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Search of human proteins with 145699139
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145699139 cartilage intermediate layer protein 2 [Homo
sapiens]
(1156 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145699139 cartilage intermediate layer protein 2 [Homo sapiens] 2400 0.0
gi|192449445 cartilage intermediate layer protein [Homo sapiens] 1188 0.0
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 63 1e-09
gi|118572606 hemicentin 1 [Homo sapiens] 63 2e-09
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 62 2e-09
gi|4505737 complement factor properdin precursor [Homo sapiens] 61 7e-09
gi|223671861 complement factor properdin precursor [Homo sapiens] 61 7e-09
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 60 9e-09
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 59 2e-08
gi|134031945 SCO-spondin [Homo sapiens] 59 2e-08
gi|83281200 protogenin [Homo sapiens] 59 3e-08
gi|169202626 PREDICTED: similar to mucin 5, partial [Homo sapiens] 59 3e-08
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 59 3e-08
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 59 3e-08
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 58 6e-08
gi|147904700 semaphorin 5A [Homo sapiens] 57 8e-08
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 57 1e-07
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 57 1e-07
gi|13489095 sialoadhesin precursor [Homo sapiens] 57 1e-07
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 56 2e-07
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 56 2e-07
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 56 2e-07
gi|8923894 thrombospondin type I domain-containing 1 isoform 1 [... 56 2e-07
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 55 5e-07
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 54 7e-07
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 54 9e-07
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 54 9e-07
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 54 9e-07
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 53 2e-06
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 53 2e-06
>gi|145699139 cartilage intermediate layer protein 2 [Homo sapiens]
Length = 1156
Score = 2400 bits (6221), Expect = 0.0
Identities = 1156/1156 (100%), Positives = 1156/1156 (100%)
Query: 1 MASLLPLLCLCVVAAHLAGARDATPTEEPMATALGLERRSVYTGQPSPALEDWEEASEWT 60
MASLLPLLCLCVVAAHLAGARDATPTEEPMATALGLERRSVYTGQPSPALEDWEEASEWT
Sbjct: 1 MASLLPLLCLCVVAAHLAGARDATPTEEPMATALGLERRSVYTGQPSPALEDWEEASEWT 60
Query: 61 SWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSAVGERVHLNPTRG 120
SWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSAVGERVHLNPTRG
Sbjct: 61 SWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSAVGERVHLNPTRG 120
Query: 121 FWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDA 180
FWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDA
Sbjct: 121 FWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDA 180
Query: 181 CPGRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTPSGQPLLGARVSLRDQPGTVATS 240
CPGRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTPSGQPLLGARVSLRDQPGTVATS
Sbjct: 181 CPGRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTPSGQPLLGARVSLRDQPGTVATS 240
Query: 241 DAHGTFRVPGVCADSRANIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPES 300
DAHGTFRVPGVCADSRANIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPES
Sbjct: 241 DAHGTFRVPGVCADSRANIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPES 300
Query: 301 RVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCK 360
RVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCK
Sbjct: 301 RVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCK 360
Query: 361 AWNEAGAVRSGTARLTVLAPGQPACDPRPREYLIKLPEDCGQPGSGPAYLDVGLCPDTRC 420
AWNEAGAVRSGTARLTVLAPGQPACDPRPREYLIKLPEDCGQPGSGPAYLDVGLCPDTRC
Sbjct: 361 AWNEAGAVRSGTARLTVLAPGQPACDPRPREYLIKLPEDCGQPGSGPAYLDVGLCPDTRC 420
Query: 421 PSLAGSSPRCGDASSRCCSVRRLERREIHCPGYVLPVKVVAECGCQKCLPPRGLVRGRVV 480
PSLAGSSPRCGDASSRCCSVRRLERREIHCPGYVLPVKVVAECGCQKCLPPRGLVRGRVV
Sbjct: 421 PSLAGSSPRCGDASSRCCSVRRLERREIHCPGYVLPVKVVAECGCQKCLPPRGLVRGRVV 480
Query: 481 AADSGEPLRFARILLGQEPIGFTAYQGDFTIEVPPSTQRLVVTFVDPSGEFMDAVRVLPF 540
AADSGEPLRFARILLGQEPIGFTAYQGDFTIEVPPSTQRLVVTFVDPSGEFMDAVRVLPF
Sbjct: 481 AADSGEPLRFARILLGQEPIGFTAYQGDFTIEVPPSTQRLVVTFVDPSGEFMDAVRVLPF 540
Query: 541 DPRGAGVYHEVKAMRKKAPVILHTSQSNTIPLGELEDEAPLGELVLPSGAFRRADGKPYS 600
DPRGAGVYHEVKAMRKKAPVILHTSQSNTIPLGELEDEAPLGELVLPSGAFRRADGKPYS
Sbjct: 541 DPRGAGVYHEVKAMRKKAPVILHTSQSNTIPLGELEDEAPLGELVLPSGAFRRADGKPYS 600
Query: 601 GPVEARVTFVDPRDLTSAASAPSDLRFVDSDGELAPLRTYGMFSVDLRAPGSAEQLQVGP 660
GPVEARVTFVDPRDLTSAASAPSDLRFVDSDGELAPLRTYGMFSVDLRAPGSAEQLQVGP
Sbjct: 601 GPVEARVTFVDPRDLTSAASAPSDLRFVDSDGELAPLRTYGMFSVDLRAPGSAEQLQVGP 660
Query: 661 VAVRVAASQIHMPGHVEALKLWSLNPETGLWEEESGFRREGSSGPRVRREERVFLVGNVE 720
VAVRVAASQIHMPGHVEALKLWSLNPETGLWEEESGFRREGSSGPRVRREERVFLVGNVE
Sbjct: 661 VAVRVAASQIHMPGHVEALKLWSLNPETGLWEEESGFRREGSSGPRVRREERVFLVGNVE 720
Query: 721 IRERRLFNLDVPERRRCFVKVRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGR 780
IRERRLFNLDVPERRRCFVKVRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGR
Sbjct: 721 IRERRLFNLDVPERRRCFVKVRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGR 780
Query: 781 FDSAVTGPNGACLPAFCDADRPDAYTALVTATLGGEELEPAPSLPRPLPATVGVTQPYLD 840
FDSAVTGPNGACLPAFCDADRPDAYTALVTATLGGEELEPAPSLPRPLPATVGVTQPYLD
Sbjct: 781 FDSAVTGPNGACLPAFCDADRPDAYTALVTATLGGEELEPAPSLPRPLPATVGVTQPYLD 840
Query: 841 RLGYRRTDHDDPAFKRNGFRINLAKPRPGDPAEANGPVYPWRSLRECQGAPVTASHFRFA 900
RLGYRRTDHDDPAFKRNGFRINLAKPRPGDPAEANGPVYPWRSLRECQGAPVTASHFRFA
Sbjct: 841 RLGYRRTDHDDPAFKRNGFRINLAKPRPGDPAEANGPVYPWRSLRECQGAPVTASHFRFA 900
Query: 901 RVEADKYEYNVVPFREGTPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNAGG 960
RVEADKYEYNVVPFREGTPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNAGG
Sbjct: 901 RVEADKYEYNVVPFREGTPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNAGG 960
Query: 961 SHPRTRGQLYGLRDARSVRDPERPGTSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRR 1020
SHPRTRGQLYGLRDARSVRDPERPGTSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRR
Sbjct: 961 SHPRTRGQLYGLRDARSVRDPERPGTSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRR 1020
Query: 1021 VAVNGLLRDYLTRHPPPVPAEDPAAFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRC 1080
VAVNGLLRDYLTRHPPPVPAEDPAAFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRC
Sbjct: 1021 VAVNGLLRDYLTRHPPPVPAEDPAAFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRC 1080
Query: 1081 FDGSSDGFSREMKADAGTAVTFQCREPPAGRPSLFQRLLESPATALGDIRREMSEAAQAQ 1140
FDGSSDGFSREMKADAGTAVTFQCREPPAGRPSLFQRLLESPATALGDIRREMSEAAQAQ
Sbjct: 1081 FDGSSDGFSREMKADAGTAVTFQCREPPAGRPSLFQRLLESPATALGDIRREMSEAAQAQ 1140
Query: 1141 ARASGPLRTRRGRVRQ 1156
ARASGPLRTRRGRVRQ
Sbjct: 1141 ARASGPLRTRRGRVRQ 1156
>gi|192449445 cartilage intermediate layer protein [Homo sapiens]
Length = 1184
Score = 1188 bits (3074), Expect = 0.0
Identities = 578/1143 (50%), Positives = 756/1143 (66%), Gaps = 33/1143 (2%)
Query: 32 TALGLERRSVYTGQPSPAL-----EDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGP 86
T L R V G+ +P++ + E EWT+WFN+D+PGG GD+E L AIRFYYG
Sbjct: 24 TMLTQSVRRVQPGKKNPSIFAKPADTLESPGEWTTWFNIDYPGGKGDYERLDAIRFYYGD 83
Query: 87 ARVCPRPLALEARTTDWALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHVRFRCP-- 144
RVC RPL LEARTTDW + G+ VH +P GFWCLNREQ G+ CSNY VRF CP
Sbjct: 84 -RVCARPLRLEARTTDWTPAGSTGQVVHGSPREGFWCLNREQRPGQNCSNYTVRFLCPPG 142
Query: 145 -----LEASWGAWGPWGPCSGSCGP-GRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPG 198
E W W PW CS +CG G + R R C + C E Q C+ C
Sbjct: 143 SLRRDTERIWSPWSPWSKCSAACGQTGVQTRTRICLAEMVSLCSEASEEGQHCMGQDCTA 202
Query: 199 CSL-----------DTCECPDHILLGSVVTPSGQPLLGARVSLRDQ-PGTVATSDAHGTF 246
C L D C C D +L G+V P G P GA + L + P + +D+ G F
Sbjct: 203 CDLTCPMGQVNADCDACMCQDFMLHGAVSLPGGAPASGAAIYLLTKTPKLLTQTDSDGRF 262
Query: 247 RVPGVCADSRANIRAQMDGFSAGEAQAQANGSISVVTIILD--KLEKPYLVKHPESRVRE 304
R+PG+C D ++ ++ F A S+ TI + + E PY+V +PE++ R
Sbjct: 263 RIPGLCPDGKSILKITKVKF-APIVLTMPKTSLKAATIKAEFVRAETPYMVMNPETKARR 321
Query: 305 AGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCKAWNE 364
AGQ+V+ CCKA+G P P KY W+HN TLLD + + + L LR L+ QAG Y CKA ++
Sbjct: 322 AGQSVSLCCKATGKPRPDKYFWYHNDTLLDPSLYKHESKLVLRKLQQHQAGEYFCKAQSD 381
Query: 365 AGAVRSGTARLTVLAPGQPACDPRPREYLIKLPEDCGQPGSGPAYLDVGLCPDTRCPSLA 424
AGAV+S A+L V+A + C+P P YLI+LP DC Q + Y DVG CP C
Sbjct: 382 AGAVKSKVAQLIVIASDETPCNPVPESYLIRLPHDCFQNATNSFYYDVGRCPVKTCAGQQ 441
Query: 425 GSSPRCGDASSRCCSVRRLERREIHCPGYVLPVKVVAECGCQKCLPPRGLVRGRVVAADS 484
+ RC DA CC + + E REI C GY LP KV EC CQ+C R +VRGRV AAD+
Sbjct: 442 DNGIRCRDAVQNCCGISKTEEREIQCSGYTLPTKVAKECSCQRCTETRSIVRGRVSAADN 501
Query: 485 GEPLRFARILLGQEPIGFTAYQGDFTIEVPPSTQRLVVTFVDPSGEFMDAVRVLPFDPRG 544
GEP+RF + +G + T Y+G FT+ VP T+RLV+TFVD +F++ +VLPF+ +G
Sbjct: 502 GEPMRFGHVYMGNSRVSMTGYKGTFTLHVPQDTERLVLTFVDRLQKFVNTTKVLPFNKKG 561
Query: 545 AGVYHEVKAMRKKAPVILHTSQSNTIPLGELEDEAPLGELVLPSGAFRRADGKPYSGPVE 604
+ V+HE+K +R+K P+ L ++N IPLGE+ E P+ EL +PS +F R +G+PY G V+
Sbjct: 562 SAVFHEIKMLRRKEPITLEAMETNIIPLGEVVGEDPMAELEIPSRSFYRQNGEPYIGKVK 621
Query: 605 ARVTFVDPRDLTSAASAPSDLRFVDSDGELAPLRTYGMFSVDLRAPGSAEQLQVGPVAVR 664
A VTF+DPR++++A +A +DL F++ +G+ PLRTYGMFSVD R ++E L G V V
Sbjct: 622 ASVTFLDPRNISTATAAQTDLNFINDEGDTFPLRTYGMFSVDFRDEVTSEPLNAGKVKVH 681
Query: 665 VAASQIHMPGHVEALKLWSLNPETGLWEEESGFRREGSSGPRVRREERVFLVGNVEIRER 724
+ ++Q+ MP H+ +KLWSLNP+TGLWEEE F+ E R +RE+R FLVGN+EIRER
Sbjct: 682 LDSTQVKMPEHISTVKLWSLNPDTGLWEEEGDFKFENQR--RNKREDRTFLVGNLEIRER 739
Query: 725 RLFNLDVPERRRCFVKVRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGRFDSA 784
RLFNLDVPE RRCFVKVRAY +++F PSEQ++GVV++++NLEP GF +NPRAWGRFDS
Sbjct: 740 RLFNLDVPESRRCFVKVRAYRSERFLPSEQIQGVVISVINLEPRTGFLSNPRAWGRFDSV 799
Query: 785 VTGPNGACLPAFCDADRPDAYTALVTATLGGEELEPAPSLPRPLPATVGVTQPYLDRLGY 844
+TGPNGAC+PAFCD PDAY+A V A+L GEEL+ S P+ P +GV QPYL++L Y
Sbjct: 800 ITGPNGACVPAFCDDQSPDAYSAYVLASLAGEELQAVESSPKFNPNAIGVPQPYLNKLNY 859
Query: 845 RRTDHDDPAFKRNGFRINLAKPRPGDPAEANGPVYPWRSLRECQGAPVTASHFRFARVEA 904
RRTDH+DP K+ F+I++AKPRP E+NGP+Y + +LR C+ AP +A+HFRF ++E
Sbjct: 860 RRTDHEDPRVKKTAFQISMAKPRPNSAEESNGPIYAFENLRACEEAPPSAAHFRFYQIEG 919
Query: 905 DKYEYNVVPFREGTPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNAGGSHPR 964
D+Y+YN VPF E P SWT D LAWWP P EFRAC++KVKI GP E VRS N GG+H +
Sbjct: 920 DRYDYNTVPFNEDDPMSWTEDYLAWWPKPMEFRACYIKVKIVGPLEVNVRSRNMGGTHRQ 979
Query: 965 TRGQLYGLRDARSVRDPERPGTSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRRVAVN 1024
T G+LYG+RD RS RD ++P SAAC+EFKCSGML+DQ +VDRTLV ++PQGSCRR +VN
Sbjct: 980 TVGKLYGIRDVRSTRDRDQPNVSAACLEFKCSGMLYDQDRVDRTLVKVIPQGSCRRASVN 1039
Query: 1025 GLLRDYLTRHPPPVPAEDPAAFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRCFDGS 1084
+L +YL H P D + ++MLAPLDPLGHNYG+YTVTDQ PR AKEIA+GRCFDG+
Sbjct: 1040 PMLHEYLVNHLPLAVNNDTSEYTMLAPLDPLGHNYGIYTVTDQDPRTAKEIALGRCFDGT 1099
Query: 1085 SDGFSREMKADAGTAVTFQCREPPAGRPSLFQRLLESPA--TALGDIRREMSEAAQAQAR 1142
SDG SR MK++ G A+TF C E GR S FQ L +PA A G ++ + Q +A
Sbjct: 1100 SDGSSRIMKSNVGVALTFNCVERQVGRQSAFQYLQSTPAQSPAAGTVQGRVPSRRQQRAS 1159
Query: 1143 ASG 1145
G
Sbjct: 1160 RGG 1162
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 63.2 bits (152), Expect = 1e-09
Identities = 36/110 (32%), Positives = 48/110 (43%), Gaps = 20/110 (18%)
Query: 94 LALEARTTDWALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHVR--FRCPLEASWGA 151
L + + WA ++ GE G WC+N +C N R F P SWG
Sbjct: 519 LVCQTKHFPWADGTSCGE--------GKWCING------KCVNKTDRKHFDTPFHGSWGM 564
Query: 152 WGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCP 197
WGPWG CS +CG G + R C +P G C G+ + + C CP
Sbjct: 565 WGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 62.8 bits (151), Expect = 2e-09
Identities = 38/118 (32%), Positives = 49/118 (41%), Gaps = 12/118 (10%)
Query: 92 RPLALEARTTDWAL-PSAVGERVHLNPTRGFWCLNRE-QPRGRRCSNYHVRF------RC 143
+P ++ ++W+L N TR C N Q GR C V C
Sbjct: 4581 KPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPC 4640
Query: 144 PLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCP 197
P+ +W AW PWG CS SCG G + R R C +P G C G + Q C CP
Sbjct: 4641 PVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCP 4698
Score = 62.8 bits (151), Expect = 2e-09
Identities = 25/60 (41%), Positives = 32/60 (53%), Gaps = 4/60 (6%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCPG 198
CP++ SWG+W W CS SCG G + R+R C P G CPG + +C CPG
Sbjct: 4811 CPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACPG 4870
Score = 54.3 bits (129), Expect = 7e-07
Identities = 27/77 (35%), Positives = 34/77 (44%), Gaps = 10/77 (12%)
Query: 131 GRRCSNYHVRFR------CPLEASWGAWGPWGPCSGSCGPGRRLRRRHC----PSPAGDA 180
GR+C V+ CP +W W WG CS +C G+ R R C PS G A
Sbjct: 4736 GRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRA 4795
Query: 181 CPGRPLEAQKCVRPRCP 197
C G + Q+C CP
Sbjct: 4796 CGGPDSQIQRCNTDMCP 4812
Score = 53.5 bits (127), Expect = 1e-06
Identities = 45/188 (23%), Positives = 56/188 (29%), Gaps = 48/188 (25%)
Query: 45 QPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEA-RTTDW 103
+P P W SEW+ W G G+ R C P R +
Sbjct: 4581 KPCPVDGSW---SEWSLWEECTRSCGRGNQTR----------TRTCNNPSVQHGGRPCEG 4627
Query: 104 ALPSAVGERVHLNPTRGFW------------CLNREQPRGRRCSNYHVRF---------- 141
+ + P G W C Q R R C+N F
Sbjct: 4628 NAVEIIMCNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAET 4687
Query: 142 --------RCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQ 189
CP+ W W W CS SCG G R R R C P G C G +++
Sbjct: 4688 QMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSD 4747
Query: 190 KCVRPRCP 197
C CP
Sbjct: 4748 FCNSDPCP 4755
Score = 47.4 bits (111), Expect = 8e-05
Identities = 33/86 (38%), Positives = 38/86 (44%), Gaps = 9/86 (10%)
Query: 286 LDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGY----- 340
++ LE PY E R A Q + F C A GTP P W HNG L R G
Sbjct: 1264 VEDLEPPYNTTFQE---RVANQRIEFPCPAKGTPKP-TIKWLHNGRELTGREPGISILED 1319
Query: 341 GAHLELRGLRPDQAGIYHCKAWNEAG 366
G L + + P G Y C A NEAG
Sbjct: 1320 GTLLVIASVTPYDNGEYICVAVNEAG 1345
Score = 45.4 bits (106), Expect = 3e-04
Identities = 34/119 (28%), Positives = 51/119 (42%), Gaps = 8/119 (6%)
Query: 268 AGE--AQAQANGSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYS 325
AGE + G S ++ L E P + P+++ G V+ C A+G P P K +
Sbjct: 586 AGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKP-KIA 644
Query: 326 WFHNGTLLDRRAHGY----GAHLELRGLRPDQAGIYHCKAWNEAGAVRSGTARLTVLAP 380
W N + +H Y L ++ P AGIY C A N AG + + + AP
Sbjct: 645 WTVNDMFI-VGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAP 702
Score = 42.0 bits (97), Expect = 0.003
Identities = 19/57 (33%), Positives = 25/57 (43%), Gaps = 4/57 (7%)
Query: 145 LEASWGAWGPWGPCSGSCGPGRRLRRRHC----PSPAGDACPGRPLEAQKCVRPRCP 197
+ + W W CS +CG G + R R C P+ G C G LE + C CP
Sbjct: 4528 VHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCP 4584
Score = 40.8 bits (94), Expect = 0.008
Identities = 29/115 (25%), Positives = 47/115 (40%), Gaps = 5/115 (4%)
Query: 258 NIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASG 317
N+ + GF A A V++ + L P + P G+ + CKA+G
Sbjct: 4228 NVVLEDSGFYTCVANNAAGEDTHTVSLTVHVL--PTFTELPGDVSLNKGEQLRLSCKATG 4285
Query: 318 TPMPKKYSWFHNGTLLDRRAHGYGAHLEL--RGLRPDQAGIYHCKAWNEAGAVRS 370
P+P K +W N ++ H EL + + +G Y C A N G V++
Sbjct: 4286 IPLP-KLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKA 4339
Score = 39.3 bits (90), Expect = 0.022
Identities = 27/79 (34%), Positives = 36/79 (45%), Gaps = 5/79 (6%)
Query: 292 PYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGT--LLDRRAH--GYGAHLELR 347
P + + P+ + GQ V C A GTP+P +W G+ L+D H L +
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLP-VITWSKGGSTMLVDGEHHVSNPDGTLSID 1229
Query: 348 GLRPDQAGIYHCKAWNEAG 366
P AGIY C A N AG
Sbjct: 1230 QATPSDAGIYTCVATNIAG 1248
Score = 39.3 bits (90), Expect = 0.022
Identities = 35/128 (27%), Positives = 52/128 (40%), Gaps = 17/128 (13%)
Query: 268 AGEAQAQANGSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWF 327
AG+ + + ++ V I D+ + KH + + C ASG P P + W
Sbjct: 3882 AGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT---------CTASGVPFPSIH-WT 3931
Query: 328 HNGTLLDRRAHGY----GAHLELRGLRPDQAGIYHCKAWNEAGAVRSGTARLTVLAPGQP 383
NG L R GY +E+ + + AG Y C A N AG S +T+ P
Sbjct: 3932 KNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAG---SAHRHVTLHVHEPP 3988
Query: 384 ACDPRPRE 391
P+P E
Sbjct: 3989 VIQPQPSE 3996
Score = 38.1 bits (87), Expect = 0.049
Identities = 32/112 (28%), Positives = 52/112 (46%), Gaps = 7/112 (6%)
Query: 273 AQANGSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTL 332
AQ ++ I L+ P + H + V + +T C+A G P P +W +G
Sbjct: 4060 AQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLP-PPDITWHKDGRA 4118
Query: 333 L----DRRAHGYGAHLELRGLRPDQAGIYHCKAWNEAGAVRSGTARLTVLAP 380
+ +R G+ L++ ++P AG Y C A N AG+ + T +LTV P
Sbjct: 4119 IVESIRQRVLSSGS-LQIAFVQPGDAGHYTCMAANVAGSSSTST-KLTVHVP 4168
Score = 37.0 bits (84), Expect = 0.11
Identities = 23/67 (34%), Positives = 31/67 (46%), Gaps = 5/67 (7%)
Query: 306 GQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAH----GYGAHLELRGLRPDQAGIYHCKA 361
G + + C GTP P +W +G L AH +G L+L + +G Y C A
Sbjct: 3450 GSSTSMACITDGTPAPSM-AWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIA 3508
Query: 362 WNEAGAV 368
NEAG V
Sbjct: 3509 SNEAGEV 3515
Score = 35.4 bits (80), Expect = 0.32
Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 7/108 (6%)
Query: 277 GSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDR- 335
G + + + K + +P + + G N C+ G P P W G ++
Sbjct: 4335 GFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPT-IQWNRKGVDIEIS 4393
Query: 336 ---RAHGYGAHLELRGLRPDQAGIYHCKAWNEAGAVRSGTARLTVLAP 380
R G G+ L + G + AG Y C A NEAG V + LT+ +P
Sbjct: 4394 HRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMS-LTLQSP 4439
Score = 35.0 bits (79), Expect = 0.41
Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 5/59 (8%)
Query: 313 CKASGTPMPKKYSWFHNGTLLDRRAH----GYGAHLELRGLRPDQAGIYHCKAWNEAGA 367
CKA+G P+P +W+ + LL G +++ + AGIY C A N AGA
Sbjct: 1942 CKAAGNPVPV-ITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGA 1999
Score = 35.0 bits (79), Expect = 0.41
Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 5/74 (6%)
Query: 297 HPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDR----RAHGYGAHLELRGLRPD 352
+PE + C+A P P +WF +GT L+ R G L++ + D
Sbjct: 2581 NPEDVTVILNSPTSLVCEAYSYP-PATITWFKDGTPLESNRNIRILPGGRTLQILNAQED 2639
Query: 353 QAGIYHCKAWNEAG 366
AG Y C A NEAG
Sbjct: 2640 NAGRYSCVATNEAG 2653
Score = 33.5 bits (75), Expect = 1.2
Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 6/89 (6%)
Query: 296 KHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDR----RAHGYGAHLELRGLRP 351
+ PE+ +V+ C+ASG P+P +WF +G + R G L L
Sbjct: 2391 RSPENISVVEKNSVSLTCEASGIPLP-SITWFKDGWPVSLSNSVRILSGGRMLRLMQTTM 2449
Query: 352 DQAGIYHCKAWNEAGAVRSGTARLTVLAP 380
+ AG Y C N AG R L+VL P
Sbjct: 2450 EDAGQYTCVVRNAAGEERK-IFGLSVLVP 2477
Score = 33.1 bits (74), Expect = 1.6
Identities = 28/97 (28%), Positives = 38/97 (39%), Gaps = 9/97 (9%)
Query: 284 IILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPK-KYSWFHNGTLLDRRAHGYGA 342
I LD P ++ P E G NVT C G P P K+ N + R +
Sbjct: 785 ITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFS-RPFSVSS 843
Query: 343 HLELR-------GLRPDQAGIYHCKAWNEAGAVRSGT 372
+LR L G Y C+A N+ G ++S T
Sbjct: 844 ISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Score = 32.7 bits (73), Expect = 2.0
Identities = 21/67 (31%), Positives = 27/67 (40%), Gaps = 7/67 (10%)
Query: 306 GQNVTFCCKASGTPMPKKYSWFHNGTLLDR------RAHGYGAHLELRGLRPDQAGIYHC 359
G+NV C A+G P P W +G + R G+ L + G G Y C
Sbjct: 3261 GENVELVCNANGIPTP-LIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTC 3319
Query: 360 KAWNEAG 366
A N AG
Sbjct: 3320 VATNPAG 3326
Score = 32.3 bits (72), Expect = 2.7
Identities = 24/65 (36%), Positives = 31/65 (47%), Gaps = 5/65 (7%)
Query: 306 GQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGY--GAHLELRGLRP--DQAGIYHCKA 361
G VT CKASG P P W G L+ + + GA L + P +++G Y C A
Sbjct: 995 GIPVTLPCKASGNPKP-SVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTA 1053
Query: 362 WNEAG 366
N AG
Sbjct: 1054 TNTAG 1058
Score = 31.6 bits (70), Expect = 4.6
Identities = 36/141 (25%), Positives = 51/141 (36%), Gaps = 21/141 (14%)
Query: 245 TFRVPGVCADSRANIRAQMDGFSAGEAQAQA---NGSISVVTIILDKLEKPYLVKHPESR 301
T+ GV + NIR + G AQ I V T + + E Y V
Sbjct: 1674 TWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPP 1733
Query: 302 VREAGQNVTFC-----------CKASGTPMPKKYSWFHNGTLLDRRAHGY-----GAHLE 345
E G ++ C +G+P P W +G L+D R G+ G L
Sbjct: 1734 AIEGGDETSYFIVMVNNLLELDCHVTGSP-PPTIMWLKDGQLIDER-DGFKILLNGRKLV 1791
Query: 346 LRGLRPDQAGIYHCKAWNEAG 366
+ + G+Y C A N AG
Sbjct: 1792 IAQAQVSNTGLYRCMAANTAG 1812
Score = 31.2 bits (69), Expect = 6.0
Identities = 22/75 (29%), Positives = 34/75 (45%), Gaps = 7/75 (9%)
Query: 297 HPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGY-----GAHLELRGLRP 351
HP + G++++ C+ G P P +W +G L +A G G L+L+ +
Sbjct: 2298 HPTEIIVTRGKSISLECEVQGIP-PPTVTWMKDGHPL-IKAKGVEILDEGHILQLKNIHV 2355
Query: 352 DQAGIYHCKAWNEAG 366
G Y C A N AG
Sbjct: 2356 SDTGRYVCVAVNVAG 2370
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
[Homo sapiens]
Length = 1584
Score = 62.4 bits (150), Expect = 2e-09
Identities = 36/102 (35%), Positives = 48/102 (47%), Gaps = 15/102 (14%)
Query: 131 GRRCSNYHVRFR------CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP--AGDACP 182
G C + V R CP++ W AW WG CS +CG G + R R C P G AC
Sbjct: 501 GAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQ 560
Query: 183 GRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVV---TPSGQ 221
G E ++C RCP + E D G+V+ TP+G+
Sbjct: 561 GPQDEYRQCGTQRCP----EPHEICDEDNFGAVIWKETPAGE 598
Score = 58.2 bits (139), Expect = 5e-08
Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 8/79 (10%)
Query: 126 REQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP--AGDACPG 183
REQ R C+N V CP+ +W W PW CS +CG G R R R C P G+ C G
Sbjct: 395 REQ---RLCNNSAV---CPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEG 448
Query: 184 RPLEAQKCVRPRCPGCSLD 202
+ + C CPG ++D
Sbjct: 449 PEKQTKFCNIALCPGRAVD 467
Score = 53.9 bits (128), Expect = 9e-07
Identities = 50/180 (27%), Positives = 69/180 (38%), Gaps = 31/180 (17%)
Query: 44 GQPSPALEDWEEASEWTSWFNVDHPGGDG-DFESLAAIRFYY-----GPAR--------- 88
G P+P D A EW+ W G+G + + Y GP R
Sbjct: 346 GFPAPQTGD-PAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSA 404
Query: 89 VCPRPLALEARTTDWALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHVRFR------ 142
VCP A + + W+L S+ R + TR Q G C + +
Sbjct: 405 VCPVHGAWD-EWSPWSLCSSTCGRGFRDRTR---TCRPPQFGGNPCEGPEKQTKFCNIAL 460
Query: 143 CP---LEASWGAWGPWGPCSGSCGPGRRLRRRHC--PSPAGDACPGRPLEAQKCVRPRCP 197
CP ++ +W W W CS SC GR+ R R C PS G C G +E + C +CP
Sbjct: 461 CPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCP 520
Score = 42.4 bits (98), Expect = 0.003
Identities = 19/51 (37%), Positives = 23/51 (45%), Gaps = 3/51 (5%)
Query: 149 WGAWGPWGPCSGSCGPGRRLRRRHC---PSPAGDACPGRPLEAQKCVRPRC 196
W W WG C+ CG G + R R C P G C G E ++C R C
Sbjct: 264 WKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREAC 314
>gi|4505737 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 60.8 bits (146), Expect = 7e-09
Identities = 27/59 (45%), Positives = 32/59 (54%), Gaps = 4/59 (6%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPA---GDACPGRPLEAQKC-VRPRCP 197
CP W WGPW PCS +C G R RRR C PA G CPG+ E++ C + CP
Sbjct: 133 CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCP 191
Score = 56.6 bits (135), Expect = 1e-07
Identities = 33/95 (34%), Positives = 39/95 (41%), Gaps = 15/95 (15%)
Query: 114 HLNPTRGFWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPG----RRLR 169
H P G C + Q C V CP +W WGPW PCS SC G + R
Sbjct: 165 HPAPKCGGHCPGQAQ-ESEACDTQQV---CPTHGAWATWGPWTPCSASCHGGPHEPKETR 220
Query: 170 RRHCPS------PAGDACPGRPLEAQKCV-RPRCP 197
R C + P G CPG E ++C P CP
Sbjct: 221 SRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP 255
Score = 47.0 bits (110), Expect = 1e-04
Identities = 23/76 (30%), Positives = 31/76 (40%), Gaps = 11/76 (14%)
Query: 127 EQPRGRRCSNYHVRFR-------CPLEASWGAWGPWGPCSGSCGPGRRLRRRHC----PS 175
++P G+ C R CP+ WG WGP PC +CG G+ + +R C P
Sbjct: 231 QKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQ 290
Query: 176 PAGDACPGRPLEAQKC 191
G C G C
Sbjct: 291 HGGPFCAGDATRTHIC 306
Score = 43.5 bits (101), Expect = 0.001
Identities = 34/127 (26%), Positives = 44/127 (34%), Gaps = 23/127 (18%)
Query: 84 YGPARVCPRPLAL----EARTTDWALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHV 139
+GP CP L E RT + +P G + TR C N P
Sbjct: 263 WGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHIC-NTAVP---------- 311
Query: 140 RFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGC 199
CP++ W +WG W PC R ++ C G GR +K RC G
Sbjct: 312 ---CPVDGEWDSWGEWSPCI-----RRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQ 363
Query: 200 SLDTCEC 206
D C
Sbjct: 364 QQDIRHC 370
Score = 43.5 bits (101), Expect = 0.001
Identities = 24/64 (37%), Positives = 29/64 (45%), Gaps = 9/64 (14%)
Query: 118 TRGFWCLNREQPRGRRCSNYHVRFR-------CPLEASWGAWGPWGPCSGSCGPG-RRLR 169
+RG C R+ G RC+ R CPL+ SW W WG C CGP R R
Sbjct: 345 SRGRTCRGRKFD-GHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRAR 403
Query: 170 RRHC 173
+R C
Sbjct: 404 QRLC 407
Score = 39.3 bits (90), Expect = 0.022
Identities = 28/90 (31%), Positives = 33/90 (36%), Gaps = 15/90 (16%)
Query: 123 CLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACP 182
CLN +R R P W W W PCS +C G +LR R C G C
Sbjct: 57 CLNTAFAYQKRSGGLCQPCRSP---RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQ-CS 112
Query: 183 GRPLEAQKCVRPRCPGCSLDTCE----CPD 208
G+ V P L CE CP+
Sbjct: 113 GK-------VAPGTLEWQLQACEDQQCCPE 135
>gi|223671861 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 60.8 bits (146), Expect = 7e-09
Identities = 27/59 (45%), Positives = 32/59 (54%), Gaps = 4/59 (6%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPA---GDACPGRPLEAQKC-VRPRCP 197
CP W WGPW PCS +C G R RRR C PA G CPG+ E++ C + CP
Sbjct: 133 CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCP 191
Score = 56.6 bits (135), Expect = 1e-07
Identities = 33/95 (34%), Positives = 39/95 (41%), Gaps = 15/95 (15%)
Query: 114 HLNPTRGFWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPG----RRLR 169
H P G C + Q C V CP +W WGPW PCS SC G + R
Sbjct: 165 HPAPKCGGHCPGQAQ-ESEACDTQQV---CPTHGAWATWGPWTPCSASCHGGPHEPKETR 220
Query: 170 RRHCPS------PAGDACPGRPLEAQKCV-RPRCP 197
R C + P G CPG E ++C P CP
Sbjct: 221 SRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP 255
Score = 47.0 bits (110), Expect = 1e-04
Identities = 23/76 (30%), Positives = 31/76 (40%), Gaps = 11/76 (14%)
Query: 127 EQPRGRRCSNYHVRFR-------CPLEASWGAWGPWGPCSGSCGPGRRLRRRHC----PS 175
++P G+ C R CP+ WG WGP PC +CG G+ + +R C P
Sbjct: 231 QKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQ 290
Query: 176 PAGDACPGRPLEAQKC 191
G C G C
Sbjct: 291 HGGPFCAGDATRTHIC 306
Score = 43.5 bits (101), Expect = 0.001
Identities = 34/127 (26%), Positives = 44/127 (34%), Gaps = 23/127 (18%)
Query: 84 YGPARVCPRPLAL----EARTTDWALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHV 139
+GP CP L E RT + +P G + TR C N P
Sbjct: 263 WGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHIC-NTAVP---------- 311
Query: 140 RFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGC 199
CP++ W +WG W PC R ++ C G GR +K RC G
Sbjct: 312 ---CPVDGEWDSWGEWSPCI-----RRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQ 363
Query: 200 SLDTCEC 206
D C
Sbjct: 364 QQDIRHC 370
Score = 43.5 bits (101), Expect = 0.001
Identities = 24/64 (37%), Positives = 29/64 (45%), Gaps = 9/64 (14%)
Query: 118 TRGFWCLNREQPRGRRCSNYHVRFR-------CPLEASWGAWGPWGPCSGSCGPG-RRLR 169
+RG C R+ G RC+ R CPL+ SW W WG C CGP R R
Sbjct: 345 SRGRTCRGRKFD-GHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRAR 403
Query: 170 RRHC 173
+R C
Sbjct: 404 QRLC 407
Score = 39.3 bits (90), Expect = 0.022
Identities = 28/90 (31%), Positives = 33/90 (36%), Gaps = 15/90 (16%)
Query: 123 CLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACP 182
CLN +R R P W W W PCS +C G +LR R C G C
Sbjct: 57 CLNTAFAYQKRSGGLCQPCRSP---RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQ-CS 112
Query: 183 GRPLEAQKCVRPRCPGCSLDTCE----CPD 208
G+ V P L CE CP+
Sbjct: 113 GK-------VAPGTLEWQLQACEDQQCCPE 135
>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
Length = 1585
Score = 60.5 bits (145), Expect = 9e-09
Identities = 25/57 (43%), Positives = 30/57 (52%), Gaps = 2/57 (3%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHC--PSPAGDACPGRPLEAQKCVRPRCP 197
CP+E W WGPWGPCS SC G + R R C PA C G + ++C CP
Sbjct: 416 CPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECP 472
Score = 57.4 bits (137), Expect = 8e-08
Identities = 28/68 (41%), Positives = 32/68 (47%), Gaps = 5/68 (7%)
Query: 132 RRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHC--PSPAGDACPGRPLEAQ 189
R C+N CP+ W WG W CS SCG G R R R C P G AC G L+ +
Sbjct: 353 RPCNNSAT---CPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTK 409
Query: 190 KCVRPRCP 197
C CP
Sbjct: 410 LCSMAACP 417
Score = 49.3 bits (116), Expect = 2e-05
Identities = 46/186 (24%), Positives = 59/186 (31%), Gaps = 33/186 (17%)
Query: 37 ERRSVYTGQPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLAL 96
E R P WEE W SW G G + + C P L
Sbjct: 351 ETRPCNNSATCPVHGVWEE---WGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGP-EL 406
Query: 97 EARTTDWALPSAVGERVHLNPTRGFW------CLNREQPRGRRCS--------------- 135
+ + A G+ + P W C N Q R R+CS
Sbjct: 407 QTKLCSMAACPVEGQWLEWGP----WGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTD 462
Query: 136 -NYHVRFRCPL-EASWGAWGPWGPCSGSCGPGRRLRRRHCPSPA--GDACPGRPLEAQKC 191
CP ++ WG W W CS +C G + R R C + G C G E + C
Sbjct: 463 TRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPC 522
Query: 192 VRPRCP 197
RCP
Sbjct: 523 SEKRCP 528
Score = 41.2 bits (95), Expect = 0.006
Identities = 18/41 (43%), Positives = 22/41 (53%), Gaps = 1/41 (2%)
Query: 152 WGPWGPCSGSCGPGRRLRRRHC-PSPAGDACPGRPLEAQKC 191
W PW CS +CG G ++R R C SP G C G E + C
Sbjct: 315 WSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPC 355
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 59.3 bits (142), Expect = 2e-08
Identities = 32/103 (31%), Positives = 45/103 (43%), Gaps = 16/103 (15%)
Query: 116 NPTRGFWCLNREQPR--------GRRCSNYHVRFRCP----LEASWGAWGPWGPCSGSCG 163
+P ++C ++ P G+ C H + P + SWGAW P+G CS +CG
Sbjct: 519 HPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCG 578
Query: 164 PGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCPGCSLD 202
G + R R C +P G C G + Q C R CP D
Sbjct: 579 TGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLAD 621
Score = 37.4 bits (85), Expect = 0.083
Identities = 31/94 (32%), Positives = 37/94 (39%), Gaps = 22/94 (23%)
Query: 119 RGFWCLNREQPRG-RRCSNYHVRFRCPLEASWGAW--GPWGPCSGSCG-PGRRLRRRHCP 174
RGF C +P+ RR N P E S W G W PCS +CG G ++R C
Sbjct: 892 RGF-CAALSKPKAIRRACN-------PQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCI 943
Query: 175 SPAGD----------ACPGRPLEAQKCVRPRCPG 198
P D RP + C R CPG
Sbjct: 944 QPLHDNTTRSVHAKHCNDARPESRRACSRELCPG 977
Score = 33.9 bits (76), Expect = 0.92
Identities = 30/92 (32%), Positives = 36/92 (39%), Gaps = 15/92 (16%)
Query: 113 VHLNPTRGFWC--LNREQPRGRRCSNYHVRFRCPLEASWGAW--GPWGPCSGSCGPGRRL 168
+H N TR N +P RR + R CP G W GPW CS +CG G +
Sbjct: 946 LHDNTTRSVHAKHCNDARPESRRACS---RELCP-----GRWRAGPWSQCSVTCGNGTQE 997
Query: 169 RR---RHCPSPAGDACPGRPLEAQKCVRPRCP 197
R R G RP A+ C CP
Sbjct: 998 RPVLCRTADDSFGICQEERPETARTCRLGPCP 1029
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 59.3 bits (142), Expect = 2e-08
Identities = 33/83 (39%), Positives = 40/83 (48%), Gaps = 12/83 (14%)
Query: 134 CSNYHVRFRCPLE------ASWGAWGPWGPCSGSCGP-GRRLRRRHC----PSPAGDACP 182
CS H + C L+ +G W PWGPCS SCG G R R R C P+ +G C
Sbjct: 3793 CSCAHGKLSCSLDDCFEADGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCR 3852
Query: 183 GRPLEAQKCVRPRCPGCSLDTCE 205
G P + +C P CPG T E
Sbjct: 3853 G-PRQDLECPSPDCPGAEGSTVE 3874
Score = 58.2 bits (139), Expect = 5e-08
Identities = 29/74 (39%), Positives = 33/74 (44%), Gaps = 4/74 (5%)
Query: 129 PRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHC----PSPAGDACPGR 184
PR R S CP+ +W W WGPCS SCG G + R+R C P G CPG
Sbjct: 2538 PRDRFRSQSCFVQACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGA 2597
Query: 185 PLEAQKCVRPRCPG 198
E C C G
Sbjct: 2598 SQERAPCGLQPCSG 2611
Score = 57.8 bits (138), Expect = 6e-08
Identities = 48/144 (33%), Positives = 56/144 (38%), Gaps = 28/144 (19%)
Query: 89 VCPRPL--ALEARTTDWA------LPSAVGERVHLNPTR-----GFWCLN-REQPRGRRC 134
VCP P A T WA VG++ L R G WC N + RR
Sbjct: 3936 VCPGPGCGAGNCSWTSWAPWEPCSRSCGVGQQRRLRAYRPPGPGGHWCPNILTAYQERRF 3995
Query: 135 SNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQK 190
N CP+ W W PW C SCG G+ LR R C SP G C G +A+
Sbjct: 3996 CNLRA---CPVPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARL 4052
Query: 191 C----VRPRCP-GCSLDTC--ECP 207
C CP G + TC CP
Sbjct: 4053 CNPMPCEAGCPAGMEVVTCANRCP 4076
Score = 57.4 bits (137), Expect = 8e-08
Identities = 31/99 (31%), Positives = 42/99 (42%), Gaps = 8/99 (8%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPS--PAGDACPGRPLEAQKCVRPRCPGCS 200
CP+ + WG W PW CS C G + R R C S P CPG + + C C
Sbjct: 2827 CPVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAPGDTTCPGPHSQTRDCNTQPC---- 2882
Query: 201 LDTCECPDHILLGSVVTPSGQPLLGARVSLRDQPGTVAT 239
T +CP+++L S + R+ L PG T
Sbjct: 2883 --TAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECT 2919
Score = 57.4 bits (137), Expect = 8e-08
Identities = 30/84 (35%), Positives = 35/84 (41%), Gaps = 11/84 (13%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCPG 198
C WG WGPW CS SCG G R R R C P GD C G + + C CP
Sbjct: 3249 CDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQALPCPV 3308
Query: 199 CSLDTCECPDHILLGSVVTPSGQP 222
+ E G+ +P G P
Sbjct: 3309 TNCTAIE-------GAEYSPCGPP 3325
Score = 56.6 bits (135), Expect = 1e-07
Identities = 25/54 (46%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 148 SWGAWGPWGPCSGSCGPGRRLRRRHCPSPAG----DACPGRPLEAQKCVRPRCP 197
+WG W PWGPCS +CGP + R R C SP G CPG ++Q C CP
Sbjct: 1696 AWGPWSPWGPCSRTCGPWGQGRSRRC-SPLGLLVLQNCPGPEHQSQACFTAACP 1748
Score = 56.2 bits (134), Expect = 2e-07
Identities = 28/71 (39%), Positives = 32/71 (45%), Gaps = 12/71 (16%)
Query: 149 WGAWGPWGPCSGSC-----GPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCSL-- 201
W W W CS SC GPG R R R CPSP +CPG + + C P CP S+
Sbjct: 2775 WTPWTSWSSCSQSCLAPGGGPGWRSRSRLCPSPGDSSCPGDATQEEPCSPPVCPVPSIWG 2834
Query: 202 -----DTCECP 207
TC P
Sbjct: 2835 LWAPWSTCSAP 2845
Score = 55.1 bits (131), Expect = 4e-07
Identities = 25/59 (42%), Positives = 30/59 (50%), Gaps = 5/59 (8%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRC--PGC 199
CP W +WGPW CS SCG G +LR R C P CPG +++ C C GC
Sbjct: 3642 CPDPGVWSSWGPWEDCSVSCGGGEQLRSRRCARP---PCPGPARQSRTCSTQVCREAGC 3697
Score = 53.5 bits (127), Expect = 1e-06
Identities = 39/124 (31%), Positives = 51/124 (41%), Gaps = 19/124 (15%)
Query: 128 QPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRR-RHCPSP-AGDACPGRP 185
Q + C +Y CP++ +WG WGPW PC G R R P+P G CPG
Sbjct: 3457 QHQREACPSYAT---CPVDGAWGPWGPWSPCDMCLGQSHRSRACSRPPTPEGGRPCPGNH 3513
Query: 186 LEAQKCVR--PRCPGC----SLDTC--ECP---DHILLGSVVTPSG---QPLLGARVSLR 231
+++ C +C C SL C CP + GSV P QP G +
Sbjct: 3514 TQSRPCQENSTQCTDCGGGQSLHPCGQPCPRSCQDLSPGSVCQPGSVGCQPTCGCPLGQL 3573
Query: 232 DQPG 235
Q G
Sbjct: 3574 SQDG 3577
Score = 50.8 bits (120), Expect = 7e-06
Identities = 22/57 (38%), Positives = 24/57 (42%), Gaps = 1/57 (1%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGC 199
CP W WGPW PC C G RLR R + G C P + C CP C
Sbjct: 4612 CPDSCQWSLWGPWSPCQVPCSGGFRLRWREAEALCGGGC-REPWAQESCNGGPCPEC 4667
Score = 50.4 bits (119), Expect = 9e-06
Identities = 35/104 (33%), Positives = 39/104 (37%), Gaps = 18/104 (17%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKC------- 191
CPL W AW W PC SCG G R R R +P G C G E Q C
Sbjct: 2712 CPLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTE 2771
Query: 192 VRPRCPGCSLDTCECPDHILLGSVVTPSGQPLLGARVSLRDQPG 235
V P S +C S + P G P +R L PG
Sbjct: 2772 VFGWTPWTSWSSCS-------QSCLAPGGGPGWRSRSRLCPSPG 2808
Score = 48.5 bits (114), Expect = 4e-05
Identities = 25/60 (41%), Positives = 27/60 (45%), Gaps = 5/60 (8%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPG-----RPLEAQKCVRPRCP 197
CP +WGPWGPCS SCGPG R CP A P L+ Q C CP
Sbjct: 4304 CPGLLEACSWGPWGPCSRSCGPGLASRSGSCPCLMAKADPTCNSTFLHLDTQGCYSGPCP 4363
Score = 48.1 bits (113), Expect = 5e-05
Identities = 25/67 (37%), Positives = 31/67 (46%), Gaps = 6/67 (8%)
Query: 143 CPLEASWGAWGPWGPCSGSC-GPGRRLRRRHCPSPAGDACPGRP--LEAQKCVRPRCP-- 197
CP++ W W PW CS C G R R+ H P G C P L + + +P CP
Sbjct: 1747 CPVDGEWSTWSPWSVCSEPCRGTMTRQRQCHSPQNGGRTCAALPGGLHSTRQTKP-CPQD 1805
Query: 198 GCSLDTC 204
GC TC
Sbjct: 1806 GCPNATC 1812
Score = 48.1 bits (113), Expect = 5e-05
Identities = 24/61 (39%), Positives = 28/61 (45%), Gaps = 4/61 (6%)
Query: 142 RCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCP 197
RCP+ W W W CS SC G R R R +P G C G +EA+ C CP
Sbjct: 2981 RCPVACGWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPCP 3040
Query: 198 G 198
G
Sbjct: 3041 G 3041
Score = 47.0 bits (110), Expect = 1e-04
Identities = 25/68 (36%), Positives = 28/68 (41%), Gaps = 8/68 (11%)
Query: 146 EASWGAWGPWGPCSGSCGPGRRLRRRHCP-SPAGDACPGRPLEAQKCVRPRCPG------ 198
E +W W PW CS SCGP R R R C SP+ PL P C G
Sbjct: 3183 EPTWSPWTPWSQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEE 3242
Query: 199 -CSLDTCE 205
C L C+
Sbjct: 3243 PCLLQGCD 3250
Score = 46.6 bits (109), Expect = 1e-04
Identities = 24/75 (32%), Positives = 31/75 (41%), Gaps = 8/75 (10%)
Query: 130 RGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGP-----GRRLRRRHCPSPAGDACPGR 184
R RRC + C ++ W +W PW C G CG R PS G C G
Sbjct: 1896 RPRRC---RLNPDCAVDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGI 1952
Query: 185 PLEAQKCVRPRCPGC 199
+A++C C GC
Sbjct: 1953 HRKARRCQTEPCEGC 1967
Score = 45.8 bits (107), Expect = 2e-04
Identities = 21/56 (37%), Positives = 28/56 (50%), Gaps = 2/56 (3%)
Query: 144 PLEASWGAWGPWGPCSGSCGP-GRRLRRRHCPSPA-GDACPGRPLEAQKCVRPRCP 197
P +W W W PCS SCGP G++ R R S + C ++Q C +P CP
Sbjct: 4157 PTHCAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQPSCP 4212
Score = 44.7 bits (104), Expect = 5e-04
Identities = 25/72 (34%), Positives = 28/72 (38%), Gaps = 15/72 (20%)
Query: 145 LEASWGAWGPWGPCSGSC----GPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRC---- 196
L WG W W PCS SC P R R R C + G PL+ + C P C
Sbjct: 3879 LPGGWGPWSSWSPCSRSCTDPARPAWRSRTRLC---LANCTMGDPLQERPCNLPSCTELP 3935
Query: 197 ----PGCSLDTC 204
PGC C
Sbjct: 3936 VCPGPGCGAGNC 3947
Score = 39.3 bits (90), Expect = 0.022
Identities = 26/76 (34%), Positives = 33/76 (43%), Gaps = 10/76 (13%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCSLD 202
CP+ G W W CS CG G R R C G A P +AQ + + C+L
Sbjct: 4763 CPV---LGPWSAWSSCSAPCGGGTMERHRTCEGGPGVA----PCQAQDTEQRQ--ECNLQ 4813
Query: 203 TC-ECPDHILLGSVVT 217
C ECP +L + T
Sbjct: 4814 PCPECPPGQVLSACAT 4829
Score = 38.9 bits (89), Expect = 0.029
Identities = 35/137 (25%), Positives = 42/137 (30%), Gaps = 27/137 (19%)
Query: 144 PLEASWGAWGPWGPCSGSCGPGRRLRRR---------------HCPSPAGDACPGRPLEA 188
P G WGPW PCS CG G R R R C P CP R +
Sbjct: 3038 PCPGPGGEWGPWSPCSVPCGGGYRNRTRGSSRSLMEFSTCGLQPCAGPVPGMCP-RDKQW 3096
Query: 189 QKCVRPRCPGCSLDT-----------CECPDHILLGSVVTPSGQPLLGARVSLRDQPGTV 237
C + L C CP +LL + V Q A PG+
Sbjct: 3097 LDCAQGPASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCPCAHEGHLYPPGST 3156
Query: 238 ATSDAHGTFRVPGVCAD 254
V G+ A+
Sbjct: 3157 VVRPCENCSCVSGLIAN 3173
Score = 38.1 bits (87), Expect = 0.049
Identities = 20/66 (30%), Positives = 28/66 (42%), Gaps = 8/66 (12%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHC----PSPAGDACPGRPLEAQKCVRPRCPG 198
C + +W W W C SCG G ++R R C P C G + + + CPG
Sbjct: 4250 CAVPEAWTLWSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQTR---QQPCPG 4306
Query: 199 CSLDTC 204
L+ C
Sbjct: 4307 L-LEAC 4311
Score = 37.7 bits (86), Expect = 0.064
Identities = 24/67 (35%), Positives = 26/67 (38%), Gaps = 7/67 (10%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHC----PSPAGDACPGRPLEA-QKCVRPRCP 197
CP+ W W W CS C R R R C P G C G EA + R CP
Sbjct: 3405 CPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQREACP 3464
Query: 198 GCSLDTC 204
S TC
Sbjct: 3465 --SYATC 3469
Score = 37.4 bits (85), Expect = 0.083
Identities = 17/48 (35%), Positives = 21/48 (43%), Gaps = 2/48 (4%)
Query: 152 WGPWGPCSGSCGPGRRLRRRHC--PSPAGDACPGRPLEAQKCVRPRCP 197
W W CS SCG G +R+ P G +CP +Q C CP
Sbjct: 2506 WSVWSSCSRSCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSCFVQACP 2553
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 58.5 bits (140), Expect = 3e-08
Identities = 40/124 (32%), Positives = 56/124 (45%), Gaps = 4/124 (3%)
Query: 257 ANIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKAS 316
+++R Q G A + +V L L P V+ PES R F C+A
Sbjct: 292 SDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAE 351
Query: 317 GTPMPKKYSWFHNGTLL--DRRAHGYGAHLELRGLRPDQAGIYHCKAWNEAGAVRSGTAR 374
G P P K SW NG + + R Y + L + + P+ IY C A N G++ S AR
Sbjct: 352 GIPSP-KMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILS-RAR 409
Query: 375 LTVL 378
LTV+
Sbjct: 410 LTVV 413
Score = 35.4 bits (80), Expect = 0.32
Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 9/91 (9%)
Query: 295 VKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRR------AHGYGAHLELRG 348
VK P+ V C+A G +P K +W NG + ++G E+ G
Sbjct: 42 VKEPQDVTVTRKDPVVLDCQAHGE-VPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEG 100
Query: 349 LRPDQA--GIYHCKAWNEAGAVRSGTARLTV 377
R +Q+ G Y C A N+ GA+ S A L +
Sbjct: 101 RRGEQSDEGFYQCLAMNKYGAILSQKAHLAL 131
Score = 34.3 bits (77), Expect = 0.70
Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 21/124 (16%)
Query: 292 PYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSW----FHNGTLLDRRAHGYGAHLELR 347
P ++ P++ Q V C A+G P P SW + + + R G G +L +
Sbjct: 235 PTIIAGPQNITTSLHQTVVLECMATGNPKP-IISWSRLDHKSIDVFNTRVLGNG-NLMIS 292
Query: 348 GLRPDQAGIYHCKAWNEAGAVRSGT---ARLTVLAPGQPACDPRPREYLIKLPEDCGQPG 404
+R AG+Y C+A R+ T A LTVLAP ++ PE +P
Sbjct: 293 DVRLQHAGVYVCRA--TTPGTRNFTVAMATLTVLAPPS----------FVEWPESLTRPR 340
Query: 405 SGPA 408
+G A
Sbjct: 341 AGTA 344
>gi|169202626 PREDICTED: similar to mucin 5, partial [Homo sapiens]
Length = 2013
Score = 58.5 bits (140), Expect = 3e-08
Identities = 38/97 (39%), Positives = 52/97 (53%), Gaps = 10/97 (10%)
Query: 59 WTSWFNVDHPG---GDGDFESLAAIRFYYGPARVCPRPLALEARTTDW-ALP-SAVGERV 113
W+ W +V PG GDF++L +R + RVC P ++E R D +P A+G+RV
Sbjct: 1389 WSPWMDVSRPGRGTDSGDFDTLENLRAH--GYRVCESPRSVECRAEDAPGVPLRALGQRV 1446
Query: 114 HLNPTRGFWCLNREQPRGRRCSNYHVRFRC--PLEAS 148
+P G C NREQ G C NY +R +C PL S
Sbjct: 1447 QCSPDVGLTCRNREQASG-LCYNYQIRVQCCTPLACS 1482
Score = 41.6 bits (96), Expect = 0.004
Identities = 35/131 (26%), Positives = 53/131 (40%), Gaps = 17/131 (12%)
Query: 26 TEEPMATALGLERRSVYTG--QPSPALEDWEEASEWTSWFNVDHP-----GGDGDFESLA 78
TE+P AT+ G + T +P + WT WF+VD P GGD + +
Sbjct: 1714 TEQPTATSRGGPTATSVTQGTHTTPVTRNCHPRCTWTKWFDVDFPSPGPHGGDKETYN-- 1771
Query: 79 AIRFYYGPARVCPRP-----LALEARTTDWALPSAVGERVHLNPTRGFWCLNREQPRG-R 132
++C RP L A++ +G+ V + G C N++Q +
Sbjct: 1772 --NIIRSGEKICRRPEEITRLQCRAKSHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPFK 1829
Query: 133 RCSNYHVRFRC 143
C NY VR C
Sbjct: 1830 MCLNYEVRVLC 1840
Score = 37.7 bits (86), Expect = 0.064
Identities = 25/93 (26%), Positives = 40/93 (43%), Gaps = 4/93 (4%)
Query: 54 EEASEWTSWFNVDHPG---GDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSAVG 110
+E WT W + +P GDF++ +R PR + A + + +G
Sbjct: 1579 QELCTWTEWIDGSYPAPGINGGDFDTFQNLRDEGYTFCESPRSVQCRAESFPNTPLADLG 1638
Query: 111 ERVHLNPTRGFWCLNREQPRGRRCSNYHVRFRC 143
+ V + T G CLN+ Q C NY +R +C
Sbjct: 1639 QDVICSHTEGLICLNKNQ-LPPICYNYEIRIQC 1670
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 58.5 bits (140), Expect = 3e-08
Identities = 37/97 (38%), Positives = 50/97 (51%), Gaps = 10/97 (10%)
Query: 295 VKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAH----GYGAHLELRGLR 350
V+HP+S R AG F C+A G P P +W NG +L H + L + G+
Sbjct: 333 VQHPQSISRPAGTTAMFTCQAQGEP-PPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIG 391
Query: 351 PDQAGIYHCKAWNEAGAVRSGTARLTVL----APGQP 383
P+ IY C A N AG+ ++ +ARLTVL PG P
Sbjct: 392 PEDEAIYQCVAENSAGSSQA-SARLTVLWAEGLPGPP 427
Score = 48.1 bits (113), Expect = 5e-05
Identities = 33/92 (35%), Positives = 42/92 (45%), Gaps = 5/92 (5%)
Query: 297 HPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYG----AHLELRGLRPD 352
HP++ V E G F C+ G P P +W N +D Y L++ GLR +
Sbjct: 144 HPQATVGEEGGVARFQCQIHGLPKPL-ITWEKNRVPIDTDNERYTLLPKGVLQITGLRAE 202
Query: 353 QAGIYHCKAWNEAGAVRSGTARLTVLAPGQPA 384
GI+HC A N A S ARLTV G A
Sbjct: 203 DGGIFHCVASNIASIRISHGARLTVSGSGSGA 234
Score = 38.9 bits (89), Expect = 0.029
Identities = 28/87 (32%), Positives = 34/87 (39%), Gaps = 10/87 (11%)
Query: 298 PESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGY---GAHLELRGLR---- 350
P V GQ + C+ GTP P + +W NG L H L +R R
Sbjct: 48 PSDDVAVPGQPIVLDCRVEGTP-PVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPG 106
Query: 351 --PDQAGIYHCKAWNEAGAVRSGTARL 375
P G Y C A N G V S AR+
Sbjct: 107 GSPSDEGDYECVAQNRFGLVVSRKARI 133
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 58.5 bits (140), Expect = 3e-08
Identities = 25/59 (42%), Positives = 27/59 (45%), Gaps = 4/59 (6%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHC----PSPAGDACPGRPLEAQKCVRPRCP 197
CP+ +W W W PCS SCG G R R C PSP D C G E C CP
Sbjct: 907 CPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACP 965
Score = 53.5 bits (127), Expect = 1e-06
Identities = 22/55 (40%), Positives = 31/55 (56%), Gaps = 2/55 (3%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCP 197
CP+ W +WG W CS +CG G + RRR C + G++C G +E + C CP
Sbjct: 719 CPVPIFWASWGSWSKCSSNCGGGMQSRRRACEN--GNSCLGCGVEFKTCNPEGCP 771
Score = 50.8 bits (120), Expect = 7e-06
Identities = 23/57 (40%), Positives = 27/57 (47%), Gaps = 4/57 (7%)
Query: 145 LEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCP 197
+ W AWGPW CS C G R+R+R C +P G C G E Q C CP
Sbjct: 852 VSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACP 908
Score = 45.4 bits (106), Expect = 3e-04
Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPA----GDACPGRPLEAQKC 191
C +W W W CS SCG G ++R+R C +PA G C G+ E + C
Sbjct: 661 CSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFC 713
Score = 36.2 bits (82), Expect = 0.19
Identities = 28/101 (27%), Positives = 35/101 (34%), Gaps = 6/101 (5%)
Query: 101 TDWALPSAVGERVHLNPTRGFWCLNREQPRGRR-CSNYHVRFR-CPLEASWGAWGPWGPC 158
T W+ SA H TR C + G C H C +A W PW
Sbjct: 917 TSWSPCSASCGGGHYQRTRS--CTSPAPSPGEDICLGLHTEEALCATQACPEGWSPWSEW 974
Query: 159 SGSCGPGRRLRRRHCPS--PAGDACPGRPLEAQKCVRPRCP 197
S G + R RHC P AC G +++ C P
Sbjct: 975 SKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEIP 1015
Score = 32.3 bits (72), Expect = 2.7
Identities = 22/67 (32%), Positives = 26/67 (38%), Gaps = 20/67 (29%)
Query: 143 CPL-----EASWGAWGPWGPC-------SGSCGPGRRLRRRHCPSP----AGDACPGRPL 186
CP+ + +G W PW PC SGSC R R C SP G C G +
Sbjct: 601 CPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSC----LCRARSCDSPRPRCGGLDCLGPAI 656
Query: 187 EAQKCVR 193
C R
Sbjct: 657 HIANCSR 663
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 57.8 bits (138), Expect = 6e-08
Identities = 27/68 (39%), Positives = 33/68 (48%), Gaps = 6/68 (8%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCP- 197
CP++ W W PW C+ +C G R R R C SP G AC G E Q C + CP
Sbjct: 491 CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPV 550
Query: 198 -GCSLDTC 204
GC + C
Sbjct: 551 DGCLSNPC 558
Score = 48.1 bits (113), Expect = 5e-05
Identities = 25/70 (35%), Positives = 28/70 (40%), Gaps = 4/70 (5%)
Query: 132 RRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLE 187
R CS R + W W PW CS +CG G R R C SP G C G E
Sbjct: 423 RACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRE 482
Query: 188 AQKCVRPRCP 197
+ C CP
Sbjct: 483 TKACQGAPCP 492
Score = 40.0 bits (92), Expect = 0.013
Identities = 16/51 (31%), Positives = 23/51 (45%), Gaps = 1/51 (1%)
Query: 146 EASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRC 196
E W W W CS +CG G + R R C + C G ++ + C +C
Sbjct: 381 EEGWSPWAEWTQCSVTCGSGTQQRGRSC-DVTSNTCLGPSIQTRACSLSKC 430
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 57.4 bits (137), Expect = 8e-08
Identities = 24/59 (40%), Positives = 29/59 (49%), Gaps = 4/59 (6%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPA----GDACPGRPLEAQKCVRPRCP 197
CP++ W W PW CS +CG G +R R C +PA GD C G E C CP
Sbjct: 838 CPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCP 896
Score = 54.3 bits (129), Expect = 7e-07
Identities = 35/92 (38%), Positives = 42/92 (45%), Gaps = 9/92 (9%)
Query: 109 VGERVHLNPTR---GFWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPG 165
V +R NPT G C+ Q R R N H+ CP W WGPW C+ CG G
Sbjct: 617 VRQRSCSNPTPRHGGRVCVG--QNREERYCNEHLL--CPPHMFWTGWGPWERCTAQCGGG 672
Query: 166 RRLRRRHCPSPAGDACPGRPLEAQKCVRPRCP 197
+ RRR C + G C G +E Q C CP
Sbjct: 673 IQARRRICEN--GPDCAGCNVEYQSCNTNPCP 702
Score = 48.1 bits (113), Expect = 5e-05
Identities = 50/183 (27%), Positives = 68/183 (37%), Gaps = 21/183 (11%)
Query: 29 PMATALGLERRSVYTGQPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPAR 88
P +E +S T P P L+ + + WT W V+ G +E RF Y
Sbjct: 684 PDCAGCNVEYQSCNTN-PCPELK---KTTPWTPWTPVNISDNGGHYEQ----RFRYTCKA 735
Query: 89 VCPRPLALEARTTDWALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHVRFRCPLEAS 148
P LE + + T G L+ + R R S + V +
Sbjct: 736 RLADPNLLEVGRQRIEMRYCSSDGTSGCSTDG---LSGDFLRAGRYSAHTVN------GA 786
Query: 149 WGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCPGCSLDTC 204
W AW W CS C G R R+R C +P G C G LE Q+C CP + +C
Sbjct: 787 WSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSC 846
Query: 205 ECP 207
P
Sbjct: 847 WSP 849
Score = 45.4 bits (106), Expect = 3e-04
Identities = 19/53 (35%), Positives = 26/53 (49%), Gaps = 4/53 (7%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKC 191
C W W W PCS +CG G ++R+R C +P G C G+ E + C
Sbjct: 592 CSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYC 644
Score = 37.0 bits (84), Expect = 0.11
Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 5/51 (9%)
Query: 144 PLEASWGAWGPWGPCSGSCGPGRRLRRRHCPS--PAGDACPGRPLEAQKCV 192
P SW W W C S G ++R R C P G C G E++ CV
Sbjct: 894 PCPESWSEWSDWSECEAS---GVQVRARQCILLFPMGSQCSGNTTESRPCV 941
Score = 36.2 bits (82), Expect = 0.19
Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 7/56 (12%)
Query: 145 LEASWGAWGPWGPCS---GSCGPGRRLRRRHCPSPA----GDACPGRPLEAQKCVR 193
++ +G W PW PC+ GS R R C SPA G C G +E C R
Sbjct: 539 VDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSR 594
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 56.6 bits (135), Expect = 1e-07
Identities = 27/68 (39%), Positives = 33/68 (48%), Gaps = 6/68 (8%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCP- 197
CP+ WG W PW CS +CG G + R R C +P G C G E Q C + CP
Sbjct: 489 CPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPI 548
Query: 198 -GCSLDTC 204
GC + C
Sbjct: 549 DGCLSNPC 556
Score = 51.2 bits (121), Expect = 6e-06
Identities = 30/96 (31%), Positives = 37/96 (38%), Gaps = 21/96 (21%)
Query: 123 CLNREQPRGRRCSNYHVRF-----------------RCPLEASWGAWGPWGPCSGSCGPG 165
C N Q RGR C + + R R + W W PW CS +CG G
Sbjct: 395 CGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDG 454
Query: 166 RRLRRRHCPSPA----GDACPGRPLEAQKCVRPRCP 197
R R C SP+ G C G E + C + CP
Sbjct: 455 VITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Score = 41.2 bits (95), Expect = 0.006
Identities = 24/78 (30%), Positives = 30/78 (38%), Gaps = 11/78 (14%)
Query: 123 CLNREQPRGRRCSNYHVRFRC----PLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAG 178
C N P G C RC + W W W CS SCG G + R R C S
Sbjct: 358 CSNATVPDGECCP------RCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDS-LN 410
Query: 179 DACPGRPLEAQKCVRPRC 196
+ C G ++ + C C
Sbjct: 411 NRCEGSSVQTRTCHIQEC 428
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 56.6 bits (135), Expect = 1e-07
Identities = 43/142 (30%), Positives = 55/142 (38%), Gaps = 11/142 (7%)
Query: 65 VDHPGGDGDFESLAAIRFYYGP-ARVCPR--PLALEARTTDWALPSAVGERVHLNPTRGF 121
V PG D D + + F GP +R CP+ P + A+ + H G
Sbjct: 436 VTFPGKDYDADRQCQLTF--GPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGT 493
Query: 122 WCLNREQPRGRRCSNYHVR--FRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP--- 176
C + G RC + F P WG WGPWG CS +CG G + R C P
Sbjct: 494 PCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPR 553
Query: 177 -AGDACPGRPLEAQKCVRPRCP 197
G C GR + C CP
Sbjct: 554 NGGKYCEGRRTRFRSCNTEDCP 575
>gi|13489095 sialoadhesin precursor [Homo sapiens]
Length = 1709
Score = 56.6 bits (135), Expect = 1e-07
Identities = 70/218 (32%), Positives = 92/218 (42%), Gaps = 35/218 (16%)
Query: 256 RANIRAQMDGFSAGEAQAQANGSISVVTIILD-KLEKPYLVKHPESRVREAGQNVTFCCK 314
R IR ++ +GE + A S+ T LD L+ P + V E GQ VT C+
Sbjct: 475 RLEIR-DLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE-GQAVTLSCR 532
Query: 315 ASGTPMPK-KYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCKAWN-EAGAVRSGT 372
+ +P P ++SW+ NG LL G G+ L L AG YHC+A + + + S
Sbjct: 533 SGLSPTPDARFSWYLNGALLHE---GPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSP 589
Query: 373 ARLTVLAPGQPACDPRPREYLIKLPEDCGQPGSG-------------PAYLDVGLCPD-- 417
A LTVL P PR + +L D G+G PA L + L D
Sbjct: 590 AVLTVLYP------PRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL-LHKDRV 642
Query: 418 --TRCPSLAGSSPRCGDASSR--CCSVRRLERREIHCP 451
T PS G S CG S R L R EIH P
Sbjct: 643 VATSLPSGGGCS-TCGGCSPRMKVTKAPNLLRVEIHNP 679
Score = 48.1 bits (113), Expect = 5e-05
Identities = 55/212 (25%), Positives = 79/212 (37%), Gaps = 24/212 (11%)
Query: 183 GRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTPSGQPLLGARVSLRDQPGTVATSDA 242
G P A + RP +LD P ++ L ++ G L ++ +P
Sbjct: 1152 GPPGRAPRLSRP----ITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSH 1207
Query: 243 HGTFRVPGVCADSRANIRAQM-------DGF---SAGEAQAQANGSISVVTIILDKLEKP 292
G A +R ++ +GF SA QAN S+ + +LE
Sbjct: 1208 AGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLEL------RLEGV 1261
Query: 293 YLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPD 352
++ PE+ V E G +T C P Y+W+HNG L G A L
Sbjct: 1262 RVILAPEAAVPE-GAPITVTCADPAAHAPTLYTWYHNGRWLQ---EGPAASLSFLVATRA 1317
Query: 353 QAGIYHCKAWNEAGAVRSGTARLTVLAPGQPA 384
AG Y C+A + G S A L VL Q A
Sbjct: 1318 HAGAYSCQAQDAQGTRSSRPAALQVLYAPQDA 1349
Score = 41.6 bits (96), Expect = 0.004
Identities = 48/165 (29%), Positives = 66/165 (40%), Gaps = 17/165 (10%)
Query: 226 ARVSLRDQPGTVATSDA-HGTFRVPGVCADSRANIRAQMDGFSAGE-----AQAQANGSI 279
A ++L +ATS H G +R +R Q+ AG+ GSI
Sbjct: 1375 AELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSI 1434
Query: 280 SVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMP---KKYSWFHNGTLLDRR 336
S + + ++E +V P V E G + C+ G P P ++WF N DRR
Sbjct: 1435 STIGRL--QVEGARVVAEPGLDVPE-GAALNLSCRLLGGPGPVGNSTFAWFWN----DRR 1487
Query: 337 AHGYGAH-LELRGLRPDQAGIYHCKAWNEAGAVRSGTARLTVLAP 380
H L + QAG+YHC A GA S L VL P
Sbjct: 1488 LHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP 1532
Score = 40.4 bits (93), Expect = 0.010
Identities = 26/76 (34%), Positives = 32/76 (42%), Gaps = 6/76 (7%)
Query: 307 QNVTFCCKASG-TPMPKKYSWFHNGTLL-DRRAHGYGAHLELRGLRPDQAGIYHCKAWNE 364
Q VT C P +YSW+ N LL D +H HL R G Y C+ N
Sbjct: 340 QTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA----DTGFYFCEVQNV 395
Query: 365 AGAVRSGTARLTVLAP 380
G+ RSG + V P
Sbjct: 396 HGSERSGPVSVVVNHP 411
Score = 39.3 bits (90), Expect = 0.022
Identities = 42/175 (24%), Positives = 65/175 (37%), Gaps = 16/175 (9%)
Query: 242 AHGTFRVPGVCADSRANIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPESR 301
+HG F+ + +R G S N S T + ++ ++ P
Sbjct: 846 SHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE 905
Query: 302 VREAGQNVTFCCKA-SGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCK 360
++E GQ V C+ +G P Y W+ +G L A L + QAG YHC+
Sbjct: 906 LQE-GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST---SATLRFAAITLTQAGAYHCQ 961
Query: 361 AWNEAGAVRSGTARLTVLAPGQPACDPRPREYLIKLPEDCGQPGSGPAYLDVGLC 415
A G+A ++ AP PR + D +GP L + LC
Sbjct: 962 ------AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMD-----TGPGRLGLLLC 1005
Score = 36.2 bits (82), Expect = 0.19
Identities = 26/83 (31%), Positives = 33/83 (39%), Gaps = 5/83 (6%)
Query: 300 SRVREAGQNVTFCCKAS--GTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIY 357
S + G C S P +SWF NG L A G + L + A +Y
Sbjct: 716 SHTLQEGTEANLTCNVSREAAGSPANFSWFRNGVLW---AQGPLETVTLLPVARTDAALY 772
Query: 358 HCKAWNEAGAVRSGTARLTVLAP 380
C+ EAGA S L+VL P
Sbjct: 773 ACRILTEAGAQLSTPVLLSVLYP 795
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 56.2 bits (134), Expect = 2e-07
Identities = 23/57 (40%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 145 LEASWGAWGPWGPCSGSCGPGRRLRRRHC----PSPAGDACPGRPLEAQKCVRPRCP 197
++ W WG W CS +CG G R R+R C P P G CPG +E C CP
Sbjct: 542 VDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCP 598
Score = 40.8 bits (94), Expect = 0.008
Identities = 28/82 (34%), Positives = 36/82 (43%), Gaps = 17/82 (20%)
Query: 125 NREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDA---- 180
+R +P+ RRC N H P ++ W A GPW PCS +C G + R C +
Sbjct: 847 SRPEPQVRRC-NLH-----PCQSRWVA-GPWSPCSATCEKGFQHREVTCVYQLQNGTHVA 899
Query: 181 -----CPG-RPLEAQKCVRPRC 196
CPG RP Q C C
Sbjct: 900 TRPLYCPGPRPAAVQSCEGQDC 921
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 56.2 bits (134), Expect = 2e-07
Identities = 31/94 (32%), Positives = 38/94 (40%), Gaps = 12/94 (12%)
Query: 122 WCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHC----PSPA 177
WC RG +C Y P W W W PCS +CG G R R C PS
Sbjct: 568 WC------RGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHG 621
Query: 178 GDACPGRPLEAQKCVRPRCPGCSLD--TCECPDH 209
G C G + C +CP S+D +C +H
Sbjct: 622 GKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEH 655
Score = 33.5 bits (75), Expect = 1.2
Identities = 24/66 (36%), Positives = 29/66 (43%), Gaps = 11/66 (16%)
Query: 144 PLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCSL-- 201
P SW A PW C+ SCG G + R C GRP A C+ + P SL
Sbjct: 1125 PSRGSWFA-SPWSQCTASCGGGVQTRSVQC------LAGGRP--ASGCLLHQKPSASLAC 1175
Query: 202 DTCECP 207
+T CP
Sbjct: 1176 NTHFCP 1181
Score = 33.1 bits (74), Expect = 1.6
Identities = 22/65 (33%), Positives = 27/65 (41%), Gaps = 14/65 (21%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHC----PSPAGDACPG-------RPLEAQKC 191
CP +W A GPW CS +CG G R R C PS P +P + C
Sbjct: 986 CP--PAWSA-GPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
Query: 192 VRPRC 196
+ RC
Sbjct: 1043 LLQRC 1047
Score = 31.2 bits (69), Expect = 6.0
Identities = 21/64 (32%), Positives = 23/64 (35%), Gaps = 12/64 (18%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHC---------PSPAGDACPGRPLEAQKCVR 193
CP SW G W CS +CG G + R C P PA P Q C
Sbjct: 927 CP--PSWSV-GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNS 983
Query: 194 PRCP 197
CP
Sbjct: 984 QSCP 987
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 55.8 bits (133), Expect = 2e-07
Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 9/116 (7%)
Query: 258 NIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPE---SRVREAGQNVTFCCK 314
NI +G E + +A G I II+ + P + P+ + E G+ +TF C+
Sbjct: 175 NINKSDEGIYRCEGRVEARGEIDFRDIIVI-VNVPPAISMPQKSFNATAERGEEMTFSCR 233
Query: 315 ASGTPMPKKYSWFHNGTLLDRR----AHGYGAHLELRGLRPDQAGIYHCKAWNEAG 366
ASG+P P SWF NG L++ G L +R + G Y C+A N+AG
Sbjct: 234 ASGSPEP-AISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAG 288
Score = 32.3 bits (72), Expect = 2.7
Identities = 28/111 (25%), Positives = 46/111 (41%), Gaps = 22/111 (19%)
Query: 268 AGEAQAQANGSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPK----- 322
AGE + QA L +P++++ E GQ VT C A G P+P+
Sbjct: 287 AGEDEKQA---------FLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKR 336
Query: 323 ---KYSWFHNGTLLDRRAHGYGAH----LELRGLRPDQAGIYHCKAWNEAG 366
+++ LD R G H L ++ ++ +G Y C+A + G
Sbjct: 337 AVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIG 387
Score = 32.0 bits (71), Expect = 3.5
Identities = 23/95 (24%), Positives = 41/95 (43%), Gaps = 4/95 (4%)
Query: 275 ANGSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHN---GT 331
A G T++L+ +K + + + G++ C+ S +P P +HN T
Sbjct: 98 AKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTT 157
Query: 332 LLDRR-AHGYGAHLELRGLRPDQAGIYHCKAWNEA 365
+ D R A +L++ + GIY C+ EA
Sbjct: 158 ISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEA 192
>gi|8923894 thrombospondin type I domain-containing 1 isoform 1
[Homo sapiens]
Length = 852
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/51 (47%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Query: 148 SWGAWGPWGPCSGSCGPGRRLRRRHCPS--PAGDACPGRPLEAQKCVRPRC 196
+WG W PW CS +CG G R RRR C + P+ CPG LEA C C
Sbjct: 342 TWGLWQPWSQCSATCGDGVRERRRVCLTSFPSSPVCPGMSLEASLCSLEEC 392
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 54.7 bits (130), Expect = 5e-07
Identities = 41/140 (29%), Positives = 58/140 (41%), Gaps = 12/140 (8%)
Query: 66 DHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSAVGERV----HLNPTRGF 121
D PG + F G ++ CP ++ T W A G+ V H G
Sbjct: 436 DLPGASYTLSQQCELAFGVG-SKPCPY---MQYCTKLWCTGKAKGQMVCQTRHFPWADGT 491
Query: 122 WCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHC--PSPA-- 177
C + C H + ++ SW W P+GPCS +CG G +L RR C P+PA
Sbjct: 492 SCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANG 551
Query: 178 GDACPGRPLEAQKCVRPRCP 197
G C G ++ + C CP
Sbjct: 552 GKYCEGVRVKYRSCNLEPCP 571
Score = 45.1 bits (105), Expect = 4e-04
Identities = 27/57 (47%), Positives = 29/57 (50%), Gaps = 8/57 (14%)
Query: 147 ASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGD----ACPG--RPLEAQKCVRPRCP 197
A W A G WGPCS SCG G + R C AG AC RP+E Q C P CP
Sbjct: 841 ARWVA-GSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEP-CP 895
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 54.3 bits (129), Expect = 7e-07
Identities = 33/104 (31%), Positives = 42/104 (40%), Gaps = 13/104 (12%)
Query: 104 ALPSAVGERVHLNPTRGFWCLNRE-QPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSC 162
++P+A G + WC R P G R ++ +WG W PWG CS +C
Sbjct: 512 SIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEG--------VDGAWGPWTPWGDCSRTC 563
Query: 163 GPGRRLRRRHCPSP----AGDACPGRPLEAQKCVRPRCPGCSLD 202
G G RHC SP G C G + C CP S D
Sbjct: 564 GGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQD 607
Score = 40.0 bits (92), Expect = 0.013
Identities = 28/73 (38%), Positives = 33/73 (45%), Gaps = 12/73 (16%)
Query: 142 RCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPG-----RPLEAQKCVRPRC 196
RCP A W A G WG CS CG G+R R C S G A RP Q+C +C
Sbjct: 1001 RCP-PARWVA-GEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQC-EAKC 1057
Query: 197 ----PGCSLDTCE 205
PG + C+
Sbjct: 1058 DSPTPGDGPEECK 1070
Score = 34.3 bits (77), Expect = 0.70
Identities = 23/63 (36%), Positives = 27/63 (42%), Gaps = 11/63 (17%)
Query: 143 CPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPS--------PAGDACPGRPLEAQKCVRP 194
CP E W A W C+ SCGPG R R C S PA + +P +C
Sbjct: 944 CPPE--WAALD-WSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLR 1000
Query: 195 RCP 197
RCP
Sbjct: 1001 RCP 1003
Score = 33.9 bits (76), Expect = 0.92
Identities = 36/114 (31%), Positives = 43/114 (37%), Gaps = 10/114 (8%)
Query: 153 GPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCP---GCSLDTCECPDH 209
G W CS SC G R R C A + L+ C +PR P C TC
Sbjct: 891 GNWSLCSRSCDAGVRSRSVVCQRRV-SAAEEKALDDSACPQPRPPVLEACHGPTCPPEWA 949
Query: 210 ILLGSVVTPSGQPLLGARVSL---RDQPGTVATSDAHGTFRVPGVCADSRANIR 260
L S TPS P L RV L D T+ + + P A R N+R
Sbjct: 950 ALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPP---ATMRCNLR 1000
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 53.9 bits (128), Expect = 9e-07
Identities = 30/85 (35%), Positives = 38/85 (44%), Gaps = 9/85 (10%)
Query: 122 WCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----A 177
WC +GR S + + W +WGP PCS SCG G RRR C +P
Sbjct: 334 WC-----SKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG 388
Query: 178 GDACPGRPLEAQKCVRPRCPGCSLD 202
G AC G L+A+ C C L+
Sbjct: 389 GRACVGADLQAEMCNTQACEKTQLE 413
Score = 35.4 bits (80), Expect = 0.32
Identities = 25/70 (35%), Positives = 30/70 (42%), Gaps = 6/70 (8%)
Query: 143 CPLEASWGAW--GPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCS 200
C LE W G +GPCS SCG G R R C G P A+ + P +
Sbjct: 706 CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLP-PARCRAGAQQPAVA 764
Query: 201 LDTCE---CP 207
L+TC CP
Sbjct: 765 LETCNPQPCP 774
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 53.9 bits (128), Expect = 9e-07
Identities = 30/85 (35%), Positives = 38/85 (44%), Gaps = 9/85 (10%)
Query: 122 WCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----A 177
WC +GR S + + W +WGP PCS SCG G RRR C +P
Sbjct: 365 WC-----SKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG 419
Query: 178 GDACPGRPLEAQKCVRPRCPGCSLD 202
G AC G L+A+ C C L+
Sbjct: 420 GRACVGADLQAEMCNTQACEKTQLE 444
Score = 35.4 bits (80), Expect = 0.32
Identities = 25/70 (35%), Positives = 30/70 (42%), Gaps = 6/70 (8%)
Query: 143 CPLEASWGAW--GPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCS 200
C LE W G +GPCS SCG G R R C G P A+ + P +
Sbjct: 737 CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLP-PARCRAGAQQPAVA 795
Query: 201 LDTCE---CP 207
L+TC CP
Sbjct: 796 LETCNPQPCP 805
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 53.9 bits (128), Expect = 9e-07
Identities = 30/85 (35%), Positives = 38/85 (44%), Gaps = 9/85 (10%)
Query: 122 WCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSP----A 177
WC +GR S + + W +WGP PCS SCG G RRR C +P
Sbjct: 365 WC-----SKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG 419
Query: 178 GDACPGRPLEAQKCVRPRCPGCSLD 202
G AC G L+A+ C C L+
Sbjct: 420 GRACVGADLQAEMCNTQACEKTQLE 444
Score = 35.4 bits (80), Expect = 0.32
Identities = 25/70 (35%), Positives = 30/70 (42%), Gaps = 6/70 (8%)
Query: 143 CPLEASWGAW--GPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCS 200
C LE W G +GPCS SCG G R R C G P A+ + P +
Sbjct: 737 CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLP-PARCRAGAQQPAVA 795
Query: 201 LDTCE---CP 207
L+TC CP
Sbjct: 796 LETCNPQPCP 805
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 52.8 bits (125), Expect = 2e-06
Identities = 23/54 (42%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 148 SWGAWGPWGPCSGSCGPGRRLRRRHCPSPA----GDACPGRPLEAQKCVRPRCP 197
+WG+WG WG CS SCG G + RHC +PA G C G+ + C CP
Sbjct: 569 NWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 52.8 bits (125), Expect = 2e-06
Identities = 33/100 (33%), Positives = 44/100 (44%), Gaps = 17/100 (17%)
Query: 116 NPTRGFWCLNREQPR--------GRRCSNYHVRFRCP-----LEASWGAWGPWGPCSGSC 162
+P ++C ++ P G+ C H ++ P + W +W +G CS SC
Sbjct: 509 HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSC 568
Query: 163 GPGRRLRRRHC--PSPA--GDACPGRPLEAQKCVRPRCPG 198
G G R R R C PSPA G C G E Q C CPG
Sbjct: 569 GGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPG 608
Score = 38.9 bits (89), Expect = 0.029
Identities = 33/98 (33%), Positives = 43/98 (43%), Gaps = 12/98 (12%)
Query: 127 EQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDA--CPG- 183
++P RR +R CP + GA W CS +CG G + R+ C + A C G
Sbjct: 955 DRPEARRPC---LRVPCPAQWRLGA---WSQCSATCGEGIQQRQVVCRTNANSLGHCEGD 1008
Query: 184 RPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTPSGQ 221
RP Q C P C G ++ D LG TP GQ
Sbjct: 1009 RPDTVQVCSLPACGGNHQNSTVRADVWELG---TPEGQ 1043
Score = 32.7 bits (73), Expect = 2.0
Identities = 26/83 (31%), Positives = 33/83 (39%), Gaps = 17/83 (20%)
Query: 126 REQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGP-GRRLRRRHCPSPAGD----- 179
R +P RRC+ + P WG CS SCG G + R C P +
Sbjct: 893 RPKPIRRRCNQH------PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKV 946
Query: 180 ----ACPG-RPLEAQKCVRPRCP 197
AC G RP + C+R CP
Sbjct: 947 MPAKACAGDRPEARRPCLRVPCP 969
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,994,744
Number of Sequences: 37866
Number of extensions: 3006881
Number of successful extensions: 9232
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 248
Number of HSP's that attempted gapping in prelim test: 7815
Number of HSP's gapped (non-prelim): 1401
length of query: 1156
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1043
effective length of database: 13,968,660
effective search space: 14569312380
effective search space used: 14569312380
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.