Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 148277106
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
(829 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148277106 hypothetical protein LOC442213 [Homo sapiens] 1662 0.0
gi|148271104 patched domain containing 1 [Homo sapiens] 795 0.0
gi|194018513 patched domain containing 3 [Homo sapiens] 154 2e-37
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 103 9e-22
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 101 3e-21
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 96 1e-19
gi|134254450 patched isoform S [Homo sapiens] 79 1e-14
gi|134254435 patched isoform S [Homo sapiens] 79 1e-14
gi|134254468 patched isoform S [Homo sapiens] 79 1e-14
gi|134254452 patched isoform S [Homo sapiens] 79 1e-14
gi|134254432 patched isoform L' [Homo sapiens] 79 1e-14
gi|134254466 patched isoform M [Homo sapiens] 79 1e-14
gi|134254446 patched isoform L [Homo sapiens] 79 1e-14
gi|52145305 patched 2 [Homo sapiens] 67 5e-11
gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase iso... 48 3e-05
gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isofo... 48 3e-05
gi|25952134 dispatched A [Homo sapiens] 37 0.098
gi|149274653 patched domain containing 2 [Homo sapiens] 36 0.17
gi|94967012 olfactory receptor, family 52, subfamily B, member 4... 34 0.49
gi|188497683 FAST kinase domains 1 [Homo sapiens] 31 4.1
gi|115387102 adenylate cyclase 2 [Homo sapiens] 31 5.4
gi|22749049 Leber congenital amaurosis 5-like [Homo sapiens] 31 5.4
gi|51243065 zinc finger CCHC-type and RNA binding motif 1 [Homo ... 30 7.0
gi|5032179 tripartite motif-containing 28 protein [Homo sapiens] 30 9.2
gi|209976994 adenylate cyclase 10 [Homo sapiens] 30 9.2
>gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
Length = 829
Score = 1662 bits (4305), Expect = 0.0
Identities = 829/829 (100%), Positives = 829/829 (100%)
Query: 1 MLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPS 60
MLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPS
Sbjct: 1 MLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPS 60
Query: 61 HSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSPTGDNILLQAEGILQTHRA 120
HSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSPTGDNILLQAEGILQTHRA
Sbjct: 61 HSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSPTGDNILLQAEGILQTHRA 120
Query: 121 VLEMKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENE 180
VLEMKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENE
Sbjct: 121 VLEMKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENE 180
Query: 181 FCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDC 240
FCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDC
Sbjct: 181 FCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDC 240
Query: 241 LRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWR 300
LRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWR
Sbjct: 241 LRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWR 300
Query: 301 RTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILL 360
RTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILL
Sbjct: 301 RTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILL 360
Query: 361 NYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHE 420
NYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHE
Sbjct: 361 NYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHE 420
Query: 421 TNPYQHHFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLAS 480
TNPYQHHFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLAS
Sbjct: 421 TNPYQHHFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLAS 480
Query: 481 DSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQF 540
DSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQF
Sbjct: 481 DSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQF 540
Query: 541 LKVSNVSANNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRD 600
LKVSNVSANNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRD
Sbjct: 541 LKVSNVSANNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRD 600
Query: 601 KQKEITEVLEKLRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFF 660
KQKEITEVLEKLRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFF
Sbjct: 601 KQKEITEVLEKLRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFF 660
Query: 661 LVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFV 720
LVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFV
Sbjct: 661 LVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFV 720
Query: 721 LATEHTRTQCIKSSLQDHGTAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLL 780
LATEHTRTQCIKSSLQDHGTAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLL
Sbjct: 721 LATEHTRTQCIKSSLQDHGTAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLL 780
Query: 781 HCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV 829
HCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV
Sbjct: 781 HCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV 829
>gi|148271104 patched domain containing 1 [Homo sapiens]
Length = 888
Score = 795 bits (2052), Expect = 0.0
Identities = 409/895 (45%), Positives = 581/895 (64%), Gaps = 73/895 (8%)
Query: 1 MLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPS 60
MLRQVL RGL++ RLG ++ HPVFF + P +++I G S +R+Q E +E L+AP
Sbjct: 1 MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGAS-FSRYQVEESVEHLLAPQ 59
Query: 61 HSLAKIERSLASSLFP-------------------------------LDQSKSQLYSDLH 89
HSLAKIER+L +SLFP LDQ + L LH
Sbjct: 60 HSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLH 119
Query: 90 T---------PG---RYGRVILLSPTGD-------NILLQAEGILQTHRA-------VLE 123
PG + + +L+ ++L + + T+R +
Sbjct: 120 AAVTKIQVPRPGFNYTFAHICILNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITH 179
Query: 124 MKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCK 183
+KDGR + GHQLGGV +SKD RVKSA AIQ+TYYLQ+ S D++ E+WE+ FC
Sbjct: 180 LKDGRAVYNGHQLGGVTV--HSKD-RVKSAEAIQLTYYLQSINSLN-DMVAERWESSFCD 235
Query: 184 LIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRS 243
+R Q+ + ++++Y S SL DF KTS ++ ++ SL+L++T A L SM+DC+RS
Sbjct: 236 TVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRS 295
Query: 244 KPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTK 303
KP+LGLLG++T+ ++ +TAAGI +T GKYNST LG+PF +GHG G FE+LS WR+T+
Sbjct: 296 KPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTR 355
Query: 304 ENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYF 363
E+ K+R A Y+D M+++++T+++Y +TFG+GASPFTNIEA ++FC N C++I NY
Sbjct: 356 EDQHVKERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYL 415
Query: 364 YIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD--GHQQTSHHET 421
Y+ SF+GS LVF G +E N HSIFC K+P E L KP W++ +++ E
Sbjct: 416 YVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEA 475
Query: 422 NPYQHHFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASD 481
N Y+ H + FL+ +Y +WITN YVKPFVV+ YLIY SF+ MG LQ+S+G+++ N++A+
Sbjct: 476 NTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATA 535
Query: 482 SPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFL 541
+ ++ Y QQKYFSNYSPVIGFY+YE +EYWN+SVQ+D+ GF +SW E Y +L
Sbjct: 536 TQTIEYTTAQQKYFSNYSPVIGFYIYESIEYWNTSVQEDVLEYTKGFVRISWFESYLNYL 595
Query: 542 KVSNVSAN-NKSDFISVLQSSFLKKPEFQHFRNDIIFSKA-GDESNIIASRLYLVARTSR 599
+ NVS K +F +L++SFLK P+F HF+ DIIFSK DE +++ASR++LVA+T
Sbjct: 596 RKLNVSTGLPKKNFTDMLRNSFLKAPQFSHFQEDIIFSKKYNDEVDVVASRMFLVAKTME 655
Query: 600 DKQKEITEVLEKLRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTF 659
++E+ ++LE LR LS++ ++FIVFNPSFV+MD Y+ S+ P+ + L +L +
Sbjct: 656 TNREELYDLLETLRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSA 715
Query: 660 FLVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTF 719
FLV L N W+ L+V S+E GV+G MTLW V++DCIS+LCLIY +N+ ID+CAP+L TF
Sbjct: 716 FLVADSLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTF 775
Query: 720 VLATEHTRTQCIKSSLQDHGTAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTL 779
VL + TRT+ +K++L+ HG AILQ+ +++GL+PL VPSNLT TLF+CL L T
Sbjct: 776 VLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPSNLTCTLFRCLFLIAFVTF 835
Query: 780 LHCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENP-----DHVTTV 829
HCF ILPV LTF PPSKK K+KK + REEIEC+E+ + D +TTV
Sbjct: 836 FHCFAILPVILTFLPPSKKKRKEKKNP--ENREEIECVEMVDIDSTRVVDQITTV 888
>gi|194018513 patched domain containing 3 [Homo sapiens]
Length = 767
Score = 154 bits (390), Expect = 2e-37
Identities = 148/647 (22%), Positives = 263/647 (40%), Gaps = 95/647 (14%)
Query: 17 LGLCVSRHPVFFLTVPAVLTITFGLSALNRFQP---EGDLERLVAPSHSLAKIERSLASS 73
LG V HP FL P +LT G L + P E DLE P S AK ER
Sbjct: 130 LGWQVGAHPWIFLLAPLMLTAALGTGFL--YLPKDEEEDLEEHYTPVGSPAKAERRFVQG 187
Query: 74 LFPLDQSKSQLYSDLHTPGRYGRVI-------LLSPTGDNILLQAEGILQTHRAVLEM-- 124
F + S S T + ++ LL P + + +G +Q R E
Sbjct: 188 HFTTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQDLRVAREKGS 247
Query: 125 -----------------------------------------KDGRNS------FIGHQLG 137
GR+ F G+ LG
Sbjct: 248 QIQYQQVCARYRALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGFFGGYILG 307
Query: 138 GVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCKLIRKLQE--EHQEL 195
G + + Q + A+A+++ YYL+T D+ ++W ++ +++
Sbjct: 308 GSLGM----GQLLLRAKAMRLLYYLKTE-DPEYDVQSKQWLTHLLDQFTNIKNILALKKI 362
Query: 196 QLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTV 255
++ S S +F TS+ ++ +LI+ A S DC+R+K + GV++
Sbjct: 363 EVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVISA 422
Query: 256 CISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTKENLPFKDRIADA 315
+++++ G+ + + PF +G G +F ++S W +T ++R+++
Sbjct: 423 FLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMSNV 482
Query: 316 YSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVF 375
YS V+ T+T+ + G ++ +V+ FC +++L YFY + FG+ +
Sbjct: 483 YSKAAVSITITTITNILALYTGI--MSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMAL 540
Query: 376 AGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLRE 435
G+ E + C + A+ P W S + + H I F R+
Sbjct: 541 DGKREV-----VCLCWLKKAD-----PKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRD 590
Query: 436 HYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYF 495
++ ++T K FVV +Y++Y S GC + +G ++ NL + DS Y V++ YF
Sbjct: 591 YFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYF 650
Query: 496 SNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGF---------TAVSWVEQYYQFLKVSNV 546
S+Y P + V + ++YW+ V+ L F W++ Y Q+LK ++
Sbjct: 651 SDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYLKGNSQ 710
Query: 547 SANNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYL 593
N K+ F++ + P FQH DI S + + II+SR ++
Sbjct: 711 DPNEKNTFMNNIPDFLSNFPNFQH---DINISSSNE---IISSRGFI 751
>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapiens]
Length = 1332
Score = 103 bits (256), Expect = 9e-22
Identities = 169/777 (21%), Positives = 309/777 (39%), Gaps = 130/777 (16%)
Query: 146 KDQRVKSARAIQITYYLQTYGSATQDLIGEK-WENEFCKLIRKLQEEHQEL-QLYSLASF 203
K + A A+ +T+ L Y + L K WE F + +R Q + Q+ +A
Sbjct: 560 KGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAER 619
Query: 204 SLWRDFHKTS-----ILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCIS 258
SL + ++T+ I A S +++ L + L + SS + + SK LGL GV V +
Sbjct: 620 SLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGA 679
Query: 259 IITAAGIFFITDGKYNSTLLG-IPFFAMGHGTKGVFELLSGWRR--TKENLPFKDRIADA 315
++ A G F + + +L +PF + G +F + ++R + P + I A
Sbjct: 680 VMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRA 739
Query: 316 YSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVF 375
V + + S I F +GA T + AV+ F ++++L++ S F + L
Sbjct: 740 LGRVAPSMLLCSLSEAICFFLGA--LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSL 797
Query: 376 AGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLRE 435
+ ++ + CC P Q + G + + F ++
Sbjct: 798 DSKRQEASRLDVCCCVKP------------QELPPPGQGE-----------GLLLGFFQK 834
Query: 436 HYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYF 495
Y ++ + + V++L+L S IS G + L DS + Y + +YF
Sbjct: 835 AYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYF 894
Query: 496 SNYSPVIGFYVYEPLEYWNSSVQDDLRRLCS-------GFT------------------A 530
+PV Y L Y N S + + +CS FT A
Sbjct: 895 EVGAPV---YFVTTLGY-NFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPA 950
Query: 531 VSWVEQYYQFLKVSN-----VSANNKSDFI--SVLQSSFLKK------------------ 565
SWV+ + +L S+ +S NK F +V + LK
Sbjct: 951 SSWVDDFIDWLTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHK 1010
Query: 566 --PEFQHFRNDIIFSKAG-----------DESNIIASRLYLVARTSRDKQKEITEVLEKL 612
P F + R +I K G + ++ASR + ++ Q + TE L
Sbjct: 1011 YLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLKNSQ-DYTEALRAA 1069
Query: 613 RPL--SLSKSIRFIV-FNPSF---------VFMDHYSLSVTVPVLIAG-FGVLLVLILTF 659
R L +++ +R + +P+F VF + Y + +L G F + L L+ TF
Sbjct: 1070 RELAANITADLRKVPGTDPAFEVFPYTITNVFYEQY-----LTILPEGLFMLSLCLVPTF 1124
Query: 660 FLVIHPLG-----NFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAP 714
+ LG +LS+ I + +G M LW + + +S++ L+ + +++ +
Sbjct: 1125 AVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSH 1184
Query: 715 LLFTFVLATEHTRTQCIKSSLQDHGTAILQNVT-SFLIGLVPLLFVPSNL-TFTLFKCLL 772
+ +F ++T+ T + K + G+A+ V + L G++ L + L F+ L
Sbjct: 1185 ITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNL 1244
Query: 773 LTGGCTLLHCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV 829
L LLH V LPV L++ P + +++ E + + + P+H + V
Sbjct: 1245 LITLLGLLHGLVFLPVILSYVGPDV--NPALALEQKRAEEAVAAVMVASCPNHPSRV 1299
>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
Length = 1278
Score = 101 bits (251), Expect = 3e-21
Identities = 141/756 (18%), Positives = 307/756 (40%), Gaps = 120/756 (15%)
Query: 147 DQRVKSARAIQITYYLQTYGSATQDLI-GEKWENEFCKLIRKLQEEHQELQLYSLASFSL 205
DQ +A A+ IT+ + Y + T+ L + WE EF ++ + + L + A S+
Sbjct: 552 DQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPN--LTISFTAERSI 609
Query: 206 WRDFHKTSILARSKVLVSLVLILTTATLS-SSMKDCLR----SKPFLGLLGVLTVCISII 260
+ ++ S V++S ++ +L+ +K C R SK LG+ G+L V S+
Sbjct: 610 EDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVA 669
Query: 261 TAAGIFFITDGKYNSTLLG-IPFFAMGHGTKGVFELLSGWRRTK--ENLPFKDRIADAYS 317
+ G+F ++ IPF + G +F L+ ++R + + ++
Sbjct: 670 CSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLG 729
Query: 318 DVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVFAG 377
+V + ++S + F +GA + + AV F +++ +++ + F S L
Sbjct: 730 EVAPSMFLSSFSETVAFFLGA--LSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDI 787
Query: 378 QLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLREHY 437
+ ++ IFCC + AE DG + + F + Y
Sbjct: 788 KRQEKNRLDIFCC-VRGAE--------------DGTSVQASESC-------LFRFFKNSY 825
Query: 438 NEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYFSN 497
+ + +++P V+ +++ SFS ++ G + + DS V Y +Y +
Sbjct: 826 SPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL-H 884
Query: 498 YSPVIGFYVYEPLEY------------------------WNSSVQDDLRRLCSGFTAVSW 533
P + F + E +Y +N++ D+ R+ GF SW
Sbjct: 885 AGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRI--GFAPSSW 942
Query: 534 VEQYYQFLK--VSNVSANNKSDFI---SVLQSSFLK----KPEFQH-------------F 571
++ Y+ ++K S +N +D SV+ + ++ PE + F
Sbjct: 943 IDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMF 1002
Query: 572 RNDIIFSKAGDESNI---------------IASRLYLVARTSRDKQKEITEVLEKLRPLS 616
+D K G + + + ++ T + + L+K R ++
Sbjct: 1003 LSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIA 1062
Query: 617 LS---------KSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLG 667
+ + R ++ +VF + Y + + G + + ++T L+ L
Sbjct: 1063 SNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELW 1122
Query: 668 NFWLI-LSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHT 726
+ ++ ++ + + + G+M LW + ++ +S++ L+ + +++ C+ + F ++ + +
Sbjct: 1123 SAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGS 1182
Query: 727 RTQCIKSSLQDHGTAILQNVT-SFLIGLVPLLFVPSNL----TFTLFKCLLLTGGCTLLH 781
R + + +L G+++ +T + G+V L F S + F ++ ++L G H
Sbjct: 1183 RVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGA---TH 1239
Query: 782 CFVILPVFLTFFPPSKKHHKK---KKRAKRKEREEI 814
+ LPV L++ PS K ++R K ERE +
Sbjct: 1240 GLIFLPVLLSYIGPSVNKAKSCATEERYKGTERERL 1275
>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapiens]
Length = 1359
Score = 95.9 bits (237), Expect = 1e-19
Identities = 173/803 (21%), Positives = 310/803 (38%), Gaps = 155/803 (19%)
Query: 146 KDQRVKSARAIQITYYLQTYGSATQDLIGEK-WENEFCKLIRKLQEEHQEL-QLYSLASF 203
K + A A+ +T+ L Y + L K WE F + +R Q + Q+ +A
Sbjct: 560 KGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAER 619
Query: 204 SLWRDFHKTS-----ILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCIS 258
SL + ++T+ I A S +++ L + L + SS + + SK LGL GV V +
Sbjct: 620 SLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGA 679
Query: 259 IITAAGIFFITDGKYNSTLLG-IPFFAMGHGTKGVFELLSGWRR--TKENLPFKDRIADA 315
++ A G F + + +L +PF + G +F + ++R + P + I A
Sbjct: 680 VMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRA 739
Query: 316 YSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVF 375
V + + S I F +GA T + AV+ F ++++L++ S F + L
Sbjct: 740 LGRVAPSMLLCSLSEAICFFLGA--LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSL 797
Query: 376 AGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLRE 435
+ ++ + CC P Q + G + + F ++
Sbjct: 798 DSKRQEASRLDVCCCVKP------------QELPPPGQGE-----------GLLLGFFQK 834
Query: 436 HYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYF 495
Y ++ + + V++L+L S IS G + L DS + Y + +YF
Sbjct: 835 AYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYF 894
Query: 496 SNYSPVIGFYVYEPLEYWNSSVQDDLRRLCS-------GFT------------------A 530
+PV Y L Y N S + + +CS FT A
Sbjct: 895 EVGAPV---YFVTTLGY-NFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPA 950
Query: 531 VSWVEQYYQFLKVSN-----VSANNKSDF--------------ISVLQSSFLKKPEFQH- 570
SWV+ + +L S+ +S NK F +S+ S E H
Sbjct: 951 SSWVDDFIDWLTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHK 1010
Query: 571 ----FRND------------------------------IIFSKAGDESNIIAS--RLYLV 594
F ND I S + S I++ LYL+
Sbjct: 1011 YLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLL 1070
Query: 595 ARTSR--------DKQKEITEVLEKLRPL--SLSKSIRFIV-FNPSF---------VFMD 634
TSR ++ TE L R L +++ +R + +P+F VF +
Sbjct: 1071 DSTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYE 1130
Query: 635 HYSLSVTVPVLIAG-FGVLLVLILTFFLVIHPLG-----NFWLILSVTSIELGVLGLMTL 688
Y + +L G F + L L+ TF + LG +LS+ I + +G M L
Sbjct: 1131 QY-----LTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMAL 1185
Query: 689 WNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQNVT- 747
W + + +S++ L+ + +++ + + +F ++T+ T + K + G+A+ V
Sbjct: 1186 WGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAM 1245
Query: 748 SFLIGLVPLLFVPSNL-TFTLFKCLLLTGGCTLLHCFVILPVFLTFFPPSKKHHKKKKRA 806
+ L G++ L + L F+ LL LLH V LPV L++ P +
Sbjct: 1246 TNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDV--NPALALE 1303
Query: 807 KRKEREEIECIEIQENPDHVTTV 829
+++ E + + + P+H + V
Sbjct: 1304 QKRAEEAVAAVMVASCPNHPSRV 1326
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 79.3 bits (194), Expect = 1e-14
Identities = 62/260 (23%), Positives = 112/260 (43%), Gaps = 7/260 (2%)
Query: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234
E W+ + +++ + ++ ++ S + +L S ++ +V +L+L A L+
Sbjct: 246 EAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT 305
Query: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293
DC +S+ +GL GVL V +S+ G+ + +N +T +PF A+G G VF
Sbjct: 306 MLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF 365
Query: 294 ELLSGWRRTKEN--LPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFC 351
L + T +N +PF+DR + + +TS F M A I A++ F
Sbjct: 366 LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFS 423
Query: 352 QNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD 411
V ++ N+ + F + L ++R IFCC ++ + R +D
Sbjct: 424 LQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF--TSPCVSRVIQVEPQAYTD 481
Query: 412 GHQQTSHHETNPYQHHFIQH 431
H T + PY H H
Sbjct: 482 THDNTRYSPPPPYSSHSFAH 501
Score = 43.5 bits (101), Expect = 8e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 9/183 (4%)
Query: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488
+ F +HY ++ K V+ L+L S G ++ DG ++ +++ ++ +
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 489 MVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSA 548
Q KYFS Y+ I V + +Y N +Q L L F+ V +V + ++ +
Sbjct: 641 AAQFKYFSFYNMYI---VTQKADYPN--IQHLLYDLHRSFSNVKYV-MLEENKQLPKMWL 694
Query: 549 NNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEV 608
+ D++ LQ +F E + K G + ++A +L LV SRDK +I+++
Sbjct: 695 HYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKL-LVQTGSRDKPIDISQL 751
Query: 609 LEK 611
++
Sbjct: 752 TKQ 754
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/174 (22%), Positives = 78/174 (44%), Gaps = 12/174 (6%)
Query: 625 VFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLG 684
+F ++ + H+ L VL F V V +L + G ++L++ ++EL G
Sbjct: 865 LFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTA----GIIVMVLALMTVEL--FG 918
Query: 685 LMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQ 744
+M L + + + ++ LI ++ ++ + F+ A + + + L+ +L
Sbjct: 919 MMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLA-LEHMFAPVLD 977
Query: 745 NVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795
S L+G+ L+ S F + F L + +L+ V+LPV L+FF P
Sbjct: 978 GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 79.3 bits (194), Expect = 1e-14
Identities = 62/260 (23%), Positives = 112/260 (43%), Gaps = 7/260 (2%)
Query: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234
E W+ + +++ + ++ ++ S + +L S ++ +V +L+L A L+
Sbjct: 246 EAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT 305
Query: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293
DC +S+ +GL GVL V +S+ G+ + +N +T +PF A+G G VF
Sbjct: 306 MLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF 365
Query: 294 ELLSGWRRTKEN--LPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFC 351
L + T +N +PF+DR + + +TS F M A I A++ F
Sbjct: 366 LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFS 423
Query: 352 QNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD 411
V ++ N+ + F + L ++R IFCC ++ + R +D
Sbjct: 424 LQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF--TSPCVSRVIQVEPQAYTD 481
Query: 412 GHQQTSHHETNPYQHHFIQH 431
H T + PY H H
Sbjct: 482 THDNTRYSPPPPYSSHSFAH 501
Score = 43.5 bits (101), Expect = 8e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 9/183 (4%)
Query: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488
+ F +HY ++ K V+ L+L S G ++ DG ++ +++ ++ +
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 489 MVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSA 548
Q KYFS Y+ I V + +Y N +Q L L F+ V +V + ++ +
Sbjct: 641 AAQFKYFSFYNMYI---VTQKADYPN--IQHLLYDLHRSFSNVKYV-MLEENKQLPKMWL 694
Query: 549 NNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEV 608
+ D++ LQ +F E + K G + ++A +L LV SRDK +I+++
Sbjct: 695 HYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKL-LVQTGSRDKPIDISQL 751
Query: 609 LEK 611
++
Sbjct: 752 TKQ 754
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/174 (22%), Positives = 78/174 (44%), Gaps = 12/174 (6%)
Query: 625 VFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLG 684
+F ++ + H+ L VL F V V +L + G ++L++ ++EL G
Sbjct: 865 LFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTA----GIIVMVLALMTVEL--FG 918
Query: 685 LMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQ 744
+M L + + + ++ LI ++ ++ + F+ A + + + L+ +L
Sbjct: 919 MMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLA-LEHMFAPVLD 977
Query: 745 NVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795
S L+G+ L+ S F + F L + +L+ V+LPV L+FF P
Sbjct: 978 GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 79.3 bits (194), Expect = 1e-14
Identities = 62/260 (23%), Positives = 112/260 (43%), Gaps = 7/260 (2%)
Query: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234
E W+ + +++ + ++ ++ S + +L S ++ +V +L+L A L+
Sbjct: 246 EAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT 305
Query: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293
DC +S+ +GL GVL V +S+ G+ + +N +T +PF A+G G VF
Sbjct: 306 MLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF 365
Query: 294 ELLSGWRRTKEN--LPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFC 351
L + T +N +PF+DR + + +TS F M A I A++ F
Sbjct: 366 LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFS 423
Query: 352 QNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD 411
V ++ N+ + F + L ++R IFCC ++ + R +D
Sbjct: 424 LQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF--TSPCVSRVIQVEPQAYTD 481
Query: 412 GHQQTSHHETNPYQHHFIQH 431
H T + PY H H
Sbjct: 482 THDNTRYSPPPPYSSHSFAH 501
Score = 43.5 bits (101), Expect = 8e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 9/183 (4%)
Query: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488
+ F +HY ++ K V+ L+L S G ++ DG ++ +++ ++ +
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 489 MVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSA 548
Q KYFS Y+ I V + +Y N +Q L L F+ V +V + ++ +
Sbjct: 641 AAQFKYFSFYNMYI---VTQKADYPN--IQHLLYDLHRSFSNVKYV-MLEENKQLPKMWL 694
Query: 549 NNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEV 608
+ D++ LQ +F E + K G + ++A +L LV SRDK +I+++
Sbjct: 695 HYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKL-LVQTGSRDKPIDISQL 751
Query: 609 LEK 611
++
Sbjct: 752 TKQ 754
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/174 (22%), Positives = 78/174 (44%), Gaps = 12/174 (6%)
Query: 625 VFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLG 684
+F ++ + H+ L VL F V V +L + G ++L++ ++EL G
Sbjct: 865 LFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTA----GIIVMVLALMTVEL--FG 918
Query: 685 LMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQ 744
+M L + + + ++ LI ++ ++ + F+ A + + + L+ +L
Sbjct: 919 MMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLA-LEHMFAPVLD 977
Query: 745 NVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795
S L+G+ L+ S F + F L + +L+ V+LPV L+FF P
Sbjct: 978 GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254452 patched isoform S [Homo sapiens]
Length = 1296
Score = 79.3 bits (194), Expect = 1e-14
Identities = 62/260 (23%), Positives = 112/260 (43%), Gaps = 7/260 (2%)
Query: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234
E W+ + +++ + ++ ++ S + +L S ++ +V +L+L A L+
Sbjct: 246 EAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT 305
Query: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293
DC +S+ +GL GVL V +S+ G+ + +N +T +PF A+G G VF
Sbjct: 306 MLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF 365
Query: 294 ELLSGWRRTKEN--LPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFC 351
L + T +N +PF+DR + + +TS F M A I A++ F
Sbjct: 366 LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFS 423
Query: 352 QNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD 411
V ++ N+ + F + L ++R IFCC ++ + R +D
Sbjct: 424 LQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF--TSPCVSRVIQVEPQAYTD 481
Query: 412 GHQQTSHHETNPYQHHFIQH 431
H T + PY H H
Sbjct: 482 THDNTRYSPPPPYSSHSFAH 501
Score = 43.5 bits (101), Expect = 8e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 9/183 (4%)
Query: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488
+ F +HY ++ K V+ L+L S G ++ DG ++ +++ ++ +
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 489 MVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSA 548
Q KYFS Y+ I V + +Y N +Q L L F+ V +V + ++ +
Sbjct: 641 AAQFKYFSFYNMYI---VTQKADYPN--IQHLLYDLHRSFSNVKYV-MLEENKQLPKMWL 694
Query: 549 NNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEV 608
+ D++ LQ +F E + K G + ++A +L LV SRDK +I+++
Sbjct: 695 HYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKL-LVQTGSRDKPIDISQL 751
Query: 609 LEK 611
++
Sbjct: 752 TKQ 754
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/174 (22%), Positives = 78/174 (44%), Gaps = 12/174 (6%)
Query: 625 VFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLG 684
+F ++ + H+ L VL F V V +L + G ++L++ ++EL G
Sbjct: 865 LFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTA----GIIVMVLALMTVEL--FG 918
Query: 685 LMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQ 744
+M L + + + ++ LI ++ ++ + F+ A + + + L+ +L
Sbjct: 919 MMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLA-LEHMFAPVLD 977
Query: 745 NVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795
S L+G+ L+ S F + F L + +L+ V+LPV L+FF P
Sbjct: 978 GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254432 patched isoform L' [Homo sapiens]
Length = 1446
Score = 79.3 bits (194), Expect = 1e-14
Identities = 62/260 (23%), Positives = 112/260 (43%), Gaps = 7/260 (2%)
Query: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234
E W+ + +++ + ++ ++ S + +L S ++ +V +L+L A L+
Sbjct: 396 EAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT 455
Query: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293
DC +S+ +GL GVL V +S+ G+ + +N +T +PF A+G G VF
Sbjct: 456 MLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF 515
Query: 294 ELLSGWRRTKEN--LPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFC 351
L + T +N +PF+DR + + +TS F M A I A++ F
Sbjct: 516 LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFS 573
Query: 352 QNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD 411
V ++ N+ + F + L ++R IFCC ++ + R +D
Sbjct: 574 LQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF--TSPCVSRVIQVEPQAYTD 631
Query: 412 GHQQTSHHETNPYQHHFIQH 431
H T + PY H H
Sbjct: 632 THDNTRYSPPPPYSSHSFAH 651
Score = 43.5 bits (101), Expect = 8e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 9/183 (4%)
Query: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488
+ F +HY ++ K V+ L+L S G ++ DG ++ +++ ++ +
Sbjct: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790
Query: 489 MVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSA 548
Q KYFS Y+ I V + +Y N +Q L L F+ V +V + ++ +
Sbjct: 791 AAQFKYFSFYNMYI---VTQKADYPN--IQHLLYDLHRSFSNVKYV-MLEENKQLPKMWL 844
Query: 549 NNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEV 608
+ D++ LQ +F E + K G + ++A +L LV SRDK +I+++
Sbjct: 845 HYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKL-LVQTGSRDKPIDISQL 901
Query: 609 LEK 611
++
Sbjct: 902 TKQ 904
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/174 (22%), Positives = 78/174 (44%), Gaps = 12/174 (6%)
Query: 625 VFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLG 684
+F ++ + H+ L VL F V V +L + G ++L++ ++EL G
Sbjct: 1015 LFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTA----GIIVMVLALMTVEL--FG 1068
Query: 685 LMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQ 744
+M L + + + ++ LI ++ ++ + F+ A + + + L+ +L
Sbjct: 1069 MMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLA-LEHMFAPVLD 1127
Query: 745 NVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795
S L+G+ L+ S F + F L + +L+ V+LPV L+FF P
Sbjct: 1128 GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1179
>gi|134254466 patched isoform M [Homo sapiens]
Length = 1381
Score = 79.3 bits (194), Expect = 1e-14
Identities = 62/260 (23%), Positives = 112/260 (43%), Gaps = 7/260 (2%)
Query: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234
E W+ + +++ + ++ ++ S + +L S ++ +V +L+L A L+
Sbjct: 331 EAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT 390
Query: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293
DC +S+ +GL GVL V +S+ G+ + +N +T +PF A+G G VF
Sbjct: 391 MLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF 450
Query: 294 ELLSGWRRTKEN--LPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFC 351
L + T +N +PF+DR + + +TS F M A I A++ F
Sbjct: 451 LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFS 508
Query: 352 QNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD 411
V ++ N+ + F + L ++R IFCC ++ + R +D
Sbjct: 509 LQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF--TSPCVSRVIQVEPQAYTD 566
Query: 412 GHQQTSHHETNPYQHHFIQH 431
H T + PY H H
Sbjct: 567 THDNTRYSPPPPYSSHSFAH 586
Score = 43.5 bits (101), Expect = 8e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 9/183 (4%)
Query: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488
+ F +HY ++ K V+ L+L S G ++ DG ++ +++ ++ +
Sbjct: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
Query: 489 MVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSA 548
Q KYFS Y+ I V + +Y N +Q L L F+ V +V + ++ +
Sbjct: 726 AAQFKYFSFYNMYI---VTQKADYPN--IQHLLYDLHRSFSNVKYV-MLEENKQLPKMWL 779
Query: 549 NNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEV 608
+ D++ LQ +F E + K G + ++A +L LV SRDK +I+++
Sbjct: 780 HYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKL-LVQTGSRDKPIDISQL 836
Query: 609 LEK 611
++
Sbjct: 837 TKQ 839
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/174 (22%), Positives = 78/174 (44%), Gaps = 12/174 (6%)
Query: 625 VFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLG 684
+F ++ + H+ L VL F V V +L + G ++L++ ++EL G
Sbjct: 950 LFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTA----GIIVMVLALMTVEL--FG 1003
Query: 685 LMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQ 744
+M L + + + ++ LI ++ ++ + F+ A + + + L+ +L
Sbjct: 1004 MMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLA-LEHMFAPVLD 1062
Query: 745 NVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795
S L+G+ L+ S F + F L + +L+ V+LPV L+FF P
Sbjct: 1063 GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1114
>gi|134254446 patched isoform L [Homo sapiens]
Length = 1447
Score = 79.3 bits (194), Expect = 1e-14
Identities = 62/260 (23%), Positives = 112/260 (43%), Gaps = 7/260 (2%)
Query: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234
E W+ + +++ + ++ ++ S + +L S ++ +V +L+L A L+
Sbjct: 397 EAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT 456
Query: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293
DC +S+ +GL GVL V +S+ G+ + +N +T +PF A+G G VF
Sbjct: 457 MLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF 516
Query: 294 ELLSGWRRTKEN--LPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFC 351
L + T +N +PF+DR + + +TS F M A I A++ F
Sbjct: 517 LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFS 574
Query: 352 QNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD 411
V ++ N+ + F + L ++R IFCC ++ + R +D
Sbjct: 575 LQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF--TSPCVSRVIQVEPQAYTD 632
Query: 412 GHQQTSHHETNPYQHHFIQH 431
H T + PY H H
Sbjct: 633 THDNTRYSPPPPYSSHSFAH 652
Score = 43.5 bits (101), Expect = 8e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 9/183 (4%)
Query: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488
+ F +HY ++ K V+ L+L S G ++ DG ++ +++ ++ +
Sbjct: 732 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 791
Query: 489 MVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSA 548
Q KYFS Y+ I V + +Y N +Q L L F+ V +V + ++ +
Sbjct: 792 AAQFKYFSFYNMYI---VTQKADYPN--IQHLLYDLHRSFSNVKYV-MLEENKQLPKMWL 845
Query: 549 NNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEV 608
+ D++ LQ +F E + K G + ++A +L LV SRDK +I+++
Sbjct: 846 HYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKL-LVQTGSRDKPIDISQL 902
Query: 609 LEK 611
++
Sbjct: 903 TKQ 905
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/174 (22%), Positives = 78/174 (44%), Gaps = 12/174 (6%)
Query: 625 VFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLG 684
+F ++ + H+ L VL F V V +L + G ++L++ ++EL G
Sbjct: 1016 LFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTA----GIIVMVLALMTVEL--FG 1069
Query: 685 LMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQ 744
+M L + + + ++ LI ++ ++ + F+ A + + + L+ +L
Sbjct: 1070 MMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLA-LEHMFAPVLD 1128
Query: 745 NVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795
S L+G+ L+ S F + F L + +L+ V+LPV L+FF P
Sbjct: 1129 GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1180
>gi|52145305 patched 2 [Homo sapiens]
Length = 1203
Score = 67.4 bits (163), Expect = 5e-11
Identities = 50/221 (22%), Positives = 99/221 (44%), Gaps = 11/221 (4%)
Query: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234
+ W+ F +L ++ E+ Q+++ +S +L H S ++ ++V+ +L+L A ++
Sbjct: 353 QAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVT 412
Query: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293
DC +S+ +GL GVL V +++ + G+ + +N +T +PF A+G G VF
Sbjct: 413 MLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVF 472
Query: 294 ELLSGWRRTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQN 353
L + P ++R+ + + +TS F M A I A++ F
Sbjct: 473 LLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAA--LVPIPALRAFSLQ 530
Query: 354 MCVSILLNYFYIFSFFGSCLVFAGQLEQNRYH----SIFCC 390
+ + + + F + L L+ R H + CC
Sbjct: 531 AAIVVGCTFVAVMLVFPAIL----SLDLRRRHCQRLDVLCC 567
Score = 43.5 bits (101), Expect = 8e-04
Identities = 44/175 (25%), Positives = 80/175 (45%), Gaps = 18/175 (10%)
Query: 630 FVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFW------LILSVTSIELGVL 683
F+F + Y L + L+A V ++L+ TF + L N W L+L++ ++EL
Sbjct: 951 FLFWEQY-LGLRRCFLLA---VCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVEL--F 1004
Query: 684 GLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAIL 743
G+M + + I ++ L+ ++ ++ + F L T+ +R +L+ +
Sbjct: 1005 GIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAPVT 1063
Query: 744 QNVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795
S L+GL L+ S+ F + F L + LLH V+LPV L+ P
Sbjct: 1064 DGAISTLLGL--LMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGP 1116
Score = 32.3 bits (72), Expect = 1.9
Identities = 15/70 (21%), Positives = 31/70 (44%)
Query: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488
+ HF R + + + K V++L+ S G + DG + +++ + ++
Sbjct: 668 LAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFL 727
Query: 489 MVQQKYFSNY 498
Q +YFS Y
Sbjct: 728 SAQLRYFSLY 737
>gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
isoform 2 [Homo sapiens]
Length = 835
Score = 48.1 bits (113), Expect = 3e-05
Identities = 34/164 (20%), Positives = 68/164 (41%), Gaps = 16/164 (9%)
Query: 241 LRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWR 300
L SK LG+ G+ T+ S + + + D + +PFF + L
Sbjct: 86 LGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFAL 145
Query: 301 RTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILL 360
+ ++ IA + + T+T+ + + + G+G + + +++ C C+S+L
Sbjct: 146 SSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGT--MSGVRQLEIMCCFGCMSVLA 203
Query: 361 NYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVW 404
NYF +FF +C+ +L S E + +P+W
Sbjct: 204 NYFVFMTFFPACVSLVLEL--------------SRESREGRPIW 233
>gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform
1 [Homo sapiens]
Length = 888
Score = 48.1 bits (113), Expect = 3e-05
Identities = 34/164 (20%), Positives = 68/164 (41%), Gaps = 16/164 (9%)
Query: 241 LRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWR 300
L SK LG+ G+ T+ S + + + D + +PFF + L
Sbjct: 86 LGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFAL 145
Query: 301 RTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILL 360
+ ++ IA + + T+T+ + + + G+G + + +++ C C+S+L
Sbjct: 146 SSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGT--MSGVRQLEIMCCFGCMSVLA 203
Query: 361 NYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVW 404
NYF +FF +C+ +L S E + +P+W
Sbjct: 204 NYFVFMTFFPACVSLVLEL--------------SRESREGRPIW 233
>gi|25952134 dispatched A [Homo sapiens]
Length = 1524
Score = 36.6 bits (83), Expect = 0.098
Identities = 33/126 (26%), Positives = 53/126 (42%), Gaps = 14/126 (11%)
Query: 285 MGHGTKGVFELLSGWRRTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPF--- 341
+G G F L W TK + P A+ V +T + F+T A+ F
Sbjct: 567 VGIGADDAFVLCDVWNYTKFDKPH----AETSETVSITLQHAALSMFVTSFTTAAAFYAN 622
Query: 342 --TNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCC-KIPSAEYL 398
+NI A++ F +IL+NY + ++ + +V L + +IF C K P +
Sbjct: 623 YVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVV----LHERYLLNIFTCFKKPQQQIY 678
Query: 399 DRKPVW 404
D K W
Sbjct: 679 DNKSCW 684
>gi|149274653 patched domain containing 2 [Homo sapiens]
Length = 1392
Score = 35.8 bits (81), Expect = 0.17
Identities = 37/177 (20%), Positives = 72/177 (40%), Gaps = 13/177 (7%)
Query: 631 VFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLGLMTLWN 690
+FM+ + + L+ + + + F H L ++LS+ I V+ +M
Sbjct: 1173 IFMEIVGVQSALCGLVLSLLICVAAVAVF--TTHILLLLPVLLSILGIVCLVVTIMYWSG 1230
Query: 691 VDMDCISILCLIYTLNFAIDHCAPLLFTFVLA--------TEHTRTQ---CIKSSLQDHG 739
+M + + L + ++D+C L+ ++LA E RTQ +++ G
Sbjct: 1231 WEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVG 1290
Query: 740 TAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPPS 796
AI+ + + +I VPL F K + L G ++L+ + L PS
Sbjct: 1291 VAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPS 1347
>gi|94967012 olfactory receptor, family 52, subfamily B, member 4
[Homo sapiens]
Length = 314
Score = 34.3 bits (77), Expect = 0.49
Identities = 36/142 (25%), Positives = 60/142 (42%), Gaps = 34/142 (23%)
Query: 646 IAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVL----GLMTLW----NVDMD-CI 696
+ G +L+ +ILT + P+ F +L+ I L L W ++ +D CI
Sbjct: 41 LLGNSLLIFIILTKRSLHEPMYLFLCMLAGADIVLSTCTIPQALAIFWFRAGDISLDRCI 100
Query: 697 SILCLIYT---------LNFAIDH----CAPLLFTFVLATEHTRTQCIKSSLQDHGTAIL 743
+ L I++ L A DH C PL +T +L + C+ SL+ +GT
Sbjct: 101 TQLFFIHSTFISESGILLVMAFDHYIAICYPLRYTTILTNALIKKICVTVSLRSYGT--- 157
Query: 744 QNVTSFLIGLVPLLFVPSNLTF 765
+ P++F+ LTF
Sbjct: 158 ---------IFPIIFLLKRLTF 170
>gi|188497683 FAST kinase domains 1 [Homo sapiens]
Length = 847
Score = 31.2 bits (69), Expect = 4.1
Identities = 27/92 (29%), Positives = 41/92 (44%), Gaps = 2/92 (2%)
Query: 569 QHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEVLEKLRPLSLSKSIR-FIVFN 627
QHF +DI + G+ ++ I+S YL + +EK+ P ++ IR F V N
Sbjct: 525 QHFMDDINYINVGEIASFISSTDYLSTLLLDRIASVAVQQIEKIHPFTIPAIIRPFSVLN 584
Query: 628 PSFVFMDHYSLSVTVPVLIAGFGVLLVLILTF 659
D + L V L + G+L IL F
Sbjct: 585 YDPPQRDEF-LGTCVQHLNSYLGILDPFILVF 615
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 30.8 bits (68), Expect = 5.4
Identities = 28/129 (21%), Positives = 57/129 (44%), Gaps = 11/129 (8%)
Query: 634 DHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVL-----GLMTL 688
DH + +TVP +A F + +L+ + L F L++ + + +G L G ++
Sbjct: 74 DHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSP 133
Query: 689 WNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGT-----AIL 743
W+ + I+ ++YT+ + ++ + + ++ HT + S G IL
Sbjct: 134 WDQVSFFLFIIFVVYTM-LPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQIL 192
Query: 744 QNVTSFLIG 752
NV F+ G
Sbjct: 193 ANVIIFICG 201
>gi|22749049 Leber congenital amaurosis 5-like [Homo sapiens]
Length = 670
Score = 30.8 bits (68), Expect = 5.4
Identities = 25/117 (21%), Positives = 56/117 (47%), Gaps = 9/117 (7%)
Query: 105 DNILLQAEGILQTHRAVLEMKD-GRNSFIGHQLGGVVEVPNSKDQRVKS--------ARA 155
D+ LL+ + ILQ + + E K+ + H+L + ++ D++++S RA
Sbjct: 232 DSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRA 291
Query: 156 IQITYYLQTYGSATQDLIGEKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKT 212
++T + + + E L +KL+E+ +EL++ ++ S + ++ H T
Sbjct: 292 FSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDT 348
>gi|51243065 zinc finger CCHC-type and RNA binding motif 1 [Homo
sapiens]
Length = 217
Score = 30.4 bits (67), Expect = 7.0
Identities = 17/31 (54%), Positives = 21/31 (67%), Gaps = 3/31 (9%)
Query: 794 PPSKKHHKKKKRAKRKEREEIECIEIQENPD 824
PP KK KKKK+A E EEIE E++E+ D
Sbjct: 130 PPKKKEKKKKKKAPEPE-EEIE--EVEESED 157
>gi|5032179 tripartite motif-containing 28 protein [Homo sapiens]
Length = 835
Score = 30.0 bits (66), Expect = 9.2
Identities = 13/41 (31%), Positives = 22/41 (53%)
Query: 157 QITYYLQTYGSATQDLIGEKWENEFCKLIRKLQEEHQELQL 197
+ ++L + A QD+ GE+W C ++ L+EE L L
Sbjct: 644 EFCFHLDCHLPALQDVPGEEWSCSLCHVLPDLKEEDGSLSL 684
>gi|209976994 adenylate cyclase 10 [Homo sapiens]
Length = 1610
Score = 30.0 bits (66), Expect = 9.2
Identities = 16/42 (38%), Positives = 22/42 (52%), Gaps = 3/42 (7%)
Query: 348 KVFCQNMCVSILLNYFYIFSFFGSCLVFAGQLEQNR---YHS 386
K F +C+ ILL +++ F CL F Q E NR +HS
Sbjct: 1375 KAFFYFVCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHS 1416
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.139 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,417,470
Number of Sequences: 37866
Number of extensions: 1249076
Number of successful extensions: 4975
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 4888
Number of HSP's gapped (non-prelim): 60
length of query: 829
length of database: 18,247,518
effective HSP length: 111
effective length of query: 718
effective length of database: 14,044,392
effective search space: 10083873456
effective search space used: 10083873456
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.