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Search of human proteins with 148233596
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148233596 LPS-responsive vesicle trafficking, beach and
anchor containing [Homo sapiens]
(2863 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148233596 LPS-responsive vesicle trafficking, beach and ancho... 5694 0.0
gi|62422577 neurobeachin [Homo sapiens] 3588 0.0
gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens] 491 e-138
gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens] 491 e-138
gi|149944548 neurobeachin-like 2 [Homo sapiens] 455 e-127
gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens] 455 e-127
gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho... 365 e-100
gi|191252801 WDFY family member 4 [Homo sapiens] 341 5e-93
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ... 312 3e-84
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc... 312 3e-84
gi|54292123 lysosomal trafficking regulator [Homo sapiens] 267 1e-70
gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens] 105 6e-22
gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens] 105 6e-22
gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens] 105 6e-22
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 59 9e-08
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 50 2e-05
gi|192807336 arsenate resistance protein 2 isoform e [Homo sapiens] 50 4e-05
gi|192807332 arsenate resistance protein 2 isoform c [Homo sapiens] 50 4e-05
gi|32189425 WD repeat domain 69 [Homo sapiens] 50 4e-05
gi|192807334 arsenate resistance protein 2 isoform d [Homo sapiens] 49 7e-05
gi|58331218 arsenate resistance protein 2 isoform a [Homo sapiens] 49 7e-05
gi|16445033 ACRC protein [Homo sapiens] 48 1e-04
gi|38261962 activating transcription factor 7 interacting protei... 47 3e-04
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 47 4e-04
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 46 5e-04
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 46 5e-04
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 46 5e-04
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 46 5e-04
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 46 6e-04
gi|56243583 WD repeat domain 18 [Homo sapiens] 44 0.002
>gi|148233596 LPS-responsive vesicle trafficking, beach and anchor
containing [Homo sapiens]
Length = 2863
Score = 5694 bits (14770), Expect = 0.0
Identities = 2863/2863 (100%), Positives = 2863/2863 (100%)
Query: 1 MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEV 60
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEV
Sbjct: 1 MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEV 60
Query: 61 SNRDIVETVFNLLVGGQFDLEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAILKK 120
SNRDIVETVFNLLVGGQFDLEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAILKK
Sbjct: 61 SNRDIVETVFNLLVGGQFDLEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAILKK 120
Query: 121 SIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK 180
SIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
Sbjct: 121 SIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK 180
Query: 181 GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMD 240
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMD
Sbjct: 181 GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMD 240
Query: 241 PVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKFDFKPQKWY 300
PVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKFDFKPQKWY
Sbjct: 241 PVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKFDFKPQKWY 300
Query: 301 MVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ 360
MVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
Sbjct: 301 MVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ 360
Query: 361 MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFT 420
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFT
Sbjct: 361 MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFT 420
Query: 421 YNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFPLF 480
YNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFPLF
Sbjct: 421 YNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFPLF 480
Query: 481 AQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV 540
AQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
Sbjct: 481 AQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV 540
Query: 541 SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIG 600
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIG
Sbjct: 541 SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIG 600
Query: 601 TVNIYNTIRRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLM 660
TVNIYNTIRRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLM
Sbjct: 601 TVNIYNTIRRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLM 660
Query: 661 FIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG 720
FIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
Sbjct: 661 FIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG 720
Query: 721 LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLIT 780
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLIT
Sbjct: 721 LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLIT 780
Query: 781 MTTYNVLFEILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRR 840
MTTYNVLFEILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRR
Sbjct: 781 MTTYNVLFEILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRR 840
Query: 841 AFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH 900
AFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
Sbjct: 841 AFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH 900
Query: 901 AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASG 960
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASG
Sbjct: 901 AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASG 960
Query: 961 IRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMK 1020
IRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMK
Sbjct: 961 IRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMK 1020
Query: 1021 AEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA 1080
AEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
Sbjct: 1021 AEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA 1080
Query: 1081 SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASE 1140
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASE
Sbjct: 1081 SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASE 1140
Query: 1141 AGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIA 1200
AGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIA
Sbjct: 1141 AGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIA 1200
Query: 1201 VESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA 1260
VESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
Sbjct: 1201 VESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA 1260
Query: 1261 SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLT 1320
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLT
Sbjct: 1261 SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLT 1320
Query: 1321 DLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLS 1380
DLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLS
Sbjct: 1321 DLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLS 1380
Query: 1381 AATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL 1440
AATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
Sbjct: 1381 AATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL 1440
Query: 1441 RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPV 1500
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPV
Sbjct: 1441 RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPV 1500
Query: 1501 RDLDRLLQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHS 1560
RDLDRLLQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHS
Sbjct: 1501 RDLDRLLQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHS 1560
Query: 1561 QSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE 1620
QSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
Sbjct: 1561 QSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE 1620
Query: 1621 VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKD 1680
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKD
Sbjct: 1621 VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKD 1680
Query: 1681 ILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTF 1740
ILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTF
Sbjct: 1681 ILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTF 1740
Query: 1741 NTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERL 1800
NTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERL
Sbjct: 1741 NTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERL 1800
Query: 1801 EHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQ 1860
EHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQ
Sbjct: 1801 EHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQ 1860
Query: 1861 EWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESL 1920
EWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESL
Sbjct: 1861 EWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESL 1920
Query: 1921 CAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFW 1980
CAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFW
Sbjct: 1921 CAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFW 1980
Query: 1981 RLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSI 2040
RLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSI
Sbjct: 1981 RLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSI 2040
Query: 2041 RSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVT 2100
RSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVT
Sbjct: 2041 RSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVT 2100
Query: 2101 SSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANR 2160
SSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANR
Sbjct: 2101 SSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANR 2160
Query: 2161 VAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREI 2220
VAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREI
Sbjct: 2161 VAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREI 2220
Query: 2221 SNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKR 2280
SNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKR
Sbjct: 2221 SNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKR 2280
Query: 2281 AAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTF 2340
AAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTF
Sbjct: 2281 AAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTF 2340
Query: 2341 SSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTS 2400
SSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTS
Sbjct: 2341 SSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTS 2400
Query: 2401 EEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITD 2460
EEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITD
Sbjct: 2401 EEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITD 2460
Query: 2461 PVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPV 2520
PVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPV
Sbjct: 2461 PVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPV 2520
Query: 2521 THVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTG 2580
THVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTG
Sbjct: 2521 THVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTG 2580
Query: 2581 MHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDV 2640
MHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDV
Sbjct: 2581 MHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDV 2640
Query: 2641 VTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEV 2700
VTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEV
Sbjct: 2641 VTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEV 2700
Query: 2701 TCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYEN 2760
TCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYEN
Sbjct: 2701 TCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYEN 2760
Query: 2761 GLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGC 2820
GLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGC
Sbjct: 2761 GLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGC 2820
Query: 2821 DAGIRAMALSYDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY 2863
DAGIRAMALSYDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY
Sbjct: 2821 DAGIRAMALSYDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY 2863
>gi|62422577 neurobeachin [Homo sapiens]
Length = 2946
Score = 3588 bits (9303), Expect = 0.0
Identities = 1870/2980 (62%), Positives = 2234/2980 (74%), Gaps = 200/2980 (6%)
Query: 15 GDDGGGGGREETPTEGGALSL-----KPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETV 69
G G G G + G++ L P +PIR IRMKFAVL GL++VGEVSNRDIVETV
Sbjct: 36 GTGGSGMGELRGASGSGSVMLPAGMINPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETV 95
Query: 70 FNLLVGGQFDLEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCT 129
NLLVGG+FDLEMNFIIQ+ ESI CM +LLE CD+TCQAE+WSMFTAIL+KS+RNLQ T
Sbjct: 96 LNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTST 155
Query: 130 EVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDKGRWPPHAGK 189
EVGL+E+VL K+ VD+MIADLLVDMLGVLASY++TV+ELKL FS L+G+ G WP HA K
Sbjct: 156 EVGLIEQVLLKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVK 215
Query: 190 LLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDK 249
LLSVL MPQ++GPD FFNFPG SAAAIALPPIAKWPYQNGFT +TW RMDP+NNINVDK
Sbjct: 216 LLSVLNQMPQRHGPDTFFNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDK 275
Query: 250 DKPYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYN 309
DKPYLYCFRTSKG+GYSAHFVG CLIVTS+KSKGKGFQHCVK+DF+P+KWYM++IVHIYN
Sbjct: 276 DKPYLYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYN 335
Query: 310 RWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQMTAVYLFSE 369
RW+NSE+RCYVNG+L SYG++ W VNT+D++DKCFLGSSETADANRVFCGQ+ AVY+FSE
Sbjct: 336 RWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSE 395
Query: 370 ALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQ 429
ALN AQIFAI+QLG GYK TFKFK+ESD+ LAEHHK +LYDGKL+S+IAFTYN +ATDAQ
Sbjct: 396 ALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQ 455
Query: 430 LCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYL 489
LCLESSPK+N SIFVHSPHALMLQDVKA++THSI SA+HSIGG+QVLFPLFAQLD RQ
Sbjct: 456 LCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLN 515
Query: 490 SDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCL 549
+++ T+C+TLLAF++ELLK+S+AMQEQML KGFLVIGY LEKSS+ H++RAVLE L
Sbjct: 516 DSQVETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFL 575
Query: 550 AFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIR 609
+F+KYL L +G PLLKQLCDH+L NPAIWIHTPAKVQL LYTYLS EFIGT IY TIR
Sbjct: 576 SFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIR 635
Query: 610 RVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKD 669
RVGTVL +MHTLKYYYW +NP D SGITPKGLDGPRP+QKE++SLRAF+L+F+KQL++KD
Sbjct: 636 RVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKD 695
Query: 670 SGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNGLRVIYKLLA 729
GVKEDELQ+ILNYLLTMHED+N+ DVLQLLVALMSEHP SMIPAFDQRNG+RVIYKLLA
Sbjct: 696 RGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLA 755
Query: 730 SKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFE 789
SKSE I VQALK +GYFLKHL KRK E+M H LF+LL ERLML TN +T+TTYN L+E
Sbjct: 756 SKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYE 815
Query: 790 ILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKL 849
IL EQ+ TQV+HK HP+PDS+VKIQNP ILKV+ATLL+NS E MEVRR FLSDMIKL
Sbjct: 816 ILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKL 875
Query: 850 FNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGW 909
F+NSRENRR LLQCSVWQ+WM SL Y NPKNS+EQKITEMVY IFRILLYHA+KYEWGGW
Sbjct: 876 FSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGW 935
Query: 910 RVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIR------- 962
RVWVDTLSI HSKVT+E HKE LA ++ E Q + +E I +V SG+
Sbjct: 936 RVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAK 995
Query: 963 -----RDINVSVGSQQPDTK-DSPVCPH----FTTNGNENSSIEKTSSLESASNIELQTT 1012
R+I SQ P+++ D PV + + + + S ++E+
Sbjct: 996 GGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVSDDILGNSDRPGSGVHVEVHDL 1055
Query: 1013 NTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSF-ITTGKD 1071
+ K E +L D ETL A ++E ++ N + K
Sbjct: 1056 LVDIKAEKVEATEVKLDDMDLSPETLVGGENGA--------LVEVESLLDNVYSAAVEKL 1107
Query: 1072 SMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQD 1131
V I E+D + D+ +E+ + + P +E L EL
Sbjct: 1108 QNNVHGSVGIIKKNEEKDNGPLITLADE---KEDLPNSSTSFLFDKIPKQEEKLLPELSS 1164
Query: 1132 NSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMS 1191
N + P + L + +DD + + + + K+ I T T+ G S++S
Sbjct: 1165 NHIIPNIQDTQVHLGV--SDDLGLLAHMTGSVDLTCTSSIIEEKEFKIHT-TSDGMSSIS 1221
Query: 1192 PETTVSQIAVESDLGQMLE--EGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNV 1249
E DL + E + T T ET E+SS + + +D ++
Sbjct: 1222 ----------ERDLASSTKGLEYAEMTATTLET-----------ESSSSKIVPNIDAGSI 1260
Query: 1250 ATDTERLELKASPNVEAPQPHRHVLEISRQHEQPGQGIAPD--------------AVNGQ 1295
+DTER + E+ + R + + G+ I Q
Sbjct: 1261 ISDTER----SDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQ 1316
Query: 1296 RRD----SRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNV 1351
RR R+T+FRIPEF WS MHQRLLTDLLF++ETD+ +WRSHSTK+VMDFVNS++N+
Sbjct: 1317 RRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENI 1376
Query: 1352 IFVHNTIHLISQVMDNMVMACGGILPLLSAATSAT---HELENIEPTQGLSIEASVTFLQ 1408
IFVHNTIHLISQ++DN+++ACGGILPLLSAATS T ELENIE TQG+S E +VTFL
Sbjct: 1377 IFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLS 1436
Query: 1409 RLISLVDVLIFASSLGFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRG 1468
RL+++VDVL+FASSL F+EIEAEK+MSSGG++RQCLRLVC VAVRNCLEC+Q + RG
Sbjct: 1437 RLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQ--RDRG 1494
Query: 1469 DK----ALKPMHSLIP---LGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFR 1521
+K + KP +P +A+K+P++ V G +SP++D DRLLQD+DINRLRAVVFR
Sbjct: 1495 NKSSHGSSKPQE--VPQSVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFR 1552
Query: 1522 DIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSE-NENV------- 1573
D++DSKQAQFLALAVVYFISVLMVSKYRDILEPQ E T TGS+ N+
Sbjct: 1553 DVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRE-----TTRTGSQPGRNIRQEINSP 1607
Query: 1574 -------------------------------SLSEITPAAFSTL-----TTASVEESEST 1597
S + TPAAF T E+ +
Sbjct: 1608 TSTVVVIPSIPHPSLNHGFLAKLIPEQSFGHSFYKETPAAFPDTIKEKETPTPGEDIQVE 1667
Query: 1598 SSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKND 1657
SS DSGIGEE + + E+ S GPDA+SE+LSTLS EV KS E+ +
Sbjct: 1668 SSIPHTDSGIGEEQVASILNGAELE-------TSTGPDAMSELLSTLSSEVKKSQESLTE 1720
Query: 1658 RGNDLDTKAT--PSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQ 1715
++ AT S+S +K +NVK+IL+SLV P + P +P +
Sbjct: 1721 NPSETLKPATSISSISQTKGINVKEILKSLVAAPVEIAECGPEPIPYPDPALKRETQAIL 1780
Query: 1716 PVQFRSFDRSVIVAAKK--------SAVSPSTFNTSIPTNAVSVV---------SSVDSA 1758
P+QF SFDRSV+V KK + V +T + +PT + S + S +++
Sbjct: 1781 PMQFHSFDRSVVVPVKKPPPGSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTT 1840
Query: 1759 QASDMGGESPGSRSS------NAKLPSVPTVDSVSQDPVSNMSITERLEHALEKAAPLLR 1812
A D G S S SS + LP+V TV + +D NMSIT +LE ALEK APLLR
Sbjct: 1841 GAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLR 1900
Query: 1813 EIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGL 1872
EIFVDFAPFLSRTLLGSHGQELLIEG LVCMKSS+SVVELVMLLCSQEWQNSIQKNAGL
Sbjct: 1901 EIFVDFAPFLSRTLLGSHGQELLIEG--LVCMKSSTSVVELVMLLCSQEWQNSIQKNAGL 1958
Query: 1873 AFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDE 1932
AFIEL+NEGRLL MKDH+VRVANEAEFIL+RQRAED+H+HAEFES CAQY+AD+RE+E
Sbjct: 1959 AFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEE 2018
Query: 1933 KMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDLRRR 1992
KMCDHLI AAK+RDHVTA QL QKI+NILT+KHGAWG + S+ +FWRLDYWEDDLRRR
Sbjct: 2019 KMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRR 2078
Query: 1993 RRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQALGNQNSEN 2052
RRFVRN GSTH EA LK A+E+ T+ED++ K K++ RSQA+ NQN+E
Sbjct: 2079 RRFVRNAFGSTHAEALLKAAIEY-----------GTEEDVV-KSKKTFRSQAIVNQNAET 2126
Query: 2053 EILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEED 2112
E++LEGDDD +S + EK+++NLAGPV LSTPAQL+AP VV KGTLS+T++E+YFEVDE+D
Sbjct: 2127 ELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDD 2186
Query: 2113 PNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPAT 2172
FKKID K+LAYTEGLHGKW+F+EIR++FSRRYLLQNTALE+FMANR +VMFNFPD AT
Sbjct: 2187 SAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQAT 2246
Query: 2173 VKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTI 2232
VKKVV LPRVGVGTS+GLPQ RRISLA+PRQL+K+SNMTQRWQ REISNFEYLMFLNTI
Sbjct: 2247 VKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTI 2306
Query: 2233 AGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWE 2292
AGR+YNDLNQYPVFPWV+TNYESEELDLTLP NFRDLSKPIGALNPKRA F+AERYE+WE
Sbjct: 2307 AGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWE 2366
Query: 2293 DDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQR 2352
DDQ P +HY THYSTA+ L+WL+RIEPFTT+FLN GKFDH DRTFSS++R+WR SQR
Sbjct: 2367 DDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRTSQR 2426
Query: 2353 DTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALE 2412
DTSD+KELIPEFYYLPEMFVN N YNLGV +D VV+DV+LPPWAK E+FV INR+ALE
Sbjct: 2427 DTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALE 2486
Query: 2413 SEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIR 2472
SEFVSCQLHQWIDLIFGYKQ+GPEAVRALNVF+YLTYEG+VNL+SITDPVLREA+EAQI+
Sbjct: 2487 SEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQ 2546
Query: 2473 SFGQTPSQLLIEPHPPRGSAMQV-----SPLMFTDKAQQDVIMVLKFPSNSPVTHVAANT 2527
+FGQTPSQLLIEPHPPR SAM + SPLMF D+ QQDVIMVLKFPSNSPVTHVAANT
Sbjct: 2547 NFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANT 2606
Query: 2528 QPGLATPAVITVTANRLFAVNKWHNLPAHQGA---VQDQPYQLPVEIDPLIASNTGMHRR 2584
P L PAV+TVT +RLFAVN+WHN +GA DQ + LP+E+DPLIA+N+G+++R
Sbjct: 2607 LPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKR 2666
Query: 2585 QITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCL 2644
QITDL+DQSIQ+++ CFV+T+DNRYIL+CGFWDKSFRVYST+TG+L Q+VFGHWDVVTCL
Sbjct: 2667 QITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCL 2726
Query: 2645 ARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNP-GSETAAPRAILTGHDYEVTCA 2703
ARSESYIGG+CYI+SGSRDATLLLWYW+G+ IGDNP S+ APRA+LTGHD+EV C
Sbjct: 2727 ARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCV 2786
Query: 2704 AVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLF 2763
+VCAELGLV+SG++EGPCL+H++ GDLLR LEGPENCL P+LI S EGHC+I+YE G F
Sbjct: 2787 SVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRF 2846
Query: 2764 CTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAG 2823
FS+NGKL A ME +D+ RAI LS DGQ L+TGGD GVV V Q D KQL+ YPGCDAG
Sbjct: 2847 SNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAG 2906
Query: 2824 IRAMALSYDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY 2863
IRAM LS+DQR +I+GMASGSIV F DFNRWH+E+Q RY
Sbjct: 2907 IRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY 2946
>gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens]
Length = 2694
Score = 491 bits (1263), Expect = e-138
Identities = 368/1111 (33%), Positives = 562/1111 (50%), Gaps = 130/1111 (11%)
Query: 1796 ITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGT---SLVCMKSSSSVVE 1852
I +LEH L ++ EI+ P L RTL+ S ELL SL SSS E
Sbjct: 1614 ILGKLEHVLSQSIKEQTEIYSFLIP-LVRTLV-SKIYELLFMNLHLPSLPFTNGSSSFFE 1671
Query: 1853 LVMLLC-SQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVA------NEAEFILSR 1905
C S EWQ I+K + +++ + T D +A EA +
Sbjct: 1672 DFQEYCNSNEWQVYIEKYI-VPYMKQYE-----AHTFYDGHENMALYWKDCYEALMVNMH 1725
Query: 1906 QR-AEDIHRHAEFESLCAQ-YSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINI-LT 1962
+R E +F+ L + ++ R++ +++++ + T + K I + LT
Sbjct: 1726 KRDREGGESKLKFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRW--KAIQLYLT 1783
Query: 1963 DKHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLR 2022
+ G W P+ W+L E+ R R + V N TH EA+ LR
Sbjct: 1784 CERGPWAKRK-QNPIH-WKLANVENYSRMRLKLVPNYNFKTHEEASA-----------LR 1830
Query: 2023 EN-----SKATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGP 2077
+N S+ + + +L + + ++ + + L E D +VDEK+ ++
Sbjct: 1831 DNLGIQHSQPSSDTLLLEVVKQVKVSDMVEDKLD---LPEEDITARVNVDEKEEQDQKEK 1887
Query: 2078 VSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTE 2137
+ L +L+ V+ G L +T+ +YF D + +K D G KW ++
Sbjct: 1888 LVLMEDCELITIIDVIPGRLEITTQHIYFY----DGSIEKEDGV------GFDFKWPHSQ 1937
Query: 2138 IRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRI 2197
IR I RRY L+ +ALEIF ++ NF K L + +G
Sbjct: 1938 IREIHLRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKIYSRLLSLHSPNSYYGS------ 1991
Query: 2198 SLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEE 2257
SP++LFKAS +TQ+W +REISNF+YL+ +NT+AGR+YNDL QYPVFPW++ +Y SEE
Sbjct: 1992 --RSPQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEE 2049
Query: 2258 LDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQ--VPKFHYGTHYSTASFVLAWL 2315
LDL P FRDLSKPIG +N K A E+YE++ED + KFHYGTHYS ++ V+ +L
Sbjct: 2050 LDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYL 2109
Query: 2316 LRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFN 2375
+R+EPFTT + LQ G+FD ADR F SI W+ + D+KELIPEF+Y PE N N
Sbjct: 2110 IRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFPEFLENQN 2169
Query: 2376 NYNLGVMD-DGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQG 2434
+NLG + +V+DV LP WAK++E+F++ +R ALESE+VS LH+WIDLIFGYKQ+G
Sbjct: 2170 QFNLGRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRG 2229
Query: 2435 PEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSA-- 2492
P AV ALNVFYY +YEGAV+L+++TD R+A+E I +FGQTP QLL EPHPPR SA
Sbjct: 2230 PAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEE 2289
Query: 2493 -------MQVSPL----------MFTDKAQQDVIMVLK--FPSNSPVTHVAANTQPGLAT 2533
+ S L F + D I +LK P N + ++ + P L
Sbjct: 2290 AVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQYRSFMSQGS-PEL-- 2346
Query: 2534 PAVITVTANRLFAVNKW----HNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDL 2589
+IT++ N + + W N+ + ++DQ P +R I
Sbjct: 2347 --LITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPKT------------QRSINGS 2392
Query: 2590 LDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSES 2649
+++ S+ FV++ D + + G+WD S +V S G++I + H D+VTCLA
Sbjct: 2393 FAPGLEITSKLFVVSHDAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLA--TD 2450
Query: 2650 YIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAEL 2709
Y G +++SGSRD T ++W + + G P + P IL GH EV + EL
Sbjct: 2451 YCG--IHLISGSRDTTCMIW----QITQQGGVPVGLASKPFQILYGHTNEVLSVGISTEL 2504
Query: 2710 GLVLSGSQEGPCLIHSM-NGDLLRTLEGP-ENCLKPKL--IQASREGHCVIF-------- 2757
+ +SGS++G +IH++ G +RTL P E+ L + + S EGH V++
Sbjct: 2505 DMAVSGSRDGTVIIHTIQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVYSSTEEKTT 2564
Query: 2758 -YENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFA 2816
+ FS+NGK + + + I + G++++TG +G + +R + L
Sbjct: 2565 LKDKNALHLFSINGKYLGSQILKEQVSDICII--GEHIVTGSIQGFLSIRDLHSLNLSIN 2622
Query: 2817 YPGCDAGIRAMALSYDQRCIISGMASGSIVL 2847
I + ++ + I+ G+ G +++
Sbjct: 2623 PLAMRLPIHCVCVTKEYSHILVGLEDGKLIV 2653
Score = 73.6 bits (179), Expect = 3e-12
Identities = 110/551 (19%), Positives = 221/551 (40%), Gaps = 100/551 (18%)
Query: 359 GQMTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIA 418
GQ+ +V +F E L Q+ A+Y G +K + ESD+ L I
Sbjct: 783 GQLGSVIIFYEPLQPPQVKALYLAGPNCLSPWKCQ-ESDM------------ADLPGNIL 829
Query: 419 FTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFP 478
Y +A +CL+ S + H + + V+ I+ ++ IGG+ VLFP
Sbjct: 830 LYYTAKACKNSICLDLS--------TNCLHGRLTGN--KVVNWDIKDIINCIGGLNVLFP 879
Query: 479 LFAQLDY-------------------------------RQYLSDEIDLTICSTLLAFIME 507
L Q+ + + ++ + +T + +
Sbjct: 880 LLEQISHFSEGQIPEEKNESTVPESVTPVEGDWLVWTSTKASESRLERNLVATFILIVKH 939
Query: 508 LLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNGMPLLKQ 567
++ Q ++ G +G L+K + + VL + +S L+ M LL+Q
Sbjct: 940 FIQRHPINQGNLIHSHGVATLGALLQKVPSTLMDVNVLMAVQLLIEQVS-LEKNMQLLQQ 998
Query: 568 LCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWA 627
+ ++L + IW ++ YLST + ++ R+ V ++ TL+ YY
Sbjct: 999 MYQYLLFDFRIWNRGDFPFRIGHIQYLSTIIKDSRRVF---RKKYGVQFLLDTLRIYY-- 1053
Query: 628 VNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTM 687
G + ++ ++R L IK + K G +E+Q+I+ Y+
Sbjct: 1054 ----------GNGCKYNELSLDDIRTIRTSLYGLIKYFLCK--GGSHEEIQSIMGYIAAT 1101
Query: 688 HEDDNLMDVLQLLVALMSEHPNS---MIPAFDQRNGLRVIYKLLASK--SEGIRVQALKA 742
+E++ L +L +L +L+ P + F+ N ++Y LL ++ S+ +R K
Sbjct: 1102 NEEEQLFGILDVLFSLLRTSPTRGQLFLLLFEPGNA-DILYALLLNQKYSDRLREIIFKI 1160
Query: 743 MGYFLK--HLAPKRKAEVML---GHGLFSLLAERLMLQTNLITMTTYNVL-------FEI 790
M LK ++ + K + L G+ LL ++ T+LI T+ ++ F+
Sbjct: 1161 MEQMLKCTNVYERSKQHIRLREVGYSGLGLLLNEALVNTSLIKNLTHQIINTDPVINFKD 1220
Query: 791 LIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLF 850
L+ + + H+ H +V++ I + + +L+ P + + + +++LF
Sbjct: 1221 LLSVV--YISHRAH----INVRV---AICRKVLQILQFQPDAAHQISQQVGWQDTLVRLF 1271
Query: 851 NNSR-ENRRSL 860
++ EN +L
Sbjct: 1272 LKAKFENGNTL 1282
Score = 57.4 bits (137), Expect = 2e-07
Identities = 58/262 (22%), Positives = 108/262 (41%), Gaps = 15/262 (5%)
Query: 99 LEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGL-VEKVLGKIEKVDNMIADLLVDMLG 157
L+ D+ W + + R V +G+ + + L + A+ L+ + G
Sbjct: 457 LQSHDLQIFISDWLKRICCINRQSRTTCVNANMGIRIIETLDLHSSLHQTCAENLIAIHG 516
Query: 158 VLASYNLTVRELKLFFSKLQGDKGRWP-PHAGKLLSVLKHMPQKYGPDA---FFNFPGKS 213
L S +++ E++ L+ D+ P+ + + M +K ++ +FN S
Sbjct: 517 SLGSQSVSSEEIRRLLRLLRVDESESVHPYVTPVTRAILTMARKLSLESALQYFNL-SHS 575
Query: 214 AAAIALPPIAKWPYQNGFTFHTWLRMD----PVNNINVDKDKPYLYCFRTSKGLGYSAHF 269
A I++PPI KWP + F+F W +D + N + LY F T G+G+ A
Sbjct: 576 MAGISVPPIQKWP-GSAFSFSAWFCLDQDQLTLGIANKGGKRKQLYSFFTGSGMGFEAFI 634
Query: 270 V-GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNR--WKNSELRCYVNGELAS 326
G L+V + F W+ +T+VH+ + + S + Y NG+
Sbjct: 635 THSGMLVVAVCTKREYATVMLPDHSFCDSLWHNITVVHMPGKRPFGQSFVYIYDNGQQKV 694
Query: 327 YGEITWFVNTSDTFDKCFLGSS 348
+ F ++ F C +GS+
Sbjct: 695 SAPLR-FPAMNEPFTSCCIGSA 715
>gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens]
Length = 1404
Score = 491 bits (1263), Expect = e-138
Identities = 368/1111 (33%), Positives = 562/1111 (50%), Gaps = 130/1111 (11%)
Query: 1796 ITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGT---SLVCMKSSSSVVE 1852
I +LEH L ++ EI+ P L RTL+ S ELL SL SSS E
Sbjct: 324 ILGKLEHVLSQSIKEQTEIYSFLIP-LVRTLV-SKIYELLFMNLHLPSLPFTNGSSSFFE 381
Query: 1853 LVMLLC-SQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVA------NEAEFILSR 1905
C S EWQ I+K + +++ + T D +A EA +
Sbjct: 382 DFQEYCNSNEWQVYIEKYI-VPYMKQYE-----AHTFYDGHENMALYWKDCYEALMVNMH 435
Query: 1906 QR-AEDIHRHAEFESLCAQ-YSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINI-LT 1962
+R E +F+ L + ++ R++ +++++ + T + K I + LT
Sbjct: 436 KRDREGGESKLKFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRW--KAIQLYLT 493
Query: 1963 DKHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLR 2022
+ G W P+ W+L E+ R R + V N TH EA+ LR
Sbjct: 494 CERGPWAKRK-QNPIH-WKLANVENYSRMRLKLVPNYNFKTHEEASA-----------LR 540
Query: 2023 EN-----SKATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGP 2077
+N S+ + + +L + + ++ + + L E D +VDEK+ ++
Sbjct: 541 DNLGIQHSQPSSDTLLLEVVKQVKVSDMVEDKLD---LPEEDITARVNVDEKEEQDQKEK 597
Query: 2078 VSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTE 2137
+ L +L+ V+ G L +T+ +YF D + +K D G KW ++
Sbjct: 598 LVLMEDCELITIIDVIPGRLEITTQHIYFY----DGSIEKEDGV------GFDFKWPHSQ 647
Query: 2138 IRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRI 2197
IR I RRY L+ +ALEIF ++ NF K L + +G
Sbjct: 648 IREIHLRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKIYSRLLSLHSPNSYYGS------ 701
Query: 2198 SLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEE 2257
SP++LFKAS +TQ+W +REISNF+YL+ +NT+AGR+YNDL QYPVFPW++ +Y SEE
Sbjct: 702 --RSPQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEE 759
Query: 2258 LDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQ--VPKFHYGTHYSTASFVLAWL 2315
LDL P FRDLSKPIG +N K A E+YE++ED + KFHYGTHYS ++ V+ +L
Sbjct: 760 LDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYL 819
Query: 2316 LRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFN 2375
+R+EPFTT + LQ G+FD ADR F SI W+ + D+KELIPEF+Y PE N N
Sbjct: 820 IRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFPEFLENQN 879
Query: 2376 NYNLGVMD-DGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQG 2434
+NLG + +V+DV LP WAK++E+F++ +R ALESE+VS LH+WIDLIFGYKQ+G
Sbjct: 880 QFNLGRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRG 939
Query: 2435 PEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSA-- 2492
P AV ALNVFYY +YEGAV+L+++TD R+A+E I +FGQTP QLL EPHPPR SA
Sbjct: 940 PAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEE 999
Query: 2493 -------MQVSPL----------MFTDKAQQDVIMVLK--FPSNSPVTHVAANTQPGLAT 2533
+ S L F + D I +LK P N + ++ + P L
Sbjct: 1000 AVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQYRSFMSQGS-PEL-- 1056
Query: 2534 PAVITVTANRLFAVNKW----HNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDL 2589
+IT++ N + + W N+ + ++DQ P +R I
Sbjct: 1057 --LITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPKT------------QRSINGS 1102
Query: 2590 LDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSES 2649
+++ S+ FV++ D + + G+WD S +V S G++I + H D+VTCLA
Sbjct: 1103 FAPGLEITSKLFVVSHDAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLA--TD 1160
Query: 2650 YIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAEL 2709
Y G +++SGSRD T ++W + + G P + P IL GH EV + EL
Sbjct: 1161 YCG--IHLISGSRDTTCMIW----QITQQGGVPVGLASKPFQILYGHTNEVLSVGISTEL 1214
Query: 2710 GLVLSGSQEGPCLIHSM-NGDLLRTLEGP-ENCLKPKL--IQASREGHCVIF-------- 2757
+ +SGS++G +IH++ G +RTL P E+ L + + S EGH V++
Sbjct: 1215 DMAVSGSRDGTVIIHTIQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVYSSTEEKTT 1274
Query: 2758 -YENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFA 2816
+ FS+NGK + + + I + G++++TG +G + +R + L
Sbjct: 1275 LKDKNALHLFSINGKYLGSQILKEQVSDICII--GEHIVTGSIQGFLSIRDLHSLNLSIN 1332
Query: 2817 YPGCDAGIRAMALSYDQRCIISGMASGSIVL 2847
I + ++ + I+ G+ G +++
Sbjct: 1333 PLAMRLPIHCVCVTKEYSHILVGLEDGKLIV 1363
>gi|149944548 neurobeachin-like 2 [Homo sapiens]
Length = 2754
Score = 455 bits (1171), Expect = e-127
Identities = 318/949 (33%), Positives = 481/949 (50%), Gaps = 117/949 (12%)
Query: 1966 GAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEAT-LKTAVEHVCIFKLREN 2024
GAW + P+ W+L E R R + V N H EA+ L+ + V + E
Sbjct: 1815 GAW--ALRDTPIPRWKLSSAETYSRMRLKLVPNHHFDPHLEASALRDNLGEVPLTPTEEA 1872
Query: 2025 S---KATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLS 2081
S T E ++ + ++ LG E+E+ + + ++ +L+ + LS
Sbjct: 1873 SLPLAVTKEAKVSTPPELLQEDQLG----EDELA-----ELETPMEAAELDEQREKLVLS 1923
Query: 2082 TPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWL--FTEIR 2139
QLV VV G L VT+ +YF D + ++++ + EG+ + ++R
Sbjct: 1924 AECQLVTVVAVVPGLLEVTTQNVYFY----DGSTERVETE-----EGIGYDFRRPLAQLR 1974
Query: 2140 SIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVN--YLPRVGVGTSFGLPQTRR- 2196
+ RR+ L+ +ALE+F ++ NFP V + PR G Q R
Sbjct: 1975 EVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQ 2034
Query: 2197 ---------------ISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLN 2241
+S SP+++ +AS +TQ+W REISNFEYLM LNTIAGR+YNDL+
Sbjct: 2035 VYSWLLRLRPPSQGYLSSRSPQEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLS 2094
Query: 2242 QYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQ--VPKF 2299
QYPVFPWV+ +Y S LDL+ P FRDLSKPIG +NPK A E+YES+ED + KF
Sbjct: 2095 QYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKF 2154
Query: 2300 HYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKE 2359
HYGTHYS A+ V+ +L+R+EPFT+ + LQ G+FD +DR F S++ AW+ +D+KE
Sbjct: 2155 HYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKE 2214
Query: 2360 LIPEFYYLPEMFVNFNNYNLGVMD-DGTVVSDVELPPWAKTSEEFVHINRLALESEFVSC 2418
LIPEF+Y P+ N N ++LG + V DV LPPWA + E+F+ +R ALESE+VS
Sbjct: 2215 LIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSA 2274
Query: 2419 QLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTP 2478
LH+WIDLIFGYKQ+GP A ALNVFYY TYEGAV+L+ +TD R+A+E I +FGQTP
Sbjct: 2275 HLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTP 2334
Query: 2479 SQLLIEPHPPRGSAMQVS--------------------PLMFTDKAQQDVIMVLKF-PSN 2517
QLL EPHP R SA + + F + V +VL P
Sbjct: 2335 CQLLKEPHPTRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHR 2394
Query: 2518 SPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIAS 2577
P + + + P L ++TV+A+ L + W LP + DP + S
Sbjct: 2395 QPHSFITQGS-PDL----LVTVSASGLLGTHSW--LPYDRNISN----YFSFSKDPTMGS 2443
Query: 2578 NTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGH 2637
+ +R ++ V Q + D + + G WD S RV + G+L+ + H
Sbjct: 2444 H--KTQRLLSGPWVPGSGVSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCH 2501
Query: 2638 WDVVTCLARSESYIGGNCYILSGSRDATLLLW---YWNGKCSGIGDNPGSETAAPRAILT 2694
DVVTCLA I Y++SGSRD T ++W + G G+ P +L
Sbjct: 2502 LDVVTCLALDTCGI----YLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQ-------VLY 2550
Query: 2695 GHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMN----------------GDLLRTLEGPE 2738
GH V+C A+ EL + +SGS++G +IH++ G + G E
Sbjct: 2551 GHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPLGATFPGPIFHLALGSE 2610
Query: 2739 NCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGG 2798
+ + R G V + + +SVNGKL+A++ + A+ ++ D ++L G
Sbjct: 2611 GQIVVQSSAWERPGAQVTYSLH----LYSVNGKLRASLPLAEQPTALTVTED--FVLLGT 2664
Query: 2799 DRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISGMASGSIVL 2847
+ + + Q++ L IR++A++ ++ ++ G+ G +++
Sbjct: 2665 AQCALHILQLNTLLPAAPPLPMKVAIRSVAVTKERSHVLVGLEDGKLIV 2713
Score = 87.8 bits (216), Expect = 1e-16
Identities = 154/693 (22%), Positives = 249/693 (35%), Gaps = 157/693 (22%)
Query: 128 CTEVGLVEKVLGKIEK---VDNMIADLLVDMLGVLASYNLTVRELKLFF-------SKLQ 177
C + GLV +L + ++ + L+ +L L ++ EL+ S+
Sbjct: 489 CVQAGLVGCLLETLSTGLALEARCQEQLLALLQALGRVSIRPMELRHLLRPRPGLDSEPG 548
Query: 178 GDKGRWPPHAGKLLSVLKHMPQKYGPDAFFNFPG--KSAAAIALPPIAKWPYQNGFTFHT 235
G + HAG ++ L M + GP + S A I +PP+ +WP GFTFH
Sbjct: 549 GAEAGKARHAGAVIRTLSGMARHQGPARALRYFDLTPSMAGIMVPPVQRWPGP-GFTFHA 607
Query: 236 WLRMDPVNNINVDK-----DKPYLYCFRTSKGLGYSAHFVG-GCLIVTSIKSKGKGFQHC 289
WL + P++ + LY F TS G G+ A F G L+V K
Sbjct: 608 WLCLHPMDTAPTPAPTRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRKEYLTMSL 667
Query: 290 VKFDFKPQKWYMVTI-------------VHIYNRW---KNSELRCYVNGE------LASY 327
+ F W+ V I VH+Y K + LRC E + S
Sbjct: 668 PEVSFADSAWHCVAIVHVPGRRPFSQNLVHVYKDGHLVKTAPLRCPSLSEPFSSCCIGSA 727
Query: 328 GEITWFVNTS-----------------------------------------DTFDKCFLG 346
G T T + D G
Sbjct: 728 GYRTTTTTTGLPTPPVPATLAYTHPALTRSQSVPASTGLGWGSGLVAPLQEGSIDSTLAG 787
Query: 347 SSETADANRVFC-GQMTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHK 405
+ +T + G++ AV +F EAL A + + LG T FK E +L
Sbjct: 788 TQDTRWGSPTSLEGELGAVAIFHEALQATALRTLCTLGPNE--TAPFKPEGELH------ 839
Query: 406 LLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQS 465
+LS+ + Y+P+A +CL+ SP + + H + DVK V+
Sbjct: 840 ------ELSTRLLLHYSPQACKNNICLDLSPSHGLDGRL-TGHRVETWDVKDVV------ 886
Query: 466 AMHSIGGVQVLFPLFAQ---------------------------------LDYRQYLSDE 492
+ +GG+ L PL + L + +
Sbjct: 887 --NCVGGMGALLPLLERVAAQPKEAEAGPAETHDLVGPELTSGHNTQGLVLPLGKSSEER 944
Query: 493 IDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFS 552
++ + L + L+ + QE ++ C+G +IG L K + VL
Sbjct: 945 MERNAVAAFLLMLRNFLQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLM 1004
Query: 553 KYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVG 612
+ ++ +G PLL L H+L N +W + V+L Y+S+ +R+
Sbjct: 1005 EQVAAEGSG-PLLYLLYQHLLFNFHLWTLSDFAVRLGHIQYMSSI---VREHRQKLRKKY 1060
Query: 613 TVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSL-RAFLLMFIKQLVMKDSG 671
V I+ L+ +Y +PQ P D R Q +L L R FL ++ L D
Sbjct: 1061 GVQFILDALRTHY---SPQRE---RPLAADDLRTVQTSLLGLAREFL---VRSLSADDVQ 1111
Query: 672 VKEDELQAILNYLLTMHEDDNLMDVLQLLVALM 704
V Q +L++L +D + L LL+AL+
Sbjct: 1112 V----TQTMLSFLAATGDDGQAVGALDLLLALL 1140
>gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens]
Length = 1335
Score = 455 bits (1171), Expect = e-127
Identities = 346/1090 (31%), Positives = 533/1090 (48%), Gaps = 157/1090 (14%)
Query: 1796 ITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGT---SLVCMKSSSSVVE 1852
I +LEH L ++ EI+ P L RTL+ S ELL SL SSS E
Sbjct: 324 ILGKLEHVLSQSIKEQTEIYSFLIP-LVRTLV-SKIYELLFMNLHLPSLPFTNGSSSFFE 381
Query: 1853 LVMLLC-SQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVA------NEAEFILSR 1905
C S EWQ I+K + +++ + T D +A EA +
Sbjct: 382 DFQEYCNSNEWQVYIEKYI-VPYMKQYE-----AHTFYDGHENMALYWKDCYEALMVNMH 435
Query: 1906 QR-AEDIHRHAEFESLCAQ-YSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINI-LT 1962
+R E +F+ L + ++ R++ +++++ + T + K I + LT
Sbjct: 436 KRDREGGESKLKFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRW--KAIQLYLT 493
Query: 1963 DKHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLR 2022
+ G W P+ W+L E+ R R + V N TH EA+ LR
Sbjct: 494 CERGPWAKRK-QNPIH-WKLANVENYSRMRLKLVPNYNFKTHEEASA-----------LR 540
Query: 2023 EN-----SKATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGP 2077
+N S+ + + +L + + ++ + + L E D +VDEK+ ++
Sbjct: 541 DNLGIQHSQPSSDTLLLEVVKQVKVSDMVEDKLD---LPEEDITARVNVDEKEEQDQKEK 597
Query: 2078 VSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTE 2137
+ L +L+ V+ G L +T+ +YF D + +K D G KW ++
Sbjct: 598 LVLMEDCELITIIDVIPGRLEITTQHIYFY----DGSIEKEDGV------GFDFKWPHSQ 647
Query: 2138 IRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRI 2197
IR I RRY L+ +ALEIF ++ NF K L + +G
Sbjct: 648 IREIHLRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKIYSRLLSLHSPNSYYGS------ 701
Query: 2198 SLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEE 2257
SP++LFKAS +TQ+W +REISNF+YL+ +NT+AGR+YNDL QYPVFPW++ +Y SEE
Sbjct: 702 --RSPQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEE 759
Query: 2258 LDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQ--VPKFHYGTHYSTASFVLAWL 2315
LDL P FRDLSKPIG +N K A E+YE++ED + KFHYGTHYS ++ V+ +L
Sbjct: 760 LDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYL 819
Query: 2316 LRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFN 2375
+R+EPFTT + LQ G+FD ADR F SI W+ + D+KELIPEF+Y PE N N
Sbjct: 820 IRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFPEFLENQN 879
Query: 2376 NYNLGVMD-DGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQG 2434
+NLG + +V+DV LP WAK++E+F++ +R ALESE+VS LH+WIDLIFGYKQ+G
Sbjct: 880 QFNLGRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRG 939
Query: 2435 PEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQ 2494
P AV ALNVFYY +YEGAV+L+++TD R+A+E I +FG
Sbjct: 940 PAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFG------------------- 980
Query: 2495 VSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKW---- 2550
Q +LK IT++ N + + W
Sbjct: 981 -----------QTPCQLLK-----------------------ITISMNYVIGTHGWLPYD 1006
Query: 2551 HNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYI 2610
N+ + ++DQ P +R I +++ S+ FV++ D + +
Sbjct: 1007 RNISNYFTFIKDQTVTNPKT------------QRSINGSFAPGLEITSKLFVVSHDAKLL 1054
Query: 2611 LVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWY 2670
G+WD S +V S G++I + H D+VTCLA Y G +++SGSRD T ++W
Sbjct: 1055 FSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLA--TDYCG--IHLISGSRDTTCMIW- 1109
Query: 2671 WNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSM-NGD 2729
+ + G P + P IL GH EV + EL + +SGS++G +IH++ G
Sbjct: 1110 ---QITQQGGVPVGLASKPFQILYGHTNEVLSVGISTELDMAVSGSRDGTVIIHTIQKGQ 1166
Query: 2730 LLRTLEGP-ENCLKPKL--IQASREGHCVIF---------YENGLFCTFSVNGKLQATME 2777
+RTL P E+ L + + S EGH V++ + FS+NGK +
Sbjct: 1167 YMRTLRPPCESSLFLTIPNLAISWEGHIVVYSSTEEKTTLKDKNALHLFSINGKYLGSQI 1226
Query: 2778 TDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCII 2837
+ + I + G++++TG +G + +R + L I + ++ + I+
Sbjct: 1227 LKEQVSDICII--GEHIVTGSIQGFLSIRDLHSLNLSINPLAMRLPIHCVCVTKEYSHIL 1284
Query: 2838 SGMASGSIVL 2847
G+ G +++
Sbjct: 1285 VGLEDGKLIV 1294
>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 3526
Score = 365 bits (938), Expect = e-100
Identities = 221/576 (38%), Positives = 310/576 (53%), Gaps = 67/576 (11%)
Query: 2135 FTEIRSIFSRRYLLQNTALEIF--------------MANRVAVMFNFPDPATV---KKVV 2177
+ +I+ + RRYLLQ A+E+F + N+V F P+ + V
Sbjct: 2611 YEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVS 2670
Query: 2178 NYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSY 2237
P V GL T L ++TQRW+ EISNF+YLM LNT+AGRSY
Sbjct: 2671 GQRPNTSVEQGSGLLST----------LVGEKSVTQRWERGEISNFQYLMHLNTLAGRSY 2720
Query: 2238 NDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWED--DQ 2295
NDL QYPVFPW++ +Y+SEE+DLT P FR+L+KP+GA +R A + +RY+ WED +
Sbjct: 2721 NDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGE 2780
Query: 2296 VPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRN-SQRDT 2354
P +HYGTHYS+A V ++L+R+EPFT FL LQGG FD ADR F S+ AW + S+ +
Sbjct: 2781 TPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNM 2840
Query: 2355 SDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAK-TSEEFVHINRLALES 2413
+D+KELIPEF+YLPE N NN++LG +GT + DV LPPWAK EF+ ++R ALE
Sbjct: 2841 ADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALEC 2900
Query: 2414 EFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRS 2473
++VS LH+WIDLIFGYKQQGP AV A+NVF++L YEG V++ +I DP+ A I +
Sbjct: 2901 DYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINN 2960
Query: 2474 FGQTPSQLLIEPHPPR---------GSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVA 2524
FGQ P QL +PHPP+ + + V P +DK + L+ PS +PV +
Sbjct: 2961 FGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLR-PSLTPVKELK 3019
Query: 2525 ANTQPGLAT-PAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHR 2583
+ T ++ V N++ W+ A A ++ G +
Sbjct: 3020 EPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYAD--------------LSCRLGTYE 3065
Query: 2584 RQITDLLDQSIQVHSQCFVITSDNRYILVCG-------FWDKSFRVYSTDTGRLIQVVFG 2636
+ + + Q N +++ G W+ T L Q + G
Sbjct: 3066 SDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLKQALLG 3125
Query: 2637 HWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWN 2672
H D VTC S +Y I+SGSRD T ++W N
Sbjct: 3126 HTDTVTCATASLAY----HIIVSGSRDRTCIIWDLN 3157
Score = 37.0 bits (84), Expect = 0.28
Identities = 24/137 (17%), Positives = 50/137 (36%), Gaps = 22/137 (16%)
Query: 2602 VITSDNRYILVCGFWDKSFR-----------VYSTDTGRLIQVVFGHWDVVTCLARSESY 2650
++ + +L+ W+K+F Y +D + W + C
Sbjct: 3032 ILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMTVYECLSEWGQILCAICPNPK 3091
Query: 2651 IGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELG 2710
+ +++G + +W ++T + L GH VTCA
Sbjct: 3092 L-----VITGGTSTVVCVWEMGTS------KEKAKTVTLKQALLGHTDTVTCATASLAYH 3140
Query: 2711 LVLSGSQEGPCLIHSMN 2727
+++SGS++ C+I +N
Sbjct: 3141 IIVSGSRDRTCIIWDLN 3157
>gi|191252801 WDFY family member 4 [Homo sapiens]
Length = 3184
Score = 341 bits (875), Expect = 5e-93
Identities = 296/976 (30%), Positives = 437/976 (44%), Gaps = 154/976 (15%)
Query: 1941 AAKYRDHVT--------ATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDLRRR 1992
A+ Y+DHV A +I L + G W ++P W LD+ E R R
Sbjct: 2239 ASLYKDHVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMR 2298
Query: 1993 RRFVR-NPL----GSTHPEATLK------TAVEHVCIFKLRENSKATDE--------DIL 2033
+R R +PL H E+ K T E+ LRE DE
Sbjct: 2299 KRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFF 2358
Query: 2034 AKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLS-TPAQLVAPSVV 2092
+S+ S+ E +++L+ + D E + SL LV+ V+
Sbjct: 2359 PALHESLHSEDFLELCRERQVILQ---------ELLDKEKVTQKFSLVIVQGHLVSEGVL 2409
Query: 2093 VKG----------TLSVTSSEL---YFEVDEEDP---NFKKIDPKILAYTEGLHGKWLFT 2136
+ G TLS T + + DP N D Y+ H +
Sbjct: 2410 LFGHQHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHS---YA 2466
Query: 2137 EIRSIFSRRYLLQNTALEIFMAN---RVAVMFNFPDPATVKKVVNYLPRV-GVGTSFGLP 2192
++R + R+LLQ+ ALEIF N + V +N K ++ P + G TS
Sbjct: 2467 DMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTL 2526
Query: 2193 QTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITN 2252
RR S R M Q+WQ R+ISNFEYLM+LNT AGR+ ND QYPVFPWV+ +
Sbjct: 2527 SLRRYP-GSDRI------MLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLAD 2579
Query: 2253 YESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERY---ESWEDDQVPKFHYGTHYSTAS 2309
Y SE L+L P FRDLSKP+GA +R F +R+ E E D + HY THYS+A
Sbjct: 2580 YTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAI 2639
Query: 2310 FVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDT-SDIKELIPEFYYLP 2368
V ++L+R+ PFT F LQGG FD ADR F S+ W ++ R+ SD++EL PEF+YLP
Sbjct: 2640 IVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLP 2699
Query: 2369 EMFVNFNNYNLGVMDDGTVVSDVELPPWAKTS-EEFVHINRLALESEFVSCQLHQWIDLI 2427
E N N G M DGTV+ DV+LPPWA +F+ ++R ALES+FVS LH WIDLI
Sbjct: 2700 EFLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLI 2759
Query: 2428 FGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHP 2487
FGYKQQGP AV A+N+F+ Y ++L+SITDP+++ + + +FGQ P QL +PHP
Sbjct: 2760 FGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHP 2819
Query: 2488 PRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAV 2547
R +A + P +DV + P + + + P+ +TV LF++
Sbjct: 2820 ARTAAGKPLP-------GKDVSTPVSLPGHPQPFFYSLQS----LRPSQVTVKDMYLFSL 2868
Query: 2548 NKWHNLPAHQGAVQDQPYQLPVE-----IDPL-----------IASNTGMHRRQITDLLD 2591
A V + L VE + PL + G + +
Sbjct: 2869 GSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTF 2928
Query: 2592 QSIQVHSQCF--------VITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTC 2643
+++ +C I + +VC W+ S RL Q ++GH VTC
Sbjct: 2929 ENLAAWGRCLCAVCPSPTTIVTSGTSTVVC-VWELSMTKGRPRGLRLRQALYGHTQAVTC 2987
Query: 2644 LARSESYIGGNCYILSGSRDATLLLWYWNG---------------------------KCS 2676
LA S ++ ++SGS+D T +LW + C+
Sbjct: 2988 LAASVTF----SLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCA 3043
Query: 2677 GIGDNPGSETAAPRAILT---GHDYEVTCAAVCA-----ELGLVLSGSQEGPCLIHSMNG 2728
G + + P A +T G + +TC + ++++GSQ+G +
Sbjct: 3044 GAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTE- 3102
Query: 2729 DLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQAT---METDDNIRAI 2785
D+ ++ G +P S GH +E L + ++ + T +T + A+
Sbjct: 3103 DVKMSVPGRPAGEEPPAQPPSPRGH---KWEKNLALSRELDVSIALTGKPSKTSPAVTAL 3159
Query: 2786 QLSRDGQYLLTGGDRG 2801
+SR+ LL G +RG
Sbjct: 3160 AVSRNHTKLLVGDERG 3175
Score = 37.4 bits (85), Expect = 0.21
Identities = 37/143 (25%), Positives = 59/143 (41%), Gaps = 12/143 (8%)
Query: 2690 RAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQAS 2749
R L GH VTC A L++SGSQ+ C++ ++ L P + I S
Sbjct: 2975 RQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLD-HLTHVTRLPAHREGISAITIS 3033
Query: 2750 REGHCVIFYENGLFCTFSVNGKLQATMET----DDNIRAIQLSR-----DGQYLLTGGDR 2800
++ ++VNG+ A++ T + I L Q ++TG
Sbjct: 3034 DVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQD 3093
Query: 2801 GVVVVRQVSDLKQLFAYPGCDAG 2823
G+V V + D+K + PG AG
Sbjct: 3094 GMVRVWKTEDVK--MSVPGRPAG 3114
>gi|31543297 neutral sphingomyelinase (N-SMase) activation associated
factor isoform 1 [Homo sapiens]
Length = 917
Score = 312 bits (800), Expect = 3e-84
Identities = 246/806 (30%), Positives = 381/806 (47%), Gaps = 93/806 (11%)
Query: 2064 SSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKIL 2123
+S D+ +N++ + + A++V P V G + +T + LYF+ P ++
Sbjct: 180 TSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPK------PVV 233
Query: 2124 AYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVA---VMFNFPDPATVKKVVNYL 2180
T ++R I+ RR+ L LE+F + F +P + Y+
Sbjct: 234 QIT--------LQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYI 285
Query: 2181 PRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDL 2240
L A + +WQ +SN++YL+ LN +A RS NDL
Sbjct: 286 ATY---------------LEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDL 330
Query: 2241 NQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFH 2300
+QYPVFPW+I +Y S ELDL+ P FRDLSKP+GALN +R RY+ + PKF
Sbjct: 331 SQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPE---PKFM 387
Query: 2301 YGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKEL 2360
YG+HYS+ +VL +L+RI P Y L LQ G+FD+ADR F+SI+ W+N +D KEL
Sbjct: 388 YGSHYSSPGYVLFYLVRIAP--EYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKEL 445
Query: 2361 IPEFYYLPEMF-VNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQ 2419
IPEFY F VN +LG G +V DVELPPWA + E+F+ ++ ALES +VS
Sbjct: 446 IPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEH 505
Query: 2420 LHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPS 2479
LH+WIDLIFGYKQ+G +AV A NVF+ LTYEG V+LNSI DP + A+ QI FGQTP
Sbjct: 506 LHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPK 565
Query: 2480 QLLIEPHPPR--------------GSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAA 2525
QL + PHP R ++M SP +++ +D+ K + + +T +
Sbjct: 566 QLFVTPHPRRITPKFKSLSQTSSYNASMADSP---GEESFEDLTEESKTLAWNNITKLQL 622
Query: 2526 NTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQ 2585
+ + AV +T +R N + QD + + + + M +R
Sbjct: 623 HEHYKIHKEAVTGITVSR--------NGSSVFTTSQDSTLK-------MFSKESKMLQRS 667
Query: 2586 ITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLA 2645
I+ S S C ++ D ++ WD + YS GR + GH D V+ +
Sbjct: 668 IS----FSNMALSSCLLLPGD--ATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKIC 721
Query: 2646 RSESYIGGNCYILSGSRDATLLLWYWNGKCSGI-GDNPGSETAAPRAIL-TGHDYEVTCA 2703
++ + S S D+T+ +W SG+ + PG++ + HD V
Sbjct: 722 WHDN------RLYSASWDSTVKVW------SGVPAEMPGTKRHHFDLLAELEHDVSVDTI 769
Query: 2704 AVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLF 2763
++ A L++SG++EG I + L + + + H + +G
Sbjct: 770 SLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCL 829
Query: 2764 CTFSV-NGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDA 2822
V G L ++M +D+ R DG +L+G G ++V + K G
Sbjct: 830 NVIDVQTGMLISSMTSDEPQRCFVW--DGNSVLSGSQSGELLVWDLLGAKISERIQGHTG 887
Query: 2823 GIRAMALSYDQRCIISGMASGSIVLF 2848
+ + ++ II+G I+ +
Sbjct: 888 AVTCIWMNEQCSSIITGGEDRQIIFW 913
>gi|221625547 neutral sphingomyelinase (N-SMase) activation associated
factor isoform 2 [Homo sapiens]
Length = 948
Score = 312 bits (800), Expect = 3e-84
Identities = 246/806 (30%), Positives = 381/806 (47%), Gaps = 93/806 (11%)
Query: 2064 SSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKIL 2123
+S D+ +N++ + + A++V P V G + +T + LYF+ P ++
Sbjct: 211 TSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPK------PVV 264
Query: 2124 AYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVA---VMFNFPDPATVKKVVNYL 2180
T ++R I+ RR+ L LE+F + F +P + Y+
Sbjct: 265 QIT--------LQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYI 316
Query: 2181 PRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDL 2240
L A + +WQ +SN++YL+ LN +A RS NDL
Sbjct: 317 ATY---------------LEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDL 361
Query: 2241 NQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFH 2300
+QYPVFPW+I +Y S ELDL+ P FRDLSKP+GALN +R RY+ + PKF
Sbjct: 362 SQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPE---PKFM 418
Query: 2301 YGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKEL 2360
YG+HYS+ +VL +L+RI P Y L LQ G+FD+ADR F+SI+ W+N +D KEL
Sbjct: 419 YGSHYSSPGYVLFYLVRIAP--EYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKEL 476
Query: 2361 IPEFYYLPEMF-VNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQ 2419
IPEFY F VN +LG G +V DVELPPWA + E+F+ ++ ALES +VS
Sbjct: 477 IPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEH 536
Query: 2420 LHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPS 2479
LH+WIDLIFGYKQ+G +AV A NVF+ LTYEG V+LNSI DP + A+ QI FGQTP
Sbjct: 537 LHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPK 596
Query: 2480 QLLIEPHPPR--------------GSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAA 2525
QL + PHP R ++M SP +++ +D+ K + + +T +
Sbjct: 597 QLFVTPHPRRITPKFKSLSQTSSYNASMADSP---GEESFEDLTEESKTLAWNNITKLQL 653
Query: 2526 NTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQ 2585
+ + AV +T +R N + QD + + + + M +R
Sbjct: 654 HEHYKIHKEAVTGITVSR--------NGSSVFTTSQDSTLK-------MFSKESKMLQRS 698
Query: 2586 ITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLA 2645
I+ S S C ++ D ++ WD + YS GR + GH D V+ +
Sbjct: 699 IS----FSNMALSSCLLLPGD--ATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKIC 752
Query: 2646 RSESYIGGNCYILSGSRDATLLLWYWNGKCSGI-GDNPGSETAAPRAIL-TGHDYEVTCA 2703
++ + S S D+T+ +W SG+ + PG++ + HD V
Sbjct: 753 WHDN------RLYSASWDSTVKVW------SGVPAEMPGTKRHHFDLLAELEHDVSVDTI 800
Query: 2704 AVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLF 2763
++ A L++SG++EG I + L + + + H + +G
Sbjct: 801 SLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCL 860
Query: 2764 CTFSV-NGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDA 2822
V G L ++M +D+ R DG +L+G G ++V + K G
Sbjct: 861 NVIDVQTGMLISSMTSDEPQRCFVW--DGNSVLSGSQSGELLVWDLLGAKISERIQGHTG 918
Query: 2823 GIRAMALSYDQRCIISGMASGSIVLF 2848
+ + ++ II+G I+ +
Sbjct: 919 AVTCIWMNEQCSSIITGGEDRQIIFW 944
>gi|54292123 lysosomal trafficking regulator [Homo sapiens]
Length = 3801
Score = 267 bits (683), Expect = 1e-70
Identities = 192/578 (33%), Positives = 288/578 (49%), Gaps = 68/578 (11%)
Query: 1930 EDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDL 1989
E +K+ H+ Y+ ++A++ Q++I LT W + + P W+LD E
Sbjct: 2901 ERKKVIQHI--RGMYKVDLSASRHWQELIQQLTHDRAVWYDP-IYYPTS-WQLDPTEGPN 2956
Query: 1990 RRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQALGNQN 2049
R RRR R L T P L LR+ K+ ED++ +
Sbjct: 2957 RERRRLQRCYL--TIPNKYL-----------LRDRQKS--EDVVKPPLSYLF-------- 2993
Query: 2050 SENEILLEGDDDTLSSVDEKDLENLAGP-VSLSTPAQLVAPSVVVKGTLSVTSSELYFEV 2108
+D T SS + A + ++ VAPS G L + +YF
Sbjct: 2994 ---------EDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVE 3044
Query: 2109 DEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFP 2168
D + + E W + EI+ + R + L++ A+EIF+ N ++ F
Sbjct: 3045 DNASDTVES--SSLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFD 3102
Query: 2169 DPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMF 2228
+ V + + + LP + +T W +I+NFEYL
Sbjct: 3103 NTKVRDDVYHNI------LTNNLPNLLEYG--------NITALTNLWYTGQITNFEYLTH 3148
Query: 2229 LNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERY 2288
LN AGRS+NDL QYPVFP+++ +Y SE LDL +R+LSKPI ++ + + Y
Sbjct: 3149 LNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIAVQYKEKEDRYVDTY 3208
Query: 2289 E---------SWEDDQVP---KFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHA 2336
+ + EDD +P +HYG+HYS + VL +L+R+ PFT FL Q FD
Sbjct: 3209 KYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIP 3268
Query: 2337 DRTFSSISRAWR-NSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPP 2395
DRTF S + WR +S +D+KELIPEF+YLPE VN ++ GV +G V+ V LPP
Sbjct: 3269 DRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPP 3328
Query: 2396 WAKTSEE-FVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVN 2454
WA+ F+ I+R ALES++VS + QWIDL+FGYKQ+G +V+A+NVF+ TY G ++
Sbjct: 3329 WARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFG-MD 3387
Query: 2455 LNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSA 2492
++++ DPV R A+E I+++GQTP QL H R A
Sbjct: 3388 VSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGA 3425
Score = 37.0 bits (84), Expect = 0.28
Identities = 50/250 (20%), Positives = 99/250 (39%), Gaps = 22/250 (8%)
Query: 2610 ILVCGFWDKSFRVYSTDTGRLIQVVFG--HWDVVTCLARSESYIGGNCYILSGSRDATLL 2667
IL G+ D R+ S + + + + V +C +++ +C + +GS+ +
Sbjct: 3536 ILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVTSC-----AWVPDSCQLFTGSKCGVIT 3590
Query: 2668 LWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMN 2727
Y N S ET + L GH E+T VC +++S S++G C+I +N
Sbjct: 3591 A-YTNRFTSSTPSEIEMET---QIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLN 3646
Query: 2728 G----DLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIR 2783
L + P + C ++VNG L + + I
Sbjct: 3647 RLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIIC 3706
Query: 2784 AIQLSRDGQ----YLLTGG-DRGVVVVRQVSDLKQL--FAYPGCDAGIRAMALSYDQRCI 2836
++ S + ++ GG + G+V + DLK + +P + I ++ S D +
Sbjct: 3707 SVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHL 3766
Query: 2837 ISGMASGSIV 2846
+ + G+++
Sbjct: 3767 YTANSDGTVI 3776
Score = 34.7 bits (78), Expect = 1.4
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 23/180 (12%)
Query: 976 TKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLE 1035
T+ +P T+ +S++ LE+ I L TS ++M+ E NQ L E L
Sbjct: 1081 TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILF 1140
Query: 1036 ETLTNETRN-ADDLEVSSDIIEA---VAISSNSFITTGKDSMTV-----SEVTASISSPS 1086
E + +++ + +++ + +A VA+ + S D+MT +E +S
Sbjct: 1141 EMRDHLSQSKVIETQLAKPLFDALLRVALGNYSADFEHNDAMTEKSHQSAEELSSQPGDF 1200
Query: 1087 EEDASEMPEFLDKSIVEEE----------ED----DDYVELKVEGSPTEEANLPTELQDN 1132
E+A + K +VEEE ED DD V+LK E ++ P +L +N
Sbjct: 1201 SEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN 1260
>gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 105 bits (262), Expect = 6e-22
Identities = 93/287 (32%), Positives = 120/287 (41%), Gaps = 59/287 (20%)
Query: 2215 WQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTN-FRDLSKPI 2273
W H ISNF YLM LN +AGR D N +PV PWV+ D T P FRDL K
Sbjct: 352 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGRFRDLRKSK 403
Query: 2274 GALNP-----------KRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFT 2322
LN R AF A E VP H S ++ + + R P +
Sbjct: 404 FRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPH-HISDVLSDITYYV-YKARRTPRS 461
Query: 2323 TYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVM 2382
+++ H + W T D E IPEFY P +F + +
Sbjct: 462 VLCGHVRAQWEPHEYPASMERMQNW------TPD--ECIPEFYTDPSIFRSIH------- 506
Query: 2383 DDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALN 2442
+ D+++P W +S+EFV +R LES VS LH WIDL FGYK QG EAV+ N
Sbjct: 507 ---PDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKN 563
Query: 2443 VFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPR 2489
V +L + S+G QL +PHP R
Sbjct: 564 VCLHLV-----------------DAHTHLASYGVV--QLFDQPHPQR 591
>gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 2240
Score = 105 bits (262), Expect = 6e-22
Identities = 93/287 (32%), Positives = 120/287 (41%), Gaps = 59/287 (20%)
Query: 2215 WQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTN-FRDLSKPI 2273
W H ISNF YLM LN +AGR D N +PV PWV+ D T P FRDL K
Sbjct: 651 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGRFRDLRKSK 702
Query: 2274 GALNP-----------KRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFT 2322
LN R AF A E VP H S ++ + + R P +
Sbjct: 703 FRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPH-HISDVLSDITYYV-YKARRTPRS 760
Query: 2323 TYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVM 2382
+++ H + W T D E IPEFY P +F + +
Sbjct: 761 VLCGHVRAQWEPHEYPASMERMQNW------TPD--ECIPEFYTDPSIFRSIH------- 805
Query: 2383 DDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALN 2442
+ D+++P W +S+EFV +R LES VS LH WIDL FGYK QG EAV+ N
Sbjct: 806 ---PDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKN 862
Query: 2443 VFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPR 2489
V +L + S+G QL +PHP R
Sbjct: 863 VCLHLV-----------------DAHTHLASYGVV--QLFDQPHPQR 890
>gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 105 bits (262), Expect = 6e-22
Identities = 93/287 (32%), Positives = 120/287 (41%), Gaps = 59/287 (20%)
Query: 2215 WQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTN-FRDLSKPI 2273
W H ISNF YLM LN +AGR D N +PV PWV+ D T P FRDL K
Sbjct: 352 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGRFRDLRKSK 403
Query: 2274 GALNP-----------KRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFT 2322
LN R AF A E VP H S ++ + + R P +
Sbjct: 404 FRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPH-HISDVLSDITYYV-YKARRTPRS 461
Query: 2323 TYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVM 2382
+++ H + W T D E IPEFY P +F + +
Sbjct: 462 VLCGHVRAQWEPHEYPASMERMQNW------TPD--ECIPEFYTDPSIFRSIH------- 506
Query: 2383 DDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALN 2442
+ D+++P W +S+EFV +R LES VS LH WIDL FGYK QG EAV+ N
Sbjct: 507 ---PDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKN 563
Query: 2443 VFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPR 2489
V +L + S+G QL +PHP R
Sbjct: 564 VCLHLV-----------------DAHTHLASYGVV--QLFDQPHPQR 591
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 58.5 bits (140), Expect = 9e-08
Identities = 49/270 (18%), Positives = 109/270 (40%), Gaps = 5/270 (1%)
Query: 968 SVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQE 1027
S S D+ DS + + N + S + + S +S+ + + ++ S E + +
Sbjct: 1034 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNS 1093
Query: 1028 LPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSE 1087
+ + + ++++ ++ D SSD + S +S + DS S+ + S S
Sbjct: 1094 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDS 1153
Query: 1088 EDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDM 1147
D+S+ + D S + D + S + +++ ++ D+S S +S++ + D
Sbjct: 1154 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1213
Query: 1148 FGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQ 1207
+ D + ++ +++ DS DS + ++ S + + S ESD
Sbjct: 1214 SDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESD--- 1270
Query: 1208 MLEEGKKATNLTRETKLINDCHGSVSEASS 1237
+ K + +D GS S S+
Sbjct: 1271 --SQSKSGNGNNNGSDSDSDSEGSDSNHST 1298
Score = 58.2 bits (139), Expect = 1e-07
Identities = 54/304 (17%), Positives = 126/304 (41%), Gaps = 2/304 (0%)
Query: 951 SSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQ 1010
S++S + S + S S D+ DS + + N + S + + S +S+++ +
Sbjct: 963 SNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSS 1022
Query: 1011 TTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGK 1070
++ S + + + + + ++++ N+ D SSD ++ S +S +
Sbjct: 1023 NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1082
Query: 1071 DSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQ 1130
+S S+ + S S D+S+ + D S + D + S + +++ +
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 1142
Query: 1131 DNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAM 1190
D+S S +S++ + D + D + ++ +++ DS DS + +S SS
Sbjct: 1143 DSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS-DSSDSSDSSDS 1201
Query: 1191 SPETTVSQIAVESDLGQMLEEGKKA-TNLTRETKLINDCHGSVSEASSEQKIAKLDVSNV 1249
S + S + SD + + ++ + E+ +D S ++S D S+
Sbjct: 1202 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDS 1261
Query: 1250 ATDT 1253
+D+
Sbjct: 1262 TSDS 1265
Score = 57.0 bits (136), Expect = 3e-07
Identities = 49/254 (19%), Positives = 108/254 (42%), Gaps = 2/254 (0%)
Query: 951 SSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQ 1010
S +S + S N S S ++ DS + + N N + S + S +S+ +
Sbjct: 895 SDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSS 954
Query: 1011 TTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGK 1070
++ S + + + + + + + ++++ ++ D SSD ++ S +S +
Sbjct: 955 DSSNSSDSSNSSDSSDSNSSDSS-DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013
Query: 1071 DSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQ 1130
DS S+ + S S + D+S+ + D S + D + S + +++ ++
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1073
Query: 1131 DNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAM 1190
D+S S +SE+ + D + D + ++ +++ DS DS + +S SS
Sbjct: 1074 DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS-NSSDSSDSSDS 1132
Query: 1191 SPETTVSQIAVESD 1204
S + S + SD
Sbjct: 1133 SDSSDSSNSSDSSD 1146
Score = 55.5 bits (132), Expect = 8e-07
Identities = 58/298 (19%), Positives = 122/298 (40%), Gaps = 5/298 (1%)
Query: 951 SSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQ 1010
SS S ++ D N S S D+ DS ++ + NSS SS S S+
Sbjct: 560 SSDSSDSSDSDSSDSNSSSDSDSSDS-DSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSD 618
Query: 1011 TTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGK 1070
++++ + K+E ++ D + ++ + + ++ D SSD + S +S +
Sbjct: 619 SSDSKSDSSKSESDSS---DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSS 675
Query: 1071 DSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQ 1130
DS + S+ + S S D+S E D S + + D + S +++ ++
Sbjct: 676 DSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735
Query: 1131 DNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAM 1190
D+S S +S++ + + + D ++ +++ DS +S + +S SS
Sbjct: 736 DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS-DSNDSSNSSDS 794
Query: 1191 SPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSN 1248
S + S + SD + ++ + ++ +D S + + S D S+
Sbjct: 795 SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSD 852
Score = 55.1 bits (131), Expect = 1e-06
Identities = 61/311 (19%), Positives = 130/311 (41%), Gaps = 6/311 (1%)
Query: 951 SSTSVQAASGIRRDI-NVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIEL 1009
SS S ++ G D N S S D+ DS + + + + + S E ++S +S+ +
Sbjct: 841 SSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNS 900
Query: 1010 QTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTG 1069
+++S ++ + + + E + +++ N+ D SSD ++ S++S +
Sbjct: 901 SDSDSSDSSNSSDSSDSSNSSDSS-ESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNS 959
Query: 1070 KDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTEL 1129
DS S+ + S SS S D+S + D S + D + S + +++ +
Sbjct: 960 SDSSNSSDSSDSNSSDSS-DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNS 1018
Query: 1130 QDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDS--GIQTMTASGS 1187
D+S S +S + + D + D + ++ +++ DS DS + +S S
Sbjct: 1019 SDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1078
Query: 1188 SAMSPETTVSQIAVESDLGQMLEEGKKA-TNLTRETKLINDCHGSVSEASSEQKIAKLDV 1246
S S + S + SD + + ++ + ++ +D S + S D
Sbjct: 1079 SDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1138
Query: 1247 SNVATDTERLE 1257
SN + ++ E
Sbjct: 1139 SNSSDSSDSSE 1149
Score = 55.1 bits (131), Expect = 1e-06
Identities = 48/254 (18%), Positives = 107/254 (42%), Gaps = 1/254 (0%)
Query: 951 SSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQ 1010
S++S + S D N S S ++ DS + + + + S + S +S+ + +
Sbjct: 957 SNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1016
Query: 1011 TTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGK 1070
++ S + + + + + ++++ ++ D SSD ++ S +S +
Sbjct: 1017 NSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1076
Query: 1071 DSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQ 1130
DS SE + S S + D+S+ + D S + D S + +++ ++
Sbjct: 1077 DSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1136
Query: 1131 DNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAM 1190
D+S S +S++ E D + D + ++ +++ +S DS + +S SS
Sbjct: 1137 DSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS-DSSDSSDSSDS 1195
Query: 1191 SPETTVSQIAVESD 1204
S + S + SD
Sbjct: 1196 SDSSDSSDSSDSSD 1209
Score = 51.6 bits (122), Expect = 1e-05
Identities = 53/287 (18%), Positives = 121/287 (42%), Gaps = 4/287 (1%)
Query: 968 SVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQE 1027
S S D+ DS ++ +SS + S S SN + N+ + + +
Sbjct: 608 SDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSD 667
Query: 1028 LPDEG-TLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPS 1086
D + + + ++++ N+ D SSD + + SS+S ++ DS S+ +S S+ S
Sbjct: 668 SSDSSDSSDSSSSSDSSNSSDSSDSSDSSNS-SESSDSSDSSDSDSSDSSD--SSNSNSS 724
Query: 1087 EEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLD 1146
+ D+S + D S + D + S + +++ ++ D+S S +S++ D
Sbjct: 725 DSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 784
Query: 1147 MFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLG 1206
+ + + ++ +++ DS DS + S S+ S +++ S + +S
Sbjct: 785 SNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDS 844
Query: 1207 QMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDT 1253
+G + + R + S++S+ + SN ++++
Sbjct: 845 SDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNS 891
Score = 50.8 bits (120), Expect = 2e-05
Identities = 48/254 (18%), Positives = 106/254 (41%), Gaps = 11/254 (4%)
Query: 951 SSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQ 1010
+S+ +S + N S S D+ DS + + + N + S + S +S S+
Sbjct: 919 NSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSD 978
Query: 1011 TTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGK 1070
++N+S ++ + + ++++ N+ D SSD ++ S +S +
Sbjct: 979 SSNSSDSSDSSDSS----------DSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028
Query: 1071 DSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQ 1130
+S S+ + S S D+S+ + + S + D + S + +++ ++
Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088
Query: 1131 DNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAM 1190
D+S S +S++ + D + D + + +++ DS DS + +S SS
Sbjct: 1089 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS-DSSNSSDSSDS 1147
Query: 1191 SPETTVSQIAVESD 1204
S + S + SD
Sbjct: 1148 SESSDSSDSSDSSD 1161
Score = 49.7 bits (117), Expect = 4e-05
Identities = 55/319 (17%), Positives = 128/319 (40%), Gaps = 7/319 (2%)
Query: 951 SSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQ 1010
SS S +++ D + S S D+ +S + + N + S + + S S+ + +
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771
Query: 1011 TTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAI----SSNSFI 1066
++ S + + N + + + ++++ N+ D SSD ++ + SSNS
Sbjct: 772 DSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD 831
Query: 1067 TTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLP 1126
++ + + S ++ S S+ D+S + + S + D + S + E++
Sbjct: 832 SSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNS 891
Query: 1127 TELQD--NSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTA 1184
++ D NS +S++ D + + E ++ +++ +S DS + +
Sbjct: 892 SDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS-DSSDS 950
Query: 1185 SGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKL 1244
S SS S + S + SD ++ + ++ +D S ++S
Sbjct: 951 SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1010
Query: 1245 DVSNVATDTERLELKASPN 1263
D S+ + ++ S N
Sbjct: 1011 DSSDSSNSSDSSNSSDSSN 1029
Score = 44.7 bits (104), Expect = 0.001
Identities = 52/270 (19%), Positives = 104/270 (38%), Gaps = 26/270 (9%)
Query: 968 SVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQE 1027
S G++ D+ + + +NGN N+ + +S K++ + +
Sbjct: 507 SKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKG-------------KSDSSDSD 553
Query: 1028 LPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSE 1087
D ++ + ++ D SSD + + SS+S + DS S+ + S S
Sbjct: 554 SSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDS 613
Query: 1088 EDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDM 1147
D+S+ + S E + D S + ++N ++ DNS S +S + D
Sbjct: 614 SDSSDSSDSKSDSSKSESDSSD----SDSKSDSSDSN-SSDSSDNSDSSDSSNSSNSSDS 668
Query: 1148 FGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQ 1207
+ D + ++ +++ DS DS + S S+ S +++ S + SD
Sbjct: 669 SDSSDS---SDSSSSSDSSNSSDSSDSSDS-----SNSSESSDSSDSSDSDSSDSSDSSN 720
Query: 1208 MLEEGKKATNLTRETKLINDCHGSVSEASS 1237
++N + + N S S SS
Sbjct: 721 SNSSDSDSSNSSDSSDSSNSSDSSDSSDSS 750
Score = 37.4 bits (85), Expect = 0.21
Identities = 46/252 (18%), Positives = 108/252 (42%), Gaps = 10/252 (3%)
Query: 988 NGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQEL-PDEGTLEETLTNETRNAD 1046
NG+++ E S +S S+ +N + + + + + ++ ++++ N+
Sbjct: 503 NGSDSKGAEDDDS-DSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSS 561
Query: 1047 DLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEE 1106
D SSD + + SS+ ++ DS S+ +S SS S D+S+ + D S +
Sbjct: 562 DSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSS-DSSDSSDSSDSS-----D 615
Query: 1107 DDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQ 1166
D + K + S +E + ++ + +S +S++ + D + + + ++
Sbjct: 616 SSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSS 675
Query: 1167 TDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLIN 1226
+ + DS +S + S S+ S E++ S + +SD + ++ + + +
Sbjct: 676 DSSSSSDSSNS--SDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSD 733
Query: 1227 DCHGSVSEASSE 1238
S S SS+
Sbjct: 734 SSDSSNSSDSSD 745
Score = 32.0 bits (71), Expect = 9.0
Identities = 52/239 (21%), Positives = 101/239 (42%), Gaps = 5/239 (2%)
Query: 1556 NERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGL 1615
++ + S + S++ + S S+ + + S+ ++ S + S+S++S+ DS E++
Sbjct: 833 SDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSS 892
Query: 1616 GSHVEVTPHTAPPGVSAGP-DAISEVLSTLSLEVNKSPETKN--DRGNDLDTK-ATPSVS 1671
S + S+ D+ S+ S E + S + N D N D+ ++ S +
Sbjct: 893 DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSN 952
Query: 1672 VSKNVNVKDILRSLVNIPADGV-TVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAA 1730
S + N D S + ++ + D + + + S + S D S +
Sbjct: 953 SSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1012
Query: 1731 KKSAVSPSTFNTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQD 1789
S+ S + N+S +N+ S DS+ +SD S S SSN+ S + S S D
Sbjct: 1013 SDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1071
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 50.4 bits (119), Expect = 2e-05
Identities = 44/174 (25%), Positives = 72/174 (41%), Gaps = 36/174 (20%)
Query: 2610 ILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLW 2669
+L G D +++ TG L+ + GH DVV L+ + S G+ ++S SRD TL +W
Sbjct: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPS---GSLILVSASRDKTLRIW 181
Query: 2670 YWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNG- 2728
N I +L+GH V C ++ + ++ S + E + SM
Sbjct: 182 DLNKHGKQI------------QVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSY 229
Query: 2729 DLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNI 2782
L+R LEG ++ + + C FS + L T D N+
Sbjct: 230 TLIRKLEGHQSSV--------------------VSCDFSPDSALLVTASYDTNV 263
>gi|192807336 arsenate resistance protein 2 isoform e [Homo sapiens]
Length = 871
Score = 49.7 bits (117), Expect = 4e-05
Identities = 82/363 (22%), Positives = 137/363 (37%), Gaps = 56/363 (15%)
Query: 1098 DKSIVEEEEDDDYVELKVEGSPTEEANLPTELQD-----NSLSPAASEAGEKLDMFGNDD 1152
D I+E+EE+++ E S EE L D N + + + NDD
Sbjct: 264 DLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDD 323
Query: 1153 KLIFQEGK-PVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEE 1211
K EG EK+ D+E + K S + SG + E +VS+ ES+ GQ EE
Sbjct: 324 KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD-EGSVSESESESESGQAEEE 382
Query: 1212 GKKATNLTRETK-------LINDCHGSVSEASSEQKIAKLDVSNVATDTERLEL----KA 1260
++A L + K D G + K L + N+A + R E+ K
Sbjct: 383 KEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKR 442
Query: 1261 SPN-----VEAPQPHRHVLE---ISRQHEQPGQGIAPDAVNGQRRD-------SRSTVFR 1305
P + PQP R ++ + I + N + R+ +R R
Sbjct: 443 YPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRR 502
Query: 1306 IPEFNWSQMHQ-------RLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTI 1358
+ N H+ +L L+ +++ Q+W S + S N I + T
Sbjct: 503 VRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPLPTSLPSQNPILKNITD 562
Query: 1359 HLISQVM---DNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVD 1415
+LI +V + ++ + GG P P +G E +V ++LI ++D
Sbjct: 563 YLIEEVSAEEEELLGSSGGAPP-------------EEPPKEGNPAEINVERDEKLIKVLD 609
Query: 1416 VLI 1418
L+
Sbjct: 610 KLL 612
>gi|192807332 arsenate resistance protein 2 isoform c [Homo sapiens]
Length = 875
Score = 49.7 bits (117), Expect = 4e-05
Identities = 82/363 (22%), Positives = 137/363 (37%), Gaps = 56/363 (15%)
Query: 1098 DKSIVEEEEDDDYVELKVEGSPTEEANLPTELQD-----NSLSPAASEAGEKLDMFGNDD 1152
D I+E+EE+++ E S EE L D N + + + NDD
Sbjct: 264 DLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDD 323
Query: 1153 KLIFQEGK-PVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEE 1211
K EG EK+ D+E + K S + SG + E +VS+ ES+ GQ EE
Sbjct: 324 KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD-EGSVSESESESESGQAEEE 382
Query: 1212 GKKATNLTRETK-------LINDCHGSVSEASSEQKIAKLDVSNVATDTERLEL----KA 1260
++A L + K D G + K L + N+A + R E+ K
Sbjct: 383 KEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKR 442
Query: 1261 SPN-----VEAPQPHRHVLE---ISRQHEQPGQGIAPDAVNGQRRD-------SRSTVFR 1305
P + PQP R ++ + I + N + R+ +R R
Sbjct: 443 YPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRR 502
Query: 1306 IPEFNWSQMHQ-------RLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTI 1358
+ N H+ +L L+ +++ Q+W S + S N I + T
Sbjct: 503 VRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPLPTSLPSQNPILKNITD 562
Query: 1359 HLISQVM---DNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVD 1415
+LI +V + ++ + GG P P +G E +V ++LI ++D
Sbjct: 563 YLIEEVSAEEEELLGSSGGAPP-------------EEPPKEGNPAEINVERDEKLIKVLD 609
Query: 1416 VLI 1418
L+
Sbjct: 610 KLL 612
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 49.7 bits (117), Expect = 4e-05
Identities = 66/279 (23%), Positives = 109/279 (39%), Gaps = 51/279 (18%)
Query: 2601 FVITSDNRY--ILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYIL 2658
+ I +N Y + G +DK+ +++S +TG+ GH + CL S+ + +
Sbjct: 138 YAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCL----SFNPQSTLVA 193
Query: 2659 SGSRDATLLLW-YWNGK------------------------CSGIGDNP----GSETAAP 2689
+GS D T LW NG+ +G D+ ++T
Sbjct: 194 TGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK 253
Query: 2690 RAILTGHDYEVTCAAVCAELGLVLSGSQEGPC-LIHSMNGDLLRTLEGPENCL------- 2741
IL GH E++ A+ + L+L+GS + C L + NG + TL G ++ +
Sbjct: 254 VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313
Query: 2742 KPKLI-QASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDR 2800
KLI AS +G IF C + G + I I + G +LLTG
Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGH-------EGEISKISFNPQGNHLLTGSSD 366
Query: 2801 GVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISG 2839
+ + L G I + A +Y +I+G
Sbjct: 367 KTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
Score = 48.9 bits (115), Expect = 7e-05
Identities = 45/157 (28%), Positives = 67/157 (42%), Gaps = 25/157 (15%)
Query: 2585 QITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCL 2644
++ L S ++ S F + D ++ G +D + V+ DTGR + ++ GH C
Sbjct: 211 EVYTLRGHSAEIISLSFNTSGDR---IITGSFDHTVVVWDADTGRKVNILIGH-----CA 262
Query: 2645 ARSESYIGGNC-YILSGSRDATLLLW-YWNGKCSGIGDNPGSETAAPRAILTGHDYEVTC 2702
S + +C IL+GS D T LW NGKC A LTGHD E+
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCV--------------ATLTGHDDEILD 308
Query: 2703 AAVCAELGLVLSGSQEGPCLIHS-MNGDLLRTLEGPE 2738
+ L+ + S +G I S + LEG E
Sbjct: 309 SCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHE 345
Score = 40.8 bits (94), Expect = 0.019
Identities = 52/246 (21%), Positives = 94/246 (38%), Gaps = 32/246 (13%)
Query: 2612 VCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYW 2671
+ G +D++ +++ T +G + + GH +VV +A + Y I +GS D T LW
Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY---GDKIATGSFDKTCKLW-- 162
Query: 2672 NGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSM-NGDL 2730
ET GH E+ C + + LV +GS + + + NG+
Sbjct: 163 -----------SVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE 211
Query: 2731 LRTLEGPE--------NCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNI 2782
+ TL G N ++I S + H V+ ++ K+ + I
Sbjct: 212 VYTLRGHSAEIISLSFNTSGDRIITGSFD-HTVVVWD------ADTGRKVNILIGHCAEI 264
Query: 2783 RAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISGMAS 2842
+ + D +LTG + ++ K + G D I Y + I + A
Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASAD 324
Query: 2843 GSIVLF 2848
G+ +F
Sbjct: 325 GTARIF 330
Score = 36.2 bits (82), Expect = 0.48
Identities = 20/59 (33%), Positives = 34/59 (57%), Gaps = 4/59 (6%)
Query: 2611 LVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLW 2669
L+ G DK+ R++ TG+ +QV+ GH D + A +Y G +++GS+D T +W
Sbjct: 360 LLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCA--FNYKGN--IVITGSKDNTCRIW 414
Score = 34.7 bits (78), Expect = 1.4
Identities = 30/138 (21%), Positives = 59/138 (42%), Gaps = 20/138 (14%)
Query: 2586 ITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLA 2645
+ L ++ CF T ++ D + R++S T + I + GH ++ ++
Sbjct: 296 VATLTGHDDEILDSCFDYTGK---LIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 2646 RSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAV 2705
+ GN ++L+GS D T +W ++T +L GH E+ A
Sbjct: 353 FNPQ---GN-HLLTGSSDKTARIW-------------DAQTGQCLQVLEGHTDEIFSCAF 395
Query: 2706 CAELGLVLSGSQEGPCLI 2723
+ +V++GS++ C I
Sbjct: 396 NYKGNIVITGSKDNTCRI 413
>gi|192807334 arsenate resistance protein 2 isoform d [Homo sapiens]
Length = 872
Score = 48.9 bits (115), Expect = 7e-05
Identities = 81/364 (22%), Positives = 137/364 (37%), Gaps = 57/364 (15%)
Query: 1098 DKSIVEEEEDDDYVELKVEGSPTEEANLPTELQD-----NSLSPAASEAGEKLDMFGNDD 1152
D I+E+EE+++ E S EE L D N + + + NDD
Sbjct: 264 DLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDD 323
Query: 1153 KLIFQEGK-PVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEE 1211
K EG EK+ D+E + K S + SG + E +VS+ ES+ GQ EE
Sbjct: 324 KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD-EGSVSESESESESGQAEEE 382
Query: 1212 GKKATNLTRET--------KLINDCHGSVSEASSEQKIAKLDVSNVATDTERLEL----K 1259
++A +E + D G + K L + N+A + R E+ K
Sbjct: 383 KEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCK 442
Query: 1260 ASPN-----VEAPQPHRHVLE---ISRQHEQPGQGIAPDAVNGQRRD-------SRSTVF 1304
P + PQP R ++ + I + N + R+ +R
Sbjct: 443 RYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTR 502
Query: 1305 RIPEFNWSQMHQ-------RLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNT 1357
R+ N H+ +L L+ +++ Q+W S + S N I + T
Sbjct: 503 RVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPLPTSLPSQNPILKNIT 562
Query: 1358 IHLISQVM---DNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLV 1414
+LI +V + ++ + GG P P +G E +V ++LI ++
Sbjct: 563 DYLIEEVSAEEEELLGSSGGAPP-------------EEPPKEGNPAEINVERDEKLIKVL 609
Query: 1415 DVLI 1418
D L+
Sbjct: 610 DKLL 613
>gi|58331218 arsenate resistance protein 2 isoform a [Homo sapiens]
Length = 876
Score = 48.9 bits (115), Expect = 7e-05
Identities = 81/364 (22%), Positives = 137/364 (37%), Gaps = 57/364 (15%)
Query: 1098 DKSIVEEEEDDDYVELKVEGSPTEEANLPTELQD-----NSLSPAASEAGEKLDMFGNDD 1152
D I+E+EE+++ E S EE L D N + + + NDD
Sbjct: 264 DLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDD 323
Query: 1153 KLIFQEGK-PVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEE 1211
K EG EK+ D+E + K S + SG + E +VS+ ES+ GQ EE
Sbjct: 324 KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD-EGSVSESESESESGQAEEE 382
Query: 1212 GKKATNLTRET--------KLINDCHGSVSEASSEQKIAKLDVSNVATDTERLEL----K 1259
++A +E + D G + K L + N+A + R E+ K
Sbjct: 383 KEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCK 442
Query: 1260 ASPN-----VEAPQPHRHVLE---ISRQHEQPGQGIAPDAVNGQRRD-------SRSTVF 1304
P + PQP R ++ + I + N + R+ +R
Sbjct: 443 RYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTR 502
Query: 1305 RIPEFNWSQMHQ-------RLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNT 1357
R+ N H+ +L L+ +++ Q+W S + S N I + T
Sbjct: 503 RVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPLPTSLPSQNPILKNIT 562
Query: 1358 IHLISQVM---DNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLV 1414
+LI +V + ++ + GG P P +G E +V ++LI ++
Sbjct: 563 DYLIEEVSAEEEELLGSSGGAPP-------------EEPPKEGNPAEINVERDEKLIKVL 609
Query: 1415 DVLI 1418
D L+
Sbjct: 610 DKLL 613
>gi|16445033 ACRC protein [Homo sapiens]
Length = 691
Score = 48.1 bits (113), Expect = 1e-04
Identities = 66/337 (19%), Positives = 130/337 (38%), Gaps = 24/337 (7%)
Query: 978 DSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQ---ELPDEGTL 1034
+SP C H E + + + +L+ + + ++ +A +N E PD+ +
Sbjct: 105 ESPECCHVKPAIQEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSD 164
Query: 1035 EETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMP 1094
+ ++ N+DD E D +S+ +S S+ + SS D S++P
Sbjct: 165 DSEAPDD--NSDDSEAPDD-------NSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVP 215
Query: 1095 EFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKL 1154
+ DKS + DD + V ++++ P + D+S +P S + +DD
Sbjct: 216 D--DKSDDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSE 273
Query: 1155 IFQEGKPVTE----KQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLE 1210
+ +E D+E D + + PE V D LE
Sbjct: 274 APDDSSDDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLE 333
Query: 1211 EGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKASPNVEAPQPH 1270
A +L E ++ +D V A++ +++ D S+ A + + E + P + P+ +
Sbjct: 334 VPVPAEDLCNEGQIASDEEELVEAAAA---VSQHDSSDDAGEQDLGENLSKPPSD-PEAN 389
Query: 1271 RHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIP 1307
V E E+ + +G+R+ T+ P
Sbjct: 390 PEVSERKLPTEEEPAPVVEQ--SGKRKSKTKTIVEPP 424
>gi|38261962 activating transcription factor 7 interacting protein
[Homo sapiens]
Length = 1270
Score = 47.0 bits (110), Expect = 3e-04
Identities = 54/268 (20%), Positives = 109/268 (40%), Gaps = 28/268 (10%)
Query: 962 RRDINVSVGSQQPDTKDSPVC---PHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEE 1018
+ D N+ + +T D+ +C P E I + + E A + ++ E
Sbjct: 340 KADNNIDANEETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNE 399
Query: 1019 MKAEQENQELPDEGTLEETLT-NETRNADDLEVSS--DIIEAVAISSNSFITTGKDSMTV 1075
+ + E +E +E+ + N N D +E I+E +A S + K S+
Sbjct: 400 DETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELTCFSKTSLLP 459
Query: 1076 SEVT---------ASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLP 1126
+ T +S SPS++++SE ++ +EED + G E +
Sbjct: 460 IDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEED-------ISGEKDESEVIS 512
Query: 1127 TELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASG 1186
Q+ + SPA E+ EK + ++++I ++ + +EK + + SK + + +
Sbjct: 513 ---QNETCSPAEVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKRSKSEDMDNVQSKR 569
Query: 1187 SSAMSPETTVS---QIAVESDLGQMLEE 1211
M E +I + D+ Q L++
Sbjct: 570 RRYMEEEYEAEFQVKITAKGDINQKLQK 597
Score = 32.0 bits (71), Expect = 9.0
Identities = 34/126 (26%), Positives = 58/126 (46%), Gaps = 19/126 (15%)
Query: 2006 EATLKTAVEHVCIFKLRENSKATDEDI---LAKGKQSIRSQALGNQNSENEILLEGDDDT 2062
E TL+T +C + EN K +EDI LA G+ +I S +Q +NE E D
Sbjct: 349 EETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNED--ETSADL 406
Query: 2063 LSSVDEKDLEN------LAGPVSLSTP-----AQLVAPSVVVKGTLSVTSSELYFEVDEE 2111
+ +++E +E+ L S+ T + +APS + L+ S +DE
Sbjct: 407 VETINENVIEDNKSENILENTDSMETDEIIPILEKLAPS---EDELTCFSKTSLLPIDET 463
Query: 2112 DPNFKK 2117
+P+ ++
Sbjct: 464 NPDLEE 469
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/260 (22%), Positives = 100/260 (38%), Gaps = 22/260 (8%)
Query: 990 NENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETL-TNETRNADDL 1048
NE+ + + ++SN+E NT EE++ E+ + EG EE + ET+ + L
Sbjct: 1272 NEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGL 1331
Query: 1049 EVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDD 1108
+ +E + T E + EE E L + V+ EE
Sbjct: 1332 QEEGVQLE-------------ETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVK 1378
Query: 1109 DYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTD 1168
+ E ++G EE L++ L S G++L + D QE PV E++
Sbjct: 1379 EGPEGGLQGEALEEG-----LKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAG 1433
Query: 1169 TETQDSKD---SGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLI 1225
+ ++ G + T S + + S+ S L LE+ AT + +E
Sbjct: 1434 RASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
Query: 1226 NDCHGSVSEASSEQKIAKLD 1245
G+ +SS A LD
Sbjct: 1494 QPTQGAAERSSSVACSAALD 1513
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 46.2 bits (108), Expect = 5e-04
Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 19/93 (20%)
Query: 2610 ILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLW 2669
I++ G D++ +V++ +TG I ++GH V C+ E ++SGSRDATL +W
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------RVVSGSRDATLRVW 368
Query: 2670 YWNGKCSGIGDNPGSETAAPRAILTGHDYEVTC 2702
ET +L GH V C
Sbjct: 369 -------------DIETGQCLHVLMGHVAAVRC 388
Score = 35.0 bits (79), Expect = 1.1
Identities = 21/92 (22%), Positives = 42/92 (45%), Gaps = 7/92 (7%)
Query: 2611 LVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLW- 2669
+V G D S RV+ +TG I + GH + + + ++ ++SG+ D+T+ +W
Sbjct: 436 VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN------ILVSGNADSTVKIWD 489
Query: 2670 YWNGKCSGIGDNPGSETAAPRAILTGHDYEVT 2701
G+C P +A + ++ +T
Sbjct: 490 IKTGQCLQTLQGPNKHQSAVTCLQFNKNFVIT 521
Score = 33.9 bits (76), Expect = 2.4
Identities = 19/63 (30%), Positives = 34/63 (53%), Gaps = 9/63 (14%)
Query: 2610 ILVCGFWDKSFRVYSTDTGRLIQVVFG---HWDVVTCLARSESYIGGNCYILSGSRDATL 2666
ILV G D + +++ TG+ +Q + G H VTCL +++ ++++ S D T+
Sbjct: 475 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN------FVITSSDDGTV 528
Query: 2667 LLW 2669
LW
Sbjct: 529 KLW 531
Score = 33.1 bits (74), Expect = 4.0
Identities = 33/127 (25%), Positives = 53/127 (41%), Gaps = 22/127 (17%)
Query: 2611 LVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWY 2670
+V G D + +V+S TG+ ++ + GH V ++ I+SGS D TL +W
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN------IIISGSTDRTLKVW- 328
Query: 2671 WNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSM-NGD 2729
+ET L GH V C + + V+SGS++ + + G
Sbjct: 329 ------------NAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQ 374
Query: 2730 LLRTLEG 2736
L L G
Sbjct: 375 CLHVLMG 381
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 46.2 bits (108), Expect = 5e-04
Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 19/93 (20%)
Query: 2610 ILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLW 2669
I++ G D++ +V++ +TG I ++GH V C+ E ++SGSRDATL +W
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------RVVSGSRDATLRVW 486
Query: 2670 YWNGKCSGIGDNPGSETAAPRAILTGHDYEVTC 2702
ET +L GH V C
Sbjct: 487 -------------DIETGQCLHVLMGHVAAVRC 506
Score = 35.0 bits (79), Expect = 1.1
Identities = 21/92 (22%), Positives = 42/92 (45%), Gaps = 7/92 (7%)
Query: 2611 LVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLW- 2669
+V G D S RV+ +TG I + GH + + + ++ ++SG+ D+T+ +W
Sbjct: 554 VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN------ILVSGNADSTVKIWD 607
Query: 2670 YWNGKCSGIGDNPGSETAAPRAILTGHDYEVT 2701
G+C P +A + ++ +T
Sbjct: 608 IKTGQCLQTLQGPNKHQSAVTCLQFNKNFVIT 639
Score = 33.9 bits (76), Expect = 2.4
Identities = 19/63 (30%), Positives = 34/63 (53%), Gaps = 9/63 (14%)
Query: 2610 ILVCGFWDKSFRVYSTDTGRLIQVVFG---HWDVVTCLARSESYIGGNCYILSGSRDATL 2666
ILV G D + +++ TG+ +Q + G H VTCL +++ ++++ S D T+
Sbjct: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN------FVITSSDDGTV 646
Query: 2667 LLW 2669
LW
Sbjct: 647 KLW 649
Score = 33.1 bits (74), Expect = 4.0
Identities = 33/127 (25%), Positives = 53/127 (41%), Gaps = 22/127 (17%)
Query: 2611 LVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWY 2670
+V G D + +V+S TG+ ++ + GH V ++ I+SGS D TL +W
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN------IIISGSTDRTLKVW- 446
Query: 2671 WNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSM-NGD 2729
+ET L GH V C + + V+SGS++ + + G
Sbjct: 447 ------------NAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQ 492
Query: 2730 LLRTLEG 2736
L L G
Sbjct: 493 CLHVLMG 499
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 46.2 bits (108), Expect = 5e-04
Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 19/93 (20%)
Query: 2610 ILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLW 2669
I++ G D++ +V++ +TG I ++GH V C+ E ++SGSRDATL +W
Sbjct: 353 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------RVVSGSRDATLRVW 406
Query: 2670 YWNGKCSGIGDNPGSETAAPRAILTGHDYEVTC 2702
ET +L GH V C
Sbjct: 407 -------------DIETGQCLHVLMGHVAAVRC 426
Score = 35.0 bits (79), Expect = 1.1
Identities = 21/92 (22%), Positives = 42/92 (45%), Gaps = 7/92 (7%)
Query: 2611 LVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLW- 2669
+V G D S RV+ +TG I + GH + + + ++ ++SG+ D+T+ +W
Sbjct: 474 VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN------ILVSGNADSTVKIWD 527
Query: 2670 YWNGKCSGIGDNPGSETAAPRAILTGHDYEVT 2701
G+C P +A + ++ +T
Sbjct: 528 IKTGQCLQTLQGPNKHQSAVTCLQFNKNFVIT 559
Score = 33.9 bits (76), Expect = 2.4
Identities = 19/63 (30%), Positives = 34/63 (53%), Gaps = 9/63 (14%)
Query: 2610 ILVCGFWDKSFRVYSTDTGRLIQVVFG---HWDVVTCLARSESYIGGNCYILSGSRDATL 2666
ILV G D + +++ TG+ +Q + G H VTCL +++ ++++ S D T+
Sbjct: 513 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN------FVITSSDDGTV 566
Query: 2667 LLW 2669
LW
Sbjct: 567 KLW 569
Score = 33.1 bits (74), Expect = 4.0
Identities = 33/127 (25%), Positives = 53/127 (41%), Gaps = 22/127 (17%)
Query: 2611 LVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWY 2670
+V G D + +V+S TG+ ++ + GH V ++ I+SGS D TL +W
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN------IIISGSTDRTLKVW- 366
Query: 2671 WNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSM-NGD 2729
+ET L GH V C + + V+SGS++ + + G
Sbjct: 367 ------------NAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQ 412
Query: 2730 LLRTLEG 2736
L L G
Sbjct: 413 CLHVLMG 419
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 46.2 bits (108), Expect = 5e-04
Identities = 25/64 (39%), Positives = 40/64 (62%), Gaps = 6/64 (9%)
Query: 2611 LVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLA--RSESYIGGNCYILSGSRDATLLL 2668
++ G +DK+ R++S + G+ I + GH DVV +A + +S +C +LS S D T+LL
Sbjct: 114 ILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSL---SCLLLSASMDQTILL 169
Query: 2669 WYWN 2672
W WN
Sbjct: 170 WEWN 173
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 45.8 bits (107), Expect = 6e-04
Identities = 76/363 (20%), Positives = 129/363 (35%), Gaps = 46/363 (12%)
Query: 981 VCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSY-EEMKAEQENQELPDEGTLEETLT 1039
V H E + + S E+ +E QT T EE+ E+E + +EG EE
Sbjct: 432 VSTHIKVKSEEKIKVVEKSEKETVI-VEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGE 490
Query: 1040 NETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDK 1099
E + E S E A + K+ ++ A SP +E+A E
Sbjct: 491 EEEAEGGEEETKSPPAEEAASPEKEAKSPVKEE---AKSPAEAKSPEKEEAKSPAEVKSP 547
Query: 1100 SIVEEEEDDDYVELKVEGSP-TEEANLPTEL----------QDNSLSPAASEAGEKLDMF 1148
+ ++ SP EEA P E+ ++ + SPA +++ EK
Sbjct: 548 EKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP 607
Query: 1149 GNDDKLIFQEGK-PVTE-----------KQTDTETQDSKDSGIQTMTASGSSAMSPETTV 1196
++ E K PV E ++ + T++ S + + A SPE
Sbjct: 608 VKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK 667
Query: 1197 SQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERL 1256
S + E+ + + KA E K V E + + AK V A E+
Sbjct: 668 SPVKAEAKSPEKAKSPVKA-----EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK- 721
Query: 1257 ELKASPNVEAPQPHRHVLEISRQHEQPGQG-----------IAPDAVNGQRRDSRSTVFR 1305
K+ EA P + + + + P + +P+A + ++RS +
Sbjct: 722 -AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK 780
Query: 1306 IPE 1308
PE
Sbjct: 781 FPE 783
Score = 33.9 bits (76), Expect = 2.4
Identities = 43/193 (22%), Positives = 73/193 (37%), Gaps = 11/193 (5%)
Query: 995 IEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDI 1054
I K ++S E + +E + E ++ P EE ++ A E
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873
Query: 1055 IE-----AVAISSNSFITTGKDSMTVSEV--TASISSPSEEDASEMPEFLDKSIVEEEED 1107
+E AV S + K+ + T +P++ + E + +K+ V ++E
Sbjct: 874 VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933
Query: 1108 DDYVELKVEGSPTEEANLPTELQDNSLSPAAS--EAGEKLDMFGNDDKLIFQE-GKPVTE 1164
DD + K P E+ E +D A E + DDK + +E KP E
Sbjct: 934 DD-AKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAE 992
Query: 1165 KQTDTETQDSKDS 1177
K + + D KDS
Sbjct: 993 KAEKSSSTDQKDS 1005
>gi|56243583 WD repeat domain 18 [Homo sapiens]
Length = 432
Score = 44.3 bits (103), Expect = 0.002
Identities = 30/117 (25%), Positives = 53/117 (45%), Gaps = 8/117 (6%)
Query: 2585 QITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCL 2644
Q D L Q I +T+ + V +S ++ TG L+ ++ H+ V+CL
Sbjct: 68 QRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCL 127
Query: 2645 ARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVT 2701
+ G + + +SG +D +L+W CS + +P S APR + + H +T
Sbjct: 128 ----QFTGDSSHFISGGKDCLVLVW---SLCSVLQADP-SRIPAPRHVWSHHALPIT 176
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 104,649,482
Number of Sequences: 37866
Number of extensions: 4641130
Number of successful extensions: 17225
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 275
Number of HSP's that attempted gapping in prelim test: 15676
Number of HSP's gapped (non-prelim): 1578
length of query: 2863
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2743
effective length of database: 13,703,598
effective search space: 37588969314
effective search space used: 37588969314
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.