Guide to the Human Genome
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Search of human proteins with 14550405

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14550405 postreplication repair protein hRAD18p [Homo
sapiens]
         (495 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14550405 postreplication repair protein hRAD18p [Homo sapiens]     983   0.0  
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             53   6e-07
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap...    52   2e-06
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap...    52   2e-06
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    51   3e-06
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]             50   5e-06
gi|109240538 polycomb group ring finger 1 [Homo sapiens]               50   5e-06
gi|19923717 deltex 3-like [Homo sapiens]                               49   1e-05
gi|52487176 tripartite motif-containing 37 protein [Homo sapiens]      47   3e-05
gi|15147333 tripartite motif-containing 37 protein [Homo sapiens]      47   3e-05
gi|31542779 tripartite motif family-like 1 [Homo sapiens]              47   4e-05
gi|4504867 ring finger protein 8 isoform 1 [Homo sapiens]              47   5e-05
gi|6005964 ring finger protein 110 [Homo sapiens]                      46   7e-05
gi|27883842 BMI1 polycomb ring finger oncogene [Homo sapiens]          45   2e-04
gi|21314654 ring finger protein 139 [Homo sapiens]                     45   2e-04
gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]    45   2e-04
gi|33946313 ninein isoform 4 [Homo sapiens]                            44   3e-04
gi|33946321 ninein isoform 5 [Homo sapiens]                            44   3e-04
gi|148536871 ninein isoform 1 [Homo sapiens]                           44   3e-04
gi|148536869 ninein isoform 2 [Homo sapiens]                           44   3e-04
gi|237681119 breast cancer 1, early onset isoform 2 [Homo sapiens]     44   3e-04
gi|237681125 breast cancer 1, early onset isoform 5 [Homo sapiens]     44   3e-04
gi|237681123 breast cancer 1, early onset isoform 4 [Homo sapiens]     44   3e-04
gi|6552299 breast cancer 1, early onset isoform 1 [Homo sapiens]       44   3e-04
gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]    44   3e-04
gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]    44   3e-04
gi|7705415 hook homolog 1 [Homo sapiens]                               44   3e-04
gi|58761530 polycomb group ring finger 6 isoform a [Homo sapiens]      44   3e-04
gi|94536782 tripartite motif-containing 35 isoform 2 [Homo sapiens]    44   3e-04
gi|223890259 midline 2 isoform 2 [Homo sapiens]                        44   4e-04

>gi|14550405 postreplication repair protein hRAD18p [Homo sapiens]
          Length = 495

 Score =  983 bits (2542), Expect = 0.0
 Identities = 495/495 (100%), Positives = 495/495 (100%)

Query: 1   MDSLAESRWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQC 60
           MDSLAESRWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQC
Sbjct: 1   MDSLAESRWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQC 60

Query: 61  PTCCVTVTEPDLKNNRILDELVKSLNFARNHLLQFALESPAKSPASSSSKNLAVKVYTPV 120
           PTCCVTVTEPDLKNNRILDELVKSLNFARNHLLQFALESPAKSPASSSSKNLAVKVYTPV
Sbjct: 61  PTCCVTVTEPDLKNNRILDELVKSLNFARNHLLQFALESPAKSPASSSSKNLAVKVYTPV 120

Query: 121 ASRQSLKQGSRLMDNFLIREMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAP 180
           ASRQSLKQGSRLMDNFLIREMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAP
Sbjct: 121 ASRQSLKQGSRLMDNFLIREMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAP 180

Query: 181 DPSEAKRPEPPSTSTLKQVTKVDCPVCGVNIPESHINKHLDSCLSREEKKESLRSSVHKR 240
           DPSEAKRPEPPSTSTLKQVTKVDCPVCGVNIPESHINKHLDSCLSREEKKESLRSSVHKR
Sbjct: 181 DPSEAKRPEPPSTSTLKQVTKVDCPVCGVNIPESHINKHLDSCLSREEKKESLRSSVHKR 240

Query: 241 KPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEI 300
           KPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEI
Sbjct: 241 KPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEI 300

Query: 301 VQEIENIEKTRMRLEASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQLLVDQARKG 360
           VQEIENIEKTRMRLEASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQLLVDQARKG
Sbjct: 301 VQEIENIEKTRMRLEASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQLLVDQARKG 360

Query: 361 YKKIAGMSQKTVTITKEDESTEKLSSVCMGQEDNMTSVTNHFSQSKLDSPEELEPDREED 420
           YKKIAGMSQKTVTITKEDESTEKLSSVCMGQEDNMTSVTNHFSQSKLDSPEELEPDREED
Sbjct: 361 YKKIAGMSQKTVTITKEDESTEKLSSVCMGQEDNMTSVTNHFSQSKLDSPEELEPDREED 420

Query: 421 SSSCIDIQEVLSSSESDSCNSSSSDIIRDLLEEEEAWEASHKNDLQDTEISPRQNRRTRA 480
           SSSCIDIQEVLSSSESDSCNSSSSDIIRDLLEEEEAWEASHKNDLQDTEISPRQNRRTRA
Sbjct: 421 SSSCIDIQEVLSSSESDSCNSSSSDIIRDLLEEEEAWEASHKNDLQDTEISPRQNRRTRA 480

Query: 481 AESAEIEPRNKRNRN 495
           AESAEIEPRNKRNRN
Sbjct: 481 AESAEIEPRNKRNRN 495


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 76/369 (20%), Positives = 159/369 (43%), Gaps = 53/369 (14%)

Query: 135 NFLIREMSGSTSELLIK-ENKSKFSPQKEASPAAKTKETRSVEEIAPDPSEAKRPEPPST 193
           N  + E     S+L I+ + K++     EA+  A+  + ++  + A +  + K+ E    
Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686

Query: 194 ST-LKQVT-KVDCPVCGVNIPESHINKHLDSCLSREEKKESLRSSVHKRKPLPKTVYNLL 251
           +T L QVT K+       +  ESH+ ++ +  LS E+K E L   +              
Sbjct: 687 TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI-------------- 732

Query: 252 SDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEIVQEIENIEKTR 311
                 KKL+   L ++ +K+Q ++  Q+     N   +    + + ++  E E +  TR
Sbjct: 733 ------KKLEADSLEVKASKEQALQDLQQ-QRQLNTDLELRATELSKQLEMEKEIVSSTR 785

Query: 312 MRLE-ASKLNESV-MVFTKDQTEKEIDEIHSKYRKKHKSEFQLLVDQARKGYKKIAGMSQ 369
           + L+  S+  ES+    TK + EK+I           K +F+ L  + +  ++++    Q
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQI----------LKQDFETLSQETKIQHEELNNRIQ 835

Query: 370 KTVT-ITKEDESTEKLSSVCMGQEDNMTSVTNHFSQSKLDSPEELEPDREEDSSSCIDIQ 428
            TVT + K     E L +     +D ++ V++    SK     E E + ++  ++ +D++
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK----SEFEKENQKGKAAILDLE 891

Query: 429 EVLSSSESDSCNSSSSDI-----IRDLLEEEEAWEASHK-----NDLQDTEISPRQNRRT 478
           +     +        + +     ++  LE+E+  EASH+     N +Q+  I  +   + 
Sbjct: 892 KTCKELKHQLQVQMENTLKEQKELKKSLEKEK--EASHQLKLELNSMQEQLIQAQNTLKQ 949

Query: 479 RAAESAEIE 487
              E  +++
Sbjct: 950 NEKEEQQLQ 958



 Score = 33.1 bits (74), Expect = 0.60
 Identities = 63/279 (22%), Positives = 113/279 (40%), Gaps = 55/279 (19%)

Query: 121 ASRQSLKQG--SRLMDNFLIREMSGSTSELL------IKENKSKFSPQKEASPAAKTKET 172
           A  QSL+Q       +NF I++M     +        I + KSK+  ++    AA+ K T
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194

Query: 173 RSVEEIAPDPSE--------AKRPEPPSTSTL-KQVTKVDCPVCGVNIP-ESHINKHLDS 222
           R  EE+  + +          +RP     + L K++ +V   +  + +  E    K  D 
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254

Query: 223 C-------LSREEKKESLRSS-----------VHKRKPLPKTVYNL------LSDRDLKK 258
           C        S E     LRS            V + + L  +V  L      L++  LKK
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314

Query: 259 KLKEHGLSIQGNKQQLIKRH-QEFVHMYNAQCDALHPKSAAEIVQEIENIEKTRMRLEAS 317
           +     L  + N++ + K++ Q  +H  +  C  L  + +A            R+ +E S
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA------SETSLHRIHVELS 368

Query: 318 KLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQLLVDQ 356
           +  E+       + ++E+ E+ +KY+   K+EF+ L  Q
Sbjct: 369 EKGEAT-----QKLKEELSEVETKYQHL-KAEFKQLQQQ 401



 Score = 31.2 bits (69), Expect = 2.3
 Identities = 51/304 (16%), Positives = 139/304 (45%), Gaps = 51/304 (16%)

Query: 123 RQSLKQGSRLMDNFLI-REMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAPD 181
           ++ L Q   LMDN  + RE      +   K+ +S+++  +      +++  +  +E+A  
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286

Query: 182 PSEAKRPEPPSTSTLKQVTKVDCPVCGVNIPESHINKHLDSCLSREE------KKESLRS 235
             E ++ +    S++ ++T+ +       + E+ + K  D     E+       K+++++
Sbjct: 287 VQELQKLK----SSVNELTQKN-----QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA 337

Query: 236 SVHKRKPLPKTVYNLLSDRD-----LKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCD 290
           ++H++    + + + LS  +     +  +L E G + Q  K++L +   ++ H+      
Sbjct: 338 TLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL------ 391

Query: 291 ALHPKSAAEIVQEIENIEKTRMRL--EASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKS 348
                   ++ Q+ E  E+  ++L  E ++L+  ++     +TE+++ E H + +++ + 
Sbjct: 392 ---KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLL-----ETERQLGEAHGRLKEQRQL 443

Query: 349 EFQLLVDQARKGYKKIAGMSQKTVTITKEDESTEKLSSVCMGQEDNMTSVTNHFSQSKLD 408
             + L+D+     +++A +  K   +  E++  EK++        N T + +   ++K  
Sbjct: 444 SSEKLMDKE----QQVADLQLKLSRL--EEQLKEKVT--------NSTELQHQLDKTKQQ 489

Query: 409 SPEE 412
             E+
Sbjct: 490 HQEQ 493


>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo
           sapiens]
          Length = 1758

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 45/181 (24%), Positives = 70/181 (38%), Gaps = 20/181 (11%)

Query: 19  IDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFL--SYKTQCPTCCVTVTEPD-LKNN 75
           I D L C IC +    A++IP C ++YC  CIR  L  S +  CPTC      PD L  N
Sbjct: 253 IPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIAN 312

Query: 76  RILDELVKSLNFARNHLLQFALESPAKSPASSSSKNLAVKVYTPVASRQSLKQGSRLMDN 135
           + L + V +      +  +   + P   P     + L  +   P+      +Q   LM  
Sbjct: 313 KFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIP 372

Query: 136 FLIREMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAPDPSEAKRPEPPSTST 195
                   + S   +  N+S  +P                  ++ +PS A  P P  T+T
Sbjct: 373 VTSSSTHPAPSISSLTSNQSSLAP-----------------PVSGNPSSAPAPVPDITAT 415

Query: 196 L 196
           +
Sbjct: 416 V 416


>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo
           sapiens]
          Length = 1792

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 45/181 (24%), Positives = 70/181 (38%), Gaps = 20/181 (11%)

Query: 19  IDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFL--SYKTQCPTCCVTVTEPD-LKNN 75
           I D L C IC +    A++IP C ++YC  CIR  L  S +  CPTC      PD L  N
Sbjct: 253 IPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIAN 312

Query: 76  RILDELVKSLNFARNHLLQFALESPAKSPASSSSKNLAVKVYTPVASRQSLKQGSRLMDN 135
           + L + V +      +  +   + P   P     + L  +   P+      +Q   LM  
Sbjct: 313 KFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIP 372

Query: 136 FLIREMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAPDPSEAKRPEPPSTST 195
                   + S   +  N+S  +P                  ++ +PS A  P P  T+T
Sbjct: 373 VTSSSTHPAPSISSLTSNQSSLAP-----------------PVSGNPSSAPAPVPDITAT 415

Query: 196 L 196
           +
Sbjct: 416 V 416


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 48/214 (22%), Positives = 92/214 (42%), Gaps = 29/214 (13%)

Query: 255  DLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEIVQEIENIEKTRMRL 314
            +L KK +   L ++ + ++   +H+  V    A     H  S AE+ ++I+N+++ + +L
Sbjct: 1163 ELNKKREAEFLKLRRDLEEATLQHEAMV----AALRKKHADSVAELGEQIDNLQRVKQKL 1218

Query: 315  EASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQL------LVDQARKGYKKIAGMS 368
            E            K + + EID++ S      KS+  L      L DQ  +   K   + 
Sbjct: 1219 EKE----------KSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ 1268

Query: 369  QKTVTITKEDESTEKLSSVCMGQEDNMTSVTNHFSQSK---LDSPEELEPDREEDSSSCI 425
            +    +T +    +  +     Q +   S+ +  S+SK       EEL+   EE++ +  
Sbjct: 1269 RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKN 1328

Query: 426  DIQEVLSSSESDSCNSSSSDIIRDLLEEEEAWEA 459
             +   L SS  D       D++R+  EEE+  +A
Sbjct: 1329 ALAHALQSSRHD------CDLLREQYEEEQEGKA 1356


>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
          Length = 777

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 27/92 (29%), Positives = 40/92 (43%), Gaps = 2/92 (2%)

Query: 1   MDSLAESRWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQC 60
           M+      W    A +  ++ LLRC  C       + +  C H +CS C+   +   T C
Sbjct: 26  MEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIG--TGC 83

Query: 61  PTCCVTVTEPDLKNNRILDELVKSLNFARNHL 92
           P C       DLK NR LD +++  +  RN L
Sbjct: 84  PVCYTPAWIQDLKINRQLDSMIQLCSKLRNLL 115


>gi|109240538 polycomb group ring finger 1 [Homo sapiens]
          Length = 259

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 24/74 (32%), Positives = 42/74 (56%), Gaps = 4/74 (5%)

Query: 16  MKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTV--TEP--D 71
           +K +++ + C +C  YF  A  I +C H +C  CI K+L     CP C + +  T+P  +
Sbjct: 38  IKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLN 97

Query: 72  LKNNRILDELVKSL 85
           LK +R++ ++V  L
Sbjct: 98  LKLDRVMQDIVYKL 111


>gi|19923717 deltex 3-like [Homo sapiens]
          Length = 740

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 17/39 (43%), Positives = 25/39 (64%)

Query: 25  CGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTC 63
           C IC +  +   ++P+C H +C+ CI K +SYK  CPTC
Sbjct: 561 CVICMDTISNKKVLPKCKHEFCAPCINKAMSYKPICPTC 599


>gi|52487176 tripartite motif-containing 37 protein [Homo sapiens]
          Length = 964

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 24/72 (33%), Positives = 40/72 (55%), Gaps = 1/72 (1%)

Query: 16 MKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLS-YKTQCPTCCVTVTEPDLKN 74
          +++I ++ RC IC E    A + P CS   C  CIR++L+  + QCP C   +   +L N
Sbjct: 6  VESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVN 65

Query: 75 NRILDELVKSLN 86
           R  +E+ + L+
Sbjct: 66 CRWAEEVTQQLD 77


>gi|15147333 tripartite motif-containing 37 protein [Homo sapiens]
          Length = 964

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 24/72 (33%), Positives = 40/72 (55%), Gaps = 1/72 (1%)

Query: 16 MKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLS-YKTQCPTCCVTVTEPDLKN 74
          +++I ++ RC IC E    A + P CS   C  CIR++L+  + QCP C   +   +L N
Sbjct: 6  VESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVN 65

Query: 75 NRILDELVKSLN 86
           R  +E+ + L+
Sbjct: 66 CRWAEEVTQQLD 77


>gi|31542779 tripartite motif family-like 1 [Homo sapiens]
          Length = 468

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 27/102 (26%), Positives = 52/102 (50%), Gaps = 4/102 (3%)

Query: 15  VMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLC-IRKFLSYKT--QCPTCCVTVTEPD 71
           +M+ + + L C IC +YF+ + +  +C H++C +C +R +  + T   CP C  T+  P 
Sbjct: 6   LMENLREELTCFICLDYFS-SPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTLEGPH 64

Query: 72  LKNNRILDELVKSLNFARNHLLQFALESPAKSPASSSSKNLA 113
            ++N  L  L       R+ +LQ   E  +     +++K L+
Sbjct: 65  FQSNERLGRLASIARQLRSQVLQSEDEQGSYGRMPTTAKALS 106


>gi|4504867 ring finger protein 8 isoform 1 [Homo sapiens]
          Length = 485

 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 18/45 (40%), Positives = 30/45 (66%), Gaps = 1/45 (2%)

Query: 19  IDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTC 63
           +++ L+C IC EYF I  +   C+H++CS CI +++  K +CP C
Sbjct: 397 LENELQCIICSEYF-IEAVTLNCAHSFCSYCINEWMKRKIECPIC 440


>gi|6005964 ring finger protein 110 [Homo sapiens]
          Length = 344

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 23/67 (34%), Positives = 36/67 (53%), Gaps = 4/67 (5%)

Query: 23 LRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTV--TEP--DLKNNRIL 78
          L C +C  YF  A  I +C H++C  CI ++L     CP C V V  T P   +++++ L
Sbjct: 16 LMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTL 75

Query: 79 DELVKSL 85
           ++V  L
Sbjct: 76 QDIVYKL 82


>gi|27883842 BMI1 polycomb ring finger oncogene [Homo sapiens]
          Length = 326

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 23/67 (34%), Positives = 37/67 (55%), Gaps = 4/67 (5%)

Query: 23 LRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTV--TEP--DLKNNRIL 78
          L C +C  YF  A  I +C H++C  CI ++L     CP C V V  T P  ++++++ L
Sbjct: 16 LMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDKTL 75

Query: 79 DELVKSL 85
           ++V  L
Sbjct: 76 QDIVYKL 82


>gi|21314654 ring finger protein 139 [Homo sapiens]
          Length = 664

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 22/61 (36%), Positives = 36/61 (59%), Gaps = 3/61 (4%)

Query: 16  MKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTV-TEPDLKN 74
           ++ I+D+  C IC+  F  +  I  C+H + +LC+RK+L  +  CP C   V  E D+K+
Sbjct: 540 LQEINDV--CAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKD 597

Query: 75  N 75
           N
Sbjct: 598 N 598


>gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]
          Length = 500

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 4/78 (5%)

Query: 11  PGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKF---LSYKTQCPTCCVTV 67
           P   V++ I   L C +C ++F   +++  C HN+C  CI+ F    + +T CP C +  
Sbjct: 27  PSKVVIQDITMELHCPLCNDWFRDPLML-SCGHNFCEACIQDFWRLQAKETFCPECKMLC 85

Query: 68  TEPDLKNNRILDELVKSL 85
              +   N +LD+LV+ +
Sbjct: 86  QYNNCTFNPVLDKLVEKI 103


>gi|33946313 ninein isoform 4 [Homo sapiens]
          Length = 2096

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/271 (18%), Positives = 116/271 (42%), Gaps = 28/271 (10%)

Query: 219 HLDSCLSREEKKESLRSSVHKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKR- 277
           H ++    EE+K+ L+  + + K   +    L  + +LK +L +   S +  ++ L    
Sbjct: 696 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 755

Query: 278 -HQEFVHMYNAQCDALHPKSAAEIVQEIENIEKTRMRLEASKLNESVMVFTKDQTEKEID 336
             +E V     + +  H +    +V++   +EK  +R E  + ++  +   +++ E E +
Sbjct: 756 WTEEKVRGLTQELEQFHQEQLTSLVEK-HTLEKEELRKELLEKHQRELQEGREKMETECN 814

Query: 337 EIHSKYRKKHKSEFQLLVDQARKGYKKIAGMSQKTVTITKEDESTEK---------LSSV 387
              S+   + +S+ Q + ++     + + G  ++ +   +E +  EK         L+  
Sbjct: 815 RRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQE 874

Query: 388 CMGQEDNMTSVTNHFSQSKLDSPEELE----PDREEDSSSCIDIQEVLSSSE-----SDS 438
           C   ++ +         + L   +E E      +E  +S  ++ Q++L   E     S++
Sbjct: 875 CAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 934

Query: 439 CNSSSSDIIRDLLEEEEAWEASHKNDLQDTE 469
             S  SD I +L       ++SHK +L++ E
Sbjct: 935 QQSLLSDQILEL-------KSSHKRELRERE 958


>gi|33946321 ninein isoform 5 [Homo sapiens]
          Length = 2090

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/271 (18%), Positives = 116/271 (42%), Gaps = 28/271 (10%)

Query: 219 HLDSCLSREEKKESLRSSVHKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKR- 277
           H ++    EE+K+ L+  + + K   +    L  + +LK +L +   S +  ++ L    
Sbjct: 690 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749

Query: 278 -HQEFVHMYNAQCDALHPKSAAEIVQEIENIEKTRMRLEASKLNESVMVFTKDQTEKEID 336
             +E V     + +  H +    +V++   +EK  +R E  + ++  +   +++ E E +
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEK-HTLEKEELRKELLEKHQRELQEGREKMETECN 808

Query: 337 EIHSKYRKKHKSEFQLLVDQARKGYKKIAGMSQKTVTITKEDESTEK---------LSSV 387
              S+   + +S+ Q + ++     + + G  ++ +   +E +  EK         L+  
Sbjct: 809 RRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQE 868

Query: 388 CMGQEDNMTSVTNHFSQSKLDSPEELE----PDREEDSSSCIDIQEVLSSSE-----SDS 438
           C   ++ +         + L   +E E      +E  +S  ++ Q++L   E     S++
Sbjct: 869 CAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 928

Query: 439 CNSSSSDIIRDLLEEEEAWEASHKNDLQDTE 469
             S  SD I +L       ++SHK +L++ E
Sbjct: 929 QQSLLSDQILEL-------KSSHKRELRERE 952


>gi|148536871 ninein isoform 1 [Homo sapiens]
          Length = 2046

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/271 (18%), Positives = 116/271 (42%), Gaps = 28/271 (10%)

Query: 219 HLDSCLSREEKKESLRSSVHKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKR- 277
           H ++    EE+K+ L+  + + K   +    L  + +LK +L +   S +  ++ L    
Sbjct: 690 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749

Query: 278 -HQEFVHMYNAQCDALHPKSAAEIVQEIENIEKTRMRLEASKLNESVMVFTKDQTEKEID 336
             +E V     + +  H +    +V++   +EK  +R E  + ++  +   +++ E E +
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEK-HTLEKEELRKELLEKHQRELQEGREKMETECN 808

Query: 337 EIHSKYRKKHKSEFQLLVDQARKGYKKIAGMSQKTVTITKEDESTEK---------LSSV 387
              S+   + +S+ Q + ++     + + G  ++ +   +E +  EK         L+  
Sbjct: 809 RRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQE 868

Query: 388 CMGQEDNMTSVTNHFSQSKLDSPEELE----PDREEDSSSCIDIQEVLSSSE-----SDS 438
           C   ++ +         + L   +E E      +E  +S  ++ Q++L   E     S++
Sbjct: 869 CAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 928

Query: 439 CNSSSSDIIRDLLEEEEAWEASHKNDLQDTE 469
             S  SD I +L       ++SHK +L++ E
Sbjct: 929 QQSLLSDQILEL-------KSSHKRELRERE 952


>gi|148536869 ninein isoform 2 [Homo sapiens]
          Length = 2133

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/271 (18%), Positives = 116/271 (42%), Gaps = 28/271 (10%)

Query: 219 HLDSCLSREEKKESLRSSVHKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKR- 277
           H ++    EE+K+ L+  + + K   +    L  + +LK +L +   S +  ++ L    
Sbjct: 690 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749

Query: 278 -HQEFVHMYNAQCDALHPKSAAEIVQEIENIEKTRMRLEASKLNESVMVFTKDQTEKEID 336
             +E V     + +  H +    +V++   +EK  +R E  + ++  +   +++ E E +
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEK-HTLEKEELRKELLEKHQRELQEGREKMETECN 808

Query: 337 EIHSKYRKKHKSEFQLLVDQARKGYKKIAGMSQKTVTITKEDESTEK---------LSSV 387
              S+   + +S+ Q + ++     + + G  ++ +   +E +  EK         L+  
Sbjct: 809 RRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQE 868

Query: 388 CMGQEDNMTSVTNHFSQSKLDSPEELE----PDREEDSSSCIDIQEVLSSSE-----SDS 438
           C   ++ +         + L   +E E      +E  +S  ++ Q++L   E     S++
Sbjct: 869 CAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 928

Query: 439 CNSSSSDIIRDLLEEEEAWEASHKNDLQDTE 469
             S  SD I +L       ++SHK +L++ E
Sbjct: 929 QQSLLSDQILEL-------KSSHKRELRERE 952


>gi|237681119 breast cancer 1, early onset isoform 2 [Homo
          sapiens]
          Length = 1884

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 4/74 (5%)

Query: 15 VMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYK---TQCPTCCVTVTEPD 71
          V+  +  +L C IC E      +  +C H +C  C+ K L+ K   +QCP C   +T+  
Sbjct: 14 VINAMQKILECPICLELIK-EPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRS 72

Query: 72 LKNNRILDELVKSL 85
          L+ +    +LV+ L
Sbjct: 73 LQESTRFSQLVEEL 86


>gi|237681125 breast cancer 1, early onset isoform 5 [Homo
          sapiens]
          Length = 699

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 4/74 (5%)

Query: 15 VMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYK---TQCPTCCVTVTEPD 71
          V+  +  +L C IC E      +  +C H +C  C+ K L+ K   +QCP C   +T+  
Sbjct: 14 VINAMQKILECPICLELIK-EPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRS 72

Query: 72 LKNNRILDELVKSL 85
          L+ +    +LV+ L
Sbjct: 73 LQESTRFSQLVEEL 86


>gi|237681123 breast cancer 1, early onset isoform 4 [Homo
          sapiens]
          Length = 759

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 4/74 (5%)

Query: 15 VMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYK---TQCPTCCVTVTEPD 71
          V+  +  +L C IC E      +  +C H +C  C+ K L+ K   +QCP C   +T+  
Sbjct: 14 VINAMQKILECPICLELIK-EPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRS 72

Query: 72 LKNNRILDELVKSL 85
          L+ +    +LV+ L
Sbjct: 73 LQESTRFSQLVEEL 86


>gi|6552299 breast cancer 1, early onset isoform 1 [Homo sapiens]
          Length = 1863

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 4/74 (5%)

Query: 15 VMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYK---TQCPTCCVTVTEPD 71
          V+  +  +L C IC E      +  +C H +C  C+ K L+ K   +QCP C   +T+  
Sbjct: 14 VINAMQKILECPICLELIK-EPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRS 72

Query: 72 LKNNRILDELVKSL 85
          L+ +    +LV+ L
Sbjct: 73 LQESTRFSQLVEEL 86


>gi|25777698 tripartite motif-containing 39 isoform 2 [Homo
          sapiens]
          Length = 488

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 4/73 (5%)

Query: 14 AVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKF---LSYKTQCPTCCVTVTEP 70
          A ++ +     C +C EY    +II +C HN+C  CI ++   L     CP C  T    
Sbjct: 18 AALENLQVEASCSVCLEYLKEPVII-ECGHNFCKACITRWWEDLERDFPCPVCRKTSRYR 76

Query: 71 DLKNNRILDELVK 83
           L+ NR L  +V+
Sbjct: 77 SLRPNRQLGSMVE 89


>gi|25777696 tripartite motif-containing 39 isoform 1 [Homo
          sapiens]
          Length = 518

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 4/73 (5%)

Query: 14 AVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKF---LSYKTQCPTCCVTVTEP 70
          A ++ +     C +C EY    +II +C HN+C  CI ++   L     CP C  T    
Sbjct: 18 AALENLQVEASCSVCLEYLKEPVII-ECGHNFCKACITRWWEDLERDFPCPVCRKTSRYR 76

Query: 71 DLKNNRILDELVK 83
           L+ NR L  +V+
Sbjct: 77 SLRPNRQLGSMVE 89


>gi|7705415 hook homolog 1 [Homo sapiens]
          Length = 728

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 48/228 (21%), Positives = 88/228 (38%), Gaps = 28/228 (12%)

Query: 224 LSREEKKES-----LRSSVHKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKRH 278
           LS E K+       ++    K + L K    L+  RD  K+  E     Q  +  L    
Sbjct: 385 LSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHL---- 440

Query: 279 QEFVHMYNAQCDALHPKSAAEIVQEIENIEKTRMRLEASKLNESVMVFTKDQTEKEIDEI 338
                    Q DA   KS   +  EI  +E   + +     N+ + +  +    + I+E+
Sbjct: 441 --------NQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEEL 492

Query: 339 HSKYRKKHKSEFQLLVDQARKGYKKIAGMSQKTVTITK---------EDESTEKLSSVCM 389
             +  +KH+   +L  +Q R   ++I  + Q+   + K         E ES+ KL     
Sbjct: 493 QEQLEQKHRKMNELETEQ-RLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLE 551

Query: 390 GQEDNMTSVTNHFSQSKLDSPEELEPDREEDSSSCIDIQEVLSSSESD 437
              + +T V     Q K +  E+L+PD  ++     +++  L   + D
Sbjct: 552 AHMEKLTEVHEEL-QKKQELIEDLQPDINQNVQKINELEAALQKKDED 598


>gi|58761530 polycomb group ring finger 6 isoform a [Homo sapiens]
          Length = 350

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 4/65 (6%)

Query: 25  CGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTV--TEP--DLKNNRILDE 80
           C IC  Y   A  I +C H +C  CI +   Y  +CP C + V  T+P  +++ +R L +
Sbjct: 134 CSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQD 193

Query: 81  LVKSL 85
           +V  L
Sbjct: 194 IVYKL 198


>gi|94536782 tripartite motif-containing 35 isoform 2 [Homo
          sapiens]
          Length = 493

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 20/71 (28%), Positives = 37/71 (52%), Gaps = 3/71 (4%)

Query: 17 KTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQ--CPTCCVTVTEPDLKN 74
          ++  + L C +C++ F  A+ + +C HN+C  C+ +    +    CP C    +  DL+ 
Sbjct: 13 RSFKEELLCAVCYDPFRDAVTL-RCGHNFCRGCVSRCWEVQVSPTCPVCKDRASPADLRT 71

Query: 75 NRILDELVKSL 85
          N  L+ LV+ L
Sbjct: 72 NHTLNNLVEKL 82


>gi|223890259 midline 2 isoform 2 [Homo sapiens]
          Length = 705

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 68/336 (20%), Positives = 130/336 (38%), Gaps = 78/336 (23%)

Query: 16  MKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKT------------QCPTC 63
           M+T++  L C IC E F   +++P C+H+ C  C  + L                QCPTC
Sbjct: 21  METLESELTCPICLELFEDPLLLP-CAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTC 79

Query: 64  CVTVTEPDLKNNRILDELVKSLNFARNHLLQFALESPAKSPASSSSKNLAVKVYTPVASR 123
              ++     N+R LD L +++   +N + +F  +  + S  +S S++   + Y P  + 
Sbjct: 80  RYVIS----LNHRGLDGLKRNVTL-QNIIDRF--QKASVSGPNSPSESRRERTYRPTTAM 132

Query: 124 QSLKQGSRLMDNFLIREMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAPDPS 183
            S +   +  +                        P ++A     T E    +       
Sbjct: 133 SSERIACQFCEQ----------------------DPPRDAVKTCITCEVSYCDRCLRATH 170

Query: 184 EAKRP-------EPPSTSTLKQVTKVDCPVCGVNIPESHINKHLDS-CLSREEKKESLRS 235
             K+P       EP   + L+ +T +D           H N+ ++  C+S ++   +L  
Sbjct: 171 PNKKPFTSHRLVEPVPDTHLRGITCLD-----------HENEKVNMYCVSDDQLICALCK 219

Query: 236 SVHKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCD----- 290
            V + +      + + S  D  +KLK+   +++ N   L+KR+ E  +            
Sbjct: 220 LVGRHRD-----HQVASLNDRFEKLKQ---TLEMNLTNLVKRNSELENQMAKLIQICQQV 271

Query: 291 ----ALHPKSAAEIVQEIENIEKTRMRLEASKLNES 322
               A+H     E   E+  I + R ++ A K+ E+
Sbjct: 272 EVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKET 307


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.125    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,842,422
Number of Sequences: 37866
Number of extensions: 865707
Number of successful extensions: 5012
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 95
Number of HSP's successfully gapped in prelim test: 461
Number of HSP's that attempted gapping in prelim test: 4350
Number of HSP's gapped (non-prelim): 1050
length of query: 495
length of database: 18,247,518
effective HSP length: 106
effective length of query: 389
effective length of database: 14,233,722
effective search space: 5536917858
effective search space used: 5536917858
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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