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Search of human proteins with 146231998
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|146231998 G protein-coupled receptor kinase interactor 1
isoform 1 [Homo sapiens]
(770 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|146231998 G protein-coupled receptor kinase interactor 1 isof... 1540 0.0
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo... 1514 0.0
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP... 953 0.0
gi|206725422 G protein-coupled receptor kinase interacting ArfGA... 933 0.0
gi|206725420 G protein-coupled receptor kinase interacting ArfGA... 850 0.0
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP... 848 0.0
gi|206725415 G protein-coupled receptor kinase interacting ArfGA... 729 0.0
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP... 713 0.0
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 129 1e-29
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 126 9e-29
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 126 9e-29
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 124 3e-28
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 123 7e-28
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 123 7e-28
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 123 7e-28
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 122 1e-27
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 119 1e-26
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 118 2e-26
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 115 2e-25
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 107 3e-23
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 107 3e-23
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 86 2e-16
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 86 2e-16
gi|7661880 centaurin beta1 [Homo sapiens] 84 6e-16
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 81 3e-15
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 79 2e-14
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,... 79 2e-14
gi|187608516 centaurin, beta 2 [Homo sapiens] 77 8e-14
gi|46094081 development and differentiation enhancing factor 1 [... 71 3e-12
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 68 3e-11
>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
1 [Homo sapiens]
Length = 770
Score = 1540 bits (3986), Expect = 0.0
Identities = 770/770 (100%), Positives = 770/770 (100%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL
Sbjct: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL
Sbjct: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT
Sbjct: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRE 300
HKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRE
Sbjct: 241 HKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRE 300
Query: 301 NDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEA 360
NDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEA
Sbjct: 301 NDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEA 360
Query: 361 KRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 420
KRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM
Sbjct: 361 KRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 420
Query: 421 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 480
DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL
Sbjct: 421 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 480
Query: 481 RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRL 540
RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRL
Sbjct: 481 RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRL 540
Query: 541 QPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHG 600
QPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHG
Sbjct: 541 QPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHG 600
Query: 601 SGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQ 660
SGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQ
Sbjct: 601 SGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQ 660
Query: 661 VTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYR 720
VTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYR
Sbjct: 661 VTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYR 720
Query: 721 LQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ 770
LQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ
Sbjct: 721 LQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ 770
>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
2 [Homo sapiens]
Length = 761
Score = 1514 bits (3919), Expect = 0.0
Identities = 761/770 (98%), Positives = 761/770 (98%), Gaps = 9/770 (1%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL
Sbjct: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL
Sbjct: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT
Sbjct: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRE 300
HKNGHYIIPQMAD SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRE
Sbjct: 241 HKNGHYIIPQMAD---------SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRE 291
Query: 301 NDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEA 360
NDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEA
Sbjct: 292 NDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEA 351
Query: 361 KRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 420
KRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM
Sbjct: 352 KRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 411
Query: 421 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 480
DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL
Sbjct: 412 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 471
Query: 481 RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRL 540
RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRL
Sbjct: 472 RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRL 531
Query: 541 QPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHG 600
QPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHG
Sbjct: 532 QPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHG 591
Query: 601 SGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQ 660
SGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQ
Sbjct: 592 SGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQ 651
Query: 661 VTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYR 720
VTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYR
Sbjct: 652 VTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYR 711
Query: 721 LQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ 770
LQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ
Sbjct: 712 LQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ 761
>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 1 [Homo sapiens]
Length = 759
Score = 953 bits (2463), Expect = 0.0
Identities = 514/789 (65%), Positives = 604/789 (76%), Gaps = 55/789 (6%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRR 299
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRR
Sbjct: 241 HKNGQHFIIPQMAD--------SSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRR 292
Query: 300 ENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSE 359
E DAVWLATQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+
Sbjct: 293 ETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSD 352
Query: 360 AKRRQQGKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGAT 412
AKRRQQG SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+
Sbjct: 353 AKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTAS 408
Query: 413 RSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHK 472
++NR +S+D SDLSDG VT+QE++E+K AL SEAK+QQLMKVN++LSDELR +Q+++
Sbjct: 409 KTNRQKSLD-SDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQT 467
Query: 473 LQAENLQLRQPPG----PVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPF 528
LQ+EN LR+ V T ++ + H+ + S R + SMYE GS KP+
Sbjct: 468 LQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSA--RGSRPMSMYETGSGQKPY 525
Query: 529 GGPPG-----DELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLL 583
P G +E RLQPF PA + R S+S++P PS+ L
Sbjct: 526 -LPMGEASRPEESRMRLQPF---------------PAHIGRSALVTSSSSLPSFPST--L 567
Query: 584 SCSQ-EGSRHTSKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELE 638
S S+ E +R S+L + S +SDY+NT + G+ +G++ + + P+
Sbjct: 568 SWSRDESARRASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTA 627
Query: 639 SLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF 698
P LPSTEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LF
Sbjct: 628 EPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALF 687
Query: 699 PKRPALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAK 758
PK+P + VR+SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAK
Sbjct: 688 PKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAK 747
Query: 759 QLVTITTRE 767
QLVTITT+E
Sbjct: 748 QLVTITTKE 756
>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 5 [Homo sapiens]
Length = 729
Score = 933 bits (2412), Expect = 0.0
Identities = 504/788 (63%), Positives = 587/788 (74%), Gaps = 83/788 (10%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRR 299
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRR
Sbjct: 241 HKNGQHFIIPQMAD--------SSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRR 292
Query: 300 ENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSE 359
E DAVWLATQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+
Sbjct: 293 ETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSD 352
Query: 360 AKRRQQGKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGAT 412
AKRRQQG SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+
Sbjct: 353 AKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTAS 408
Query: 413 RSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHK 472
++NR +S+D SDLSDG VT+QE++E+K AL SEAK+QQLMKVN++LSDELR +Q+++
Sbjct: 409 KTNRQKSLD-SDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQT 467
Query: 473 LQAENLQLRQPPG----PVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPF 528
LQ+EN LR+ V T ++ + H+ + S R + SMYE GS KP+
Sbjct: 468 LQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSA--RGSRPMSMYETGSGQKPY 525
Query: 529 GGPPG-----DELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLL 583
P G +E RLQPF PA
Sbjct: 526 -LPMGEASRPEESRMRLQPF---------------PA----------------------- 546
Query: 584 SCSQEGSRHTSKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELES 639
H S+L + S +SDY+NT + G+ +G++ + + P+
Sbjct: 547 --------HASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAE 598
Query: 640 LDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFP 699
P LPSTEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFP
Sbjct: 599 PHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFP 658
Query: 700 KRPALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQ 759
K+P + VR+SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQ
Sbjct: 659 KKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQ 718
Query: 760 LVTITTRE 767
LVTITT+E
Sbjct: 719 LVTITTKE 726
>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 6 [Homo sapiens]
Length = 681
Score = 850 bits (2195), Expect = 0.0
Identities = 472/784 (60%), Positives = 544/784 (69%), Gaps = 123/784 (15%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRR 299
HKNG H+IIPQMADR SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRR
Sbjct: 241 HKNGQHFIIPQMADR------RLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRR 294
Query: 300 ENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSE 359
E DAVWLATQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+
Sbjct: 295 ETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSD 354
Query: 360 AKRRQQGKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGAT 412
AKRRQQG SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+
Sbjct: 355 AKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTAS 410
Query: 413 RSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHK 472
++NR K+Q L NS+L ++ +++
Sbjct: 411 KTNR------------------------------QKLQTLQSENSNLR---KQATTNVYQ 437
Query: 473 LQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPP 532
+Q G T + P A G + SMYE GS KP+ P
Sbjct: 438 VQT---------GSEYTDTSNHSSLKRRPSARGS-------RPMSMYETGSGQKPY-LPM 480
Query: 533 G-----DELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQ 587
G +E RLQPF PA
Sbjct: 481 GEASRPEESRMRLQPF---------------PA--------------------------- 498
Query: 588 EGSRHTSKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGD 643
H S+L + S +SDY+NT + G+ +G++ + + P+
Sbjct: 499 ----HASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVA 554
Query: 644 LDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPA 703
P LPSTEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P
Sbjct: 555 PSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPK 614
Query: 704 LEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTI 763
+ VR+SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTI
Sbjct: 615 SDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTI 674
Query: 764 TTRE 767
TT+E
Sbjct: 675 TTKE 678
>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 3 [Homo sapiens]
Length = 679
Score = 848 bits (2191), Expect = 0.0
Identities = 471/784 (60%), Positives = 543/784 (69%), Gaps = 125/784 (15%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRR 299
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRR
Sbjct: 241 HKNGQHFIIPQMAD--------SSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRR 292
Query: 300 ENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSE 359
E DAVWLATQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+
Sbjct: 293 ETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSD 352
Query: 360 AKRRQQGKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGAT 412
AKRRQQG SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+
Sbjct: 353 AKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTAS 408
Query: 413 RSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHK 472
++NR K+Q L NS+L ++ +++
Sbjct: 409 KTNR------------------------------QKLQTLQSENSNLR---KQATTNVYQ 435
Query: 473 LQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPP 532
+Q G T + P A G + SMYE GS KP+ P
Sbjct: 436 VQT---------GSEYTDTSNHSSLKRRPSARGS-------RPMSMYETGSGQKPY-LPM 478
Query: 533 G-----DELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQ 587
G +E RLQPF PA
Sbjct: 479 GEASRPEESRMRLQPF---------------PA--------------------------- 496
Query: 588 EGSRHTSKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGD 643
H S+L + S +SDY+NT + G+ +G++ + + P+
Sbjct: 497 ----HASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVA 552
Query: 644 LDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPA 703
P LPSTEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P
Sbjct: 553 PSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPK 612
Query: 704 LEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTI 763
+ VR+SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTI
Sbjct: 613 SDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTI 672
Query: 764 TTRE 767
TT+E
Sbjct: 673 TTKE 676
>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 4 [Homo sapiens]
Length = 471
Score = 729 bits (1882), Expect = 0.0
Identities = 367/478 (76%), Positives = 412/478 (86%), Gaps = 21/478 (4%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRR 299
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRR
Sbjct: 241 HKNGQHFIIPQMAD--------SSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRR 292
Query: 300 ENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSE 359
E DAVWLATQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+
Sbjct: 293 ETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSD 352
Query: 360 AKRRQQGKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGAT 412
AKRRQQG SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+
Sbjct: 353 AKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTAS 408
Query: 413 RSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREI 470
++NR +S+D SDLSDG VT+QE++E+K AL SEAK+QQLMKVN++LSDELR +Q+++
Sbjct: 409 KTNRQKSLD-SDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKL 465
>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 2 [Homo sapiens]
Length = 631
Score = 713 bits (1840), Expect = 0.0
Identities = 374/542 (69%), Positives = 420/542 (77%), Gaps = 51/542 (9%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRR 299
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRR
Sbjct: 241 HKNGQHFIIPQMAD--------SSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRR 292
Query: 300 ENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSE 359
E DAVWLATQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+
Sbjct: 293 ETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSD 352
Query: 360 AKRRQQGKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGAT 412
AKRRQQG SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+
Sbjct: 353 AKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTAS 408
Query: 413 RSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHK 472
++NR +S+D SDLSDG VT+QE++E+K AL SEAK+QQLMK + +
Sbjct: 409 KTNRQKSLD-SDLSDGPVTVQEFMEVKNALVASEAKIQQLMKAS---------------R 452
Query: 473 LQAENLQLRQPPGPVPTPPLPSERAEHTP--MAPGGSTHRRDRQAFSMYEPGSALKPFGG 530
L+ +N P ++TP M P G R + SM PG L P
Sbjct: 453 LEKQN-------------STPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTA 499
Query: 531 PP 532
P
Sbjct: 500 EP 501
Score = 204 bits (520), Expect = 2e-52
Identities = 107/178 (60%), Positives = 135/178 (75%), Gaps = 4/178 (2%)
Query: 594 SKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGDLDPGLP 649
S+L + S +SDY+NT + G+ +G++ + + P+ P LP
Sbjct: 451 SRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLP 510
Query: 650 STEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRS 709
STEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P + VR+
Sbjct: 511 STEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRT 570
Query: 710 SLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTRE 767
SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTITT+E
Sbjct: 571 SLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKE 628
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 129 bits (324), Expect = 1e-29
Identities = 77/214 (35%), Positives = 112/214 (52%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC AP+P WAS++ G L+C EC +HR LG H+S V+ L WPP LL ++ + +
Sbjct: 677 CIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNA 736
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANS+WE +L G K P D K +IRAKY+ F+ LP D
Sbjct: 737 LANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPSSD------ 782
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGTTPLHVAAKAGQTLQAELLV 187
L +QL +V +L + LL+ G++ + G T LH+++ + +LL+
Sbjct: 783 VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLI 842
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D S D G TP+ YAR+AG E A+ L++
Sbjct: 843 WYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 126 bits (316), Expect = 9e-29
Identities = 73/214 (34%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ G L+C EC +HR+LG H+S V+ L WP L++++ ++ +
Sbjct: 571 CVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNE 630
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANS+WE S GR K + D K +IRAKY+ F+ LPC T
Sbjct: 631 LANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC------TE 676
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L + L + +L T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 677 LSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLI 736
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E + L++
Sbjct: 737 WYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 770
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 126 bits (316), Expect = 9e-29
Identities = 73/214 (34%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ G L+C EC +HR+LG H+S V+ L WP L++++ ++ +
Sbjct: 624 CVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNE 683
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANS+WE S GR K + D K +IRAKY+ F+ LPC T
Sbjct: 684 LANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC------TE 729
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L + L + +L T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 730 LSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLI 789
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E + L++
Sbjct: 790 WYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 124 bits (311), Expect = 3e-28
Identities = 76/214 (35%), Positives = 115/214 (53%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRSLG H+S V+ L WP L +++ ++ ++
Sbjct: 479 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVND 538
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 539 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 584
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G+ + N E G T LH+A + G + A+LL+
Sbjct: 585 LSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLI 644
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E L++
Sbjct: 645 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 123 bits (308), Expect = 7e-28
Identities = 73/215 (33%), Positives = 115/215 (53%), Gaps = 17/215 (7%)
Query: 10 VCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLAS 69
+C DC AP+P WAS++ G L+C EC +HR+LG H+S V+ L WP L ++ + +
Sbjct: 945 ICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGN 1004
Query: 70 NGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVT 129
+ AN +WE GR K + +D + +IRAKY+ L F+ L +
Sbjct: 1005 DTANRVWESD-------TRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL------STS 1050
Query: 130 AKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGTTPLHVAAKAGQTLQAELL 186
+ L +QL ++V+ ++ T L LL+ G + +PLH+AA+ + +LL
Sbjct: 1051 EEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLL 1110
Query: 187 VVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
+ YGAD + D GRT + YARQAG A+ L++
Sbjct: 1111 LWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 123 bits (308), Expect = 7e-28
Identities = 73/215 (33%), Positives = 115/215 (53%), Gaps = 17/215 (7%)
Query: 10 VCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLAS 69
+C DC AP+P WAS++ G L+C EC +HR+LG H+S V+ L WP L ++ + +
Sbjct: 589 ICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGN 648
Query: 70 NGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVT 129
+ AN +WE GR K + +D + +IRAKY+ L F+ L +
Sbjct: 649 DTANRVWESD-------TRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL------STS 694
Query: 130 AKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGTTPLHVAAKAGQTLQAELL 186
+ L +QL ++V+ ++ T L LL+ G + +PLH+AA+ + +LL
Sbjct: 695 EEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLL 754
Query: 187 VVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
+ YGAD + D GRT + YARQAG A+ L++
Sbjct: 755 LWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 123 bits (308), Expect = 7e-28
Identities = 74/214 (34%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRSLG +S V+ L WP L +++ ++ ++
Sbjct: 456 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 515
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S GR K + K +IR+KY+ F+ LPC T
Sbjct: 516 LANSIWEGS-------SQGRTKPT-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 561
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 562 LSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 621
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E L++
Sbjct: 622 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 122 bits (306), Expect = 1e-27
Identities = 76/222 (34%), Positives = 115/222 (51%), Gaps = 19/222 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRSLG +S V+ L WP L +++ ++ ++
Sbjct: 456 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 515
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 516 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 561
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 562 LSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 621
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDR 229
YG D + D +G T + YARQA E L+ QY D+
Sbjct: 622 WYGVDVMARDAHGNTALTYARQASSQECINVLL--QYGCPDK 661
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 119 bits (298), Expect = 1e-26
Identities = 72/214 (33%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +H SLG +S V+ L WP L +++ ++ ++
Sbjct: 456 CVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGND 515
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 516 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 561
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 562 LSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 621
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E L++
Sbjct: 622 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 118 bits (296), Expect = 2e-26
Identities = 72/214 (33%), Positives = 110/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRSLG +S V+ L WP L +++ ++ ++
Sbjct: 343 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 402
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 403 LANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC------TE 448
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L + L + +L T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 449 LSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 508
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E L++
Sbjct: 509 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 115 bits (287), Expect = 2e-25
Identities = 71/214 (33%), Positives = 110/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C D +P WAS++ GVL+C EC +HRSLG +S V+ L WP L +++ ++ ++
Sbjct: 479 CVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 538
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 539 LANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC------TE 584
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L + L + +L+T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 585 LSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 644
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E L++
Sbjct: 645 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 107 bits (268), Expect = 3e-23
Identities = 70/214 (32%), Positives = 107/214 (50%), Gaps = 19/214 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRS G +S V+ L WP L +++ ++ +
Sbjct: 479 CVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNE 538
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 539 LANSIWEGS-------SQGQTKPSIK-STREEKEWWIRSKYEEKLFLAPLPC------TE 584
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G++ G T LH+A + G + +LL
Sbjct: 585 LSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL- 643
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
G D + D +G T + YARQA E L++
Sbjct: 644 -XGVDVMARDAHGNTALTYARQASSQECINVLLQ 676
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 107 bits (268), Expect = 3e-23
Identities = 70/214 (32%), Positives = 107/214 (50%), Gaps = 19/214 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRS G +S V+ L WP L +++ ++ +
Sbjct: 479 CVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNE 538
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 539 LANSIWEGS-------SQGQTKPSIK-STREEKEWWIRSKYEEKLFLAPLPC------TE 584
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G++ G T LH+A + G + +LL
Sbjct: 585 LSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL- 643
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
G D + D +G T + YARQA E L++
Sbjct: 644 -XGVDVMARDAHGNTALTYARQASSQECINVLLQ 676
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 85.5 bits (210), Expect = 2e-16
Identities = 57/179 (31%), Positives = 88/179 (49%), Gaps = 15/179 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLR--HSAWPPTLLQMVHTLA 68
CADC AP P WASI+ V++C C HR LG +S V+ L+ W TL+++ L
Sbjct: 305 CADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLG 364
Query: 69 SNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGV 128
+ N W ++ +Q ++P + +++++ KY+ H L +
Sbjct: 365 NGAGNRFWAANVPPSEALQP---SSSPSTRRCHLEAKYREGKYRR---YHPLFGNQE--- 415
Query: 129 TAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPE-KGTTPLHVAAKAGQTLQAELL 186
+L K L ++V T +L LL GA N F + + TPL +A +AGQTLQ E L
Sbjct: 416 ---ELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFL 471
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 85.5 bits (210), Expect = 2e-16
Identities = 57/179 (31%), Positives = 88/179 (49%), Gaps = 15/179 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLR--HSAWPPTLLQMVHTLA 68
CADC AP P WASI+ V++C C HR LG +S V+ L+ W TL+++ L
Sbjct: 550 CADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLG 609
Query: 69 SNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGV 128
+ N W ++ +Q ++P + +++++ KY+ H L +
Sbjct: 610 NGAGNRFWAANVPPSEALQP---SSSPSTRRCHLEAKYREGKYRR---YHPLFGNQE--- 660
Query: 129 TAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPE-KGTTPLHVAAKAGQTLQAELL 186
+L K L ++V T +L LL GA N F + + TPL +A +AGQTLQ E L
Sbjct: 661 ---ELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFL 716
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 83.6 bits (205), Expect = 6e-16
Identities = 72/244 (29%), Positives = 101/244 (41%), Gaps = 45/244 (18%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC P P WASI+ GV +C +C +HRSLG H S V+ L +W P L++++ L +
Sbjct: 420 CCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNV 479
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLP--------- 121
N I+E A+V++ K K +I AKY F+ KLP
Sbjct: 480 IINQIYE------ARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGR 533
Query: 122 ---------------------CRDDDGVTAKDLSKQLH-------SSVRTGNLETCLRLL 153
R ++DL LH +S +L T L
Sbjct: 534 GRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLG-SLHPGALLFRASGHPPSLPTMADAL 592
Query: 154 SLGAQANFFH-PEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGH 212
+ GA N+ + + TPL A A L E L+ GA+ D GR P+ +A GH
Sbjct: 593 AHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGH 652
Query: 213 HELA 216
LA
Sbjct: 653 TGLA 656
Score = 37.0 bits (84), Expect = 0.069
Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 1/89 (1%)
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYG 190
+D + L + +L C LL GA N G PLH A G T A L + G
Sbjct: 605 QDNATPLIQATAANSLLACEFLLQNGANVNQAD-SAGRGPLHHATILGHTGLACLFLKRG 663
Query: 191 ADPGSPDVNGRTPIDYARQAGHHELAERL 219
AD G+ D GR P+ A + + ++ L
Sbjct: 664 ADLGARDSEGRDPLTIAMETANADIVTLL 692
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 81.3 bits (199), Expect = 3e-15
Identities = 40/101 (39%), Positives = 60/101 (59%), Gaps = 1/101 (0%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC PDP WASI+ GVL+C EC +HRSLG H S V+ L +W P LL+++ L ++
Sbjct: 418 CGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNS 477
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKY 111
N I+E + + A + ++ QDK IK +++ K+
Sbjct: 478 AVNQIYE-AQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKF 517
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/75 (33%), Positives = 35/75 (46%), Gaps = 1/75 (1%)
Query: 138 HSSVRTGNLETCLRLLSLGAQANFFHPE-KGTTPLHVAAKAGQTLQAELLVVYGADPGSP 196
H + R +L L+ GA+ N+ E +G TPL A G + E L+ GAD
Sbjct: 673 HRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQR 732
Query: 197 DVNGRTPIDYARQAG 211
D GR P+ +A G
Sbjct: 733 DSRGRAPLHHATLLG 747
Score = 39.3 bits (90), Expect = 0.014
Identities = 32/96 (33%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 124 DDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQA 183
+D+G T L +V G+L C LL GA N +G PLH A G+T Q
Sbjct: 700 EDEGKTP------LVQAVLGGSLIVCEFLLQNGADVNQ-RDSRGRAPLHHATLLGRTGQV 752
Query: 184 ELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERL 219
L + GAD + D R P+ A QA + ++ L
Sbjct: 753 CLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLL 788
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
2 [Homo sapiens]
Length = 1704
Score = 79.0 bits (193), Expect = 2e-14
Identities = 59/179 (32%), Positives = 88/179 (49%), Gaps = 15/179 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSA--WPPTLLQMVHTLA 68
CADC APDP WASI+ V++C +C HRSLG S V+ L+ A W L+++ +
Sbjct: 700 CADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIG 759
Query: 69 SNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGV 128
+ AN W +L Q +P +K + FI KY+ F L +
Sbjct: 760 NKRANDFWAGNL----QKDEELHMDSPVEK----RKNFITQKYKEGKFRKTLLA----SL 807
Query: 129 TAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEK-GTTPLHVAAKAGQTLQAELL 186
T ++L+K L ++V ++ + LL GA + +TP +A KAGQ+LQ E L
Sbjct: 808 TKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFL 866
>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
member 1 [Homo sapiens]
Length = 284
Score = 78.6 bits (192), Expect = 2e-14
Identities = 55/180 (30%), Positives = 88/180 (48%), Gaps = 19/180 (10%)
Query: 46 SIVKHLRHSAWPPTLLQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDK-VHPIKS 104
S V+ L WP L +++ ++ ++ ANSIWE S + + P +K K
Sbjct: 112 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS---------SQGQTKPSEKSTREEKE 162
Query: 105 EFIRAKYQMLAFVHKLPCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHP 164
+IR+KY+ F+ LPC D L +QL + +L+T + LL+ G++
Sbjct: 163 RWIRSKYEEKLFLAPLPCTD------LSLGQQLLRATADEDLQTAILLLAHGSREEVNET 216
Query: 165 ---EKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
G T LH+A + G + A+LL+ YG D + D +G T + YARQA E L++
Sbjct: 217 CGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 276
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 76.6 bits (187), Expect = 8e-14
Identities = 41/109 (37%), Positives = 59/109 (54%), Gaps = 7/109 (6%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC DP WASI+ G+ +C EC +HRSLG H S V+ L W P LL+++ L ++
Sbjct: 414 CCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGND 473
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHK 119
N ++E ++ + G +K P + K +IRAKY FV K
Sbjct: 474 VINRVYEANV-----EKMGIKKPQPGQRQE--KEAYIRAKYVERKFVDK 515
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 136 QLHSSVRTGNLETCLRLLSLGAQANFFHPEKG-TTPLHVAAKAGQTLQAELLVVYGADPG 194
QL+ + NL L+ GA N+ + E+ TPL A G + E L+ GA+
Sbjct: 609 QLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVN 668
Query: 195 SPDVNGRTPIDYARQAGH 212
DV GR P+ +A GH
Sbjct: 669 QRDVQGRGPLHHATVLGH 686
Score = 40.0 bits (92), Expect = 0.008
Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 3/99 (3%)
Query: 137 LHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSP 196
L +V G+L TC LL GA N +G PLH A G T Q L + GA+ +
Sbjct: 645 LIQAVLGGSLVTCEFLLQNGANVNQ-RDVQGRGPLHHATVLGHTGQVCLFLKRGANQHAT 703
Query: 197 DVNGRTPIDYARQAGHHELAE--RLVECQYELTDRLAFY 233
D G+ P+ A +A + ++ RL E+ + Y
Sbjct: 704 DEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLY 742
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 71.2 bits (173), Expect = 3e-12
Identities = 116/536 (21%), Positives = 201/536 (37%), Gaps = 81/536 (15%)
Query: 6 PRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVH 65
P ++C DC + +P W S + G+L C EC +HR +G HIS ++ L + L +
Sbjct: 449 PGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAK 508
Query: 66 TLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDD 125
+ +N N I E +L P+ K P + ++ E+I AKY F K C
Sbjct: 509 NVGNNSFNDIMEANLPSPSP------KPTPSSDM-TVRKEYITAKYVDHRFSRK-TCS-- 558
Query: 126 DGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQ--ANFFHP--EKGTTPLHVAAKAGQTL 181
T+ +L ++++ +L +++ + G + P E G T LH+A +
Sbjct: 559 ---TSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQT 615
Query: 182 QAELLVVYGADPGSPDVN---GRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRK 238
L+ + G+ D G T + Y E + L+ K
Sbjct: 616 SLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR---------------SK 660
Query: 239 PDHKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDV-YDEVD 297
P + D +++ +Q DL AK+ K + + E ++ +E+D
Sbjct: 661 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGK-----FNPHVHVEYEWNLRQEEID 715
Query: 298 RRENDAVWLATQNHSTLVTERSAVP--------FLPVN----PEYSATRNQGRQKLARFN 345
++D S + ERS P P + P +S R++ R F
Sbjct: 716 ESDDD----LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFT 771
Query: 346 AREFATLIIDI----LSEA---KRRQQGKSLSSPTDNLELSLRS---QSDLDDQHDYDSV 395
+ F + D +EA R GK + P L LS ++ S L +
Sbjct: 772 NQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPP 831
Query: 396 ASDEDTDQEPLRSTGATRSNRARSMDSSD--LSDGAVTLQEYLELKKALATSEAKV---- 449
+ T +P N+ +D S + T ++ L + +TS AK
Sbjct: 832 PGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGP 891
Query: 450 --------QQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERA 497
+ ++ LS + + EI + ++ +L Q P P PP P+E A
Sbjct: 892 RVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELA 947
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 68.2 bits (165), Expect = 3e-11
Identities = 90/362 (24%), Positives = 142/362 (39%), Gaps = 68/362 (18%)
Query: 9 EVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLA 68
+VC DC APDP W S + G+L C EC +HR LG H S ++ L + L + +
Sbjct: 434 DVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIG 493
Query: 69 SNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHK--------- 119
+ G N I E L PA+ K NP ++ + ++I AKY + K
Sbjct: 494 NAGFNEIMECCL--PAE---DSVKPNPGSDMN-ARKDYITAKYIERRYARKKHADNAAKL 547
Query: 120 ------LPCRDDDGV-----TAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH----- 163
+ RD G+ DL++++ + ET L L H
Sbjct: 548 HSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFL 607
Query: 164 ----------PEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHH 213
KG+T LH +LL+ A + +G TP+D A++ H
Sbjct: 608 VQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHE 667
Query: 214 ELAERLVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADRSRQKCMSQSLDLSELAKAA 273
E L + L GR H + Y + + + LD S+
Sbjct: 668 HCEELLTQA-----------LSGRFNSHVHVEY---------EWRLLHEDLDESD--DDM 705
Query: 274 KKKLQALSNRLFEELAMDVYD-EVDRRENDAVWLATQNHSTLVTE--RSAVPFLPVNPEY 330
+KLQ NR E+ + Y ++ +++AV LA ++ + L E R+ +P + N Y
Sbjct: 706 DEKLQPSPNRR-EDRPISFYQLGSNQLQSNAVSLA-RDAANLAKEKQRAFMPSILQNETY 763
Query: 331 SA 332
A
Sbjct: 764 GA 765
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,889,000
Number of Sequences: 37866
Number of extensions: 1592241
Number of successful extensions: 10588
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 318
Number of HSP's successfully gapped in prelim test: 194
Number of HSP's that attempted gapping in prelim test: 8533
Number of HSP's gapped (non-prelim): 1928
length of query: 770
length of database: 18,247,518
effective HSP length: 110
effective length of query: 660
effective length of database: 14,082,258
effective search space: 9294290280
effective search space used: 9294290280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.