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Search of human proteins with 14589900
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
(334 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi... 673 0.0
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 537 e-153
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 530 e-151
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 374 e-104
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens] 355 4e-98
gi|239751247 PREDICTED: similar to mitogen-activated protein kin... 280 2e-75
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi... 266 1e-71
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ... 220 2e-57
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 218 8e-57
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi... 207 8e-54
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [... 207 8e-54
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 156 3e-38
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 155 4e-38
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 141 9e-34
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 140 2e-33
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 140 2e-33
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 140 2e-33
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 140 2e-33
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 140 2e-33
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 140 2e-33
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 140 2e-33
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 140 2e-33
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 139 5e-33
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 139 5e-33
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 139 5e-33
gi|145275208 myosin IIIA [Homo sapiens] 134 1e-31
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 132 3e-31
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 132 3e-31
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 132 3e-31
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 132 3e-31
>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
Length = 334
Score = 673 bits (1736), Expect = 0.0
Identities = 334/334 (100%), Positives = 334/334 (100%)
Query: 1 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG 60
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG
Sbjct: 1 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG 60
Query: 61 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF 120
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
Sbjct: 61 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF 120
Query: 121 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
Sbjct: 121 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180
Query: 181 KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI 240
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
Sbjct: 181 KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI 240
Query: 241 WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
Sbjct: 241 WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300
Query: 301 ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334
ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
Sbjct: 301 ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 537 bits (1384), Expect = e-153
Identities = 268/335 (80%), Positives = 301/335 (89%), Gaps = 2/335 (0%)
Query: 1 MSQSKGK-KRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMEL 59
M QSKGK KR L+I + + P + TPPR+LDS+ I+IG++NFEV+ADDL I EL
Sbjct: 12 MPQSKGKSKRKKDLRISCMS-KPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISEL 70
Query: 60 GRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL 119
GRGAYGVVEK+RH SG IMAVKRIRATVNSQEQKRLLMDLDI+MRTVDC +TVTFYGAL
Sbjct: 71 GRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGAL 130
Query: 120 FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRD 179
FREGDVWICMELMDTSLDKFY++V+DK TIPEDILG+IAVSIV+ALEHLHSKLSVIHRD
Sbjct: 131 FREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRD 190
Query: 180 VKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSD 239
VKPSNVLIN G VKMCDFGISGYLVDSVAKT+DAGCKPYMAPERINPELNQKGY+VKSD
Sbjct: 191 VKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSD 250
Query: 240 IWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNS 299
+WSLGITMIE+AILRFPY+SWGTPFQQLKQVVEEPSPQLPAD+FS EFVDFT+QCL+KN
Sbjct: 251 VWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNP 310
Query: 300 KERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334
ER +Y ELM+HPFFTLH++K TD+A+FVK ILG+
Sbjct: 311 AERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGE 345
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 530 bits (1366), Expect = e-151
Identities = 258/312 (82%), Positives = 288/312 (92%)
Query: 23 PQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVK 82
P + TPPR+LDS+ I+IG++NFEV+ADDL I ELGRGAYGVVEK+RH SG IMAVK
Sbjct: 5 PAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVK 64
Query: 83 RIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQ 142
RIRATVNSQEQKRLLMDLDI+MRTVDC +TVTFYGALFREGDVWICMELMDTSLDKFY++
Sbjct: 65 RIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRK 124
Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202
V+DK TIPEDILG+IAVSIV+ALEHLHSKLSVIHRDVKPSNVLIN G VKMCDFGISG
Sbjct: 125 VLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISG 184
Query: 203 YLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT 262
YLVDSVAKT+DAGCKPYMAPERINPELNQKGY+VKSD+WSLGITMIE+AILRFPY+SWGT
Sbjct: 185 YLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGT 244
Query: 263 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322
PFQQLKQVVEEPSPQLPAD+FS EFVDFT+QCL+KN ER +Y ELM+HPFFTLH++K T
Sbjct: 245 PFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKT 304
Query: 323 DVASFVKLILGD 334
D+A+FVK ILG+
Sbjct: 305 DIAAFVKEILGE 316
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 374 bits (961), Expect = e-104
Identities = 191/247 (77%), Positives = 212/247 (85%), Gaps = 1/247 (0%)
Query: 8 KRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVV 67
KR L+I + + P + T PR+LDS+ I+IG+ NFEV+ADDL I ELGRGAYGVV
Sbjct: 25 KRKKDLRISCMS-KPPAPNPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYGVV 83
Query: 68 EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWI 127
EK+RH SG IMAVK I ATVNS EQKRLLMDLDI+MRTVDC +TVTFYGALFREGDVWI
Sbjct: 84 EKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWI 143
Query: 128 CMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI 187
CMELMDTSLDKFY++V+DK TIPEDILG+IAVSIV+ALEHLHSKLSVIHRDVKPSNVLI
Sbjct: 144 CMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLI 203
Query: 188 NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 247
N G VKMCDFGISGYLVDSVAK +DAGCKPYMAPERINPELNQKGY+VKSD+WSLGITM
Sbjct: 204 NKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITM 263
Query: 248 IELAILR 254
+LR
Sbjct: 264 GRALLLR 270
>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
Length = 399
Score = 355 bits (910), Expect = 4e-98
Identities = 174/317 (54%), Positives = 226/317 (71%), Gaps = 5/317 (1%)
Query: 21 EQPQTSSTPPRDLDSKACISIG-NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIM 79
+ P ++S + I Q+++ A+DL+ + E+GRGAYG V KM H PSGQIM
Sbjct: 69 QNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIM 128
Query: 80 AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKF 139
AVKRIR+TV+ +EQK+LLMDLD+ MR+ DCP+ V FYGALFREGD WICMELM TS DKF
Sbjct: 129 AVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKF 188
Query: 140 YKQVIDK-GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198
YK V IPE+ILGKI ++ VKAL HL L +IHRD+KPSN+L++ G +K+CDF
Sbjct: 189 YKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDF 248
Query: 199 GISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD 258
GISG LVDS+AKT DAGC+PYMAPERI+P +++GY V+SD+WSLGIT+ ELA RFPY
Sbjct: 249 GISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP 308
Query: 259 SWGTPFQQLKQVVEEPSPQLPAD---KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315
W + F QL QVV+ PQL +FS F++F + CL K+ +RP Y EL++HPF
Sbjct: 309 KWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFIL 368
Query: 316 LHESKGTDVASFVKLIL 332
++E + +VA +V IL
Sbjct: 369 MYEERAVEVACYVCKIL 385
>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
kinase 3 [Homo sapiens]
Length = 198
Score = 280 bits (715), Expect = 2e-75
Identities = 134/150 (89%), Positives = 144/150 (96%)
Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157
MDLDI+MRTVDC +TVTFYGALFREGDVWICMELMDTSLDKFY++V+DK TIPEDILG+
Sbjct: 1 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK 217
IAVSIV+ALEHLHSKLSVIHRDVKPSNVLIN G VKMCDFGISGYLVDSVAKT+DAGCK
Sbjct: 61 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITM 247
PYMAPERINPELNQKGY+VKSD+WSLGITM
Sbjct: 121 PYMAPERINPELNQKGYNVKSDVWSLGITM 150
>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
Length = 419
Score = 266 bits (681), Expect = 1e-71
Identities = 137/296 (46%), Positives = 199/296 (67%), Gaps = 5/296 (1%)
Query: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM 98
++IG Q ++ + +DLE + E+G G G V KMR +G ++AVK++R + N +E KR+LM
Sbjct: 106 LTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILM 165
Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158
DLD+ +++ DCP+ V +G DV+I MELM T +K K++ IPE ILGK+
Sbjct: 166 DLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP---IPERILGKM 222
Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218
V+IVKAL +L K VIHRDVKPSN+L++ GQ+K+CDFGISG LVDS AKT AGC
Sbjct: 223 TVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAA 282
Query: 219 YMAPERIN-PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277
YMAPERI+ P+ + Y +++D+WSLGI+++ELA +FPY + T F+ L +V++E P
Sbjct: 283 YMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPL 342
Query: 278 LPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLIL 332
LP FS +F F CL K+ ++RP Y +L++H F +E+ DVAS+ K ++
Sbjct: 343 LPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVM 398
>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
Length = 448
Score = 220 bits (560), Expect = 2e-57
Identities = 139/334 (41%), Positives = 192/334 (57%), Gaps = 28/334 (8%)
Query: 6 GKKRNPGLKIPKEA----FEQPQTSSTPPRDLDSKACISIGN--QNFEVKADDLEPIMEL 59
G++ GLK+ A P S + P + K+ + N ++ D+ L
Sbjct: 113 GERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTL 172
Query: 60 GRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL 119
G G G V K HVPSG+I+AVK I + + QK+++ +L+I + D + + FYGA
Sbjct: 173 GHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAF 231
Query: 120 FREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178
F E + IC E MD SLD + K +PE +LG+IAV++VK L +L S L ++HR
Sbjct: 232 FVENRISICTEFMDGGSLDVYRK--------MPEHVLGRIAVAVVKGLTYLWS-LKILHR 282
Query: 179 DVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKS 238
DVKPSN+L+N GQVK+CDFG+S LV+S+AKT G YMAPERI+ E Y + S
Sbjct: 283 DVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISGE----QYGIHS 337
Query: 239 DIWSLGITMIELAILRFPY----DSWGT--PFQQLKQVVEEPSPQLPADKFSAEFVDFTS 292
D+WSLGI+ +ELA+ RFPY + G+ P Q L+ +V+E SP LP +FS FV F +
Sbjct: 338 DVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFIT 397
Query: 293 QCLKKNSKERPTYPELMQHPFFTLHESKGTDVAS 326
QC++K KERP ELM HPF V S
Sbjct: 398 QCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVS 431
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 218 bits (554), Expect = 8e-57
Identities = 125/329 (37%), Positives = 187/329 (56%), Gaps = 52/329 (15%)
Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106
E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + +
Sbjct: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 120
Query: 107 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165
+ P+ V FYGA + +G++ ICME MD SLD QV+ K IPE ILGK++++++K
Sbjct: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKKAGRIPEQILGKVSIAVIKG 176
Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225
L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER
Sbjct: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER- 234
Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPY------------------DSWGTP---- 263
L YSV+SDIWS+G++++E+A+ R+P D+ TP
Sbjct: 235 ---LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291
Query: 264 -------------------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 304
F+ L +V EP P+LP+ FS EF DF ++CL KN ER
Sbjct: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351
Query: 305 YPELMQHPFFTLHESKGTDVASFVKLILG 333
+LM H F +++ D A ++ +G
Sbjct: 352 LKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380
>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
Length = 400
Score = 207 bits (528), Expect = 8e-54
Identities = 121/328 (36%), Positives = 183/328 (55%), Gaps = 56/328 (17%)
Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106
E+K DD E I ELG G GVV K++H PSG IMA K I + + +++ +L + +
Sbjct: 66 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV-LHE 124
Query: 107 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165
+ P+ V FYGA + +G++ ICME MD SLD QV+ + + IPE+ILGK+++++++
Sbjct: 125 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKEAKRIPEEILGKVSIAVLRG 180
Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225
L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YMAPER
Sbjct: 181 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMAPER- 238
Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDS---------WGTP------------- 263
L YSV+SDIWS+G++++ELA+ R+P +G P
Sbjct: 239 ---LQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSIS 295
Query: 264 -----------------------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300
F+ L +V EP P+LP F+ +F +F ++CL KN
Sbjct: 296 PRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPA 355
Query: 301 ERPTYPELMQHPFFTLHESKGTDVASFV 328
ER L H F E + D A ++
Sbjct: 356 ERADLKMLTNHTFIKRSEVEEVDFAGWL 383
>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
Length = 438
Score = 207 bits (528), Expect = 8e-54
Identities = 133/330 (40%), Positives = 186/330 (56%), Gaps = 30/330 (9%)
Query: 6 GKKRNPGLKIPKEA----FEQPQTSSTPPRDLDSKACISIGN--QNFEVKADDLEPIMEL 59
G++ GLK+ A P S + P + K+ + N ++ D+ L
Sbjct: 113 GERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTL 172
Query: 60 GRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL 119
G G G V K HVPSG+I+AVK I + + QK+++ +L+I + D + + FYGA
Sbjct: 173 GHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAF 231
Query: 120 FREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178
F E + IC E MD SLD + K +PE +LG+IAV++VK L +L S L ++HR
Sbjct: 232 FVENRISICTEFMDGGSLDVYRK--------MPEHVLGRIAVAVVKGLTYLWS-LKILHR 282
Query: 179 DVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKS 238
DVKPSN+L+N GQVK+CDFG+S LV+S+AKT G YMAPERI+ E Y + S
Sbjct: 283 DVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISGE----QYGIHS 337
Query: 239 DIWSLGITMIELAILRFPYDSWGT--PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 296
D+WSLGI+ +E+ + G+ P Q L+ +V+E SP LP +FS FV F +QC++
Sbjct: 338 DVWSLGISFMEI------QKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMR 391
Query: 297 KNSKERPTYPELMQHPFFTLHESKGTDVAS 326
K KERP ELM HPF V S
Sbjct: 392 KQPKERPAPEELMGHPFIVQFNDGNAAVVS 421
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 156 bits (394), Expect = 3e-38
Identities = 102/295 (34%), Positives = 159/295 (53%), Gaps = 21/295 (7%)
Query: 21 EQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMA 80
EQP + + L + + F+V + +LG G+YG V K H SGQ++A
Sbjct: 2 EQPPAPKSKLKKLSEDSLTKQPEEVFDV-------LEKLGEGSYGSVFKAIHKESGQVVA 54
Query: 81 VKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFY 140
+K++ + QE ++ ++ I M+ D P+ V +YG+ F+ D+WI ME
Sbjct: 55 IKQVPVESDLQE---IIKEISI-MQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDI 110
Query: 141 KQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI 200
++ +K T+ ED + I S +K LE+LH + IHRD+K N+L+N G K+ DFG+
Sbjct: 111 IRLRNK--TLIEDEIATILKSTLKGLEYLHF-MRKIHRDIKAGNILLNTEGHAKLADFGV 167
Query: 201 SGYLVDSVAK-TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259
+G L D++AK G +MAPE I + GY+ +DIWSLGIT IE+A + PY
Sbjct: 168 AGQLTDTMAKRNTVIGTPFWMAPEVI----QEIGYNCVADIWSLGITSIEMAEGKPPYAD 223
Query: 260 WGTPFQQLKQVVEEPSPQL-PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + + + P P + +S +F DF +CL KN ++R T +L+QHPF
Sbjct: 224 I-HPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPF 277
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 155 bits (393), Expect = 4e-38
Identities = 107/306 (34%), Positives = 163/306 (53%), Gaps = 20/306 (6%)
Query: 21 EQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMA 80
E Q + P R L S+ Q EV + + +LG G+YG V K H +GQI+A
Sbjct: 2 ETVQLRNPPRRQLKKLDEDSLTKQPEEV----FDVLEKLGEGSYGSVYKAIHKETGQIVA 57
Query: 81 VKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFY 140
+K++ + QE ++ ++ I M+ D P V +YG+ F+ D+WI ME
Sbjct: 58 IKQVPVESDLQE---IIKEISI-MQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDI 113
Query: 141 KQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI 200
++ +K T+ ED + I S +K LE+LH + IHRD+K N+L+N G K+ DFG+
Sbjct: 114 IRLRNK--TLTEDEIATILQSTLKGLEYLHF-MRKIHRDIKAGNILLNTEGHAKLADFGV 170
Query: 201 SGYLVDSVAK-TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259
+G L D++AK G +MAPE I + GY+ +DIWSLGIT IE+A + PY
Sbjct: 171 AGQLTDTMAKRNTVIGTPFWMAPEVI----QEIGYNCVADIWSLGITAIEMAEGKPPYAD 226
Query: 260 WGTPFQQLKQVVEEPSPQL-PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318
P + + + P P + +S F DF QCL K+ ++R T +L+QHPF +
Sbjct: 227 I-HPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPF--VRS 283
Query: 319 SKGTDV 324
+KG +
Sbjct: 284 AKGVSI 289
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 141 bits (355), Expect = 9e-34
Identities = 93/279 (33%), Positives = 149/279 (53%), Gaps = 13/279 (4%)
Query: 43 NQNFEVKADDLEP------IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL 96
++ +E DL+P + ELG GA+G V K ++ +G + A K I T + +E +
Sbjct: 20 SREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE-TKSEEELEDY 78
Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156
+++++I + T D P+ V GA + +G +WI +E +D+G T P+ +
Sbjct: 79 IVEIEI-LATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQ--IQ 135
Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGC 216
+ +++AL LHSK +IHRD+K NVL+ G +++ DFG+S + ++ K
Sbjct: 136 VVCRQMLEALNFLHSK-RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIG 194
Query: 217 KPY-MAPERINPE-LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274
PY MAPE + E + Y K+DIWSLGIT+IE+A + P+ LK +P
Sbjct: 195 TPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDP 254
Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
L K+S EF DF L KN + RP+ +L++HPF
Sbjct: 255 PTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPF 293
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 140 bits (353), Expect = 2e-33
Identities = 101/297 (34%), Positives = 147/297 (49%), Gaps = 20/297 (6%)
Query: 26 SSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR 85
S +P R LD I A E + +G G YG V K RHV +GQ+ A+K +
Sbjct: 3 SDSPARSLDE-----IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDK 138
T E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 58 VT--GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198
K KG T+ E+ + I I++ L HLH VIHRD+K NVL+ +VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 199 GISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFP 256
G+S L +V + PY MAPE I + N Y KSD+WSLGIT IE+A P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P+P+L + K+S +F F CL KN +RP +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 140 bits (353), Expect = 2e-33
Identities = 101/297 (34%), Positives = 147/297 (49%), Gaps = 20/297 (6%)
Query: 26 SSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR 85
S +P R LD I A E + +G G YG V K RHV +GQ+ A+K +
Sbjct: 3 SDSPARSLDE-----IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDK 138
T E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 58 VT--GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198
K KG T+ E+ + I I++ L HLH VIHRD+K NVL+ +VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 199 GISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFP 256
G+S L +V + PY MAPE I + N Y KSD+WSLGIT IE+A P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P+P+L + K+S +F F CL KN +RP +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 140 bits (353), Expect = 2e-33
Identities = 101/297 (34%), Positives = 147/297 (49%), Gaps = 20/297 (6%)
Query: 26 SSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR 85
S +P R LD I A E + +G G YG V K RHV +GQ+ A+K +
Sbjct: 3 SDSPARSLDE-----IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDK 138
T E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 58 VT--GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198
K KG T+ E+ + I I++ L HLH VIHRD+K NVL+ +VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 199 GISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFP 256
G+S L +V + PY MAPE I + N Y KSD+WSLGIT IE+A P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P+P+L + K+S +F F CL KN +RP +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 140 bits (353), Expect = 2e-33
Identities = 101/297 (34%), Positives = 147/297 (49%), Gaps = 20/297 (6%)
Query: 26 SSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR 85
S +P R LD I A E + +G G YG V K RHV +GQ+ A+K +
Sbjct: 3 SDSPARSLDE-----IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDK 138
T E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 58 VT--GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198
K KG T+ E+ + I I++ L HLH VIHRD+K NVL+ +VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 199 GISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFP 256
G+S L +V + PY MAPE I + N Y KSD+WSLGIT IE+A P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P+P+L + K+S +F F CL KN +RP +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 140 bits (353), Expect = 2e-33
Identities = 101/297 (34%), Positives = 147/297 (49%), Gaps = 20/297 (6%)
Query: 26 SSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR 85
S +P R LD I A E + +G G YG V K RHV +GQ+ A+K +
Sbjct: 3 SDSPARSLDE-----IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDK 138
T E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 58 VT--GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198
K KG T+ E+ + I I++ L HLH VIHRD+K NVL+ +VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 199 GISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFP 256
G+S L +V + PY MAPE I + N Y KSD+WSLGIT IE+A P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P+P+L + K+S +F F CL KN +RP +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 140 bits (353), Expect = 2e-33
Identities = 101/297 (34%), Positives = 147/297 (49%), Gaps = 20/297 (6%)
Query: 26 SSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR 85
S +P R LD I A E + +G G YG V K RHV +GQ+ A+K +
Sbjct: 3 SDSPARSLDE-----IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDK 138
T E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 58 VT--GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198
K KG T+ E+ + I I++ L HLH VIHRD+K NVL+ +VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 199 GISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFP 256
G+S L +V + PY MAPE I + N Y KSD+WSLGIT IE+A P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P+P+L + K+S +F F CL KN +RP +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 140 bits (353), Expect = 2e-33
Identities = 101/297 (34%), Positives = 147/297 (49%), Gaps = 20/297 (6%)
Query: 26 SSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR 85
S +P R LD I A E + +G G YG V K RHV +GQ+ A+K +
Sbjct: 3 SDSPARSLDE-----IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDK 138
T E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 58 VT--GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198
K KG T+ E+ + I I++ L HLH VIHRD+K NVL+ +VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 199 GISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFP 256
G+S L +V + PY MAPE I + N Y KSD+WSLGIT IE+A P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P+P+L + K+S +F F CL KN +RP +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 140 bits (353), Expect = 2e-33
Identities = 101/297 (34%), Positives = 147/297 (49%), Gaps = 20/297 (6%)
Query: 26 SSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR 85
S +P R LD I A E + +G G YG V K RHV +GQ+ A+K +
Sbjct: 3 SDSPARSLDE-----IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDK 138
T E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 58 VT--GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198
K KG T+ E+ + I I++ L HLH VIHRD+K NVL+ +VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 199 GISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFP 256
G+S L +V + PY MAPE I + N Y KSD+WSLGIT IE+A P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P+P+L + K+S +F F CL KN +RP +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 139 bits (349), Expect = 5e-33
Identities = 97/291 (33%), Positives = 149/291 (51%), Gaps = 15/291 (5%)
Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ 91
D +K+ + I + A E + +G G YG V K RHV +GQ+ A+K + T + +
Sbjct: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDKFYKQVI 144
E+ +L ++++ + T+YGA ++ +W+ ME S+ K
Sbjct: 64 EEIKL--EINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT- 120
Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204
KG T+ ED + I+ I++ L HLH VIHRD+K NVL+ +VK+ DFG+S L
Sbjct: 121 -KGNTLKEDWIAYISREILRGLAHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQL 178
Query: 205 VDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGT 262
+V + PY MAPE I + N Y +SD+WS GIT IE+A P
Sbjct: 179 DRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH- 237
Query: 263 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P P+L + K+S +F F CL KN +RP+ +L++HPF
Sbjct: 238 PMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 139 bits (349), Expect = 5e-33
Identities = 97/291 (33%), Positives = 149/291 (51%), Gaps = 15/291 (5%)
Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ 91
D +K+ + I + A E + +G G YG V K RHV +GQ+ A+K + T + +
Sbjct: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDKFYKQVI 144
E+ +L ++++ + T+YGA ++ +W+ ME S+ K
Sbjct: 64 EEIKL--EINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT- 120
Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204
KG T+ ED + I+ I++ L HLH VIHRD+K NVL+ +VK+ DFG+S L
Sbjct: 121 -KGNTLKEDWIAYISREILRGLAHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQL 178
Query: 205 VDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGT 262
+V + PY MAPE I + N Y +SD+WS GIT IE+A P
Sbjct: 179 DRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH- 237
Query: 263 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P P+L + K+S +F F CL KN +RP+ +L++HPF
Sbjct: 238 PMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 139 bits (349), Expect = 5e-33
Identities = 97/291 (33%), Positives = 149/291 (51%), Gaps = 15/291 (5%)
Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ 91
D +K+ + I + A E + +G G YG V K RHV +GQ+ A+K + T + +
Sbjct: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDKFYKQVI 144
E+ +L ++++ + T+YGA ++ +W+ ME S+ K
Sbjct: 64 EEIKL--EINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT- 120
Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204
KG T+ ED + I+ I++ L HLH VIHRD+K NVL+ +VK+ DFG+S L
Sbjct: 121 -KGNTLKEDWIAYISREILRGLAHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQL 178
Query: 205 VDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGT 262
+V + PY MAPE I + N Y +SD+WS GIT IE+A P
Sbjct: 179 DRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH- 237
Query: 263 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313
P + L + P P+L + K+S +F F CL KN +RP+ +L++HPF
Sbjct: 238 PMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 134 bits (337), Expect = 1e-31
Identities = 98/285 (34%), Positives = 144/285 (50%), Gaps = 13/285 (4%)
Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104
NF +D E +G+G YG V K+ + +GQ AVK + + E+ + + +I
Sbjct: 13 NFPDPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEE--IEAEYNILK 70
Query: 105 RTVDCPFTVTFYGALFREGDV-----WICMELMDT-SLDKFYKQVIDKGQTIPEDILGKI 158
D P V FYG F++ V W+ +EL S+ K + +G+ + E ++ I
Sbjct: 71 ALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYI 130
Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV-AKTIDAGCK 217
+ L+HLH+ IHRDVK +N+L+ G VK+ DFG+S L + + G
Sbjct: 131 LHEALMGLQHLHNN-KTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTP 189
Query: 218 PYMAPERINPELN-QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP 276
+MAPE I E Y + D WSLGIT IEL P P + L ++ P P
Sbjct: 190 FWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLH-PMRALFKIPRNPPP 248
Query: 277 QL-PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320
+L + +SAEF DF S+CL K+ ++RPT EL+QH F T E K
Sbjct: 249 KLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGK 293
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 132 bits (333), Expect = 3e-31
Identities = 92/269 (34%), Positives = 138/269 (51%), Gaps = 15/269 (5%)
Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113
E + +G G YG V K RHV +GQ+ A+K + T + +E+ + ++++ +
Sbjct: 26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE--IKQEINMLKKYSHHRNIA 83
Query: 114 TFYGALFREG------DVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166
T+YGA ++ +W+ ME S+ K KG + ED + I I++ L
Sbjct: 84 TYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT--KGNALKEDCIAYICREILRGL 141
Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERI 225
HLH+ VIHRD+K NVL+ +VK+ DFG+S L +V + PY MAPE I
Sbjct: 142 AHLHAH-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200
Query: 226 NPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284
+ N Y +SDIWSLGIT IE+A P P + L + P P+L + K+S
Sbjct: 201 ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPPPRLKSKKWS 259
Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPF 313
+F+DF CL K RP +L++ PF
Sbjct: 260 KKFIDFIDTCLIKTYLSRPPTEQLLKFPF 288
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 132 bits (333), Expect = 3e-31
Identities = 92/269 (34%), Positives = 138/269 (51%), Gaps = 15/269 (5%)
Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113
E + +G G YG V K RHV +GQ+ A+K + T + +E+ + ++++ +
Sbjct: 26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE--IKQEINMLKKYSHHRNIA 83
Query: 114 TFYGALFREG------DVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166
T+YGA ++ +W+ ME S+ K KG + ED + I I++ L
Sbjct: 84 TYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT--KGNALKEDCIAYICREILRGL 141
Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERI 225
HLH+ VIHRD+K NVL+ +VK+ DFG+S L +V + PY MAPE I
Sbjct: 142 AHLHAH-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200
Query: 226 NPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284
+ N Y +SDIWSLGIT IE+A P P + L + P P+L + K+S
Sbjct: 201 ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPPPRLKSKKWS 259
Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPF 313
+F+DF CL K RP +L++ PF
Sbjct: 260 KKFIDFIDTCLIKTYLSRPPTEQLLKFPF 288
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 132 bits (333), Expect = 3e-31
Identities = 92/269 (34%), Positives = 138/269 (51%), Gaps = 15/269 (5%)
Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113
E + +G G YG V K RHV +GQ+ A+K + T + +E+ + ++++ +
Sbjct: 26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE--IKQEINMLKKYSHHRNIA 83
Query: 114 TFYGALFREG------DVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166
T+YGA ++ +W+ ME S+ K KG + ED + I I++ L
Sbjct: 84 TYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT--KGNALKEDCIAYICREILRGL 141
Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERI 225
HLH+ VIHRD+K NVL+ +VK+ DFG+S L +V + PY MAPE I
Sbjct: 142 AHLHAH-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200
Query: 226 NPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284
+ N Y +SDIWSLGIT IE+A P P + L + P P+L + K+S
Sbjct: 201 ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPPPRLKSKKWS 259
Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPF 313
+F+DF CL K RP +L++ PF
Sbjct: 260 KKFIDFIDTCLIKTYLSRPPTEQLLKFPF 288
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 132 bits (333), Expect = 3e-31
Identities = 92/269 (34%), Positives = 138/269 (51%), Gaps = 15/269 (5%)
Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113
E + +G G YG V K RHV +GQ+ A+K + T + +E+ + ++++ +
Sbjct: 26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE--IKQEINMLKKYSHHRNIA 83
Query: 114 TFYGALFREG------DVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166
T+YGA ++ +W+ ME S+ K KG + ED + I I++ L
Sbjct: 84 TYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT--KGNALKEDCIAYICREILRGL 141
Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERI 225
HLH+ VIHRD+K NVL+ +VK+ DFG+S L +V + PY MAPE I
Sbjct: 142 AHLHAH-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200
Query: 226 NPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284
+ N Y +SDIWSLGIT IE+A P P + L + P P+L + K+S
Sbjct: 201 ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPPPRLKSKKWS 259
Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPF 313
+F+DF CL K RP +L++ PF
Sbjct: 260 KKFIDFIDTCLIKTYLSRPPTEQLLKFPF 288
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,740,980
Number of Sequences: 37866
Number of extensions: 552656
Number of successful extensions: 3431
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 509
Number of HSP's successfully gapped in prelim test: 281
Number of HSP's that attempted gapping in prelim test: 1606
Number of HSP's gapped (non-prelim): 935
length of query: 334
length of database: 18,247,518
effective HSP length: 103
effective length of query: 231
effective length of database: 14,347,320
effective search space: 3314230920
effective search space used: 3314230920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.