD 478
           RP      P  G  DP +   QP+ P+  PE  SSP     +  R     +     +G D
Sbjct: 407 RPCLSPKHPTPGSSDPLI---QPSSPAVCPEPPSSPKHVSSVTSRTGSSGAKEMKLKGAD 463

Query: 479 VATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRS 538
             TK+       P   +G      +P + P  P TP     PS + + V+R    +  RS
Sbjct: 464 GKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTP-----PSSATKQVQRRPPPAGPRS 518



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 84/412 (20%), Positives = 132/412 (32%), Gaps = 32/412 (7%)

Query: 156 GDTEEEEEEEVVPFSSDEQK---RRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQA 212
           G  EE +E+  V  SS +     + S A  G   +TA RE + +     +   P      
Sbjct: 213 GSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFL 272

Query: 213 PFIAKRVEVVEEDGPS---EKSQDPPAL----ARSTPGSNSADGGRTKASRAIWIECLPS 265
             ++  +   E DGPS    K QD P         TP        +  +   +     P 
Sbjct: 273 SKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKE---QAHSEEHLGRAAFPG 329

Query: 266 MPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDL 325
            P         S GE+     +  P       AP  + +   P  K +    S+    D 
Sbjct: 330 APGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSK----DG 385

Query: 326 AGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPAD 385
            G +  +A  +   RSSA+              P        GS       +S +  P  
Sbjct: 386 TGSDDKKAKTS--TRSSAKTLKNRPCLSPKHPTP--------GSSDPLIQPSSPAVCPEP 435

Query: 386 RKSNSTAAQEDAKADPKGALA-DYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPAD 444
             S    +   ++    GA     +G D  T++       P   +G      +PA+ P  
Sbjct: 436 PSSPKHVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPA 495

Query: 445 PSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVP 504
           P TP      S ++Q+ RR           E      + G +    PG P      P++P
Sbjct: 496 PKTPPS----SATKQVQRRPPPAGPRSERGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLP 551

Query: 505 TQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQPH 556
           T    +P       +P  S    +    T+ V  P    V   + +T    H
Sbjct: 552 TPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKH 603


>gi|163310741 LIM and calponin homology domains 1 isoform a [Homo
            sapiens]
          Length = 1083

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 7/79 (8%)

Query: 614  PCGSTPYSE---RTTGG--ICTYCNREIRDCPKITLEHLGICCHEYCFKCGICSKPMGDL 668
            PC  TP  +   R+  G  +C+ C   +     + +E L +  H  CF+CGIC   +GD 
Sbjct: 993  PCSPTPPGQSPNRSISGKKLCSSCGLPLGKGAAMIIETLNLYFHIQCFRCGICKGQLGDA 1052

Query: 669  LD--QIFIHRDTIHCGKCY 685
            +    + I    ++C  CY
Sbjct: 1053 VSGTDVRIRNGLLNCNDCY 1071


>gi|239742243 PREDICTED: HPX-153 homeobox [Homo sapiens]
          Length = 411

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 62/218 (28%), Positives = 77/218 (35%), Gaps = 38/218 (17%)

Query: 264 PSMPSPAGSQELSSRGEEIVRLQIL-----------TPRAGLRLVAPDVE-----GMRSS 307
           P  P+PA S     R EE+ R  +             P AG    A + E     G  S 
Sbjct: 81  PCAPAPAASGR-PPRAEELERRALAGAGGVGAAGAEPPNAGDPFKAGEAETNDTNGYSSG 139

Query: 308 PGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDI 367
            G     A    E+  D   +E   AP T+AAR + +   G  G GA GS  +G A  D 
Sbjct: 140 GGGHSPSADSGDEVPDDEDDDED-EAPETEAARGAEEARGGGGGLGARGSGCQGAAETD- 197

Query: 368 GSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGA 427
                S  AT   A     + NS  AQ      P GA A   G    T  G A   +P  
Sbjct: 198 ----ASPGATVDEAAAPGPRENSPVAQ----GPPGGAAA--PGGAGTTPQGTATAAKPKR 247

Query: 428 PRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRES 465
            R G    +           P R  +    EQLV  E+
Sbjct: 248 KRTGSDSKS---------GKPRRARTAFTYEQLVALEN 276


>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
          Length = 1312

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 104/453 (22%), Positives = 140/453 (30%), Gaps = 72/453 (15%)

Query: 50  GRTIELPSGRSRAT-------SFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQ 102
           G+T+   S  SR T            G  P P P S  +            P  SSS P 
Sbjct: 157 GKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPS---------PSPSSSSPS 207

Query: 103 QQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDT---- 158
              P     P  A    R     P  P+   Y       +K  P+    S+ S       
Sbjct: 208 PPPPPPPPAPP-APPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPS 266

Query: 159 -EEEEEEEVVPFSSDEQK-----------RRSEAASGVLRRTAPREHSYVLSAAKKSTGP 206
            EEEEEEE      +E +           R SE  +G+    +  +      + +    P
Sbjct: 267 PEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQP 326

Query: 207 TQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSM 266
           TQ T AP    +V+    DG   +          T      +G  +          LP  
Sbjct: 327 TQPTPAPGTPPQVDSTRADGAMRRR----VFVVGTEAEACREGKVSVEVVTAGGAALPPP 382

Query: 267 PSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLA 326
             P G  E+     EIV+ +   PR  L L  P     R +P      A  +    + L 
Sbjct: 383 LLPPGDSEIEE--GEIVQPE-EEPRLALSLFRPGGRAARPTP------AASATPTAQPLP 433

Query: 327 GEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPAD- 385
              A RAP  D   S    SDG           EG   VD+G    +  A        D 
Sbjct: 434 QPPAPRAPEGDDFLSLHAESDG-----------EGALQVDLGEPAPAPPAADSRWGGLDL 482

Query: 386 ------------RKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQG 433
                       R+ + + A   A A   G     + +    R GEA +E   +  G Q 
Sbjct: 483 RRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEA-KEAASSSSGTQP 541

Query: 434 DPAVPAQQPADPSTPERQSSP-SGSEQLVRRES 465
            P  PA          R   P S +    RR S
Sbjct: 542 APPAPASPWDSKKHRSRDRKPGSHASSSARRRS 574



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 72/317 (22%), Positives = 111/317 (35%), Gaps = 42/317 (13%)

Query: 73   KPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSS 132
            K RPP   AP               SS P  + P ++G+  S++S   + ++   +  S 
Sbjct: 794  KARPPKESAP---------------SSGPPPKPPVSSGSGSSSSS--SSCSSRKVKLQSK 836

Query: 133  GYKMTTEDYKKLAPYNIRRSSTSGDTE---EEEEEEVVPFSSDEQKRRSEAASGVLRRTA 189
               +  E      P     S+  G        + E   PF   +++  +E A      T 
Sbjct: 837  VAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTK 896

Query: 190  PREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADG 249
            P++      A  K T  T+    P  +K  + V   G S  S    +L +S   S S   
Sbjct: 897  PKKTKVKAKAGAKKTKGTKGKTKP--SKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAA 954

Query: 250  GRTKASRAIW-----IECLPSMPSP--AGSQELSSRGEEIVRLQILTPRAG-LRLVAPDV 301
            G   A    W        +PS P P  A      +   + V     TP    L   A + 
Sbjct: 955  GTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEE 1014

Query: 302  EGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEG 361
             G+R     +++E     E + +   EE  + P T  A S+A  +     S        G
Sbjct: 1015 AGVRGGAEEEEEE-----EEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSA-------G 1062

Query: 362  LAAVDIGSERGSSSATS 378
              A D G+E G +S  S
Sbjct: 1063 STAGDSGAEDGPASRVS 1079



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 73/303 (24%), Positives = 111/303 (36%), Gaps = 57/303 (18%)

Query: 124  AGPPRPSSSGYKMTTEDYKKLAPYNI------RRSSTSGDTEEEEEEEVVPFSSDEQKRR 177
            A PP P+ +    T +   K    +         +   G  EEEEEEE      +E++  
Sbjct: 981  AAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEE-EEEEEEEE 1039

Query: 178  SEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPAL 237
             + A+     TA         AA  ST P+  + A       +   EDGP+ +    P L
Sbjct: 1040 QQPATTTATSTA---------AAAPSTAPSAGSTAG------DSGAEDGPASRVSQLPTL 1084

Query: 238  ARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSR--GEEIVRL--QILTPRAG 293
                P +  A    T +     +  L ++        L+SR   +E+++   QIL+ R  
Sbjct: 1085 PPPMPWNLPAGVDCTTSG----VLALTALLFKMEEANLASRAKAQELIQATNQILSHRK- 1139

Query: 294  LRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSG 353
                 P   GM  +P       P S  L     G  ++  P       S  L     G G
Sbjct: 1140 ----PPSSLGMTPAP------VPTSLGLP---PGPSSYLLP------GSLPLG----GCG 1176

Query: 354  ATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDV 413
            +T   P GLAA    S++   S++S      D+       QE A  + K A+  Y  K  
Sbjct: 1177 STPPTPTGLAAT---SDKREGSSSSEGRGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKD 1233

Query: 414  ATR 416
             T+
Sbjct: 1234 ITK 1236


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 97/434 (22%), Positives = 151/434 (34%), Gaps = 49/434 (11%)

Query: 44  KQDESE-GRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYI--IRGVFTKP------ 94
           K+D+++ G     P+ R+           P+P PP T A    +     V  KP      
Sbjct: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63

Query: 95  -IDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSS 153
            I  ++ P+   P+A  T  +  S    A+    RP +SG        K  +P  +    
Sbjct: 64  GIGGATIPESA-PRAGPTRSAGTSSRNPAS----RPPASGRGERAPPAKNTSPGPVSSPG 118

Query: 154 TSGDTEEEEE--EEVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQ 211
            +  T       ++ +  S++E   R +A        AP+  +    A + ++GPT  T 
Sbjct: 119 RASGTTRPGPLGQKGLRISAEETVARGKATE------APKRSALSAGARRDTSGPTPGTP 172

Query: 212 APFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAG 271
           +P +A+R       G       P   AR  P     +G R   S A   E   + PSPA 
Sbjct: 173 SPAMARRSRAA---GTEVGLPRPAPSARPRP---PTEGPRKSVSSA--SEHSTTEPSPAA 224

Query: 272 SQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAF 331
            +  S+ G     LQ    R+      P     RS P  +      +   Q    G +A 
Sbjct: 225 RRRPSAGG----GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL 280

Query: 332 RAPNT-----DAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADR 386
           R P       DAA +   LS   + + +  +  +  A   + +   SSS T   A P   
Sbjct: 281 RPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPL 340

Query: 387 KSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQER-----PGAPRGGQGDPAVPAQQ 441
              S +A    +  P             T +G    +      P  P      P  P Q 
Sbjct: 341 APPSPSAPPSLQTLPSPPAT--PPSQATTSLGSPTLQATHSFLPSPPLSPLATP--PPQA 396

Query: 442 PADPSTPERQSSPS 455
           P   + P  Q+ PS
Sbjct: 397 PPALALPPLQAPPS 410


>gi|217035154 RCSD domain containing 1 [Homo sapiens]
          Length = 416

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 76/343 (22%), Positives = 122/343 (35%), Gaps = 65/343 (18%)

Query: 72  PKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSS 131
           P   PPST +  G     V ++P ++   P        G+     + VRT  +   RP S
Sbjct: 117 PFHSPPSTPSSPG-----VRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPS 171

Query: 132 SGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDE--QKRRSEAASGVLRRTA 189
             ++ +  D  +L  +    SS     +EE+ +EV+P  S        SE A+G   RT 
Sbjct: 172 RRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRT- 230

Query: 190 PREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADG 249
                          GP ++        R E  EED  +E++++     RS   S   DG
Sbjct: 231 --------------LGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRS---SEEVDG 273

Query: 250 GRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPG 309
                      E +P  P  +G                  P A  R  +P  E     P 
Sbjct: 274 QHPAQ------EEVPESPQTSG------------------PEAENRCGSPREE----KPA 305

Query: 310 NKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDI-- 367
            ++ E   + E++ +    E    P  D ++ + +L +G        S P G+   D+  
Sbjct: 306 GEEAEMEKATEVKGERVQNEEV-GPEHD-SQETKKLEEGAAVKETPHSPPGGVKGGDVPK 363

Query: 368 ---GSERGSSSAT-----SVSAVPADRKSNSTAAQEDAKADPK 402
              G E+    A      S    PA  +++S    E A   P+
Sbjct: 364 QEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPE 406


>gi|150378549 tangerin [Homo sapiens]
          Length = 1523

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 66/266 (24%), Positives = 94/266 (35%), Gaps = 14/266 (5%)

Query: 170 SSDEQKRRSEAASGVLRRTAPR--EHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGP 227
           S  +   R+  A G +   APR  E S  + ++++    T  T AP + K  + +    P
Sbjct: 259 SRGQGSERANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRPPVP 318

Query: 228 SEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQI 287
             + + P A      G  SA   + +A      E   +   P  S E    G+   R ++
Sbjct: 319 QGEDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLGP--SIEDKGSGDPFGRQRL 376

Query: 288 LTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSD 347
                      P+  G+ + P +  +EA   R   R    EE+      DA + S     
Sbjct: 377 KAEEMDTE-DRPEASGVDTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHV 435

Query: 348 GNVGSGATGSRPEG-LAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALA 406
              G  ATG  PE           RGS     V     D   +  +      A   G L 
Sbjct: 436 DTKGPEATGVMPEARCRGTPEAPPRGSQGRLGVRT--RDEAPSGLSLPPAEPAGHSGQLG 493

Query: 407 DYEGKDVATRVGEAWQERPGAP-RGG 431
           D EG   A     A QER GA  RGG
Sbjct: 494 DLEGARAA-----AGQEREGAEVRGG 514


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.126    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,363,380
Number of Sequences: 37866
Number of extensions: 1833852
Number of successful extensions: 10919
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 637
Number of HSP's that attempted gapping in prelim test: 9391
Number of HSP's gapped (non-prelim): 2020
length of query: 689
length of database: 18,247,518
effective HSP length: 109
effective length of query: 580
effective length of database: 14,120,124
effective search space: 8189671920
effective search space used: 8189671920
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.